cyrilzakka/clinical-trials huggingface dataset:
Determinants of Balance in Patients With Chronic Obstructive Pulmonary Disease

The primary aim of our study is to examine the relationship between balance and respiratory function, respiratory and peripheral muscle strength, functional capacity, and cognitive function in patients with Chronic Obstructive Pulmonary Disease (COPD). The secondary aim of our study is to compare respiratory function, respiratory and peripheral muscle strength, functional capacity, balance, and cognitive functions of COPD patients and healthy individuals. This study will examine and record the participant's sociodemographic information and medical records. Balance, respiratory function, respiratory and peripheral muscle strength, functional capacity, and cognitive function will be assessed. Since the patients are included in this study, no intervention will be made, no additional tests will be performed, or no changes will be made in the routine treatments of the patients during the study.


Eligibility Criteria:
COPD Group Inclusion Criteria:

* Being diagnosed with COPD in accordance with the GOLD criteria
* Being between the ages of 40-65
* To be able to speak, read, understand, and cooperate in Turkish
* Being a volunteer to participate in the study

COPD Group Exclusion Criteria:

* Having a COPD exacerbation in the last 8 weeks and/or having an unstable clinical condition
* Having a diagnosed vision, hearing, or neurological disease that may affect balance
* Having any other neurological, orthopedic, cardiovascular, thoracic, or metabolic disease or pathological condition that would affect assessments
* Resting saturation below 90% during exercise tests
* Being on long-term oxygen therapy

Control Group Inclusion Criteria:

* Being between the ages of 40-65
* To be able to speak, read, understand, and cooperate in Turkish
* Being a volunteer to participate in the study

Control Group Exclusion Criteria:

* Having a diagnosed vision, hearing, or neurological disease that may affect balance
* Having any other neurological, orthopedic, cardiovascular, thoracic, or metabolic disease or pathological condition that would affect assessments
* Resting saturation below 90% during exercise tests
Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI

The study is designed to determine whether hemorrhage within the injured spinal cord is influenced by mean arterial pressure (MAP) augmentation with vasopressors and by venous thromboembolism (VTE) prophylaxis with anticoagulants in the first two weeks following a traumatic spinal cord injury (tSCI).

This will be a single-center prospective observational study of patients with an acute cervical traumatic spinal cord injury

Eligibility Criteria:
Inclusion Criteria:

* Acute tSCI injury involving bony spinal levels between C0 and T1
* Baseline Asia Impairment Scale (AIS) grade of A, B, or C
* Admission to study site within 24 hours of injury
* Male or female age 19 or older
* Able and willing to provide informed consent

Exclusion Criteria:

* Pathological fracture due to metabolic condition or neoplasia
* Spinal cord injury due to infection
* Presence of pacemaker, aneurysm clip or other device which is a contraindication to MRI
* BMI \> 40 and unable to fit within the MRI scanner
* Multiple life threatening injuries (ISS \>16) that make transport to MRI not in the patient's best interest
* Any condition that, at the time of admission, prevents a complete ISNCSCI assessment from being performed
Nasopharyngeal Versus Nasal Cannula Oxygen Supplementation in Surgery Patients

The investigators plan to conduct a randomized, controlled trial comparing nasopharyngeal oxygen supplementation to traditional nasal cannula in patients undergoing oral surgery under moderate sedation.


Eligibility Criteria:
Inclusion Criteria:

* Patients greater than 16 years of age
* Patients who present for oral surgery or esophagoduodenography and colonoscopy
* Patients who undergo intravenous sedation

Exclusion Criteria:

* Patients who require endotracheal intubation
* ASA class 4 or higher
* Existing esophageal disease such as a perforation or varices
Earlier Mobilization Post Acute Thrombolysis

This is a phase III trial trying to determine whether 12-hour bed rest following IV thrombolysis therapy (i.e. tPA) for ischemic stroke is non-inferior to 24-hour bed rest by measure of outcomes on the modified Rankin Scale (mRS) at 90 days post bed rest.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 years or older
* Received intravenous tPA for a clinical diagnosis of acute ischemic stroke
* Patient and/or Legally Authorized Representative provide consent

Exclusion Criteria:

* Venous thromboembolism present at symptom onset
* Pneumonia present at symptom onset
* STEMI at symptom onset
* Positive troponins at symptom onset according to local values
* Bone fracture at symptom onset
* Treatment includes or anticipated to include thrombectomy
* Intubation anticipated or occurred
* Symptomatic intracranial hemorrhage (defined as increase in NIHSS by 4 points or more accompanied by PH2 hemorrhage on imaging) at the time of screening.
* Pre-screening systolic blood pressure \< 110 mmHg
* Resting pulse oximetry \< 92% (with or without supplemental oxygen)
* Neurological worsening (defined as NIHSS increase of 4 points compared to initial score) prior to screening.
* Baseline modified Rankin Scale score \> 2
* Known pregnancy
* Patient not anticipated to survive 3 months
* Patient not anticipated to follow-up at 3 months
ILSI Energy Balance Study

The purpose of this study is to apply measurement error techniques on consumer devices to assess rate of energy storage \[ES\] and energy expenditure \[EE\], then estimate EI using the intake-balance technique.

The goal of this study is to develop calibration models that will be able to be translated to other consumer devices with only minor modifications given common hardware (e.g. triaxial accelerometry), resulting in overall improved ability to assess energy balance and EI at a population level and positive health outcomes.

There are four stages in the proposed project: 1) We will validate EE and ES (hereafter, Fitbit_EE and Fitbit_ES) from a consumer physical activity monitor (Fitbit Alta HR™) and body composition analyzer (Fitbit Aria™) with gold-standard measures of DLW for EE and DXA for ES during a 14-day baseline period; 2) We will estimate EI using the intake-balance method during the 14-day baseline period; 3) We will calibrate daily Fitbit_EE and Fitbit_ES from consumer devices using a Bayesian semi-parametric measurement error modeling approach to estimate energy balance; 4) We will reassess our validation and calibration models of consumer devices during a 14-day post-study assessment period to evaluate changes associated with growth and development with gold-standard measures of DLW for EE and DXA for ES.

Aims of the proposed study are to:

Specific Aim 1. Validate and calibrate consumer devices to estimate energy balance using gold-standard methods and a Bayesian semi-parametric approach. Hypothesis 1: We will be able to jointly model measurement error for both EE and ES to create a calibration model that reduces bias and improves accuracy of consumer devices of EE and ES.

Specific Aim 2. Estimate energy intake using the intake-balance technique using consumer monitors. Hypothesis 2:We will use calibrated EE and ES from consumer monitors to estimate EI using the intake-balance technique, with values being superior to self-reported EI.

Eligibility Criteria:
Inclusion Criteria:

* Healthy children and adults, aged 8-90.
* Able to be physically active.

Exclusion Criteria:

* History of restrained eating, eating disorders, bariatric surgery, or other significant medical diagnosis that could impact metabolism.
* Participants taking thyroid medications, beta blockers, or other stimulants (medications are known to affect metabolism).
Evaluation of the Effectiveness of Obstetric Lubricant Gel in Labor in Nulliparous and Primiparous Women: A Randomized Controlled Study

The investigators hypothesized that the application of lubricant gels at the beginning of the active phase of the labor may reduce duration of the delivery and episiotomy rates. The aim of this study is to investigate and confirm this hypothesis through a randomised controlled trial.

All participants in the study received standard routine antepartum care in the delivery room. Obstetric lubricant gel was applied to patients in the study groups, which had 47 nulliparous and 50 primiparous patients. Perinatal outcomes were compared between the groups.

The participants were divided into two groups based on their parity: nulliparous and primiparous. Initially, each group had 110 participants. Nulliparous and primiparous groups were randomly assigned to two groups as study and control groups using a computer-generated random number table. In this randomized controlled trial, participant allocation was carried out using a computer program to ensure a randomized and unbiased selection process. The randomization procedure was conducted in a double-blind manner, with the study investigators remaining unaware of the allocation until the conclusion of the study. All participants in the study received standard routine antepartum care in the delivery room. Among all patients, 25 participants were lost to follow-up during the study. Consequently, obstetric lubricant gel was applied to patients in the study groups, which included 47 nulliparous and 50 primiparous patients. Perinatal outcomes were compared between the groups

Eligibility Criteria:
Inclusion Criteria:

* Nulliparous and primiparous singleton pregnancies between 37 and 41 weeks + six days of gestation and vertex presentation of fetus with an estimated birth weight of 2000 - 4500g were included in the study

Exclusion Criteria:

* Multiparous pregnancies and women who had ceserean section before and/or contraindication for vaginal delivery were excluded from the study.
Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation

This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.


Eligibility Criteria:
Inclusion Criteria:

1. Patients aged between 25 to 35 years old.
2. Patients scored as (ASA I).
3. No adverse habits such as smoking, tobacco chewing, alcohol.
4. Patients having bilaterally impacted mandibular third molar with similar degree of difficulty according to (Kim JY, et al).
5. The recipient alveolar sockets are free of any pre-existing periapical pathology, based on x-ray.
6. Alveolar sockets with a depth of 5 mm or more, using periodontal probe for assessment.
7. Patients sign a consent for all procedures.

Exclusion Criteria:

* 1) Pregnant or lactating patients. 2) Relevant systemic diseases. 3) Patients with history of chemotherapy or radiotherapy.
Reoxygenation for Cyanotic Pediatric CHD

Evidence is emerging that those patients with cyanotic pathologies may be more vulnerable to end-organ injury during and after surgery than those patients without, because of compromised cardiopulmonary performances or the proinflammatory state that follows conventional hyperoxic cardiopulmonary bypass.

Several clinical and basic studies have identified that controlled oxygenation during the initiation of bypass significantly improved the cardiac adaptation and remodeling capacity than hyperoxic oxygenation strategy among cyanotic patients undergoing tetralogy of Fallot repair, as evidenced by these reduced myocardial gene expression profiles associated with reoxygenation injury.

The investigators designed the reoxygenation for pediatric cardiac surgery study to investigate the effect of reoxygenation during cardiopulmonary bypass on clinical outcomes in patients with cyanotic congenital heart disease .


Eligibility Criteria:
Inclusion Criteria:

* The operation-naive infants and young children aged 1 months to 18 years old were eligible for enrolment if they were indicated for undergoing anticipated radical repair of cyanotic congenital heart disease with cardiopulmonary bypass.

Exclusion Criteria:

* The chromosomal defects, airway and parenchymal lung disease, immunodeficiency, blood transfusion during the current admission, previous cardiac operation, or the opinion of the treating physician that randomization would not be in the best interest of the patient (lack of equipoise)
Motivational Interviewing With Dyslipidemic Adolescents Together With a Parent Versus With Adolescents Alone: A Mixed Methods Clinical Trial

The primary focus of this proposal is to address growing concern of overweight/ obese adolescents with hyperlipidemia. The proposed study is a 2-arm randomized controlled clinical trial to compare the effectiveness of Motivational interviewing (MI) interventions with the parent and adolescent dyad versus adolescent (10-17yr) alone. The patients will be recruited from the Lipid clinic at Sick Kids. The study hypothesis is that parent child dyad will have more success due to the possible synergetic effect compared to adolescents alone. The study's primary outcome is cholesterol levels (Triglycerides/HDL ratio) and secondary outcomes include overall improvement in their lifestyle and their responses to the MI intervention.


Eligibility Criteria:
Inclusion Criteria:

* Age at randomization: 10-17 years old
* 12 hour fasting lipid profile with triglycerides ≥39 mg/dL (1.0 mmol/L) or HDL-C ≤46 mg/dL (1.2 mmol/L), and with non-HDL-C ≥123 mg/dL (3.2 mmol/L)
* Waist to height ratio ≥0.5.

Exclusion Criteria:

* On lipid lowering medication
* non-English speaking
* Developmentally delayed
baSal BoluS Therapy in patIenTs With TypE 1 Diabetes Mellitus

Primary Objective:

To evaluate the efficacy of the association Lantus (once-a-day, od) Apidra (thrice-a-day, tid) in terms of change HbA1c from baseline to end of study (week 24), in patients with Type 1 Diabetes Mellitus (T1DM).

Secondary Objectives:

To evaluate:

* The change of hemoglobin A1c (HbA1c) from baseline to week 12
* The percentage of patients with HbA1c \< 7% at week 12 and week 24
* The FBG and the 7-point self monitoring of blood glucose (SMBG) at baseline, week 12 and week 24
* The daily dose for both insulin glulisine insulin glargine at baseline, week 12 and week 24
* The incidence of symptomatic hypoglycemias
* Adverse events

After a two-week run-in period patients will enter a six-month treatment period.

Estimated study duration per patient : 26 weeks (including a 2-week run-in period).

Eligibility Criteria:
Inclusion criteria:

1. Known Type 1 diabetic patients (male or female) treated with any type of insulin regimen, except:

   * continuous subcutaneous insulin infusion (CSII, or pump), and
   * patients already treated with insulin glargine
2. Age: 18-60 years inclusive
3. HbA1c: 8% - 10% assessed over the past 6 month
4. At least 1 year of continuous insulin treatment
5. Willingness to accept, and ability to follow:

   * a basal bolus regimen (glargine x1 and glulisine x3 per day),
   * self-monitoring blood glucose (SMBG)
   * a fixed meal plan, or CHO counting
6. Signed informed consent obtained prior to any study procedure

Criteria for entry in the treatment period:

1. HbA1c 8-10% assessed between week -2 and week 0
2. Serum creatinine ≤135 micromol/L in men and ≤110 micromol/L in women
3. Alanine aminotransferase (ALT) and/or Aspartate aminotransferase (AST) lower or equal to three times the upper limit of normal
4. Pregnancy test negative if women of childbearing potential

Exclusion criteria:

1. History of hypersensitivity to insulin glargine and/or insulin glulisine
2. Pregnant, breast-feeding or women of childbearing potential not using efficient contraception
3. Brittle diabetes
4. Known impaired renal function defined as serum creatinine \> 135 micromol/L in men and \> 110 micromol/L in women at study entry
5. Known impaired hepatic function defined as Alanine aminotransferase (ALT) and/or Aspartate aminotransferase (AST) greater than three times the upper limit of normal at study entry
6. Diabetes ketoacidosis
7. History of drug or alcohol abuse
8. Psychiatric or mental disease
9. Inclusion in another study in the past 6 months or previous inclusion in this study
10. Patient unable or unwilling to manage properly the basal bolus regimen

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Sprint Snacks: The Effects of Prolonged Rest on Reduced Exertion Interval Training.

An adapted sprint interval training protocol involving 2-3 repeated 20-second sprints separated by 2-3 minutes rest (termed reduced exertion high- intensity interval training (REHIIT)) has been developed and has been shown to promote fitness benefits. This data shows how little exercise one may need to improve cardiorespiratory fitness, provided they are willing to work very hard. However, it is unknown whether the benefits of REHIIT are because of the "all-out" nature of the sprint efforts themselves or the pattern of completing sprints with relatively short (i.e., minutes) rest periods within a workout session.

We are inquiring whether performing the same number and style of sprints with prolonged rest (i.e., 1-4 hours of rest in between sprints) is equally effective for improving aerobic fitness when compared to more traditional sprint interval training with 2-3 minutes of rest between sprints. Such information may make the effectiveness of sprint training more accessible and approachable for individuals unwilling or unable to plan a purposeful REHIIT exercise session into their day. If the rest interval could be prolonged then it may be possible to perform a few sprints as "exercise snacks" throughout the day without the need for a structured interval training session.


Eligibility Criteria:
Inclusion Criteria:

* Physically inactive (2 or less bouts of purposeful exercise per week)

Exclusion Criteria:

* If your doctor has informed you that you have a heart condition and should only do physical activity recommended by a doctor.
* If you feel pain in your chest when you perform any physical activity.
* If in the past the month you have had chest pain when you were not doing any physical activity.
* If you lose your balance or consciousness because of dizziness.
* If you have bone or joint problem (for example, back, knee, or hip) that could be made worse by a change in your physical activity.
* If you are currently pregnant or planning on becoming pregnant in the next 6 weeks.
* You have previously had a heart attack or stroke
* You are currently engaging in high-intensity interval training.
* You are currently physically active (engaging in 3 or more bouts of purposeful exercise per week; a "bout" is defined as structured, planned exercise lasting at least 30 minutes)
* You have severe chest pain or blood pressure over 240/140 during baseline testing.
* You have exercise induced asthma or a history of syncope.
Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation

The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical ventilation for acute respiratory failure.

The main question\[s\] it aims to answer are:

* to evaluate which weaning trial is associated to a better regional ventilation distribution
* to evaluate which weaning trial can be comparable to ventilation distribution after extubation

Participants will undergo 3 clinically used weaning trials in a random order (cross-over trial). Researchers will compare the different steps to see if regional ventilation distribution is different among the different trial .


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 and \< 70 years
* Ready to be weaned from mechanical ventilation according to clinical criteria

Exclusion Criteria:

* Age \< 18 years or \> 70 years
* Presence of chest drains
* Presence of pacemaker/impantable cardiac device;
* diagnosis of Pneumothorax, or pneumomediastinum
* Diagnois of neuromuscular diseases
* Use of neuromuscular blockers in the 48 hours before screening;
* Body mass index \> 35 kg/m2
* Refusal to participate of the patient/next of kin
A Study of Paramedic HF Management

The purpose of this research is to see if having community paramedic (CP) visit patients at home to manage their heart failure help them stay out of the hospital and improve their overall health compared to standard care. The investigators want to find out if their approach is better for patients in terms of their quality of life, hospital stays, emergency visits, and cost. The investigators are also looking to see how happy patients and doctors are with this method and if it's a practical and sustainable option for the future.


Eligibility Criteria:
Inclusion Criteria:

One of the following criteria:

1. Adults admitted to the hospital with decompensated HF eligible for early discharge with CP support and monitoring.
2. Acutely decompensated HF patients at home or being evaluated in the ambulatory clinic who require large volume diuresis but do not require hospital-level monitoring.
3. Stage D advanced HF patients who require frequent (\>weekly) diuretic adjustments (either inpatient or outpatients).

Exclusion Criteria:

1. Hospital-level monitoring or care is clinically indicated.
2. Failed safety assessment, active substance abuse, or behavioral health diagnosis which could impact participation.
3. Enrolled in hospice.
4. Patient is a resident in a skilled nursing facility.
5. Patient does not have a primary care physician or cardiologist at Mayo Clinic.
6. Patient participants with communication barriers due to medical illness or cognitive impairment.
7. Pregnant
A Real-world Study of Octreotide Microspheres in Chinese Patients With Neuroendocrine Tumors

The aim of this multicenter, open-label, observational study is to evaluate the safety and efficacy of octreotide microspheres in the treatment of advanced neuroendocrine tumors in real clinical practice, especially to evaluate the treatment of octreotide microspheres in various subgroups of neuroendocrine tumor patients.


Eligibility Criteria:
Inclusion Criteria:

1. Sign an informed consent form and voluntarily participate in this study;
2. Patients with unresectable or metastatic neuroendocrine tumors confirmed by histopathology. Patients with recurrence and progression after surgery or local treatment can also be included in the study;
3. Age ≥ 18 years old;
4. Treatment with octreotide microspheres.

Exclusion Criteria:

1. Confirmed pregnant or lactating women;
2. Participating in any research with intervention measures outside of routine clinical practice;
3. Other situations unsuitable for inclusion in the study determined by the researcher.