cyrilzakka/clinical-trials huggingface dataset:
Investigation of the Effectiveness of Regular Physical Activity in University Students

In our study, university students who coded the course from various faculties and departments within the scope of a university-wide free elective course, after regular physical activity; It was aimed to examine the effects on lifelong learning, physical activity, fatigue, sleepiness, depression, anxiety and stress levels, quality of life and walking distances and physiological expenditure indices.

Physical activity; They are body movements made using skeletal muscles in daily life and resulting in energy expenditure. In addition to daily living activities such as playing games, doing housework, walking, eating, and bathing, exercise and sports are also included in this definition. Physical activity is very important for a healthy life. Studies have reported that continuing physical activity, especially during growth and young adulthood, has positive effects on aerobic capacity, blood pressure, body composition, glucose metabolism, skeletal health and psychological health. Studies have reported that physical activity affects social and personal success in healthy adult individuals and is associated with sleep quality and depression. In this context, our work; After regular physical activity, university students who code the course from various faculties and departments within the scope of the university-wide free elective course; It was aimed to examine the effects on lifelong learning, physical activity, fatigue, sleepiness, depression, anxiety and stress levels, quality of life and walking distances and physiological expenditure indices.

Hypotheses of the study;

* Regular physical activity improves lifelong learning tendencies in university students.
* Regular physical activity increases the level of physical activity in university students.
* Regular physical activity reduces fatigue levels in university students.
* Regular physical activity reduces daytime sleepiness in university students.
* Regular physical activity improves depression, anxiety and stress levels in university students.
* Regular physical activity improves the quality of life in university students.
* Regular physical activity improves functional capacity and increases walking distance in university students.
* Regular physical activity reduces the physiological expenditure index in university students.

Eligibility Criteria:
Inclusion Criteria:

* Students who choose the course offered within the scope of university-wide elective courses
* No obstacle to aerobic exercise
* No chronic disease
* Individuals who have no history of surgery on the lower extremity in the last 6 months

Exclusion Criteria:

- Individuals who do not volunteer to participate in the study
A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

The purpose of this study is to evaluate change in geographic atrophy (GA) lesion growth of eyes treated with JNJ-81201887 compared to sham control.


Eligibility Criteria:
Inclusion Criteria:

* Have non-subfoveal (defined as not involving the center point of the fovea) geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with an area that can be measured and measures 2.5 millimeter square (mm\^2) to 17.5 mm\^2 (1- and 7- disc areas respectively), determined by the central reading center (CRC) from screening images of fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT)
* If GA is multifocal, at least one focal lesion must be greater than or equal to (\>=) 1.25 mm\^2 (0.5- disc area), as assessed by the CRC
* GA can be photographed in its entirety by FAF, using a 30- degree image centered on the fovea, as assessed by the CRC
* Fellow eye must be present with a best corrected distance visual acuity (BCVA) of counting fingers or better
* Man or woman (according to their reproductive organs and functions assigned by chromosomal complement)

Exclusion Criteria:

* History of transpupillary thermotherapy, photodynamic therapy or external-beam radiation therapy in the region of study eye
* Any prior thermal laser in the macular region, regardless of indication
* History of retinal detachment (with or without repair)
* Active, infectious conjunctivitis, keratitis, scleritis, or endophthalmitis
* Any sign of diabetic retinopathy or central serous chorioretinopathy
Study of Arimidex and Radiotherapy Sequencing

The purpose of this study is to compare TGF-β1 change in concomitant with that in sequential Arimidex in postmenopausal women with breast cancer, as measured by the proportion of patients with an elevation of TGF-β1 level at the 4th week after initiation of radiotherapy relative to the pre-treatment baseline.


Eligibility Criteria:
Inclusion Criteria:

* Provision of informed consent
* Pathological confirmation of breast cancer
* ER(+) and/or PR(+).
* Post-menopausal woman
* Age≤70 years old
* Breast conservative surgery with axillary dissection or staging by either sentinel nodes biopsy or axillary sampling
* Post-mastectomy patients with T1-T2 and N1-N3, or T3-T4 with any N Negative surgical margins
* Karnofsky≥70
* Laboratory criteria:

  * PLT≥100\*109/L
  * WBC≥4000/mm3
  * HGB≥10g/dl
  * ALT and AST\<2\*ULN
* No presence of metastatic disease
* No other malignant tumour

Exclusion Criteria:

* Presence of metastatic disease.
* T1, T2, N0 with mastectomy
* Non-infiltrative breast carcinoma underwent mastectomy
* Other malignant tumor (concurrent or previous).
* Positive surgical margins.
* Patients with demonstrated hypersensitivity to Arimidex or any excipient.
* Patients with severe renal impairment (creatinine clearance less than 20 ml/min).
* Patients with moderate or severe hepatic disease.
* Oestrogen-containing therapies should not be co-administered with Arimidex as they would negate its pharmacological action.
* Not able or willing to sign informed consent
* Autoimmune diseases including scleroderma, systemic lupus erythematosus and so on
Biological Markers for Post-Traumatic Stress Disorder

The current study aims to evaluate the sensitivity and specificity of a combination of various objective biomarkers for the diagnosis of PTSD.

PTSD affects a major fraction of military combatants and is also very common in the general population. Like other psychiatric conditions, the diagnosis of PTSD is currently based on an interview and questionnaires. However, the validity of these tools is limited since it depends on the evaluator's skills, and on patient compliance and mental status; and may be prone to exaggeration or minimization of symptoms. This prompts an urgent need for evaluation that will combine biomarkers for objective diagnosis, and follow up of individuals with PTSD.

Knowledge has grown in recent years regarding the biologic pathophysiological cascade responsible for the development of a "non-healing wound in the brain" that characterizes PTSD. Shortly after the traumatic experience, fundamental changes in autonomic nervous and endocrine activity are evident, together with changes in brain function; these can become chronic in those with long-standing unremitting PTSD. Several studies indicate good correlations of the diagnosis and severity of PTSD, with objective biological measures such as heart rate variability (HRV), brain connectivity and endocrine activity. However, the currently available data on these biological variables are still not sufficient to be used for diagnosis of PTSD.

The aim of the current study is to characterize the biological fingerprint of PTSD, by using a combination of biological measures, for an objective diagnosis.

Eligibility Criteria:
Inclusion Criteria:

1. The willingness and ability to read, understand and sign an informed consent form.
2. Age 20-60 years.
3. A history of more than 2 years of combat service, and of at least one potentially life-threatening combat experience.
4. One year or more after the last combat experience.

Exclusion Criteria:

1. Inability to attend scheduled clinic visits or comply with the study protocol
2. A history of traumatic brain injury or any other known brain pathology.
3. Substance use, except for prescribed cannabis, if it can be withheld for at least 24 hours prior to the study evaluation.
4. A current psychiatric disorder other than PTSD.
5. The inability to perform an awake brain MRI.
Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis

During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.


Eligibility Criteria:
Inclusion Criteria:

* Peritoneal dialysis patients

Exclusion Criteria:

* Insulin dependent diabetes mellitus
* AV-fistula, cardial arrhythmia persistence, or severe cardiac and lung disease
* Recent infectious disease
* Severe psychiatric disease
* Hypersensitivity to icodextrin
Diabetes and Psoriasis

Patients with psoriasis will be evaluated. The investigators will collect personal history, concomitant diseases and in particular the presence of type 2 diabetes mellitus, impaired fasting glucose and impaired glucose tollerance. The aim of the study will be to evaluate if there is a correlation among inflammation, insulin-resistance and psoriasis.


Eligibility Criteria:
Inclusion Criteria:

* patients with psoriasis

Exclusion Criteria:

* NA
Evaluation of the Effectiveness of the Use of a Carnitine-Orotate Complex and Biphenyl Dimethyl Dicarboxylate in the Pathogenetic Therapy of Metabolic-associated Fatty Liver Disease: a Prospective Cohort Study

The goal of this observational study is to learn the effectiveness and safety of the use of Carnitine-Orotate Complex and Biphenyl Dimethyl Dicarboxylate in the pathogenetic therapy of metabolic-associated fatty liver disease (MAFLD)


Eligibility Criteria:
Inclusion Criteria:

* Patients of both sexes aged 18 to 75 years, who are citizens of the Republic of Kazakhstan;
* Patients with a clinically and laboratory confirmed diagnosis of MAFLD, without severe concomitant diseases;
* Patients who do not receive other adjuvant therapy (metabolic therapy drugs, essential phospholipids, ursodeoxycholic acid, glycyrrhizic acid, ademetionine and others);
* Patients who have at least a 7-day gap between the end of other adjuvant therapy and the start of COC and BDD;
* Patients who voluntarily signed the informed consent form.

Exclusion Criteria:

* Patients who abuse alcohol according to the AUDIT-c questionnaire;
* Patients taking COC for more than 4 weeks before signing the informed consent;
* Patients with contraindications to COC;
* Patients diagnosed with diabetes mellitus;
* Pregnancy and lactation;
* Simultaneous use of levodopa, altretamine, cisplatin, statins;
* Patients with coinfection with HIV, HBV, HCV;
* Decompensated liver cirrhosis CPT≥7 points;
* GFR ≤ 15 ml/min/1.73 m2;
* Drug-induced liver damage;
* Taking narcotic and psychotropic drugs;
* Malignant formations of the liver and other organs (in history and currently) or a clinically significant increase in alpha-fetoprotein more than \>5 times;
* patients with pronounced biochemical activity (ALT, AST more than 10 ULN) and total bilirubin more than 2 ULN;
* Participation in an interventional clinical trial.
Everyday Activity Shoes: a Quantification of Impact Forces While Walking

This study aims to directly compare traditional everyday activity shoes (ASICS, Nike) with a shoe created to be flatter, less cushioned, and with less cradling of the foot (OESH shoe).

This study addresses a common question in popular media: what attributes of traditional everyday activity shoes (Nike, New Balance, etc.) make a shoe better or worse. There have been several peer-reviewed studies aimed to answer this by calculating forces and torques at the ankles, knees, and hips while subjects wore shoes with different properties. Such characteristics include heel size, cushioning and side-to-side cradling of the foot. Interestingly, most studies have shown that the lack of a heel, less cushioning, and less cradling of the foot actually improve the biomechanics related to forces and torques, thus decreasing wear and tear on the cartilage and bones of the leg. Wear and tear on cartilage and bone may predispose patients to a bone condition called "osteoarthritis", which is a disease where bones become damaged from rubbing on each other with breakdown of a cartilage "cushion". This study thus aims to directly compare traditional everyday activity shoes (ASICS, Nike) with a shoe created to be flatter, less cushioned, and with less cradling of the foot (OESH shoe).

Eligibility Criteria:
Inclusion Criteria:

* Women between the ages of 18-65
* Women who identify as "healthy"
* Women who run or walk for exercise more than three times per week
* Women in the Atlanta, Georgia area

Exclusion Criteria:

* Individuals with history of significant musculoskeletal pathology
* Individuals with musculoskeletal injury at time of testing
* Individuals unable to consent
* Individuals outside of the ages 18-65
* Individuals who are prisoners
* Individuals who do not speak or write in English
The Decisiveness of MFI-11 in Predicting Complications in Patients > 65 Years Who Underwent EBUS-TBNA Under Sedation

The aim is to evaluate the feasibility of MFI-11, one of the comprehensive frailty tests, before EBUS-TBNA. The secondary aim is to evaluate the usefulness of MFI-11 in predicting complications in risk assessment before EBUS-TBNA.

Patients who will receive anesthesia are directed to the anesthesia clinic for preoperative evaluation. The primary purpose of preoperative assessment is to reduce perioperative morbidity and increase quality, reduce the cost of perioperative care, and ensure that the patient recovers as quickly as possible. In this context, the American Society of Anesthesiology (ASA) score is a classification that includes medical comorbidities. The classification system alone does not predict perioperative risks, but when combined with other factors (e.g. type of surgery, frailty) it may help predict perioperative risks. Age is not among the criteria in the ASA.

In elderly patients, the indicator of decreased reserves and resulting weakness is called "frailty". Frailty is considered vulnerability and functional impairment caused by a significant decline in multiple systems. Objective, repeatable, and accepted scales must be used when evaluating frailty. MFI-11 is a strong predictor of mortality and postoperative complications.

Eligibility Criteria:
Inclusion Criteria:

* Patients who underwent EBUS-TBNA under sedation
* Patients aged \>65 years
* ASA 1-3 patients

Exclusion Criteria:

* Patients who did not volunteer for the study
* \< 65 years old patients
* ASA \> 3 patients
* Patients with psychiatric illness
* Intubated patients
* Patients with tracheostomy
* Patients with body mass index \> 30 kg/m2
* Patients with nasal and nasopharyngeal disease
* Patients with drug allergies (drugs used in anesthesia)
Uterine Manipulation During Minimally Invasive Surgery for Early Stage Endometrial Cancer

This is a prospective, multi-center, randomized non-inferiority phase III study to evaluate if patients undergoing a minimally invasive surgery for early stage uterine cancer have cancer cells in the fluid that is obtained at the time of their surgery when a uterine manipulator is placed versus patients who do not have a uterine manipulator placed.

In most cases, patients who have early stage endometrial cancer undergo a surgery to remove the uterus, cervix, tubes, ovaries, and occasionally lymph nodes. This is usually done through a minimally invasive (not a large incision) surgery. To accomplish this, the uterus needs to be manipulated (moved around) to help the surgeon complete your surgery. This is usually done with a device called a uterine manipulator and the majority of surgeons use this device in any patient undergoing a minimally invasive hysterectomy (removal of the uterus and cervix).

Even though the majority of surgeons use a manipulator, there are some surgeons who believe there is a possibility that cancer cells inside the uterus can be spilled into the abdomen through the fallopian tubes. This may cause a higher risk of spreading the cancer and or of the cancer coming back.

Currently, there are very limited research studies directly looking at whether the uterine manipulator may cause these cells to appear in the abdomen.

The purpose of this study is to see if patients undergoing a minimally invasive surgery for early stage uterine cancer have cancer cells in the fluid that is obtained at the time of their surgery when a uterine manipulator is placed versus patients who do not have a uterine manipulator placed.

A computer program will randomly assign the subjects to one of two groups. One group will have minimally invasive surgery with the use of a uterine manipulator and the other group will have minimally invasive surgery without the use of a uterine manipulator.

Researchers will use the information from this study to decide how best to take care of patients undergoing minimally invasive surgery for uterine cancer.

Eligibility Criteria:
Inclusion Criteria:

A subject will be considered eligible for inclusion in this study if all the following criteria are met:

1. Patient must be greater than or equal to 18 years old.
2. Suspected clinically early stage endometrial cancer of any histology (endometrioid, mixed, serous, clear-cell, carcinosarcomas, mucinous)
3. Pre-operative imaging not suggestive of extra-uterine disease, if obtained pre-operatively.
4. CA 125 testing is optional but, if obtained, must be within lab normal values. 5. ECOG performance status 0-2 (see appendix 1).

6. Signed informed consent and ability to comply with follow-up. 7. Per the opinion of the treating investigator, the patient must be a suitable candidate for the MIS surgical procedure.

Exclusion Criteria:

A subject must not have any of the following criteria:

1. Planned laparotomic hysterectomy
2. On progesterone therapy to treat their endometrial cancer
3. Any prior pelvic irradiation
Clinical Study to Determine the Optimal Operation Parameters During CO2 Removal With the Abylcap® System

This prospective study includes 5 patients with ARDS (Acute Respiratory Distress Syndrome) treated by mechanical ventilation. In case of respiratory acidosis, extracorporeal CO2 (carbon dioxide)removal might be necessary. We hereby work with the Abylcap system with the oxygenator Lilliput2 as CO2 remover (Bellco, Italy).

The patients (M/V) are older than 18, not pregnant, have a BMI\<30, and no contraindication for anticoagulation therapy.

Under standard conditions patients are treated with a blood flow of QB=300mL/min and a gas flow (100% 02) of QG=7L/min. Blood sampling is performed from the arterial bloodline in the patients at 0, 1h, 3h, 24h, 48h, 72h, 96h, and 120h.

A parameter study is also performed to optimise CO2 removal. Herewith, blood samples (1mL) are taken from the inlet and outlet line of the Lilliput2 at the previously mentioned time points and for different flow setting: Blood flow (QB) 200-300-400mL/min and gas flow (QG) 1.5, 3, 6, 7, 8L/min

Blood samples are analysed for the different blood gases from which the extraction in the CO2 remover can be calculated for each setting of QB (blood flow) and QG (gas flow).


Eligibility Criteria:
Inclusion Criteria:

* Patients with ARDS and respiratory acidosis on the intensive care unit
* Treated with the Abylcap system (Bellco, Italy)
* Not pregnant
Ozone Cardiovascular Effects in Genetically Susceptible People

Increases in air pollution are associated with increases in deaths from cardiovascular disease, but the investigators know little about how ozone air pollution affects the cardiovascular system. The investigators proposed study will determine the effects of ozone on blood vessel and heart function that could worsen illness in people with underlying heart disease. This will be accomplished by studying healthy volunteers who inhale ozone in a controlled clinical study, and also by studying their exposure to ozone and other pollutants during their normal daily activities. The investigators will study volunteers who may be at increased risk for the effects of ozone because of genetic susceptibility. Understanding the effects of ozone on the heart and circulation can help establish appropriate air pollution standards, and provide strategies to protect the most susceptible people.


Eligibility Criteria:
Inclusion Criteria:

* Healthy,
* Never-smokers with normal spirometry based on the standards published by Morris and co-workers (Morris et al. 1971), and
* A normal electrocardiogram. -

Exclusion Criteria:

* Any history of habitual smoking.
* Marijuana smoking within the past 5 years.
* Pregnancy.
* Any history of significant organ impairment, chronic respiratory disease, ischemic heart disease, active psychiatric disorder or current drug or alcohol abuse.
* Occupation involving regular, heavy dust or particle exposure, such as welding, mining, foundry work.
* FEV1 \< 75% of predicted at baseline screening.
* Subjects with atopy or allergic rhinitis will not be excluded as long as they do not require regular treatment with antihistamines or systemic steroids.
* Subjects on certain prescription medications such as prednisone or statins will be excluded. Use of other medications will be considered on an individual basis. Subjects will not be asked to discontinue prescription medications for the purposes of this study.
* Hypertension (blood pressure higher than 140/90 mmHg or on antihypertensive medication).
* Subject lives outside the Rochester metropolitan area.
Integrative Care and Acupuncture in MOHS Surgery

MOHS method is an effective surgical technique to remove skin cancerous tumors in the head-neck area. Patients undergoing MOHS surgery are struggled with emotional stress during the day of surgery, due to fear of significant damage to the body's image and anxiety about the need for repeated surgeries. In this study we will examine the effect of integrative medicine (including acupuncture, touch/manual, and breathing/relaxation modalities) on the reduction of anxiety and pain in patients undergoing MOHS surgery.

MOHS method is an effective surgical technique to remove skin cancerous tumors in the head-neck area, with immediate microscopic examination in a frozen slice of the full margin. Patients undergoing MOHS surgery are struggled with emotional stress during the day of surgery, due to fear of significant damage to the body's appearance and image and anxiety about the need for repeated surgeries performed on the same day to remove the tumor. In this study we will examine the effect of integrative medicine (including acupuncture, touch/manual, and breathing/relaxation modalities) on the reduction of anxiety and pain in patients undergoing MOHS surgery. The study was designed on the basis of interdisciplinary collaboration of researchers from plastic, integrative and gynecological medicine.

Eligibility Criteria:
Inclusion Criteria:

\* Patients referred to MOHS surgery

Exclusion Criteria:

* Pregnancy
* Hypertension treated with alpha and beta-blockers
* Chronic atrial fibrillation
* insulin dependent diabetes type 1
* Thyroid disease (hyperthyroidism)