cyrilzakka/clinical-trials huggingface dataset:
The Efficacy of Implementing Nurse-performed Ultrasound-guided Peripheral Intravenous Access in Oncology Patients

The purpose of this study is to investigate the clinical efficacy of nurse-performed ultrasound-guided intravenous access in oncology patients on the oncological outpatient unit in the National Hospital of the Faroe Islands.

This project is prospective, interventional, clinical study aligned in four different time stages.

In the first stage, the pre-implementation stage, procedures are as usual, where the patient receives intravenous access via the use of the traditional palpation technique and data will be registered. In the next stage, the training stage, the nurses on the oncological outpatient unit will be trained in the use of the ultrasound-guided technique to place peripheral intravenous catheters and will be supervised by specialists in ultrasound. In the third stage, the implementation stage, the nurses will use the ultrasound technique as a daily routine in their practice. In the fourth stage, the post-implementation stage, the same data registration as in the first stage will be registered (see outcome measures) and the results will be compared in order to see the efficacy before and after implementation of ultrasound guidance. It is estimated a total sample of 100 cannulation procedures with approximately 30 patients needed in the pre-implementation and post-implementation stages.

Eligibility Criteria:
Inclusion Criteria:

* Cancer patients admitted to the oncological outpatient unit are eligible for inclusion if they are scheduled for treatment with chemotherapy requiring placement of peripheral intravenous catheter, aged 18 years or older, and reside in the Faroe Islands.

Exclusion Criteria:

* Lack of informed consent and mental incapacity.
Maternal Loss of Control Eating

This study focused on investigating the effects of maternal disordered eating on maternal and child outcomes as part of a secondary data analysis of the Avon Longitudinal Study of Parents and Children (ALSPAC).

Deidentified and anonymised data already collected as part of the ALSPAC study will be analysed to investigate the effects of maternal eating on maternal and child outcomes (diet, eating, weight, metabolic). The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal, prospective study designed to examine the effects of environment, genetics and other factors on health and development.All pregnant women living in the geographical area of Avon, UK, who were expected to deliver their baby between 1st April 1991 and 31st December 1992, were recruited. 14,541 women were enrolled. Amongst these pregnancies, there were a total of 14,676 fetuses, resulting in 14,062 live births and 13,798 children who were alive at 1 year of age and were singletons. The ALSPAC study website contains details of all the data that is available through a fully searchable data Dictionary (http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary/).

Missingness will be assessed and standard data analytical techniques such as MI will be used.Crude and adjusted logistic, linear, and multinomial regression models will be employed.

Eligibility Criteria:
Inclusion Criteria:

-

Exclusion Criteria:

* multiple pregnancies
* no questionnaire data at 32 weeks.

eligibility criteria : enrolled in the ALSPAC study; inclusion: all women part of the ALSPAC study;
The Georgia Latino AIDS/HIV Diagnosis and Linkage in Youth (GLADLY) Project

This study aims to understand the barriers to receiving HIV testing and retention of care for at risk and HIV positive young adults. This study also seeks to determine the feasibility and acceptability of HIV testing in a non-clinical setting.

This study aims to identify factors that can facilitate or impede the use of non-clinical HIV testing venues as well as identify potential testing sites and assess acceptability of an HIV prevention intervention. In addition, the study will implement a pilot intervention to test the feasibility non-clinical HIV testing and follow up events for HIV positive youth.

Eligibility Criteria:
Inclusion Criteria:

* Sexually active
* HIV positive or negative
* Latino youth ages 18-24 years
* Residents of the state of Georgia and can understand spoken and written English or Spanish.

Exclusion Criteria:

* Unmet inclusion criteria
VDR and TFIP11 Gene Polymorphism and Gene-environmental Interaction in Adults

VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

TFIP11 and VDR genes are related to enamel formation genes

Eligibility Criteria:
Inclusion Criteria:

* adult be between 24 and 40 years old
* subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) DMFT≤4 , or, DMFT\>13.9

Exclusion Criteria:

* systemic or genetic disorders
* orthodontic appliances
* pregnant women
Modulation of Esophageal Inflammation in Barrett's Esophagus by Omega-3 Fatty Acids

This study is being done to understand the effect of dietary omega-3 fats in decreasing tissue inflammation in Barrett's esophagus.


Eligibility Criteria:
Inclusion Criteria

* Presence of BE defined as ≥ 1 cm of visible columnar mucosa in the distal esophagus with intestinal metaplasia on histology.
* Absence of high grade dysplasia or EAC on baseline histology.
* BMI \> 30 kg/m2 or waist circumference \> 102 cm in men, \> 88 cm in women.
* Ability to give informed consent.

Exclusion Criteria

* Allergy to ω3 FFAs, fish or shellfish.
* Presence of high grade dysplasia or cancer on histology.
* Pregnant and or breastfeeding women
* Presence of esophagitis on initial endoscopy or symptoms of refractory GERD (heartburn or regurgitation ≥ 2 times a week) indicative of uncontrolled gastroesophageal reflux.
* Inability to give informed consent.
* Currently taking Omega3 FFA as prescription.
* Anti-coagulant therapy (Plavix, Warfarin, Coumadin)
* AST or ALT level \> three times upper limit of normal at baseline
* LDL \> 200 mg/dl at baseline.
* INR \> 2
GREAT - Good Response With Appropriate Treatment

The symptoms associated in advanced cancer patients and adverse events due to use of opioids have major influence on the state of health and quality of life of patients. The pain, in particular, is a symptom with severe negative impact and with a prevalence ranging between 33% and 64%, according to the stage of the disease, with values around 70-90% in advanced stages and metastatic.

The use of opioids, however, is usually associated with the appearance of common adverse events as drowsiness/sedation, constipation, nausea/vomiting, and dizziness. Some effects are self-limiting in the time for the appearance of tolerance while others, as constipation persist.

Several clinical studies have demonstrated that the association oxycodone-naloxone (OXN), which consists in the union between a molecule agonist and an antagonist of opioid receptors, reduced the constipation in the presence of unchanged analgesic efficacy compared to oxycodone alone.


Eligibility Criteria:
Inclusion Criteria:

* Patients with diagnostic (histological or cytological) evidence of locally advanced or metastatic solid tumour;
* With average pain intensity \> 4, measured with NRS and related to the last 24 hours, due to the cancer, requiring OXN for the first time;
* With life expectancy \> one month;
* Strong opioid naïve;
* Eligible to take any of the medications under evaluation;
* With age ≥ 18 years.

Exclusion Criteria:

* With presence of other diseases, including psychiatric/mental illness, severe senile or other form of dementia, that can interfere with participation and compliance with the study protocol or can contraindicate the use of the investigational drugs;
* Diagnosis of primary brain tumor or leukaemia;
* Diagnosis of chronic renal failure;
* Patients with antalgic radiotherapy or radio-metabolic therapy in progress or completed less than 14 days before study;
* Patients starting a first line chemotherapy simultaneously to the beginning of the study;
* Other types of analgesic treatments, including local-regional anesthetic techniques or neurosurgical /ablative methods;
* Patients who cannot guarantee regular follow-up visits for logistic or geographic reasons.
Sarcopenia in COPD Patients: a French Study

The prevalence of sarcopenia is high in many organ pathologies such as COPD, but remains little studied in acute respiratory failure. Sarcopenia is a health problem representative of frailty, loss of autonomy and decreased muscle strength. The frequency and evolution of sarcopenia is unknown in patients having chronic bronchic obstruction with exacerbation.

* Investigator consecutively included patients with known persistent airflow obstruction, hospitalized in Pneumology Department at the CHU Gabriel Montpied in Clermont-Ferrand.
* Investigator offered to participate to an observational study involving nutritional evaluation (recommended by national and international authorities) complementary to their usual respiratory care, and a 6 months' follow-up consultation: examination and surveys, mid-arm muscle circumference, body composition, spirometry.
* This enables to assess sarcopenia as a low mid-arm muscle area, by measuring the mid-arm muscle circumference of the dominant side and the triceps skinfold thickness.
* The primary endpoint is to determine the prevalence of sarcopenia, via the brachial muscular circumference, of chronic obstructive patients hospitalized in Pneumology department.
* The data entry (clinical, biological and radiological) is carried out on site, during the initial consultation and follow-up, directly on the computerized patient file. These data will then be retrieved and entered in an Excel spreadsheet, anonymously (anonymous identification number, gender and age).
* Management of censored data (lost to follow-up, cessation or withdrawal of study): each patient has a "computerized patient record" with phone numbers, checked during the first consultation and updated if necessary. The patient is called back one month before the follow-up consultation to confirm the appointment. If it is impossible to come, the patient will be offered another appointment, within one month of his initial appointment.
* Lost participants will not be excluded from statistical analyses.
* The expected number of subjects is 50.
* Oral and written consent is asked at the beginning of the consultation proposing participation in the study and follow-up at 6 months.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years
* A history of persistent airflow obstruction (a post-bronchodilator FEV1/FVC \< 0.7 of the predicted value after 400 ug of inhaled salbutamol) compatible with respiratory function tests (according to the GOLD definition)
* Informed consent to examination of nutritional status

Exclusion Criteria:

* Bronchopulmonary cancer being treated
* Disabling rheumatic disease
* Recent stroke or surgery (\< 3 months)
* Missing data on essential variables (BMI, mid-arm muscle circumference)
Shock Wave Lithotripsy Versus Visual Cystolitholapaxy in The Management of Patients Presenting With Calcular Acute Urinary Retention: A Randomized Controlled Trial.

The aim of the study is to compare the safety and efficacy of ESWL and visual cystolitholapaxy in management of calcular acute urine retention.

Patients who present with acute urinary retention due to stone in the urethra or urinary bladder will be randomly assigned to receive treatment either by extracorporeal shock wave lithotripsy or by endoscopic visual cystolitholapaxy where patients and stone characteristics will be recorded and the outcome including the intraoperative and postoperative complications and the stone free rate will be also evaluated

Eligibility Criteria:
Inclusion Criteria:

1. Adult male patients presenting with acute urinary retention due to urethral or urinary bladder stones.
2. with a stone size not more than 2 centimeters in greatest diameter.
3. No more than 2 stones.

Exclusion Criteria:

1. Bladder cancer.
2. Bladder replacement of any type.
3. Infravesical obstruction, due to marked benign prostatic hyperplasia, prostate cancer, stricture urethra or external urethral meatal stenosis.
A Brief Case Management Intervention for People Involuntarily Admitted to a Psychiatric Hospital

The goal of this clinical trial is to assess whether a brief case management intervention aimed at promoting personal recovery and reducing the negative effects of coercion among people involuntarily admitted to a psychiatric hospital would be well accepted by them, practically feasible and useful. The main questions it aims to answer are:

* Is the case management intervention acceptable and feasible?
* What are the preliminary effects of the case management intervention on patients' personal recovery and its sub-dimensions, as well as on their level of perceived coercion and their global satisfaction with hospital care?

Participants will be asked to take part in:

* the five sessions of the case management intervention;
* two evaluation sessions (pre and post-intervention);
* a final in-depth semi-structured interview (optional).


Eligibility Criteria:
Inclusion Criteria:

* To have been involuntarily admitted by a medical doctor
* To be aged between 18 and 65 years

Exclusion Criteria:

* Patients unable to provide written consent due to a lack of discernment
* Patients unable to speak French well enough to participate in the study without the help of an interpreter
Acute Effects of Kinesiology Taping in Handball Players

The aim of this randomised placebo-controlled study was to investigate the acute effect of kinesiology taping in the gastro-soleus muscle group of handball players.

Researchers compared the placebo and the kinesiology taping groups to see if there were any effects on foot plantar and dorsiflexion muscle strength, balance, proprioception, horizontal jumping and injury proneness.

This randomised placebo-controlled and double blinded study aimed to investigate the acute effect of kinesiology taping in the gastro-soleus muscle group, which has the key role in jumping, of handball players on foot plantar and dorsiflexion muscle strength, balance, proprioception, horizontal jumping and injury proneness. There were two groups in the study: the experimental group was applied 'Y shaped' kinesiology taping on gastro-soleus muscle group, based on facilitation technique with 25-50% stretching. The control (placebo) group was applied kinesiology taping on gastro-soleus muscle group without any stretching. Participants' muscle strength, proprioception, balance, horizontal jumping and injury proneness was measured before and two hours after taping.

Eligibility Criteria:
Inclusion Criteria:

* Licensed handball player
* Volunteer to participate the study

Exclusion Criteria:

* Any discomfort that is contraindicated for the measurements
* Have suffered any injury in the last 6 months
Identification of Spine Structures by Using BIP-Needles

The main purpose of the study is to assess the feasibility and clinical performance of impedance based tissue identification in various spine structures.


Eligibility Criteria:
Inclusion Criteria:

* Voluntary adult patients going through medical operation involving spinal puncture, spinal fluid sampling or intrathecal drug injection.

Exclusion Criteria:

* Participation to other clinical study
* Exclusion criteria are the same as generally for spinal anaesthesia and lumbar punctures. Exclusion criteria includes infection on skin area, systemic anticoagulation, sepsis, anatomical unsuitability and refusal
* In addition for not giving (or not capable to give) the consent personally for any reason is an absolute exclusion criterion. In practice this means that study is for adult patients only.
Health-related Quality of Life and Comorbidities in Danish Patients With Idiopathic Pulmonary Fibrosis - a Nationwide Follow-up

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a high mortality. Health-related quality of life (HRQL) is impaired in patients with IPF. Little is known about the properties of recently developed HRQL questionnaires and about the longitudinal changes in HRQL, including factors with an impact on HRQL. Comorbidities have an impact on patients with IPF, but reports differ in incidence and prevalence. The impact of comorbidities on HRQL and disease progression has only been studied sparsely. Also, the association between biomarkers and disease progression need to be examined further.


Eligibility Criteria:
Inclusion Criteria:

1. A clinical diagnosis of IPF
2. Signed informed consent

Exclusion Criteria:

1. Clinical, radiological or histological findings inconsistent with a diagnosis of IPF
2. Inability or unwillingness to adhere to the study
3. Active on lung transplantation list
Influence of Environmental Conditions on In Vitro Fertilization (IVF) Attempts and Induced Pregnancies

The main purpose of the study is to assess the impact of environmental conditions on live-birth rates after intraconjugal IVF.

The second purposes are

* to assess the impact on pregnancies (prematurity, preeclampsia);
* to assess the impact on newborn's health (stunted growth);
* to evaluate the consistency of results observed between assisted pregnancies and spontaneous pregnancies.

This multicenter epidemiological study aims to analyze the individual standardized clinical records, collected prospectively since 2008 in the medically assisted procreation centers (MAP).

These individual data will be mapped to the environmental data (meteorological and air quality), recorded in the area of residence of the mother at the time of conception and pregnancy, as well as to the socio-economic data.

Choice of centers:

* The study will be proposed to the 106 private or public centers in metropolitan France who are authorized for MAP procedures such as IVF and ICSI.
* Only the centers who perform more than 200 oocyte retrievals per year will be selected to participate in the study.

More than 80% of attempts performed by the selected centers should be available (without missing data) on the induced pregnancies and their outcome (minimum data set for each case: age of man and woman, cause of infertility, technique used, sperm collection method (ejaculation, surgical sperm retrieval techniques), total number of embryos obtained, clinical pregnancy or not, term of pregnancy, weight and height of the child at birth).

Eligibility Criteria:
Inclusion Criteria:

* Intraconjugal IVF and ICSI
* Transfers of frozen embryos after intraconjugal IVF or ICSI

Exclusion Criteria:

* IVF and ICSI with sperm donation
* IVF and ICSI with egg donation
CO2 Laser in the Treatment of the GSM - (Genitourinary Syndrome of Menopause) Genitourinary Syndrome of Menopause

Menopause is a woman's hormonal status one year after her ovulatory failure, when the decrease of circulating estrogen levels leads to a group of symptoms named Genitourinary Syndrome of Menopause (GSM), such as: vaginal dryness, dyspareunia, dysuria, epithelial fragility with recurrent bleedings, loss of genital elasticity and pH alterations causing recurrent infections. The CO2 laser is a fractional ablative source of light, capable of inducing neocollagenesis within the skin, reversing atrophies, increasing blood supply and reorganizing the architectural structure of the treated epithelium. Recent studies in the laser field show great improvement of the SGM, with satisfying results in female's sexual disfunction. Nevertheless, there is still a lack of studies that show, at the same time, the improvement in both patient's subjective reports and objective measurements, such as cytology, histology and immunohistochemistry. This study aims to thoroughly analyze the benefits of the CO2 laser in the treatment of the GMS, comparing the improvement found in questionnaires to the results of cytology, histology and immunohistochemistry for collagen I and III from vaginal biopsies before and after the laser treatment. Therefore, fourteen women after menopause complaining of symptoms of the GSM were selected from the ambulatory of the Hospital Universitário Antônio Pedro. The patients will be submitted to three CO2 intravaginal laser (Femilift®), with a 30-days interval between them. Biopsies of the vaginal wall will be taken one month before the start and one month after the end of the laser sessions, and material will be sent to histology, cytology and immunohistochemistry analysis. Results obtained will be compared to the patients' reports, in order to evaluate subjective and objective improvement due to the treatment.


Eligibility Criteria:
Inclusion Criteria:

* Women from 40 to 70 years old;
* Post- menopausa (at least one year after cessation of periods);
* Experimenting any symptom related to the Genitourinary Syndrome of Menopause (GSM), such as: vaginal dryness, dyspareunia, urinary incontinence, dysuria, recurrent urinary infections;
* Regular follow up in gynecologist, with recent normal pap smear.

Exclusion Criteria:

* The volunteers must not be under any treatment for this syndrome;
* Volunteers cannot be using hormones or any vaginal treatment;
* Volunteers cannot have previous history of vaginal / uterine cancer;
* Volunteers cannot have previous surgery for urinary incontinence;
* Uterine prolapse;
* Recent altered pap smear.
Causes of Low Digestive Bleeding in Proctology

The various causes of bleeding Proctological are well known to gastroenterologists in clinical practice but their proportions have not, to our knowledge, been dedicated epidemiological studies. Investigators wanted to evaluate this data as part of a specialized consultation. Investigators have prospectively collected the causes of gastrointestinal bleeding down the patients seen two of us in specialized proctology center. A clinical examination including an inspection, palpation and feel, and a anoscopy (when possible) were made during the consultation. Local levies referred (s) histological and / or infection were also carried out if necessary. When she had not been made, a colonic exploration was offered to all patients over 45 years and / or when indicated by the pathological context. When there were several possible causes, the clinician holding one that seemed to be the main. Patients consulting within four months postoperatively a proctology action were not included. The study period extended from September 2013 to July 2014 inclusive. The collection of anonymous data.

The various causes of bleeding Proctological are well known to gastroenterologists in clinical practice but their proportions have not, to our knowledge, been dedicated epidemiological studies. Investigators wanted to evaluate this data as part of a specialized consultation. Investigators have prospectively collected the causes of gastrointestinal bleeding down the patients seen two of us in specialized proctology center. A clinical examination including an inspection, palpation and feel, and a anoscopy (when possible) were made during the consultation. Local levies referred (s) histological and / or infection were also carried out if necessary. When she had not been made, a colonic exploration was offered to all patients over 45 years and / or when indicated by the pathological context. When there were several possible causes, the clinician holding one that seemed to be the main. Patients consulting within four months postoperatively a proctology action were not included. The study period extended from September 2013 to July 2014 inclusive. The collection of anonymous data.

Eligibility Criteria:
Inclusion Criteria:

* All patients with proctological context

Exclusion Criteria:

* Patients refusing to participate