cyrilzakka/clinical-trials huggingface dataset:
Attitudes Towards Disability of Nursing and Physiotherapy Students

The general objective of this study is to know the attitude towards people with disability of Nursing and Physiotherapy students in the University of Cadiz. This is a descriptive, correlational, transversal and synchronous study.

Attitudes determine our behaviour to some extent. Health professionals should have a global perspective of disability. They must provide treatment to people with disability and care for them, but also should accept them with no judgements or discrimination. The general objective of this study is to know the attitude towards people with disability of Nursing and Physiotherapy students in the University of Cadiz. Method: This is a descriptive, correlational, transversal and synchronous study. A total of 200 students participate in the study (91 from the Bachelor's Degree in Nursing and 109 from the Bachelor's Degree in Physiotherapy). The 'Attitudes towards people with disability Scale' was used.

Eligibility Criteria:
Inclusion Criteria:

* Students from the Physiotherapy Bachelor´s Degree of the university of Cadiz
* Students from the Nursing Bachelor´s Degree of the university of Cadiz, Campus of Jerez de la Frontera and Cadiz

Exclusion Criteria:

* None
A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation

Hypoplastic left heart syndrome (HLHS) is a severe form of congenital heart disease that consists of multiple obstructions to flow through the left heart and aorta, as well as hypoplasia of the left ventricle. Most patients require a three-stage surgical protocol starting within days of birth. Stage I of this process is the Norwood reconstruction (within the first few days of life), Stage II (usually required within 3-8 months) involves creation of a direct connection between the patient's superior vena cava and the pulmonary arterial confluence (bidirectional Glenn anastomosis), and the last stage is creation of a Fontan circulation (typically within the first 2-4 years). This "single ventricle" approach requires the right ventricle to perform as the only circulatory pump for the entire body.

Our long-term goal is to develop regenerative strategies to strengthen and augment the right ventricular muscle of the single-ventricle heart following surgical palliation in HLHS patients. To determine the safety and feasibility of a cell-based therapeutic intervention at the Stage II surgery, we aim to document the natural history of post-surgical care in HLHS patients having undergone standard of care with protocol specific follow-up over the course of a 6-month period.

This prospective study will document the natural history in patients with HLHS after planned Stage II surgical palliation with a focus on cardiovascular parameters within 6 months following surgery in 10 patients.


Eligibility Criteria:
Inclusion Criteria:

* Individuals with HLHS having undergone Stage I surgical palliation and undergoing planned Stage II palliative Glenn surgery.
* Individuals up to 18 months of age are eligible if written informed consent can be obtained from both parents and/or legal guardians, unless one parent is not reasonably available.

Exclusion Criteria:

* Severe chronic diseases, extensive extra-cardiac syndromic features, or history of cancer

The following complications of congenital heart disease:

* Any condition requiring urgent, or unplanned procedure within 15 days prior to Stage II surgical repair.
* Severe pulmonary hypertension (reported in the medical record as \>70% systemic pressure).
* Other clinical concerns as documented by a site investigator that would predict (more likely to happen than not to happen) a risk of severe complications or very poor outcome during or after Stage II surgical repair.
Impact of Preoperative Hypocaloric Hyperproteinic Lipid Restricting Diet on Bariatric Surgery

Obesity is one of the greatest pandemics of the 21st century with 30 million new cases each year. In France each year, 60,000 bariatric surgery procedures are performed.

Many preoperative diets have been proposed in the literature with some studies giving positive results. But these diets are often strict and can have adverse effects on metabolism. Very few studies have described the PSMF diet. The hypothesis would be that this diet is associated with a reduction in liver volume with a reduction in steatosis.


Eligibility Criteria:
Inclusion criteria:

* Adult patient (≥18 years old)
* Man and woman
* Patient operated on at the HUS between 2010 and 2021 for bariatric surgery
* Patient not objecting to the reuse of their data for scientific research purposes.

Exclusion criteria:

- Patient who has expressed his opposition to the reuse of his data for scientific research purposes.
Evaluating Clonogenic Epithelial Cell Populations in Patients with Bronchiolitis Obliterans Syndrome

This study investigates a type of cell, called abnormal clonogenic epithelial cells, in patients with bronchiolitis obliterans syndrome who have had an donor stem cell transplant or a lung transplant. Learning more about clonogenic cells in these patients may help doctors to detect signs of bronchiolitis obliterans syndrome earlier in future patients.

PRIMARY OBJECTIVE:

I. To characterize epithelial cell phenotypes in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) and in lung transplant recipients at Houston Methodist who have bronchiolitis obliterans syndrome (BOS).

OUTLINE:

Patients undergo collection of blood samples and 3 brushings of the airway during standard of care (SOC) bronchoscopy. After the bronchoscopy, patients undergo 2 nasal brushings (swabs). Patients' medical records are also reviewed for data collection.

After completion of study, patients are followed for up to 1 year.

Eligibility Criteria:
Inclusion Criteria:

* Allo-HCT recipients undergoing a bronchoscopy at MDACC who consent to undergoing study airway brushings in addition to clinically indicated bronchoscopic procedures (e.g. bronchoalveolar lavage)

  * 5 patients with advanced BOS - forced expiratory volume in one second (FEV1) =\< 75% predicted and meeting other National Institutes of Health (NIH) criteria (FEV1/forced vital capacity \[FVC\] ratio 0.7, presence of air trapping or graft versus host disease \[GVHD\] of another organ)
  * 5 patient with early BOS - at least 10% decline in FEV1 from baseline values, with FEV1 \>= 75% predicted, and 1 high-risk feature:

    * Active systemic chronic GVHD with new early airflow obstruction OR
    * Respiratory viral infection in last three months with resolution of viral symptoms but new airflow obstruction
  * 3 patients with no pulmonary impairment (FEV1 within 5% of baseline values)
* Lung allograft recipients undergoing a bronchoscopy at Houston Methodist who consent to undergoing study airway brushing sin addition to clinically indicated bronchoscopy procedures

  * 5 patients with BOS Stage 2 or higher (\>= 35% decline in FEV1 from baseline values)
  * 5 patient with BOS Stage 0p or 1 (10-35% decline in FEV1 from baseline values)
  * 3 patients undergoing screening bronchoscopy without decline in FEV1
  * patients with undiagnosed lung cancer and chronic obstructive pulmonary disease diagnosed by pulmonary function testing (FEV1/FVC less than the lower limit of normal with \>20 pack-year history of smoking)

Exclusion Criteria:

* Bronchoscopy performed on emergency basis for life-threatening issues as opposed to routine diagnostic testing
* Patient unwilling to give consent for study airway brushings
Does Midazolam Cause Effective Anterograde Amnesia in Orthopedic Surgeries?

Spinal anesthesia is one of the commonest choices of anesthesia for infraumbilical surgeries.The use of sedation has markedly increased patients' comfort and acceptance towards spinal anesthesia. The aim of this study is to investigate visual, recall, auditory recall, and sedation scores among patients receiving Midazolam for sedation during spinal anesthesia in patients undergoing orthopedic surgeries.

Spinal anesthesia is one of the commonest choices of anesthesia for infraumbilical surgeries.The use of sedation has markedly increased patients' comfort and acceptance towards spinal anesthesia. The main goals of sedation for surgeries under spinal anesthesia are patient comfort, preservation of protective airway reflexes, and the help in the maintenance of hemodynamic stability during the surgical procedure. The aim of this study is to investigate visual, recall, auditory recall, and sedation scores among patients receiving Midazolam for sedation during spinal anesthesia in patients undergoing orthopedic surgeries.

Eligibility Criteria:
Inclusion Criteria:

* patients undergoing total knee or total hip replacement.
* ASA I, II, or III.
* patients undergoing spinal anesthesia.

Exclusion Criteria:

* patient refusal.
* \<24 hours sedative administration.
* patient with hearing impairment.
* neurological or memory disorder.
* abnormal kidney function tests.
* any contraindication for spinal anesthesia.
An Observational Study to Evaluate Cardiovascular Outcomes of T2DM PatientsTreated With Gemigliptin

The primary objective of the study is to investigate cardiovascular safety of gemigliptin by evaluating the time until patients report with major adverse cardiovascular events (MACE) in T2DM patients treated with gemigliptin.

Study patients will be followed up to 4 years until MACE occurrence or until the patient drops out of the study or completion of the study. The patient who switches to a non-gemigliptin treatment after initiating gemigliptin therapy will be followed until MACE occurrence or until the patient drops out of the study or completion of the study.

The secondary objectives of the study are to evaluate adverse events related as well as not-related to MACE in diabetic patients treated with gemigliptin.


Eligibility Criteria:
Inclusion Criteria:

* Female or male patients, who are ≥ 19 years, with diagnosis of T2DM
* Diabetic patients whose condition cannot be adequately controlled by on-going dietary and/or under antidibatetic treatment are decided to prescribe gemigliptin according to the physician's judgment
* Patients must be willing and able to provide written informed consent form to use of personal information as well as the guardian's contact information and the permission to contact with the guardian in case the patient cannot be contacted.

Exclusion Criteria:

* Patients with T1DM
* Patients who experienced an acute coronary syndrome (ST-elevation myocardial infarction and non- ST elevation myocardial infarction) or ischemic stroke within the last 3 months before enrolment OR patients who have been treated with dipeptidyl peptidase IV (DPP-4) inhibitors or glucagon-like peptide (GLP-1) analogues for 3 months before enrolment.
* Patients with a diagnosis of severe or end-stage heart failure (New York Heart Association class III or IV).
* Patients who are currently participating or plan to participate in any interventional clinical trial
* Patients who are not prescribed gemigliptin or with counterindications for gemigliptin
* Patients who are considered not fit for the study by physician
LT for Unresectable Colorectal Liver Metastasis

Unlike hepatocellular carcinoma, liver transplantation in patients with liver metastasis from colorectal cancer is limited in only few centers. Previously, it was not generally implemented due to lack of organs and high recurrence rates after transplantation. However, due to progressive development in treatments, good results such as increased survival rates can be expected even in liver transplant patients with liver metastasis from colorectal cancer, which is known to have poor prognosis. Therefore, the purpose of this study is to analyze the efficacy of liver transplantation as an alternative treatment for liver metastasis from colorectal cancer.

Surgical treatment offers a distinct survival benefit in liver metastasis of colorectal cancer (CRC LM). However, it has been estimated that only 40% of patients are candidates for curative liver resection. Liver transplantation can be considered as one of a treatment option, since all evident disease is removed during procedure. However, it is limited in only few centers due to lack of organs and high recurrence rates after transplantation.

Currently, with help of development in treatments, prognosis after LT in CRC LM is improving. Recent study of LT for CRC LM from Norway demonstrated a 5-year survival of 56%. In addition, cohort study and randomized controlled trials are ongoing in Germany and Canada. Therefore, it seems to be necessary to verify the effectiveness of liver transplantation for CRC LM and to verify it as an alternative treatment if there is no other treatment. The purpose of this study is to analyze the efficacy of liver transplantation as an alternative treatment for liver metastasis from colorectal cancer.

Potential participants will be evaluated for liver transplantation and must also have a willing, healthy living donor. Unresectable metastasis should be limited to the liver and stable without no other treatment such as immunotherapy, chemotherapy, surgical resection, and radiofrequency ablation. The suitability of liver transplantation will be evaluated through a multidisciplinary assessment immediately before transplantation. Those participants who undergo liver transplantation will be followed for survival, disease-free survival, and recurrence for 3 years.

Eligibility Criteria:
Inclusion Criteria:

* Proven colorectal cancer liver metastases without no other treatment (such as immunotherapy, chemotherapy, surgical resection, and radiofrequency ablation)
* Metastasis isolated to liver
* Patients selected as a liver transplant recipient at a multidisciplinary meeting
* Paitents with a willing, healthy living donor
* Willing and able to provide written informed consent

Exclusion Criteria:

* Pregnant women
* Known history of human immunodeficiency virus (HIV) infection
* Patients with active peptic ulcer within 2 weeks of transplantation
* Persistent colorectal cancer after colon resection
* Hemodynamically unstable prior to liver transplantation
* Progression of LM at any timepoint prior to transplant surgery (assessed in a multidisciplinary meeting)
Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy Hypoparathyroidism

This study aims to compare two different protocols commonly used in the management of post thyroidectomy hypoparathyroidism : PTH based calcium repletion and empiric repletion. The investigators aim to compare the quality of life associated with these two protocols in a randomized trial.

Enrolled patients will be randomized in two treatment groups. In group 1, all patients will receive calcium carbonate and calcitriol in the post-operative period, with standardized weaning. In group 2, patients will be prescribed calcium carbonate and calcitriol only if their post-operative PTH dosage is 25% or less of the pre-operative dosage, or if post-operative PTH is inferior to 15.

The Short-Form 36 (SF-36) questionnaire (French canadian version) will be used to assess quality of life pre-operatively and at post-op week 1 and 4. Symptoms of hypocalcemia and adverse effects of calcium carbonate and calcitriol will be monitored at week 1 and 4.

Eligibility Criteria:
Inclusion Criteria:

* Total thyroidectomy or completion hemithyroidectomy

Exclusion Criteria:

* Need for neck dissection
* Unable to fill in questionnaires (intellectual deficit, severe psychiatric disorder, illiterate, does not speak French or English)
Characterization of Variable MARrcha's Diary Variables as a Useful Measure

Validate a simple clinical tool to evaluate physical activity (the question "How many minutes does it walk per day?" Or equivalent), compared to the rest of the collected physical activity data (PROactive questionnaire and objective physical activity data by means of an accelerometer record) in patients with COPD.

Observational, national and multicenter epidemiological study in adult patients with COPD that will take place in the consultations of specialists in pneumology under conditions of usual clinical practice and that will be developed in two visits per patient.

Eligibility Criteria:
Inclusion Criteria:

Adult patients, ≥ 40 years.

* Patients diagnosed with COPD according to the GOLD criteria: FEV1 / FVC postbronchodilator \<0.70 in a spirometry performed in the last 12 months.
* Smokers or ex-smokers of ≥10 pack-years.
* Patients with a minimum age in the diagnosis of COPD of at least 6 months.
* Patients who accept their participation in the study and who have given their informed consent (IC) in writing to participate in it.

Exclusion Criteria:

* Patients whose clinical history data are not available.
* Patients unable to understand the study questionnaires.
* Patients with physical limitation (not caused by the respiratory disease, eg disability, orthopedic limitation, etc.) and / or psychic that prevents the proper conduct of the study.
* Patients who present a moderate or severe exacerbation of COPD in the month prior to inclusion.
* Patients with other chronic respiratory diseases other than COPD (such as cystic fibrosis, bronchiectasis of origin other than COPD, neoplasia, pneumonia).
* Patients with serious cardiovascular or neurological diseases.
* Hospital admission for any reason in the month prior to inclusion.
Linagliptin Response to OGTT in Prediabetes and Type 2 Diabetes Mellitus

There are studies that suggest glycemic response to incretin-based therapies differs between Asians and Caucasians, whereby Asians have better response compared to Caucasians. Hence, the therapeutic response could also be augmented by difference in incretin system among various ethnicities. This study is carried out to study the effect of dipeptidyl-peptidase IV (DPPIV) inhibitors in prediabetes and T2DM patients who have different levels of GLP-1 and to determine the effect on glycemic profiles, insulin resistance/sensitivity, beta-cell functon.

A 12-week, open-label, single treatment study using linagliptin is conducted in 28 prediabetes and 22 T2DM subjects who are divided into low and high fasting GLP-1 groups. Prediabetes are recruited from OGTT screening. Type 2 diabetes patients are recruited from specialised diabetes clinic and routine follow-up. A 75-g oral glucose tolerance test (OGTT) is performed at week 0 and 12. Venous blood samples were drawn at times 0 (before initiation of OGTT), 30, 60, 90, 120 min from the indwelling catheter for measurement of glucose and insulin.All prediabetes and T2DM subjects receive Linagliptin 5mg once daily for a duration of 12 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Prediabetes diagnosed from OGTT and T2DM subjects
* HbA1c \> 6.5% and \<10%
* Subjects not receiving any glucose-lowering medication or just receiving metformin and/or sulphonylureas and/or alpha-glucosidase inhibitors on stable dose for at least 3 months.
* Subjects who are willing to participate and sign the informed consent form

Exclusion Criteria:

* Subjects with ketoacidosis or lactic acidosis, overt diabetes, another disease causing secondary glucose intolerance, congestive heart failure (New York Heart Association Class III or IV), myocardial infarction, stroke or ischemic attacks in past 6 months, uncontrolled severe hypertension, active liver conditions such as cirrhosis or hepatitis \[elevation in liver enzymes to higher activities than double the respective normal value\], moderate to severe renal insufficiency, pregnancy, breast-feeding
* Patients receiving insulin, GLP-1 receptor agonists, dipeptidyl peptidase IV inhibitors or glucose-lowering medications other than metformin /sulphonylureas /alpha-glucosidase inhibitors as treatment.
* Subjects with uncontrolled blood glucose HbA1c\>10%
* Subjects who plan to move out of state / country
Efficiency of Abdominal Corset and Core Stabilization Exercises in the Treatment of Postpartum Diastasis Recti Abdominis

Participants will be randomly divided into three groups as core stabilization group, combination of core stabilization and corset group and only corset group.

30 volunteer women who were diagnosed with diastasis recti abdominis by an obstetrician in Çamlıca Medipol Hospital, aged between 18-35 and met the inclusion criteria will be included in the study. Participants will be randomly divided into three groups. Participants in the first group will do core stabilization exercises for the transversus abdominis muscle 3 days a week for 8 weeks with 10 repetitions. In the second group, in addition to the first group, core stabilization exercises will be performed by wearing an abdominal corset. Participants included in the third group will be asked to wear only this corset all day (except for the bathroom) for 8 weeks. Anthropometric measurements, ultrasonographic evaluation, Visual Analogue Scale (VAS), Edinburgh Postnatal Depression Scale, abdominal muscle strength and endurance, Oswestry Disability Index will be evaluated as pretest and posttest.

Eligibility Criteria:
Inclusion Criteria:

* Being between the ages of 20-35,
* Having a normal birth,
* Being at least 6 weeks postpartum when DRA is diagnosed,
* Absence of any musculoskeletal or neurological problems,
* Volunteering to do the exercises

Exclusion Criteria:

* Cesarean delivery,
* Edinburgh Postnatal Depression questionnaire result being \>13,
* Having a systemic disorder
The Value of Serum MicroRNA-21-5p and LncRNAgadd7 Expression Levels in Predicting the Severity and Prognosis of ARDS ( Acute Respiratory Distress Syndrome )

By measuring the expression levels of MicroRNA-21-5p (miR-21-5p) and LncRNAgadd7 in the peripheral blood of ARDS patients, the study aims to explore the correlation between these levels and the severity and prognosis of ARDS.


Eligibility Criteria:
Inclusion Criteria:

1. Age ≥ 18 years;
2. Meets the Berlin Criteria for ARDS;
3. Diagnosed with ARDS within 48 hours;
4. Signed informed consent.

Exclusion Criteria:

1. Immunosuppressed patients: including those on immunosuppressive drugs, history of stem cell transplantation, etc.;
2. Patients with malignant tumors;
3. Pregnant women;
4. Patients discharged from the ICU within 48 hours;
5. History of chronic lung diseases.
Acute Effects of Fruit Juices Consumption on Postprandial Glycemic Responses and Satiety

This study investigated the acute effects of two fruit juices on postprandial glycemic responses and satiety in healthy individuals

This study aimed to 1. Determine the glycemic index and glycemic load of two types of fruit juices (orange juice and mixed fruit juice consisted of apple, orange, grape, and pomegranate) and 2. Investigate the effects of these two fruit juices on postprandial glycemic responses and satiety in healthy individuals

Eligibility Criteria:
Inclusion Criteria:

* healthy
* non-smoking
* non-diabetic and normotensive men and women
* body mass index between 18.5 and 25 kg/m2

Exclusion Criteria:

* severe chronic disease (e.g. cardiovascular diseases, diabetes mellitus, kidney or liver conditions, endocrine conditions)
* gastrointestinal disorders
* pregnancy
* lactation
* competitive sports
* alcohol abuse
* drug dependency