cyrilzakka/clinical-trials huggingface dataset:
Predicting Factors for the Outcome of Surgical Treatment for Patellar Instability

The purpose of the study is:

1. to analyze the success of operative stabilization of the patellar joint with the reconstruction of the medial patellofemoral ligament (MPFL) in terms of the subjective status of the knee, the general quality of life, and physical activity
2. to study the influence of specific preoperative (demographic and anamnestic data of the patient, radiological parameters of the knee joint) and intra-operative factors (place of femoral insertion of MPFL graft, patella height, degree of damage to the cartilaginous surfaces of the knee joint) on the subjective outcome of surgical treatment.


Eligibility Criteria:
Inclusion Criteria:

* patients over 18 years of age
* surgical intervention with MPFL reconstruction
* with or without tibial tuberosity transposition (TTT).

Exclusion Criteria:

* trochleoplasty,
* corrective knee osteotomy
* reparative cartilage treatment
* reconstruction of other knee ligaments
* meniscus repair
* movement impairments
* plegia
* paresis
* neuromuscular diseases
* participation rejection
* rejection to complete the control questionnaires
* lack of understanding of the Slovenian language
Study In Patients With Kidney Cancer Treated With Sutent

Objective of this study is to increase knowledge about safety, tolerability, quality of life and efficacy under conditions of routine use of sunitinib.

Consecutive patients with advanced or metastatic renal cell carcinoma, that are indicated for 1st or 2nd line anticancer therapy

Eligibility Criteria:
Inclusion Criteria:

* Consecutive patients with advanced or metastatic renal cell carcinoma, that are indicated for 1st or 2nd line anticancer therapy

Exclusion Criteria:

* Hypersensitivity to sunitinib malate or to any of the excipients
* Any other contraindication to the use of sunitinib malate (based on decision of the treating physician).
Effects of Masticatory Muscles Training Exercises on the Masticatory Performance and Rehabilitation of Stroke Patients

Stroke is one of the top causes of death and morbidity of adults, especially the older population in the economically developed countries. People who survives from stroke attack usually suffer from a wide range of impairments and often have poor chewing ability even when they are physically well enough to be discharged from hospital. Aim of this proposed study is to investigate the effects of providing masticatory muscles training exercises on the masticatory performance, nutrition intake and general health conditions of stroke rehabilitation patients. Around 100 stroke patients undergoing rehabilitation in the rehabilitation centre in Tung Wah Eastern Hospital, Hong Kong, will be recruited and allocated randomly into one of two study groups: Group 1 will be provided with an oral device for chewing muscles exercises and training exercises on chewing (the intervention group); and Group 2 will just follow the current stroke rehabilitation programme which does not have any training in chewing (a negative control group). A video on the chewing muscles exercises will be produced and placed online for the participants in Group 1 to view on demand. Data from the participants in both groups will be collected at four time points: at baseline before provision of the interventions, and at around 1, 3 and 6 months after the intervention. Each participant will be interviewed by a trained interviewer and undergo a clinical examination. The information collected will include the participant's oral health status such as numbers of decayed teeth and occluding tooth pairs, and their masticatory performance measured both objectively by chewing on a colour-changeable gum and subjectively by a chewing function questionnaire. Their type of stroke (ischemic or hemorrhagic) and general health conditions such as physical function status and nutrition intake will be recorded. The masticatory performance and general health conditions of the two groups of study participants at baseline and follow-up evaluations will be compared to assess if the masticatory muscles training exercises can improve the rehabilitation outcomes. It is anticipated that this proposed randomized trial will provide high-level clinical evidence to support the introduction of masticatory muscles training exercises into the rehabilitation programme of stroke patients and to inform how the exercises will benefit the patients, such as improving their chewing ability and general health conditions.


Eligibility Criteria:
Inclusion Criteria:

* aged 30 years or above, first-time stroke patient within 20 days post-stroke and medical status being stable

Exclusion Criteria:

* unable to follow basic instructions, unable to communicate clearly, being bed-ridden, dysphagic (on nasogastric tube) and not having any natural teeth in either of the jaws
Docetaxel + Prednisone With or Without Radiation for Castrate Resistant Prostate Cancer

The main purpose of this study is to find out whether adding radiation therapy to the standard treatment of chemotherapy for prostate cancer is tolerated well and is more effective than the standard treatment of chemotherapy alone

Most physicians would consider chemotherapy to be the standard for prostate cancer. In this study all participants will receive the standard chemotherapy. In addition, half the participants will also receive radiation therapy. It is hoped that the radiation therapy will provide additional benefit. The use of radiation therapy and chemotherapy for patients with this kind of cancer is not considered standard treatment at the present time.

Participants will be randomized into groups (or Arms) by a computer program. Participants randomized to Arm 1 will receive chemotherapy alone. Participants in Arm 2 will receive chemotherapy and radiation therapy. Participants in both groups (Arm 1 and Arm 2) will receive standard chemotherapy with docetaxel and prednisone. Docetaxel is given through a needle in a vein in the arm every 3 weeks or 21 days. Participants will take a prednisone tablet once per day until 21 days after the last dose of docetaxel. In addition, all participants will be given a drug called dexamethasone twice daily for 6 doses to help with the side effects of docetaxel. Participants in Arm 2 will first receive radiation therapy to the pelvis and prostate gland. Radiation therapy will be delivered once a day, five days a week for a total of 8-9 weeks. Then beginning 4-6 weeks after the end of radiation therapy, chemotherapy will be given, as described above. In both Arms, the total number of cycles of docetaxel and prednisone will depend upon how the tumor responds to these drugs. All patients should receive a minimum of three cycles of chemotherapy.

Eligibility Criteria:
Inclusion Criteria:

* Participants must have a diagnosis of castrate resistant prostate cancer.
* Participants must be 18 years old or older.
* Biopsy of tissue from the prostate or enlarged lymph nodes may be required.
* Patients must sign study specific informed consent prior to study entry.
* Men of child-producing potential must be willing to consent to use effective contraception while on treatment and for at least 3 months afterwards.

Exclusion Criteria:

* Participants cannot have prior chemotherapy for prostate cancer.
* Participants cannot have prior radiation therapy to the pelvis.
Mehri Turki Surgical Technique of the Webbed Neck

The webbed neck is one of the conspicuous deformities of Turner syndrome that presents a surgical challenge. Despite the availability of surgical techniques, surgical outcomes are not always acceptable and recurrence occurs. Mehri Turki performed a surgical technique based on a latéral cervical approach allowing direct visual control to manage the fibrotic band. It provides a high level of visual control so that vulnerable anatomic structures are easily protected.

Five girls between 17 and 19 years old, with Turner syndrome, had a webbed neck (pterygium colli) with low and laterally displaced nuchal hairline. The surgical technique aims to correct neck contour and hairline placement while concealing cervical scars. Thus, Preoperative drawing delimitated the harmful triangular hairy skin next to the fibrous band extending from the mastoid to the acromion. Besides, the predefined design drawings provide the exact placement of the future hairline. Choosing a prone position for bilateral and symmetrical repair, the surgical technique was as follows:

The incision was made at the junction of the hairless skin and the hairy skin from the mastoid up to the lower end of the webbing skin, in front of the acromion and completed by Z plasty to avoid scar contracture. The subcutaneous skin was undermined in the anterolateral direction, exposing the fibrous fascial band which must be excised to prevent recurrence. the harmful skin having a triangular shape was excised considering the future hairline. Skin closure was done after the superior traction of the posterior cervical advancement.

Eligibility Criteria:
Inclusion Criteria:

* webbed neck with abnormal hairline

Exclusion Criteria:

* Surgical contraindication for any health concern
* Puberty age
Optimization of Fetal Biometry With 3D Ultrasound and Image Recognition

In the proposed clinical investigation, the investigational device (BabySize3D) will provide automated plane extraction and automated biometry measurements from 3D US volumes. The results obtained from the investigational software


Eligibility Criteria:
Inclusion Criteria:

* evolutive pregnancy with one fetus with a Gestational Age between 16 and 30 weeks
* aged between 18 and 65 years.
* social welfare benefit recipient
* willing and able to provide informed consent

Exclusion Criteria:

* under 18 years old
* multiple pregnancy
* over 18 years old and mentioned in French law articles L.1126-6 et L-1126-8,
* fetal malformation or suspected fetal malformation
* technical conditions that do not allow for standard fetal biometry (abdominal wall, fetal position, BMI \> 25 kg/m2)
* fetal biometry non indicated in the standard pregnancy follow-up
* unwilling or unable to provide informed consent (e. g. physical, mental disability or linguistic factor that compromises patient information)
Evaluation of Fibrin Sealant 2 in Vascular Surgical Procedures

A comparison of a fibrin sealant versus manual compression in stopping surgical bleeding during vascular procedures.


Eligibility Criteria:
Inclusion Criteria:

* Male and female subjects, 18 years or older, requiring elective, primary or repeat vascular procedures with at least one end-to-side femoral or upper extremity vascular access arterial anastomosis (e.g. femoral-femoral, femoral-popliteal, femoral-tibial, ilio-femoral, aorto-bifemoral, abdominal aortic aneurysm, upper extremity vascular access for dialysis) using uncoated or heparin-coated PTFE grafts and polypropylene sutures (size 5-0 or 6-0) with a 1:1 needle-to-thread ratio.
* Following initial arterial clamp release, the study surgeon determines that adjunctive measures are needed to obtain haemostasis at the SAS.
* Subjects must be willing to and capable of participating in the study, and provided written informed consent.

Exclusion Criteria:

* Subjects undergoing re-vascularisation using autologous conduits (e.g. saphenous vein) or prosthetic material other than uncoated or heparin-coated PTFE.
* Subjects undergoing emergency surgery.
* Subjects with any intra-operative findings that may preclude conduct of the study procedure.
* Subjects with known intolerance to heparin, blood products or to one of the components of the study product.
* Subjects unwilling to receive blood products.
* Subjects with autoimmune immunodeficiency diseases (including known HIV).
* Subjects who are known, current alcohol and / or drug abusers.
* Subjects who have participated in another investigational drug or device research study within 30 days of enrolment.
* Female subjects who are pregnant or nursing.
Knowledge, Attitude, And Practice In A Group Of Egyptian Dentists Towards Preventive Measures In Pediatric Dentistry: A Cross-Sectional Study

The study will include general dental practitioners or dental specialists from Police Academy Hospital and pediatric dentists from Pediatric dentistry department at Faculty of Dentistry Cairo University.

A self-administered questionnaire will be given to dentists by direct interviewing and they will be allowed to complete the questionnaire in Faculty of Dentistry, Cairo University or Police Academy Hospital. The data will be based on a collection of responses to the 38 items in the questionnaire.


Eligibility Criteria:
Inclusion Criteria:

* Egyptian dentists working in either Faculty of Dentistry Cairo University or Police Academy Hospital.
* Postgraduate students.

Exclusion Criteria:

* Refusal to participate in the study
Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Lung Transplant

This is a proof of concept, single center study for the donation of HCV-positive lungs to HCV negative recipient patients, with preemptive, interventional treatment with 8 weeks of commercially available DAA therapy to prevent HCV transmission upon transplantation.

The goal of this study is to determine if preoperative dosing and sustained administration of pan-genotypic DAA therapy after lungs transplantation prevents the transmission of hepatitis C virus (HCV) infection from an HCVpositive donor lung to an HCV naïve recipient.

Eligibility Criteria:
Inclusion Criteria:

* Met MGH transplant center criteria, listed for lung transplant
* Able to sign informed consent

Exclusion Criteria:

* Pregnant or nursing (lactating) women
* HIV positivity
* Any contra-indication to lung transplantation per center protocol
* For study patients in whom Epclusa® therapy is being considered, exclusion criteria includes patients on the following p-glycoprotein inducers or moderate to potent CYP inducers that cannot stop therapy: carbamazepine, phenytoin, phenobarbital, oxcarbazepine, rifabutin, rifampin, rifapentine, St. John's wort.
* For study patients in whom MavyretTM therapy is being considered, exclusion criteria includes patients on the following medications who cannot stop therapy: carbamazepine, rifampin, St. John's wort, and ethinyl estradiol-containing oral contraceptives.
Importance of Exercise Educational Materials in Chest Physiotherapy

The patients who have undergone thoracotomy operation will include in the study. All patients have chest physiotherapy in the intensive care unit. Patients will be randomized and divided into two groups. One group will be given an exercise form with details and photographs of the exercises. No documents will be given to the other group. The program includes breathing exercises, incentive spirometry study, coughing and graded ambulation. After 1 intensive care session, patients are admitted to the service rooms due to routine procedures. The patients will be served in the afternoon and will be questioned whether they are performing their exercises or not.

* Physiotherapy will be applied to patients undergoing thoracotomy after 24 hours of intensive care hospitalization.
* Patients will be randomized and divided into two groups. Study group will be given exercise form. Control group not.
* Physiotherapy program includes breathing exercises, incentive spirometry study, graded ambulation and both groups will receive this physiotherapy session in the intensive care unit..
* After the patients are admitted to the service rooms, a service visit will be performed, the amount of remembering of the exercises and whether the exercises are performed in a proper form will be questioned.

Eligibility Criteria:
Inclusion Criteria:

* Between 18-70 years
* Having undergone post-thoracotomy
* Hemodynamically stable,
* To be conscious

Exclusion Criteria:

* Excessive pain
* Neurological complications
* Cardiovascular and musculoskeletal problems that prevent him from exercising
* Not wanting to be involved in the study
* Fever above 38 degrees
To Analyze the Kinematic Change of Lower Limb During Jumping Task With Wearable Device - 2-year Program

This study will be conducted in two years: In the first year, the investigators would verify the relation between wearable device and motion analysis and its validity and reliability. In advance, the investigators are going to observe the effect of dynamic taping in lower limb biomechanics of high-school soccer and basketball athletes. In the second year, the investigators would recruit high school soccer and basketball athletes to examine the effect of dynamic taping in lower limb biomechanics under fatigue.

In Taiwan, it was estimated that at least 1,000 cases of patients require anterior cruciate ligament (ACL) reconstruction annually. Despite the improving of surgical technique, there are only 65% patients who received the ACL reconstruction return to their pre-injury level of sport. Therefore, to prevent ACL injuries in athletes is critical. The mechanism of ACL injury is greatly associated with lower limb biomechanics.

Motional analysis is the golden standard for biomechanics. However, with the advancement in technology, the investigators could explore lower limb biomechanics conveniently by wearable device. But the validity and reliability need further confirmation.

According to previous studies, the investigators could predict the possibility of ACL injuries by the change of biomechanics, such as hip adduction, internal rotation and knee valgus. Dynamic taping is a newly developing technique with better elasticity and extensibility. Studies showed that dynamic taping improve the biomechanics of knee joint. Hence, the investigators can adjust the faulty movement as soon as possible to prevent the occurrence of ACL injuries.

This study will be conducted in two years: In the first year, the investigators would verify the relation between wearable device and motion analysis and its validity and reliability. In advance, the investigators are going to observe the effect of dynamic taping in lower limb biomechanics of high-school soccer and basketball athletes. In the second year, the investigators would recruit high school soccer and basketball athletes to examine the effect of dynamic taping in lower limb biomechanics under fatigue.

Eligibility Criteria:
Inclusion Criteria:

* 1st Year: 16+ health volunteers
* 2nd Year: senior high school and college athlete

Exclusion Criteria:

* Those who are unable to exercise due to acute joint, muscle or nerve injury in the lower extremities
* Lower extremity surgery within 1 year
* Head trauma within 6 months
* Those with vestibular injury within 6 months
* Allergic to Dynamic tape
* Pregnant
* Visual coordination impairment
Optimization of Treatment and Management of Schizophrenia in Europe (OPTIMISE): Substudy Site Copenhagen

The investigators want to relate disturbances in first-episode schizophrenic patients in (dopaminergic) D2 receptors, brain structure, brain function, and information processing to each other and to psychopathology. Additionally, the investigators want to examine the influence of D2 receptor blockade on these disturbances. The investigators expect disturbances in the dopaminergic system at baseline to correlate with specific structural and functional changes and with disruption in information processing as measured with psychophysiological and neurocognitive methods - and investigators expect D2 receptor blockade to reverse some of the functional and cognitive impairments. The investigators do not expect any effect of treatment on brain structure.

The study is designed as a 4 week case-control follow-up study of 90 FE pt. with SCZ and 90 controls matched with regard to age, gender, and parental socio-economic status. All subjects will be examined with a diagnostic interview (SCAN, Schedule for Clinical Assessment in Neuropsychiatry), medical and family history, and physical examination before inclusion. At baseline subjects will be examined with single photon emission computed tomography (SPECT), MRI, fMRI, psychophysiology, neurocognition. In addition, they will be screened for drugs, genetic testing, and ECG. Patients will further be examined with clinical validated rating scales to measure psychopathology, subjective well-being, and side-effects. After a period of 4 weeks all assessments are repeated. During that period patients will be treated with amisulpride, while healthy controls will receive no treatment at all. Efficacy of antipsychotic treatment will be evaluated after this initial period of 4 weeks. All subjects will be re-assessed in the same test battery as mentioned above, except for SPECT and fMRI, after a period of 6, 12, and 24 months.

Eligibility Criteria:
Inclusion Criteria:

* Schizophrenia, schizophreniform or schizoaffective disorder (DSM-IV)
* Age 18-40 years
* Written informed consent.

Exclusion Criteria:

* A time interval between the onset of positive symptoms (hallucinations and/or delusions) and study entry exceeding two years.
* Prior use of antipsychotic medication longer than an episode of two weeks in the previous year and/or 6 weeks lifetime.
* Intolerance to one of the drugs in this study. Patients who are coercively treated at a psychiatric ward (based on a judicial ruling)
* Patients who are represented by a legal ward or under legal custody
* The presence of one or more of the contraindications against any of the study drugs as mentioned in the SPC texts
* Pregnancy, as determined through a pregnancy test, or lactation
Psychophysiological Correlates of Mindfulness Based Cognitive Therapy (MBCT) in Recurrent Depression

The study investigates cognitive attention, rumination and psychophysiological (EEG) processes in healthy subjects and remitted patients with at least three previous depressive episodes. The investigators expect that Mindfulness Based Cognitive Therapy prevents future depressive episodes and has influence on cognitive and psychophysiological measures.


Eligibility Criteria:
Inclusion Criteria:

* recurrent depression with at least 3 previous MD-episodes, currently remitted (no symptoms)

Exclusion Criteria:

* current depression
* lifetime schizophrenia
* bipolar or schizoaffective disorder
* any neurological disorders
* other psychopathology during last 3 years