cyrilzakka/clinical-trials huggingface dataset:
Mulligan's Mobilization and Proprioceptive Neuromuscular Facilitation Technique in Sacroiliac Joint Dysfunction

This study will aim to compare the effects of mulligan mobilization and PNF on pain and disability with patients of SIJ dysfunction and will be helpful for clinical physiotherapist to choose more effective treatment protocol for patients as there are fewer researches on comparison of these techniques.

The sacroiliac joint dysfunction syndrome (SIJDS) is an ongoing controversial issue and an important source of low back pain (LBP). It has been emphasized in many studies that the pathologies of sacroiliac joint (SIJ) are a source of pain in the lumbar spine and hip region. The prevalence of SIJDS in patients with chronic mechanical LBP is between 15 and 30% SIJD is a condition in which pain arises from the sacroiliac joint and is caused by the abnormal movement of ilium around the sacrum and abnormal function of the SIJ structures, like ligaments, muscles, capsules. The prevalence of SIJP has been stated to be up to 75% in LBP patients.

Physiotherapy techniques are used to correct SIJ mal-alignment manually by restoring the normal function and balance of lumbar and pelvic muscles and ligaments. Mulligan described the positional fault theory in which articular mal-alignment leads to altered kinematics and eventual dysfunction(2). Proprioceptive neuromuscular facilitation (PNF) is a form of flexibility exercises used to resolve muscle shortening and strain.

Eligibility Criteria:
Inclusion Criteria:

* Age 20 to 35 years

  * Both genders
  * Subjects with positive provocation test ( Faber's test\\Patricks test, Gaenslen test, distraction test, compression test, sacral thrust test)
  * Subjects with positive innominate test ( Stork Test\\Gillet Test)
  * Subjects who agree to fill the informed consent

Exclusion Criteria:

* Pregnant women

  * Presence of neurological signs
  * Patient with ankylosis spondylosis.
  * Patient has been diagnosed by disease other than SIJ dysfunction
  * Patients having any congenital posture problem or previous surgery
  * SLR less than 45 degree
  * Patient having any mental problem or reduced cognitive ability
Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China

This is a prospective, multi-center, non-randomized trial to study one-year outcomes of the Wingspan system for the treatment of Chinese patients with symptomatic atherosclerotic severe intracranial stenosis.

The study will enroll 200 Chinese patients with atherosclerotic intracranial stenosis of 70% to 99% that causes a recent ischemic neurologic event.

The Winspan stenting following undersized Gateway balloon angioplasty will be performed at experienced centers (at least 10 cases' experiences of using the Wingspan system to treat the patients with intracranial stenosis for each center).

The primary endpoint of the study, independently evaluated by neurologists, is any stroke or death within 30 days, plus ischemic stroke in the stented artery territory between 31 day and 1 year.

Eligibility Criteria:
Inclusion Criteria:

* An angiographically verified ≥ 70% stenosis of a major intracranial artery that causes TIA or minor stroke (NIH Stroke Scale score \<9) within 90 days;
* the lesion length \<15 mm and normal arterial diameter adjacent to it between 2.0 mm and 4.5 mm;
* patients having at least one atherosclerotic risk factor (arterial hypertension, diabetes mellitus, hyperlipidemia, hyperhomocysteinemia and cigarette smoking).

Exclusion Criteria:

* Non-atherosclerotic stenosis;
* intracranial hemorrhage in the territory of the stenotic artery within 6 weeks; potential source of cardiac embolism;
* concurrent intracranial tumor, aneurysm and cerebral arteriovenous malformation;
* tandem \>50% stenosis of extracranial carotid or vertebral artery; known contraindication to heparin, aspirin, clopidogrel, anesthesia and contrast media; hemoglobin \<10 g/dl, platelet count \<100,000;
* international normalized ratio \>1.5 (irreversible) and uncorrectable bleeding diathesis; and life expectancy \<1 years because of other medical conditions.
Effects of Mobile Medicine on Cancer Patients

With the existing medical system and insufficient medical resources in China, we developed a mini program. a pain management mini app can be useful and appreciated by patients and health care professionals, making it a good choice for the management of cancer pain in our country . our study want to develop and test the mini program for pain management among Chinese cancer patients in or discharged from hospital treatment.

Healthcare interventions delivered via personal mobile device have been shown to be acceptable to users, who have identified benefits such as convenience, access to personalized information, greater awareness of own health. Integrating mini program into the cancer pain care may be an effective strategy to improve cancer pain patients self-management.

To design, construct, and test the mini program in patients managing cancer pain, evaluate the total remission rate of pain and the improvement in medicine compliance to improve pain management for cancer pain patients, and assess patient acceptance of the mini program.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 years or older;
* Be able to read Chinese and use a mobile phone;
* Histologically or cytologically confirmed solid tumor;
* Diagnosed chronic cancer pain
* Could understand the study process and evaluation, agreed to participate in the trial, and signed the informed consent form.

Exclusion Criteria:

* Illiterate person;
* Incompetence;
* Inability to complete the pain assessment;
* Participation in any other therapies or other study protocols that may have an impact on pain intensity, which were the main outcomes of this study.
Dexmedetomidine as an Intrathecal Adjuvant to Hyperbaric Bupivacaine for Postoperative Analgesia in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction Surgeries

This study aimed to evaluate the effect of adding low doses of dexmedetomidine to hyperbaric bupivacaine during spinal anesthesia on post operative analgesia characteristics in Arthroscopic Anterior Cruciate Ligament Reconstruction Surgeries

The anterior cruciate ligament (ACL) is injured frequently during sports participation. Arthroscopic evaluation of patients with acute traumatic hemarthrosis of the knee has repeatedly demonstrated a 60% to 70% incidence of ACL injury.

Postoperative pain should be effectively treated because it represents an important component of postoperative recovery. Effective treatment serves to blunt autonomic, somatic, and endocrine reflexes with a resultant potential decrease in perioperative morbidity.

Dexmedetomidine is a highly selective α2-adrenergic agonist that has been used for premedication and as an adjunct to general anesthesia. It reduces opioid and inhalational anesthetics requirements.

Eligibility Criteria:
Inclusion Criteria:

* Aged from 21 to 50 years.
* Both genders.
* American society of anesthesiologists (ASA) physical status I and II.
* Patients scheduled for arthroscopic anterior cruciate ligament reconstruction surgeries under spinal anesthesia.

Exclusion Criteria:

* Patient refusal.
* Body Mass Index (BMI) more than 40 kg/m2.
* Patients who were taking analgesics for chronic pain on opioid therapy or have a history of drug abuse.
* Uncooperative patient.
* Patients with coagulation disorders.
* History of local anesthetics allergy.
* Infection at the needle puncture site.
* Patients with significant respiratory, cardiac, renal or hepatic disorders
Effects of Interpersonal Psychotherapy on Depression During and After Pregnancy

This study will evaluate the impact of interpersonal psychotherapy on the course of depression during and after pregnancy, as well as its effect on infant birth outcomes.

Depression is a serious illness that affects a person's body, mood, and thoughts. Researchers believe that it is one of the most common complications during and after pregnancy. The following symptoms may be signs of depression during pregnancy: 2 or more weeks of depressed mood; decreased interest or pleasure in activities; change in appetite or sleep patterns; fatigue or decreased energy; difficulty concentrating; excessive feelings of guilt or worthlessness; thoughts of suicide; and extreme restlessness or irritability. Depression is difficult to diagnose during pregnancy because its symptoms are sometimes confused with those of pregnancy. If left untreated, depression during pregnancy may affect not only the mother, but also the baby. Specifically, the hormone changes brought on by depression may contribute to premature and low-birth-weight infants. Interpersonal psychotherapy (IPT) is a short-term talking therapy that has been proven to be effective in treating depression. This study will evaluate the impact of interpersonal psychotherapy on the course of depression during and after pregnancy, as well as its effect on infant birth outcomes.

This study is associated with a larger parent study. Participants in this open-label study may be recruited directly for this study or through the parent study. All participants will receive 16 sessions of IPT. Sessions will last approximately 50 minutes and will focus on achieving depression symptom remission by improving interpersonal functioning. The majority of IPT sessions will be held prior to delivery; up to four sessions may be held postpartum. No medication will be provided in this study, but women who are currently taking selective serotonin uptake inhibitors (SSRIs) at the time of study entry may continue taking their medication. Participants whose symptoms do not improve with IPT will be referred to their non-study physician for further evaluation, and may begin taking SSRI medication upon physician recommendation. The effects of both IPT and medication therapy will be considered when assessing outcomes. Study visits will occur at 28, 32, and 36 weeks gestation, as well as Weeks 1, 2, and 6, and Month 6 postpartum. Measurements will include cortisol levels, which will be obtained using a saliva sample, as well as depression symptom severity, which will be assessed at each IPT session. Blood samples will be taken as part of the parent study.

Eligibility Criteria:
Inclusion Criteria:

* No more than 28 weeks pregnant at the time of study entry
* History of depression or anxiety
* Current symptoms of distress
* Score of 9 or greater on the Edinburgh Postnatal Depression Scale (EPDS)
* English-speaking

Exclusion Criteria:

* Plans to move away from the area prior to giving birth
* Current use of steroids for medical conditions
The Effect Of Reiki And Massage With Sage Oil On Primary Dysmenorrhea

This study was a randomized controlled trial. It included young girls with primary dysmenorrhea in a district located in the south of Turkey and was conducted between March 01, 2021 and June 30, 2021. The sample size of this research was decided by performing a power analysis in the power statistical program. Considering the parameters of the groups, the effect size was calculated to be 0.5003604. Since α was found to be 0.05 and power (1 - β) was 0.95, a total number of 66 participants were distributed into three equal groups (sage oil massage: 22, Reiki: 22, control: 22). Considering the possibility of case losses, 30 participants were included in each group; finally, a total of 90 people were included in the study. For data collection, a questionnaire regarding sociodemographic characteristics and the visual analog scale (VAS) were used. Reiki and massage with sage oil were applied for 30 minutes, and no application was performed on the control group.


Eligibility Criteria:
Inclusion Criteria:

Being female Not married

Exclusion Criteria:

Psychiatric problem Communication barrier Those who refuse to work
Evaluation of Dysphagia by 6-chnnel Surface Electromyography

The natural process of aging affects a few very specific timing parameters such as swallow reaction time and hyoid one movement velocity.

Many swallow timing and bolus transit parameters appear to be unaffected by aging. We want to know the changes of kinematic variables according to the aging process.

First hypothesis: There are probably be a protection mechanism that blocks functional loss progressing to kinematic abnormality. Muscle activation sequence change (i.e duration or amplitude) of the oropharyngeal muscles play an important role.

Second hypothesis: Age-related differences in muscle activation patterns will also appear differently depending on the characteristics of swallowed food.

Inclusion criteria

Inclusion criteria of healthy older adults : Age \> 60, without dysphagia, comorbidity

Inclusion criteria of young control group

: Age \< 60, without dysphagia, comorbidity

No prior history of swallowing difficulty or history of central nervous system disease, and none were taking medication that are known to affect swallowing.

Surface EMG was performed at bilateral suprahyoid, thyrohyoid, sternothyroid and pharyngeal constrictors. The latency of activation and termination was checked.

Eligibility Criteria:
Inclusion Criteria of old group

* Age \> 60, without dysphagia, comorbidity

Inclusion Criteria of young control group

* Age \< 60, without dysphagia, comorbidity
Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training

The purpose of the study is to tests the hypothesis, that N-acetylcysteine (a thiol-antioxidant)improves the exercise training effect on cancer patients that experience weight loss (cachexia) as assessed by muscle mass and function as well as histomorphology.


Eligibility Criteria:
Inclusion Criteria:

* gastrointestinal or bronchial cancer
* weight loss of 10% within 6 months
* sufficient mobility

Exclusion Criteria:

* severe pain, steroid therapy, severe internal, muscular, neurological, psychiatric disease, N-acetylcysteine allergy
Bioavailability of BI 1356 BS and Metformin After Co-administration Compared to the Bioavailability of BI 1356 BS Alone and Metformin Alone in Healthy Male Volunteers

Investigate the bioavailability of BI 1356 BS and of metformin after concomitant multiple oral administration of 10 mg BI 1356 BS tablets and 3 x 850 mg metformin in comparison to BI 1356 BS and metformin given alone


Eligibility Criteria:
Inclusion Criteria:

* Healthy males according to the following criteria, based upon a complete medical history, including the physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead electrocardiogram (ECG), clinical laboratory tests

  * No finding deviating from normal and of clinical relevance
  * No evidence of a clinically relevant concomitant disease
* Age ≥ 21 and Age ≤ 50 years
* BMI (Body Mass Index) ≥ 18.5 and ≤ 29.9 kg/m2
* Ability to give signed and dated written informed consent prior to admission to the study in accordance with good clinical practice (GCP) and the local legislation

Exclusion Criteria:

* Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders
* Surgery of the gastrointestinal tract (except appendectomy)
* Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders
* History of relevant orthostatic hypotension, fainting spells or blackouts
* Chronic or relevant acute infections
* History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial by the investigator
* Intake of drugs with a long half-life (\>24 hours) within one month or less than 10 half-lives of the respective drug prior to administration or during the conduct of this trial (review with clinical monitor if there is a question)
* Use of drugs which might reasonably influence the results of the trial (based on knowledge at the time of protocol preparation) within 10 days prior to administration or during the conduct of this trial
* Participation in another trial with an investigational drug within two months prior to administration or during the conduct of this trial
* Smoker (more than 10 cigarettes or 3 cigars or 3 pipes per day)
* Inability to refrain from smoking during the conduct of this trial
* Alcohol abuse (more than 60 g/day)
* Drug abuse
* Blood donation (more than 100 mL within four weeks prior to administration or during the conduct of this trial)
* Excessive physical activities (within one week prior to administration or during the conduct of this trial)
* Any laboratory value outside the normal reference range that is of clinical relevance
* Inability to comply with the dietary regimen of the study center
* No adequate contraception (condom use plus another form of contraception e.g., spermicide, oral contraceptive taken by female partner, sterilization) during the whole study period from the time of the first intake of study drug until one month after the last intake of drug
The Prevalence of Oral Habits in a Group of Primary School Children in Cairo Governorate

This study is designed to determine the prevalence of oral habits among primary Egyptian school children in Cairo Governorate, Egypt.

This aim of this study is to determine the prevalence of oral habits among primary Egyptian school children in Cairo Governorate, Egypt.

PICO:

P: Egyptian primary school children of 7 - 10 years old

O: Prevalence of oral habits

Primary Outcome: Prevalence of Oral Habit; Device of Measurement: Questionnaire; Unit of Measurement: Binary.

Eligibility Criteria:
Inclusion Criteria:

* Cooperative children of 7-10 years old
* Children with no intellectual problems

Exclusion Criteria:

* Children with orthodontic appliances
* Medically compromised children
* Children of families who refuse to participate in the study
Age Bias on Biopsychosocial Factors in Persons With Non-specific Low Back Pain.

Low back pain is a debilitating condition experienced by people of all age groups. This study will be completed in two stages in which back pain assessment tools will be first translated to Urdu language and later on age-related bias on biopsychosocial factors will be assessed using various biopsychosocial tools over a period of six months.

Low back pain (LBP) is an extremely common symptom experienced by people of all ages. The current incidence, prevalence and disability-adjusted life years (DALYs) account for 245.9 million cases/year (15th worldwide cause; 32.4% cases associated with leg pain), 577.0 million cases (15th worldwide cause) and 64.9 million DALYs (6th worldwide cause), respectively. In recent decades, the biopsychosocial model has been applied as a framework for understanding the complexity of low back pain disability in preference to a purely biomedical approach. Considering the large population of patients with LBP and limited medical resources, the development of brief and efficient prognostic clinical tools for use in routine practice is particularly significant. Recent data from epidemiological studies suggest that LBP could affect the physical function of young and older individuals differently. The age-related differ¬ences in the prevalence of some low back pathologies may explain the differential treatment outcomes. The aim of the study is to explore the age bias on biopsychosocial factors in persons with non-specific low back pain.

Eligibility Criteria:
Inclusion Criteria:

1. Both male \& Female patients
2. Age group 20-60 Years
3. Diagnosed with nonspecific low back pain for more than 3 months (i.e., pain localized below the costal margin and above the inferior gluteal folds with or without referred leg pain of a nociceptive mechanical nature, not attributable to a recognizable, known specific spinal pathology, for a period of at least twelve weeks)

Exclusion Criteria:

Any serious conditions like neurological conditions which would not allow the patient to fill the questionnaire independently, any infection, tumor, spinal surgery, cognitive impairments, or any other rheumatologic disease would be excluded.
Acupuncture to Enhance for Pulmonary Rehab

The investigator is investigating if acupuncture may improve pulmonary function, exercise tolerance, stress and modulate the inflammatory effects of chronic obstructive pulmonary disease (COPD). The investigator would like to measure the effect of the combination of acupuncture with standard pulmonary rehab in patients with COPD.

Participation in this study may last 3 months. The experimental intervention is electro-acupuncture. Electro-acupuncture is similar to Transcutaneous Electrical Nerve Stimulation (TENS) where a very small current of electricity is applied, in this case to specific acupuncture points. The intervention will be applied by a trained physician-acupuncturist. The treatment itself would be applied for 20 minutes prior to regularly scheduled pulmonary rehab session. All participants will receive electro-acupuncture for the duration of the study. Because the investigators are interested in the effect of dose, participants will be randomized to 4, 8 or 12 weeks of "active pulmonary" acupuncture versus "control" acupuncture. One third of the participants will be asked to undergo the intervention for 4 weeks, one third will be asked to undergo the intervention for 8 weeks and one third will be asked to undergo the intervention for 12 weeks. Intervention acupuncture needles will be placed on what are thought to be active points for helping lung function, control acupuncture needles will be placed in neutral locations. Participants will not be told which weeks they are receiving the active acupuncture versus the control. Information relating to pulmonary and physical function, standard blood markers of inflammation, and survey responses at the beginning, during and after the intervention will be collected. During the experimental period participants will be asked to fill out surveys on quality of life, pulmonary function and physical function.

Eligibility Criteria:
Inclusion Criteria:

* Patients must be 18 years of age or older
* Qualify to participate in the pulmonary rehab program at DHMC

Exclusion Criteria:

* Severe cognitive impairment
* Active pulmonary exacerbation
* Unstable cardiopulmonary disease