cyrilzakka/clinical-trials huggingface dataset:
The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease

Objectives: The purpose of this study was to investigate the effects of high-frequency repetitive Transcranial Magnetic Stimulation (rTMS) in Alzheimer's Disease (AD).

Methods: Twenty-seven AD patients aged ≥60 years were included in the study and divided into 3 groups (rTMS, Aerobic Exercise (AE) and control). All groups received pharmacological treatment. rTMS group (n=10) received 20 Hz rTMS treatment on bilateral dorsolateral prefrontal cortex, 5 days a week over 2 weeks, and AE group (n=10) received the moderate-intensity aerobic exercise for 50 min sessions, 5 days a week over 2 weeks. Control group (n=10) was only treated pharmacologically. Neuropsychiatric and behavioral status, cognition, balance, functional mobility, and quality of life, and functional brain changes were evaluated before and after the treatment.


Eligibility Criteria:
Inclusion Criteria:

* having clinical AD diagnosis according to the NINCDS-ADRDA (National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association) criteria
* being 60 years and older
* having Clinical Dementia Rating Scale (CDR) scores 1 or 2
* living independently

Exclusion Criteria:

* not being able to walk independently,
* having physical disabilities,
* having a history of alcohol / substance abuse,
* having head trauma
* having epileptic seizures
Accelerated iTBS for Depression and Suicidality

The overall objective of this current study is to evaluate the feasibility, safety, and tolerability of "high dose" aiTBS in psychiatric inpatient and outpatients with treatment-refractory unipolar, non-psychotic major depressive disorder, using patients receiving ECT as an active comparator. Developing a better understanding of the feasibility and tolerability of adapting this treatment to an acutely ill patient population could lead to huge breakthroughs for clinician decision-making and for the further optimization of brain stimulation depression protocols. The results of this study can help guide future confirmatory efficacy trials of high-dose aiTBS by providing a better understanding of how feasibility, safety and tolerability compare to ECT, as well as unforeseen challenges of its use.


Eligibility Criteria:
Inclusion Criteria:

* • Ability to provide informed consent

  * Availability for the duration of the study and willingness to comply with all study procedures
  * Age 18 to 90
  * Diagnosis of major depressive disorder by DSM-5 criteria
  * Depressive symptoms are thought to be caused primarily by a major depressive episode and not by some other neurologic or psychiatric illness
  * Failure of or intolerance to at least 2 antidepressant treatments of different therapeutic classes (can include psychotherapy trial or neurostimulation trial)
  * Meets criteria for clinical eligibility for ECT treatment, including optimization of any medical conditions and completion of any medical testing or clearance as clinically indicated
  * Able to consent voluntarily to treatment
  * Score of at least 2 on the MADRS item 10
  * Ability to sit or lie down for an extended period of time and willingness to adhere to the theta burst stimulation protocol

Exclusion Criteria:

* • Presence of implanted ferromagnetic devices or materials, including cardiac pacemaker, cochlear implant, deep brain stimulation device, vagus nerve stimulation device, shrapnel, facial or scalp piercings that cannot be removed, or metallic face or head tattoos

  * Pregnancy or lactation
  * Previous bad reaction or intolerance to transcranial magnetic stimulation
  * Febrile illness within 1 week
  * Treatment with another investigational drug or other intervention within 30 days
  * Recent substance abuse or use disorder within the past 6 months, excluding tobacco or infrequent cannabis use
  * History of epilepsy or seizure disorder
  * History of penetrating traumatic brain injury, multiple sclerosis, or history of brain surgery or intracranial hemorrhage
  * Primary psychiatric or medical/neurologic illness other than MDD that is more likely to account for depressive symptoms, including severe personality disorder or psychotic illness
  * Severe or moderate intellectual disability
  * Major neurocognitive disorder
  * Involuntary commitment or petition filed for involuntary ECT treatment
Comparative Effects of Visual and Pressure Biofeedback in Symptomatic Forward Head Posture.

This study aims to determined the comparative effect of visual and pressure biofeedback on Pain,Disability and Range of Motion in young and middle aged adults diagnosed with forward head posture.

Forward head posture describes the shifting of the head forward with the chin poking out. It is caused by increased flexion of the lower cervical spine and upper thoracic.

Forward head posture is the most frequently observed postural deviations and is said to be associated with shortening of posterior cervical extensors and weakening of the anterior deep cervical flexors. In this randomized control trial participants showing forward head posture will be randomly assigned into two intervention groups. 28 subjects were divided equally into two groups 14 each containing both genders. Group A (Experimental group) will be given isometric strengthening and stretching training guided pressure biofeedback.

Group B (Experimental group) will be given isometric strengthening and stretching training of deep cervical flexor (DCF) muscle guided through visual biofeedback .

Each participant will be receive a total of twelve treatment sessions over a four-week period. The efficacy of the interventions will be assessed at the beginning (first session) and conclusion (last session) of the treatment period. The assessment will encompass various outcome measures. Pain intensity will be evaluated using the Numeric Pain Rating Scale (NPRS), while disability levels will be measured using the Neck Disability Index (NDI). The cervical active range of motions (CAROMs) will be assessed by goniometry. Finally, the visual feedback referred as indicator of measuring forward head posture by evaluating these outcome measures insights will be gained into the impact of the interventions on the participants' symptoms and postural alignment through light. The randomized design of the trial provide valuable information to healthcare professionals on how to manage symptomatic forward head posture and may contribute to the development of future research in this area.

Eligibility Criteria:
Inclusion Criteria:

1. Participants would be complaining of neck pain as a primary complain and age of 20- 35 year was recruited in the study .

2 . Male and female both gender are included in the study.

3. patient with Craniovertebral angle (CVA)\<53 degree were included in the study .

4. Score more than 3 on NPRS and more than 10 on NDI.

Exclusion Criteria:

Participant failing to fall in this category would be excluded of the study.

1. Neurogenic findings like cervical trauma, myopathy, vestibular pathology, dizziness, visual problem, spinal Fracture, dislocation and hypertension will not include in the study.
2. History of sever metabolic diseases.
3. History of recurrent surgery in upper thoracic and lumber vertebrae
4. History of recent fractures in shoulder and neck region.
5. History of tumor. -
Combined Lumbosacral Nerve Block Versus Spinal Anesthesia for Cognitive Function After Hip Prothesis

Hip fracture is a potentially devastating event, and serious surgical and medical complications occur frequently especially for elderly patients. Delirium is one of the common complications after hip surgery. Controversy exists regarding the possible impact of type of anesthesia (nerve block versus spinal) upon acute and long-term cognitive decline.

The primary objective is to assess the association between type of anesthesia (nerve block vs. spinal anesthesia) and risk of cognitive decline (CD). The secondary objective is to compare intra-operative hemodynamic changes, use of vasopressor drugs, and use of post-operative analgesics with respect to the type of anesthesia.

Prospective, double blind randomized clinical trial of hip fracture patients who will be assessed for CD pre- and postoperatively, using the Mini Mental State Examination (MMSE). The presence of CD will be determined at follow-up evaluation up to three months after surgery.

Prospective, double blind randomized clinical trial of hip fracture patients who will be assessed for CD pre- and postoperatively, using the Mini Mental State Examination (MMSE). The presence of CD will be determined at follow-up evaluation up to three months after surgery. Patients undergoing hip surgery will be randomized into two groups. Group 1 will receive unilateral lumbosacral nerve block (sciatic nerve block and paravertebral block at levels L3-L4 and L4-L5) as well as placebo injection (1 ml normal saline) at the spinal anesthesia level (L3-L4 or L4-L5). The sciatic nerve will be injected by 20 ml of the anesthetic mixture whereas levels L3-L4 and L4-L5 will be injected by a total of 20 ml of the anesthetic mixture without exceeding the maximum injected volume of 1 ml/kg. Group 2 will receive spinal anesthesia (3 ml of 0.5% bupivacaine) in addition to placebo injection at the sciatic, L3-L4 and L4-L5 levels.

Eligibility Criteria:
Inclusion Criteria:

* Admitted with a hip fracture (femoral neck, trochanteric or sub-trochanteric)
* 40 kg in weight and higher

Exclusion Criteria:

Patients who are:

* Uncooperative
* Considered as moribund by the orthopedic surgeon at admission
* Alzheimer
* Severe cognitive impairment (MMSE\<18)
* Absolute contraindication for spinal anesthesia (assessed preoperatively)
* Allergy to local anesthesia
Choice of Modality of Follow up for Medication Abortion

This study will assess the impact of providing medication abortion-seeking clients a choice for follow-up in practice. Clients presenting at or less than 63 days pregnant (based on last menstrual period) at the study site for first trimester medication abortion will be invited to participate. We hypothesize that providing clients with flexible follow-up options will improve follow-up rates.

This study is not to assess efficacy or safety of follow-up methods--that has been well established in practice and research. This is to assess choice of follow-up.


Eligibility Criteria:
Inclusion Criteria:

* Eligible for medication abortion \<63 days gestational age
* In general good health
* English or Spanish speaking competency
* Willing and able to sign consent forms

Exclusion Criteria:

* Clients less than 18 years of age.
* Any client not meeting the inclusion criteria listed above will be excluded from participating in the trial.
Clinical Assessment of Bifluorid 10 vs Varnish Fluoride on The Exposed Hypersensitive Cervical Dentin in Adult Patient

Aim of the study will be conducted to compare the efficacy of bifluoride (NaF and CaF) versus conventional fluoride varnish (Sodium Flouride) in the management of hypersensitivity of exposed cervical area in adult patients over 2 month


Eligibility Criteria:
Inclusion Criteria:

* Healthy patient with free medical history.
* Age range 18-60 years old.
* Good oral hygiene
* Patients suffering from pain due to dentin hypersensitivity.
* Patient with sound first molar .

Exclusion Criteria:

* Patients using desensitizing agents, receiving periodontal treatment or had received nonsurgical periodontal treatment in the last three months.
* Patient wearing orthodontic appliance.
* Patient with teeth having a painful condition involving the pulp and periapical region.
* Patients who had allergy to materials will be used in the study.
* Pregnancy.
* Patient who does not consent to participation.
* Patient who does not attend to the follow up.
* A patient who has a carious first molar.
Abdominal Weight Training Assisted by Cough Assist Machine on Lung Function

The patients with prolonged mechanical ventilation (PMV) have the risk of ineffective coughing and infection due to diaphragm weakness, making it more difficult to wean. This study aimed to explore the intervention of abdominal weight training (AWT) with/ without cough machine (CM) on lung function, respiratory muscle strength and cough ability in these patients.

Methods 40 patients with PMV were randomly assigned to three groups: AWT group (n=12), AWT+CM group (n=14) and control group (n=14). The effectiveness on pulmonary function, respiratory muscle strength and cough ability were compared among these three groups.

Eligibility Criteria:
Inclusion Criteria:

* (1) Invasive ventilator users,
* (2) Hemodynamically stable,
* (3) Intubated endotracheal tube or tracheotomy tube,
* (4) Clearly conscious and cooperative,
* (5) Vital capacity (VC) \<10ml/kg

Exclusion Criteria:

* (1) Unconscious or unwilling to sign the informed consent form,
* (2) No spontaneous breathing,
* (3) Active bleeding with unstable hemodynamics,
* (4) Acute infection symptoms,
* (5) Abdominal distension, digestion problems (including nausea and vomiting),
* (6) Severe heart failure (ejection fraction ≤ 30%),
* (7) Unhealed wounds in the chest and abdomen,
* (8) Bullous emphysema,
* (9) Sensitive pneumothorax or mediastinal pneumothorax,
* (10) Recent history of traumatic stress,
* (11) Acute head and neck injury (unless the injury site is immobilized)
A Study of ONO-7428 in Participants With Unresectable Advanced or Recurrent Solid Tumors

This study is to evaluate the tolerability and safety of ONO-7428 in participants with unresectable advanced or recurrent solid tumors.


Eligibility Criteria:
Inclusion Criteria:

1. Participants with histologically or cytologically confirmed unresectable advanced or recurrent solid tumors.

   \[Backfill cohort only\] Participants with histologically or cytologically confirmed Stage IIIB, IIIC, IV, or recurrent NSCLC according to UICC-TNM classification.
2. Participants who are refractory or intolerant to standard therapy.
3. Participants with a tumor type for which anti-PD-(L)1 antibodies have been approved and who have previously treated with anti-PD-(L)1 antibody containing regimen.
4. Participants with Eastern Cooperative Oncology Group Performance Status 0 or 1.
5. Participants with tumor tissue samples available for biomarker testing.

Exclusion Criteria:

1. Participants with a complication or history of severe hypersensitivity to any other antibody drugs.
2. Participants with concurrent autoimmune disease or a history of chronic or recurrent autoimmune disease
3. Participants with severe peritoneal dissemination.
4. Participants with pericardial fluid, pleural effusion, or ascites requiring treatment.
5. Participants with uncontrolled tumor-related pain.
6. Participants with active or history of interstitial lung disease or pulmonary fibrosis.
Impact of a Collaborative Program of Physical Activity of Newly-diagnosed Cancer Patients

During the last twenty years, the cancer overall incidence has been increasing in europe and developed countries, while diagnostic and therapeutic progress have contributes to a reduction in mortality. Currently, almost 4 million people are treated or followed for cancer in France. The physical, psychological and social after-effects are significant.

Adaptated physical activity plays an important role in the rehabilitation process. Overall, meta-analyses carried-out with most frequent cancers demonstrate that physical activity practiced would allow an improvement in quality of life, tolerance to anticancer treatments and survival.

This is a multicenter, two-arm parallel-group randomizes (in a 1:1 ratio), open-label, controlled intervention clinical trial of the comparison of long term adherence to physical activity between an adaptative, customized and collaborative exercise program and standard exercise prescription in patients with newly diagnosed cancer.

Eligibility Criteria:
Inclusion Criteria:

* newly-diagnosed cancer patient
* able to start a program of physical activity within the first year follow diagnosis
* performance status between 0 to 2

Exclusion Criteria:

* uncontrolled cardiovascular disease
* peripheral neuropathy grade 3-4 with risk of falling
* bone metastasis with risk of bone fracture
* platelets \<100X109/L
* hemoglobin \<8g/dL
* patient under legal protection
Analgesic Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Posterior Transversus Abdominis Plane Block in Patients Undergoing Open Nephrectomy

Renal cell carcinoma (RCC) accounts for 2-3% of all cancers and is a common malignancy of the genitourinary tract. Open nephrectomy, performed through midline, subcostal, or flank incisions, remains a standard treatment but often results in significant postoperative pain, leading to respiratory muscle dysfunction, increased pulmonary complications, and prolonged hospital stays.

Acute surgical pain arises from inflammatory responses, activation of spinal pain pathways, and muscle spasms. While postoperative pain typically improves during recovery, some patients develop chronic postsurgical pain (CPSP), lasting at least two months postoperatively.

Opioids and epidural analgesia are commonly used for pain control, but their side effects and invasiveness necessitate safer, effective alternatives. Ultrasound (US)-guided peripheral nerve and field blocks have become integral to multimodal analgesia. One such technique, the \*\*external oblique intercostal plane block (EOIPB)\*\*, was introduced as a modification of fascial plane blocks, targeting anterior and lateral cutaneous nerves (T6-T10). EOIPB offers advantages over quadratus lumborum block (QLB) and erector spinae plane block (ESPB) by being performed in the supine position and providing superior midline analgesia compared to serratus intercostal plane block (SIPB).

Similarly, the transversus abdominis plane (TAP) block, particularly the posterior approach, delivers analgesia from T7 to T12 by anesthetizing anterior and lateral cutaneous nerve branches. While case series suggest EOIPB may be effective for post-nephrectomy pain, comparative studies between EOIPB and posterior TAP block in open nephrectomy:

Aim of the Study:

To evaluate the postoperative analgesic effects of posterior transversus abdominis plane (TAP) block and external oblique intercostal plane block (EOIPB) in patients undergoing open nephrectomy under general anesthesia.


Eligibility Criteria:
Inclusion Criteria:

* Patients whom diagnosed as having renal carcinoma and scheduled for open nephrectomy under general anesthesia.
* ASA class II- III.
* Age ≥ 18 and ≤ 65 years.
* Body mass index (BMI) less than 40kg/m2.

Exclusion Criteria:

* 1. Patient refusal. 2. Hepatic and renal insufficiency. 3. Unstable cardiovascular or pulmonary disease. 4. History of psychiatric and cognitive disorders. 5. Patients with known sensitivity or contraindications to the drug used. 6. Patients on regular opioid consumption.
Left Atrial Appendage (LAA) Occluders After Catheter Ablation of Atrial Fibrillation

The primary objective of this study is to assess combined end point (All stroke, Systemic embolism, Cardiovascular death) between two groups.


Eligibility Criteria:
Inclusion Criteria:

* Patient has paroxysmal, persistent or permanent non-valvular atrial fibrillation (AF)
* Eligible for long term warfarin
* CHADS score \>= 1 (congestive heart failure \[CHF\], history of high blood pressure, 75 years of age or older, diabetes, prior stroke or transient ischemic attack \[TIA\])

Exclusion Criteria:

* Contraindicated for warfarin
* Contraindicated for aspirin or clopidogrel (Plavix)
* CHF Class 4
* Implanted mechanical valve
* Atrial septal or Patent Foramen Ovale (PFO) device
* Platelets \< 100,000 or hemoglobin \< 10
* Left ventricular ejection fraction (LVEF) \< 30%
Mitigating Cardiovascular Disease Risk Among Rural Diabetics

The study explored the effects of the cardiovascular disease risk reduction intervention on diabetes fatalism, self-care activities, social support, knowledge, perceived self-managment among a rural population.

An experimental pretest-posttest control group design was used to assess the effects of a diabetes health promotion intervention among participants recruited from rural churches located in the southern United States. The intervention, called Project Power, is a culturally relevant, church-based diabetes education program that was developed by the American Diabetes Association (ADA). Participating churches were randomized to experimental and control groups using random numbers tables having numerical parity no greater than 2. Since an individual church is the unit of randomization, all of the participants in that church received the same treatment condition. Churches randomized to the intervention group received the health promotion program, and those designated to the control group received an educational brochure. Recruitment, data collection and intervention delivery, for the intervention group, occurred on the church grounds.

Eligibility Criteria:
Inclusion Criteria:

* Self-identified African Americans aged 22 years or older, who have been diagnosed with Diabetes Mellitus, Type 1 or 2

Exclusion Criteria:

* Other than African American, younger than 22 years of age
Use of Vein Viewer for Insertion of Peripheral Venous Cannula in Pediatric Patients With Difficult Intravenous Access

The primary purpose of this prospective, randomized trial is successful intravenous (IV) cannulation on first attempt with the use of either the Vein Viewer (VV) or standard cannulation method. The secondary purpose is to find out if there is a difference in the total time to successful cannulation.

A single initial data page will be filled out by one of the study team members present with the IV Team at the time of the cannulation. The data from these forms will be entered by the investigator or research assistant into a database maintained only for this study. There will be two groups in this randomized study. One group will receive IV cannulation with the VV and the second group will receive standard cannulation without the VV. The chance of receiving either treatment is based on randomly generated computer codes, unknown by the IV team. We want to evaluate successful IV cannulation on first attempt as well as the time taken for cannulation. All documents will be de-identified of data that contains HIPAA protected health information (PHI) at the end of the study. We estimate approximate enrollment to be 790 children. The study is expected to last 12 months and will only be conducted at Children's Medical Center Dallas.

Eligibility Criteria:
Inclusion Criteria:

* Patients age 0-18 requiring IV cannula (ASA 1-4) with a modified DIVA score ≥ 2 at the time of assessment

Exclusion Criteria:

* Patients with visible veins will be excluded from the study as well as patients with known difficult IV access which are scheduled for PICC line placement.