cyrilzakka/clinical-trials huggingface dataset:
Virtual Reality in Reeducation : Application to Shoulder Affections

The objective of this study is to assess the interest and the efficiency of virtual reality in functional rehabilitation of shoulder pain and shoulder injuries. Participants will follow a 12-week rehabilitation program based either on exercises or on a program integrating virtual reality. Results obtained with classical rehabilitation will be compared with the one obtained virtual reality.

Fifty people will be included in the study. Then, they were randomly separated in two groups : 25 people will do the "classical rehabilitation" and the other 25 will have a treatment with virtual reality.

Each group (virtual reality and "classical rehabilitation") is going to follow 12 weeks of rehabilitation, at a rate of 2x 30 minutes per week. In "virtual reality group", each session will be divided in two parts : 15 minutes of virtual reality exercises and 15 minutes of exercises from "classical program". Exercises suggested in the classical program have been chosen among evidence based exercises described in literature.

Before the beginning of rehabilitation sessions, participants will be assessed at the Laboratory of Human Motion Analysis of the University of Liege. At this place, EMG activity of periscapular muscles (upper trapezius, lower trapezius and serratus anterior) (Delsys Trigno) , 3D scapular kinematics (Codamotion) will be assessed on the painful side when doing shoulder elevations in sagittal and in frontal planes. Maximum isometric strength will also be assessed using handheld dynamometer (MicroFet2) in 3 different positions (SeatedU90°, SeatedU125°, Prone-v-thumbs up)

This first evaluation will be done after the 12 week of rehabilitation too, with the same method.

Participants will also have to complete Dash (Disability of the Arm, Shoulder and Hand) questionnaire 3 times during the study (at the beginning, at 6 weeks and at the end of the study). Moreover, pain score will be asked to participants at each rehabilitation session.

Eligibility Criteria:
Inclusion criteria:

* unilateral scapular dyskinesis
* positive scapular assistance test and positive resistance test
* shoulder pain
* ability to play sport despite shoulder pain
* one or more positive tendinous tests

Exclusion criteria :

* traumatic history of shoulder injury in the last 6 months
* surgical history at shoulder or cervical location
* scoliosis
Muscle Energy Technique on Forward Head Posture and Cervical Mobility in Visually Impaired Children

Forward head posture is one of the most common postural deviation seen among visually impaired children and, it is characterized by hyperextension of upper cervical and flexion of lower cervical spine. These changes lead to muscle imbalance and resulting in weakness of the deep cervical flexors, shortening of the opposing cervical extensors and reduction in cervical range of motion. Muscle energy technique is a manual therapy technique using in the treatment of shortened muscles, muscle weakness, restricted joints range of motion. so this study aimed to investigate the efficacy of muscle energy technique on forward head posture and cervical mobility in visually impaired children.

subjects will be allocated according to the inclusion and exclusion criteria from different schools for visually impaired children. They will be divided randomly into study group and control group. Study group will be participated in suboccipital muscle energy technique. Control group will be participated in sham technique. The duration of treatment for both groups will be 3 times/week for 6 weeks. Autodesk AutoCAD software will be used to analyze the measured angles and CROM will be used to assess cervical mobility

Eligibility Criteria:
Inclusion Criteria:

* Visual acuity will be 6/24, 6/36 and 6/60 after correction.
* Wearing glasses more than one year.
* Craniovertebral angle \< 50°.
* Functional hearing.

Exclusion Criteria:

* Injury of cervical region (e.g: atlantoaxial instability).
* Cervical spine deformities or/disorders.
* History of previous cervical spine surgery.
* Rheumatic and congenital heart disease.
* Regular participation in any sport activities.
* Intellectual or/mental disabilities
A Study of Melatonin Concentration During Lactation

This research is being done to understand better how a mother's emotional well-being and lifestyle, such as her levels of stress, fatigue, depression, anxiety, sleep quality, and eating habits, might affect the levels of melatonin and sIgA in her breast milk.

This study aims to learn more about promoting mothers' and babies' health by studying various maternal factors. Gaining a better understanding of the connections between a mother's emotional and physical state and the quality of her breast milk could lead to new recommendations and support strategies to improve the mother's well-being.

Participants will be involved in the study during the immediate postpartum period. They will be asked to provide a 5mL sample of breast milk on day 14 postpartum between 6am and 9am. Participants will be asked to use an orange ambient light during nighttime infant care from the time they come home from the hospital up until the time of breastmilk collection to avoid harsh lighting while providing care for their baby, which may affect melatonin levels.

In addition to breast milk collection, participants will complete a series of questionnaires related to their emotion well-being and lifestyle. These questionnaires will help the research team understand how factors like stress, fatigue, depression, anxiety, sleep, and dietary patterns may be associated with melatonin and sIgA levels in breast milk. Information regarding medications and gestational age of the newborn will be collected from medical records to further assist in data analysis.

Eligibility Criteria:
Inclusion criteria:

* Possess a refrigerator with a freezer or a standalone freezer for sample storage at home.
* Ability to be contacted by telephone.
* Having internet access at home.
* Being in the immediate (0-14 days) postpartum period.
* Currently breastfeeding or planning to breastfeed, regardless of the type.

Exclusion criteria:

* Newborns with congenital malformations.
* Newborns with birth weights less than 2,500g or greater than 4,000g.
* Gestational age less than 37 completed weeks or greater than 42 completed weeks.
* Mothers hospitalized in an intensive care unit (ICU).
* Newborns hospitalized in the neonatal intensive care unit (NICU) or special care nursery (SCN).
* Mothers using sleep aids (e.g., Benadryl, Unisom, Melatonin, Valerian).
* Mothers currently being treated for pharmacologically treated mood and sleep disorders.
* Mothers with acute infections longer than 7 days postpartum. Mothers will be withdrawn from study if antibiotics are taken between 7 and 14 days postpartum.
Home- vs. Hospital-based Surgical Training

The purpose of this study was to assess the effect of training with a personal, portable laparoscopic endo-trainer (PLET) on residents' laparoscopic skills. All participants were randomised to either a home- or hospital-based PLET training group and surgical skill performance was assessed using five laparoscopic exercises. Endpoints consisted ofsubjective and objective assessment ratings as well as exercise time and qualitative data up to 12 weeks. The primary outcome was the difference in exercise time and secondary outcomes included performance scores as well as qualitative data.


Eligibility Criteria:
Inclusion Criteria:

* ≥ 18 years
* surgical resident

Exclusion Criteria:

* none
Surgical Debulking of Pituitary Adenomas

This is a randomized, multicenter trial with stratification done by a single radiologist at the coordinating center (NYU), and patients with comparable disease will be randomized to Sandostatin LAR treatment administered 1 time per month by IM injection for 3 months before (Arm A) or, for non-cured patients, after (Arm B) surgery. All patients will undergo transsphenoidal hypophysectomy. The impact of surgical debulking on responsiveness to Sandostatin LAR will be evaluated.The primary objective of this trial will be to determine whether surgery (debulking of pituitary adenomas) improves the response of patients with acromegaly to treatment with Octreotide LAR, when compared to Octreotide LAR therapy alone.

The current goal of treatment for people with acromegaly is normalization of both growth hormone (GH) and insulin-like-growth-factor-1 (IGF-1) levels. Normalization of GH and IGF-1 levels attenuates the morbidity (hypertension, cardiovascular disease, sleep apnea, increased cancer risk, arthritis) and increased mortality associated with persistent GH and IGF-1 elevation. The optimal approach to achieving these goals in patients with pituitary macroadenomas remains controversial. Available treatment modalities include transsphenoidal hypophysectomy, medical therapy (somatostatin analogues and/or dopaminergic agonists), radiotherapy, or a combination or these interventions. No randomized trials have been conducted to investigate whether surgical debulking of pituitary macroadenomas enhances the efficacy of medical therapy. This study is designed to rigorously investigate whether surgical debulking increases the efficacy of a long-acting depot somatostatin preparation, Sandostatin LAR, so that evidence-based optimal care may be offered to patients with acromegaly.

Eligibility Criteria:
Inclusion Criteria:

* Carry a diagnosis of de novo acromegaly with an elevated age and sex matched IGF-I and GH \>1ng/ml at all time points during OGTT
* Have a pituitary macroadenoma
* Have clinical changes consistent with acromegaly
* Have a single random serum hGH of 12.5 ng/ml or greater
* Both the endocrinologist and surgeon must agree that the patient's health would not be compromised by a three-month period during which time Octreotide LAR is administered.
* Patients currently on dopamine agonist who agree to discontinue medication (2-6 week washout required)

Exclusion Criteria:

* Pregnant or breastfeeding
* Documented loss of vision due to pituitary tumor
* Prior treatment for acromegaly other than dopamine agonists
* Inability to complete the protocol
* Intolerance to octreotide
TAPB vs QLBII for Kidney Transplantation Procedure

The main advantage of Quadratus Lumborum Block (QLB) compared to Transversus Abdominalis Plane Block (TAPB) is the impact on visceral pain due to the spread of the local anaesthetic agent to the paravertebral space. It may produce extensive analgesia and better pain control.

Previews studies shoved the effectiveness of TAPB in kidney transplantation procedure (KTX) by reducing opioids requirements during and after the operation. QLB was not evaluating in KTX procedure yet, but it reduced postoperative morphine requirement after cesarean section under spinal anaesthesia.

The aim of this prospective, randomised controlled, multicenter, clinical study is to compare the perioperative analgesic efficacy of QLB and TAPB in patients who had KTX under balanced (general and regional) anaesthesia.

After Bioethical Committee of Medical University of Warsaw approval, informed written consent will be obtained from all patients.

A sample size of 104 patients was calculated to obtain at list 25% reduction of fentanyl usage in QLBII group with 0,05% significance and power of 0,8. Consenting patients, scheduled to KTX procedure under general anaesthesia will be randomly assigned (1:1) according to the computer -generated randomization list with permuted blocks (block sizes: 20, 20, 24, 40) to receive 20ml of 0,25% Bupivacaine with epinephrine ipsilaterally to the operation side in QLBII or TAPB after the general anaesthesia induction and before the surgery starts. All the blocks will be performed in the supine patients position, under ultrasound guidance for both techniques. The correct spread of injectate will be confirmed with ultrasound.

Eligibility Criteria:
Inclusion Criteria:

1. Kidney transplantation procedure with anatomical urinary outlet
2. Written informed consent

Exclusion Criteria:

1. Patients' refusal
2. Known allergies to study medication
3. Inability to comprehend or participate in pain scoring scale
4. Inability to use intravenous patient controlled analgesia system
5. Anatomic, posttraumatic and postoperative deformations could possibly affect the spread of local anesthetic in transversus abdominalis plane or quadratus lumborum muscle plane.
6. Transversus abdominalis plane or quadratus lumborum muscle plane not seen in ultrasound examination.
An Open Label Trial to Evaluate the Effects of a Novel Renal Multivitamin on Inflammation and Other Biomarkers in Endstage Renal Disease Patients

The purpose of the study is to determine whether an ingestion of a new renal multivitamin supplement can have a beneficial effect on bone and mineral adn inflammation issues related to patients on dialysis.


Eligibility Criteria:
Inclusion Criteria:

* End stage renal disease patients on dialysis for at least 90 days deemed to be at low risk by the investigator for being hospitalized or have concurrent infections
* Serum phosphorous level \> 5 mg/dl
* Stable phosphate binder regimen for 2 week prior to enrollment
* Stable dose of Vitamin D for 4 weeks prior to enrollment
* Stable calcimimetic dose for 4 week prior to enrollment

Exclusion Criteria:

* patients who are pregnant
* patients who have pre existing thrombocytopenia defined as a platelet count of \<100 x 109/L
* abnormal LFTs
* baseline CRP \> 15 g/dl
* known sensitivity to any of the active ingredients
* patients who are currently enrolled in a clinical trial, or who have been in a clinical trial in the last six months
* are currently taking any immunosuppressive medications
Effects of Cognitive Training on Academic Task Performance in Attention Deficit Hyperactivity Disorder (ADHD)

Impaired WM is a central deficit in ADHD. A computerized training program, Cogmed, has been shown to increase WM capacity in children with ADHD. It is not known whether the training improves behavior associated with classroom learning, such as remaining on-task and inhibiting off- task behavior. The aim of this study is to utilize ecologically valid measures to investigate training's effect on observable ADHD behavior in conjunction with more standard measures. Subjects will be randomly assigned to a Cogmed versus an active "placebo" condition in which the tasks do not increase in difficulty level in a double-blinded fashion. The effects of the active Cogmed versus placebo computer training will be compared on measures in children with ADHD.


Eligibility Criteria:
Inclusion Criteria:

1. Age range 7-14
2. At least average academic and intellectual functioning via parent report.
3. Must have ADHD (by parent report of previous diagnosis or per telephone screening checklist - to be confirmed via interview and ratings)
4. Attentional, hyperactive or impulsive symptoms that interfere with functioning.

Exclusion Criteria:

1. Diagnosis of severe mental illness for example, psychotic, bipolar or major depressive disorder, (by history)
2. Mental retardation (by history)
3. English is not the primary language
4. Family does not have a computer
Functional Characterisation of Post-stroke Fatigue

Post-stroke fatigue is highly prevalent and disabling. However, its causes and consequences in the chronic phase are not fully understood. The aim of this cross-sectional study is to explore functional correlates of post-stroke fatigue in the chronic phase.


Eligibility Criteria:
Inclusion Criteria:

* Mini Mental State Evaluation \> 24
* Stroke \> 6 months ago

Exclusion Criteria:

* Current active infection
* Multiple stroke
* Other affection of the central nervous system
* Medication potentially inducing severe fatigue
* Hospital admission during last month
* Severe Apraxia
* Severe Aphasia
Clinical Study of CD38 CAR-T Cells in the Treatment of Hematological Malignancies

Clinical Study on the Safety and Effectiveness of CD38 CAR-T Cells in the Treatment of CD38-positive Hematological Malignancies

The CAR-T cell injection uses immune cells from healthy donors, and is the final product obtained after CAR genetic modification, cell expansion, culture, screening, preparation, sub-packaging, and release inspection. CD38 is highly expressed in myeloid leukemia, and it has been confirmed that the treatment of targeting CD38 has great potential in the treatment of CD38-positive hematological malignancies. The center intends to apply for a clinical trial of CD38 CAR-T cells to treat CD38-positive hematological malignancies on the basis of preliminary research.

Eligibility Criteria:
Inclusion Criteria:

* 1. Patients is histologically diagnosed with CD38-positive AML according to the NCCN Clinical Practice Guidelines in Oncology：Acute Myeloid Leukemia（Version 2.2021）;
* 2. The diagnosis is consistent with r/r CD38 + AML, and includes any of the following conditions:

  1. No CR was obtained after 2 courses of standard chemotherapy
  2. The first induction was CR, but the duration of CR was less than 12 months
  3. No CR was obtained after the first or multiple remedial treatment
  4. Relapse twice or more
* 3. The number of blast cells in bone marrow was more than 5% (morphology) and / or \> 1% (flow cytometry);
* 4. No active lung infection, inhaled air oxygen saturation ≥92%;
* 5. The estimated survival time is more than 3 months;
* 6. ECOG score was 0-2;
* 7. The patients or their legal guardians voluntarily participated in the trial and signed the informed consent.

Exclusion Criteria:

* 1. Patients with history of epilepsy or other central nervous system diseases;
* 2. Patients with prolonged QT or severe heart disease;
* 3. Pregnant or lactating women (the safety of this therapy for unborn children is unknown);
* 4. The patients with uncontrolled active infection;
* 5. Active hepatitis B or hepatitis C virus infection;
* 6. Previous application of gene therapy;
* 7. The proiferation rate is less than 5 times response to CD3/CD28 co-stimulation signal;
* 8. Serum creatinine \> 2.5mg/dl or ALT / AST \> 3 times ULN or bilirubin \> 2.0mg/dl;
* 9. Those who suffer from other uncontrolled diseases are not suitable to join the study;
* 10. HIV infection;
* 11. Any situation that the researchers believe may increase the risk of patients or interfere with the test results.
Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery

This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.

Stroke is one of the leading causes of motor disability. The main intervention strategy in stroke rehabilitation is to induce cortical plasticity for motor re-learning.

It has been demonstrated that electrical stimulation applied to the periphery can elicit abundant sensory afferent inputs to enhance excitability and activation area in the sensorimotor cortex. Recent evidence suggested that a new type of electrical stimulation pattern, stochastic resonance stimulation, is capable of efficiently enhancing the activation of peripheral and central nervous system. Therefore, the purpose of this study are to identify the effects of stochastic resonance electrical stimulation on neuromuscular control and proprioception, and to investigate the effectiveness of combining stochastic resonance electrical stimulation with rehabilitation program on post stroke motor function recovery.

Eligibility Criteria:
In first stage

Inclusion Criteria:

healthy adults without history of neurological disorders or limitation in range of motion for thumb ﬂexion

In the second stage

Inclusion Criteria:

1. first-ever cerebral cortical region involved chronic stroke, onset over a month
2. able to perform active grasp on the affected side with the scores of manual muscle test at least two points
3. at stable medical condition for intervention confirmed by a specialized physician.

The exclusion criteria were

1. history of other neurological disorders
2. cognitive impairment (Mini-Mental State Examination score \< 24, MMSE)29
3. unable to follow instructions
4. contraindications of ES
5. under 20 years old.
Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Normal Population

This study intends to explore the levels of MSRV expression by analyzing the levels of MSRV transcripts in blood, as well as the levels of the MSRV-Env protein in serum in the normal population. This study is important for establishing a baseline to analyze results obtained in MS patients (another dedicated study is performed in parallel in MS patients). The study will be conducted over one year in a cohort of healthy subjects. The MSRV RNA level, MSRV-Env protein levels, reverse transcriptase activity, inflammatory markers assessed by cytokines levels will be analysed to define control levels in the normal population and their variation during one year. The data obtained in this study in healthy controls will be compared to those obtained in a parallel similar study, GN-E-002, conducted in different types of MS patients.


Eligibility Criteria:
Inclusion Criteria:

* Signature of an informed consent;
* Male or female between 18 and 60 years of age.

Exclusion Criteria:

* Positive serology for hepatitis B or C or HIV;
* Acute infection at inclusion;
* Severe psychiatric disorder, neurological, inflammatory, or autoimmune disease;
* Pregnancy or breastfeeding;
* Heavy smokers i.e. more than 10 cigarettes per day;
* History of alcohol or drug abuse in the last 3 years;
* Participation in a clinical trial (within the last 3 months).
Simple Changes Weight Loss Intervention

The investigators examined feasibility and acceptability of a non-restrictive diet focused on increasing dietary fiber and lean protein for weight loss. Fifteen obese adults enrolled in a 12-week assessment which included 6 bi-weekly individual dietary counseling sessions to attain a daily goal of higher fiber (\>35 g/day) and lean protein (0.8 g per kilogram/day of individual's ideal body weight).

Participants were instructed to increase both their dietary fiber intake to 35 g/day and protein intake to 0.8 g per kilogram/day of their ideal body weight. Loss of 5% of their body weight are considered to achieve the weight-loss goal. The intervention included 6 bi-weekly, 30-minute individual dietary counseling sessions over 12-weeks. Behavioral strategies including self-monitoring, problem solving, goal setting, stimulus control, food substitution, and relapse prevention were taught to assist participants in meeting their fiber and protein goals.

Eligibility Criteria:
Inclusion Criteria:

1. interested in losing weight and have a body mass index (BMI) 30-45 kg/m2;
2. ages 21 to 70;
3. able to provide informed consent;
4. physician's approval of his/her patients to participate;
5. non-smoker (given nicotine's effect on weight suppression, on HDL, and smoking cessation's effect on weight

Exclusion Criteria:

1. clinically diagnosed diabetes, or an HbA1c ≥ 6.5%;
2. an acute coronary event within the previous 6 months;
3. pregnant or lactating;
4. plans to move out of the area within the 12-week study period;
5. diagnosis of a medical condition that precludes adherence to study dietary recommendations (e.g., inflammatory bowel disease, active diverticulitis, renal disease);
6. following a low-carbohydrate, high-fat dietary regimen such as the Atkins' Diet or participating in a weight loss program;
7. previously had bariatric surgery;
8. currently using weight loss medication;
9. diagnosis of an eating disorder (anorexia nervosa, bulimia nervosa or binge eating);
10. unable to provide consent.