cyrilzakka/clinical-trials huggingface dataset:
Evaluation Of A Novel Breast Compression Paddle For Wire Localization In Mammography

The purpose of this study is to evaluate the functionality of a new breast compression paddle used in mammography for wire localization.

Presently, the breast compression paddles that are used in mammography for wire localization are made of plastic and contain a relatively small rectangular shaped opening through which the wire is placed in the breast. When technologists use this paddle, they must carefully position the breast such that the rectangular opening is above the region for wire localization. A novel paddle has been developed which increases the wire localization access area tremendously and should therefore make it easier to perform the procedure. The purpose of this study is to evaluate the functionality of this new compression paddle. The new compression paddle was developed by Biomedical Engineering students in conjunction with Radiologists and a Medical Physicist at the University of Michigan. It was designed and manufactured for a student project in the Mechanical Engineering 450/599 course at the University of Michigan.

Eligibility Criteria:
Inclusion Criteria:

* Women who are scheduled to undergo a wire localization procedure on the digital mammography unit at the University of Michigan Cancer Center

Exclusion Criteria:

* Men
* Pregnant Women
* Lactating Women
* Prisoners
* Children under the age of 18
* Mentally impaired individuals
EFFECT of PHYSIOTHERAPY in STROKE

The study was aimed to determine the volumetric change in the corpus callosum after the rehabilitation program in patients with stroke. A total of 42 patients (22 males, 20 females), 21 right hemiplegic and 21 left hemiplegic patients with unilateral hemiplegia were enrolled in the rehabilitation program. Traditional physiotherapy treatment was applied 5 days in a week, 1 hour in a day for 6 weeks. The corpus callosum volumes were measured and evaluated on Magnetic Resonance Imaging (MRI) images before and after the treatment.

Physical therapy after stroke contributes to the physical and social recovery of the paralyzed person. Corpus callosum is the commissural fibers consisting of white matter connecting the cortical areas between hemispheres. Its main function is to provide information exchange and coordination by establishing interhemispheric connections between areas in the right and left hemispheres. Inactivity and decreased physical activity may cause a decrease in the volume of the corpus callosum in patients with stroke. It was aimed to determine the volumetric change in the corpus callosum after the rehabilitation program in patients with stroke. A total of 42 patients (22 males, 20 females), 21 right hemiplegic and 21 left hemiplegic patients with unilateral hemiplegia were enrolled in the rehabilitation program. Traditional physiotherapy treatment was applied 5 days in a week, 1 hour in a day for 6 weeks. The corpus callosum volumes were measured and evaluated on Magnetic Resonance Imaging (MRI) images before and after the treatment.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with stroke
* Patients had unilateral hemiplegia
* Patients practiced a rehabilitation program at the Physical Medicine and Rehabilitation

Exclusion Criteria:

* Patients had other neurological disease
* Patients had mental disorders
The Effect of Rectangular Versus Square Archwire on Maxillary Canine Retraction

The Effect of Rectangular Versus Square Archwire on Maxillary Canine Retraction

his split-mouth randomized clinical trial will be carried out to evaluate the effect of rectangular versus square archwire on maxillary canine retraction.

Eligibility Criteria:
Inclusion Criteria:

- Individuals in permanent dentition phase with Class II canine and molar relationship that requires extraction of maxillary first premolars.

Individuals that require absolute anchorage using mini-implant.

No previous orthodontic treatment.

Good oral health

Age: 16-22 years

Exclusion Criteria:

- Patients with skeletal asymmetries.

Patients with syndromes or dental anomalies.

Patients with previous orthodontic treatment.

Evidence of root resorption.

Any medication affecting orthodontic tooth movement.
Metacognitive Beliefs in Adolescents With Eating and Nutrition Disorders

The present study aims to study the presence of metacognitive beliefs in adolescent subjects with eating and nutrition disorders (END) compared with a control group composed of subjects of the same sex and age belonging to the general population.


Eligibility Criteria:
Eating and nutrition disorders (END)

Inclusion Criteria:

* Female sex
* Age: 12 to 17 years
* Italian nationality
* Diagnosis relating to the END framework according to the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).

Exclusion Criteria:

* Absence of signed Informed Consent

Control group

Inclusion Criteria:

* Female sex
* Age: 12 to 17 years
* Italian nationality

Exclusion Criteria:

* Absence of signed Informed Consent
Comparison of Three Corneal Horizontal Marking Techniques Using iTrace™

Before astigmatism reducing surgery, accurate corneal horizontal marking before surgery is important. Due to new corneal topographic method, iTrace™ surgical workstation, precise evaluation of corneal horizontal marking is available. In this study the investigators compared three known corneal horizontal making techniques and evaluate accuracy of each methods using iTrace™.


Eligibility Criteria:
Inclusion Criteria:

* Patients who were scheduled to have cataract surgery
* Age between 50 to 85 years

Exclusion Criteria:

* With an underlying corneal or conjunctival disorder
Treatment and Rehabilitation of Patients With Hip Arthroplasty to Regain Walk and Work Efficiency and Quality of Life

The aim of the study is to improve hospital treatment and rehabilitation of patients with hip arthroplasty to help the patients to regain functional ability in the shortest possible time, and reduce hospital and rehabilitation time to save costs for the patient and society.

Optimal reconstruction of the hip joint and the effect of an intensive physical training programme are compared to conventional rehabilitation programmes.


Eligibility Criteria:
Inclusion Criteria:

* Primary osteoarthritis
* Unilateral osteoarthritis
* Age below 65 yrs
* ASA group 1-2

Exclusion Criteria:

* Pregnancy
* Age below 18 yrs
* Cardiovascular disease
* Diseases in the musculoskeletal system that could influence on training
PREMAPIV : Intravesical Pressure Variation at Different Bladder Instillation Volumes in Newborn Children

Abdominal Compartment Syndrome (ASC) is defined by an Intra Abdominal Hypertension (IAH) associated with a new organ failure. The occurrence of this syndrome is not well known in infants. Preterm birth is frequently associated with gastrointestinal complications, particularly Necrotizing Enterocolitis. In this pathology it is likely that the intra abdominal pressure (IAP) increases and can participate in the occurrence of organ failures. Newborn, in particular with digestive malformation as diaphragmatic hernias, gastroschisis, could themselves be suffering from this syndrome. It would be interesting to make early diagnosis in order to optimize the management of these children. This requires reliable measurements methods and standards. Intravesical Pressure (IVP) is the most reliable validated indirect method to measure intra-abdominal pressure. In order to measure the IVP, the bladder must contain a minimum of liquid. However, using inappropriate volumes could give erroneous IAP readings. The optimal amount of saline to inject in older children, determined from pressure-volume curves study is 1 ml/kg. In preterm and term infants, this volume appear extremely low (e.g. 0 8cc if taking a child to 800 g). The question that arises is whether this quantity is sufficient to obtain reliable and reproducible measurements of IVP in preterm and term.


Eligibility Criteria:
Inclusion Criteria:

* Preterm or term newborn admitted in paediatric intensive care unit
* With an urethral catheter
* Consent signed by parents

Exclusion Criteria:

* Weight \> 4.5 kg
* Urinary tract or bladder pathology
Immediate Intra Uterine Isemination (IUI) Versus Expectant Management in Postoperative Endometriosis Patients

Is postoperative IUI better than expectant management in infertile endometriosis patients with good prognosis based on their EFI score? (A single centre randomised controlled trial).


Eligibility Criteria:
Inclusion Criteria:

* recent (\<6months) complete laparoscopic endometriosis resection
* endometriosis fertility index (EFI) at least 7/10
* Regular menstrual cycles (min 24days - max 38days) with proven ovulation
* At least one functional tube at surgery, normal uterus
* Sperm sample of partner: normal or mild male factor

Exclusion Criteria:

* frozen (donor or partner) sperm
* clinical and/or imaging evidence of endometriosis recurrence/persistence at randomization
* FSH \> 20 IU/L
Colombia National Porphyria Registry

porphyria is classified as a rare disease and is produced by defects in the enzymatic activity in the biosynthesis of the heme group that leads to the over-accumulation and excretion of porphyrin precursors in hepatocytes or erythroid cells, extrahepatic or extramedullary cells, tissue, and end-organ injury. Acute intermittent porphyria is the most common and severe form of hepatic porphyria, with an annual incidence of symptomatic patients of 0.13 per million people. Aim: characterization of cases of acute hepatic porphyria in Colombia. Methods: a descriptive pilot study of patients diagnosed with acute hepatic porphyria's in Colombia. Patients of all age groups with a confirmed diagnosis of acute hepatic porphyria. Patients with concomitant pathologies, as well as pregnant women, will also be included. Patients who refuse to participate in the study will be excluded. Expected results: describe the sociodemographic and clinical characteristics of patients with a diagnosis of acute hepatic porphyria, and encourage patients and/or representatives in the research agenda.

A cross-sectional descriptive observational study is carried out in adult patients diagnosed with HAP in Colombia, the incidence and prevalence were estimated, the clinical, socio-demographic and acute attack characteristics are described, and the health-related quality of life was evaluated with the SF-36 questionnaire.

Eligibility Criteria:
Inclusion Criteria: - Patients of all age groups with a confirmed diagnosis of acute hepatic porphyria with AT LEAST ONE OF THE FOLLOWING CHARACTERISTICS will be included:

* Acute symptoms consistent with disease and positive urine qualitative porphobilinogen or substantially elevated quantitative porphobilinogen.
* Acute symptoms compatible with the disease and decreased HMBS enzyme activity (less than 50%).
* Mutation in the genetic sequence of the HMBS gene.
* Confirmatory test that identifies the type of porphyria (analysis of total and fractionated porphyrins in urine, feces and plasma).

Patients with concomitant pathologies, as well as pregnant women, will also be included.

Exclusion criteria:

* Patients who refuse to participate in the study will be excluded.
Comparison of Sequential CFA vs CFA +rFSH for Elective Fertility Preservation.

This randomized was designed as non-inferiority trial aiming to compare the number of MII oocytes with 2-shot of Corifollitropin alpha (CFA) sequential administration: 150μg at stimulation day (SD) 1 and 100μg at SD 5 and 1-shot of CFA administration 150μg at SD 1 following by rFSH 200IU daily from SD 8 in women undergoing elective fertility preservation in a progestin-primed ovarian stimulation (PPOS) protocol and GnRH-agonist (GnRH-a) triggering.


Eligibility Criteria:
Inclusion Criteria:

* AFC ≤20
* Anti-Mullerian hormone (AMH) ≤3ng/ml (AMH result of up to one year will be valid)
* Between 18 and 40 years old
* BMI \>18 and \<30 kg/m2
* Body weight \> 50 kg for \> 36 years
* Able to come to the Center to comply with the procedures of the study: blood tests, appointments and drug dispensation.

Exclusion Criteria:

* Medically indicated fertility preservation
* AFC \> 20
* Polycystic ovarian syndrome (PCOS) according to the Rotterdam criteria
* FSH ≥ 20
* History of untreated autoimmune, endocrine or metabolic disorders
* Contraindication for hormonal treatment
* Recent history of severe disease requiring regular treatment (clinically significant concurrent medical condition that could compromise subject safety or interfered with the trial assessment).
EffectiveNess and SAfety of Small ANeurysm COiling Trial

To compare the safety and efficacy of treating small aneurysms with coils specially designed for small aneurysms to historically reported rates of safety and efficacy for the treatment of larger aneurysms.

This is a prospective cohort study whereby patients who undergo endovascular treatment with coils for intracranial aneurysms will be studied for initial procedural and 12-18 month post-treatment outcome. The procedural failure rate (defined above) of treating small aneurysms with specially designed coils will be compared to pre-specified historical occurrences. This evaluation will occur within the framework of "non-inferiority" (i.e. comparable success to coiling of large aneurysms).

Eligibility Criteria:
Inclusion Criteria:

* Patient presenting with a ruptured or un-ruptured cerebral aneurysm appropriate for endovascular treatment as determined by the neurovascular team (neurosurgeon/neurointerventionalist)
* Patients between (and including) 18 and 90 years of age.
* Patient HUNT AND HESS Grade 0-3.
* Where required, patient has given fully informed consent to endovascular coiling procedure. If patient cannot consent for themselves, appropriate written consent has been sought from their surrogate, or from appropriate power of attorney.
* Aneurysm \< 4mm in maximum diameter.
* Patient is willing and able to return for clinical evaluation and follow-up imaging evaluation (angiography or MRA) at both 6-months and 12-18 months after endovascular treatment.
* The aneurysm has not previously been treated (by coiling or clipping).
* A three-dimensional angiogram has been performed.
* Placement of at least one "Nano" coil, at, or at least close to the neck of the aneurysm.

Exclusion Criteria:

* Patient has more than one aneurysm requiring treatment in the current treatment session. If a patient has multiple aneurysms, but only one will be treated at the time of enrollment, they are eligible for the trial. (Additional aneurysms may be treated at a later date, and may be treated with any coil type that the operator chooses).
* Patient has an H\&H score of 4 or 5 after subarachnoid hemorrhage (SAH).
* Medical or surgical co-morbidity such that the patient's life expectancy is less than 1 year.
* Less than 80% by length of Stryker endovascular coils are implanted.
Construction and Application Plan of Home Cardiac Rehabilitation for Patients Undergoing TAVR

Cardiac rehabilitation is a long-term process, but patients have poor compliance with cardiac rehabilitation. The theory of behavior change rotation aims to comprehensively intervene from three aspects: ability, opportunity, and motivation, promoting individual behavior change by selecting the best intervention function and maximizing the use of available resources. To improve the compliance of TAVR patients with digital home cardiac rehabilitation, this study is based on the needs of TAVR patients and their caregivers for digital home cardiac rehabilitation. Based on the best evidence summary of TAVR patients' home cardiac rehabilitation, a home cardiac rehabilitation plan for TAVR patients is constructed using the theory of behavior change wheels. The Delphi method is used to revise the plan, develop a TAVR patient home cardiac rehabilitation management system, and conduct clinical application research on the plan to explore the intervention effect of TAVR patients' home cardiac rehabilitation based on real-time information intervention.

Conduct home cardiac rehabilitation assessment 1-6 days before discharge; In the first week after discharge, cultivate the patient's motivation for rehabilitation; In the second week after discharge, create a home rehabilitation environment; In the third week after discharge, health education on risk factor management; Health education on anticoagulation management in the fourth week after discharge; 5 weeks after discharge, home symptom and follow-up management education; Carry out home exercise and monitoring from 1 to 12 weeks after discharge.

Eligibility Criteria:
Inclusion Criteria: Patients undergoing TAVR who were classified as Grade I-III by the New York Heart Association (NYHA); Patients are able to use mobile devices such as smartphones; Patients who have obtained admission qualifications after undergoing digital home cardiac rehabilitation risk assessment by the rehabilitation team; The patient and their family members voluntarily participate in this study and are willing to provide an informed consent form; Able to use remote rehabilitation diagnosis and treatment systems Exclusion Criteria: Malignant tumors or those with serious complications; Patients with hearing and visual impairments; Patients with limited physical activity due to other diseases; Patients with obvious cognitive or mental disorders; Patients without Internet connection after returning home from hospital; Patients who have participated in or participated in other trials or rehabilitation plans within the past three months.
Implants Placement with Simultaneous Soft Tissue Augmentation Using a Collagen Matrix Compared to Connective Tissue Graft: a Pilot Study

Background: To our knowledge, no study evaluated the use of VCMX at multiple implant sites and compared its efficacy and safety to a SCTG with the same dimensions. Therefore, we propose in the present protocol to evaluate the efficacy of VMCX to increase the thickness and height of soft tissue when placed at the time of multiple implant placement, as compared to SCTG.

Material and Methods: This study will be conducted in the saint joseph university periodontology department on at least 5 to 10 patients. The studied sites are the edentulous posterior mandible in a split-mouth model. The test groups are the groups grafted with VCMX and the control groups are the groups grafted with SCTG.

Some studies have been reported to compare these two techniques. But the specificity of our study is soft tissue augmentation on multiple implant sites in a split-mouth design.


Eligibility Criteria:
Inclusion Criteria:

* Adults ;18 years old.
* Patients with adequate oral hygiene (FMPI\&amp;amp;lt;20% and FMBI\&amp;amp;lt;20%).
* Healed implant sites (tooth extraction at least 8 to 12 weeks before enrolment).
* Patients who need prosthetic rehabilitation of at least two implants in the left and right posterior mandibular area.
* Inadequate amount of soft tissue where the implants are planned to be placed: thin mucosal tissues covering the edentulous alveolar ridge.
* Compliant patients are willing to sign an informed consent.

Exclusion Criteria:

* Uncontrolled periodontal disease.
* Heavy smoker (\&amp;amp;gt;10 cigarettes per day).
* General contraindications for dental surgical treatment.
* Insufficient bone volume for implant placement requiring bone augmentation procedures.
* History of malignancy, radiotherapy, or chemotherapy for malignancy within the past 5 years.
* Pregnancy or breastfeeding.
* Previous and concurrent medication affecting bone and mucosal healing.
* Disease affecting bone and connective tissue metabolism.
* Immediate implant placement.
Dexmedetomidine and Nalbuphine as Analgesic Adjuvants to Bupivacaine in Superficial Cervical Block.

Anterior cervical discectomy and fusion (ACDF) nowadays is considered a common procedure.postoperative pain can hinder recovery and prolong hospital stay. The superficial cervical plexus block (SCPB) is a safe and simple technique that had been found to allow good pain relief in neck surgeries. The main drawback of SCPB was short duration, so adjuvants as dexmedetomidine and opioids has been used to increase analgesic duration and decrease the use of opioids.

The current study will compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to bupivacaine in SCPB in anterior cervical fusion surgeries.

The aim of the current study is to evaluate whether the addition of Dexmedetomidine to bupivacaine is comparable to the addition of nalbuphine in superficial cervical plexus block in patients undergoing ACDF.

thrity patients will be recruited. Patients will be divided randomly into either group A in which patients will receive SCPB consisting of bupivacaine 0.25%, dexmedetomidine 1 μg/kg (precedex 100mcg/ml), and adrenaline 1:200,000 in a total volume of 10ml normal saline, or Group B in which patients will receive SCPB consisting of bupivacaine 0.25% and 10 mg of Nalbuphine (nalufin 20mg/ml) and adrenaline 1:200,000 in a total volume of 10ml normal saline.

Eligibility Criteria:
Inclusion Criteria:

* Physical status ASA I and ASA ll.
* Both males and females
* Age 21- 60 years.
* Patients undergoing elective anterior cervical discectomy and fusion for 1 or 2 levels.

Exclusion Criteria:

* Patient refusal.
* Patients undergoing anterior cervical vertebrectomy and reconstruction.
* Patients with a history of allergy to local anesthetics or any used drugs in study.
* Infection at the site of the block.
* Patients with multiple cervical spine traumas.
* Patients having surgery for malignant tumors.
* Pre-existing peripheral neuropathies.
* Pregnant female.
* Patients with uncontrolled hypertension or cardiac problems as (heart block, sick sinus syndrome and ischemic heart disease).
* Patients with coagulopathy (INR\>1.5).
* Patients with failed block.
Hypofractionated Boost vs Conventionally Fractionated Boost for Localized High Risk Prostate Cancer

Randomized trial comparing 2 external beam radiotherapy fractionation schemes in patients with localized high risk prostate cancer. Primary endpoint is acute toxicity.

Patients enrolled onto this study will be randomized to one of the following treatment arms:

* Standard fractionation: Using 2 sequential IMRT plans, the pelvic lymph nodes and prostate will initially be treated to 46 Gy in 23 fractions, followed by a subsequent boost to the prostate to a total dose of 78 Gy.
* Hypofractionation: Using a one phase IMRT plan, the pelvic lymph nodes will be treated to a dose of 48 Gy in 25 fractions, while the prostate will be treated to a dose of 68 Gy in 25 fractions concomitantly (simulataneous integrated boost).

In addition, all patients receive 1.5- 3 years of androgen deprivation therapy.

Eligibility Criteria:
Inclusion Criteria:

* Written informed consent obtained.
* Histologically confirmed diagnosis of adenocarcinoma of the prostate.
* T1-2 N0 M0, Gleason Score \<= 7, PSA 20 - 100
* T1-2 N0 M0, Gleason Score 8 - 10, PSA \<= 100
* T3 N0 M0, any Gleason Score, PSA \<= 100

Exclusion Criteria:

* Patients with unilateral or bilateral hip replacement.
* Patients with active collagen vascular disease.
* Patients with active inflammatory bowel disease.
* Patients with previous radiotherapy to the pelvis.
* Patients with ataxia telangiectasia.
* Patients with nodal or distant metastases