cyrilzakka/clinical-trials huggingface dataset:
Body Balance Responses to Aquatic Therapy Among a Cohort of Healthy Postmenopausal Women

the aim of this study is to investigate the effect of aquatic Exercises on balance in healthy postmenopausal women .

Menopause, defined as the final menstrual period, physiologically results from the natural depletion of ovarian follicular function; a condition that translates into permanent amenorrhea (the permanent cessation of menstrual flow) generally associated with aging.

Many women have few or no symptoms, and thus, these women are not necessarily in need of medical treatment. The signs and symptoms of menopause are characterized by onset of irregular menses, hot flushes and night sweats. Menopause is also known to be associated with changes in behavior and other biological functions e.g., mood swings, anxiety, stress, forgetfulness and sleep disturbances

Eligibility Criteria:
Inclusion Criteria:

* 1) Their ages will range from 50 to 60 years.

  2) Their BMI will be less than 30 kg/m².

  3) All females will be apparently healthy postmenopausal women and walking independency.

  4) They have physical ability to participate in aquatic exercise program.

Exclusion Criteria:

* 1)Urinary or fecal incontinence. 2)Open wounds, contagious skin diseases or infective diseases. 3) Vascular thrombi. 4) Cardiac insufficiency. 5) Fracture in last year in lower limb.
Determination of Immune Phenotype in Glioblastoma Patients

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Despite intensive research efforts and a multimodal management that actually consists of surgery, radiotherapy and chemotherapy with temozolomide, the prognosis is dismal. The aim of the current observational study is to determine immune phenotypes in individual patients with GBM at the time of diagnosis and to correlate tumor size, location (imaging), tumor properties (isocitrate dehydrogenase - 1 (IDH-1), o6-methylguanine-DNA-methyltransferase (MGMT), epidermal growth factor receptor (EGFR) mutation status, etc.) with clinical data, such as progression free and overall survival, Karnofsky index (progression free survival (PFS),overall survival (OS), Karnofsky score( KFS)), with blood immune phenotypes, biomarkers, and immune histochemical results of tumor infiltrating lymphocytes, macrophages, myeloid derived suppressor cells (MDSC), etc.. The different immunological phenotypes could predict a positive response to specific immunological therapeutic strategies and select the individual therapeutic plan for an individual GBM patient.


Eligibility Criteria:
Inclusion Criteria:

* adult glioblastoma multiforme

Exclusion Criteria:

* pregnancy, unable to give consent
Implementation of a Diagnostic Workflow for Personalized Diagnosis of Nephrotic Syndrome

Nephrotic syndrome (NS) is a clinical picture common to several diseases resulting from damage to podocytes and glomerular filtration barrier. Currently, there is limited consensus regarding the diagnostic pathway and management of the specific etiology. Some patients show complete response to first-line steroid therapy (steroid-sensitive nephrotic syndrome, SSNS), especially in children and young adults. The prognosis of this group is generally favorable. In contrast, patients unresponsive to steroids (steroid-resistant NS, SRNS) frequently undergo immunosuppressive therapies, which are burdened with numerous side effects. Resistance to treatment is associated with a high likelihood of progression to chronic renal disease (CKD) and kidney failure (ESKD). Recent evidence suggests that immunological mechanisms (including permeabilizing factors) are involved in the pathogenesis of post-transplant NS recurrence and SSNS.

Providing patients with NS with a correct diagnosis is the cornerstone of personalized medicine, reducing morbidity and side effects of therapies, ensuring their appropriate prescription, and slowing or preventing progression to ESKD.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of NS (SSNS, SRNS, or NS relapsed after transplantation regardless of initial response to steroid therapy)
* Age below 40 years at disease onset
* Availability of clinical information
* Signed informed consent form

Exclusion Criteria:

* Age at onset above 40 years
* Kidney biopsy proving lesions other than FSGS and MCD
Integrative Korean Medicine Treatment for Pediatrics After Traffic Accident: Retrospective Chart Review Study and Survey

A retrospective chart review study and survey research to verify the efficacy and safety of integrative Korean medicine treatment for pediatric traffic accident patients.

This study is a long-term follow-up observational study targeting patients aged 0 to 6 years who visited any of the seven branches of Jaseng Hospital of Korean Medicine for outpatient and inpatient treatments after traffic accident injuries. After obtaining consent from the guardians, retrospective collection of medical records and computer data for traffic accident patients aged 0-6 will be conducted, followed by prospective surveys through Google Forms or phone interviews with the guardians. This data will be used for causal and factor analysis.

Eligibility Criteria:
Inclusion Criteria:

1. Patients aged 0 to 6 years who have visited the institution for symptoms caused by a traffic accident and have received at least one session of integrative Korean medicine treatment as inpatient or outpatient care.
2. Among the patients described in 1, those whose guardians understand the purpose and content of the research and consent to participate in the study.
3. Among the patients described in 1, those whose guardians have the communicative ability, as well as the mental and physical capacity to respond appropriately to surveys.

Exclusion Criteria:

1. Cases where only consultation was provided or only Western medical treatment was administered at our institution.
2. Other cases deemed unsuitable for study participation by the researcher.
3. Patients with a history related to the chief complaint.
Virtual Hepatic Venous Pressure Gradient (vHVPG) With CT Angiography (CHESS1601)

This is a prospective, multi-center trial conducted at 1 Guangzhou and 2 Beijing centers designed to determine the diagnostic performance of virtual hepatic venous pressure gradient (vHVPG) (investigational technology) by anatomic computed tomographic angiography (CTA) for non-invasive assessment of the clinically significant portal hypertension (CSPH) in patients with compensated cirrhosis. Direct hepatic venous pressure gradient (HVPG) measurement by means of catheterization of a hepatic vein with a balloon catheter is the gold-standard method to assess the presence of CSPH, which is defined as HVPG≥10 mmHg.

This is a prospective, multi-center trial conducted at 1 Guangzhou (Nanfang Hospital) and 2 Beijing (Beijing 302 Hospital, Beijing Shijitan Hospital) centers designed to determine the diagnostic performance of vHVPG (investigational technology) by anatomic CTA for non-invasive assessment of the CSPH in patients with compensated cirrhosis. Direct HVPG measurement by means of catheterization of a hepatic vein with a balloon catheter is the gold-standard method to assess the presence of CSPH, which is defined as HVPG≥10 mmHg.

Eligibility Criteria:
Inclusion Criteria:

* Age \>18 years
* Patients providing written informed consent
* Patients with compensated cirrhosis and scheduled to undergo clinically-indicated invasive HVPG measurement by means of catheterization of a hepatic vein with a balloon catheter
* Has undergone \> 64 multi-detector row CTA within 14 days prior to hepatic vein catheterization
* No hepatic-portal vein interventional therapy between the CTA and hepatic vein catheterization

Exclusion Criteria:

* Prior transjugular intrahepatic portosystem stent-shunt surgery
* Prior devascularization operation
* Has received a liver transplant
* Patients with known anaphylactic allergy to iodinated contrast
* Pregnancy or unknown pregnancy status
* Patient requires an emergent procedure
* Any active, serious, life-threatening disease
* Inability to adhere to study procedures
Corn Occupational Rhinitis SCIT Efficacy Study

Patients demonstrated allergic to corn pollen and timothy grass pollen (by allergy testing) who have undergone 1 to 2 years of subcutaneous allergen immunotherapy (SCIT) containing timothy grass extract with moderate symptomology (as documented via rhinitis symptom score surveys) will constitute the treatment group. Those who previously chose not to undergo SCIT who have documented symptomology and are skin test positive to corn pollen will constitute the control group. Prospective symptom score analyses and retrospective quality of life assessments (RQLQ) will be the primary and secondary efficacy outcome measures.

Statistical assessment suggests enrollment of 20 patients into the treatment group (defined above) and an additional 20 into the control group. Patients will be matched for the level of symptomology (based on symptom score surveys) and residing/working on corn-crop farms. The premise for this study is the cross-reactivity of putative immunogenic sites between timothy grass pollen and corn pollen. based on consensus genetic sequences. Thus, the hypothesis is the use of Timothy grass extract containing immunotherapy would diminish symptomology to corn-based occupational rhinitis. Enrolled patients will have signed IRB approved consent forms and have undergone SCIT for 1 to 2 plus years (treatment group) or not undergone SCIT therapy for the same time period (control group). Potential contribution to symptom scores from other sources (e.g. Ragweed) will be analyzed by assessment of local pollen counts.Efficacy assessment will compare prospective symptom score results and retrospective quality of life survey scores between the treatment and control group responses.

Eligibility Criteria:
Inclusion Criteria for treatment group:

1. Completing more than 1 year of timothy grass SCIT
2. Residing/working on/near a corn farm
3. Having an initial symptom score value of \> 8 (out of a possible 21).

Inclusion Criteria for control group:

1. Never treated with SCIT.
2. Residing/working on/near a corn farm
3. Having an initial symptom score value of \> 8 (out of a possible 21).

All accepted enrolled patients are healthy volunteers.

Exclusion Criteria:

1. Negative allergy test to corn pollen,
2. Not residing on/near farm growing corn,
3. An initial symptom score of \< 9.
e-Health Education Program at Workplace

The objective this study is evaluate if an e-Health education program at the workplace to contributes to improve quality of life from Office Workers. And:Life style modification; Improve physical activity Reduces on Anthropometric Measures; Reduces Pain and discomfort in the musculoskeletal system

Objective: The purpose of this study is evaluate the effectiveness of an e-Health education program at the workplace in the quality of life promotion.

Design: Double Blinded. Randomized clinical trial by cluster. Setting: Office Workers of the Universidade Publica do Estado da Bahia, Bahia State, Brazil. Participants: 348 office workers are enrollment, both sex, with over 18 year old.

Intervention: Participants will randomized in: (1) reference group will receive an e-learning health education compose by nine video-class according to the dimensions: 1) musculoskeletal health, 2) eating health e 3) mental health. A video will available by moodle platform every 20 days during six months. In this period the workers will monitored regarding to access the videos and and reinforcements to remain in the program. (2) intervention group: they will receive e-health education program with additional support healthcare tutor everyday.

Eligibility Criteria:
Inclusion Criteria:

* Technical-administrative workers, computer users for a minimum period of six months. ,
* Signed informed consent form

Exclusion Criteria:

* Suspected or confirmed pregnant workers at randomization time
* Mothers what Breastfeeding
* Workers in annual leave.
PatIent exPeRiences and prEFerence of trEatment foR Multiple Myeloma

This is a qualitative (interview) study to explore the experiences of people receiving treatment for MM and to understand what matters most to them when making treatment decisions.

People can receive many lines of treatment for multiple myeloma. We would like to understand more about the experiences of people being treated for multiple myeloma including what matters most to them when considering treatment options, how their experiences have differed with different treatments and if they have any treatment preferences. Patients at The Christie who have received five or more lines of treatment for Multiple Myeloma will be eligible to take part in this study. They will be asked to participate in an interview which should take approximately 30 minutes to an hour. During the interview they will be asked questions regarding their experiences and preference for treatment. Interviews will be conducted either in person or over the phone depending on patient preference. The interviews will be recorded by the research team using a Dictaphone and transcribed by an external transcription service called 1st Class Secretarial. The transcripts of all participant interviews will be reviewed by members of the research team and experiences will be identified and described.

Eligibility Criteria:
Inclusion Criteria:

1. Participants with confirmed MM (per standard disease specific diagnostic criteria)
2. Participants must have received ≥ 5 lines of treatment for MM and fit into one of the below treatment categories:

   1. Subset 1- Participants must have received an oral anti-cancer therapy and a bi-specific antibody treatment.
   2. Subset 2- Participants must have received an oral anti-cancer therapy and if they have not had a bi-specific antibody treatment, they must have received at least one IV therapy.
3. Aged 18 years of age or over
4. Able to provide informed consent
5. Able to communicate in English

Exclusion Criteria:

1. Aged under 18
2. Unable to understand and communicate in the English language
3. Unable to provide written informed consent
Bruxism Awareness in Dental Students

Clinical students in the Faculty of Dentistry were diagnosed with bruxism according to the bruxism assessment consensus 2018. A total of 128 students with (64) and without (64) bruxism, were asked 33 questions about their knowledge and self-awareness about bruxism.

This study included systemically healthy individuals aged 18 to 27. Intraoral and extraoral examinations were performed on 128 students with (64) and without bruxism (64), 4th and 5th-grade dental students at Bolu Abant İzzet Baysal University who met the inclusion criteria. The diagnosis of bruxism was based on the 2018 International Consensus and data collected through a validated 33-item questionnaire covering general information and bruxism awareness. The questionnaire included questions on bruxism's types, risk factors, symptoms, and impact on periodontal tissues, with multiple-choice responses. Statistical analyses were performed using IBM SPSS Statistics, and p\<0.05 was accepted as statistical significance

Eligibility Criteria:
Inclusion Criteria:

* Systemically healthy individuals

Exclusion Criteria:

* Individuals with mental retardation,
* Individuals with suicidal tendencies,
* Individuals with dementia,
* Individuals with psychosis
Effect of PEEP on Arterial Oxygen Partial Pressure in Elderly Patients With Lithotomy Position Using LMA Supreme™

The purpose of the present study is to compare the effect of PEEP on arterial oxygen partial pressure in elderly patients undergoing urologic surgery using LMA supreme™ in a lithotomy position.

Positive end-expiratory pressure (PEEP) during general anesthesia with mechanical ventilation is routinely used as a standard lung protective strategy to prevent postoperative pulmonary complications including atelectasis.

In urologic surgery, elderly patients are common. Since aging decreases the elasticity of lung tissues and allowing the collapse of small airways, old age is a risk factor for postoperative atelectasis. Lithotomy position is the preferred position in urologic surgery. However, it causes the abdominal viscera to displace the diaphragm cephalad, reducing lung compliance and resulting atelectasis. Therefore, in elderly patients undergoing urologic surgery with lithotomy position, PEEP may be essential to prevent postoperative atelectasis.

Laryngeal mask airway (LMA) has been widely used in urologic surgery with lithotomy position because of short surgical time and no necessity of administration of muscle relaxant. However, application of PEEP when using LMA is still controversy. Therefore, in the present study, we aimed to compare the effect of PEEP on arterial oxygen partial pressure in elderly patients undergoing urologic surgery using LMA supreme™ in a lithotomy position.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing urologic surgery with lithotomy position under general anesthesia
* Elderly patients (65 ≤ Age \< 80)
* American Society of Anesthesiologists (ASA) physical status: 1-3
* Patients who voluntarily agreed to participate in this clinical study

Exclusion Criteria:

* Heart failure (ejection fraction ≤ 40%)
* Hemodynamic instability during perioperative period
* Lung diseases (chronic obstructive pulmonary disease, asthma, bullae, pleural effusion)
* Obesity (BMI ≥ 30 kg/m2)
* Neck or upper respiratory tract pathologies
* An increased risk of pulmonary aspiration
* Anticipation of the difficult laryngeal mask fixation due to poor dentition
Manual Rotation in Persistent Occiput Posterior Position

Is part of routine obstetric care to attempt a manual rotation in all fetus that are in a persistent OP at delivery. Nevertheless, little is known about the success of this intervention or about the relation of some ultrasound measures with the outcome.

Persistent OP at delivery occurs in approximately 10% of fetuses and studies have shown an increase in short-term and long-term maternal and fetal complications such as prolonged labour, maternal exhaustion, fetal distress, instrumental delivery, caesarean delivery and severe perineal tears. Manual rotation of the fetal occiput to OA position has been described as a safe and effective intervention in the setting of labour arrest but evidence is limited. Therefore, the investigators aim to evaluate:

1. The success of manual rotation of the fetal occiput in OP in 2nd stage of labour; The relation of progression angle (PA) accessed by ultrasound and the success of manual rotation; This is as prospective study with a sample size calculated of 50 participants.

1. º Identify an OP position during digital examination in the first evaluation at full cervical dilatation (t=0)
2. º Get informed consent from the pregnant woman.
3. º Wait for the first urge to push or T=30 m (multiparous) or T=60 (nulliparous)
4. º Confirm fetal head position by ultrasound and measure PA.
5. º Attempt a manual rotation to anterior position accordingly to the protocol.
6. º Confirm fetal head position by ultrasound.

Eligibility Criteria:
Inclusion Criteria:

* Singleton pregnancies
* \>37 weeks of pregnancy
* Fetus in cephalic presentation
* Fetal weight estimation P10-90
* Fetal head in a posterior position in the moment of full cervical dilatation.

Exclusion Criteria:

- do not give or do not be able to give written consent
Effect of Exergame-Based Exercise on Hamstring and Quadriceps Isokinetic Muscle Parameters

The aim of this study is to investigate the effects of two different exercise methods (video-based game exercise group and real (non-game) exercise group) to increase knee strength in healthy individuals on muscle strength, balance and lower extremity functional parameters. In our study, it will be revealed which technique will have what effect in the strengthening, which will be done by taking certain criteria into consideration. Participants will be randomized into three different groups. Two groups, except the control group, will exercise three times a week for 6 weeks. All participants will be assessment twice in total, at the beginning of the study and 6 weeks later. It is thought that the results obtained here will contribute to the literature.

The study was planned to include individuals studying at Halic University, who met the inclusion criteria and volunteered to participate in the study. Evaluated participants will be randomly assigned to three different groups (control group, video-based game exercise group, real game-free exercise group). The sealed envelope method will be used in randomization. All evaluations by the same physiotherapist will be performed twice, before exercise and after 6 weeks of exercise. Both exercise groups will practice under the supervision of a physiotherapist. The control group will not exercise and will only be evaluated twice. At the end of the study, those in the control group will be able to participate in any exercise group they want for 6 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Being a woman between the ages of 18-25
* Being a 1st or 2nd year physiotherapy and rehabilitation student or a student in any department other than sports sciences
* Being sedentary or underweight according to fit score
* Being at normal values according to body mass index
* Full knee flexion-extension joint range of motion
* Volunteering to participate in the study

Exclusion Criteria:

* Knee pain, history of injury in the last 6 months,
* Doing regular physical activity in the last 6 months,
* Neurological, cardiorespiratory, musculoskeletal, endocrine, renal, metabolic and other related disease(s) that will prevent the performance of exercises
* History of lower extremity orthopedic surgery
* Chronic use of medications or anti-inflammatory drugs
Anti-Mullerian Hormone (AMH) is a Marker for Ovarian Reserve. There Are Many Studies About AMH Changes in Ovarian Surgery, But Little is Known for Other Surgeries. We Seek to Investigate the Hormone Variations Before and After Uterine Artey Ligation for Postpartum Hemorrage (PPH)

Anti-Mullerian hormone (AMH) is a marker for ovarian reserve. There are many studies about AMH changes in ovarian surgery, but little is known for other surgeries. We seek to investigate the hormone variations before and after uterine artey ligation for postpartum hemorrage (PPH)

All patients belong to the same group. The blood samples will be collected at the time of surgery and 3 months after surgery from the patients who need uterine artery ligation for PPH. The blood samples will be centrifuged within 2 hours after being obtained and assessed on the same day. AMH concentrations will be measured with an enzymatically amplified two-sided immunoassay

Eligibility Criteria:
Inclusion Criteria:

* age 18- 40 years
* no systemic or endocrine diseases
* patients who had uterine artery ligation due to PPH

Exclusion Criteria:

* Pregnancy with IVF or oosit donation
* Patients with endocrinopathy, diseases which require radiotherapy and chemotherapy etc.
* Patients with BMI \>40