cyrilzakka/clinical-trials huggingface dataset:
Managing Urinary Incontinence in Elderly Village Women in Rural Bangladesh

An intervention consisting of group and home based exercise will be used over 6 months to assess whether this is helpful in managing urinary incontinence in elderly village women in Bangladesh. This intervention, supplemented by education about managing incontinence, will be used in half the villages in the trial. In the other half women will receive only the education component.

This is a cluster randomized trial in which all women aged 60-75 years reporting symptoms of urinary incontinence are randomly assigned, by village of residence, to either exercise plus education of to education alone.

Eligibility Criteria:
Inclusion Criteria:

* Women aged 60-75 years reporting incontinence on a screening questionnaire (yes to questions 2,3or 4 on the 6 item Urinary Distress Index)

Exclusion Criteria:

* They report a uterine prolapse which is (or becomes) known to be of 3rd degree or higher.
* They are assessed by the village paramedic to be incapable of standing from sitting without help from someone else.
* They are assessed by the village paramedic to be unable to walk without help at a normal pace for someone of her age.
* They are assessed by the village paramedic as not having the intellectual capacity to understand questions and follow instructions.
Comparative Effects of Papworth Technique Versus Pranayama in Asthmatic Patients

Asthma is a chronic and heterogeneous disease characterized by reversible airway obstruction, airway inflammation and bronchial damage causing dyspnea, wheezing, chest tightness, coughing and impaired quality of life. Papworth technique and Pranayama modify the pattern of breathing to reduce the hyperventilation resulting in normalization of CO2 levels, reduction of bronchospasm and resulting breathlessness

.These techniques also change the emotional stresses, improve the immunity system and improve the strength /endurance of respiratory muscles. After taking the consent form from the participants, data will be collected from Gulab Devi Chest Hospital. Non-Probability Convenience Sampling will be applied on asthmatic patients according to inclusion criteria. Patients will be allocated through simple random sampling into group A and B to collect data. Group A will be treated by Papworth technique. Four weeks will be required to complete the treatment plan. Three sessions will be given for one week so total 12 sessions will be given in one month. Group B will be treated by Pranayama. Four weeks will be required to complete the treatment plan. Three sessions will be given for one week so total 12 sessions will be given in one month. Papworth Technique and Pranayama are used and are assessed to see their effectiveness in asthmatic patients by using four questionnaires on dyspnea, fatigue, anxiety, depression and quality of life. These four standardized questionnaires are Borg Dyspnea Scale (BDS), Modified Fatigue Impact Scale (MFIS), Hospital Anxiety Depression Scale (HADS) and Asthma Quality of life. Pulse oximeter will be used to check the oxygen saturation. The study duration will be completed within time duration of 7 months.


Eligibility Criteria:
Inclusion Criteria:

* Both genders(male and female)
* Age 20-40 years
* Patients with adverse mood effects
* Mild to moderate chronic asthma

Exclusion Criteria:

* Acute severe asthma
* Chronic chest infections like TB
* Chest deformity
* Bronchiectasis
* Cardiac Disease
* Substance abusers
* Chronic Obstructive Pulmonary Disease
* Neurological Disorders
Effect of Citrus Bioflavonoids/Vitamin E in Conjunction With Fish Oil Supplementation

The purpose of this 8-week intervention trial is to investigate the effect of a dietary supplement (containing citrus bioflavonoids and vitamin E) plus fish oil supplementation in healthy hyperlipidemic subjects


Eligibility Criteria:
Inclusion Criteria:

* men and women ≥ 18 and ≤ 72 years old
* generally healthy
* BMI \> 18 and \< 38
* LDL cholesterol ≥ 130 mg/dl and \< 270 mg/dl
* triglycerides ≥ 150 mg/dl and \< 400 mg/dl
* ability to understand and the willingness to sign a written informed consent

Exclusion Criteria:

* use of nutritional supplements and medical foods for dyslipidemia within 30 days prior to the study
* use of omega-3 fatty acid dietary supplements within 30 days prior to the study
* use of prescription HMG-CoA reductase inhibitors, bile acid sequestrants, fibrates, cholesterol absorption blocking agents, or niacin
* use of prescription medications and/or nonprescription medications for acute and semi-acute medical conditions
* history of cardiovascular disease, type i diabetes, autoimmune disease, liver or kidney disease, malignancy, and serious mental illness.
* known infection with HIB, TB, hepatitis B or hepatitis C
* history of allergy or intolerance to study products
* smoking, use of nicotine-containing products, or use of drugs of abuse 30 days prior to the study
* history of regular intake of \> 14 alcoholic drinks per week for females and \> 21 drinks per week for males
Perception of Cardiovascular Risk

The aim of the study is to describe the association between the perception of cardiovascular (CV) risk and the actual CV risk and, secondarily, to detect the actual CV risk to assess the prevalence of clinical risk factors, determined by means of appropriate instruments.

Cardiovascular (CV) disease is the major cause of premature death in adults that carries serious economic consequences.

Risk perception for CV disease has been reported as the subjective judgment of the likelihood of having a CV event. Risk perception is an important precursor to adopting a healthy lifestyle. However, both overestimation and underestimation of actual risk due mostly to poor health literacy are common.

For these reasons, CV prevention services of health care professionals (e.g., nurses, physicians) should, on the one hand, include screening for the presence of risk factors, and on the other hand, know the CV risk perceptions of those being cared for.

The aim of the study is to describe the association between the perception of cardiovascular (CV) risk, investigated by means of the Perception of Risk of Heart Disease Scale and a Likert-5 scale question, and the actual CV risk according to the SCORE2 and, secondarily, to detect the actual CV risk ascertained by the SCORE2 and to assess the prevalence of clinical risk factors (alterations in the lipid, glucose, or anthropometric profile) determined by means of appropriate instruments.

Eligibility Criteria:
Inclusion Criteria:

* an age between 18 and 69 years of age
* subscription to informed consent.

Exclusion Criteria:

* patients with a positive history of hospitalization due to CV pathology at the time of enrollment;
* patients with ongoing relevant cognitive debilitation (Six Item Screener score \< 4)
Lidocaine Patch for Treatment of Persistent Inguinal Postherniorrhaphy Pain

In the present placebo-controlled cross-over study the researchers intend to investigate analgesic and sensory effects of a lidocaine patch in patients with severe persistent inguinal post-herniorrhaphy pain.


Eligibility Criteria:
Inclusion Criteria:

* Males \> 18 yrs
* ASA (American Society´s of Anesthesiology´s classification) scores I-III, with severe Pain for more than six months and with average daily pain intensities (numerical rating scale \[NRS\] 0-10 points) during rest or during movement \> 6.

Exclusion Criteria:

* History of an allergic reaction or intolerance to amide local anesthetics or vehicle ingredients in the patches
* Use of class I antiarrhythmic drugs (e.g., tocainide and mexiletine)
* Severe cardiac impairment, e.g., NYHA (New York Heart Association) Class ≥ III
* Inflamed or injured skin at the application site
* Known severe hepatic disorder (Child-Pugh score \> 6)
* Known severe renal impairment, (creatinine clearance \< 30 mL/min)
* Signs of cognitive impairment or known drug or ethanol abuse during the last 2 years.
Osteopathic Manipulative Treatment in Chronic Non-specific Neck Pain

The aim of this study is to investigate the effect of osteopathic manipulative treatment on pain intensity, disability level and psychosocial factors in patients with chronic non-specific neck pain. We hypothesed that osteopathic manipulative treatment is better than conventional physiotherapy in management of pain, disability and depression.

This study will conduct between April 2020 and July 2020 at Denizli State Hospital. Participants who were diagnosed as chronic non-specific neck pain by a specialist physician will include the study. They will treated at physical therapy clinic. Inclussion criteria will; participants diagnosed as non-specific neck pain by the physician and Non-spesific neck pain at least 3 months. Exclussion criteria were; participants who have had surgery or are indicated for surgery, participants who have had exercise therapy and / or physical therapy in the last 1 year with a history of trauma to the cervical region, participants who have had neck pain that develop due to a particular cause such as tumor, compression fracture, metastasis and infection. According to power analysis, 102 participant will include the study with 95% coincidence interval and 80% power. Participants will be divided into 2 groups. Randomization method will be closed envelope. Group 1 will receive Conventional Physiotherapy Programme (CP), Group 2 will receive Osteopathin Manipulative Treatment (OMT). Pain Intensity at rest and activity, psychological state( Beck Depression Inventory) and Disability level (Neck Disability Index) will assess at baseline and 3 weeks.

Eligibility Criteria:
Inclusion Criteria:

* participants diagnosed as non-specific neck pain by the physician.
* Non-spesific neck pain at least 3 months.

Exclusion Criteria:

* participants who have had surgery or are indicated for surgery
* participants who have had exercise therapy and / or physical therapy in the last 1 year with a history of trauma to the cervical region
* participants who have had neck pains that develop due to a particular cause such as tumor, compression fracture, metastasis and infection
Stereotactic Body Radiation Therapy (SBRT) for Tumors Near the Spinal Cord

The purpose of this research study is to determine if Stereotactic Body Radiation Therapy (SBRT) is a good way to treat tumors near the spinal cord. Patients will either receive a single treatment or 25 days of treatment given once-a-day, Monday through Friday for about 5 continuous weeks. Our protocol uses life expectancy, patient preference, and tumor size to determine whether SBRT is delivered with 1 or 25 treatments. The single treatment dose is 15 Gy. The 25 treatment group is 70 Gy at 2.8 Gy/treatment.

This protocol is a study of the use of Stereotactic Body Radiation Therapy (SBRT) for all types of primary or metastatic tumors near the spinal cord. The major goal of this study is to evaluate the efficacy and toxicity of a specific SBRT program in a prospective manner. The main outcome variables in this study are pain and neurologic function.

A major issue in delivering SBRT is the number of treatment sessions. There are advantages and disadvantages to both single and multi treatment programs. In this protocol, patients are offered SBRT with either a single treatment or 25 treatment days. This study is not designed to compare different SBRT schedules. A single treatment program is more convenient and likely to relieve symptoms sooner than a multi-session program. A program with 25 treatments may produce better long-term results. Our protocol uses life expectancy, patient preference, and tumor size to determine whether SBRT is delivered with 1 or 25 treatments.

Eligibility Criteria:
Inclusion Criteria:

* Informed consent to participate in this protocol
* Patient of all ages are eligible
* All tumor types are eligible
* Patients with prior spine radiotherapy and/or surgery to the involved area are eligible
* The tumor target must be visible on MRI or CT scan
* Stereotactic Body Radiation Therapy (SBRT) on this protocol may produce a better outcome than conventional radiotherapy

Exclusion Criteria:

* Patients who are likely to have a satisfactory outcome with surgical resection, embolization, or radiofrequency ablation without the addition of radiotherapy
* Tumor size, shape, or location is such that it is not reasonable to think the patient may benefit from SBRT as given in this protocol
* The full extent of the tumor cannot be visualized on MRI or CT scan
* Delaying radiotherapy for the time that it takes to start SBRT may compromise outcome compared to starting conventional radiotherapy immediately
* The patient cannot be positioned reproducibly due to pain or other factors
Effects of Action Observation Therapy and Motor Imagery Administered During Immobilization Period After Surgical Fixation of Distal Radius

The goal of this trial is to verify the effectiveness of Motor Imagery and Action Observation Training in subjects undergoing surgery for distal radius fracture fixation. The main question it aims to answer is:

- can action observation and motor imagery training administered during immobilisation period improve functional outcome after distal radius fracture fixation? Participants will be asked to perform hand dexterity test and grip and pinch strength evaluation Subjects assigned to control group will follow standard care


Eligibility Criteria:
Inclusion Criteria:

* Right handed subjects
* Subjects after surgical distal radius fracture fixation

Exclusion Criteria:

* Concomitant fractures of upper limbs
* Pathological fractures
* Cognitive or psychiatric disorders
* Neurological or reumatici diseases
Comparative Study Between Different Mobilization Techniques for Patients with Chronic Tennis Elbow

Background: Tennis elbow is a common musculoskeletal disorder affecting the functional activities of daily living through common extensor tendinopathy. There is a limited knowledge about neural restriction as a source of movement limitation in patients with tennis other than enriched joint mobilization techniques knowledge.

Objectives: This study will be designed to determine the efficacy of adding different mobilization techniques along with eccentric exercises on elbow pain intensity, functional disability, hand grip strength and pain pressure in patients with chronic tennis elbow.

Methods: Forty five patients with lateral epicondylitis with their ages ranged from 18 and 45 more than six weeks will be randomly assigned into three groups. Group A will receive Maitland joint mobilization techniques. Patients in group B will receive Mulligan mobilization techniques while patient in group C will receive radial nerve mobilization.. Both groups will receive eccentric exercises for wrist extensors . Patients will be treated three session per week for four week and they will be evaluated pre and post treatment for pain severity using by visual analogue scale, level of functionality by DASH questionnaire, hand grip strength by hand held dynamometer and pressure pain threshold(PPT) by pressure algometer.

Results: All the outcome variables will be assessed at baseline and 4weeks following the treatment period.


Eligibility Criteria:
Inclusion Criteria:

* This study will include individuals between the ages of 18 and 45 who have been diagnosed with lateral epicondylitis based on positive results from the Mill's and Cozen's tests. The participants must also have complaints of local tenderness at the elbow that lasts longer than six weeks. Additionally, to complete the assessment and get treatment, the participants' elbow must have a full extension range of motion

Exclusion Criteria:

* Individuals diagnosed with cervical radiculopathy, upper thoracic outlet syndrome, rheumatoid arthritis, myositis ossificans, carpal tunnel syndrome, recent upper limb trauma, elbow immobilization, steroid injection administration within the previous six months, and any history of physical therapy administered within the previous six months were excluded from the study. Furthermore, participation will not be permitted for anyone who has previously experienced discomfort because of their profession
the Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects in Adult Subjects With Elevated LDL-C

This is a randomized, placebo-controlled, single ascending-dose (SAD) study of administered SC to adult subjects with elevated LDL-C. Subjects who have signed an Ethics Committee (EC)-approved informed consent form (ICF) and have met all the protocol eligibility criteria during screening may be enrolled into the study.


Eligibility Criteria:
Inclusion Criteria:

1. Male and female subjects, aged 18 to 60 years, inclusive
2. Body mass index between 18 and 32 kg/m2, inclusive, with body weight \> 45 kg for females and \>50 kg for males
3. Serum LDL-C ≥100 mg/dL (2.6 mmol/L) at screening and Day -1
4. Fasting triglycerides \< 400 mg/dL (\<4.52 mmol/L) at screening and Day -1

Exclusion Criteria:

1. Known underlying disease or medical condition that may have a potential impact on general safety assessment, lipid metabolism, or glucose metabolism, or surgical condition (including, but not limited to, bariatric surgery) that, in the opinion of the investigator, may interfere with the interpretation of the results of the clinical study
2. Received any medication including, but not limited to, statins, ezetimibe, or lipid-altering nutrients within 30 days prior to screening, or PCSK9 antibody within 90 days prior to screening, or any LDL-C-lowering siRNA therapy within 12 months prior to screening
3. History of multiple drug allergies or allergic reactions to oligonucleotides or N-acetylglucosamine (GalNAc)
4. Subjects with alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> 1.5 times the upper limit of normal (ULN) at the time of screening (one repeat of the screening assay is permitted) with clinically significant ALT and/or AST \> ULN and ≤ 1.5 times the ULN as determined by the investigator
5. Any medical condition that, in the opinion of the Investigator, makes the subject unsuitable for enrollment or may interfere with the subject's participation in or completion of the study. This includes, but is not limited to: history or presence of cardiovascular disease (including peripheral arterial and cerebrovascular disease); diabetes mellitus (except for diabetes mellitus of pregnancy in remission); cerebrovascular accidents; and abnormal thyroid function.
Quality of Life After Arthroscopic Rotator Cuff Repair

The goal of this longitudinal study is to understand the postoperative quality of life and dynamic trajectory of shoulder function in individuals with rotator cuff tears.

Rotator cuff tears (RCTs) involve rupture of shoulder tendons or muscles, leading to pain and weakness. Its prevalence increases with age and is influenced by factors such as handedness, obesity, and smoking. Although conservative treatments are common, surgery aims to restore function. However, limited research has been conducted on postoperative psychological and social changes. Patient-reported outcome (PRO) and health-related quality of life (HRQOL) assessments are gaining importance, offering comprehensive insights into patient experiences.

This longitudinal study will include 200 randomized controlled trials (RCTs) of patients who undergo surgery. Demographics, physical examinations, and scales, such as ASES, WORC, WHOQOL-BREF, and EQ-5D, are collected preoperatively and at 2 weeks and 3, 6, 9, and 12 months postoperatively. MRI is used to assess postoperative healing at 6 months. Statistical analyses are performed using SAS software encompassing chi-square, t-tests, linear mixed effects models, and subgroup analyses to identify determinants of postoperative quality of life and functionality.

Eligibility Criteria:
Inclusion Criteria:

-Patients were evaluated by orthopedic surgeons as having a rotator cuff tear between August 2021 and July 2022, confirmed by magnetic resonance imaging (MRI) or ultrasound. If the patients required surgery and were willing to participate in the trial, the research assistant provided informed consent.

Exclusion Criteria:

1. Acromioclavicular arthritis requiring distal clavicular resection.
2. Severe glenohumeral arthritis (Hamada classification grade 3 or higher).
3. History of shoulder fracture.
4. Absolute contraindications to MRI, such as claustrophobia, pacemakers, neurostimulators, drug infusion pumps, artificial inner ear implants, and metallic implants.
Real World Study of Four PD-1 Agents in China

Consecutive patients treated with PD-1 therapy in Qingdao City were included in our study. The effecy and safety of the four PD-1 agents according to clinical outcomes in real world will be studied.

Consecutive patients treated with PD-1 therapy in Qingdao City were included in our study. The effecy and safety of the four PD-1 agents according to clinical outcomes in real world will be studied. ORR will be studied of the four PD-1 agents（nivolumab, pembrolizumab, toripalimab, sintilimab）

Eligibility Criteria:
Inclusion Criteria:

* Patients with lung cancer, liver cancer and other solid cancers
* Histologically or cytologically confirmed diagnosis cancer treated with PD-1 agents
* At least one measurable lesion
* Eastern Cooperative Oncology Group (ECOG) Performance Scale 0 or 1 Adequate organ function

Exclusion Criteria:

* patients treated with PD-1 agents less than 2 terms
Perceived Stress and Negative Thoughts With Biomarkers in People With Type 2 Diabetes Mellitus and Healthy Subjects

The purpose of this study is to determine the effect of measured and induced negative feelings on glucose, tumor necrosis factor alpha, and cortisol levels in healthy participants and participants with type 2 diabetes mellitus.

Depression and Diabetes are two pathologies that are frequently comorbid. Stress and negative thoughts are part of both. The biological correlates of psychological and emotional life are not yet fully clarified, so in this study we wonder about the association between tumor necrosis factor alpha, cortisol, and peripheral glucose levels with depression stress, measured negative thoughts, and induced guilt.This is a randomized intervention study. At baseline, participants complete the Beck Depression Inventory, the Automatic Negative Thoughts Scale (ATQ-N), and the Perceived Stress Scale (PSS-14). The intervention consists of a written task about situations that involved feelings of guilt or neutral situations. Saliva and dextrostix samples are taken before the 20-minute written task, at the end, dextrostix and saliva samples are performed again, finally a blood sample is taken.

Eligibility Criteria:
Inclusion Criteria:

* Written, informed consent.
* 30 to 65 years of age.
* Current diagnosis of Diabetes mellitus type 2 without diabetic foot.
* Healthy volunteers.
* Ability to read and write.

Exclusion Criteria:

* Other current or past chronic disease diagnoses.
* Current use of antidepressants or other psychiatric medications.
* Steroid medication.
* Consumption of tobacco or alcohol in the last 24 hours.
* Previous diagnosis of autoimmune diseases