Boron Neutron Capture Therapy Following Surgery in Treating Patients With Glioblastoma Multiforme Removed During Surgery

RATIONALE: Boron neutron capture therapy may selectively kill tumor cells without harming normal tissue.

PURPOSE: This phase I trial is studying the side effects and best dose of boron neutron capture therapy following surgery in treating patients with glioblastoma multiforme removed during surgery.

OBJECTIVES:

* Determine systemic and local toxicity of borocaptate sodium with boron neutron capture therapy (BNCT) following craniotomy with gross total resection in patients with glioblastoma multiforme.
* Determine the qualitative and quantitative dose-limiting toxicity and maximum tolerated dose of this regimen in these patients.
* Determine the maximum tolerated radiation dose of BNCT in cranial localization to healthy tissues in these patients under defined conditions.

OUTLINE: This is a dose escalation, multicenter study.

Within 6 weeks of surgery, patients receive borocaptate sodium followed 12-18 hours later by neutron irradiation. Treatment repeats daily for 4 days.

Cohorts of 3-9 patients receive escalating doses of neutron irradiation. The maximum tolerated dose is defined as the dose preceding that at which 3 or more patients experience dose limiting toxicity.

Patients are followed weekly for 4 weeks, monthly for 2 months, every 6 weeks for 15 months and then every 3 months thereafter.

PROJECTED ACCRUAL: Approximately 30-36 patients will be accrued for this study.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Histologically proven glioblastoma multiforme for which conventional radiotherapy would be of little or no benefit
* Gross total resection of tumor confirmed by postoperative MRI performed within 48 hours of surgery
* Evaluable preoperative and postoperative MRI films with and without contrast must be available
* No prior brain malignancy
* No prior craniotomy except for glioblastoma

PATIENT CHARACTERISTICS:

Age:

* 50 and over

Performance status:

* Karnofsky 70-100%

Life expectancy:

* Not specified

Hematopoietic:

* Not specified

Hepatic:

* Bilirubin, SGOT, SGPT, and alkaline phosphatase no greater than 2.5 times normal unless caused by reversible reaction to antiseizure medication

Renal:

* Blood urea nitrogen and creatinine no greater than 2.5 times upper limit of normal

Cardiovascular:

* No severe heart disease (e.g., congestive heart failure, angina pectoris)

Pulmonary:

* No severe dyspnea at time of diagnosis
* No severe obstructive or restrictive lung disease

Other:

* No other concurrent malignant tumor
* No severe gastrointestinal disease or active peptic ulcer disease
* No uncontrolled endocrine disease
* No serious mental disease, organic brain disease (e.g., preexisting epilepsy or serious aphasia), or legally incapacitated patients

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No prior biologic therapy for glioblastoma multiforme
* No concurrent biologic therapy

Chemotherapy:

* No prior chemotherapy for glioblastoma multiforme
* No concurrent chemotherapy

Endocrine therapy:

* No prior endocrine therapy for glioblastoma multiforme except corticosteroids
* No concurrent endocrine therapy

Radiotherapy:

* See Disease Characteristics
* No prior radiotherapy for glioblastoma multiforme
* No prior radiotherapy to head and neck
* No other concurrent radiotherapy

Surgery:

* See Disease Characteristics
* Prior stereotactic biopsy allowed for glioblastoma multiforme