cyrilzakka/clinical-trials huggingface dataset:
Efficacy of Scapulothoracic Exercises on Postural Stability, Proprioception, Muscular Features and Mandibular Functions

The goal of this Randomized, Double-Blind, Clinical Trial is to investigate the effects of scapulothoracic exercises on postural stability, muscle strength, muscular endurance, mandibular functions and proprioception in sedentary individuals aged 18-45 years with head forward posture and temporomandibular joint dysfunction (Cranio-Cervico-Mandibular Malalignment). The main questions it aims to answer are:

• Do Scapulothoracic exercises given in addition to cervical posture exercises have an effect on postural stability, proprioception, muscle strength, muscular endurance and mandibular functions in individuals with Cranio-Cervico-Mandibular malalignment?

Researchers will compare conventional neck exercises (control group) and scapulothoracic exercises applied in addition to conventional neck exercises (treatment group) to see the effects of scapulothoracic exercises on the neck and jaw area.

The investigators aimed to investigate the effects of scapulothoracic exercises on postural stability, muscle strength, muscular endurance, mandibular functions and proprioception in sedentary individuals aged 18-45 years with cranio-cervico-mandibular malalignment including head-first posture and temporomandibular joint dysfunction problems.

Eligibility Criteria:
Inclusion Criteria:

* Male and female students and employees between the ages of 18-45,
* Individuals with a craniovertabral angle (CVA) \<50° and a Fonseca questionnaire score between 20-100,
* Individuals with a Helkimo clinical dysfunction index score between 1-25,
* Individuals with a low level of physical activity according to the International Physical Activity Questionnaire.

Exclusion Criteria:

* Serious problems of the musculoskeletal system, including the cervical and thoracic spine,
* Presence of serious chronic diseases such as hypertension, diabetes, cancer,
* Presence of neurological disease at a level that will affect balance and postural control,
* Being pregnant,
* Tooth and jaw problems in the last 6 months,
* Individuals with a total denture or prosthesis on the anterior teeth.
Paramedical Consultation in Telemedicine

Feasibility monocentrique opened study estimating the use of an electronic personalized educational plan (ePEP) for the follow-up by nurses of 50 patients diabetics type 1 during 6 months having an electronic pad.


Eligibility Criteria:
Inclusion Criteria:

* patient diabetic type 1
* patient with the electronic pad in a smartphone
* adults
* children between 12 and 17 years 11 months
* patient having signed the consent

Exclusion Criteria:

* patient diabetic type 2
* patient without the electronic pad in a smartphone
* children below 12 years old
Ultrasound-guided Subclavian Vein Catheterisation With a Needle Guide

OBJECTIVES The primary objective is to compare if the addition of a needle guide can reduce the number of central venous catheter (CVC) insertions with \>1 skin puncture in ultrasound-guided catheterization of the subclavian vein using the long-axis approach with an in-plane needling technique.

Secondary objectives include if this addition 1) decreases the frequency of mechanical complications (defined as bleeding, arterial puncture, arterial catheterization, nerve injury, pneumothorax), 2) increases the time when the needle is visible, 3) decreases the time until successful vessel punction, 4) decreases the number of needle redirections during the insertion, and 5) a comparison between the two groups regarding number of failed catheterizations.

DESIGN This is a prospective, randomised, controlled, parallel intervention study. Patients will be enrolled at Skåne University Hospital in Lund, Sweden. The trial is investigator-initiated and non-commercial.

POPULATION AND INTERVENTION Adults (18 years of age or older) in need of a subclavian CVC for any reason and able to give written informed consent will be included in the study provided no exclusion criteria is fulfilled.

OUTCOMES Primary outcome will be number of CVC insertions with \>1 skin puncture. Secondary outcomes include comparison between the two groups regarding 1) the frequency of mechanical complications, 2) proportion of the insertion-time when the needle is visible on the ultrasound (US) screen, 3) time to successful vessel punction, 4) the number of needle redirections during the insertion, 5) number of failed catheterisations, 6) Feasibility of the needle guide evaluated with a questionair to the operators at the end of the study.


Eligibility Criteria:
Inclusion Criteria:

* Patients in need of a central venous catheter .
* Clinical indication for the subclavian route which includes expected time of use \>5 days.
* Signed informed consent.

Exclusion Criteria:

* Patient is deemed unsuitable for cannulation of the subclavian vein, based on a pre-procedural US examination by the operator, or due to unacceptable patient risk in case of mechanical complication (e.g., severe respiratory failure).
Treating the Partners of Drug Using Pregnant Women: Stage II

This is a two group randomized design that will compare a novel therapy package (i.e., Research supported treatment intervention, Contingency-based voucher incentives for the male partner's drug abstinence, Specialized MI couples counseling) to standard care for helping drug using partners of drug dependent pregnant women obtain and maintain drug abstinence. Participants will be followed for 22 weeks and have scheduled twice weekly urine sample collection and all participants will have follow-up interviews post-study entry.


Eligibility Criteria:
Inclusion Criteria:

* are 18 years of age or older on admission;
* Pregnant as determined by sonogram results
* have a current sexual partner who they have seen recently at least 3 times a week
* male partner has regular alcohol or illicit drug use (at least 4 of 7 days typical use) and is not incarcerated.

Exclusion Criteria:

* woman or partner report current suicidal ideation
* woman or partner meet diagnostic criteria for a current DSM-IV Axis I thought disorder (i.e. schizophrenia)
* woman or partner demonstrate significant cognitive impairment that precludes them from completing the initial assessment battery
* woman has evidence of physical violence or abuse
Pneumatic Retinopexy for Primary Rhegmatogenous Retinal Detachment: To Steamroll or Not

This is a randomized controlled trial comparing displacement of macula and the rapidity of reattachment of macula between two different positioning techniques after pneumatic retinopexy : Direct technique (patient is positioned so that the bubble is immediately placed directly over the retina break) and Steamroller technique (patient is initially positioned face down for 4-6 hours and subsequently changes their head position so that the bubble is then placed directly over the retina break).

Pneumatic retinopexy (PR) is an established treatment for rhegmatogenous retinal detachment (RRD). In our centre, PR is the most commonly performed procedure for primary RRD repair with a high retinal reattachment success rate. In this procedure, patients are required to position according to the site of pathology following injection of an intravitreal gas bubble. Some practitioners position the patient so that the gas bubble is immediately apposed directly against the retinal break (direct technique). Others favour the steamroller technique whereby the patient is initially positioned face down, then after 4-6 hours, the position is changed sequentially so that the bubble is rolled over the retina towards the break responsible for the detachment (steamroller technique). Variable visual acuity (VA) outcomes and metamorphopsia are common post-procedure complaints despite successful RRD repair with PR. It has been suggested that variability in functional outcomes may be associated with the timing and ease of reattachment of macula. The purpose of this prospective study is to evaluate whether the steamroller technique is superior to the direct technique in faster reattachment of macula with less macula displacement.

Eligibility Criteria:
Inclusion Criteria:

* Primary RRD
* Causative breaks over superior 8 clock hours
* Single break or group of breaks
* No or min proliferative vitreoretinopathy (PVR) (Grade A or B)
* Other breaks or lattice in attached retina are allowed

Exclusion Criteria:

* Retinal break in the inferior 4 clock hours in detached retina
* PVR Grade C or worse
* Significant media opacity (Vitreous hemorrhage, dense cataract, cornea scar, etc)
* Pre-existing ocular pathology \[macula hole (MH), epiretinal membrane (ERM), cystoid macula edema (CME), age-related macula degeneration, myopic degeneration, advanced glaucoma, uveitis, amblyopia etc\] or previous eye trauma with poor baseline vision
* Previous pars plana vitrectomy
* Age ≤18years old
* Inadequate physical or mental competence to maintain the required postoperative head position
Spine Surgery Video Observation Study. The Creation of a Benchmark Video (RGB-Depth) Dataset to Investigate the Feasibility of Developing a Markerless Tracking System for Spine Surgery.

The primary study objective is to build a video dataset, consisting of both colour and depth information, of spine surgery that includes both 'open' and 'minimally invasive' (MIS) surgeries. Using accompanying preoperative CT scans of the patient's spine, we aim to develop a markerless tracking system for spine surgery, which the collected dataset will be used to both train, and then benchmark against.


Eligibility Criteria:
Inclusion Criteria:

* Candidate surgeries include all spine surgeries taking a posterior approach. This includes both 'open' and 'minimally invasive' surgeries, provided some portion of vertebrae bone is exposed.

Exclusion Criteria:

* Candidate surgeries will be excluded if the patient is under the age of 18 or the clinical lead feels the patient lacks capacity to consent.
Self Tonometry and Transfer of Glaucoma Patients' Data for Improving the Supply Situation

The SALUS project is developing a new form of care, the application of self-tonometry by the patient itself, and an accompanying electronic case file connecting clinics, doctor's offices and patients.

The SALUS project is developing an outpatient, intersectoral form of care in which patients measure their intraocular pressure in their home environment with a so-called self-tonometer. The measured intraocular pressure values are incorporated into daily pressure profiles, which can be viewed via an electronic case file together with further examination data both by the treating ophthalmologists in the doctor's offices and clinics and by the patients. The new form of care not only supports the telemedical networking of doctors but also increases the compliance by involving the patient in the entire course of the illness.

Eligibility Criteria:
Inclusion Criteria:

* Requirement of a stationary day and night measurement
* Statutory health insurance
* Verified and suspicion of glaucoma diagnosis with suspicion of pressure variations and peaks or not attained target pressure or suspicion of glaucoma progression (H40.1, H40.2 und H42.-)
* Willingness for therapy in one of the participating clinics
* Adequate German language skills
* Signed and dated informed consent for study participation and data transfer
* Legal capacity of the insurant to agree to the study participation

Exclusion Criteria:

* Patients outside the catchment area of the participating clinics
* Covering illnesses in psychiatry, neurology or other indications (e.g. impairment of independence) which make self-tonometry impossible
* Strong communication barriers that do not allow the instruction to carry out the intervention
* Unclear legal capacity of the potential study participants
Dating Violence Prevention Program Focusing on Middle School Boys

This study will test a web-based intervention to enhance emotion regulation skills and parent-son relationship communication to decrease adolescent boys' risk for dating violence involvement as well as attitudes supporting relationship aggression.

Over the past ten years dating violence (DV) has been recognized as a significant public health problem affecting adolescents. Emerging data suggest that boys and girls have different developmental trajectories toward violence and therefore prevention programs that target their unique pathways to DV are needed. Despite this need, there is a relative dearth of such gender-informed programs for early adolescent boys. This research project aims to prevent the emergence of DV perpetration/ victimization among boys by developing a web-based intervention that is informed by research on gender-specific pathways to violence and harnesses the influence of parents during the early adolescent years.

Among boys, the perpetration of delinquency-related violence and attitudes supporting violence has been found to predict later perpetration of DV. Thus, gender-informed interventions designed to prevent DV in boys need to target skills that underlie violent behavior and attitudes. The goal of this study is to test a web-based intervention to enhance emotion regulation skills and parent-son relationship communication to prevent DV.

A pilot trial was conducted to create and test the efficacy of the web-based intervention. Preliminary results suggested the program was effective in reducing dating-violence involvement. This Randomized Controlled Trial (RCT) will test the efficacy of the intervention against an active control designed to provide health related information in a format similar to that of the intervention condition. 340 families (English or Spanish-speaking) will be randomly assigned to complete the intervention program or the health-promotion control program. All families will complete the program in an observed setting, to ensure fidelity to intervention dosing. Parents and adolescents will complete the program together and then complete assessments of aggressive and risk behaviors, parent-child communication, and emotion regulation at baseline, 3-month,6-month, 12-month, 18-month, and 24-month follow-ups.

Eligibility Criteria:
Inclusion Criteria:

1. adolescent is between 12 and 15 years old
2. adolescent identifies as male
3. adolescent enrolled in the 7th or 8th grade at a participating school,
4. parent/legal guardian and teen are English or Spanish speaking,
5. parent/legal guardian and son reside together at least 50% of the time,
6. parent/legal guardian is willing to provide consent for the adolescent to participate in the study,
7. adolescent is willing to provide assent for their own participation.

Exclusion Criteria:

1. adolescent or parent is unable to read at a 4th grade level or has developmental delays,
2. other family members in household have previously participated in the study
Potential of Circulating Tumor DNA to Assess the Tumor Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

Breast cancer is the most common malignant tumor in women worldwide,and there exist a large part of patients need to receive neoadjuvant chemotherapy(NAC) before the curative surgery.Circulating tumor DNA(ctDNA) is the circulating free DNA in the blood that originates from cancers,and it can be detected by modern technologies in plasma.In this prospective study,investigators aim to observe the correlation between tumor response to neoadjuvant chemotherapy and ctDNA.

Women with node-positive breast cancer are at high risk for recurrence. Neoadjuvant chemotherapy is traditionally for locally advanced disease, converting an inoperable tumor to a resectable one.In the present study, investigators will focus on breast cancer patients whose primary tumors are large or have lymph node metastases and need to receive neoadjuvant chemotherapy from 2018 to 2019. Circulating tumor DNA(ctDNA) will be obtained from peripheral blood,and the blood samples will be taken before the neoadjuvant chemotherapy、during the chemotherapy、 before the surgery and post surgery visit (within 24 hours after surgery) .Investigators will collect tissue samples both from the breast lump biopsy and the curative surgery. Investigators aim to investigate whether circulating tumor DNA is a sensitive marker to monitor the efficacy of neoadjuvant chemotherapy in breast cancer.

Eligibility Criteria:
Inclusion Criteria:

* Female patients undergoing neoadjuvant chemotherapy
* Age: 18-70 yrs
* Any menopausal status
* Any hormone receptor status
* Invasive breast cancer proven histologically at diagnosis (before neoadjuvant chemotherapy):
* Locally advanced tumor
* Patients who received 6 to 8 cycles of neoadjuvant chemotherapy.

Exclusion Criteria:

* Failed to retain blood sample before NAC
* Lost more than 2 blood samples during NAC
QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma

This is a phase 2, multicenter, randomized, double-blind, double-dummy, placebo-controlled, three-arm trial to be conducted in the United States, Europe, and Asia. Approximately 150 eligible KRAS-mutant metastatic colorectal cancer subjects who have failed first line fluoropyrimidine and oxaliplatin-based regimen with or without anti-VEGF therapy will be randomized in a 1:1:1 ratio to receive AMG 479 placebo plus AMG 655 with FOLFIRI, or AMG 479 plus AMG 655 placebo with FOLFIRI, or AMG 479 placebo plus AMG 655 placebo with FOLFIRI


Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed adenocarcinoma of colon or rectum in patients with metastatic disease
* Mutant-type KRAS tumor at screening
* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1
* Adequate hematology, renal, hepatic, and coagulation function

Exclusion Criteria:

* History or known presence of central nervous system metastases
* History of other malignancy
* Prior irinotecan-based chemotherapy for advanced/metastatic disease
* Prior death receptor agonists, or other systemic IGF-1R agonists in any setting
* Uncontrolled cardiovascular disease
The Effect of Education on Patient Care Outcomes in Individuals With Diabetic Foot Ulcer

The aim of this study is to determine the effect of Social Cognitive Learning Theory-based education on patient participation, self-efficacy and wound healing in individuals with diabetic foot ulcers. The research was conducted with 52 patients (25 intervention and 27 control) with Wagner 2 diabetic foot ulcers at Gülhane Training and Research Hospital between January and September 2024.

The study was conducted in four stages: first application to the clinic, 1st month, 2nd month and 3rd month. While the Social Cognitive Learning Theory was applied to the intervention group, only the currrent clinical education was provided to the control group. The research data were collected using the "Data Collection Form Regarding Participants' Identifying Characteristics", "Diabetic Foot Information Form", "Metabolic Status and Wound Follow-up Form", "Patient Participation Scale" and "Diabetic Foot Care Self-Efficacy Scale". The results of this study show that education based on Social Cognitive Learning Theory is effective on patient participation, self-efficacy and wound healing in individuals with diabetic foot ulcers.

Eligibility Criteria:
Inclusion Criteria:

* Individuals 18 years of age or older Agree to participate in the study Have type 2 diabetes Have a Wagner classification score of 2 Have the same wound care protocols (epidermal growth factor/hyalunoric acid containing cream and dressing with gauze)

Exclusion Criteria:

* Having communication difficulties and mental retardation Having vision and manual dexterity problems Having diabetic foot infection
Molecular and Immunohistochemical Profiling of Tumors in Patients with Parathyroid Tumors

This trial studies molecular and immunohistochemical profiling of tumors in patients with parathyroid tumors. Studying molecular and immunohistochemical profiling of tumors may help doctors avoid inconsistencies in diagnosis, unnecessary or incomplete surgery, surgical morbidity, psychological stress, and inadequate follow up.

PRIMARY OBJECTIVES:

I. To determine the differences in clinical behavior and immunohistochemical (IHC) biomarkers between parathyroid carcinoma (PC), atypical neoplasm (AN) and parathyroid adenoma (PA).

II. To determine which potential genes can be used in patients with parathyroid tumors for diagnostic purposes.

OUTLINE:

Previously collected tumor tissue and blood samples are analyzed via immunohistochemical profiling for identifying potential genes showing molecular aberrations as other types of cancer.

Eligibility Criteria:
Inclusion Criteria:

* The patient cohort for this study consists of all patients within the prospectively maintained parathyroid database within the Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center (MDACC) or from collaborating sites, with tissue or blood available from 1968-2015, previously consented for the use of the tissue for research purposes (via Protocols LAB 08-0034, PA11-0695 and LAB03-0320 or the appropriate external mechanism for collaborating sites).
* All patients with a known diagnoses of primary hyperparathyroidism (PHPT) operated/treated in the Department of Surgical Oncology of MDACC or at a collaborating site. Patients that have provided consent for the use of the tissue or blood for research purposes will then be considered for our study (via Protocol LAB03-0320 and LAB 08-0034 or the appropriate external mechanism for collaborating sites).
* All consented patients with known diagnoses of PHPT with a histopathological diagnosis of: parathyroid carcinoma, atypical parathyroid neoplasm or parathyroid adenoma. There will be no restrictions on age, gender, or ethnicity.
* Selected patients obtained through outside collaboration who meet the selection criteria for tissue availability and diagnostic suitability for inclusion in the study.

Exclusion Criteria:

* Patients without tissue available for analysis.