cyrilzakka/clinical-trials huggingface dataset:
Validity of Computed Guided Technology in Proper Placement of Intermaxillary Fixation Screws in Mandibular Fractures

A randomized clinical study that aims to assess the validity of the use of computer guided technique in the proper placement of IMF screws in mandibular fractures

Fractures of the facial skeleton involving the teeth bearing segments can lead to disruption of the dental occlusion, and difficulties with speech and mastication. The temporary fixation of opposing jaws is called maxillomandibular fixation and is usually secured through placement of IMF screws and wires. The correct placement of IMF screws can be challenging. Such planning may make use of radiographs and computed tomography scans. Knowledge of safe zones in the facial skeleton for screw placement through the use of pre-operative 3-dimensional planning may prevent some of the cited complications. The use of a custom made surgical guide for IMF screw placement has the potential to reduce operation time, optimize screw position, and minimize injury to dental roots and important anatomical structures. Aim: The aim of this study is to Assess the use of computed guided technique in the proper placement of IMF screws in mandibular fractures. Materials and Methods: This clinical study will be conducted on 20 patients who will be equally and randomly distributed into 2 groups: Group A: 10 patients will be treated with 3D guided placement of IMF screw. Group B: 10 patients will be treated with Conventional placement of IMF screws.

To assess the accuracy of IMF screws placement in each group.

Eligibility Criteria:
Inclusion Criteria:

* Patients suffer from recent mandibular fractures that requires fixation
* Dentulous patients
* Medically fit for surgery (ASA I AND ASA II)

Exclusion Criteria:

* Edentulous patients
* Patient with bone pathosis
* patients with primary and mixed dentition
* pathologic mandibular fracture
Assessment of the Minimal Residual Disease in DLBCL From Cell-free Circulating DNA by NGS

This is a prospective descriptive monocentric study whose purpose is to describe the clonal evolution of the mutational pattern in cfDNA of a cohort of patients with Diffuse Large B-Cell Non-Hodgkin Lymphomas (DLBCL) before, during and after standard treatment

To determinate and to describe the clonal evolution, 30 DLBCL cases with available matched tumor DNA and plasma will be collected and analyzed by routinely applicable next generation sequencing (NGS) at the time of diagnosis, at mid treatment, at the end of treatment and at 12 months after diagnosis.

Eligibility Criteria:
Inclusion Criteria:

* Age up to 18 years old
* With a diagnosis formally established of DLBCL or transformed straightaway follicular lymphoma or 3B grade follicular lymphoma or Burkitt-like lymphoma
* Eligible to a treatment by immunochemotherapy like R-CHOP, R-ACVBP or R-CHOP like
* First line of treatment
* Being able to benefit from standard extension assessment ( Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and bone marrow biopsy with a bone marrow aspiration)
* Written informed consent
* Tumor biopsy used for diagnosis available

Exclusion Criteria:

* Patient who cannot receive polychemotherapy like R-CHOP, R-ACVBP, or R-CHOP like
* Patient who cannot benefit from standard extension assessment and follow-up by with Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET)
* Pregnant or breast-feeding woman
* Guardianship, curatorship
* Patient who cannot follow the medical procedures of the study for geographic, social, psychological,linguistic or physical reasons
Single Injection of Dexamethasone for Acute Bronchiolitis in Young Children

The purpose of this study was to determine whether a single intramuscular injection of dexamethasone decreased the duration of symptoms of acute bronchiolitis in young children.

Acute bronchiolitis is an infection of the lower respiratory tract causing inflammation of the small airways, leading to bronchiolar obstruction. Corticosteroids are frequently prescribed as anti-inflammatory drugs. The usefulness of corticosteroids for this disease remains controversial, despite many randomized controlled trials (RCTs). Recently, a meta-analysis and systemic review showed significant improvement in clinical symptoms, length of hospital stay and duration of symptoms in children with this disease after treatment with various regimens of systemic corticosteroids.

Dexamethasone is a long acting corticosteroid with biologic half-life ranging from 36-72 hours. A single dose of dexamethasone has been the standard recommendation for the treatment of croup which has a similar pathophysiology without evidence of adverse effects. Furthermore, there is no previous report of this single dosage form of dexamethasone for the treatment of acute bronchiolitis in young children.

Eligibility Criteria:
Inclusion Criteria:

* Aged 4 weeks - 24 months
* Has the first episode of wheezing within 7 days
* Has evidence of viral infection
* Requires hospital admission; criteria for admission include one of the following: age \< 3 months; respiratory rate \> 60 breaths/minute for age \< 12 months or 50 breaths/minute for \> or equal to 12 months; oxygen saturation in room air \< 95% and apathy or refuses feeding.

Exclusion Criteria:

* Initial admission to intensive care unit
* Initial requirement for endotracheal intubation or mechanical ventilation
* A previous history of intubation
* A known history of asthma or response to the first dose of beta2 agonist nebulization
* A history of prematurity
* A history of bronchopulmonary dysplasia or chronic lung disease
* Underlying congenital heart disease or immunodeficiency
* Receives treatment of any form of corticosteroids within 2 weeks
* Has contraindication to corticosteroid treatment
Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy

Perioperative blockage of beta-adrenoreceptors is widely used in cardiac and non-cardiac surgery to reduce the rate of cardiovascular complications. Several randomized-controlled studies and meta-analysis showed that esmolol reduces the incidence of myocardial ischemia and arrhythmias in cardiac surgery as well as enhances postoperative cardiac performance. No studies assessed the influence of esmolol in patients with hypertrophic obstructive cardiomyopathy undergoing cardiac surgery.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years
* Signed informed consent
* Patient with hypertrophic obstructive cardiomyopathy undergoing surgery under cardiopulmonary bypass

Exclusion Criteria:

* History of adverse effects on esmolol
* Urgent/emergent surgery
* Administration of esmolol in 30 days before randomization
* Participation in other randomized trial during same hospitalization
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Postural Control in Lowlanders

Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on postural control

Baseline measurements including the assessment of the center of pressure during 30s, the cerebral oxygen saturation and a sharpened Romberg test will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the base camp of the Atacama Large Millimeter/Submillimeter Array (ALMA) telescope station located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 8 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing testing as described above at the first and the last day at 5050m. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 8 day altitude sojourn participants will return to the Santiago area (520 m) for a 6 day recovery period.

A second altitude sojourn with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.

Eligibility Criteria:
Inclusion Criteria:

* born, raised and currently living \<800m
* No overnight stay at altitudes \>1500 m 4 weeks before the study

Exclusion Criteria:

* Previous altitude intolerance to altitude \<3000 m
* Pregnancy
* Health impairment, which requires regular treatment
Evaluation of Bioflex Crowns Using the Hall Technique in Primary Molars

The goal of this randomized controlled clinical trial is to to evaluate the clinical performance and radiographic success of BioFlex crowns versus SSCs using Hall Technique in primary dentition. The main questions it aims to answer are:

Does bioflex crowns have the same clinical performance and radiographic success of stainless steel crowns when placed using Hall Technique?

will bioflex crowns alter the occlusal vertical dimensions or affect the tempomandibular joint?

If there is a comparison group: Researchers will compare bioflex crown to stainless steel crown to see of the bioflex crowns are effective as stainless steel crowns when placed using hall technique

Participants will recieve bioflex crown and stainless steel crown according to randomization and they will be followed up immediately after treatment, after 2 weeks , after 1 months , after 3 months , after 6 months and after 12 months

The study will be a double-armed randomized controlled clinical trial, with parallel design. A total of 74 pediatric patients aged 4-8 years will be selected from the Pediatric Dentistry Outpatient Clinic, Faculty of Dentistry, Alexandria University, Egypt. Participants will be allocated into 2 groups according to the type of crown used. Group I (study group) will be treated with BioFlex crowns using Hall technique, while Group II (control group) will be treated with the SSCs using Hall technique. Clinical and radiographic success of both crowns will be assessed. The function of the temporomandibular joint (TMJ) will be evaluated using the Helkimo Clinical Dysfunction Index (Di) and the AAPD questionnaire. The Occlusovertical dimension measurements will also be evaluated using the Van der Zee and Van Amerongen method. Plaque and gingival health will be recorded using plaque and gingival indices, and the satisfaction level of the child will be assessed using the Facial Image Scale (FIS), while the satisfaction level of parents will be assessed using questionnaire.

Eligibility Criteria:
Inclusion Criteria:

- Primary molar teeth with occlusal or occlusoproximal carious lesions into dentin (ICDAS codes: 3-5).

Exclusion Criteria: Teeth will be excluded if they exhibit:

* Clinical or radiographic signs of irreversible pulpitis.
* Presence of fistula or abscess.
* Spontaneous pain.
* Pulp exposure.
* Bruxism.
* Pathologic mobility (identified by gently rocking the tooth buccolingually using tweezers).
Continued Study of Artificial Vision: Evaluation of the BrainPort® System and Investigation of Visual Ambulation

The purpose of this study is to evaluate the use of an artificial vision system called Brainport system in blind patients To investigate visual, and oculomotor (eye motion) mechanisms involved in the use of the Brainport system.

The prevalence of blindness in the US adult population is 0.8% and ranges from about 3/10000 to 15/10000 in children. Data from world health organization show that about 500,000 children become blind each year. The annual cost of blindness to the federal government is $4 billion and the cost of a lifetime of support and unpaid taxes for a blind person is about $1 million.

There is a need to restore vision for blind patients. Research on vision restoration develops fast. There are multiple types of approaches toward producing useful artificial vision. One of them directly sends images from a video camera to the visual cortex via an electrode array that is intracranially placed on the visual cortex of blind patients. Another one surgically places an electrode array beneath the retina for patients whose optic nerves are still healthy. Both of them require major surgery and have high risks, and neither is available for routine clinical application.

The one that is non-invasive and easy to use is called the BrainPort® system. The BrainPort® system is manufactured by Wicab, Inc. It is commercially available and affordable to any consumer. This system is a novel, bionic, non-invasive, vision bypass system that conveys environment images from a spectacle-frame-mounted video-camera to the brain via an electro-tactile tongue array. The electro-tactile stimulation delivered by the tongue-array placed on the tongue allows users to interpret the images of objects in their camera's visual field.

Eligibility Criteria:
Inclusion Criteria:

* Less than 25 years of age and be able to cooperate for full study protocol
* Have a clinical diagnosis of blindness (light perception or worse), or 20/20 vision corrected or otherwise.
* Have completed a complete ophthalmic evaluation.
* Patients recruited must be able to undergo the training to use the BrainPort® system.
* Sign informed consent (family) or assent (patient).

Exclusion Criteria:

* Have any neurologic disease, developmental delay, congenital genetic syndromes, congenital organ malformation, malformation syndromes or metabolic disease.
* Be on any medications known to affect the visual system
ICS/LABA Combination With Integrated Dose Counter and Smartphone APP to Improve Asthma Control

Poor adherence to asthma controller medication may link to poor asthma outcome. A metered dose device with built-in dose counter helps physicians to monitor drug compliance in asthma patients. Mobile-phone based self management opens a window for better asthma control. The present study aims to investigate the relationship between the adherence to controller medication of combined inhaled corticosteroid/long acting beta2-agonists, assessing by integrated dose counter, and the level of airway inflammation and asthma control. Moreover, the investigators also use a new asthma self-management Apps to enhance drug compliance. With the application of the new, easily available tools, the investigator expect to increase adherence rates, and hence, to reduce airway inflammation and improve the level of asthma control.

The study will be conducted as a prospective, observational, open labeled, randomized trial in a single center (Taipei Veterans General Hospital). After screening, the enrolled patients will be randomized to either routine care or Smartphone self management group. In the routine care group, the patient will be treated as routine practice as a real-world setting. No additional intervention will be done. In the Smartphone self management group, an asthma self management Apps (My asthma App, GlaxoSmithKline, Chinese version, or Line), which provides multiple function, including health information (real-time weather condition, air pollution index) at the point-of-living, personalized health assessments (asthma control test, peak flow rate) and interactive action plans (green, yellow, and red light), and regular reminding for controller administration, will be downloaded to the participant's Smartphone. The participant will be educated to operate the Apps to improve asthma control. Participants in both groups will use identical controller (Sal/flu 2 inhalations twice daily plus as-needed rescue ventolin) and will be scheduled to follow up for 24 weeks.

Eligibility Criteria:
Inclusion Criteria:

1. Symptomatic asthmatics free of controller medication for at least 3 months
2. Aged from 20 to 70 years
3. Life-long smoking index \< 10 pack-years

Exclusion Criteria:

1. COPD, clinically overt bronchiectasis, lung cancer, active tuberculosis, or other known specific pulmonary disease.
2. A chest X-ray indicating diagnosis other than asthma that might interfere with the study.
3. Major disease abnormalities are uncontrolled on therapy.
4. Alcohol or medication abuse.
5. Patients had lower respiratory tract infections or received systemic steroid in the 4 weeks prior to the commencement of study.
6. Unable or unwilling to comply with all protocol
7. Unable to use Smartphone
Benefits of Group Psychotherapy Programs in the Treatment of Obesity

Obesity has reached pandemic proportions in recent years, affecting not only the physical health, but also the mental health, of obese people. According to Spain's National Health Survey 2011-12, the prevalence of obesity in the adult population of Spain was 17%, having increased by 2.5% since 2006. Therefore, a constant and worrying increase in the prevalence of obesity is being observed, which is having a great impact, both individually, in terms of health and quality of life, and socially, inter alia, by raising health expenditure due to increased morbidity.

In this context, the desirability of a comprehensive approach that includes psychological intervention in attending obese patients (Rev Cochrane, 2006), has been given greater prominence. Paying attention to the emotional and psychopathological aspects related to obesity has proven to be an action that could have positive impact on obesity intervention models.

The aim of this project is to measure, through a clinical trial, the efficacy of a psychotherapy group program for obesity patients who are attended by the consulting endocrinologist at the Infanta Leonor Hospital (Madrid). The impact of body mass index, psychological wellbeing, psychopathology and quality of life of two experimental study groups will be compared, one a control group of patients that follows the standard treatment, the other an experimental group that follows not only the standard treatment, but also the psychotherapy group intervention program.


Eligibility Criteria:
Inclusion Criteria:

* Age older than 18 and younger than 65.
* Body mass index of 30 or higher.
* Candidate to a specific obesity treatment.
* Accept psychological attention.
* Able to understand and consent participation.
* Able to speak, write and read in Spanish.
* Committed to assist weekly for 6 months

Non-inclusion Criteria:

* Obesity related to a non- stabilized hormonal disorder.
* Severe mental disorders requiring specific treatment resources.
* Cognitive or sensitive deficits.
* Having had bariatric surgery within last 2 years.

Exclusion criteria:

* Pregnancy during treatment
* Bariatric surgery during treatment
* Addictive disorder as a principal diagnosis.
Community-Based Care Management For Teen/Young Adult Mothers and Fathers

Teenagers who become parents often struggle with new challenges as they try to take care of their children and themselves. Programs that provide teens with support, education, and counseling may help teens to become the best parents they can be and reach their own goals. Health care providers who take care of pregnant and parenting teenagers are trying to find out what types of programs are most helpful for the physical, emotional, and social health of pregnant and parenting teenagers. The purpose of this study is to find out what kinds of activities help teens be successful as parents and achieve success in their lives.

Pregnant teenagers and teenagers who have children less than 2 weeks old and who attend either University Family Medicine, the Maryland Women's Center, Teen Tot Clinic, University Care at Edmonson Village, Weinberg Community Health Center, or Maryland General Outpatient clinics will be asked to participate in a home visiting and care management program and study. Those agreeing to participate are placed into one of two groups. One group receives a Home Visiting and Care Management Program along with their usual medical care. The other group receives only their usual medical care.

If placed into the home visiting group, the teen is given a home visitor (also called a Care Manager). The Care Manager arranges to meet with the teen every month until the teen's baby is 2 years old. The meetings last about 1 hour and usually take place in the teen's home.

The Care Manager provides 4 Core Services to the teen:

1. Baseline and ongoing monthly needs assessment for healthcare, mental health, school/job attainment, daycare, housing stability;
2. Computer Assisted Motivational Interviewing (CAMI) sessions with teen mother. In CAMI sessions, the teen answers questions on a laptop computer that assess partner relationships, sexual behaviors, \& risk for repeat pregnancy. Following the assessment, the trained Care Manager conducts motivational interviewing, a counseling technique aimed at assisting the teen to improve contraceptive and condom use, focus on goals, and promote school continuation;
3. Parenting instruction with a culturally sensitive, developmentally relevant parenting curriculum; and
4. Coordination and linkage with primary care and community partners (e.g. UMB Division of Community Psychiatry) with respect to health care, mental health care, and other services.

If the teen grants permission, we will try to contact her baby's father and invite him to participate in similar activities.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant teenagers
* Ages 12-18 years old
* \>= 24 weeks gestation
* Attending any of 5 West Baltimore prenatal care sites.
* Male partner (baby's father) if the pregnant teenager agrees to let the program contact him to invite participation.

Exclusion Criteria:

* Age \< 18 years and no parent/guardian able to grant consent.
* Male partner of a pregnant teen/teen mother if she does not grant consent to let us contact him and invite participation.
Misoprostol as a Treatment for Endometrial Polyps in Infertile Patients

Endometrial polyps are one of the main causes of infertility in women. In this work we propose an alternative, effective, economical and safe treatment: the use of misoprostol

The prevalence of uterine polyps has been estimated in the general population at 10-15%, while in infertile patients it ranges from 6-32%. Its etiology is considered as multifactorial. Polyps induce a local inflammatory response in the endometrial cavity, causing infertility. The treatment of choice considered "gold standard" is the excision by hysteroscopy, however, improvement has been shown in patients with conservative management due to the regression rate of 27%. There are no recommended drugs to provide a definitive treatment for uterine polyps. Misoprostol is a synthetic analogue derived from prostaglandin E1 that has stimulating effects on the smooth muscle fibers of the uterus, causing contractions of the myometrium, which cause endouterine evacuation. The present study shows a possible utility of misoprostol for the conservative treatment of uterine polyps.

Eligibility Criteria:
Inclusion Criteria:

* Women with uterine polyps diagnosed by endovaginal ultrasound and/or hysterosonography, female ≤ 45 years of age

Exclusion Criteria:

* Patients older than 45 years, polyps larger than 60 mm, who did not perform surveillance and/or minimum assessment 6 months after medical management
Study of Balance Reactions in a Virtual Environment Compared to a Real Environment

Validate a virtual environment by demonstrating a non modification of the characteristics of postural reaction and displacement of the body's center of pressure between a real environment and the same environment in immersive virtual reality.


Eligibility Criteria:
Inclusion Criteria:

* Healthy volunteer, men and women over 18 years old

Exclusion Criteria:

* Severe visual disorders which couldn't enable immersive virtual reality experience
* Immobilisation of one of the upper limbs (restraint splint)
* Orthopedic problems and pain in the lower limb
* MSSQ upper than 25
* Pregnant women
* Person under legal protection