cyrilzakka/clinical-trials huggingface dataset:
Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest

The goal of this observational study is to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients. The main questions it aims to answer are:

* Whether the protocolized classification of cardiac arrest minimizes the proportion of unknown causes and mis-classification in young cardiac arrest patients?
* Whether the incorporation of genetic tests in the identification protocol of arrest cause helps the recognition of sudden arrhythmic death syndrome in young cardiac arrest patients?

Participants will be asked to received serial examinations including genetic analysis to explore the cause of cardiac arrest.

Out-of-hospital cardiac arrest (OHCA) is an important emergency medical issue. Although the refinement of resuscitation and post-arrest care improved the survival rate of cardiac arrest patients, the rate of survival-to-discharge is still less than 20%. The Utstein templates for cardiac arrest classified the pathogenesis of cardiac arrest into medical (presumed cardiac or unknown, other medical causes); traumatic cause; drug overdose; drowning; electrocution; or asphyxial (external). Presumed cardiac caused arrest in pre-hospital setting might turned out to be other cause after series of workup. In recent observational studies, cardiac origin arrests accounted for about 50% of OHCA. These patients had better prognosis than patients with non-cardiac causes. Identifying and correcting the persistent precipitating pathology is also a crucial element in managing post cardiac arrest syndrome.

Systemic analysis protocol, including history, electrocardiogram, laboratory exam, imaging studies, cardiac catheterization, toxicology screening, could facilitate the identification of the causes of cardiac arrest and minimize the proportion of unknown causes. In young patients, structural heart diseases and arrhythmias were also the important causes of cardiac origin arrest. Genetic tests might aid the recognition of sudden arrhythmic death syndrome in this group. This study aims to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients, and minimized the proportion of unknown causes and mis-classification.

Eligibility Criteria:
Inclusion Criteria:

* non-traumatic out-of-hospital cardiac arrest

Exclusion Criteria:

* traumatic cardiac arrest
* pregnancy
Magnesium as Adjuvant for Sciatic Block

The aim of the study is to evaluate if Magnesium added to ropivacaine can reduce onset time and can enhance offset time.

Patients are randomly divided into two groups: group "M" (Ropivacaina 7,5 mg/ml with Mg 4 mg/Kg)and group"C" (without Mg).

Standard monitoring is applied to each patient in perioperative period. An indipendent observer collect data: time to perform block, sensitivity onset,motor onset, pain during surgery and complication.

In the post-operative period till 24 hours for each patient is evaluated off-set time, pain and analgesic consumption.

Eligibility Criteria:
Inclusion Criteria:

* given consent
* allux valgus correction surgery

Exclusion Criteria:

* allergy to local anesthetic
* infection in the site of puncture
The Examination of Woman Generations' on Exercise Preferences, Body Image, Physical Activity and Social Media Use

Purpose: The aim of this study is to examine the differences in the physical activity levels, exercise preferences, body image, and social media use of the women of the X, Y, and Z generations and to determine the relationship between these parameters and the use of social media.

Method Type of study: This research is a descriptive cross-sectional study and the population of the study consists of women. Evaluations of the participants will be made in the form of an online survey via "Google Forms".

Participants: The sample size of the study was calculated using the G Power program with the One Way Anova method, with a type 1 error value of α=0.05, power (1-ß)= 0.90, and effect size (predicted)=0.25 to be at least 207 individuals. The women constituting the sample of the study will be divided into three different groups X-Y-Z according to the generations based on the stratified random sampling method.

Intervention: The groups will be compared in terms of their physical activity levels, exercise preferences, body image, body image, and their relationship with social media use will be examined. In this study, the International Physical Activity Questionnaire (IPAQ) (Short), Physical Appearance Comparison Scale-Revised (PACS-R), Sociocultural Attitudes Towards Appearance Questionnaire -4-Revised (SATAQ-4R), Body-Cathexis Scale (BCS) and Mobile health scale created by researchers in line with the purpose of the research. and Social Media Usage and Exercise Preferences questionnaire will be used.

Statistical Analysis: SPSS (Statistics Program for Social Sciences) 26.0 will be used for statistical analysis. The suitability of the data to the normal distribution will be evaluated with the Kolmogorov-Smirnov test. Descriptive statistics will be shown as mean ± standard deviation, minimum and maximum value for continuous variables, and categorical variables will be shown as frequency and percentage. Chi-square analysis will be used to compare categorical variables. The data of the 3 groups will be compared statistically. If the data has a normal distribution, parametric tests will be preferred, and if the data is not normally distributed, nonparametric tests will be preferred. In all statistical analyses, p\<0.05 or 95% confidence interval will be accepted as the level of significance.

Eligibility Criteria:
Inclusion Criteria:

* Being 18 years or older
* Female gender
* Birth year range to be between 1965 and 2005
* Being a volunteer for attending the study

Exclusion Criteria:

* Having any musculoskeletal injury within 6 months
* Having any neurological, rheumatological, or cardiac problems
* Having a psychiatric illness
2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension

The objective of this project is to elucidate the effect of L-Citrulline (L-CIT) supplementation on vascular function at rest and during rhythmic handgrip exercise and functional sympatholysis via lower-body negative pressure in postmenopausal women with elevated blood pressure and hypertension.

Using a double-blind, randomized, placebo-controlled, and crossover design, overweight or obese postmenopausal women with elevated blood pressure (BP) or hypertension will receive CIT (6 grams/day) or placebo for 2 weeks, separated by a two-week washout period.

There will be a total of 5 laboratory visits. The 1st visit will take approximately 1 hour. The 2nd - 5th visits will take about 2 hours and 15 minutes. Visit 1 will be a screening visit, visits 2 and 4 will be considered baseline visits, and visits 3 and 5 will be following the participants' two weeks of supplementation. Arterial stiffness (carotid-femoral and femoral-dorsalis pedis pulse wave velocity) and endothelial function will be assessed at rest. Additionally, brachial artery blood flow, forearm muscle oxygenation, cardiovascular hemodynamics (stroke volume, cardiac output, systemic vascular resistance), and BP will be assessed at rest, during 6 minutes of rhythmic handgrip exercise at 30% of a predetermined maximal voluntary contraction, and 2 minutes of superimposed lower body negative pressure to increase sympathetic activity.

Eligibility Criteria:
Inclusion Criteria:

* Postmenopausal women (defined as the absence of menstruation for at least 1 year).
* Resting systolic blood pressure 120-150 mmHg.
* Between the ages of 50 - 70 years.
* Sedentary (\< 120 minutes of exercise/week).
* Body mass index of 25 - 39.9 kg/m2.
* Fasting glucose \< 126 mg/dL and HbA1c \< 6.5%.

Exclusion Criteria:

* Body mass index ≥ 40 or \< 25 kg/m2.
* Systolic blood pressure \> 150 mmHg.
* Taking more than two antihypertensive medications.
* Cardiovascular diseases, type I/II diabetes, musculoskeletal disorders, or cancer.
* Changes in hypertensive medication in the past three months.
* Began or changed hormone replacement therapy in the past 6 months.
* Current smoker.
* Heavy drinking (\> 7 alcoholic drinks/week).
* Participants on beta-blockers or other vasodilatory supplements (nitrates).
* Incorporated in a weight loss program and/or aerobic or resistance training program.
Functional Correlates of Bipolar Disorders and Effects of the Psychoeducation. an fMRI Study

This research project follows two main objectives: 1) Assess anatomical and functional cerebral abnormalities in bipolar disorder. 2) Evaluate anatomical and functional changes after the application of a psychoeducational program in these patients. Specifically, this project aims to assess neurophysiological (fMRI - activation and functional connectivity) and neuroanatomical (morphometry and diffusion tensor imaging) specificities related to bipolar disorders and the therapeutic response to the psychoeducation. The results of this thesis project would also contribute to the validation of a pathophysiological model of the bipolar disorder.


Eligibility Criteria:
Inclusion Criteria:

* clinical diagnosis of bipolar disorders
* euthymic (Montgomery and Asberg depression rating scale \< 10, Young Mania rating scale \< 10)

Exclusion Criteria:

* other concomitant psychiatric disorders
a Predictive Scheme for Poor Responders in IVF Cycles

While practicing the different assisted reproductive techniques, the investigators are faced daily by the problem of poor responder females, and the debate about predicting its results based on the outcome of the different ORTs used. Due to the cost of AMH as an indicator for ovarian response, the need to re-assess its role was essential in our community, which led us to conduct this prospective multi-center IVF study.


Eligibility Criteria:
Inclusion Criteria:

* normal body mass index (BMI)
* AMH from 0.5-1.1 ng/ml.
* previous history of ≤3 oocytes retrieved using conventional long stimulation protocol

Exclusion Criteria:

* Females suffering from other causes of infertility as tubal, uterine factors or known cases of endometriosis
* severe cases of male factor as azospermia
* females who were unable or not willing to participate in the study were excluded from the study.
Therapeutic Effect of the Wireless Micro Current Stimulation in Pediatric Deep Dermal Burns and Scald Injuries

This study will determine the effect of the wireless micro current stimulation in pediatric deep dermal burns and scald injuries. The clinical trial ist designed as a blinded, placebo-controlled, randomized, prospective, single-center study.

Patients (m / w) aged 0-17 years with scalding and burning injuries will initially receive polyhexanide gel 0.02% in the ordinary course.

After 24-48 hours after the accident the wound depth is measured and documented with laser Doppler imaging (see inclusion criteria).

Then the patient is enclosed into the study.

From day 3 after the accident daily dressing changes are performed with possibly slight analgesic medication (ibuprofen 10 mg / kg ) and if necessary under sedation with midazolam 0.5 mg / kg po. Here, a 30-minute-treatment with the wireless micro current stimulation or the placebo lamp is performed.

For visual support of the process of the colorless wireless microcurrent therapy / colorless placebo therapy the medical device has an additional light source (red and white color). So, in addition, both (the control and the placebo) groups are divided in one group with colorless intervention (white light) and a group with red light. The main aspect is to avoid bias.

The treated wound areas are examined daily during the dressing change by the study doctors and standardized photographed.

The condition of the wound is detected in the wound documentation module of KIS. The end point of the wireless micro current stimulation is an epithelialization of the wound surface under investigation of\> 95%. The detection of reepithelisation is performed by the investigators and objectified through a photo-image program.

At the total absence of wound healing on day 16th, the patient receives the standard surgical therapy (skin grafting).

If there is an absence of wound healing with less than 50% epithelisation after 3 weeks of wireless micro current stimulation therapy the patient will also receives the standard surgical treatment (skin graft).

If the wound-epithelialisation at day 24 is greater than 50% but not\> 95%, the wireless micro current stimulation will still be continued, but no longer than 4 weeks - until day 30.

Eligibility Criteria:
Inclusion Criteria:

* inpatients (m / w)
* wound area greater than 0.5% and less than / or equal to 3% of the body surface
* IIb ° combustion depth verified by Laser Doppler Imaging
* Burn / scalds not older than 48 hours
* Participation willingness of the patient
* willingness to participate and written informed consent of both parents (or legal guardian) of the patient

Exclusion Criteria:

* known wound healing problems
* child abuse as the cause of the combustion
* different wound dressing treatment prior to transfer to our hospital
Study of Bioactive Glass-ceramic Intervertebral Spacer (Bonglass-SS) in Posterior Lumbar Interbody Fusion

The goal of this study is to compare Bonglass-SS with titanum cage.


Eligibility Criteria:
Inclusion Criteria:

* 30\~80 aged patients needed single-level posterior Interbody fusion at L1\~S1
* A subject who provided written informed consent to participate in this study

Exclusion Criteria:

* Patitents with BMD T-score \< -3.0
* Women who are pregnant or plan to be pregnant within 3 years
* Patient with malignant tumor
REQUIP RLS Post Marketing Surveillance

post-marketing surveillance to monitor safety and efficacy of ropinirole during using of treatment for RLS

This study is a post-marketing surveillance to monitor safety and efficacy of ropinirole during using of treatment for RLS(restless leg syndrome) and identify SAEs, adverse drug reactions, and unexpected AEs not described as precautions or warnings and to identify prognostic factors that have an effect on the AEs and to assess effectiveness of ropinirole in real clinical practices after marketing. The subjects are patients prescribed for ropinirole by the investigators at the sites based on prescription information in normal clinical practices.

Eligibility Criteria:
Inclusion Criteria:

* Subjects diagnosed with RLS by the investigator
* Subjects who the investigator believes that they can and will comply with the requirements of the protocol

  * To be contactable over the phone
  * To follow the administration regimen.
* A male or female aged 18 years and more at the time of the first prescription.
* Subjects with no experience of RLS treatment using ropinirole

Exclusion Criteria:

Considering the nature of this non-interventional PMS study, there is no strict exclusion criteria set up. GSK Korea encourage the doctors participating this study to enrol the subjects prescribed with Ropinirole following the locally approved Prescribing Information (Appendix ) The following criteria should be checked at the time of study entry.

* Subjects with hypersensitivity to ropinirole and any excipients
* Female who is during the period of the pregnancy or who are lactating
Kinesio-Taping in Stroke Patients With Visuospatial Neglect

Stroke is the second leading cause of death worldwide and the third most common cause of disability. The effects of stroke are variable and may include impairments in motor and sensory systems, emotion and neuropsychological deficits such as a disorder of spatial awareness known as unilateral spatial neglect (USN). Approaches to ameliorate USN could be categorized in interventions as involving either bottom-up or top-down processing. The specific mechanisms underlying these effects on a number of manifestations of the USN syndrome may include the restoration of defective representations of the side of space contralateral to the lesion (contralesional), and of the ability to orient spatial attention contralesionally, through complex patterns of activation of both the damaged right hemisphere, and the contralateral left hemisphere, with differences related to the specific stimulation delivered to the patient. In recent years, increasing cutaneous stimuli through neuromuscular kinesiotaping has been proposed to enhance somatosensory inputs (24) and such as method could have positive effects on USN. The aim of the present study was to assess the effect of KTM applied on the sternocleidomastoid muscle controlateral side of the lesions in improving USN deficits in individuals with stroke patient in sub-acute phase. The hypothesis is that the KTM application could improved cognitive tests for assessing USN, motor deficits and kinesthetic neck sensibility.


Eligibility Criteria:
Inclusion Criteria:

* patients affected by stroke from cerebral ischemia or hemorrhage that occurred ⩽ 30 days before;
* presence of visuospatial neglect (Star Cancellation Test' score \< 50)
* able to actively rotate the head toward left side in closed eyes condition.

Exclusion Criteria:

* the presence of dementia (Mini-Mental State Examination correct score lower than 23,80)
* severe deficit of comprehension
* psychiatric disorders
* hemianopsia patients (diagnosed with perimetry) patients or their family members did not consent to this study.
Effect of Novel High Dissolving Transitional Foods

This is a prospective comparative study, where patients who meet inclusion criteria undergoing a craniofacial procedure will either be provided with novel high dissolving transitional foods for use in the post-operative period (Intervention Group) or will not be provided the food and will proceed as per current standard of care (Standard of Care Group). Both groups will be followed pre-operatively at time of pre-operative visit, and will be followed in the post-operative period, with two visits at 1 and 3 weeks post-operatively, respectively.


Eligibility Criteria:
Inclusion Criteria:

* Patients ages 0 years, 6 months to 18 years of age
* Patients with a diagnosed cleft/craniofacial condition undergoing one of the following cleft/craniofacial related surgeries in the upcoming calendar year (a-c):

  1. Cleft Palate Repair (Palatoplasty)
  2. Alveolar Bone Graft Surgery
  3. Velopharyngeal Insufficiency Surgery
* Patients who eat fully by mouth (PO)
* Patients who adhered to scheduling protocols and attended all necessary pre- and post-operative visits

Exclusion Criteria:

* Patients under the age of 6 months or over the age of 18
* Patients who utilize an NG-tube or G-tube for primary means of nutrition/hydration
* Patients who have PO recommendations from a licensed Speech-Language Pathologist that prevents their ability to consume Level 4 IDDSI (pureed) foods, including patients who are NPO.
* Patients with any diagnosed allergies to the ingredients listed on the Savorease Therapeutic Foods ingredient labels
* Patients/caregivers who are not able to participate in pre- and post-operative protocoled visits for any reason
* Patients/caregivers who are not able to respond to written questions presented in English
Predicting Pathological Response Within the 1st Week of Chemotherapy Using Diffuse Optical Spectroscopic Imaging

Women with Breast Cancer who do not respond to chemotherapy may undergo months of treatment with little or no change in tumor size or overall outcome.

The Researchers have demonstrated a previously undescribed "metabolic flare" response observed very early in neoadjuvant treatment in breast cancer patients. The research can determine that this flare is predictive of overall therapy response and is due to both an inflammatory reaction and cell death induced by cytotoxic therapy.

The researcher can use Diffuse Optical Spectroscopic Imaging device to measure and predict the markers of the response in the first weeks of chemo-therapy.

The oxyhemoglobin flare response can predictive of overall pathological response to chemotherapy in human subjects. These vascular changes can indicate the rapid transient increase and then decrease in oxyhemoglobin concentration in the first hours and days after therapeutic administration. The magnitude and time course of the flare response in patients receiving cytotoxic therapy will differ between pathological responders and non-responders. This oxyhemoglobin "flare response" can be observed In tumors where vascular dynamics are intact.

Eligibility Criteria:
Inclusion Criteria:

* Female, not pregnant, not breastfeeding
* greater than 21 years of age but less than 75 years of age
* will be receiving neoadjuvant chemotherapy for breast cancer as prescribed by their oncologist

Exclusion Criteria:

* Under 21 year of age
* Female pregnant or breastfeeding
Ablation of Pulmonary Oligometastasis Combined With System for Advanced Hepatocellular Carcinoma

Ablation has been an effective therapy in treating intrathoracic metastases. However, for hepatocellular carcinoma with pulmonary oligometastasis, ablation of metastases remains relatively unexplored and still needs clinical evidence.

Systemic therapy is the standard treatment for advanced hepatocellular carcinoma (HCC) with metastasis. However, metastases with limited number (oligometastasis) can represent a subtype and transition point between localized disease and widespread metastases. Thus, eliminating metastases could be advantageous and beneficial to the prognosis if feasible and permitted. Image-guided ablation therapy, such as microwave ablation (MWA), radiofrequency ablation (RFA), and cryoablation, has attracted great interest as a minimally invasive approach against intrathoracic metastases. Recently, ablation has been used on patients with pulmonary metastases from various cancers. This technique yields high proportions of sustained complete responses and is associated with relatively low morbidity. This multicenter study focuses on the management of ablation of oligometastasis therapy combined with systemic therapy.

Eligibility Criteria:
Inclusion Criteria:

1. diagnosis of primary HCC, confirmed histologically or clinically according to the criteria of the American Association for the Study of Liver Diseases;
2. presence of pulmonary oligometastasis, the metastases found within three month of HCC diagnosis;
3. metastases with limited five sites and no more two organs involved, with a maximum diameter of ≤5cm;
4. receipt of first-line systemic therapy for minimum of 3 months before ablation, with controlled intrahepatic tumors and no progression of metastases. Controlled intrahepatic tumors were defined as those showing a partial or stable response according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST);
5. undergone locoregional treatments, including transarterial artery chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) were included;
6. classified as Child-Pugh class A or B and having an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1;
7. no history of other malignancies.
8. life expectancy more than 3 months;
9. agreed to participated in this clinical trial;
10. Hemameba ≥3.0 x109/L, neutrophil ≥1.5x109/L, hemoglobin≥10.0 g/L, platelet≥100x 109/L, ALT; AST; bilirubin ≤1.5-fold normal, GFR≥60ml/min.

Exclusion Criteria:

1. intermediate HCC;
2. age \< 18 years or \> 75 years;
3. advanced HCC with more than five metastases;
4. no response to Lenvatinib;
5. metastases size \> 5 cm;
6. life expectancy less than 3 months.