cyrilzakka/clinical-trials huggingface dataset:
The Oslo Acute Reperfusion Stroke Study (OSCAR)

Prospective registry of clinical and radiological data in acute ischemic stroke patients after endovascular treatment.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 years or older
* Patients with ischemic stroke and cerebral arterial occlusion treated with endovascular revascularization.
* All stroke severities and vascular distributions are eligible.
* Informed written consent signed by the patient, verbal consent from the patient as witnessed by a non-participating health care person or consent by the signature of the patient's family must be provided before inclusion. Patients for whom no informed consent can be obtained will not be included in the study but will be treated according to standard guidelines.

Exclusion criteria:

• Patient not eligible for the study or not available for follow-up assessments (e.g. non- resident).
Electrophysiology of the Human Pituitary Gland

Measurment of electrophysiological properties of the human pituitary gland during removal of a pituitary adenoma. Assessment if these properties are sufficient for intra-operative identification of different tissues.

In this study, patients undergoing a surgical resection of a pituitary adenoma as part of standard care will undergo an extra measurement of the electrophysiological properties of the pituitary gland. A single-unit microlectrode will be introduced and placed in the adenoma tissue, anterior piuitary lobe and posterior pituitary lobe. Apart from this measurement, no other interventions are performed and standard care will continue. Six months after measurements the patients chart will be assessed for the occurrence of remission and endocrine deficiencies.

An assessment will be made if these properties are distinctive enough to allow intra-operative identification of the different tissues and thereby increase chances of maximal tumour removal and decrease chance of endocrine deficiencies.

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients undergoing transsphenoidal surgery for pituitary adenoma.
* Identification of the posterior lobe on preoperative MRI. This is most common in patients with micro-adenomas or small macroadenomas.
* Age \>18 years

Exclusion Criteria:

* Emergency surgery
* Cognitive impairments
* Pregnancy
* Pre-existing diabetes insipidus
Estrogen, Diet, Genetics and Endometrial Cancer

The purpose of this study is to see how people's diets, other aspects of their lifestyles, and their individual genetic makeup affect their chances of getting endometrial cancer (cancer of the uterus).

This survey will enroll several hundred women who have or have had endometrial cancer and several hundred who do not. We will compare these two groups of women to see what factors may lead to endometrial cancer.

We will conduct a population-based case-control study in six counties of New Jersey. Cases will be women with newly-diagnosed endometrial or ovarian cancer. Controls will be matched by 5-year age groups and selected by random digit dialing (for those under 65), from Centers for Medicare and Medicaid Services (CMS) files (for those 65 and over), or from neighborhood sampling. Controls will not have had a hysterectomy.

There will be 400 cases with endometrioid tumors, 60 with serous tumors or clear cell tumors, 300 with ovarian cancer, and 400 controls. In addition, there will be a small group of black women included from MSKCC.

We will interview participants about known and potential risk factors for endometrial and ovarian cancer and obtain information on diet. We will obtain DNA for genetic analysis from buccal specimens collected using a mouthwash rinse method. We will use logistic regression to determine odds ratios for disease with various exposures. For endometrial cancer, we will examine the association of risk with genotypes in strata defined by body mass index and dietary fat consumption.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with epithelial endometrial or ovarian cancer within the year before being contacted (cases)
* Aged 21 and over
* Residents of Essex, Union, Morris, Middlesex, Bergen, or Hudson counties, NJ
* Black women with and without endometrial cancer who are seeing gynecologists at MSKCC

Exclusion Criteria:

* Unable to sign informed consent
* Consent withheld by physician (cases)
* Hysterectomy (controls)
* Do not speak English or Spanish
Periarticular Multimodal Drug Injections in Total Knee Arthroplasty

The purpose of this study is to determine whether periarticular multimodal drug injection (PMDI) would provide additional benefits in patients after total knee arthroplasty (TKA) for whom contemporary pain control protocols using the continuous femoral nerve block, intra-venous patient controlled analgesia (IV-PCA)and preemptive oral medications. We hypothesized that PMDI would reduce pain level and consumption of PCA and acute pain rescuer and would provide better functional recovery and patient satisfaction. We also hypothesized that the incidence of side effects and complications of the PMDI would be similar to the No-PMDI.

The preemptive multimodal approaches are regarded as a current standard pain management protocol. Recently, periarticular multimodal drug injection (PMDI) has been considered to be one of the most effective and important component in multimodal approaches. Because the contemporary pain management protocol using the regional anesthesia, continuous femoral nerve block (FNB) and intravenous patient-controlled analgesia (PCA) has been proved significantly improved analgesic effects itself, little information whether the PMDI would provide additional pain relief under this pain management protocol is available. Also, because the safety of the high dose local anesthetics and narcotics has not been clarified, a selective application should be considered to patients who were expected to show better analgesia if there were certain patient related factors to predict the additional pain relief effect of the PMDI. Thus, this prospective double-blind randomized study was conducted to determine whether PMDI would provide additional benefits in patients after total knee arthroplasty (TKA) for whom contemporary pain control protocols using the continuous femoral nerve block, IV-PCA and preemptive oral medications in terms of pain relief, consumption of PCA and acute pain rescuer, patients satisfaction, functional recovery, side effects and complications.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of primary osteoarthritis
* Scheduled for elective total knee arthroplasty
* Signed written informed consent
* Spinal anesthesia

Exclusion Criteria:

* Patients refusing consents
* inability to use the outcome assessment tools
* Contraindications to regional anesthesia
* severe cardiovascular disease
* allergy or contraindication to drugs used in this study
* pre-existing neurologic disease including psychiatric disorder
* drug abuser
DAta-driven PersonaLIzation of a DigitAl Health Solution to Support Family Caregivers of Children with Chronic Conditions

The goal of this feasibility study is to explore the needs of families with children with obesity and evaluate the impact of a combined intervention (children with obesity receiving pharmacological therapy in combination with the Adhera Caring Digital Program®) on treatment satisfaction, adherence, and mood. The main objectives are:

* To evaluate the impact of the treatment combination (ACDP® and pharmacological treatment) in terms of satisfaction, engagement, adherence and mood, in families with children with obesity.
* To better understand the educational and support needs of the families of children with obesity while under treatment and lifestyle changes.

Participants will:

* Use the Adhera Caring Digital Program® (ACDP®) for obesity, which includes digital therapeutic software, personalized messages, and educational materials.
* Take pharmacological treatment as prescribed for one year.
* Wear activity wristbands/watches to collect biometric data.
* Attend monthly clinic visits for assessments and monitoring.
* Complete psychometric questionnaires to measure satisfaction, adherence, and emotional outcomes.
* Engage in chat-based communication and video conferencing with health coaches for support and monitoring.


Eligibility Criteria:
Inclusion criteria:

* Caregivers of children between 13 and 18 years who are diagnosed with obesity and undergoing treatment according to the approved label by AEMPS1 (adolescents with obesity aged 12 years and older with an initial BMI at the 95th percentile or greater for age and sex).
* Families of children with obesity who have been under pharmacological treatment before screening. This includes treatment with any of the following medications orlistat, metformin, liraglutide, semaglutide.
* Participants who are willing to join ACDP® for 10 months and can interact with a smartphone during that time.
* The family is willing to complement the pharmacological obesity treatment with a digital intervention.
* Participants (patients and their caregivers) must be willing to use wearables for the entire length of the study.
* Parents previously using a wearable will agree not to use it during the length of the study, as their wearable account must be synched to the patient's device. Further, they may need to agree on changing the account data for height, weight, and gender in their Google account.

Exclusion criteria:

* Families not fluent in Spanish.
* Families of children with obesity and comorbidities.
* Families of children with secondary causes of obesity (i.e., hypothalamic, genetic or endocrine causes).
Non-invasive Point-Of-Care Hemoglobin Testing In An Obstetric Population

Anemia is common during pregnancy due to increased metabolic rate and normal physiologic changes associated with pregnancy. Anemia during pregnancy has been associated with increased of adverse outcomes during delivery and the postpartum period. Currently, it is recommended to screen for anemia at three pre-specified points during routine prenatal care, typically 3 months apart. This screening method may miss patients who develop anemia between these intervals and lead to a delay in diagnosis and treatment.

MasimoTM has developed a non-invasive device that can detect anemia without a blood draw. This device has not been extensively studied in pregnant patients. The aim of this study is to determine the agreement in hemoglobin readings between the non-invasive device and the standard of care blood draws in pregnant patients.

This is a prospective observational study of a non-invasive hemoglobin measurement device in a pregnant patient population. The device is FDA approved for use in adults, children, and neonates. The current standard of care for anemia screening during pregnancy involves performing invasive venipuncture at two separate visits throughout the course of the pregnancy. The purpose of this research study is to compare the device performance with the gold standard hemoglobin measurement (venipuncture) when patients receive routine hemoglobin measurement during the course of their prenatal care.

The research team will approach pregnant patients who are presenting for prenatal care at Beth Israel Deaconess Medical Center, including the Labor and Delivery Triage Unit. The research team also will approach patients during an antepartum or postpartum admission.

The research team will use the Masimo Rad-67 handheld co-oximeter which has a reusable finger-tip sensor that enables spot-check monitoring measurements of both oxygen saturation and non-invasive hemoglobin measurement. Study personnel will receive training on proper device use and cleaning by the local Masimo support team.

At the time of a blood draw, the research team will place the pulse oximeter on the participant's finger. The devices requires 1-3 minutes for an accurate measurement.

After the measurement is complete, the participant will be asked 2 questions on their satisfaction and comfortability with the device and 1 question regarding their skin tone using a validated skin tone scale.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant or postpartum;
* Age ≥18 years old;
* Undergoing phlebotomy for clinical purpose

Exclusion Criteria:

- None
Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome

The Investigators will test the hypothesis that nonselective beta-blockers would have a more pronounced effect on platelet aggregation than selective beta-blockers in patients with acute coronary syndrome treated with dual anti platelet therapy.

In patients with acute coronary syndrome (ACS) beta-blockers are recommended for secondary prevention. It is known that catecholamine levels can potentiate platelet reactivity and beta-blocking agents may also affect platelet aggregation. This effect is mainly mediated by adrenergic receptors on platelets. This suggests that nonselective beta-blockers would have a more pronounced effect on platelet aggregation than selective beta-blockers. However, little is known about the effect of beta-blockers on platelet aggregation in patients with cardiovascular disease and, to date, nothing is known in the setting of ACS.

The aim of the present study is to evaluate the effect of selective and nonselective beta-blockers on platelet aggregation in ACS patients treated with dual anti platelet therapy.

Eligibility Criteria:
Inclusion Criteria:

* Acute Coronary Syndrome
* Current dual anti platelet treatment with acetylsalicylic acid and Ticagrelor

Exclusion Criteria:

* ongoing prasugrel, ticlopidine or clopidogrel therapy
* Creatinine Clearance \< 30 ml/min/1.73mm2
* Moderate to severe anemia Hemoglobin \< 10 mg/dl
* Platelet count \>600000/mm3 or \<150000/mm3 or hematocrit \>50% or \<25%
* concomitant neoplastic or immune-mediated pathologies
* severe pulmonary pathologies
* contraindication to beta blocker therapy.
Causes of Chronic Pruritus

The aim of this study is to include all patients followed between 2008 and 2018 in order to analyze the etiologie of the chronic pruritus


Eligibility Criteria:
Inclusion Criteria:

* more than 18 years old
* In patient in a day hospital or longer hospitalization in the dermatology department
* With chronic pruritus which means pruritus longer than 6 weeks without skin lesions specific to pruritic dermatitis.

Exclusion Criteria:

* Itchy dermatose
* Refusal to particpate
Real-life Management of Patients Eligible for CAR-T Cell Therapy

Adoptive immunotherapy using CAR-T cells is now one of the Advanced Therapy Medicines routinely used for relapsed or refractory lymphoid hemopathies. In 2023, in France, 5 types of CAR-T cells have marketing authorization for 6 different indications. However, these marketing authorizations are based on clinical trials involving a limited number of selected patients. Real-life data are essential for assessing the post-authorization use of these innovative treatments. The French national DESCAR-T registry, promoted by LYSARC and in which Toulouse University Hospital plays an active role, is an international reference for this real-life evaluation. It does not, however, allow precise evaluation of patient-centered indicators and care pathways.

With the increasing number of indications and candidate patients, Toulouse University Hospital, the only healthcare facility authorized in the Western Occitanie region to administer CAR-T cells, is faced with growing hospital needs and longer treatment times. In 2023, this has necessitated the implementation of new ambulatory and inter-facility care pathways in collaboration with the referral centers of the Onco-Occitanie Ouest regional cancer network. The selection of patients for CAR-T cell treatment is based on objective clinical criteria linked to the pathology (histology, morphological localization, size and kinetics of the tumor mass) and the patient (physiological age, performance index, comorbidities, patient choice). Because of their innovative nature, in a difficult psychological and physical context for the patient (refractory disease), CAR-T cell care pathways also need to be evaluated in terms of their "quality of life" dimension. The impact of non-biological determinants (also described as social and territorial inequalities in health) such as place of residence and distance from healthcare provision, marital, economic and social status, has never been explored on the accessibility and progress of the CAR-T cell treatment pathway.

The creation of a registry of patients eligible for CAR-T cells at Toulouse University Hospital will enable these lines of research to be explored on the scale of a region with a population of 3 million.

Ambispective observational cohort: This observational study is monocentric. For each patient, data will be collected during 5 years.

Eligibility Criteria:
Inclusion Criteria:

* Patient eligible for CAR-T treatment for hemopathy at TOULOUSE University Hospital under early access or marketing authorization or as part of a clinical trial between 01/01/2019 and 31/12/2028
* Patient able to understand the purpose and constraints of the research project
* Patient has read the study information leaflet and does not object to the research.

Exclusion Criteria:

* Patient under guardianship, curatorship or safeguard of justice
* Patient objects to the collection of data concerning him/her
rTMS and Retraining in Focal Hand Dystonia

This study is exploring a new experimental procedure in dystonia called repetitive transcranial magnetic brain stimulation (TMS) combined with rehabilitation. The purpose of the study is to determine whether repetitive TMS is effective as a treatment to reduce symptoms in dystonia as demonstrated by improved motor performance.

BACKGROUND: Though the etiology of focal hand dystonia (FHD) is uncertain, two primary factors implicated in the development of dystonic symptoms are excessive cortical excitability and impaired sensorimotor processing.

OBJECTIVE: The purpose of this study was to determine the functional efficacy and neural effects of a Dual intervention of rTMS and sensorimotor retraining. Our working hypothesis is: subjects receiving the combined intervention will (1) display significantly improved handwriting measures; (2) report significant improvement in daily functional ability; (3) display reduced hand cramping compared; and (4) demonstrate reduced corticospinal excitability after the Dual intervention when compared to the rTMS+ stretching and massage (Sham) intervention.

METHODS: A randomized, single-subject, multiple baseline design with crossover is used for this study that will examine ten subjects with FHD with two interventions: five days of low-frequency 1 Hz rTMS + sensorimotor retraining (Dual intervention) vs. rTMS + stretching and massage (Sham). The rTMS is applied to the premotor cortex at 1 Hz at 90% resting motor threshold for 1200 pulses. For sensorimotor retraining, a subset of the Learning-based Sensorimotor Training program was followed.

Eligibility Criteria:
Inclusion Criteria:

* Greater than 18 years of age
* Symptoms of focal hand dystonia or writer's cramp

Exclusion Criteria:

* History of seizure or other neurologic disorder
Public Health Initiative on Alcohol Flushing

The overall aim of the study is to raise awareness of alcohol flushing and its health risks to the general population.

The primary objective is to see if spreading awareness of the health risks of alcohol flushing and understanding personalized genotype information will lead to changes in alcohol consumption behavior.


Eligibility Criteria:
Inclusion Criteria:

* Adult age over 18
* Native English speaker

Exclusion Criteria:

* None
Low-chlorine Vs High-chlorine Crystalloids in Septic Shock Adults

Fluid resuscitation is an important treatment in septic shock patients, however whether crystalloid composition affects septic shock patients outcomes remains unclear. According to previous studies, low-chlorine crystalloids could significantly reduce the incidence of kidney injury and 30-day mortality compared with high-chlorine crystalloids in critically ill adults. Therefore, we hypothesized that the use of low-chlorine crystalloids would result in a lower incidence of major adverse kidney events within 30 days (MAKE 30: overall incidence of death, new renal-replacement therapy, and persistent renal dysfunction) than high-chlorine crystalloids in septic shock adults.


Eligibility Criteria:
Inclusion Criteria:

1. 18 years old \<age ≤ 85 years old;
2. Diagnosis of septic shock within 24 hours (sepsis 3.0);
3. Needing fluid resuscitation judged by clinicians;
4. The patient or the patient's legally acceptable representative signs the informed consent (signs within 24h of enrollment)

Exclusion Criteria:

1. Pregnant or lactating period;
2. Renal replacement therapy has been received or expected to receive within 6 hours;
3. Those who were previously enrolled in the study;
4. Estimated death within 24 hours;
5. Other situations that not suitable for enrollment judged by researchers.
The Effect of The 6 Week Online Exercise Program On Core Stability And Vertical Jump Performance In University Students

The goal of this randomized controlled study is to examine the effect of the online exercise program on core stabilization and vertical jump performance and observe the relationship between physical activity levels and motivation. In addition, compare these parameters with the exercise group and control group. The main questions it aims to answer are:

Does a 6-week online exercise program at university have an effect on core stabilization and vertical jump? Does exercise have an effect on motivation and physical activity level?

Background: The importance of physical activity and exercise is increasing day by day. The aim of this study is to examine the effect of the online exercise program on core stabilization and vertical jump performance and observe relationship with physical activity levels and motivation.

Methods: The study included 51 healthy volunteer students registered at Fenerbahçe University and actively continuing their education. Evaluations were made before the exercise program and at the end of the sixth week. All assessments and exercise program were conducted online. Two of Mcgill's trunk muscle endurance tests were preferred to evaluate core stability: Trunk extensor endurance test (TEET), bilateral side bridge endurance tests (SBET), and Prone Bridge Test (PBT) was preferred for flexor endurance. Vertical Jump (VJ) test was used to evaluate vertical jump height performance. The International Physical Activity Questionnaire-Short Form (IPAQ-SF) was used to determine the physical activity levels of individuals, and the Physical Activity Participation Motivation Scale (MSPPA) was used to measure their motivation to participate in physical activity.

Eligibility Criteria:
Inclusion Criteria:

* Being an university student
* Having a good health
* Participant in ages between 18-27 years of age
* Participating to the study in a voluntary basis

Exclusion Criteria:

* Having had orthopedic surgery in the last 60 days
* Severe neurological or vestibular disease that would interfere with exercise
* Taking any medications that could affect balance