cyrilzakka/clinical-trials huggingface dataset:
Graded Motor Imagery and Fall Risk in Older Adults

To determine if there is any carry over effect of sensation training for the feet, officially called Graded Motor Imagery (GMI), will impact balance and fall risk factors in older individuals. This will be looked at to see if there is a difference in balance and sensation before and right after the training.

In order to increase acuity of body maps, various tactile and movement-based strategies have been recommended and supported for research focusing on sensory discrimination. Current evidence, specific to painful conditions related to altered cortical mapping, have shown growing evidence in reducing pain and disability. In regards to it's ability to alter foot pain in older adults and decreasing fall risk, prior conference case study and case series presentations have suggested potential clinical benefit, but it has not been formally studied. The aim of this study is to determine if a sensory discrimination training for feet in older adults can alleviate pain, improve sensory discrimination, and also decrease fall risk. Specifically, does a 20 minute training session improve pain, balance (Brief-BEST test), and sensory discrimination in individuals over 65 years of age. Secondary analysis may exam characteristics that best identify those who benefit from this training.

Eligibility Criteria:
Inclusion Criteria:

* Be able to read and understand English
* Be over the age of 65
* Be independent with ambulation (with or without an assistive device)
* Not have any skin condition or injury to the plantar or dorsal part of the foot
* Have the visual ability to view images on a tablet to partake in a test

Exclusion Criteria:

* No existing skin conditions on the bottom of the foot that would impair sensation
* No current injury to the plantar or dorsal side of the foot
* No prior surgery or major injury to the plantar or dorsal side of the foot
* Lacking sensation in the foot
* Unable to read and understand English
* Lacking ability to view images on a tablet to partake in a test
* Unable to ambulate (with or without an assistive device)
Promise Women Project

The goal of this study is to develop and test an intervention program to improve cervical cancer prevention among Muslim American women. The main questions the investigators aim to answer are:

* Will the religiously tailored and culturally appropriate intervention program improve participants' knowledge and acceptance of cervical cancer prevention?
* Is the intervention program feasible to conduct and acceptable to participants?

Participants will be asked to:

* Attend focus group sessions to provide input on the development of educational materials.
* Complete pre- and post-intervention surveys to measure changes in knowledge and acceptance of cervical cancer prevention.
* Engage in the intervention program, which includes education and experiential practice/communication skills training.
* Provide feedback through satisfaction surveys. Researchers will compare participant outcomes before and after the intervention to assess its effectiveness. Additionally, the program's feasibility and acceptability will be evaluated based on enrollment rates, successful implementation, participant engagement, retention, and satisfaction.

This project involves creating special educational materials for Muslim women to learn about cervical cancer prevention. The investigators will engage in discussions with 10 Muslim women during dedicated group sessions to ensure the suitability of the materials. They will also seek input from Muslim religious leaders. Subsequently, they will conduct surveys before and after the program to assess the effectiveness of the materials in facilitating women's learning and comprehension of cervical cancer prevention. To determine its efficacy and acceptability, the investigators will implement the program with an additional 20 women and gather their feedback. The goal of this project is to promote the health and well-being of Muslim women by providing them with culturally and religiously sensitive information regarding cervical cancer prevention.

Eligibility Criteria:
Inclusion Criteria:

* Inclusion criteria:
* Female Muslim individuals above 18 years old.
* Able to speak and understand English.
* Have not had a hysterectomy.
* Have not had a cervical cancer diagnosis.
* Willing to participate in the educational program and undergo cervical cancer screening.
* Physically well, able to give consent form.

Exclusion Criteria:

* Under age 18
* Not Muslim
* Unable to provide consent
* Participated in a pilot study
Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study

The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups

Treatment groups that patients will be randomized to include 1) topical steroid plus oral antibiotic group, and topical minoxidil after 8 months 2) topical steroid plus intralesional steroid group and topical minoxidil after 8 months. Both these regimens are used as the first-line treatments by clinicians. The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups.

In this study, the investigators are looking to determine how standard treatment affects the outcome of central centrifugal cicatricial alopecia; to determine if topical steroid with With Doxycycline has better outcome than topical steroids with intralesional steroids in central centrifugal cicatricial alopecia, and to determine how the addition of topical minoxidil as a treatment changes the outcome of central centrifugal cicatricial alopecia.

Eligibility Criteria:
Inclusion Criteria:

* African-American women, ages 18-60 years old
* with a clinical diagnosis and biopsy-proven CCCA, with Central Scalp Alopecia Scale severity 1 through 4 will be included in this study
* These subjects will be seen and treated in Wake Forest Baptist Health Dermatology Outpatient Clinic

Exclusion Criteria:

* Patients with other forms of hair loss in addition to CCCA will be excluded
* Other patients to be excluded are those with other forms of inflammatory scalp disease (with the exception of mild seborrheic dermatitis)
* patients who have had topical treatment for CCCA within the past 4 months (including topical steroids, topical minoxidil, or any other topical hair regrowth medication)
* patients who have been on a long-term oral antibiotics for hair loss within the past year
* patients who have undergone more than two rounds of intralesional steroid injections to the scalp in the past one year.
Population PK of Antibiotics, Sedative and Analgesics, and Antiplatelet Drugs During ECMO

The purpose of this study is to optimize the dosage regimen of drugs in patients during during Extracorporeal Membrane Oxygenation (ECMO) by population pharmacokinetic modeling.


Eligibility Criteria:
Inclusion Criteria:

* Patients who are taking levofloxacin, meropenem, vancomycin, cefepime, midalzolam, dexmedetomidine, propofol, clopidogrel, ticagrelor, or prasugrel while underdoing Extracorporeal Membrane Oxygenation

Exclusion Criteria:

* Pregnant women
* Receiving a therapy that can affect blood concentration due to a drug-drug interaction with levofloxacin, meropenem, vancomycin, cefepime, midalzolam, dexmedetomidine, propofol, clopidogrel, ticagrelor, or prasugrel
Compensatory Sweating After Unilateral Sympathectomy on the Dominant Side or Bilateral Sequential Sympathectomy

The standard treatment for palmar hyperhidrosis is bilateral sequential thoracic sympathectomy. High rates of compensatory sweating due to the surgical procedure are described in the literature. In the search for a reduction in this side effect, it is possible that unilateral sympathectomy in the dominant side obtains acceptable results and leads to less compensatory sweating with improvement of the quality of life. The aim of this study it to compare the intensity of compensatory sweating due to the standard treatment, that is, bilateral sequential videothoracoscopic sympathectomy in relation to unilateral thoracic sympathectomy on the dominant side.


Eligibility Criteria:
Inclusion Criteria:

* Body mass index equal to or less than 28;
* Exclusive palmar hyperhidrosis or palmar hyperhidrosis associated with axillary and / or plantar hyperhidrosis;

Exclusion Criteria:

* Being sinister (or left-handed);
* Craneo-f acial or generalized hyperhidrosis;
* Coagulopathies;
* Previous thoracic surgery;
* Other comorbidities such as cardiological, metabolic, infectious or neoplastic diseases;
* Pregnancy;
Comparison of Vaginal Axis on MRI in Alternative Apical Prolapse Surgeries to Sacrocolpopexy

Sacrocolpopexy remains the preeminent modality in addressing apical prolapse surgically. Nevertheless, amplified morbidity rates within cohorts characterized by obesity and advanced age constrain the advantages conferred by the procedure. Recent years have witnessed a proliferation of inquiries appraising the efficacy of laparoscopic lateral suspension, pectopexy, and sacrospinous ligament fixation interventions, which have, over time, garnered extensive clinical application, in relation to recurrence rates. A multitude of investigations have been undertaken to delineate the optimal vaginal axis. In the present investigation, we have delineated a research protocol aimed at scrutinizing these alternative surgical modalities with regard to their impact on the vaginal axis.

The study objective pertains to the assessment of vaginal axis in patients undergoing apical prolapse surgery, whether they have undergone hysterectomy or not. The investigation is designed to test the null hypothesis by means of a comparative analysis of preoperative and postoperative Magnetic Resonance Imaging images capturing the vaginal axis. This examination will be conducted on patients slated to receive lateral mesh suspension, pectopexy, and sacrospinous ligament fixation procedures for the correction of apical prolapse.

Eligibility Criteria:
Inclusion Criteria:

* Female with genital prolapse

Exclusion Criteria:

* Patients who had pouch of Douglas obliteration
* Patients with enterocele
* Patients who have any congenital or acquired anatomic and reproductive anomaly
Association Between Attention Deficit Hyperactivity Disorder and Bulimia Nervosa in Outpatients With Eating Disorders

To understand whether a relationship exists between eating disorders and ADHD, we seek to clarify the prevalence of ADHD in individuals with eating disorders. To this end, we will estimate the prevalence of ADHD, and other neuropsychiatric disorders, in outpatients with history of an eating disorder diagnosis. Secondarily, we will identify patterns of cognitive deficits in outpatients with history of an eating disorder diagnosis. We will also examine whether ADHD in this population is associated with functional and familial correlates associated with ADHD.


Eligibility Criteria:
Inclusion Criteria:

* Male and female outpatients between, and including, 18 and 55 years of age with a history of eating disorder diagnosis.

Exclusion Criteria:

* Any clinically unstable psychiatric conditions such as: acute psychosis, acute panic, acute obsessive compulsive disorder, acute mania, acute suicidality, acute substance use disorders (alcohol or drugs), and sociopathy.
* Any metabolic, neurological, hepatic, renal, cardiovascular, hematological, opthalmic, or endocrine disease that would confound ability to participate in valid assessments.
* Mental retardation (IQ \<75).
* Organic brain disorders.
* Non-English speaking subjects will not be allowed into the study because the assessment instruments are unavailable and have not been adequately standardized in other languages.
ETOL-Elderly Study of the Efficiency of the Innovative Food Supplement in Elderly Adults

The aim of this pilot study is to conduct a study on geriatric population in Slovenia (non-users of dietary supplements/medicines with vitamine D, vitamin B12 and protein) and assess deficiency of selected nutrients, and to investigate the efficiency of the innovative food supplement prototype in improving nutritional status of elderly adults.

The main objective is to show that in the geriatric population regular use of investigation food supplement would improve nutritional status. The study should provide answers to the following main questions: (1) Is regular use of investigated product beneficial for improving serum vitamin D levels in elderly population? (2) Is regular use of investigated product beneficial for increasing daily protein intake in elderly population? (3) Is regular use of investigated product beneficial for improving vitamin B12 status in elderly population?

Eligibility Criteria:
Inclusion criteria:

* Subject Informed consent form (ICF) is singed
* Aged at least 65 at the time of the signature of ICF
* A body mass index lower than 32 kg/m2
* Willing to avoid a consumption supplementation with protein, vitamin D and vitamin B12 during the study
* Willing to follow all study procedures, including attending all site visits (including blood sampling) and keeping a diary for using the product and six 24-hour dietary records (3x pre-intervention, 3x during last week of the intervention)

Exclusion criteria:

* Medical treatment with Vitamin D and/or Vitamin B12
* Supplementation with protein, vitamin D and/or vitamin B12 during least 2 months
* Known drug and/or alcohol abuse
* Known lactose/gluten intolerances/food allergies
* Inadequate veins (in the opinion of the investigator) or known contraindication for venous blood withdrawal
* Have chronic bowel disease (ulcerative colitis, Chron's disease, stomach or duodenal ulcer, chronic inflammation of the stomach or duodenum)
* Have acute gastrointestinal infection with vomiting and / or diarrhea
* Have planned general anaesthesia or colonoscopy at the time of the study
* Have malabsorption syndrome
* Less than 5 years after treatment for gastrointestinal cancer (stomach, duodenum or colon)
* Have stomach or bowel resection
* Do not have neat and functional teeth
* Take regular or occasional laxative products
* Use antacids (Rupurut / Rutacid / Talcit)
* Mental incapacity that precludes adequate understanding or cooperation
* Participation in another investigational study
Exercise Program for Knee Recovery in Football Players with ACL Injuries

This study aims to evaluate the effectiveness of a structured exercise program in improving knee function, muscle strength, and range of motion in football players recovering from anterior cruciate ligament (ACL) injuries. The study seeks to answer whether a rehabilitation program can restore the performance of the injured leg to levels comparable to the uninjured leg and significantly improve knee functionality over time.

Anterior cruciate ligament (ACL) injuries are among the most common and challenging injuries faced by athletes, particularly football players. These injuries can significantly impact knee stability, muscle strength, and range of motion, making effective rehabilitation essential for a full recovery and return to sports.

This study investigates the impact of a structured exercise program on knee rehabilitation in male football players aged 18-22 years with ACL injuries. The goal is to understand whether this program can restore knee function and strength in the injured leg to levels comparable to the uninjured leg.

The rehabilitation program is designed to be implemented over 22 weeks, starting with five sessions per week and tapering to three sessions per week in the later stages. The program focuses on progressively strengthening the thigh and leg muscles, improving knee flexibility, and enhancing overall joint function.

The study uses a pre- and post-measurement experimental design with a single group of participants. The results will help determine whether structured exercise programs can effectively rehabilitate the knee after ACL injuries, enabling football players to regain performance and reduce the risk of future knee problems.

The findings will contribute valuable insights for sports medicine professionals, physiotherapists, and trainers in developing evidence-based rehabilitation protocols for athletes.

Eligibility Criteria:
Inclusion Criteria:

* Confirmed injury to the Anterior Cruciate Ligament (ACL).
* Currently active in playing football.

Exclusion Criteria:

* History of previous surgery to the knee.
* Presence of other musculoskeletal injuries.
* Diagnosis of chronic health conditions.
Impact of Telemonitoring in the Management of Complex IBD in Spain: M-TECCU

M-TECCU is a study: multicenter, randomized and open. It consists of two parallel groups to compare the efficacy of the TECCU web-based telemonitoring system to achieve and maintain activity remission in patients with moderate-high complexity inflammatory bowel disease compared to usual clinical practice.

Clinical trial with an open, randomized and controlled non-inferiority medical device, in which the impact of a follow-up method through a web telemonitoring platform on the time in clinical remission of patients with complex IBD is evaluated, in comparison with the usual follow-up in outpatient clinics.

Patients with complex IBD are considered to be those who receive treatment with immunosuppressants or biological therapies to control the luminal activity of their disease. Patients carry out periodic controls for the disease according to a pre-established schedule based on national and international clinical guidelines. The patients in the telemonitoring group (G_TECCU) follow these controls through the TECCU platform, a web system that allows them to fill in questionnaires related to the clinical variables under study and communicate freely with healthcare personnel during pre-established controls and when the patient deems it necessary. On the other hand, the patients of the control group (G_Control) carry out the controls according to the same schedule as G_TECCU, but following the usual clinical practice.

Eligibility Criteria:
Inclusion Criteria:

* Patients ≥18a
* IBD (CD or UC) diagnosed according to ECCO criteria
* Start treatment with immunosuppressants and/or biological therapies due to luminal activity
* signed informed consent

Exclusion Criteria:

* Pregnant women
* Presence of active perianal disease, ileoanal reservoir, or definitive stoma
* Patients with mental illness or other poorly controlled illness
* Patients with active cancer diagnosis
* Terminal patients and/or palliative care (SECPAL)
* Family members of the research team
* Patients without a telephone line to connect with a mobile, tablet and/or computer / Inability to drive
* Cognitive or linguistic difficulties
* Patients included in another experimental study
Pediatric Intensive Care and COVID-19

In this prospective longitudinal cohort the investigators reported the clinical, and biological characteristics of all critically ill patients admitted in the pediatric intensive care unit (PICU) of Bicêtre Hospital during the 2019 coronavirus disease (COVID-19) pandemics. Patients were older than 37 weeks of gestational age. No upper limit was set as the unit was transiently converted into a pediatric "adult COVID-19" intensive care unit.

All patients will be monitored during their PICU stay.

Clinical characteristics include: age, gender, co-morbidities, organ support therapies (mechanical ventilation, renal replacement therapy, extracorporeal membrane oxygenation, vasopressors), organ complications (pulmonary embolism, acute respiratory distress syndrome, renal failure, heart failure) and function, infective complications (ventilator associated pneumonia, central line associated bloodstream infection, pulmonary access, sepsis, septic shock), microbiologic and viral identification, 7-day and 28-day mortality.

Biological characteristics include:

* Admission workup: qualitative and quantitative Ig, ferritin, creatinine kinase, complement study (C3,C4,CH50),
* Daily workup: blood cells count, arterial blood gas analysis, lactate, electrolytes, albumin, blood urea nitrogen, creatinine, hemostasis (fibrinogen, factor V, II+VII, factor X, prothrombin time, antiXa activity, activated cephalin time, D-dimer), C-reactive protein, procalcitonin.
* Twice weekly workup: circulating cells phenotyping (T cell and subclass including Treg, B cell, Natural Killer cell, myeloid derived suppressor cell, neutrophils), interleukin 6.
* Bone marrow analysis when indicated by attending staff.

Eligibility Criteria:
Inclusion Criteria:

* Patients suspected or confirmed of severe acute respiratory syndrome Coronavirus 2 infection
* No opposition from patients or legal representatives after study information
* Patients admitted to the pediatric intensive care unit of Bicêtre Hospital, Assistance Publique Hôpitaux de Paris - Paris Saclay University
* Between March 15, 2020 to June 31, 2021

Exclusion Criteria:

* Patient or legal representative refusal to participate
Exploring the Mechanisms of Resistance of Stem Cells Myeloproliferative Opposite of Tyrosine Kinase Inhibitors in 3d Model Niche Endosteal

Myeloproliferative disorders (MPD) include chronic myeloid leukemia (CML) (Ph +) and essential thrombocythemia (ET), the polycythemia vera (PV), myelofibrosis (MF) called SMP Ph. CML is the ultimate model of carcinogenesis. SMP is a characterized by a malignant monoclonal proliferation of a pluripotent hematopoietic progenitor determined by the presence of a balanced translocation between chromosomes 9 and 22 (Ph chromosome) which leads to major changes of a large number of cell functions. Investigators now believe that within the bone marrow exist two types of "hematopoietic niches' niche osteoblastic / endosteal and vascular niche, controlling the maintenance and differentiation of hematopoietic stem cell pool. The endosteal niche, is a hypoxic region near the endosteal trabecular, which provides protection to deeply dormant stem cells. Data from the literature suggest that in the SMP, especially CML, the interaction of malignant stem cells with the microenvironment niche Endosteal could favor their survival and resistance to treatment. The therapeutic management of CML was upset by the use of tyrosine kinase inhibitors (TKIs). However, despite these advances, even in situations of undetectable residual disease, it has been observed relapses of the disease stopped TKI leaving suggest that there is a resistance of leukemic stem cell to TKI.

Work in the group Bipoa "Bio Engineering and Pathophysiology Osteo-Articular" helped develop a 3D model of ex vivo bone formation, which can mimic the endosteal niche. the goal is to apply this model to the SMP of hematopoiesis by referring to normal hematopoiesis. it will be tested the hypothesis that the endosteal ex vivo recess of the 3D modeling allows to highlight a special interaction can promote the persistence of the leukemia stem cell despite the use of effective therapies.


Eligibility Criteria:
Inclusion Criteria:

* Patients with LLC (chronic myeloid leukemia)