Improving Lesion Detection in Children With Magnetic Resonance Imaging (MRI)-Negative Partial Epilepsy Using Diffusion Tensor Imaging

Focal cortical dysplasia is one of the most common lesions responsible for medically refractory epilepsy in the pediatric population. In patients with medically intractable epilepsy, surgery is the only treatment that will lead to seizure freedom. The outcome of epilepsy surgery is worse in patients when there is no lesion identified on routine structural MRI, also known as MRI-negative partial epilepsy. Diffusion tensor imaging (DTI), a novel MRI technique, can be used to evaluate the integrity of the microstructure of the white matter, even when the white matter appears normal on routine MRI.

The aims of this study are firstly to identify DTI abnormalities in the white matter of children with MRI-negative partial epilepsy and MRI-visible FCD compared to normal controls; and secondly to determine if the location of DTI identified abnormalities correlate with the epileptogenic zone as defined using magnetoencephalography (MEG) dipole clusters. Our hypotheses are firstly DTI can demonstrate the anatomic delineation of white matter abnormalities in MRI-negative partial epilepsy and the alteration in DTI indices are similar in MRI-negative partial epilepsy and MRI-visible FCD, which is the positive control; and secondly the anatomical location of DTI identified abnormalities correlate with the epileptogenic zone as defined by MEG dipole clusters. The long-term goal of this study is to improve detection of subtle lesions in children with MRI-negative partial epilepsy so as to improve the surgical outcome of these patients who undergo epilepsy surgery for seizure control.

Eligibility Criteria:
Inclusion Criteria:

MRI negative partial epilepsy group:

* Patients diagnosed with partial epilepsy according to the International League Against Epilepsy (ILAE) standard \[53\]
* MRI study reported as normal
* Age ranging from 6-18 years (DTI indices alter with myelination and the changes are most marked from birth to 4 years of age)

MRI-visible FCD group:

* Patients diagnosed with partial epilepsy according to the ILAE standard \[53\]
* Visual assessment of MRI demonstrates one or more features of FCD

  * Cortical thickening
  * Alteration in sulci and gyri pattern, including deep sulci
  * Blurring of gray-white matter transition
  * T2 signal prolongation of the cortex and subcortical white matter
  * High T1 signal in the cortex
* Age ranging from 6-18 years (DTI indices alter with myelination and the changes are most marked from birth to 4 years of age)

Normal controls:

* Subjects with no history of neurological diseases
* Age ranging from 6-18 years (most children under the age of 6 years are unable to tolerate the MR examination without general anesthesia or sedation).
* No requirement of general anesthesia or sedation

Exclusion Criteria:

* Subjects with contraindications for MR imaging (i.e. retained foreign bodies, implants)
* Subjects with claustrophobia
* Controls with a prior history of traumatic brain injury, neurological disorder, cerebral palsy, developmental delay or learning disability
* Controls who require general anesthesia or sedation