cyrilzakka/clinical-trials huggingface dataset:
The Effect of Spinal Mobilization on Respiratory Parameters in Parkinson's Disease Patients

Parkinson's patients suffer from respiratory distress for different reasons. It is thought that physiotherapy methods that have an indirect effect on the diaphragm can improve respiratory functions. The aim of this study is to investigate the effects of spinal mobilization and diaphragmatic breathing techniques on respiratory function.

Respiratory complications are one of the most common causes of death in Parkinson's patients. Camptocormia may develop in Parkinson's disease and other pathological conditions involving the basal ganglia, which can be defined as an abnormal flexion of the thoracolumbar spine of 45° or more, which increases during walking or standing and disappears completely in the supine position. Parkinson's patients with camptocormia often complain of dyspnea, which can be attributed to reduced lung capacity due to limited chest expansion.

Restrictive changes due to respiratory muscle dysfunction in Parkinson's disease, upper airway obstruction, abnormal ventilatory control, and drug use such as levodopa have an effect on respiratory functions.

Restrictive dysfunction has been reported in 28-94% of patients with Parkinson's.

Postural disorders such as camptocormia can also lead to restriction. One study found that the lung volumes of Parkinson's disease patients with camptocormia decreased, although it was not associated with major clinical changes.

Diaphragmatic dyskinesia in Parkinson's patients may also lead to a restrictive deterioration in respiratory functions.

Studies examining the effects of chest and diaphragm mobilization on spirometric parameters in patients with cerebral palsy reported that the applied mobilization and soft tissue techniques improved FEV1 and FVC. The effect of indirect diaphragmatic treatments with vertebral mobilization in individuals with Parkinson's who are at risk of experiencing restrictive respiratory problems is unknown. The aim of this study is to examine the effects of spinal mobilization techniques for the diaphragm on respiratory function parameters and posture.

Eligibility Criteria:
Inclusion Criteria:

* Have been diagnosed with Parkinson's disease
* Volunteering to participate in the study
* Modified Medical Research Council (MMRC) score \>2

Exclusion Criteria:

* Those with COVID-19
* Diseases that increase intra-abdominal pressure
* Diseases affecting diaphragmatic motility
* Those who had a recent thoracic or abdominal operation
* Those who have a parenchymal, pleural or chest wall mass that will cause restriction on a recent chest X-ray or CT will not be included in the study
Impact of Anaesthesia Mode on Evaluation of LEEP Specimen Dimensions

To study the influence of anaesthesia (local by cervical block vs. general or spinal anaesthesia) on height and volume of resection specimens in case of conization treatment for cervical intraepithelial neoplasia (CIN).

Prospective observational study of all patients who underwent a first treatment by loop electrosurgical excision procedure (LEEP) for CIN. Height of fresh resection specimens was first measured by the operator and then by the pathologist after formaldehyde fixation. Volume of fresh specimens was measured in a measuring cylinder by fluid displacement.

Measure of conization specimens can be done in the operating theatre on fresh specimen or by pathologist after fixation. Methods and conditions of specimen measurement are rarely, if ever, described in published studies.

To study the influence of anaesthesia (local by cervical block vs. general or spinal anaesthesia) on height and volume of resection specimens in case of conization treatment for cervical intraepithelial neoplasia (CIN).

Prospective observational study of all patients who underwent a first treatment by loop electrosurgical excision procedure (LEEP) for CIN. Height of fresh resection specimens was first measured by the operator and then by the pathologist after formaldehyde fixation. Volume of fresh specimens was measured in a measuring cylinder by fluid displacement.

Eligibility Criteria:
Inclusion Criteria:

* every patient who underwent a first conization procedure
* regardless of indication

Exclusion Criteria:

* patient's refusal to participate.
Does Body Composition Predict Running Time?

Several studies performed in elite endurance athletes have shown that running performance may be determined by a low fat mass in the overall population.

The "Course de l'Escalade" occurs yearly during the first week-end of December. This race takes place in the city of Geneva. The distance of this race is 7.3 km for all men and elite women, and 4.8 km for non-elite women. During this race, measurement of body composition by biolelectrical impedance analyses (BIA) were performed in volunteer, between December 1999 and 2017.

Hypothesis :

We hypothesize that:

1. A low fat mass is associated with a slower running time, when adjusting for age, body weight, and habitual physical exercise.
2. An increase in fat mass over time increases running time over the years

Objectives :

1. To evaluate whether total and regional body composition is associated with running time at the "Course de l'Escalade".
2. To determine whether changes in body composition with progressive aging lead to changes in running time.


Eligibility Criteria:
Inclusion Criteria:

* All subjects who underwent a measurement of body composition by tetrapolar bioelectrical impedance analyses (BIA) at the "Course de l'Escalade", a fun race occurring yearly in Geneva, between December 1999 and 2017.

Exclusion Criteria:

* Measurements of people \<18 years at the time of BIA measurement.
* Measurements of people who did not perform or finish the race.
Droplet Digital PCR Combines With Transcriptome Analysis in Early Warning of Sepsis in the Emergency Department

Rapid identification of pathogens and early warning of host response are key to improve the prognosis of sepsis. Establishing a comprehensive identification system based on pathogen identification and host immune status is an effective way to achieve early warning stratification of patients with infections in the emergency department. This prospective multicenter clinical study will combine droplet digital PCR (ddPCR) and transcriptomic molecular target assay for validation in patients with suspected sepsis in the emergency department. The purpose is to (1) compare the efficacy of ddPCR with blood culture for early diagnosis and prognosis; (2) assess the diagnostic value of transcriptomic molecular targets based on 29 messenger RNA for the presence or absence of infection as well as infectious agents, and to evaluate their efficacy for prognosis; and (3) assess the diagnostic and therapeutic monitoring value of ddPCR combined with transcriptome analysis methods.

Rapid identification of pathogens and early warning of host response are key to improve the prognosis of sepsis. Establishing a comprehensive identification system based on pathogen identification and host immune status is an effective way to achieve early warning stratification of patients with infections in the emergency department. Therefore, based on our preliminary single-center study, this prospective multicenter clinical study will combine droplet digital PCR (ddPCR) and transcriptomic molecular target assay for validation in patients with suspected sepsis in the emergency department. The purpose is to (1) compare the efficacy of ddPCR with blood culture for early diagnosis and prognosis; (2) assess the diagnostic value of transcriptomic molecular targets based on 29 messenger RNA for the presence or absence of infection as well as infectious agents, and to evaluate their efficacy for prognosis; and (3) assess the diagnostic and therapeutic monitoring value of ddPCR combined with transcriptome analysis methods. In a word, this study will be undertaken to assess the diagnostic and therapeutic monitoring value of early warning models for sepsis in emergency department and to promote them to improve the identification ability of emergency infections.

Eligibility Criteria:
Inclusion Criteria:

* age ≥ 18 years, regardless of sex
* MSS≥2 score
* written informed consent obtained

Exclusion Criteria:

* Age \< 18 years, regardless of sex
* Patient's ICU length of stay \<24 hours
* Malignant tumor, HIV patients or any terminal-stage disease
* Known pregnancy or lactation
* Participation in other clinical trials
* Inadequate clinical information or missing experimental data
* No signed informed consent obtained
Performances of a Brief Assessment Tool for the Early Diagnosis of Geriatric Syndromes by Primary Care Physicians

The AGE (Active Geriatric Evaluation) aims to develop a brief assessment tool adapted to the primary care setting.

The AGE (Active Geriatric Evaluation) program is a collaborative project between a primary care institution and a specialised geriatric unit that aims to develop a brief assessment tool (BAT) adapted to the primary care setting. The objective of this study is to assess the performances of the BAT to identify major geriatric syndromes: cognitive impairment; mood disorder; functional impairment; urinary incontinence; malnutrition; gait and balance impairment; osteoporosis; hearing impairment; visual impairment.

In order to achieve our objective, we plan to recruit 155 patients \> 70 years old in primary care settings for which primary care physicians will perform the BAT (composed of specific questions and clinical exams). At the end of the consultation, the primary care physician will fill a questionnaire where the absence/presence of syndromes will be recorded (according to the findings of the BAT). Each patient will be then seen a second time by expert geriatricians that will perform a full geriatric evaluation (90 minutes). This will allow to calculate the performances of the intervention (BAT) in terms of sensibility /specificity,...

Eligibility Criteria:
Inclusion Criteria:

* Age \> 70 years
* follow-up by general practitioner
* good understanding of french or presence of a translater
* No previous or on-going geriatric consultation
* Patient able to provide consent or a relative is present that can provide a consent instead

Exclusion Criteria:

* Age \< 70 years
* No follow-up by general practitioner
* Unable to understand French or absence of a translater
* On-going geriatric follow-up
* Patient unable to provide consent or a relative is absent
Nutrition of Premature Infants With Human Breastmilk Fortifier

The objective of the study is to compare two human milk fortifiers with different protein content and LCPUFA in a group of very low birth weight infants.

This study is a multi-center, third party-blinded, randomized, controlled, parallel- group, prospective trial comparing growth with a liquid human milk fortifier with higher protein content and LCPUFA and a control powdered human milk fortifier added to breast milk and fed to premature infants. The trial will be conducted in 11 centers in Chile. The enrollment period is expected to be approximately 18 months. To allow for dropouts, approximately 160 participants will be randomized.

Eligibility Criteria:
Inclusion Criteria:

* Premature infant equal or under 31 weeks gestational age at birth
* Birth weight equal or under 1,250 g
* Predominantly fed breast milk (mother's milk or donor milk) on study day 0
* Appropriate birth weight for gestational age (AGA) - defined as birth weight between and inclusive of the 10th and 90th percentiles on the Fenton growth chart
* Singleton or twin birth (both twins do not need to qualify and be randomized into study)
* Birth weight is ≤1,000 g and participant is ≤ 40 days of age on study day 0
* Birth weight is above 1,000 g and participant is ≤ 30 days of age on study day 0
* Enteral intake of 80 mL/kg/d of unfortified breast milk on study day 0
* Anticipate mother's willingness to breast milk for at least 28 days from study day 0
* Signed informed consent obtained

Exclusion Criteria:

* History of underlying metabolic or chronic disease, congenital malformation, or any other condition which, in the opinion of the Investigator, is likely to interfere with: the ability of the participant to ingest food, normal growth and development of the participant, or the evaluation of the participant
* 5 minute APGAR score ≤ 4
* Major surgery that required general anesthesia prior to first day study (note: persistent ductus arterious ligation is allowed)
* Received pharmacologic doses of glucocorticoids during 3 consecutive days (72 hours) prior to or on day one of study (physiologic hydrocortisone administration up to 1.5 mg/kg/d is permitted)
* Ventilator-dependent and requiring ≥ 40% fraction of inspired oxygen (FiO2) on day one of study (ventilator dependent and requiring ≤ 40% FiO2 and/or nasal canula, and/or nasal continous positive airway pressure (CPAP) and/or oxygen hood is allowed)
* Grade III or IV bilateral intraventricular hemorrhage (IVH) prior to or on study day one
* Feeding intolerance to breast milk feedings on study day one
* Consumption of more than 3 feedings or 12 hours of continuous feeds of fortified breast milk prior to study day one
* Fluid restriction \< 120 mL/kg/d
* History of creatinine \>2.0 mg/dL 7 days prior to or on study day one
* Currently receiving or plan use of probiotics
Influence of Emotion in a Test Run Forgetfulness

Currently there is uncertainty on how schizophrenic patients feel pain. Pain has several components including cognitive behavior which allow humans to perceive it as a negative emotion. It is difficult to say precisely what are the differences in cognitive processing between the emotional component of pain and painless another negative emotion (eg fear). However, pain and negative emotion have some neural networks together and there are many common ways between emotional processing (pain or negative) and storing information (limbic system).

The study is to go 1 time in hospital for memory test. These tests consist in:

* Group 1: words to painful sense will be shown on a screen, one at a time for 5 seconds. Patient or healthy volunteer will need to retain them. Then these same words, mixed with others that patient/healthy volunteer will not learn, will again be displayed on the computer screen one at a time for 5 seconds. Upon the occurrence of a word, patient/healthy volunteer must press the 'L' key if they think they have learned the word or the "D" key on the keyboard if they feel that they have not learned this word.
* Group 2: words to negative sense will be shown on a screen, one at a time for 5 seconds. Patient or healthy volunteer need to retain them. Then these same words, mixed with others that patient/healthy volunteer will not learn, will again be displayed on the computer screen one at a time for 5 seconds. Upon the occurrence of a word, patient/healthy volunteer must press the 'L' key if they think they have learned the word or the "D" key on the keyboard if they feel that they have not learned this word.

  15 schizophrenic will be included in group 1 and 15 other schizophrenics in group 2.

  15 Healthy volunteer will be included in group 1 and 15 other Healthy volunteer in group 2.

Eligibility Criteria:
Inclusion Criteria:

* Patients:
* schizophrenic age 18 years to 55 years
* Stabilized, clinical and therapeutic point of view, since at least one month.
* Good knowledge of French
* Healthy volunteer
* age 18 years to 55 years
* Good knowledge of French
* Matching on age (± 5 years) and level of study patients

Exclusion Criteria:

* Patients
* History of head trauma, neurological disease with cerebral repercussion or not stabilized or serious physical illness causing pain\> 3 months.
* Recent Amendment of psychotropic therapy (\<1 month)
* Consumption of benzodiazepines long-term (negative effect on memory capacity)
* Troubles Related to the use of a psychoactive substance, as defined by the DSM IV (recent use, abuse, dependence or withdrawal).
* Healthy volunteer
* Consumption of benzodiazepines long-term (negative effect on memory capacity)
* Troubles Related to the use of a psychoactive substance, as defined by the DSM IV (recent use, abuse, dependence or withdrawal).
Comparison of Three Tourniquet Application Methods in Primary Total Knee Arthroplasty Surgery

Different strategies of tourniquet application during elective primary total knee arthroplasty are thought to be associated with different outcomes. In that context, the study investigates different tactics in the search of optimal application of the tourniquet and the related fluid management during 24 perioperative hours.

The optimal application of tourniquet should reduce perioperative blood loss, create bloodless operative field, improve cementing technique and shorten surgery time. Meanwhile, inadequate application may increase the risk of deep vein thrombosis and pulmonary thromboembolism. Previous attempts to compare the tourniquet strategies in respect to the perioperative blood loss did not show significant difference. The investigators use the volume loading test aiming to optimize the fluid status and obtain the hemoglobin concentration in the conditions of standardized plasma dilution. The test is deployed just before the surgery and after postoperative 24 hrs in ICU. Functional outcomes and possible length of hospital stay is also evaluated.

Eligibility Criteria:
Inclusion Criteria:

* Patients with osteoarthritis of the knee undergoing total knee arthroplasty with spinal-epidural anesthesia
* Age \> 50 and \< 80 years
* ASA (American Society of Anesthesiology Classification) II physical status
* Signed informed consent form

Exclusion Criteria:

* History of a bleeding disorder
* Current chronic anticoagulation therapy
* History of DVT (Deep Vein Thrombosis), thromboembolic complications, acute cardiac insufficiency
* Anemia before surgery required blood transfusion
* ASA I, ASA\>=III physical status
* Age \< 50 and \> 80 years
* BMI (Body Mass Index) \< 20 and \> 40kg/m2
* Intravascular fluid infusion within 24 hours before study
* Chronic non-steroidal anti-inflammatory drug use (more than 6month daily use)
* Rheumatoid arthritis
* Diabetes mellitus
* Psychiatric illness (intake of other psychiatric medication than selective serotonin reuptake inhibitors)
* Alcohol intake 5 U daily
* Contraindication to epidural catheter insertion
* Surgery not by project surgeon
* Participation in the other study
* Active malignancy
* Previous open knee surgery
The Effect of Futsal Training on Physical Fitness in Amateur Futsal Players

The goal of this observational study is to examine the effects of classical futsal training on physical fitness in amateur futsal players. The main question\[s\] it aims to answer are:

• Does classical futsal training have any effect on the physical fitness level of futsal players? Participants will be taken to the classical futsal training program for 8 weeks. Before and after 8 weeks, players will be evaluated for their physical fitness.

The study was planned to be carried out as a non-randomized clinical study with 30 athletes in the university futsal team.

All athletes will be evaluated at the beginning of the training and will continue their classical futsal training for 8 weeks.

The program to be applied in addition to routine training 2 times a week;

* It will begin with a 10-minute standard futsal workout warm-up. warm-up program; It will consist of light aerobic exercises and dynamic stretching of large muscle groups.
* After the warm-up period, all groups will participate in the standard 45-minute futsal training.
* Finally, the training will end with 5 minutes of cool-down exercises (dynamic stretching).

The first evaluation will be made 2 days before the athletes' routine training, and the next evaluations will be made at least 2 days after the last training.

Eligibility Criteria:
Inclusion Criteria:

* be between the ages of 18-25
* Playing in Istanbul Medipol University futsal team
* 2 days a week, 2 hours training for futsal or 1 game a week and 2 hours a week, 2 days a week

Exclusion Criteria:

* History of lower extremity injury or surgery within 6 months prior to the test
* Injury three months before the study,
* Failure to heal or complete rehabilitation of previous injury,
* Physical or mental conditions that prevent them from participating in technical and tactical futsal training and/or experimental training programs
* Two or more missed training sessions
Simulated Amniotic Fluid Solution in Neonates Recovering From GIT Surgeries

Amniotic fluid plays a significant role in fetal gut maturation and development. The human fetus swallows over 200 ml of amniotic fluid per kilogram of weight each day and such swallowing is essential for normal small bowel development.Growth factors found in the amniotic fluid have been shown to promote proliferation of fetal intestinal cells. As feeding intolerance is a common problem among neonates recovering from surgery for congenital bowel abnormalities, the investigators will study the role of enteral administration of simulated amniotic fluid solution in prevention of feeding intolerance and NEC in neonates recovering from GIT surgeries.

Neonates with congenital GIT anomalies will participate after being operated.

Participants will be followed for the duration of hospital stay until discharge or death.

Eligibility Criteria:
Inclusion Criteria:

* Neonates with operable congenital bowel abnormalities

Exclusion Criteria:

* Critically ill babies.
* Presence of any contraindications to enteral feeding
Integrating Pediatric Pharmacogenomic Testing Into the Canadian Health Care System

This project addresses the problem of adverse drug reactions in the three most frequently prescribed therapeutic classes of drugs in children: antibiotics, analgesics, and mental health medications.

We will conduct pilot testing of a pharmacogenomic testing panel and study how the tests and generated test results are utilized and understood by physicians, pharmacists, patients and their families.

The specific objectives are to:

1. Implement a pilot pharmacogenomics program to test medication safety and effectiveness of antibiotics, analgesics and mental health medication to enhance prescribing decision-making.
2. Develop data collection forms to collect necessary patient information from the prescribing physicians.
3. Develop pharmacogenomics reports to return results to physicians, pharmacists, patients and their families.
4. Determine how the tests and results are perceived and utilized by physicians, pharmacists, patients and their families.

Eligibility Criteria:
Inclusion Criteria:

* Participants will be enrolled if they can benefit from pharmacogenomic testing. This means their physician is considering the use of a drug that is part of the panels (analgesics, antibiotics, and mental health medication) or they are already using one.

Exclusion Criteria:

* Patients who do not speak or understand English.