cyrilzakka/clinical-trials huggingface dataset:
Effects of an Intervention Program by Proprioceptive Neuromuscular Facilitation, in Muscle Force Irradiation.

The present study aims to assess through surface electromyography, the effectiveness of proprioceptive neuromuscular facilitation protocols in the activation of the stabilizing muscles of the scapula and the anterior tibial muscle.

Healthy subjects and subjects with demyelinating polyneuropathy are involved in the study.

Healthy patients are arranged in two groups of stimulation: FNP Group (intervention proprioceptive neuromuscular facilitation) - CC Group (intervention classic cinesioterapia). The electromyographic response of the stabilizing muscles of the scapula of each individual will be assessed prior to application of the protocols, during the execution of the protocols and immediately after stopping in a single session.

Patients with demyelinating polyneuropathy are arranged in a single treatment group and will be treated at a frequency of twice a week for five weeks. In each session, the PNF patterns will be repeated four times, on both sides, stimulating muscle irradiation and evoking the contraction of the tibialis anterior muscle. During the repetition of the patterns, the dorsiflexor muscle response of each patient will be obtained by an electromyography (EMG) surface.

The data of the RMS values obtained in the first session will be normalized and transformed into percentage. The average RMS of each diagonal at the beginning of treatment corresponds to 100% of TA muscle activation. The RMS values obtained in the last session will be normalized as a percentage, taking into account the results of the first evaluation. After normalization, data from the first and last sessions will besubjected to the for paired t-test.

Eligibility Criteria:
Inclusion Criteria:

Healthy individuals group: who agree to participate in the study with no history of previous trauma or disease of the shoulder girdle, with absence of clinical signs painful in the shoulder joint.

Group with demyelinating polyneuropathy: both sexes, carriers of CMT-1A disease with functional changes in the lower limbs with good cognition and difficulty of to ambulate with and without assistance.

Exclusion Criteria:

Healthy individuals group: subject with restricted range of motion, muscle weakness, cognitive impairment, which exhibits a pathology that leads to alterations in muscle recruitment.

Patients with polyneuropathy: cardiac arrhythmias, uncontrolled hypertension, severe cardiovascular disease and respiratory problems. The use of own medicines to treat pathology was accepted.
Efficacy and Safety of Activated Recombinant Human Factor VII in Severely Injured Trauma Patients

This trial is conducted in Africa, Asia, Europe, Oceania and North America. The aim of this trial is to evaluate the efficacy of activated recombinant human factor VII given in conjunction with standard therapy in the treatment of massive bleeding in subjects with severe blunt and/or penetrating trauma injury.


Eligibility Criteria:
Inclusion Criteria:

* Informed consent obtained from the subject and/or his/her legally authorised representative (LAR) before any trial-related activities
* Injury(ies) due to a blunt and or penetrating trauma
* Receipt of 6 units of PRBC within a 4 hour period following admittance to the trauma centre
* Receipt of 8 units of PRBC upon administration of trial drug

Exclusion Criteria:

* Prehospital cardiac arrest
* Cardiac arrest in the ER or OR
* Gunshot wound to the head
* Glasgow Coma Scale below 8
* Base deficit of above 15 mEq/l or severe acidosis
* Transfusion of 8 units or more of PRBC prior to arrival in trauma centre
Examining Clinical Trial Participation for Small Cell Lung Cancer Patients

Clinical study participation percentages haven't always been fully representative of a given demographic.

The goal is to find out which aspects of a clinical trial may make it more difficult for patients to take part or see it through.

The data will be evaluated through different demographic lenses and identify trends that could help improve the experience of future small cell lung cancer patients during clinical trials.


Eligibility Criteria:
Inclusion Criteria:

* Aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed.
* Participant has a diagnosis of small cell lung cancer.
* Willing and able to comply with scheduled visits, treatment schedule, laboratory tests and other requirements of the study.

Exclusion Criteria:

* Patients with any significant history of non-compliance to medical regimens or with inability to grant a reliable informed consent.
* Pregnant or lactating woman
* Known medical condition that, in the investigator's opinion, would increase the risk associated with study participation or study drug(s) administration or interfere with the interpretation of safety results
Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer

This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.


Eligibility Criteria:
Inclusion Criteria:

* Individuals who have undergone clinical and/or research genetic evaluation, found to have or not have a germline genetic variant (pathogenic, likely pathogenic, variant of uncertain/unknown significance, likely benign).
* Individuals with or without a personal history of malignant or pre-malignant lesions who demonstrate: a) clinical findings suggestive of a genetic cancer susceptibility syndrome including very early age at onset, multiple primary malignancies, or other features; and/or b) family histories suggestive of a genetic cancer susceptibility syndrome, or c) other features suggesting inherited etiology of malignancy as determined by the PI.
* Family members of the above participants. Both children (with parental consent as age appropriate) and adults are eligible to participation.
* Individuals may or may not be enrolled MSK patients; probands may be referred to (or self-referred to) the study and may be enrolled at discretion of the PI and if able to provide informed consent.
* Biospecimens derived from deceased family members may be used for research in this study if consent if provided by the executor of the estate of that individual.

Exclusion Criteria:

* Patients will be excluded from this study if he/she has physical, cognitive or psychiatric conditions that interfere with ability to give meaningful informed consent.
Validity and Reliability of the Six-minute Peg Board and Ring Test in Chronic Neck Pain

The purpose of this study was to evaluate the validity and reliability of six-minute peg board and ring test (6-PBRT) in individuals with chronic neck pain and to determine the applicability of the test for this patient population.

Neck pain is the fourth leading cause of disability worldwide and is a significant public health problem. Chronic neck pain is defined as the presence of pain in the neck region of individuals for more than twelve weeks. Chronic neck pain is a disorder that negatively affects the individual's daily life activities and causes labor force and economic losses by causing functional limitations, loss of work and disability. It is important to evaluate the physical fitness components in detail in individuals with chronic neck pain. It has been stated that neck pain reduces upper extremity performance.

Different measurement methods have been used to evaluate the upper extremity functions of individuals. Standard measurement tools are needed to evaluate the upper extremity exercise capacity in patients with chronic neck pain. The 6-PBRT is a valid, reliable, useful, practical and easy-to-apply test that evaluates the endurance of the upper extremity without support in healthy individuals and those with chronic obstructive pulmonary disease. The validity and reliability of 6-PBRT, which is used to evaluate functional upper extremity exercise capacity in different diseases, has not been investigated in individuals with chronic neck pain. The aim of this study was to evaluate the validity and reliability of 6-PBRT in individuals with chronic neck pain and to determine the applicability of the test for this patient population.

Eligibility Criteria:
Inclusion Criteria:

* Individuals with neck pain that has lasted at least 3 months due to problems such as cervical strain or sprain, cervical disc lesions, cervical spondylosis, facet joint dysfunction and myofascial pain syndrome,
* Those between the ages of 18-65,
* Individuals who volunteer to participate in the study will be included in the study.

Exclusion Criteria:

* Neck pain severity under 3 point during activity according to Visual Analog Scale
* Motor deficit in upper extremity neurological examination
* Undergone any surgery related to neck problem
* Presence of cervical radiculopathy
* Undergone any upper extremity surgery,
* Presence of rheumatic and/or neurological disease or any disease affecting the vestibular system
* Presence of carpal tunnel syndrome, rotator cuff syndrome, impingement syndrome, thoracic outlet syndrome, lateral and medial epicondylitis, hand osteoarthritis that will affect upper extremity and hand functions
* Individuals with cognitive dysfunction who will understand and apply the exercise test instructions will be excluded from the study.
Effectiveness of Hexaminolevulinate (Hexvix) in the Diagnosis and Treatment of Patients With Non-invasive Bladder Cancer

The purpose of this study is to determine the effectiveness of hexaminolevulinate (Hexvix) in the diagnosis and treatment of patients with non-invasive bladder cancer and if it results in a change in patient management.


Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years of age.
* Patients of either sex.
* Patients with documented or highly suspected non-invasive bladder cancer.

Exclusion Criteria:

* Patients with hypersensitivity to the drug substance or any excipient of Hexvix.
* Patients with porphyry.
* Women of childbearing age.
* Patients at a high risk of suffering extensive bladder inflammation e.g. patients after intravesical BCG treatment, patients with moderate or severe leukocyturia or patients undergoing recent bladder surgery.
Efficacies of Different Managements in Patients With Trigger Finger

The aim of the study is to compare the effectiveness of peritendinous steroid injection under ultrasound guidance and percutaneous A1 pulley release procedures in terms of disease stage, pain, and severity of locking in patients with trigger finger.

This study was designed as a randomized, controlled, prospective study. Patients who had been experiencing trigger finger symptoms for at least one month and who presented to the Gaziler Physical Medicine and Rehabilitation Training and Research Hospital, affiliated with the Health Sciences University Faculty of Medicine

Patients were randomly divided into two groups: the peritendinous steroid group (n=15) and the percutaneous pulley release group (n=15). In the first group, under ultrasound guidance, a mixture of 1 ml corticosteroid (2 mg+5 mg/ml betamethasone) and 1 ml local anesthetic (20 ml 2% prilocaine) was injected peritendinously between the A1 pulley and the flexor tendon sheath. In the second group, a percutaneous A1 pulley release procedure was performed under ultrasound guidance using a 20 G needle, followed by peritendinous injection of the same mixture of corticosteroid and local anesthetic.

Patients were evaluated four times: before treatment, at 1 week, 1 month, and 3 months after treatment. Modified Quinnel classification, VAS (Visual Analog Scale), and severity of locking scales were used as outcome measures in the study.

Eligibility Criteria:
Inclusion Criteria:

* Being over 18 years of age
* Having had trigger finger complaints for more than 1 month
* Not having received any injections for trigger finger diagnosis within the last 1 month
* Signing the informed consent form indicating willingness to participate in the study

Exclusion Criteria:

* Refusing to participate in the study
* Presence of partial or complete tendon rupture in the relevant tendon of the finger to be treated
* Presence of wounds and infection in the area where the procedure will be performed
* Pregnancy status
* History of allergy to the injected medications (local anesthetic, steroid)
Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses: an Experimental Study in Iron-deficient Women

Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin following the administration of a daily iron dose for two months.


Eligibility Criteria:
Inclusion Criteria:

* Low iron stores (SF levels \< 30 µg/L),
* no anemia (Hb \> 120 g/L)
* no inflammation (CRP \< 5 mg/L)
* 18 to 45 years old.
* Body weight \<70 kg
* Normal body Mass Index (18.5-26.5 kg/m2)

Exclusion Criteria:

* Any chronic or acute disease
* Consumption of mineral and vitamin supplements since screening and over the study period
* Blood transfusion, blood donation or significant blood loss over the past 4 months,
* Pregnant or breastfeeding,
* Continuous/long-term use of medication during the whole studies (except for contraceptives)
* Therapeutic iron infusion over the past 6 months,
* Known hypersensitivity or allergy to iron supplements,
* Intention to become pregnant over the course of the study
Mobile Application for Integrative Diabetes Care

The investigators have developed a mobile application named 'DangDang Care' (which conveys the meaning of managing diabetes confidently and consistently through psychological care) designed to provide psychological support and enhance diabetes self-management for people with type 2 diabetes experiencing depressive symptoms. The application incorporates a behavioral activation program. Subsequently, the investigators conducted a 12-week randomized controlled trial, enrolling individuals with type 2 diabetes and mild-to-moderate depression, with the assistance of public health centers. The trial aimed to assess the effectiveness and feasibility of the application in promoting consistent diabetes management through added psychological care.


Eligibility Criteria:
Inclusion Criteria:

* Adults aged 20 to 80 years with type 2 diabetes
* Individuals belonging to disadvantaged populations, such as medical aid beneficiaries or those classified as low-income groups
* Mild-to-moderate depressive symptoms, defined as a Patient Health Questionnaire-9 (PHQ-9) score between 5 and 19
* Capable of reading and understanding Korean and using a mobile application
* Having a clear understanding of the study's purpose and providing written consent

Exclusion Criteria:

* Type 1 diabetes or gestational diabetes
* Diabetes complications that hindered diabetes self-management
* Severe depressive symptoms that made app usage and completion of the self-report questionnaire difficult
* Serious mental illnesses other than depressive symptoms (e.g., schizophrenia and related disorders, bipolar and related disorders, or neurodegenerative disorders)
* Serious life-threatening medical conditions
* Physical conditions that impeded mobility
* A history of traumatic brain injury
* Unwillingness to complete the questionnaire and provide personal information
Whole-body Vibration Without Visual Feedback on Postural Steadiness in Unilateral Trans-femoral Traumatic Amputees

This study will investigate the effects of Whole-body vibration without visual feedback on postural steadiness in unilateral trans-femoral traumatic amputees. This study will be carried out at the outpatient clinic of the faculty of physical therapy, modern university for technology and information, and El Wafaa wel Amal hospital.

All participants will sign a written consent form after receiving full information about the purpose of the study, procedure, possible benefits, privacy, and use of data.

The postural steadiness is the dynamics of the postural control system associated with maintaining balance during quiet standing and usually assessed by the displacement of the centre of pressure (COP).

The control of posture is maintained by a complex sensory-motor system, which integrates information from the visual, proprioceptive, vestibular and somato-sensory systems. In the case of a unilateral trans femoral amputee, the individual becomes structurally asymmetrical, as there is an altered sensation and a loss of musculature on the amputated side. Whole-body vibration (WBV) is a therapeutic method that exposes the entire body to mechanical oscillations while the patient stands or sits on a vibrating platform. This method was used in rehabilitation to improve muscle function, joint stability, balance control and to reduce the risk of falling.

Whole-body vibration (WBV) training helps to improve the dysfunction of the nervous system and musculoskeletal system diseases, to prevent and relieve osteoporosis in the elderly, and to promote sports injury recovery and improve sports performance. But till now there is no judgment concerning the difference and significance of Whole-body vibration without visual feedback on postural steadiness in unilateral trans-femoral traumatic amputees.

Eligibility Criteria:
Inclusion Criteria:

* 40 to 55 years of age.
* Residual femoral length from ischial tuberosity to the end of the limb with distal soft tissue compressed (15-35 cm)
* Unilateral trans-femoral traumatic amputation with single-axis mechanical knees, axial foot (single axis).
* Able to walk without the use of any assistive device; subjects must have obtained a score of \> 5 for Houghton Scale to indicate active use of prosthesis and \> 41 for Berg Balance Scale (BBS).
* Medicare level 3 (community) ambulatory or above.
* Ability to descend stairs and hills without caregiver and assistive devices.
* Be able to independently provide informed consent.
* Be willing to comply with study procedures.

Exclusion Criteria:

* Reduced somatosensory sensibility of the non-affected limb, ulceration or pain at the stump
* the amputation was of vascular origin
* Poor fittings of prosthesis
* Visual or vestibular impairment (vertigo or dizziness)
* Lower limb musculoskeletal injury and other neurological deficits
Impact of the Social Determinants of Health in the Central Catalan Region

The objective of this study is to increase the registry of social determinants of health in the primary care centers and evaluate the relationship that these social determinants of health with various variables of social impact.

Currently, the social problems are hidden behind clinical diagnostics. This may lead to overdiagnosis and overtreatment of some discomforts/pathologies that are observed in primary care centers that may respond better to community level interventions and promotion of health actions.

It is longitudinal , multicentered, pre and post intervention study, conducted by health professionals of central Catalonia sanitary region during 2019 Prior to the intervention, the number and type of social coded diagnoses in the clinical history is going to be described. Subsequently, an intervention will be carried out: training the professionals in the homogeneous codification of five selected social determinants. This codification will be systematically applied .The number and type of social diagnostics registered in the pre and post-intervention periods is going to be compared. Finally, the impact analysis of the social determinants is going to be carried out.

Afterwards the investigators plan to search solutions at Community level for the select social diagnoses

Eligibility Criteria:
Inclusion Criteria:

Phase I:

* Patients have been attended in their primary care centers during 23 September 2019 to 23 April 2020.
* The health professionals should complete the study checklist for each patient .

Phase II:

•Patients should sign the informed consent form to enter in a study cohort.

Exclusion Criteria:

Patients with advanced cognitive impairment because they would not be able to complete the study checklist. The study checklist is consist in answering five questions.
Mindfulness-based Intervention to Promote Psychological Wellbeing in People With Epilepsy

The efficacy of mindfulness-based intervention (MBI) for epilepsy has yet to be thoroughly investigated. Hence, the aim of the present study is to examine the effects of MBI on the psychological wellbeing of people with epilepsy (PWE) using a randomized trial design. Key outcomes include depression, anxiety and quality of life. Our primary objective was to evaluate the effect of mindfulness-based therapy on anxiety, depression, epilepsy specific QOL, and life satisfaction in PWE, applying the concept of Reliable Change Index. The secondary objective was to assess whether the results correlate with the level of mindfulness. Study results may be used to decide whether it is worth offering mindfulness training for PWE as an alternative therapy to cope and improve seizure management.

Epilepsy is a debilitating condition characterized by sudden recurrent episodes of epileptic seizures. Psychiatric comorbidities are common in people with epilepsy (PWE), and the presence is associated with increased rates of suicide, healthcare costs, mortality and reduced quality of life. Studies showed that poor health-related quality of life (HRQOL) has been linked to seizure frequency, medication side effects, psychological disturbances and psychosocial difficulties. Medical therapies aside, psychological interventions like mindfulness-based interventions (MBIs) were proven effective in improving psychological health as well as seizure control. Recent review was conducted to determine the efficacy of MBIs for PWE. Although promising results showed reduction in levels of psychological distress and improvement in quality of life, the extracted findings were based on three articles which limit the applicability of the findings. More research focusing on MBIs for PWE are required to make comparisons on its beneficial effects. Hence, this present study aimed to examine the effects of MBI on psychological wellbeing among PWE using a randomized controlled trial design.

This study trial recruits 30 participants with epilepsy. Participants are recruited from the neurology outpatient treatment clinic and those who consented are randomized into either the intervention active or no-intervention group. All participants receive six weekly-sessions of mindfulness training that lasted for 2.5-hour. Assessments are conducted at three time-points (T0: before intervention, T1: immediately after intervention, and T2: at the 6-weeks followup). The following outcome measures assessing depression (BDI-II), anxiety (BAI), quality of life (QOLIE-31), mindfulness (MAAS) and satisfaction with life (SWLS) are collected at all three time-points.

Eligibility Criteria:
Inclusion Criteria:

* All patients (16 years or older) with a diagnosis of epilepsy by a neurologist and who were able to read and write English.

Exclusion Criteria:

* a diagnosis of severe learning disability or cognitive impairment that affects individuals who are unable to comply with study procedure, substance dependence, suicidality, and limited language proficiency.