cyrilzakka/clinical-trials huggingface dataset:
Vouchers to Increase Uptake of Already Free Eye Care

This study was intended to test if reframing an offer for a free follow-up eye examination could increase uptake within ongoing community-based screening program for low-income and minority populations in Baltimore City. This study evaluated the effect of offering participants a physical voucher they were told was redeemable for free follow-up, relative to simply telling participants that the follow-up appointment would be free of charge. The investigators assessed two forms of vouchers, one with estimated value information, and one without. The underlying hypothesis was that reframing these already free offers would increase uptake by increasing perceived offer value and increasing a sense of regret from not taking advantage of a "good deal."


Eligibility Criteria:
Inclusion Criteria:

* Referred for follow-up at a Screening to Prevent Glaucoma (SToP) study screening event (overarching observational study from which trial sample was drawn). SToP participants were referred for follow-up for any of the following conditions: (1) VA worse than 20/40 in at least 1 eye despite autorefraction; (2) signs of retinal abnormalities on fundus photography; (3) uninterpretable fundus photography; (4) cup-to-disc ratio (CDR) greater than or equal to 0.9, and/or CDR between 0.7 and 0.9 with visual field defects or history of glaucoma; and (5) IOP of 23 mm Hg or greater.

Exclusion Criteria:

* SToP participants who were not referred at the time of screening but later contacted after review of fundus photography
* SToP participants who were referred for follow-up but stated at the time of counseling that they were already under the care of an eye doctor
The Colonoscopy Booklet:Effect of a Recipe Resource on Quality of Colonoscopy Bowel Preparation and Patient Experience

This study aimed to provide a recipe resource with visuals in line with the low-residue diet recommendations given to patients before colonoscopy, including cooking instructions for the meals in the diet list. In this way, we aimed to minimize confusion regarding dietary restrictions during colonoscopy preparation and ensure full compliance with the diet list. Our hypothesis is that this approach may enhance compliance with current recommendations and improve the quality of bowel preparation.

A total of 153 patients were included in this study. At the time of scheduling an outpatient colonoscopy, intervention group and control group were randomly assigned using a random-number generator for treatment allocation. The research protocol was explained during the colonoscopy appointment, and patients, when they agreed to follow their diet according to the recipe booklet, were accepted as part of the patient intervention group. A consent form was signed and collected. The nurse responsible for patient education in the endoscopy secretariat informed the patient that this booklet is an important component of bowel preparation and adhere strictly to the recipes in the booklet. The group who received the standard diet list and applied for their colonoscopy appointments were randomly designated as the control group. Bowel preparation was evaluated during the colonoscopy using the Boston Bowel Preparation Scale (BBPS). Cecal insertion and withdrawal times, polyp detection rate, utilization of the recipe resource, and patients' experiences related to colonoscopy were recorded.

The research team utilized freely available resources from general cookery recipe websites to create the recipe resource, adapting it to align with the recommendations for a low-residue diet (figure). Recipes were selected based on criteria such as being visually appealing, easy to prepare, and easily modifiable to comply with the low-residue diet. A dietitian examined the recipe resource to guarantee that the recipes followed low-residue diet guidelines.

Eligibility Criteria:
Inclusion Criteria:

- All outpatients who apply for a colonoscopy appointment.

Exclusion Criteria:

* Patients with a history of prior colonoscopic procedures
* Using anticholinergic or gastrointestinal motility-reducing drugs
* Severe chronic kidney failure (GFR\<30 ml/min)
* Advanced heart failure (NYHA III-IV)
* History of abdominal surgery were not included in the study.
Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate

The purpose of this study is to assess the effect of luteal phase supplement (LPS) on pregnancy rate in IUI cycles stimulated with clomiphene citrate.


Eligibility Criteria:
Inclusion Criteria:

* Age ≤ 36 years
* Body mass index between 18 and 29
* Presence of both ovaries
* Basal levels of estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle and a day three FSH level of \<12IU/L
* Patients can enter the study only once.
* Only the first IUI attempt will be included ( at the 2nd and 3 rd attempt progesterone could be administrated if it is necessary but these attempts will be excluded from the study)
* Normal HSG (maximum 3 months prior starting the stimulation).
* Donor sperm can be included

Exclusion Criteria:

* Polycystic ovarian syndrome (Rotterdam criteria)
* Endometriosis(≥AFS III)
Physical Activity in Children With Inherited Cardiac Diseases

Use lay language.

Current guidelines regarding physical activity in patients with inherited arrhythmia and cardiomyopathy are mostly dedicated to adult patients, with a special focus on sports competition. Their application to the pediatric population has been scarcely evaluated.

Physical activity is well known for its health benefits but may be dangerous in this population, which leads to confusion within the medical community and among patients. Actual physical activity of children with such inherited cardiac disorders is unknown.

This study aimed to assess the level of physical activity in children with inherited arrhythmia and cardiomyopathy, and the adherence to the current European guidelines on the subject. Secondary objectives aimed to assess through a qualitative analysis the impact of the disease on physical activity and daily life in this population.

The level of physical activity and adherence to current guidelines will be determined from interviews between the patient and the principal investigator. Each patient will be questioned in order to explore the experiences, motivations and feelings of participants regarding physical activity. The standardized questionnaire was created by the principal investigator and members of the clinical research team.

The investigators believe that many children practice physical activity outside the current guidelines and hope to identify the main determinants of physical activity in this population.


Eligibility Criteria:
Inclusion criteria:

Children from 6 to 18 years old with clinical and/or genetic diagnosis of :

* Long QT syndrome
* Brugada syndrome
* Catecholaminergic polymorphic ventricular tachycardia
* Hypertrophic cardiomyopathy
* Dilated cardiomyopathy
* Arrythmogenic right ventricular cardiomyopathy

Exclusion criteria:

* Presence of extra cardiac co-morbidity with motor or psychological repercussions hingering physical activity
* Refusal from children or parent to participate in the study
Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis.

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis. The purpose of the study is to determine if intra-articular steroids suppress markers of bone formation or resorption in osteoarthritis patients and whether these markers may be modified by Vitamin D or Dual-energy X-ray absorptiometry (DEXA) bone density status

Eligibility Criteria:
Inclusion Criteria:

* Age \> 40 years
* Male or postmenopausal female
* Diagnosis of knee osteoarthritis
* DEXA bone density done within the past 12 months
* Painful knee, visual analogue scale (VAS) \> 4 of (10=worst)

Exclusion Criteria:

* Diabetes Mellitus Type I or II
* Systemic inflammatory illness
* Systemic infections which may be aggravated by steroid therapy
* No current or previous (\< 3 years) biphosphate therapy
* Previous knee replacement surgery
* No current or previous Parathyroid hormone (PTH) therapy
Comparison of Nasal Taper-guard Cuffed and a Nasal Cylindrical Endotracheal Tube

This study was designed to evaluate the effect of change of head position on the cuff pressure of TaperGaurd endotracheal tube , compared to cylindrical endotracheal tube during oral surgery.

The patient in cylindrical group (n=26) were intubated with cylindrical shaped endotracheal tube (Unomedical, Kedah, Malaysia) and the patient in tapergaurd group (n=26) was intubated with TaperGuard endotracheal tube (Covidien, Athlone, Ireland). The group allocations were informed to the attending anesthesiologist prior to anesthesia. Tracheal intubation was performed with size of inner diameter 7.0 mm endotracheal tube for male and 6.5 mm endotracheal tube for female by the same anesthesiologist. The anesthesiologist measured cuff pressure and distance from endotracheal tube tip to carina during study period.This study was designed to evaluate the effect of change of head position on the cuff pressure of TaperGaurd endotracheal tube, compared to cylindrical endotracheal tube during oral surgery.

Eligibility Criteria:
Inclusion Criteria:

* Patient who were underwent nasal intubation

Exclusion Criteria:

* history of difficult intubation, limited neck movement, respiratory diseases and body mass index more than 35 kg/m2
Investigations of Ear Tip Performance, Perceptions, and Experiences

Normal hearing participants will be fit with a hearing aid and different types of customized earmolds. Hearing aids will be programmed to a simulated mild, flat, sensorineural hearing loss of 30 dB HL from 250-8000Hz. Objective acoustic real ear measures and subjective ratings of sound quality and physical comfort will be evaluated and compared between earmolds. Findings will help researchers to better understand the impacts of different earmolds and how each might affect overall point-of-care.


Eligibility Criteria:
Inclusion Criteria:

* Normal hearing thresholds (\<25 dB HL) at octave frequencies from 250-8000Hz.
* Normal otoscopy: patent ear canals with normal appearing eardrums and aerated middle ear, bilaterally.
* English as primary spoken language.

Exclusion Criteria:

* history of extensive or current outer or middle ear pathology.
* history of extensive outer or middle ear surgery.
* history of neurological or cognitive disorder.
Impact of Containment and the Current Epidemic on the Sexual Risk-taking of People Using PrEP to Prevent HIV Infection.

People using PrEP to prevent HIV infection have sexual risk-taking behaviors that motivated the prescription of PrEP. Both containment and the current epidemic may affect the sexual behavior of people using PrEP and the risk of acquiring STIs.

Hypotheses regarding the impact of the current epidemic-motivated confinement and its gradual lifting are as follows:

* A decrease in sexual risk-taking during the confinement period, followed by an increase when the confinement is lifted.
* An increase in sexual violence and the use of psychoactive substances.
* An impact on PrEP monitoring and compliance.
* An increase in the incidence of STIs when the confinement is lifted.


Eligibility Criteria:
Inclusion Criteria:

* People using PrEP for HIV prevention being followed up at Tourcoing hospital
* Having given their consent to participate in this study
* Beneficiary of a social insurance plan or entitled person

Exclusion Criteria:

* Minor patient
* Refusal to participate
* Trusteeship
* Curatorship
Fenofibrate and Pharmacogenetic Impact in Dyslipidemia

The purpose of the study is to learn whether genetics plays a role in predicting response to a commonly used and FDA (Food and Drug Administration) approved medication for lowering triglycerides and cholesterol. The hypothesis: The pharmacogenetics of genes which affect drug metabolism (how the body handles the drug) and drug targets (how the drug acts on the body) influences how a person responds to the lipid lowering medication-fenofibrate.

The investigators seek to screen over 200 subjects for select candidate genes to serve as a source of subjects which may participate in a genotype guided investigation as to the predictability of response based on genotype. Response endpoints relate to lipid parameters and other variables of interest to cardiovascular endpoints. Subjects with genotypes of interest would then be enrolled into a short term clinical trial evaluating their response to fenofibrate based on their genetic profile ascertained from the screening phase.

Eligibility Criteria:
Inclusion Criteria:

* 18-75 year old
* Be willing to participate in the study and attend the scheduled clinic exams
* Consent to taking lipid lowering therapy for 4 weeks and if necessary discontinue lipid lowering agents for a period of 8 weeks

Exclusion Criteria:

* \<18 years of age
* History of liver, kidney, pancreas, pancreatitis, gall bladder disease or malabsorption (Crohn's disease etc.)
* Use of insulin or currently taking warfarin
* Pregnant women or women of childbearing potential not using an acceptable form of contraception
* History of an allergy or hypersensitivity to fenofibrate
* Investigational drug use within 30 days of the study
* A disease that, in the opinion, of the PI, would put the subject at risk during the study
Oral Health Promotion Strategy for Persons With Intellectual/Developmental Disabilities

A Phase II cluster randomized controlled trial of the (OHPROM) strategy/intervention will be conducted in partnership with several organizations that provide residential services for persons with intellectual developmental disabilities (IDD) in north central Kentucky and southern Indiana. The investigators have identified a purposive sample of group homes, caregivers, and persons with IDD and have the support of these organizations.

The proposed intervention is comprised of four components : (a) planned action including a behavioral contract Activity 1) with caregivers and action planning for oral health (Activity 2), (b) caregiver capacity building with didactic training (Activity 3), observational learning and caregiver practice (Activity 4); (c) environmental adaptations with location of oral health activities and reminder posters - physical environment (Activity 5) and administrative oral health support- (social environment (Activity 6); and (d) reinforcement with caregiver coaching (Activity 7).

Eligibility Criteria:
Inclusion Criteria:

* Persons with IDD: To be eligible to participate in this study, an individual must meet all of the following criteria:

  * Be a resident in a group or family home associated with one of the six partner organizations participating in this study
  * Provide signed and dated informed consent form, to be signed by self or a legally authorized representative (LAR), if one has been appointed
  * Be willing and able to comply with all study procedures and expect to be available for the duration of the study
  * Be aged 18 to 75
  * Have at least six teeth
  * Have diagnosis of mild, moderate, severe, or profound intellectual and/or developmental disability

Caregiver staff: To be eligible to participate in this study, caregiver staff must meet all of the following criteria:

* Work as a direct care staff member in a group/family home
* Provide signed and dated informed consent form
* Be willing to comply with all study procedures and be available for the duration of the study
* Be aged 18 to 75

Exclusion Criteria:

* Persons with IDD: Will be excluded (screen failure) if they are unable to cooperate or refuse the oral examination.
* Caregivers: There are no exclusions.
Prospective rAndomized sTudy efficaCy tHree-dimensional rEconstructions Segmentectomy

With this project we want to study the effectiveness of 3D reconstruction of preoperative CT to reduce operating times, blood loss and conversions after segmentectomy performed in thoracoscopy / robotics.

Pulmonary segmentectomy is the surgery of first choice in malignant lung tumors with a diameter \<2 cm in diameter. Patients who are candidates for this type of treatment perform usually a preoperative CT scan with two-dimensional reconstructions (2D: axial, coronary and sagittal). Today it is possible to perform a preoperative three-dimensional reconstruction (3D: volume rendering) of the vessels and bronchi using special software.

Objectives of the study is to analyze, in these patients, the benefits of 3D reconstruction of vessels and bronchi compared to 2D reconstruction, analyzing intra- and post-operative data.The study aims to randomize 288 patients over 36 months.

Study design: Prospective, randomized, controlled study. In 50% of patients the preoperative study of anatomical structures will be performed with the standard 2D method, in the remaining 50% with a 2D and 3D reconstruction. The assignment will take place through access to an online feature on the study website.

Evaluations and statistical methods The statistical analysis will be carried out using parametric and nonparametric descriptive, inferential statistical methods, while the main outcome will be carried out using the analysis of variance (ANOVA) and covariance (ANCOVA) techniques.

Ethical aspects. The study will be conducted in accordance with applicable current legislation. Approval by all relevant ethics committees will be required. Each patient will provide a written consent to participate in the study, after being properly informed.

Eligibility Criteria:
Inclusion Criteria:

* Segmentectomy performed through a minimally invasive approach (VATS or RATS).
* Pathologically proven NSCLC on the resected specimen.
* Age ≥18
* Signed written informed consent

Exclusion Criteria:

* Prior homolateral cardiothoracic surgery.
* Allergy or any other contraindication to iodinated contrast media.
* Segmentectomy performed through an open approach (thoracotomy)
* Histology different than NSCLC.
* Pregnancy
Patient Experience Following Awake Fibreoptic Intubation Compared to Asleep Fibreoptic Intubation

The aim of this observational study is to explore and compare patients' experiences of asleep and awake fibreoptic intubation using a semi qualitative patient questionnaire. In particular, investigators will investigate the occurrence of negative experiences, such as distress and discomfort.

This study aims to investigate whether there are significant differences in aspects of patient experience during AFOI and asleep fibreoptic intubation. The study will be conducted at University Hospitals Coventry and Warwickshire NHS Trust and Oxford University Hospitals Foundation Trust.

Investigators are not aware of any studies to date comparing patient experiences of AFOI with asleep fibreoptic intubation to ascertain the significant differences in side effects. If there is no evidence of any significant difference in negative patient experiences, this might help to encourage anaesthetists to reduce their threshold for AFOI and to use this as first choice for anticipated difficult airway management.

A member of the research team will approach the patient about the study and obtain written informed consent, if the patient is willing and able to participate. The participant will be provided with a specifically designed questionnaire, covering several aspects of patient experience. A mixture of free response answers and numerical rating scales will be used. The member of the research team approaching the patient with the questionnaire will be blinded to the intubation procedure, ensuring consistent application of the questionnaire and minimising bias. This will then be the end of the study for the participant.

Eligibility Criteria:
Inclusion Criteria:

* All patients aged 18 years and above
* Patients who underwent head and neck or dental surgery and required awake or asleep fibreoptic intubation
* Patients who underwent elective surgery
* Are able and willing to provide written informed consent

Exclusion Criteria:

* Patients who do not consent to be part of the study
* Patients below 18 years old If a translator is not available at the time, participants who cannot reasonably read and communicate in English
* Those who did not undergo awake or asleep fibreoptic intubation
* Those who underwent emergency surgery
Surgeon-Guided Serratus Block in Breast Reduction Surgery

Surgeon guided serratus block, which can be performed by the surgeon in participants undergoing breast reduction surgery, may reduce the sensation of pain from the surgical field in the postoperative period. Thus, participants experience less pain in the postoperative period, consume less analgesics, and there is a decrease in related complications. The aim of this study was to evaluate the effects of the intraoperative surgeon guided serratus block applied on the analgesic consumption of the participants in the first 24 hours after surgery in participants undergoing breast reduction surgery.


Eligibility Criteria:
Inclusion Criteria:

* Patient's willingness to be included in the study
* 18-65 years
* Woman
* Operated with inferior pedicled breast reduction technique
* The distance from the sternal notch to the nipple complex is between 25-40cm
* ASA I-II
* Breast Usg result BIRADS 1-2
* Patients who have not previously received RT to the breast and have no history of malignancy

Exclusion Criteria:

* Patient's request/refusal not to be included in the study
* Previous history of malignancy
* RT story,
* ASA 3-4-5-patient group
* Severe organ failure
* Alcohol, drug addiction
* Bupivacaine allergy
* Diagnosis of psychiatric illness and psychiatric drug use
* Surgery lasting longer than 3 hours
* Bleeding diathesis
Procedure Selection in Obesity and Metabolic Surgery Based on EOSS

The Edmonton Obesity Staging System (EOSS) is a more comprehensive measure of obesity-related diseases and predictor of mortality than BMI or waist circumference. EOSS is also important in predicting post - operative outcome and 30-day mortality after metabolic surgery.

The aim of this study is to determine whether EOSS could be an indicator for procedure selection in obesity and metabolic surgery.

All patients in Germany, who underwent Sleeve Gastrectomy, Roux-en Y Gastric Bypass and Mini/One anastomosis Gastric Bypass as a primary procedure for severe obesity, are prospectively registered in the German register StuDoQ MBE.

Preoperative EOSS by Sharma et al. will be applied to all patients, who were operated between Februar 2015 and July 2017 by two different evaluators. Data collection will include the following: gender, age, body mass index, mobility, comorbidities, ASA score (American Society of Anesthesiologists score) perioperative complications next to Clavien Dindo, readmission rates and 30 - day mortality. Follow-up will be investigated in all patients up to 1 month after surgery.

Complications, readmission rates and 30 day mortality will be investigated in relation to EOSS and the surgical procedure performed, to determine whether EOSS could be an indicator for procedure selection in obesity and metabolic surgery.

Eligibility Criteria:
Inclusion Criteria:

Sleeve for severe obesity RNYGB for severe obesity MGB/OAGB for severe obesity

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Exclusion Criteria:

* previous obesity surgery
* previous surgery of the upper gastrointestinal tract in anamnesis