cyrilzakka/clinical-trials huggingface dataset:
Evaluation and Rehabilitation for Coordinated Control of Bilateral Ankle Joints in Stroke Patients

The coordinated control between the bilateral ankles plays an important role in daily life functions such as walking and balance. The central nervous system damage caused by stroke, in addition to the limitation of the ankle movement on the hemiplegic side and the deterioration of the movement ability, It will seriously affect the coordinated control performance between the bilateral ankle joints, which will cause the majority of stroke patients to have barriers to walking function, and increase the patient's daily care depending on the caregiver. However, there is currently no research on stroke patients, the development of a coordinated control evaluation method with bilateral ankle joints, the use of load-bearing state simulation similar to the real-life bilateral ankle and foot coordination control performance, the establishment of clinical value of bilateral ankle Coordinating the performance parameters of the control evaluation; thus, the clinical doctors can not accurately understand the degree of defect in the bilateral foot and ankle coordination control of the stroke patients, and explore the influence of the bilateral ankle-foot coordination control defect on the daily life function of the stroke patients, and even cannot be based on the evaluation results. The clinical parameters, combined with visual feedback and bilateral rehabilitation advantages of rehabilitation training program, improve the bilateral ankle joint coordination control ability and lower limb function of stroke patients. Therefore, the purpose of this study is to establish an assessment system that can be used to measure the performance of bilateral ankle joint coordination control, to understand the degree of injury in bilateral ankle and foot coordination control, and to analyze the biped coordination parameters and clinical gait performance. The characteristics, and then the design of a double-sided rehabilitation training program combined with visual feedback, is used to improve the bilateral ankle joint coordination control performance and lower limb movement function of stroke patients.


Eligibility Criteria:
Inclusion Criteria:

1. at least 6 months since stroke
2. three or fewer incidents of unilateral stroke confirmed by taking the participant's medical history
3. ability to follow the researcher's instructions
4. the ability to flex and extend the paretic lower limb and ankle
5. Modified Ashworth Score (MAS) ≦3 for the ankle joints
6. a Mini-Mental State Examination (MMSE) score of 24 or higher
7. no other orthopedic or neurological disorders
8. Brunnstrom stage 4
9. no participation in other experimental rehabilitation or drug studies

Exclusion Criteria:

1. unstable cardiovascular conditions
2. uncontrolled hypertension (190/110 mm Hg)
3. severe orthopedic or pain conditions
4. dementia (Mini-Mental State Examination score \< 22)
5. aphasia with inability to follow researcher's commands
6. Visual dysfunction
7. severe joint contracture of bilateral lower limb extremities that would impact the movement performance of the lower limb extremities
Investigation of the Efficacies of Multi Berries Juice on Anti Oxidant Effect and Improvement of Skin Conditions

To assess multi berries juice on anti-oxidant effect and skin condition improvement


Eligibility Criteria:
Inclusion Criteria:

* Healthy adults aged above 20 years old

Exclusion Criteria:

* Subject who is not willing to participate in this study.
* Patients with diseases of the skin, liver, kidney.
* Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
* Female who is pregnant or nursing or planning to become pregnant during the course of the study.
* Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
* Constant drug use
Extension Study of Pegylated Somatropin to Treat Growth Retardation Caused by Endogenous Growth Hormone Deficiency in Children

1. To further evaluate the safety and efficacy of PEG-Somatropin in the treatment of children with growth hormone deficiency for a relatively long period
2. To explore the factors influencing the efficacy of PEG-Somatropin and to establish the height prediction model based on Chinese children with short stature, and to provide the basis and guidance for standard and reasonable long-term clinical application of PEG-Somatropin.


Eligibility Criteria:
Inclusion Criteria:

* Children has completed all visits and therapy in previous phase IV study;
* Investigators evaluate subjects could continue growth hormone therapy;
* Subjects is willing and able to cooperate to complete scheduled visits, treatment plans and laboratory tests and other procedures, to sign informed consent.

Exclusion Criteria:

* Children with epiphyseal closure;
* Children is near the adule final height, that is, growth rate≤ 2 cm / year or bone age ≥ 14 years old for girls, bone age ≥ 16 years old for boys;
* Dysfunction of liver and kidney (ALT\> 2 times the upper limit of normal, Cr\> upper limit of normal);
* Patients with known hypersensitivity to PEG-Somatropin or Somatropin or any other components of the study product;
* Patients with severe cardiopulmonary or hematological diseases, a current or past history of malignant tumors, immunodeficiency diseases, or mental diseases;
* Patients with diabetics;
* Patients with congenital bone dysplasia or scoliosis;
* Patients took drugs that would influence the efficacy and safety of PEG-Somatropin after phase IV study and before screening for this extension study;
* Other conditions in which the investigator preclude enrollment into the study.
Pilot Study: The Effects of Medical Music on Anxiety in Patients With ILD

This is uncontrolled, interventional feasibility study for determining the effects medical music on anxiety levels in subjects with ILD. Enrolled subjects will be asked to complete questionnaires and undergo physiologic measurements prior to listening to medical music. The music intervention will be for approximately 30 minutes. Post intervention questionnaires and physiologic measurements will be done.

The Medical Music intervention includes playlists that contains songs specifically designed, recorded, and optimized through the provisionally-patented methods, to treat their co-morbid anxiety. The duration of the medical music playlist is 30 minutes.

Enrolled subjects will be asked to complete questionnaires to assess anxiety, a questionnaire related to their music preferences, and undergo physiological measurements (vital signs, galvanic skin response, and heart rate variability) before and after the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Men and women age 50 to 80 years old
* Diagnosis of definite or probable interstitial lung disease (ILD)
* Willingness to participate and sign consent

Exclusion Criteria:

* Patients who are deaf
* Inability to provide informed consent
* Pregnant women
Investigation of the Effects of Chronotype Differences on Balance and Muscle Strength in Young Adults

The aim of this study is to investigate the effects of chronotype differences on balance and muscle strength in young adults. Chronotypes of all participants will be determined using the Morningness-Eveningness Questionnaire. All assessment measurements determined for young adult individuals will be performed first at 09:00 in the morning and then again at 19:00 in the evening.

The aim of this study is to investigate the effects of chronotype differences on balance and muscle strength in young adults. Inclusion criteria are being between 45-65 years old, not having any neurological or orthopedic disorders, not having a vestibular disease that causes balance problems. Exclusion criteria are trauma history, anatomical deformities and skeletal system fractures, having a previous injury, and the presence of pain that will prevent participation in the tests. Chronotypes of all participants will be determined using the Morningness-Eveningness Questionnaire. All assessment measurements determined for young adult individuals will be performed first at 09:00 in the morning and then again at 19:00 in the evening. Muscle strength and balance assessments made in the morning and evening will be compared. Chronotypes of the participants will be evaluated with the Morningness-Eveningness Questionnaire, their balance will be evaluated with the One-Legged Standing Test, lower extremity muscle strength with a myometer, and their functionality will be evaluated with the Timed Stand-Up-Sit Test and the 30-Second Sit-Up Test.

Eligibility Criteria:
Inclusion Criteria:

* being between 45-65,
* not having any neurological or orthopedic disorder,
* not having a vestibular disease that causes balance problems.

Exclusion Criteria:

* trauma history,
* anatomical deformities and skeletal system fractures,
* having a previous injury and the presence of pain that would prevent participation in the tests.
Nitazoxanide in Prevention of Secondary Spontaneous Peritonitis

the study is to evaluate the possible efficacy and safety of nitazoxanide as an adjuvant therapy in the secondary prevention of SBP in patient with cirrhosis.

due to high recurrence rate of spontaneous bacterial peritonitis , we will study and evaluate the possible efficacy and safety of NTZ as an adjuvant therapy in the secondary prevention of SBP in patient with cirrhosis.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 21 - 65 years old with cirrhosis and ascites who had at least one previous confirmed episode of spontaneous bacterial peritonitis.

Exclusion Criteria:

* Exclusion criteria included active gastrointestinal bleeding Hepatic encephalopathy (\>grade 2) Hepatocellular carcinoma (HCC) or other malignancies Allergy to used medications.
Neuroimaging of Pain: Changes in Regional Brain Functioning Associated With Amplified Pain and Intensive Treatment

The proposed study will examine how intensive interdisciplinary pain treatment (IIPT, specifically the Rehabilitation for Amplified Pain Syndrome, or RAPS, program at Children's Mercy Hospital) impacts neurofunctional mechanisms of emotional and physical pain processing in patients. There has been recent interest in characterizing the brain regions responsible for processing pain (Wager et al., 2013), but little research has included youth. A better understanding of the physiological mechanisms of pain can lead to better treatment outcomes.

Youth will be scanned before or during the first week of participation in the Rehabilitation for Amplified Pain Syndrome (RAPS) program, and a second time near or just after program completion (typically 3-5 weeks later). One functional MRI task will involve passive viewing of emotional and pain-related images including some that have been widely used in previous neuroimaging research (e.g., the International Affective Picture Set, Human Facial Expressions; alternating positive and negative affect/valence). The other functional MRI task, will involve systematic external application of somatosensory stimulation (pressure) to the hand in alternating blocks. The entire imaging procedure will take approximately an hour. MRI technicians and/or study staff will administer the scanning protocol. Study team will be responsible for the systematic external application of sensory input.

Eligibility Criteria:
Inclusion Criteria:

* Age 13 to 19
* Admitted to the RAPS program for intensive treatment

Exclusion Criteria:

* Inability to participate in imaging due to developmental delay
* Inability or unwillingness to be still during imaging procedures
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain

Using a retrospective review of records, we will conduct a multivariate analysis to examine the relationship between exposure to ketamine, as an analgesic agent in combat related trauma care, the use of additional opioid pain medications, and patient reported pain levels.

This is a retrospective study to determine if there is a relationship between intravenous infusion of ketamine given for analgesia and the use of additional opioid pain medications and patient reported pain levels before and during ketamine usage. The investigator anticipates that records of up to 700 subjects will be reviewed for eligibility. The time period 24 hours before the initial ketamine therapy is initiated along with 24 \& 48 hours after the start of ketamine therapy will be the time periods examined. The average/minimum/maximum pain scores during these time periods will be used. Medication usage will be calculated over the 24 hour time periods.

This protocol is presented as an initial step in exploring the possible relationship between the administration of ketamine as an analgesic agent, the potential reduction in pain medications, and the potential reduction of pain levels. With this the goals/objectives are as follows:

Objectives

1. To compare morphine consumption in battlefield injured patients with acute pain 24 hours before the initiation of a ketamine infusion to the subsequent 48 hours following the start of infusion.
2. To compare average/minimum/maximum pain scores in battlefield injured patients with acute pain 24 hours before the initiation of a ketamine infusion to the subsequent 48 hours following the start of infusion.
3. To describe the pain trajectory in battlefield injured patients with acute pain after the initiation of ketamine infusions.
4. To measure the absolute and proportional incidence of ketamine associated side effects in battlefield injured patients with acute pain following the initiation of ketamine infusions.

Eligibility Criteria:
Inclusion Criteria:

* Battlefield injured from January 2007 to December 2013
* Prescribed a ketamine infusion for acute pain
* Awake, alert (non intubated/sedated), and able to report pain scores 24 hours prior to the start of infusion and up to 48 hours following infusion

Exclusion Criteria:

* Patients who did not receive an injury in theater and did not receive ketamine while being treated by the APS or WRNMMC/WRAMC hospital staff
* No continuous perineural catheter or epidural placement while on ketamine infusion
* Less than 18 years old
A Study to Compare the Pharmacokinetics and Safety of Current Factor VIII Concentrate and Optivate® in Haemophilia A.

The main objective of the study is to compare the pharmacokinetics of Optivate® with the subject's current FVIII concentrate when given as a bolus dose of 50IU/kg. The secondary objective is to compare the first and second pharmacokinetic assessments on Optivate® (and recovery if a subject changes batch) to evaluate Optivate® in terms of clinical tolerance and safety.


Eligibility Criteria:
Inclusion Criteria:

* Previously treated subjects with severe Haemophilia A (\<2% basal FVIII activity) without inhibitor to Factor VIII, at least 12 years of age, currently receiving FVIII concentrate and with more than 20 exposure days.

Exclusion Criteria:

-
Human Empowerment Aging and Disability (HEAD): New Technologies for Neurorehabilitation

Congenital or acquired neurological disorders could lead to consistent motor and cognitive disabilities. The continuity and persistency of a tailored home rehabilitation protocol after recovery is crucial to prevent disease aggravation or relapses. The integration of a web-based new technology in home rehabilitation programme can constitute a functional low cost resource by offering patients off-line (and on-line) monitoring and by proposing new motivating ways of rehabilitation through high tech tools such as serious games.


Eligibility Criteria:
Inclusion Criteria:

* age range 18-85
* Parkinson Disease (PD - mild to moderate) in stable treatment for at least 3 months
* Multiple Sclerosis (MS) without relapses in the last 3 months (EDSS ≤ 6)
* post stroke ( ≥ 6 months after the acute event)

Exclusion Criteria:

* Mini Mental State Examination \< 20
* limited range of motion
* severe pain
* severe deficit of visual acuity or auditory perception or communication and severe dysmetry
Evaluating the Impact of COVID-19 (Coronavirus) on Research in Care Homes

During the COVID-19 (corona virus) pandemic the research arena has had to rapidly adapt and change in order to facilitate and deliver research. The UK (United Kingdom) government and Public Health England have stressed the importance of such research to find solutions to treating, preventing and stopping the spread of COVID-19. Due to national and international 'lock down restrictions' delivering research in care home settings has become even more challenging. The adaptations to conducting consultations have relied heavily on the use of technology, for example video calling, telephone, email, and teleconferencing. It is suggested that the use of technology in care home settings is already a barrier to effective research delivery.

Nevertheless, as care home residents are a vulnerable group, it is critical to include these groups in research in order to enable improved and evidence-based care and their access to new and emerging treatments.

This study aims to assess the opinions and experiences of key stakeholders to identify barriers, and enable better facilitation of research in these settings during and post pandemic.

This two phase project will use a mixed methodology.

Phase one will involve mixed methods surveys. One will be completed by care home residents and the other will be completed by research delivery staff and care home staff.

Phase two will involve qualitative interviews with each of these groups to enable better insight into their views and opinions on research in this area.

Eligibility Criteria:
Inclusion Criteria:

* Any resident of a care home in the West Midlands
* Any relative/friend of a care home resident in the West Midlands
* Any staff member or volunteer working in care home in the West Midlands
* Any researcher undertaking research in a care home in the West Midlands (during the pandemic or proposed during the pandemic period)

Exclusion Criteria:

* Individuals who are unable to give Informed Consent
* Individuals who lack capacity
Systemic Screening for Hereditary Colorectal Cancer in China

The purpose of the this study is to determine the prevalence of germline cancer susceptibility gene mutation among Chinese population, and to find best ways to screen patients with colorectal cancer in China. To accomplish this objective, the investigators will establish a large sample database of hereditary colorectal cancer related information using multigene panel testing based on Next-Generation Sequencing.

Hereditary factors play a very important role in colorectal cancer risk. Identification of the germline cancer gene mutation at the time of colorectal cancer presentation has significant implications for the patients and families, as it directs follow up and clinical options. Professional guidelines recommend patients with colorectal cancer receive a phenotype-driven genetic testing strategies. For example，Lynch syndrome was identified in 2%-4% of patients with CRC using micro-satellite instability (MSI) or DNA mismatch repair (MMR) protein immunohistochemistry (IHC) tumor testing in preselected patients for germline MMR gene testing. However, there is few of clinical characteristics or germline gene mutation data from Chinese population. With the advent of next-generation sequencing (NGS), genetic testing for hereditary CRC has shifted from phenotype-specific single gene assessment to broad panels providing simultaneous assessment of multiple genes implicated in various hereditary cancer syndromes. This study plans to screen and establish a database of 500 consecutive newly diagnosed patients with CRC using multigene panel testing based on Next-Generation Sequencing. The purpose of this study is to:

1. Determine the prevalence of hereditary colorectal cancer and spectrum of germline cancer gene mutation among Chinese population.
2. Evaluate the cost-effectiveness and optimize the design of multigene panel testing.
3. Establish a statewide screening model for hereditary colorectal cancer.

Eligibility Criteria:
Inclusion Criteria:

1. Newly diagnosed with colorectal adenocarcinoma (all stages) patients. For individuals who are old than 70 years old should meet the revised Bethesda Guidelines or polyposis syndromes testing criteria.
2. Agree to provide related information.

Exclusion Criteria:

1. Individuals who are under the age of 18.
2. Individuals who refuse to test.
Poised for Parkinson's - an Intervention to Increase Embodied Agency in People With Parkinson's Disease and Their Carers

The purpose of the study is to develop, deliver, and test an online Alexander-based training program for people with Parkinson's disease and their care partners.

Six dyads, each consisting of a person with Parkinson's disease and their care partner, will participate in a real-time online course called "Poised for Parkinson's." The course will meet twice per week via Zoom for eighteen 105-minute sessions. Outcome measures, including surveys, interviews, balance, and motor performance, will be assessed the week before classes begin and the week after classes end.

Eligibility Criteria:
Inclusion Criteria:

* dyad including care partner and person with Parkinson's disease
* Hoehn \& Yahr Stage 2 (estimated)
* vision and hearing (corrected to) normal
* able to use computer, Internet, and Zoom
* ambulatory without assistive devices
* reside in Idaho

Exclusion Criteria:

* dementia (screen with MOCA)
* severe musculoskeletal pain (screen in interview)
Long Term Follow-Up of Burn Injuries

The purpose of the study is to investigate the psychological effects of burn injuries as experienced by patients.

We are interested in determining how people adjust to burn injuries as a way of facilitating optimal recovery. This is done by conducting several questionnaires at the time of the discharge in the hospital, and later follow up with the patients up to two years.

Eligibility Criteria:
Inclusion Criteria:

* patients with more than a 30% total surface area burn
* English speaking

Exclusion Criteria:

* Patients with less than a 30% total surface area burn
* Non English speaking
Multicentre Observational Study on Management COVID 19 Positive Outpatients in a French Cluster.

Since December 2019, a new agent, the coronavirus SARS-Cov-2, has spread from China to the rest of the world causing an international epidemic of respiratory diseases called COVID-19. Oise was one of the first clusters in France, with more than 4,000 confirmed cases. A significant proportion (80%) of patients with COVID-19 are ambulatory. However, few data are available for this particular population in France. Thus, few clear recommendations are available.

We propose to conduct a large cohort of observation of suspected or confirmed COVID-19 patients on an ambulatory basis in the Oise region. This observatory will make it possible to describe the epidemiological characteristics and initial management of COVID-19 patients and to identify early severity factors.


Eligibility Criteria:
Inclusion Criteria:

* patients with covid 19 symptoms
* patients who had a contact with a person PCR Covid 19+

Exclusion Criteria:

* none