cyrilzakka/clinical-trials huggingface dataset:
Impact of Job Related Activities on Female Physiotherapist and Dentist During Internship Year

Response of hand grip, pinch grip and body composition to type of effort between female physiotherapist and female dentist at internship year.

Fifty physiotherapist and fifty dentist females will be selected from faculty of physical therapy and faculty of dentistry at Badr University in Cairo BUC, both at internship year, and will be assigned into two groups. Group A consists of fifty physiotherapist females will participate in this group and will be assessed at the beginning of the study and after 6 months of clinical work. Group B consists of fifty dentist females will participate in this group and will be assessed at the beginning of the study and after 6 months of clinical work. Digital hand dynamometer will be used to assess hand grip strength and InBody device will be used to assess changes in body composition at the beginning and the end of the study.

Eligibility Criteria:
Inclusion Criteria:

1. Fifty physiotherapist females and fifty dentist females at internship year.
2. Their age will be ranged from 21 to 24 years old.
3. They are medically stable and consented to participate in the study.
4. They are able to follow instructions.

Exclusion Criteria:

1. History of any pathological disease-causing disorder in metabolism such as thyroid gland disorder.
2. History of muscular or neurological disorder.
3. Using any hormonal treatment.
4. Following any diet modification method.
5. Severe emotional stress.
Effects of Cognitive Training on Chemotherapy-Induced Cognitive Impairment in Colon Cancer Patients Undergoing Treatment(Chemobrain) in Oncology Patients With Colon Cancer Undergoing Active Treatment

Introduction: With the increasing survival rate in colon cancer, as a result of technological and biomedical advancements, it is essential to thoroughly study the secondary symptoms related to the oncological disease process. One of the most common and underestimated symptoms is cancer-related cognitive impairment (CRCI).

Objective: To evaluate the efficacy of a cognitive training program in controlling CRCI in individuals with colon cancer undergoing active treatment.

Methodology: A randomized controlled clinical trial with two parallel groups: an intervention group (IG) and a control group (CG). The study population will include individuals newly diagnosed with colon cancer. A sample size of 50 participants has been estimated, with 25 in each group, to detect a difference of 2.95 points or more in the MoCA cognitive impairment questionnaire. All participants will receive an educational leaflet based on the new WHO guidelines, which recommend specific measures to reduce the risk of cognitive impairment. In addition to receiving this informational leaflet, the IG will participate in a cognitive training program (CT) focused on everyday cognition (EC) individually. Each participant will receive a dossier with 80 intervention sessions divided into four training periods (P1-P4), each containing 20 activities. Each period will last for one month. Baseline and 4-month post-intervention evaluations will be conducted for both groups, measuring sociodemographic and clinical variables, as well as study-related cognitive impairment variables: Cognitive function (MoCA test), Everyday Cognition (PECC), Anxiety (Hamilton), Functionality (LB), Sleep Quality (PSQI), Quality of Life (ECOG), and Subjective Memory Complaints (FACT-COG).

Impact: The results of this study could lead to the design of specific cognitive interventions and the establishment of protocols for colon cancer patients undergoing active treatment, helping them manage one of the most underestimated symptoms in this patient population-CRCI-whose incidence is increasing due to the improved survival rates in this disease.


Eligibility Criteria:
Inclusion Criteria:

Being an adult (18 years or older). Having a recent pathological diagnosis of newly diagnosed colon cancer and starting oncological treatment.

Being fully capable of performing daily functions. Willingness to voluntarily participate in the study and signing the informed consent.

Exclusion Criteria:

Lack of literacy skills or significant language comprehension deficits. Having a diagnosis of a Central Nervous System tumor or participating in another cognitive stimulation program.

Having a clinical diagnosis of a neurocognitive disorder as defined in the DSM-V.

Withdrawal Criteria:

Dropping out of the program or not completing the final evaluation.
The Prediction of Anastomotic Insufficiency Risk After Colorectal Surgery (PANIC) Study

The Prediction of Anastomotic Insufficiency risk after Colorectal surgery (PANIC) study aims to establish a machine-learning-based application that allows for accurate preoperative prediction of patients at risk for anastomotic insufficiency after colon and colorectal surgery.

Anastomotic insufficiency leads to clinical strains for patients, and significantly increases morbidity and mortality. On average, hospital stay is extended by 12 days while healthcare-related expenses are increased by 30,000 USD when patients suffer from an anastomotic leak. In experienced centers, the approximated incidence of anastomotic insufficiency is 3,3% for colon and 8.6% for colorectal procedures. Multiple subgroups of patients with increased risk for anastomotic leaks have been described in previous publications. Meticulous preoperative recognition of patients with increased risk for anastomotic insufficiency is clinically beneficial, as it would permit improved ressource preparation, enhanced patient education and superior surgical decision-making. However, it is often difficult for clinicians to balance the plethora of crucial risk factors for anastomotic leaks for a single patient. Machine learning methods have been exceptionally effective at incorporating various clinical variables into one unified risk prediction model. To the authors' best knowledge, there does not yet exist a credible prediction model or a conclusive prediction score for anastomotic insufficiency after colon and colorectal anastomosis. The aim of the Prediction of Anastomotic Insufficiency risk after Colorectal surgery (PANIC) study is to establish and externally validate an efficient machine-learning-based prediction tool based on multicenter data from a range of international centers.

Eligibility Criteria:
Inclusion Criteria:

* Patients who underwent colon or colorectal anastomosis for neoplasia, diverticulitis, mesenterial ischemia, iatrogenic or traumatic perforation, or inflammatory bowel disease

Exclusion Criteria:

* age \< 18
* recurrent colorectal cancer
* peritoneal carcinomatosis or unresectable metastatic disease at time of bowel resection
* informed consent not obtainable
* follow-up \< 6 weeks after surgery
* no reversal of and ostomy
Persistence of Antibody Response to N. Meningitidis Group C in Children

Persistence of Antibody Response to N. meningitidis Group C in Children


Eligibility Criteria:
Inclusion Criteria:

* healthy children

Exclusion Criteria:

* previous ascertained or suspected disease caused by N. meningitidis
* previous significant acute or chronic infections
* any other serious disease
The Impact of Cigarillo Warnings on Purchasing

The purpose of this study is to determine whether different cigarillo warning formats (pictorial, FDA-proposed text-only, current Surgeon General text-only) reduces demand for cigarillos. A previous study has identified that pictorial cigarillo warnings are perceived as more effective, but more information is needed on their impact. This study will address this issue by randomizing participants to see different cigarillo warning formats on cigarillo products within an online experimental tobacco marketplace. Participants will be cigarillo users who are ages 21-35.

Warning labels on tobacco products convey the health risks and discourage use. Warnings are even more effective when they contain images that depict the health consequences. However, little is known about the impact of cigarillo warnings, including pictorial warnings, on consumer behavior. The Experimental Tobacco Marketplace (ETM) task examines the effects of regulations on tobacco purchasing in the context of a complex tobacco marketplace. This project aims to address the gap in the knowledge about cigarillo risk communication by providing information on best practices for cigarillo warnings. Identifying effective cigarillo warnings is important to inform policy and guide research on effectively communicating risk to ultimately decrease use and tobacco-related morbidity and mortality.

Eligibility Criteria:
Inclusion Criteria:

* Current cigarillo users: used cigarillos at least one time per week in the past month
* Members of the Kantar Media panel

Exclusion Criteria:

* Non-English speakers
* Non-current cigarillo users
* Not members of Kantar Media
Clinical Evaluation of Two Daily Disposable Lenses in Neophytes

The purpose of this study is to evaluate the performance of two daily disposable contact lenses in a population of neophytes (new wearers).


Eligibility Criteria:
Inclusion Criteria:

* No previous contact lens experience or attempts to try contact lenses (neophytes).
* Currently wearing spectacles or needing vision correction in both eyes.
* No older than 45 years of age.
* Able to achieve visual acuity of at least 20/40 in each eye with study lenses in the available parameters.
* Interested in wearing contact lenses.
* Willing to wear study lenses for at least 8 hours/day, at least 5 days/week.
* Other protocol-defined inclusion/exclusion criteria may apply.

Exclusion Criteria:

* Eye injury or surgery within twelve weeks prior to enrollment.
* Pre-existing ocular irritation that would preclude contact lens fitting.
* Previous corneal or refractive surgery.
* Currently enrolled in any Clinical Trial.
* Other protocol-defined inclusion/exclusion criteria may apply.
Effect of Curcumin as Nutraceutical in Patients of Depression

The purpose of this study is to find the effect of commonly used nutraceutical curcumin ( extract of Curcuma longa, commonly called 'Haldi' in Hindi) in patients of depression.


Eligibility Criteria:
Inclusion Criteria:

* Depression as diagnosed under DSM-IV Axis I Disorders.
* Score greater than 7 but less then 35 on the 17-item Hamilton Depression (HAM-D) Scale at screening.
* The patient has relative(s) to care for him/her
* Informed consent obtained from the patient or relative

Exclusion Criteria:

* Scores greater than 2 on the "suicide" item of HAM-D, or history of suicide attempt(s) in the past 12 months.
* Current suicidal or homicidal risk, as determined by the investigator.
* Clinically significant liver disease (such as hepatitis, cirrhosis, etc); or clinically significant elevation of liver enzyme tests (two times the upper limit of normal.
* History of seizure disorder (other than febrile).
* Patient who has had monoamine oxidase inhibitor , any selective serotonin reuptake inhibitor or any other antidepressant in last 15 days
* Any of the following DSM-IV diagnoses current (within past 3 months) schizophrenia, schizo-affective, or other psychotic disorder; bipolar disorder; current panic disorder or obsessive compulsive disorder; history of psychotic features of affective disorder (mood congruent or incongruent)
* Patient with history of untreated or unstable thyroid disorder
* Failed to respond to at least two adequate antidepressant trials (defined as 6 weeks or more treatment with either greater than or equal to 150 mg imipramine, or tricyclic equivalent), or greater than or equal to 60 mg of phenelzine, or MAOI equivalent, or greater than or equal to 100 mg of sertraline, or its SSRI equivalent.
* Have had other investigational drugs within 30 days or other psychotropic medication within 21 days.
* Known allergy or hypersensitivity to the study medications.
* Receiving psychotherapies which are specifically designed to treat depression, eg, interpersonal psychotherapy during the study period.
* Mental retardation or cognitive impairment, or any disorder that might interfere with their ability to give consent or follow study procedures and requirements.
* In case of female patients, Abstinence or effective method of contraception throughout the study
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)

The goal of this research is to develop better tools for diagnosing illness of the feet and legs of people who have diabetes. Investigators will use thermal videos of the foot to aid in the refinement of a system designed to detect signs of diabetic peripheral neuropathy (DPN). The team of investigators will also look at diabetic eye disease and how it might relate to diabetic foot disease.

This study focuses on further development and testing of a microvascular functional imaging system, a computer-based system for screening thermal video images, designed to detect biomarkers of diabetic peripheral neuropathy (DPN). Additionally, severity levels of diabetic retinopathy (DR) will be compared with those of DPN.

All participants in this study will undergo foot exams, thermal imaging of the foot, and standard retinal imaging. These non-invasive assessments will be performed at an initial study visit. Some of the participants will be offered additional study visits. One of the additional visits involves a standard nerve conduction velocity assessment by a neurologist, the other involves a DPN exam by a podiatrist.

Portions of the study take place at University of New Mexico Health Sciences Center (UNM HSC). The research utilizes services of the Clinical Translational Science Center (CTSC).

The study is approved by University of New Mexico Health Sciences Center's Human Research Review Committee (HRRC), which coordinates and supports the activities of the three federally mandated Human Research Review Committees (HRRCs) responsible for reviewing and approving all human research.

Eligibility Criteria:
Inclusion Criteria:

• Must be non-diabetic or diagnosed as diabetic for at least 5 years

Exclusion Criteria:

history of chemotherapy

* surgery below the knee within the last 2 years
* fractures below the know within the last 2 years
* history of stroke
* body mass index (BMI) greater than 35
* history of heart failure
* peacemaker or implantable cardiovascular defibrillator
* high blood pressure (over 180/100)
* end-stage renal (kidney) disease or renal (kidney) transplant
* peripheral edema greater than 2+ (swelling of the feet or hands)
* diabetic foot ulcers
* foot sores
* Raynaud's phenomenon
* tobacco use within the last month.
* treatment with glucocorticoids, including:

  * beclomethasone
  * betamethasone
  * budesonide
  * cortisone
  * dexamethasone
  * hydrocortisone
  * methylprednisolone
  * prednisolone
  * prednisone
  * triamcinolone
Effect of Nutritional Formula Supplementation on Growth Rate of Growth Hormone (GH) Treated Children With Growth Hormone Deficiency (GHD) After the Second Year of Therapy

The Proposed study is a double blind, randomized, placebo controlled study The aim of the study is to evaluate the effect of combined Growth Hormone (GH) treatment \& nutritional formula supplementation versus GH \& placebo on growth parameters in 64 children with Isolated Growth Hormone Deficiency (IGHD) after the 2nd year of GH treatment.

In this trial GH is a background treatment (non-investigational medicinal product. Participants may be treated with any of the commercial GH products approved in Israel for the indication of IGHD.

Participants will be randomly assigned either to the intervention group or the placebo control group. Randomization for the two study groups will be made in a ratio of 1:1. Both participants and study team will be blinded to the type of treatment that each patient will receive during the study. The randomization will be done according to gender and tanner stage.

Participants in the intervention groups will be treated with the study formulas and participants in the control group will be treated with a placebo low caloric formulas (Powder added to water) The study will continue for 6 months of intervention versus active placebo, with additional 6 months (an extension period), in which participants at both groups, the intervention and the placebo, will be offered to continue their participation in the study with the active study supplement.


Eligibility Criteria:
Inclusion Criteria:

* GH treatment for at least 24 months due to IGHD. Confirmed diagnosis of GHD as determined by at least one GH stimulation test, defined as a peak GH level of ≤ 10 ng/ml
* Boys: testicular volume \< 8ml; Girls: breast ≤ Tanner 3
* weight SDS \< 0
* BMI SDS \< 50 precentile for age and gender
* Signing inform consent forms

Exclusion Criteria:

* Other indication for GH treatment.
* Bone age: boys\>13.5, girls\>11.5.
* Any known morbidity: chronic disease dysmorphic syndromes, bone diseases, organic brain diseases, neurological disease, past or current malignancy, chronic cardiac, renal or pulmonary problems, metabolic disorders.
* Any known gastrointestinal problem including absorption problems.
* Any chronic treatment with medication that might affect appetite, weight or growth (for example steroids) except from Ritalin use
* Any eating disorders and/or psychiatric disorder
Safety and Efficacy of Andecaliximab (GS-5745) in Adults With Moderately to Severely Active Ulcerative Colitis

The primary objectives of this study are as follows: 1) To evaluate the efficacy of andecaliximab to induce endoscopy, rectal bleeding, and stool frequency (EBS) clinical remission at Week 8 (Cohort 1); 2) To evaluate the efficacy of andecaliximab to maintain EBS clinical remission at Week 52 (Cohort 2); and 3) To evaluate the safety and tolerability of andecaliximab. The study will consist of 3 parts: Induction Phase (Cohort 1), Maintenance Phase (Cohort 2), and an optional Extended Treatment Phase.


Eligibility Criteria:
Key Inclusion Criteria:

* Ulcerative Colitis (UC) confirmed on endoscopy
* Moderately to severely active UC (Mayo Score 6-12)
* May be receiving oral 5-aminosalicylate (ASA), oral corticosteroid, azathioprine, 6-mercaptopurine (MP), or methotrexate
* Treatment failure with at least one of the following agents received: corticosteroids, immunomodulators, tumor necrosis factor-alpha (TNFα) antagonists, vedolizumab

Key Exclusion Criteria:

* Diagnose of Crohn's disease or indeterminate colitis
* Pregnant or lactating females
* Any chronic medical condition (including, but not limited to cardiac or pulmonary disease, alcohol or drug abuse)
* Exhibit severe UC / clinically significant active infection
* History of malignancy in the last 5 years

Note: Other protocol defined Inclusion/Exclusion criteria may apply.
The Clinical Efficacy of Laryngeal Mask Airway in Elderly Patients: Comparison With Young Adults

There are some differences between elderly and young adult patients regarding the anatomy of upper airways. Elderly patients have larger upper airways than young adult patients at all pharyngeal levels as revealed by CT. Another study explained that there is a progressive descent of the larynx and epiglottis with aging, which lengthens the upper airway and possibly makes it more likely to collapse.

The aim of this study is to compare the clinical efficacy of laryngeal mask airway (LMA) in elderly patients with young adults. In this study, the investigators will measure the ease of insertion, success rate of insertion, the time of insertion, oropharyngeal leak pressure, gastric leak pressure, fiberoptic position and intraoperative complications of the classic LMA.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged 20-40 and 65-85years
* ASA status 1-2
* Undergoing minor urologic surgery or lower extremity surgery
* Undergoing general anesthesia using classic LMA

Exclusion Criteria:

* Predicted difficult airway
* Increased risk of aspiration
* Gastroesophageal reflux
* Neuromuscular disease
* Significant acute or chronic lung disease
Cigarillo Warnings Image Sorting Study

The goal of this study is to examine the impact of repeated exposure to cigarillo warnings on cigarillo users' intentions and behaviors for cigarillo smoking. Eligible participants will be randomized to one of three experimental conditions that will vary based on cigarillo warning format.

For 4 weeks, participants will participate in an image-sorting task where they will be asked to sort a set of \~18 cigarillo packages into flavor categories determined a priori by the research team (e.g., Mint, Fruit, Dessert).

At the end of the study, participants will be notified of the purpose of the study and provided links to resources with information about the harms of cigarillo smoking and cessation.

The study will be conducted in an online survey, working with Qualtrics research company, who will program the survey, recruit and screen participants, and administer the survey.


Eligibility Criteria:
Inclusion Criteria:

* Current cigarillo user-used cigarillos at least one time per week in the past month
* Recruited through Qualtrics Research Services

Exclusion Criteria:

* Not recruited through Qualtrics Research Services
* Non-English speaking
Passive Cooling Versus Blanket-Roll III on The Myocardial Function of Asphyxiated Neonates

Studying the effect of passive versus Blanket roll III modality of therapeutic hypothermia (TH)on myocardial function of asphyxiated neonates through using tissue Doppler (TD).

A clinical trial study of 100 Gestational-age-matched asphyxiated cooled neonates will divided into two groups, 50 in each group for comparison the myocardial function using passive cooling and BLANKET ROLL III as modality of TH.

Eligibility Criteria:
Inclusion Criteria:

* Evidence of perinatal/intrapartum hypoxia, as indicated by at least one of:

  * Apgar score of less than or equal to 5 at 10 minutes
  * Needing mechanical ventilation or ongoing resuscitation at 10 minutes
  * PH in cord blood gas is less than 7.00 or a base excess worse than or equal to minus 12 mmol /L on cord/arterial/venous/capillary blood gas obtained within 60 minutes of birth.
* Evidence of moderate or severe encephalopathy.
* Greater than or equal to 35 weeks gestational age.
* Birth weight greater than or equal to 1800 g.
* Able to begin cooling before 6 hours of birth.

Exclusion Criteria:

* Congenital cyanotic heart disease.
* Multiple congenital anomalies.
* Birth asphyxia's babies after start of cooling with cardiovascular instability.
Effects of Group Vs. Home-Based Combined Exercise-Diet Program In Childhood Obesity: A Randomised Controlled Trial

The aim of this study was to compare the effect of a hospital group-based vs. home-based combined exercise-diet program for the treatment of childhood obesity.


Eligibility Criteria:
Inclusion Criteria:

* caucasian
* overweight/obese

Exclusion Criteria:

* Subjects with severe obesity (z-score above 2.5)