cyrilzakka/clinical-trials huggingface dataset:
Spinal Mepivicaine With Fentanyl for Outpatient Knee Arthroscopy

The purpose of this study is to determine if the addition of intrathecal fentanyl to low dose mepivacaine spinal anesthesia provides adequate surgical anesthesia with shorter duration of motor blockade.

It is hypothesized that lower doses of spinal mepivacaine when combined with fentanyl will result in adequate surgical block for knee arthroscopy surgery with faster recovery and discharge compared to mepivacaine alone.


Eligibility Criteria:
Inclusion Criteria:

1. Patients having unilateral arthroscopic surgery of the knee;
2. ASA I-III status;
3. Age 18-80 years;
4. BMI\< 35.

Exclusion Criteria:

1. Patients who have previous history of hypersensitivity to local anesthetics or contraindications for spinal anesthesia (i.e. bleeding diathesis, coagulopathy);
2. Patients with radiating low back pain and neurological deficits in lower extremities;
3. Patients who are incapable of giving an informed consent.
Cetuximab Plus P-HDFL for the First-line Treatment of Advanced Gastric Cancer

The investigators have initial evidence that the combination of cetuximab and cisplatin-HDFL may further improve the efficacy of the cisplatin-HDFL combination chemotherapy.

The clinical efficacy (confirmed objective response rates, progression-free survival, overall survival), and treatment-related toxicities of this novel regimen will be examined as the first-line treatment in patients with nonresectable or recurrent/metastatic gastric cancer.

Eligibility Criteria:
Inclusion Criteria:

1. Age 18 to 75 years
2. Histologically proven adenocarcinoma
3. At least one "measurable" lesion (by RECIST)
4. No prior chemotherapy for gastric cancer
5. WHO performance status ≦ 2
6. Adequate baseline organ functions
7. Fasting serum triglyceride level \> 70 mg/dL
8. Written informed consent
9. At least one month from gastrectomy
10. Availability of tumor sample for immunohistochemical or pharmacogenomic testing of EGFR

Exclusion Criteria:

1. Concomitant anti-cancer biological agents, chemotherapy, or radiotherapy
2. CNS metastasis
3. Pregnancy, breast-feeding women and women of child-bearing potential
4. Life expectancy less 3 months
5. Serious concomitant illness
6. Concurrent or prior second malignancy
7. Known hypersensitivity reaction to any of the components of study treatments
Follicular Size and Ploidy Observational Study

The primary objective is to determine which follicle sizes generate the highest rate of euploid blastocysts.

The primary objective is to determine which follicle sizes generate the highest rate of euploid blastocysts.

Secondary objectives to be analysed between the different follicle sizes:

* The number of cumulus oocyte complexes (COCs) retrieved per aspirated follicle size
* The number of mature oocytes per COC retrieved (maturation rate)
* The number of normally fertilized oocytes per number of oocytes injected (fertilization rate)
* Embryo development up to the blastocyst stage
* Chromosomal status of the biopsied blastocysts
* Pregnancy rates after euploid blastocyst transfer
* Miscarriage rate after euploid blastocyst transfer

Most of the studies that looked at the relation between the follicular size and the developmental competence of the corresponding oocyte analysed normal responders with an average age of 35 years and normal BMI levels. However, during the last decades, a clear shift appeared in the patient population that present themselves for a fertility treatment. With many women delaying childbirth, we do not yet know how these advanced maternal age women may benefit from early or late trigger or from different follicular sizes.

Also, the rising prevalence of obesity may impact the follicular growth, which has not been analysed at the individual follicle size before.

For the above described reasons, we believe that the analysis of individual follicles and the developmental competence of the obtained oocyte, may guide us to improve individualized stimulation protocols for different subtypes of infertile patients. To guide us in this individualized process, this initial pilot study will be performed in a population of normal responders and will later be expanded to an infertile population with different characteristics.

Eligibility Criteria:
Inclusion Criteria:

Cycles with PGT-A analysis

* ICSI (intracytoplasmic sperm injection) only
* ICSI 40 hours after trigger
* Fresh oocytes
* Ejaculates: fresh or frozen: normozoospermia
* BMI ≤ 35kg/m 2
* Age ≤ 40 years
* AMH ≥ 1.1 ng/ml
* the number of follicles at the day of trigger: max 20 ≥ 11mm
* Stimulation protocol: Antagonist protocol with Menopur and and Dual trigger of (5.000-10.000IU) hCG and (0.2-0.3 mg) Gonapeptyl
* Final oocyte maturation trigger when 2-3 follicles reach size 17mm
* All races
* Embryo development in the Embryoscope with Global Total media

Exclusion Criteria:

* Inability to puncture all follicles from one ovary
* Endometriosis
* Hydrosalpinx
* History of uterine surgery
* History of previous treatment which may impact the ovarian reserve (adnexal surgery,
* chemotherapy, radiation...)
* Time between trigger and pick up deviating from 36 hours
* \< 100.000 motile sperm
* Last follicular measurement day deviates more than 24 hours from the trigger day
Biocriminology and the Adjudication of Criminal Responsibility: Is There a Consensus Among Scientists' Verdicts?

Because of the evolving nature of psychology research, non-scientists are more likely to struggle or misinterpret evidence regarding a person's psychological state. Misconceptions may thus be highly prevalent within the justice system, leading to negative consequences for people with psychological or neurobiological disorders. At the same time, no research has been conducted to compare the punishment perspectives of non-scientists, that typically make sentencing decisions, to scientists who possess a more advanced understanding of human biology and behavior.

In this study, closely inspired by the paradigms of Berryessa, Coppola, and Salvato, perspectives on punishment based on psychobiological explanations of behaviour are assessed, aiming to understand how scientists with knowledge of human psychobiology versus lay people (of similar educational level) interpret offending behaviour. Human-science is contrasted to natural-science/arts graduates because the former have been exposed to and may possess scientific knowledge that shapes their understanding of behaviour, their views, and potential (essentialist) biases. In contrast, non-scientists have been found to possess scientific misconceptions that can impact their sentencing decisions. This leads to the question whether scientists may draw different judgements based on their professional knowledge and experience with psychological phenomena. If indeed scientists with greater insight on human behaviour are found to hold less punitive views on punishment and rehabilitation, that has important implications for criminal justice systems that rely on lay peoples' understanding of science.

One hundred sixty participants who completed all study procedures (2 main groups of 80 participants) will be surveyed. A sample size calculation was performed using G\*Power version 3.1.9.4, based on Berryessa and colleagues who conducted a similar survey study in 2021 with comparable outcome measures and analyses. The required effect size is based upon approximately 3-4 outcome measures. The primary research question is between-groups, while secondary ones include within groups measures. Based on the power analysis, a sample of 160 participants will be targeted, which is enough for sufficient power for f = 0.25, power = 0.80, df = 4, for 2 different groups.

Eligibility Criteria:
Inclusion Criteria:

* Aged between 18 and 65
* Holding a university diploma or equivalent

Exclusion Criteria:

* Participants who did not complete the survey (appropriately) will be excluded
Maternal-foetal Transmission of SARS-Cov-2

One case of maternal-fetal transmission of SARS Cov-2 was published (1). Ig M and Ig G were found at two hours after birth of a new born from a mother COVID-19. Another study on few newborns COVID-19 reported that the SARS-Cov-2 was not transmitted in utero but only after birth.

Although there are few data on COVID-19 during pregnancy, according to our national data collections, it appears to be responsible for miscarriages and fetal deaths. There are also intrauterine growth restrictions and an increase of the rate of cesarean sections for maternal indications. Therefore, it is essential to know if there is a maternal viremia which infects the fetus because the consequences in terms of management would be completely different.

In fact, the potential intrauterine infection will lead to antenatal monitoring of these patients with an antenatal diagnosis and may be a treatment.

Therefore, it seems essential to explore the mode of transmission to the newborn since many newborns have COVID-19 infection The investigators will propose to all pregnant women SARS- Cov-2 positive to perform PCR SARS-Cov-2 tests and /or serology's (IgM and Ig G) on the amniotic fluid, the blood cord and the placenta.

Pregnant women SARS cov-2 positives during pregnancy or during labor tested by a RT-PCR SARS-Cov-2 on nasopharyngeal swabs and/or by serologies.

After informed consent the ivestigators will proceed during labor to:

1. A vaginal swab of amniotic fluid during the rupture of the water pocket during labor.
2. a blood sample from the umbilical cord after delivery of the newborn and clamping and sectioning of the cord. PCR Covid-19 and serologies (Ig M and Ig G) as well as investigating viral proteome and cytokines.

   These are additional samples in addition to the routine samples which have no impact and without risk for the mother the newborn since they are taken after delivery from the side of the placenta after clamping and sectioning of the cord.
3. Samples of 2 fragments of placenta after delivery of the placenta for COVID-19 research, which usually goes to waste or to pathology depending on the clinical context or for infectious tests. In all cases, samples of 3 to 4 cm3 will be taken which will in no way interfere with current analyzes carried out on the placenta which weighs one third of the fetal weight on average. A viral search by COVID-19 PCR will be carried out on the placenta fragment and another part will be frozen for analysis by electron microscopy and study of the viral proteome, cytokines and immune mechanisms. Placenta samples will be frozen at -80 degrees.

Eligibility Criteria:
Inclusion Criteria:

* All pregnant women SARS-Cov-2 positive during the pregnancy
* Informed consent obtained
* 18 years to 48 years

Exclusion Criteria:

* Pregnant women without SARS-Cov-2 infection ( PCR test and or serologies negatives)
* curatorship patients.
* Refusal to participate to the study
Effects of Rhythmic Auditory Cueing Augments Cognitive Treadmill Walking Training in Individuals With Chronic Stroke

The first objective of this study is to examine the superiority of the combined rhythmic auditory cueing with cognitive treadmill training (combined group) in people with stroke as compared with the cognitive treadmill walking training (cognitive group) or treadmill walking training alone (treadmill group) (Aim 1). The study's second aim is to investigate the factors affecting the improvement in community walking capacity after interventions and to explore whether changes in community walking capacity are associated with changes in participation after interventions (Aim 2).

A single-blind, randomized controlled trial is conducted at medical centers. Ninety stroke patients will be randomized to one of the three groups. All groups will receive interventions 30 minutes per time, 3 times a week, for 4 weeks. The combined group will undertake progressive treadmill walking speed while performing a cognitive task with rhythmic auditory cueing (i.e., 110% of baseline cadence). The cognitive group will receive cognitive training while walking at a progressive speed on the treadmill. The treadmill-alone group will train only in treadmill walking with progressive speed adjusted weekly. A blinded assessor will administer three assessments. All participants will be examined for gait and cognitive performance under single-task (walking only, Stroop task only) and dual-task conditions (walking while performing the Stroop task) at baseline, post-intervention, and one-month follow-up. The primary outcome measures are gait and cognition under single- and dual-task conditions. The secondary outcome measures are the 6-minute Walk Test, Mini-BESTest, Stroke Impact Scale, and Walking Ability Questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* diagnosed with first-time stroke;
* more than 6 months after stroke onset;
* able to walk 10 meters;
* no severe vision, hearing, or speech impairments;
* understand and follow the instructions and sign the Informed Consent Form;
* older than 20 years old.

Exclusion Criteria:

* orthopedic problems affecting walking or other diseases that may interfere with study participation;
* a score of less than 24 on the mini-mental state examination (MMSE);
* severe balance disorder with a total score of less than 45 points Berg Balance Scale.
Musical Attention Control and Executive Function Training for Adults with MDD

The investigators have developed music-based cognitive training sessions derived from Neurologic Music Therapy (NMT) techniques. The music-based cognitive training sessions will address areas of attention and executive function, which appear to progress over time and worsen as an individual experiences more episodes of depression. The aim of this pilot is to test 8-weeks of music-based cognitive training to improve cognitive function among adults with major depressive disorder.

Major Depressive Disorder (MDD) is a lifelong condition and is the leading cause of disability in the world. MDD is a multifaceted mood disorder and due to its complex nature, this mental health diagnosis affects emotional, behavioural, and cognitive processing. Cognitive dysfunction appears to progress over time and worsens as the individual experiences more episodes of depression. Because of this, it is critical to continue to investigate and formulate effective treatment that can target and improve not only depressive symptoms, but also address overall cognitive function. Thus, the investigators propose implementing music-based cognitive training derived from Neurologic Music Therapy (NMT) techniques to address cognitive dysfunction experienced by adults diagnosed with MDD. Music-based interventions, specifically from the NMT approach have been shown to physically change the human brain when working on cognition in areas of attention and executive function, however little is known of these applications with adults with MDD. The aim of this pilot is to test 8-weeks of music-based cognitive training to improve cognitive function among adults with MDD.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of MDD meeting the Diagnostic and Statistical Manual Diploma in Social Medicine (DSM-V) criteria
* Experiencing suicidal ideation in the past week (Beck Scale for Suicide Ideation \>10)
* Have received more than 12 sessions of psychotherapy
* Stable medication use \> 4 weeks
* Ability to undergo music-based cognitive training sessions in English
* Capable of giving informed consent

Exclusion Criteria:

* The presence of cognitive impairment that would limit consent or understanding of neurologic music therapy
* The presence of active psychosis
* The presence of mood and suicidal symptom severity requiring immediate treatment
* Hearing impairment
* Participation in music therapy 6 months prior to study
* Private music lessons for a period of 1 year prior to study
* Unwilling or unable to provide informed consent
Examining the Effects of Art Therapy in Reducing Burnout in Healthcare Providers

In this study, the investigators aim to examine the effects of art therapy in reducing burnout in healthcare providers. Using the Maslach Burnout Inventory Human Services Survey for Medical Personnel, the investigators will measure burnout in Medical University of South Carolina (MUSC) providers before and after the administration of a 4-week art therapy group.


Eligibility Criteria:
Inclusion Criteria:

* Age: 18 years or older
* Employed at MUSC as a healthcare provider
* Able and willing to participate in all 4 art therapy sessions

Exclusion Criteria:

* Individual does not provide direct patient care at MUSC
* Individual works in the same department as the art therapist
* Inability or unwillingness of subject to give informed consent
Product Surveillance Registry; Ear, Nose &amp; Throat - NIM Vital Cohort

The purpose of this study is to confirm clinical safety and performance of Medtronic's NIM Vital™ System and accessories when used as intended in a real-world setting.

Ongoing clinical investigation for the purpose(s) of:

* Providing continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products for their intended use
* Obtaining real-world performance and safety information from a global network of hospitals, clinics, and clinicians intended to represent the range of clinical environments in which Medtronic products are used
* Supporting post-market surveillance activities and post-approval studies that are initiated by Medtronic, regulated by local governments, or are conducted to fulfill government and/ or regulatory authority requests
* Obtaining clinical evidence to guide the development and improvement of medical devices, therapies, device guidelines, and patient services/solutions
* Providing clinical data to support health economics and clinical outcomes research

Enrollment for this study is ambispective, and subjects can be enrolled up to 60 days before or after the baseline procedure. There is no scheduled follow-up visit, however, if a reportable event occurs, patients will be followed until resolution or up to 6 months following the procedure. Total duration for study participants is anticipated to be 1 visit.

Eligibility Criteria:
Inclusion Criteria:

* Patient or legally authorized representative (LAR) provides authorization and/or consent per institution and geographical requirements.
* Patient has or is intended to receive or be treated with an eligible Medtronic product
* Patient is consented within the enrollment window of the therapy received, as applicable

Exclusion Criteria:

* Patient who is, or is expected to be, inaccessible for follow-up
* Participation is excluded by local law
* Patient is currently enrolled or plans to enroll in concurrent drug/device study that may confound the PSR results
Obstetrical Risk Factors for the Development of Urinary and/or Fecal Incontinence

Evaluation of Obstetrical Risk Factors for the development of Urinary and/or Fecal Incontinence according to a questionaire

The questionaire will be filled by the study investigators after the women participating in the study sign their consent. The study is based solely on a questionaire and does not include any physical examination, blood exam or intervention.

The study will be performed on the premises of Maaynei Hayeshua medical center. The inclusion criteria include women above the age of 18 who arrive to Maaynei Hayeshua Medical center for any reason. The data will be transferred to a computerized data base and analyzed statistically.


Eligibility Criteria:
Inclusion Criteria:

* women of age 18 or above

Exclusion Criteria:

* women under the age of 18
* men
Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors

While neurocognitive impairments in attention, memory and executive functioning are commonly reported sequelae of childhood leukemia and brain tumors, studies have only recently begun to examine the treatment of attention deficits in this population. Numerous studies have examined the effectiveness of methylphenidate in the treatment of children with attention deficit hyperactivity disorder (ADHD). However, the effectiveness of this medication for improving attention and behavioral functioning in children with medical illnesses or brain injury are less clear.

Patients will be randomized to receive one week of Metadate CD (a controlled release form of methylphenidate, similar to Ritalin) and one week of placebo in a double-blind fashion.


Eligibility Criteria:
Inclusion Criteria:

Initial Screening and Registration

* Previous diagnosis of acute lymphoblastic leukemia or brain tumor and have been off treatment and in disease-free remission for a minimum of one year; treated at the University of Minnesota Medical Center, Fairview.
* Proficient in English
* Have given informed consent (assent)

After Initial Screening

* Have evidence of attention impairment based on parent report of attention deficit (\> and = 75% on attention deficit hyperactivity disorder \[ADHD\] Index, Hyperactivity, or Cognitive-Problems/Inattention Index of parent-completed attention deficit hyperactivity disorder (ADHD) rating scale \[Conners Parent Rating Scale\] and perform at least 1.0 standard deviations below the mean on Omissions, Commissions, or Variability indexes of the Test of Variables of Attention (TOVA)
* Have an estimated Full Scale IQ score on the Wechsler Abbreviated Scale of Intelligence (WASI) \>55.

Exclusion Criteria:

* Have optic pathway gliomas and/or neurofibromatosis
* Diagnosed with ADD/ADHD prior to their cancer diagnosis
* Currently taking antidepressants or antipsychotics
* Currently being treated with stimulant medication
* Blind
* Have glaucoma
* Have a family or personal history of motor or phonic tics or Tourette syndrome
* Have seizures not controlled by antiepileptic drugs
* Taking an MAO-inhibitor
* Have a history of cardiovascular disease, uncontrolled hypertension, or hyperthyroidism, or current hypertension requiring antihypertensives
Research Study on the Effects of Smoking on Arteries

The current proposal, will elucidate the role of oxidant stress (OS) on arterial function as measured by flow mediated vasodilation. In addition, the investigators will address the hypothesis, that a pro-oxidant might have different degrees of effects on different biological targets, by performing quantitative assessment of the effects of OS on lipids, proteins and DNA.


Eligibility Criteria:
Inclusion Criteria:

* Chronic smokers (of between 4 and 20 years duration) and non-smokers will be recruited to the GCRC. Smokers will be allocated to a "light" group, smoking 4-10 cigarettes per day and a "heavy" smoking group who smoke 11-20 cigarettes per day.
* Non-smokers will be defined as those with a life time consumption of no more than 20 cigarettes, do not live or work in a smoky atmosphere.
* All individuals will have a normal history and clinical examination, including a normal EKG, urinalysis and serum chemistry, haemogram and negative urinary pregnancy test.

Exclusion Criteria:

* previously suffered an acute major cardiovascular event
* those with a chronic disease
* those taking chronic medication
* those with a history of alcoholism or substance abuse
* Ex-smokers
* Subjects, who have less than or equal to 60% platelet aggregation in response to arachidonic acid