cyrilzakka/clinical-trials huggingface dataset:
5 Versus 10 Sprays of Lignocaine for Pharyngeal Anaesthesia During Bronchoscopy

Flexible bronchoscopy is one of the most widely performed procedures for diagnosis of various bronchopulmonary diseases. Most patients tolerate the procedure well although cough is often reported as a distressing symptom. It is likely that the acceptance of bronchoscopy would be significantly improved with control of cough.

Topical lignocaine is administered during bronchoscopy for local anaesthesia. There is uncertainty regarding the adequate dose of lignocaine sprays for pharyngeal anaesthesia during flexible bronchoscopy. This study would help to determine the optimal dose of lignocaine sprays for pharyngeal anaesthesia during flexible bronchoscopy.

For all patients meeting the inclusion criteria, the demographic profile including age, sex, weight and the type of procedures performed during bronchoscopy shall be recorded. A written informed consent will be obtained from all participants. Enrolled patients will be randomized to receive either 5 or 10 sprays of 10% lignocaine to the pharynx. This will be followed by the standard topical anesthesia procedure followed in our institution involving 5ml of 2% lignocaine gel into the nostril. Transnasal flexible bronchoscopy will be performed with additional 1% lignocaine administered as "spray as you go" method. This will be given as 2 ml aliquots- with similar volume in both groups as baseline. Procedure shall be performed with administration of sedation using Midazolam and Fentanyl if required. Primary outcome will be assessed by noting the operator rated overall procedure satisfaction as a VAS scale score.

Eligibility Criteria:
Inclusion Criteria:

* All adults ≥ 18 yrs of age undergoing flexible bronchoscopy

Exclusion Criteria:

* Uncontrolled hypertension Systolic Blood Pressure \>180 mm Hg
* Symptomatic coronary artery disease
* Pregnancy
* Not giving informed consent for the procedure
* Hypoxemia (oxygen saturation \[by pulse oximetry\] \< 92% with Fio2 of ≥ 0.3
* Bronchoscopy performed through an artificial airway
Growth Hormone For Poor Ovarian Reserve Patients in ICSI Trials

Effect of Growth Hormone Adjuvant Therapy on ICSI Trials For Poor ovarian Reserve Patients

To study the effect of growth hormone as adjuvant treatment on the outcomes of ICSI trials in poor ovarian reserve patients.

Eligibility Criteria:
Inclusion Criteria:

According to Bologna criteria (((at least two )))of the following features must be present:

1. Advanced maternal age (40years).
2. A previous poor ovarian response with 3 oocytes retrieved after conventional stimulation
3. An abnormal ovarian reserve test (ORT)

   * antral follicle count (AFC)\<7 or
   * anti-Müllerian hormone (AMH)\<1.1ng/ml.

Exclusion Criteria:

1. Any known contraindications to the approved fertility drugs.
2. Any contraindications to growth hormone, pregnancy (to be ruled out and documented before GH treatment)

4- Hydrosalpinx 5- Uterine malformations or abnormal uterine cavity. 6- Basal FSH more than 17 IU. 7- Abnormal karyotyping 8- Partner with severe male factor 9- Uncontrolled endocrinopathies: DM, hyperthyroidism, hypothyroidism.
CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation

The purpose of this research is to determine whether treatment with the study drug dapagliflozin for 6 months affects pulmonary capillary wedge pressure (PCWP) at rest and during exercise in adults with failing Fontan circulation.


Eligibility Criteria:
Inclusion Criteria

Subjects are eligible to be randomized in the study only if all the following inclusion criteria and none of the exclusion criteria apply:

1. Signed informed consent prior to any study specific procedures
2. History of Fontan procedure
3. Male or female subject
4. Age ≥ 18
5. Symptoms of dyspnea (NYHA II-III) with no non-cardiac or ischemia explanation
6. Undergoing clinically indicated cardiac catheterization
7. Elevated pulmonary capillary wedge pressure (PCWP) during exercise (≥25 mmHg) ascertained at Visit 1. Patients that have consented to study procedures but do not meet this invasive criterion will be considered as screen failures and will not be randomized.

Exclusion Criteria

1. Type I diabetes
2. Any of the following medications: Insulin or Pramlintide, Sandostatin, Akeega (abiraterone acetate), Growth Hormone (Somatogrogon-GHLA), Lithium, Chloroquine, Hydroxychloroquine, Thioctic acid (alpha lipoic acid), Empagliflozin or Canagliflozin
3. Recent hospitalization (\<30 days) or revascularization (\<90 days)
4. Significant valvular heart disease (≥moderate stenosis, \>moderate regurgitation)
5. Significant Fontan obstruction with resting SVC-IVC gradient \>4 mmHg
6. Primary cardiomyopathy (such as amyloid)
7. Dyspnea due to primary lung disease or myocardial ischemia in the opinion of the investigator
8. Severe anemia (hemoglobin \<9 gm/dl)
9. Severe kidney disease (estimated GFR\<30) or liver disease
10. Women of childbearing potential not willing to use a medically accepted method of contraception OR who are currently pregnant (confirmed with positive pregnancy test) or breast feeding.
11. History of serious hypersensitivity reaction to dapagliflozin
12. Subjects on dialysis
13. Subjects with severe liver disease with history of decompensation including ascites or encephalopathy or variceal bleeding
14. Single ventricle heart disease without Fontan palliation
15. Those with a history of Fontan takedown
Behavior Management Using Audiovisual Tools

The aim of the study was to assess whether the behavior, anxiety, and pain of pediatric patients during dental treatment improves when a cartoon film is viewed or a videogame is played as methods of distraction.

Each patient required a minimum of 2 visits for restorative treatment in a mandibular quadrant and had undergone a previous restorative dental experience. All parents or guardians of the children who participated in the study were informed about the study before enrolment, and gave their voluntary consent. Each visit lasted approximately 35 minutes and involved restorative treatment in a mandibular quadrant with an alveolar nerve block. The parents were not present in the operating room during the treatment. The maximum time between the 2 treatment sessions was 2 weeks. Before the start of each treatment session, as a part of the standard process of a paediatric dental visit, the child was given an explanation as to what the visit would comprise, with the aim of interrupting the treatment as little as possible. The children knew at the beginning of the first appointment (control) that they would be able to watch a movie or play a videogame during their next visit.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 4-9 years.
* Patients who required a minimum of 2 visits for restorative treatment.
* Patients who had previously shown disruptive behavior (Frankl Behavior Rating Scale 1 or 2) during dental restorative treatment or pulp therapy.

Exclusion Criteria:

* Patients with reduced audiovisual capabilities.
* Patients with psychological disorders.
Lung Structure-Function In SurVivors of Mild and SEvere COVID-19 Infection: 129Xe MRI

In this study the Investigators aim to deploy UTE and HP 129Xe MRI for structural and functional evaluation of persistent lung abnormalities in COVID-19 survivors.

What is COVID-19? The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused when an individual is infected with the SARS-CoV-2 virus. This infection can result in pneumonia involving the small airways and alveoli (the tiny air sacs at the end of the airways that help oxygen get into the blood). COVID-19 can cause damage to the lungs, making it hard to breathe without medical help. To understand what is happening to a patient's lungs, doctors may use imaging tests such as chest x-rays or CT Scans (computed tomography). However, these types of tests may not tell the Investigators the whole story.

What is the purpose of the study? Led by The Hospital for Sick Children (SickKids), this study is being done to determine if MRI (magnetic resonance imaging) scans can tell the Investigators more about the lungs of people who had COVID-19. The Investigators will use a special type of MRI where participants breathe in a special gas (hyperpolarized xenon-129) before they have the MRI. This gas will help the Investigators to see' the lungs. The advantage of MRI scans is that there is no radiation involved in these types of images.

What is involved? In this study, participants will have an MRI of their lungs. The Investigators will examine these MRI scans to see if the Investigators can identify any changes in the structure or the function of the lung. If the Investigators do find any changes, they will see how these changes relate to other tests that have been conducted or other parts of the clinical story.

The participants will be asked to come to SickKids for 3 study visits. A fourth visit will be conducted via telephone. These visits will span over 3 years. Each study visit will take about 4 hours. If the participant is unable to attend one of the in-person visits, they will be given the option for a phone/virtual visit instead.

Eligibility Criteria:
Inclusion Criteria:

* Consent provided
* Aged 12-70 years old
* Meets MRI screening criteria
* Diagnosed with COVID19, documented by positive COVID19 test (Nasopharyngeal swab or saliva swab) and are within 3 months post recovery\*.

  * Recovery from COVID19 is defined as asymptomatic for at least 2 weeks prior to study visit 1 and screen negative based on SickKids guidelines.

Exclusion Criteria:

* Pregnant or lactating\*
* A cold or flu within the last 2 weeks
Predictors of Early Success From Circumferential Compression STITCH Meniscal Repairs

This is a retrospective study of meniscal tear repairs at least one-year post repair status. All patients were treated with Ceterix NovoStitch devices. The primary objectives of this study are to assess the clinical repair success rate via reoperation and PROs at greater than 12 months.

The study is a retrospective, non-randomized, single-group assignment, open-label study of repairs of meniscal tears status post repair. The following clinical efficacy endpoints will be evaluated at greater than 12 months:

* Reoperation rate
* Validated patient-reported outcomes measures
* Contribution of the following retrospective covariates on failure and outcomes when available: Type of tear, Location of tear (lateral versus medial), Chronicity of symptoms, Nature of tear (degenerative versus traumatic), Length of tear, Patient age, Patient gender, Length of rehabilitation protocol, Performance of trephination, Inclusion of biologic enhancement, Meniscal repair alone versus meniscal repair combined with ACL reconstruction.

Eligibility Criteria:
Inclusion Criteria:

* Able and willing to give consent by voluntarily providing written informed consent in accordance with governing Institutional Review Board (IRB)/Independent Ethics Committee (IEC) requirements, local regulations, and Health Insurance Portability and Accountability Act (HIPAA) Authorization (or equivalent if locally applicable)
* In the opinion of the Investigator are able to comply with study-required follow-up

Exclusion Criteria:

* Post-operative interval \<1year
* Concurrent bony fractures
* Post-operative reinjury (except the meniscus)
* Pre-operative arthritis grade 3 or higher on modified outerbridge
* Knee surgery prior to meniscus repair surgery
* Any kind of infection
Efficacy of Muscle Energy Techniques in the Treatment of Chronic Non-specific Low Back Pain

Chronic Non-Specific Low Back Pain is characterized as a tension, soreness and stiffness. Various studies, defined MET as a manual medicine treatment procedure that involves the voluntary contraction of the subject's muscle in a precisely controlled direction, at varying levels of intensity, against a distinctly executed counterforce applied by the therapist.

Chronic Non-specific LBP is located in region below lower costal margins and above inferior gluteal margins with or without any referred pain in legs, an essentially non-attributable to any specific cause. It may lasting for more than 7-12 months and affect individual over a long period of time once in a lifetime at least. METs is useful in increasing extensibility and range of motion of various joints and provides good results in the patients with back pain. These techniques are used as the treatment of weakened muscles, restricted joints, reducing pain reliving muscle tension \& spasm, \& increased strength of the muscle. MET is a verstile, safe, gentle technique traditionally used to address muscular strain, PAIN, local edema and joint dysfunction. It was reported that post isometric relaxation is considered a highly effective therapy for back dysfunction patients.

Eligibility Criteria:
Inclusion Criteria:

1. Age: 18 - 45 years
2. Gender : both genders
3. Low Back Pain of more than 3 months duration
4. ODI Score between 20-80%
5. BMI: 25-29 Kg/m2
6. VAS: Initial Pain Score \> 3
7. Pain Localized to Lower Lumbar Region
8. Decreased Lumbar ROM

Exclusion Criteria:

1. Red Flag Signs of Low Back Pain (Metabolic Bone Disease, Malignancy, Cardiovascular Disorder, Pregnancy)
2. Patient with Paraesthesia or Numbness
3. Disturbed Reflexes (Hypo/Hyper Reflexia)
4. Motor Weakness
5. H/O Low Back Surgery
6. H/O Recent Trauma \< 2 Months
7. H/O Rheumatoid Arthritis, Osteoporosis and Fracture
8. Joint hyper mobility.
9. Psychological Mental Disorders
Deep Learning of Anterior Talofibular Ligament: Comparison of Different Models

The purpose of this study is to study the injury of the anterior talofibular ligament by deep learning method and compare a variety of different deep learning models to establish a deep learning method that can accurately identify and grade the injury of anterior talofibular ligament, and obtain a model with better recognition and grading effect.

1. Recognition and segmentation of anterior talofibular ligament based on DenseNet. Densenet was used to recognize the axial T2-fs image, and the image level was the most typical one. The labelimg program based on Python was used to locate the coordinates of the anterior talofibular ligament and then imported into Python for learning. All the data were divided into a training set (70%, and then 30% of the training set was selected as the verification set). The remaining 30% was used as the test set to evaluate the accuracy of model recognition. After identifying the anterior talofibular ligament, the local clipping and amplification are carried out to remove the redundant information. Finally, input the result to the next step.
2. Establishment and comparison of various deep learning models: four deep learning models were established and compared in this study, namely VGG19, AlexNet, CapsNet, and GoogleNet. The models using image fitting alone and those combining with clinical physical examination data were compared for each deep learning model. The diagnostic efficiency between models was expressed by the ROC curve, including AUC, F1 score, etc. the ROC curve was further analyzed by t-test, Delong test, and other statistical methods. In this study, the data were divided into a training set (70%, 30% in the training set as the validation set), and the remaining 30% as the test set to evaluate the classification accuracy.

Eligibility Criteria:
Inclusion Criteria:

1. Without any treatment before imaging examination;
2. MR of ankle joint was performed within 3 months before operation and the image quality was good;
3. Arthroscopic operation was performed in our hospital and the operation records were complete.

Exclusion Criteria:

1. history of ankle surgery, history of cancer or previous fractures.
2. Unclear image, serious artifact or incomplete clinical data.
Disruption of Circadian Rhythm and Healthcare-related Infection in Patients With Severe Trauma

Circadian rhythms, which play crucial roles in physiology, are emerging as important regulators of specific immune functions. Hospitalization in intensive care unit leads to a deep impairment of circadian rhythm. Infection is a frequent event during ICU hospitalization.

The investigators hypothesis is that in trauma patients the lack of circadian rhythm variations is associated with the occurrence of infection. The primary aim of the study is to assess the circadian variations of plasma Bmal1 in the occurrence of healthcare related infection during the 30 days after inclusion. The secondary aims are to assess the plasma expression of circadian genes (Clock, Cry1, Per3, and Rev-erba), the production of cytokines in plasma, and the concentration of cortisol, according to the occurrence of an infection.


Eligibility Criteria:
Inclusion Criteria:

* Trauma patients with an injury severity score \> 15, requiring mechanical ventilation for at least 24 h during the first 48 h and an arterial catheter.

Exclusion Criteria:

* Pregnant and lactating women
Combined Sono-electro-magnetic Therapy for Treatment of Refractory Chronic Pelvic Pain Syndrome

Treatment of chronic pelvic pain syndrome (CPPS) is challenging for patients and physicians once conventional therapies fail.

We hypothesize that combined sono-electro-magnetic therapy can improve refractory CPPS in men. In addition, we postulate that combined sono-electro-magnetic therapy as well as placebo therapy has a significant effect on brain activity detectable by functional MRI.


Eligibility Criteria:
Inclusion Criteria:

* CPSS III
* symptomatic \>3 months
* NIH-CPSI total score =/\>15
* NIH-CPSI pain =/\>8

Exclusion Criteria:

* post void residual \>100mL
* urinary tract infection
* urethral stricture
* prostate cancer
* age \<18 years
* claustrophobia
* pacemaker, neurostimulator, insulin / pain pump
A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine (0462-087)

A study to provide evidence supporting the benefit of Rizatriptan in patients who have an inadequate response to sumatriptan.


Eligibility Criteria:
Inclusion Criteria:

* Patient has a history of migraine with or without aura for 1 year or more with 2-8 moderate or severe migraine attacks per month
* Patient generally does not respond to treatment with sumatriptan
* Patient of reproductive potential agrees to remain abstinent or use one method of highly effective birth control (i.e. IUD, condoms, hormonal contraceptive, diaphragm, vasectomy) for the duration of the study
* Patient is able to complete paper diary

Exclusion Criteria:

* Patient is pregnant or breast feeding or excepts to become pregnant during the study
* Patient has history of mild migraine attacks or migraines that usually resolve spontaneously in less than 2 hours
* Patient has basilar or hemiplegic migraines
* Patient is unable to distinguish between migraine attacks from other types of headaches
* Patient has more than 15 headache-days per month
* Patient was greater than 50 years old at age of migraine onset
* Patient has failed to respond to 3 or more triptans
* Patient has a repeated history of failing to respond to or tolerate rizatriptan
* Patient uses opioids as primary migraine therapy
* Patient uses daily opioids
* Patient has a history of Cerebrovascular Accident (CVA) or other significant cardiovascular disease
* Patient has uncontrolled hypertension
* Patient has a history of neoplastic disease
* Patient is taking a serotonin reuptake inhibitor (SSRI or SNRI) where the dose has changed 3 months prior to screening
* Patient has a history of drug or alcohol abuse
Socioeconomic Profile and Patient Satisfaction Assessment

The aim of the study was to evaluate the socioeconomic patient's profile and their level of satisfaction in the general dental practice clinic. A cross-sectional quantitative study was accomplished with 80 patients assisted at the referred service. A solely-applied questionnaire was used regarding the following aspects: structure and environment, fear and anxiety, reliability, empathy and commitment, resolutivity and quality of the accomplished services. It was observed that the assisted patients' profile consisted predominantly of a female sample (71,2%), that completed the medium learning (31,2%) and/or that didn't finish the fundamental level (26,2%). Moreover 50% of them presented a family income of 1 to 2 minimum salaries and 41,2% were unemployed. As the quality of the rendered technical service, nearly 70% of the users considered it great, as well as the clinic's structure and environment. Regarding the satisfaction with to the received treatment, 76,2% of the interviewees gave the maximum score of 10 and 95% would recommend the attendance to others. It is concluded that the patients are satisfied with the clinical attendance accomplished by the students in the general practice dental clinic at UNIFOR, in what refers to its technical and functional quality.


Eligibility Criteria:
Inclusion Criteria:

* Patient registered in Academic of Information System (SIA),
* Patient assisted in the general dental clinic,
* To have 18 years or more or to be parents accompanied,
* Agree with research participation.

Exclusion Criteria:

* To be urgency patient,
* To be the first day of attendance at clinic.
The Efficacy of the Alcooquizz App to Reduce Hazardous Alcohol Consumption

New technologies offer potential ways to provide and deliver preventative interventions. With respect to unhealthy alcohol use, offering people tools to assess and manage their risk at any given time using their smartphone may represent an additional opportunity to disseminate preventative interventions. Nevertheless, there is a lack of knowledge on the acceptability and efficacy of smartphone applications for unhealthy alcohol use. Alcooquizz, a smartphone app, has been previously evaluated using a before/after design without randomization, with participants reporting reductions in drinking over time. The current trial proposes to conduct an RCT, comparing reductions in alcohol consumption between participants provided access to Alcooquizz to a no intervention control.

Participants will be recruited through Amazon's MTurk crowdsourcing platform. Potential participants identified as problem drinkers based on an initial survey will be invited to complete another survey in 6 months time. Those who agree to be followed-up will be randomized to be provided a link to download the Alcooquizz app or to a no link control condition. At six-months post-baseline, the MTurk portal will be used to send invitation emails that contain a link to the follow-up survey that asks about their drinking and their impressions of the app. The primary hypothesis to be tested is that participants receiving access to the Alcooquizz app will report a greater level of reduction in number of drinks in a typical week between the baseline survey and six-month follow-up as compared to participants in the no information control condition.


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or over
* A score of 8 or over on the Alcohol Use Disorders Identification Test (AUDIT)
* Typically consumes 15 or more drinks per week,
* Willingness to complete a 6-month follow-up survey

Exclusion Criteria:

-