Vaccination for the Treatment of Previously Untreated or Relapsed Follicular Lymphoma

The purpose of this study is to compare the safety and immune activity of three doses of tumor vaccine. In recent years, researchers at the Dana-Farber Cancer Institute have discovered that vaccines made from patient's own cancer cell, that have been engineered in the laboratory to produce a protein called GM-CSF, can be effective in stimulating a powerful immune response specific to that cancer. GM-CSF is a naturally occuring hormone in the body that helps our immune system fight infections and diseases. One of the goals of this study is to determine whether these vaccinations will improve the immune system's ability to recognize and destroy the participant's lymphoma cells.

* The dose of vaccine will depend upon how many of the participant's own tumor cells are available and at which point they join study. This Phase I trial is a "dose escalation" study. This means that participants will be enrolled in groups. Group 2 will receive a larger dose than Group 1. Group 3 will receive a larger dose than Group 2.
* The vaccine is administered in injections under and into the skin six times. Participants will receive vaccination shots once weekly for 3 vaccines, then every other week for 3 vaccines.
* After the first and fifth vaccinations, a small amount of the participants own lymphoma cells (killed) will be injected under the skin to see if their immune system will react against it and cause redness and swelling. A punch skin biopsy will also be performed at these injection locations.
* During the course of the study, we will also be drawing blood to evaluate immune cells and the effect that the vaccinations have on the participants immune system. During all treatment cycles a physical exam and questions about the participants general health will be performed.
* After the final treatment (approximately week 10) the participant will undergo "re-staging" to assess the status of their disease. If after completion of six vaccines, evaluation of the participant's disease reveals that it is stable or responding to the vaccine, and there is still vaccine available, they may be eligible to continue to receive the vaccines every two weeks until their supply runs out.
* After completion of the vaccinations, participants will come back for physical exams and blood tests every 3 months for 1 year and then once a year for fifteen years to monitor the effects of the vaccine.

Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed follicular lymphoma
* Patients with relapsed follicular lymphoma achieving at least a PR following their most recent systemic chemotherapy and/or immunotherapy regimen.
* Lymphoma accessible for sampling or existing cryopreserved lymphoma tumor judged suitable for vaccine preparation.
* 4 weeks must have elapsed between the completion of the the last chemotherapy, immunotherapy, glucocorticoid therapy, radiotherapy, or experimental therapy.
* ECOG Performance Status 0 or 1
* Estimated life expectancy of \> 6 months
* 35 years of age or older
* Adequate recovery of drug related toxicities, surgery or radiation therapy
* Greater than 6 months since autologous stem cell transplantation
* Laboratory parameters as outlined in the protocol

Exclusion Criteria:

* Uncontrolled active infection or illness
* Psychiatric illness/social situation that would limit study compliance
* Pregnancy or nursing mothers
* Evidence of infection with HIV or viral hepatitis
* Other invasive malignancy
* Existing autoimmune cytopenia
* Previous allogeneic stem cell transplant
* Pre-existing autoimmune disease requiring anti-inflammatory therapy
* Participation in previous vaccine trial
* Any component of grade 3 follicular lymphoma or transformed follicular lymphoma