cyrilzakka/clinical-trials huggingface dataset:
Impact of Male Provider Phone Calls to Increase Men's Clinic Linkage After HIVST

Evaluate the impact of phone calls from a male counselor in increasing linkage to HIV care and PrEP among male partners of pregnant women attending PMTCT.

Evaluate the impact of phone calls from a male counselor in increasing linkage to HIV care and PrEP among male partners of pregnant women attending PMTCT. Approach: Leveraging the staff and infrastructure of an ongoing study, Kingasa (R01MH113434), this study will evaluate the impact of phone calls from a male counselor to encourage male partners to link to HIV care or prevention services after HIV testing. The intervention will provide male counselor follow-up to 100 male partners of pregnant women in the intervention arm of the Kingasa study. Exit interviews will be conducted with men and their female partners to assess acceptability and challenges associated with the intervention. Outcomes assessed include ART initiation among HIV-positive men and PrEP by HIV-negative men at 6 months.

Hypothesis: The intervention of a phone call from a male counselor to provide counseling and encourage linkage to HIV care or prevention will be feasible and acceptable. It will result in a higher proportion of men linking to treatment and prevention compared to the standard of care arm of the Kingasa pilot study.

Eligibility Criteria:
Inclusion Criteria for women:

Age ≥18 or 14-17 years if an emancipated minor (pregnant or have a child), Currently pregnant, Not currently enrolled in an HIV treatment study, Male partner not known to be HIV-positive or has not tested in the past 3 months, Able and willing to provide written informed consent, Able and willing to provide adequate locator information for study retention purposes, Screening negative for any indication of intimate partner violence or social harm

Inclusion Criteria for men:

Female partner enrolled in Kingasa pilot study.
A Prospective, Multicenter, Single Arm Feasibility Study of the Safety and Performance of GRADION™ Hip Total Cartilage Replacement (TCR)™ in the Treatment of Degenerative Joint Disease of the Hip

This is a prospective, multicenter, single arm feasibility study of the safety and performance of the GRADION™ Hip Total Cartilage Replacement (TCR)™ in patients who require cartilage replacement.


Eligibility Criteria:
Inclusion Criteria:

* Primary hip surgery for Noninflammatory Degenerative Joint Disease (NIDJD) such as osteo/degenerative arthritis, and is indicated for cartilage replacement
* Skeletally mature or at least 18 years of age and has normal anatomy
* Patient signs the Informed Consent form
* Failed medical management
* There will be size limitations on patients also - available size range is 46mm-54mm.

Exclusion Criteria:

* Allergic to polyether urethane, sodium polyacrylate, bone cement or any of its components
* Previous fusion, acute femoral neck fracture and/or above knee amputation
* Revision of any previous hip procedure
* Slipped capital femoral epiphysis (SCFE)
* Rheumatoid arthritis
* AVN
Inhalational Anesthesia and Precipitation of Dementia: is There a Link?

Many elderly patients undergoing surgical procedures already have impaired cognitive (memory/concentration) status. Patients with pre-existing cognitive impairment, or dementia, may benefit from modified anesthesia techniques. It is estimated that one in eight people age 65 and older has Alzheimers disease. More so, nearly half of people that are 85 years or older have Alzheimers disease. Currently, both spinal (regional) and inhalational (general) anesthesia, are used in patients undergoing common urological, orthopedic, and general surgical procedures. Inhalational anesthesia has been associated with higher risk of memory impairment in experimental (animal) and human studies. However, currently, there are simply no large or good enough studies to be sure that inhalational anesthesia is responsible for causing dementia and Alzheimers disease.The proposed study investigates if elderly patients (65 years and older) undergoing spinal anesthesia (patient is awake or slightly sedated) are less likely to develop dementia and Alzheimers disease for up to 2 years after surgery, when compared to inhalational anesthesia (patient is kept asleep with gas anesthetic). The investigators will also test all patients for the presence of apolipoprotein (ApoE-Îμ4 type of gene that is present in 15-20% of patients), and beta-amyloid tau protein (present in cerebrospinal fluid) that are known risk factors for Alzheimers disease. The particular strength of this study is that it takes into account whether the frequency and/or severity of dementia and Alzheimers disease is different in patients with and without these markers. The investigators believe that this study will make a major contribution to better understanding of development of Alzheimers disease.


Eligibility Criteria:
Inclusion Criteria:

* \>65 yrs of age
* Male or female
* Scheduled to undergo urologic procedures (e.g., transurethral resection of prostate, transurethral resection of bladder tumor), orthopedic (e.g., total knee replacement, total hip replacement) general (e.g., femoral hernia repair, lower abdominal surgery) or vascular surgery procedures (e.g. lower limb reperfusion amputations) and qualifies to be randomized to receive either local (spinal) or general anesthetic

Exclusion Criteria:

* Diagnosis of severe dementia
* Diagnosis of any other significant neurological disease such as Parkinson's, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic defaults or known structural brain or spinal abnormalities.
Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients

Angiographies of the supra-aortic vessels by magnetic imaging have become common recently. So it was the purpose of this study to evaluate the imaging potential of different contrast agents.

Three contrast agents for magnetic resonance imaging are compared in angiographies of the supra-aortic arteries in a intraindividual study of 10 patients.

All applications of these contrast agents are performed with a flow of 2 ml/s. One contrast medium is applicated a second time with a reduced flow of 1 ml/s.

The angiographies of the supra-aortic vessels are evaluated by two experienced readers in a consensus reading. The signal/noise- and contrast/noise-ratio of anatomic vessel segments of the carotic and vertebral arteries are measured and compared to each other.


Eligibility Criteria:
Inclusion Criteria:

* Headache
* Epilepsia
* Dizziness

Exclusion Criteria:

* Pregnancy
* Metal implants (e.g. pacemaker)
* Contraindication for contrast agent
* Multiple allergies
Effects of Microcurrent in a Cardiovascular Rehabilitation Home-based Program

The aim of this study was to investigate the effects of electric stimulation (electrolipolysis) in a home-based cardiovascular rehabilitation program in patients with acute myocardial infarction

Cardiovascular disease is the leading cause of death in most industrialized countries.

It is widely accepted that cardiac rehabilitation has a beneficial role in the control of modifiable cardiovascular risk factors. However, these cardiovascular rehabilitation programs are scarce and only a small fraction of the population who needs has access. So, it is pertinent to the displacement of these programs to the community context.

Obesity has become a truly global epidemic among children and adults, as well as changing the metabolic profile: when occurs an excessive accumulation of adipose tissue (mainly central distribution) there are a set of changes / adjustments to the cardiac structure and function. The electrical stimulation of abdominal subcutaneous (electrolipolysis) is a procedure often used in physical therapy clinics to reduce waist circumference. However, the effectiveness of this intervention, the selection of parameters, and the duration of its effects in cardiac patients are not yet clarified in the literature.

Eligibility Criteria:
Inclusion Criteria:

* Individuals admitted to the coronary care unit for acute myocardial infarction for more than one year;
* Individuals of both sexes;
* Ages between 40 and 75 years;
* Heart disease stabilized;
* Motivation to perform physical activity for 8 weeks;
* Cognitive level sufficient to understand the particulars of the study.

Exclusion Criteria:

* Contraindications of micro-current (pacemaker, osteosynthesis material, tumor areas and open wounds or skin changes in the abdominal region);
* Pregnant at the time, in the preceding 6 months or wishing to become pregnant during the intervention period;
* Neurological, musculoskeletal or respiratory disorders;
* Individuals who are to carry out other therapies.
The Effect of Laughter Yoga on Tex Anxiety and Educational Stress

The primary purpose of this study is to examine the effects of laughter therapy on tex anxiety and educational stress in 8th-grade students.


Eligibility Criteria:
The inclusion criteria of the study were determined as being an 8th-grade student, speaking and understanding Turkish, and being able to perform daily life activities.

The exclusion criteria of the study were to have undergone a surgical operation in the last three months, and to have uncontrollable blood pressure, diabetes and asthma.
Lifestyle Intervention in Obesity, Effect on Diabetes

There are evidence from numerous studies on effect of lifestyle intervention in morbidly obese patients with type 2 diabetes. This study examines the effect of the "Evje-model" on type 2 diabetes.

The "Evje-model" is a combined 12 months model, consisting of repeated stays in a specialist centre, telephone follow-up at home, home groups, self monitoring and close contact with the patients' local physician.

There will be done QOL-measures, blood- and urine analysis, weight, waist- and hip measurement, blood pressure and VO2-max measurement at baseline, after 6 months and after 12 months.

Eligibility Criteria:
Inclusion Criteria:

* All patients with BMI \> 35 with diagnosed type 2 diabetes
* Referred to Lifestyle Intervention from a public hospital

Exclusion Criteria:

* Pregnancy
* Active major psychiatric disease(s)
* Active and serious eating disorder
* Drug- and/or alcohol dependency
Penicillin Allergy in Shfayim Clinic

revising penicillin allergy in the medical records, by taking full medical history and giving a challange test, in order to imrove the medical records and treatment possibilities.

issuing a list of patients with a title of penicillin allergy in their medical record. inviting these patients to an appointmnet with their family physician, in which a specific history will be take to evaluate the quality of the allergy.

patients with suscpition of a life threatening allergic reaction will be reffered to an allergy clinic for the challange test. the rest of the pateints will be given the test in the primary clinic: 1ml (50 grams) of amoxicillin, and an hour later a full dose of 500 mg amoxicillin.

after determining no allergic reaction develops the title will be erased from the medical record.

Eligibility Criteria:
Inclusion Criteria:

penicillin allergy in the medical record

Exclusion Criteria:

pregnancy lack of informed consent
Long-term Functional Outcome of Children With Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD) are group of immune system disorders characterized by a chronic course with remission and relapses. Canada is one of the countries with the highest prevalence and incidence rates of IBD with 25% of patients present in children and adolescents.

As with any chronic illness, IBD diagnosed early in life has a significant impact on the physical, emotional and social development of those affected. Consequently, it is logical to speculate that patients with IBD may not do as well in education levels or employment status attained compared to their peers without IBD. If this were the case, then interventions could begin in childhood to better prepare patients with IBD for the challenges of living with a chronic disease. Alternatively, if it is shown that they reach comparable social or employment milestones as adults compared to unaffected peers then this would be enormously reassuring to children and their parents.

Properly designed studies to help in defining more appropriate interventions to these patients are needed.

The proposed study includes circulating a survey to evaluate the functioning level of adult patients with IBD who were diagnosed during their childhood. The participants will be asked a series of questions regarding their highest level of educational achievement, the nature of their current employment, and their current marital status. The question format will parallel that of the Canadian Community Health Survey from which data from an age matched healthy adult Manitobans will be extracted and used as another control group. Responses will be analysed for any possible differences between these groups.


Eligibility Criteria:
Inclusion Criteria:

* adult patients who were initially diagnosed with IBD in childhood or adolescence (diagnosis was made \< age of 18 years) and who were followed by the Section of Pediatric Gastroenterology at the Winnipeg Children's Hospital from 1974 - 2009.

Exclusion Criteria:

* Patients in whom the diagnosis of IBD was not fully established following the current North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines for diagnosing IBD i.e. had clinical, radiologic and endoscopic evidence of IBD (2).
* Control participants with other chronic debilitating diseases (e.g. malignancy, rheumatoid arthritis, multiple sclerosis, etc..) that may affect quality of life and functional outcome
Evaluation of Exotropia After Patching the Eye or After Prism Adaptation

This study intends to determine the number and percent of subjects initially diagnosed with divergence excess exotropia which would be reclassified as simulated divergence excess exotropia if tested after 24 hours of monocular occlusion (patching) or after prism adaptation for the distance angle.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with divergence excess exotropia according to standard criteria (see Study Procedures for specifics)
* No prior strabismus surgery
* Able to cooperate with testing (by examiner determination)
* Neurologically normal except for strabismus (ADHD and autism spectrum are not exclusion criteria as long as the subject can cooperate for necessary testing)
* Not amblyopic at the time of enrollment (best-corrected visual acuity in both eyes of 20/40 or better)
* Under 18 years of age. There is no lower age limit as long as the subject can cooperate for the required testing.
* No diagnosis of dissociated vertical deviation

Exclusion Criteria:

* No diagnosis of divergence excess exotropia according to standard criteria (see Study Procedures for specifics)
* Prior strabismus surgery
* Unable to cooperate with testing (by examiner determination)
* Diagnosed with a neurological disorder (ADHD and autism spectrum are not exclusion criteria as long as the subject can cooperate for necessary testing)
* Best-corrected visual acuity in either eye worse than 20/40
* 18 years of age or older
* Diagnosed with dissociated vertical deviation
Long-term Efficacy of Percutaneous Tibial Nerve Stimulation Applied to Patients With Faecal Incontinence.

Percutaneous tibial nerve stimulation (PTNS) is an ambulatory therapy validated for patients with Faecal Incontinence (FI) refractory to conservative treatment with proved short and mid-term efficacy.

The investigators therefore aimed to evaluate the long-term efficacy of PTNS, considered 3 years of follow-up. The investigators also aimed to identify predictors of responses and suggest a new approach for partial responders.

Prospective single-centre cohort of patients with FI treated with PTNS was analysed.

PTNS sessions were performed in three phases: weekly for three months in the first phase, biweekly for three months in the second phase, and monthly for six months in the third and final phase.

Clinical control at the end of each phase and an additional follow-up was performed at 36 months. Wexner score, faecal urgency, bowel habits and quality of life for FI were assessed.

Patients were categorized in three groups: optimal responders when there was an improvement in Wexner score \> 50%; partial responders if the improvement in Wexner score was 25-50%; and non-responders, when the improvement of Wexner score was \< 25%.

Optimal responders and partial responders progressed into successive phases, whereas non-responders abandoned PTNS and other treatment options were offered.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of faecal incontinence for more than 6 months, refractory to conservative treatment.

Exclusion Criteria:

* Anatomic injuries that require surgery.
* External anal sphincter lesion of \> 180º.
* Unavailability to attend regularly outpatient clinic.
* Major psychologic or psychiatric comorbidities
Sequential Therapy Versus Quadruple Therapy in H. Pylori Eradication

The investigators aimed to

1. compare the eradication rates and long term re-infection rates of sequential therapy for 14 days versus bismuth quadruple therapy for 10 days in the first line and second line treatment
2. assess the impact of antibiotic resistance and CYP2C19 polymorphism on the eradication rate of these regimens
3. assess the impact of these eradication regimens on the antibiotic resistance and microbiota of the gut flora
4. assess the impact of eradication therapy on the metabolic factors

Helicobacter pylori infection has been shown to be associated with the development of gastric cancer and peptic ulcer diseases. Eradication of H. pylori infection reduces the risk of gastric cancer and recurrence of peptic ulcer disease. However, the eradication rate of clarithromycin-based triple therapy has been declining in recent years, probably related to the increasing resistant rate to clarithromycin. Sequential therapy for 10 days has been shown to be more effective than triple therapy for 7 and 10 days. The investigators further demonstrated that sequential therapy given for 14 days was superior to triple therapy given for 14 days. Recently, the investigators also found that bismuth quadruple therapy given for 10 days appeared to be more effective than triple therapy given for 14 days in the first line therapy. However, whether sequential therapy given for 14 days is more effective than bismuth quadruple therapy or triple therapy for 14 days remains unknown.

Eligibility Criteria:
Inclusion Criteria:

1. H. pylori infected patients naïve to eradication therapies will be eligible in this study.

Exclusion Criteria:

1. children and teenagers aged less than 20 years,
2. history of gastrectomy,
3. gastric malignancy, including adenocarcinoma and lymphoma,
4. previous allergic reaction to antibiotics (bismuth, amoxicillin, metronidazole, clarithromycin, tetracycline) and PPI (esomeprazole),
5. contraindication to treatment drugs,
6. pregnant or lactating women,
7. severe concurrent disease,
8. concomitant use of clopidogrel, or (9) Unwilling to accept random assignment of subjects
A Multicenter Prospective Study to Assess the Effects of Adjuvant Icotinib in EGFRm Stage I NSCLC With High-risk of Disease Recurrence After Complete Resection

This is a multicenter single arm study, with an aim to assess the effects of adjuvant icotinib among EGFR mutant stage I lung adenocarcinoma patients, who have high-risk pathological features of recurrence.


Eligibility Criteria:
Inclusion Criteria:

* Male or female, at least ≥ 18 years，and ≦ 80 years
* Lung adenocarcinoma.
* Stage I disease(IA or IB), based on TNM8 classification.
* There is at least one of the following high-risk factors:

  1. pathologically confirmed vascular invasion positive;
  2. pathologically confirmed lung adenocarcinoma containing solid or micropapillary or complex gland histology, with a percentage \> 20%;
  3. pathologically confirmed invasive tumor size \> 2 cm;
  4. pathologically confirmed visceral pleural involvement (T2a).
* Started adjuvant therapy in this study 4-6 weeks after complete resection without any previous antitumor therapy.
* A tumour which harbours one of the 2 EGFR mutations (Ex19del, L858R) ,without KRAS mutation
* World Health Organization performance status of 0 or 1.
* Bood routine: HB \> 80g/L; ANC \> 1.0x109/L; PLT \> 50x109/L.Blood biochemistry： ALT and AST \< 2.5 times the upper limit of normal; Crea \< 1.5 times the upper limit of normal.
* Good adherence to follow-up.
* During the trial and for 3 months after the trial，Participants must be using highly effective contraceptive measures.

Exclusion Criteria:

* Prior treatment with any anticancer therapy for NSCLC (including chemotherapy, radiotherapy, immunotherapy, and EGFR-TKIs).
* Local radiotherapy.
* Patients with cancers other than NSCLC (except cured cervical carcinoma in situ, cured basal cell carcinoma and bladder epithelial tumors) within 5 years prior to the start of treatment in this study.
* Any unstable systemic disease (including active infection, uncontrolled hypertension, unstable angina, angina pectoris beginning within the last 3 months, congestive heart failure, myocardial infarction occurring within 6 months prior to enrollment, severe arrhythmia requiring medication, liver, kidney or metabolic disease).
* Any clinical evidence suggestive of active interstitial lung disease.
* An eye inflammation or eye infection that is not fully controlled, or any condition that could lead to one of these eye conditions.
* Known human immunodeficiency virus (HIV) infection.
* Known hypersensitivity to EGFR-TKI drugs or related components.
* Mixed small cell and non-small cell cancer history.
* Substance abuse, or illnesses such as psychological or psychiatric disorders that may interfere with study compliance.
* Patients with epilepsy requiring medication (e.g. steroids or anti-epileptic drugs).
* Other conditions deemed unsuitable for enrollment by the investigator.