cyrilzakka/clinical-trials huggingface dataset:
Risk Factors Related to Postoperative Acute Kidney Injury in Elderly Patients Undergoing Joint Replacement

Total hip arthroplasty refers to the replacement of the femoral head and acetabulum damaged by disease or trauma with an artificial hip joint, thereby restoring joint activity and original function. Acute kidney injury is a common complication after total hip arthroplasty. Previous studies have shown that the incidence of acute kidney injury after hip replacement is as high as 21.9%. Acute kidney injury has become a global safety issue, and the occurrence of acute kidney injury can lead to an increase in hospital stay, medical costs and increased risk of death.There is currently no global survey of the incidence of AKI, and only a number of studies have been conducted on specific patient groups (eg, inpatients, intensive care units \[ICU\] patients or children) due to differences in study design and definition of acute kidney injury.

The incidence and prevalence of different studies vary widely, ranging from 0.32% to 44.30%. There are few studies on the risk factors associated with acute kidney injury after total hip arthroplasty, and early acute kidney injury is often overlooked due to the limitations of the current KDIGO-based diagnostic method. Therefore, it is particularly important for clinicians to understand the risk factors for postoperative acute kidney injury .

Eligibility Criteria:
Inclusion Criteria:

* Patients age 65 or older
* One-sided joint replacement;
* ASA score grade I-III

Exclusion Criteria:

* Emergency surgery patients;
* Patients with severe liver and kidney dysfunction;
* Missing related data;
* Serious systemic diseases before surgery;
Efficacy of Nebulized Lidocaine, Salbutamol, and Beclomethasone Plus Salbutamol in the Covid-19 Patients With ARDS on Non-invasive Ventilation; Randomized Control Trial

The COVID-19, a pandemic as declare by WHO1, has a devastating impact on health and economic worldwide2. Literature suggests that acute respiratory distress syndrome (ARDS) develops over 20% of the infected individuals with Coivd-pneumonia3 along with other symptoms like fever followed by cough and dyspnea as well as chest pain in severe cases4. The current preventative strategies are non-specific10, and current interventions are predominantly supportive1. Recently, some studies have demonstrated anti-inflammatory actions for local anesthetics including lidocaine.


Eligibility Criteria:
Inclusion Criteria:

* Covid-19 positive
* Moderate to severe ARDS

Exclusion Criteria:

* patients with COPD or taking bronchodilators and steroids for chronic respiratory illnesses
Clinical Evaluation of the Mandibular Mini-Implant Overdenture

Stabilization of existing full lower dentures by means of mini-dental implants (MDI). To test whether 4 mini-implants placed at the front of the lower jaw can stabilize an immediately-modified existing lower denture.

To test whether the percentage of case successes of these lower dentures supported by 4 MDIs is equal to or greater than 95% at 1 year. Success is defined as a denture supported by implants that is functioning in the way it was intended.

Eligibility Criteria:
Inclusion Criteria:

* Completely edentulous with last tooth extraction 2 years ago or longer.
* Patients requesting implant stabilization of existing lower conventional denture.
* Adequate space in anterior mandible for placement of 4 MDI implants.
* Able to maintain adequate oral hygiene and keep dentures clean.
* Healthy enough to have minor surgical procedures.
* Have adequate understanding of written and spoken English or French.
* Capable of providing written informed consent.

Exclusion Criteria:

* Not enough room in mandibular bone for implant height.
* Has acute or chronic symptoms of parafunctional disorders.
* History of radiotherapy to orofacial region.
* Are or have been taking bisphosphonate IV or other medications (to be evaluated by the researcher).
* Health conditions that may jeopardize treatment (to be evaluated by the researcher).
* Unable or unwilling to return for evaluations or study recalls.
Hyperbaric on Pulmonary Functions in Post Covid -19 Patients.

Purpose of the study is to investigate the effect of hyperbaric oxygen on FVC, FEV1 and on oxygen saturation in post-COVID-19 patients, The effect of breathing exercises in form of diaphragmatic breathing exercise and pursed lip breathing with traditional medical treatment in form of (vitamin D, vitamin C and anticoagulation drugs on FVC, FEV1 and on oxygen saturation in post-COVID-19 patients.and the difference between the effect of hyperbaric and breathing exercises in form of diaphragmatic breathing exercise and pursed lip breathing with traditional medical treatment in form of (vitamin D, vitamin C and anticoagulation drugs on FVC, FEV1 and on oxygen saturation in post-COVID-19 patients

Seventy two covid-19 patients from both genders ranged in age chronology from twenty one to sixty six years will be conducted to participate in this study .Selection of the study sample and evaluate of pulmonary functions improvement as well as hyperbaric oxygen therapy will be conducted at Agriculture Hospital in El Mansoura town.

The study sample will be divided randomly into two equal groups of(A\&B).All patients participated in the current study will receive breathing excesses in form of Diaphragmatic breathing exercise and Pursed lip breathing with traditional medical treatment in form of (vitamin D, vitamin C and Anticoagulation drugs ,group A will receive 60 minutes of HBOT(100%oxygen at 2 ATA with five minutes air breaks every twenty minutes daily in morning for three weeks then take period time of rest about 30 minutes before starting breathing exercise.

The Body mass index (BMI) of each participated patient will be determined by measuring weight/ Kg and height/ m2 using Electronic weight and height scale to include BMI 25.0-29.9 Kg/ . Also using Digital spirometer SMP 21/01 RD (Russian) for measuring of FVC parameters , to be less than 80% ,FEV1 to be less than 80% and Pulse Oximeter for measuring Oxygen saturation to range from 90%to 95% assessment will be done before and after treatment.

The obtained results of this study will measure Forced vital capacity (FVC), Forced expiratory volume (FEV1) and oxygen saturation to determine the significant improvement of participated patients.


Eligibility Criteria:
Inclusion Criteria

* 1. post Covid -19 patients (2weeks after recovery).

  2.post Covid -19 patients with deficiency in forced vital capacity (less than 80%) forced expiratory volume (less than 80%) lower oxygen saturation (90%-95%).

  3.age (21-66)years old.

  4.both gender.

  5.BMI 25.0-29.9.

Exclusion Criteria:

1. COPD or other respiratory diseases.
2. Neurological disease.
3. mental illness.
4. Critically ill patients with intubation.
5. smokers.
6. Inner ear diseases.
7. pregnancy.
Study of Two Formulations of GSK Biologicals' Varicella Vaccine

The aim of this study is to evaluate a modified formulation of GSK Biologicals' live attenuated varicella vaccine. In vivo pre-clinical data show this change has no negative impact on vaccine safety. This present study is undertaken to rule out any negative impact on the immunogenicity and safety of GSK Biologicals' live attenuated varicella virus vaccine.


Eligibility Criteria:
Inclusion Criteria:

* Subjects who the investigator believes that their parents/guardians can and will comply with the requirements of the protocol (e.g. completion of the diary cards, return for follow-up visits) should be enrolled in the study.
* A male or female between, and including, 11 and 21 months of age at the time of the first vaccination.
* Written informed consent obtained from the parent or guardian of the subject.
* Healthy subjects as established by medical history and clinical examination before entering into the study.

Exclusion Criteria:

* Use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned use during the study period.
* Chronic administration of immunosuppressants or other immune-modifying drugs within six months prior to the first vaccine dose.
* Planned administration/ administration of a vaccine not foreseen by the study protocol within 30 days prior to the first study vaccine dose until 42 days after second study vaccine dose with the exception of oral polio vaccine (OPV) which can be given at any time and routine inactivated vaccines which can be administered up to eight days before each study vaccine dose.
* Previous vaccination against varicella.
* Known history of clinical varicella.
* Known exposure to varicella within 30 days prior to study start.
* Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination.
* A family history of congenital or hereditary immunodeficiency.
* History of allergic disease or reactions likely to be exacerbated by any component of the vaccine(s), including systemic hypersensitivity to neomycin.
* Major congenital defects or serious chronic illness.
* Acute disease at the time of enrolment. All vaccines can be administered to persons with a minor illness.
* Axillary temperature ≥ 37.5°C / Rectal temperature ≥ 38°C.
* Residence in the same household as a high risk person e.g.: new-born infants (0-4 weeks of age), pregnant women who have a negative history of chickenpox, persons with known immunodeficiency
'My Life is Music' Group Therapy Model - a Feasibility Study for Adolescents with Persistent Pain

The aim of this multi-method feasibility study is to learn if a group therapy model using music can be applied in the treatment of adolescents with persistent pain. We are interested how the patients find participating in the group therapy as part of their rehabilitation and if the patient´s experience of music changes during the therapy process.


Eligibility Criteria:
Inclusion Criteria:

* persistent pain (3 months)
* fluency in finnish language

Exclusion Criteria:

- a psychiatric illness that significantly impairs functioning
Immediate Versus Delayed IUD Insertion After Second Trimester Medical Abortion

The main objective of the study is to compare use, in a randomised controlled trial, of the the copper IUD if inserted immediately after completion of a second trimester medical abortion, to standard care with insertion 3-4 or more weeks after abortion at community health centres.


Eligibility Criteria:
Inclusion Criteria:

* Able to speak English, Afrikaans or Xhosa;
* Requesting and eligible for abortion according to standard practice at the hospital;
* Gestational age 13-20 weeks verified by ultrasound;
* Interested and eligible for the copper IUD as a post-abortion contraceptive method;
* Willingness to participate in the trial including follow-up;
* Able to provide a working phone \& telephone number to allow for contact;
* Willing and able to provide informed consent
* Staying within one hour travel time of GSH

Exclusion Criteria:

* Active pelvic inflammatory disease, pelvic tuberculosis; severe thrombocytopenia;
* Positive N. Gonorrhea or C. Trachomatis that has not been adequately treated
* Copper allergy
* Hb \<10g/dL
* Uterine anomaly preventing placement of the IUD; cervical cancer or carcinoma in-situ, untreated high grade squamous intraepithelial lesions
* Hemorrhage; or ruptured uterus
* History of ectopic pregnancy
* Wilsons' disease
Does Probiotic Supplementation Prevent Kidney Injury During Strenuous Physical Exercise?

Severe heat strain arising from intense physical work under climate conditions that does not allow sufficient heat dissipation may lead to heat stroke. This severe conditions is hypothesized to be secondary to increased gut permeability and leakage of bacterial toxins across the gut membrane, stimulating a systematic inflammatory response and associated organ injury. Repeated such sub-clinical increases in gut permeability has been suggested to contribute to the high burden of chronic kidney disease among heat-stressed workers. Many marathon runners experience a transient increase in kidney injury biomarkers while running. Probiotics have been studied as a way to decrease gut permeability and reduce systemic inflammation in many settings, including in athletes . However, no study has measured renal outcomes among workers or athletes performing strenuous activity. This is of interest as it could test the hypothesis that gut-induced inflammation is a driver of kidney injury during heat stress, and could point to a possible intervention to add on to efforts to relieve heat strain.

In the present study, recreational or professional runners will be randomized to take a probiotic supplement or placebo during a 4 week period preceding a strenuous physical exercise (minimum 21 km run). Urine samples will be taken before and after the run, and analyzed for markers of renal injury and inflammation.

Participants registered to run in organised half-marathons, marathons and ultramarathons in Southern Sweden will be recruited. They will be asked to abstain from probiotic supplementation (including functional foods with probiotics) for 2 weeks, and then commence a 4-week period of probiotic or placebo supplementation.

At the end of the 4 week treatment period, the participants run the race. Urine samples are taken before and after the race and analysed for kidney injury markers.

Stool samples are taken by participants at the initiation of the treatment period, last stool before the race, and first stool after the race.

Eligibility Criteria:
Inclusion Criteria:

* Planning to run one of the long-distance races included.

Exclusion Criteria:

* Not having run at least 21 km previously,
* smoking,
* living too far away from the study area,
* unwilling to abstain from probiotic supplementation during treatment period,
* unwilling to abstain from NSAIDs or gut-permeability lowering supplements before the run,
* regular use of prescribed drugs (including hormonal contraceptives).
Does Sildenafil Increase Exercise Performance in Air Pollution?

The purpose of this study is to examine if the ingestion of a standard dose of sildenafil enhances the athletic performance of competitive athletes when exercising in a high pollutant environment verses a low air pollutant environment.

This study will evaluate effects of sildenafil on exercise performance while breathing high levels of emission exhaust ultrafine and fine particulate matter. Exercise performance will be measured by work accumulation (total kJ) during a 6-min maximal effort cycle ergometer ride (CER) done immediately after 30 min cycling at 75% of 6 min mean watts determined from familiarization trial. Peak oxygen consumption, cardiac output, pulmonary artery pressure, diffusion capacity(DLco), and SaO2 will be determined for each trial. Blood and urine will be analyzed for sildenafil using LC/MS.

Eligibility Criteria:
Inclusion Criteria:

* non-asthmatic
* asthmatic
* active participants in endurance sports.

Exclusion Criteria:

* history of high blood pressure
* history of heart disease
* pulmonary arterial hypertension
* pulmonary emboli
* diagnosis of moderate to severe asthma (FEV1 \<75% predicted)
* pregnant or lactating
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness

This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care rehabilitation in Sweden. Patients' disease characteristics and the treatment in multidisciplinary patient centered teams for intensive care, weaning from mechanical ventilation and simultaneous rehabilitation will be described. Patients will be followed one year after discharge to document health related quality of life, physical function, frailty, mental illness and used health care resources.


Eligibility Criteria:
Inclusion Criteria:

Admission to unit (Remeo, Stockholm, Sweden) Treated for prolonged critical illness

Exclusion Criteria:

Treated less than 48 hours at unit (Remeo, Stockholm, Sweden)
Comparison of the Effects of Neostigmine With Sugammadex on Postoperative Nausea and Vomiting.

Postoperative nausea and vomiting is one of most common complications after general anesthesia. Female sex, history of postoperative nausea and vomiting, motion sickness, non smoker status, opioid administration are known as risk factors for developing postoperative nausea and vomiting.

It has been suggest that antagonism of residual neuromuscular block with a mixture of neostigmine and atropine at the end of the surgery increases the risk of postoperative nausea and vomiting.

Sugammadex is a very safe drug with almost no serious adverse effects. The known adverse effects include slight coughing, movement, an altered taste sensation in the mouth, transient prolongation of the QT interval, hypersensitivity, and a short term prolongation of the activated partial thromboplastin time.

The aim of this study was to compare the sugammadex versus neostigmine plus atropine for reversal of rocuronium induced neuromuscular blockade in terms of incidence of postoperative nausea and vomiting.


Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status 1 and 2
* endotracheal intubation and general anesthesia scheduled for elective surgery

Exclusion Criteria:

* age \< 18 years, \> 65 years
* pregnancy
* refusal to participate and patients already participating in another study
* allergy to study drugs
* communication difficulty
* psychiatric and neurological disorders
* use of analgesics or sedative or antiemetic drugs within 24 hours before surgery.
* emergency surgery
* history of drug or alcohol abuse
* ASA 3 and above
* patients with vertigo
* Laparoscopic surgery, oncologic surgery, strabismus and mid ear surgery neurosurgery, gynecologic surgery, breast surgery
Combined Effects of Game Profile-based Training and Small-sided Games Among Football Players

Game profile-based training is a methodology in sports, including football, where training sessions are designed to simulate the specific conditions and challenges that players face during actual games. Coaches analyze individual and team performance data to identify patterns, positions, and scenarios commonly encountered in matches. The training is then structured to replicate these situations, helping players develop the skills, tactics, and decision-making abilities required in real-game scenarios.

This approach aims to make training more targeted and relevant to the dynamics of competitive play, whereas small-sided game in football, often referred to as a "SSG," is a practice or training activity where players compete in a reduced playing area with fewer players than a full team. Small-sided games can vary in size, ranging from 1v1 to 7v7 or 8v8 formats, so integrating game profile-based training with small-sided games creates a comprehensive developmental approach, addressing specific skill needs while providing a dynamic and realistic training environment. This combination can contribute significantly to the overall improvement of football players and the research also involves analyzing the impact of this integrated training methodology on players' technical strength, endurance, and overall performance.

Eligibility Criteria:
Inclusion Criteria:

* Male players
* Age 18-30 years
* Representation of players from various positions
* Players with good health and fitness status
* Participants willing and available for regular assessments
* Athletes playing football with minimum 2-year experience.

Exclusion Criteria:

* Players not actively involved in training and competition
* History of systemic disease
* Prior surgery history
* Participants with irregular attendance or significant deviations from the prescribed training program
* Pre-existing knee pathologies or injuries
* Exclusion of individuals unwilling or unable to participate in regular assessments
Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs

To study the safety and clinical effect of injection of drug-eluting microspheres with multiple chemodrug and/or protein drugs into advanced solid tumors.

Drug-eluting microspheres such as DC-beads will be loaded with IL2, PD1/PDL1/CTLA4 antibody, or /and VEGF/VEGFR antibody with or without doxorubicin/idarubicin for various time and injected into tumors under CT guidance. Side effects and treatment efficacy after injection of drug-eluting microspheres into malignant tumors will be assessed according to RICEST1.1 standard.

Eligibility Criteria:
Inclusion Criteria:

* Solid advanced malignant tumors
* Age between18 and 99 years
* Life expectancy is greater than three months

Exclusion Criteria:

* Benign tumor
* Life expectancy is less than three months
* Serious medical comorbidity
* Others
Hammock Position and Kangaroo Care

This study was planned to evaluate the effectiveness of two positions that may have an effect on pain, stress, comfort and physiological parameters in premature infants.

Providing adequate therapeutic positioning in preterms can minimize postural abnormalities and asymmetries associated with prematurity and NICU stay, as well as support the development of spontaneous and functional motor abilities of infants. Studies show that positioning directly affects cardiovascular, respiratory and sleep-wake states. When the literature is examined; Although the vital signs, pain levels and comfort levels of babies in the NICU have been examined in many applications, the number of studies comparing the hammock position and Kangaroo care in preterms is very limited. Therefore, this study will try to determine the effect of hammock position and kangaroo care on the pain, stress, comfort and physiological parameters of the infants. It is thought that the study will provide new data to the literature and lead to many researches.

Eligibility Criteria:
Inclusion Criteria:

* Infants having at least 2 days of inpatient treatment from,
* Infants 32-36+6. being born during the gestational week,
* Infants not receiving a medical diagnosis other than prematurity (serious respiratory, cardiological, endocrine and metabolic problems, hearing problems, hypoglycemia and sepsis),
* Apgar score above 6 at the 5th minute Infants will included.

Exclusion Criteria:

* Infants having at least 2 days of inpatient treatment from,
* Infants 32-36+6. being born during the gestational week,
* Infants not receiving a medical diagnosis other than prematurity (serious respiratory, cardiological, endocrine and metabolic problems, hearing problems, hypoglycemia and sepsis),
* Apgar score above 6 at the 5th minute Infants will included.
A Study of Oral Suberoylanilide Hydroxamic Acid (Vorinostat) in Patients With Solid Tumors (0683-048)

This is a clinical study to evaluate the safety and pharmacokinetics of an overseas determined maximum tolerated dose (MTD) of MK-0683 (vorinostat) in a Japanese patient population with solid tumors.


Eligibility Criteria:
Inclusion Criteria:

* Patients with histologically or cytologically diagnosed solid tumor in whom no standard therapy is available or the malignancy is refractory to standard therapy

Exclusion Criteria:

* Patients with history of immunotherapy, radiotherapy, surgery, or chemotherapy during the previous 4 weeks
* Any uncontrolled concomitant illness
* Pregnant or breast-feeding
* Serious drug or food allergy