cyrilzakka/clinical-trials huggingface dataset:
Socket Shield Technique With or Without Flap Elevation

It is aimed to compare the bone changes and the amount of marginal bone loss after prosthetic loading around the immediately placed implants using the Socket Shield Technique with or without flap elevation.

Temporary prostheses will be applied to patients in the flap and flapless surgery group 1 week after the surgical procedure, and permanent prostheses will be placed 3 months later. From this date, clinical controls will be made in the 1st, 3rd, 6th months and 1st year.

During these controls, biological complications (peri-implant mucositis, peri-implantitis), implant failure and survival rates, and complications related to the socket shield (socket shield exposure, infection) will be evaluated. Marginal bone loss around the implants and bone resorption in the horizontal and vertical directions will be compared between the two groups with cone beam computed tomography taken at the 1st year follow-up.

The Oral Health-Related Quality of Life Scale will be applied in the session where the temporary prosthesis is applied 1 week after the surgery, in the 1st month clinical control and in the 3rd and 6th month clinical control after the permanent prosthesis application, in order to evaluate the quality of life related to the surgical and prosthetic application of the patients in both groups, and comparisons between groups will be made.

In addition, intraoral photographs will be taken from the patients for aesthetic evaluation before the surgical procedure, at the 1st, 3rd and 6th month clinical control sessions. Pink Aesthetic Score (PES) and White Aesthetic Score (BES) will be evaluated on the photographs, and a comparison will be made between groups in terms of scores.

Eligibility Criteria:
Inclusion Criteria:

* Being systemically healthy (ASA classification I-II)
* Being over 18 years old
* Not smoking
* Having good oral hygiene
* Upper incisors and premolars that cannot be restored and have extraction indications
* Periodontally healthy, non-mobile teeth
* The amount and quality of bone suitable for immediate implant placement

Exclusion Criteria:

* Periodontally unhealthy teeth
* Teeth with vertical root fracture on the buccal surface
* Teeth with a horizontal fracture below the bone level
* Teeth with external and internal resorption affecting the buccal part of the root
* Patients who are pregnant or suspected of pregnancy
Exploring Liver and Muscle Fat Content Using MRI

The aim of our study was to compare the difference of fatty infiltration in liver and muscle using magnetic resonance imaging (MRI) between overweight as well as obese polycystic ovary syndrome (PCOS) cases and body mass index (BMI)-matched women without PCOS, identifying the possible influence factors.


Eligibility Criteria:
Inclusion Criteria:

(1) subjects with a body mass index (BMI) ≥ 24 kg/m2; (2) subjects aged between 18 and 40 years; (3) subjects who had not received any prescription or non-prescription drugs that affect insulin sensitivity or ovarian function, including hormonal contraceptives and metformin, within three months before the trial; (4) PCOS diagnosis fulfills the Rotterdam 2003 criteria phenotype B with hyperandrogenism (HA) and oligo-/anovulation \[29\]; (5) subjects who had not received medication that impacts lipid metabolism (fibrates, statins, antioxidants and diuretic) in the recent 3 months; (6) subjects who did not intend to become pregnant and use barrier contraception; (7) subjects who did not change their lifestyle, including physical activity and eating habits, during the study period.

Exclusion Criteria:

-
A Prospective Comparison Between Ureteral Stent and Nephrostomy Tube for an Urgent Drainage of Obstructed Kidney

Kidney obstruction might be caused by a stone in the urinary tract. In case of accompanying fever or renal failure, an urgent drainage might be needed. This can be done either by placing an ureteral stent or a nephrotomy tube. Only limited number of studies examined the question which of the two is preferred. A debate exist regarding the effectiveness of each procedure to improve symptoms, renal function and treating an infection. Our goal is to resolve this debate and to state whether one way is preferred on the other.


Eligibility Criteria:
Inclusion Criteria: Patient suffering from obstructed kidney by a stone and at least one of these situations:

1. fever (above 38c)
2. A rise in creatine to above 1.5
3. Pain resistent to multiple analgetic treatments

Exclusion Criteria:

* Patients with medical condition that prevent the use of one of the procedures
The Organ Protection of Astragalus in Subjects With Metabolic Syndrome

Metabolic syndrome have the damages on tissues and organs in heart、kindey and vessels. In this study, prospective randomized, controlled, parallel designed ,different doses of Astragalus Mongolia, Gansu Longxi produce treat on the MS patients, and then use real-time quantitative PCR and Western Blotting to detect the index of oxidative stress 、angiotensin-converting enzyme 2 mRNA expression and proteins.


Eligibility Criteria:
Inclusion Criteria:

1. age 18 years or older, meet the diagnostic criteria of MS
2. non-allergic with the astragalus
3. agree to conduct clinical trials and those who signed the informed consent

Exclusion Criteria:

1. patients with resistant hypertension
2. renal disease requiring dialysis
3. heart failure NYHA ⅢorⅣ;
4. complications of diabetes
5. arteritis
6. cancer
7. thyroid disease
8. unstable coronary heart disease
9. peripheral vascular disease
10. acute cerebral vascular disease11.pregnancy、 planned pregnancy
11. patients with anti-oxidants
12. acute infection
13. other organic dysfunction, such as the liver, respiratory system, blood system, and other rheumatic diseases.
Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin

The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years old
* Patient with a definite auto-immune encephalitis (Graus and al. 2016)

Exclusion Criteria:

* Uncomplete data in acute phase
* Patient with several antibodies
* Opposition
Cardiorespiratory Exercise & Chinese Medicine for Rehabilitation of Discharged Coronavirus Disease (COVID-19) Patients

Rehabilitation interventions can help to address the consequences of COVID-19, which include medical, physical, cognitive, and psychological related problems. The specific aims of this project are to investigate the effects of a 12-week exercise program on pulmonary fibrosis in recovering COVID-19 patients. A further aim will be to examine how Chinese herbal medicines, gut microbiome, and metabolites regulate immune function and possibly autoimmune deficiency in the rehabilitation process.

The study will develop a new paradigm for patient rehabilitation needed now and in the future. The specific aims of this project are to investigate the effects of a 12-week program with cardiorespiratory exercise and Chinese herbal medicine on recovering COVID-19 patients and to collect qualitative and quantitative data to examine loneliness, anxiety, depression, quality of life, and mental health. A further aim will be to examine how Chinese herbal medicines, gut microbiome, and the metabolites regulate immune function, intestinal permeability, and possibly autoimmune deficiency (AID) in the pathological recovery/rehabilitation process.

In this multicenter, triple-blinded, randomized, parallel groups, controlled clinical trial, the investigator will recruit adult patients with COVID-19 and have been discharged from the hospital in Hong Kong and the Chinese Mainland.

A total of 172 eligible patients will be randomized 1:1:1:1 into four groups: cardiorespiratory exercise plus Chinese herbal medicines group, cardiorespiratory exercise group, Chinese herbal medicines group, and waiting list group for 12-week (3 months) with 12-week follow-up period.

A 4-week pilot study will be conducted to test patient recruitment and maintenance, data collection, instrumentation, and observing the adaptability and practicality of the intervention. Amendments will be made if necessary.

Eligibility Criteria:
Inclusion Criteria:

1. aged 18 years and above;
2. a percentage of predicted forced vital capacity (FVC) \<90%, and/or a percentage of predicted carbon monoxide diffusing capacity \< 90% (King 2014);
3. able to communicate in Cantonese.

Exclusion Criteria:

1. having acute exacerbations in the 12-week preceding recruitment patients;
2. having any contraindications for exercise (e.g., physical disability, uncontrolled mental disorders, unstable heart disease, unable to perform muscle strength tests)
3. Female - Pregnant or plan to become pregnant in the next 1 year
4. Unable to communicate in Cantonese or Mandarin
5. Currently participating in other similar rehabilitation programs or research
Explorative Trial Evaluating the Efficacy and Tolerability of LEO43204 in Moderate to Severe Acne

An exploratory Phase 2, single, centre, prospective, randomized, placebo-controlled, double-blinded, split-pace (left/right) design trial to evaluate the efficacy and tolerability of LEO 43204 in adults with moderate to severe acne.


Eligibility Criteria:
Inclusion Criteria:

* Subjects should be diagnosed with acne vulgaris of the face
* Fitzpatrick skin types I-III (due to lack of safety data for the investigational product in darker skin types)
* Disease severity and total lesion count should be similar in both TAs
* Disease severity grade as moderate to severe according to the investigator's global assessment (grade 3-4)
* Age 18 to 35 years incl.
* Male or female
* Female Subjects must be of either non-childbearing potential or child-bearing potential with a confirmed negative pregnancy test

Exclusion Criteria:

* Subjects with nodulocystic acne, acne conglobata, acne fulminans, secondary acne (e.g. chlor-acne, drug-induced acne)
* Subjects with previous history of keloid formation or post-inflammatory hyperpigmentation
* Systemic retinoids within 12 month or systemic antibiotics within 1 month before Day 1
* Topical retinoids within 3 months before Day 1 or other topical treatments and/or medicated products and cosmetics that in the opinion of the investigator may influence the subjects acne vulgaris (including soaps containing antibacterial agents such as benzoyl peroxide, keratinolytic agents such as salicylic acid, skin fresheners/astringents or aftershave products) within 1 month before Day 1
A Phase I/IIa Clinical Study to Assess the Single and Multiple Ascending Doses of MDR-001 Tablets in Healthy Participants and Obese/ Overweight Participants

To investigate the safety and tolerability after single and multiple ascending doses of MDR-001 Tablets administered orally in healthy participants and obese/ overweight participants.


Eligibility Criteria:
Inclusion Criteria:

* Participants who are aged ≥ 18 and ≤ 55 years at the time of signing the informed consent; no gender restriction.
* Participants with 27 ≤ body mass index (BMI) ≤ 45 kg/m2.
* For male participants, a waist circumference ≥ 90 cm is required, while female participants ≥ 85 cm.

Exclusion Criteria:

* Participants with any condition that increases the risk of bleeding, such as hemorrhoids, acute gastritis, or gastric and duodenal ulcers.
* Participants with personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia 2 (MEN2), or those with hereditary diseases that easily induce to medullary thyroid carcinoma.
* Participants with a history of pancreatitis or symptomatic gallbladder disease.
* Serum calcitonin \> ULN at screening.
* Participants with systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 100 mmHg at screening.
* Participants with ALT \>2 × ULN and /or AST \> 2 × ULN at screening.
* Participants whose fasting triglycerides \> 5.7 mmol/L, total cholesterol \> 7.75 mmol/L, low-density lipoprotein cholesterol \> 4.9 mmol/L at screening.
* Participants with abnormal uric acid levels accompanied by clinical symptoms (those without clinical symptoms can be included).
* Participants with fasting blood glucose levels \> 7 mmol/L.
* Participants with creatinine clearance \< 60 mL/min at screening \[calculation formula: CLcr: (140 - age) × weight (kg) / \[72 × 0.0113 × Scr (μmol/L)\], × 0.85 for females\].
* Participants have experienced significant changes in diet or exercise habits or within ≥5% changes in body weight within 3 months prior to screening.
* Participants with clinically significant ECG abnormality deemed unsuitable participation for study by the investigator; or with ECG QTcF values \> 450 ms for male participants or \> 470 ms for female participants.
M-Health Administered Sleep Treatment to Enhance Recovery in Bariatric Populations (MASTER)

This study is a longitudinal clinical trial designed to assess the feasibility of sleep intervention (Cognitive Behavioral Therapy for Insomnia (CBT-I)) in individuals with insomnia following bariatric surgery.


Eligibility Criteria:
Inclusion Criteria:

* Age 18-64
* Fluency with English
* Willingness to maintain an active telehealth platform account
* Daily access to wireless internet connection or sufficient cell phone service for telemedicine
* Undergone bariatric surgery (Roux-en-Y or vertical sleeve gastrectomy) within past 1-3 years
* Must have experienced \<50% excess weight loss following surgery Clinically significant insomnia (i.e., ISI score \>11)

Exclusion Criteria:

* Patient underwent revision of initial weight loss procedure
* PHQ-9 Depression score \> 15
* GAD-7 Anxiety score \> 15
* Current alcohol or substance abuse
* Current narcotic use
* Unstable major psychiatric condition
* Restless leg syndrome
* Sleep apnea with non-adherence to CPAP intervention (i.e., use of CPAP \<4 nights/week)
* Other problems at investigator discretion
* Vulnerable populations (e.g., adults unable to consent, ages \<18, pregnant women, and prisoners).
Mobile App and Digital System for Patients After Myocardial Infarction

The treatment of acute myocardial infarction (MI) in Poland is at the level of standardized European care. However, the first months after MI are crucial from the perspective of patient's prognosis. It is extremely important to take care of all cardiovascular risk factors.

Mobile application (afterAMI) supported by web system is a novel telemedical tool created to support patient and physician during the process of cardiac rehabilitation. The application has educational model with focus on cardiovascular risk factors and lifestyle after MI. Moreover, there is a module to control vital signs like blood pressure, heart rate, weight and many others. Additionally, application will send reminders for better drug adherence.

100 patients will be recruited to take part in the study. All of which will be hospitalized at the 1st Department and Clinic of Cardiology because of the MI. The aim of the project is to study the impact of application-supported model of care with comparison to standard care. At the end of the study cardiovascular risk factors control will be analysed, as well as rehospitalizations, patient's knowledge regarding risk factors, return to work and quality of life.

This will be a prospective, open-label, randomized, single-centre study. All 100 patients will be observed 6 months after discharge from the hospital. End points will be assessed during control visit 1- and 6-months after inclusion into the study.

This project is an example of a telemedicine solution application into everyday practice, which is consistent with multiple international cardiac societies.


Eligibility Criteria:
Inclusion Criteria:

* signing the informed consent to participate in the study
* hospitalization due to myocardial infarction
* a mobile device with Internet access and the Android/iOS operating system
* age \>17 years old
* positive results of the test verifying the basic skills of using mobile applications
A Survey of Complementary and Conventional Medicine Use Patterns in the Veteran Population

In this protocol, the investigators proposed to assess the Complementary Alternative Medicine (CAM) usage patterns in a Veteran population using a CAM survey developed by Dr. Hernandez and colleagues. This survey, the Complementary, Alternative and Conventional Medicines Attitudes Scale (CACMAS), is a brief, self-report questionnaire that assesses medical use patterns, as well as attitudes about medical treatment and the relationship among these. The CACMAS will assess the potential role of individual beliefs and attitudes towards complementary and conventional medicine usage patterns, and possibly indicate how this scale might be used to predict optimal treatment offerings for a particular population given attitudes about medical treatments.

The use of complementary and alternative medicine (CAM) in the United States has seen a steady and steep rise over the past two decades. A national survey of over 31,000 adults found that 36% of respondents had used CAM therapies in the last month, and this estimate increased to 62% when prayer for health reasons was included. Second, this same survey showed that CAM is often used to treat symptoms and illnesses associated with stress such as depression, anxiety, back and neck pain, and gastrointestinal disorders. Finally, many individuals experiencing high levels of stress lack access to conventional medicine due to lack of medical insurance, possibly increasing the attractiveness of CAM for these individuals. This ongoing systematic characterization of CAM usage patterns in civilian populations has not been mirrored in active military and military Veteran populations across the United States. Data from the less than handful of studies that have been conducted thus far, suggest that CAM usage patterns in military and military Veteran populations are influenced by demographics and certain medical conditions, as well as dissatisfaction with certain aspects of conventional care. While there appears to be some similarity between civilian and non-civilians populations, there remains much to be known in the latter population.

Eligibility Criteria:
Inclusion Criteria:

* Between ages of 18 and 89
* Currently eligible or receiving health care at a VA Medical Center

Exclusion Criteria:

* Inability to provide informed consent
* Inability to answer comprehension questions
Binocular Amblyopia Treatment

To evaluate the effectiveness of enhanced binocular amblyopia treatments in achieving a more complete and stable recovery.

To date, all studies of contrast-rebalanced binocular amblyopia treatment games used the same 10% per day contrast-increment that was designed for short-term intervention studies lasting 1-4 weeks; i.e., after 18 days of successful game play, both eyes viewed 100% contrast (no contrast-rebalancing).This study will investigate two alternative protocols designed to extend the game treatment period beyond 4 weeks to allow for more complete recovery of visual acuity. The new protocols will be compared with the original 10% contrast-increment game protocol in an 8-week 3-arm RCT to determine whether one or both of the new protocols is more effective than the current 10% increment.

Based on pilot data, we expect about 40% of amblyopic children to achieve normal visual acuity in 8 weeks. In an effort to also promote recovery of binocular vision, children who attain ≤0.4 logMAR at 8 weeks will be enrolled in stereoacuity training at the 8-week visit for the next 4 weeks. Children with residual amblyopia (BCVA \>0.4 logMAR) at the 8-week visit will be provided with dichoptic movies for additional amblyopia treatment for another 4 weeks.

Eligibility Criteria:
Inclusion Criteria:

* age 4-10 y
* male and female
* strabismic, anisometropic, or combined mechanism amblyopia
* amblyopic eye best-corrected visual acuity 0.3-0.8 logMAR
* fellow eye best-corrected visual acuity ≤0.1 logMAR
* interocular visual acuity difference ≥0.3 logMAR
* wearing glasses (if needed) for 8 weeks or no change visual acuity with glasses at 2 visits

  * 4 weeks apart.
* child's ophthalmologist and family must be willing to forgo patching treatment during the 12-week study period
* parent's informed consent
* child must demonstrate understanding and ability to play binocular games

Exclusion Criteria:

* prematurity ≥8 weeks
* coexisting ocular or systemic disease
* developmental delay
* strabismus \>5pd
* any binocular amblyopia treatment in the past 3 months
Effectiveness of a School-Based Hand Sanitizer Program on Reducing Asthma Exacerbations

Asthma is a common, serious illness among children in the United States. Improving hand cleanliness and hygiene may prevent the spread of viruses that can cause asthma exacerbations. This study will evaluate the effectiveness of a school-based hand sanitizer program at reducing the frequency of exacerbations in children with asthma.

In the United States, almost 9 million children have been diagnosed with asthma. It is a leading cause of hospitalizations and school absenteeism among children. Asthma symptoms are often seasonal, with the greatest number of exacerbations occurring in autumn and the fewest in mid-summer. Elementary school children are the most vulnerable to these seasonal changes, and many children experience an increase in exacerbations at the beginning of the school year. Recent research suggests that this seasonal peak in exacerbations is primarily caused by viral respiratory tract infections that are spread among children in school. Regular handwashing has been widely recognized as the most effective way to stop the spread of viruses and infectious illnesses. However, effective handwashing methods among school-age children can be inconsistent. Time constraints, a frequent lack of soap and towels, inconveniently located sinks, and water-saving faucets are all barriers to thorough handwashing. Improving hand hygiene through the use of antimicrobial rinse-free hand sanitizers in school classrooms may be a simple and effective way to reduce the risk of transmitting viruses that can cause asthma exacerbations. The purpose of this study is to evaluate the effectiveness of a school-based hand sanitizer program at decreasing exacerbations in children with asthma.

This study will enroll children with asthma who are attending one of the 32 participating schools. Each school will be randomly assigned to either use their usual hand hygiene practices in Year 1, followed by a two-step hand hygiene program including hand washing plus hand sanitizer in Year 2, or vice versa. Each participant will log in to an Internet-based data collection system on a daily basis to document their asthma symptoms and peak flow meter readings. Teachers will also log in daily to verify participants' data and to document participants' absences and the reason for the absence. Quick relief medication use will be recorded and measured through the use of a Doser device on participants' inhalers.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with asthma
* Enrolled in a participating elementary school