cyrilzakka/clinical-trials huggingface dataset:
Effect of Propolis on Patients Infected With H. Pylori

This research aims to contribute to the literature by researching the effect of propolis as an add-on treatment and nutritional education on patients with H pylori and the alleviation of gastrointestinal symptoms.In order to achieve this, we offered propolis and educational nutrion programme to our 96 patients and check on their symptoms on a regular basis to note any improvement by measuring the alleviation using GSRS.

The informed voluntary consent was taken from the patients who agreed to attend the research and the patients, Group 1 propolis with lactic acid extract on top of the treatment given by doctor Group 2 Lactic acid extract on top of the treatment by the doctor Group 3 the treatment given by the doctor and placebo treatment ,will be distributed by the method of randomized double blind trial.The patients will be provided with 500 mg (≌60 drops/day) of propolis or propolis with lactic acid extract in the morning,afternoon and evening for 14 days.The face-to-face Survey data collection method will be utilized and the researcher inform the patients about the diet and nutrition education against pylori and propolis.The presentation for the Patient Education and Propolis is given in the appendix.

The survey form consists of 4 parts; descriptive general information,eating habits,Gastrointestinal Symptoms Rating Scale (GSRS) and the frequency of The consumption of particular food. In order to rate the gastrointestinal symptoms of the patients the GSRS scale which was validated and deemed reliable in Turkish will be used The foods that increase the frequency of gastrointestinal symptoms such as spicy foods,chocolate,Chips,carbonated drinks,citrus fruits are also questioned in terms of frequency of consumption.

In order to investigate the patients adherence to the study, reminders will be taking place by giving them a call two times a week. At the end of the intervention period,GSRS scale will be reused to assess the patients.

Eligibility Criteria:
Inclusion Criteria:

* The detection of H pylori infection by a specialized physician.

Exclusion Criteria:Bees and bees products allergies and the patients who use drugs that has bleomycin as an active compound will be excluded as it was found in the rats that these types of antitumor drugs can interact with propolis
Reversal of Right Ventricular Steatosis in Pulmonary Hypertension

The goal of this study is to elucidate the relationship between myocardial right ventricular triglyceride content (steatosis) and right ventricular dysfunction in participants with pulmonary hypertension, and investigate reversibility of this phenotype with omega-3 fatty acid treatment.

The investigators propose to treat 30 participants that are identified as having elevated myocardial triglyceride content (defined as greater than 0.50%) on cardiac MRI with 4 grams of omega-3 fatty acids daily for six months with a primary end point of reducing right ventricular steatosis and a secondary endpoint of improving RV systolic function. The investigators hypothesize that right ventricular steatosis by cardiac MRI will be associated with the degree of right ventricular systolic function by cardiac MRI. In the subset of participants with elevated baseline steatosis who are treated with a lipoprotective strategy, the investigators hypothesize that six months of therapy with omega-3 fatty acids will reduce myocardial steatosis and improve right ventricular systolic function.

Eligibility Criteria:
Inclusion Criteria:

* Adult men and women \> 30 years of age with a diagnosis of pulmonary hypertension (defined as mean pulmonary arterial pressure ≥25 mmHg at rest on right heart catheterization)

Exclusion Criteria:

* Contraindication to MRI (e.g., metallic hazards or allergy to gadolinium)
* Renal dysfunction (eGFR \< 60 ml/min/1.73m2 as estimated by the Modified Diet in Renal Disease formula)
* High risk features for nephrogenic systemic fibrosis (solitary kidney or prior renal transplant)
* Active pregnancy or breastfeeding (determined by urinary pregnancy test before CMR)
* Weight \> 550 lb or waist diameter \> 70 cm (limits for our Siemens Verio CMR system)
* Fish Allergy
The Effects of Maxipost (BMS 204352) on Cerebral Hemodynamic and Headache in Healthy Volunteers and Migraine Patients

It is not previously investigated whether, there is a correlation between potassium channels and migraine, so it is unclear whether, this signaling pathway through potassium channels has an impact on migraine pathophysiology.

Maxipost (BMS 204352) is a vasoactive molecule that causes vasodilation via the big calcium dependent potassium (BKCa) channel signaling pathway. Maxipost decreases the blood pressure and maxipost infusion causes headache in healthy volunteers. A possible coherence between maxipost and headache/migraine in healthy volunteers and migraine patients is yet to be investigated.

The present study aims to clarify a possible coherence between maxipost and headache/migraine and it will help to shed light on the importance of potassium channels in migraine. In general, the study will contribute to a greater understanding of migraine pathogenesis and possibly lead to development of specific migraine treatment.


Eligibility Criteria:
Inclusion Criteria:

* Migraine patients without aura who fulfill criteria in the international classification of headaches. This does not apply to healthy volunteers.
* 18-60 years.
* 50-90 kg.
* Women of childbearing potential must use adequate contraception.

Exclusion Criteria:

* Headache less than 48 hours before the tests start
* All primary headaches, except migraine without aura for migraine patients, according to international classification of headache
* Daily consumption of drugs of any kind other than oral contraceptives
* Pregnant or nursing women.
* Cardiovascular disease of any kind, including cerebrovascular diseases.
The Efficacy of Peripheral Nerve Blocks With Intrathecal Morphine in Improving Analgesia After Unilateral Total Knee Arthroplasty

The purpose of this study is to determine whether intrathecal morphine (ITM) alone or its combination with peripheral nerve blocks (PNB) provides better analgesia for patients undergoing total knee arthroplasty (TKA).

Total knee arthroplasty (TKA) surgery is associated with severe pain. The success of knee rehabilitation following surgery depends largely on adequate pain control that permits early physical therapy. Postoperative modern analgesic recommendations specific to TKA propose either spinal block with intrathecal morphine (ITM) or a combination of general anesthesia with single shot femoral nerve block (SFNB). Femoral nerve block (FNB) too has proven analgesic advantages in TKA surgery. However, we do not know if the combination of the two analgesic techniques, ITM and peripheral nerve blocks (PNB), provides superior analgesia to ITM alone.

Thus, this study aims to determine whether ITM alone or its combination with PNB provides better analgesia for patients undergoing total knee arthroplasty (TKA).

Eligible patients undergoing unilateral TKA under spinal anesthesia consenting to a multimodal analgesic regimen inclusive of ITM, FNB, and SNB will be recruited. All patients will receive spinal with intrathecal morphine. Patients will be randomly assigned using a computer generated table of random numbers to receive either spinal with intrathecal morphine (morphine group), a combination of intrathecal morphine and femoral nerve block (morphine-femoral group), or a combination of intrathecal morphine and femoral nerve block as well as sciatic nerve block (morphine-femoral-sciatic group).

Eligibility Criteria:
Inclusion Criteria:

* ASA I-III patients undergoing unilateral TKA under spinal anesthesia and nerve blocks
* Ages 18-80
* BMI ≤ 38 kg/m2

Exclusion Criteria:

* BMI \> 38 kg/m2
* chronic pain disorders
* Significant pre-existing neurological deficits or peripheral neuropathy affecting the lower extremity
* abuse of drugs or alcohol
* Contraindication to a component of multi-modal analgesia
* Contraindication to spinal anesthesia or failure to institute spinal anesthesia after performing femoral and sciatic blocks
* Bilateral TKA surgeries
* History of significant psychiatric conditions that may affect patient assessment
* Pregnancy
* Moderate to severe obstructive sleep apnea.
* Previous adverse reactions resulting from intrathecal opioids (respiratory depression, urinary retention, severe pruritis, severe nausea or vomiting, severe sedation)
* inability to provide informed consent.
Metabolic Response to Food in Lung Cancer

This goal of this study is to describe how unintentional weight loss influences fasting and post-prandial metabolic flexibility in participants with advanced non-small cell lung cancer.


Eligibility Criteria:
Inclusion Criteria:

* Age greater than or equal to 18 years
* Diagnosis of non-small-cell lung cancer
* Reported weight stability or loss after cancer diagnosis
* Body mass index less than or equal to 35 kilograms per meter squared
* Ability to provide written informed consent
* Willing and able to comply with all scheduled visits, treatment plans, lab tests, and other study procedure
* Allow the collection and storage of biospecimens and data for future use

Exclusion Criteria:

* Prior diagnosis of diabetes mellitus (type 1 or type 2)
* Currently pregnant or breastfeeding
* Contraindication to consuming the liquid mixed meal
* Any medications affecting gastric motility
* Any other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
A Pilot Study to Explore the Use of Skin Biopsy as Diagnostic Tool in Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)

ACNES is a neuropathic pain condition of the abdominal wall. It is a clinical diagnosis based on patient's history and physical examination. No diagnostic test is available to confirm the diagnosis.

This pilot study will determine if skin biopsies can be used as diagnostic test. Two 3mm biopsies will be taken and used to count the small nerve fibres in the skin. The number of small nerve fibres of the painful skin will be compared to non-painful skin. Skin biopsy and small fibre nerve count is already used as diagnostic test in patients with small-fibre neuropathy.

The investigators hypothesize that patients with ACNES will have a reduced number of small nerve fibres in the affected skin, compared to the non-affected skin.


Eligibility Criteria:
Inclusion Criteria:

* Duration of pain \>3 months
* Newly diagnosed unilateral ACNES
* Fully completed intake questionnaire
* Obtained written informed consent

Exclusion Criteria:

* Inability to understand Dutch language
* Bilateral ACNES
* Previously administered injections with corticosteroids at trigger point (injection with a local anaesthetic is allowed)
* Previous Pulsed Radiofrequency (PRF)-treatment at trigger point
* History of open abdominal surgery
* History of neurectomy
* Known neuromuscular or neurodegenerative disease
* Antiplatelet or anticoagulants use or known coagulation disorders
* Disorder known to cause a reduced IENFD;

  * Diabetes
  * Hypothyroidism
  * Renal failure
  * Vitamin B12 deficiency
  * Monoclonal gammopathy
  * Alcohol abuse (\>5 IU a day)
  * Malignancies
  * Medication that cause neuropathy (for example chemotherapy)
Mitral Valve Prolapse, Arrhythmias and Mitral Valve Surgery

Mitral valve prolapse (MVP) is associated with malignant ventricular arrhythmias (VA) and sudden cardiac death. A proper electrophysiological and echocardiographic characterization of this population is missing. Moreover, the effects of mitral valve repair on the arrhythmic burden are still matter of debate.

The investigators sought to explore the role of the arrhythmic substrate in the risk stratification of patients with MVP and to assess whether mitral surgery is followed by a significant modification of the baseline arrhythmic pattern.

This is a prospective observational study, enrolling 200 patients with MVP and any documented VA.

Diagnosis of VA obtained by 12 leads ECG and Holter recordings will be reported, as well as preprocedural premature ventricular contractions (PVC) burden assessed by 24-hour Holter monitoring; demographic and clinical data will be collected, including symptoms, documentation of VA and atrial fibrillation (AF). Echocardiography data will be analyzed, focusing on mitral regurgitation grading and mitral valve morphology analysis, assessment of leaflet redundancy and prolapse, chordal elongation, annular dilatation, presence of calcifications and mitral annular disjunction characterization.

Patients will undergo ECG Holter monitoring before Cardiac Surgery with the aim to identify any VA and estimate PVC burden. ECG Holter monitoring will be repeated at 3, 9, and 12 months after cardiac surgery. In case of intraoperative biopsy, the result of histopathological examination will be collected. For patients undergoing cardiac imaging, including Cardiac Magnetic Resonance or Computer Tomography, data regarding cardiac volumes, function, markers of fibrosis will be collected. In patients undergoing Programmed electrical stimulation (PES) and Electroanatomical Mapping (EAM), size of bipolar and unipolar endocardial abnormal voltage areas, Late Potentials (LP) area, results of programmed electrical stimulation, will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

1. Adult 18 years of age or older, at the time of inclusion;
2. Hospitalized or presented in outpatient visit;
3. And presented with:

   • Diagnosis of MVP
4. Who underwent electrophysiological evaluation or cardiac surgery for mitral valve disease.

Exclusion Criteria:

1. Patients not willing to participate to the study
2. Patients without clinical evaluation of the arrhythmic profile.
Influence of tDCS on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).


Eligibility Criteria:
Inclusion Criteria:

* Right-handed according to the Oldfield Händigkeits inventory (lateralization index\> 70) (1971)
* Cognitive impairment according to the diagnostic criteria of a MCI (amnesic or even multiple domains)
* No therapeutic treatment with AChE inhibitors
* No motor impairments relevant to everyday life
* Age 50 to 80 years

Exclusion Criteria:

* Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
* Epilepsy, epileptic seizure in medical history
* Cognitive deficit (MMSE \<20)
* Depressive episode (Beck Depression Inventory (BDI)\> 12)
* Newly taking (\<3 months) centrally active drugs, particularly acetylcholinesterase inhibitors
* Pregnancy
* Pacemaker (contraindication for MRI)
* Other metal parts in the body (contraindication for MRI)
Effect of Kinesio Taping on the Stability of Knee in Soccer Players

Objective: The general objective of this study is to determine the possible beneficial effect of the application of kinesiotaping, as well as the performance of proprioceptive exercises on parameters related to knee stability, such as the incidence of injuries, pain, static stability Or dynamics, and flexibility, in amateur soccer players, with a workload of 3 days per week plus the match.

Material and methods: Amateur soccer players are divided into 3 groups.

Group 1 (G1) performs proprioceptive exercises plus the application of kinesiotaping without tension in the knee.

Group 2 (G2) performs proprioceptive exercises plus the application of kinesiotaping with tension in the knee.

Group 3 (G3) is placed kinesiotaping with tension in the knee, without proprioception exercises.

The treatment will last four weeks and three evaluations, one before treatment, another at two weeks and the last one at the end of treatment.


Eligibility Criteria:
Inclusion Criteria:

* Football players
* Over 18 years with experience in this sport over 5 years

Exclusion Criteria:

* Players with pathologies that prevented them from playing football normally
* Recent serious injuries
* Allergy to kinesiotaping
* Impossibility to complete the study
Uncontrolled Lower Respiratory Symptoms in the WTC Survivor Program

The purpose of this study is to understand why patients in the World Trade Center program have continuing breathing problems. This study will improve investigators understanding of breathing problems among individuals with World Trade Center exposure by allowing them to review and monitor medication use, lung function, and examine other conditions that can contribute to problems with breathing. The findings from the study will help investigators understand why some people have persistent lower respiratory symptoms (breathing problems) after their exposure to World Trade Center dust and fumes, and may help guide better management and treatment of these symptoms.

Investigators will conduct a clinical study with aggressive treatment for lower respiratory symptoms in patients in the World Trade Center Environmental Health Center. Patients in the WTC EHC with uncontrolled LRS at visit 1 will be identified and placed on high-dose inhaled corticosteroids and long-acting beta agonists for three months. Adherence will be assessed at monthly visits. Patients will perform spirometry and oscillometry at baseline and after 3 months of treatment. They will also be assessed for markers of airway inflammation, bronchial hyperresponsiveness and co-morbid conditions including depression,anxiety,post-traumatic stress disorder, gastroesophageal reflux, paradoxical vocal cord motion and rhinosinusitis.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years and \<75
* Meet criteria for World Trade Center Environmental Health Center enrollment
* Onset of lower respiratory symptoms after 9/11/01
* Persistent lower respiratory symptoms (\> 2 times per week)
* Pre-bronchodilator forced expiratory volume in one second (FEV1) within normal limits
* \< 5 pack-year tobacco history
* Not current smoker
* Asthma Control Test Score ≤ 19
* Normal chest x-ray

Exclusion Criteria:

* Age \< 18 years and ≥75
* Lower respiratory symptoms or asthma history pre 9/11/01
* No persistent lower respiratory symptoms
* pre-bronchodilator FEV1 within normal limits
* \> 5 pack year tobacco
* Current smoker
* Abnormal Chest X-Ray or parenchymal changes on high resolution computed tomography
* Uncontrolled major chronic illness (diabetes mellitus, congestive heart failure, cancer)
* History of significant non-World Trade Center occupational or environmental exposure
* Allergy to study drug
* Pregnancy, lactation or plans to become pregnant
* Chronic oral corticosteroid use
* High risk of fatal or near-fatal asthma within the previous 2 years
* Other lung disease (Idiopathic pulmonary fibrosis,sarcoid, etc.)
Antiretroviral Improvement Among Medicaid Enrollees

This study will evaluate whether a new program will affect how often human immunodeficiency virus (HIV) antiretroviral therapy (ART) prescriptions are filled and whether the program improves the health of people living with HIV.

Virginia Commonwealth University and study collaborators are working together to learn about challenges that Virginia Medicaid members have in taking their prescribed medication. To do this, the researchers are implementing and evaluating a program called Antiretroviral Improvement among Medicaid enrolleeS (AIMS). This program is designed to support members to fill ART prescriptions.

The program involves supporting Medicaid members with HIV directly by talking to them about challenges with filling their ART prescriptions and linking them to resources that can help with those challenges. Some members will be offered access to warm health technology support.

The researchers think this support may increase how often ART prescriptions are filled and hope that the AIMS program can improve individuals' health and increase HIV viral suppression.

Eligibility Criteria:
Inclusion criteria:

* Current enrollment in Virginia Medicaid;
* Continuous Virginia Medicaid enrollment for the preceding 9 or more months;
* Current age 19-64 years;
* Identified as living with HIV according to an HIV case identification algorithm;
* Non-dual eligible for Medicare;
* History of ART prescription claim(s) within the past 12 months;
* Prior ART prescription claim, with claims for the most recent ART prescription refill(s) \>30 days late.

Exclusion criteria:

* Record of non-Medicaid health insurance or other health care service payer in past 3 months;
* New prescription claim(s) within 30 days for within-class ART drug(s) not previously prescribed;
* Service claim(s) for resistance testing and other ART prescription claim(s) within 30 days of most recent late ART prescription(s) for ART drug(s) not previously prescribed;
* Enrollee's linked HIV provider practices at a healthcare facility offering PositiveLinks;
* No record in the Virginia HIV surveillance data;
* Non-English speaking.
Study of the Correlation Between Muscle Oxygenation and Motor Function in Children With Neuromuscular Disease.

Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls. Up to date, pediatric data are lacking.

The study aims at demonstrating if a correlation exists between the motor deficiency and the muscular deoxygenation in children suffering from neuromuscular disorders.

Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls, as it was demonstrated in Becker muscular dystrophy patients and fascioscapulo humeral muscular dystrophy. Moreover, the deoxygenation kinetics was positively correlated to the functional status and the muscular deficiency severity. However, no pediatric study has been conducted on this topic up to date.

The aim of the study is to determine if a correlation exists in children suffering from neuromuscular diseases:

* between muscular oxygenation and the percentage of the 6 minutes walking test performed in the routine medical care
* between muscular oxygenation and the total and D1 motor function measure value

Eligibility Criteria:
Inclusion Criteria:

* Children from 6 to 18 years-old suffering from a neuromuscular disorder
* Able to walk, with or without help

Exclusion Criteria:

* Hypoxia secondary to heart or lung disease
* Visual impairment (\<5/10)
* Parents refusal concerning data storage