cyrilzakka/clinical-trials huggingface dataset:
Evaluation of the Pravalence of Rathke's Cleft Cyst of Children Under 15 Years

The goal of the study was to evaluate the pravalence of Rathke's Cleft Cyst of children under 15 years of age and demonstrate that their prevalence is higher than for patients over 15 years of age, due to their embryonic origin. It is also aimed to describe their aspect on MRI and evaluate the interobserver agreement in the detection of Rathke's Cleft Cyst.

Rathke's cleft cysts (RCC) are benign cystic lesions in the sellar region and correspond to embryonic remnants of the Rathke's pouch. The prevalence of RCC in the literature is higher in adults than in children, but the data for children is limited and outdated. The hypothesis is that the frequency of RCC has been underestimated in children and that it actually decreases with age, especially in adults. The main objective of this descriptive study is to study the prevalence and signal of RCC in children under 15 years of age.

460 encephalic MRIs of children under 15 years of age comprising at least one sagittal sequence without T1-weighted injection and/or a T2 sagittal sequence adapted to the study of the pituitary gland, were analyzed retrospectively. Examination analyses was performed blindly by two radiologists for serous RCC, hypersignal on T2-weighted and isosignal T1-weighted sequences, and mucosal RCC, hyposignal on T2-weighted sequences and hyper or isosignal on T1-weighted sequences. The results were consensually read in case of disagreement on the presence or absence of an RCC.

Of the 460 patients included, the prevalence of RCC was 3% (14/460). 21% of the RCC cases (3/14) were serous and 79% (11/14) were mucosal. Of the 14 patients with RCC, a post-pituitary cyst was also found. The interobserver agreement was strong with a Cohen kappa coefficient of 0.85.

The prevalence of RCC in children under 15 years of age (3%) is higher than that described in the literature (1.2%) and is close to that of adults (3.9%). RCCs are thus intra-sellar lesions of relatively frequent discovery in children, i.e. to identify in order to not erroneously lead to a differential diagnosis including tumors which would lead to a different prognosis, management, and follow-up.

Eligibility Criteria:
Inclusion Criteria:

* children aged 15 or under at the time that an MRI was performed exploring the sellar region
* MRI with at least T1 spin echo (SE) sagittal slices with a slice thickness of 2.5 or 3 mm with inter-slice spacing of 0.3 mm and T2 SE with a slice thickness of 2 mm and inter-slice spacing of 0.2 mm.

Exclusion Criteria:

* Patients with incomplete MRI protocol
* Patients whose MRI images had artifacts (patient movement, presence of dental material)
* Patients with suspected pituitary pathology due to endocrine symptomatology (growth retardation, puberty delay, diabetes insipidus) that could be attributed to an intrasellar injury were also excluded.
Hemodynamic Effects of Physiotherapy in the Early Postoperative Period

Physiotherapy will be applied to the patients who undergo thoracotomy operation after 24 hours of intensive care stay. Physiotherapy program includes breathing exercises, incentive spirometer training, ambulation. Oxygen saturation, heart rate and blood pressure values will be recorded before and after the training session. Changes in the follow-up parameters will be discussed.


Eligibility Criteria:
Inclusion Criteria

* Between 18-75 age
* Hemodynamically stable
* Being conscious

Exclusion Criteria:

* Excessive pain
* Neurological complications
* Posttraumatic and musculoskeletal problems to prevent exercise
* Do not want to be included in the study
* Fever above 38 degrees
Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock

To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.

Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.

Objective To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.

Methods A prospective observational study was carried out. The eligible patients were treated with the standard procedure of EGDT. The hemodynamic data were recorded. Oxygen metabolism and hepatic function were monitored. Indocyanine clearance test was applied to detect the hepatic perfusion. Hemodynamics, hepatic perfusion, oxygen metabolism and hepatic function were compared before treatment, after EGDT and 24 hours after EGDT.

Eligibility Criteria:
Inclusion Criteria:

1. patients with septic shock
2. at least one of the EGDT criteria not achieved
3. informed consent accepted

Exclusion Criteria:

1. ages below 18 or above 90
2. pregnancy
3. the time elapsed over 24 hours after onset of septic shock
4. chronic liver disease
5. terminal stage of disease
6. brain death
7. other types of shock
8. brain injury
9. allergic to iodine or indocyanine
Prostate Interstitial Brachytherapy With I125 Implant With Target Dose Supplementation in the Tumor Volume Guided by TRINITY® PERINE 3D System

The objective of the FOCUS-Boost project is to implant for the first time with a 3D ultrasound image fusion registration system (3D echo) implant of iodine 125 with precision in a target volume determined by positive biopsies.

The interstitial brachytherapy procedure for the prostate does not allow for a robust focal treatment to accurately deliver additional dose to the tumour volume. FOCUS BOOST allows the precise implantation of 125 iodine implant with greater accuracy (using a 3D ultrasound image fusion registration system) in a target volume.

For this purpose, positive biopsies, performed in this research protocol, will be used prior to surgery. Prostate brachytherapy will be optimised thanks to the TRINITY® system and its guidance quality, by increasing the dose of the intra-prostate tumour volume (BOOST) without increasing the total dose delivered to the prostate. Increasing the dose to the tumour target volume could improve disease control and decrease the risk of recurrence.

Eligibility Criteria:
Inclusion Criteria:

* At least 18 years
* Patient to be treated with brachytherapy
* Patient with low or favorable intermediate risk prostate adenocarcinoma ISUP 1 and 2, G6 (3+3) or G7 (3+4)
* Life expectancy of more than 10 years
* PSA (prostate-specific antigen) \< 15 ng/ml
* cT1c or cT2a or cT2b
* Prostate volume ≤ 60 cc
* ECOG Performance status 0-2
* Patient is affiliated to a health insurance system
* Patient who has signed consent form

Exclusion Criteria:

* Patient with urinary function disorders IPSS\> 14
* Prostate volume \> 60cc.
* Gleason 7(4+3) or Gleason score ≥8
* PSA ≥ 15 ng/ml
* Patient with metastases
* Hormone therapy with antiandrogen or LHRH analogue
* History of abdominopelvic irradiation
* Inflammatory digestive disease (haemorrhagic rectocolitis, Crohn's disease)
* Interventional study in progress that may interfere with the present study
* Protected persons (patient concerned by articles L1121-5, L1121-6, L1121-8 of the French public health code)
Prevalence of Knowledge, Attitudes and Perception of Covid Vaccine in Iraq. A Cross Sectional Study

Numerous scientific agencies and iraqi MOH has advised to promote population vaccination as an attempt to reduce the burden of COVID19. The aim of our study is to evaluate knowledge, Attitude, practice and concerns toward different type of covid19 vaccine of Iraqi population. This will help us concentrate our efforts to increase Willingness of vaccination among southren Iraqi people

Detailed Description: New human pandemic disease that have large of world population concern and have many challenges that effect on their life directly or indirectly is coronavirus infection (COVID 19).Numerous scientific agencies and iraqi MOH has advised to promote population vaccination as an attempt to reduce the burden of COVID19 so need to evalute knowledge, Attitude, practice and concerns toward different type of covid19 vaccine of iraqi population to increase willing of vaccination among southren Iraqi population to reduce mortality rate of covid19 and searching for incidence vaccination against it. So to decrease complication of covid19 pandemic, they introduced covid19 vaccine that has essential role to maintain our life. So many companies of manufacturing of covid19 vaccine with different ways by using part of viruses spike of protein or whole virus after attenuated but some Iraqi population hesitancy that delay of acceptance in spite of this vaccination is represent one of method to protect themselves from infected with covid19 in addition attended social event ,shaking hands ,leaving place when talking with other person and still wearing of mask.

Important recognition key for prevention and maintain our life is attitude judgment and how to do this to give positive or negative idea about covid19vaccine according to different source of information that concerning like social media ,experience of previous personal , governmental information and health care professional sources Considering lake of studies and research related to covid19 vaccine in Iraq ,so there is urgent need to know refused or hesitant attitude in southern Iraqi population

Eligibility Criteria:
Inclusion Criteria:

* Willingness to participate in the study
* Living in southern Iraq

Exclusion Criteria:

* Less than18 years
* Not willing to complete the questionnaire
* Unable to complete the questionnaire
MARS MRI in Revision THA With a Ceramic Femoral Head and Titanium Sleeve

Revision total hip replacement using a ceramic head utilizes a titanium sleeve which introduced another articulation into the system that may lead to a local soft tissue reaction. The purpose of this study is to determine the frequency, size and types of MRI documented local tissue reactions in individuals doing well after a revision total hip replacement and ceramic bearing surface that utilizes a titanium sleeve.

Metal-on-metal total hip arthroplasty (THA) were heralded as a solution for two of the most common problems in hip arthroplasty in the last decade, instability and osteolysis. Unfortunately, their failures have led to diminished enthusiasm for this bearing surface. Adverse local tissue reactions (ATLRs) have been well documented as a means of pain and failure in this population. A recent report revealed that the most commonly used bearing surface in total hip arthroplasty, metal-on-polyethylene, may have up to a 28% incidence of MRI abnormalities in asymptomatic hips. Revision THA using a ceramic head utilizes a titanium sleeve which introduced another articulation into the system that may lead to a local soft tissue reaction. The purpose of this study is to determine the frequency, size and types of MRI documented local tissue reactions in asymptomatic individuals after a revision THA and ceramic bearing surface that utilizes a titanium sleeve. To our knowledge, this has not been studied previously and may provide important baseline features of this diagnostic tool with this particular bearing surface. We hypothesize that there will be fluid collections in a small but clinically significant portion of asymptomatic patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients who received a revision total hip surgery utilizing a ceramic femoral head with a titanium sleeve
* Patient whose age ranges from 18-99
* Patients who are not experiencing groin pain, thigh pain, or pain with ROM of the hip
* Patients who are at least 2 years after a revision THA
* Acetabular implant (cup) was placed in the appropriate position
* Patients with a Harris Hip Score of \>90

Exclusion Criteria:

* Patients who do not meet the above criteria
* Patients unable to have an MRI (i.e. pacemaker, metal implants or issues with claustrophobia requiring sedation)
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery

Patients presenting for normal spontaneous vaginal delivery who have a neuraxial anesthestic will be randomized to receive preservative free morphine or saline placebo after delivery.

After obtaining consent, women presenting to the labor floor at Mount Sinai Hospital will be randomized into two groups, intervention and placebo. Baseline demographic data and surveys in regards to postpartum depression, anxiety, breastfeed willingness and pain scores will be obtained. After delivery of the baby patients will either receive 2mg preservative free morphine or saline via the epidural catheter prior to its removal. The study team will then record pain and recovery scores, as well as follow up screens to the aforementioned endpoints. The study will end at the 6 week postpartum visit with the patient's obstetrician.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women in labor

Exclusion Criteria:

* Not a candidate for neuraxial anesthesia
* Patient refusal
* Allergy to morphine
* Patients with chronic pain syndromes
Effects of Attentional Focus Strategy on Dual-task Walking Training in Patients With Parkinson's Disease

Walking deficits and altered brain capacity have been proved to be two of the main contributing factors in dual-task walking deficits in patients with Parkinson's disease (PD). In the past, patients with PD were usually suggested not to walk in dual-task conditions in order to concentrate on their walking performance better. However, since dual-task walking is really common in daily-life, this limitation usually lead to a decrease in quality of life for PD patients. In previous studies, effects of using attentional strategies in dual-task walking training remain unclear, while suitable attentional strategies and corresponded neuroplasticity for patients with and without freezing of gait have not been well discussed, either. Accordingly, this study is aimed to identify (1) whether internal or external attentional strategies is more ideal for PD patients with and without freezing of gait in dual-task walking training, and (2) changes in brain activity after receiving dual-task walking training with different attentional strategies in patients with or without freezing of gait. Our hypothesis are (1) patients with or without freezing of gait will react differently in dual-gait training with different attentional strategies, and (2) changes in brain activities will be different according to different attentional strategies given in the training.

The hypothesis will be tested by gait performance, suprapostural tasks performance, relative power spectrum of EEG, and scales including MDS-UPDRS, ABC, BBS, and TUG.

Eligibility Criteria:
Inclusion Criteria:

for PD patients:

* (1) a diagnosis of idiopathic PD by a neurologist expert in movement disorders (2) onset age \> 40 years old, (3) presence of gait disorders or freezing of gait (points on 3.10 in MDS-UPDRS\>=1 or points on item 3 in NFOG-Q \>0) (4) able to walk independently without an assistance device at least for 20 meters (5) without obvious action or postural tremor, according to the score of 3.15 and 3.16 (action and postural tremor of hands) in MDS-UPDRS

for healthy elders:

* (1) without musculoskeletal of neurological diseases which may affect balance or walking performance (2) no medication that might influence their balance or cognition (3) MMSE\> 26 points.

Exclusion Criteria:

for PD patients:

* (1) with other neurological or musculoskeletal disease that might affect balance or walking (2) have a Mini-Mental State Examination (MMSE) \< 27 points (3) have a history of brain surgery (4) have to modulate their medication for duration of the experiment.
Impacted Canine and Mixed-reality Technology - RCT

The goal of this clinical trial is to determine whether the use of HoloLens 2 mixed reality goggles for planning alignment of palatally impacted canine reduces: 1) treatment time and 2) the risk of complications compared to planning alignment of palatally impacted canine without HoloLens 2 goggles.

Participants will have an impacted canine on palatal side.

Researchers will use or will not use HoloLens 2 goggles in planning therapy

Participants will wear fixed orthodontic appliances for the treatment of impacted canine. During treatment, attachment will fixed to an impacted canine and the direction of traction will be established.


Eligibility Criteria:
Inclusion Criteria:

* Healthy boys/men and girls/women aged between 10 and 20 years.
* Palatally impacted canine on one side
* Axis of the canine \> 10 degrees to the midline as measured on a pantomographic radiograph
* During orthodontic treatment, in preparation for alignment of the impacted canine with adequate space for the retained canine

Exclusion Criteria:

* Dental abnormalities (hyperodontia, hypodontia, etc.)
* Impacted canines bilaterally
* Previous trauma to the teeth or face
* Congenital craniofacial malformations
* Systemic diseases that would hinder orthodontic treatment/operation
* Recent radiotherapy
HER2 Circulating Tumor Cells in Gastric Cancer

The investigators propose to survey the frequency of HER2 (+) CTC in order to lay groundwork for future clinical trials incorporating Her-2 targeted agents in gastric cancer.

We propose to survey the frequency of HER2 (+) CTC in order to lay groundwork for future clinical trials incorporating Her-2 targeted agents in gastric cancer. Blood samples will be collected from metastatic gastric cancer patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients older than 18 years ② Patients with localized, histologically confirmed gastric cancer ③ Informed consent form

Exclusion Criteria:

* No informed consent form
An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan

Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Participants with UC have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon. This study will assess how safe and effective Rinvoq is in treating adult participants with moderate to severe ulcerative colitis (UC). Adverse events and change in disease activity will be assessed.

Rinvoq is a drug approved for the treatment of ulcerative colitis (UC). All study participants will receive Rinvoq as prescribed by their study doctor in accordance with approved local label. Approximately 300 adult participants will be enrolled in Japan.

Participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed for up to 60 weeks.

There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.


Eligibility Criteria:
Inclusion Criteria:

* Participants diagnosed with moderately to severely active Ulcerative colitis (UC).
* Participants who are within 14 days from the commencement of Rinvoq treatment for UC.
* Participants who are administered the first dose of Rinvoq for UC after approval for UC in Japan.

Exclusion Criteria:

* Participants currently participating in registrational clinical trial.
* Participants for whom Rinvoq is contraindicated.
* Participants that have been previously exposed to Rinvoq.
Pathophysiology and Treatment of Cerebrospinal Hypotension Exploration Study

The goal of this observational study is to learn about the effects of a low-pressure environment on the brain in patients with intracranial hypotension and to potentially improve diagnostics and treatment of this condition.

The primary objective will be:

To investigate the change in clinical biomarkers measured before and after successful treatment.

The secondary objectives will be:

To investigate if clinical biomarkers can predict the outcome of treatment. Participants undergoing standard treatment for intracranial hypotension will undergo additional examinations and surveys and will be followed up for a year for the study.


Eligibility Criteria:
Inclusion Criteria (patients):

* Age 18-80.
* Patients with a suspected intracranial hypotension diagnosis.
* Participants must read and understand the Danish language or have an official interpreter present to be able to understand the work-up and sign the participation consent for the study.

Inclusion Criteria (Control):

* Age 18-80.
* Healthy people who do not suffer from any form of primary headache except infrequent tension-type headache.
* Participants must read and understand the Danish language or have an official interpreter present to be able to sign the participation consent for the study.

Exclusion Criteria (patients):

* Pregnant or breastfeeding females
* Patients in whom the examination cannot be performed due to anatomical reasons such as severe head dysmorphia or severe ophthalmological diseases.
* The patient has a disease, takes medication, or abuses alcohol or drugs that could, in the investigator´s opinion interfere with the assessments of safety, tolerability, or efficacy, or interfere with the conduct or interpretation of the study.
* The patient is, in the investigator´s opinion, unlikely to comply with the protocol or is unsuitable for any reason.

Exclusion Criteria (Control):

* Pregnant or breastfeeding females
* Participants in whom the examination cannot be performed due to anatomical reasons such as severe head dysmorphia or severe ophthalmological diseases.
* The participant has a disease, takes medication, or abuses alcohol or drugs that could, in the investigator´s opinion interfere with the interpretation of the study.