cyrilzakka/clinical-trials huggingface dataset:
Changes in Oral Vitamin K Intake for Optimization of Chronic Oral Anticoagulation: A Randomized Trial

The primary hypothesis of this trial is that changes in oral vitamin K intake, based on simple food registries, may be superior to conventional changes in doses of medications in order to stabilize chronic oral anticoagulation.


Eligibility Criteria:
Inclusion Criteria:

* Patients with any clinical indication for chronic oral anticoagulation with one INR level out of target, without a clear clinical cause for INR instability (unplanned changes in coumadin medications, other pharmacological interactions, clinical illnesses and laboratory errors).

Exclusion Criteria:

* Clinical evidence of bleeding or thrombosis.
* INR \> 4 or INR \< 1,5.
The Effect of Ketogenic Diet on Malignant Tumors- Recurrence and Progress

The aim of the study is, to study the efficacy of the ketogenic diet in delaying or preventing recurrence and tumor growth progression of patients who have been previously treated by concomitant chemoradiotherapy (6 months) for high-grade glial tumors.

It will be an open-label trial of nutritional intervention for up to 1 year. An interim analysis of the data will be carried out to assess safety, compliance and efficacy of the diet. This will be reviewed by both SHS and the Clinical trial team.


Eligibility Criteria:
Inclusion criteria:

1. Consenting adults aged ≥ 18 years.
2. Recurrent or progressive high grade glioma after failure of at least one line of standard oncological treatment.
3. Gliomatosis cerebri, including patients declining radiation treatment.

Exclusion criteria:

1. Patients with malignant tumors who are receiving treatment at the time of the recruitment.
2. Early termination - patients who will wish to stop their participation in the trial will discontinue the ketogenic diet and return to their usual diet.
Comparison of the Effects of External Focus and Internal Focus Instructions Applied Chronic Low Back Pain: RCT

Postural control methods are impaired in people with chronic low back pain. While the person maintains balance with pain relief, fear of movement and pain increase with loss of balance. It was found that externally focused exercises are more effective than internal focus exercises in terms of motor control and motor learning. To investigate the place of externally focused balance exercises in conservative treatment of target low back pain. For this purpose, approval was obtained from the clinical research ethics committee of Kırşehir Ahi Evran University, Faculty of Medicine, with the decision numbered 2022-18/163.

Focusing on the inside of the body while performing a movement is called "internal (internal focus)", focusing on the outside of the body is called "external (external focus)". Many previous studies have shown that external focus is substantially more effective than internal focus in the performance of a movement.In our randomized controlled study, there were two groups and 22 people were treated in each group. Volunteers between the ages of 18-65 who had low back pain for the last 3 months and had no musculoskeletal problems were included. Balances were evaluated with Biodex Balance Device, pain with Visual Analog Scale, performance with Physical Performance Test Battery, functional level with osvewstry disability index, posture, spinal mobility,postural endurance with spinal mouse device. 8 weeks of treatment were applied to both groups as external focus and control groups. Basically similar exercises were applied to both groups, and there were tasks in the exercises in the external focus group, and the focus were on the task other than the exercise.

The results of the study show that externally focused balance exercises are effective on dynamic balance, fall risk, stability limits, physical performance, posture, spinal mobility, and postural endurance in individuals with CLBP.

Eligibility Criteria:
Inclusion Criteria:

* Those with ongoing low back pain symptoms in the last three months (diagnosed with chronic low back pain),
* Individuals between the ages of 18-65
* Pain level 3 or more according to VAS
* Individuals who volunteer to participate in the study will be included.

Exclusion Criteria:

* Individuals with lower extremity and spine orthopedic and neurological disorders,
* Having a musculoskeletal injury in the last 9 months,
* Surgery, injection, etc. for low back pain in the last 3 months. with a history of treatment
* Those who are doing any sports activity,
* Subjects who do not cooperate well will not be included in the study. Inclusion and exclusion criteria will be the same for control group participants.
Effect of Chewing Gum and WeChat Enhanced Instructions on the Bowel Preparation Quality in Patients With Constipation

Patients with constipation are more likely to have poor bowel preparation quality due to slow gut motility and poor emptying ability. Gum chewing, as a proxy of sham feeding, is a very simple way used to accelerate gut motility. And a previous study found that enhanced instructions by WeChat could improve bowel preparation quality. Thus, investigators conducted a single-center randomized controlled trial to explore the effect of chewing gum combined with manual enhanced instructions by WeChat on the bowel preparation quality for colonoscopy in patients with constipation.

In this randomized controlled trial, consecutive outpatients with constipation for colonoscopy are screened and then randomized into two groups. All enrolled patients will receive 3 liter polyethylene glycol (PEG) for bowel preparation. Patients in the chewing gum and WeChat group (n = 75) are further advised to chew one piece of sugarless gum for 20 minutes after drinking each 1 liter PEG; additionally, they will receive enhanced instructions via WeChat before two days and one day of colonoscopy to further inform how to chew gum and highlight the importance of adequate bowel preparation. Patients in the control group (n = 75) are guided by regular instructions.

Eligibility Criteria:
Inclusion Criteria:

1. Patients undergoing colonoscopy at the Department of Gastroenterology of the General Hospital of Northern Theater Command.
2. Patients aged ≥18 years, no gender limitation.
3. Patients who sign informed consent.
4. Patients who are diagnosed with constipation.

Exclusion Criteria:

1. Patients who are pregnant or breastfeeding.
2. Patients who are allergic to polyethylene glycol.
3. Patients who are suspected with intestinal obstruction, stenosis or perforation.
4. Patients with mental illness.
5. Patients with serious heart, brain, liver, and kidney diseases.
6. Patients who use WeChat unconditionally by themselves or their family members.
7. Patients who are allergic to chewing gum related ingredients.
8. Patients with the history of colorectal surgery.
Effectiveness of Online Exercise Training in Geriatric Population During COVID-19

The aim of this study is to investigate the effectiveness of online exercise training in geriatric population whose daily life activity level decreased during COVID-19 pandemic.

The main questions it aims to answer are:

* Does online exercise training improve quality of life in the geriatric population whose daily life activity levels have decreased during the COVID-19 pandemic?
* Does online exercise training improve sleep quality in the geriatric population whose daily life activity levels have decreased during the COVID-19 pandemic?
* Does online exercise training affect depression status in the geriatric population whose daily life activity levels have decreased during the COVID-19 pandemic?
* Does online exercise training reduce the risk of falls by improving balance and functional independence in geriatric population whose daily life activity levels have decreased during the COVID-19 pandemic?
* Does online exercise training improve posture in geriatric population whose daily life activity levels have decreased during the COVID-19 pandemic?

Research data were collected by Sociodemographic Information Form, 36-Item Short Form Survey, The Pittsburgh Sleep Quality Index, Geriatric Depression Scale, Timed Up \& Go Test, and New York Posture Rating Chart.

While no application was given to the control group, study group has received an online exercise training with a structured exercise program including range of motion, stretching, and, to train full body, low intensity aerobic exercises, once a week for 10 weeks, each lasting 60 minutes.


Eligibility Criteria:
Inclusion Criteria:

* Volunteering to participate in the study
* Being over 65 years old

Exclusion Criteria:

* Having mental retardation at a level that prevents communication
* Having an uncontrollable heart and hypertension problem
* Being receiving medical treatment or rehabilitation for balance that may affect the balance level
* Having osteoporosis at a level where exercise can be considered risky
* Having a health problem where exercise is considered contraindicated
Classical Conditioning Training for Aphasia. A Telemedicine Approach.

This study aimed at investigating the suitability of a classical conditioning for the treatment of anomic disorder. In this study 12 patients suffering from pure anomia in the chronic stage of the disease underwent a word repetition training with a computerized telemedicine protocol. Each patient trained two word sets, one in a conditioned and the other in a non-conditioned training modality; a third non trained set served as control set.

In this study, a computer based word repetition protocol was administered at the distance to 12 pure anomic patients in the chronic stage of the disease. The to be repeated words were presented alongside the corresponding pictures. The timing of word and picture presentation was manipulated in order to investigate the suitability of classical conditioning to reteach the association between pictures and their names. Data were analyzed at the group and at the single subject level with the aim of establishing the relative efficacy of the conditioned and non-conditioned word-repetition modality and the cognitive features predicting therapy success. In keeping with preliminary results obtained on a single case study, conditioning turned out to improve therapy gain at the group level. Moreover, hints were found suggesting less generalization to untreated words in conditioned compared to non-conditioned training. Non-word repetition skills was the only feature in the participants cognitive profile which was reliably linked to the therapy outcome.

Eligibility Criteria:
Inclusion Criteria:

* Aphasic patients with word finding difficulty
* Must be able to repeat single words

Exclusion Criteria:

* Severe cognitive impairment
* Impaired single word comprehension
Endoscopic Breast Conserving Surgery With Intra-operative Navigation System

A growing number of Chinese breast cancer patients are diagnosed at a young age. The quality of life of young breast cancer patients has been a critical issue. Breast-conserving surgery (BCS) not only removes the tumor but also maintains the appearance of breast. The Breast Tumor Center of Sun Yat-sen Memorial Hospital is one of the first departments in China to perform breast-conserving surgeries. Endoscopic breast surgery has emerged as a promising surgical approach. However, it is hard to delineate the tumor margins in endoscopic BCS, which restrains its development. In traditional BCS, surgeons determine the tumor border by palpation, which is impossible in endoscopic BCS. For the first time, we performed the intra-operative navigation system-assisted endoscopic breast-conserving surgery, in which the tumor border was accurately delineated using the navigation system.

In the study, patients who are female aged between 18 and 70 years, are pathologically diagnosed operable breast cancer, have proper the important organ functions and adjust to the criteria of endoscopic breast conserving surgery. Intraoperative and post-operatitive Margin Assessment will be the primary outcome measure, and aesthetic outcomes, reoperation rate, as well as patients' feedback will be the secondary outcome measure.

Eligibility Criteria:
Inclusion Criteria:

* Signed the informed consent.
* Female aged between 18 and 70 years.
* Pathologically diagnosed operable breast cancer.
* The important organ functions meet the following criteria:

WBC \>=3.0 x 10\^9/L; Neutrophilic granulocytes \>=1.5×10\^9/L; Platelet \>=100 x 10\^9/L; Hb \>=9 g/dL;

* Total bilirubin no more than 1.5 times the normal upper limit (ULN); AST and ALT no more than 1.5 times ULN; AKP no more than 2.5 times ULN;
* Serum creatinine no more than 1.5 times ULN or Clearance rate of creatinine \>= 60ml/min;
* Thyroid stimulating hormone (TSH) \<= ULN (T3, T4 levels need to be detected simultaneously if abnormalities, the patient can be included if T3, T4 levels is normal);LVEF basement \>= 50%.
* Adjust to the criteria of endoscopic breast conserving surgery.

Exclusion Criteria:

* Multifocal or multicentric disease.
* Diffused calcifications with fine plemorphic or fine linear or fine-linear branching morphology.
* Women in the early or intermediate stage of pregnancy;
* Prior history of breast radiation;
* Any severe comorbidities, inability to give informed consent or unavailability for follow-up.
Data Collection Study to Review Novel Methods for Diagnosing Obstructive Sleep Apnea

This study will collect data on a range of signals such as facial scans, videos (including speaking, blinking and swallowing) and heart rate variability to assess whether any of these measures are useful for diagnosing obstructive sleep apnea


Eligibility Criteria:
Inclusion Criteria:

Adults aged \>= 18 Ability to read and comprehend English

Exclusion Criteria:

* Previous diagnosis of OSA
* Respiratory diseases (such COPD, lung cancer, fibrosis of the lungs, lung injury)
* Subjects who are or may be pregnant, breastfeeding or within 6 weeks postpartum (which may impact HRV temporarily)
* Subjects with a pacemaker
Menstrual Wellbeing in Woman Living in Turkey; an Epidemiological Study

Women with endometriosis in our country and around the world face various difficulties during their menstrual periods in reproductive age. While some of these difficulties are caused by the environment, some of them are due to the insufficient development of personal consciousness. In our study, we aim to reveal the perspective of individuals and society on the menstrual period. Our primary aim in our study is to understand what kind of problems are experienced in different regions of our country during the menstrual period for women and how they are spent. Secondly, the effect of this period on women's quality of life will be examined.

Our research will be conducted between January 1, 2022, and February 1, 2022, in 7 different regions of our country, by asking questions to women of reproductive age from different groups. Each participant will be asked to answer the survey questions and the results will be analyzed. The survey will be done face to face. The questionnaire contains questions about women's socio-demographic data, their perspectives on their menstrual period, their information about endometriosis, and their perspectives on pads and birth control pills. Menstruating women of reproductive age between the ages of 18- 45 will be included in this study. As a result of the study, the problems experienced by women of reproductive age in different regions will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

* Menstruating women of reproductive age between the ages of 18- 45 will be included in this study.

Exclusion Criteria:

* Women with a history of hematological disease, cardiovascular disease, malignancy, advanced renal failure, active infection, diabetes mellitus, and pregnant women will not be included in the study.
Doppler Ultrasound for Prediction of Reversibility of Acute Kidney Injury in Septic ICU Patients

Purpose: The aim of this study was to assess the ability of early discrimination between transient and persistent Acute Kidney Injury (AKI) using the color Doppler Ultrasound derived Renal Resistive Index (RI) and semi-quantitative evaluation of intra-renal vascularization in septic patients in an Intensive Care Unit (ICU).

Methods: Prospective observational cohort study with unselected, with 32 adult consecutive septic patients. Patients were divided into 3 groups: Group 1: patients without progression to AKI, Group 2: transient AKI, Group 3: persistent AKI.

Purpose: The aim of this study was to assess the ability of early discrimination between transient and persistent AKI using the color Doppler Ultrasound derived Renal Resistive Index (RI) and semi-quantitative evaluation of intra-renal vascularization in septic patients in an Intensive Care Unit (ICU). Additionally, the investigators aimed to identify whether these indexes are early predictors of the prognosis of renal function in this group of patients. And compare the diagnostic accuracy of those and other renal indexes for the identification of AKI reversibility.

Methods: This was a prospective observational cohort study with unselected, consecutive septic patients included. Thirty-two adult septic patients hospitalized in a general ICU were studied. After the determination of sepsis, patients were divided into 3 groups: Group 1 included patients without progression to AKI, Group 2 included patients with transient AKI and Group 3 patients with persistent AKI.

Eligibility Criteria:
Inclusion Criteria:

* Septic patients in ICU
* Age 18 years or older

Exclusion Criteria:

* ICU stay less than 3 days
Accuracy of BabySat V3 With Profound Hypoxia and Motion

Performance testing of pulse oximeters. The protocol involves brief stable arterial oxygen desaturation in healthy volunteers and sampling arterial blood when a stable level of hypoxia has been attained and during different motion scenarios. The blood sample is analyzed for oxygen saturation with a gold standard bench CO-oximeter. This protocol is aligned with the latest ISO and FDA guidance documents for pulse oximeter testing.


Eligibility Criteria:
Inclusion Criteria:

* The subject is male or female, aged ≥18 and \<50
* The subject is in good general health with no evidence of any medical problems
* The subject is fluent in both written and spoken English
* The subject has provided informed consent and is willing to comply with the study procedures

Exclusion Criteria:

* The subject is obese (BMI\>30).
* The subject has a known history of heart disease, lung disease, kidney or liver disease.
* Diagnosis of asthma, sleep apnea, or use of CPAP.
* Subject has diabetes.
* Subject has a clotting disorder.
* The subject a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation.
* The subject has any other serious systemic illness.
* The subject is a current smoker.
* Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly.
* The subject has a history of fainting or vasovagal response.
* The subject has a history of sensitivity to local anesthesia.
* The subject has a diagnosis of Raynaud's disease.
* The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).
* The subject is pregnant, lactating or trying to get pregnant.
* The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures.
* The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.
Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery

The purpose of this study is to compare two medications that reverse muscle paralysis at the end of kidney transplant surgery with the goal of reducing residual muscle weakness and insufficient respiratory function after surgery.

This is a prospective randomized double-blind single center study on patients with severe kidney failure undergoing kidney transplantation surgery. Patients will have their muscles paralyzed during general anesthesia for surgery. At the end of surgery, muscle paralysis will be reversed with either neostigmine (control group) or sugammadex (intervention group). Residual muscle weakness and respiratory function will be monitored after surgery with a quantitative train-of-four (qTOF) monitor and a noninvasive continuous ventilation monitor. The investigators hypothesize that patients receiving sugammadex will have less residual muscle weakness and better respiratory function than patients receiving neostigmine. Respiratory and kidney function parameters and any adverse events will be collected during the hospital stay. Patients will contacted for a study follow up around 2 weeks after their surgery.

Eligibility Criteria:
Inclusion Criteria:

* At least 18 years or older
* Diagnosed with severe kidney dysfunction (defined by plasma creatinine clearance \<30 mL/min)
* Planning on kidney transplantation surgery at the University of Colorado Hospital.

Exclusion Criteria:

* Patients unable to sign the informed consent
* Pregnant women
* Body Mass Index (BMI) \> 40 kg/m2
* Pre-existing oxygen or ventilatory dependency (24h use of oxygen or other noninvasive or invasive ventilatory support)
* Patients with any pulmonary, neuromuscular or other disease that severely limits their respiratory functional status (e.g. unable to achieve 4 Metabolic Equivalent of Tasks, METs, such as climbing up 1 flight of stairs)
* Presence of any contraindication for any of the study-related medications or interventions.
Well-being and Stress Control After Colorectal Surgery

The criteria usually considered to evaluate the quality of life are the presence or absence of a stomy, alteration of the transit or the sexual dysfunctions. Quality of life has been improved by introducing an Enhanced Postoperative Rehabilitation Program After Surgery (ERAS). It is a multidisciplinary medical and paramedical care aimed at minimizing the sources of stress allowing a significant reduction in postoperative complications and length of stay.

However, the emotional feelings of patients, their fatigue, the quality of their relationships with others and their experience of the disease are not usually considered. Nevertheless, these criteria influence the quality of life and constitute the fundamental bases of the psychological well-being, essential in the recovery processes.

We propose to enrich the ERAS program by introducing an individualized support of well-being and stress management aimed at increasing the quality of life of patients. The purpose is to make the patient more autonomous by allowing him/her, to implement stress management exercises.

The main goal of the project is to improve the psychological well-being of patients operated on for colorectal cancer by offering stress management sessions in order to promote postoperative rehabilitation.

The secondary objectives are to demonstrate the impact of stress management sessions on the length of stay and to study the link between the efficiency of these sessions and the quality of life of patients before the surgery.


Eligibility Criteria:
Inclusion criteria:

* Patient undergoing colorectal cancer surgery
* Regulated surgery
* With or without radiation treatment and / or preoperative chemotherapy.
* Patient benefiting from a social protection scheme

Exclusion criteria:

-- Limitation of linguistic or cognitive abilities interfering with the understanding of the study protocol

* Absence of the consent form of the study
* Emergency surgery
* Stomy closure
* Patient diagnosed psychotic.
* Patient with "psychiatric disorder" left to the discretion of the investigator