cyrilzakka/clinical-trials huggingface dataset:
Relationship Between Pelvic Tilt and Sit to Stand Task in Stroke Patients

The purpose of this study is to assess and determine the influence of pelvic inclination on sit to stand task in stroke patients.

There is a crucial need to have a better understanding of effect of pelvic inclination on sit to stand activity and to know the important factors to be considered to improve the patients' treatment and performance. Forty five participants are recruiting to assess the pelvic tilt angles in stroke patients during sitting position and to analyze the influence of pelvic tilt angles on ability to perform sit to stand task during rising from a chair in stroke patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients' age ranged from 45-60 years old.
* Normal body weight with a body mass index (BMI) ranged from 18.5 to 24.9 kg/m2.
* Patients' had the ability to maintain sitting position without using any aids.
* Patients' had the ability to stand from sitting five times independently.
* Cooperative patients with ability to understand instructions and follow simple verbal commands.
* The duration of illness was from six months to 2 years.
* The degree of the paretic lower limb spasticity ranged between (1:1+) according to the Modified Ashworth Scale.
* The degree of the paretic lower limb weakness was not less than grade 3 according to group muscle testing.

Exclusion Criteria:

* History of previous strokes and other neurological disorders.
* Visual, auditory and vestibular deficits.
* Cognitive impairments and language deficits.
* Leg length discrepancy is more than 0.5 cm.
* Previous history of orthopedic conditions in back or lower limbs (e.g. low back pain, fractures, deformities and surgeries).
Comparison of The Continous Suprainguinal Fascia Iliaca Compartment Block and Continous Epidural

This study evaluates the effectiveness of postoperative analgesia quality, Interleukin-6, Hemodynamic stability and QoR-40 of continuous Suprainguinal Fascia Iliaca Compartment Block (S-FICB) compared with continuous epidural in patients undergoing cephalomedullary nailing surgery.

Half of participants will receive continuous S-FICB with patient control regional analgesia using ropivacaine 0.2% continue 2ml/hr and demand dose 5ml as needed, while the other half will receive continuous epidural with patient control epidural analgesia using same regimen.

The Continuous Suprainguinal Fascia Iliaca Compartment Block (S-FICB) and continuous epidural are regional anaesthesia that can be used to relieve postoperative pain of femur surgery. But there are few studies have been done to compare both techniques.

The S-FICB is an alternate peripheral nerve block technique using local anaesthetic administered into the fascia iliaca compartment at the inguinal region which targets the femoral, obturator and lateral femoral cutaneous nerves.

The epidural is well known and proven to have an adequate analgesia effect using local anaesthetic in the epidural region targeted for femur surgery.

Based on previous studies, the effectiveness of the S-FICB single shot was no longer than 18 hours. Then we choose to continue S-FICB to find out how adequate it is. The S-FICB with ropivacaine has a proven anti-inflammatory effect for the first 24 hours postoperative.

Eligibility Criteria:
Inclusion Criteria:

1. Patients is planned for cephalomedullary nailing surgery
2. Patients with BMI 18 - 30 kg/m2
3. Patients with ASA physical status I - III

Exclusion Criteria:

1. Patients with contraindications to regional anesthesia
2. Patients with mental disorders or psychiatric disorders
3. Patients have a history of allergy to the local anesthetic drug
4. Patients or family refused to participate in the study
Breath Gas Analysis for the Diagnosis of Breast Cancer

The volatile content of the exhaled breath gas of mamma carcinoma patients will be chemically analyzed by proton-transfer-reaction time of flight mass spectrometry.

The goal of the study is to determine typical breath gas components that allow to distinguish patients with mamma carcinoma from women without carcinoma. Further, the investigators will test whether these breath gas markers can be used as tumor markers, which change in a typical manner during the progress of the disease. Finally the data will be investigated for the presence of marker components, that identify patients who will develop metastasis.


Eligibility Criteria:
Inclusion Criteria:

* Mamma carcinoma diagnosed by histology (cases)
* Mamma carcinoma excluded by radiology (controls)
* At the time of diagnosis before surgery
* At the beginning and during chemotherapy;

Exclusion Criteria:

* No informed consent form singed
Spatial Profile of Tumors

The research project focuses on analyzing the spatial organization of cells within various solid tumors, utilizing advanced technologies enabling in-depth multi-parametric analysis of tumor and immune cells. The primary objective is to understand the spatial distribution of cellular subpopulations within each type of tumor, while secondary objectives include correlating these data with clinical aspects and identifying potential therapeutic targets. The study involves 1000 patients with primary or metastatic tumors and spans a duration of 5 years, from 2024 to 2028. No experimental treatments are planned; rather, only spatial imaging analyses with multiple markers will be conducted. Data analysis involves descriptive statistical methods and hypothesis testing to generate hypotheses for subsequent studies. The analyses will be performed using SPSS® version 21.0 software for Windows®.


Eligibility Criteria:
Inclusion Criteria:

* male or female subjects aged 18 years
* primary or metastatic tumors Diagnosed by histology and/or radiological evidence, RNM, or endoscopic
* signature of informed consent
* substitute declaration to the consent form where applicable

Exclusion Criteria:

* previous unrelated tumour disease
* significant acute or chronic infections (HIV, HCV and HBV infections) and/or ongoing bacterial and viral infections
* active autoimmune disease
* pregnant or breastfeeding
* patients who do not sign informed consent
Antimicrobial Drug Use and Resistant Staphylococcus Aureus

The purpose of this investigation is to study the relationships between antimicrobial stewardship program efforts, antimicrobial drug use, and infection control efforts to the incidence rates of hospital acquired infections with Staphylococcus aureus in a sample of US academic medical center hospitals.

Hospitalized patients can become infected with a variety of microorganisms, but infections caused by Staphylococcus aureus (i.e., "staph" infections) are particularly common. The main strategy to reduce the number of patients infected with Staph. aureus is to decrease cross-transmission from one patient to another. In addition, increasing evidence suggests that improvements in antimicrobial drug use--promoted by hospital Antimicrobial Stewardship programs (ASPs) -- may also favorably impact rates of Staph. aureus infections. While many Staphylococcal strains remain susceptible to an old drug called methicillin (methicillin-susceptible Staph aureus, or MSSA), many Staph. aureus are methicillin-resistant (MRSA). The drug of choice for MRSA has historically been vancomycin, and vancomycin is now the most commonly prescribed antibiotic in US teaching hospitals. Vancomycin-resistant Staph. aureus (VRSA) is still uncommon, but some Staph. aureus are developing "low level" resistance to vancomycin. These strains are often called S. aureus with MIC "creep" to vancomycin (SA-MICcreep), and Staphylococcus aureus with Heterogeneous Resistance to Vancomycin (hVISA), but the epidemiology, clinical significance and risk factors for these organisms are not well described. We will survey UHC participating hospitals to learn more about these organisms, the drug and ASP related risk factors, and whether hospitals are trying to identify these organisms.

Eligibility Criteria:
Inclusion Criteria:

* NA

Exclusion Criteria:

* NA
Prognosis Study of Different Anterior Cruciate Ligament Surgery Methods

From June 1, 2016, to July 1, 2017, a total of 406 patients with ACL rupture were randomly assigned to three different ACL surgeries: anatomical single-bundle, central axial single-bundle and double-bundle. A prospective randomized cohort study was conducted.


Eligibility Criteria:
Inclusion Criteria:

1. Age from 18-45.
2. ACL rupture confirmed by both physical examination and MRI.
3. Surgery done by senior doctor.
4. Using STG as autograft.

Exclusion Criteria:

1. With bilateral acl rupture.
2. Second injury.
3. Previous surgery in extremity.
4. With OA.
Effect of Liraglutide on the Metabolic Profile in Patients With Type 2 Diabetes and Cardiovascular Disease

In an unbiased metabolomics approach with subsequent pathway analyses, the current study seeks to examine the effect of Liraglutide treatment on the metabolic signature in treated patients as well as the effect of Liraglutide on various echocardiographic parameters of cardiac function and rhythm profile, thus paving the way for future research to explain the effects of Liraglutide on cardiovascular mortality and overall mortality in treated patients.


Eligibility Criteria:
Inclusion Criteria:

1. Type 2 diabetes
2. Serum levels of HbA1c ≥ 7,0%
3. Age ≥ 18 years
4. Patients with existing cardiovascular disease: coronary heart disease, cerebrovascular disease, peripheral vascular disease, chronic kidney disease of stage III or chronic heart failure of NYHA II or III)
5. Written informed consent prior to study participation

Exclusion Criteria:

1. Type 1 diabetes
2. Treatment with GLP-1 receptor agonists or DPP-4 inhibitors within the last 4 weeks
3. Patients with familiar or personal history of multiple endocrine neoplasia-type 2 or medullary C-cell cancer
4. Renal impairment (eGFR \< 30 mL/min)
5. Occurrence of acute vascular events within 6 weeks before screening and randomization
6. Known or suspected hypersensitivity to Liraglutide
7. Pregnant females as determined by positive (serum or urine) hCG test at Screening or prior to dosing. Participants of child-bearing age should use adequate contraception as defined in the study protocol.
8. Lactating females
9. The subject has a history of any other illness, which, in the opinion of the Investigator, might pose an unacceptable risk by administering study medication.
10. The subject received an investigational drug within 30 days prior to inclusion into this study.
11. The subject has any current or past medical condition and/or required medication to treat a condition that could affect the evaluation of the study.
12. The subject is unwilling or unable to follow the procedures outlined in the protocol.
13. The subject is mentally or legally incapacitated.
Computer Aided Evaluation of Orbital Volume

A retrospective review to assess the performance and clinical predictive value of a novel software program (Maxillo) designed to perform complex volumetric analysis with application in the field of orbital trauma.

The concept of open reduction and internal fixation of large and complex traumatic orbital deformities is well established. It is known that successful orbital reconstruction hinges upon restoration of native orbital volume in order to establish pre-morbid function and avoid long-term complications. To date, a facile, reliable, and reproducible method to measure orbital volume has not been rendered, despite numerous approaches. The objective of this study is to assess the performance and clinical predictive value of a novel software program designed to perform complex volumetric analysis with application in the field of orbital trauma.

Eligibility Criteria:
Inclusion Criteria:

* Chart reviews of patients at UCDMC with orbital trauma and having operative repair of the orbital fractures with post-reduction imaging included.

Exclusion Criteria:

* Absences of post-operative imaging
Musculoskeletal Pain of Neck and Shoulder Area in Female Office Workers: Relations Between Muscle Tone, Stiffness, Pain-pressure Threshold, Self-reported Pain Intensity and Physical Activity.

The objective of this study is to determine the differences between neck and shoulder region skeletal muscle tone, stifness, pain-pressure threshold, self-reported pain intensity and physical activity in female office workers. 50-100 participants aged 20-60 are anticipated.

The objective of this study is to determine the differences between neck and shoulder region skeletal muscle tone, stifness, pain-pressure threshold, self-reported pain intensity and physical activity.

Participants: 50-100 subjects, all female, aged 20-60 are anticipated.

Methods: Skeletal muscle tone and stiffness are measured using myotonometry. Pain-pressure threshold is measured using algometry. Prevalence of neck and shoulder area musculoskeletal pain is recorded using Nordic questionnaire. Self-reported pain intensity is measured using VAS scale. Self-reported physical activity is recorded using Baecke physical activity questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* Office work (at least 4 day per week, 8 hours a day with over 50% working with a computer)

Exclusion Criteria:

* Prior neck trauma, neurological or oncological conditions, recent use of muscle relaxants or painkillers, obesity (BMI of \>30)
Edaravone Dexborneol for Treatment of Hypertensive Intracerebral Hemorrhage

pending


Eligibility Criteria:
Inclusion Criteria:

* Written informed consent from the patient or legally acceptable representative
* Males and females
* Diagnose as hypertensive intracerebral hemorrhage
* Onset of symptoms within 6\~48 hours
* Position of bleeding major in basal ganglia
* The sum of scores on items 5 and 6 on the NIHSS were \>= 2 at baseline and the total score (items 1-11) was \>=6 and \<=20
* Volume of Hematoma \<= 30 ml
* Premorbid mRS score of 0 or 1

Exclusion Criteria:

* Allergy to known study drugs or excipients
* Experienced stroke in latest 3 month
* Volume of Hematoma \> 5 ml in other bleeding position
* Obstructive hydrocephalus
* Any diagnosis as other than hypertensive ICH
* Unconsciousness
* Severe concurrent illness with life expectancy less than 90 days
* Pregnancy or breast-feeding
Effects of Modified Constraint-Induced on Chronic Stroke Patients

In the present study, it was aimed to compare the proprioception training applied in addition to conventional treatment and Modified Constraint-Induced Movement Therapy treatment in patients with chronic strokes and to investigate the effects on proprioception, spasticity, functional motor skills and daily living activities in the upper extremity.


Eligibility Criteria:
Inclusion Criteria:

* Post stroke hemiparetic patients of six months
* spasticity ≤ Grade -3 on modified Ashworth scale
* those patients capable of extension of at least 10º each at Metacarpophalangeal (MCP), Proximal Interphalangeal (PIP) and Distal Interphalangeal (DIP) joints and 20º at wrist joint
* a score of 24 or higher on the Modified Mini-Mental State Examination
* no excessive pain in the affected upper limb, as measured by a score of 4 or higher on a 10-point visual analog scale

Exclusion Criteria:

* Patients with history of previous stroke,
* angina,
* uncontrolled hypertension, on medication that could impair neuromuscular performance,
* wrist or finger pathologies, significant visual or hearing impairment,
* balance problems which may compromise safety during sound upper limb constraint,
* unwilling to participate
Role of Intralipid in Management of Organophosphorus Poisoning

Aim of the study:

To assess the role of intralipid emulsion in the acute man-agement of organophosphorus toxicity and its benefits in de-creasing mortality rates among victims.

Organophosphates (OPs) are cholinesterase inhibitors that are widely used as pesticides and organophosphate (OP) poisoning is an important public health concern in Egypt especially in the rural farming population. Organophosphate toxicity lead to a characteristic toxidrome that includes muscarinic, nicotinic and central nervous system signs and symptoms and, without proper and early antidotal treatment, death. A new antidote is the need of the hour. Lipid emulsion being inexpensive, easily available and effective in management of other lipid soluble toxins may be a novel option. The exact mechanisms by which ILE exert their beneficial effects are not fully understood, and several have suggested synergistic effects of several mechanisms. The mechanisms of action can be divided into intravascular, membrane, and intracellular effects. The original theory explaining the mechanism of lipid rescue was that of "lipid sink", suggesting sequestration of lipophilic compounds to an expanded intravascular lipid phase, extracting the offending agent from the target tissue, and reversing the toxicity. Other hypotheses relate to the mechanism by which ILEs facilitate cardiac rescue from drug poisoning. These include:

1. increasing myocardial energy substrate delivery and a direct cardiotonic effect of ILE on the poisoned heart.
2. an effect of ILE on calcium ion channels through high levels of long-chain fatty acids, leading to increased cardiomyocyte calcium and positive inotropic effect.

Eligibility Criteria:
Inclusion Criteria:

* Age group of 18-60 years who are exposed to organophosphorus compounds.
* Clinical manifestations of organophosphorus toxidromes (hyper-salivation, lacrimation, sweating, urinary incontinence, di-arrhea, vomiting and abdominal pain).

Exclusion Criteria:

1. Patient or relative in charge refusal.
2. Chronic renal or liver disease manifested by history, clinical and investigatory diagnosis.
3. Previous history of acute or chronic pancreatitis
4. Combined poisoning with non OP compounds
5. Asymptomatic patients.
6. Contraindications to intralipid emulsion as:

   * disturbances of normal fat metabolism such as patho-logic hyperlipemia manifested by history, clinical and investigatory diagnosis.
   * lipoid nephrosis manifested by history, clinical and investigatory diagnosis.
Rehabilitation After Admission in Intensive Care Unit for COVID-19

France and especially the region "Grand Est" have been severely impacted by the COVID-19 pandemic. The first affected patients gradually began leaving the hospitalization sector and some of them required rehabilitation before returning home.

Because it has only been studied for few months, COVID 19 possible impairment remain unknown, especially in patients who required admission in ICU and needed rehabilitation.

In order to better understand the impact of the disease, the investigators wish to carry out a descriptive analysis of hospitalized patient in rehabilitation center for Post-Covid-19 rehabilitation after ICU.

The purpose of this study was to describe the impairments and functional independency in patients addressed to a rehabilitation center after an ICU stay for COVID 19 and to explore the factors associated with their evolution.


Eligibility Criteria:
Inclusion Criteria:

* Post-COVID patient hospitalized in rehabilitation center
* Admission in Intensive Care Unit with proven COVID-19 disease before

Exclusion Criteria:

* Patients not willing to participate via using their medical files
Changes in Volumetric Hemodynamic Parameters Induced by Fluid Removal on Hemodialysis

Changes in volumetric hemodynamic parameters and fluid overload (Cardiac Index,Stroke Volume, Thoracic Fluid Content, Systemic Vascular Resistance) were measured using a impedance cardiography (ICG) (CardioScreen 1000 - Haemodynamic Measurement System, Medis. GmbH Ilmenau) beginning 15 min prior to midweek dialysis session and continuous measurement thereafter, with a 15-min period after the termination of hemodialysis. Fluid overload were measured by BCM Monitor Fresenius before hemodialysis.


Eligibility Criteria:
Inclusion Criteria:

* give voluntary consent to participate in the study
* patients on maintenance hemodialysis at least 3 months
* stable dry weight
* single-pool Kt/V \>1.4
* no clinical cardiovascular disease during the 6 months preceding entry

Exclusion Criteria:

* not meet the above criteria
* episode of illness (for example: infection)
* pregnancy
AI Performance for the Detection of Bone Fractures in Children

The artificial intelligence (AI) software BoneView (GLEAMER Company, Paris, France) has been designed, tested and validated to detect and locate recent or semi-recent fractures on standard radiographs.

The objective will be to assess the AI performance for the detection of bone fractures in children aged less than 2 years old in suspected child abuse setting.

These patients benefit from a whole body radiography with a double blind reading by a "generalist" radiologist and a radiologist with expertise in child abuse. This readings will be compared with the AI results.

Hypothesis is that AI is effective for child fractures detection and could be of help especially for radiologists who are not experts in child abuse.


Eligibility Criteria:
Inclusion criteria:

* aged less than 2 years old
* whole body radiography performed for suspected child abuse setting
* report available with a double blind reading (generalist radiologist and radiologist with expertise in child abuse)

Exclusion criteria:

* Radiograph not interpretable ( poor quality)
* AI not applicable
A Study Assessing Iron Status and Anemia in Filipino School Children From MIMAROPA Region

The purpose of this study is to assess the iron status and to confirm the usability of the non-invasive ZnPP measurement for screening the different stages of iron deficiency defined by standard measurements from blood.

Brief description: The purpose of this study is to assess the iron status and to confirm the usability of the non-invasive ZnPP measurement for screening the different stages of iron deficiency defined by standard measurements from blood.

Detailed Description:

The primary objective of this study is to assess the iron status and the prevalence of the different stages of iron deficiency measured and defined by the standard blood iron measurements and by the non-invasive measurement of red blood cell Zinc Protoporphyrin fluorescence in the microcirculation of the lower lip.

The secondary objective is to compare and to assess the usability of the non-invasive ZnPP measurement versus other standard iron status measurements from blood in distinguishing the different stages of iron deficiency.

Subjects will be enrolled into the study after signing an assent form in addition to having parental informed consent signed. Total study duration is 1 day.

Eligibility Criteria:
Inclusion Criteria:

1. Age between 6 - 11 years old
2. Having obtained his/her informed assent.
3. Informed consent signed by one parent or legal authorized representative if applicable.

Exclusion Criteria:

1. Subjects or subjects' parent(s) or legal representative who are not willing and not able to comply with scheduled visits and the requirements of the study protocol
2. Currently participating or having participated in another clinical trial within 4 weeks prior to trial start.
3. Any disease of the lip and mouth that does not allow performing the lip measurement.
4. Diagnosis of any blood disorders affecting red blood cells ( aplastic anemia, autoimmune hemolytic anemia, thalassemia)
5. Diagnosis of any blood disorders affecting white blood cells (lymphoma, multiple myeloma, myeloplastic syndrome)
6. Diagnosis of any blood disorders affecting platelets ( idiopathic thrombocytopenic purpura, primary thrombocythemia)
7. Diagnosis of blood plasma ( hemophilia, von Willebrand disease)
8. Diagnosis of acute or chronic inflammatory disease (respiratory tract, digestive tract -bowel, liver, and any kidney disease)
9. Diagnosis of any neoplastic disease