cyrilzakka/clinical-trials huggingface dataset:
IVM Versus IVF: Differences in Patients' Emotional Adjustment and Quality of Life

Patients who undergo in vitro fertilization with or without intracytoplasmic sperm injection (IVF / ICSI) often experience an impact on their quality of life and emotional maladjustment to treatment and outcome. Multiple contributors to this negative impact have been identified, including interference with professional activities, expenses related to fertility treatment and hormonal side effects. In-vitro maturation (IVM) of human oocytes obtained from minimally stimulated or unstimulated ovaries offers a more "patient friendly" treatment option than the conventional ovarian stimulation protocols for Assisted Reproductive Technology (ART) treatment. Historically, IVM has been offered to women with increased ovarian response (so-called "high responders"), typically women with polycystic ovaries (PCO/PCOS), who are at increased risk for ovarian hyperstimulation syndrome (OHSS) if conventional ART protocols are used. IVM treatment programs are characterised by a minimal administration of fertility hormones, are less disruptive to patients' daily life through a reduced need for hormonal and ultrasound monitoring, avoid a range of minor and major complications because of the reduced hormonal burden of this procedure, and aim to reduce the total cost for of infertility treatment.

To facilitate the application of IVM as a treatment that can potentially improve the overall patient experience, a study comparing the psychological impact of a conventional ovarian stimulation protocol versus an IVM protocol will be conducted; furthermore, a study investigating the differences in quality of life between the two subgroups will also be performed.

Socio-demographic data, medical characteristics and the following questionnaires will be collected: Specific questions for patients with fertility problems (FertiQol); Hospital Anxiety and Depression Scale (HAD) and an instrument to measure side effects designed by the research group. The study group (IVF patients and IVM patients) will be evaluated at three predefined time points: at intake, after oocyte collection and when the outcome after the first embryo transfer is known.

Descriptive analysis, intergroup comparisons and explanatory/predictive model of the dependent variables (quality of life, emotional adjustment) will be performed.


Eligibility Criteria:
Inclusion Criteria:

* Heterosexual or homosexual women enrolled to undergo ART treatment
* Patients with polycystic ovarian morphology (12 or more small follicles observed during a baseline pelvic ultrasound scan) or polycystic ovary syndrome (PCOS) (Rotterdam criteria, 2003)

Exclusion Criteria:

* Medical contra-indication for pregnancy
* High (\>grade 2) grade endometriosis
* Patients who have previously undergone ART treatment
* Patients who require ART with PGD
* In vitro fertilisation with sperm retrieved through testicular biopsy
* Singles without a partner
* Couples who because of the language barrier (poor knowledge of Dutch, French or English) cannot reliably fill out the questionnaire.
K01 Impacts of Lingual Endurance Exercise

Swallowing impairments (dysphagia) frequently occur after stroke and have devastating consequences on overall health and quality of life, and long-term deficits in swallow function also increase risk of morbidity (e.g. depression) and mortality (i.e. aspiration pneumonia). As such, rehabilitation of swallow function to improve safety and efficiency of swallowing is essential in this population. This study aims to: 1) Provide preliminary data to evaluate the effect of a novel lingual endurance exercise on swallow function in individuals with post-stroke dysphagia; and 2) Collect preliminary data regarding changes in white matter tract diffusion and cortical thickness and from MRI data to better understand effects of lingual exercise training on neuroplasticity.

This pilot trial will evaluate the effect of lingual endurance exercise (vs sham exercise) on recovery of swallow function after stroke. The Primary Aim of this study is to evaluate effects of lingual endurance exercise vs sham on swallow function in individuals with post-stroke dysphagia. The investigators hypothesize that lingual endurance training will result in greater improvement in measures of oral swallow physiology as compared to sham. Regardless of outcome, this dataset will provide innovative and highly novel information regarding the relationship between lingual function, swallowing impairments, and cortical representation of dysphagia in a post stroke population. These pilot data will be essential in providing sufficient power for designing an R01 Phase II intervention trial to investigate how to maximize gains with timing and intensity of therapy delivery to better recover swallow function after stroke.

Eligibility Criteria:
Inclusion Criteria:

* 1) 3-6 months since most recent diagnosis of ischemic, confirmed from clinical imaging) with or without small hemorrhagic transformation (HI-1)
* 2) Have some indication of on-going swallowing issues
* 3) English Speaking

Exclusion Criteria:

* 1) ≤18 years of age
* 2) history of dysphagia prior to or after the stroke caused by any of the following conditions: gastrointestinal disease, traumatic brain injury, head and neck cancer, surgery involving the pharynx or larynx
* 3) history of other neurological disease (i.e. multiple sclerosis, ALS, Parkinson's, dementia).
* 4) Medium to large hemorrhagic transformation/involvement documented on clinical stroke imaging 5) 5) History of temporomandibular joint and muscle disorders (also known as TMJ).
Pregnancy and Use of Psychoactive Substances: The Influence of Representations of Care on Care.

It is observed that pregnant women using psychoactive substance (s) have a more random and more accidental pregnancy follow-up than women with no addictive problems.

The consumption approach can be either omitted during the pregnancy monitoring, or entrusted to the course or more often in late pregnancy or occurs more brutally during delivery at the time of complications (neonatal or obstetric). In this context, health professionals are looking for levers that allow women to take appropriate care quickly.

This difficulty of access to care questions us and all the more because the time of the pregnancy is a moment of important psychic reorganization conducive to modify its habits, to change its glance on its consumptions and thus to start a care concerning addiction.

Invesigators hypothesize that this population has less access to medical care during pregnancy for fear of stigmatization by the health care provider.

Invesigators propose a multicenter qualitative study based on individual clinical interviews to collect the testimony of women who used psychoactive substance (s) during their pregnancy.

The purpose of this work is to identify ways to improve the multidisciplinary medical management of these women by focusing on the representations they can make care of.


Eligibility Criteria:
Inclusion Criteria:

* Major patients
* Pregnant or having given birth since \<28 days
* Having used (whether declared or discovered incidentally) - regardless of the amount of psychoactive substance (s) during pregnancy: alcohol, and / or heroin or OST, and / or cannabis, and / or psychostimulants (cocaine, ecstasy, amphetamines)
* Followed or not in addictology during pregnancy

Exclusion Criteria:

* Minor patients
* Patients under legal protection (guardianship, guardianship)
* Linguistic obstacle
* Psychiatric pathology decompensated at the time of the meeting
* Women who only used tobacco regularly during pregnancy
* Women who have only regularly used psychoactive drugs and / or licit opiates (excluding prescription replacement products) during pregnancy
BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival

Primary objective To determine BRCA1 and BRCA2 variants in 250 Romanian women with breast/ovarian cancer selected for likeliness to harbor germline mutations in these genes by specific criteria for high-risk status including age at disease onset.

Secondary objective Considering the fact that BRCA testing is not a routine procedure in Romania and mutation prevalence varies in different populations, we intend to look for the founder mutation in our population, running full BRCA genes sequencing to a representative population sample. This would allow a more targeted approach to real-life practice and would ensure personalized solutions for every patient in need.


Eligibility Criteria:
Inclusion Criteria:

Categories of patients to be recruited for complete sequencing of all BRCA1 and BRCA2 exons are subjects who have been diagnosed with breast or ovarion cancer and who are:

1)40 years of age or younger 2)Triple negative breast cancer diagnosed before 50 years of age 3)Male with breast cancer 4)Bilateral breast cancer, first tumor diagnosed before 50 years of age 5)2) + 50 years of age or younger with at least one (first degree) relative diagnosed with breast cancer at 50 years of age or younger or a first degree relative with ovarian cancer 6)of any age with 2 or more relatives with breast cancer 7)of any age with 2 or more relatives with ovarian cancer 8)of any age with a personal history of ovarian cancer, tuba or peritoneal carcinoma 9)Two patients in same branch of the family, Prostate ca \< 60 yr and 1st degree relative with BC \< 50 yr 10)Two or more 1st and 2nd degree relatives of a patient with breast cancer, at least one of them \<50 yr 11)of any age with a family history of male breast cancer or are at increased risk of having a BRCA mutation based on BRCAPRO or Tyrer-Cuzick models

Exclusion Criteria:

-
Impaired Vigilance, and Its Effects on Cognition and Behavior

Fifty healthy, young participants (10 male, 40 female) completed two 3-hour study sessions that were at least five days apart. The first session was a baseline. The sleep intervention took place on the night prior to Session 2, where the amount of time in bed was manipulated to be 60-130% of the individual's habitual sleep time. Within both sessions, subjective (Stanford Sleepiness Scale, SSS) and objective (Psychomotor Vigilance Test, PVT) alertness were measured. During the middle of each session, a 40-minute ad libitum meal opportunity allowed participants to eat from eight different food items. Food healthfulness, caloric density, distribution and number of calories were measured and compared to alertness levels.


Eligibility Criteria:
Inclusion Criteria:

* Age: 18-45 years
* BMI: 20-29 kg/m²
* Eat breakfast at least 5 days per week
* Wake time occurs between 5\&10AM at least 5 days per week
* Time in bed for sleep between 5\&10 hours at least 5 days per week

Exclusion Criteria:

* Dietary restrictions that prohibit them from selecting one of the food choices offered in the study (e.g., gluten allergies, diabetes, vegan diet, dairy avoidance, allergies to the respective food choices available),
* are currently on a calorie-restricted diet, or
* are currently at a weight that is less than 20% of their highest weight within the last three years.
* Participation in shift work within 7 nights of the experiment
* Diagnosed as having severe sleep apnea syndrome, narcolepsy or chronic insomnia
* Diagnosed as having an eating disorder
* Active serious health condition
* Regularly taking vigilance-related medication (e.g., ADHD prescribed medication)
* Typically consume more than 600 mg of coffee or more than 10 cigarettes per day
Hybrid Intelligence for Trustable Diagnosis and Patient Management of Prostate Cancer (HIT-PIRADS)

The purpose of this study is to develop a new way to diagnose prostate cancer through the use of artificial intelligence. The goal is for this new method to reduce delays in diagnoses and to avoid invasive procedures such as biopsies.

The overall goal of this project is to create a diagnosis and patient management strategy (called HIT-PIRADS) for prostate cancer (PCa) that will significantly increase positive predictive value (PPV) for clinically significant PCa detection while minimizing unnecessary prostate biopsies and related morbidities. Due to its interpretable nature and bias correction paradigm, the AI system will generate predictions that physicians can trust. One of the immediate outcomes of the system will be a reproducible risk scoring system that can be used in community hospitals and locales without MRI-subspeciality genitourinary trained radiologists to improve the accuracy of prostate imaging nationwide. In the long term, the investigators expect HIT-PIRADS to be widely adopted in clinics and trigger other treatment and prevention strategies to be developed based on HIT-PIRADS.

Eligibility Criteria:
Inclusion Criteria:

* Elevated PSA (4.0-10.0 ng/ml) or abnormal digital rectal exam with PSA of 2.00-10.00 ng/ml as indicated in the patient's lab report.
* Patients must be biopsy naïve, confirmed with patient or medical record.
* Patients must be male, ≥18 and ≤ 89 years of age.
* Patient must have a life expectancy ≥10 years, determined by PI.
* Patients must exhibit an ECOG performance status of 0-2, as noted in their medical record.

Exclusion Criteria:

* Patients who are on a 5-α-reductase inhibitor within 12 months of enrollment, as confirmed by medical record.
* Patients who have had a prostate infection within 1 month of enrollment, as confirmed by medical record.
* Patients who are receiving or who received prostate cancer treatment (e.g., androgen deprivation therapy, surgery, radiation therapy or adjuvant/neoadjuvant therapy with investigational drugs) per their medical record.
* Patients who've had an invasive urological procedure within 1 month of enrollment, as confirmed by their medical record and patient reporting.
* Patients with no access to the rectum for a transrectal ultrasound, as determined by the Urologist.
* Patients with a contraindication to magnetic resonance imaging (MRI).
* Vulnerable populations: Prisoners or adult men \>89 years old.
3D Non-invasive Myocardial Electrical Propagation Mapping as a New Tool to Predict Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is very common. The thickened heart muscle can disrupt the normal functioning of the heart's electrical system, resulting in fast or irregular heartbeats. Today, there are no reliable means to identify HCM patients at risk of sudden death. The CardioInsight™ has recently been developed by Medtronic for non-invasive advanced cardiac mapping system. The CardioInsight™ Noninvasive 3D Mapping System is a non-invasive mapping system that collects chest ECG signals and combines these signals with CT scan data to produce and display simultaneous, bi-atrial and biventricular, 3-D cardiac maps.

It is a monocentric, prospective, comparative and analytical study. 20 HCM patients will be recruited in the National Reference Center for inherited cardiac diseases of Lyon. The 3D-propagation maps of 10 well phenotyped and genotyped HCM patients with previous VF (ventricular fibrillation) will be compared to 10 HCM patients without previous VF.

After consent signed, Holter ECG, scanner and CardioInsightTM 3D_ECG mapping will be planned in the month following the inclusion. 12-lead ECG, 24h holter ECG, cardiac scanner will be performed as standard procedure of each center in the current health care of the patient.

The widespread screening of HCM patients with 3D high-density noninvasive mapping should improve the risk-benefit ratio of implantable defibrillator therapy. It is expected that more patients at risk will benefit from this device.


Eligibility Criteria:
Inclusion criteria :

* HCM patient confirmed by echocardiogram.
* Patient who signed the consent.
* Patient benefiting from a social insurance system or a similar system

Exclusion Criteria:

* pregnant women,
* left ventricular dilation (diastolic \>60 mm diameter) and/or left ventricular systolic dysfunction (LVEF \<55%),
* prior cardiac surgery,
* atrial fibrillation,
* renal disease (serum creatinine \>2.0 mg/dl),
* primary cardiac valve disease
* coronary artery disease
* Previous recent cardiac scan
Comparative Effects of Oscillatory Mobilizations and Mckenzie Retraction Exercises on Mechanical Neck Pain

The neck pain is a public health problem and a common source of disability in the general population. Its exact pathology remains obscure, but the source of symptoms has been asserted to involve mechanical dysfunction of the cervical spine, particularly the zygoapophysial joints. Among the diversity of neck pain, mechanical neck pain is the most common type, with the pain primarily confined in the area on the posterior aspect of the neck that can be exacerbated by neck movements or by sustained neck postures. The usual clinical presentation of this mechanical neck pain is a reduction in mobility of either a single segment or multiple segments of the cervical spine in association with pain. This study will be a randomized control trial and will be conducted at Arif Memorial Teaching Hospital Lahore. The study will be completed within the time duration of six months. Convenience sampling technique will be used to collect data. A sample size of 30 patients(15 in each group) which will fulfill inclusion criteria will be taken in the study. Participants will be divided into two groups. Both Groups will be given conventional physical therapy and postural correction education. Group A will be provide oscillatory mobilizations. The following grades will be use: grades I and II for pain and grades III and IV to increase joint range of motion. This oscillatory mobilization will perform at a rate of 2-3 oscillations per second. and a frequency of 3-4 mobilization of the joint lasting approximately 30 sec each.

The rest time between each mobilization will be one minute for 5 days a week for four weeks , while group B will be treat withmckenzie retraction exercises in which foursets of 10-15 repetitions with 1-2 minutes rest between each set for 5 days a week during four weeks. Data will collect by using tools like numeric pain rating scale to measure pain, universal goniometer will be use for range of motion and disability level will be record pre and post treatment by using neck disability index. Then data will analyzed by using SPSS.


Eligibility Criteria:
Inclusion Criteria:

Patient with primary complaint of non specific neck pain. Pain of sufficient intensity (greater than 2 out of 10 on numerical pain scale) · Pain and stiffness for at least 2 weeks Pain aggravated by neck movement ·

Exclusion Criteria:

History of orthopedic surgery to the neck and shoulder and Temporo-mandibular Joint neurological symptoms due to cervical dysfunction History of Carcinoma Progressive neurological deficits
Positive Action for Today's Health

Regular moderate and vigorous intensity physical activity (PA) is inversely related with obesity, however, few adults are successful in incorporating sufficient PA into their daily lives. Minority and lower-income adults have among the highest obesity rates and lowest levels of regular PA. Increasing environmental supports for safe and convenient places for PA is an emerging public health strategy for PA interventions. Preliminary data by Wilson (PI) and colleagues has revealed through focus groups that low-income minority adults would like to increase the safe places for PA (areas free from crime, containment of stray dogs, increased police patrol) and access to PA (sidewalks/trails and expand opportunities for PA) in their community. In addition, the results of the investigators' preliminary studies suggest that African Americans had psychosocial barriers to PA that included lack of self-motivation, cultural body image issues, and lack of time due to family obligations. The present proposal is innovative in that it specifically tests the efficacy of an intervention that includes both patrolled-walking and social marketing elements to increase PA in low-income African Americans. Three communities will be randomized to receive one of three programs: a police patrolled-walking program plus social marketing intervention, a police patrolled-walking only intervention, or no walking intervention (general health education only; N=390; 130/group). The 24-month intervention will focus on increasing safety (training community leaders to serve as walking captains, hiring off-duty police officers to patrol the walking program, and containing stray dogs), increasing access for PA (marking a walking route), and will include a tailored social marketing campaign for increasing PA (in one intervention community). The investigators will collect data for PA (7-day accelerometer estimates, 4-week PA history), body composition, blood pressure, psychosocial measures, and perceptions of environmental supports for safety and access for PA at baseline, 6-,12-,18-, and 24-months. The primary hypotheses are that the patrolled-walking plus social marketing intervention will result in greater increases in moderate and vigorous PA as compared to a patrolled walking only intervention or no-intervention by 12-months and that these effects will be maintained at 18-month and 24-month assessments.


Eligibility Criteria:
Inclusion Criteria:

* African American (3 of 4 grandparents are of African Descent)
* Lives in designated census area
* No plans to move in the next two years
* Has no medical condition that would limit participation in moderate intensity exercise including life-threatening illness (e.g., immobile, severely disabled, or bed ridden)
* Available and able to participate in measures and intervention activities over the next 2 years

Exclusion Criteria:

* Extreme Blood Pressure and/or Blood Glucose levels
* Unable to take a brisk, 30-minute walk