cyrilzakka/clinical-trials huggingface dataset:
Leap Motion In Geriatric Rehabilitation

Little is Known about the effects of leap motion based exergame therapy on different functions of elderly adults. The purpose of this study was to evaluate the effect of leap motion based exergame therapy on hand function, cognitive function and quality of life in older adults


Eligibility Criteria:
Inclusion Criteria:

* 50 years old and over,
* having adequate hand function,
* ability to follow commands,
* 24\< points in MMSE

Exclusion Criteria:

* presence of exercise contraindications
* 14 or more points on the Geriatric Depression Scale
* diagnosis of dementia
* recent (acute) hand or arm injury
Effects of Individualized Immediate Postnatal Counselling on Exclusive Breast Feeding

Breastfeeding is crucial for the health of both mothers and infants, promoting healthier populations and reducing long-term healthcare costs. To maximize these benefits, education, support, and effective policies are essential. This study aimed to evaluate the impact of immediate postpartum counseling on early initiation and exclusive breastfeeding rates in the pastoralist areas of Oromia, Ethiopia.

Hypothesis: Individualized immediate postnatal counselling improve exclusive breastfeeding practice.

Breastfeeding plays a crucial role in promoting the health and well-being of both mothers and their infants, contributing to healthier populations, and reducing long-term healthcare costs. Encouraging breastfeeding through education, support, and policies is essential for maximizing these benefits. This study aimed to evaluate the impact of immediate postpartum counseling on early initiation of breastfeeding rates and exclusive breastfeeding in Bule Hora and Yabelo Hospitals. A cluster randomized single-blinded trial was conducted on 224 pregnant women (112 for the intervention group and 112 for the control group) from January 1, 2023, to April 30, 2023. The effect of immediate postpartum counselling and its associated variables on early initiation and exclusive breastfeeding practices were evaluated using multiple logistic regressions. A p-value of less than 0.05, a 95% confidence interval, and an adjusted odd ratio were used to determine statistical significance.

Eligibility Criteria:
Inclusion Criteria

* Gave birth by spontaneous vaginal delivery
* Residents of either Yabelo or Bule Hora town hospital
* willing to participate in the study Exclusion Criteria
* Seriously ill and planned to move during the study period
* Stillbirth
* Neonatal death
* Gave birth cesarean delivery
The Influence of Psychological Interventions Upon Disease Progression in HIV-infected Patients Receiving no Medication

This study examines the hypothesis that psychological interventions have beneficial effects on quality of life including psychological well-being and disease progression in early HIV patients recieving no medication.

Hypothesis: This investigation is based upon the hypothesis that psychological intervention may counteract the detrimental effects of stress both on psychological well-being and on general health.

Background: HIV infection may be considered to be a life-long biological and psychological stressor leading to detrimental outcomes associated with disease progression. Stress reduction in these patients may have beneficial effects through delaying disease progression via the proposed interactive psycho-neuro-endocrine-immune network.

Inclusion Criteria:

HIV infected individuals CD4 T-cell counts above 200 cells/mcl Receiving no anti-retroviral drugs Individuals who signed the informed consent form

Investigative approach: Self-hypnosis and a Japanese non-touching, laying-on-of hands-like technique, called Johrei, were used to investigate the effects of psychological intervention upon immune parameters (especially in CD4 counts) associated with disease progression along with phenomenological associations between stress perception and stress hormone levels in HIV-infected patients receiving no medication.

Eligibility Criteria:
Inclusion Criteria:

* HIV infected
* CD4 T-cell counts above 200 cells/mcl
* Signed the informed consent form

Exclusion Criteria:

* receiving anti-retroviral drugs
Clinical Trial to Investigate the Pharmacokinetic Drug Interaction Between Udenafil and Bosentan After Oral Administration

This study is designed to investigate the pharmacokinetic drug interaction and safety after oral administration of Udenafil(DA-8159) and Bosentan in healthy volunteers.

Design: Randomized, open-label, multiple-dose, three-treatment, three-period, six-sequence, Williams design

Investigational Product: Udenafil, Bosentan


Eligibility Criteria:
Inclusion Criteria:

* healthy volunteers between the ages of 20 to 45 years old within the range of BMI between 18.5 and 25(Body Mass Index)
* having neither congenital/chronic diseases nor pathological symptoms/findings as results of medical examination
* doctor determines to be suitable as subjects within 4 weeks ago before administration

Exclusion Criteria:

* Hypersensitivity(or history of hypersensitivity) to Udenafil, Bosentan and PDE5 inhibitors
* Active Liver Diseases or exceed 1.25 times the normal range of AST, ALT
* Gastrointestinal diseases or surgeries that affect absorption of drug
* Excessive drinking(exceed 210g/week) and excessive caffeine(exceed 5cups/day)
* Smoking over 10 cigarettes per day
* pregnant or nursing female volunteers
Effectiveness of Ear Acupuncture to Improve Insomnia in Women With Breast Cancer

The aim of this clinical study is to investigate the extent to which ear acupuncture has an effect on insomnia in women with breast cancer. It will be investigated whether changes in sleep quality, fatigue, quality of life, stress, and psychological well-being can be achieved. In addition, a proinflammatory cytokine will be meassured.


Eligibility Criteria:
Inclusion Criteria:

* Histological diagnosed non-metastatic breast CAs (TNM stage I-III)
* Existing insomnia (difficulty falling asleep or sleeping through on at least 3 days per week for at least 3 months) according to the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM 5).
* willingness to participate in the study (at least 8 out of 10 treatments)
* Signed informed consent

Exclusion Criteria:

* Ongoing or planned chemotherapy, radiation, follow-up treatment or reconstructive plastic surgery during the study period
* Severe physical or psychopharmacologically treated psychiatric comorbidity that prevents a patient from participating in the study
* Pregnancy
* Participation in other clinical trials with behavioural, psychological or complementary medical interventions during the study period
* Regular use of barbiturates, antidepressants or other sleep-inducing drugs, drug abusus, alcoholism
EarlySense Monitoring Device Evaluation on CHF Patients

CHF patients will be monitored using EarlySense ES-16 device and will simultaneously fill diaries and log their weight daily. The data collected and analyzed by the ES-16 device will be correlated with the CHF status data.


Eligibility Criteria:
Inclusion Criteria:

* Age over 45 years old
* CHF class II or III with LVEF\<40%
* Hospitalized at least once for CHF deterioration over previous 12 month period
* Able and willing to cooperate with this trial for at least a 3 month period
* Home close to participating center

Exclusion Criteria:

* Recent (within 3 month) admission to ICU or CC-ICU due to severe CHF episode requiring artificial ventilation
* Asthma or COPD
Evidence-Based Orthotics Prosthetics Practices

The main purpose of our research is; The aim of this study is to investigate the views of health professionals in the field of Orthotic Prosthesis in Turkey on Evidence-Based Orthotic Prosthesis Practices. This research is important in revealing the perspective of health professionals in this field on evidence-based orthotic prosthesis applications. No such study has been found in the literature in the field of Orthosis and Prosthesis. In this respect, it aims to bring a new perspective to the literature.

Three data collection tools will be used as data collection methods for the research. These data collection tools; demographic information form, Health Sciences Evidence-Based Practice Survey and Information Literacy Self-Efficacy Scale. Surveys will be sent to participants to be filled out via Google Forms.

Inclusion criteria: Having been working in hospitals, clinics, academic units, etc. in Turkey for at least 6 months. Being able to read and write Turkish. Exclusion criteria; Those who graduated in the field of Orthosis and Prosthesis and work in other clinics and units.

The data will be evaluated in the statistical package program IBM Statistical Package for the Social Sciences Statistics 26.0 (IBM Corp, New York, USA).

To determine the sample size in the study, G\*Power 3.1.9.4 software was used to calculate the number of people to take part in the study. The effect size of the study was determined as 134 participants with 80% statistical power and 5% significance level. Our research will be conducted between December 2023 and June 2024.

Eligibility Criteria:
Inclusion Criteria:

* Inclusion Criteria: Having been working in hospitals, clinics, academic units, etc. in Turkey for at least 6 months.
* Being able to read and write Turkish

Exclusion Criteria:

* Those who graduated in the field of Orthosis and Prosthesis and work in other clinics and units
Heart Muscle Viability and Remodeling in Individuals Post-Heart Attack

The purpose of this study is to assess the effect of heart muscle viability on left ventricular (LV) remodeling after a heart attack; to explore the relationships between retained viability of the area of tissue death (infarct zone), LV remodeling, response to the Occluded Artery Trial (OAT) intervention, and response to late percutaneous coronary intervention of the infarct related artery (IRA).

BACKGROUND:

Coronary heart disease is a major health problem in the United States. It is estimated that in 2003, more than 600,000 Americans had a new heart attack, and more than 400,000 experienced a recurrent heart attack. Up to 40% of individuals with a new or recurrent heart attack will show a complete occlusion, or blocking, of the IRA on follow-up angiography. Many people with an occluded IRA post-heart attack are at risk for progressive LV remodeling in the heart, which can lead to congestive heart failure.

The NHLBI-funded OAT study is testing the hypothesis that opening an occluded IRA 3 to 28 days following a heart attack will reduce the composite endpoint of mortality, recurrent heart attack, and New York Heart Association class IV heart failure over a three-year follow-up period. OAT has enrolled approximately 1,100 participants at 240 centers in 24 countries. Among the mechanisms proposed to explain the benefit of late revascularization, recovery of LV function and attenuation of LV remodeling due to restoration of blood flow to viable myocardium, or heart muscle, is the most plausible.

DESIGN NARRATIVE:

An estimated 200 individuals who have had a heart attack will be enrolled in this study. The primary aims of this study are the following: 1) to test the hypothesis that participants who demonstrate preservation of viability within the infarct zone will have less progressive remodeling compared to participants exhibiting predominant infarct, and 2) to test the hypothesis that preservation of viability will modify the treatment effect of randomization to late revascularization in participants with an occluded IRA 3 to 28 days after the heart attack. All participants will have resting gated Tc-99m sestamibi SPECT imaging at baseline, and again 1 year later. Parameters of baseline viability within the infarct zone, and serial measures of LV volume change and function will be centrally assessed by the Cardiac Imaging Core Laboratory at Tufts Medical Center. The major study endpoint to address the hypotheses will be serial change in LV end-diastolic volume, based on the degree of preservation of viability within the defined infarct zone. Sample size calculations will be based on data evaluated by the same group from a similar number of participants studied at a similar number of clinical sites.

Eligibility Criteria:
Inclusion Criteria:

* Has experienced a heart attack 3 to 28 days prior to study entry
* Has an occluded IRA at catheterization
Soy and Brain Vascular Function

Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function. Supported by the statement from the American Heart and American Stroke Association that healthy plant-based diets, which consist of soy foods, protect against cognitive decline, we now hypothesize that soy-induced changes in glucose metabolism cause beneficial effects on brain vascular function thereby improving cognitive performance. The primary objective of this intervention study is thus to evaluate in elderly men and women the effect of a 16-week soy intervention on cerebral blood flow, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI) perfusion method Arterial Spin Labeling (ASL). Cerebral blood flow is a robust and sensitive physiological marker of brain vascular function. Secondary objectives are to examine effects on glucose metabolism using the oral glucose tolerance test and cognitive performance as assessed with a neurophysiological test battery.


Eligibility Criteria:
Inclusion Criteria:

* Aged between 60-70 years
* BMI between 20-30 kg/m2
* Fasting plasma glucose \< 7.0 mmol/L
* Fasting serum total cholesterol \< 8.0 mmol/L
* Fasting serum triacylglycerol \< 4.5 mmol/L
* Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 100 mmHg
* Stable body weight (weight gain or loss \< 3 kg in the past three months)
* Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study
* No difficult venipuncture as evidenced during the screening visit

Exclusion Criteria:

* Allergy or intolerance to soy
* Current smoker, or smoking cessation \< 12 months
* Diabetic patients
* Familial hypercholesterolemia
* Abuse of drugs
* More than 3 alcoholic consumptions per day
* Use of soy products or dietary supplements known to interfere with the main outcomes as judged by the principal investigators
* Use medication to treat blood pressure, lipid or glucose metabolism
* Use of an investigational product within another biomedical intervention trial within the previous 1-month
* Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis
* Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident
* Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)
Training Load Management in Three Professional Tennis Players During COVID-19 Lockdown: a Case Series Study

Research describing training load management during COVID-19 enforced home training in professional tennis players is lacking. Therefore, the main objective of this case series is to describe in detail the training load management and progression of three professional tennis players before, during and after COVID-19 pandemic lockdown.

Research describing training load management during COVID-19 enforced home training in professional tennis players is lacking. Therefore, the main objective of this case series is to describe in detail the training load management and progression of three professional tennis players before, during and after COVID-19 pandemic lockdown.

Eligibility Criteria:
Inclusion Criteria:

* tennis players training in argentina

Exclusion Criteria:

-
Psycho-oncological Intervention Through Counselling in Patients With Differentiated Thyroid Cancer in Treatment With Radioiodine

Diagnosis and treatment of differentiated thyroid carcinomas cause anxiety and depression. Additionally, these patients suffer hormonal alterations, associated with psychological symptoms (changes in mood, emotional instability, memory loss, etc.). This study aims to evaluate the effectiveness of a psycho-oncological intervention based on Counselling to reduce anxiety and depression related with the treatment in patients with differentiated thyroid carcinomas.

A non-randomized controlled study, with two groups (experimental, n=37, and control, n=38) and baseline and post-treatment measures was designed. Patients in experimental group received a psycho-oncological intervention based on Counselling in addition to the standard treatment. The independent variable was the assigned group and the dependent one was the evolution of anxiety and depression, analyzed separately, both evaluated using HADS. Other relevant covariables related with quality of life were also analyzed using SF-36 and PGWBI scales.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with DTC (differentiated thyroid carcinoma)
* Initial treatment by total thyroidectomy
* Treatment with RIT after physiological stimulation of thyroid-stimulating hormone (TSH) by suppression of hormone replacement therapy (HRT) for a month
* Fluid Spanish speaker
* 18 years or over
* Obtaining informed consent

Exclusion Criteria:

* Diagnosis or treatment for psychiatric disorders
* Any type of illness with serious impact in medical condition
* Inability to communicate or to process the information
Anterior Lamellar Recession vs Bilamellar Tarsal Rotation in Upper Lid Cicatricial Trichiasis

in recent years there has been a significant shift from this destructive procedure to a reconstructive procedure such as Anterior Lamellar Recession (ALR) and Bilamellar Tarsal Rotation (BLTR).


Eligibility Criteria:
Inclusion Criteria:

* patients with upper lid cicatricial trichiasis that requires surgical intervention

Exclusion Criteria:

* Refusal of the patients.
* Associated entropion., 3) Severe ocular surface disease.
* Previous eyelid surgery.
* Associated lid laxity.
* Lack of adequate follow-up
Efficacy of an Osteopathic Treatment for Mechanical Sucking Dysfunctions in Newborn

Breastfeeding is the physiological and recommended way of feeding newborns as indicated by the World Health Organization, Health Canada and the politics of perinatality 2008-2018 in Quebec. Despite these, mothers who exclusively breastfed their babies are rare. According to Statistics Canada, the first month of life is the most at risk time to wean because of technical difficulties (53% of weaning) including mechanical issues. In Quebec city, despite a supportive network of health care professionals including lactation consultant, many babies are weaned. Lactation consultant are often feeling helpless when facing these mechanical difficulties.

The purpose of this study is to determine the efficiency of an osteopathic treatment for newborns presenting breastfeeding mechanical difficulties. The investigators' hypotheses is that an osteopathic treatment integrating in the usual care is more efficient than usual car alone to help healing mechanical breastfeeding issues.

The investigators propose a randomized clinical trial on a sample of 90 babies (45 in each group), under six weeks, presenting sucking dysfunctions, in Quebec city (Canada). The control group will receive usual care with a lactation consultant and the intervention group will receive usual care plus an osteopathic treatment. It is a simple blind clinical trial: the osteopath finds out, prior to evaluating the patient, what intervention should be delivered to the baby (assessment alone or standardized osteopathic treatment for infant).

The results will ultimately lead to improvements in the existing knowledge on the fields of osteopathy and lactation support, allowing implementation of osteopathic care in the perinatal network.


Eligibility Criteria:
Inclusion Criteria:

* healthy term newborn,
* mechanical suckling dysfunction, assessed by lactation consultant or midwives or healthcare professionals with breastfeeding experience.

Exclusion Criteria:

* breastfeeding difficulties from mother (hypogalactia, breast hypoplasia, medication),
* twins or more,
* tongue-tie or lip tie pending for surgical treatment,
* previous or current bodywork (chiropractic, osteopathy, physiotherapy, ergotherapy, craniosacral therapy).
Precision Medicine Randomized Clinical Trial Comparing Molecular Tumor Board Assisted Care to Usual Care

This trial will compare Molecular Tumor Board (MTB) assisted care to usual care for patients who have newly diagnosed histologically or cytologically confirmed stage IIb-IV Non-Small Cell Lung Cancer (NSCLC) and are planning to undergo treatment for their cancer.


Eligibility Criteria:
Inclusion Criteria:

* Clinically suspected or histologically confirmed stage IIb-IV NSCLC who are planning to undergo treatment
* No prior systemic therapies for NSCLC, with the exception of adjuvant therapy for early stage NSCLC. Prior surgery and/or radiation is allowed.
* Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with targeted therapy, in the opinion of the treating physician.
* Pregnancy
Ultrasound Evaluation of Abdominal Muscle Thickness During Mechanical Ventilation

Weakness of respiratory muscles is frequent after several days of mechanical ventilation. Thereby an acquired diaphragm weakness has been demonstrated, linked to an atrophy which may be identified by a decrease of muscle thickness in echography. This study aims to evaluate with ultrasound the variation of thickness of abdominal muscles after 7 days of mechanical ventilation.

Weakness of respiratory muscles is frequent after several days of mechanical ventilation. Thereby an acquired diaphragm weakness has been demonstrated, linked to an atrophy which may be identified by a decrease of muscle thickness in echography. Weakness of expiratory muscles is also frequent after 7 days of mechanical ventilation, however his cause is not clear: is it present at admission notably in elderly patients, or acquired on mechanical ventilation ? Ultrasound allows to measure the thickness of abdominal muscles which correlates with their strength. This study aims to evaluate with ultrasound the variation of thickness of abdominal muscles after 7 days of mechanical ventilation.

Eligibility Criteria:
Inclusion Criteria:

* Patient affiliated or entitled to a social security plan
* Expected duration of mechanical ventilation \> 7 days
* Trusted person/relative who has signed a consent to participate in the study

Exclusion Criteria:

* Patient with a pre-existing neuromuscular pathology
* No access to ultrasound Windows (dressing, drainages...)
* Patient transferred from another intensive care unit
* Patient Under guardianship or curators