cyrilzakka/clinical-trials huggingface dataset:
Ulcer Monitoring in Diabetes Mellitus

Telemedicine technology enables a direct and online text- and image communication in the treatment system from patient to the ulcer specialist. The technology is expected to have patient-related, economic and therapeutic benefits. The study is a substudy of a larger project entitled "Renewing Health", where also the economic and management aspects are highlighted. However, only few randomized prospective studies are conducted in this field. The purpose of the study is in a randomized prospective study, to assess the impact of the introduction of the telemedicine technology as consultation form between ulcer-nurses in the primary sector and the wound clinics at the hospitals in the region. It is assessed whether the technology can be adopted without incurring the patient a risk. The study aims to perform an impact analysis of the introduction of new technologies for telemedicine wound monitoring in the treatment of diabetic foot ulcers through different studies.

Through randomized and prospective studies the project will show whether a telemedicine approach to wound care can be used as an alternative to traditional attendance at a wound clinic and document whether this consultation form provides a greater patient-satisfaction and cost savings. The project will document that telemedicine is equivalent to conventional outpatient attendance from a therapeutic aspect in terms of number of hospitalizations, number of extra controls, acute interventions and wound healing.

The project is also investigating the extent of time spent on the personnel side using telemedicine consultations compared with conventional outpatient appearances.

Eligibility Criteria:
Inclusion Criteria:

* Having diabetic foot ulcer
* Referred for out-patient clinic treatment by general practitioner
* Referred for out-patient clinic treatment by a surgical department
* Living in Region of Southern Denmark

Exclusion Criteria:

* Psychiatric disorder
* Dementia
* Chronic alcohol abuse which can affect compliance
* Other disorder then diabetes mellitus that have caused foot ulcer (rheumatoid arthritis or arthritis urica)
* Serious kidney disease which requires dialysis
* Previous foot ulcer - which was part of the study
* Expected healing within 2-4 weeks where only one control (final) is expected
South Miami Hospital Fibroid Registry

The purpose of the Fibroid Registry is to provide a comprehensive database that captures patient characteristics, clinical outcomes and pot-treatment quality of life measures for patients treated for uterine fibroids. This database will serve as a platform for future comparative effectiveness and other health services research studies.

The proposed research will be a prospective registry study of patients treated for uterine fibroids at the Fibroid Center located at South Miami Hospitals Center for Women and Infants.

Our objective is to establish the Fibroid Registry:

* To collect and review short, middle and long term clinical outcomes data that will help inform and facilitate the decision making process of clinicians and patients on the safest and most effective treatment for symptomatic uterine myomas, leiomyomas, or fibromas.
* To be able to critically evaluate the quality of procedures being performed and to ultimately establish a gold standard of care based upon patient and clinical outcomes and characteristics.
* To ultimately establish a gold standard of care based upon clinical outcomes and patient characteristics.

Eligibility Criteria:
Inclusion Criteria:

1. Patients seeking treatment for uterine myomas, leiomyomas, or fibromas.
2. Patients between the ages of 18-89.
3. Patients that agree to participate and sign consent.

Exclusion Criteria:

1)Patients that decline to participate and/or are younger than 18 or older than 89.
Effect Of Instrumented Assisted Soft Tissue Mobilization On Pain, Function And Proprioception In Patients With Shoulder Impingement Syndrome

this study will be conducted to investigate instrumented Assisted Soft Tissue Mobilization On Pain, Function And Proprioception In Patients With Shoulder Impingement Syndrome

Shoulder impingement is a clinical syndrome in which soft tissues become painfully entrapped in the area of the shoulder joint. Patients present with pain on elevating the arm or when lying on the affected side. Shoulder pain is the third most common musculoskeletal complaint in orthopedic practice, and impingement syndrome is one of the more common underlying diagnoses. On the pathophysiological level, it can have various functional, degenerative, and mechanical causes. The impingement hypothesis assumes a pathophysiological mechanism in which different structures of the shoulder joint come into mechanical conflict. The decision to treat conservatively or surgically is generally made on the basis of the duration and severity of pain, the degree of functional disturbance, and the extent of structural damage. The goal of treatment is to restore pain-free and powerful movement of the shoulder joint.Instrument-assisted soft tissue mobilization (IASTM) is a popular treatment for myofascial restriction which is applied using specially designed instruments to provide a mobilizing effect to soft tissue (e.g., scar tissue and myofascial adhesion) to decrease pain and improve range of motion (ROM) and function. eighty patients will be allocated randomly into two equal groups; the experimental one will receive IASTM and the control will receive traditional therapy for eight weeks.

Eligibility Criteria:
Inclusion Criteria:

* Patients with impingement syndrome from both genders.
* Age range from 25-40 years
* Body mass index 18.5-24.9 kg/m2
* Subjects are non-smokers.
* Shoulder impingement symptoms lasting at least 6 weeks

Exclusion Criteria:

1. Hand truma, present pain or other kinds of complaints in the hand area.
2. History of deformities, fractures, or surgery of the tested upper extremity joints affecting hand grip strength within the last 6 months.
3. Presence of cardiopulmonary, hormonal disorder, central or peripheral neurological deficits or any condition that can influence the results.
Easy Peasy: Health Effects of Supplementation With Vegetables

The proposed study aims to test the effects of supplementing healthy individuals (with low baseline vegetable consumption) with 5 servings of vegetables (80-120g per serving) per day for 4 weeks on blood lipids and other cardiometabolic outcomes. Previous studies indicate the potential to see significant effects in this population and within this amount of time. Importantly, the investigators will also be including a weekly cooking demonstration as part of the intervention, which provides an essential hands-on participatory component and allows participants to connect with one another in a group setting, which aids in acceptability and adherence to dietary interventions. The investigators hypothesize that 4 weeks of daily supplementation with 4-5 servings of vegetables will significantly improve LDL-C and other cardiometabolic outcomes in healthy adults.


Eligibility Criteria:
Inclusion criteria:

* 18-65 years of age
* Consuming a typical American diet (i.e. not engaged in a structured diet)
* Willing and able to eat vegetables provided (i.e. not allergic or adverse to vegetables provided).

Exclusion criteria:

* Pregnant or lactating
* Participants who currently eat 5+ servings/cups of vegetables per day (excluding tomato paste/sauce, and fried potatoes 'French fries')
* Any condition that would interfere with the participant's data, at the study team's discretion.
Intervention Study to Evaluate a Probiotic in Mild Atopic Dermatitis Young Patients

The aim of the study is to evaluate the beneficial effect of a probiotic preparation with an antiinflammatory and modulating activity on immunological processes, with positive results on different inflammatory and atopic conditions.

In this study the investigators evaluate the safety and efficacy of a probiotic formulation in the reduction of symptoms and use of topic and systemic corticosteroids and antihistamines in the treatment of mild atopic dermatitis according to Hanifin and Rajka diagnostic criteria for atopic dermatitis, with a SCORAD (Scoring Atopic Dermatitis) index of 20 to 40, in patients 4 to 18 years old, that require the use of said drugs due to disease flare-ups, and to whom the usage of topic corticoids to control said flare-ups is indicated.

Eligibility Criteria:
Inclusion Criteria:

* patients that are 4 to 17 years of age.
* Patients diagnosed of atopic dermatitis according to Hanifin and Rajka diagnostic criteria for atopic dermatitis.
* Patients with a SCORAD score ranging from 20 to 40.
* Patients that are actually using, or in which the use of topic corticosteroids to treat the atopic dermatitis flare-ups.
* Patients whose parents or legal representative have signed the informed consent. If the patient is 12 year old or older, the patient has to sign a consent to enter the trial.

Exclusion Criteria:

* Pregnancy.
* Breastfeeding.
* Women of childbearing age that do not make a commitment to use any effective contraceptive method.
* Phototherapy treatments to atopic dermatitis
* Systemic corticoid therapy in the last two months.
* Immunosuppressive or cytostatic treatment in the last two months.
* Probiotic treatment in the last two months.
* Systemic antibiotic in the last four months.
* Fever (axillary temperature \> 37ºC or equivalent)
* Severe allergic diseases-
* Immunodeficiency or cancer related processes.
* Other dermatological pathologies that could difficult the atopic dermatitis evaluation, or that require the continued use of topic corticosteroids.
* Any contraindication to any product or drug used during the trial, according to their technical files.
* Participation in any drug clinical trial in the last 3 months.
Comparison of Two Continuous Positive Airway Pressure Systems

Randomised crossover trial of a novel and traditional Continuous Positive Airway Pressure (CPAP) system in Obstructive Sleep Apnoea patients.


Eligibility Criteria:
Inclusion Criteria

* Participant is willing to provide written informed consent
* Participant is able to read and comprehend written and spoken English
* Participant is ≥ 18 years of age
* Participant has been diagnosed with Obstructive Sleep Apnoea (OSA)
* Participants has been established on Continuous Positive Airway Pressure (CPAP) for ≥ 6 months
* Participants is currently using the same mask type/variant as the interventional mask system to be evaluated
* Participants is able to participate for the duration of the study

Exclusion Criteria

* Participant is not willing to provide written informed consent
* Participant is unable to read and comprehend written and spoken English
* Participant is \< 18 years of age
* Participant has not been diagnosed with Obstructive Sleep Apnoea (OSA)
* Participant has not been established on Continuous Positive Airway Pressure (CPAP) for ≥ 6 months
* Participant is not currently using the same mask type/variant as the interventional mask system to be evaluated
* Participant is unable to participate for the duration of the study
* Participant is pregnant
* Participant is established on bi-level support therapy
* Participant, or participants bed partner, has metallic implants in head neck or chest
* Participant has a with a pre-existing lung disease or a condition that would predispose them to pneumothorax (e.g. Chronic Obstructive Pulmonary Disease (COPD), lung cancer; fibrosis of the lungs; recent (\< 2years) case of pneumonia or lung infection, lung injury)
* Participant is unsuitable to participate in the study in the opinion of the researcher
One Step at a Time: An Intervention to Reduce Sedentary Behavior Among Working Adults

The proposed study will test the preliminary efficacy of a novel 12-week social cognitive theory-based intervention that will target reducing daily sitting time and increasing exercise participation among middle-aged working adults. This is a population highly susceptible to excessive sedentary time and low levels of exercise engagement. This two-arm randomized controlled trial (RCT) will examine the preliminary efficacy of decreasing sedentary time in addition to increasing moderate-vigorous intensity physical activity (MVPA) engagement, compared to a group which only receives MVPA promotion.


Eligibility Criteria:
Inclusion Criteria:

* 45-65 years of age by study start date
* Hold full-time employment (≥ 30 hours/week) at one or more jobs
* Hold a sedentary-based job (which also allows for ability to freely move about during the workday)
* Low active (engage in ≤2 days of 30+ minutes of structured moderate-vigorous intensity exercise/week)
* Physician's consent to participate in aerobic testing and/or the exercise program (if needed based on Physical Activity Readiness Questionnaire responses)
* Ambulatory
* Absence of health conditions that may be made worse by exercise
* Ability to complete all testing assessments in-person
* Access to a laptop/desktop/phone with Zoom web-conferencing software
* Fluent in English

Exclusion Criteria:

* Under 45 or over 65 years of age
* Not holding full-time employment (work \< 30 hours/week at one or more jobs)
* Hold a job(s) which is classified as light, medium, heavy, or very heavy work
* Hold a sedentary-based job which does not allow for free movement throughout the workday (i.e., bus driver)
* High active (engage in \> 2 days or 30+ minutes of structured moderate-vigorous intensity exercise/week)
* Non-consent of physician
* Non-ambulatory (i.e., use of walkers, wheelchair, cane, etc.)
* Presence of health conditions that may be made worse by exercise.
* Unable to complete assessments in-person
* No access to laptop/desktop/phone with Zoom software
Evaluating the Efficacy of the Combination of Multi-zonal Contact Lens and Atropine for Controlling Myopia Progression

The aim of the study is to explore efficacy of combination Atropine and multifocal CL. Randomized Control Trial including 4 arms: Atropine / multizonal CL; Atropine/ SV CL, Placebo drop/ multizonal CL; Placebo drop/ SV CL. Followed over 1 year with outcome measure of change in spherical equivalent and axial length.

see above

Eligibility Criteria:
Inclusion Criteria:

* Between 7 and 12 (inclusive) years of age at the time of screening.
* spherical equivalent of cycloplegic objective refraction (by autorefraction) range of -0.75 D to -4.50 D (inclusive) in each eye.
* Refractive cylinder less than 1.12 D (inclusive)
* Best-corrected visual acuity (BCVA) of 0.04 logMAR or better in each eye, with difference less than 0.20 logMAR between eyes.
* Have normal eyes (i.e., no ocular medications or infections of any type).

Exclusion Criteria:

* Past or current use of myopia control treatment or involvement in previous myopia control study
* Any current or seasonal use of ocular medication (eg. for allergy or chronic blepharitis).
* hypersensitivity or allergic reaction to atropine, cyclopentolate, topical anesthetics or study approved rewetting drop solutions available in local markets.
* previous history or signs of a contact lens-related corneal inflammatory event (e.g., past ulcer or scar) that may contraindicate contact lens wear.
* Any ocular allergies, infections or other ocular abnormalities that are known to interfere with contact lens wear and/or participation in the study. This may include, but not be limited to entropion, ectropion, extrusions, chalazia, recurrent styes, ocular hypertension, glaucoma, history of recurrent corneal erosions, aphakia, uveitis, severe keratoconjunctivitis sicca, keratoconus, keratoconus suspect, and pellucid marginal degeneration.
* Grade 3 or greater palpebral conjunctival observations or any other Grade 2 or greater slit-lamp findings (eg. edema, corneal neovascularization, corneal staining, conjunctival injection) on the ISO 11980 classification scale.
* Any central corneal scar or corneal distortion resulting from ocular diseases or previous hard or rigid permeable contact lens wear.
Virtual Support, Real Impact: Effectiveness of Tele-nursing in Alleviating Chemotherapy Symptoms Among Cancer Patients

This quasi-experimental study evaluated a tele-nursing educational program's impact on improving the quality of life and managing chemotherapy-related symptoms in 74 adult cancer patients at Mansoura University Hospital in Egypt. Delivered via Telegram, the program involved weekly educational sessions, aiming to enhance symptom management and quality of life.

The study aimed to assess the effectiveness of a tele-nursing educational program in managing chemotherapy-related and cancer-related symptoms and improving the quality of life among adult cancer patients. Conducted at the Oncology Center at Mansoura University Hospital in Egypt, the study recruited 74 participants who completed structured interviews detailing their demographics, medical history, symptom severity (using the MDASI-A tool), and quality of life (using the QOL-ACD tool). The intervention, delivered via a Telegram group, included weekly educational sessions focused on managing chemotherapy symptoms. The sessions featured educational content and feedback, with outcomes measured through changes in symptom severity and quality of life scores before and after the intervention. This approach highlighted the program's potential to enhance patients' overall well-being and symptom management.

Eligibility Criteria:
Inclusion Criteria:

* • Diagnosed with cancer and receiving treatment at an outpatient chemotherapy center

  * Age from 20 less than 60 years.
  * Accept to participate in the study.
  * Had smart phones linked with internet
  * Educated and able to use Zoom and Telegram applications

Exclusion Criteria:

* • Having active, serious physical disease

  * Patients with mental disease.
The Effect of Inactive and Active Vitamin D on Serum Sclerostin/dickkopf1 Levels

The purpose of this study is to compare the effect of inactive and active vitamin D on serum sclerostin and dickkopf1 levels.


Eligibility Criteria:
Inclusion Criteria:

* Healthy male volunteer older than 20 years

Exclusion Criteria:

* Subjects with bone and mineral metabolism disorders
* Subjects with kidney or liver diseases
* Subjects with uncorrectable hypercalcemia or hypocalcemia
* Subjects with chronic gastrointestinal disorders or malabsorption
* Subjects taking medication related to bone loss
Study Evaluating SKI-606 Administered to Healthy Subjects

Safety and tolerability of SKI-606 in healthy subjects; the influence of food intake on the same.


Eligibility Criteria:
Inclusion Criteria:

* Healthy
The Effect of Different Measurement-manufacturing Techniques on Load Distribution in Amputees

Alignment of the prosthesis with the stump is performed through the socket. Good socket stump fit provides near-normal posture and weight-transfer pattern. It also ensures that the walk is painless and low-energy. Recently, studies have been carried out to use 3D printers in socket production. 3D method is accepted as an effective and reliable method in prosthetic socket production. The purpose of this study is to compare the pressures distrubution in the sockets produced by conventional and 3D scanners and printers in the transtibial amputee.


Eligibility Criteria:
Inclusion Criteria:

* Being unilateral transtibial amputation
* To have enough perception level to understand and apply commands

Exclusion Criteria:

* To have orthopedic, neurological, etc. disorder other than amputation that will affect posture or gait
* The presence of pain that will affect the posture or walking pattern
* Wound / tenderness on the stump
* Visual impairment that will affect the posture or gait pattern
* Use of any assistive device (walking stick, canary, etc.) during walking
Molecular and Organizational Changes in the Human Oral Mucosa During Aging

The objective of this interventional with mucosa et saliva samples, monocentric, transversal and pilot study is to extract vibrational, thermal and dielectric markers obtained by Differential Scanning Calorimetry, Thermo-Stimulated Currents and Fourier Transform Infrared spectroscopy on oral mucosa and saliva samples collected from 66 patients divided in two groups (20-40 and 70-90 years old).

Edentulism is prevalent in elderly people and the current care is the use of removable denture based on edentulous jaw regions. Nevertheless, the close and extended contact of denture base with mucosa and the transmission of chewing movement trough the complete denture leads to a weakening of supporting tissues in the medium to long term. This embrittlement may be accompanied by pain, compromising the proper integration of complete denture. In geriatrics, the peculiar weakness of bearing surfaces, connected to physio-pathological conditions as well as the decrease of adaptability and resistance further complicate the biomechanical integration of this kind of prosthesis. It has been shown that chronical ageing induces a decrease of resiliency and hydration of oral mucosa, associated with a decrease of epithelium thickness; nevertheless few studies have been performed at the molecular and supramolecular level to characterize this mucosa. Techniques of material characterization (Fourier transform Infrared spectroscopy, Differential scanning calorimetry (DSC), Thermostimulated currents (TSC), have shown their ability to follow hydric, molecular and structural modification of dermis upon ageing. In accordance with this study, the distribution of thermal, vibrational and dielectric markers of oral mucosa will be extracted in two age groups. The principal hypothesis of the research is the possibility to identify specific markers and to follow molecular and organizational changes induced by ageing (intrinsic ageing or extrinsic ageing due to prostheses wearing). The characterization of saliva by Fourier transform infrared spectroscopy (FTIR) shows promise in quantifying the biochemical components of this biofluid. Some vibrational saliva biomarkers have high diagnostic potential (physiological stress, diabetes, salivary lithiasis, carcinomas, periodontitis).This study is a first step to redefine the specification for the most appropriate biomaterial in removable prostheses.

Eligibility Criteria:
Inclusion Criteria:

* Patient requiring a classic dental surgery (extraction, implantology...) at the Toulouse University Hospital,
* Between the ages of 20 and 40 or between 70 and 90 years

Exclusion Criteria:

* Patient with gastrotomy probes or chemotherapy, palliative care (or with a life expectancy of less than 30 days),
* Patient with surgical contraindication: allergy to local anesthetics, major hemorrhagic risk: patient on unbalanced Anti Vitamin K, patient on new anticoagulants not relayed or not discontinued,
* Patient at high risk of infectious endocarditis
* Patient under safeguard of justice.