cyrilzakka/clinical-trials huggingface dataset:
LIFE-TB ; Long-Term Impacts on Lung Health and Life After Tuberculosis in Korea

This is a prospective, multicenter observational cohort study aimed at establishing a nationwide post-TB lung disease registry in Korea. The study will enroll adult participants either undergoing treatment for pulmonary tuberculosis or with a history of treated TB. Over a five-year follow-up period, the study will assess the long-term health consequences of TB, focusing on respiratory symptoms, radiological changes, pulmonary function, and quality of life.

"The LIFE-TB (Long-Term Impacts on Lung Health and Life After Tuberculosis in Korea) study is a nationwide, prospective, multicenter observational cohort designed to systematically investigate the long-term impacts of tuberculosis (TB) on lung health and quality of life. This registry aims to fill the critical evidence gap in understanding post-TB lung disease (PTLD) by enrolling adults with a current diagnosis of pulmonary TB or a history of TB treatment.

Participants will be recruited from six tertiary care centers across Korea. Eligible individuals include those aged 19 or older who are either undergoing anti-TB treatment or have completed it. Exclusion criteria include extrapulmonary TB without lung involvement, age under 19, or refusal to consent.

Data will be collected at baseline and regularly over a five-year follow-up period. Clinical variables include demographic information (age, sex, BMI, smoking status), TB-related history (sputum smear/culture, drug resistance, treatment outcomes), comorbidities, and current medications. Clinical assessments involve standardized symptom scores (mMRC), chest imaging (X-ray and CT), spirometry, and validated instruments to assess quality of life (EQ-5D-5L, PROMIS, SGRQ). Laboratory data include blood tests (HbA1c, lipids), HIV/HBV/HCV status, and urine and ECG assessments at baseline.

Participants will be followed annually, with interim assessments including imaging, spirometry, and symptom scoring at specified intervals. No study-specific interventions or additional imaging are required beyond routine care. Chest CTs will only be collected if obtained for clinical purposes.

The study's primary objectives are to describe the prevalence and trajectory of PTLD-related abnormalities and identify factors associated with poor outcomes. Secondary analyses include trends in pulmonary function and quality of life over time, as well as health utilization patterns. Statistical analyses include descriptive statistics and multivariable logistic regression to identify risk factors.

All data will be anonymized and securely stored, following institutional and ethical guidelines. The study will contribute essential real-world data to inform national and international post-TB management strategies."

Eligibility Criteria:
Inclusion Criteria:

* Age ≥19 years
* Diagnosed with pulmonary TB and either initiating or undergoing treatment or history of treated pulmonary TB

Exclusion Criteria:

* Age \<19 years
* Extrapulmonary TB without lung involvement
* Refusal to provide informed consent
Improving Drop Instillation Comfort of a Cyclosporine A Solution

Patients who suffer from dry eye disease are often prescribed eye drops containing cyclosporine A that help with reducing inflammation. The newest eye drop containing cyclosporine A is called Cequa (Sun Pharma, Canada). Unfortunately, nearly a quarter of (24.2%) of patients using Cequa have reported some form of discomfort (burning and stinging) when instilling the drops. This potentially discourages patients from continuing the eye drop, which prevents their dry eye disease from being managed effectively. This study is trying to determine if refrigerating the eye drops would allow the drops to feel more comfortable when they are instilled in the eye.


Eligibility Criteria:
Inclusion Criteria:

* Over 18 years of age.
* Ocular Surface Disease Index score \>= 23.
* Strip meniscometry \< 5 mm.

Exclusion Criteria:

* Contact lens wearers.
* Have corneal neuropathic or neurotrophic disease.
* Have an ocular or medical condition or taking medications that could confound a study outcome.
* Currently pregnant or breastfeeding (cyclosporine is a FDA pregnancy Category C drug).
* Have an ocular or medical condition for which Cequa is contraindicated (e.g., allergy to cyclosporine or other ingredients in Cequacurrent eye infection, cancer or precancerous condition in or around the eyes).
* Have an allergy to fluorescein.
Neutrophil Gelatinase-associated Lipocalin as a New Biomarker to Detect Acute Kidney Injury in Postoperative Cardiac Surgery

Observational study aimed to test the ability of Neutrophil Gelatinase-associated Lipocalin (NGAL) concentration in blood and urine to predict and diagnose early acute renal failure (ARF) in patients after cardiac surgery with/without Cardiopulmonary bypass (CPB).


Eligibility Criteria:
Inclusion Criteria:

* Men or women over 18 years proposed for cardiac surgery with / without CPB.
* Accepting to participate in the study, with informed consent signed by the patient, guardian or family member.

Exclusion Criteria:

* Patients \< 18 years.
* Patients do not agree to participate in the study.
Construction and Application of Early Lung Rehabilitation Training Programs

This study is intended to construct early lung rehabilitation training programs for adult patients after double lung transplantation, including safety assessment, exercise training, respiratory function training, psychological support and health education, with a view to helping double lung transplant patients achieve lung rehabilitation at an early date, improve patients' motor endurance and respiratory function, and improve the quality of near- and long-term survival.

The first stage constructs the lung rehabilitation program, and the second stage implements the non-contemporaneous study control trial.

Eligibility Criteria:
Inclusion Criteria:

* age ≥ 18 years
* consent to early lung rehabilitation
* informed consent to this study.

Exclusion Criteria:

* Unstable condition, not allowed to receive pulmonary rehabilitation treatment
* A person with a mental disorder who cannot cooperate.
A Survey for Factors That Influence Postoperative Treatment Decision-making for Hepatocellular Carcinoma

This is a non-interventional and questionnaire survey study. The investigators try to find out patient's willingness and expectation for post-operative treatments for hepatocellular carcinoma (HCC), as well as patients' willingness to participate in clinical trials using a questionnaire. The ultimate goal is to assist physicians in clinical treatment decision, clinical research, and government health and economic decision-making, as well as to help investigators understand how to increase public awareness of the HCC and the treatment course and efficacy of HCC, and the awareness of clinical trials.

There is no world widely accepted adjuvant therapy for HCC and the guidelines from AASLD or EASL did not recommend any adjuvant therapy to prevent postoperative tumor recurrence of HCC. The goal of an adjuvant therapy is to meet the requirements of patients, which are influenced by many factors such as the strength of doctors' recommendation, economic affordability, tolerance of adverse reactions to treatment, and expectation of efficacy. Therefore, understanding patients' expectations for an adjuvant therapy after surgery will help doctors give more reasonable treatment. Participating in clinical trials is a new process of understanding and acceptance for each patient, so investigators try to understand the willingness and ideas of patients to participate in clinical trials, so as to provide more information for designing clinical trials and recruiting subjects for clinical trials.

The research was conducted through face-to-face interview, WeChat and telephone interview. For face-to-face interview and WeChat to participants, an informed consent should be signed.

Eligibility Criteria:
Inclusion Criteria:

* Male or female aged 18 years or older;
* Confirmed diagnosis of HCC histologically or clinically;
* The participant must have received surgical resection;
* Ability to complete the questionnaire or independently or with the help of a friend, relative, or staff member of the oncology department.

Exclusion Criteria:

* The patients that researchers consider not suitable to participate in this study.
Enhancing Clinical Reasoning Competency

Enhancing Clinical Reasoning Competency for Undergraduate Nursing Students Using Virtual Simulation-based Education based on the Rasch model

Aims: Clinical reasoning is a core nursing competency that involves analyzing patient-related data and providing appropriate nursing practices. Simulation-based education is effective in improving the clinical reasoning competencies and communication skills of nursing students. This study aimed to verify the effectiveness of virtual simulation-based education.

Methods: This study used a single-group pre- and post-test experimental design to verify the effectiveness of virtual simulation-based education. Data were collected from June to September 2020. Thirty-six nursing students in the 3rd and 4th grades who understood the purpose of this study were selected as participants. The collected data were analyzed using SPSS Statistics 25.0 and Winsteps 3.68.2.

Keywords: Clinical Reasoning, Competency, Communication, Nursing, Virtual Simulation

Eligibility Criteria:
Inclusion Criteria:

* The participants were third- and fourth-year undergraduate nursing students who understood the purpose of the study and voluntarily agreed to participate

Exclusion Criteria:

* A person who has difficulty communicating or has no willingness to participate
Study on the Effectiveness of Berlin Dissexuality Therapy as Part of the Model Project in Accordance With §65d SBG V

The main goal of this clinical trial is to learn if psychotherapy works to reduce consumption of child abuse imagages.


Eligibility Criteria:
Inclusion Criteria:

* Age at first presentation minimum 18 years
* Voluntary consent to participation on the part of the participant
* At the time of inclusion, no contact with the justice system (ongoing investigation, ongoing criminal proceedings, ongoing prison sentence) due to sexually abusive behavior towards children
* Sexually conspicuous behavior and/or fantasies or impulses that indicate the presence of a pedophilic and/or hebephilic preference disorder.
* An offer of treatment is made when a suspected diagnosis is confirmed or the diagnosis is confirmed
* Feared or recent use of abusive images
* Sufficient knowledge of German
* Voluntary participation in the study and checking the checkbox in the informed consent form before starting participation

Exclusion Criteria:

* Age under 18 years
* Lack of consent on the part of the patient
* Exclusion of the presence of a pedophilic and/or hebephilic preference disorder
* Current legal status in the sense of an ongoing investigation or criminal proceedings due to sexually assaultive behavior towards children
* Severe comorbidities: unstable psychotic disorder, organic brain damage, reduced intellectual capacity (IQ below 70), untreated drug or alcohol addiction or persistent harmful use
* Current risk of child sexual abuse and or child sexual abuse that occurred less than 15 years before the start of the study
* An antiandrogenic medication or an opiate antagonist, during therapy start taking a serotonin reuptake inhibitor.
Staple vs. Suture in Robotic Prostatectomy

The purpose of the study is to compare the results of three standard of care surgical methods \[stapling versus selective suture ligation (cut, then sew) versus single suture ligation (sew, then cut) of the dorsal venous complex (DVC)\] during robotic prostate surgery to see which is better for the patient's recovery.

The dorsal venous complex (DVC) lies on top of the prostate gland, and carries blood away from the penis. It has to be tied off, or ligated, to remove the prostate gland. The DVC lies very close to nerves that help men get and maintain erections. In addition, the DVC is close to muscles that control passing urine. How the DVC is handled during prostate surgery may result in cancer being left behind to grow and spread in the body. The purpose of this study is to compare the results of stapling versus selective suture ligation (cut, then sew) versus single suture ligation (sew, then cut) of the DVC during robotic prostate surgery to see which is better for the patient's recovery.

This research is being done because doctors do not know which of these three commonly-used methods is better to reduce blood loss and reduce the chance of cancer left behind during surgery, and regain urine control and improve erectile function after surgery. Doctors also do not know if these methods affect the prostate-specific antigen (PSA) level in the blood after surgery.

Eligibility Criteria:
Inclusion Criteria:

* Males over 18 years of age
* Must be scheduled to undergo standard of care robot-assisted laparoscopic prostatectomy (RALP)
* Must sign informed consent to be randomized between the three surgical arms

Exclusion Criteria:

* Patient is unwilling or unable to provide informed consent
Effect of Interferential Electrical Stimulation on Pain Perception and Disability Level on Interstitial Cystitis

A total of 40 volunteers women with a diagnosis of interstitial cystitis. Their ages ranged from 25 to 40 years old; their body mass index was \> 30 kg/m2 and were randomly assigned to a group (A) received interferential current at the lower abdomen, and also received traditional medicine or group (B) received traditional medicine for 8 successive weeks. Both of the groups received the treatment program for 8 successive weeks. Assessment of pain perception and disability level for all patients in both groups (A\&B) were done through Visual analogue scale, O'Leary-Sant Symptom Index or Interstitial Cystitis Index (ICSI) and blood cortisol concentration were done before and after the treatment program.

Forty volunteers women diagnosed clinically by gynecologist as painful bladder syndrome were participated in this study. They were selected randomly from the gynecological outpatient clinic, at Al-Zahra Universal Hospital, Al Azhar University, their ages ranged from 25 to 40 years and their body mass index was \> 30 kg/m2. All participants complain from suprapubic pain related to bladder filling, accompanied by other symptoms such as increased daytime and night-time frequency. Exclusion criteria of the study were as follows: Participant who had acute viral disease, acute tuberculosis and mental disorders, benign or malignant tumors of the pelvic region, Participant who had active endometriosis or having artificial pacemaker or cardiac arrhythmia, Participant who had sensory disturbances.

Participants were assigned randomly used sealed envelope into two groups (A\&B) equally in number. Group (A): Consisted of twenty patients suffering from painful bladder syndrome. They received interferential current at the lower abdomen, and also received traditional medicine (they were administered anticholinergics (propiverine hydrochloride 20 mg/once per day in the morning) for 8 successive weeks. Group (B): Consisted of twenty patients suffering from painful bladder syndrome. They received traditional medicine (they were administered anticholinergics (propiverine hydrochloride 20 mg/once per day in the morning) for 8 successive weeks

Eligibility Criteria:
Inclusion Criteria:

* their ages ranged from 25 to 40 years.
* their body mass index was \> 30 kg/m2

Exclusion Criteria:

* Participant who had acute viral disease.
* acute tuberculosis
* mental disorders.
* benign or malignant tumors of the pelvic region
Avoiding Neuromuscular Blockers to Reduce Complications

The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.

Pragmatic prospective randomized controlled assessor-blinded effect-size finding trial involving approximately 100 patients total at two academic tertiary care hospitals: Beth Israel Deaconess Medical Center (BIDMC) and Massachusetts General Hospital (MGH). Patients will be randomized into one of two study groups: standard care group which uses Rocuronium (NMBA) as an adjunct for maintenance of general anesthesia and non-relaxant arm that avoids the use of NMBA and instead uses additional inhalational anesthetics, opioids, propofol, dexmedetomidine, or ketamine for maintenance of general anesthesia. Assessment of postoperative pulmonary complications and in-hospital mortality would be achieved by close review of the patient's medical records during the hospital stay, for a maximum of 28 days.

Eligibility Criteria:
Inclusion Criteria:

* At least 18 years of age
* Undergoing non-cardiac surgery under general anesthesia with an endotracheal tube
* those at higher risk of developing postoperative pulmonary complications (internally validated risk prediction score of \>=20)

Exclusion Criteria:

* Emergency surgery
* Ambulatory (outpatient) surgery
* Scheduled for elective postoperative ventilation
* Planned return to operating room within 7 days of index procedure
* Exposure to general anesthesia within 7 days prior to planned procedure
* Requirement mechanical ventilation at baseline (not including stable use of CPAP/BiPAP)
* Pregnant patients: as detected by patient self-reporting or diagnosed by preoperative pregnancy testing according to institutional policies at BIDMC and MGH
* Allergy to either non-depolarizing muscle relaxants or sugammadex
* Clinician refusal
* Prisoner
Effectiveness of Kinesiotaping in Adolescent Idiopathic Scoliosis

The effectiveness of kinesiotaping application in addition to exercise in Adolescent Idiopathic Scoliosis will be compared on the pain level with the numerical rating scale, the Cobb angle and scoliometer measurements, the quality of life with the Scoliosis Research Association-22 quality of life scale, and the patient's visual perception level with the Walter Reed visual assessment scale. Research Group: In addition to the regular exercise program, kinesio taping will be applied to patients diagnosed with Adolescent Idiopathic Scoliosis. Kinesio taping will be applied for 5 days on and 2 days off for 4 weeks. Control Group: Patients diagnosed with Adolescent Idiopathic Scoliosis will continue their regular exercise program. No intervention will be applied. Patients will be evaluated before and 3 months after treatment in terms of pain level with numerical rating scale, Cobb angle measurement and Scoliometer measurement, quality of life with Scoliosis Research Association-22 quality of life scale and Walter Reed visual assessment scale.


Eligibility Criteria:
Inclusion Criteria:

* Being under follow-up with the diagnosis of Adolescent Idiopathic Scoliosis
* Having a Cobb angle between 10-25 degrees
* Being willing to participate in the study
* Having thoracic C scoliosis

Exclusion Criteria:

* Having a spinal curvature of more than 25 degrees
* Presence of cardiopulmonary disease and musculoskeletal deformity that will prevent exercise
* Having an open wound in the area where kinesio taping will be applied or being allergic to the tape application
* Presence of S scoliosis
Study Evaluating Combination of Levonorgestrel and Ethinyl Estradiol in Pre-Menstrual Dysphoric Disorder

The purpose of this study is to determine whether Levonorgestrel/Ethinyl Estradiol (LNG/EE) is effective in treating the symptoms of severe Premenstrual Dysphoric Disorder.


Eligibility Criteria:
Inclusion Criteria:

* Generally healthy, women aged 18 to 49 years.
* History of severe PMS symptoms over the last year, as determined by the investigator.
* Regular 21 to 35 day menstrual cycle for 2 months prior to first study visit.

Exclusion Criteria:

* Major depressive disorder requiring antidepressant treatment or hospitalization within the last 3 years.
* Contraindication to combination oral contraceptives.
* Use of antidepressants/anxiolytics within 10 days of screening and for the duration of the study.

Other exclusion applies.
Optimization of Music Compression

Hearing impaired persons suffer from inferior music perception with and without hearing aids. Hearing aids, however, are primarily designed to improve speech intelligibility not music enjoyment. This study investigates the potential benefit of signal processing strategies that are optimized for music. The purpose of this study is to improve music compression for hearing impaired people.


Eligibility Criteria:
Inclusion Criteria:

* Female and male adults between 18 and 99 years
* German-speaking
* Symmetric, mild to severe, ski-slope hearing loss
* Binaural hearing aid user without frequency lowering
* Informed Consent as documented by signature

Exclusion Criteria:

* Have taken part in a study at Phonak within 4 months prior to the first session
* People with mental-health problems
* People whose audiogram is older than 12 months and it is not possible make a reliable measurement
* Very limited motor activity or mobility
Biofreeze® vs. a Placebo on Knee Osteoarthritis Walking Gait Characteristics and Pain

The purpose of this study is to determine the effect of Biofreeze® versus a placebo on walking gait characteristics and pain during walking in individuals with bilateral knee osteoarthritis (OA).

A convenience sample of 20 participants, \>40 years with previously diagnosed bilateral KOA were recruited. Participants must have been diagnosed with bilateral knee OA and be able to perform all study procedures. All participants reported in comfortable clothing and sneakers. After explanation of the study and consent, participants completed the demographics questionnaire, Numeric Pain Rating Scale (NPRS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and knee function survey. Participants then completed a 3mph 3-minute walking baseline assessment. Following the assessment, participants rated their pain and were randomly assigned to receive a blinded topical of either Biofreeze® or a Placebo. The dose of both gels was 5 mL per knee. The participant then waited 15 minutes, rated their pain, and repeated the 3-minute walking assessment and rated their pain once more. There was a minimum of a 24-72-hour washout period after which time the participants repeated the same protocol using the other topical.

Eligibility Criteria:
Inclusion Criteria:

* must have been diagnosed with bilateral knee osteoarthritis (OA) and be able to perform all study procedures

Exclusion Criteria:

* less than 40 years of age, pregnancy, cancer, rheumatoid arthritis, a total or partial knee replacement, and/or a corticosteroid injection within the past 4 weeks
Levetiracetam Versus Valproate in Idiopathic Generalized Epilepsy

This study aimed to compare the long-term efficacy and safety of levetiracetam and valproate in treatment of idiopathic generalized epilepsy.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of juvenile myoclonic epilepsy or generalized tonic-clonic seizure alone
* Regular monotherapy with levetiracetam or sodium valproate

Exclusion Criteria:

* Poor drug adherence
* Pregnancy