cyrilzakka/clinical-trials huggingface dataset:
Exercise Application in the Treatment of Patients With Subacromial Pain Syndrome

This study evaluate the effectiveness of adding neuromuscular exercises with tactile, visual and auditory feedback to a scapula-focused treatment, both emphasizing the periscapular muscles on improvement of disability in patients with subacromial pain syndrome compared to patients receiving only strengthening exercise protocol.

Evidence of the effectiveness conservative treatments in shoulder impingement are in favor the application of specific exercises for scapulothoracic muscles and rotator cuff on pain reduction and improvement of upper limb function, supervised or performed at home, and these same exercises associated with other therapies promote a greater reduction in pain and improvement in disability.

Currently, the evidence of better methodological quality present in the literature13 points out that the performance of motor control exercises focused on the scapula associated with mobilization and stretching generate pain improvement and clinically relevant improvement of the function. The few studies in this area have great methodological diversity with significant limitations. The hypothesis is that patients with subacromial pain syndrome who will receive traditional exercise protocol with the addition of neuromuscular training will show less functional disability, a greater reduction in pain intensity, increase muscle strength and range of motion when compared to the patient group that will receive only the protocol without neuromuscular training, immediately after the intervention, four and eight weeks and four months after randomization and that these benefits are clinically relevant.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of subacromial pain syndrome with confirmed positivity in at least three of the five specific orthopedic impact tests: Neer test, Hawkins- Kennedy test, painful arc, external rotation resistance and empty can. Present history of pain in the shoulder lasting more than a week located in the proximal area of the shoulder

Exclusion Criteria:

* Subjects with a history of trauma or shoulder surgery, total rupture of the rotator cuff tendon and biceps, physically active involving the upper limbs or considered active accordance with the short version International Physical Activity Questionnaire (IPAQ). Subjects who have neurological diseases, referred pain in arms (indicative of involvement in the cervical or thoracic region), systemic disease involving the joints such as rheumatoid arthritis or fibromyalgia, the presence of disorders in the wrist such as carpal tunnel syndrome, and have done physical therapy in the shoulder the last six months.
Defense and Veterans Center for Integrative Pain Management (DVCIPM) Pain Registry Biobank

This Pain Registry Biobank is a prospective cohort design study whereby data (PASTOR survey, blood and saliva specimens, clinical data) is collected from participants in a longitudinal fashion with continual enrollment.

The Defense and Veterans Center for Integrative Pain Management (DVCIPM) established a clinical data registry and tissue biobank (pain registry/biobank) for the advancement of pain-related research. This Pain Registry Biobank will address the complexity of pain by utilizing the Pain Assessment Screening Tool \& Outcomes Registry (PASTOR), a thorough biopsychosocial assessment that extends beyond a single-item pain rating scale. PASTOR is an assessment battery that includes several Patient Reported Outcomes Measurement Information System (PROMIS) scales developed by the National Institutes of Health (NIH) and other important scales that span physical, psychological, social, and behavioral aspects of pain and pain-related treatments. As a uniform assessment system, PASTOR also mitigates a significant challenge in pain-related research, the lack of standardized, cross-study outcomes. Additionally, the richness of PASTOR data matched with biological samples allows future researchers to address significant research gaps and enhance health care for service members, veterans, and civilians.

Eligibility Criteria:
Inclusion Criteria:

* Eligibile for care within the Military Healthcare System
* Able and willing to provide written consent

Exclusion Criteria:

* Cannot understand English
Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing Spondylitis

This is the first study of oral tofacitinib in adults with active ankylosing spondylitis. It is designed to obtain information on the efficacy and safety of 3 different doses of tofacitinib.


Eligibility Criteria:
Inclusion Criteria:

* Documented diagnosis of Ankylosing Spondylitis
* Has active disease despite concurrent nonsteroidal anti-inflammatory drugs (NSAIDs) treatment or is intolerant to NSAIDs

Exclusion Criteria:

* Pregnant or lactating females
* Currently receiving or previous use of a Tumor Necrosis Factor (TNF) inhibitor or any biological agent
Vestibular Stimulation and Neurodevelopmental Technique on Hypotonic Cerebral Palsy While Controlling the Gender

there is no such article found who specifies the effects of sensory integration therapies like vestibular stimulation technique or developmental milestone while controlling the gender of children with cerebral palsy. So, there is a need to do more research work on this in future to find out best treatment approach for children with cerebral palsy of their respective gender. That is why this study will focus on the results of vestibular stimulation and neurodevelopmental technique while controlling the Gender distribution of both intervention groups to find out the effects of these interventions that wither, they have some influence on the participants or not.

Bobath concept of neurodevelopment in children with cerebral palsy, is a problem-solving approach to the assessment and treatment of individuals with disturbances of tone, movement, and function due to a lesion of CNS, the goal of treatment is to optimize function by improving postural control and selective movement through facilitation. But also, no study found which specifically focuses the improvements on boys and girl's ratio or their gender-based improvements of tone or developmental milestones.

Different swings such as Infant Swing, frog swing, platform swing will be included as mode of Vestibular stimulation treatment. On the other side, Stimulation of vestibular system improved child's postural control and motor function in many studies.

Eligibility Criteria:
Inclusion Criteria:

* Hypotonic CP
* GMFM-88 ranges: With true score of zero (0) = does not initiates i.e., head control absent at age of 6 months
* Tone: 6 months infants total scoring ≤ 54 and 8 month or more total scoring ≤ 68 on Infant Neurological international Battery Scoring Sheet will be included.

Exclusion Criteria:

* Children with other Abnormalities and pathologies like Down syndrome, Joubert Syndrome

  * Children Undergone any kind of surgery like reconstruction surgeries for congenital defects of eyes, head, neck or all four limbs of the body
  * Children with other type of Cerebral Palsy (CP) like Spastic (Hypertonic), Choreoathetoid, Dystonic, Ataxia, Athetoid and mixed CP
  * Children with any other neurological deficits, Mentally Challenged.
The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery

Melatonin has sedative, hypnotic and analgesic properties that make it a good premedication agent before anesthesia and surgery.

In this study the investigators intend to randomise 60 patients undergoing bariatric surgery into two groups. The participants will receive either melatonin or placebo on the evening prior to the surgery, and the same agent two hours before the surgery.

The patients recovery from the surgery and anesthesia will be assessed using the Q0R15 questionnaire. The patients will be asked to take the questionnaire once in the pre-operative clinic, again after the second melatonin or placebo pill before entering the operating room, and once more on the first post-operative day.

Melatonin has sedative, hypnotic, analgesic, antiinflammatory, and chronobiologic properties that make it a good premedication agent before anesthesia and surgery. Patients undergoing surgery in our establishment usually receive benzodiazepines as premedicants to reduce anxiety before the surgery. For bariatric patients benzodiazepines are usually avoided due to side effects which could be deleterious in obese patients.

In this study the investigators intend to randomise 60 patients undergoing bariatric surgery into two groups. The participants will receive either melatonin or placebo on the evening prior to the surgery, and the same agent two hours before the surgery.

The patients recovery from the surgery and anesthesia will be assessed using the Q0R15 questionnaire. The patients will be asked to take the questionnaire once in the pre-operative clinic, again after the second melatonin or placebo pill before entering the operating room, and once more on the first post-operative day.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing bariatric surgery

Exclusion Criteria:

* Known allergy to melatonin
Laparoscopic Tactile Imaging in Urogynecologic Surgery

During laparoscopic surgery, video camera becomes a surgeon's eyes since the surgeon uses image from the video camera positioned inside the patient's body to perform the procedure. The greatest limitation is the impairment or complete lack of tactile sensation normally used to assist in surgical dissection and decision making. The Investigator proposes to develop a tactile sensing system, Laparoscopic Tactile Imager (LTI), to be used in urogynecological laparoscopic surgery for tactile imaging and tissue characterization (elasticity, structure, boundaries, blood vessel detection) which will be imposed on the video image at area of interest in real time.

For this study, the investigator identified the sacrocolpopexy as the target procedure for the evaluation of LTI. In the cases of sacrocolpopexy, often performed in conjunction with a hysterectomy, one of the most frustrating elements is the lack of tactile feedback at the level of the sacral promontory. The surgeon needs to open up the peritoneum and dissect the underlying tissue to expose the sacral bony structures and ligament without injury to the surrounding bowel, ureter or vascular structures. Sometimes, the sacral promontory is covered with a fat pad which makes it difficult to visualize the promontory and the "safe" space below the aorta and between the iliac arteries/veins is difficult to discern. A difference that is very easy to appreciate with an open procedure where one can easily palpate through the fatty tissues. That step is very critical for the repair and has the greatest potential for catastrophic error without tactile sensation. Because of the reproducibility of the surgical technique and target anatomy for this portion of the procedure, it was thought the sacral promontory dissection to identify and clear the anterior longitudinal ligament would be appropriate surgical procedure to evaluate the use of LTI.

Eligibility Criteria:
Inclusion Criteria:

1. Stage 2 or greater pelvic organ prolapse;
2. Scheduled pelvic floor surgery.

Exclusion Criteria:

1. Active cancer of the colon, rectum wall, cervix, vaginal, uterus or bladder;
2. Ongoing or prior radiation therapy for abdominal or pelvic cancer;
3. Recent (less than four months) pelvic surgery;
4. Surgically absent rectum or bladder;
5. Significant circulatory or cardiac conditions that could cause excessive risk from the examination as determined by attending physician;
6. Severe abdominal or pelvic adhesions preventing access to pertinent anatomy;
7. Known or suspected bleeding disorder.
A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram

Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction. Endothelial dysfunction is also reported to be linked to obstructive sleep apnea. While chest pain can be one of potential presenting symptoms of obstructive sleep apnea, the investigators hypothesize that obstructive sleep apnea is common in subjects with cardiac syndrome X.


Eligibility Criteria:
Inclusion Criteria:

* Age ≧18 years, \< 70 years
* Symptom of chest pain occurring at least once in the preceding year
* Positive exercise treadmill test
* Negative coronary angiogram
* Mentally fit to give informed consent

Exclusion Criteria:

* Mentally incapacitated persons
* Congestive heart failure
* Other potential causes of orthopnea (severe chronic obstructive pulmonary disease, persistent asthma)
Efficacy and Safety of Bovine Intestinal Alkaline Phosphatase (bIAP) During Heart Surgery

This multi-centre prospective, randomised, double-blind, placebo-controlled study is designed to evaluate the efficacy and safety of bovine intestinal alkaline phosphatase (bIAP) in reducing the pro-inflammatory post-surgical responses and thereby preserving organ functions in patients undergoing invasive cardiac surgery: combined aortic valve replacement and coronary artery bypass grafting.


Eligibility Criteria:
Inclusion Criteria:

* Male or non-pregnant, non-lactating female patients of any race in the ages of \>18 years.
* Patients scheduled for combined aortic valve replacement and CABG surgery.
* Patients who have given written informed consent prior to participation in the trial and who undertake to comply with the protocol.

Exclusion Criteria:

* Patients who are unwilling or unable to be fully evaluated for follow-up.
* Patients who have base AP levels at \> 125 IU/L, or levels \< 30 IU/L (ammediol, DEA (diethanolamine) units)
* Patients who show pre-operative infections or who are suspected of endocarditis or systemic infection.
* Patients who refuse to accept medically-indicated blood products.
* Patients who have evidence of significant hepatic disease, including history of clinical signs or laboratory values of total bilirubin \> 34.2 µmol/L (\> 2.0 mg/dL), ALT (\>120) or AST (\>135) corresponding to \> 3X upper limit of normal.
* Patients who received investigational drugs in the 30 days prior to study drug administration, or are currently participating in a study during which the administration of investigational drugs within one month is anticipated.
* Patients who require pre-operative ventilatory support.
* Patients who have renal insufficiency (history of creatinine \>177mol/L or \>2.0 mg/dL) or chronic renal failure requiring dialysis.
* Patients who are planned to receive leukocyte-depletion filtration as part of the bypass circuitry.
* Patients with severe neurological deficits.
* Patients who have a recent history of drug or alcohol abuse.
* Patients with a diagnosis of idiopathic thrombocytopenia.
* Patients with a history of cancer who have received chemotherapy or radiation therapy within the past 3 months. Patients receiving only adjuvant hormonal therapy are not excluded.
* Patients who are scheduled to receive "stress doses" of glucocorticoids (i.e., doses \>2 mg/kg/day of methylprednisolone or equivalent) prior to, during or following surgery.
* Patients who are vegetarians or veganists or those patients that may be expected not to be tolerant for bovine proteins.
* Patients who are, in the opinion of the investigator, unsuitable for the study. A well-documented screening log should be present in the clinic.
A European Post-Authorisation Observational Study Of Patients With Hereditary Angioedema

This observational (non-interventional) study is being conducted to characterize the safety and use of CINRYZE in routine clinical practice when administered for (1) routine prevention of angioedema attacks, (2) pre-procedure prevention of angioedema attacks, and/or (3) treatment of angioedema attacks.


Eligibility Criteria:
Inclusion Criteria

All patients must:

* Have a diagnosis of HAE and be receiving CINRYZE for prevention or treatment of angioedema attacks
* Provide written informed consent/assent in compliance with applicable country-specific and local regulations

Exclusion Criteria

All patients must not:

* Be receiving CINRYZE in an investigational study
* Be receiving another HAE therapy as part of a clinical trial
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association

The goal of this project, is to better understand the fluctuation of the level of uric acid in traumatized patients by making serial measurements during their hospitalization in the intensive care unit. In addition, the determinants (e.g. type of trauma, diseases, interventions) of the blood level of uric acid and its association with the development of organ failure will be sought.


Eligibility Criteria:
Inclusion Criteria:

* Direct admission to trauma center
* ≤ 3h after trauma
* ISS ≥ 16
* Received at least 1L of fluid at ER entrance

Exclusion Criteria:

* Isolated head injury
* Isolated spine injury
* Chemotherapy within the last month
* Hematologic disease
* Chronic hemodialysis
* Uricase treatment within the last week
* Expected death within 48h
A Study of Bortezomib as Consolidation Therapy in Patients With Multiple Myeloma

The purpose of this study is determination of the event-free survival with and without Bortezomib consolidation therapy from the day of the first chemotherapeutic, myeloma-specific therapy measure, up to the occurrence of progression/recurrence or up to the occurrence of death.

This is a two-arm (group), open-label (all people know the identity of the intervention), prospective (a study in which the patients are identified and then followed forward in time for the outcome of the study) randomized (the study medication is assigned by chance), multi-center study. Approximately 385 patients will be enrolled in this study. Patients will be randomly assigned to treatment or observation group in a ratio of 1:1. The study duration from screening up to the study end is up to 27 weeks. Then the patients will be observed until the last included patient has completed a 30 month post observational phase. The patients in the treatment arm will receive 4 cycles of a therapy. Each cycle lasts for a 35 days. Safety evaluations will include assessment of adverse events, vital signs, physical examination, electrocardiograms, and clinical laboratory tests.

Eligibility Criteria:
Inclusion Criteria:

* Patients with multiple myeloma with prior therapy consisting of remission induction therapy and high dose chemotherapy followed by stem cell transplantation
* Women must be postmenopausal or using safe contraception methods
* Creatinin clearance has to be higher than 30 ml/min and whole blood count has to be within acceptable ranges

Exclusion Criteria:

* No asecretory multiple myeloma
* History of allergic reactions to bortezomib or mannitol
* Expected life expectancy of less than 3 months
* No other malignant disease beside basalioma either existing or history of
* No history of severe cardio-pulmonary disease
* Seizures
CYP2C19 Variants and Limonene Metabolism

The investigators will examine whether a non-invasive screening tool for CYP2C19 genetic variants can be developed by measuring limonene metabolism.

Cytochrome P450 2C19 is an important enzyme that metabolizes many drugs. However, individuals with genetic variants of CYP2C19, such as CYP2C19\*2 and CYP2C19\*3, are poor metabolizers of these drugs. Therefore, it is of interest to determine whether the investigators can develop a non-invasive assay to identify genetic variants of CYP2C19 by using a substrate for CYP2C19 found in citrus fruit, limonene. The purpose of the study is to examine changes in limonene levels in human breath after drinking orange peel extract for people with CYP2C19\*2 and CYP2C19\*3 genetic variants versus those that do not.

Eligibility Criteria:
Inclusion Criteria:

* Age range: Greater than 18 years and less than 45 years.
* Gender: Male or Female
* Ethnicities: East Asian

Exclusion Criteria:

* Pregnant and/or Breastfeeding
* previous allergic reaction to limonene, citrus fruits, bovine gelatin, glycerin
* past medical history of cerebrovascular or cardiovascular disease
* veganism
* history of chest pain or shortness of breath in the past month
* certain medications that are CYP2C19 substrates or CYP2C19 inhibitors
* Non-East Asian descent
* age less than 18 y.o or age greater than 45 y.o
Usage, Usability & Effect on Adherence and Clinical Outcomes of Text Message Reminders for Adolescents With Asthma

The purpose of this randomized crossover study is to determine the efficacy of participant designed medication reminders on asthma control, asthma related quality of life,and medication adherence. In addition, this study will provide data regarding the usage, usability, acceptability of an online system designed for creating text message reminders. It is hypothesized that the teens receiving text message reminders will report having greater quality of life related to their asthma, a reported increase in the control of their asthma, and increased adherence to their medication regimen compared to those teens that are not receiving the text message reminders.

Adolescents are typically less adept at managing chronic illnesses and adhering to treatment plans than are parents of younger children. Adolescents are also typically "early adopters" to technological solutions and text messages are integral in today's teen culture. Text messages are gaining acceptance in health care both as appointment reminders and direct inquiries. The purpose of this randomized crossover study is to examine the effect of participant designed medication reminders on asthma control, asthma related quality of life, and medication adherence. In addition, this study will provide data regarding the usage, usability, and acceptability of an online system designed for creating text message reminders.

Eligibility Criteria:
Inclusion Criteria:

* Between the ages of 12 and 22
* Diagnosis of Persistent Asthma
* Receiving care at Cincinnati Children's Hospital Medical Center or affiliate
* Prescription of a controller medication
* Must have a cell phone that receives text messages
* Asthma is not well-controlled based on ACT score
* English Speaking

Exclusion Criteria:

* No diagnosis of persistent asthma
* Receiving asthma care other than at a Cincinnati Children's Hospital Medical Center or affiliate
* Asthma is well-controlled based on ACT score
* Does not have a cell phone that receives text messages or plans to change phones within the next 6 months
* Is not taking a daily asthma controller medication
* Is currently receiving asthma appointment or medication reminder text messages from another source
Tilt of the Intraocular Lens in Patients Undergoing Combined Phacoemulsification and Vitrectomy With Airtamponade

Vitrectomy with membrane peeling has developed to be the gold-standard in treatment of epiretinal membranes. Due to the possibility of vitrectomy induced cataract, in many ophthalmic surgical centers it has become usual to indicate combined phacoemulsification and vitrectomy in case of existing cataract.

Epiretinal membranes (ERM) and pseudomaculaforamen are disorders involving the posterior pole of the eyeball with consecutive vision loss. ERM can be well visualized with spectral domain optical coherence tomography (SD-OCT). Different study groups showed that even intraoperative use of SD-OCT is possible.

The aim of the study is to document tilt of the intraocular lens in combined phacoemulsification and vitrectomy by photography of purkinjereflexes. During vitrectomy tamonade with air or saline are regarded as equal in substituting the removed vitreous. In case of airtamponade, air will be resolved within several days. As airtamponade induces more anterior movement of the implanted intraocular lens in the superior parts of the lens, tilt can result. Saline doesn´t have any influence on the intraocular lens.

Eligibility Criteria:
Inclusion Criteria:

* patients sheduled for combined phakoemulsification and 23G pars plana vitrectomy
* Minimum Age of 21 years
* written informed consent

Exclusion Criteria:

* none