cyrilzakka/clinical-trials huggingface dataset:
Lifestyle Scenario Demonstration on Dialysis Modality

Based on real cases, daily life scenarios of peritoneal dialysis and hemodialysis patients were shooted and edited into video films, including environment of home dialysis, dietary patterns, water intake, sports mode, daily work, short time of travel and other activities, covering a certain natural day of either peritoneal or hemodialysis and some important time points in the way of life, such as nursing and treatment for common complications of the corresponding dialysis mode. The videos will also show the advantages and disadvantages of the two modes of dialysis. According to their actual living conditions, patients will decide the right dialysis modality that suite them well, thus improving dialysis compliance and psychological adaptability.

Based on real cases, daily life scenarios of peritoneal dialysis and hemodialysis patients were shooted and edited into video films, including environment of home dialysis, dietary patterns, water intake, sports mode, daily work, short time of travel and other activities, covering a certain natural day of either peritoneal or hemodialysis and some important time points in the way of life, such as nursing and treatment for common complications of the corresponding dialysis mode. The videos will also show the advantages and disadvantages of the two modes of dialysis. According to their actual living conditions, patients will decide the right dialysis modality that suite them well, thus improving dialysis compliance and psychological adaptability.

By "informed decision score" questionnaire, comparison of two groups of patients on dialysis awareness of the pattern and ratio of patients choosing hemodialysis and peritoneal dialysis were performed. Dialysis mode conversion rates of the two groups were finally calculated and the correlation between awareness of dialysis modality and conversion rates of dialysis methods was analyzed.

Eligibility Criteria:
Inclusion Criteria:

* CKD（chronic kidney disease） stage 5 patients with replacement therapy indications, age≥ 18 years, ≤70 years
* without any contraindications of peritoneal dialysis or hemodialysis

Exclusion Criteria:

* Age\> 70 years or \<18 years old
* contraindications of peritoneal dialysis or hemodialysis
* Patients who cannot be followed well after dialysis.
Compliance With Antibiotic Treatment in General Practice

The guidelines of The Norwegian authorities concerning the use of antibiotics in general practice state that for several common diseases such as pneumonia and tonsillitis, antibiotics should be given four times daily instead of three times daily. The study´s aim is to see whether the patient compliance is significantly reduced in antibiotic regimes of 3 or 4 daily doses as compared to 1 or 2 daily doses.

All patients given antibiotic tablets, independent of diagnosis and medicament, are included. All patients give a written consent. Within a week after the end of the treatment all patients are contacted by one of the authors and asked a few standardized questions concerning their compliance with the treatment.

Eligibility Criteria:
Inclusion Criteria:

* Any patient given antibiotics for any cause

Exclusion Criteria:

* Use of mixture instead of tablets
* Tablets administrated by public health care services
Feasibility and Acceptability Study of ACUAWARE

This study aims to gather preliminary feasibility and acceptability data to justify a subsequent trial that would fill a gap in knowledge regarding acupuncture therapy (AT) effects on interoceptive awareness (IA) among those with chronic pain.

This study aims to gather preliminary feasibility and acceptability data to justify a subsequent trial that would fill a gap in knowledge regarding acupuncture's effects on interoceptive awareness among individuals with chronic pain. Our primary hypotheses are that (1) Feasibility: it is feasible for us to enroll and retain 70% of the patients and it is feasible to collect data from at least 70% of participants at 3-months follow-up, and (2) Acceptability: it is acceptable for 70% of licensed acupuncturists to use Acu-Track Registry; it is acceptable for 70% of patients to complete questionnaires emailed to them via Acu-Track Registry.

The investigators propose to evaluate these hypotheses by conducting a prospective, pragmatic single-arm feasibility and acceptability study among individuals with chronic pain of any etiology or location, except if due to cancer. Chronic pain is defined as pain that persists or recurs for more than 3 months.

Eligibility Criteria:
Inclusion Criteria:

Patients:

* Age 18 or older;
* experiencing chronic pain,
* complaint of 3+ months,
* score of 5 or greater on a 1-10 scale;
* able to provide informed consent
* willing to sign an approved consent form that conforms to federal and institutional guidelines,
* English speaking and writing.

Exclusion Criteria:

Prior or current diagnosis of:

* cancer,
* Multiple Sclerosis (MS),
* any Dementia,
* Parkinson's Disease,
* Autism Spectrum Disorder,
* Pregnancy,
* Fibromyalgia,
* Eating Disorder,
* Down's Syndrome
* Schizophrenia
Narrow-Band Imaging Versus Standard White Light for the Detection of Serrated Lesions in the Proximal Colon

This is a study to determine if using Narrow-Band Imaging of the colon, rather than the usual white light on the colon, will improve the detection of a type of polyp called serrated. The polyps are called serrated because of their appearance under the microscope after they have been removed. They tend to be located up high in the colon, far away from the rectum. They have been definitely shown to be a type of precancerous polyp and it is possible that using Narrow-Band Imaging will make it easier to see them, as they can be quite difficult to see with standard white light.

This is a randomized controlled trial comparing the use of Narrow-Band Imaging (illumination of the colon in blue light)versus standard white light for the detection of serrated lesions in the proximal colon (the colon proximal to the splenic flexure). Recent studies have indicated that colonoscopy is more effective in preventing cancer in the left side of the colon than the right side of the colon. The reasons for this difference may be partly biologic, in that a special group of polyps known as serrated polyps, particularly sessile serrated adenomas, are located primarily proximal to the splenic flexure. These lesions share molecular features with a group of cancers that occur primarily in the proximal colon. These molecular features include CpG island methylator phenotype (CIMP) and microsatellite instability. These lesions are endoscopically subtle in that they are often flat, have the same color as the surrounding mucosa, and are hard to differentiate from normal mucosa. Narrow-Band Imaging has anecdotally been used to highlight the appearance of these lesions. This study will test whether Narrow-Band Imaging increases the detection of serrated lesions in a randomized controlled trial.

Eligibility Criteria:
Inclusion Criteria:

* Age 50-85
* Intact colon and rectum
* American Society of Anesthesiology risk class 1, 2 or 3

Exclusion Criteria:

* No prior surgical resection of colon or rectum
Observational Study of Type 2 Diabetes Patients Failing on Oral Anti-diabetic Agents Initiated on Levemir® or Insulatard®

This trial is conducted in Europe. The aim of this observational study is to evaluate the change in weight in type 2 diabetes patients using Levemir® or Insulatard® under normal clinical practice conditions.


Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetes
* HbA1c greater than 7.0% and/or hypoglycaemia
* variable FBG and/or weight increase
* the selection of the subjects will be at the discretion of the participating physician

Exclusion Criteria:

* non-type 2 diabetes
* current treatment with Levemir® or Insulatard®
* hypersensitivity to Levemir® or Insulatard® or to any of the excipients
* women who are pregnant, breast feeding or have the intention of becoming pregnant within next 6 months
Derris Scandens Benth Extract VS Naproxen in Knee OA

Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia. Previous study shown that D.Scandens Benth extract has the anti-inflammatory activity. Although NSAIDs are efficaciously in the treatment of osteoarthritis,but the GI side effect is still concerned. In this study we aim to investigate the efficacy and safety of D. Scandens Benth extract compared with Naproxen for therapy of patients with knee osteoarthritis.


Eligibility Criteria:
Inclusion Criteria:

* Age \>=50 yr
* Known case of primary knee osteoarthritis
* WOMAC pain subscale (item1) \>= 5
* signed informed consent

Exclusion Criteria:

* hypersensitive to NSAIDs
* history of peptic ulcer or melena
* unable to walk , i.e. patient with severe spinal stenosis, myocardial infarction
* history of intra-articular injection of knee within 3 months
* status post knee replacement
A Trial to Assess the Influence of a Pictorial Medication Calendar on Medication Taking Behaviour

Determine if an oncology pictorial medication calendar will improve patient adherence to oncology supportive care medication regimens for adult patients receiving adjuvant or neo-adjuvant chemotherapy treatment for cancer.

Primary Objective: In order to evaluate the impact of such an approach on adherence, a prospective, open-label, randomized controlled pilot trial (RCT) was carried out to determine if a picture-based medication calendar would improve patient adherence to antiemetic medication regimens for adult patients receiving chemotherapy treatment for solid organ tumor origins.

The secondary objectives were: 1) to assess medication use and self-efficacy parameters, 2) to determine patient comfort with antiemetic regimen prescribed along with chemotherapy and 3) to determine patient satisfaction with the calendar study tool.

Eligibility Criteria:
Inclusion criteria:

* Outpatients 18 years or older receiving chemotherapy treatment for neoadjuvant or adjuvant solid organ cancers,
* Able to provide consent for themselves,
* Calendar was only available in the English language, thus fluency in English was required.

Exclusion criteria:

* Participants who did not attain a minimum of grade 8 education,
* Significant visual impairment that precluded the ability to read the picture-based medication calendar,
* Difficulty swallowing with requirement for liquid formulations of medications,
* If planned to receive multiple cycles of chemotherapy at satellite oncology location instead of main study site,
* If unable to repeat the instructions back to research personnel or a care provider had to speak on the participant's behalf, the participant was withdrawn from the study.
Dose-response Relationship of Mustard Flour Footbaths in Healthy Volunteers

A study to explore whether different dosages of mustard flour in footbaths cause different effects on warmth development as well as on general well-being and the autonomic nervous system.

This is a blinded, four-arm randomized controlled trial with crossover design to explore the dose-response relationship of footbaths with different dosages of mustard flour in healthy volunteers, compared to a placebo control (footbath with warm water only). The main focus is on thermogenesis and warmth distribution, as assessed by high-resolution infrared thermography and questionnaire data before, during and after the intervention. In addition, effects on the autonomic nervous system are assessed by measuring various parameters of heart rate variability and pulse wave analysis.

Eligibility Criteria:
Inclusion Criteria:

* Written informed consent;
* Age between 18 and 55 years

Exclusion Criteria:

* Chronic skin lesions at the lower legs or feet
* Varicose veins grade 3 and grade 4 (Marshall stage classification)
* Chronic venous insufficiency
* Known intolerance or hypersensitivity to mustard preparations
* Cardiac arrhythmia
* Cardiac pacemaker
* Asthma bronchiale
* Consumption of HRV-modulating medication (especially tricyclic antidepressants, beta blockers)
* Pregnancy
* Insufficient knowledge of the german language
Eat, Move, Live Intervention in Reducing Chronic Disease Risk in Medically Vulnerable Communities

This randomized pilot research trial studies how well Eat, Move, Live (EML) works in reducing chronic disease risk in medically vulnerable communities. Obesity, unhealthy diet, and physical inactivity are linked to increased cancer risk, especially hormone-related cancer (example, breast cancer). Improving healthy lifestyle practices, namely increasing physical activity and encouraging healthy eating behaviors may reduce the risk of getting cancer and chronic disease.

PRIMARY OBJECTIVES:

I. Level of exercise.

II. Reduction in barriers to exercise.

III. Level of self-reported 5-9 servings of fruits and vegetables consumption.

IV. Reduction in barriers to fruit and vegetable consumption.

V. Improvement in biologic/metabolic markers such as hemoglobin A1c, fasting plasma glucose, and body weight.

OUTLINE: Participants are randomized to 1 of 2 groups.

GROUP I: Participants complete an assessment on knowledge, attitudes, and behaviors at baseline and attend 2 weekday sessions comprised of interactive education segment that is culturally responsive, and based on the community EML program, and topics including: nutrition guideline, nutrition label reading, comparison shopping/grocery store tour, recipe modification and healthy food preparation, eating healthy on a budget, and making healthy choices outside the home (e.g., restaurants) and physical activity over 1 hour led by Certified Health Educator (CHE), a physical activity conducted by Duarte Fitness Centers instructors over 30 minutes, and cooking/taste test demonstration co-led by the CHE and local chef over 30 minutes over 12 weeks. Participants are also prescribed and encouraged to participate in 3 days a week exercise classes (for \> 30 minutes) including salsa, Zumba and other aerobic exercises that are provided at Duarte Fitness Center.

GROUP II: Participants receive a fitness tracker to track their physical activity and be wait listed to receive the intervention during month 10-12.

After completion of study, participants are followed up immediately and at 3 months.

Eligibility Criteria:
Inclusion Criteria:

* Mothers/female guardians of elementary aged students
* Self identify as Latina
* Not adherent to the standard for \> five servings of fruits and vegetable and 150 minutes of physical activity

Exclusion Criteria:

* Not a parent of elementary aged student in Duarte Unified School District (DUSD)
* Does not self-identify as Latina
* Does not speak/read/write/understand English/Spanish - Diagnosed with diabetes
* Consumes 5+ servings of fruits and vegetables and is active for at least 30 minutes 5+ days per week
* Has a condition or psychological difficulties that affects day-to-day activities
* Has physical limitations and cannot participate in physical activity
Botulinum Toxin Injection Into Epicardial Fat Pads to Prevent Atrial Fibrillation in Patients Undergoing Cardiac Surgery

The aim of this prospective randomized double-blind study was to compare the efficacy of botulinum toxin injection in epicardial fat pads for preventing recurrences (in early postoperative period) of atrial tachyarrhythmia in patients undergoing cardiac surgery.


Eligibility Criteria:
Key inclusion Criteria:

* Indication for cardiac surgery (e.g. coronary artery bypass grafting, valve repair/replacement) according to the American College of Cardiology/American Heart Association (ACC/AHA) guidelines for cardiac surgery

Key exclusion Criteria:

* Planned maze procedure or pulmonary vein isolation
Trial of Orbital Atherectomy Versus Standard Strategy in Calcified Bifurcation Lesions

Clinical research with medical devices indicated in accordance with the CE marking, led by researchers, multicenter, open, prospective, randomized and controlled. Patients are randomized to treatment with a conventional balloon and then a coronary stent or to initial plaque modification with Orbital Atherectomy (OA) and then a coronary stent. To evaluate the efficacy and safety of OA in the adequate treatment with coronary stent of the calcified bifurcation lesion using angiography and optical coherence tomography (OCT).

The risk profile of patients and their comorbidities have worsened and the observed lesions undergoing treatment are increasingly complex. This has promoted the development of new technologies for plaque modification, especially in the context of calcified lesions. These predispose to suboptimal results of the intervention due to an increased risk of malapposition and underexpansion of the stents, the main variables for restenosis and/or thrombosis of the stents. Thus, compared with non-calcified lesions, the increased amount of calcium in the coronary artery leads to a higher incidence of major adverse cardiac events (MACE).

Coronary bifurcation stenting remains complex and is associated with a high risk of stent thrombosis and restenosis even with contemporary techniques, and suboptimal outcomes are frequently observed due to side branch (SL) involvement that increases cardiovascular events.

Our hypothesis is that the use of orbital atherectomy (OA) for coronary revascularization in the presence of calcified bifurcation lesions is feasible and safe compared to the more common technique, favoring the subsequent performance of provisional stenting (PS).

Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years of age and
* Patients with moderately or severely calcified bifurcation lesions (lateral vessel ≥ 2mm), candidates for PCI with coronary stent implantation, in whom there is the possibility of adequate clinical follow-up at 1 year and
* Patients agree to participate in the study, by signing the Informed Consent.

Exclusion Criteria:

* Patients with revascularization of the artery to be treated within 9 months prior to the index procedure.
* Patients with contraindication for the use of Orbital Atherectomy:

  * Patients in cardiogenic shock.
  * Patients with Thrombotic lesions.
  * Patients with Vascular graft disease.
  * Patients with remain vessel disease.
  * Patients with severe left ventricular dysfunction.
  * Patients allergic to the components of the washing serum (glide).
* Patients with life expectancy less than one year.
Improving Cervical Cancer Screening in Women Living With HIV Attending Chronic Disease Clinics in Semi-rural Tanzania

This study is to analyse the effect of a bundle of measures on the proportion of females being screened for cervical cancer in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO), comparing the time period before implementation (01/2017-01/2020) and after implementation (02/2020-06/2022). It is to assess the performance of two novel diagnostic tests (QuantiGene-molecular profiling histology (QG-MPH) and PT Monitor® immunoassay) and established tests (Seegene Anyplex™ II 28 HPV Test and Prevo-check®) as potential triage tests for the development of future clinical decision algorithms for CC screening.

Cervical cancer (CC) is the most common cancer among women living with HIV (WLWH) and the leading cause of cancer-related death in women in East Africa. Currently there are around 2800 WLWH in care at the Chronic Disease Clinic of Ifakara (CDCI), of whom only 8% attended CC screening services in the last three years.

This research project is to assess (with a mixed-method, before-/after-study) the impact of a bundle of procedures, which consists of: portable colposcopy, Human Papilloma Virus (HPV) testing and treatment of precancerous cervical lesions by Loop electrosurgical excision procedure (LEEP).

This study is also to analyze the prevalence of cervical disease in the cohort, stratified by stage and co-infections, as well as the acceptability, feasibility and costs.

Additionally, it will assess the performance of two novel diagnostic tests (QG-MPH and PT Monitor® immunoassay) and established tests (Seegene Anyplex™ II 28 HPV Test and Prevo-check®) as potential triage tests for the development of future clinical decision algorithms for CC screening. This is an implementational study nested within the KIULARCO study consisting of two interacting parts: a pre/post assessment of the impact of the bundle of interventions with mixed-methods study design and the diagnostic tests accuracy (evaluated with a cross-sectional study). The treatment investigated is regarded as standard treatment.

Eligibility Criteria:
Inclusion Criteria:

* WLWH enrolled in KIULARCO, who are at least 3 months on Anti-Retroviral Treatment (ART)
* 18-65 years of age
* Non-pregnant (reported)
* Signed informed consent

Exclusion Criteria:

* Pregnancy
* Known invasive cervical cancer
* Any condition interfering with visualization of the cervix
Towards Better Preparedness for Future Catastrophes - Local Lessons-learned From COVID-19

The research question of this study is: "what lessons have been learned from the civil-military cooperation in Heidelberg, Germany, during the COVID-19 pandemic, and what needs to be done to be better prepared for future disasters?" It is expected that the results of this research provide a deep expert insight into COVID-19 disaster preparedness at the local level. Flanked by comparison with published experiences at the global level, these lessons-learned would contribute to strengthening local crisis resilience sustainably in the future.

Design, execution, analysis and publication of this study is conducted in compliance with the international quality criteria "STrengthening the Reporting of OBservational studies in Epidemiology (STROBE)" and "Standards for Reporting Qualitative Research (SRQR)".

This is a monocentric, qualitative, mixed-methods, non-interventional, non-randomized research project.

Eligibility Criteria:
Inclusion Criteria:

1. Age over 18 years
2. Direct or indirect involvement in civil-military collaboration during the COVID-19 crisis
3. Ability to provide consent
4. Providing written informed consent to participate in the study

Exclusion Criteria:

1) Failure to provide written informed consent to participate in the study
Dermacyd PH_DETINLYN Tangerine Mix (Lactic Acid) - Photo Evaluation

The purpose of this study is to demonstrate the absence of photoirritation and photosensitization potential of the product Dermacyd PHDETINLYN Tangerine Mix (Lactic Acid).


Eligibility Criteria:
Inclusion criteria:

* Age between 18 and 60 years old;
* Phototype Skin II and III;
* Integral skin test in the region;
* Willingness in following the study procedures and to be present in the clinic at the days and scheduled time for medical evaluations and for application of occlusion;

Exclusion criteria:

* Lactation or gestation
* Use of Antiinflammatory and/or immunossupression drugs 15 days before the selection;
* Diseases which can cause immunity decrease, such as HIV, diabetes;
* Use of drug photosensitizer;
* History of sensitivity or irritation for topic products;
* Active cutaneous disease which can change the study results;
* History of photodermatosis active;
* Family or personal antecedent of cutaneous photo induced neoplasias;
* Presence of a precursor lesion of cutaneous neoplasia, such as nevus melanocyte and queratoses actinium;
* Intense solar exposure in the study area;
* Use of new drugs or cosmetics during the study;