cyrilzakka/clinical-trials huggingface dataset:
MyBehavior: Persuasion by Adapting to User Behavior and User Preference

MyBehavior is a mobile application with a suggestion engine that learns a user's physical activity and dietary behavior, and provides finely-tuned personalized suggestions. To our knowledge, MyBehavior is the first smartphone app to provide personalized health suggestions automatically, going beyond commonly used one-size-fits-all prescriptive approaches, or tailored interventions from health-care professionals. MyBehavior uses an online multi-armed bandit model to automatically generate context-sensitive and personalized activity/food suggestions by learning the user's actual behavior. The app continually adapts its suggestions by exploiting the most frequent healthy behaviors, while sometimes exploring non-frequent behaviors, in order to maximize the user's chance of reaching a health goal (e.g. weight loss).

A dramatic rise in self-tracking applications for smartphones has occurred recently. Rich user interfaces make manual logging of users' behavior easier and more pleasant; sensors make tracking effortless. To date, however, feedback technologies have been limited to providing counts or attractive visualization of tracked data. Human experts (health coaches) have needed to interpret the data and tailor make customized recommendations. No automated recommendation systems like Pandora, Netflix or personalized search for the web have been available to translate self-tracked data into actionable suggestions that promote healthier lifestyle without needing to involve a human interventionist.

MyBehavior aims to fill this gap. It takes a deeper look into physical activity and dietary intake data and reveal patterns of both healthy and unhealthy behavior that could be leveraged for personalized feedback. Based on common patterns from a user's life, suggestions are created that ask users to continue, change or avoid existing behaviors to achieve certain fitness goals. Such an approach is different from existing literature in two important aspects: (1) suggestions are contextualized to a user's life and are built on existing user behaviors. As a result, users can act on these suggestions easily, with minimal effort and interruption to daily routines; (2) unique suggestions are created for each individual. This personalized approach differs from traditional one-size-fits-all or targeted intervention models where identical suggestions are applied for groups of similar people or the entire population.

Eligibility Criteria:
Inclusion Criteria:

* In relatively healthy condition. Also, users must be interested in health and fitness.

Exclusion Criteria:

* Individuals with physical disability and dietary problems are excluded.
Home-based -Virtual Reality Intervention for Stroke Rehabilitation

On-going rehabilitation is needed to maintain and improve the weaker upper extremity following stroke. Community rehabilitation programs for stroke individuals in the chronic stage are often difficult to be implement. Consequently, many individuals remain without structured interventional programs. Self-training programs, where individuals can independently continue to exercise at home, might answer this challenge. However, since exercising alone is boring and not motivating, individuals often stop the prescribed exercises and remain inactive. The use of video-games for self-training might answer this challenge.

Therefore, the investigators aimed to assess the feasibility of using video-games for self-training after stroke. Specifically the investigators aim to compare the (1) training time, (2) satisfaction and (3) effectiveness of a self-training program using video-games compared to a traditional self-training program.

This is a single-blind randomized controlled trial with four assessments; two before and two following the 5-week self training intervention.

Individuals are requested to perform the self training (video-games or traditional exercises) 60 minutes a day for 5 weeks.

Eligibility Criteria:
Inclusion Criteria:

* 6 to 36 months after stroke onset
* lived in the community with family or a caregiver
* mild to moderate weakness the affected upper extremity
* without significant cognitive deficit
* able to walk at least 10-meters (with or without assistance).

Exclusion Criteria:

* Other neurological conditions
* Epilepsy
Interphase Gap in Biphasic Stimulation in DBS for ET

Deep Brain Stimulation (DBS) is a well established therapy in medication-refractory essential tremor (ET). Since the inception of DBS, cathodic pulses are used. Recent work suggests that biphasic pulses influence the therapeutic window when compared to cathodic pulses, when tested acutely. Animal studies and work from cochlear implants, show that the use of an interphase gap, influences the generation of action potentials. In this study, the goal is to investigate the use of an interphase gap in biphasic pulses in DBS for ET patients.


Eligibility Criteria:
Inclusion Criteria:

* Patients with essential tremor treated with Vim-DBS
* Normal impedances of DBS circuit
* Signed written informed consent

Exclusion Criteria:

* Active psychiatric disease or active alcohol or drug abuse
* Dementia
* History of recurrent or unprovoked seizures
* Relevant comorbidities that influence objective clinical assessment
* Pregnancy
Occurrence of Adverse Effects With Immune Checkpoint Inhibitors Between a Single and Double Dose Regimen

This is a retrospective evaluation of the impact of a double dose regimen of immunotherapy use in cancer treatment compared to the single-dose regimen on the occurrence of clinically significant adverse events.

The aim of this study is to provide evidence-based arguments to help clinicians to propose the best treatment regimen for each patient.


Eligibility Criteria:
Inclusion criteria:

- Any adult patient with anti-PD-1 or PD-L-1 immune checkpoint inhibitor as monotherapy

Exclusion criteria:

- age \< 18
"Pilot Study: A Comparison of the Bouquet Speculum and the Traditional 2-Bladed Speculum"

This randomized single-blinded clinical study will compare the typical 2-bladed plastic disposable vaginal speculum to the novel 5-petal Bouquet speculum on level of patient comfort, visibility of the cervix, and time length of the examination. The data will be collected via patient and provider questionnaires.

For nearly 200 years, the traditional 2-blade "Duck bill" vaginal speculum has had very little evolution in design. In past decades, there has been an increase in popularity in using the plastic speculum rather than the metal speculum. The plastic speculum has effectively the same design as the traditional metal vaginal speculum. The current 2-blade design that has been used for centuries leaves many women feeling pain or discomfort during a speculum vaginal exam. Furthermore, in obese and multiparous women, the 2-blade design often allows the lateral walls of the vagina to cave inward during the exam, preventing the provider from gaining full visibility of the cervix. Another common complaint is that the exam takes too long, which leaves patients in pain and feeling vulnerable for an extended period of time.

The novel 5-petal Bouquet vaginal speculum offers an alternative design that some have argued provides enhanced patient comfort, better visualization of the cervix, and is easier to use for the provider. This proposed study design is a blueprint that will be used to compare the Bouquet speculum to a traditional 2-blade disposable plastic speculum on patient comfort, visualization of the cervix, and ease of use for the provider. The investigators predict that the results of this study will help physicians and other medical providers provide patients with better experience, reducing or eliminating the current common complaints regarding how speculum exams are performed today.

Eligibility Criteria:
Inclusion Criteria:

* Female patients that require a pelvic exam.
* 18 years of age or older
* Having had at least one previous pelvic exam with the traditional speculum
* Consent to participate in the study

Exclusion Criteria:

- Never had a pelvic exam before
The Effect of Emotion Regulation Training on Anxiety, in College Students in Egypt

The important role of Emotion Regulation (ER) in managing stress and anxiety is well recognized. Aims: 1) assessing the level of anxiety, and the level of difficulties in emotion regulation (DER) among University Students during COVID-19, 2) investigating the effect of the emotional regulation training program on the anxiety of University Students during the COVID-19. Methods: Part I, students will be assessed for their anxiety, DER, and the general impact of COVID-19 on their lives. The students will complete Beck Anxiety Inventory (BAI) and Difficulties in Emotion Regulation Scale (DERS). Part II will be a Randomized Control Trial (RCT) using a pre-assessment and a post-assessment. A voluntary sample of students will randomly assigned to either a group that will receive emotion regulation training or a control group. The training program is an adapted version of DBT skills training. The training program will include mindfulness, emotion regulation, and problem-solving skills through eight 90- min group sessions.


Eligibility Criteria:
Inclusion Criteria:

* Being an active student at the University

Exclusion Criteria:

1. Receiving treatment at the hospital during the time that the study was in progress
2. Having been diagnosed with psychotic disorders
3. Having mental retardation
Do Low High Density Lipoprotein (HDL) Levels Predict Treatment Outcome in Patients With Chronic Hepatitis C Viral Infection?

The working hypothesis is that the low HDL serum level predict favorable response to anti viral treatment in chronic HCV (genotype 1) viral infection. This might be used to improve the rate of sustained virologic response.

Lipoproteins are closely connected to the process of hepatitis C virus (HCV) infection. Metabolic syndrome predicts negative treatment outcome in HCV infection.

Aim: to assess the association between lipids components of the metabolic syndrome and sustained viral response (SVR).

Eligibility Criteria:
Inclusion Criteria:

* Chronic HCV genotype 1 naive patients

Exclusion Criteria:

* Co infection with HBV, HIV, HDV
* Decompensated liver disease
Enhancing Cognitive Abilities With Comprehensive Training

The purpose of this study is to measure the efficacy of an online cognitive training program against an active control condition in a large, randomized trial.

The present study aims to evaluate a targeted, progressively challenging, online cognitive training program comprised of 49 distinct exercises targeting a variety of cognitive capacities. The cognitive training program will be compared to a plausibly beneficial active control condition in which participants completed online crossword puzzles.

The investigators hypothesize that the cognitive training will show greater transfer to a range of underlying cognitive abilities than the active control, as measured by a broad battery of neuropsychological assessments and participant-reported outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Engaged with the Lumosity program at least 3 days in the first week after sign-up
* Access to an internet enabled computer to complete training

Exclusion Criteria:

* Paying subscriber
General Surgery Residency Training in Low Income Countries

The general surgery residency program was initiated in 2013 between Istanbul Medeniyet University and Benadir University. A formal training program was established that covered 3-year theoretical and practical training that would form the structure of academic, clinical and technical criteria by evaluating all the requirements of the surgical residency training. A resident logbook was prepared to track exam results, practices, knowledge and skill status that the residents achieved in the training process. Candidates who graduated from medical school and were successful in the multiple-choice exam consisting of basic and clinical sciences were accepted to the program each year in different numbers according to the capacity. From the initiation, 16 surgeons -9 in 2016, 3 in 2017 and 4 in 2018- graduated from the program. This study was designed after the last resident group graduated and worked as an attending surgeon at least for a year.

The data were collected from graduates who were working as surgeons in Somalia to reveal the features and numbers of elective, emergency, trauma, and non-general surgical interventions performed in a month. A questionnaire consisting of pathology, type and numbers of interventions performed in one month by graduate surgeons (GS), including general surgery and other specialties, was prepared.

Eligibility Criteria:
Inclusion Criteria:

1. surgeons who completed program
2. surgerons who currently working as an attending physician in Somalia

Exclusion Criteria:

1. surgeons who has not completed program
2. surgeons who did not completed the questionare
Comparative Validation of "Blinq" and "2WIN" Vision Screeners

After 28 years of development, the binocular birefringence screener ("blinq," "Rebion") was commercially released. It need to be validated with AAPOS (American Association for Pediatric Ophthalmology and Strabismus) criteria in part because the next Uniform Standards document is pending.

Adult and children pediatric and strabismus patients were screened with blinq and "2WIN" photoscreener with "CR" corneal reflex alignment test and then compared to confirmatory exam with age-appropriate determination of binocular status.

As a part of a new or follow-up comprehensive eye examinations, patients were screened with two novel objective devices according to AAPOS Uniform guidelines. Following the refractive, alignment and sensory testing, cycloplegic refraction was performed 30 or more minutes after cyclopentolate 1% drops. In cooperative patients, sensory tests including Worth 4-dot, Stereo Fly and "PDI Check" were performed to characterize binocularity. For younger patients, binocular function was estimated by Bruckner Test, 4- base out prism cover and the CR corneal reflex component of "2WIN" photoscreener ("Adaptica," Padova Italy).

Each patient was screened with a recently commercially released blinq screener according to manufacturer's recommendations. If an initial interpretation of "pass" or "refer" was not achieved, then repeat efforts with "timed out" or "inconclusive" were accomplished and results evaluated as if a "refer." An example of blinq birefringent screening is shown in \[video\].

Patients were screened with the binocular infrared autorefractor "2WIN" according to manufacturer guidelines. Refractive referral criteria were not age-stratified.

The "Rebion blinq" is a unique screening method and therefore we sought to provide appropriate validation. In addition to non-age stratified AAPOS 2003 Uniform guidelines, we collected all cases characterized by constant or persistent strabismus whether large- or small angle employing cover test, 4 base out test, Bruckner Test and "2WIN CR" function. We did not employ any method of retinal videographic analysis of fixation instability.

De-identified patient data recorded for sharing on study website.

Eligibility Criteria:
Inclusion Criteria:

Children in Pediatric Ophthalmology Practice Adult strabismus patients

-

Exclusion Criteria:

patients with enucleations patients with eviscerations patients with exenterations

-
Phase II Clinical Trial of Clenbuterol in Adult Patients With Pompe Disease

The goals of this study are to determine safety and efficacy with regard to motor function of oral clenbuterol in combination with ERT in subjects with LOPD


Eligibility Criteria:
Inclusion Criteria:

1. Diagnosis of Pompe disease by blood Acid alpha-glucosidase (GAA) assay and GAA gene sequencing,
2. Age: 18+ years at enrollment,
3. Receiving enzyme replacement therapy (ERT) at a stable dose for \>104 weeks,
4. FVC \>15% of expected (supine).
5. Subjects are capable of giving written consent.
6. Able to walk at least 100 meters on the 6 minute walk test (6MWT) (with assistive devices permitted).

Exclusion Criteria:

1. Continuous invasive ventilation (via tracheostomy or endotracheal tube)
2. 6MWT distance \>90% of expected performance (% expected)
3. FVC \>90% of expected (upright).
4. Clinically relevant illness within two weeks of enrollment including fever \> 38.2o C, vomiting more than once in 24 hours, seizure, or other symptom deemed contraindicative to new therapy.
5. Chronic heart disease (Myocardial infarction, arrythmia, cardiomyopathy)
6. Tachycardia
7. History of seizure disorder
8. Hyperthyroidism
9. Pheochromocytoma
10. Pregnancy
11. History of diabetes
12. History of hypersensitivity to β2-agonist drugs such as albuterol, levalbuterol (Xopenex), bitolterol (Tornalate), pirbuterol (Maxair), terbutaline, salmeterol (Serevent),
13. Patients on a non-standard schedule for ERT; for example, weekly infusions as opposed to infusions every two weeks.
14. Treatment for asthma in the previous 12 months.
15. Renal insufficiency (elevated serum creatinine).
16. Having started respiratory muscle strength training in the last 6 months prior to study day 1 or having discontinued respiratory muscle strength training in the 6-month period preceding study day 1, or having started respiratory strength training greater than 6 months prior to study day 1 and unwilling to continue for the first year of study participation.
17. Received an investigational drug or participated in another interventional study within 90 days of Study Day 1.
18. Anti-rhGAA IgG with sustained titer \>1:25.600 for \>6 months at time of enrollment.
19. The use of the following concommitant meds is prohibited during the study:

    * diuretics (water pill);
    * digoxin (digitalis, Lanoxin);
    * beta-blockers such as atenolol (Tenormin), metoprolol (Lopressor), and propranolol (Inderal);
    * tricyclic antidepressants such as amitriptyline (Elavil, Etrafon), doxepin (Sinequan), imipramine (Janimine, Tofranil), and nortriptyline (Pamelor);
    * Monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate); or
    * other bronchodilators such as albuterol, levalbuterol (Xopenex), bitolterol (Tornalate), pirbuterol (Maxair), terbutaline (Brethine, Bricanyl), salmeterol (Serevent), isoetherine (Bronkometer), metaproterenol (Alupent, Metaprel), or isoproterenol (Isuprel Mistometer).
Clinical, Neurophysiological and Neuroendocrine Effects of Aerobe Exercise in Generalized Anxiety Disorder (GAD)

This study investigate the effect of high-intense aerobe exercise training (HIT) on clinical and physiological parameters (anxiety, somatisation, cortisol, alpha amylase, "mismatch negativity", loudness dependence auditory evoked potentials) in patients with generalized anxiety disorder (GAD). Half of patients will receive HIT, while the other half will receive aerobe exercise of low intensity.

Generalized anxiety disorder (GAD) is a prevalent psychiatric condition and characterized by worrying of several topics of the daily life as well as stress-induced somatic symptoms (e.g. headache or musculoskeletal pain). Disturbed monoaminergic neurotransmission, changes in central information processing and altered levels of stress markers were reported as to be biological correlates of GAD or other stress-related disorders. Cognitive behavioral therapy is the first-line treatment in GAD, but it seems to be less effective than in other anxiety disorders. There is, however, some evidence for an anxiolytic activity of aerobe exercise. In this context, different forms of aerobe training were found to be associated with significant reduction of clinical symptoms in panic disorder, agoraphobia or social phobia as well as a normalisation of some of its pathophysiological markers.

In this study, 20 patients with GAD will receive a high-intensive aerobe training (HIT, 6 HIT-sessions of 20 minutes within a period of 12 days). Additionally, 20 GAD-patients will undergo a less intense aerobe training matched regarding frequency and duration of sessions. Prior to the first training session, after completing the training (day 12) and 30 days after baseline, symptoms of anxiety and somatisation will assessed by using established questionnaires. Moreover, saliva samples and electroencephalogram (EEG) will performed at the same times of assessment in order to evaluating changes of cortisol, alpha amylase, "mismatch negativity" and loudness dependence auditory evoked potentials.

We hypothesize, that GAD-patients which undergo HIT, will show a stronger and more sustained improvement of both, clinical symptoms and formally altered electrophysiological and endocrinological parameters.

Eligibility Criteria:
Inclusion Criteria:

* Generalized Anxiety Disorder (GAD) according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)
* Appropriate abilities to communicate and to complete the questionnaires
* Written informed consent
* Possibility of regular attendance at the training sessions

Exclusion Criteria:

* Other severe mental conditions than GAD (e.g. schizophrenia, severe depressive episode, addiction)
* Acute suicidality
* Epilepsy or other disorders of the central nervous system (e.g. tumor, encephalitis)
* Contraindications to aerobe exercise training
* Cardiovascular diseases
* Start or modification of an anxiolytic pharmacotherapy within the last four weeks
* Current psychotherapy