cyrilzakka/clinical-trials huggingface dataset:
Comparison of Bone Microarchitecture Analysed by HRpQCT and pQCT in Pathologies With Bone Loss and/or Muscle Loss

The study aims to utilize medical devices, such as the Xtreme CT and XCT 3000, to assess bone and muscle microarchitecture for various pathologies. The devices provide crucial data on bone and muscle density, aiding in understanding fracture risks associated with conditions like rheumatoid arthritis and neurological disorders. Current methods like DXA scanning have limitations in predicting fracture risks accurately due to their inability to assess cortical and trabecular microstructure. The study emphasizes the importance of evaluating cortical porosity and trabecular volume loss, especially in conditions like post-menopausal osteoporosis and sarcopenia. Additionally, it explores the impact of neurological disorders, renal insufficiency, and endocrinopathies on bone health. Furthermore, the study aims to establish a control group to differentiate pathological changes from age-related variations. Expected outcomes include a comprehensive understanding of bone microarchitecture alterations across various pathologies and the potential to improve fracture risk estimation beyond conventional methods like DEXA scanning. Ultimately, the study anticipates facilitating better management strategies to reduce fracture risks associated with these conditions.


Eligibility Criteria:
Inclusion Criteria:

For the patients:

Women or men treated at the Saint-Etienne University Hospital and presenting an osteoporotic risk with one of the following associated pathologies:

* Osteoporosis defined by: History of a documented brittle bone fracture
* Bone fragility: Patient with indication for bone densitometry but no history of fracture
* Inflammatory joint disease:

  * Rheumatoid arthritis
  * Spondyloarthritis
* Chronic kidney disease
* Endocrinopathies:

  * Primary hyperparathyroidism
  * Constitutional thinness
  * Anorexia nervosa
  * Obesity (BMI \>30)
  * Sarcopenia
* Neuropathies - Parkinson's disease

For the controls:

Acute episode of spinal or radiculalgia (less than one month old) with corticosteroid treatment of less than 1 month Signature of written consent

Exclusion Criteria:

* No sign written consent

For the controls:

* Medications inducing bone loss:
* anti-aromasin or GnRH agonist for at least 6 months,
* corticosteroids (dose ≥ 5 mg/d for 6 months)
* anti-epileptic drugs: carbamazepine, phenobarbital, phenytoin, primidone, valproic acid for at least 6 months)
* History of fracture due to bone fragility
* Taking bone-targeting medication (biphosphonate, teriparatide, strontium ranelate)
Establishing First Trimester Markers for the Identification of High Risk Twin

The purpose of this study is to determine whether we can establish different markers suc as mean arterial pressure , flow in the uterine arteries, biochemical markers in maternal blood and more un the first trimester, in order to screen for twin pregnancies that are more likely to develop adverse pregnancy outcome: early delivery, pre eclampsia or small fetuses.


Eligibility Criteria:
Inclusion Criteria:

* pregnant women from 11 -14 weeks of gestation

Exclusion Criteria:

* nuchal thickness above 3 mm,
* Chronic hypertension,
* thrombophilia,
* Diabetes
A Study to Compare FCD105 Foam to Minocycline 3% Foam, Adapalene 0.3% Foam and Vehicle Foam.

A study comparing FCD105 to 3% minocycline foam, 0.3% adapalene foam and vehicle foam in patients ≥ 12 years old for the treatment of moderate-to-severe acne.


Eligibility Criteria:
Inclusion Criteria:

1. Has facial acne vulgaris with all of the following:

   1. 20 to 50 inflammatory lesions (papules and/or pustules) on the face.
   2. 25 to 100 non-inflammatory lesions (open and closed comedones) on the face.
   3. IGA score of moderate (3) to severe (4).
2. No more than two active nodules on the face.
3. Willing to use only the supplied non-medicated cleanser and to refrain from use of any other acne medication, medicated cleanser, excessive sun exposure, and tanning booths for the duration of the study

Exclusion Criteria:

1. Female who is pregnant or lactating, or is planning a pregnancy during the study.
2. Acne conglobata, acne fulminans, secondary acne (chloracne, drug-induced acne), or any dermatological condition of the face that could interfere with the clinical evaluations.
3. Facial hair (eg, beard, mustache, etc.) that could interfere with the clinical evaluations.
4. Sunburn on the face.
5. Severe systemic disease as assessed by the Investigator that might interfere with the conduct of the study or the interpretation of the results.
6. Subjects who have a documented history of any of the following:

   1. Allergy to tetracycline-class antibiotics or to any ingredient in the study drug.
   2. Pseudomembranous colitis or antibiotic-associated colitis.
   3. Hepatitis or clinically significant liver damage or clinically significant renal impairment.
   4. Known or suspected premalignant or malignant disease (excluding successfully treated skin cancers).
7. Subjects who have used the following medications:

   Within 1 week prior to randomization:
   * Medicated facial cleansers on the face.
   * Topical acne treatments on the face (other than those listed below).

   Within 4 weeks prior to randomization:
   * Topical retinoids on the face.
   * Topical anti-inflammatories and/or corticosteroids on the face.
   * Topical corticosteroids on body areas other than the face for more than 15 consecutive days and on more than 10% of the body surface area. In body folds, such as axillary and inguinal regions, only mild topical steroids are allowed for short term use (≤15 consecutive days).
   * Systemic antibiotics.
   * Systemic acne treatments.

   Within 12 weeks prior to randomization:
   * Systemic retinoids.
   * Systemic corticosteroids (Note: Intranasal and inhaled corticosteroids may be used throughout the study if the subject is on a stable dose).
8. Use of sauna during the 2 weeks prior to randomization.
9. Epilation of the face within 2 weeks prior to randomization.
10. Folliculitis on the face.
11. Documented history of depression that is not, in the opinion of the Investigator, currently adequately controlled with medication
Effects of Analgesics in Cesarean Section Elective

Two approved treatments for spinal anesthesia will be compared in women undergoing cesarean section.

It is usual to perform cesarean sections using spinal anesthesia with a local anesthetic (bupivacaine) plus some opioid, such as sufentanil or morphine. Both have been shown to decrease postoperative pain, but we try to check if one brings more benefit than the other.


Eligibility Criteria:
Inclusion Criteria:

* Patients of at least 18 years.
* Patients at least 36 weeks gestation.
* Patients scheduled for non-urgent cesarean section.
* Patients classified in the physical state of the American Society of Anesthesiologists (ASA) as grade I-II, and without important fetal pathological conditions.
* Signature of informed consent that allows them to be part of the study.

Exclusion Criteria:

* Pregnant women who reject the spinal technique.
* Patients with contraindication to spinal anesthesia.
* Patients with ASA\> II classification.
* Patients with multiple pregnancy.
* Patients with three or more previous cesareans,
* Patients with BMI greater than or equal to 40 kg / m2.
* Language barrier.
* Patients with pre-eclampsia.
* Patients with a history of chronic pain.
* Patients with a history of psychiatric or drug abuse.
* Patients with allergy to any of the drugs used in the study.
Comparison of DHT Duration in Geriatric Patients Using BIS Monitoring

Without adequate monitoring, administration of anesthetic agents can create unnecessary deeper anesthetic plane in geriatric population. This study aims to compare the duration of deep hypnotic time (DHT) in geriatric patients undergoing general anesthesia with additional BIS monitor compared to standard monitoring. This study was a randomized clinical trial involving 44 geriatric patients undergoing general anesthesia. Subjects are divided into two groups, one with additional BISTM monitor and the other with standard monitoring. Data acquired from BISTM will continually be recorded to be analyzed afterward


Eligibility Criteria:
Inclusion Criteria:

* Sampling was consecutively conducted on geriatric patients aged \>60 years undergoing general anesthesia for procedures lasting \>2 hours with ASA physical status 1-3 and willing to participate in the study

Exclusion Criteria:

* Exclusion criteria included intracranial procedures, unstable hemodynamic conditions, neurocognitive impairment, and if the patient was anticipated not to be extubated at the end of the surgical procedure. Patients could be excluded if the preoperative MMSE score was \<24, undergoing general anesthesia using a combination of ketamine and/or N20 agents, experiencing emergencies during surgery, and losing BIS data \>10% of the duration of the operation
Impact of Cancer Treatment on the Pelvic Floor Function in Survivors of Cervical Cancer

Introduction: Pelvic floor muscle dysfunctions (PFMD) represent an important public health problem that manifests itself through lower urinary tract symptoms (LUTS), anorectal and sexual dysfunction. PFMD is a common problem in cervical cancer survivors (CC) with a negative impact on quality of life (QoL). Objective: This study aims to evaluate the effect of oncological treatment on the function of pelvic floor muscles (PFM) of survivors of CC. Methods: Patients diagnosed with CC, of any stage, histology and degree, accompanied by the Oncology Gynecology Service of the Hospital das Clínicas of the Medical School of Ribeirão Preto at the University of São Paulo, will be studied in the period between 2004 and 2014. Four study groups will be formed: (1) Patients with CC with PFMD; (2) Patients with CC without PFMD; : (3) Patients without CC with PFMD; (2) Patients without CC without PFMD. Non-cancer patients will be recruited into the community. For the analysis of the prevalence of PFMD will be applied to the discomfort Questionnaire on pelvic floor (IDPE-20) for evaluation of pelvic organ prolapse (POP) complaints, anorectal symptoms and urinary incontinence, and the Sexual Questionnaire for urinary incontinence and pelvic organ prolapse (PISQ -12) for evaluation of sexual function. Both questionnaires have already been validated for the Portuguese language and are specific for women with PFMD. The pelvic floor impact questionnaire (PFIQ-7) will also be applied to assess the impact of PFMD on quality of life, daily living activities and emotional health. For the evaluation of general QOL, the EORTC questionnaire QLQ-C30 and its specific module for patients with CC, QLQ-CX24 will be used. The evaluation of PFM function will include vaginal palpation (Modified Oxford Scale) and perineometry (Peritron).


Eligibility Criteria:
Inclusion Criteria:

* Women diagnosed with CC; No distinction as to age, race, scholarity and religion; Women in follow-up at Clinical Hospital of Medical School of Ribeirão Preto of University São Paulo.

Exclusion Criteria:

* Women who did not complete the proposed cancer treatment; Women who presented CC as the second malignant neoplasm; Pregnant women; Failure to respond to the proposed questionnaires.
Transfer and Ultrafiltration In Peritoneal Dialysis

The aim of this study is to demonstrate the efficiency of an adapted and "alternate" peritoneal dialysis scheme in terms of sodium extraction and purification compared to an adapted conventional peritoneal dialysis scheme.


Eligibility Criteria:
Inclusion Criteria:

* Patients hospitalized in the Nephrology department of the Besançon University Hospital
* Patients treated by continuous ambulatory peritoneal dialysis or ambulatory peritoneal dialysis for at least 6 months
* Absence of hospitalization caused by an infection in the month prior to inclusion
* Patients with a ratio (D / P) of the concentration of creatinine in the blood and dialysate between 0.5 and 0.8 on a checkup of less than 1 year.
* No contraindication to the use of hypertonic bag
* Signature of informed consent for participation indicating that the subject has understood the purpose and procedures required by the study and agrees to participate in the study and comply with the requirements and limitations inherent in this study
* Affiliation to a French social security system or beneficiary

Exclusion Criteria:

* Legal incapacity or limited legal capacity
* Patients unlikely to cooperate in the study and/or low cooperation anticipated by the investigator
* Patients without health insurance
* Pregnant women
* Patient being in the exclusion period from another study or planned by the "national register of volunteers"
* Hospitalization caused by an infection in the month prior to inclusion
* Patients with a peritoneal dialysis catheter dysfunction
Early Development and Diagnostic Trajectories in DCD

The aim of this study is to map the early development of children with DCD and the diagnostic trajectory in Flanders.

The Diagnostic and Statistical manual 5th edition (DSM-V) defines Developmental Coordination Disorder (DCD) as early-onset deficits in acquiring and executing motor coordination skills. These deficits significantly interfere with the performance of activities of daily living and impact on academic productivity, leisure and play.

Although DCD can be identified during preschool, diagnosis generally occurs at primary-school age. Before the age of three (t.i. infancy), some parents already express "something is wrong" with their child albeit DCD is rarely diagnosed within this age-group.

Knowledge on DCD in children before the age of five is limited. The aim of this study is twofold: to explore the early development of children with DCD and to map the diagnostic trajectory of DCD in Flanders.

Design: A qualitative narrative inductive study design by means of audio-recorded in-depth interviews

Sampling: Purposeful maximum variation sampling will be applied.

Eligibility Criteria:
Inclusion Criteria:

1. Parent or guardian of a child diagnosed with DCD
2. Diagnosis of DCD within the last two years
3. Child was max. 12y of age at the moment of DCD diagnosis

Exclusion Criteria:

1. No severe diseases in early childhood greatly impacting development (cancer, severe accident,...)
2. Diagnosis outside of Belgium
Effects and Perception of Intensive Virtual Reality Training on Upper Limb Functions After Stroke

Previous literature review shows limited work on upper limb recovery from Virtual Reality device and most of them are pilot studies meta-analysis some Randomized control Trial studies are done but this study will cover mixed method including both qualitative and quantitative method.

Stroke is the leading cause of disability worldwide Approximately 80% of stroke survivors regain ability to walk, 30 - 66% of survivors are not able to use their affected upper limb mobility. With improving survival rates and longer life expectancy in general, the burden of caring for stroke survivors is likely to increase. As a lack of upper limb recovery results in significant dependence and a reduced quality of life. Persistent upper limb (UL) dysfunction after a stroke is one of the most challenging issues in rehabilitation. Effective upper limb treatment interventions have therefore been identified as a priority for stroke research. One of the rehabilitation strategies include performing self-administered exercises using VR games technology. Effective treatment interventions post-stroke is characterized by high intensity and repetitive practice of a meaningful task. However, changes in infrastructure, an emphasis on mobility during early rehabilitation ,to reduce hospital length of stay and a lack of therapy on discharge home have resulted in challenges delivering the amount of rehabilitation necessary to optimize recovery. A promising technique, which has the capability of creating an interactive environment in which practice intensity and feedback can be manipulated to retrain movement in the upper limb in people with stroke, is virtual reality (VR) technology .VR provides a sense of illusion: of being immersed in a world where objects can he visualized and interact with. The system is usually a controlled one, where the objects and interaction styles (point, touch, grasp) are defined prior to the controlling program being executed. There are a number of ways in which the virtual environment (VE) can he presented to the user. Most common are desktop (fish tank) VR systems where the VE is displayed on a standard desktop monitor. The user can interact with the environment via standard hardware (keyboard, mouse) or via specialized VR devices such as data gloves, hut is conscious of 'looking at' the environment rather than 'immersed in' the environment.

Eligibility Criteria:
Inclusion Criteria:

1- Subacute and chronic stroke patient \> 3 months post stroke till 1 year. 2. Both gender 3. Age: 40-70 years 4. Modified Ashworth scale1-3 5. MMSE\>25 6. Able to follow verbal instructions related to the use of VR devices

Exclusion Criteria:

1. Neurological disorders other than stroke.
2. Aphasia that would limit the ability to follow verbal instructions.
3. Participation in other upper extremity therapies during the study
Effects of Kinesio Taping in Addition to Routine Physical Therapy on Pain, Range of Motion and Functional Disability in Patients With Upper Cross Syndrome

Objective of the study is to compare the effects of kinesio taping and routine physical therapy on pain, range of motion and functional disability in patients with upper cross syndrome.It is a single blinded randomized controlled trial using non probability purposive sampling technique.

ALTERNATIVE HYPOTHESIS:

There is a significant difference in the effects of routine physical therapy with and without kinesio taping on pain, range of motion and functional disability in patients with upper cross syndrome.

NULL HYPOTHESIS:

There is no significant difference in the effects of routine physical therapy with and without kinesio taping on pain, range of motion and functional disability in patients with upper cross syndrome.

It will be a prospectively registered ,parallel designed, randomized controlled trial with concealed allocation. Subjects will be selected from the outpatient Department of Physical Therapy, The University of Lahore Teaching Hospital,Lahore, Pakistan. Patients who met eligibility criteria will be informed about the aim of study.all the eligible participants who will agree to participate will sign a consent form. After baseline assessment selected participants will be divided into 2 groups by random allocation method.Subjects will be randomized into two groups using computer generated random numbers.The outcome assessor will be unaware of treatment given to both groups.The calculated sample size using Numeric pain rating scale as outcome measure is 28 in each group, but after adding 20% dropout, the sample size will be 28+6=34 in each group, allowing statistical power of 80%and alpha level of 5%.

Eligibility Criteria:
Inclusion Criteria:

* Both gender
* Participants with an age between 18 to 40
* Participants diagnosed with chronic upper cross syndrome by orthopedic department for physical therapy treatment

Exclusion Criteria:

* Trauma, Tumor and Fracture of upper limb and shoulder
* Congenital deformities of upper limb
* History of any systemic disease
* History of any neurological disease (epilepsy \&amp;seizure, Parkinson's disease)
* History of recent surgery of spine or shoulder
Prevalence and Recognition of Geriatric Syndrome in Outpatient Clinic at Srinagarind Hospital

The purpose of this study is to collect the prevalence of geriatric syndrome, which is recognized by an internist, and to compare the data based on the comprehensive geriatric assessment by a geriatrician. The secondary outcome is to develop a practical collected form for the internist.


Eligibility Criteria:
Inclusion Criteria:

* all patients who are over than 60 years old who visit internal medicine outpatient clinic
Effects of Scapular Proprioceptive Neuromuscular Facilitation on Pain and Range of Motion in Patients With Adhesive Capsulitis

The term ''frozen shoulder'' is defined as a clinical condition with restricted active and passive range of motion (ROM) in all directions, including flexion, abduction, and rotation.The objective of the study is to determine the effects of Scapular proprioceptive neuromuscular facilitation and conventional physical therapy among patients with adhesive capsulitis.The study will be a randomized controlled trial (single-blinded parallel study), consisting of 2 groups- interventional group A and interventional group B.Group A will be given conventional physical therapy and group B will be given conventional physical therapy alongwith scapular PNF.Scapular PNF exercises are not included in our routine PT treatment programs and there is limited literature related to the PNF techniques. These techniques help develop muscular strength and endurance, joint stability, mobility, neuromuscular control and coordination all of which are aimed at improving the overall functional ability of patients.


Eligibility Criteria:
Inclusion Criteria:

* Cases diagnosed with adhesive capsulitis, both primary and secondary origin.
* Stage two and stage three of adhesive capsulitis.
* Unilateral adhesive capsulitis.
* Both males and females of the age group 40 years and above.

Exclusion Criteria:

* History of shoulder surgery or manipulation under anesthesia,
* Local corticosteroid injection administration to the affected shoulder within the last 3 months.
* Severe musculoskeletal, neurological and cardiovascular conditions.
Carbon PEEK Versus Titanium Pedicle Screws in the Treatment of Spinal Tumors

Radiation therapy is a cornerstone in the treatment of spinal neoplasms as radical resections are often limited anatomically. Frequently, a surgical stabilization with implants is required. However, metallic implants not only make the CT-based planning of a subsequent radiation therapy more difficult, but might also have an uncontrolled dose modulating effect in adjuvant radiotherapy. At the spine, radiation is limited by the effective dose posed to the relatively radiosensitive spinal cord. While metallic implants might result in an inhomogeneous and uncontrollable dose distribution due to the interface effect, the use of new radiolucent implants consisting of carbon/polyether ether ketone (PEEK) might allow a more homogeneous and predictable dose distribution. This study aims to evaluate the potential benefits of the use of carbon/PEEK pedicle screws during adjuvant radiation therapy and follow-up imaging of spinal tumors.

60 patients will randomized 1:1 into either treatment arm (Pedicle System Carbon/PEEK vs. Pedicle System Titanium). The feasibility of planning the radiation therapy will be evaluated. The postoperatively administered total radiation dose is documented. The radiological visualization of the area of interest will be evaluated The surgical outcome is evaluated by fusion rate, implant integrity and anchorage. Patients will be followed up for 12 months according to local standards.


Eligibility Criteria:
Inclusion Criteria:

* Patients 18 to 99 years of Age
* Primary and secondary spinal tumors of the thoracolumbar spine requiring posterior instrumentation and radiation therapy

Exclusion Criteria:

* Need of cement augmentation or anterior cage support (corpectomy)
* Patients with contraindication against surgical resection
* Patients with incomplete medical records or insufficient imaging