cyrilzakka/clinical-trials huggingface dataset:
Effectiveness on Family Cohesion and Happiness of Using Social Media to Enhance Happiness Accounts for Late-Stage Cancer Patients and Their Families

The study period is from September 1, 2024, to December 31, 2025. The subjects are cancer patients from the medical center of this hospital. A block randomization will be used to assign 100 patients to the experimental group and 100 patients to the control group, totaling 200 patients. During the study process, questionnaires and medical records of the subjects will be collected. The experimental group will receive the social media "Happiness Ledger" intervention, while the control group will receive routine treatment. Questionnaires will be collected from both groups before and after the intervention.


Eligibility Criteria:
Inclusion Criteria:

-

Inclusion Criteria for Advanced Cancer Patients:

1. Patients diagnosed with stage III or IV cancer by a specialist physician.
2. Patients who agree to participate in the study after being informed about the research.
3. Patients who are conscious and able to communicate in Mandarin or Taiwanese.
4. Patients aged 20 years or older.
5. Patients with no history of mental illness.

Inclusion Criteria for Family Members:

1. The primary caregiver of a patient diagnosed with stage III or IV cancer by a specialist physician.
2. The primary caregiver who has a blood, marital, or cohabitation relationship with the patient.
3. Family members who agree to participate in the study after being informed about the research.
4. Family members who are conscious and able to communicate in Mandarin or Taiwanese.
5. Family members aged 20 years or older.
6. Family members with no history of mental illness.

Exclusion Criteria:

-

Exclusion Criteria for Advanced Cancer Patients:

1. Patients in the experimental group and control group who reside in the same ward.
2. Patients who share a ward with subjects already included in the study.
3. Patients involved in ongoing medical disputes.
4. Patients who cannot understand the study explanation due to language or cognitive impairments.
5. Patients with a life expectancy shorter than the planned study duration.

Exclusion Criteria for Family Members:

1. Family members who do not have direct living or caregiving contact with the patient.
2. Family members who cannot visit the patient regularly or participate in the study.
3. Family members who cannot understand the study explanation due to language or cognitive impairments.
4. Family members with significant visual or hearing impairments who do not use assistive devices and cannot resolve communication issues.
5. Family members who cannot make independent decisions.
A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012)

This 5-part study will evaluate the safety, tolerability, and pharmacokinetics of two formulations of MK-0517 (with and without polysorbate 80) and aprepitant in healthy adults. Parts I to IV of this study will examine different doses of MK-0517 as well as two different formulations of MK-0517 (with and without polysorbate 80). Part V of the study will compare single doses of intravenous non-PS80 MK-0517 to oral 125-mg capsule of aprepitant. The primary hypothesis for Part V of the study is that a single intravenous dose of 100-mg or 115-mg MK-0517 is area under the plasma-time curve (AUC) equivalent to that of the 125-mg oral aprepitant capsule in young healthy participants.


Eligibility Criteria:
Inclusion Criteria:

* Subject is neither grossly overweight nor underweight for his/her height and body build
* Subject is in good health -Subject is a nonsmoker
* Subject is willing to avoid excessive alcohol consumption for the duration of the study
* Subject is willing to avoid strenuous physical activity (i.e. unaccustomed weight lifting, running, bicycling) for the duration of the study
* Subject agrees to refrain from consumption of grapefruit (and grapefruit products) before and during the study

Exclusion Criteria:

* Subject has a history of multiple and/or severe allergies to drugs or food
* Subject has donated blood or taken an investigational drug in another clinical trial within the last 4 weeks
* Subject has an infection, including Human immunodeficiency virus (HIV) infection
* Subject is a regular user of any illicit drug
* Subject consumes excessive amounts of alcohol
* Subject drinks excessive amounts of coffee, tea, cola or other caffeinated beverages
* Subject currently uses on a regular basis, any prescription or non prescription medications
Cultural Adaptation of Sedentary Behavior Questionnaire and Reliability, Validity Research of Turkish Version

The aim of this study is to adapt the Sedentary Behavior Questionnaire (SBQ) into the culture of Turkish and to work on the reliability and validity of it in healthy individuals between the ages of 18-64. The permission was obtained via mail from Dori Rosenberg, who is the developer of the questionnaire, for its Turkish adaptation. SPSS package programme will be used in the analysis,

The aim of this study is to adapt the Sedentary Behavior Questionnaire (SBQ) into the culture of Turkish and to work on the reliability and validity of it in healthy individuals between the ages of 18-64. Original form has nine questions but Spanish version of it had eleven questions so the investigators will translate Spanish version of SBQ. At first step by using a forward-backward translation method, a translation and adaptation process will be performed. At second step the validation process will be performed in a total of 200 healthy subjects aged between 18-64 years. Subjects will fill sociodemographic information form, International Physical Activity Questionnaire Short Form, and SBQ Turkish version ( at baseline and after seven days). Cronbach's alpha values, confirmatory factor analysis (CFA) will be evaluated for the reliability, construct and convergent validity.

Eligibility Criteria:
Inclusion Criteria:

* Being a healthy individual between the ages of 18-64.
* No problem of reading, writing or understanding Turkish.

Exclusion Criteria:

* Severe trauma in the last 6 months.
* Having orthopedic, neurological, cardiovascular problems that restricts ambulation.
The Size of the Gastric Remnant as Determinant for Delayed Gastric Emptying After Whipple Resection.

A small gastric remnant after whipple resection improves gastric emptying and therefore prevents the development of delayed gastric emptying.

Every patient submitted to a whipple resection and at the same time present with characteristics suggestive of minimal risk for leakage from the pancreaticojejunostomy will be included in the study. At the time of reconstruction the patient will be randomized to either conventional size of the stomach or to a subtotal gastrectomy containing a small upper gastric pouch only.

Eligibility Criteria:
Inclusion Criteria:

All patients undergoing whipple procedure with preoperative assignment as low risk for leakage from the pancreaticojejunal anastomosis.

* Signed informed consent.

Exclusion Criteria:

* High and intermediate risk pancreaticojejunal anastomosis. Unwillingness to participate.
The Effectiveness of Music on Pain and Anxiety in IUD Insertion

Although intrauterine devices (IUDs) are a highly effective contraceptive method, fear of pain during insertion is one barrier to use. A review of literature reveals little investigation of interventions for anxiety management during the procedure. Furthermore, evidence of non-pharmacological interventions for both anxiety and pain management is limited. Music has been shown to be effective at reducing anxiety and pain in a variety of contexts, however to the investigators' knowledge, its effectiveness for anxiety and pain relief during the IUD insertion procedure has not been formally examined. This study will therefore examine the effectiveness of listening to music on anxiety and pain during IUD insertion.

The study is a randomized controlled trial of patients at least 16 years of age undergoing an IUD insertion. The experimental group will receive music, self-selected, with a music-playing device prior and during the procedure and the control group will receive standard care. Data for pain and anxiety will be collected prior to the procedure, and during, and after IUD insertion. In addition, a post-procedure questionnaire will be given to patients and providers to ask about satisfaction and acceptability of the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Sufficient understanding of English to complete questionnaires
* Women who will attend the clinic for an IUD insertion and accept to participate in the study

Exclusion Criteria:

* Women with chronic pain
Correlation Between Triglyceride Glucose Index and Residual SYNTAX Score in STEMI Patients Undergoing PPCI

The goal of this study To check correlation between triglyceride glucose (TyG) index and residual SYNTAX score (RSS) in STEMI patients undergoing PPCI.

2. Impact of both TyG index and RSS in STEMI patients undergoing PPCI on LV EF recovery after 3 months using LV speckle tracking.

3. Impact of RSS and TyG index in STEMI patients undergoing PPCI on short term MACE at 3 months duration.

ST-elevation myocardial infarction (STEMI) is known as a life-threatening complication of coronary artery disease (CAD) and it is one of the leading causes of death all over the world. Primary percutaneous coronary intervention (PPCI) of the culprit vessel in patients with STEMI is standard clinical practice .

At the time of PPCI, 40-65% of the patients exhibit one or more concomitant coronary lesions (i.e., multivessel disease (MVD)). The presence of narrowed coronaries other than those related to index ischemia in patients with STEMI is suggested as a feature associated with adverse clinical outcomes .

The recently developed residual SYNTAX Score (RSS) (developed 2012 and validated in 2013) is an objective, quantitative measure of the degree and complexity of residual stenosis after percutaneous coronary intervention (PCI) .It was developed to quantitatively assess the degree and complexity of residual stenoses, based on recalculating the SYNTAX score from coronary angiography after PCI . Higher RSS has been associated with worse outcome in patients undergoing angiography-mediated PCI .

Insulin resistance (IR) is an important risk factor for the development of CAD . It is defined as a state in which a greater than normal amount of insulin is required to elicit a quantitatively normal response .

Previous studies have shown an independent association between IR and CVD. IR is tightly associated with increased cardiovascular morbidity and mortality by adversely modifying well-established cardiovascular risk factors such as dyslipidemia and hypertension and by causing endothelial dysfunction .

Eligibility Criteria:
Inclusion Criteria:

* All patient who are between 18 and 80 years old who present to our hospital (Assiut university heart hospital) with STEMI and eligible for primary PCI as treatment of choice according to guidelines, will be included in our study.

Exclusion Criteria:

* Patient who refuse to undergo revasculariztion using primary PCI.
* Patient who will die before withdraw of laboratory blood sample.
* Patient with previous PCI and/or CABG.
* Patient with underlying co-morbidity with life expectancy less than 1 year (end stage liver disease, end stage renal disease on regular dialysis, active malignancy).
* Patient with failed canalization of infarct related artery.
* Patient referred to CABG after angiography.
* Patient who is unconscious after cardiac arrest .
Response Prediction to Neoadjuvant Chemoradiation in Esophageal Cancer Using Artificial Intelligence & Machine Learning

In esophageal carcinoma, neoadjuvant concurrent chemo-radiotherapy (NA-CCRT) followed by surgery is the current standard of care and ample evidence has accumulated supporting the view that complete pathological response (pCR) is a positive prognostic marker for improved outcomes. Predicting the probability of achieving pCR prior to neoadjuvant treatment could permit modification of treatment protocols for those patients unlikely to achieve pCR.

Radiomics is a new entrant in the field of imaging where specific features are derived from the intensity and distribution pattern of pixels based on a region-of-interest (ROI). The features thus extracted can then be used for prediction modelling similar to other -omics datasets. Preliminary investigations examining its utility have been performed and its applications have thus far focused on screening and survival prediction after treatment. Due to the multi-dimensional nature of data extracted using radiomics, Artificial Intelligence (AI) methods are ideally suited for analysing and modelling radiomic features.

Machine Learning (ML) and Deep Learning (DL)\[utilising Convolutional Neural Networks (CNN)\] are both part of the AI framework. In contrast to ML, DL is a new entrant and has been utilised by some medical researchers for modelling using prediction-type algorithms. Besides significantly reducing the workflow associated with Radiomics-based research, feature engineering and modelling using DL are immune to the effects of incorrect ROI delineation. However, the main limitation of DL is the 'blackbox' effect, in which the underlying basis of a CNN is not known. This has been mitigated in part by the visualisation of activation maps directly on the image dataset to prove biological plausibility of predictions. The comparative performance of both types of modelling is also not known.

Our objective is to investigate pCR probability in our study population using radiomics-based ML and AI-based modelling. We will also investigate the comparative performance of both modelling techniques. For DL based prediction modelling, we will attempt to provide biological plausibility on the basis of activation maps.


Eligibility Criteria:
Inclusion Criteria:

* ECOG Performance Status: 0-2
* Patients with histopathological or cytopathological confirmed malignancy of the esophagus
* Histology: Squamous Cell Carcinoma and Adenocarcinoma
* Patients should have received NeoAdjuvant Concurrent Chemoradiation (NACCRT) followed by Surgery
* All therapeutic interventions (Radiotherapy, Chemotherapy \& Surgery) delivered within participating institutions
* At least one pre-NACCRT DICOM imaging dataset (HRCT/ 18-FDG PET-CT/ Radiotherapy planning CT) for each patient

Exclusion Criteria:

* Patients with any metallic implants in the region of interest
* Patient with locally advanced disease or metastatic disease (T4 disease, Fistula, metastases)
* Patients with prior history of radiotherapy in the same region
* Patients developing a second malignancy in the esophagus
Autologous Mesenchymal Stromal Cell Therapy in Heart Failure

It is a single centre, randomised controlled study of the effect of NOGA-guided direct intramyocardial injection of mesenchymal stromal cells on the development of new myocardium and blood vessels in patients with heart failure.

Stem cells will be obtained from the bone marrow and culture expanded for 6 - 8 weeks before injected into the myocardium.

The patients will be followed with safety, clinical, MRI and CT endpoints for 1 year.

The primary objective is to investigate the regenerative capacity of direct intra-myocardial injection of mesenchymal stromal cells in patients with reduced left ventricular EF (≤45%) and heart failure NYHA 2-3.

A total of 60 patients with will be enrolled in the study and randomised 2: 1 to cells or placebo (saline).

The patients will be followed for 12 months. The primary endpoint is changes in left ventricle end-systolic volume (LVESV) at 6 months follow-up.

The secondary endpoints are changes in left ventricular ejection fraction (LVEF), end-diastolic volume and end-systolic mass at 6 months follow-up.

Other secondary endpoints are NYHA, CCS, Kansas City Cardiomyopathy Questionnaire (KCCQ), 6 min walking test, and major adverse events endpoints: all-causes death, cardiovascular death, and hospitalization for worsening heart failure and MI at 12 months follow-up.

Eligibility Criteria:
Inclusion Criteria:

* EF \< 45 %
* NYHA 2 - 3

Exclusion Criteria:

* Acute coronary syndrome within last 6 weeks.
* Pregnancy
* FEV1 \<1.0
* Cancer
* Any severe disease which could interfere with the treatment or the outcome
Determining in Vitro Properties of Epithelial Cells From Individuals With Genetic Variants Associated With Idiopathic Pulmonary Fibrosis

The investigators are trying to understand the role of specific genes in the function of airway surface cells. The investigators know that there are some common genetic markers that are associated with various lung diseases. However, most people with these genetic markers never develop any evidence of lung disease, so it is not understand how or if these markers play a role in disease. Investigators are asking healthy people to provide three (3) tubes of blood as well as a sample of cells from their nose. Investigators will use the blood sample to provide genetic information (specifically, presence or absence of alleles known to be associated with pulmonary fibrosis). Nose cells from individuals with the genetic markers that investigators are studying will be grown in the the lab to allow investigators to learn more about how the cells respond to various forms of environmental stress, such as exposure to cigarette smoke. The goal of this study is to understand how specific genes affect airway cell function.


Eligibility Criteria:
Inclusion Criteria:

1. Age greater than 18 years of age
2. Ability to provide informed consent
3. Patent bilateral nares

Exclusion Criteria:

1. Significant nasal or sinus disease precluding nasal brushing
2. A history of or ongoing epistaxis (nose-bleeding)
3. Acute upper respiratory illness
4. Ongoing treatment of respiratory or sinus illness with antibiotics
5. Pregnancy
6. Age less than 18 years
7. Infection with human immunodeficiency virus (HIV) or viral hepatitides (Hepatitis B, Hepatitis C)
8. Prior volunteer for the same study
9. Known diagnosis of cystic fibrosis or other ciliary disorder (example: primary ciliar dyskinesia)
10. Treatment with anticoagulants (examples: warfarin/coumadin, low molecular weight heparins, direct thrombin inhibitors such as dabigatran, anti-platelet agents such as P2Y12 inhibitors like clopidogrel and prasugrel, aspirin, ticagrelor, or factor Xa inhibitors such as rivaroxaban)
11. Known thrombocytopenia (example: immune thrombocytopenic purpura)
12. Ongoing chemotherapy
13. Known platelet dysfunction or bleeding diathesis/hemophilia
CAN CREATINE SUPPLEMENTATION IMPROVE PERFORMANCE in ROCK CLIMBERS?

Why? Bouldering is a form of rock climbing that comprises short rock climbs of approximately three metres in height. Approximately 35,000 people participate in bouldering the UK, 200 of whom do so competitively. Bouldering requires a high strength to body weight ratio. Creatine is widely used in other sports as a nutritional supplement to increase muscle mass, strength and exercise tolerance. Whether Creatine can enhance performance of elite boulderers and in other disciplines of climbing is not known. Answering this question is important to identify safe and legal performance enhancing aids to enable recreational and competitive boulderers and climbers to maximise their personal and competitive potential.

What? This study will investigate a nutritional supplement, Creatine monohydrate (the "active supplement"), and compare its efficacy to a nondistinguishable and similar calorie content supplement, fructose (the "placebo"). Who? Elite boulderers from the Great Britain (GB) Bouldering Team will be invited to take part. If recruitment is slow, highly accomplished climbers from the North Wales region will also be invited.

Where? The study data collection visits will be completed at Bangor University. The supplementation will be completed by the participants at home.

How? The study will utilise a randomised placebo controlled trial design. Randomised means that participants will be allocated to receive the active supplement OR the placebo by chance. The study will last 18 weeks. Participants will visit the University for familiarisation (week 4) and again at baseline (week 0). The tests will include assessment of body weight, a whole body xray scan to determine skeletal muscle mass (at week 0 and 13 only), tests of upper body and core muscle strength, and a test of climbing-specific performance during a simulated bouldering competition.

Then, depending on group allocation, 5 g of the active supplement or placebo will be consumed four times per day for five days (the "loading phase"). Thereafter the dose will be reduced to 3 g once per day for twelve weeks (the "maintenance phase"). The supplement and the placebo will be mixed with flavoured water and consumed at meal and snack times.

Finally, at study cessation (week 13), the University visit will be repeated. The research is being funded by Bangor University. The creatinine and placebo supplements are being supplied by a nutritional company that has no influence over the publication of the results.


Eligibility Criteria:
Inclusion Criteria:

* membership of the GB Bouldering Team or climbing at grade above F6c

Exclusion Criteria:

* evident or previously diagnosed kidney damage
Peer Support for Severe Mental Disorders

The purpose of this study is to determine wether peer support is effective for the treatment of people with severe mental illness.

A randomized controlled multi center trial is conducted, where patients receive usual care in the control group and usual care with additional peer support for 6 month in the intervention group. Psychosocial outcome criteria are collected pre intervention, after 6 month intervention and at one year follow up. Days till hospitalization and days spent in hospital are collected for one year before recruitment and one year after recruitment.

Eligibility Criteria:
Inclusion Criteria:

* clinical diagnosis of schizophrenia, unipolar depression, bipolar disorder, personality disorder

Exclusion Criteria:

* primary clinical diagnosis of addiction
Electrophysiological Reactivity Due to Mobile Phone Radiation

The main objective of this study is to investigate whether radiofrequency electromagnetic radiation, induced by a dialing mobile phone placed on the body, causes a change in electrophysiology.

The aim of this study is to investigate whether placement of a 3G dialing mobile phone causes direct changes in EEG activity compared to the placement of a sham phone. Furthermore, it is investigated whether placement of the mobile phone on the ear or the heart results in different outcomes. The subjects are measured twice: on one of the two days the mobile phone is attached to the ear, the other day to the chest. In this single-blind, cross-over design, assessments in the sham phone conditions are conducted directly preceding and following the mobile phone exposure. During each assessment, EEG activity and radiofrequency radiation are recorded jointly. Delta, theta, alpha, slowbeta, fastbeta, and gamma activity are computed. The association between radiation exposure and the EEG is tested using multilevel random regression analyses with radiation as predictor of main interest.

Eligibility Criteria:
Inclusion Criteria:

* female aged between 18 - 30 years

Exclusion Criteria:

* cardiac or brain disorder
* pregnancy