Ixabepilone in Treating Patients With Relapsed or Refractory Lymphoproliferative Disorders

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of ixabepilone in treating patients who have relapsed or refractory lymphoproliferative disorders.

OBJECTIVES:

Primary

* Determine the frequency and duration of complete and partial response rates for patients with relapsed or refractory indolent lymphoproliferative disorders treated with ixabepilone.

Secondary

* Determine the time to progression and overall survival of patients treated with this drug.
* Determine the toxicity of this drug in these patients.

OUTLINE: This is an open-label study.

Patients receive ixabepilone IV over 1 hour weekly for 3 weeks. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.

PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study within 1-1.5 years.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Histologically confirmed relapsed/recurrent or refractory indolent lymphoproliferative disorder of 1 of the following types:

  * Chronic lymphocytic leukemia

    * Absolute lymphocytosis greater than 5,000/mm\^3
    * B-cell phenotype (CD 19, 20, or 23 positive) with more than 30% bone marrow lymphocytes
  * B-cell small lymphocytic lymphoma
  * Marginal zone B-cell lymphoma
  * Grade I-III follicle center cell lymphoma
  * Waldenstrom's macroglobulinemia
  * Mantle cell lymphoma
* At least 1 unidimensionally measurable lesion for patients with non-Hodgkin's lymphoma

  * At least 2 cm by conventional techniques
* No active brain metastases

  * Treated CNS disease allowed

PATIENT CHARACTERISTICS:

Age

* 18 and over

Performance status

* Karnofsky 60-100%

Life expectancy

* At least 3 months

Hematopoietic

* Absolute neutrophil count ≥ 1,000/mm\^3 (500/mm\^3 if there is lymphomatous involvement of the bone marrow)
* Platelet count ≥ 50,000/mm\^3

Hepatic

* Bilirubin ≤ 1.5 times upper limit of normal (ULN)
* AST or ALT ≤ 2.5 times ULN (4 times ULN if there is liver involvement)

Renal

* Creatinine ≤ 2 times ULN OR
* Creatinine clearance ≥ 50 mL/min

Cardiovascular

* No history of orthostatic hypotension
* No myocardial infarction, cerebrovascular accident, or transient ischemic attack within the past 3 months
* No New York Heart Association class III or IV congestive heart failure
* No unstable angina pectoris
* No cardiac arrhythmia
* No uncontrolled hypertension requiring manipulation of antihypertensive medications
* No evidence of any of the following by echocardiogram:

  * Acute ischemia
  * Significant conduction abnormality

    * Bifascicular block
    * 2\^nd- or 3\^rd-degree atrioventricular block

Other

* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* HIV negative
* No other immunodeficiency
* No known severe hypersensitivity reaction to agents containing Cremophor EL
* No ongoing or active infection
* Febrile episodes up to 38.5° Celsius allowed in the absence of infection
* No other concurrent uncontrolled illness that would preclude study participation
* No psychiatric illness or social situation that would preclude study compliance
* No preexisting grade II or greater sensory neuropathy

PRIOR CONCURRENT THERAPY:

Biologic therapy

* At least 3 months since prior monoclonal antibodies (unless there is clearly documented evidence of disease progression after therapy)
* At least 3 months since prior radioimmunotherapy
* No prior allogeneic bone marrow transplantation

Chemotherapy

* At least 4 weeks since prior cytotoxic chemotherapy (6 weeks for mitomycin, nitrosoureas, or carmustine) and recovered
* No more than 4 prior chemotherapy regimens (including high-dose chemotherapy \[HDC\] for patients with relapsed disease \> 100 days after completion of HDC)

  * Cytoreduction plus HDC is considered 1 chemotherapy regimen
* No other concurrent chemotherapy

Endocrine therapy

* At least 7 days since prior steroids

Radiotherapy

* More than 3 weeks since prior radiotherapy and recovered
* No concurrent radiotherapy

Surgery

* More than 4 weeks since prior major surgery

Other

* Use of antibiotics for marginal zone lymphoma does not count as a prior therapy
* No other concurrent investigational agents
* No other concurrent anticancer therapy