cyrilzakka/clinical-trials huggingface dataset:
Family Based Treatment for Weight Loss With Breakfast Prescription

The purpose of this study is to evaluate whether a behavioral weight loss group in conjunction with a prescribed breakfast can help children between 8 and 12 years of age change their behaviors to help them lose weight and become healthier.

The purpose of this application is to evaluate the acceptability and initial efficacy of consumption of an egg breakfast, compared to a cereal breakfast, in the context of Family-based Behavioral Treatment (FBT) with overweight and obese children and their parents. Investigators will randomize 66 parents and their overweight and obese child (85-99.9%BMI) to FBT+egg or FBT+cereal groups. Families will eat their assigned breakfast (eggs or cereal) 5 out of 7 days during the 4 month FBT treatment. However, all other aspects of FBT will be the same in the two groups. Children and parents will complete assessments at three time points; baseline, post-treatment and 4-months post-treatment.

Eligibility Criteria:
Inclusion Criteria:

1. Children between the ages of 8 and 12 years old;
2. BMI ≥85th% and \<100% overweight
3. Children with parents who are willing to attend 16 weekly group sessions and be randomized to either treatment arm;
4. Have at least one parent who is overweight or obese (BMI≥25);
5. Children and parent who endorse liking of both eggs and cereal
6. Parents who speak English at a 5th grade level.

Exclusion Criteria:

1. Children with serious medical conditions that affect their weight;
2. Children taking medication that affect appetite or weight;
3. Children with severe developmental delay or disability that would affect participation;
4. Children or parents with psychological illness that would limit treatment participation;
5. Families who plan to move out of the area within the time frame of the study.
The Impact of Food Order on Glycemic Excursions in Type 2 Diabetes Assessed by Continuous Glucose Monitoring

The purpose of this study is to explain the effect of food order/nutrient sequencing on glycemic excursions over a 2 week period, utilizing a device known as a continuous glucose monitor (CGM), for people who have been diagnosed with Type 2 Diabetes Mellitus and treated with metformin. This research study is being done because recent studies demonstrate that besides carbohydrate amount and type, the sequential order of macronutrient consumption during a meal has a significant impact on post-meal glucose levels.


Eligibility Criteria:
Inclusion Criteria:

* Metformin-treated type 2 diabetes of less than 10 years duration
* Must be on a stable dose of metformin for at least 1 month
* HbA1c ≤8.5 percent

Exclusion Criteria:

* Relevant food allergies
* Oral steroid therapy within 90 days of enrollment
* Anti-diabetic medications other than metformin
* History of bariatric surgery
* Pregnant women
* Any participant deemed unsuitable in the investigator's opinion
Effectiveness of the Neural Mobilization on Upper Limb Functionality in Patients With Acquired Brain Injury

The main objective:

To determine changes in physiological and structural properties of upper limb muscles with spasticity in patients with acquired brain injury after applying neural mobilization improving their functional performance, their participation in society and quality of life.

Hypothesis:

Peripheral nerve mobilizations performed with neurodynamic techniques in upper limb in patients with acquired brain injury, generate changes at structural and physiological level, favoring the performance of daily life activities and improving the quality of life.

Randomized clinical trial with blinding of the subject, the evaluator and the person analyzing the data.

In the experimental group will be performed neural mobilitazion technique, while in the sham a technique to mimic neurodynamic.

The assessment will be made by a single evaluator.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of acquired brain injury (hemiplegia-hemiparesis)
* Ages between 25 and 50 years

Exclusion Criteria:

* Unable to understand and respond to verbal instructions
* Absence of voluntary movement in the upper limb
* Take medicine for spasticity
* Botulinum toxin infiltration in the last 6 months
Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth

This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing MIH-affected teeth.

This randomized clinical trial study aims to investigate the effectiveness of nano-hydroxy apatite crystal varnish, and potassium nitrate gel compared to fluoride varnish, in reducing dentin hypersensitivity, improving a child's oral hygiene, and gingival health, oral health-related quality of life, preventing post-eruptive enamel breakdown, and dental caries, along with economic evaluation.

Eligibility Criteria:
The research unit of this study will be the MIH-affected permanent tooth, in children aged from six to ten years, from either gender.

Inclusion criteria:

Participants related criteria:

1. Children aged from six to ten years old.
2. Medically free children according to the history taken from their parents.
3. Children who are categorized as Class I or II according to the American Society of Anaesthesiologists (ASA).
4. Children whom their parents accept to comply with the follow-up visits.
5. Children who accept, and their guardians, to participate in the study by signing the informed consent.
6. Children with no more than four cavitated primary teeth.

Tooth related criteria:

1. The diagnosis of MIH will be done as per the Wurzburg concept, 2023 MIH diagnostic criteria:

The child will be confirmed to have MIH if any of the following characteristics are apparent:

* affected teeth show a clearly defined opacity at the occlusal and buccal surfaces of a tooth,
* defects vary in shape, size, and pattern,
* white, cream-colored, or yellow-brown color deviations are recognizable,
* defects variably vary in size,
* teeth with hypersensitivity are present,
* teeth have an atypical restoration,
* permanent teeth for (suspected) MIH reasons are missing (extractions),
* combinations of the above characteristics are present.

  1. MIH-affected permanent teeth, suffering from dentin hypersensitivity, (MIH-TNI 3, 4a).
  2. Positive Schiff Cold Airblasting Sensitivity score (score 1, 2, or 3).

     * Exclusion criteria:

Participants related criteria:

1. Children with severe behavioral or emotional disabilities.
2. Children who received analgesics within the last 24 hours before the procedure.15
3. Patients who are using chlorhexidine-based gels or mouthwashes.

Tooth related criteria:

1. A tooth with signs and symptoms of irreversible pulpitis.
2. A tooth with signs and symptoms of necrotic pulp.
3. Sealing therapy or application of desensitizing agent on the MIH teeth within one month before participation in the study.
4. Presence of dental caries on the MIH-affected permanent tooth.
5. Presence of restoration(s) on MIH-affected permanent tooth.
Evaluating Ureteral Length Using Computed Tomography (CT)

Proper selection of ureteral stent length might help in reducing comorbidities associated with ureteral stenting, currently there is no standardized way of measuring ureteral length.

Measurement of ureteral length according to Computed Tomography (CT) scan might provide useful information when selecting the length of a ureteral stent. Our aim in this study is to compare ureteral measurements using CT scan and measurement of actual ureteral length measured during ureteral stenting.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing planned procedure involving ureteroscopy or ureteral stenting
* Abdominal CT scan performed within 6 months prior to intervention

Exclusion Criteria:

* Known iodine sensitivity
* Patients with fever or hemodynamic instability planned for urgent operation
* Severe immune compromized patients
* Severe thrombocytopenia \< 50,000
Learning Process of Fourth Year Medical Students During a Doctor-patient Relationship Training

This study aims to explore learning process for undergraduate students in this doctor-patient relationship course. This study is one of the 3 studies included in a PhD on learning process during simulation training in psychiatry. The results of this 3 studies will aim at building a formative and summative assessment tool of competences specific to this pedagogic context.

Methodology: Mixed method study with:

Qualitative : Grounded Theory analysis of :

* Semi-structured interview of learners and teachers
* Learning written traces of students

Quantitative features:

* Self-reported questionnaires on satisfaction
* Sociodemographical data and others questions

Eligibility Criteria:
Inclusion Criteria:

* Age \> to 18 years old
* Undergraduate medical fourth-year student of Paris Descartes University
* Taking part in an obligatory doctor-patient relationship training, including role play, simulated consultation, Balint group and courses
* Draw by lot
* French or English language
* Agreement

Exclusion Criteria:

* Refusal of agreement
* Undergraduate medical fourth-year student of Paris Descartes University who couldn't take part in an obligatory doctor-patient relationship training, including role play, simulated consultation, Balint group and courses
ctDNA Dynamic Monitoring and Its Role of Prognosis in Stage I NSCLS by NGS

CtDNA detection is a noninvasive detection method, and the second generation of high-throughput gene sequencing (NGS) is an important means of detecting ctDNA, which can detect trace ctDNA from smaller plasma samples. This project is to study the role of ctDNA dynamic monitoring of stage I NSCLC by NGS technique to verify the prognostic predictive effect of ctDNA .

CtDNA detection as a noninvasive detection method, can truly reflect the real tumor tissue gene mutation map and frequency, is the evaluation of therapeutic effect and the important monitoring indicators of clinical follow-up after treatment. The second generation of high-throughput gene sequencing (NGS) is an important means of detecting ctDNA, which can detect trace ctDNA from smaller plasma samples. The ctDNA dynamic monitoring of stage I non-small cell lung cancer (NSCLC) was performed by the second generation gene sequencing (NGS) technique to verify the prognostic predictive effect of ctDNA in stage I NSCLC patients without radiotherapy and targeted therapy.

Eligibility Criteria:
Inclusion Criteria:

* Postoperative histopathological diagnosis of TNM stage IA / IB NSCLC with R0 resection;
* No adjuvant chemotherapy, radiotherapy, targeted drug therapy or biotherapy after surgery;

General selection criteria:

* Men or women of age ≥18 years and \<75 years old;
* ECOG behavior status score 0 to 1;

Exclusion Criteria:

* Patients with other cancers other than NSCLC within five years prior to this study;
* who can not get enough tumor histological specimens (non-cytological) for analysis;
* human immunodeficiency virus (HIV) infection;
* NSCLC mixed with patients with small cell lung cancer;
* pregnant or lactating women;
* There is a clear history of neurological or mental disorders, including epilepsy or dementia;
* Conditions that investigators think is not suitable for inclusion.
TRAM Procedure in Ambulatory Surgical Facility: Quality of Recovery Outcomes

Specific Aim: To assess the quality of recovery of patients following early discharge (18 hrs) after pedicled TRAM flap breast reconstruction. Quality of recovery will be assessed using a 27-item validated questionnaire, QoR-27 at discharge, and on Post Operative Days (POD) 2, 4 and 7. In addition a 100 mm Visual Analog Score (VAS) for Pain will be completed on discharge from the recovery room, discharge from hospital and on POD 2, 4 and 7.

Clinical Relevance: Postoperative recovery is a complex process related to various outcomes such as physiological endpoints, incidence of adverse events and change in psychological status. Previous studies of recovery after surgery and anesthesia have focused primarily on the physiological endpoints and the incidence of adverse events. Much of the work has occurred in specialties dealing with chronic disease states such as cancer, rheumatology and musculoskeletal disorders. There is clearly a need to focus on recovery outcome measures in the ambulatory population for postoperative recovery. Here the investigators propose to measure postoperative recovery outcomes within the first week following a TRAM flap reconstructive procedure using a validated postoperative quality of recovery instrument (QoR-27) and a 100 mm VAS for pain.

Women's College Hospital is the first and only independent ambulatory care hospital in Ontario, and the only hospital in Ontario with a primary focus on women's health. Patients undergoing breast reconstruction following breast cancer at our institution are now undergoing expedited discharge at 18 hrs postoperatively. To facilitate next day discharge, a multidisciplinary group was formed to determine the best evidence for perioperative care to ensure patient safety and excellent postoperative recovery. Minimizing length of stay has obvious cost savings for hospitals, but for patients the advantages include minimizing exposure to hospital-acquired infections and an earlier return to their more familiar home environment. The need to balance the advantage of early discharge to patient complications, however, must be addressed. As other hospitals across the country face the same length of stay constraints as has been our experience, this study will provide important data on the quality of recovery of patients undergoing early discharge following breast reconstructive surgery.

Eligibility Criteria:
Inclusion Criteria:

* Women undergoing any type of TRAM flap
* Age\<75 yrs
* Non-smoker

Exclusion Criteria:

* History of chronic pain or psychiatric disturbance
* History of chronic use of opioid medications
* Allergy to local anesthesia or opioid medication
* Inability to communicate in English
* BMI\>35
Condition of Submental Fullness and Treatment Outcomes Registry

The primary objective of this registry is to develop a comprehensive understanding of the condition of submental (SM) fullness due to submental fat (SMF), how it is treated in current clinical practice, and the risks and benefits associated with its treatment.


Eligibility Criteria:
Inclusion Criteria:

* Adult male and female patients, aged 18 years and above, presenting with SM fullness due to the accumulation of unwanted SMF, and considered by their treating physician to be a candidate to receive treatment of SM fullness by reduction of SMF, if the patient decides
* Signed informed consent by the patient, obtained before any study-related activities are undertaken
* Willing to complete all patient assessment questionnaires
* Signed release form by the patient, permitting abstraction of the patient's medical records at baseline and during participation in the registry

Exclusion Criteria:

* Severe skin laxity, defined as superficial wrinkling, loose skin separated from deeper neck structures, and/or marked skin redundancy (draping and/or sagging), per the physician's judgment
* Any other cause of fullness in the SM area (eg, thyroid enlargement, cervical adenopathy) other than localized SMF
* Participating in an interventional clinical study, currently or within 30 days before enrollment
Preliminary Exploration of Applying Multi-person Simulation Training to Improve Nurse-led Burn and Scald Nursing Care

The purpose of this study was to compare the learning performance of trainees before and after learning burns and scald nursing care by applying the burns and scald virtual reality (VR) training module multi-person interactive training in different places and the traditional training model with a high-fidelity patient.

The clinical instructors, standard practice nurses, training content, and assessment process were the same for the experimental and control groups, except for the training methods of the interventions. A pre-recorded instructional video on burn care was provided to each participant one week prior to the experiment for self-study. The experiment procedure includes research description, pre-test and pre-test questionnaire (about 10 minutes), VR hands-on teaching or environment familiarization phase (about 10 minutes), multi-person simulation training (about 15 minutes) and post-test debrief (about 5 minutes), post-test and questionnaire (about 10 minutes). After completing all experiments, the collected data will be analyzed by the researcher using SPSS version 22.0 for descriptive, t-test, and other statistical analyses.

Eligibility Criteria:
Inclusion Criteria:

1. people who are above 20 years old, with a nurse practitioner certificate and an ACLS or AHA certificate within the validity period.
2. people who are interested in learning the role of a team leader in burn and scald care.
3. people who have never used an interactive virtual reality (VR) environment device.

Exclusion Criteria:

1. people who are prone to vertigo or poor balance and are prone to motion sickness.
2. people with a history of epilepsy.
3. eye surgery or injury within the past 6 months.
4. people with facial wounds that prevent them from wearing VR glasses.
Effect of Baclofen Treatment on Nocturnal Muscle Cramps in Patients With Lumbar Spinal Stenosis: a Randomized Clinical Trial

Nocturnal calf cramps is a common complaint in patients with lumbar spinal stenosis. The purpose of this study is to evaluate the effect of baclofen in lumbar spinal stenosis patients receiving conservative therapy. We will compare pain score, insomnia severity, functional ability and patient satisfaction between control (conservative management for spinal stenosis) and baclofen group (conservative management for spinal stenosis plus baclofen treatment).


Eligibility Criteria:
Inclusion Criteria:

1. diagnosed lumbar spinal stenosis with MRI finding
2. nocturnal calf cramps symptoms at least once per week

Exclusion Criteria:

1. electrolyte disorder
2. congenital muscle disease
3. muscle cramps related medication (statins, diuretics, calcium channel blockers, anticonvulsants etc.)
4. cognitive impairments
Phase 1 Safety and Tolerability of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib Alone

The purpose of this study is to determine the maximum tolerated dose and characterize the safety profile of durvalumab (MEDI4736) in combination with dabrafenib and trametinib or with trametinib alone in participants with metastatic or unresectable melanoma with BRAF-mutation positive or wild-type (WT) BRAF, respectively.

This is a multicenter, open-label study with a dose escalation phase followed by an expansion phase of durvalumab administered in combination with dabrafenib and trametinib or with trametinib alone in participants with BRAF V600 mutation-positive and WT unresectable or metastatic melanoma, respectively.

Eligibility Criteria:
Inclusion Criteria:

* Adults \>= 18 years old
* Histologically confirmed cutaneous melanoma that is either Stage IIIc (unresectable) or Stage IV (metastatic) and determined to be BRAF V600E or V600K mutation-positive (cohort A) or mutation-negative (cohorts B and C)
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Measurable disease by radiographic or physical examination
* Adequate organ and marrow function
* Willingness to provide consent for biopsies positive or BRAF WT measurable disease and adequate organ and marrow function

Exclusion Criteria:

* Prior treatment with a BRAF inhibitor or MEK inhibitor
* Any prior Grade \>= 3 immune-related adverse event while receiving immunotherapy
* Active or prior documented autoimmune disease within the past 2 years
* History of or current risk for retinal vein occlusion (RVO) or central serous retinopathy (CSR)
* History of or current cardiovascular risk including myocardial infarction, \>= Class II congestive heart failure, uncontrolled arrhythmias, or refractory hypertension
* Active, untreated central nervous system (CNS) metastases
* Women who are pregnant or lactating
Attentional Control

The project is dedicated to understanding the integration within the brain of signals of different natures that contribute to attentional control. The investigator will make use of standardized experimental displays involving the discrimination of a target (tilted-bar) presented together with 3 distractor items, with one stimulus in each visual quadrant. Across three fMRI experiments in healthy participants, the investigator will manipulate different types of signals that will guide the subject's attention towards one of the four quadrants: Exp 1 - task instruction \& item salience; Exp 2 - probabilistic target location; Exp 3 - probabilistic reward. The investigator expects that irrespective of the nature of the control signal, activity in dorsal parietal cortex will index the currently relevant/attended location. Moreover, The investigator expects that upon changes of the most relevant location, one will observe activation of the ventral parietal cortex, plus increased inter-regional connectivity between ventral and dorsal parietal regions - again irrespective of the nature of the attention guiding signals.


Eligibility Criteria:
Inclusion Criteria:

* Be 18 to 40 years old

Exclusion Criteria:

* Previous neurologic or psychiatric disease.
* Cognitive deficits restricting understanding of the tasks.
* Pregnant or breath-feeding women.
* Persons under guardianship, curator or any other administrative or judicial measure of deprivation of rights or liberty.
* Subjects currently participating in other study.

Additional exclusion criteria for a functional magnetic resonance imaging (fMRI) recording:

* Neurologic, cardiac electrostimulation or defibrillator.
* Cardiac prostheses
* Intracranial clips or clamps
* Cerebrospinal fluid disorders
* Metal particles in the eyes
* Metal dental or articular prostheses
* Diffusion pomp or other infusion system
* Claustrophobia
* Head tattoo, make-up, hair gel
* Have any copper intrauterine device
ArmAssist Robotic Device for Arm Training

ArmAssist is low cost simply robotic devise for arm training and assessment. It is suitable for extended home rehabilitation and prolonged hospital rehabilitation without therapist supervision. The device contains several games which are structured as exercise for disabled patients. The primary aim of this study is to correlate efficacy of the arm training with ArmAssist robot system to conventional care modified by duration and structure of exercise. The secondary aim of this study is to measure the correlation between standard clinical assessment scales and ArmAssist-based assessment metrics.


Eligibility Criteria:
Inclusion Criteria:

* unilateral paresis;
* ability to understand and follow simple instructions;
* minimum ability to perform active movements, even though trunk compensation, using the shoulder and/or the elbow joints.

Exclusion Criteria:

* bilateral impairment;
* severe sensory deficits in the paretic upper limb;
* cognitive impairment or behavioral dysfunction that would influence the ability to understand or perform the experiment;
* inability to provide informed consent;
* other current severe medical problems.