cyrilzakka/clinical-trials huggingface dataset:
Identification of a Plasma Proteomic Signature for Lung Cancer

The primary objective is to identify a panel of plasma and/or serum proteins that differentiates the absence or presence of lung malignancy in samples obtained from subjects enrolled in this IRB/EC approved study with pulmonary nodules.

Blood samples are obtained from those patients undergoing procedures to determine if a lung nodule is benign or cancerous. The data from the study will not be used to guide or influence the treatment of the patients enrolled in this study. There is no change from the normal standard of care that patients receive.

Eligibility Criteria:
Inclusion Criteria:

* age ≥ 40
* any smoking status, e.g. current, former, or never
* co-morbid conditions, e.g. COPD
* Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity
* Pathology: malignant - adenocarcinoma, squamous, or large cell
* Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma)
* Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B)
* Clinical stage, Regional lymph nodes: N0 or N1 only
* Clinical stage, Distant metastasis: M0 only

Exclusion Criteria:

* prior malignancy within 5 years of lung nodule diagnosis
* No nodule size available
* No pathology data available for those with
* Current diagnosis of non-small cell lung cancer
* Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1
Multicentric European Study In Patients With Vertebral Metastases

Train-METASTRA is a retrospective study that will be performed in order to collect a large and harmonised amount of clinical and imaging data concerning vertebral metastases, focusing in particular on the risk of fractures. This type of dataset will be created from the medical records of 2000 patients admitted in the last ten years in the four European clinical centers participating in METASTRA project: "COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS", funded by the European Union under the call "HORIZON-HLTH-2022-TOOL-12-two-stage/Computational models for new patient stratification strategies". The project is coordinated by the University of Bologna (UNIBO) (PI prof. Luca Cristofolini) and involves 15 European partners, including Sarl Voisin Consulting Life Sciences VCLS, University of Szeged (Hungary), University of Sheffield (UK) and FrontEndART (Hungary).

This type of dataset is not currently available in the literature and it will be pivotal to the development of the METASTRA computational models for the stratification of the risk of fracture of patients affected by spinal metastases.


Eligibility Criteria:
Inclusion Criteria:

* Alive or dead
* Age 18 -99 years old
* Both male and female
* Diagnosis of cancer metastases at the spine
* Any SINS score
* Admitted for hospitalisation or outpatient visit from Jan 2012 to Dec 2022 N ≥ 1 non-stabilised metastatic vertebra
* Presence of baseline CT scan, and/or MRI and x-rays, showing the presence of metastatic lesions that are not surgically treated
* At least one follow-up visit at ≥ 3 months after the first evaluation or treatment

Exclusion Criteria:

* Minor patients
* Patients with diagnosis of primary spine tumour, degenerative spinal diseases, deformity or trauma
* Patients without non-stabilised vertebral metastases
* Patients without baseline CT scan or MRI
* Patients without follow up visits
BILACO Trial: Biliary Atresia - a Severe Complex Congenital Liver Disease

Biliary atresia is the most severe form of cholestatic liver disease. The children have high morbidity and mortality and get devastating pruritus and fatigue, failure to thrive, progressive hepatic failure and impaired neurodevelopment. The etiology is mostly unknown. More than half need a new liver from a living or deceased donor during childhood. However, correct timing of the transplantation is extremely difficult because of lack of consensus based on clinical assessment tools. All though the incidence is low, the cost of this disease is tremendous from both a clinical and human perspective. So far, protocolized neurodevelopment tests, genetic profiling, precise malnutrition evaluation based on clinical appearance, biochemical markers and brain MRI-scans, body composition, immunological function, level of physical activity and optimal time of transplantation in cholestatic children are unknown.

The aim is to determine risk factors for neurocognitive impairment in children suffering from severe cholestasis in order to determine optimal time for liver transplantation from a brain perspective.

In a prospective study, the investigators will investigate risk factors related to brain-, heart-, gut- and immunological function in the Danish cohort. This cohort consists of 75 children aged 0-18 years. In addition, 30 aged and gender matched healthy and 20 tetra fallot children will serve as control groups. The children will undergo extensive and advanced liver function evaluation, genetic profiling, nutrition and immunological status, neuro-imaging and neurocognitive evaluation at time of diagnose, 2 years of age, pre-school, pre-teenage, and teenage. In case of a liver transplantation, additional neuro-cognitive tests will be performed


Eligibility Criteria:
Inclusion Criteria:

* Biliary atresia
* Tetralogy of Fallot
* Healthy controls

Exclusion Criteria:

- Not able to participate in exams
Rheos® Diastolic Heart Failure Trial

The CVRx® Rheos® Diastolic Heart Failure Trial is a prospective, randomized, double blind trial with up to 60 subjects conducted at up to five centers in Europe. All subjects will be followed up to one year post implant.


Eligibility Criteria:
Inclusion Criteria:

* Be at least 21 years of age.
* Have bilateral carotid bifurcations that are below the level of the mandible.
* Have a left ventricular ejection fraction ≥ 45%.
* Clinical Heart Failure with elevated BNP or NT-Pro-BNP.

Exclusion Criteria:

* History of or suspected baroreflex failure or autonomic neuropathy.
* History of symptomatic bradyarrhythmias, pericardial constriction, infiltrative cardiomyopathy, cardiac valvular disease.
* Organ or hematologic transplant.
* History of prior surgery, radiation, or stent placement in carotid sinus region.
* History of severe chronic kidney disease.
* Life expectancy to less than one year.
Myometrial Biopsy for the Detection of Infection

This study is designed to demonstrate that women in labor become infected without exhibiting any clinical signs or symptoms of infection.

The infection is a dynamic process probably beginning shortly after the onset of labor. This process continues and is enhanced during active uterine contractions, which result in bacteria from the vagina being drawn up into the uterine cavity. During labor, bacterial colonization of the amniotic fluid, the decidua, and even the fetus can occur, resulting in infection of the mother and the fetus.

Eligibility Criteria:
Inclusion Criteria:

1. Patients must be afebrile throughout labor.
2. Amniotic fluid must be not purulent; presence of meconium is not an exclusion.
3. Patients undergoing an elective cesarean section.
4. Patients who have labored with intact or ruptured amniotic membranes.

Exclusion Criteria:

1. Patient with a temperature of ≥ 100.4o F.
2. White blood cell count ≥ 24,000.
3. Suspicion of chorioamnionitis.
4. Suspicion of a urinary tract infection.
5. Presence of diarrhea (defined \> 4 liquid stools in a 24 hour period).
6. Patient currently taking therapeutic antibiotics.
Acute Changes in Intraocular Cytokines After Intravitreal Bevacizumab

Purpose: To evaluate the acute changes in intraocular cytokines after intravitreal bevacizumab (IVB) in proliferative diabetic retinopathy.

Design: Prospective, open-label, controlled, randomized interventional clinical trial.

Participants: Twenty eyes of 28 consecutive patients who are scheduled for pars plana vitrectomy (ppV) for proliferative diabetic retinopathy were prospectively enrolled.

Methods: All patients were randomly assigned to receive IVB either at 2 or 7 days before ppV. Aqueous humor samples were taken from anterior chamber just before IVB and at the time of surgery. Multiplex cytokine array were used to assay various cytokines


Eligibility Criteria:
Inclusion Criteria:

* Patients with proliferative diabetic retinopathy who were scheduled for PPV for vitreous hemorrhage or tractional retinal detachment (TRD)

Exclusion Criteria:

* Eyes with any pharmacologic intervention on study eye within 6 months
* Eyes with panretinal photocoagulation on study eye within 3 months
* Eyes with any pharmacologic intervention on fellow eye within 3 months,
* History of ocular diseases other than diabetic retinopathy
* History of PPV on study eye
* History of systemic thromboembolic events including myocardial infarction and cerebrovascular accidents.
HLA Analysis in Autoimmune Encephalitis and Related Disorders: Part II

Autoimmune encephalitis (AE) are characterized by subacute onset of memory deficits, altered mental status or psychiatric symptoms, frequently associated with seizures, inflammatory cerebrospinal fluid and in cases with prominent limbic involvement, typical magnetic resonance imaging. Several autoantibodies (Abs) may be detected in AE, although its detection is not mandatory to establish a diagnosis. These Abs mainly recognize different synaptic and cell-surface proteins in the central nervous system, and are thought to be pathogenic as they alter the normal location or function of its antigens. Paraneoplastic neurological syndromes (PNS) are immune-mediated, remote complications of cancer. The clinical presentation is highly diverse, from central nervous system disorders (limbic encephalitis, cerebellar ataxia) to peripheral neuropathies and neuromuscular junction diseases. Two different kinds of Abs are associated with PNS: a first group known as onconeural Abs, which recognize intracellular antigens and are thought not to be pathogenic; and a second one whose targeted synaptic and cell-surface antigens shared with some non-paraneoplastic AE.

The primary trigger of the immune response is unknown for most of AE. In addition to acquired susceptibility such as herpes simplex encephalitis, genetic predisposition may also be important in the pathogenesis of AE. Human leukocyte antigen (HLA) is the genetic factor most frequently associated with autoimmune diseases, due to its genetic complexity and key role in the adaptive immune response. Others and we already described the HLA haplotypes associated with three types different of AE: anti-leucine-rich glioma inactivated 1 (LGI1), anti-contactin-associated protein-like 2 (CASPR2), and anti-glutamic acid decarboxylase (GAD). Nevertheless, the genetic predisposition of many other AE has not been investigated yet.

Cancer is considered as the trigger of the immune response that lead to PNS development, as the neural antigens recognized by the onconeural Abs are also expressed by tumor cells. Nevertheless, it is still unknown why some patients develop PNS and others do not, even if they present the same histological type of tumor, suggesting that some particular, maybe genetic, characteristics of the patients may play a role in this susceptibility. Furthermore, there is already evidence that, for those neurological diseases that may appear either as PNS or as non-paraneoplastic autoimmune disorder (i.e. Lambert-Eaton myasthenic syndrome), HLA profiles are not the same.


Eligibility Criteria:
Inclusion Criteria:

* Presence of well-characterized antibodies in serum or cerebrospinal fluid;
* Clinical picture compatible with the detected antibody based on the literature;
* For PNS, cancer detected and compatible with the detected antibody based on the literature

Exclusion Criteria:

* Absence of complete clinicobiological data.
* Incongruences between antibody-clinics or antibody-cancer
Optimizing of Waiting - Time in the Anesthesia Admissions Ambulance of the Charité - University Medicine Berlin by Support of a Mobile Application - a Pilot Study

In this study the investigators measure and optimize the patients waiting time in the preanesthetic assessment by integrating an interactive mobile device. The aim of this study is to observe whether the patients mean waiting-time is reduced by the use of a special mobile application (Anaest-App) and, as a result , raises patient-satisfaction.

3000 patients as well as medical doctors receive tablet-devices. The Software (App) installed on these devices coordinates the virtual waiting numbers assigned to each patient-tablet. The medical doctor can virtually call up the next patient in line for preanesthesiologic assessment. After the examination both medical doctors and patients complete a brief questionaire regarding educational level, usability and overall satisfaction

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients of all ages
* Elective surgical procedure

Exclusion Criteria:

* Language inabilities (German)
* Severe hearing - loss and visual impairment
* In-Patient care \> 24 h
Investigation of the Effect of Food on the Bioavailability of a 25 mg Empagliflozin Tablet as Well as Assessment of Dose Proportionality Between 10 mg and 25 mg Empagliflozin Tablets Under Fasting Conditions.

Investigation of food effect on the bioavailability of a 25 mg empagliflozin tablet and assessment of dose proportionality between 10 mg and 25 mg empagliflozin tablets under fasting conditions.


Eligibility Criteria:
Inclusion criteria:

1. Healthy male and female subjects

Exclusion criteria:

1. Any relevant deviation from healthy conditions
Value of Target-controlled Intravenous Anaesthesia (TCIVA) in Spinal Cord Stimulation

Study design 60 patients Monocenter prospective study Randomized in 2 groups 36 months Objectives Demonstrate the superiority of target controlled intravenous anesthesia versus total anesthesia with the low back paresthesia mapping in at least 95% of patients implanted with a multicolumn lead.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years and ≤ 80 years
* FBSS
* Radicular leg et lumbar pain
* For more than 3 months after one or many spine surgeries
* Mixt pain (radicular leg et lumbar) with Neuropathic status
* Failure of conservative treatment
* Severe uni or bilateral radicular pain \> 5 / 10

Exclusion Criteria:

* Age \<18 years and\> 80 years.
* BMI \> 30 kg/m2.
* Back pain that can be treated by surgery (discogenic, vertebral instability, ...)
* Contraindication to TCIVA anesthesia under propofol remifentanil
* Psychiatric status
* Cancer
* No signature of informed consent.
* Women of childbearing without contraception
Autonomous Artificial Intelligence Versus AI Assisted Human Optical Diagnosis

Computer-aided image-enhanced endoscopy can predict the nature of colorectal polyps with over 90% accuracy. This technology uses artificial intelligence (AI) to analyze video recordings of polyps, learning to make diagnoses in real-time. This means that doctors can get immediate predictions about small polyps during the procedure, reducing the need for separate pathology exams and saving costs, ultimately improving patient care.

Human and AI interactions are complex and a framework to reap synergistic effects CADx systems when used by humans to harness optimal performance needs to be established. AI solutions in medicine are usually developed to be used as assistive devices, however, then they rely on humans to correct AI errors. Optical polyp diagnosis is a complex task. Non experts usually achieve diagnostic accuracy in 70-80%. CADx systems have a similar diagnostic accuracy when used autonomously. Clinical evaluation of CADx systems showed that CADx assisted OD performs equally to the operator performance when using non CADx assisted OD. To harness a benefit of clinical CADx implementation we would have to find a way that synergies between human and CADx come into play to eliminate cases in which CADx assisted and/ or human OD results in low diagnostic accuracy and also addresses the problem of serrated polyp recognition.

Our study hypothesis is that for CADx implementation, instead of using the high/low confidence framework, identifying cases with suboptimal diagnostic accuracy could be facilitated through identifying cases in which CADx and endoscopist disagreed in their diagnosis. Eliminating such cases might separate out cases with low accuracy when using CADx assisted OD. Since endoscopists have a high sensitivity but low specificity for serrated polyp OD, this framework will also allow us to implement a strategy to adequately manage serrated polyps found in the cohort.

Eligibility Criteria:
Inclusion Criteria:

* Indication for full colonoscopy.

Exclusion Criteria:

* Known inflammatory bowel disease
* Active colitis
* coagulopathy
* familial polyposis syndrome
* poor general health, defined as an American Society of Anesthesiologists class \>3
* emergency colonoscopy
Dosing Iodinated Contrast Media According to Lean vs. Total Body Weight

The purpose of this study is to evaluate the effect of dosing iodinated contrast media according to a patient's total body weight vs. lean body weight. Participants will be randomized into 2 groups based on contrast dosing technique, and solid organ enhancement at uniphasic abdominal CT will be measured.


Eligibility Criteria:
Inclusion Criteria:

* outpatients only
* patients scanned on modern Siemens scanners at our institution

Exclusion Criteria:

* self-reported history of chronic kidney, heart or liver disease
* allergy to iodinated contrast
* acute illness
* outside maximum threshold limit for weight-based contrast dosing
* pregnancy
* image degradation
Feasibility and Efficacy of Remotely Monitored Home-based Listening to Preferred Music for Pain in Older Adults With Low Back Pain

The purpose of this study is to examine the feasibility and acceptability of listening to 20 minutes of preferred style of music twice-daily for 4 consecutive days on pain among 20 community-dwelling older adults with lower back pain (LBP)


Eligibility Criteria:
Inclusion Criteria:

* self-report of Lower back pain (LBP)
* LBP in the past 3 months with an average rating of at least 30 on a 0 - 100 NRS for pain
* intact cognition
* no plans to change their pain medication regimens during the study time
* can read and understand English
* can travel to the study center
* agree to sign an informed consent

Exclusion Criteria:

* deaf or have severe hearing loss
* pregnant or lactating
* have an implantable pain-reducing device
* history of hospitalization within the preceding year for psychiatric illness
* diagnosis of Raynaud's disease
* have a functional limitation that requires the use of an ambulatory aid such as a cane, walker, or wheelchair
* history of brain surgery, brain tumor, or stroke
* severe depression (PROMIS Depression T-score ≥ 70) (Kroenke et al., 2020)
* severe anxiety (PROMIS Anxiety ≥ 70) (American Psychiatric Association, 2013)
* Mini-Mental State Examination score less than 24 (Creavin, Wisniewski, Noel-Storr, et al., 2016)
Evaluation of Root Parallelism in Cases of Anterior Teeth Spacing Clear Aligner Versus Fixed Appliances

evaluate root parallelism in cases of anterior teeth spacing treated with clear aligner versus fixed orthodontic appliances


Eligibility Criteria:
Inclusion Criteria: 1. Patients with anterior spacing as less than 2mm for anterior 2. Age range from 14 to 22 years old with no sex discrimination. 3. Good oral hygiene. 4. Presence of all permanent teeth not including third molars. 5. Provide informed consent and willingness to cooperate with study protocol.

Exclusion Criteria:

1. Medical problems or craniofacial disorders known to affect bone remodeling.
2. Congenital defect or deformed anterior teeth.
3. Presence of chronic or acute periodontal disease.
4. Radiographic evidence of bone loss.
5. History of systemic disease.
6. Previous orthodontic treatment.
Acceptability of Women to Intimate Partner Violence and Its Correlates Among Attendants of Maternal and Child Center in Assiut

identify acceptability of ever married women against intimate partner violence and its correlates among women attending primary health care in Assiut city.

Violence against women is a major public health problem . World Health Organization estimates that globally 30% of women have been subjected to either physical and/or sexual intimate partner violence(IPV) or non-partner sexual violence in their lifetime.

IPV refers to any behaviour within an intimate relationship that causes physical, psychological or sexual harm to those in the relationship. IPV definition covers violence by both current and former spouses and partners. Forms of intimate partner violence include: Acts of physical violence, sexual violence, emotional (psychological) abuse, and controlling behaviors.

Initial studies on IPV against women tended to concentrate on assessment of incidence and prevalence. Although prevalence is critical, reducing or eliminating some problems also requires comprehension of cultural norms and expectations.

An ecological approach showed that public attitudes accepting or justifying violence and aggression are a risk factor at a macro social level, as they can encourage or deter its occurrence in societies.

UN Women reported that among Egyptian women in reproductive age, the prevalence of lifetime physical and/or sexual intimate partner violence was 26% and the prevalence of physical and/or sexual intimate partner violence in the last 12 months was 14 %.

The Egyptian studies that assessed attitudes of acceptability of IPV and their predictors has explored acceptability to only one form of IPV. Using a single-item measures, they measured justification for the husband's use of more severe physical force in response to the wife's violation of expected domestic roles or his patriarchal control in marriage.

Eligibility Criteria:
Inclusion Criteria:

* Ever married women (current married women and who were married since one year) who seek health services at MCH center.

Exclusion Criteria:

* single women not previously married
* and women who were married since more than one year