cyrilzakka/clinical-trials huggingface dataset:
Tailoring Treatment in Colorectal Cancer

In this study, the investigators will establish a reliable method and logistic pipeline for personalized drug testing ex vivo using fresh tumor samples from colorectal cancer (CRC) patients. With this, the investigators aim to develop a novel predictive biomarker of immunotherapy response, by testing combinations of chemotherapies and chimeric antigen receptor (CAR) T cells. Critically, this affects a large subgroup of patients currently not considered to benefit from such treatment. To support the hypothesis, the project will make use of cutting-edge, cell-based functional diagnostics. Individual patients' cancer cells will be screened against a panel of chemotherapies and targeted therapies including CAR T cells, to assess the optimal combination of therapies to induce immunotherapy efficacy in otherwise unresponsive CRC.

Primary hypothesis: Drug screening of patient-derived organoids is a feasible method to identify effective and ineffective therapies for personalized colorectal cancer treatment.

Secondary hypothesis: Pre-treatment with cytotoxic agents can induce cellular immunotherapy efficacy against solid tumors in a colorectal cancer patient-derived organoid model.

Primary objective: To provide methodology and competencies for a clinical trial on drug screening on patient-derived organoids as an approach in personalized cancer treatment.

Secondary objective: To explore induction of cellular immunotherapy efficacy in colorectal cancer patient-derived organoids by chemotherapy or targeted agents.

Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed colorectal cancer scheduled for curative surgery and standard clinical follow-up.

Exclusion Criteria:

- Unable/unwilling to sign the informed consent form.
Results of Manual Therapy on Pulmonary Parameters

The main objective of this study is to evaluate the effectiveness of different manual techniques included traditionally on respiratory physical therapy

Randomized controlled trial. Participants are classified in two groups and they are assessed using pulmonary functions parameters and thoracic and spinal movements.

There are two interventions: placebo and a manual technique. Participants will be assessed again at the end of the study.

Eligibility Criteria:
Inclusion Criteria:

* subjects with respiratory conditions
* Must be able to do spirometry

Exclusion Criteria:

* subjects with acute processes in their pathologies
Saphenous Nerve Block: Single Shot Versus Continuous Infusion to Supplement a Continuous Sciatic Nerve Block After Major Ankle Surgery

The most useful method to manage pain after major ankle surgery is infusion of local analgesics with a catheter close to the sciatic nerve.

Sensation from the ankle are carried by three nerves: The tibial and peroneal nerve (unified in the sciatic nerve) and the saphenous nerve.

Study purpose is to test whether continuous infusion of local analgesics by saphenous nerve catheter provide a better treatment of pain in comparison with a single injection nerve block. In addition cost-effectiveness of the two methods are compared.

The 50 patients of the trial are randomized in clusters of ten. We intend to do a preliminary analysis of the data from the first 40 patients. However, it is not an interim analysis. Fifty patients will be included independent of the result of the preliminary analysis. The random allocation of the last 10 patients will also be double-blinded.

Major ankle surgery are known to be very painful the first 48 hours after the operation due to surgical oedema. This pain is difficult to control with systemic analgesics. Pain relief with systemic analgesics requires high doses of intravenous opioids and is associated with breakthrough pain and adverse effects of opioids (sedation, nausea, vomiting, obstipation, urinary retention, respiratory depression).

Continuous, peripheral nerve block with catheter technique for two days minimizes the need for systemic analgesics. Today such a continuous sciatic nerve block is part of the standard pain treatment after major ankle surgery on Aarhus University Hospital. Despite accurate placement of the catheter many patients are in great pain because the saphenous nerve remain unaffected. A single injection block relieve the pain but a block with Ropivacaine only last 8-15 hours.

Severe postoperative pain leads to high opioid dosages, cognitive blurring, nausea, vomiting, reduced ambulation, increased surgical stress response and increased morbidity. Pain problems and adverse effects prolongs postoperative observation time and maybe also time to discharge.

The aim of the study establish whether continuous saphenous nerve block is efficient (pain relief or reduced opioid consumption) and justified (cost-effectiveness analysis) compared with single injection block.

Eligibility Criteria:
Inclusion Criteria: Elective major ankle surgery

* total ankle arthroplasty
* subtalar fusion
* ankle fusion (non arthroscopic)

Exclusion Criteria:

* coagulation abnormalities
* infection in the region of needle insertion
* systemic infection
* preoperative consumption of high dose opioid
* preoperative sciatic or femoral nerve neuropathy
* preoperative sensory deficit in either of the lower extremities
* Charcot-Marie-Tooth disorder
* diabetic neuropathy
* severe peripheral vascular disease
* allergy to local anesthetics
* lack of understanding of Numeric Rank Scale (NRS)
* communication problems
* dementia
* body mass index above 35
* bilateral continuous sciatic nerve block
* lack of consent
THE EFFECT OF MINDFULNESS-BASED PRACTICES GIVEN TO NURSING

In our research, it is expected that the 'conscious awareness-based psychoeducation program' will be made to the nursing students who go into clinical practice, to increase the level of mindfulness of the students, to increase their level of compassion and compassion, and to reflect this awareness while providing nursing care. It is thought that it is important to evaluate the effects of mindfulness-based psychoeducation program practices on nursing care and to evaluate mindfulness-based psychoeducation program practices.

This study was planned as a randomized control study with an intervention group to determine the effect of mindfulness-based practices given to nursing students on compassion, compassion and nursing care.


Eligibility Criteria:
Inclusion Criteria:

* be over 18 years old
* become a nursing student
* Having successfully passed the internal medicine nursing course

Exclusion Criteria:

* not attending 1 session of the study
* unwillingness to quit
A Open Label Study in Previously Studied, SBC-103 Treatment Naïve MPS IIIB Subjects to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics/Efficacy of SBC-103 Administered Intravenously

This study evaluated the safety and tolerability of intravenous (IV) administration of SBC-103 in previously studied, SBC-103 treatment naïve patients with mucopolysaccharidosis III, type B (MPS IIIB, Sanfilippo B) who participated in the NGLU-CL01 study. The NGLU-CL01 study was a non-interventional study that evaluated structural brain abnormalities and blood brain barrier (BBB) integrity by magnetic resonance imaging (MRI) and cerebrospinal fluid/serum albumin index.


Eligibility Criteria:
Participants from NGU-CL01 study were enrolled into the NGLU-CL01-T study. Subjects who met all of the inclusion criteria and none of the exclusion criteria were eligible to participate in this study.
Optimizing Parameters of Low-Intensity Focused Ultrasound for Cortical Modulation in Stroke Patients

The purpose of this research study is to find out the optimal intensity and frequency of Low Intensity Focused Ultrasound (LIFU) that is safe and tolerable in people who have had a stroke.

Aim 1 is to determine the optimal intensity of Low Intensity Focused Ultrasound stimulation (LIFUS) in stroke patients in terms of safety. We will investigate the optimal spatial-peak temporal-average intensity/ISPTA in the range of 0(or sham) W/cm2 to 8 W/cm2. Safety will be investigated by assessing clinically detectable signs and symptoms by monitoring vital signs and surveying subjects with a questionnaire before and after each stimulation session, and additionally by detecting subclinical neuronal injury using MRI/DWI. Aim 1 requires up to 36 subjects.

Aim 2 is to determine the optimal frequency of LIFU stimulation in stroke patients in terms of cortical excitability. Stroke subjects undergo each of the 5 frequency levels (0.35 MHz; 0.5 MHz; 0.75 MHz, 1.0 MHz and 1.5 MHz) on 5 different days with at least one day washout. The intensity (ISPTA) will set up at the level that is determined from Aim 1. Cortical excitability is measured by the amplitude of motor evoked potentials (MEPs) induced by Transcranial Magnetic Stimulation (TMS) from the Abductor Pollicis Brevis (ABP) muscle of the affected side. MEPs will be recorded pre- and post-stimulation to determine the optimal intensity for maximal cortical excitability from the hemisphere where the lesion is located. Aim 2 requires 18 subjects.

Eligibility Criteria:
Inclusion Criteria:

1. ≥ 21 years old of any gender and race;
2. Clinical ischemic stroke or hemorrhagic (confirmed by CT or MRI) that occurred \>= 2 months ago
3. Predominantly unilateral motor impairment with FM-UE score ≤ 62/66;
4. MEPs are inducible from a hand muscle on the affected side (i.e. Abductor Pollicis Brevis (APB) muscle).

Exclusion Criteria:

1. Any concomitant neurological disorder affecting arm function;
2. Documented history of severe dementia with or without medication before stroke;
3. Subject is unable to do the motor learning practice at the baseline;
4. Presence of any MRI/TMS/ultrasonic stimulation risk factors: an electrically, magnetically, or mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, or any other electrically sensitive support system; non-fixed metal in any part of the body; pregnancy (the effect of TMS/ultrasonic stimulation on the fetus is unknown); no history of seizure before or after the stroke; preexisting scalp lesion or wound or bone defect or hemicraniectomy.
Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome

Participants with PCOS will be divided into two groups then each group will randomly recieve one of the following treatment

1. metformin will be adminstered in adose of 500 mg 3 times daily for 3 months to group B.
2. pioglitazone will be administered in adose of 30 mg dialy for 3 months to group A.
3. Induction of ovulation by clomiphene citate 50 mg tablets to all participants

Participants with PCOS will be divided into two groups then each group will randomly recieve one of the following treatment

1. metformin will be adminstered in adose of 500 mg 3 times daily for 3 months to group B.
2. pioglitazone will be administered in adose of 30 mg dialy for 3 months to group A.
3. Induction of ovulation by clomiphene citate 50 mg tablets once or twice dialy 12hours apart starting from the 3rd day of menstrual cycle and continue for five days during treatment with insulin sensitizing agents to group A and B.

Participants with oligomenorrhea will recieve two tablets of noreththisterone 5 mg tab every 12 hours for 5 days to allow for withdrawal bleeding before start ovulation induction

Eligibility Criteria:
Inclusion Criteria:

* women age 20_35
* BMI 18_29.9
* Women with PCOS(diagnosed by using Rotterdam criteria
* Infertility is cause for seeking tfeatment

Exclusion Criteria:

* Causes of infertility other than PCOS.
* patient refusal.
* Contraindication of any of the drugs used in the study
* Cause of oligo/anovulation other than PCOS
* Current or previous (within the last six month) use of oral contraceptives, glucocorticoids, antiandrogens, antidiabetics, antiobesity drugs or other hormonal drugs.
MR-Evaluation of Renal Function-After-Pancreas-transplantation

The purpose of this study is to evaluate the beneficial effect of pancreas transplantation for long term kidney function in patients undergoing single-pancreas transplantation.

Renal failure in patients who have performed a pancreas transplantation is a hazard for the outcome for these patients. The beneficial effect of pancreas transplantation for renal function is not clear. It is of major importance to early find patients who develops a decrease in renal function and start treatment early and closely monitor these patients in order to avoid further deteriorating renal function. In order to achieve this, there is a need for a easy, fast and sensitive method to evaluate renal function. In this study the investigators plan to use the non-invasive MR to evaluate changes in renal function.

Eligibility Criteria:
Inclusion Criteria:

* Patients with diabetes mellitus
* Patients undergoing a pancreas transplantation

Exclusion Criteria:

* Patients undergoing a pancreas transplantation and a renal transplantation at the same time.
Acetazolamide Facilitates Ventilator Weaning

Metabolic alkalosis(MA) is common metabolic disorder in ICU setting. MA could be cause of weaning failure or delay by depression of respiratory center. The purpose of this study is to evaluate that correction of MA by administration of acetazolamide facilitates weaning of mechanical ventilation.


Eligibility Criteria:
Inclusion Criteria:

* Patients on mechanical ventilation for at least 24 hours with an assisted mode and passed acute resuscitation and considered for weaning. (Definition of Weaning point:

  1. Oxygenation

     * FiO2 ≤ 0.4 \& PaO2 ≥ 60 mmHg

       * O2 index (PaO2/FiO2) ≥ 150

         * SaO2 \> 90%

           * PEEP ≤ 5 cmH2O

             * MN ≤ 15 L/min
  2. Vital sign

     * Stable BP: MAP ≥ 60 mmHg ((i.e., no epinephrine or norepinephrine \<0.2μg/kg/min, or equivalent dose vasopressin or phenylephrine)

       * HR ≤ 140bpm

         * 35 ≤ BT ≤ 38 ℃

           * RR ≤ 35/min
  3. Clinical status

     * resolution of acute disease process

       * no newly developed pulmonary infiltration

         * Ramsay sedation score 2\~4

           * Hb \> 7, pH \> 7.30, normal electrolyte

             * no active bleeding, no IICP, no bronchospasm, no CAD

               * no rescure or specific treatment (NO, prone, OP plan)
* ABGA : pH ≥ 7.43 and HCO3- ≥ 26mEq/L

Exclusion Criteria:

* Permanent ventilator dependency due to brainstem disease, diffuse cerebral disease, severe respiratory or neuromuscular disease
* Active bleeding, IICP, unstable coronary artery disease, bronchospasm, and rescue treatment (inhaled NO, prone), pre-op condition
* Contraindication to acetazolamide: renal insufficiency (creatinine clearance \<20 ml/min and/or renal replacement therapy), intolerance or allergy to acetazolamide or sulfonamides, hyperchloremic metabolic acidosis, hyponatremia (Na\<130), hypokalemia (K\<3.5), adrenal insufficiency.
* Diaphragm dysfunction : as diagnosed by fluoroscopy, nerve conduction velocity, USG, or overt paradoxical motion of the abdomen
Computerized Risk Assessment in an Employee Population

This is a study to determine whether a computerized risk assessment and focused patient provider interaction can improve health outcomes in an employee population.

The overall goal of the proposed research is to test the effectiveness of a theoretically-based interactive behavioral and health risk assessment system to improve the mental and physical health outcomes of the primary care provided for the adult multicultural members of a university health center-employee-based practice. The new system will include:

1. administration of a computerized behavioral and health risk assessment,
2. calculation of an individualized risk profile for each patient participant,
3. individual patient computerized video training in interaction focused on the risk profile,
4. physician training in patient-provider interaction, motivational interviewing and counseling, and in referral and triage focused on the risk profile, and
5. development of a negotiated care plan between patient and clinician for follow-up care.

Expected outcomes include changes in: risk category scores, utilization patterns, costs for health care services, and health stage of change indicators. Expected impacts (mediating variables) are: compliance with recommendations, health locus of control, differences in patient-provider interaction patterns and patient and clinician satisfaction. If successful, this methodology would contribute significantly to the health promotion goals of Healthy People 2010 and provide much needed evidence of how a behavioral and health risk assessment system can help to reduce ethnic health disparities of multi-cultural populations. This proposal is responsive to CDC's RFA for Health Promotion in the Workplace; in particular it responds to requests for strategy #6: Identification and evaluation of public health informatics and communication strategies and tools to improve health decisions, health alerting, health literacy, or health assessment among employees and employer.

Eligibility Criteria:
Inclusion Criteria:

* Employees who use University of New Mexico providers for medical care
Diabetes Training Program for Health Professionals From Hermosillo, Sonora

Primary health care is the medical assistance available to all individuals in a community and is considered the core of the health system. Diabetes, among other chronic diseases, is a common reason for medical consultation in primary health care. Worldwide and in Mexico, the prevalence of diabetes has been increasing in recent decades, which also leads to an increase in the number of deaths. On the other hand, the annual cost of medical care for diabetes in the country has increased due to the exacerbation of complications and comorbidities associated, which are presented, among other causes, by a deficiency of knowledge in the diagnosis, evaluation, management and follow-up of type 2 diabetes, of health professionals (doctors, nurses, nutritionists) working in primary health care.

The present study will allow evaluating the effect of a training program, is a single-cohort clinical study with pre- and post-intervention measurements lasting 6 weeks, including the initial and final measurements of health professionals currently working in primary health care of Hermosillo Sonora.

The study aims to improve knowledge in diabetes through the design and evaluation of a training program in health professionals (doctors, nurses and nutritionists) in primary health care.

The hypothesis of the study is that the training program in diabetes aimed doctors, nurses and nutritionists in primary health care will significantly increase knowledge in diabetes.

Eligibility Criteria:
Inclusion Criteria:

* Physicians, nurses and nutritionists of primary health care in Hermosillo, Sonora.
* Belonging to the health jurisdiction and the general hospital of the state
* That provide consultation to patients with diabetes
* Age 20 years and less than 65
* Desire of participate
* Sign up the consent form

Exclusion Criteria:

* Do not meet the inclusion criteria
Comparison of Epithelial Lining Fluid and Blood Pharmacokinetics and Pharmacodynamics of Intravenous and Intravenous Plus Nebulized Polymyxin B in Multidrug Resistant Bacteria Ventilator-associated Pneumonia Patients

The goal of this observational study is to investigate whether intravenous polymyxin B combined with nebulisation achieves better antimicrobial efficacy and clinical outcomes than intravenous use alone in patients with multidrug-resistant gram-negative bacilli infected with ventilator-associated pneumonia. The main questions it aims to answer are:

* When using intravenous polymyxin B to treat patients with ventilator-associated pneumonia caused by multidrug-resistant bacteria in clinical practice, is it necessary to assist with polymyxin B nebulization therapy？
* If necessary, how much dose of nebulization is better? Participants will be divided into two groups based on whether they have received nebulization treatment with polymyxin B in clinical practice. Blood and alveolar lavage fluid samples will be collected after the first dose injection and reaching the steady-state dose, and the drug concentration differences in blood and ELF will be measured in patients who have received intravenous injection of polymyxin B alone and those who have received adjuvant nebulization of polymyxin B, as well as differences in clinical outcomes and side effects.

Researchers will compare the differences in blood and ELF drug concentrations, clinical outcomes, and incidence of side effects between two groups of patients, to see if is it necessary to assist with polymyxin B nebulization therapy in patients with multidrug-resistant gram-negative bacilli infected with ventilator-associated pneumonia.


Eligibility Criteria:
Inclusion Criteria:

* 18-80 years old;
* ICU patients;
* Patients with MDR-infected VAP were diagnosed by etiological culture results;
* Expect to receive at least 6 doses (3 days) of polymyxin B;
* Obtain informed consent;

Exclusion Criteria:

* The patient has a history of severe hypersensitivity to polymyxin B;
* Patients cannot tolerate alveolar lavage;
* Oncology patients,includes hematologic malignancies;
* Pregnant or lactating women;
* Patients with other conditions that the investigators consider unsuitable for enrollment;
The Effect of "Jinchuang Ointment" (JCO) on the Treatment of Wounds in Patients With Hansen's Disease.

This study aimed to evaluate the effect of a Chinese herb complex "Jinchuang ointment" (JCO) on the treatment of chronic nonhealing wounds in patients with Hansen's disease and its mechanism.

20 patients who were hospitalized at Lo-Sheng Sanatorium, Ministry of Health and Welfare, were recruited. Ulcers were treated in this study using the four-step wound care guidelines, observation, rinsing, cleaning, and dressing, published by the Taiwan Food and Drug Administration. Besides, JCO was applied once a day on the wounds.

Basic data of each case were collected, and a monthly wound record was used to follow the condition of the wound healing of these patients.

Eligibility Criteria:
Inclusion Criteria:

* Hanson's patients
* Meet the definition of chronic wound

Exclusion Criteria:

* Kidney disease
* Parathyroid disease
* Malignant tumors.