cyrilzakka/clinical-trials huggingface dataset:
Ultrasound Epidural Technique

Epidural analgesia for abdominal surgeries provides numerous advantages for both neonates and children. The anatomical identification of the intervertebral space to access the epidural space is not constantly easy this is due uncertainty of the direction of the needle angle and the difficulty to estimate the epidural depth in spite of the skill of the operator. This can lead to more puncture attempts, inducing more pain or discomfort and even failure of epidural access.

Pre-procedure neuraxial ultrasound (US) imaging facilities the identification of the chosen intervertebral space, the depth of the epidural space and so the selection of best point and angle for the needle insertion

The aim of this study is to evaluate the efficacy of prepuncture ultrasonography to facilitate epidural block in pediatric patients undergoing elective urological operations compared with the conventional anatomical landmark technique

Eligibility Criteria:
Inclusion Criteria:

* Pediatric patients aged from 1 to 12 years old
* Both genders
* American Society of Anesthesiologists (ASA) physical status I,II, III
* Scheduled for open midabdominal urological surgeries under general anesthesia

Exclusion Criteria:

* Pediatric patients aged less than 1 or more than 12 years old
* American Society of Anesthesiologists (ASA) physical status Iv
* Parents' refusal to participate in the study
* Any contraindication to epidural block (as severe infection at the puncture site, coagulopathy or hemodynamically unstable patients)
* Neuromuscular diseases
* Severe spinal deformity
* History of allergy to the anesthetic drugs
Fibrin Monomer Compared With Hemostatic Sponge in the Integrity of the Graft During Tympanoplasty

The diagnosis of tympanic perforation reaches a high number of records in otorhinolaryngology services worldwide. Most of the tympanoplasties are performed in patients whose cause of perforation and hearing loss was chronic otitis media; this entity affects the population between 0.5 to 30% , the statistics mention more than 20 million people with this disease in the world. Since the introduction of tympanoplasty in the second half of the nineteenth century there have been numerous publications nationally and internationally about various experiences and new techniques. Including the use of fibrin monomer . This procedure is usually performed with the use of hemostatic sponge and recently with fibrin monomer, both materials are part of the basic input and surgical hemostatic agents. In this hospital are performed on average 110 tympanoplasty per year which has a percentage of non- integrity of the graft in the case of microscopic tympanoplasties using hemostatic sponge of 16% which is similar to the index of lack of integrity of the graft in microscopic tympanoplasties reported worldwide (18%), with the recent addition to the service of fibrin monomer, was necessary to evaluate if this material contributes to the integrity of the graft in microscopic tympanoplasty, as it has been reported in previous studies, so if there is found more integrity with this material, it can be recommended for routine use, improving the final prognosis of the patients.

Objective: Assess the effect of fibrin monomer in the integrity of the graft during tympanoplasties compared with the effect of the hemostatic sponge at the hospital of specialties Western Medical Center.

Material and Methods: Clinical trial with single blind, parallel-groups and randomized assignation. There were included patients with a diagnosis of tympanic perforation, candidates for surgical treatment by performing only microscopic tympanoplasties, which fulfilled the selection criteria. The main variable of the study was the integrity of the graft.

The statistical analysis was performed according to the nature of variables, for continuous data using measures of central tendency and dispersion and for the qualitative data with frequencies and percentages. To evaluate the effect of fibrin monomer relative to the hemostatic sponge, the data relating to the integrity of the graft between the groups were analyzed by chi-square.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with tympanic perforation and with surgical indication of Tympanoplasty (without otorrhea for 6 months)

Exclusion Criteria:

* Background of tympanic perforation caused by allergic or pulmonary diseases including asthma and allergic rhinitis.
The Effects of Bromelain Supplement in Patients with Diabetic Foot Ulcers

This study will be conducted on people over 18 with diabetic foot ulcers.. The first group will receive the standard treatment along with bromelain supplement and the second group will receive the standard treatment and placebo. The informed consent form prepared in advance will also be provided to the patients so that they are fully familiar with the study process. Wound surface area, rate of pain, rate of inflammatory factors (ESR and CRP) will be assessed at baseline and every two weeks.


Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years old
* Patients diagnosed with diabetic foot ulcers of category 0, 1 and 2 according to the Wagner criteria
* Patients aware of the study process for monitoring after filling out the informed consent form

Exclusion Criteria:

* People who are allergic to pineapple, celery, carrot and fennel
* Pregnant and lactating women
* Severe kidney failure (GFR\<30)
* Severe liver failure (Child Pugh B, C)
* Patients with hemophilia
* People taking anticoagulant drugs, anti-platelet and thrombolytic
* Patients with irregular heartbeat and tachycardia
* Patients with asthma
Non-invasive Brain Stimulation for Gait Improvement in Patients With Spinal Cord Injury

to optimize the functional outcome in early phase of gait rehabilitation in subacute incomplete SCI patients using rTMS as an additional treatment to physical therapy (e.g. to gait training in Lokomat®). Using this add-on therapeutic strategy, we expected larger improvement of gait function than with physical therapy alone.

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive and painless procedure to modulate cortical excitability of motor areas and induce changes over the descending corticospinal output. This modulation may be useful to promote active recovery of motor function and to obtain functional benefit from gait rehabilitation. Through the use of repetitive high-frequency rTMS, improvement has been reported in motor and sensory functions measured by American Spinal Cord Injury Association (ASIA) Impairment Scale (AIS), and time to complete a peg-board task in four chronic incomplete cervical SCI patients.

Physical therapy aims to improve function of both undamaged and also, as far as possible, damaged neuronal structures. However, 'reorganization' of neuronal circuits is the target of specific training approaches. Therefore, the challenge is to guide CNS plasticity in order to optimize the functional outcome for a given individual. Hypothesized was that high-frequency rTMS coupled with gait training can improve motor recovery in the lower extremities and locomotion in incomplete SCI patients to a greater degree than sham stimulation.

Eligibility Criteria:
inclusion criteria:

1. had subacute motor incomplete SCI (AIS-C or D),
2. candidate for gait rehabilitation with Lokomat® after cervical or thoracic SCI;
3. stable medical treatment at least one week before and during the study;
4. without limitation of passive range of movement in joints
5. agreed to participate after signing a written informed consent form.

exclusion criteria:

1. unstable clinical state
2. severe spasticity (MAS\>=3)
3. disagreed to sign consent form
Osteoarticular Tumor Characterization by Advanced Imaging

The purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which association of methods could improve non invasive tissue characterization.

Secondary purposes are:

* to determine a possible correlation between some parameters and the histological grade (FNCLCC)
* to suggest a coherent diagnostic imaging approach for osteoarticular tumors.

The ancillary study will enroll patients needing radiological tumor follow-up. The purpose is to identify tools for evaluation of tumor activity and therapeutic response before modification of morpho-volumetric data.

Patients refered for the initial evaluation of suspected osteoarticular masses will be included in this study after signing an informed consent.

Histologic analysis will be used as a gold standard.

The following imaging techniques will be evaluated:

* contrast enhanced ultrasonography
* Low dose CT perfusion
* Magnetic resonance perfusion
* Diffusion weighted imaging
* Magnetic resonance proton spectroscopy

Eligibility Criteria:
Inclusion Criteria:

* patients examined for initial assessment of bone or peripheral soft-tissue primitive tumor
* patients with normal awareness level
* patients having signed informed consent

Exclusion Criteria:

* pregnant women
* persons deprived of liberty
* persons under legal protection or unable to give informed consent
* persons in life-threatening emergency
* allergy to Sonovue, iodinated contrast media or gadolinium chelates
* risk of pregnancy
* breastfeeding women
* acute coronary syndrome or unstable ischemic cardiopathy (ban on injection of contrast agent for CT scan)
* renal failure (ban on injection of contrast agent for MRI and CT scan)
* contraindication to MRI
Effects of Lactobacillus Paracasei PS23 on Anti-fatigue

This research is to explore the effects of supplementing Lactobacillus paracasei PS23 to reduce fatigue and improve physical fitness after exhaustive exercise.

Studies have found that the intestinal flora of athletes is different from that of ordinary people, and short-chain fatty acids play a very important role. Previous animal experiments have found that supplementing with specific probiotics can slow down muscle loss in aging mice. In addition, clinical studies have found that supplementing with probiotics can improve sports performance by regulating the intestinal flora and related metabolites. Therefore, the purpose of this research is to explore the effects of supplementing Lactobacillus paracasei PS23 to reduce fatigue and improve physical fitness after exhaustive exercise. This study compares supplementary samples with placebo and adopts a double-blind study design.

Eligibility Criteria:
Inclusion Criteria:

* Healthy adult men and women aged 20-40 who are generally non-athletic players

Exclusion Criteria:

* BMI≧27
* Known allergy to probiotics
* Have current or history of inflammatory bowel disease
* Patients using of other probiotic products (sachet, capsule or tablet) within the preceding two weeks
* Those who have taken medication such as anti-inflammatory pain killer or antibiotics in the past one month
* smoker and alcoholic
* Who have been injured within 6 months
* Who has been diagnosed and treated of cardiovascular disease, hypertension, metabolic disease, asthma, or cancer
* Have undergone surgery of liver, bladder, or gastrointestinal tract
* Who has conflict of interest with PI
Application of Aerobic and Resistance Exercise in Blood Glucose Control in Pregnant Women With GDM

Objective:The aim of this study was to explore the rationality and clinical value of aerobic exercise during pregnancy in blood glucose control of pregnant women with GDM, and to provide theoretical basis for more appropriate clinical exercise management.

Method:The subjects of gestational diabetes in the hospital from March 2023 to May 2024 were studied. The exercise exercise with daily responsible nurses was based on resistance exercise, mainly with upper limb muscle exercise, supplemented by lower limb muscle exercise and aerobic exercise. Fasting blood glucose, 2 hours postprandial blood glucose and HbA1c in pregnant women with GDM were monitored.


Eligibility Criteria:
Inclusion Criteria:

* Pregnant women with GDM without contraindications.
* Pregnant women with GDM who volunteered to participate in the project.
* Pregnant women give informed consent.

Exclusion Criteria:

* Pregnant women give up voluntarily.
* Hypoglycemia: In the presence of dizziness and other uncomfortable symptoms, people should stop exercising immediately, monitor blood sugar, and always prepare candy.
* Abdominal pain, vaginal bleeding and other symptoms of contraction should stop exercising immediately and seek medical attention in time.
* Fall: It is recommended to ensure the safety of the sports ground before exercise: keep the ground dry, clean, not easy to slip, no debris; Comfortable clothing and non-slip exercise are recommended.
Neurodevelopmental Effects of Antiseizure Medications (NEAM) - UG3 Phase

To compare in-person to remote video assessments in children to determine the reliability of remote evaluations for future neuropsychological assessments and set a precedent for future investigations.


Eligibility Criteria:
Inclusion Criteria:

1. Parents able to provide informed consent for themselves and their child
2. Access to computer and reliable internet connection for remote testing
3. Child of women with epilepsy who was taking antiseizure medications during the pregnancy of the child being enrolled into the current study
4. Child between the ages of 24 months and 30 months of age
5. Primary language is English

Exclusion Criteria:

1. Child unable to complete the cognitive assessment (e.g., expected IQ\<70)
2. Child with a major medical condition (e.g., epilepsy, diabetes, heart disease, active cancer)
3. Child who use centrally active medications
To Evaluate Safety and Effectiveness of Transcatheter Aortic Valve System in Patients With Severe Aortic Stenosis

To Evaluate the Safety and Effectiveness of Transcatheter Aortic Valve System ( Chengdu Silara Medtech Inc. ,Chengdu, China)in Patients with Severe Aortic Stenosis with or without Moderate or Lower Degree Regurgitation

Transcatheter Aortic Valve System (Chengdu Silara Medtech Inc. ,Chengdu, China) will be used for this study.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥70 years old;
2. Symptomatic severe aortic stenosis determined by echocardiogram, defined as: mean gradient ≥40 mmHg or peak jet velocity ≥4.0 m/s, or an aortic valve area \<0.8 cm2 or aortic valve area index \<0.5 cm2/m2.
3. NYHA Functional Class ≥II;
4. Life expectancy after aortic valve implantation thought to be \>1 year;
5. Native valvular or peripheral vascular anatomy is appropriate for TAVR;
6. Patient is assessed by at least two cardiothoracic surgeons and recorded as not suitable for surgery;
7. Patient can understand the purpose of the study, voluntarily participates and signs the informed consent form and is willing to accept the relevant examination and clinical follow-up visits.

Exclusion Criteria:

1. Anatomy is not appropriate for percutaneous valve implantation. Native valve annulus diameter is not in the scope of application(native TAV diameter ≤21mm, or ≥30mm);
2. Evidence of an acute myocardial infarction within 30 days prior to the study procedure, defined as: Q-wave myocardial infarction, or non-Q-wave myocardial infarction, with CK-MB≥2 ULN/or elevated TN (WHO definition);
3. Any treatment for traumatic cardiac surgery within 30 day prior to the study procedure(except coronary revascularization);
4. Pre-existing prosthetic valve in any position(except severely dysfunctional aortic bioprosthesis), or severe (\>3+) mitral insufficiency, or Gorlin syndrome;
5. Hematological abnormality, defined as: Leukopenia (WBC \<3x10\^9/L), acute anemia (Hb \<90g/L), or thrombocytopenia (platelet count\<50×109/L),history of bleeding diathesis or coagulopathy;
6. Hemodynamic unstable requiring myocardial contractile support or mechanical cardiac assistance;
7. Severe ventricular insufficiency. Left ventricular ejection fraction (LVEF) \<20%;
8. Echocardiographic evidence of intra-cardiac thrombus or vegetation etc.;
9. Active pepticulcer or upper GI bleeding within 3 months prior to the study procedure;
10. Cerebral Vascular Accident (CVA) within 3 months prior to the study procedure, including TIA;
11. A known hypersensitivity or contraindication to aspirin, heparin, ticlopidine or clopidogrel, or sensitivity to contrast media, which cannot be adequately pre-medicated;
12. Patients with infective endocarditis or other active stage of infection;
13. Currently participating in an investigational drug or another device trial.
The Efficacy of Claritin in Healthy Subjects

The primary goal of this study is to examine determinants of the efficacy of Claritin.

Subjects will be given Claritin 10mg tablet. Subjects will be challenged with histamine via skin prick prior to Claritin administration and at 1 and 2 hours post administration. We will measure and record wheal and flare area 10 minutes following each challenge.

Eligibility Criteria:
Inclusion Criteria.

1. Males and females between 18 and 65 years of age.

Exclusion Criteria.

1. Pregnant or lactating women.
2. Upper respiratory infection within 14 days of study start.
3. Women of childbearing potential not using specific contraception method(s) (i.e., birth control pills, depo Provera, double barrier) as well as women who are breastfeeding.
4. Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (heart, lung, kidney, neurological, oncologic or liver disease).
5. Use of any other investigational agent in the last 30 days.
6. Use of medications that may affect skin testing. Specifically, subjects are excluded if they have used an antihistamine during the 4 days preceding their treatment visit.
Engaging Patients in Tobacco Cessation Resources in Dental Settings

The overarching goal of this project is to reduce smoking-associated morbidity and mortality by increasing the number of patients who are referred for tobacco cessation counseling. Using a stratified, group-randomized, controlled, 2-arm trial conducted in two settings, the investigators will compare smoking-related clinical decision support (CDS) to usual care.

This project aims to reduce smoking-associated morbidity and mortality by increasing the number of patients who are referred for tobacco cessation counseling. The study team will evaluate the effectiveness of clinical decision support (CDS) to improve dental provider delivery of brief tobacco interventions and referrals to tobacco quitlines for further tobacco counseling. The CDS will generate personalized, evidence-based recommendations for dentists and dental hygienists to actively engage their smoking patients in the course of usual dental care. Subsequently, the study team will assess the tobacco cessation actions of smokers using patient-centered outcomes.

Eligibility Criteria:
DENTAL STUDENTS AND DENTAL HYGIENE STUDENTS

Inclusion Criteria:

* 3rd and 4th year predoctoral students or dental hygiene students enrolled at selected dental schools

PRIVATE PRACTICE DENTISTS \& HYGIENISTS

Inclusion Criteria:

* General practice dentists or dental hygienists practicing at selected private practice clinics

Exclusion Criteria:

* Providers not able or willing to record current tobacco use status in their electronic health record
* Providers affiliated with selected dental schools who hold a current teaching or clinical position

PATIENTS

Inclusion Criteria:

* Current cigarette smokers

Exclusion Criteria:

* patients requesting to opt out of research
Chemotherapy With or Without Surgical Resection in Locally Advanced Esophageal Cancer

In this randomized study, we plan to address the important question of optimum local treatment for patients with localized esophageal cancer. All patients will receive our previously studied neo-adjuvant regimen including paclitaxel, carboplatin, infusional 5-FU, and radiation therapy to 45 Gy. At the completion of neo-adjuvant therapy, patients will be randomized to undergo surgical resection, or to continue radiation to a total dose of 60 Gy, along with one additional course of chemotherapy.

Upon determination of eligibility, all patients will receive neo-adjuvant therapy with:

Paclitaxel + Carboplatin + 5-Fluorouracil + Radiation

After neo-adjuvant therapy and restaging are completed, patients will be randomized to receive one of two treatments:

* Surgical resection (Arm A)
* Paclitaxel + Carboplatin + Radiation (Arm B)

Eligibility Criteria:
Inclusion Criteria:

To be included in this study, you must meet the following criteria:

* Cancer of the esophagus or gastroesophageal junction confirmed by biopsy (squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma) clinical stage I, II, or III.
* Received no previous treatment for esophageal cancer.
* Measurable or evaluable disease
* Able to perform activities of daily living with minimal assistance
* Adequate bone marrow, liver and kidney function
* Be at least 3 weeks from any major surgical procedures.
* Have an indwelling central venous access catheter.
* Patients must be able to understand the nature consent of the study and give written informed consent.

Exclusion Criteria:

You cannot participate in this study if any of the following apply to you:

* Age \< 18 years
* History of a prior malignancy within the past 5 years
* History of significant heart disease
* Inoperable on the basis of co-existent medical problems

Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.