cyrilzakka/clinical-trials huggingface dataset:
Measuring the Electrical Properties of Malignant Tissues Ex Vivo

Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. While the EP informations of cancer tissues are not sufficient enough. The purpose of this study is to measure the electrical properties of the excised malignant tissues obtained from cancer surgeries.

The measurements were conducted in the operating rooms of the hospital where the tissues were excised. Once the tissue was excised from the patient, the pathologist assisted the one of the engineers (already at the hospital) responsible to conduct the measurement. The specimen were designed to permit at least one measurement of malignant tissue and at least one measurement of normal tissue. Occasionally, the measurement of normal tissue was not possible if, for example, the normal tissue occupied a volume of small proportion for every excised specimen. The specimens for dielectric properties measurement were classified as normal or malignant by the pathologist based on his own expertise and decision criteria (visual inspection, anatomy) and the per-operative histological examination. The measurements were directly performed on the bulk specimen. The patient age, tissue temperature at the time of measurement and time between excision and measurement for each sample were recorded.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of cancer Disease

Exclusion Criteria:

* None
Movement Therapy and Childhood Obesity

The Child health and Sports Center, Meir Medical Center, has an intervention program to treat obese children. The program includes physical activity, nutritional intervention and behavioral treatment.The emphasis given in the center to physical activity and sport enables a strong connection with movement therapy. Movement therapy allows obese children to face and cope with the psychological and emotional aspects of obesity.

The purpose of this study is to evaluate the contribution of the movement therapy intervention to our program.

Movement therapy is part of the multidisciplinary intervention. Weekly one hour long sessions are conducted under the guidance of a certified therapists.

The meeting includes physical movement aimed to address the emotional world of the obese child. Using games, structured exercises and verbal processing.

At the start and end of the evaluation the children will answer questionnaires to study:

1. Behavioral questionnaires:emotional state: anxiety, depression, communication, self-esteem, quality of life and self-efficacy.
2. Demographic questions . At the beginning and the end of the program a certified movement therapist will observe the children to estimate the change of emotional movement.weight, height and BMI are measured regularly in the center.

Eligibility Criteria:
Inclusion Criteria:

* Overweight/obese children

Exclusion Criteria:

* Child that do not want to take part in this study
Cervical Stabilization Exercises on Bruxism and Sleep Quality

Bruxism and temporomandibular joint dysfunction are common conditions today. The applications in the treatment of these disorders are limited. When the literature is examined, it has been determined that cervical stabilization exercises, which are frequently applied in physical therapy clinics for neck problems, have not been applied to bruxism before. For this reason, in this study, we will examine the effects of cervical stabilization exercises targeting deep cervical muscles on bruxism.

Bruxism is the grinding or clenching of teeth, which is characterized by the fixed or forward movement of the mandible that occurs repeatedly during the day, including muscles such as the masseter and temporal muscles. Correct determination of the etiology plays a key role in the treatment of bruxism. There are many suggestions in the literature for the treatment of bruxism. The most preferred of these are: providing training for the person to quit harmful habits, physiotherapy applications for muscle relaxation, botox applications, drug treatments, giving the patient an occlusal splint, etc. Since bruxism is a functional problem of muscular origin, it is possible to talk about muscle-oriented exercise applications in its treatment. As a result of studies in which exercises are frequently prescribed for the chewing muscles and temporomandibular muscles, it has been determined that bruxism symptoms are relieved and functional gains are achieved. It has also been stated that muscle pain and activity, mouth opening, oral health, anxiety, stress, depression and head posture can be improved in individuals with bruxism with physiotherapy approaches. When the literature is examined; There are studies investigating the effects of physiotherapy applications in bruxism. In addition, although it is known that the neck region is affected in bruxism, causing the head to tilt forward and increased muscle activation in the neck region, no study has been found investigating the effects of specific cervical region stabilization exercises. This study was planned considering the effects of cervical stabilization exercises on correcting cervical posture and providing muscle activation balance.

Eligibility Criteria:
Inclusion Criteria:

* Patients with full dentition including 2nd molars
* Patients without facial asymmetry

Exclusion Criteria:

* Patients with systemic and/or neuromuscular diseases
* Patients with orofacial pain not caused by bruxism
* History of temporomandibular joint (TMJ) surgery or injection
* Use of any medical drugs affecting the muscular system
* Patients with developmental deformities or a history of surgery in the maxillofacial region (facial trauma history, resection history, etc.)
* TMJ pathologies (major condylar changes seen on panoramic radiographs)
* History of radiotherapy and/or chemotherapy
* Ongoing orthodontic treatment
* Use of removable prosthesis
* Inflammatory connective tissue diseases
* Pregnancy
* Obstructive sleep apnea
* Local skin infection over the myofascial area
* Patients who have undergone root canal treatment
* Reluctance to take responsibility for the work
A Study to Analyze Data on Metastatic Ovarian Cancer Using Multi-omics

As one of the most common malignant tumors in women, the incidence of ovarian cancer is expected to increase year by year. Due to its lack of typical symptoms and effective screening methods, and the characteristics of implantation and distant metastasis, more than 70% of ovarian cancers were in the metastatic stage at the time of diagnosis. In this study, the investigators will collect large samples of tissue from patients with ovarian cancer, conduct multi-omics studies, and mapped the characteristic maps of the genome and transcriptome of patients with metastatic ovarian cancer, and explore the molecular mechanisms that can be used as new targets for the treatment of ovarian cancer. Besides, the investigators will design and establish a database of metastatic ovarian cancer, integrate multiple omics, imaging, pathology, and clinical information to study their potential relevance, and analyze the relationship between various omics, imaging, pathology, and prognosis, establish ovaries Cancer prediction model.


Eligibility Criteria:
Inclusion Criteria:

1. female, ≥18 years old;
2. diagnosed as ovarian cancer by imaging and pathology;
3. did not receive any anti-tumor drug treatment before surgery in the gynecology clinical department of the Sun Yat Sen Memorial Hospital of Sun Yat-Sen University;
4. received ovarian cancer surgery and Follow-up treatment;
5. Patients voluntarily participate in the research of this subject, have good compliance, and can complete the enrollment by the requirements of the trial;
6. Sign informed consent and agree to the collection and use of their data.

Exclusion Criteria:

1. Patients who have received other anti-tumor treatments or received tumor surgery before enrollment;
2. Patients with malignant tumors in other parts;
3. Patients with uncontrollable neurological, psychiatric, or mental disorders;
4. Poor compliance and inability to Cooperate and describe treatment responders.
Comparison of Triggers in Double Ovarian Stimulation (DuoStim).

This study aims to investigate the efficacy of 3 different trigggers used for final maturation in the second ovarian stimulation in double stimulation protocol (aGnRH and hCG-rec vs. aGnRH only vs. hCG-rec only). The main objective is to compare the number of all retrieved oocytes and mature oocytes in patients predicted to be low ovarian responders.

This is a controlled randomized clinical study where 165 patients will be recruited.


Eligibility Criteria:
Inclusion Criteria:

* BMI below 32
* Presence of both ovaries
* Indication for ovarian stimulation under Double Stimulation protocol (Duo Stim)
* Meeting the criteria for Duo Stim
* Medical history, history and physical examination without alterations
* AMH and AFV results in accordnace to Poseidon classification group 3 or 4 no more than 6 months prior to signing the consent form
* Ability to participate and comply with the study protocol.
* To have given written consent
* Normal karyotype and fragile X.

Exclusion Criteria:

* Non-compliance with instructions and/or non-formalization of consents or legal requirements for IVF.
* Concurrent participation in another study
Study of the Effect of Testosterone Treatment on Metabolic Parameters and Urinary Symptoms in Bariatric Patients

The primary purpose of the study is to evaluate, in obese and hypogonadal patients eligible for bariatric surgery, the effect of testosterone replacement therapy in improving lower urinary tract symptoms (LUTS) assessed using the IPSS (International Prostate Symptom Score) questionnaire, compared to hypogonadal untreated subjects and eugonadal subjects.

Primary objective:

- Evaluation in obese and hypogonadal patients candidates for bariatric surgery of the effect of testosterone replacement therapy in improving the symptoms of LUTS (assessed using the IPSS questionnaire) compared to hypogonadal untreated subjects and eugonadal subjects.

Secondary objectives:

* Evaluation of the effect of testosterone in obese and hypogonadal patients candidates for bariatric surgery in improving metabolic parameters (glycaemia, oral glucose tolerance test, HbA1c, total cholesterol, HDL cholesterol, triglycerides, arterial pressure, BMI, waist circumference) compared to hypogonadal untreated subjects and eugonadal subjects
* Evaluation of the effect of testosterone in obese and hypogonadal patients candidates for bariatric surgery in improving uroflowmetric parameters compared to hypogonadal untreated subjects and eugonadal subjects
* Evaluation of the effect of testosterone in obese and hypogonadal patients candidates for bariatric surgery on the ultrasound characteristics of the prostate (macro-calcifications, intraprostatic arterial velocity, volume of the prostate gland).
* Evaluation of the effect of testosterone in obese and hypogonadal patients candidates for bariatric surgery on pre-adipocytes isolated from visceral adipose tissue samples collected during surgical procedures, as compared to hypogonadal untreated subjects and eugonadal subjects.

Eligibility Criteria:
Inclusion Criteria:

* Male subjects
* Age between 25 and 65 years
* Obese men, candidate to a bariatric surgery (body mass index (BMI) is ≥40 kg/m2, or if their BMI is \>35 kg/m2 and they suffer from other life-threatening co-morbidities such as Type 2 Diabetes Mellitus, hypertension and cardiovascular disease)
* Men with LUTS defined by: IPSS ≥ 8.
* Evidence of a personally signed and dated informed consent

Exclusion Criteria:

* Bladder failure or Neurogenic bladder
* LUT disease (Urethral stenosis, diverticula)
* LUT surgery (Prostatectomy, bladder neck surgery, TURP)
* Severe systemic disease
* Previous or concomitant neoplasm
* Unable to consistently and accurately complete the protocol
* Abuse alcohol or drugs
* Psychiatric disease
Pragmatic Assessment and Treatment for the Health System

The project goal is to promote a feasible and effective approach to communicative disorders in neurological and psychiatric populations, focused on the pragmatics of language. Pragmatics allows speakers to use and interpret language in context and to engage in successful communication. Pragmatic language disorder is widespread in clinical conditions and causes reduced social interactions and lower quality of life for both patients and their family. Yet it is seldom considered in assessment and rehabilitation.

The project aims at developing a comprehensive approach for the assessment and treatment of pragmatic impairment in neurological disease. It consists of three Work Packages:

* The aim of WP1 is to develop a short test of pragmatic abilities. 200 healthy participants will be enrolled for this WP, and the same test will be administered to 40 patients with right hemisphere damage, 40 with traumatic brain injury, and 50 with Schizophrenia.
* The aim of WP2 is to test the efficacy of a novel treatment for pragmatic disorder. 32 patients will be enrolled (16 for each patient group) and allocated (via Randomized Control Trial) to a standard treatment or to a novel treatment for pragmatic disorders. Only RHD and TBI will take part to this WP.
* The aim of WP3 is to better clarify the neural correlates of pragmatic abilities. All patients will undergo an high density EEG recording session, and their brain activity will be correlated with performance on neuropsychological tests and on pragmatic impairment. The RHD and TBI patients enrolled for WP2 will undergo a session of hd-EEG also at the end of rehabilitation to monitor brain changes after treatment.

Eligibility Criteria:
Inclusion Criteria:

Healthy participants

* no neurological disorder
* written informed consent Right Hemisphere Damage (RHD)
* unilateral stroke
* first stroke
* no comorbidities with psychiatric disorders
* written informed consent TBI
* traumatic brain injury
* written informed consent

Schizophrenia:

* Diagnosis of Schizophrenia
* written informed consent

Exclusion Criteria:

* Important comorbidities that may affect results
Evaluation of a Protocol for Multidisciplinary Management of Acute Cholecystitis.

Acute cholecystitis is a complex disease and its management is sometimes controversial. Two main factors contribute to its complexity: the patient's surgical risk and the possibility of concomitant choledocholithiasis. The design of a multidisciplinary protocol between the services of Gastroenterology and Surgery aims to harmonize its management and to adapt it to the most recent guidelines. As it concerns more than one department, it is crucial to analyze its compliance and effectiveness.

Adult patients attending the emergency department and diagnosed with acute cholecystitis will be asked to participate. Those considered not suitable for surgery will be admitted in a medical department and assigned to conservative treatment or cholecystostomy, according to their acute cholecystitis severity. In patients suitable for surgery, risk of concomitant choledocholithiasis will be assessed and patients will be assigned to low risk or intermediate-high risk. The latter will be admitted in a medical department, and choledocholithiasis will be ruled out and treated if present. The former will be offered cholecystectomy or cholecystostomy according to their surgical risk and acute cholecystitis severity. A flowchart with extended information is attached.

PRIMARY OBJECTIVES

• To harmonize the management of acute cholecystitis with a multidisciplinary protocol based on the most recent guidelines.

SECONDARY OBJECTIVES

* To analyze the compliance with this protocol.
* To evaluate the validity of the criteria used in the decision-making process.
* To assess the morbidity and mortality of different groups of patients according to the selected treatment, severity of cholecystitis and baseline characteristics of the patient.
* To estimate the resource use in each group of patients.
* To compare current data with a previous period.
* To adapt and modify the protocol according the study results. INCLUSION CRITERIA
* Patients aged 18 or older who agree to participate (an informed consent signature is required)
* Patients attended in the emergency department of our hospital and diagnosed with acute cholecystitis according to the Tokyo criteria.

EXCLUSION CRITERIA

* Patients under 18 years or patients who refuse to participate in the study
* Patients diagnosed with acute cholangitis during admission for other causes.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 or older who agree to participate (an informed consent signature is required)
* Patients attended in the emergency department of our hospital and diagnosed with acute cholecystitis according to the Tokyo criteria.

Exclusion Criteria:

* Patients under 18 years or patients who refuse to participate in the study
* Patients diagnosed with acute cholangitis during admission for other causes.
Multimodal Analgesia After Shoulder Arthroscopy

This proposal aims to measure the quality of recovery and quality of pain management after shoulder surgery before and after implementation of a multimodal pain protocol.

Pain management after shoulder surgery remains to be a major challenge. Reliance on a single agent (most commonly opioids) results in increased incidence of side effects. Multimodal pain management refers to the use of multiple drugs that target different components of pain pathway.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients
* Age 18-80
* Speaks and understands the English language
* Have a phone number
* Scheduled for shoulder arthroscopy

Exclusion Criteria:

* Inability to read or speak English
* Individuals outside of age range
* Pregnant women
* Persons under the jurisdiction of the Department of Corrections
Real Life Evaluation of Rheumatoid Arthritis in Canadians Taking HUMIRA

The purpose of this study is to evaluate the clinical effectiveness and safety of adalimumab as used in routine clinical practice in adult participants with moderate to severe rheumatoid arthritis (RA) in Canada.

REACH is an observational survey of participants with moderate to severe rheumatoid arthritis taking adalimumab. Participants who volunteer will be asked to provide information about their medical history and experiences with adalimumab. No drug will be provided as a result of participation in the registry. All treatment decisions are independent of participation in the registry.

Eligibility Criteria:
Inclusion Criteria:

* Participant is eligible to take part in the registry as per the product monograph.
* Participants that are naïve to adalimumab therapy / or participants that have been receiving adalimumab therapy for less than 4 months.
* Participant has moderately to severely active RA.
* Participant who has had an inadequate response to one or more Disease Modifying Anti-Rheumatic Drugs (DMARDs).
* Participant received provincial or private (insurance companies) approval for adalimumab.
* Participant is able to give written informed consent and to understand the survey requirements.

Exclusion Criteria:

* Participant to whom a traditional DMARD had never been tried.
* Participant with a known hypersensitivity to adalimumab, or any of its components.
* Participant is receiving free adalimumab as part of a compassionate program or an early access drug distribution program.
* Participant with clinically significant concurrent medical or psychiatric disorders that may influence survey outcomes.
* Participant with any condition that would prevent participation in the survey and completion of the survey procedures including language limitation or possibility that the participant will not be available for a period of time (\> 12 months) while being enrolled in the survey.
Very Early Rehabilitation in Acute Ischemic Stroke

The purpose of this study is to evaluate the effectiveness of a rehabilitation (physiotherapy) program in patients with acute ischemic stroke in Acute Vascular Unit and in general ward of Hospital de Clínicas de Porto Alegre, and to verify the degree of disability at fourteenth and third month, functional improvement at third month, the frequency of deaths and incidence of complications due to immobility and quantify the time spent in hospital.


Eligibility Criteria:
Inclusion Criteria:

* Patients with clinical diagnosis of acute ischemic stroke (first or recurrent) confirmed by CCT or MRI admitted to the Acute Vascular Unit of HCPA between the first 48 hours of onset of symptoms.
* Patients older than 18 years.
* Patients clinically and hemodynamically stable (SBP 120-220 mmHg, SatO2 up to 92% with or without supplementation, HR between 60 and 100 bmp, body temperature below 38 and RR below 25 bpm).
* Patients are able to react to verbal commands even without being fully alert (Glasgow Scale above 8).
* Prior Rankin until 3
* Motor deficit and / or coordination measured by the NIHSS

Exclusion Criteria:

* Patients with clinical and / or hemodynamic instability
* Patients with hemorrhagic stroke or TIA (transient ischemic attack).
* Patients with progressive neurological disease and acute coronary disease and / or unstable.
Growth and Weight Gain in ELBW Infants Fed an Exclusively Human Milk Based Diet With Prolacta®

Preterm infants are susceptible to postnatal growth restriction. Breast milk is the recommended source of nutrition for preterm infants. As preterm infants have enhanced nutritional requirements, multicomponent fortifiers are added to breast milk in order to establish adequate growth.

Due to the various benefits of human milk feds to preterm infants, a human milk fortifier based on donor milk (Prolact+6 H2MF® Prolacta, City of Industry, California) has been developed. With this study, the investigators want to evaluate the effect of human milk fortification on weight gain in extremely low birth weight infants (ELBW, \<1000g birth weight) in comparison to bovine fortification.

Preterm infants are susceptible to postnatal growth restriction. Breast milk is the recommended source of nutrition for preterm infants. Many positive short-term health effects like prevention necrotizing enterocolitis , effects on gut development and immunological issues are associated with breast milk feedings.

The composition of breast milk usually meets the nutritional demands of term infants. As preterm infants have enhanced nutritional requirements, multicomponent fortifiers are added to breast milk in order to establish adequate growth and proper neurodevelopmental outcome.

Due to the various benefits of human milk feds to preterm infants, a human milk fortifier based on donor milk (Prolact+6 H2MF® Prolacta, City of Industry, California) has been developed. This human milk fortifier contains more energy and protein than bovine milk fortifiers. So far, accurate data on growth and weight gain under an exclusive diet with human milk and the human milk fortifier Prolact+6H2MF®are missing. With this study, the investigators want to evaluate the impact of a human milk based fortifier on weight gain in extremely low birth weight infants (ELBW, \<1000g birth weight) in comparison to bovine milk based fortifier.

Eligibility Criteria:
Inclusion Criteria:

* Preterm infants with a birth weight \<1000 g

Exclusion Criteria:

* Congenital heart disease
* Major congenital birth defects
* Major inborn error of metabolism