cyrilzakka/clinical-trials huggingface dataset:
PERFUSION INDEX, PRONE ,SUPİNE AND SITTING POSITION

The aim was to investigate the effect of anesthesia management on perfusion index changes in obese patients and different anesthesia positions. The effect of positional intra-abdominal pressure and lung-related variables was investigated.

There may be changes in haemodynamic findings in patients after anaesthesia. The most common of these are hypotension and bradycardia. Many factors play a role on the hypotensive effect of anaesthesia induction1 . Position changes in patients during surgery in obese patients affect these changes.In our study, the changes in haemodimaic findings and the changes in PI and PVI were investigated in patients with BMI 30 and above and in patients with BMI within normal limits after induction of anaesthesia by giving prone position and sitting position.Position changes in patients during surgery in obese patients affect these changes. Hypertension and hypotension after induction of anaesthesia are common in obese patients. In addition, decreased venous return to the heart due to increased intrathoracic pressure during mechanical ventilation may trigger bradycardia and hypotension.

Eligibility Criteria:
Inclusion Criteria:

* 18-70 years range
* Patients who will be operated in supine prone and sitting positions

Exclusion Criteria:

* Heart Failure
* antiarrhythmic drug use hemodynamic instability uncooperative patients
Hypersensitivity Reactions to Propofol in Children

The investigators would only include the children who received propofol (Propolipid, Fresenius Kabi, Schelle, Belgium) for sedation, the investigators would exclude the children that didn't receive propofol during the procedure.

The investigators would analyze the incidence of hypersensitivity reaction to propofol in children allergic to egg, soy or both egg and soy and to compare those with the incidence of hypersensitivity reactions in children without allergy to egg and/or to soy. Those data were retrieved following longitudinal follow-up after the intervention. Allergy tests by skin and radioallergosorbent tests were performed in all children before the gastrointestinal endoscopy under anesthesia took place, but no results were known at the time of the sedation. A patient was defined as allergic to egg and/or soy if the patient had specific S-IgE level more than the normal level set by our institution (0.35 kU/L).

The investigators would also investigate the influence of other obtained parameters in the dataset (age, ASA score, weight category, type of investigation, respiratory and neurological comorbidities, respiratory infections, GERD, other allergies) on those results with multivariate analysis.

We considered that clinical features suggesting a hypersensitivity reaction present during anaesthesia were cutaneous, respiratory or cardiovascular manifestations. Depending on the severity of the reaction, necessitating prompt hemodynamic resuscitation with the administration of epinephrine, antihistamines, inhaled beta-agonists or corticosteroids.


Eligibility Criteria:
Inclusion Criteria:

* diagnostic gastrointestinal endoscopy
* monitored anesthesia
* received propofol during the procedure
* allergic to egg and/or soy if the patient had specific S-IgE level more than the normal level set by our institution (0.35 kU/L)

Exclusion Criteria:

* Procedure without administration of propofol
Transitional Care Study 3

In this study patients with elective surgery will wear two devices (HealthDot and Elan) after surgery in hospital and after discharge at home for up to 2 weeks (HealthDot) or 3 weeks (Elan). The HealthDot will measure heart rate, posture, activity and respiratory rate which are stored on the device as well as sent to Philips. The Elan device will measure PPG and accelerometer data which is transferred to Philips. The data collected will be used for algorithm development. Data will be analysed retrospectively and compared to readmission and adverse events to see if the events could have been predicted due to the collected data by the devices. No clinical decisions will be based on the measurements done during the study.


Eligibility Criteria:
Inclusion Criteria:

* Adult
* Willing and able to sign informed consent form
* Willingness to abstain from visiting a sauna during the study period
* Willingness to dry area where the HealthDot is applied in a dipping fashion after washing
* Willingness to abstain from flying during the study period of time
* Elective surgery
* General anesthesia required for surgery

Exclusion Criteria:

* General inmates of psychiatric wards, prisons, or other state institutions
* Investigator or any other team member involved directly or indirectly in the conduct of the clinical study
* Any skin condition, for example prior rash, discoloration, scars or open wounds at the area of investigation of both devices
* Pregnant, or breastfeeding
* Known to be allergic for the tissue adhesive used in the HealthDot.
* Use of topical that is known to influence the skin at the test area (such as medical and non-medical creams or lotions)
* Patient with active implantables such as Implantable Cardioverter Defibrilator (ICD) and pacemaker
* Unable to understand instructions
* Expected participation less than 2 weeks
* Left lower rib (place where HealthDot will be applied) is involved in the area of surgery, area of disinfection or area where bandages are needed.
* Area on arm where the Elan device is applied is involved in the surgical procedure.
* Patients with antibiotic resitant infections (e.g. MRSA).
An Extension Study of V203-AD Study to Evaluate the Safety, Tolerability, Immunogenicity, and Efficacy of UB-311

To evaluate the long-term safety, tolerability and potential efficacy, patients who previously participated in V203-AD study (NCT02551809) will be eligible to participate in the extension study and will receive 3 or 5 doses of UB-311 within a 96-week treatment period followed by a 12-week follow-up period.


Eligibility Criteria:
Inclusion Criteria:

* Patients who participated in V203-AD trial without major safety concerns;
* Stable doses of permitted medications for 3 months before screening;
* With a caregiver;
* Other inclusion criteria apply

Exclusion Criteria:

* Clinically significant neurological disease other than Alzheimer's disease
* Major psychiatric disorder
* Severe systemic disease
* Serious adverse reactions to any vaccine
* Other exclusion criteria apply
Effects of Modified T'ai Chi on Symptoms in Older Adults With Osteoarthritis

The purpose of this study was to evaluate the effects of TC for Arthritis on physical function, pain, and stiffness in older adults with knee/hip OA. Two hypotheses were tested:

1. Individuals in the TC group will demonstrate greater improvements in physical function compared to control group participants.
2. Individuals in the TC group will demonstrate greater decreases in pain and stiffness compared to control group participants.

Exercise is considered a vital component of osteoarthritis (OA) treatment. T'ai Chi (TC) is a unique exercise intervention with low-velocity movements. Few studies have addressed the effects of TC on arthritis symptoms and function. TC for Arthritis was modified specifically for people with OA and consists of a standardized set of forms.

The purpose of this study was to evaluate the effectiveness of a low-dose TC for Arthritis on physical function, pain, and stiffness in individuals with OA.

Twenty-seven older adults with OA (mean age-81.3 years) completed an 8 week non-randomized controlled pre-post test quasi-experimental design study of TC for Arthritis. Physical function, pain, and stiffness were measured at baseline and 8 weeks for the TC and control groups using the WOMAC™ 3.1 Index. Qualitative data from interviews and participant observations were analyzed in order to understand the participants' expectations and experiences with TC.

Eligibility Criteria:
Inclusion Criteria:

* Ability to walk independently,
* Speak and understand English,
* Understand the consent process; and
* Give informed consent.

Exclusion Criteria:

* Participation in rehabilitation or another TC class,
* At the time of recruitment; and
* Inability to confirm medical stability for safe participation with healthcare provider.
Provision of Service of a YQL Programme For Youth Smokers

This project is funded by Department of Health. We will run a quitline which provides telephone smoking cessation counseling to youth smokers aged 25 or below. After baseline counseling based on trans-theoretical model, follow-up counseling will be provided by trained counselors (i.e. nursing students or students from other healthrelated disciplines) at 1 week, 1, 3, 6, 9 and 12 months. It is expected that the quitline can assist youth smokers to quit smoking, thus saving the healthcare cost attributed to smoking in long-term.

This project will last for 15 months (from 1st Dec 2020 to 28th Feb 2022). Prior to commencement, a month will be spent on preparation, including setting up the quitline and website, designing and printing publicity materials, connecting with secondary and post-secondary schools and training peer counsellors. We will operate the quitline for 15 months and provide telephone counselling for eligible youth smokers. Self-reported quitters at 6-month follow-up will be invited for biochemical validation.

Eligibility Criteria:
Inclusion Criteria:

* Aged 25 or below
* Self-reported to smoke any types of tobacco products within the past 1 month
* Speak Cantonese and
* Provide verbal consent to counselling service.

Exclusion Criteria:

* have psychiatric disease
* and/or currently receive any smoking cessation intervention from other service providers
Effects of Vitamin D Supplementation on Strength, Bone Density, and Injury Risk in Collegiate Athletes

The goal of this study is to determine whether Vitamin D supplementation improves strength and bone density, and reduces the risk of injury in collegiate athletes.

Vitamin D is a hormone that is important for bone and muscle health. As such, not having enough vitamin D in your body is associated with increased risk of injury and reduced health and athletic performance. It is often recommended that individuals who have low levels of vitamin D take vitamin D supplements. However, the effects of vitamin D supplementation on health and strength gains in collegiate athletes are not known. The goal of this study is to determine whether vitamin D supplementation increases strength and bone density, while reducing the risk of injury in collegiate athletes. Fasting vitamin D concentrations will be measured and athletes will be supplemented daily with Vitamin D for 8-12 weeks. The amount of supplementation will depend on whether the athlete is categorized as sufficient (\>30ng/ml), insufficient (20-35ng/ml), or deficient (\<20ng/ml). Vitamin D concentrations, strength, bone density, and injury risk will be assessed before and after the intervention period.

Eligibility Criteria:
Inclusion Criteria:

* athlete for a sanctioned Virginia Tech sport

Exclusion Criteria:

* pregnant or trying to become pregnant, currently taking vitamin D (\>600IU/day), calcium (\>1000mg/dl), taking any performance enhancing supplements (example, creatine), or any other medication or nutritional supplements that might influence the study variables, cardiac or thyroid problems, have diabetes, or epilepsy
Antibiotic or Not in Non-purulent Exacerbations of COPD: a Trial of Security and Efficacy

COPD is one of the most important causes of morbidity and mortality and supposes a sanitary problem in Europe and USA. Patients with COPD usually have 1-2 episodes of acute exacerbation of COPD (AECOPD) per year, being these the principal causes of of hospitalizations, respiratory problems and medical visits. After an episode of AECOPD, the majority of patients develop a transitory (or permanent) worsening in their quality of life and 50% of them will require a new hospitalization. Globally, a 75%\& of the exacerbations might be associated with a respiratory tract infection, and among them, 50% might be related to bacteria and in 45% an evidence of viral infection could be documented. Even though the antibiotic treatment might not be useful for a majority of patients with AECOPD, is generalized its use(almost an 85% in some series) in hospitalized patients. The non-controlled use of antibiotics in AECOPD results in a very expensive disease and raises the rate of resistance of bacteria. The available literature have shown that there's a relation between exacerbations and infections, based on sputum samples.

In summary, is well known that at least a 50% of the episodes of AECOPD might be associated with pathogenic bacteria in the lower respiratory tract. Prescription of antibiotics is wide and generalized in hospitalized patients. Clinical trials have shown correlation between AECOPD with sputum purulence (which correlates with presence of bacteria), however they've not included NON-purulent AECOPD, even though they're a significative group of patients hospitalized by this cause too. It's necessary to evaluate the efficacy nor the security of antibiotic treatment in this group of patients in a well designed trial.


Eligibility Criteria:
Inclusion Criteria:

* COPD diagnosis according to GOLD guidelines
* Hospitalization for any acute exacerbation of chronic obstructive pulmonary disease
* Failure of outpatient treatment
* Increasing of dyspnea in the last days
* Comorbidity that causes detriment of respiratory function

Exclusion Criteria:

* Life expectancy of less than 6 months
* Mechanical Ventilation
* Cardiovascular condition that causes exacerbation
* Immunosuppression
* Pulmonary infiltrates that suggest pneumonia
* Antibiotic treatment in the last month
* Pregnancy
* ECG with a large QT segment
* Hypokalemia
* Hepatic failure or renal failure
Happy Homes, Healthy Families: A Relationship Strengthening Intervention for Pregnant Couples Affected by HIV in Zambia

The objective of this study is to test the preliminary efficacy of a novel couples' counseling intervention to promote the health of pregnant women living with HIV in Lusaka, Zambia.

The central hypothesis of this study is that women living with HIV in heterosexual couples that have better relationship functioning and more social support will have greater odds of achieving optimal health during and after pregnancy. The study further hypothesizes that the couples-based intervention will improve interpersonal dynamics, such as communication, and in intrapersonal factors, such as women's mental health, which will mediate intervention effects on HIV care and treatment outcomes. The study will test the hypotheses through two specific aims: (1) compare service utilization and prevention of mother-to-child transmission (PMTCT) outcome indicators in two study conditions; and (2) establish the effect of the intervention on intra- and inter-personal mechanisms influencing outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Heterosexual couple in a stable relationship (defined as sleeping under the same roof at least once a week)
* Relationship has lasted ≥ 6 months
* Both partners live in the clinic catchment area and plan to continue residing there for at least six months
* Both partners are at least 18 years of age
* Both partners willing to participate in the intervention
* Female partner is no more than 36 weeks pregnant
* Female partner is diagnosed as HIV-positive
* Severe intimate partner violence (World Health Organization definition) has not occurred within the couple in the past 6 months.

Exclusion Criteria:

* Same-sex couple
* couple who does not sleep under the same roof at least once a week
* Relationship has lasted \<6 months
* One or both partners live outside the clinic catchment area
* One or both partners plan to move outside the clinic catchment area
* One or both partners are \<18 years of age
* One or both partners unwilling to participate in the intervention
* Female partner is greater than 36 weeks pregnant
* Female partner is HIV-negative
* Severe intimate partner violence (World Health Organization definition) has occurred within the couple in the past 6 months.
Auricular Concha Electro-acupuncture for the Treatment of Depression

The objective of this study was to compare the therapeutic effects of Auricular Concha Electro-acupuncture and Citalopram on patients with major depressive disorder (MDD).

In this study, 106 patients with MDD were randomly divided into the auricular concha electro-acupuncture group and the citalopram group by the evaluation blind method and randomized control design, and were treated for 8 weeks and 4 weeks follow-up. In No. 0, 2, 4, 6, 8, 10, 12 Weekend, Hamilton Rating Scale for Depression-17 Item (HAM-D17) and Hamilton Anxiety Rating Scale (Ham-A) were performed for all patients. During the No. 0/8 weekend, patients were tested and analyzed for peripheral blood NE, 5-HT, DA, Cortisol, ACTH, GABA, glutamic acid, BDNF and BFGF, and the brain is also examined and analyzed by fMRI.

Eligibility Criteria:
Inclusion Criteria:

1. The diagnosis is consistent with DSM-V diagnostic criteria for mild-to- moderate depression;
2. Patients with the first onset or recurrence of the disease have not been treated with antidepressant or without antidepressant treatment before treatment for 3 months;
3. Age from 18 to 65 years old, with no gender;
4. Outpatient;
5. 17 Item Hamilton Depression Rating Scale (HAMD-17) score \> 7, and \<24;
6. Signed informed consent.

Exclusion Criteria:

1. In addition to depression, it conforms to the diagnostic criteria of any psychiatric disease;
2. Patients with a history of schizophrenia or other mental illness;
3. Patients with cognitive impairment or personality disorder;
4. In the past 6 months, patients who have met the DSM-V criteria for substance related and addictive disorders;
5. Before entering the group, any other antidepressant treatment is being accepted;
6. Patients with serious body disease, such as heart disease (namely Ⅱ and Ⅱ above cardiac function) , obvious abnormalities of liver and kidney function (Biomarkers more than 3 times normal);
7. Serious suicidal ideation or suicidal behavior.
MITIGAAT: Multifaceted Intervention to Improve Graft Outcome Disparities in African American Kidney Transplants

This is a randomized study to test a smartphone app that a pharmacist will use to help kidney transplant patients track their medications, blood pressures, and blood sugars in those with diabetes. The goal of this study is to improve care and outcomes in kidney transplant patients and, in particular, help African American patients have better outcomes after transplant.

The overarching hypothesis for MITIGAAT is that late non-adherence and suboptimal control of diabetes and hypertension are more common in African American kidney recipients and are major contributors to health disparities. A multimodal intervention that addresses these issues will significantly reduce disparities. This hypothesis will be tested through a rigorously conducted, prospective, 2-year randomized controlled trial in 190 kidney transplant recipients from MUSC, designed to assess the following aims:

Aim 1. Determine the impact of this multilevel health services intervention on achieving improved adherence to tacrolimus, measured using tacrolimus trough variability and time in range in the treatment vs control arm.

Aim 2. Determine the impact of this multilevel health services intervention on blood pressure (BP) and glucose control (in those with DM) in the treatment vs control arm.

Aim 3. Conduct a cost-benefit analysis (CBA), assessing the estimated hospitalization and ED visit costs in the intervention arm vs the control arm and compare this to the costs needed to deliver the intervention.

Aim 4. Compare the incidence of acute rejection, graft loss and death in the intervention patients vs. a large contemporary national cohort of Veteran kidney transplant recipients while also assessing racial disparities for these health outcomes

Eligibility Criteria:
Inclusion Criteria:

* ≥18 years of age
* ≥2 years post-kidney transplant

Exclusion Criteria:

* Non-kidney transplant recipient (liver, lung, heart, intestine, pancreas, bone marrow)
* Not capable of measuring own BP and glucose in those with diabetes
* Not capable of using mobile health application after adequate training
* Not capable of speaking, hearing, and reading English
A Comparison of Two Devices for Measuring the Central Thickness of the Cornea Before and After Surgery (CECOT)

Corneal topography allows the measure of the radii of curvature and of the thickness of the cornea. It is essential for diagnosis in ophthalmology and allows to highlight corneal irregularities such as a keratoconus, or too thin corneas which are a contra-indication for laser refractive surgery.

Several types of corneal topographers are commercially available. Some as the Orbscan(r), operate by analyzing the image of the patterns of a Placido disk associated with a light slit, allowing the collection of thousands of points of the anterior and posterior surface of the cornea. More recent systems such as the Pentacam(r) are based on automatic rotary cameras which capture images of the whole anterior segment of the eye. The aim of this study is to compare two topographs, the Pentacam(r) and the Orbscan(r) and, more specifically, the central corneal pachymetry measurements measured pre- and postoperatively.


Eligibility Criteria:
Inclusion Criteria:

* Patients for whom a LASIK refractive surgery is planned

Exclusion Criteria:

* hyperopic patient
* another refractive surgery technique
* pregnant or lactating woman
* patient's opposition to participation in the study, according to the law on research into routine care
* patient under a measure of legal protection
* absence of affiliation to social security
Clinical and Diagnostic Value of Ribosomal p2 Autoantibodies in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by production of autoantibodies directed against nuclear and cytoplasmic antigens. Clinically, this disorder is characterized by periods of remission and relapse (1). The early and accurate diagnosis of SLE is challenging (2).

The SLE pathogenesis involves multiple cellular components of the innate and immune systems, presence of autoantibodies and immune complexes, engagement of the complement system and cytokine dysregulation (3). About 180 autoantibodies have been identified in SLE patients, 102 of which are reported to have an organ-specific correlation with SLE disease identified in SLE patients, with SLE disease activity (4). However, with the exception of autoantibodies such as antinuclear antibody (ANA), anti double stranded DNA (dsDNA), anti-smith and antiphospholipid antibodies, currently proposed by the American college of rheumatology (ACR) (5)

systemic lupus international collaborating clinics (SLICC) (6) for the diagnosis of SLE, most of these autoantibodies lack sufficient sensitivity and/or specificity for use in clinical diagnosis. Discovery of additional autoantibodies with high sensitivity and specificity is important for early diagnosis and assessment of the prognosis of SLE (7).

Anti-ribosomal P(Anti-Rib-P) antibody, routinely tested in SLE, targets a homologous 22-amino acid C-terminal (C-22) sequence shared by three ribosomal phosphoproteins known as P0, P1, and P2 (8).

The prevalence of anti-Rib-P antibody is about 15-40% in SLE patients and varies with the ethnicity, disease activity and detection method (9). Studies have disclosed that anti-P antibodies react with activated T cells but not with B cells, suggesting possible direct effects of anti-P antibodies on immune regulation (10).

Eligibility Criteria:
Inclusion Criteria:

1. Patients who fulfilled the 2012 SLICC criteria (6).
2. SLE Patients \>= 18 years old.

Exclusion Criteria:

* 1-SLE Patients \< 18 years old. 2- Patients with other autoimmune diseases or malignancy.