cyrilzakka/clinical-trials huggingface dataset:
Determining the Risk of Stress Fracture in IDF Soldiers Based on SNPs Identified for Osteoporosis

The study is a genetic historical cohort study in a military combat recruits - this study does not examine a specific treatment but rather examines a statistical link between medical history of traumatic fractures, clinical diagnosis of stress fractures and the presence of unique SNPs in subjects DNA.

Finding a statistically significant correlation between SNPs associated with BMD - Osteoporosis, with recruits who were diagnosed with Stress Fractures during basic and advanced infantry training. Greatest importance will be shown in the power calculation: we suggest that the P-value threshold value of the selected SNPs be adjusted downwards to a lower threshold of P \<1.0x10-3 (i.e. equal to 50 independent tests).

We will examine the presence or absence of 96 SNPs - 76 SNPs that were previously validated as significant with low BMD or Osteoporosis and 20 SNPs offered for Stress Fractures with recruits who were diagnosed with Stress Fractures during basic training (basic training lasts four months - six months) using SNP Genotyping Analysis-TaqMan Assays. The buccal swab will be taken from recruits who served for at least four months and up to six months in the IDF - Infantry Corps. Buccal swabs will be taken at a single meeting from recruits serving between 4 and 6 months in the IDF - Infantry Corps, which will be used to compare using SNP Genotyping Analysis-TaqMan Assays with the SNPs listed above. In addition, in this single meeting, the recruits will fill out a questionnaire in which they will be asked whether they experienced traumatic fracture from their youth to the time of filling the questionnaire (recruits who experienced traumatic fractures but are not diagnosed with stress fractures constitute as a control group in the research).

There will be one meeting with recruiters who served for at least four months and up to six months in the IDF - infantry. At this meeting, the recruits will be sampled with a buccal swab and fill out a questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* All participants (440) in the research are male.
* All participants (440) are recruits who serve 4-6 months in the IDF - infantry - basic training.
* 110 recruits with a stress fracture diagnosis in their medical portfolio.
* 110 recruits who have Section 4161x flaw (section Eclipse: a long bone fracture)
* 220 recruits without the aforementioned impairment clause and the above mentioned diagnosis (referred as control group).

Exclusion Criteria:

* Recruit who left the unit before conducting the research.
* A recruiter who did not complete his training due to a course that lasted over two weeks while carrying out basic training.
* A recruiter who did not complete his basic training due to absenteeism.
* A recruiter who has not completed his basic training due to problems with the service conditions.
* A recruiter who has not completed his basic training due to the reduction of a medical profile.
* A recruiter who did not complete his basic training due to a decrease in the recruitment cycle.
Longitudinal Study of Primary Osteoporosis in Shanghai Postmenopausal Women

To popularize knowledge of prevention and health care of osteoporosis.To investigate the prevalence of primary osteoporosis in community residents.

1. Objective:

   * To popularize knowledge of prevention and health care of osteoporosis.
   * To investigate the prevalence of primary osteoporosis in community residents.
2. Method:

   * The survey study included the five boroughs of six communities in Shanghai (Xuhui District 2, Pudong New Area 1, Minhang District 1, Pudong New Area 1, Jiading District 1). 10,000 participants are expected to be included.
   * Through a questionnaire and physical examination form, carries on the investigation to the 50-85 years old postmenopausal women during the 3-year follow-up period.
   * Make a survey of Bone Mineral Density,SF-36,international osteoporosis foundation ONE-MINUTE OSTEOPOROSIS RISK TEST,Markers of bone metabolism test,EQ-5D,Hepatic-renal function test and thyroid stimulating hormone level test.
   * Physicians in each community as the backbone, Shanghai University of Traditional Chinese Medicine, Longhua Hospital is responsible for personnel training.
   * Shanghai Clinical Research Center is responsible for program and data management.
   * Shanghai District Health and Family Planning Commission is responsible for coordinating the organization.

Eligibility Criteria:
Inclusion Criteria:

* Had clinical diagnosis of osteoporosis.
* With Bone Mineral Density by dual energy X-ray examination, T value \<-2.5 or less.
* Be willing to and be able to join in the study and signed Informed consent.

Exclusion Criteria:

* Excluding the impact of endocrine diseases of bone metabolism (gonadal, adrenal, parathyroid and thyroid disease), rheumatoid arthritis and other autoimmune diseases that affect the absorption of calcium and vitamin D and regulation of the digestive tract and kidney disease, multiple myeloma and other malignant diseases, long-term use of corticosteroids or other drugs affecting bone metabolism, and a variety of congenital and acquired diseases of bone metabolism.
* if they were unable to complete the study survey.
Evaluation of the Motus GI CleanUp System During Screening Colonoscopy

Motus GI is developing a single-use device that attaches to a standard colonoscope, thereby integrating colon cleansing, screening and treatment into one procedure. The device creates turbulence within the colon using water jets. The colon's fecal fluids are evacuated by the system.


Eligibility Criteria:
Inclusion Criteria:

1. Subjects in the age range of 50-69 years
2. Subjects who are considered for routine screening colonoscopy
3. Subjects with BMI within the range of 18.5-30
4. Subject is willing to sign informed consent form

Exclusion Criteria:

1. History of GI diseases or history of Colorectal cancer (personal or family)
2. Previous major abdominal surgeries
3. Medical status ASA grater or equal to 3
4. Acute GI symptoms, such as bleeding, unexplained weight loss, inflammatory bowel disease (IBD).
5. Patients taking anticoagulants (e.g., Coumadin, Heparin, Clopidrogrel)
6. Life-threatening condition
7. Subjects who are unable or unwilling to cooperate with study procedures
8. Severe Diverticula
Effects of Ultrasound-guide Hypertonic Dextrose Injection for Chronic Subacromial Bursitis

The aim of this study is to investigate the echoguide hypertonic injection and compared steroid injection in subacromial bursitis patients about clinical and ultrasound image presentation.

Subacromial bursitis is one of the major causes of chronic refractory shoulder pain. It can cause patients with shoulder pain when shoulder exercise and heavy lifting and limiting the range of motion. It can also influence the sleep quality due to pain symptoms of the shoulder. Usually, these patients had limited response to medication and physical modality. Steroid injection was often adopted for intervention, but the adverse effects should be considered. Therefore, prolotherapy was taken as an alternative treatment for chronic subacromial bursitis. It involves the injection of small volumes of an irritant agent, most commonly a hyperosmolar dextrose solution, at the lesion site. Hyperosmolar dextrose appears to be the most commonly used agent today. The aim of this study is to investigate hypertonic injections in subacromial bursitis patients about clinical and ultrasound image presentation. The investigators conducted a double-blinded randomized controlled trial for 60 participants with chronic shoulder pain for 3 months with subacromial bursitis. In the study group, the echo guide 20% dextrose water was injected into the lesion site, and the control group received the echo guide steroid injection. ROM, SPADI, VAS, x-ray, and ultrasound data were obtained at baseline. At weeks 2, 6, 12, ROM, SPADI, VAS, and ultrasound data were evaluated. The ANOVA and independent t-test are applied for analysis by SPSS 20.0 with a P value less than 0.05 as statistical significance.

Eligibility Criteria:
Inclusion Criteria:

* Aged more than 20 years old with diagnosis of chronic supraspinatus tendinosis by ultrasound and clinical shoulder pain lasting for more than 3 months.

Exclusion Criteria:

* History of shoulder fracture and operation, with frozen shoulder or full thickness ruptur of rotator cuff, steroid, or hyaluronic acid, or platelet rich plasma (PRP) injection during the period of intervention and following up.
Coronary MDCTA With Iopamidol Injection 370

Determine the validity and compare the visualization of arterial segments obtained with 3 doses of iopamidol to determine dose for further investigation in future trials.


Eligibility Criteria:
Inclusion Criteria:

* Provide informed consent
* At least 30 years of age
* Weight less than 250 lbs
* Known or suspected coronary artery disease and suspected to have significant coronary artery stenosis
* Undergo MDCTA scan
* Undergo coronary angiography within 2 weeks of MDCTA scan

Exclusion Criteria:

* Hx of hypersensitivity to iodinated contrast agents
* Known or suspected hyperthyroidism or pheochromocytoma
* Renal impairment
* History of coronary artery stent placement or bypass grafts
* Unstable
* Pregnant or lactating
Diagnostic Accuracy of Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular Lesions of the Thyroid

As many as 70-85% subjects diagnosed with a follicular lesion on biopsy and undergoing surgery will have benign lesions verified by histopathology after surgery.

Currently there is no method of pre-operatively diagnosing benign follicular lesions, as a result these subjects will have had surgery for diagnosis of a benign lesion.

The aim of this study is to see whether shear-wave elastography, a new ultrasound technology can help pre-operatively diagnose benign follicular lesions. If successful, a lot of patients will not need surgery for the diagnosis of a benign lesion.

The main goal of this study will be to evaluate the diagnostic accuracy of a new ultrasound technology, shear-wave elastography (SWE), for the diagnosis of malignancy in follicular lesions. Participants who have been diagnosed with a follicular lesion on thyroid biopsy and are scheduled for thyroid surgery will be eligible to participate. All participants will undergo a detailed ultrasound examination prior to their surgery. The results of the ultrasound will be compared with histopathology after surgery to test the diagnostic accuracy of SWE.


Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with a Follicular Neoplasm on fine needle aspiration biopsy
* Patients \>18 years of age

Exclusion Criteria

* None
The Validation of a CAD Screening Algorithm Based on Facial Photos in Community Population

The purpose of this study is to evaluate the effectiveness of a coronary heart disease screening algorithm based on facial photos in community population.


Eligibility Criteria:
Inclusion Criteria:

* Community population with a pre-test probability greater than 5% for coronary artery disease

Exclusion Criteria:

* Prior percutaneous coronary intervention (PCI)
* Prior coronary artery bypass graft (CABG)
* The history of heart failure
* With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
* Other situations which make patients fail to be photographed
Testing Familial Self-affirmation for Smoking Cessation

Evidence suggests that affirming the self can help people to make changes in their health behavior. Typically, people affirm a personally-important value, but evidence suggests that affirming the values of family ("familial self-affirmation") might exert stronger effects. The aim of the present study is to examine the effects of familial self-affirmation versus standard self-affirmation versus a control group on smoking cessation.


Eligibility Criteria:
Inclusion Criteria:

* Smoker

Exclusion Criteria:

* Non-smoker
* Unable or unwilling to complete questionnaire
Evaluation of Salivary RNAs in the Presence of an Adnexal Mass of Ovarian Origin

OVAmiARN is a multicentre, prospective, longitudinal, non-interventional, observational study carried out in 8 obstetrics and gynecology departments in France; in order to describe the evolution of salivary miRNA expression between the pre-operative and post-therapy visits according to the type of mass. In time, the clinical application will be to significantly reduce the time to diagnosis and improve the care pathway for ovarian adnexal mass.

The study population consists of patients with an ovarian adnexal mass diagnosed by clinical examination and imaging (pelvic ultrasound and/or MRI) and requiring surgical management in routine care.

The patients concerned by the study will be managed without modification of the care pathway, nor modification of the therapeutic indications, nor modification of the diagnostic or follow-up examinations (imaging or biology) necessary according to the context, which are carried out according to the recommendations of the HAS, CNGOF.

In this study, the management and follow-up of patients :

* Are not imposed by the study: the doctor remains free to make medical prescriptions (treatments and examinations) and to determine the interval between consultation visits,
* Are not modified in comparison with the usual follow-up, except for the performance of the Collection of saliva


Eligibility Criteria:
Inclusion Criteria:

* Patient over 18 years of age,
* A patient with an ovarian adnexal mass diagnosed by clinical examination and imaging and likely to be ovarian cancer, a borderline tumour or a benign cyst,
* Patient with an indication for surgery
* Patient has dated and signed the consent form,
* Patient affiliated to the healthcare system,

Exclusion Criteria:

* Pregnant patient
* Patient infected with human immunodeficiency virus (HIV),
* Patient with significant difficulties in reading or writing the French language.
* Patient with another diagnosed cancer
* Patient with a history of cancer less than 5 years old
Eletriptan Pharmacokinetics In Korean Males

The hypothesis of this study is that Korean subjects have similar Pharmacokinetics (PK) characteristics to those seen in other populations.


Eligibility Criteria:
Inclusion Criteria:

* healthy male subjects, 18-55 years old
* Body Mass Index (BMI) of 17.5 to 30.5 kg/m2
* provide informed consent

Exclusion Criteria:

* blood pressure \>140/90 mm Hg
* any condition possibly affecting drug absorption
* positive urine drug screen
Effect of Anesthesia on Expression of Programmed Death-1 and Programmed Death-1 Ligand in Breast Cancer

Surgery is first-line treatment for solid tumors. However, surgical trauma-induced physiologic stress has been demonstrated to facilitate metastasis and recurrence in different types of cancer. It has been reported that the PD-1/PD-L1 pathway could be activated by surgical stress. Hence, we instigate the effect of anesthetic technique on expression of PD1 and PD1 ligand.

The cellular immune response plays a central part in postoperative clearance of tumor cells. T lymphocytes and natural killer (NK) cells are two predominant cytotoxic effector cells that are the major components of antitumor immunity. In mouse models, proliferation of T lymphocytes in response to surgical trauma is defective . Programmed death-1 (PD-1) belongs to the CD28 receptor superfamily. It is an inhibitory receptor, and its expression is upregulated on activated leukocytes, resulting in an inhibited immune response. PD-1 interacts with two ligands: programmed death ligand-1 (PD-L1, also referred to as B7-H1) and programmed death ligand-2 (PD-L2, also known as B7-DC). PD-L2 is expressed mainly on activated dendritic cells (DCs) and macrophages, whereas PD-L1 is distributed widely. In addition to immune cells, some subsets of tumor cells also express PD-L1 to escape from immunosurveillance. It has been reported that the PD-1/PD-L1 pathway could be activated by surgical stress. Hence, we instigate the effect of anesthetic technique on expression of PD1 and PD1 ligand.

Eligibility Criteria:
Inclusion Criteria:

* patients scheduled for breast cancer surgery

Exclusion Criteria:

* compromised immune function (such as infection with the human immunodeficiency virus, immunodeficiency, or treatment with corticosteroids, immunosuppressive drugs, or chemotherapy)
* ASA \> III
* age\> 70 years old.
* patients refusal to the procedure.
* Infection of the skin at or near site of needle puncture.
* Coagulopathy .
* Drug hypersensitivity or allergy to the studied drugs.
* Central or peripheral neuropthy .
* Pre-operative opoid consumption ( within 24 hours preoperative )
* Anomalies of the vertebral column .
Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism

The aim of the study is to investigate how the retina adapts to different metabolic challenges, e.g. chronic systemic hypoxia, hyperglycemia, special training conditions or diets as well as transient changes in the content of oxygen and glucose in the blood.


Eligibility Criteria:
Healthy individuals

Inclusion Criteria:

* Healthy volunteers.
* No known systemic or ocular disease.

Exclusion Criteria:

* Any systemic or ocular disease.

Patients with diabetes

Inclusion criteria:

* Diabetes mellitus
* No intraocular disease other than conditions attributable to diabetes.

Exclusion criteria:

* Intraocular disease other than conditions attributable to diabetes.
* Systemic conditions which might contraindicate hyperoxic stimulation.
Neural Biomarkers of Electroconvulsive Therapy Response

In the proposed study, the investigators will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry. Our study will recruit patients who are beginning treatment with bilateral electroconvulsive therapy (N=75). Our design will be longitudinal where patients will be followed up until their 8th week electroconvulsive therapy clinically. The primary measure of interest will be the slope of clinical change estimated with mixed effect modeling (see Approach). Secondary measures will be the cognitive performance change between baseline and the 8th week electroconvulsive therapy time point.


Eligibility Criteria:
Inclusion Criteria:

1. current positive symptoms rated ≥4 (moderate) on one or more of these BPRS 53 items: hallucinatory behavior, unusual thought content, suspiciousness, conceptual disorganization;
2. has failed at least one trial of treatment with antipsychotic drug, lasting 6 weeks in duration,
3. competent and willing to sign informed consent;
4. for women, negative pregnancy test and agreement to use a medically accepted birth control method; and
5. Diagnostic and Statistical Manual (DSM)-IV diagnosis of schizophrenia, schizoaffective or schizophreniform disorder.

Exclusion Criteria:

1. serious neurological or endocrine disorder;
2. any medical condition which requires treatment with a medication with psychotropic effects;
3. significant risk of suicidal or homicidal behavior;
4. cognitive (MMSE ≤ 23) or language limitations that would preclude subjects providing informed consent;
5. contraindications to treatment with electroconvulsive therapy;
6. contraindications to magnetic resonance imaging (e.g. pacemaker)
The Effect of Water Intake on Glucose Regulation

There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis.

In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation


Eligibility Criteria:
Inclusion Criteria:

BMI 27.5-35

Exclusion Criteria:

* BMI \<27.5 or \>35
* high physical activity
* diabetes
* impaired liver or kidney function
* cardiovascular disease
* weight change of more than 3 kg in the past month
* pregnancy
* previous surgery on digestive tract (except appendectomy)
* fluid balance will be exclusionary such as
* serotonin re-uptake inhibitors.
Whey Protein, Resistance Training, and Changes in Body Composition

The objective of this project is to determine the effect of 9 months of progressive resistance training with daily whey protein supplements on the body composition (changes in muscle and fat) in young adults. The investigators hypothesize that those individuals who receive whey protein supplements will have larger gains in muscle and larger losses of fat tissue in response to resistance training compared to those who receive supplements of soy or carbohydrate.

Healthy men and women will be recruited to participate in 9 months of supervised resistance training (3 days/wk) and will be randomized to one of three daily supplement groups: Whey protein, soy protein, or carbohydrate control. Body weight, muscular strength and endurance, and resting blood pressure will be assessed at baseline, 3, 6 and 9 months. Body composition will be assessed at baseline, 3, 5, 7, and 9 months. A sub-sample (N = 17 per group, assessed at baseline and 9 months) will be randomly selected for muscle samples of the upper leg to determine changes in the size of muscle fibers, and chemical factors associated with muscle growth. Blood samples will be obtained from sub-sample participants to assess changes in glucose and fat metabolism, as well as other chemicals likely to promote or inhibit muscle growth. We will also assess changes in daily energy expenditure and the use of fuel to produce energy (carbohydrate, fat, protein) that may result from the intervention. We hypothesize that those individuals who receive whey protein supplements will have larger gains in muscle and larger losses of fat tissue in response to resistance training compared to those who receive supplements of soy or carbohydrate.

Eligibility Criteria:
Inclusion Criteria:

* BMI 25-39.9
* must be 18- 30 years old
* sedentary
* no medications
* stable weight for at least 3 months

Exclusion Criteria:

* Tobacco/Drug user
* metabolism altering medication
* gain/lost 10lbs in the last 3 months
* current exerciser