cyrilzakka/clinical-trials huggingface dataset:
Effects of Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Acute Ischemic Stroke

The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.

Current studies have shown that repetitive transcranial magnetic stimulation can change the excitability of nerve cells, improve intracerebral artery blood supply, and even reduce the degree of neurological impairment in patients with ischemic stroke. The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥ 18 years, both sexes;
2. Clinically definite diagnosis of acute ischemic stroke;
3. Baseline National Institute of Health Stroke Scale (NIHSS) score ≤25;
4. Pre-onset modified Rankin Scale (mRS) score ≤1;
5. Randomized and initiated transcranial magnetic stimulation within 1 week of onset;
6. Subject or legal representative agreed to the treatment and signed the informed consent.

Exclusion Criteria:

1. Presence of a medical condition such as severe cognitive impairment or mental impairment;
2. Patients with serious physical diseases or who have had craniocerebral surgery;
3. Previous history of epilepsy, family history of epilepsy or presence of seizure provoking factors;
4. Pregnancy or breastfeeding;
5. The presence of metal foreign bodies near the stimulation site, such as intracranial metal implants, cochlear implants, built-in pulse generators (brain pacemakers, cardiac pacemakers), etc.;
6. Patients who are unable to complete cerebral autoregulation, or bilateral temporal window penetration poorly;
7. life expectancy of ≤3 months or inability to complete the study for other reasons;
8. unwillingness to be followed up or poor treatment compliance;
9. Those who are participating in other clinical investigators, or who have participated in other clinical studies within 3 months prior to enrollment, or who have participated in this study;
10. Other conditions that the investigators deemed unsuitable for enrollment.
Attention Training Technique and Mindful Self-Compassion

The design of the study is a randomized controlled trial. A total of 80 students with self-reported symptoms of stress/anxiety/depression will be invited to take part in a 3-session course consisting of either attention training or self-compassion/mindfulness based meditation. Attention training involves modifying metacognitive control and enhancing attention flexibility so that people can refrain from responding to intrusions with extended processing. Self-compassion involves not avoiding painful or distressing feelings. Instead these experiences are held in awareness with kindness, understanding, and a sense of shared humanity.


Eligibility Criteria:
Inclusion Criteria:

* self reported symptoms of stress/anxiety/depression

Exclusion Criteria:

-
AZD9773 Dose Escalation Study

This is a double-blind, placebo-controlled, multi-center, dose-escalation study to assess the safety, tolerability, Pharmacokinetics and Pharmacodynamics of single and multiple ascending intravenous infusions of CytoFab (AZD9773) in adult patients with severe sepsis.


Eligibility Criteria:
Inclusion Criteria:

* Clinical evidence of infection requiring treatment with parenteral antibiotics
* Patients must meet multiple Systemic Inflammatory Response Syndrome (SIRS) criteria
* Patients must meet criteria for cardiovascular and/or respiratory dysfunction
* Sepsis (infection plus SIRS criteria) must be present prior to organ dysfunction

Exclusion Criteria:

* Moribund and death is considered imminent, or patient not expected to survive 90 days because of underlying medical condition, or classified as Do Not Resuscitate or Do Not Treat
* Patient cannot attain a MAP \>60 mmHg when measured via an arterial line and/or a Systolic Blood Pressure (SBP) \>80 mmHg in the presence of vasopressors and iv fluids for a period of ≥2 hours
* Receiving immunosuppressants, or high dose steroids within 2 months of provision of informed consent
* Any history of hypersensitivity reaction to sheep products, latex, papain or papaya, or chymopapain or previously administered antivenom manufactured using ovine serum, digoxin immune fab (DigiFab™ , DIGIBIND® ), crotalidae polyvalent immune fab (ovine) (CroFab™ ), or other sheep derived product.
* Treatment with anti Tumor-Necrosis-Factor (anti-TNF) antibodies within 8 weeks before provision of written informed consent.
Evaluation of Different Modelling Techniques on Child Anxiety (RCT)

A huge number of children suffer from anxiety during their dental treatment especially those who did not receive any type of behavior management during their first dental visit. This will result in a more complicated treatment sessions for the children, dentist and the parents. Fear and anxiety control is the key to change the resistant nature of the anxious patients and also allow them to receive the proper treatment they require. From the point of view that there is no difference between the techniques effectiveness, evaluation of two modelling techniques (live modelling and filmed modelling versus no modelling) for children anxious behavior management during the dental treatment will be performed.

i. Diagnosis:

1. History taking \[personal, medical and dental\].
2. Clinical examination using mirror and probe.
3. Radiographic examination to make sure that the caries is simple.
4. Preoperative photograph is taken.

ii. Interventions to each group

1. Group A: Live modelling technique

   1. In the 1st dental visit the operator will start by measuring the behavior of the child by Frankl behavior rating scale.
   2. A cooperative patient will be the model for the child.
   3. In the 2nd dental visit the pulse oximetry device will be installed on the child's finger and another form of Frankl behavior rating scale is filled.
   4. The treatment is performed as follows:

   i. Place topical anesthesia. ii. Place anesthetic injection. iii. Cavity preparation. iv. Filling material placement. v. Finishing of the filling. e. The child will be asked to complete a facial image scale
2. Group B: video modelling technique (1) In the 1st dental visit the operator will start by measuring the behavior of the child by Frankl behavior rating scale.

   1. A recorded film will be shown to the child.
   2. In the 2nd dental visit the pulse oximetry device will be installed on the child's finger and another form of Frankl behavior rating scale is filled.
   3. The treatment is performed as follows:

   i. Place topical anesthesia. ii. Place anesthetic injection. iii. Cavity preparation. iv. Filling material placement. v. Finishing of the filling. d. The child will be asked to complete a facial image scale.
3. Group C: No modelling

   1. In the 1st dental visit the operator will start by measuring the behavior of the child by Frankl behavior rating scale.
   2. In the 2nd dental visit the pulse oximetry device will be installed on the child's finger and another form to Frankl behavior rating scale.
   3. The treatment is performed as follows:

   i. Place topical anesthesia. ii. Place anesthetic injection. iii. Cavity preparation. iv. Filling material places. v. Finishing of the filling. d. The child will be asked to complete a facial image scale.

Eligibility Criteria:
Inclusion Criteria:

1. English articles
2. In vivo study (RCT)
3. Medically free children
4. Age group 5-6 years old

Exclusion Criteria:

1. Medically compromised children
2. Adult patients
Vaginal Infection Study

This study will evaluate the efficacy and safety of a vaginal product compared with that of other vaginal products in the treatment of vaginal infections.


Eligibility Criteria:
Inclusion Criteria:

* Patients must have a clinical diagnosis of vaginal infection.
* Patients must be post-menopausal, surgically sterilized or using an acceptable form of birth control.

Exclusion Criteria:

* Patients must not have any other infections
* May not be pregnant or nursing
* May not be receiving any other antimicrobial therapies or any medications that would interfere with the outcome of the study.
Physician-Patient Communication About Breast Cancer-Related Internet Information and Its Effect on Patient Satisfaction and Anxiety

The purpose of this study is to learn about how patients who have looked up cancer-related information on the internet talk with their doctors. We are interested in these conversations even if the patients do not think they will talk about the information with their doctor during their visit. We will audio record doctor-patient visits and listen to these recordings to learn about how patients who have looked up cancer-related internet information talk to their doctors and how their doctors talk to them. We will also give patients questionnaires before and after their appointments to learn about what they think about communicating with their doctors.


Eligibility Criteria:
Inclusion Criteria:

Subject Inclusion Criteria for Patients

* Female
* Diagnosis of breast cancer
* Pre-surgery (\*for breast surgeon patients only)
* Report that they have read breast cancer-related internet information since their diagnosis with breast cancer.
* Provide informed consent

Subject Inclusion Criteria Physicians

* Breast surgeon or breast medical oncologist
* Agree to participate in study and one of 10 selected participants
* Provide inform consent

Exclusion Criteria:

Exclusion Criteria for Patients

* Less than 21 years of age
* Cognitive or physical impairment rendering patients incapable of providing informed consent to participate in the study
* As the measures and coding system are all written in English, subjects who are not fluent in English will be excluded.

Exclusion Criteria for Physicians

* None
Postoperative Analgesia in Patients With Microvascular Decompression

Perioperative pain is caused by a variety of harmful factors through multiple mechanisms, therefore, reasonable postoperative analgesia should be combined with drugs or measures of different mechanism , which is called multimodal analgesia. Multimodal analgesia could minimize side effects and achieve a better analgesic effect. Commonly used strategies of multimodal analgesia are oral analgesic drug, nerve block, patient controlled analgesia and so on. This study will observe the effect of multimodal analgesia on postoperative pain in patients with microvascular decompression and record side effects. Finally, it will provide technical support for the guidance of postoperative analgesia in patients of trigeminal neuralgia.

The investigators will collect 90 cases which will be divided into 3 groups. Patients in Group A will receive scalp nerve block and patient-controlled analgesia which contains sufentanil and ondansetron. In Group B, patient-controlled analgesia which contains sufentanil, ondansetron and ketamine will be applied. In Group C, patient-controlled analgesia which contains sufentanil and ondansetron will be applied.

Eligibility Criteria:
Inclusion Criteria:

1. Patients of trigeminal neuralgia plan to receive microvascular decompression
2. Age between 18 and 70, ASA classification between Ⅰ～Ⅲ
3. No severe liver and kidney disease, no blood coagulation dysfunction
4. No history of long-term opioid drugs usage, no drug addiction history
5. Patients are fully conscious, cooperation, understanding and voluntarily signed informed consent

Exclusion Criteria:

1. More than 20% of the total blood volume is lost in operation
2. Intracranial hematoma happens within 24 h after surgery
3. Secondary surgery patients
Pharmacokinetics and Safety of Fevipiprant in Patients With Renal Impairment Compared to Matched Healthy Subjects

The aim of the study is to assess whether renal impairment could affect fevipiprant pharmacokinetics (PK) to the extent that dosage adjustment is appropriate for this patient population.

The study also aims to determine the effect of dialysis on the fevipiprant pharmacokinetic profile as the procedure might remove a significant fraction of the drug.

The purpose of this study is to determine if the pharmacokinetic profile of fevipiprant is different in patients with renal impariment compared to healthy matched volunteers to an extent that would require an adjustment of the dosage. Data from this study will be used to guide enrollment criteria in future clinical trials and to support regulatory submission and labeling information

Eligibility Criteria:
Inclusion Criteria:

* Healthy subjects must satisfy the criteria for normal renal function as evidenced by normal Glomerular Filtration Rate (GFR): eGFR ≥ 90 mL/min/1.73m2; each healthy subject must match in age (+/- 10years), gender, smoking status, and weight (+/- 15%), a patient from the renail impaired patient groups:
* A body mass index (BMI) within the range of 18 - 36 kg/m2
* ESRD patients on hemodialysis: an glomerulo filtration rat GFR of \< 15 mL/min/1.73 m2
* patients with severe renal impairment: GFR of\< 30 mL/min/1.73m2 (without need of hemodialysis);
* patients with moderate renal impairment: 30 mL/min/1.73m2 ≤ eGFR \< 60 mL/min/1.73m2;
* patients with mild impairment: 60 mL/min/1.73m2 ≤ eGFR \< 90 mL/min/1.73m2

Exclusion Criteria:

* Pregnant or nursing (lactating) women
* History or evidence of any inherited bilirubin disease or disorder
* subjects participating in another study
* malignancies in the past
* Hemoglobin levels below 10 g/dL at screening
* HIV positiv
* Heavy smokers (≥20 cigarettes per day)
* Liver disease, as indicated by ALT, γ-GT, AST and alkaline phosphatase which should not exceed twice the upper limit of normal and should be stable (e.g. increased liver values known from previous patient records). Serum bilirubin \> 27 μmol/L (1.6 mg/dL)
* Clinically significant ECG changes and/or arrhythmias
* Chronic infection with Hepatitis B (HBV) or Hepatitis C (HCV)
Virtual Neuroprosthesis: Restoring a Sense of Touch to Amputees

The overall goal of this project is to develop a virtual neuroprosthesis in which a facsimile of a neural implant is externalized and housed in a well-controlled microfluidic chamber, thereby abating the intrinsic limitations of highly invasive studies with neural implants. Able-bodied and upper limb amputee subjects will be recruited to control a dexterous artificial hand and arm with electromyogram signals while electroencephalogram (EEG) signals are simultaneously measured. Robotic grip force measurements will be biomimetically converted into electrical pulses similar to those found in the peripheral nervous system to catalyze in vitro nerve regeneration after neurotrauma. The synergistic contributions of this multidisciplinary project will lead to a transformative understanding of the symbiotic interaction of neural plasticity within human-robotic systems. Currently, there is no systematic understanding of how tactile feedback signals can contribute to the neural regeneration of afferent neural pathways to restore somatosensation and improve motor function in amputees fitted with neuroprosthetic limbs. Tackling this problem will be a significant breakthrough for the important field of neuroprosthetics.

Over one week, neurobehavioral processes will be examined in people controlling a robotic arm and hand to perform simple motor tasks (e.g. fragile object transportation), while a virtual peripheral nerve regeneration protocol provides users with biologically-realistic, idiosyncratic parameters for the restoration of haptic sensation (in double-blind fashion, the cellular neurophysiologists characterizing neural regeneration with microscopy are unaware of subjects' name and condition; and the human-subject experimenters are unaware of the haptic feedback parameter that will be used in the experiment each day, which is entered by the neurophysiologist in a black-box section of the software in the case of microscopic evaluation of nerve regeneration (early part of the project), or which is automatically input by the system in the case of real time impedimetric measurements (later part of the project)).

The main experimental factors are 'haptic feedback', with three modalities: full, partial (nerve-regeneration dependent) and null; and to challenge human control strategy and impose demand on haptic information, the 'transported object weight' (heavy, medium and lightweight).

Recording techniques: Subjects' electroencephalography (EEG), electromyography (EMG) and behavioral performance.

Eligibility Criteria:
Inclusion Criteria:

* No neurological impairment of tactile sensation.

Exclusion Criteria:

* Younger than 18 or older than 65
Evaluation of the Efficiency of the Technology-Based Psychosocial Empowerment Program Program

This research was planned to evaluate the effectiveness of the technology-based psychosocial empowerment program for home care for children aged 8-18 years with cancer and their parents as a parallel-group randomized controlled study design.The required institutional permission and ethics committee approval was received.The study group of the study consisted of 72 children and parents (intervention group \[n=36\], control group \[n=36\]). Data were collected using the descriptive features form, the General Self-Efficacy Scale-Pediatric Cancer Version, the State and Trait Anxiety Inventory for Children, the Pediatric Cancer Coping Scale, the General Self-Efficacy Scale for parents, the Problem-Solving Scale, and the Cope and Adaptatıon Process Scale. The data were stored in the SPSS 25 program.

The incidence of childhood cancers has become an important health problem increasing all over the world. Children and parents are affected in many dimensions physically, psychologically, and socially during this experience. The needs of the child and parents are not limited to the treatment period in the hospital. They also need to be supported and strengthened during the home care process. The required institutional permission and ethics committee approval was received. The study group of study consisted of 72 children and parents (intervention group \[n=36\], control group \[n=36\]).The technology-based program was applied to children and families for 4-6 weeks through modules on the website. In addition, at the end of each module, online interviews or telephone counseling will be applied.Children and parents in the control group will follow the standard care procedures included in the treatment process. At the end of the study, it was planned to apply website modules to the children and parents in the control group. The research is based on the Psychological Empowerment Theory.

Eligibility Criteria:
Inclusion Criteria:

* For children's:

Children between the ages of 8-18, Those receiving cancer treatment (leukemias and solid tumors) and completing the first 2 months of the treatment process, Children with tablets, android phones and internet access Children whose parents and themselves agree to participate in the study, Children who can continue the study for 4-6 weeks,

For primary care parents, Parents who can speak Turkish, Parents who can use computers and android mobile phones, Parents who agreed to participate in the study, Parents who can continue the study for 4-6 weeks,

Exclusion Criteria:

* Newly diagnosed children (in induction phase), Children who are in the terminal period or who are treated for relapse, Presence of another important disease (such as chronic disease, psychiatric diagnosis) in the family that may prevent coping, other than the child followed up with the diagnosis of cancer
A Direct-to-patient Intervention to Increase Rates of Osteoporosis Care

The purpose of this study is to conduct a randomized trial of a tailored intervention designed to provide personalized feedback regarding patients' risk of subsequent fractures, customized information regarding osteoporosis care, and messaging to activate patients to become more engaged in improving osteoporosis treatment and doctor-patient communication. This novel content will use "story-telling" delivered via the Internet and digital video discs (DVDs). The content will be uniquely tailored to each person based on barriers to care, age and race/ethnicity. We will conduct a controlled, cluster-randomized trial of this intervention to determine differences in post-intervention rates of osteoporosis care between two randomization arms.

We hypothesize that participants randomized to the intervention arm, compared to those randomized to a control arm, will receive more osteoporosis care at 6 months post-intervention, as evidenced by higher rates of: (H1) Prescription osteoporosis therapies, (H2) Non-prescription therapy with calcium and vitamin D, and (H3) Bone mineral density (BMD) testing.


Eligibility Criteria:
Inclusion Criteria:

* Self-reported history of fracture

Exclusion Criteria:

* Self-reported current prescription osteoporosis treatment
Effects of Lumbopelvic Manipulation on Hip and Knee Neuromuscular Activity

The purpose of this study is to determined if a lower back treatment would change the hip and knee muscle activities in people with and without anterior knee pain. The investigators hypothesized that the lower back treatment may change the hip and knee muscle activities in people with anterior knee pain but not in people without anterior knee pain.


Eligibility Criteria:
Inclusion Criteria for participants in the patellofemoral pain syndrome group:

1. insidious onset of symptoms of non-traumatic origin
2. pain with patellar facet palpation or compression
3. subjective knee pain rating of at least 3/10 on the pain visual analog scale during at least one of the following activities:

   * ascending stair
   * descending stair
   * kneeling
   * squatting
   * running
   * jumping
   * prolong sitting for more than 20 minutes

Exclusion criteria for all participants:

1. history of spine, hip or knee surgery
2. history of hip pathology or other knee condition
3. current significant injury of any lower extremity joints
4. pregnancy
5. sign of nerve root compression
6. osteoporosis or history of compression fracture

Age- and gender- matched control participants will be recruited if they have no signs or symptoms of patellofemoral pain syndrome and have none of the exclusion criteria
Common Allergens in Skin Tests for Adult Atopic Dermatitis

To analyze the common allergens revealed by skin tests in adult atopic dermatitis patients.

The allergens involved in atopic patients are widely existed in our environment. Traditionally, we use serum specific IgE, skin prick test or intradermal test to verify the possible causative allergens in patients with atopic dermatitis. This study will evaluate the correlation between serum specific IgE, skin prick test, intradermal test, and patch test for common allergens in adult patients with atopic dermatitis.

Eligibility Criteria:
Inclusion Criteria:

* patients with atopic dermatitis (according to Hanifin and Rajka criteria)
* age older than 16 years old

Exclusion Criteria:

* pregnancy