cyrilzakka/clinical-trials huggingface dataset:
Effectiveness of Theobromine Toothpaste

Since plaque control forms the basis for caries prevention, the type of toothpaste and its constituents becomes more important.

Toothpaste containing fluoride are widely popular and fluorides have been historically reported to have effects against dental caries. However, the fluoride safe doses are still discussed ,because fluoride has toxicity and causing fluorosis.

The aim of the current research is to find alternative agent that can be used without side effects.

Participants will be examined to ensure that they have met the smple entrey criteria,then the participants will be randomly assigned to four groups each one according to a group:

1. A group of children using low-fluoridated toothpaste (500ppm)
2. A group of children using fluoridated toothpaste (1450ppm)
3. A group of children using theobromine toothpaste (2%)
4. A group of children using low-fluoridated toothpaste (4%) The researcher will teach the participants how to brush using (tell-show-do)technique.

   * The brushing method that will be used is the fones technique.
   * Brushing duration must be 2minutes.
   * Frequency of brushing must be twice a day
   * The amount of toothpaste used is pea size.

Mechanism of examination and follow up:

A thorough scaling and plaque removal was conducted and the children were advised to brush their teeth using their regular toothpaste for a week before starting the research.

Gingival will be evaluated with gingival index (loe and silness)

Eligibility Criteria:
Inclusion Criteria:

* Children of age group 6to 9 years.
* Participant must have least 20 teeth free from dental cries on both buccal and lingual surfaces of the teeth.
* Cooperative children having behavioral rating (positive or definitively positive)according to frankel's behavior rating scale.
* Children who are not on any medication prior or during the study period

Exclusion Criteria:

* children with systemic diseases and medically compromising conditions.
* children undergoing orthodontic treatment or with an intraoral prosthesis.
* children who could not brush their teeth or rinse on their own.
* Allergic to any of the toothpaste ingredient used the study.
Clinical, Radiographic and Laboratory Analysis of Failures of Joint Replacements

The purpose of this study is to more fully understand the reason(s) that joint replacement implants fail and to better identify diagnosis and outcome methods both pre-operatively and post-operatively with revision surgery. Analysis of joint replacement failure will include a through analysis of laboratory, radiographic, implant, surgical and demographic data.

To examine all clinical data in patients with failed total hip and total knee replacements including patient demographics (age, sex, comorbidities, etc.), patient clinical data (history and physical exam and lab findings) and including implant specifications and radiographic findings (for implant type, implant size, implant bearing surface type, position, stability, etc.).

Eligibility Criteria:
Inclusion Criteria:

* ≥18 years of age
* failed hip or knee replacement
* willing to sign informed consent

Exclusion Criteria:

* none
Exome Sequencing in Autistic Spectrum Disorder

Background:

* Research into the genetic causes of autism spectrum disorder (ASD) involves studies of the DNA of children with autism. New DNA sequencing technology allows researchers to study specific genes in search of genetic changes that may cause or contribute to ASD. Individuals who donated DNA to the Autism Genetic Resource Exchange may benefit from further study of their DNA samples with more advanced DNA sequencing technology.
* The role of cholesterol in individuals with ASD is currently under investigation. Research has suggested that abnormal cholesterol levels in children with autism may be related to genetic mutations or changes in how cholesterol is regulated in the body.

Objectives:

- To study existing blood samples of children with autism spectrum disorders to evaluate the relationship between genetic traits and cholesterol function.

Eligibility:

- Children with ASD who donated blood samples to the Autism Genetic Resource Exchange.

Design:

* Parents/guardians of minor children with ASD will provide consent for further research to be performed on existing DNA samples in the Autism Genetic Research Exchange databank. Information from this research may be provided to the consenting parents/guardians on a case by case basis, as directed by the researchers.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by functional deficits in three domains: social interaction, communication, and stereotypic behavior. Prevalence has been estimated to be approximately 1/166 children and the public health impact is significant. ASD clearly has a genetic component; however, identification of specific etiologies has been complicated by the heterogeneous nature of ASD. One approach to minimize this problem is to define endophenotypes that can subcategorize ASD patients. Based on our work with Smith-Lemli-Opitz syndrome, we have investigated whether alterations in cholesterol homeostasis may contribute to ASD. We found in 200 ASD subjects that 23% of subjects had serum cholesterol levels less than or equal to 2.28th centile and 9% had levels greater than or equal to 97.72nd centile. Analysis of the sterol profile suggested that the hypocholesterolemia was due to a synthetic defect rather than decreased oral intake. Thus we hypothesize that ASD patients with abnormal cholesterol levels will have polymorphisms or mutations of either genes involved in cholesterol homeostasis or genes encoding proteins whose function is altered by changes in cholesterol levels. To test this hypothesis we propose to 1) use serum cholesterol levels to define ASD endophenotypes and 2) to perform genomic resequencing of all known exons in hypo- and normocholesterolemic ASD patients.

Eligibility Criteria:
* INCLUSION CRITERIA:

  1. Prior participation in Autism Genetic Research Exchange
  2. Multiple affected children with ASD
  3. Willingness to contact the NIH and reconsent
Effect of Scapular Stabilization Excercise With Pectoralis Minor Stretching in Ballers Having Scapular Dyskinesia

The study is randomized and single -blinded. Ethical approval is taken from ethical committee of Riphah International university Lahore. participant selected through non probability convenience sampling technique on 26 fast bowlers which further players were randomly divided into two groups, group A (Experimental group) and group B (Control group), having 13 players in each group. Scapular stabilization exercises along with pectoralis minor stretching were administered in group A whereas generalized shoulder exercises along with self-stretching of shoulder muscles were performed in group B.

It will be randomized controlled trial (RCT) research design at AL Fatah sports complex and Saeed Ajmal cricket academy through non probability convenience sampling technique on 26 fast bowlers which further players were randomly divided into two groups, group A (Experimental group) and group B (Control group), having 13 players in each group. Scapular stabilization exercises along with pectoralis minor stretching were administered in group A whereas generalized shoulder exercises along with self-stretching of shoulder muscles were performed in group B. Assessment will be made by pocket radar, pectoralis minor index and Vernier caliper. There will be 3 sessions in a week for 6 weeks. The baseline scoring will be on 1st day, follow up will be taken at 6th week. Data will be analyzed during SPSS software version 26. After assessing normality of data by Shapiro-Wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility Criteria:
Inclusion Criteria:

Male fast ballers

* 21-30 years of age
* Duration of playing at least 1 to 2 years
* Dominant side effected

Exclusion Criteria:

* • Old fracture at effected arm

  * Any serious injury during treatment
  * Patient with cervical spondylosis and neurological abnormalities at effected arm
Hyaluronidase in Intra-articular Steroid Injection Treating the Adhesive Capsulitis for Shoulder

Adhesive capsulitis (AC) is painful and disabling condition that is associated with a gradual loss of shoulder motion. Intra-articular steroid injection is a common treatment in the initial painful stage of AC, and its use in combination with hyaluronidase may offer increased therapeutic efficacy owing to synergistic effects. We determined the therapeutic efficiency of the co-administration of hyaluronidase in early AC by evaluating symptomatic, anthropometric, and imaging changes.

We enrolled eligible patients with primary adhesive capsulitis in the initial stage.The subjects were randomly assigned into 3 groups to receive ultrasound-guided intra-articular injections with 20 mg (group A) and 40 mg triamcinolone acetonide (group B) and 20 mg acetonide combined with hyaluronidase (group C). The outcome measures included the visual analogue scale (VAS), the shoulder disability questionnaire (SDQ), abduction and external rotation range of motion, and intra-sheath fluid (ISF) before treatment and at 2, 4, 8, and 16 weeks after treatment.

Eligibility Criteria:
Inclusion Criteria:

* Normal findings on simple x-rays of the shoulder but limitations in passive range of motion on physical examination
* Increased intra-sheath fluid (ISF) sufficient to encircle the long head of the biceps tendon within the upper portion of the bicipital groove of the humerus.

Exclusion Criteria:

* Ultrasonographic diagnosis of other concomitant fundamental abnormalities causing shoulder pain such as rotator cuff tear, bicipital tendon rupture, calcific tendinopathy, and subacromial-subdeltoid bursitis
* A history of shoulder injury
* A history of more than 1 year of conservative treatment for chronic shoulder pain
* Corticosteroid or hyaluronidase injections within the prior 6 months
* Hemiplegic shoulder
* Self-reported history consistent with scapula fracture or disarticulation
* Ipsilaterally cervical herniated intervertebral disc or brachial plexus injury
* Diabetes mellitus refractory to insulin therapy or glycated hemoglobin greater than 6.5
* Refusal to participate in this study
Amino Acid Balance During Physical Inactivity

The aim is to assess the impact of physical inactivity on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding will modulate muscle amino acid balance and forearm glucose uptake.

The aim is to assess the impact of forearm cast immobilization on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding during immobilization will modulate muscle amino acid balance and forearm glucose uptake.

Eligibility Criteria:
Inclusion Criteria:

* BMI between 18 and 30

Exclusion Criteria:

* Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes).
* Any diagnosed cardiovascular disease or hypertension.
* Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements.)
* Chronic use of any prescribed or over the counter pharmaceuticals.
* Regular use of nutritional supplements (e.g. creatine, protein supplementation)
* Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
* A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
* Any previous motor disorders.
Adderall XR and Processing Speed in Multiple Sclerosis (MS)

Cognitive impairment, or problems with thinking and memory, is common in multiple sclerosis (MS) and can occur independently of physical disability. It is the most common reason, along with physical fatigue, for MS patients to stop working. The most frequent complaint is problems with multi-tasking or thinking quickly, which corresponds to impairment in the cognitive domain of processing speed. Currently there is treatment available to prevent relapses and physical disability but there are no medications that have been shown to treat cognitive impairment. Amphetamines have been beneficial for selective attention and processing speed in attention deficit hyperactivity disorder (ADHD) and traumatic brain injury. This is study will determine whether Adderall XR improves objective measures of processing speed and attention in MS patients impaired in this cognitive domain, by comparing two doses of Adderall XR (5 and 10mg) to placebo before and after the medication is administered. The results of this study will help provide data to design a larger study to determine if Adderall XR, and potentially other amphetamine drugs, will help treat cognitive impairment in MS patients.


Eligibility Criteria:
Inclusion Criteria:

* - Males/Females who are ≥ 18 years old and ≤ 59 years old
* Relapsing Remitting, Secondary Progressive or Primary Progressive MS, as per revised McDonald's Criteria
* Have not received corticosteroids in last thirty days or a relapse in the last ninety days
* An Expanded Disability Status Scale (EDSS) of ≤ 6.5
* If female, must neither be pregnant nor breast-feeding

Exclusion Criteria:

* - Have evidence of other medical cause(s) of cognitive impairment
* Have evidence of major depression as determined by a positive Beck Depression Index-Fast screen ≥ 13and/or by clinician interview or evidence of severe fatigue with a Fatigue Severity Scale ≥ 5.
* Have demonstrated a hypersensitivity to amphetamines in the past
* Have uncontrolled or labile hypertension (\> 135/85 mm Hg, treated or untreated)
* Have a history of structural heart disease, including atherosclerosis or angina
* Have a diagnosis of bipolar disorder or a history of a psychotic episode
* The following medications are not permitted to be used within 14 days the study

  1. Monoamine Oxidase Inhibitors
  2. Sympathomimetics or methadone
  3. Antipsychotic agents
  4. Modafinil
* The following medications are permitted if the dose has been stable for ≥ 28 days

  1. Short acting benzodiazepines, qhs administration only
  2. Anticonvulsants, including gabapentin and pregabalin
  3. Bupropion
  4. Tricyclic Antidepressants
  5. Anti-spasmodics such as baclofen or tizanidine
  6. Anticholinergic medication
  7. Selective serotonin(-norepinephrine) reuptake inhibitors
Development and Application of Rapid Nucleic Acid Diagnostic Kits for Clinical Specimens

The purpose of this study is to study the Development and Application of Rapid Nucleic Acid Diagnostic Kits for Clinical Specimens. Subjects are divided into two groups which are health group and Tuberculosis or lung cancer group in order to compare with the difference.


Eligibility Criteria:
Inclusion Criteria:

* Health group: between 17 to 90 years old
* Tuberculosis group: people who are tuberculosis or lung cancer patients and between 17 to 90 years old

Exclusion Criteria:

* Women subjects are before or after the period within two days
Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer

The purpose of this study is to investigate whether TAC plus FOLFOX4 or TACE plus folfox4 are able to improve resection rate and overall survival in patients receiving primary colorectal tumor resection than given FOLFOX4 only.

We administered three cycles FOLFOX4 plus TAC(oxaliplatin,FUDR and MMC) or FOLFOX4 plus TACE(oxaliplatin,FUDR,MMC and embolision) to primary colorectal tumor resected patients with unresected liver metastasis. The study endpoints were resection rate of liver metastasis, progression-free survival, overall survival as evaluated by intent-to-treat analysis.

Eligibility Criteria:
Inclusion Criteria:

* age \< 75 years with histologically proven adenocarcinoma of the colon or rectum
* no severe major organ dysfunction
* WHO performance status of 0 or 1
* no prior cancer therapy
* with measurable unresectableliver metastasis
* without other metastasis

Exclusion Criteria:

* age \>= 75
* severe major organ dysfunction
* WHO performance status of \>1
* prior cancer therapy
* with other metastasis
Reducing HIV Risk Among Mexican Youth

The broad objective of this project is to test the efficacy of a theory-based HIV risk-reduction intervention, which includes both an adolescent component and parental component, designed to reduce the adolescents' risk of sexually transmitted HIV.

Sexually transmitted HIV infection among adolescents is a growing and significant problem in Mexico. Given the high mortality rate associated with AIDS, the lack of available treatment, and the social stigma associated with the disease, prevention is the key to reducing the threat of AIDS among this important subgroup in Mexico. The study has four specific aims including 1) to determine whether the HIV risk-reduction intervention causes a greater increase in adolescents' intentions to abstain from intercourse and/or avoid unprotected intercourse at post-intervention and decreased self-reported intercourse and unprotected intercourse at 3, 6, 12, and 48 month follow-ups, compared with the general health promotion control intervention; 2) to determine whether the effects of the intervention are moderated by individual, microsystem, and macrosystem variables; 3) to identify theory-based variables that mediate effects of the HIV intervention on adolescents' self-reported behavior; and 4) to determine whether the HIV risk-reduction intervention causes a greater increase in parents' comfort with, and quantity of communication (general and HIV specific) with adolescents at post-intervention, 3, 6, 12, and 48 month follow-up compared with the general health promotion control intervention.

Eligibility Criteria:
Inclusion Criteria:

* Families (adolescents \[aged 14 to 17 years of age\] and one of their parents)
Possible Role of Gingival Crevicular Fluid Levels of Chemerin and Fibroblast Growth Factor 21 as Biomarkers of Periodontal Disease in Diabetic and Non-diabetic Patients

The current study aims to spot the light on the possible role of gingival crevicular fluid (GCF) level of Chemerin and FGF21 to study their potential role as biomarkers of periodontal disease and to understand their role in the link between periodontitis and diabetes .

The study will be conducted on three groups; group (A) include fifteen controlled T2 DM patients suffering from periodontitis, group (B) include fifteen patients suffering from periodontitis alone, and group C) include fifteen periodontally and medically healthy individuals. GCF samples will be collected from all participants for assessment of Chemerin and FGF 21. Samples will be analysed using ELISA technique.


Eligibility Criteria:
Inclusion Criteria:

* age range between 35 and 60 years
* a minimum of 20 natural teeth.
* Type 2DM patients exhibiting HbA1c 6-8% and FPG ≥126 mg/dL for more than one year who did not complain of any systemic diseases other than t2DM
* periodontitis patients with moderate to severe periodontitis having gingival index GI ≥ 1, probing depth PD ≥ 5, and clinical attachment level CAL ≥ 4 mm, and bone loss affecting \> 30% of existing teeth on clinical/radiographic examination

Exclusion criteria

* uncontrolled diabetes mellitus
* systemic diseases which may affect the biomarkers levels and the periodontal conditions.
* Exposure to steroid therapies, radiation/immune-suppressive therapies.
* Allergic reaction to any kind of drug.
* Smoking over the past 5 years.
* Periapical pathologies.
* Exposure to mechanical forces as a result of occlusion/ orthodontics.
* History of periodontal or drug therapies within the previous 6 months.
CYP2D6 Pharmacogenetics in Risperidone-Treated Children

Risperidone is an important medication used to treat children with psychiatric illnesses or neurodevelopmental disorders, such as autism. Despite excellent symptom control, the potential for side effects is worrisome. Treating these disorders is difficult because not everyone responds the same way to the same risperidone dose. One reason for this is genetic differences in how people break down the drug. Understanding these differences will help clinicians choose a dose and better predict the response so patients will be treated successfully with a lower risk for side effects. This study will research these genetic differences in children with psychiatric or neurodevelopmental disorders. Hypothesis: The inter-patient variability in risperidone pharmacokinetics and exposure, adverse events, and clinical response in patients with psychiatric or neurodevelopmental disorders is associated with identifiable pharmacogenetic factors, such as CYP2D6 single nucleotide polymorphisms (SNPs).


Eligibility Criteria:
Inclusion Criteria:

* Previous risperidone PK study participation (CCHMC, Rainbow Babies and Children's Hospital or OSU)
* CYP2D6 PM predicted phenotype
* Actively taking risperidone
* Under 18 years of age at time of enrollment
* Signed, dated informed consent forms

Exclusion Criteria:

* Investigators are unable to contact the subject/legal guardian(s)
* Subject is no longer taking risperidone
* CYP2D6 predicted phenotype other than PM
* Subject is non-White, with respect to race, for PK study participation
* Subject is 18 years of age or older
* Subject is less than 5 years of age
* Subject is pregnant at the time of the full PK study
* Subject/legal guardian unwilling or unable to participate in the study
Multicountry Studies on the Effect of Positional Distribution of Fatty Acids at Triglyceride Backbone on Serum Lipids, Lipoprotein(a) and LDL-subclasses in Healthy Malaysian Volunteers

Fats and oils are made up of \>90% triacylglycerol fat molecules which consist of a glycerol backbone to which 3 esterified fatty acids are attached. The positions of fatty acid attachment are referred to by stereospecific numbers, sn -1, -2 and -3. There is existing evidence to show that vegetable oils having unsaturated fatty acids in the sn-2 position with predominantly palmitic acid (16:0) or stearic acid (18:0) in the sn-1 and sn-3 positions of fat molecules do not raise serum cholesterol levels. These observations have come to be known as or explained by the "sn-2 hypothesis". New evidence have also emerged to show that saturated fatty acids (16:0, 18:0) in the sn-1 and -3 positions reduces fat deposition in a rat model. In this proposed study, the effects on the outcome measures investigated of three test fats \[namely palm olein IV64 (POP), virgin olive oil (OOO) and cocoa butter (POS)\], with oleic acid primarily at the sn-2 position but differing amounts of palmitic, stearic and oleic acids at the sn-1/sn-3 positions of the triglyceride molecule, are investigated

To investigate the effects of different dietary fats with primarily oleic acid in the sn-2 position on the cardiovascular risk profile in healthy Malaysian volunteers

Eligibility Criteria:
Inclusion criteria:

* Healthy adult male or female, aged 20-50 years
* BMI 18.5- 24.9 kg/m2 as per WHO Classification (1998)

Exclusion criteria:

* Hyperlipidemia (TC\>6.2 mmol/L, TAG \>2.0 mmol/L)
* History of chronic disease- type 2 DM, heart disease, cancer
* Habitual smokers (\>2 sticks a day)
* Hypertensives: \>140/90 mmHg
* On medication/nutraceuticals to reduce blood lipids, blood pressure
* Pregnant or lactating women
* Planned trip abroad/overseas during period of study
Follow on Study From RE-ALIGN

To collect additional data relating to safety and indicators of efficacy for patients who have participated in the 1160.113 study.


Eligibility Criteria:
Inclusion criteria:

1. Completed study 1160.113 per protocol
2. Continuing need for anticoagulation

Exclusion criteria:

1. uncontrolled hypertension
2. severe renal impairment
3. active liver disease
4. increased risk of bleeding