Study to Learn More About the Effect of a New Drug Called BAY2327949 on the Blood Flow Through Kidneys in Adult Participants With Moderate Chronic Kidney Disease

Researchers in this study want to learn more about the effect of a new drug called BAY2327949 on the blood flow through kidneys in adult participants with moderate long lasting kidney disease. It is thought that, in long lasting kidney disease, blood flow through the kidney tissue is changed, and that some parts of the kidney may receive less oxygen and nutrients because of this. BAY2327949 is a new drug under development with a goal to modify how much blood is flowing through kidneys. It works by binding to and blocking proteins that can regulate blood flow through the kidneys.

Participants in this study will receive 3 tablets of BAY2327949 once and 3 tablets of Placebo once (a placebo looks like a drug but does not have any medicine in it). Both BAY2327949 and Placebo will be taken orally. And after taking each of them, participants will undergo a Magnetic Resonance Imaging (MRI) scanning for 60 to 90 minutes to assess the blood flow to kidneys. MRI is an examination of parts of the body (in this case the kidney) which provides images of these regions. Blood samples will be collected from the participants to check the general health and look at how the study drug is working in the body and how the body affects the study drug. Participants will visit the hospital or clinic about 4 times in total, and the observation for each participant will not more than 56 days.


Eligibility Criteria:
Inclusion Criteria:

* Participant must be 18 to 75 years of age inclusive, at the time of signing the informed consent
* Clinical diagnosis of CKD for at least 6 months, with eGFR ≥30 mL/min/1.73 m2 but \<60 mL/min/1.73 m2 (eGFR will be estimated at study site from serum creatinine using the Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] formula)
* Copeptin level of ≥10 pmol/L at the screening visit
* Men or confirmed postmenopausal women (documented by medical report verification and defined as exhibiting spontaneous amenorrhea for at least 12 months before screening or as exhibiting spontaneous amenorrhea for 6 months before screening with documented serum follicle-stimulating hormone \[FSH\] levels \>40 mIU/mL) or women without childbearing potential based on surgical treatment 6 weeks before screening such as bilateral tubal ligation, bilateral oophorectomy or hysterectomy (documented by medical report verification).

Sexually active men, who have not been surgically sterilized, must agree to use 2 reliable and acceptable methods of contraception simultaneously (whereby one method has to be applied in the man and one method in the female partner), and not to act as sperm donor. This applies for the time period between signing of the informed consent form (ICF) and 12 weeks after the last administration of study drug.

Acceptable methods of contraception include, but are not limited to, (i) condoms (male or female) with or without a spermicidal agent; (ii) diaphragm or cervical cap with spermicide; (iii) intra-uterine device; (iv) hormone-based contraception.

* Participants must be able to meet the requirements of the MRI scan (e.g. physically able to fit into the scanner)
* If patient is taking loop diuretics, must be able to discontinue loop diuretics in the morning of Visit 2 and Visit 3.

Exclusion Criteria:

* Known acute kidney diseases (incl. kidney stones) or renal conditions that in the opinion of the investigator are expected to significantly change in intensity over the study period
* Clinical diagnoses of heart failure and persistent symptoms (New York Heart Association class III - IV)
* Systolic blood pressure \>160 mmHg, or diastolic blood pressure ≥100 mmHg
* Stroke, transient ischemic cerebral attack, acute coronary syndrome, hospitalization for worsening heart failure or unplanned/emergency hospitalization in the last 3 months prior to randomization
* Renal allograft in place
* Hepatic insufficiency classified as Child-Pugh B or C, or active hepatitis B or C at Visit 1.
* Active malignancy aside from treated squamous cell or basal cell carcinoma of the skin
* Dialysis for acute renal failure within the previous 6 months prior to randomization
* Indication for immunosuppressants, receiving cytotoxic therapy, immunosuppressive therapy, or other immunotherapy within 6 months prior to randomization
* Participant is taking concomitant medication that is:
* - A moderate or strong inhibitor of cytochrome P450 (CYP)3A
* - A moderate or strong inducer of CYP3A
* - A moderate or strong inhibitor of P-glycoprotein transport
* Any medication, surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of the study intervention
* Previous (i.e. within 3 months prior to randomization) or concomitant participation in another clinical study with the study intervention
* Body mass index (BMI) \>35 kg/m²
* Body weight exceeding 120 kg
* Glycosylated hemoglobin (HbA1c) \>11% at Visit 1
* History or suggestive of alcohol or substance abuse
* Planned change in dose or schedule of concomitant medication within 4 weeks prior to Visit 1, or planned change during the time course of this study
* Criteria which in the opinion of the investigator preclude participation for scientific reasons, for reasons of compliance, or for reasons of the participant's safety
* Any other conditions which, in the opinion of the investigator or sponsor, would make the participant unsuitable for inclusion or could interfere with the participant's participation in or completion of the study
* Close affiliation of the participant with the investigational site, e.g. a close relative of the investigator, dependent person (e.g. employee or student of the investigational site)
* Participant is in custody by order of an authority or court of law