cyrilzakka/clinical-trials huggingface dataset:
Feasibility of AI-based Heart Function Prediction Model Using CXR

The investigators will develop an artificial intelligence model to predict left ventricular ejection fraction using chest radiographic images and transthoracic echocardiography data.

Echocardiography should be considered at an early stage in patients who have first developed heart failure or who do not have information about heart function, but the examination may be delayed due to lack of time and manpower in the actual medical field.

Primary Objective: Use chest radiographs to predict the left ventricular ejection fraction

Eligibility Criteria:
Inclusion Criteria:

* Adults who are 20 years and older
* Patient who visited the emergency room or outpatient clinic due to dyspnea and chest pain

Exclusion Criteria:

* Patient refusal
* Uncertain radiographs or transthoracic echocardiography
* Uncertain tests results
Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients with Cancer

The goal of this research study is to understand the effect of inhalation approaches in reducing nausea in cancer patients.

In this study, inhalation of a study solution will be compared to inhalation of placebo, both in the form of preparation pads (a small square of material that contains the solution). Isopropyl alcohol may be a part of the preparation pads. A placebo is not a drug. It looks like the study solution but is not designed to treat any disease or illness. It is designed to be compared with the study solution to learn if the study solution has any real effect.

Inhalation of the study solution may help to control your nausea. Future patients may benefit from what is learned. There may be no benefits for you in this study.

Your participation is completely voluntary. Before choosing to take part in this study, you should discuss with the study team any concerns you may have, including side effects, potential expenses, and time commitment.

Eligibility Criteria:
Inclusion Criteria:

* Rate current severity of acute/chronic nausea \>= 4 on NRS (Numeric Rating Scale)
* Diagnosis of cancer
* Able to read/write in English
* Referred to supportive care service as an inpatient or outpatient
* Rate anxiety as =\< 4 on ESAS-FS (Edmonton Symptom Assessment Scale-Financial Distress and Spiritual Pain)
* Participants must agree to inhale isopropyl alcohol

Exclusion Criteria:

* Received anti-emetics in the last 30 minutes
* Received medical procedures (e.g. blood draws) which required exposure of isopropyl alcohol in the last 30 minutes
* Inability to inhale through nares (including recent upper respiratory infection)
* Known allergy to isopropyl alcohol
* Delirium (i.e., score \>= 7 on the Memorial Delirium Assessment Scale \[MDAS\])
* Have never been on anti-emetics during the course of the treatment here (anti-emetic naive)
Factors Association With Poor Physical Function in Older Adults With Schizophrenia

Older adults with schizophrenia are a growing segment of the population yet their physical health status is poor. In order to design effective interventions, the contributing factors must be understood. Current data suggest the side effects of psychiatric medications, sociodemographic factors, and health care disparities are a few of the reasons for the poor physical health. There are only limited data on the impact of psychiatric symptomatology and neurocognition on the physical health of this population. These limited data indicate that worse symptomatology and poorer neurocognition may negatively impact physical functioning, a critical component to optimal physical health. The purpose of this pilot study is to begin to fill this knowledge gap by: 1. examining the relationship between neurocognitive function and physical function and 2. Examining the relationship between schizophrenia symptoms and physical function. 3. Examining the relationship between serum Brain Derived Neurotrophic Factor (BDNF) and physical function. Using a descriptive correlational design, 50 older adults (55+) with schizophrenia or schizoaffective disorder will be assessed. Bivariate associations will be used to examine the relationship between key variables including schizophrenia symptoms as measured by the Positive and Negative Syndrome Scale (PANSS), neurocognitive function as measured with the MATRICS Consensus Cognitive Battery (MCCB), Physical Function as measured objectively by the Timed Get Up and Go (TGUG) test and subjectively with the physical component summary subscale of the 12-item short form health survey (SF-12), and serum BDNF. These pilot data will lay the foundation for a future health promoting intervention.


Eligibility Criteria:
Inclusion Criteria:

* English speaking adults older than or equal to 55 with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder that pass a capacity to consent test based on comprehension of the consent form.

Exclusion Criteria:

* Non-English speaking,
* Adults younger than 55,
* No diagnosis of schizophrenia of schizoaffective disorder, and/or
* Not passing a capacity to consent test.
Efficacy of Self-titration of Ventilation in Overlap Syndrome (chronic Obstructive Pulmonar Disease + Sleep Apnea Syndrome ) with Dynamic Hyperinflation. EDIN-IDIN.

The combination of COPD and obstructive sleep apnea (OSA) can lead to undesirable interactions with the treatment approach. The investigators know that continuous positive airway pressure (CPAP) can increase dynamic hyperinflation in COPD patients, and in mechanical ventilation, the increase in PEEP can worsen dynamic hyperinflation. On the other hand, the team know that the severity of COPD obstruction and hyperinflation alter sleep efficiency, with periods of wakefulness during sleep, and during these periods, the patient would not have upper airway obstruction, which could affect the therapy they are receiving in CPAP mode for OSA. Moreover, it was observed that with greater hyperinflation, the rate of obstructive events decreases, dynamically affecting the ventilatory situation with upper airway resistance. Recent studies have determined the safety and efficacy of auto-adjusting systems in the treatment of overlap syndrome, which could be more adaptable to the changing pulmonary mechanics of these patients. Aerobic capacity is a good predictor to the health status in these patients and the investigators know it is reduced in patients with AOS, where CPAP treatment according to studies improves the peak VO2. Therefore, the objective is to compare a ventilation system with fixed pressures established through polysomnography in patients with overlap syndrome and dynamic hyperinflation to a dynamic ventilation system using the fixed pressure limits typically established, based on their impact on the aerobic capacity (peak VO2) of these patients after 1 month of treatment.


Eligibility Criteria:
Inclusion Criteria:

* Stability of at least 4 weeks without hospital admission.
* Previously presented PCO2 \> 52.
* Age between 50 and 80 years.
* Agree to participate in the study and sign the informed consent.
* Both sexes.

Exclusion Criteria:

* Refusal to participate in the study.
* Uncontrolled structural or coronary heart disease (no changes in medication in the last 15 days).
* LVEF \< 45%.
* Central sleep apnea syndrome (≥ 50% central events).
* Uncontrolled pulmonary hypertension.
* Inability to perform the tests.
* Having had an exacerbation 4 weeks prior.
* Severe psychiatric illness.
* Cognitive impairment.
* Not speaking Spanish.
* Illiteracy.
* Active smoker (or \< 6 months since quitting smoking).
Efficacy and Mechanisms of TUS on Cognitive Deficits in Schizophrenia: Based on the Hippocampal-Prefrontal Circuit

Cognitive deficit is a core symptom of schizophrenia related to poorer functional outcome. Prior studies indicated that abnormalities in the hippocampus-prefrontal circuit and glutamate/GABA imbalances may lead to cognitive deficits. Based on the current background and our previous studies, it has been proved that TUS can modulate neural excitability and plasticity in the hippocampus. In this double-blind, randomized study, the efficacy of different treatment options and mechanisms of TUS on cognitive deficits will be investigated.

Cognitive deficit is a core symptom of schizophrenia related to poorer functional outcome which remains largely treatment refractory. Prior studies indicated that abnormalities in the hippocampus-prefrontal circuit and glutamate/GABA imbalances may be the root causes of cognitive deficits. Transcranial ultrasound stimulation (TUS), an emerging non-invasive neuromodulation technique with deep penetration ability, can modulate neural excitability and plasticity in the hippocampus. This is a 4-week double-blind randomized trial of TUS for cognitive deficits in schizophrenia, with either left hippocampus or left dorsolateral prefrontal cortex (DLPFC) or both targeted. This study aims to determine the efficacy of TUS and to reveal its underlying neural mechanism, especially with the hippocampus-prefrontal circuit, by means of TUS, as to assess cortical inhibition and excitability, EEG source imaging, and multi-model MRI. Neuropsychological assessments will also be conducted to develop the optimized treatment strategy. The study points to a novel and promising therapeutic neuromodulation approach that may improve the functional outcome of schizophrenia, which has been the main cause of mental disability.

Eligibility Criteria:
Inclusion Criteria:

* Meet the DSM-5 diagnostic criteria for schizophrenia ;
* Age18-50, right-handed, Han nationality;
* Presence of cognitive deficit: defined as d' value \<0.5 in associative memory test;
* Be in a stable condition, received second-generation antipsychotics for at least 4 weeks or more;
* Written informed consent;

Exclusion Criteria:

* Current or past neurological illness, severe physical diseases, substance abuse or alcohol dependence, mental retardation, pregnancy or lactation;
* Uncooperative or risky patients with high excitement, stupor, disorder of words and deeds, negative suicide, etc.;
* History of MECT or other physical therapy within 6 months;
* History of epilepsy, or epileptic waves on the baseline EEG;
* Ruled out share antiepileptic drugs (carbamazepine, valproic acid salt) or larger doses of benzodiazepine drugs (diazepam \> 10mg/day, clonazepam \> 2mg/day etc.), if necessary, remain unchanged during the course of treatment;
* Contraindications to TUS and MRI are present.
Pulmonary Recruitment Maneuver for Postlaparoscopic Shoulder Pain

The aim of this clinical trial is to evaluate the efficacy and safety of different recruitment maneuvers for reducing postlaparoscopic shoulder pain.

Shoulder pain after laparoscopy is common and its probable mechanism is residual CO2 gas after surgery. The pulmonary recruitment maneuver can mechanically remove residual CO2 and reduce pain. In literature, there are two different recruitment maneuvers, which was manual inflation of the lungs with positive pressure ventilation of either 40cmH2O or 60cmH2O at the end of surgery. However, the higher positive pressure may be associated with more chance of barotrauma. Therefore, it is important to determine the lowest effective pressure for reducing postlaparoscopic shoulder pain. The aim of this clinical trial is to evaluate the efficacy and safety of different recruitment maneuvers (40cmH2O or 60cmH2O) for reducing postlaparoscopic shoulder pain.

Eligibility Criteria:
Inclusion Criteria:

* patients undergoing laparoscopy for benign gynecologic diseases
* patients aged 19-65 years
* patients with american society of anesthesiology physical status I-II
* patients obtaining written informed consent

Exclusion Criteria:

* patients with chronic shoulder pain, chronic epigastric pain or chronic pain syndrome
* patients with past history of pneumothorax or any pulmonary surgical history
* patients with any shoulder surgery histories
* patients who required to conversion to open surgery from laparoscopic surgery
* patients who required to receive incidental upper abdominal surgeries due to adhesion and injury at upper abdominal cavity
* patients with inability to understand or express 10 point visual analogue scale
* intrauterine pregnant women
Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk

The study is to compare the prophylactic and therapeutic clinical effectiveness of two fluoride varnishes in children at high caries risk.

It was hypothesized, the use of Fluor Protector S (I) fluoride varnish in children with deciduous teeth at high risk of caries (P) reduces caries and the activity/remineralisation of carious enamel spots (transformation of White Spot Lesion into D (decay)) (O), similarly to what occurs after the use of Duraphat varnish (C).

The study is to compare the prophylactic and therapeutic clinical effectiveness of two fluoride varnishes in children at high caries risk.

It was hypothesized, the use of Fluor Protector S (I) fluoride varnish in children with deciduous teeth at high risk of caries (P) reduces caries and the activity/remineralisation of carious enamel spots (transformation of White Spot Lesion into D (decay)) (O), similarly to what occurs after the use of Duraphat varnish (C).

The question set bases on a Caries Assessment by Risk Management system basing on the occurrence of major caries causative agents (biological and medical), and also of the protective/preventive ones. Questions related to the social and economical status will be left out because of the difficulty of getting them answered honestly. Teeth will be scored according to International Caries Detection System II classification, and oral hygiene according to the Greene and Vermillion simplified Oral Hygiene Index (OHI-S) (1964). Children and their parents/guardians will receive hygienic, dietary and prophylactic guidelines.

Eligibility Criteria:
Inclusion Criteria:

* generally healthy children aged 3-5 years
* high risk of caries
* parent/legal guardian consent for participation in research study

Exclusion Criteria:

* chronic diseases or medication in medical history
* planned change of residence within a year
* aged \<3, \>5 years
In Vitro Exposure by VR to Enhance Return to Work After Sick Leave Due to Stress-related Complaints

The goal of this pilot randomised controlled trial is to investigate whether in vitro exposure by VR enhances return to work (RTW) in flight cabin crew on sick leave with stress-related complaints. The main research questions are: 1. Does VR enhances time to full RTW? 2. Does VR increase self-efficacy and positive cognitions regarding RTW, and decrease job anxiety? Researchers will compare a control group receiving care as usual as provided by a psychotherapist to an intervention group receiving care as usual plus one session with VR-glasses in which participants are virtually exposed to their workplace.

This study evaluates the effectiveness of in vitro exposure to the workplace by means of VR to improve sustainable RTW among sick-listed flight cabin crew with stress-related complaints compared to usual care. The study design is a pilot randomized controlled trial, including an intervention and control group. Sick-listed workers in the control group receive care as usual from a psychotherapist. Sick-listed workers in the intervention group receive care as usual from a psychotherapist and participate in a VR-session. During the VR-session, guided by the psychotherapist, participants are virtually exposed to their workplace. Data on the primary outcome of (full) RTW is collected based on the company's register data (12 months after baseline). Data on secondary outcomes (self-efficacy, cognitions regarding RTW and job anxiety) is collected with baseline and follow-up questionnaires (4 months after baseline).

Eligibility Criteria:
Inclusion Criteria:

- sick listed cabin crew with stress-related complaints that are referred by the occupational physician to a specific psychotherapist practice

Exclusion Criteria:

* epilepsy
* eye condition
* no signed informed consent
Frailty Index and Geriatric Assessment in Predicting Toxicity to Front-Line Chemotherapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer

This phase II trial is studying how well a frailty index and geriatric assessment works in predicting toxicity to front-line chemotherapy in treating patients with stage IV non-small cell lung cancer. A frailty index and geriatric assessment prior to treatment may help identify a better treatment regimen

PRIMARY OBJECTIVE:

I. To determine the correlation of the data from the frailty index and geriatric assessment tool with the level of toxicity encountered in the first two cycles of therapy.

OUTLINE:

Patients complete a frailty index and geriatric assessment prior to beginning chemotherapy. Patients receive standard-of-care chemotherapy comprising carboplatin intravenously (IV) and paclitaxel IV on day 1. Treatment repeats every 21 days for up to 2 courses.

Eligibility Criteria:
Inclusion Criteria:

Pathological documentation of non-small cell lung cancer Stage IV disease Prior adjuvant chemotherapy for the earlier stages of non-small cell lung cancer is allowed Patients with brain metastases are allowed on protocol only if they have received brain irradiation and are neurologically stable Patients with other malignancies are allowed on protocol unless they are receiving active treatment (surgery, radiation, chemotherapy or immunotherapy) for the other malignancy Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

Prior palliative chemotherapy Pregnant and/or lactating women Prior radiation therapy other than brain irradiation for brain metastases
Microvascular Reactivity in Prepubertal Children

This is a cross-sectional study aimed to investigate microvascular reactivity in prepubertal children according to adiposity status.

The investigators aimed to investigate microvascular reactivity in prepubertal and to compare these data in different groups according to adiposity status. Firstly, The investigators recruited only children from 5 to 10 years at prepubertal status. After excluding those with exclusion criteria and the acceptance (from their parents) to participate in the study, a blood sample was collected and an appointment at BioVasc lab was programmed. At this day, participants were subject to nail fold videocapillaroscopy. A method used to investigate microvascular reactivity by a non-invasive mean. After this, participants children were followed to the outpatient's care unit to continue follow-up.

Eligibility Criteria:
Inclusion Criteria:

children aged from 5 to 10 years at prepubertal Tanner´s status

Exclusion Criteria:

* puberty
* regular use of any medication
* hypertension
* heart disease
* renal and blood diseases .the presence of any acute or chronic inflammatory/infectious diseases. .presence of diabetes mellitus.
A Pilot Randomized Trial of a Comprehensive Transitional Care Program for Colorectal Cancer Patients

The primary hypothesis is that a comprehensive transitional care program based on the premise of a patient-centered medical home versus routine care reduces emergency room visits and hospital readmissions without increasing costs among cancer patients undergoing surgery at a large safety-net hospital.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of colorectal cancer
* Adults, Age 18 years or older
* Undergoing surgery for either palliative cure or palliation

Exclusion Criteria:

* Patients not expected to survive hospital based on the operating surgeon's opinion
* Children under the age of 18 years
A Study of ADR-001 in Patients With Liver Cirrhosis

This is a first-in-human Phase1/2 study of ADR-001, adipose-derived mesenchymal stem cells (AD-MSCs). The safety and preliminary efficacy are evaluated in Phase 1 in patients with liver cirrhosis caused by Hepatitis C or Nonalcoholic Steatohepatitis and a recommended Phase 2 dose is determined by the evaluation. The exploratory efficacy and safety are investigated against the same target population in Phase 2.

Patients with decompensated liver cirrhosis (Child-Pugh score; Grade B) caused by Hepatitis C or Nonalcoholic Steatohepatitis are enrolled to the study. In Phase 1, one of 3 doses of AD-MSCs is administered by 1 hour single intravenous infusion. Patients are hospitalized for 1 week and a recommended dose for Phase 2 is determined by the evaluation of the safety and efficacy. In Phase 2, patients with the same disease criteria are enrolled and dosed to investigate the exploratory efficacy and safety.

The safety and efficacy are evaluated until 24 weeks after dosing both in Phase 1 and Phase 2.

Eligibility Criteria:
Inclusion Criteria:

* Men and women ≥ 20 years of age
* Chronic hepatitis C or nonalcoholic steatohepatitis(NASH)
* Child-Pugh grade B liver cirrhosis
* ECOG Performance Status ≤ 2

Exclusion Criteria:

* Liver cirrhosis patients other than hepatitis C or NASH
* Malignant neoplasm (except hepatocellular carcinoma patients without recurrence more than 2 years)
* History of venous thrombosis or pulmonary embolism
* Serum creatinine ≥ 2 mg/dL or T-Bil ≥ 5.0 mg/dL
* Infection with hepatitis B, HIV, ATLV-1 or parvovirus B19
* Patients experienced transplantation or cell therapy
* Pregnancy or positive on pregnancy test
* Complications of significant heart disease, kidney disorder, or respiratory disease
* Drug or alcohol abuse
Management of Post-circumcision Ischemia Using Hyperbaric Oxygen Therapy

Background: Post-circumcision penile ischaemia is a rare but destructive complication. Our goal is to present our experience in the management of children, who had different forms of penile ischaemia, complicating the routine ritual male circumcision.

Material and Methods: All male children who had post-circumcision penile ischaemia between April 2017 and October 2020 were included in the study. A special designed protocol for management of all cases includes a combination of early Pentoxifylline intervenes infusion with Hyperbaric Oxygen inhalation, early catheterization, and appropriate surgical debridement. Data were analyzed inclusively to patient age, the anesthesia method used, Monopolar diathermy usage, early presentation, method of circumcision and positive wound culture.

It is a cohort prospective study. All male children who had penile ischaemia after circumcision were included in the study between April 2017 and October 2020. A special designed protocol includes early admission of a child in Paediatric intensive care unit (PICU). Catheterization by suitable size silicon Foley's catheter appropriate for the age. IV Pentoxifylline in a dose of 10 mg/kg/day divided into 3 equal doses with good monitoring of its side effects mainly tachycardia and convulsions. IV 3rd generation cephalosporin with suitable doses according to the age and body weight. Hyperbaric Oxygen therapy is a specially designed cabinet for infants and neonates with a barometric pressure equal to 760 mmHg for 20 minutes daily, then gradually increase up to one hour daily for 5 days per week (fig. 1). The chamber was kept warm. The babies were fed before entering the chamber and if signs of hunger appear during therapy. The baby was continuously monitored with pulse oximeter. Older children are managed in the conventional Hyperbaric Oxygen chamber with the same regimen. Proper surgical debridement together with daily topic dressing with nitroglycerin ointment (2%). The treatment continued through the admission period. Follow up period range from 6 months up to 3 years.

Data were analyzed inclusively to patient age, the type of medical provider who performed the circumcision, the technique of male circumcision, the anesthesia method used, if any Monopolar diathermy usage, wound suturing after MC, the duration of between male circumcision and presentation to our protocol, and the final condition of the patient at discharge and after 6 months.

Eligibility Criteria:
Inclusion Criteria:

- male children complained of penile ischaemia after circumcision.

Exclusion Criteria:

* other post-circumcision complication not include penile ischaemia
* patients with chronic diseases.