cyrilzakka/clinical-trials huggingface dataset:
Effect of Combining Yoga to TENS on Diabetic Glaucoma

Intraocular pressure (IOP) is maintained by a balance between aqueous production and outflow with an imbalance leading to elevated eye pressure. Very high levels of IOP will subject retinal cells to mechanical stress. In addition to mechanical injury, IOP elevation can impair ocular blood flow reducing perfusion pressure to retinal neurons. Long-term vascular and mechanical stresses can produce further injury at the optic nerve.

Elevated intraocular pressure (IOP) or ocular hypertension (OHT) is the only well-established modifiable risk factor for primary open-angle glaucoma (POAG), the most common form of glaucoma. Glaucoma is a class of optic neuropathy. It is main leading cause of blindness.

Glaucoma is classified on the basis of anatomic features as open angle (where the anterior chamber angle of the eye remains open) and angle-closure (with closure of the anterior chamber angle). Glaucoma is considered primary if the eye has no preexisting disease. Secondary forms of glaucoma are caused by various ocular or systemic diseases such as pigment dispersion syndrome and ocular trauma.

It seems reasonable to consider that a longer duration of diabetes mellitus (DM) with a prolonged insult to the retina and optic nerve via vascular, glial, and neuronal factors would be associated with a higher risk of OAG.

patients with diabetic glaucoma (80 patients ) from both sexes will be divided to 2 groups, 40 patients for each group;

study group will receive only one session of 20 minutes yoga ocular training for 20 minutes followed by transcutaneous electrical nerve stimulation (TENS) by placing electrodes on skin over urinary bladder (BL) acupoints 61 and 62 for 20 minutes

control group will be treated with the same protocol as the study group but with the TENS unit is off.

Eligibility Criteria:
Inclusion Criteria:

* Patients with DM duration more than 5 years .
* BMI will be \< 30 kg/m² .
* patients with bilateral primary open-angle glaucoma.

Exclusion Criteria:

* acute or chronic eye inflammation
* cataract
* eye surgeries
* mental ill patients
* patients who will refuse to participate in the study
The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.


Eligibility Criteria:
Inclusion Criteria:

* patients with glaucoma with a trabeculectomy required
* 60 eyes of 60 patients, The ratio of female / male is not involved.
* Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).
* age of at least 18 years

Exclusion Criteria:

* all patients not included in the group of inclusion criteria.
* less than 50yl anterior chamber fluid could be collected during the operation.
Unmet Health Needs Among Students

The concept of unmet health needs refers to the difference between health services thought necessary to treat a particular health problem and services actually received. A person who perceived the need to receive medical services but who has not obtained these services has unmet health care needs. Unmet health care may result from limited availability or unavailability of health care services, when or where they were required. Also it can be caused from individual accessibility problem, such as cost or transportation, or from acceptability problem, such as attitude toward and knowledge about health care.so, the investigators will assess the unmet health needs and identify the causes.


Eligibility Criteria:
Inclusion Criteria:

* all students who are more than 18 years old and approve to participate in the study

Exclusion Criteria:

* any students who refuse to participate in the study or who are under 18 years old
CTEPH Identification an Standard Computerised Tomography Pulmonary Angiography in Pulmonary Embolism Patients

In this study the investigators will evaluate whether more careful reading (than the current standard) of routine computerised tomography pulmonary angiography (CTPA) performed in the clinical work-up of suspected (pulmonary embolism (PE) will differentiate patients with acute PE from those with more chronic or acute on chronic PE, which could be indicative of the presence of chronic thromboembolic pulmonary hypertension (CTEPH)"

The investigators will study 50 consecutive patients diagnosed with CTEPH as well as 50 patients diagnosed with acute PE in whom CTEPH was ruled out 2 years after the PE diagnosis by sequential echocardiography. The cases and controls will be matched based on the right-to-left ventrilcle diameter ratio.

Three experienced thorax radiologists with specific expertise on acute PE and CTEPH will blindly assess the index CTPAs of the study population. In addition to the binominal judgement whether CTEPH signs are already present (or not), the presence of the following items will be scored by all 3 readers independently:

* Webs or bands
* Residual thrombus attached to the vascular wall
* Complete occlusion /retraction
* Mosaic perfusion
* Pulmonary infarct
* Parenchymal bands
* Bronchial arteries
* Right atrial (RA) dilatation
* Right ventricle (RV) dilatation
* Flattening of the septum
* Right ventricle (RV) hypertrophy
* Dilated truncus pulmonalis
* Cardiac signs of pulmonary hypertension (PH)
* Further remarks (free text)

Eligibility Criteria:
Inclusion Criteria:

* patients after an acute PE diagnosed with CTEPH according to current guidelines, patients after an acute PE in whom CTEPH is excluded by follow-up echocardiography
* availability of the CTPA scan of the initial PE episode

Exclusion Criteria:

* CTEPH diagnosis based on other test results than a RHC
* Patients who did not receive anticoagulation after PE diagnosis
* Patients under the age of 18 years old
* Patients in the control group with a follow-up duration of less than 2 years after the index PE episode
* Use of a CTPA scanner with less than 32-detector rows
Persistent Cervical HPV Infection With Clearance and Vaginal Microbiota

Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the persistence infection and clearance of HPV infection.

Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. Additional factors correlated with HPV persistence include immunodeficiency caused by HIV, smoking, use of oral contraceptives and, more recently reported, vaginal dysbiosis. In a state of dysbiosis, there is a marked reduction of Lactobacillus and a high diversity of bacteria, with increased abundance of anaerobic bacterial species. High-risk HPV cervical infections are common in young, sexually active women. Most of these infections are transient and do not cause clinical symptoms. After 12-30 months of HPV infection, 70-90% of patients can be cleared naturally, but there are still a small number of patients with high-risk HPV infection can not be eliminated by itself and continue to infect, and can develop into cervical intraepithelial neoplasia, eventually progressing to invasive cervical cancer. Persistent infection of high-risk HPV is a necessary condition for the occurrence of cervical cancer and precancerous lesions. Early blocking of persistent infection of high-risk HPV and timely treatment of cervical precancerous lesions are of great significance in preventing the occurrence of cervical cancer. This project intends to study the relationship between vaginal microbial composition and persistent HPV infection, and determine the related strains and their molecular mechanisms, so as to provide new ideas and basis for its treatment.

Eligibility Criteria:
Inclusion Criteria:

* Those are aged 20 to 45 years old, have had vaginal intercourse more than 3 years, and aren't in menstrual, pregnancy or puerperium period.

Exclusion Criteria:

* Those have no vaginal intercourse, and can't cooperate the examiner. Women who are HIV or hepatitis B/C positive, have autoimmune disorders and systemic disease (like diabetes mellitus, hormone treatment diseases, severe liver and kidney dysfunction), or have severe mental illness and malignant tumors are also excluded. At the same time, all the participants should meet the following requirements: no vagina douching within last 2 days, no vaginal intercourse within last 3 days, no systemic application of antifungal agents or antibiotics or pessaries within last 14 days of sampling.
Treatment With TNF Blockade, Infliximab, in Patients With Myositis

This is a 4 month open trial with TNF-blockade using infliximab (an antibody that blocks TNF) in adult patients with chronic myositis (polymyositis, dermatomyositis, inclusion body myositis) who have persisting muscle weakness and inflammatory active disease despite adequate treatment with immunosuppressives either currently or previously.

Infliximab is given as infusions, 5 mg/kg body weight, these infusions are repeated after 2, 6 and 14 weeks. The study involves 15 adult patients.

Primary outcome measure is muscle function assessed by muscle function index score.

Other outcome measures are Myositis Disease Activity core set: Patient's global assessment and physicians global assessment on visual analogue scales (VAS). Manual muscle test, Health assessment questionnaire (HAQ), serum levels of CPK, LD and extra muscular disease activity score. Muscle biopsy, Magnetic resonance imaging (MRI) of thigh muscles and Health related Quality of life, measured by SF-36.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients.
* Persisting muscle weakness defined as ≤ 80% of muscle strength as measured by functional index of myositis
* Signs of disease activity defined as muscle edema observed by magnetic resonance imaging (MRI) or creatine kinase (CK) elevation, or inflammatory cell infiltrates on muscle biopsy, and failure to respond to treatment with glucocorticoids for a minimum of six months in combination with azathioprine or methotrexate.

Exclusion Criteria:

* Pregnant women, nursing mothers or a planned pregnancy within one and a half years of enrolment.
* Prior administration of infliximab or any other therapeutic agent targeted at reducing TNF (e.g., Etanercept, pentoxifylline, thalidomide or anti-CD4+ antibody) within the previous six months.
* A history of known allergies to murine proteins.
* Serious infections, such as hepatitis, pneumonia, pyelonephritis in the previous 3 months. Less serious infections in the previous 3 months, such as acute upper respiratory tract infection (colds) or uncomplicated urinary tract infection (colds) or uncomplicated urinary tract infection need not to considered exclusions at the discretion of the treating physician.
* History of opportunistic infections such as herpes zoster within 2 months of screening. Evidence of active CMV, active pneumocystis carinii, drug resistant atypical mycobacterium, etc.
* Documented HIV infection.
* Current signs or symptoms of severe, progressive or uncontrolled renal, hepatic, hematologic, endocrine, pulmonary, cardiac, neurologic or cerebral disease.
* Any currently known malignancy or pre-malignant lesions or any history of malignancy within the past five years.
* Patients with alcoholism, alcoholic liver disease, or other chronic liver disease.
* Patients with a positive PPD and chest X-Ray suggestive of active TB or a previous exposure to TB.
Change i Perceived Stress in School-age Students When Adding Physiotherapists to a School's Health Team.

School stress and performance requirements have been shown to contribute to mental illness among children and young people.

Student health teams have an important role regarding mental health of children and young people. Swedish student health teams include various health and pedagogical professionals, but physiotherapists are uncommon, despite the good effects school-related physical activity interventions have had on reducing anxiety and improving well-being in children and young people.

Haga School, Dals-Ed has now employed physiotherapists as part of the student health team to support students in learning to define, reduce and manage stress.

The purpose of the research project is to investigate changes in perceived stress level and stress-related symptoms, as well as study results and absence from school during two years for students in grades 4 to 9 at Haga School. A questionnaire will be sent out on four occasions over two years. Group level statistics on study results and school absence will be compared with years previous to the introduction of the school physiotherapist. The research contributes to increased knowledge about effects of having a physiotherapist as part of a student health team in Sweden.

School stress and performance requirements have been shown to contribute to mental illness among children and young people.

Student health teams have an important role regarding mental health of children and young people. Swedish student health teams include various health and pedagogical professionals, but physiotherapists are uncommon, despite the good effects school-related physical activity interventions have had on reducing anxiety and improving well-being in children and young people.

Haga School, Dals-Ed has now employed physiotherapists as part of the student health team to support students in learning to define, reduce and manage stress.

The purpose of the research project is to investigate changes in perceived stress level and stress-related symptoms, as well as study results and absence from school during two years for students in grades 4 to 9 at Haga School. A questionnaire will be sent out on four occasions over two years. Group level statistics on study results and school absence will be compared with years previous to the introduction of the school physiotherapist. The research contributes to increased knowledge about effects of having a physiotherapist as part of a student health team in Sweden.

Eligibility Criteria:
Inclusion Criteria:

* Registered students in grades 4-9 at Haga School in Dals-Ed, Sweden

Exclusion Criteria:

* None
Benchmarking the iOS Balance Application Against the Berg Balance Test

This study aims to benchmark the performance of an iOS application against the Berg Balance Scale (BBS), which is the most commonly used assessment tool by clinicians for measuring balance across the continuum from acute care to community-based care. An iPhone will be tied around the waist of the participant and concurrent measurements will be taken for five of the fourteen stances which comprise the BBS.

'Project Balance' aims to make balance an actionable component of an individuals health, allowing a long term intervention via a monitoring and training of balance health much before a fall happens. Towards this end, we have designed an iOS application and a belt. The phone is kept stable against the lower back of the participant using the belt. The application turns on the accelerometer in the phone to sample acceleration along x (media lateral) and z (anterior posterior) axis. These displacements from the mean are used to calculate the Root Mean Square of a person which acts a proxy score for Postural Sway. (Postural sway is defined as the phenomenon of constant displacement and correction of the position of the center of gravity within the base of support)

Studies in the past have compared the use of accelerometers to the use of the clinical measured of Timed Up (TUG) test and Berg Balance Scale (BBS) in the assessment of postural stability and indicated that there is a high correlation between BBS, TUG and Accelerometry. Accelerometry has also found to be able to distinguish between sway responses to differing balancing conditions and between fallers and non-fallers.

We aim to conduct a benchmarking study for our iOS application against the BBS.

Eligibility Criteria:
Inclusion Criteria:

Between the ages of 18 - 69 Selected to undergo a Berg Balance Sale Impairments including : Ankle injures, Knee Replacements, Hip Replacements, Knee injuries, ligament tears etc.

Exclusion Criteria:

Subjects will be excluded from participation if they have peripheral neuropathy (clinically diagnosed or if they had symptoms of numbness/tingling in the lower extremities); pain of any level presenting simultaneously in both lower extremities; or unilateral lower extremity pain \>3 on the 11 point visual analog (box) scale. Pregnant women will be excluded.
CP-675,206 in Combination With Short Term Androgen Deprivation in Patients With Stage D0 Prostate Cancer

The current protocol will evaluate the safety of combining treatment with bicalutamide(Casodex) and CP-675,206 (anti-CTLA-4 monoclonal antibody) in patients with PSA-recurrent non-metastatic (stage D0) prostate cancer. This is a dose escalation study with safety the primary endpoint. Secondary endpoints will be to determine whether prostate associated immune responses are seen, and whether treatment is associated with an increase in PSA doubling time and PSA recurrence at one year, as markers of clinical activity. Cohorts of six patients will be treated in each dose level. The investigators hypothesize that short-term androgen deprivation therapy will elicit prostate cancer-associated T-cell mediated tissue destruction that can be augmented with a monoclonal antibody blocking CTLA-4, and that this will have therapeutic benefit in patients with recurrent prostate cancer.

This is an open label, single-center Phase I study. All subjects will receive bicalutamide 150mg orally days 1-28. Subjects will receive CP-675,206 IV over one hour on day 29. Doses will range from 6 mg/kg to 15 mg/kg. This cycle will be repeated once at month 3. Once the maximum tolerated dose has been determined, up to 6 additional subjects will be enrolled.

Eligibility Criteria:
Inclusion Criteria:

* At least 18 years of age \& histologic diagnosis of adenocarcinoma of the prostate
* Completed surgery or radiation at least 8 weeks prior to entry with removal of all visible disease
* Clinical Stage D0 prostate cancer with rising PSA and PSA \>2ng/ml.
* ECOG performance of \<2
* Normal hematologic, renal and liver function

Exclusion Criteria:

* Cannot have evidence of immunosuppression or have been treated with immunosuppressive therapy.
* No prior treatment with an LHRH agonist or nonsteroidal antiandrogen such as casodex or flutamide
* No evidence for metastatic disease per bone scan or CT scan of the abdomen and pelvis
* No prior treatment with anti-CTLA 4 monoclonal antibody
* No history of known autoimmune disorder or HIV, hepatitis B or hepatitis C
* No known brain metastases
* No history of inflammatory bowel conditions including diverticulitis, ulcerative colitis, etc.
Magnetic Field Therapy Versus Transcutaneous Electrical Nerve-stimulation in Knee Osteoarthritis

The effectiveness of PEMF in improving physical function among Osteoarthritic (OA) patients remains a topic of debate, leading to the American College of Rheumatology not yet endorsing its use in OA treatment. Therefore, it's essential to investigate PEMF therapy's efficacy in alleviating joint pain, stiffness, and enhancing physical function in knee OA patients Our study objectives were to evaluate the effectiveness and safety of PEMF therapy and to compare its efficacy with TENS in knee OA management.


Eligibility Criteria:
Inclusion Criteria:

* We included patients who had knee pain due to knee OA diagnosed according to the American College of Rheumatology including:
* Knee pain AND presence of at least three of the following 6 criteria:

  * Age \> 50 years
  * Morning stiffness \< 30 minutes
  * Crepitus during movement
  * Periarticular bone pain
  * Periarticular bone hypertrophy
  * Absence of increased local warmth.

Exclusion Criteria:

* For both groups, we did not include:

  * Patients with a pacemaker, implantable defibrillator, cochlear implant, or any metal implant contraindicating MRI (knee prosthesis, hip prosthesis, etc.).
  * Pregnant women
  * Patients with an active infection
  * Profound hypoesthesia or thermoalgic sensitivity disorder
  * Poorly vascularized areas: arteritis, phlebitis, ischemia
  * Patients on anti-vitamin K treatment or with a coagulation disorder. Patients with long-term corticosteroid therapy or having a total knee replacement, those who have received therapies for knee osteoarthritis including intra-articular corticosteroid injection or viscosupplementation in the last 4 months, and Patients with knee pain of non-osteoarthritic origin were also not included in the study.
The Effect of Cold Exposure on Glucose Tolerance

The purpose of the study is to evaluate the effect of cold exposure on an individual's glucose tolerance. Previous research has already shown that 10 days acclimation to a mild cold environment (14-15°C) can enhance insulin sensitivity. However, the duration in the cold environment was 6 hours per day which may not be practical for everyone. Therefore, the present study will investigate the effect of a shorter, and more intense cold exposure on an individual's glucose tolerance. It is hypothesised that cold exposure before consuming a glucose drink will enhance glucose clearance.


Eligibility Criteria:
Inclusion Criteria of healthy population:

* Signed informed consent.
* White European.
* Male.
* Age 18 - 40 years at the start of the study.
* BMI ≥ 20 and \< 30 kg/m2.

Exclusion Criteria of healthy population:

* Smoking.
* Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other).
* Cold-acclimated (takes daily cold baths, works in a refrigerated environment, or regular cold water swimmer).
* Unstable body weight (gain or loss \> 5kg in last 3 months).
* Currently undertaking a diet.

Inclusion Criteria of prediabetes population:

* Signed informed consent.
* White European.
* Male or female.
* Women should be postmenopausal or use hormonal contraceptives.
* Age 30 - 75 years at the start of the study.
* BMI ≥ 25 and \< 35 kg/m2.
* Generally healthy, no medication use that interferes with metabolism. If volunteers need medication (e.g. statin drugs, NSAIDs), it will be reviewed with the dependent physician on an individual basis.
* Impaired fasting glucose (5.6 mM to 6.9 mM) and/or blood glucose values 7.8-11.0 mM 2h after glucose drink consumption during OGTT in screening.

Exclusion Criteria of prediabetes population:

* Smoking.
* Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other).
* Cold-acclimated (takes daily cold baths, works in a refrigerated environment, or regular cold water swimmer).
* Unstable body weight (gain or loss \> 5kg in last 3 months).
* Currently undertaking a diet.