cyrilzakka/clinical-trials huggingface dataset:
Safety of 6 Hours Feeding After Extracorporeal Shock Wave Lithotripsy of Pancreatic Stone

The purpose of this study is to evaluate the safety of eating 6 hours after Extracorporeal Shock Wave Lithotripsy (ESWL). At present, ESWL and Endoscopic Retrograde Cholangiopancreatography (ERCP) are the routine ways to treat pancreatic duct stones. For large stones (diameter \> 5mm) , ESWL often needs to be performed many times. In clinical practice, fasting for 24 hours after surgery is often used, but long-term fasting brings strong discomfort to patients. However, the consensus for initiation timing of oral nutrition has not yet been established after ESWL. Thus, we design this trial to evaluate the safety of early feeding based on 6 hours parameter instead of the consensus definition.

In recent years, studies have shown that early recovery of enteral nutrition has significant benefits for patients. Early recovery of oral feeding and drinking as well as early oral supplementary nutrition after surgery can promote the recovery of intestinal motor function, help maintain intestinal mucosal function, prevent postoperative flora disorder and diarrhea, shorten postoperative hospital stay, and improve postoperative anxiety of patients.This study mainly evaluated the safety of feeding 6 hours after ESWL, including the risk of post-ESWL pancreatitis and other adverse events, as well as the length of hospital stay, medical expenses, pain, etc. This research conclusion is helpful to provide more scientific and reasonable fasting time for patients after ESWL, improve patient comfort, reduce the risk of adverse events, shorten hospital stay, save medical expenses, and guide clinical practice.

Eligibility Criteria:
Inclusion Criteria:

* Patients with chronic pancreatitis who completed ESWL.

Exclusion Criteria:

* Readmitted to the hospital during enrollment of the study;
* Cannot eat or rely on jejunal nutrition tube to give total parenteral nutrition for various reasons;
* With acute pancreatitis, perforation, infection, bleeding, steinstrasse and other complications and other serious clinical adverse events within 6 hours after ESWL;
* Suspected or confirmed malignancy
* Pancreatic ascites;
* Coagulation dysfunction;
* Taking chemotherapy drugs and immunosuppressants for a long time;
* Acute pancreatitis exacerbation or acute exacerbation of chronic pancreatitis (including biliary pancreatitis);
* Pregnant or breastfeeding women;
* Patients who refused to participate in the study.
Efficacy of Coherence Therapy for Procrastination

The purpose of this study is to determine the efficacy of Coherence Therapy in treating procrastination. For that, this intervention is compared to Cognitive-Behavioral Therapy which was already proved to be efficacious in treating this problem. The method used is a randomized controlled trial.

Procrastination is a recognized difficulty that entails negative outcomes regarding performance and subjective well-being. In order to find effective treatments for procrastination, the present study wants to test the efficacy of Coherence Therapy, compared with Cognitive Behavioral Therapy. Procrastination, negative emotional states and cognitive structure will be assessed in pre-treatment and post-treatment evaluation. A total of 30 students will be randomly assigned to Coherence Therapy (n=15) or Cognitive Behavioral Therapy (n=15). In both forms of treatment students will receive three weekly sessions and one more session six to seven weeks after the third session. The treatment will be provided by trained psychotherapists. Findings would clarify the effectiveness of Coherence Therapy for the treatment of procrastination and the change of emotional states and cognitive structure of the students after the treatment.

Eligibility Criteria:
Inclusion Criteria:

* Being a student
* 19-26 years old
* A score above 51 on the General Procrastination Scale

Exclusion Criteria:

* Being currently under a psychological treatment
* Being diagnosed lately with any mental disorder
* Mental retardation
* Substantial visual, hearing or cognitive deficits
* Psychotic symptoms
* Organic brain dysfunction
Pulsed Radiofrequency vs Dry Needling in Myofascial Pain

Myofascial pain (MPS) is the leading cause of chronic and persistent regional pain, affecting as many as 85% of the general population. A variety of treatment methods for myofascial pain have been investigated, including injection of saline, local anesthetics and steroids, dry needle, mini-scalpel, rich platelet plasma and radiofrequency ablation. Ultrasound guided dry needle (DN) and pulsed radiofrequency ablation (PRF) of the trigger point have been considered as two effective and promising treatments for myofascial pain. As far as searched, we failed to identify any study comparing the effects of DN and PRF in myofascial pain patients.


Eligibility Criteria:
Inclusion Criteria:

1. Aged between 18 and 70 years old.
2. Chronic (\>3 months) myofascial pain in the neck, shoulder, and upper back region.
3. Myofascial pain will be diagnosed based on Simons and Travell's criteria: taut band palpable, exquisite spot tenderness of a nodule in a taut band, patient's recognition of current pain complaint by pressure on the tender nodule, and painful limit to full stretch range of motion.
4. Have at least a pain VAS score of 40 mm; thus, a minimal clinically significant change is detectable.

Exclusion Criteria:

1. History of receiving DN or PRF treatment or currently undergoing other pain-related treatments (acupuncture, laser, infrared therapy, etc.).
2. Presence or history of trauma, surgery, or infection in the pain region.
3. Current or history of taking moderate to strong analgesics, such as tramadol and morphine.
4. Severe systemic disease (eg. severe hepatic or renal dysfunction), coagulopathy, or medications affecting the coagulation system.
5. Allergy to medications used.
6. Pregnancy, psychiatric disease, medical background, inability to cooperate, or refusal to participate.

Withdrawn Criteria:

1. Unwilling to continue participation or unable to follow the treatment plan.
2. Unable to obtain the primary outcome data due to any reason.
Improving Clinical Staging for Muscle Invasive Bladder Cancer Through Molecular Profiling and Improved Imaging

The goal of this research study is to improve detection of cancer outside of the bladder through genetic testing and improved imaging.

If participant agrees to take part in the study, a piece of the tumor that is removed during the biopsy will be collected for research purposes. The tissue will be sent to the laboratory for genetic testing.

If they have had a computed tomography scan (CT scan) or magnetic resonance imaging scan (MRI) recently, information collected from the scan will be collected. If they have not had one recently, they will have an MRI with contrast as part of this study. They will receive a separate consent form for this MRI scan.

The results of the test will be given to their doctor, but the results will not be used to decide their treatment.

After they have surgery, information will be collected from their medical records, such as their diagnosis.

Length of Study:

* Their participation on this study will be over once their surgery is completed.
* This is an investigational study.

Up to 100 participants will take part in this study. All will be enrolled at MD Anderson.

Eligibility Criteria:
Inclusion Criteria:

1. Patients with biopsy proven bladder cancer of any age will be eligible for enrollment.

Exclusion Criteria:

1. Contraindication to pelvic MRI (metallic implants/hardware, claustrophobia)
2. Participants who have previously received chemotherapy as part of multimodal therapy.
Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients

Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality. However, the reasons for this remain unclear. Therefore, the goal of this study is to investigate diastolic dysfunction in septic patients on the intensive care unit. Special attention is paid to the presence of lung edema and general edema as a potential link between diastolic dysfunction and elevated mortality in septic patients. During the septic phase daily ultrasound examinations of heart and lung will be performed as to monitor diastolic function and lung edema.


Eligibility Criteria:
Inclusion Criteria:

* Patients on the intensive care unit diagnosed with SIRS (systemic inflammatory response syndrome) or Sepsis.

Exclusion Criteria:

* Patients with hemodynamically relevant cardiac defects.
* Patients with mitral valve replacement.
* Patients with pericardial effusion.
* Patients with atrial fibrillation.
* Patients with pacemaker therapy.
* Patients with BMI \> 35 kg/m2.
* Patients with poor examination conditions for ultrasound.
Prediction of the Risk of Placental Vascular Pathology and Venous Thromboembolic Disease

Venous thromboembolic (VTE) disease is the first cause of maternal mortality in the world. Some other pregnancy pathologies called Placental Vascular Pathologies (PVP) are linked to VTE by biological thrombophilia and are the principal cause of perinatal mortality. the identification of predictive factors of risk of occurrence or recurrence of two pathologies could enable us to propose an appropriate monitoring of patients at risk.

Main aim: To evaluate echographic, doppler and biological markers in a prospective manner as a potential predictive factor of risk of PVP and VTE.

Eligibility Criteria:
Inclusion Criteria:

* previous history of one or more PVC episodes (preeclampsia, HELLPs, retroplacental hematoma, vascular IUGR\<10th percentile, recurrence miscarriage \>2, unexplained IUFD or IUFD after abruption placentae, eclampsia.
* Previous history of personal VTE
* Diabete (treated with diet or insulin)
* chronic hypertension
* chronic renal pathology
* lupus
* obesity
* Antihopholipids syndrome
* early and late pregnancy (\<18 years, \>38 years)
* family history of cardiovascular disease of VTE
* known biological thrombophilia without any personal past history of PVC or VTE

Exclusion Criteria:

* Multiple pregnancy
* past history of in utero fetal death due to congenital malformations, rhesus incompatibility or an infection
* previous history of IUGR which etiology was a chromosomal, genic or infectious anomaly
Neural Mechanisms for Appetitive Responses to High Reward Foods

This study is aimed at understanding neuroendocrine responses to different types of sugars and how this influences feeding behavior among lean, overweight, and obese individuals.

The investigators have previously combined functional magnetic resonance imaging (fMRI) with hormonal and behavioral assessments to better understand the impacts of glucose and fructose on appetite and its central regulation in humans and have made important observations in lean individuals linking fructose consumption to overeating and obesity. The investigators now propose to expand this work by examining the impacts of glucose and fructose ingested together (sucrose), as occurs in real life, and by examining effects of a common non-nutritive sweetener, sucralose, on brain and appetitive response. The investigators propose a random-order crossover design to determine the effects of caloric and non-nutritive sweeteners among lean, overweight, and obese participants. The investigators will measure circulating levels of hormones involved in satiety signaling, quantify food intake, and measure brain activity using blood-oxygen level dependent and arterial spin labeling methods and functional connectivity analyses.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-35 years, right-handed, weight change \<2% for at least 3 months prior to participation, no history of diabetes or other significant medical problems, fasting glucose \<126 mg/dl.
* Lean group: BMI of 19-24.9 kg/m2
* Obese Group: BMI 30-40 kg/m2
* Overweight Group: BMI of 25-29.9 kg/m2

Exclusion Criteria:

* Neurological, psychiatric or addiction disorder, fasting glucose ≥126 mg/dl, use of prescription medication (with the exception of contraceptives), tobacco use, contraindications to MRI scanning (detailed in Protection of Human Subjects), fructose intolerance, history of eating disorder, actively trying to lose weight.
Goals of Care Conversations Study

The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values. The objective of this study is to use a sequentially randomized trial to determine what implementation strategies are effective to increase early, outpatient goals of care conversations. The study will use interviews with and surveys of medical providers, patients, and caregivers, along with medical record data. This work is significant because it tests ways Veterans can express their goals and preferences for life sustaining treatments and have them honored.

The aims of this study are as follows:

Aim 1. Use a clinician-level SMART in three VA health systems to determine the effectiveness of clinician and patient implementation strategies to improve the occurrence of documented goals of care conversations in Veterans with serious medical illness. Hypothesis 1 (first stage of the SMART): Compared to a low intensity clinician strategy alone, a low intensity clinician and patient strategy will lead to increased documentation of goals of care conversations. Hypothesis 2. Among those who do not respond to low intensity strategies, compared to a high intensity clinician strategy paired with a low intensity patient strategy, a high intensity clinician and patient strategy will lead to increased documentation of goals of care conversations.

Aim 2a. Identify the sequence of implementation strategies that leads to the overall greatest increase in documentation of goals of care conversations. Aim 2b (exploratory). Identify patient and clinician characteristics that modify the effect of sequences of implementation strategies on documentation of goals of care conversations.

Aim 3. Understand clinician and patient implementation strategy success or failure using a mixed method evaluation involving clinicians, leaders, patients, and caregivers.

Eligibility Criteria:
Inclusion Criteria:

CLINICIANS VA primary care advance practice clinicians (MDs, APRNs, PAs) at one of the three study sites able to complete goals of care conversation notes and orders. Advance practice clinicians will be eligible for randomization if they have at least 15 eligible patients without goals of care conversation notes at the start of stage 1 (to allow participating clinicians ample opportunities to write notes) and have written fewer than 4 goals of care conversation notes in the previous 6 months (to select clinicians who need improvement), and can potentially receive the planned implementation strategies, i.e., clinicians who regularly attend the Patient Aligned Care Team (PACT) team meetings.

PATIENTS

* Veteran enrolled in VHA health care in one of the three study sites who is a current patient of one of the eligible primary care clinicians
* Diagnosis of cancer, heart failure, interstitial lung disease, chronic obstructive pulmonary disease, end-stage renal disease, end-stage liver disease, and dementia
* Care Assessment Need score of \> or equal to 90 using the one-year combined hospitalization/mortality variable

Exclusion Criteria:

PATIENTS

* Prisoner
* Pregnant
* under 18 years of age.
Role of PTK-7 in Acute Myeloid Leukemias

The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned to the planar cell polarity pathway. PTK7 is expressed in normal myeloid progenitors and CD34(+) CD38(-) bone marrow cells in humans. It is also expressed in acute myeloid leukemia (AML) and is mostly assigned to granulocytic lineage differentiation. In AML, PTK7 seems to convey promigratory and antiapoptotic signals into the cell and represents an independent prognosis factor of survival in patients treated with induction chemotherapy. This study aims at:

* evaluating the impact of PTK7 expression on primary AML cells ex vivo
* evaluating the diagnostic and prognostic value of a soluble form of PTK7


Eligibility Criteria:
Inclusion Criteria:

* Age\> 18 years
* AML at diagnosis, not previously treated
* Treatment by induction chemotherapy
* Signed informed consent
* Affiliation to the French social security system

Exclusion Criteria:

* pregnant woman(or of childbearing potential) or breastfeeding woman
* emergency
* patients deprived of liberty or placed under the authority of a tutor
Intermittent Fasting (IF) Has Gained Recognition As a Promising Weight Loss Approach That Improves Body Weight, Insulin Resistance, and Metabolism. While Standard Diets Are Common in PCOS Management, IF May Address the Underlying Causes of Weight Gain and Offer Additional Metabolic Benefits

The goal of this clinical trial is to learn if dietary interventions works to improve anthropometric measures in women with PCOS. The main questions it aims to answer are:

* Does intermittent fasting (IF) cause loss of body weight, fat and muscle mass?
* Can IF be considered more effective to medical and standart nutrition therapy (SDT)?
* What dietary problems do participants have when having IF diet?

Participants will:

* Follow IF, SDT, or no intervention for 8 weeks.
* Visit the clinic once every 2 weeks for check ups with a total of 5 visits for intervention groups IF and STD, visit at the beginning, second week and at the end for control group
* Keep dietary records

It was conducted in individuals who were diagnosed with PCOS as a result of clinical, biochemical and ultrasonographic medical evaluation by a gynecologist.

Eligibility Criteria:
Inclusion Criteria:

* Voluntariness to participate in the study
* BMI between 25-35 kg/m2
* Women between the ages of 18-45

Exclusion Criteria:

* An endocrine disorder other than polycystic ovary syndrome
* Chronic liver and kidney disease,
* Diabetes,
* Hypertension,
* Hyperuricemia,
* Heart Failure,
* Thyroid disease,
* Pregnant and breastfeeding women,
* Individuals with psychiatric disorders,
* Oncological diseases,
* Women using medication,
* Those with pacemakers and platinum,
* Those with special nutritional needs
Tiotropium/Salmeterol Inhalation Powder (Spiriva Handihaler and Salmeterol Polyethylene (PE) Capsule) in Chronic Obstructive Pulmonary Disease (COPD)

The primary objectives of this study are to assess bronchodilator efficacy as determined by forced expiratory volume in one second (FEV1), the effect on dyspnoea as determined by the Baseline Dyspnoea Index/Transition Dyspnoea Index (BDI/TDI), the effect on health status as determined by the St George Respiratory Questionnaire (SGRQ) and the effect on chronic obstructive pulmonary disease (COPD) exacerbations.


Eligibility Criteria:
Main Inclusion criteria:

* Diagnosis of COPD
* Post-bronchodilator FEV1\<80% predicted and FEV1/FVC\<70% predicted

Main Exclusion criteria:

* Significant other diseases then COPD
* Recent myocardial infarction (MI)
* Unstable or life-threatening arrythmia requiring intervention or change in drug therapy
* Hospitalisation for cardiac failure in past year
* History of asthma
Post Marketing Observational Study of Reformulated BeneFIX

The primary objective of this observational study is to collect safety data on reformulated BeneFIX as prescribed in routine clinical practice conditions in France. The secondary objectives are to collect data on the clinical course of individuals treated with reformulated BeneFIX and on the ease of reformulated BeneFIX.

No sampling

Eligibility Criteria:
Inclusion Criteria:

* Subjects with Hemophilia B already receiving or starting treatment with reformulated BeneFIX.
* Subjects who have dated and signed the informed consent form.

Exclusion Criteria:

* Ongoing treatment of Hemophilia B by a product other than reformulated BeneFIX.
* Participation in the European prospective registry of patients with Hemophilia B treated with BeneFIX (Wyeth protocol 3090A-101039).
Mulligan Mobilizations and McKenzie Exercises Along With Neural Mobilizations in Cervical Spondylosis

Cervical pain is one of the common problem among general population. However, cervical spondylosis may cause unavoidable neck pain and range limitations due to wear and tear changes in the cervical spine. This condition can further lead to dysfunction and neuro musculoskeletal symptoms. Literature suggests the use of Mulligan therapy, McKenzie exercises and Neural mobilizations in spondylosis. According to author's knowledge there is limited evidence regarding effects of specific treatment approach.

A randomized control trial will be conducted among 80 patients with cervical spondylosis having age group 40 to 60 years. The non-probability purposive sampling technique will be used to recruit on the basis of study criteria. The study settings will be Dow University of health sciences, Karachi Pakistan. After taking informed consent all the patients will be randomized into two groups (A, B). Group A will receive mulligan with upper limb movement of involved side, group B will receive McKenzie exercises and neural mobilizations. Patients will be evaluated at baseline and after four weeks of treatment by using a goniometer, numerical pain rating scale (NPRS), and neck disability index (NDI) for cervical range of motions, pain intensity and neck disability respectively. There will be twelve sessions of treatment with thrice a week.

Duration of each session will be thirty minutes. All the data will be entered and analyzed through statistical package of social sciences version 24. Descriptive analysis will be performed for both continuous and categorical data. Inferential statistics will be performed to compare pain, disability index and range of motion between group and within group. The level of significance will be considered as 0.05.

Eligibility Criteria:
Inclusion Criteria:

* 40 - 60 years old adults.
* Diagnosed and referred cases of cervical spondylosis and both males and females are included.
* Unilateral radiculopathy pain C5-C8 and T1.
* Individuals whose Spurling's and distraction test is positive.
* Patients with NPRS \> 3/10 score.
* Patients with ipsilateral cervical rotation less than 60 degrees.

Exclusion Criteria:

Individuals with history of;

* cervical or shoulder girdle trauma.
* any specific pathology or red flags (diplopia, dizziness, drop attacks, dysarthria, dysphagia)
* cervical myelopathy
* neoplastic lesions
* vertebral artery insufficiency
* upper cervical ligamentous instability,
* spondylolisthesis
* hypermobile cervical spine
* cervical fracture inflammatory
* cardiac or severe psychiatric disease.
Factors Influencing Anesthetic Drug Requirement

The main objective of the study is to analyze the influence of several environmental (i.e., timing: seasonal, circadian) and demographic conditions (i.e., age, gender, menstrual cycle) on anesthetic drug requirements (hypnotic and opiate).


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing scheduled surgery under general anesthesia, agreeing to participate in the study

Exclusion Criteria:

* Age under 18 years
* Pregnancy, breastfeeding woman
* Allergy to propofol, soybeans or peanuts
* Allergy to sufentanil, remifentanil, morphine,
* Allergy to a muscle relaxant or to any of its excipients
* Known hypersensitivity to sufentanil, remifentanil, or to other derivates of fentanyl
* History of central neurological disorder or brain injury
* Patient with dementia
* Patient with pacemaker
* Patient receiving psychotropic drugs or morphine agonist-antagonists
* Surgery on the skull and/or operating position preventing the use of a bispectral index sensor in suitable conditions