cyrilzakka/clinical-trials huggingface dataset:
The Effect of Kinesio Taping® on Motor Control in Patients With Patellofemoral Pain Syndrome

Background: Recently, several professionals are using the Kinesio Taping® in the treatment of pathologies related to the knee, aiming to improve the motor control, increase the response of muscle activation and promoting better joint stability.

Purpose: The objective of this study is to evaluate the effect of the application of Kinesio Taping® in motor control of patients with patellofemoral pain syndrome.

Methods: This is a 2-arm, randomized with a blinded assessor. We selected 40 women with patellofemoral pain (age 25.2±4,years) were randomly assigned to one of two groups: placebo group (n= 20) and the Kinesio Taping® group (n=20). The placebo group received the application of a non-stretchable tape (Micropore) crosswise on the thigh and the Kinesio Taping® group followed all the criteria of the method in placing the bandage. All patients received the evaluation of the motor control banding pre and post a patch, by means of the method Y balance test.


Eligibility Criteria:
Inclusion Criteria:

* Patellofemoral pain syndrome diagnoses
* Aged 18-40 years
* Kujala questionnaire above

Exclusion Criteria:

* Neurological disorders
* BMI indicating obesity (BMI\> 30kg / m²)
* High-performance athletes
* History of surgeries in lower limbs
* In treatment of any underlying pathology
Characterisation of Objectively Measured Physical Activity and Self-reported Habitual Exercise

This study aims to observe participants' physical activity (PA) using a blinded multisensor physical activity monitor as they go about their typical daily physical activities across a 6-week time frame. Participants will also complete a subjective, self-reported, online form to denote structured activities undertaken.

This study will observe participants' objectively measured PA and energy expenditure in a naturalistic manner. Individuals expressing interest will be invited to attend an online familiarisation meeting to assess eligibility for the study - procedures will be presented/explained in detail before participants are given a chance to question and discuss any concerns. Once aware of the requirements, participants will be asked if they wish to take part in the main trial and asked for written informed consent.

In Visit 1 (Day 0) willing participants will then undergo a familiarisation of protocol components, and they will be provided with the SenseWear armband to be worn, constantly, over a 42-day period (except during water-based activities such as showering and swimming). The device does not include a display and so participants are blinded to the measurement. Participants will be instructed to continue with their normal lifestyles and not make any changes. On or around day 43, participants will be asked to return the device (Visit 2).

During visit 1 and visit 2 participants will be measured and weighed using a stadiometer and floor scale. Throughout the trial, weekly reminder emails will be distributed by the research team to all participants reminding them of the study requirements and providing them with an additional opportunity to raise concerns. Due to the data storage capacity of the devices, new monitors will be distributed and used monitors returned remotely via post at weeks 2 and 4.

Additionally, during this period of objective PA measurement, participants will be invited to note the start and end time of any 'structured exercise' - defined as any PA that is "planned, structured, repetitive and aimed at improving or maintaining physical fitness (Caspersen, Powell and Christenson 1985 cited by Simmich, Deacon and Russell 2019)". Participants will also be required to note time spent sleeping. Data from this self-report component of the trial will be used to demarcate bouts of purposeful, structured exercise as well as total self-reported waking time.

Eligibility Criteria:
Inclusion Criteria:

* Healthy adults aged 40-70.
* Available to attend Department for Health, University of Bath, Bath, UK.
* Capable of conducting typical daily task (e.g., housework, walking etc.).
* Willingness to wear a PA monitor for 24hr for a total of 42 days.

Exclusion Criteria:

* No cold/flu-like symptoms within the last month.
* Smokers.
* Known history of cardiac or circulatory dysfunction.
* Known to live with diabetes or other metabolic disorders.
* Known to live with severe visual or audio impairment.
* Known to live with epilepsy or have seizures.
* Known disabilities that impede daily physical activity.
* Known allergy to nickel.
Quality of Life and Decisional Regret in Patients Affected by Acoustic Neuroma

Italian translation and validation study of two different questionnaire (VSQOL and DRS) about quality of life in patient with acoustic schwannoma.


Eligibility Criteria:
Inclusion Criteria:

* Patient with sporadic acoustic neuroma in follow-up with wait and scan protocol or treated with microsurgical resection with any approach

Exclusion Criteria:

* Patient with NF2
* Patient previuosly treated with RT in the head and neck district
* Patient with pre-treatment facial palsy ipsi and controlateral
* Patient non native italian speakers
* Patient with major mental illness already existing before the acoustic neuroma diagnosis
* Patient with neurological issues such as chronic migraine or postural instability already existing before the acoustic neuroma diagnosis
Diagnosis of Nodules ≤2 cm Based on US and CEUS Compared With Current Clinical Procedure

Due to different etiologies, diagnosis and treatment of HCC in China is different from that in Western countries.US is an important screening method for HCC in patients with liver cirrhosis. CEUS, as an enhanced imaging method based on US, has the advantages of convenience, non-radiation, low cost, short examination time, and the diagnostic performance of HCC is comparable to that of CECT, CEMRI, and hepatobiliary-specific MRI.

It is of great significance to consider the cost-effectiveness of each examination based on the principle of cost minimization. Therefore, we propose immediate CEUS examination for suspicious lesions ≤2 cm screened by US, and determine the diagnostic process of further diagnostic methods based on the CEUS results. The aim of this study is to establish a screening and diagnosis process for HCC ≤2 cm suitable for China considering time effect, economic effect and diagnostic efficiency.


Eligibility Criteria:
Inclusion Criteria:

1. Patients are at high risk of HCC.
2. The ages of patients are between 18 and 80.
3. Patients are with solid liver lesion(s) ≤ 2 cm detected by US.
4. Patient signs the informed consent.

Exclusion Criteria:

1. Patients are with liver cirrhosis due to congenital hepatic fibrosis or due to hepatic vascular diseases such as hereditary telangiectasia, Budd-Chiari syndrome, chronic portal vein occlusion syndrome, congestive heart disease.
2. Patient's age is \< 18 years old or \> 80 years old.
3. Patients with known hypersensitivity to CEUS, CECT, CEMRI, or hepatobiliary-specific MRI contrast agents.
4. Patient is a pregnant or breastfeeding woman.
5. Patient is not diagnosed based on the reference diagnostic criteria required by the study.
6. Patient is considered to be unsuitable to participate in the study.
Investigation of the Effect of Acupuncture Needling on Connective Tissue Using Ultrasound Elastography

During acupuncture treatment, acupuncture needles are inserted and manipulated until a characteristic local tissue reaction termed "de qi" is observed. De qi can be perceived by the acupuncturist in the form of "needle grasp", a mechanical gripping of the needle by the tissue. De qi is considered essential to the therapeutic effect of acupuncture. Therefore, the investigator proposes that understanding this local tissue reaction will lead to an understanding of how the therapeutic effect of acupuncture therapy arises. Specifically, it is hypothesized that needle manipulation causes winding of collagen and elastic fibers around the needle. This action induces tension in the collagen network surrounding the needling site and results in a mechanical signal that is transduced into local cells. The objective of the current work is to use ultrasound elastography, a recently developed ultrasound imaging technique, to visualize and quantify changes in the elastic properties of skin and subcutaneous tissue in 12 healthy human volunteers as a result of acupuncture needle manipulation.


Eligibility Criteria:
Inclusion Criteria:

* Healthy
Optimizing Antibiotic Use in Long Term Care

The purpose of this study was to determine if a multi-faceted intervention to implement diagnostic and therapeutic algorithms for management of suspected urinary infection in nursing home residents could reduce antibiotic prescribing for urinary indications in this population.

Antibiotic use is intense in nursing homes and frequently inappropriate when prescribed for urinary indications. Evidence from randomized controlled trials suggests that treatment of asymptomatic bacteriuria, the presence of bacteria in the urine in the absence of urinary symptoms, is not beneficial. Despite this, one in three prescriptions for urinary indications are for asymptomatic bacteriuria. To improve antibiotic prescribing in this setting we conducted a cluster randomized trial of a strategy to implement diagnostic and treatment algorithms for urinary infection. 24 nursing homes were randomized to either the intervention (implemented at the nursing home level using a multi-faceted approach: small group interactive sessions for nurses, one-on-one interviews for physicians, videotapes, written material, and outreach visits) or to usual care.

Eligibility Criteria:
Inclusion Criteria:

1. Individuals- all residents eligible
2. Nursing homes

   * Free standing long term care facilities with \>100 beds
   * No stated policy for diagnosis or treatment of urinary tract infections
   * The facility agrees to refrain from introducing new strategies for antibiotic utilization or clinical pathways during study

Exclusion Criteria:

-
Creatine Effect on Brown Adipose Tissue Activation

Pre-clinical studies indicate that creatine may play a substantial role in diet-induced thermogenesis and may have a profound effect on energy balance. A recent retrospective study of BAT activation on PET-CT scans in humans showed a positive association with the estimated renal creatinine clearance and BAT activation, possibly linking creatine metabolism in humans to BAT activity. In humans, so far little options are available to activate brown adipose tissue. The most potent intervention to activate BAT is via cold, which has previously been shown to have metabolic effects in humans. Provided the potential health benefits of brown adipose tissue activation in humans, and provided the role of brown fat in diet induced thermogenesis, we here aim to determine whether creatine monohydrate supplementation can increase diet-induced thermogenesis and activate brown adipose tissue in humans.


Eligibility Criteria:
Inclusion Criteria:

* Male or female;
* 18 to 30 years of age;
* Consuming a vegetarian diet;
* BMI 20-25 kg/m2.

Exclusion Criteria:

* Not meeting all inclusion criteria;
* Non-vegetarian diet;
* Excessive alcohol and/or drug abuse;
* Significant allergies or intolerances concerning the study products;
* Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
* Medication use known to hamper subject's safety during the study procedures;
* Subjects with contra-indications for MRI and/or PET-CT;
* Subjects who do not want to be informed about unexpected medical findings;
* Subjects who do not want that their treating physician to be informed;
* Co-morbidities to which the intervention or program that may pose as a complicating factor;
* Inability to participate and/or complete the required measurements;
* PET-CT scan in the last 12 months.
[11C]Cimbi-36 Dosimetry

The purpose of this study is to determine the dosimetry for the Positron Emission Tomography (PET) tracer \[11C\]Cimbi-36 in two different Carbon-11 labelling positions. This information will contribute to determining whether \[11C\]Cimbi-36 can be optimized by changing the C-11 labelling position.

Healthy subjects wil undergo a whole-body Positron Emission Tomography (PET) scan with the Serotonin 2A Receptor (5-HT2A) radioligand \[11C\]Cimbi-36 or \[11C\]Cimbi-36-5 to determine the effective radiation dose and radiation dose for selected organs.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age
* Signed informed consent

Exclusion Criteria:

* Present or former neurological disease, severe somatic or psychiatric disease, or medication thet can interfere with the test results.
* Pregnancy at the time of the scan
* Breastfeeding
* Alcohol or substance abuse
* Exposure to radiation (\>10 millisievert (mSv)) within the last year, or significant exposure at work
* Allergy to any of the substances in the Investigational medicinal product (IMP) formulation
Personal Health Records and Elder Medication Use Quality

Purpose: To examine the impact of a personal health record (PHR) on medication use safety among older adults.

Background: Online PHRs have potential as tools to manage health information. We know little about how to make PHRs accessible for older adults and what effects this will have.

Methods: A PHR was designed and pretested with older adults and tested in a six-month randomized controlled trial. After completing mailed baseline questionnaires, eligible computer users aged 65 and over were randomized 3:1 to be given access to a PHR (n=802) or serve as a standard care control group (n=273). Follow-up questionnaires measured change from baseline medication use, medication reconciliation behaviors, and medication management problems.


Eligibility Criteria:
Inclusion Criteria:

* Computer use within the past month.
* Age 65+
Long-Term Effects of Torso-Weighting

The goal of this pilot study is to test the protocol for investigating the longer-term effects of torso weighting on physical activity, number of falls, and muscle activation (when muscles turn on and off and how intensely) in five volunteers with multiple sclerosis. The hypotheses of this study include: torso weighting will (1) increase physical activity, (2) decrease the number of falls, and (3) improve the timing and coordination of muscle activation during balance perturbations.

Torso weighting, using the balance-based torso-weighting (BBTW) method, is an intervention that addresses balance by first challenging stability in standing using a series of perturbations (nudges) and resisted rotations to people. Challenging stability allows the assessor to determine directional instability. Once the direction of instability is determined, small weights are placed on a vest-like garment and retesting of balance occurs. In this study, participants will be tested with no weights (NW), with sham weights (SW), and with BBTW weighting (WT). Following non-weighted baseline assessment, participants will be randomly allocated into the sham weight condition or BBTW weight condition in a cross-over design. The initial condition (NW) will last four weeks and the final two conditions (SW,WT) will last two weeks each. Following each condition, outcome measures will be reassessed. Throughout the study, participants will be asked to wear a commercially-available remote monitoring device (e.g., Fitbit Flex) and keep a daily log of physical activity and number of falls. During the SW and WT conditions, participants will wear the assigned garment for 2-4 hours daily.

Eligibility Criteria:
Inclusion Criteria:

* Self-reported a diagnosis of multiple sclerosis
* Self-reported mild or moderate gait or balance difficulties
* Living in the community rather than in a care facility
* Able to walk independently for at least one minute at a time with or without an assistive device
* No exacerbations within the past 2 months
* Able to get to the testing area and tolerate 2-3 hours of testing for each assessment occasion
* Willing to be nudged by a researcher when standing

Exclusion Criteria:

* Unable to comprehend and follow instructions in English
* Current diagnosis of other neurological disorders such as head injury, stroke, Parkinson disease, or other conditions that affect gait or balance (self-reported)
* Experiencing pain that could be exacerbated by external perturbation while standing
* History of skin reaction to adhesives
A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

This study is researching an experimental drug called linvoseltamab ("study drug").

This study is focused on patients who have AL amyloidosis that has returned or have failed other therapies and need to be treated again.

The study consists of 2 phases (Phase 1 and Phase 2):

* In Phase 1, linvoseltamab will be given to a small number of participants to study the side effects of the study drug and to determine the recommended doses of the study drug to be given to participants in Phase 2.
* In Phase 2, linvoseltamab will be given to more participants to continue to assess the side effects of the study drug and to evaluate the ability of linvoseltamab to treat AL amyloidosis.

The study is looking at several other research questions, including:

* How many participants treated with linvoseltamab have improvement in the abnormal proteins that cause organ problems and for how long
* How many participants treated with linvoseltamab have improvement in the heart or kidney and for how long
* What the right dosing regimen is for linvoseltamab
* What side effects may happen from taking linvoseltamab
* How much linvoseltamab is in the blood at different times
* Whether the body makes antibodies against linvoseltamab (which could make the drug less effective or could lead to side effects)


Eligibility Criteria:
Key Inclusion Criteria:

1. Confirmed diagnosis of AL amyloidosis, as described in the protocol
2. Measurable disease as defined by serum difference between involved and uninvolved free light chains (dFLC) concentration, as described in the protocol
3. Previously treated after at least 1 prior therapy and requiring further treatment as assessed by the Investigator
4. N-terminal pro b-type natriuretic peptide (NT-proBNP) ≤8500 ng/L during screening
5. Adequate hepatic, hematologic, renal, and cardiac function, as described in the protocol
6. Eastern Cooperative Oncology Group (ECOG) performance score ≤2 at screening

Key Exclusion Criteria:

1. History of other non-AL amyloidosis
2. Greater than 60% plasmacytosis on a bone marrow biopsy and/or aspirate during screening
3. Presence of lytic bone lesion(s) or extramedullary plasmacytoma on imaging during screening
4. Myocardial infarction within the past 6 months prior to the first screening visit
5. Known active infection requiring hospitalization or treatment with IV anti-infectives within 28 days of first administration of study drug

NOTE: Other protocol defined inclusion/exclusion criteria apply
Learning Experience of Undergraduate Nursing Students in Pediatric Oncology Ward

Clinical practices are crucial experiences for nursing students as they prepare themselves for future nursing work. Despite some research having been studied among Taiwanese nursing students in the past, there has been limited research into the experiences within pediatric oncology wards, where diseases are complex and frequently involve life-and-death issues. Therefore, the purpose of this study is to explore the experiences of undergraduate nursing students in pediatric oncology wards.

Pediatric cancer is the leading cause of death in Taiwan for children aged 1-14. Despite advances in cancer diagnosis and treatment technology, pediatric cancer still requires highly professional and holistic health care. For healthcare professionals, it is a very challenging task. It can be assumed that for nursing students, the pressure of caring for children with cancer must be considerable. Additionally, pediatric care emphasizes family-centered care, meaning that during their clinical practices, nursing students not only need to learn skills related to caring for diseases but also understand the impact of cancer care on caregivers. This may lead to frustration or discouragement and potentially affecting their future careers in pediatric oncology wards Existing studies on nursing student clinical practice experiences in other wards have found that many nursing students have poor experiences due to insufficient technical skills, knowledge, and communication issues with both families and children. Therefore, utilizing qualitative research methods to understand nursing students' clinical practice experiences in pediatric oncology wards is crucial for identifying their learning needs and challenges. This study will involve in-depth interviews lasting for 30-60 minutes with nursing students who have completed their clinical practice in pediatric oncology wards, using semi-structured interview guides to elicit their experiences.

Eligibility Criteria:
Inclusion Criteria:

* Undergraduate nursing students in Taiwan
* Experienced clinical practice in pediatric oncology ward
* Who can describe their experiences in Chinese
* Understand and agree the purpose of this study

Exclusion Criteria:

* Not Undergraduate nursing students in Taiwan
* Haven't experienced clinical practice in pediatric oncology ward
Multiple Sclerosis and Heavy Progressive Resistance Training

The purpose of the present investigation is to determine whether MS patients can tolerate and benefit from heavy progressive resistance training. A second purpose is to determine both neural and muscle morphological adaptations to heavy progressive resistance training.

Multiple sclerosis (MS) patients are characterized by reduced muscle strength and functional capacity. For MS patients, improvements in muscle strength and thereby functional capacity, would have the potential to make both the daily living easier and to extend the time living independently. Attempts to improve muscle strength and function include the application of physical training, although the general advice to MS patients for many years has been to avoid participation in physical training. It has now been demonstrated that endurance training at low to moderate intensity is well tolerated by MS patients, but it only induces modest improvements in both muscle strength and functional capacity. Heavy progressive resistance training (HPRT) has proven to be the most effective means to improve muscle strength and functional capacity during daily activities in healthy older people. However, the effects of HPRT have not been investigated in randomised control trials in MS patients.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of Relapsing Remitting Multiple Sclerosis according to the McDonald criteria
* Expanded Disability Status Scale Score between 3,0-5,5
* Be able to walk at least 100m
* Be able to train twice a week at the University

Exclusion Criteria:

* Alcohol abuse, Alzheimer's and pacemaker
* Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases
* Having had an attack in a period of 8 weeks prior to the start of the intervention period
* Having an attack during the intervention period
* Pregnancy
* Systematic resistance training in a period of 3 months prior to the start of the intervention period.
* Training adherence of less than 85%.