cyrilzakka/clinical-trials huggingface dataset:
Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais

The purpose of this study is to study the efficacy of allergen injection immunotherapy for allergic rhinitis by

* symptoms score
* medication score
* quality of life
* immunologic test from blood

Compare the efficacy of allergen injection immunotherapy between the treatment group and the placebo group after injection for

* 2 months
* 6 months
* 12 months

Eligibility Criteria:
Inclusion Criteria:

* patients with the symptoms of allergic rhinitis who sensitized to mite (Dermatophagoides pteronyssinus)
* positive skin prick test to D.p. at 4+ degree

Exclusion Criteria:

* steroid dependent asthma
* force expiratory volume (FEV1) less than 70% of predicted value
* previous injection immunotherapy within 2 years
* pregnancy
* medical conditions such as ischemic heart disease, autoimmune disease, cancer, previous history of anaphylaxis
Time to Accurate Heart Rate on Neonatal Outcomes

The goal of this trial is to compare the time to first heart rate displayed for iRes Warmer with ResusView and using iRes Warmer without ResusView when used in the resuscitation (e.g. Cardiopulmonary resuscitation or breathing assistance) of premature newborns (23 to 32+6 weeks gestation).

This is a prospective interventional randomized control trial. Infants born between 23+0 and 32+6 estimated gestational age will be randomized using a computer generate allocation sequence stratified by gestational age. Randomization cards will be placed in opaque envelopes. For the intervention group, the care team will use the Panda iRes Warmer with ResusView Bed during resuscitation interventions in the first 10 minutes of life. During use of the iRes-warmer, standard nursing care of an infant on a radiant warmer will be followed. Participants assigned to the control group will receive interventions using the same model Panda bed without ResusView. There is no minimum time for monitoring, and the maximum time depends on clinical determination for use of heart rate feature for each resuscitation event. Data including the infant's gestational age, Electrocardiogram lead type and activities that occurred during resuscitation will be recorded for the first 10 minutes of life.

Eligibility Criteria:
Inclusion Criteria:

* Infants who are delivered to mothers over the age of 16 years of age
* Infants delivered at 23+0 to 32+6 weeks estimated gestational age based on the best obstetric estimate at the time of delivery.
* Infants without known congenital malformations prior to delivery
* Antenatal consent

Exclusion Criteria:

* Infants who are delivered to mothers under the age of 16 years of age
* Known congenital anomalies of newborn prior to delivery
* Cardiac defects other than small Ventricular septum defect and Patent ductus arteriosus
* Multiples
* Declined consent
* iRes Warmer with ResusView not available at time of delivery
Treatment Protocol of Replagal for Patients With Fabry Disease

The study will evaluate the safety and efficacy of Replagal® (agalsidase alfa) at a dose of 0.2 mg/kg infused intravenously (IV) over 40 minutes, every other week. The study will monitor the course of disease in males and females with Fabry disease who are naive to treatment or were previously treated with agalsidase beta (Fabrazyme®).

This study will evaluate the safety and efficacy of Replagal in patients with Fabry disease who are either naive to treatment, who were previously treated with agalsidase beta, or who had previously received Replagal.

Patients diagnosed with Fabry disease who have not previously received treatment, who have received agalsidase beta, or who had previously received Replagal will be eligible to enroll in the study and will receive Replagal at a dose of 0.2 mg/kg body weight administered by an IV infusion over 40 minutes every other week.

This study will be conducted in the United States.

Study visits will occur in 3 phases:

* Screening/Baseline Phase: A Screening/Baseline period (Day -30 to Day -1) to determine eligibility and obtain baseline measurements. Patients who have previously received agalsidase beta will be tested for the presence of anti-agalsidase beta antibodies.
* Treatment Phase: A 12-month treatment phase during which all patients will receive Replagal administered IV every other week. Clinical assessments will occur at Months 1, 3, 6, 9, and 12. The study may be extended to continue giving patients access to treatment.
* End-of-Study Phase: An end-of-study contact either as an office visit or follow-up telephone call will occur one month after the last infusion.

Eligibility Criteria:
Inclusion Criteria:

1. Confirmed diagnosis of Fabry disease.
2. Patient is willing and able to provide written informed consent, and assent if applicable.
3. Females of childbearing potential must agree to use a method of birth control throughout the study and for at least 30 days after the final infusion. The method of contraception must be considered adequate and appropriate in the opinion of the investigator.

Exclusion Criteria:

1. Hypersensitivity to Replagal, the active substance, or any of the excipients.
2. The patient is pregnant or breast feeding.
3. Concomitant use of agalsidase beta (Fabrazyme).
4. Has received treatment with any investigation drug or device within the 30 days prior to study entry.
5. Otherwise unsuitable for the study, in the opinion of the Investigator.
Local Infiltration Versus Block Against Pains After High Tibial Osteotomy

The purpose of this study is to elucidate whether patients operated with high tibia open-wedge osteotomy for osteoarthritis of the knee can be treated more appropriately, so that both healing and rehabilitation are served optimally.

Axis corrective surgery of the knee is an attractive alternative to the knee prosthesis in young active patients with unilateral osteoarthritis of the knee. The purpose of this study is to elucidate whether patients operated with high tibia open-wedge osteotomy for osteoarthritis of the knee pain can be treated more appropriately, so that both healing and rehabilitation are served optimally.

Proximal open-wedge tibia osteotomy is an accepted treatment option for younger patients with unilateral osteoarthritis of knee. 70 such operations are performed in the investigators Orthopaedic Divisions each year. The surgery involves cutting through the upper end of the tibia and opens the bone using specialized instruments. The tibia is lengthened on the medial side with the purpose of correcting the mechanical axis of the knee joint. The surgery is associated with many pains in the early postoperative phase. Until now, pain treatment has been controlled with either epidural block, or regional block via femoral catheter. Both treatments may involve risks such as loss of strength and sensibility disturbance, which often prolongs the early recovery and mobilization. Moreover, pain treatment administered via femoral catheter is often not sufficient as a part of the area behind the knee joint is not covered.

With the advent of new pain therapies, particularly intra operative administration of local anaesthetics directly in the operating field and catheter administration for postoperative pain management, there is hope that those disadvantages are eliminated. By ensuring an effective pain treatment and the possibility of early mobilization only hours after completion of surgery, this will allow for better patient care in terms of reduced pain, shorter hospitalization and quicker rehabilitation.

New results show that the healing of bone opening is not compromised by rapid mobilization. The migration of bone parts around the opening is measured by roentgen stereometric analysis (RSA), with a precision of approximately 0.2 mm. This verifies stable healing of the bone opening.

Eligibility Criteria:
Inclusion Criteria:

* Planned primary open-wedge high tibia osteotomy
* Patients (male/female) ≥ 18 år
* Patients giving written informed consent and authority.
* Patients receiving epidural anaesthesia

Exclusion Criteria:

* Patients with intolerance to trial medications
* Rejection of or contraindicated epidural anaesthesia
* Patients with rheumatoid arthritis.
* Patients with Body Mass Index (BMI) ≥ 35
* Patients that do not read or write Danish
Measuring the Feasibility and the Effects of Chair Massage on Pain and Discomfort in the Cardiac Sonographer

The purpose of this study is to determine whether the effects of chair massage and/or chair massage with stretching may reduce musculoskeletal pain and discomfort related symptoms associated with the job duties of a cardiac sonographer.

Staff performing echocardiography exams work in a physically demanding environment. The physical and psychosocial demands of the work environment place a significant amount of stress on the physical well being of the employee. The nature of the work involved includes repetitive movements and static holds while applying intense pressure. These compounded by a challenging ergonomic work environment, often leads to physical tension, pain, and fatigue. Staff and patient characteristics, in particular obesity, present greater ergonomic challenges. In this setting, optimal ergonomics can be difficult to achieve. Repetitive actions in an ergonomically challenging environment can have an accumulative effect that can lead to injury.

Massage therapy has been noted to decrease levels of anxiety and fatigue which is essential to maintaining efficient care in a dynamic environment. Repetitive use, typically leads to shortened, tight muscles that fatigue over time. Once the massage therapy has released the connective tissue tension and restored muscle imbalances, exercise focused on core, trunk strength and those muscles which oppose the repetitively used muscles can further assist the therapeutic benefits of massage.

The cardiac sonographer is usually sitting and reaching forward or to the side, and the musculoskeletal imbalances show up primarily superior to the hips. Massage Therapy research for alleviating musculoskeletal symptoms has been with the use of table massage whereas chair massage research has focused on gaining physiological benefits. Chair massage therapy impacts the head, back, neck shoulders, arms and hands so does impact the areas of musculoskeletal imbalance of the cardiac sonographer. In addition, a massage chair is easy to set up, does not need a great deal of space, and can be provided in semi-private area, as the participant remains clothed. Chair massage literature to date has focused more on physiological responses and albeit positive, not as much on musculoskeletal responses.

Eligibility Criteria:
Inclusion Criteria:

* Cardiac Sonographer that, per their job descriptions, are performing echocardiography exams during the weeks of the massage therapy pilot study.
* Men and Women age 18-65 able to give informed consent.
* Able to speak and understand English
* 8-hour per day shift schedule, Monday through Friday

Exclusion Criteria:

* Individuals that decline to participate in the study.
* Individuals being treated for an acute musculoskeletal symptom.
* Individuals currently on work restrictions.
* Undergoing treatments for malignancy
* Pregnancy (due to this being chair massage)
* Recent head, neck, shoulder or back surgeries
* Pins or joint fusion of the head or neck
* Current sinus infections, earaches, or vascular migraines
* Students
Testing Radon Com Methods: Clinical Trial Smartphone App vs Print Brochures

The purpose of this research study is to compare the effectiveness of radon information delivered via the radon app vs. a traditional approach (printed brochure). The prevalence of exceptionally high levels of residential radon in ND, coupled with public's poor understanding of this hazard, is a critical public health problem.


Eligibility Criteria:
Inclusion Criteria:

* The principal eligibility criterion is that participants own a smartphone.

Exclusion Criteria:

* The principal exclusion criterion is previous testing for radon within the past two years.
The Effectiveness of Kinesio Taping in Patients With Chronic Low Back Pain

The objective of this study is to determine the effectiveness of Kinesio taping (KT) with Conventional Physical therapy (CPT) - Transcutaneous Electrical Nerve Stimulation (TENS) and Supervised Exercise therapy and CPT in the management of CLBP.

Chronic low back pain (CLBP) is one of the most common causes of chronic disability which leads to major social and economic consequences. The role and effectiveness of the Kinesio taping (KT) and Conventional Physical therapy (CPT) are evident from the existing literature but no comparison was found on the combination of other physical therapy techniques such as supervised exercise therapy and Transcutaneous Electrical Nerve Stimulation (TENS) with CLBP in the Kingdom of Saudi Arabia

Eligibility Criteria:
Inclusion Criteria:

* Pain caused by mechanical/nonspecific low back pain.
* Degeneration of the spine and intervertebral disc.
* The visual analog scale of pain 4 and above
* Low back pain for at least three months

Exclusion Criteria:

* Physical therapy treatment is taken in the past 6 months period
* Previous spinal surgery with fixation
* Structural anomalies
* Spinal cord compression
* Severe osteoporosis
* Acute infections
* Severe cardiovascular or metabolic diseases
* Pregnant women
Prevention of Hamstring Injuries in Football Players.

Introduction: The prevalence of hamstring injuries in football is high, causing an increase in the number of casualties and a high socio-economic cost. Currently there are different treatment protocols for this muscle group, but there are often no comparisons of different types of passive, active and combined therapies, and their potential efficacy, in professional football players.

Objectives: To compare the efficacy of three different interventions; passive manual therapy, active therapy based on therapeutic exercise and combined therapy, in relation to hamstring injuries in professional football players.

Methodology: A simple Randomised Clinical Trial (RCT) was conducted (NCT04935398). After applying the selection criteria, a sample of 66 professional football players was obtained. They were divided into 3 intervention groups (A, B and C) with 22 participants in each group and were given passive manual therapy, active therapy (exercise) and combined therapy (sum of the above). The corresponding tests and questionnaires were evaluated to obtain data on hamstring flexibility and hip range of movement at three time periods: pre, post and post2.


Eligibility Criteria:
Inclusion Criteria:

* Professional football athletes.
* Between 18-40 years of age.
* Male gender.
* Active in competitive season.

Exclusion Criteria:

* Neurological signs.
* Inability to follow the evaluator's instructions.
* Physical activity of less than 2 hours per week.
* Serious lower limb injury during the study period.
Randomised Study of Concomitant Radiochemotherapy in Non-small Cell Lung Cancer

The purpose of the present trial is to assess if induction concurrent chemoradiotherapy followed by consolidation chemotherapy will improve survival in comparison with the same chemotherapy given as induction followed by consolidation concurrent chemoradiotherapy.


Eligibility Criteria:
Inclusion Criteria:

* Histological or cytological diagnosis of non-small cell carcinoma of the lung
* Initially unresectable non-metastatic stage III disease
* Availability for participating in the detailed follow-up of the protocol
* Presence of an evaluable or measurable lesion
* Written informed consent
* No functional or anatomical contraindication to chest irradiation

Exclusion Criteria:

* Prior treatment with chemotherapy, radiotherapy or surgery
* Performance status \< 60 on the Karnofsky scale
* History of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix or cured malignant tumour (more than 5 year disease-free interval)
* Neutrophils \< 2,000/mm³
* Platelet cells \< 100,000/mm3
* Serum bilirubin \> 1.5 mg/100 ml
* Hepatic disease contra-indicating the administration of docetaxel and/or GOT or GPT ≥ 2.5x the normal value and/or alkaline phosphatase ≥ 5x the normal value
* Serum creatinine \> 1.5 mg/100 ml and/or creatinine clearance \< 60 ml/min
* Recent myocardial infarction (less than 3 months prior to date of diagnosis) or uncontrolled angina pectoris
* Congestive cardiac failure or cardiac arrhythmia requiring medical treatment
* Uncontrolled infectious disease
* Symptomatic polyneuropathy
* Auditive impairment contra-indicating cisplatin administration
* Serious medical or psychological factors which may prevent adherence to the treatment schedule
* Malignant pleural or pericardial effusion
* Homolateral supraclavicular lymph node excepting upper lobe lesion
* Heterolateral supraclavicular lymph node
* Known hypersensitivity to docetaxel or cisplatin
* Pregnancy or for pre-menopausal patient, incapacity to use adequate contraceptive method
Comparison Among the Effects of Blood Flow Restriction Training and Conventional Exercise in Knee Osteoarthritis.

The main objective of the study is to compare the effects of Blood flow Restriction training vs. traditional exercises on knee pain , knee functional disability and on quadriceps strength in patient with knee osteoarthritis.

Osteoarthritis is a degenerative disease affecting the most commonly weight bearing joint.The common form of arthritis is osteoarthritis (OA) causing structural changes in the joint. Age is a common factor affecting the strength and muscle mass.Worldwide there is a drastic increase of osteoarthritis in the older population. In the past 20 years the prevalence of knee pain increased and reached up to 50% in the older population. The most common OA affecting lower extremity is in the knee Joint.Majority of the people affected by knee OA are the older population. Knee Joints being the most weight bearing joint affected in OA causing pain , limiting function and mobility.Mobility and function may be affected in osteoarthritic population usually experience pain and stiffness.

The main objective of this study is to compare the Effects of blood Flow restriction training vs conventional treatment exercises on knee pain, functional disability and quadriceps strengthening.

The main purpose of this study is to improve the muscular strength of lower limbs which are being affected in a disease osteoarthritis in the adult population.

Eligibility Criteria:
Inclusion Criteria:

* Pain : Subjects having unilateral or bilateral pain
* Pain type : subjects having chronic pain
* Includes diagnosed cases of knee osteoarthritis
* grades 2-3 according to the Kellgren and Lawrence method of grading
* Includes knee osteoarthritis patients with lateral tracking of patella which will assessed through Q angle test

Exclusion Criteria:

* Any other orthopaedic or neurological condition of hip and knee
* Sign and symptoms of lower motor neuron disease
* Current use of medication
* Radiculopathy
* Fracture
* Malignancy
* Thromboembolism
* Decreased range of motion
Understanding Neurocognitive Impairment After Trauma Exposure

Individuals living in Canterbury (New Zealand) have experienced significant stress related to the Canterbury earthquake sequence. Previous research conducted at the Department of Psychological Medicine (Christchurch, New Zealand) has shown significant cognitive difficulties in a group of Cantabrians exposed to high levels of earthquake trauma. A high proportion (30%) perceive themselves to have significant cognitive difficulties, even seven years post-earthquake. People who perceive that they have cognitive difficulties find this distressing and tend to function less well in work and parenting. Understanding pathways underlying cognitive difficulties in the population is vital for developing appropriate treatments and strategies to help with this.

This will be the first study to investigate rates of, and factors contributing to, perceived cognitive difficulties in a large population exposed to multiple stressors and is important for the population of Canterbury, and populations affected by natural and man-made disasters worldwide.

Four hundred and sixty people who were exposed to the Canterbury earthquake sequence will be recruited from the Christchurch Health and Development Study (CHDS). Psychological, cognitive, functional and biological factors will be compared between those with the greatest levels of perceived cognitive difficulty and those with the lowest levels of difficulty. This will determine what factors relate most strongly to perceived cognitive difficulties, which will in turn be used to develop treatments for this population.


Eligibility Criteria:
Inclusion Criteria:

* Cohort member of the Christchurch Health and Development Study (born in 1977)
* Exposed to the Canterbury earthquake sequence
* In the highest or lowest quartile with regards to score on the Cognitive Failures Questionnaire

Exclusion Criteria:

* lifetime diagnosed psychotic disorder
* previous moderate to severe head injury (\> 30 minutes loss of consciousness)
* current pregnancy
* intellectual disability (IQ \< 80)
* residing outside of Canterbury
Detrusor Activity Recovery in Acute Traumatic Spinal Cord Injuries

Determining the most appropriate time to evaluate detrusor activity in urodynamic studies for both traumatic and non-traumatic spinal cord injuries

The detrusor activity in the acute phase of the spinal cord injury changes with the development of the spinal shock. Spinal shock is a phase of areflexic phase after the spinal cord injury that is primarily influenced by the severity of the injury and the neurological level of injury. Detrusor activity shows areflexic in the spinal shock phase, followed by a return of detrusor activity at the end of the spinal shock.

There was no recent study to provide evidence of an appropriate time to assess detrusor muscle activity through urodynamic studies. There were only a few limited studies on detrusor activity following spinal cord injury from 1960 to 1970. However, when the urodynamic study should be performed is still controversial.

Knowing the patterns of detrusor activity following spinal cord injuries is critical to determining the appropriate timing for intermittent catheterization, which is the standard emptying method of choice. If clinicians fail to understand true detrusor activity as early as possible, the patient will suffer from unnecessary indwelling catheter voiding, resulting in impaired quality of life in the acute phase.

Eligibility Criteria:
Inclusion Criteria:

* Acute onset suprasacral spinal cord injury with both traumatic and non-traumatic causes within the first 15 days after spinal cord injury(very acute phase of SCI according to European Multicenter Study about SCI : the first 15 d (very acute), between 16-40 d (acute I), and 3 mo (acute II), 6 mo (acute III), and 12 mo (chronic) after SCI)
* Age older than 18
* Inpatient
* Patients with spinal cord injuries who initially keep the indwelling catheter
* Patients with or without spinal shock

Exclusion Criteria:

nstable vital sign (using Inotropics or vasopressors or antiarrhythmic agents)

* Current urinary tract infection
* Agitated behavior (Richmond Agitation and Sedation Scale of +2 to +4)
* Decreased mentality (RASS of -2 to -5)
* Concomitant sacral lesions (Ex. Sacral fracture, pelvic bone fracture, urologic trauma)
* Concomitant supraspinal lesions (Ex. Traumatic brain injury, old stroke, Parkinson disease)
* Uncontrolled DM
* Medical history of lower urinary tract dysfunction (Ex. BPH, Malignancy)
* Uncontrlled autonomic dysreflexia (In case of autonomic dysreflexia, defined according to ISAFSCI (International Standards to document remaining Autonomic Function after SCI) as an increase in systolic blood pressure 20 mm Hg or greater from baseline