cyrilzakka/clinical-trials huggingface dataset:
Effect of Referent Type on Balance in Action Observation.

The objective of the study is to analyze whether observing the actions of a referent selected by the participants improves balance in asymptomatic individuals compared to those who observe a standard referent.

Design: Randomized controlled clinical trial. The primary endpoint of the study was the balance recorded by force platform (estatic) and Y balance test (dynamic).

Setting: The participants will be healthy people in the province of Tarragona.

Participants: They will be randomly assigned to one of three groups using a computerized randomized list:

* Control Group (CG): Participants will watch a video of landscapes without human or animal movement.
* Intervention Group with Referent (GIR): Participants will observe actions whose referent has been selected by themselves based on perceived similarity.
* Standard Intervention Group (GIE): Participants will observe actions with a standard reference.

Eligibility Criteria:
Inclusion Criteria:

* Be of legal age.
* Have a mobile device.
* Have normal or corrected-to-normal vision.
* Absence of neurological, orthopedic or vestibular disorders.
* Absence of specific balance skills due to competitive sports.
* Obtain a score of 3 or less on the Tegner activity scale.
* Having voluntarily signed the informed consent and being willing to follow the protocol proposed by the research team.

Exclusion Criteria:

* History of participation in any study with movement representation methods.
* Subjects with impaired communication and/or compression.
Effects of Garston Tool and Neuromuscular Reeducation in Cervical Headache

Patients suffering from Cervicogenic headache have restricted range of motion and pain which in turn causes functional disability and reduced quality of life. The aim of this research was to determine the effects of Graston technique to improve range of motion, function, and reduction of pain and in patients having Cervicogenic headache

A randomized controlled trial in which Graston Technique and Neuromuscular Re-education technique would be applied on patients presenting with cervicogenic headaches by using different tools and the changes would be examined pre and post intervention. The participants fulfilling inclusion criteria would be randomly allocated to two groups. Both groups received different protocols and will be assessed on data collection tool on their first and last visit using Goniometer, Headache Disability Index (HDI), Neck pain Disability Index (NDI) and Numeric Pain Rating Scale (NPRS). Participants of both groups will be pre-tested before the application of interventional techniques and post-tested after the application of respective intervention.

Eligibility Criteria:
Inclusion Criteria:

* Age: Minimum 20years- Maximum 50 years (Male/Female)
* Unilateral pain
* Neck stiffness and ROM restrictions
* Pain exacerbated by posture and neck movements
* Pain effecting QOL
* Positive flexion-rotation test

Exclusion Criteria:

* Headache not of cervical origin
* Congenital condition of cervical spine
* Headache with autonomic involvement, dizziness or visual impairment
* Inability to tolerate the flexion rotation test
* Conditions contraindicated for graston technique
A Comparison of Hypnosis and Mindfulness on Reducing Pain in Chronic Pain Patients

The goal of this randomized controlled study is to evaluate the efficacy of an audio session of hypnosis and mindfulness meditation for providing immediate pain relief in individuals with chronic pain from Thailand. The main question\[s\] it aims to answer are:

• What effects do hypnosis and mindfulness meditation on reducing pain in chronic pain patients? Participants will

* Be randomly assigned to one of the three conditions in 20 minutes: Audio hypnosis, Audio mindfulness, A control condition
* Be blind to the study hypotheses.
* To keep the experimenter blind, the participants will not reveal what they hear in the audio.
* Pain intensity will be assessed both at pre- and post-session.
* Secondary outcomes will be assessed at pre- and post-session by the questionnaires.
* Post-session quality of sleep will be assessed by telephone interview 1 day after the session.

Primary outcome: Current pain intensity (using a 0 - 10 numerical rating scale) Secondary outcome

* Anxiety at pre and post-session using a 0-10 numerical rating scale
* 0-10 numerical rating scale assessing average, worst, and least pain intensity experienced during the sessions
* 1-5 categorical scale of treatment satisfaction assessed at post-treatment
* Quality of sleep using the Thai version of the Patient-Reported Outcomes Measurement Information System-29 (T-PROMIS-29) sleep disturbance section (4 items) at pre-session and 1 day after a session (by telephone interview)
* Duration of benefit The proposed measures of these variables have all been used successfully in prior clinical trials in samples of individuals with pain from Thailand.


Eligibility Criteria:
Inclusion Criteria:

1. Being ≥ 18 years old
2. Having chronic, non cancer pain (i.e., reporting bothersome pain for at least 50% of the days during the last three months)
3. Nociceptive, neuropathic, nociplastic pain characteristic
4. Endorsing having current pain intensity of ≥ 4 on a 0 to 10 Numerical Rating Scale
5. Being able to read, speak, and understand Thai

Exclusion Criteria:

1. Having significant hearing loss that would interfere with being able to hear the study audio
2. Having significant cognitive dysfunction, physical disability, or severe mood disturbance (e.g., significant anger or high lability) that would interfere with being able to participate in the study procedures
3. Cancer-related pain or cancer patients
Obstructive Sleep Apnea Among Somali-Americans

The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.

Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.

Eligibility Criteria:
Inclusion Criteria:

* Self-identify as Somali, African, Asian, and European descent.
* Adult males and females who are older than 18 years of age.

Exclusion Criteria:

* Minors under 18 years or adults over 100 years
* Positive pregnancy
Impact of Acetabular Fractures on Sports Performance

Acetabular fractures are complex, relatively rare lesions that are difficult to manage. Given the surgical challenge they represent, they are often managed by expert centers. The overall incidence of these fractures is around 3 fractures/100,000 persons/year.

It is now well established that the quality of the reduction obtained is an important predictive factor of the postoperative outcome in patients with displaced acetabular fractures. Obtaining an anatomical reduction, at least satisfactory, is not always easy, even in trained teams. Indeed, it can be difficult because of the structural environment. This is due to the proximity of the acetabulum to the vasculo-nervous elements, but also to the complexity of the fracture itself. The contribution of new technologies appear to be important tools to achieve this objective. Indeed, investigators have demonstrated that the use of the O-ARM imaging system (Medtronic®, Sofamor, Memphis, TN) allowed the improvement of their results.

Although they occur more frequently in the elderly population, the average incidence is maintained in the 20-59 age group. In these young populations, the fracture occurs most frequently as a result of a high-energy mechanism (road accident, more exceptionally, during a sporting activity). These patients, in the prime of their lives, are often athletic. The desire to resume sports after surgery is a powerful motivating factor for these patients. Often, it is the primary measure of surgical success from the athlete's perspective. In a previous work, Giannoudis et al. reported a 42% rate of return to activity at the previous level. The quality of the surgery is associated with the possibility of resuming sports activity after the procedure.

Thus, the objective of this work is to determine the results of acetabular surgery in a population of previously athletic patients, in particular the return to athletic performance.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 to 45 years at the time of surgery at Saint Joseph Hospital
* Patients with an isolated acetabulum fracture
* Patients with intraoperative management with O-Arm
* Patients with at least 2 years of follow-up
* French-speaking patients

Exclusion Criteria:

* Presence of pre- or post-operative neurological lesions
* Presence of associated fractures
* ASA (American Society of Anesthesiologists) score ≥ 3
* Absence of pre- and postoperative CT scans available on PACS
* Patients under guardianship or curatorship
* Patients deprived of liberty
* Patients under court protection
* Patients objecting to participation in the study
* Low preoperative physical activity (= UCLA Activity Score ≤ 5)
* Unsatisfactory criteria for surgical reduction on CT scan
A Trial Investigating the Pharmacokinetic Properties of NN1218 in Subjects With Diabetes Mellitus, Type 1

This trial is conducted in Europe. The aim of this trial is to investigate the pharmacokinetic (the rate at which the body eliminates the trial drug) and pharmacodynamic (the effect of the trial drug on the body) profiles of NN1218 in comparison with insulin aspart.


Eligibility Criteria:
Inclusion Criteria:

* Type 1 diabetes mellitus for at least 12 months
* Treated with multiple daily insulin injections or continuous subcutaneous insulin infusion (CSII) for more than 12 months.
* Body Mass Index (BMI) between 18.0-28.0 kg/m\^2 (both inclusive)

Exclusion Criteria:

* Subject who has donated any blood or plasma in the past month or more than 500 mL within 3 months prior to trial start
* Smoker (defined as a subject who is smoking more than 5 cigarettes or the equivalent per day)
* Not able or willing to refrain from smoking and use of nicotine gum or transdermal nicotine patches during the inpatient period
Knee Hinge Prosthesis Following TKA Infection

Between 2009 and January 2016, the investigators included 49 patients from four hospitals in Lyon who had a Total Knee Arthroplasty (TKA) infection and who benefited of a knee arthroplasty revision with a rotating hinge prosthesis. This retrospective and descriptive cohort aims at studying the functional results after 2 years follow up.


Eligibility Criteria:
Inclusion Criteria:

- All the patients who had a rotating hinge knee arthroplasty for septic revision after total knee arthroplasty, proved by bacteriological samples or purulent drainage at involved site or other obvious clinical signs or radiological signs of infection

Exclusion Criteria:

- Patients who benefited of a hinge prosthesis following a unicompartmental prosthesis, following a mechanical issue on a total prosthesis
Dose Systemic Lidocaine Improve the Quality of Recovery After Colorectal Endoscopic Submucosal Dissection

Endoscopic submucosal dissection (ESD) is a common procedure that requires a long procedural time. Procedure Sedation is commonly provided to alleviate patients' discomfort and facilitate the implementation of procedures. We conducted a prospective study to determine the effect of intravenous infusion of lidocaine in the cognitive domain of the postoperative quality of recovery scale on day 3 after ESD.

Colorectal cancer occurred in more than 1.9 million new cases and 935,000 deaths in 2020 and ranked third in incidence and second in mortality globally. Endoscopic submucosal dissection (ESD) is the current standard for treating large colorectal polyps and has been shown to reduce colorectal cancer-related mortality. Sedation is commonly provided to alleviate patients' discomfort and facilitate the implementation of procedures.

Lidocaine is an amide local anesthetic with analgesic, anti-hyperalgesic, and anti-inflammatory properties. Its safety in appropriate amounts has been established. The current evidence gap is whether the use of systematic lidocaine affects the quality of recovery after ESD. Thus, the aim of this study is to determine the effect of intravenous infusion of lidocaine in the cognitive domain of the postoperative quality of recovery scale on day 3 after ESD.

Eligibility Criteria:
Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) classification I-III;
2. Scheduled for endoscopic colorectal mucosal dissection.

Exclusion Criteria:

1. Patient refuses to participate;
2. BMI greater than 30;
3. Allergic or contraindication to study drugs;
4. History of chronic pain and long-term use of analgesic medication;
5. Severe arrhythmia;
6. Hepatic and renal dysfunction;
7. Any other conditions precluded study inclusion, such as cognitive impairment, pregnancy, or inability to communicate in Mandarin Chinese.
Pulmonary Embolism After Liver Resection

Major surgery is associated with a postoperative hypercoagulable state related to the surgical trauma that may lead to thromboembolic complications. To the investigators knowledge, only two series have reported the risk of PE after liver surgery with an incidence of up to 6.3% The purpose of this study is to identify the independent risk factors associated with the development of PE after elective liver surgery.


Eligibility Criteria:
Inclusion Criteria:

* Age \>18 years
* Malignant liver diseases
* Benign liver diseases

Exclusion Criteria:

* Age \<18 years
* Previous history of thromboembolic events
* Living Donor hepatectomies
Brain Healthy Soul Food Diet Intervention Among Older African Americans

The primary goal of this project is to evaluate feasibility and acceptability of the MIND+SOUL diet and its implementation. Secondary goals of this project are to evaluate cardiovascular risk profile, nutritional health status, and cognition in relation to the MIND+SOUL diet intervention.

This is a single arm trial designed to pilot test an adapted brain healthy diet intervention among older AA (n=30). Specifically, this study aims to evaluate the feasibility and acceptability of the brain healthy soul food diet intervention. As secondary outcomes, this study aims to assess body composition, cardiovascular risk, nutritional health status, and changes in cognition among older AA to form the basis of estimating power and sample size for a future full-scale randomized controlled clinical trial.

Eligibility Criteria:
Inclusion Criteria:

* Identify as African American or Black
* Age 55 and older
* English Proficient
* 1 or more of the following CVD risk factors (high blood pressure, high cholesterol, overweight/obesity with a BMI of 25 or more)
* Cognitively Normal with an AD8 \<2 (normal cognition)

Exclusion Criteria:

* No CVD risk factors
* AD8 equal to or greater than 2
* Existing diet plan prescribed by a clinician
* Non menopausal (because of DXA scan)
* No internet connection
* Uncontrolled hypertension, by history, or as indicated by supine systolic blood pressure \>165 mmHg or diastolic blood pressure \>95 mmHg at the baseline visit. If an initial blood pressure reading is higher than this, an additional attempt (at this visit or on another day) could be used before excluding a patient for uncontrolled hypertension
* Neurological diseases that impact cognition
* Other medical conditions likely to be negatively impacted by a diet change or that could confound the study data
* Unable or unwilling to provide written consent
* PI determination that study is unsafe or unsuitable
* Active depression as determined by a score of 5 or above on the PHQ9 and deemed to be clinically significant by the medical monitor
Spanish Bacteriemia Cohort 2016: Epidemiology, Clinical Management and Prognosis Factors

Bacteremia

The Hypothesis of the study are the followings:

* To demonstrate relevant epidemiologic and clinical changes with potentially impact in the management and prognosis of the patients with bacteremia.
* Since the diagnosis and management is heterogeneous between centers, we could identify a scenario to improve.
* To identify quality indicators in the management of bacteremia.
* To demonstrate that some interventions made by Bacteremia Team pose relevant impact in the prognosis of bacteremia.


Eligibility Criteria:
Inclusion Criteria:

* Every episode of bacteremia in patients older than 13 years old, confirmed microbiologically and clinically significant (presence of clinical sepsis data at diagnosis) should be prospectively included on the basis of standard criteria.
* Episodes of transient bacteremia may be included.
* Drugs will be prescribed in the usual way, according to the conditions established in the authorization. The assignment of a patient to a particular therapeutic strategy will not be decided in advance by the study protocol, but will be determined by the usual clinical practice, and the decision to prescribe a particular drug will be clearly dissociated from the decision to include to the patient in the study.

Exclusion Criteria:

* Bacteremias without clinical relevance
The Effect of Inhaled Lavender and Bergamot Oil on Anxiety and Sleep Quality in Intensive Care Patients.

This study was carried out as a randomized controlled experimental study to determine the effect of inhaled lavender and bergamot oil on anxiety and sleep quality in patients hospitalized in the intensive care unit who had undergone surgical intervention.

The universe of the research; Patients who were hospitalized in an Intensive Care Unit in Istanbul between May 2021 and October 2021, and the sample consisted of patients who met the criteria for inclusion in the study. Fifty-four patients who agreed to participate in the study and met the inclusion criteria were included. Lavender oil or bergamot oil or distilled water was administered to the patients 2 evenings by inhalation.

The universe of the research; Patients who were hospitalized in the Intensive Care Unit of a university hospital in Istanbul between May 2021 and October 2021, and the sample consisted of patients who met the inclusion criteria of the study. Data collection started after obtaining the ethics committee permission, institutional permission, and research permission from the Ministry of Health GETAT Clinical Research Department. A simple computer-assisted randomization method was used to distribute the groups homogeneously. Fifty-four patients who were hospitalized in the reanimation intensive care unit and accepted to participate in the study and met the inclusion criteria were included. The patients were randomly assigned to 3 groups of 18 people, each with distilled water, lavender oil, and bergamot oil. "Patient Information Form", "Patient Follow-up Form", "State-Trait Anxiety Inventory" and "Richard-Campbell Sleep Scale (RCUS)" were used to collect data.

Eligibility Criteria:
Inclusion Criteria:

* Over 18 years old and under 70 years old.
* Staying in the intensive care unit for at least 3 nights after surgery.
* Ability to communicate ("Richmond Agitation Sedation Scale" +1, 0, -1 points).
* Glasgow coma scale score of 9 or higher.

Exclusion Criteria:

* Having pain.
* Having any problems with smelling.
* The need for mechanical ventilation.
* Systolic blood pressure below 100 mm Hg.
* Having lung cancer, asthma and chronic obstructive pulmonary disease.
* Having allergies to known plants, flowers and related essential oils.
* Using any medication for anxiety and sleep problems.
VR Intervention to Improve Police Safety

The primary objective of this study is to demonstrate the efficacy of Floreo's police safety module (PSM) in adolescents and adults with autism spectrum disorder (ASD) by assessing improvement in police interaction skills as compared to a video modeling intervention.

Advances in virtual reality (VR) technology offer new opportunities to design interventions targeting the core deficits associated with autism spectrum disorder (ASD) and promote acquisition of skills necessary for effective navigation of challenging social situations, such as engagement with law enforcement. Researchers have explored the potential of virtual reality technology in targeting autism-related deficits, but at this time there are no evidence-based VR interventions for ASD. While most research labelled VR for the purposes of therapy has not been immersive, in recent years, the commercial introduction of head-mounted displays (HMD) and lower cost of virtual reality technology have led to greater interest in therapeutic applications of VR. As part of a mission to develop VR products for individuals with ASD, investigators will collaborate with a commercial tech start-up company, Floreo Technology, to study a mobile VR module for police safety skills. Investigators seek to evaluate the safety and feasibility of the mobile VR police safety module (PSM) and the effectiveness of the module in improving police interaction skills in adolescents and adults with ASD.

Eligibility Criteria:
Inclusion Criteria:

* Males or females age 12 to 60 years.
* Documented autism spectrum disorder (ASD) diagnosis
* Verbal Intelligence Quotient (IQ) \>/= 75 (verbal and non-verbal)
* Informed consent (if adult) or parental/guardian permission (if child or adult with diminished capacity) and, if applicable, assent

Exclusion Criteria:

* Participation in pilot virtual reality (VR) study at the Children's Hospital of Philadelphia (CHOP)
* Personal or family history of seizures or a seizure disorder
* Primary sensory impairment (e.g., blindness, deafness)
* Personal or family history of migraines
* History of vertigo
* History of strabismus, other eye muscle problems, or eye surgery
* History of concussion with hospitalization
* Diagnosis of a known genetic syndrome (e.g., Down syndrome, Fragile X syndrome)
* History of a medical condition which has affected/affects cognitive, sensory, or motor functioning (e.g., Fetal Alcohol Syndrome, brain injury, stroke, brain tumor)
* Non-English speaking
* Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures
Treatment of Aggressive Localized Lymphoma

Prospective and multicentric Phase III study, evaluation of the interest of the radiotherapy after 4 or 6 cycles of CHOP 14 R regimen of chemotherapy , patients with agressive and localized B lymphoma , age 18 to 75 years.

CHOP 14 R regimen of chemotherapy is a good standard in the treatment of agressive and localized B lymphoma.

Interest of the radiotheraphy

Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 and \< 75 years
* Diffuse B large cell lymphoma , CD 20+
* Ann Arbor stage I or II withe a bulk \<7 cm
* stage i ou II confirmed by the PET-scan
* No previously treated
* HIV negative
* Signed Informed consent

Exclusion Criteria:

* Age\< 18 and \> 75 years
* other type of lymphoma
* CD20 negative
* Ann Arbor stage \>II or bulk \> 7 cm
* HIV positive
* Contraindication to Rituximab use according to Sm PC
* Containdication to antracyclin
* cancer or history of cancer , excepted in situ cancer of the cervix or skin epithelioma
* Refusal of sign the informed consent