cyrilzakka/clinical-trials huggingface dataset:
Cancer Diagnosis by Multiparametric UltraSound of the Prostate

In men who require a prostate biopsy does a multi-parametric ultrasound based diagnostic strategy compared to a multi-parametric MRI based diagnostic strategy lead to similar detection of clinically significant prostate cancer?

Men who require prostate biopsy will be approached and consented to enter this study. Participants will all undergo pre-biopsy mp-MRI and mp-USS of the prostate. Only men with positive scans will undergo prostate biopsy. The order in which lesions discovered on mp-MRI or on mp-USS are sampled will be randomised. All biopsies will be taken via the transperineal route in a single procedure. Comparison will be drawn between biopsy results of lesions detected by mp-USS with those lesions detected by mp-MRI. Consideration will be given as to whether a lesion detected by one imaging modality is the same abnormality as one detected by the other imaging modality, in the same patient. Analysis will be carried out at both the level of the lesion and the whole prostate. Men without suspicious lesions on either imaging modality will not proceed to biopsy.

Eligibility Criteria:
Inclusion Criteria:

1. A potential need for prostate biopsy indicated by raised PSA or other clinical parameter, the final decision over which will be taken after imaging.
2. PSA \</=20ng/ml measured within 6 months of screening visit
3. An understanding of the English language sufficient to understand written and verbal information about the trial and consent process
4. Estimated life expectancy of 5 years or more
5. Signed informed consent

Exclusion Criteria:

1. Any contraindication to the ultrasound contrast agent including right to left shunt, pulmonary hypertension, uncontrolled hypertension and adult respiratory distress syndrome. Also patients with a recent acute coronary syndrome or unstable ischaemic heart disease.
2. Any form of hormones (except 5-alpha reductase inhibitors) within 6 months of screening visit
3. Irreversible coagulopathy predisposing to bleeding
4. Inability to undergo transrectal ultrasonography
5. Prostate volume, measured at the time of mp-USS if previously unknown, of \>60cc.
6. Previous radiation therapy to the prostate
7. Previous HIFU, cryosurgery, thermal therapy, irreversible electroporation, photodynamic, photothermal therapy, microwave or injectable toxin therapy to the prostate.
8. Transurethral resection or vaporization of the prostate for benign prostatic hyperplasia using any energy modality within 6 months of screening visit
9. Nodal or metastatic prostate cancer on any form of imaging at any time-point
10. Not fit for general anaesthetic
11. Any other condition the investigator considers would make the patient unsuitable
Testing "Ultraprocessed" Front-of-package Label Among Brazilian Consumers

The goal of this experiment is to test the effects an "ultraprocessed" warning label on foods and beverages among Brazilian consumers. The main questions it aims to answer are:

* Do "ultraprocessed" warnings affect Brazilian consumers' intention to purchase products?
* Do "ultraprocessed" warnings affect Brazilian consumers' product perceptions?

Participants will see images of four products carrying either nutrient warning labels (which are currently mandatory in Brazil) or nutrient warning labels alongside an experimental warning label informing that the product is ultraprocessed. Participants will then answer survey questions about each product. Researchers will compare responses between both arms to determine if the "ultraprocessed" warning significantly changes the effect of nutrient warnings.


Eligibility Criteria:
Inclusion criteria:

* 18 years or older,
* residing in Brazil,
* responsible for at least 50% of the household's grocery purchases.

Exclusion criteria:

* involvement in any pre-testing.
Enhancing Prospective Thinking in Early Recovery (PARK)

The goal of this clinical trial is to demonstrate the commercial potential for a novel virtual reality (VR) intervention in preparation for Phase II development. This clinical trial will test the VR intervention for efficacy in reducing opioid use, increasing abstinence, and other self-reported and behavioral focus on future outcomes in individuals in early recovery from opioid use disorder.

* Will the VR group, compared to the control group, have a lower number of opioid use days?
* Will the VR group, compared to the control group, have longer periods of abstinence at the 30-day follow-up?
* Will the VR group, compared to the control group, have significantly increased opioid abstinence rates?
* Will the VR group, compared to baseline and the control group, show increased future self-identification post-VR intervention?
* Will the VR group, compared to baseline and the control group, show increased future orientation post-VR intervention?
* Will the VR group, compared to baseline and the control group, show an increased preference for delayed rewards in a laboratory delay discounting task post-VR intervention?
* Will the VR group, compared to baseline and the control group, exceed in behavioral effects (i.e., future self-identification, future orientation, and increased preference for delayed rewards) at the 30-day follow-up?

Researchers will compare the VR test group and the control group to see if there are differences in the results for the questions outlined above.


Eligibility Criteria:
Inclusion Criteria:

* Abstinence between ≥14 days and ≤ 1 year
* 18-60 years old
* Verbal endorsement of commitment to recovery
* Outpatient
* Psychotropic drugs for SUD-comorbidity
* Mu-Opioid drugs
* Drug/alcohol abstinence ≥ 24 hours at the time of the study day visit
* English comprehension

Exclusion Criteria:

* Unstable medical disorders
* Outside the age range of 18-60
* Habitual drug use
* Smell/taste disorders
* Unstable psychiatric conditions
* Extravagant/elaborate face tattoos
The Protection of ACD III on Erythrocytes in Intraoperative Blood Salvage During Cardiopulmonary Bypass

To evaluate the effects of blood preservation solution III (sodium citrate, sodium dihydrogen phosphate, sodium citrate, glucose and adenine) in autologous blood recovery and storage bags on the metabolic morphological functions and characteristics of red blood cells in patients undergoing cardiac surgery supported by cardiopulmonary bypass

Blood preservation solution III is a blood protective solution clinically used to store whole blood and red blood cells. It is a sterilized aqueous solution composed of sodium citrate dihydrogen phosphate sodium citrate glucose and adenine, in which glucose adenine can provide the required energy for stored RBC. Citric acid/sodium citrate buffer pair can adjust the pH of RBC suspension; Sodium dihydrogen phosphate can prevent RBC aggregation, provide phosphate for RBC energy metabolism, and slow down the decline rate of 2,3-DPG. Blood preservation solution III can reduce RBC destruction and protect its function. Therefore, this study aims to explore the effect of adding blood preservation solution III in blood storage bags on CPB Influence of autologous blood recovery RBC during cardiac surgery.

Eligibility Criteria:
Inclusion Criteria:

Elective median incision for cardiac surgery under CPB ASAⅠ\~Ⅲ Intraoperative blood recovery is pollution-free No blood system diseases, no red blood cell related diseases Preoperative blood routine examination showed no obvious abnormalities in blood coagulation function and biochemistry

Exclusion Criteria:

* Patients have malignant tumor Patients are complicated with systemic infectious disease Intraoperative blood loss is expected to be less than 200ml Patients receiving allogeneic red blood cells during operation
Qualitative Study on Factors Impeding Physical Activity During the Post-discharge Period After Hematopoietic Stem Cell Transplantation in Children

The purpose is to gain a deep understanding of the hindering factors in physical activities during the home period after pediatric hematopoietic stem cell transplantation, in order to provide references for developing targeted intervention measures.

From October 2023 to September 2024, a purposive sampling method will be used to select 10 post-pediatric hematopoietic stem cell transplant patients and 10 family members receiving treatment at Sun Yat-sen Memorial Hospital, Zhongshan University, as the subjects for the study. The phenomenological approach in qualitative research will be employed to conduct in-depth interviews with them, and data analysis will be performed using the Colaizzi analysis method.

Eligibility Criteria:
Inclusion Criteria:

* The child's age ranges from 8 to 18 years old.
* They have undergone hematopoietic stem cell transplantation for at least one month.
* They do not have any mental disorders or consciousness impairments.
* The child is capable of independent walking.
* The interviewees are able to express their thoughts clearly.
* Both the child and their family members are informed about and have given consent to participate in this study.

Exclusion Criteria:

* Relapse or the presence of other tumors
* Physical activity prohibitions, such as movement disorders, platelet count \<20×10⁹, -acute bleeding, hemoglobin level \<80g/L
* Fever with a temperature of 38.8℃ or higher due to infection
* Pain score of 4 or higher
* Other severe complications, such as heart failure or severe malnutrition.
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure

Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical ventilation strategy, reduce ventilator-associated lung injury and improve outcomes. The objective of the study is to evaluate the respiratory mechanics, lung recruitability and gas exchange in COVID-19 -associated acute respiratory failure during the whole course of mechanical ventilation - invasive or non-invasive.

In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. The World Health Organization (WHO) declared the outbreak a pandemic on March 11th, 2020. The clinical disease (COVID-19) results in critical illness in about 5% of patients with predominant acute respiratory failure.

The goal of the study is the evaluation of the respiratory mechanics (peak inspiratory pressure (PIP), plateau pressure (Pplat), static compliance (Cstat), driving pressure (DP) at different positive end-expiratory pressure (PEEP) levels and different tidal volumes (Vt) (6-8 ml/kg ideal body weight), lung recruitability (by change of DP and oxygenation) and gas exchange (PaO2/FiO2 ratio and alveolar dead space) in COVID-19 -associated acute respiratory failure during the whole course of mechanical ventilation - invasive or non-invasive for selection of safe and effective PEEP level, Vt, respiratory rate (RR) and inspiratory oxygen fraction (FiO2) during the whole course of mechanical ventilation - invasive or non-invasive.

This study is multicentral observational trial in 3 University clinics.

Eligibility Criteria:
Inclusion Criteria:

* all patients with COVID-19 and acute respiratory failure on invasive and noninvasive ventilation

Exclusion Criteria:

* Patients who reached the following goals at conventional oxygen therapy (oxygen flow \< 15 l/min): peripheral capillary oxygen saturation(SpO2) \> 93%, no visible work of auxiliary respiratory muscles, no fatigue, stable hemodynamics (no need in any catecholamines and/or life-threatening heart rhythm abnormalities),
* less than 24 ours in intensive care unit (ICU) by any reason,
* lung emphysema,
* primary lung diseases (chronic obstructive lung disease-COPD, interstitial lung diseases, etc) or tumour metastases in lungs,
* chronic decompensated diseases with extrapulmonary organ dysfunction (tumour progression, liver cirrhosis, congestive heart failure),
* atonic coma.
Abnormal Pain Processing in COPD Patients

Dyspnea, cough, and fatigue are the symptoms characteristic of moderate-severe COPD. Within the progression of disease was also reported a prevalence of 34-77% of pain symptoms in these patients. A review observed a higher score in pain intensity/interference associated with multiples pain locations of COPD patients. Pain in chronic diseases may appear to result from abnormalities in pain processing because of the damage and/or inflammation of peripheral structures.

Dyspnea, cough, and fatigue are the symptoms characteristic of moderate-severe COPD. Within the progression of disease was also reported a prevalence of 34-77% of pain symptoms in these patients. A review observed a higher score in pain intensity/interference associated with multiples pain locations of COPD patients. Several studies reported that comorbidities, GOLD grade, and breathlessness may contribute to a higher pain prevalence in COPD patients because of the systemic inflammatory process and lung hyperinflation. Pain in chronic diseases may appear to result from abnormalities in pain processing and alteration of sensitization due to the damage and/or inflammation of peripheral structures.

Eligibility Criteria:
Inclusion Criteria:

* Between 50 and older age
* Accepted to sign the informed consent

Exclusion Criteria:

* comorbidities with a course of chronic pain that interfered with evaluation
* the presence of cognitive impairment to understand the questionnaire
Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo

Western University of Health Sciences is seeking men and women to participate in a study on the effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in patients with vertigo. The purpose of this study is to examine the efficacy of OMT in the treatment of individuals with vertigo, alone and in combination with Vestibular Rehabilitation Therapy (VRT). Because of the health care costs associated with vertigo, the cost effectiveness of OMT and VRT will also be examined.


Eligibility Criteria:
Inclusion Criteria:

* Symptoms of dizziness or a diagnosis of vertigo for longer than 3 months duration
* Able to tolerate 30 minutes of sitting and standing
* Able to transfer from sitting to standing and move independently
* Able tolerate manual therapy and exercise

Exclusion Criteria:

* Severe traumatic injury
* Bleeding disorders and anticoagulation (Coumadin) therapy
* Currently receiving VRT, vision therapy, or manual medicine (OMT, Chiropractic, etc.) or received manual medicine within the past three months
* Down syndrome
* Ehlers-Danlos syndrome
* Endolymphatic Hydrops
* Legal blindness in one or both eyes
* Menieres disease
* Neurological conditions (including Peripheral Neuropathy, Stroke, traumatic brain injury, cerebral aneurysm, and Multiple Sclerosis)
* Rheumatoid Arthritis
* Spinal trauma or history of cervical spine surgery
Assessment of Pulmonary Congestion During Cardiac Hemodynamic Stress Testing

The aim of this study is to utilize lung ultrasound to detect the development of extravascular lung water in patients undergoing clinically indicated invasive hemodynamic exercise stress testing for symptomatic shortness of breath. The study will correlate the lung ultrasound findings with cardiac hemodynamics and measurements of extravascular lung water in an effort to better understand the pathophysiology of exertional dyspnea.

Exercise induced elevation of left ventricular (LV) filling pressures can be the source of chronic dyspnea. Ultimately, high LV filling pressure leads to the development of extravascular lung water (EVLW) which can cause symptoms of dyspnea. Lung ultrasound (LUS) is a highly feasible, non-invasive procedure that is extremely sensitive for detecting EVLW. The sonographic signature of EVLW is a reverberation artifact called a "B-Line". The study will evaluate the etiology of sonographic B-Lines using invasive hemodynamic catheterization while simultaneously measuring the amount of EVLW present during exercise stress testing using transpulmonary thermodilution. The study aim is to demonstrate that the severity of EVLW, assessed by number of B-Lines, will correlate with LV filling pressures. In addition, the study will test the hypothesis that patients demonstrating dynamic increases in sonographic B-Lines with exercise will also display more severe symptoms of dyspnea, altered ventilatory mechanics (higher ratio of minute ventilation to carbon dioxide production (VE/VCO2)), and reduced aerobic capacity (lower peak oxygen consumption (VO2)).

Eligibility Criteria:
Inclusion Criteria:

* All adult patients (≥18 years) who are referred for invasive cardiac hemodynamic assessment
* Patients who have the capacity to understand and consent for the research study

Exclusion Criteria:

* Patients with known interstitial lung disease or pulmonary fibrosis
Pharmacotherapy of Treatment-Resistant Mania

Verapamil has been found in some but not all studies to have antimanic activity. Therefore, we investigated the use of verapamil, alone or as an adjunctive treatment, in manic patients who did not respond to an initial adequate trial of lithium. Each study phase lasted three weeks. Subjects were treated openly with lithium in Phase 1 (n=45). Those who failed to respond were randomly assigned to double-blind treatment in Phase 2 with either verapamil (n=10) or continued lithium (n=8). Phase 2 responders were continued on the same medication in Phase 3. Phase 2 nonresponders (n=10) were assigned to combined verapamil/lithium in Phase 3.


Eligibility Criteria:
Inclusion Criteria:

* To be eligible for the study, patients were required to have a lifetime diagnosis of bipolar 1 or schizoaffective disorder, a current manic episode meeting DSM-IV criteria, and ratings \>/= 7 on the Raskin Severity of Mania Scale and \>/= 15 on the Bech-Rafaelsen Mania Scale.

Exclusion Criteria:

Patients were excluded if they had:

* A pattern of severe rapid-cycling in which the patient consistently failed to meet the duration criteria for discreet episodes of syndromal mania or depression according to DSM-IV
* Sustained drug or alcohol abuse within the past three years
* Schizophrenia
* Organic affective syndrome
* A presenting episode that was secondary to the effect of any pharmacologic agent
* The presence of significant medical illness that would preclude or unduly complicate the intended pharmacologic management of the episode
* In females, refusal to use appropriate contraception; or
* Pregnancy.
Effect of Exercises on Forward Head Posture

The Study aims to evaluate the effectiveness of chin tuck exercises in improving forward head posture.

To assess the impact of cervical extension exercises on forward head posture. To determine which exercise protocol provides superior results for FHP

The study focus on understanding Forward head posture (FHP). Forward head posture (FHP) is a common musculoskeletal disorder characterized by a shift of the head forward in relation to the vertical axis of the body. This condition increases the load on the cervical spine, causing discomfort, pain and impaired musculoskeletal function. The incidence of FHP has increased significantly due to sedentary lifestyles and prolonged use of electronic devices, making it a pressing problem for healthcare providers.

Eligibility Criteria:
Inclusion Criteria:

* Participants falling in this category would be recruited into the study.
* Adults aged 30-45 years with diagnosed forward head posture.
* Chronic nonspecific neck pain for at least 3 months.
* FHP diagnosed via craniovertebral angle measurement.

Exclusion Criteria:

* Participants fall in this category would be excluded of the study.
* History of cervical spine surgery or trauma.
* Severe cervical instability or neurological deficits.
* Systemic diseases affecting posture.
Functional Recovery of Patients Undergoing Resection and Reconstruction of the Lower Limbs for Bone Tumor.

The aim of the present study is to describe the course of functional recovery of patients with musculoskeletal tumours and undergone resection and reconstruction operations of lower limbs in the first six months post-surgery, differentiating them on the basis of the anatomical level involved.

Retrospective observational study will be conducted. The evaluation of the patients clinical recovery progress will take place at three different times: during the hospital stay postoperative, at 3 and 6 months after surgery. Different outcome measures will be considered in order to provide a complete picture of the patients functional recovery and their change.

Eligibility Criteria:
Inclusion Criteria:

* All participants undergone lower limb resection and reconstruction with localisation of the disease to the pelvis, femur femur, tibia and foot bones.
* All participants undergone soft tissue resection surgery on the of the lower limb
* All types of oncological diagnoses will be taken considered: osteosarcoma, Ewing and others.

Exclusion Criteria:

* Participants who undergo at our Institute only the surgical treatment while continuing adjuvant treatment at other centres
* Participants for whom no rehabilitation treatment has been activated during adjuvant treatment at our Institute
The Effect of Pudendal Blocks on Voiding Dysfunction Following Slings

To determine the effect of a bilateral pudendal block on voiding dysfunction following midurethral slings.

Midurethral slings (MUS) are commonly performed to treat stress urinary incontinence in women. One common complication is short-term postoperative voiding dysfunction. Approximately 20% of patients undergoing MUS have difficulty voiding in the immediate postoperative period and are discharged home with an indwelling bladder catheter. A pudendal block provides analgesia to the vulva, vagina, and perineum and is used in various fields, ranging from obstetrical indications to hemorrhoidectomies. The colorectal literature has demonstrated an improvement in postoperative voiding dysfunction with intraoperative bilateral pudendal blockade, presumably due to pain relief. However, only one study has explored the effect of a pudendal blockade on postoperative voiding in patients undergoing MUS. This was a small French case series of 9 patients, and it concluded that it was a safe procedure with good patient satisfaction. Given the scant literature evaluating voiding dysfunction following pudendal blocks in MUS, and the encouraging data from anorectal surgeries, we aim to study this effect via a randomized, placebo-controlled, double-blinded trial.

Eligibility Criteria:
Inclusion Criteria:

* Women undergoing a midurethral sling without concomitant procedures under general anesthesia

Exclusion Criteria:

* Unable to consent (lacking capacity)
* Under 18 years of age
* Pregnant women
* Prisoners
* Using intermittent self-catheterization preoperatively
* Neurological disease or spinal cord injury resulting in voiding dysfunction
* Allergy to bupivacaine
* Diagnosis of chronic pain syndromes
* Daily use of narcotics
* Intra-operative bladder injury necessitating use of a prolonged indwelling Foley catheter
Conversations You Want About Corona Virus Disease (COVID-19)

Web-enabled virtual topical guide: develop virtual conversations for each concern and intensity level

Study will pilot test the virtual topical discussion guide with diverse health care professions and community members to confirm it is clear, relevant, understandable, and culturally appropriate

Eligibility Criteria:
Inclusion Criteria:

* greater than or equal to 18 years of age
* English or Spanish speaking only

Exclusion Criteria:

* less than 18 years of age
* not English or Spanish speaking