cyrilzakka/clinical-trials huggingface dataset:
Study on the Role of FDG-PET in Patients With FL at Time of Relapse/Progression

The study is designed as a retrospective analysis of patients with relapsed/refractory FL identified by the hematological centers of Italy.

The study does not require any intervention on the patient, but it involves the simple collection of data that are already present in the medical record. Since this is a retrospective study, it will not require further analysis or diagnostic investigations than those already made.

Eligibility Criteria:
Inclusion Criteria:

* Patients with initial diagnosis of follicular lymphoma since 2001
* Histological confirmation of follicular lymphoma, grade I, II, III according to WHO 2008 classification, at the time of initial diagnosis
* Systemic first-line treatment with immuno-chemotherapy
* PET availability at the time of response after first-line treatment (optional)
* Clinical and radiological evidence of FL relapse or progression
* Histological confirmation of relapse (strongly recommended)
* PET availability of at the time of relapse/progression and images available for central assessment
* Availability of clinical, laboratory and therapeutic treatment data at the time of initial diagnosis and relapse/progression
* Follow up of at least 12 months after relapse/progression

Exclusion Criteria:

* None
Validation of Muscle Strength Testing for Pectoralis Major

This study wants to understand which direction of shoulder movement and what posture of shoulder are best for the procedure of muscle strength testing of the muscle pectoralis major(PM). We will use muscle activity signals (sEMG) and force measurement to analyze the contribution of two parts of PM in three different contraction direction with three different shoulder postures.


Eligibility Criteria:
Inclusion Criteria:

* Young male subjects which could expose the area of anterior chest to paste the sEMG electrodes

Exclusion Criteria:

* Injury and uncomforted one week before the test
Quality of Diet in Preschool Population

Childhood obesity is a problem of high prevalence and repercussions in adulthood. It is mostly due to inadequate life habits, modifiable through preventive strategies. The objective was to evaluate in the medium term the effectiveness of an intervention on adherence to the Mediterranean diet pattern in preschoolers.

Method: Community trial with two groups, in children between 3-5 years. The experimental group conducted a school garden and the usual contents on human body and health were taught in the control. Two schools were selected by cluster sampling, whose first unit of randomization were the educational areas followed by schools. The adaptation to the Mediterranean diet pattern was evaluated using the KIDMED questionnaire and weight, height, BMI and sociodemographic variables were controlled.


Eligibility Criteria:
Inclusion Criteria:

* Age between 3 and 5 years
* Oral comprehension of Spanish.

Exclusion Criteria:

* Existence of language barriers in parents defined as not understanding spoken or written Spanish.
* Treatment with glucocorticoids.
* Having chronic diseases that could interfere with somatometry.
Sleep Quality in Mechanically Ventilated Patients

Patients requiring mechanical ventilation in the ICU will undergo three consecutive nights of polysomnography to record sleep patterns while receiving three modes of mechanical ventilation; Proportional assist ventilation (PAV), Pressure support ventilation (PSV), Assist control ventilation (ACV), applied in random order. The purpose is to determine the effect of mode of mechanical ventilation on patient-ventilator asynchrony and sleep quality.


Eligibility Criteria:
Inclusion Criteria:

* Age 18-75
* received mechanical ventilation \>72 hours
* glasgow coma scale \>10
* acute physiology score \<13
* ready for partial ventilatory support: intact respiratory drive, PaO2/FiO2 ratio \>200 on positive end expiratory pressure (PEEP) less than or equal to 5 cmH2O, and PH of 7.35 to 7.45
* sedation: analgesia at dose not higher than 0.01 mg/kg/hr morphine equivalent x 48 hours, sedation at dose not higher than 0.01 mg/kg/hr lorazepam equivalent x 72 hours.
* anticipate ongoing need for partial ventilatory support for the following 72 hours

Exclusion Criteria:

* Successful completion of spontaneous breathing trial
* Neurological injury, encephalopathy or abnormal EEG
* History of central sleep apnea
* General anaesthesia within 72 hours from study entry
* Requiring haloperidol \>10 mg/24 hours
* hemodynamically unstable
* sepsis
Extension Study of Semapimod 60 mg IV x 3 Days

Study CNI-1493-CD06 is an open, single-arm extension studies to CD03 and CD05. CDAI is the only efficacy measure assessed in this study. The safety of multiple courses of semapimod is to be determined by the incidence of clinical and laboratory adverse events.


Eligibility Criteria:
Inclusion Criteria:

The study was open to patients who had satisfactorily completed either study CNI-1493-CD-03 or CNI-1493-CD-05. Initial entry criteria were:

1. Patients who satisfactorily completed either study CNI-1493-CD-03 or CD-05 were eligible for participation in this study. Satisfactory completion was defined as follows:

   1. The patient completed 5 treatment courses in the previous trial.
   2. The patient had responded to treatment, as defined by a decrease in CDAI of at least 70 points from original baseline (prior to treatment on study CD-02 or CD-04) at the last assessment for study CD-03 or CD-05, respectively. The decrease had to be attributable to semapimod treatment. Thus, patients whose response was attributable to other anti-Crohn's disease therapy are not to be included.
   3. The patient had no adverse event \>grade 2 felt to be probably or definitely related to study medication.
   4. The patient did not meet any discontinuation criterion in previous trial.
2. Patients had to sign informed consent specifically for this study, in addition to the consents for the previous studies, CNI-1493-CD-02 or CD-03, and CNI-1493-CD-04 or CD-05.
3. Patients could not take any other investigational therapies during the course of this study.
4. Men and women of childbearing potential had to be using a barrier method (diaphragm or condom) of contraception and continue doing so for at least 3 months after last study medication. It was strongly recommended that two forms be used.
5. Patients had to be able to adhere to the study visit schedule and/or protocol requirements.

Exclusion Criteria:

Could not have met any of the exclusion criteria for the CD02, 03, 04 or 05 studies.
Monitoring Skeletal Muscle Mass Using CBCT in Patients With H&N Cancer Undergoing Chemoradiotherapy

Chemoradiotherapy is the standard treatment for unresectable locally advanced head and neck cancer (HNC). However, malnutrition is present in 44-88% HNC patients during chemoradiotherapy, which leads to loss of skeletal muscle mass (SMM) and poor clinical outcomes. Timely assessment of SMM and early intervention of malnutrition are particularly important for HNC patients undergoing radiotherapy. However, body composition and skeletal muscle loss are not accurately reflected by the current assessment tools of malnutrition, which only measure body mass index and body weight loss.

Cone-beam CT (CBCT), a variation of traditional CT, is widely performed to ensure the appropriate position of the patients during radiotherapy. The previous study showed that measuring skeletal muscle areas and its changes using CBCT during radiotherapy is feasible. The hypothesis of this study is loss of SMM is associated with severe adverse effects in HNC patients during radiotherapy compared with body weight loss.

This is a prospective observational phase II study. Patients with locally advanced HNC scheduled to receive radical radiotherapy are prospectively enrolled in this study. CBCT and body weight are obtained before radiotherapy and once a week during radiotherapy. Severe adverse effects including grade 3-4 mucositis, dermatitis, haematological toxicity, interruption of radiotherapy, delayed chemotherapy, and unplanned admission are recorded during radiotherapy.

Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed HNC including Oral Cavity, Oropharyngeal, Nasopharynx, Hypopharyngeal, and Laryngeal Cancers
* Clinical stage II-IVa according to the American Joint Committee of Cancer (the seventh edition)
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Exclusion Criteria:

* Previous head and neck radiotherapy
* Previous cervical lymph node dissection
* Active infections
* Palliative treatment
Screening of Athletes

Athletes have to participate in screenings in order to reduce injuries. Up-to-now most screenings are purely clinically based. Literature, however, indicates the importance of knowledge on deviant movement patterns as possible risk factors for injuries. From this perspective, the current project aims to measure movement patterns, gait and running in young athletes to optimise training and prevent injuries.

2D- and 3d registration methods, force plate data and pressure plate data will be used to document the performance of the athletes.


Eligibility Criteria:
Inclusion Criteria:

1. Selected by the Flemish Athletics League
2. Level: B1, B2 en C
3. Age categories: 16-22 years
4. No injuries at lower back and lower extremities in the past 6 months
5. Signing informed consent

Exclusion Criteria:

1. Not selected by the Flemish Athletics League
2. Injuries at lower quadrant
Multimodality Treatment Including Curative Resection of Advanced NSCLC

This study retrospectively evaluates clinical parameters and outcome of patients with advanced stage non-small cell lung cancer treated with neoadjuvant therapy followed by curative-intent surgery at the Divison of Thoracic Surgery at the Medical University of Vienna

This study will be undertaken as a retrospective cohort study at Devision of Thoracic Surgery, Medical University of Vienna. All patients with non-small-cell lung cancer, who received an induction chemo- or chemoradiotherapy followed by surgery in a curative intention at the Devision of Thoracic Surgery, Medical University, will be included. The aim of this study is to evaluate peri- and postoperative clinical parameters and short- and long-term outcomes in patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients with advanced NSCLC and multimodality treatment including curative-intent resection

Exclusion Criteria:

* Patients with early stage NSCLC
* Patients with advanced NSCLC without multimodality treatment
* Patients without curative resection
GlowTest COVID-19 Antigen Home Test Kit Usability Study

The purpose of this study is to evaluate the usability of the GlowTest COVID-19 Antigen Home Test in Home Use.

The Arion Bio GlowTest COVID-19 Antigen Home Test is a lateral flow immunoassay intended for the qualitative detection of SARS-CoV-2 nucleocapsid protein antigens from individuals with or without symptoms or other epidemiological reasons to suspect a COVID-19 infection. The test is intended for non-prescription home use with self collected direct anterior nares swab samples from individuals ages 14 years and older or adult collected anterior nares swab samples from individuals aged 2 to 13.

Eligibility Criteria:
Inclusion Criteria:

1. An Institutional Review Board (IRB) approved informed consent/assent is signed and dated prior to any study-related activities.
2. Male and female Subjects 2 years of age and older.
3. Subject is willing to provide a self-collected nasal swab sample. (If under the age of 14, the sample will be collected by an adult.)
4. Subject agrees to complete all aspects of the study.

Exclusion Criteria:

1. Subject has a visual impairment that cannot be restored with glasses or contact lenses.
2. Subject has prior medical or laboratory training.
3. Subject uses home diagnostics, e.g., glucose meters, HIV tests.
4. Subject has prior experience with home COVID test kits
Salt Loading and Thiazide Intervention Study

The investigators of this study propose to examine the relationships between STK39 (Serine Threonine Kinase 39) genotypes and responses to salt loading and to thiazide diuretics, hydrochlorothiazide. The investigators hypothesize that STK39 genotypes will be associated with the outcome of both interventions and can contribute to personalized care for hypertension.

Although hypertension can be easily diagnosed and there are many medications available to treat hypertension, this condition is poorly managed in many patients and is a leading cause of morbidity and mortality worldwide. Because a newly identified hypertension susceptibility gene, STK39 (Serine Threonine Kinase 39), plays a central role in kidney sodium transport, the investigators propose a pharmacogenetics study to examine the relationships between STK39 genotypes and blood pressure responses to salt loading and to thiazide diuretics, hydrochlorothiazide. In addition, STK39 genotypes may also predict those hypertension patients more likely to develop thiazide-induced hyperglycemia. The investigators hypothesize that STK39 genotypes of those single nucleotide polymorphisms (SNPs) that are associated with baseline systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension status, will be associated with the outcome of both interventions. Therefore these SNPs can act as markers and contribute to personalized care for hypertension by identifying patients most likely to effectively control their blood pressure by adopting salt-reducing diet versus patients most likely to effectively and safely control their blood pressure by taking thiazide diuretics.

Eligibility Criteria:
Inclusion Criteria:

* Old Order Amish
* Age 18 to 65
* Have systolic blood pressure between 120 and 160 and diastolic blood pressure between 80 and 100

Exclusion Criteria:

* History of myocardial infarction, stroke, congestive heart failure, liver disease
* Known cause of secondary hypertension
* Diabetes or Fasting glucose \> 100 mg/dL
* Women who are pregnant, on oral contraceptives, or menstruating
* Used hydrochlorothiazide (HCTZ) in the last 8 weeks or known allergy to HCTZ
* Taking non-steroidal anti-inflammatory drugs
* Estimated glomerular filtration rate \< 80 mL/m
* Intention to alter dietary habit during the study
* Abuse of alcohol or drug
Cone Beam Computed Tomography For Appropriate Nostril Selection for Nasotracheal Intubation

Design: Nasotracheal intubation is a standard blind procedure associated with various complications. Selection of the appropriate nostril is crucial in preventing most of these complications. The investigators aimed to evaluate the contribution of CBCT findings in selecting the proper nostril for nasotracheal intubation.

Methods: This prospective observational study outlines the protocol for research conducted at the Selçuk University Faculty of Dentistry.

Scope of the Research: The study encompasses patients undergoing dental surgery under general anesthesia at the Selçuk University Faculty of Dentistry.

1. Participant Selection: ASA I-II patients will be included in the study. Patients with structural abnormalities in the maxillo-mandibular anatomy, limited mouth opening, comorbidities such as rheumatoid arthritis, and a history of epistaxis will be excluded from the study.
2. Anesthesia Method: General anesthesia induction will be performed with intravenous (IV) propofol, IV rocuronium bromide, and IV fentanyl. Transition to nasotracheal intubation will follow adequate mask ventilation, and the preferred nostril will be determined through a simple occlusion test.
3. Data Collection: Demographic data, accompanying illnesses, medications used, and various parameters related to nasotracheal intubation will be recorded. The anesthetist performing nasotracheal intubation will be blinded to CBCT data, and the evaluation of data will be conducted jointly by the anesthetist and Radiology specialist after data collection from all patients is complete.
4. Exclusion Criteria: Unsuccessful nasotracheal intubation, difficult mask, and/or difficult intubation.
5. Implementation and Evaluation: Anesthesia procedures and CBCT evaluations will be carried out by experienced specialists.
6. The objective of this study is to evaluate the use of preoperative measurements of the nasal cavity from CBCT images in selecting the appropriate nostril for nasotracheal intubation under general anesthesia. The statistical tests to be employed are the chi-squared test and independent samples t-test.

The goal of this prospective observational study is the contribution of CBCT findings in selecting the proper nostril for nasotracheal intubation. The main question it aim to answer is:

1. Can pre-operative evaluations of participiants' nasal cavity by using CBCT aid anesthetists for selecting the appropriate nostril for nasotracheal intubation? The participants will be informed both through a written consent form, and verbally that they would be participating in the observational study, and that apart from routine procedures, no additional interventions would be performed.

Eligibility Criteria:
Inclusion Criteria:

* ASA I-II patients

Exclusion Criteria:

* Clinical diagnosis of allergic rhinitis
* Patient with structural abnormalities in maxillo-mandibular anatomy,
* Patient with limited mouth opening
* Patient has previous history of epistaxis
Early Neurological Deterioration in Patients With Acute Ischemic Stroke

This study set out to explore the risk factors of early neurological deterioration (END) occurred in patients with acute ischemic stroke and to investigate the corresponding predictors.

END refers to the illness aggravation occurred in the early stage of stroke and often indicates a poor outcome. Some clinical scales may play an important role in its diagnoses and treatments. Across the reviewed studies, the risk factors of END, which included biochemical parameters, neuroimaging, ect. were explored incompletely and the effective predictors of END is unknown. We aimed to explore the risk factors of END and investigate the predictive value of certain scales.

Eligibility Criteria:
Inclusion Criteria:

* Subjects with acute ischemic stroke
* Subjects with detailed progress notes

Exclusion Criteria:

* Subjects with thrombolysis therapy
* Subjects with transient ischemia attach
* Subjects complicated with seriously underlying diseases
The HOP-STEP Intervention: Improving Maternal Health in Women With Lupus sIRB

While the HOP-STEP (Healthy Outcomes in Pregnancy with SLE Through Education of Providers) program has been demonstrated to be effective in improving provider confidence, increasing contraception documentation, and facilitating equitable pregnancy planning care in a single sub-specialty clinic here at Duke, the delivery of HOP-STEP may need to be changed to increase its fit with the local context at the University of Chicago Medical Center (UCMC) and subsequent locations. Thus, the investigators will now fit the intervention into a high-minority, high-poverty academic rheumatology center, and later pilot it through a randomized trial to identify and overcome existing barriers to equitable pregnancy prevention and planning at another institution (The University of Chicago Medical Center). The objective of this study is to prepare for a multi-center trial of the HOP-STEP intervention by fitting and then piloting its implementation and measuring its potential impact on maternal outcomes.

The study creates opportunities for SLE (systemic lupus erythematosus) patients seeking reproductive care by restructuring the rheumatology clinic environment. Specifically through:

Aim 1: Fit the implementation of the HOP-STEP Intervention to the local Rheumatology specialty clinic context with key stakeholder input.

Aim 2: Evaluation of a pilot trial of the HOP-STEP Intervention. At the completion of this study, the investigators will know how to equitably implement and study the HOP-STEP Intervention within an academic rheumatology setting that cares for a high-minority, high-poverty population of women with SLE.

Eligibility Criteria:
Provider Inclusion Criteria: Rheumatology providers who have seen at least 6 females 18-44 years old within the last year (at least 3 if provider has been at UCMC clinics for less than a year).

Exclusion Criteria: Rheumatology Fellows\*. Does not consent to join the study.
Is a THA Stem in Varus a Risk Factor of Long-term Mechanical Complication

The objective of this study is to compare the long-term survival as well as the functional and radiographic results of the rods in the alignment of the varus to the stems in the neutral alignment by comparing 2 groups of implanted Total Hip Arthroplasty. 1 group of stems implanted in varus position. 1 group of stems implanted in neutral position

ABSTRACT:

Introduction: Femoral stem positioning in the frontal plane has always been considered a fundamental criterion for implant survival and for functional and radiographic outcomes in total hip arthroplasty (THA). The impact of implanting cementless femoral stems in varus alignment on long-term mechanical complications remains poorly defined in the literature. The aim of our study is to compare long-term survivorship as well as functional and radiographic outcomes of stems in varus alignment to stems in neutral alignment.

Patients and Methods: This single center, multi-surgeon, retrospective case-control study will compare a group of 105 THA patients with varus stem alignment (VS) to a control group of 105 THA patients with neutral stem alignment (NS), operated in Brest center between January 2007 and December 2012. The primary outcome measure is implant survival. Secondary outcomes include functional outcomes: HHS, PMA, thigh pain, dislocation and hip ROM; and radiographic outcomes: radiolucency, Agora Roentgenography Assessment (ARA) score, osseointegration, heterotopic ossification, subsidence and stress shielding.

Eligibility Criteria:
Inclusion Criteria:

* PTH rod implanted in varus,
* Having X-rays and clinical data in their file
* Within a period of less than 6 months
* No opposition

Exclusion Criteria:

* PTH in a context of fracture of the femoral neck
* PTH 2nd intention
* Lost to sight
* Patients who died within 6 months
* Refusal to participate