cyrilzakka/clinical-trials huggingface dataset:
Early or Non-revoked in Hospital-day in Patients With Acute Heart Failure

Heart failure is one of the major causes of hospitalization in Brazil and worldwide. Recent studies attempt to identify readmission and prognostic markers at the time of discharge from these patients. The reassessment and possibility of early therapeutic adjustment may be relevant in this context. Therefore, the prospective and randomized comparative use of early re-evaluation in Hospital-day versus non-intervention group has not yet been described. The objective of this study was to evaluate the impact on the re-hospitalization rate in 30 days of the early re-evaluation of the patients in the day-hospital versus the non-intervention group in heart failure. For this, a unicentric, randomized and prospective study will be performed, in which the Hospital-Day strategy is performed versus no intervention in a comparative manner. Hospital data (test results, medical outcomes, complications) of patients will be analyzed for safety and effectiveness. The hypothesis of this study is that the Hospital-Day strategy is superior to the non-intervention strategy and causes fewer rehospitalizations within 30 days.


Eligibility Criteria:
Inclusion Criteria:

* Adult men and women aged\> 18 years.
* Presence of decomposed CF III or IV of NYHA characterized by\> 1 symptom (dyspnea, orthopnea or edema) + 1 clinical sign (rales, edema, ascites or pulmonary congestion on chest X-ray).
* LVEF \<45% on transthoracic echocardiography.
* BNP\> 400 pg / mL.
* Clinical condition of hospital discharge.
* Signed consent form.

Exclusion Criteria:

* Pregnancy
* Body mass index greater than 40 kg / m2.
* Chronic obstructive pulmonary disease.
* Acute coronary syndrome.
* Acute myocarditis.
* Valvular heart disease.
* Need to use vasoactive drug.
* Cirrhosis of the liver Child C.
* Chronic dialysis renal insufficiency or creatinine\> 3.0 mg / dL.
* Indication of implantation device of artificial stimulation.
* Pulmonary thromboembolism.
* Neoplasm terminal.
* Sepsis or septic shock.
The Use of Composite Bone and Nail Bed Graft Combined With Cutaneous Flaps for Reconstruction of Finger Tip Amputations

Fingertip injuries are among the most common hand injuries regardless of age, as the fingertip is a prominent and frequently used part of the hand. However, no consensus yet exists regarding the ideal reconstruction of fingertip injuries with nail bed defects, and its reconstructive methods are limited.

Allen has classified fingertip amputations into four types. Type I injuries involve only the pulp of the finger. Type II includes pulp and nail loss. Type III has partial terminal phalanx loss and corresponding pulp and nail loss. Finally, type IV involves the lunule of the nail, pulp, nail, and partial loss of the terminal phalanx.

Fingertip amputations through the proximal half of the nail-bed are challenging as the remaining nail-bed has inadequate length for satisfactory nail growth. Replantation at this level gives a good functional and cosmetic results but is technically demanding, requires microsurgical skills and adequate facilities and is not always possible.When replantation is not possible, the use of a local advancement palmar flap preserves digital length and the remaining nail bed.

However, when the amputation is through the proximal third of the nail, this technique leaves very little nail bed and nail deformities are common.To avoid these deformities, complete ablation of the nail bed and germinal matrix with closure by a palmar advancement flap, or by shortening, are usually carried out. Unfortunately, these treatments often fail to satisfy the patient's desire to retain his or her nail.

When replantation is not feasible, the technique of advancing a palmar V-Y flap and applying the nail bed retrieved from the amputated part to the dorsum of the flap provides an alternative means of restoring nail bed length. So the technique of using composite bone and nail bed graft from the amputated part with a local or regional cutaneous flaps may be an option for treatment of fresh fingertip amputation to restore the shape and preserve the length of the fingertip especially in circumstances when microsurgical replantation is not feasible.


Eligibility Criteria:
Inclusion Criteria:

* Any level of finger tip amputations through the nail bed and distal phalanx with preserved amputated part.

Exclusion Criteria:

* Crushed part of amputated segment.
* Patients with peripheral vascular disease.
* Diabetic patient.
* Pateint over 65 or under 5 years of age.
* Patient refusal.
Risk Adapted SABR(SABR) in Stage I NSCLC And Lung Metastases

This study is designed to evaluate the safety of Stereotactic Ablative Radiotherapy (SBRT) in selected patients with stage I Non Small Cell Lung Cancer (NSCLC) or metastatic lung cancer to demonstrate the feasibility and risks of using an ablative dose-adapted scheme with FFF beams. Other aims are To evaluate the incidence of acute and late complications; To evaluate tumour response to local radiation therapy by means of CT, PET/TC and MRI and To evaluate the impact of local therapy on overall and disease-free survival.

The intervention (dose and fractions) depends on topographical parameters: lung disease (primary, peripheral nodes or mediastinal nodes), distance to chest wall, tumour size and distance to main bronchus.

Eligibility Criteria:
Inclusion Criteria:

* Histologically-confirmed primary lung cancer or lung metastasis from another primary tumour or positive PET/CT suggestive for primary tumour(SUV MAX\> 4).
* Tumour size \< 5 cm in diameter prior to treatment.
* Medically inoperable patients as determined by the multidisciplinary thoracic tumour board, or medically operable patients who refuse surgery.
* Life expectancy of \>12 months.
* Criterion for medical inoperability include:

Overall clinical assessment at the UCLA thoracic tumour board. Reduced Pulmonary Function (FEV1, DLCO, etc) based on one major or two minor criterion as described below: Minor Criteria: Age \> 75, FEV1 51- 60% predicted, or FEV1 1-1.2L, DLCO 51%-60% predicted, pulmonary hypertension, poor left ventricular function (EF \< 40% or less), resting or exercise arterial pO2 \< 55 mmHg, and pCO2 \> 45 mmHg.

* Age \> 18 years.
* KPS \> 70.
* Barthel score \>40
* Baseline computed tomography scans of the chest, pulmonary test function, and positron emission tomography no more than 2 months before treatment.
* If a woman is of childbearing potential, a negative urine or serum pregnancy test must be documented.
* Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

* Prior thoracic radiation treatment wich dose contribution can be expected in the new SBRT plan.
* More than two lesions per lobe.
* Active infections requiring systemic antibiotics.
* Age \<18 years old.
* KPs \< 70.
* Barthel Total Score \< 40.
The Effect of Plyometric Training in Freestyle Adolescent Wrestlers

This study aims to determine the effect of plyometric exercises on physical fitness parameters in freestyle adolescent wrestlers.

Plyometric exercises are an effective training method that converts strength gains into power by applying specific power (explosive force) training. Plyometric training also dramatically contributes to converting acquired strength into wrestling-specific power. In light of this information, the relatively scarce literature on plyometric training with wrestlers, particularly adolescent freestyle wrestlers, will be studied. This study examines the effects of different plyometric training on physical fitness parameters in adolescent freestyle wrestlers over eight weeks.

The investigators will involve participants who meet the inclusion criteria and who will be randomly assigned to either the control or training group. The training group will undergo plyometric exercise training twice a week for eight weeks in addition to their regular training program. Conversely, the control group will continue their regular training program without additional interventions. Evaluations will be conducted at the beginning and end of the eight weeks to assess the effects of the plyometric training.

The routine training program for the control group participants includes basic strength training (weightlifting exercises), cardiovascular training (biking, running, sprint training, jogging), technical and tactical training, and match-style wrestling. The plyometric training program will be implemented twice a week for 8 weeks, with the number of sets and repetitions of the exercises adjusted weekly to ensure a progressive and safe training regimen.

The investigators will assess the evaluation criteria at the beginning and end of the 8-week training period, comparing pre- and post-training data and conducting intergroup comparisons. Two measurements will be recorded according to these parameters. By the end of the study, the investigators will provide a comprehensive analysis of the impact of the plyometric training program on the physical fitness parameters of freestyle adolescent wrestlers, supported by robust data.

Eligibility Criteria:
Inclusion criteria for the study:

* Individuals engaged in freestyle wrestling sport with a valid license,
* Aged between 10 and 15 years old,
* Have been practicing this sport for at least three years,
* Not involved in any other sports discipline,
* Willing to cooperate and volunteer for the study,
* The research will include those who have not received medical treatment in the last three months and will not receive treatment during the study period.

Exclusion criteria for the study:

* Individuals with injuries and chronic pain,
* Smokers,
* Regular medication users,
* Those with neurological and systemic diseases,
* Individuals who have experienced trauma and undergone surgery in the last three months,
* Athletes who withdraw their voluntary participation
Molecular Epidemiology of Biliary Tree Cancers

This study is to learn if certain risk factors (environmental, viral, behavioral, medical, and dietary), tumor markers, and genetic changes can predict the development and outcome of biliary tree cancers. Establishing biomarkers models from patients may help doctors to further understand how biliary tree cancer is affected by different treatments, and why some people's cancer responds differently than others.

PRIMARY OBJECTIVES:

I. To identify significant factors that may contribute to the etiology of biliary tree cancer.

II. To identify novel genetic loci that predispose to gallbladder cancers (GBC) and cholangiocarcinoma (CGC) diagnosis.

EXPLORATORY AND CORRELATIVE OBJECTIVES:

I. To use the collected blood and tissue materials for exploratory analysis to identify markers that predict prognosis of biliary tree cancers.

II. To correlate the identified markers with results of specific aim I and II to test the interaction between the identified markers with environmental and genetic factors.

OUTLINE:

Participants complete a questionnaire over 20 minutes. Participants also undergo collection of blood and leftover tissue samples.

Eligibility Criteria:
Inclusion Criteria:

* Pathologically or radiologically confirmed diagnosis of CGC or GBC
* With or without prior radiation or chemotherapy
* All United States of America (USA) and non USA residents
* No age, gender, or racial restriction
* Healthy control with no current or history of cancer
* Healthy controls are USA and non USA residents
* Healthy controls are matched to the cases in age (5 years), gender, and race
* Healthy controls are friends and spouses of patients with other than gastro-intestinal (GI) cancers
* Chronic Liver Disease (CLD) controls with no current or history of cancer
* CLD controls are USA and non USA residents
* CLD controls are frequency matched to CGC cases by age (5 years), gender, and race
* CLD controls are patients are diagnosed with or without liver biopsy (core or fine needle aspiration)
* CLD controls must not have evidence liver cancer diagnosis by computed tomography (CT) or magnetic resonance imaging (MRI)

Exclusion Criteria:

* None
Pre-approval Access for Janssen's COVID Vaccine VAC31518 for Treating Physician Use

The purpose of this Pre-approval access (PAA) program is to provide VAC31518 (Ad26.CoV2.S) vaccine for the prevention of coronavirus disease-2019 (COVID-19) infection. This PAA program may be considered to protect participants against a serious/life-threatening diseases or conditions, where there are no alternative treatments available.


Eligibility Criteria:
Recurrent Salivary Gland Infections in Covid-19

The aim of this study is to find out the role of Covid-19 in salivary gland infection and its recurrence.

This is a prospective clinical study of 60 patients. The study will be performed in the Otolaryngology department, Faculty of Medicine, Benha University during the duration from June 2023 to December 2023.

Inclusion criteria:

Adult patients aged ≥18 years.

Exclusion criteria:

* Patients with known autoimmune diseases,
* Diabetes Mellitus
* History of cancer in the region of the head and neck or previous radio and/or chemotherapy.
* History of facial nerve palsy,
* Oral and dental diseases including chronic sialadenitis or sialolithiasis.
* previous oral surgery.

Patients were divided into two equal groups each of 30 patients according to the cause of infection. Group (1) comprises 30 patients with Covid-19 infection representing the study group COVID-19 diagnosis will be based on a positive SARS-CoV-2 nasopharyngeal swab on real-time reverse transcription-polymerase chain reaction (RT-PCR) in the presence of clinical and/or radiological signs and group (2) comprises of 30 patients with non-Covid-19 infection as a control group.

All patients will be submitted to full ENT and intraoral clinical examination. We will Compare both groups as regards patients' characteristics, risk factors, etiology, symptoms, and rate of recurrence of sialadenitis.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients aged ≥18 years with a history of CIVID-19 infection in the study group and of similar age without a history of COVID-19 infection.

Exclusion Criteria:

* Patients with known autoimmune diseases,
* Diabetes Mellitus
* History of cancer in the region of the head and neck or previous radio and/or chemotherapy.
* History of facial nerve palsy,
* Oral and dental diseases including chronic sialadenitis or sialolithiasis.
* previous oral surgery.
Study on the Relationship Between Physical Constitution and Diseases

Physical constitution is an important factor for the development and outcome of diseases according to the theory in traditional Chinese medicine.

The purpose of the study is to find the correlation between physical constitution and clinical characteristics (age, sex, symptoms, physical signs, life style, laboratory results and image findings) through the questionnaire and results of health examination.

It is difficult to predict the process or outcome of disease for individuals who expose to the same pathogen or condition. But according to the Traditional Chinese Medicine, physical constitution is an important factor for disease pattern, severity and response to the treatment. So it is paid more and more attention in Western Medicine to study the variation of individualized susceptibility to diseases.

There have been some researches to investigate the relationship between physical constitution and disease pattern. Before further studies, we need to obtain more information about physical constitution and clinical characteristics. Therefore we design a comprehensive questionnaire to survey the types of physical constitution. And we plan to collect the data from health reports of candidates after their medical tests at Health Examination Center in National Taiwan University Hospital Yu-Lin Branch. We focus on the relationship between clinical characteristics (age, sex, symptoms, physical signs, laboratory results and image findings) of Western Medicine and the physical constitutional types of Chinese Medicine. Then we will try to find the correlation and significance between them.

The study will conclude the constitutional characteristics in general population of Taiwan and the distribution tendency of physical constitution for the common diseases. The result can serve as a stepping stone for integration of the Traditional Chinese Medicine and Western Medicine.

Eligibility Criteria:
Inclusion Criteria:

* candidates with healthy report on health exam

Exclusion Criteria:

* acute infection
* chronic disease with acute exacerbation
* unstable disease status or medication
Perioperative Smoking Cessation in Elderly Chinese Undergoing Spinal Fusion

As China's society ages faster, the number of elderly patients undergoing spinal fusion surgery will gradually increase. Since elderly patients are at higher risk of postoperative complications than younger patients, minimizing complications after spinal fusion becomes a priority in postoperative rehabilitation. The purpose of this prospective cohort study is to develop an enhanced recovery after surgery program including individualized perioperative smoking cessation strategies in Chinese elderly undergoing spinal fusion.

With the aging society, elderly population in China has reached 172 million (12%) in 2020 and is predicted to rise to 336 million (26%) by 2050. This will be accompanied by more elderly people with degenerative spinal diseases who may become candidates for spinal surgery (e.g., spinal fusion). Compared with younger patients, elderly patients are more likely to experience complications after spinal fusion (e.g., 9% and 14% for \<65 and ≥ 65 years old in lumbar fusion), which may lead to adverse patient outcomes including worse functional outcomes and satisfaction and increased revision surgery.

Recently, enhanced recovery after surgery (ERAS) program for spinal fusion including the pre-, intra-, and post-operative care interventions has been developed. Previous studies have shown that ERAS has multiple benefits for elderly undergoing spinal fusion, such as reduced complications and shorter hospital stays. However, the preoperative smoking cessation protocols varied widely between studies (e.g., at least 4 weeks, 3 months, and 2 weeks before surgery), which may be due to a lack of evidence.

Therefore, we plan to conduct a prospective study to improve the perioperative smoking cessation strategy of ERAS and establish an evidence-derived protocol.

Eligibility Criteria:
Inclusion Criteria:

1. Patients aged 65 years old or more;
2. Patients who plan to undergo spinal fusion with ERAS program;
3. Patients who agreed to participate in this study.

Exclusion Criteria:

1. Patients who cannot understand the study content or have difficulty communicating;
2. Patients with a history of spinal fusion surgery;
3. Patients with spinal fractures, spinal tumor, or spinal infections;
4. Patients with congenital spinal deformity;
5. Patients who were unable to complete at least 6 months of follow-up;
6. Patients with incomplete clinical information.
Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration

The Cartilage Autograft Implantation System (CAIS) is designed as a single surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight or low weight-bearing region. CAIS is indicated for the repair of articular cartilage lesions and osteochondritis dissecans (OCD) of the knee through cartilage regeneration.

The Cartilage Autograft Implantation System (CAIS) is a kit of devices that utilizes morselized autologous hyaline cartilage harvested arthroscopically, affixed onto a synthetic, resorbable implant using a fibrin sealant and implanted in a single surgical procedure. The system is designed as a surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight or low weight-bearing region.

Eligibility Criteria:
Inclusion Criteria:

* A male or female 18 to 55 years of age,
* Has 1 or 2 focal chondral lesions, that require repair, per index knee presenting with moderate to severe knee pain. Each lesion is ≤6 mm in depth and has an area of ≥1 cm2 and ≤10 cm2. Arthroscopic confirmation indicates that the lesions are either a non-OCD lesion between grades I and III (D) or an OCD lesion between grades I and IV(A)
* Prior failed chondral treatment is allowed if the procedure occurred \> 6 months for debridement and lavage or \> 1 year for marrow stimulation techniques.

Exclusion Criteria:

* Have more than 2 chondral lesions on the index knee,
* Bipolar lesions on the index knee,
* Greater than 5 degrees of malalignment,
* Require bilateral surgery
* Have a diagnosis of clinical and/or radiographic disease of the index joint.
Enhanced Rehabilitation After Major Trauma (PROPERLY)

The goal of this study is to assess the feasibility of recruitment, and barriers to delivery of an enhanced rehabilitation service, in patients surviving major trauma.

The main questions it aims to answer are:

are the investigators able to recruit patients to a research study are the investigators able to retain patients in the research study are the investigators able to identify appropriate primary outcome measures are the investigators able to identify barriers to future large-scale definitive trial or service delivery Participants will would be offered at least two sessions of the Enhanced Rehabilitation Programme (ERP), each lasting 60-120 minutes per week, delivered in the Manchester Institute of Health and Performance (MIHP).

Participants not willing to travel to the MIHP, or declining to engage in the ERP, will be asked to join the Standard Care (SC) group. This group will provide questionnaire data and clinical outcome measure collection with their usual place of therapy.

Researchers will compare the ERP group and the SC groups to assess any additional benefits to the ERP.

The investigators will aim to recruit 25 participants for the ERP and 25 participants in SC (50 in total) who will go through a series of quantitative functional assessments and patient reported outcome measures, at baseline (at the beginning of the programme), middle (3 months), on discharge from the programme (usually 6 months). If patients are discharged earlier, assessments will be performed at the discharge visit.

Assessments using PROMS will be conducted at baseline (at the beginning of the programme), middle (3 months), on discharge from the programme (usually 6 months), and 12 months.

Eligibility Criteria:
Inclusion Criteria:

* Participants over 18 years old
* Registered GP in Greater Manchester or Greater Manchester Resident.
* Polytrauma or one or more complex /severe isolated injury
* Rehabilitation goals (e.g., mobility, function, job retention/ return to work) identified using shared decision-making process
* Patient able to enter programme 6-30 months post injury.
* For the ERP patients willing to travel to the MIHP for their evaluation and treatment twice a week.
* Participants with lower limb injuries that continue to have functional impairment.
* Participants deemed well and safe enough to participate by clinical teams.
* Normal ECG if previously reported to have abnormal ECG
* Participants willing to consent to follow up over 12 months
* Participants with the capacity to consent to the study.
* Fully healed wounds and bone healed sufficiently to allow at least partial weight bearing

Exclusion Criteria:

* Participants under the age of 18
* Participants unable to provide informed consent
* Participants with multiple pre-existing comorbidities that affect ability to participate in enhanced rehabilitation such as cognitive impairment, unstable angina.
* Central motor neurological impairment affecting ability to participate in an enhanced rehab programme
* Absence of functional disability affecting gait and / or function.
* Plans for further surgery that will impact on gait or function.