cyrilzakka/clinical-trials huggingface dataset:
Use of TENS in Non-surgical Periodontal Treatment

the aim of the study is to verify the use of TENS in non-surgical periodontal therapy in order to relief pain

non-surgical periodontal therapy could be painfull for some patients and the pain that they may experience can let them avoid therapies, with huge risks for their oral health. Transcutaneous electrical neurostimulation (TENS) is a device largely used in temporomandibular disorders in order to reduce pain. The aim of our study is to analyze the effect of Transcutaneous electrical neurostimulation (TENS) at the tragus during non-surgical periodontal therapy fro pain relief

Eligibility Criteria:
Inclusion Criteria:

* Patients aging more than 18 and of both sexes seeking for non-surgical periodontal treatment

Exclusion Criteria:

* Patients following opioids or analgesic therapies during the study

  * Pregnant women
  * Patients who have had episodes of epilepsy
  * Pace-maker patients
  * Patients who did not signed the informed consent to participate in the study.
Preventing Malnutrition Among Older Adults

This project aims to explore whether access to a digital education video can improve the nutritional situation of home-living older adults after being discharged from the hospital.


Eligibility Criteria:
Inclusion Criteria:

* Orthopedic and surgical in bedded patient patients in a selected regional hospital in Norway.
* Over 65 years old. Have their home address in one of nine selected municipalities in Nordland county.
* home living and due to return home after discharge directly from the hospital or after a short-term training stay at a training centre before returning home.
* Could read and understand Norwegian.
* Have consent competence.
* Have a Body mass index less than 24.

Exclusion Criteria:

* Patients patients only receiving liquid diet such as tube feeding
* terminal-ill patients
Preventing Problem Behavior Among Middle School Students

Problem behaviors such as drug use, violence, and school misconduct increase during adolescence. This study evaluated a program designed to prevent problem behaviors in middle school students; the program includes classroom instruction for students and home instruction for parents.

The prevalence of problem behaviors, such as school misconduct, underachievement, and dropout; tobacco, alcohol, and other drug use; and violence and delinquency, increases dramatically during adolescence. These behaviors place youths at an increased risk for school failure, involvement in the criminal justice system, and chronic substance abuse.

The purpose of this study was to test the efficacy of a comprehensive program of interventions, called Going Places, that includes participatory classroom curriculum, parent education, and enhanced school environment. The primary goal of these components was to help students learn social competence skills that will help them make positive decisions in their lives. The classroom curriculum component was integrated into the participating schools' regular Language Arts curriculum in grades 6 through 8. The curriculum provided instruction in and opportunities to practice interpersonal communication, self-management, problem solving, and conflict management. Brief videotapes with student actors served as trigger films to stimulate student interest, provide models, and motivate prosocial behavior. Parents in the participating schools received instruction via videotape and print materials and participated in student homework exercises. The emphasis was on encouraging parents to remain involved, adopt creative monitoring practices, and foster adolescent autonomy by establishing rules and conditions leading incrementally to greater independence.

Students in the seven Charles County, Maryland, middle schools were randomized either to the Going Places intervention group or to the usual education control group. The intervention was sequentially structured, with curricula implemented in each grade of middle school. Questionnaires were administered to all middle school students at the beginning of the 6th grade (before the intervention) to establish baseline levels of substance use, school misconduct, parent and peer influences, and school climate. Students completed surveys in the spring of grades 6, 7, and 8. A final follow-up survey was completed in the fall of ninth grade. The surveys assessed standard measures of tobacco, alcohol, and illicit drug use, school misconduct, and participation in school activities. The surveys also included items related to psychosocial, parental, and school factors.

Eligibility Criteria:
Inclusion Criteria

* Attends participating middle schools
* Reads at grade level
Framingham Cycle V Offspring-Spouse Nutrition Studies

To examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over seven years using the Cycle V Framingham Offspring/Spouse examination ; to examine the cross-sectional associations between dietary variables and major cardiovascular disease risk factors, to examine changes in dietary behaviors and their determinants over seven years; and to characterize the influences of dietary behavior changes on risk factor status between 1984-88 and 1991-94.

DESIGN NARRATIVE:

The data collection efforts and cross-sectional analyses were carried out among approximately 3800 males and females during the scheduled 1991-1994 Cycle V Framingham Offspring/Spouse study. The secular trend and longitudinal analyses also included data that were collected during the Cycle III Offspring/Spouse studies in 1984-88. Of particular interest were dietary variables which play a major role in serum total cholesterol and lipoprotein regulation. Additional dietary variables which were associated with major cardiovascular risk factors ((elevated) blood pressure, glucose (in)tolerance, (excess) body weight or physical (in)activity, and smoking) or that may predict CHD endpoints were included in the analyses. The potential confounding effects or interactions between dietary and risk factor variables were considered. Separate analyses were carried out in males and females.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility Criteria:
No eligibility criteria
Biomarkers in Prehospital Rule-out of Intracranial Lesions in TBI Patients

The PreTBI I study will investigate whether prehospital blood samples drawn already in the ambulance can rule-out intracranial lesions in patients suffering head trauma. The study aims to improve triage and treatment of patients suffering mild head trauma, who are considered low-risk patients. These patients do not always benefit from hospitalization, but are nevertheless admitted on precaution, as clinical assesment can be difficult.

Hypotheses:

1. A prehospital measurement of serum S100B ≤ 0,10 microgram/L in mild TBI patients rules out traumatic intracranial lesion with a sensitivity \>97%.
2. A prehospital measurement of serum GFAP (glial acidic fibrillary protein) in mild TBI patients rules out traumatic intracranial lesion with sensitivity \>97% and results in lower false positive rate than S100B.
3. Prehospital measurements of both GFAP and S100B results in lower false positive rates than in-hospital measurements.


Eligibility Criteria:
Inclusion Criteria:

* Patients presenting with Glasgow Coma Score (GCS) ≥13-15 and a loss of consciousness for less than 30 min and/or alteration of mental state (being dazed, confused or disorientated) and/or loss of memory for events immediately before and/or after the trauma. The emergency medical service staff will be guided through the inclusion and consent procedures by a simple tablet algorithm.

Exclusion Criteria:

* Patients \<18 years, GCS \<13, \>6 hours elapsed after trauma, unknown time of trauma, multi trauma, known dementia, chronic psychosis or active central nervous system pathology.
Cannabis Oil for Chronic Non-Cancer Pain Treatment

Cannabis is being prescribed medically for chronic non-cancer pain despite limited evidence whether or not it works to reduce average pain in patients with chronic non-cancer pain. The cannabis plant (Cannabis sativa, Cannabis indica) consists of several hundred compounds of which, approximately 70 of which are thought to be active. The two active cannabinoids of interest in this trial are tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). The goal of this trial is to determine whether CBD or CBD+THC reduces the average pain in participants with chronic non-cancer pain. The investigators also aim to determine whether CBD or CBD+THC is associated with a reduction in pain severity, pain interference, anxiety, depression, insomnia, opioids and use of benzodiazepines, analgesics, antidepressants, anxiolytics, or hypnotics amongst chronic non-cancer pain patients or an increase in physical functioning, physical health related role limitations, social functioning, mental functioning.


Eligibility Criteria:
Inclusion Criteria:

* Age \>25
* Average pain score in past week of ≥ 4/10.

Exclusion Criteria:

* Personal history of bipolar disorder
* Personal or family history (first degree relative - parent of sibling) of psychotic disorders (e.g., schizophrenia)
* Active cancer (an individual undergoing active cancer chemotherapy, radiation or surgical treatment and is deemed to not be in remission as per an oncologist's report)
* Intention to travel internationally during the trial
* Uncontrolled diabetes (A1C \> 11)
* Cannabis use in the past 4 weeks (recreational or medicinal)
* Current use of illicit drugs (e.g., cocaine)
* Current use of non-prescription opioids
* Unable to read and write in English
* Women who are currently pregnant or breast-feeding; or women of child-bearing age who plan to become pregnant during the trial period.
Effect Of High Magnification On Quality Of Life And Success After Endodontic Microsurgery: A Randomized Controlled Trial

Effect of high magnification on quality of life and success after endodontic surgery: a randomized controlled trial"

: Residual infection in untreated canal space is one of the most common cause of post treatment apical periodontitis. The prevalence of post treatment apical periodontitis has been reported to be 60% to 80%. Endodontic microsurgery and root resection removes the inaccessible apical ramifications and ensures adequate sealing of apical communication. Magnification has been recommended for better visualization of apical terminus. Various case reports and retrospective studies have reported higher success of apical surgery when magnification devices have been used as an adjunct to periapical surgery (setzer 2010, tsesis 2006, bud 2020). However, there are very few prospective studies and there is heterogeneity in data in terms of type of magnification used and there are very few studies comparing different magnification devices.

To the best of our knowledge no randomized controlled trial has been done on the periapical surgery of maxillary anterior teeth which compares the effect of magnification by microscope versus loupes, hence the aim of this study is to assess the quality of life and success after endodontic surgery using with or without magnification.

Eligibility Criteria:
Inclusion Criteria:

* Patients between age of 18-55 with the diagnosis of persistent symptomatic apical periodontitis in previously treated teeth with radiographic evidence of periapical radiolucency (≥ 5 mm). (Bharathi et al 2021) Tooth with a peri radicular lesion of strictly endodontic origin and unrestorable by nonsurgical retreatment. ASA-1 patients according to the classification of the American Society of Anesthesiologists).

Exclusion Criteria:

Patients with systemic diseases (diabetes mellitus, uncontrolled hypertension grade III, hepatic/renal disease, or systemic bleeding disorders) Combined endodontic-periodontic lesions Pregnancy

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Ultrasound Comparison of the Surface of the Subclavian and the Axillary Vein Versus the Surface of the Subclavian Vein

The main objective of this study is the demonstration of an increase of over 50% of the surface visible on ultrasound (mm2) of the axillary vein and subclavian vein in arm abduction (90 °) and external rotation (90 °) with respect to the surface of the subclavian vein along the arm body.

The secondary objective of this study is to investigate the anatomical relationships of these veins with the subclavian artery, the brachial plexus and the pleura, and assess the depth of the vein to the skin. Specifically, the following will be assessed:

* the depth of the vein (mm)
* the length of the minor axis (mm)
* the length of the major axis (mm)
* artery-vein distance (mm)
* vein-pleural distance (mm)
* the distance of the brachial plexus (mm)

Eligibility Criteria:
Inclusion Criteria:

* The volunteer must have given his/her informed and signed consent
* The volunteer must be insured or beneficiary of a health insurance plan
* The volunteer is 18 to 50 years old

Exclusion Criteria:

* The volunteer is participating in another study
* The volunteer is in an exclusion period determined by a previous study
* The volunteer is under judicial protection, under tutorship or curatorship
* The volunteer refuses to sign the consent
* It is impossible to correctly inform the volunteer
* The volunteer is pregnant, parturient, or breastfeeding
* The volunteer has a contraindication for the exams in this study
* Volunteer with a history of trauma or surgery in the axilla or the shoulder girdle
* Volunteer with a known history of venous thrombosis in the axillary and / or subclavian veins
Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal

Severe acute pancreatitis (SAP) has a mortality of up to 42%. The outcome of SAP is related to the development of SIRS and consecutive organ failures. Due to the lack of a causative therapy except the removal of bile duct stones, therapy is predominantly symptomatic.

With regard to a marked inflammatory response ("cytokine storm") during the early phase of SAP extracorporeal cytokine removal is a promising therapeutic approach.

This prospective case control study investigates the impact of early extracorporeal cytokine adsorption with the CytoSorb®-device on haemodynamics (primary endpoint) and several secondary outcomes.

Severe acute pancreatitis (SAP) has a mortality of up to 42%. The outcome of SAP is related to the development of SIRS and consecutive organ failures. Due to the lack of a causative therapy except the removal of bile duct stones, therapy is predominantly symptomatic.

Severity and mortality are associated to an early systemic inflammatory response syndrome (SIRS) and to septic complications at a later stage of disease.

With regard to a marked inflammatory response ("cytokine storm") during the early phase of SAP extracorporeal cytokine removal is a promising therapeutic approach.

This prospective case control study investigates the impact of early extracorporeal cytokine adsorption with the CytoSorb® device on haemodynamics (primary endpoint) and several secondary outcomes.

Patients with high probability of SAP (APACHE-II-score ≥10) are eligible for 7 days after the onset of pain.

The patients will be treated for 48h with two consecutive 24h sessions of cytokine absorption with the CytoSorb®-device.

All patients will be under haemodynamic Monitoring with transpulmonary thermodilution The primary endpoint is defined as an improvement of the vasopressor dependency index of ≥20% (if no vasoactive drugs are used at baseline, the cardiac power index cardiac power index (CPI) will be used as primary endpoint).

The outcome analysis will be based on comparison of the incidence of the primary endpoint in 30 Intervention patients compared to 60 matched controls.

Eligibility Criteria:
Inclusion Criteria:

* Proven acute pancreatitis:

  * typical pain
  * at least 3-fold increase in serum lipase
  * onset of pain within 7 days before inclusion AND
* APACHE-II ≥10 AND
* ≥1 criterion of "severe sepsis" AND
* Haemodynamic monitoring with transpulmonary thermodilution AND
* ≥ 1 marker of poor prognosis of acute pancreatitis:

  * Haematocrit \> 44% (men), \>40% (women)
  * Blood glucose \> 125 mg/dL
  * C-reactive protein (CRP) \> 10mg/dL
  * Computed tomography score category C-E
  * Age \>55 years
  * Leukocytes \>16 G/L
  * Glutamate oxaloacetate transferase (GOT) \>250 U/L
  * Lactate dehydrogenase (LDH) \>350 U/L
  * Calcium \<2,0mmol/L

Exclusion Criteria:

* pregnancy
* lack of informed consent of patient or representative
* pre-existing disease with life expectancy \<3 months
Active aGeing And Personalised Service's Ecosystem (AGAPE) Aims to Implement an Advanced Technology Platform That Provides Services to the Elderly, Formal and Informal Caregivers, and Caregiving Organizations

AGAPE aims to implement an advanced technology platform that provides services to older adults, formal and informal caregivers, and caregiving organizations.

AGAPE aims to promote an active and healthy lifestyle in the over-65 population and, in parallel, to improve the quality of life of caregivers (by reducing the burden of care), while also overcoming the possible digital literacy gap of users. The advantage of the AGAPE platform is to offer users highly personalized services based on their needs and digital capabilities, and innovative technologies integrated with each other that fit within the spatial services already available in local ecosystems. The project involves an impact-by-design approach that engages older people, caregivers, and managers of care organizations in a co-creation strategy. In addition, the solutions offered by the AGAPE platform will be extensively tested in a preliminary pre-validation phase in order to effectively meet the needs of end users.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 65 years
* Ability to understand the rationale and characteristics of the study and to provide informed consent
* Low level of frailty, indicated by a score \<5 on the Rockwood Clinical Frailty Scale (Rockwood et al., 2005)
* Absence of moderate to severe cognitive impairment, indicated by a Mini-Mental State Examination (MMSE) score ≥ 24 (adjusted score; Folstein, 1975)
* Absence of severe comorbidities and clinically relevant diseases

Exclusion Criteria:

* Age below 65 years
* Inability to provide informed consent for participation in the study
* High level of frailty (Rockwood Clinical Frailty Scale \> 5)
* Presence of cognitive impairment (adjusted MMSE score \< 24)
* Diagnosed anxiety and depression
* Presence of severe disability and serious health conditions
Surgical Trial Comparing LIGASURE Assisted Recto-Sigmoid Resection and Omentectomy Compared to Stand

The objective of this prospective randomized surgical trial is to evaluate whether the use of the LIGASURE surgical device during omentectomy and/or recto-sigmoid resection for women with ovarian cancer will reduce the surgical time compared to standard surgical resection using clamps and surgical ligatures.

This research study is a prospective, randomized trial. Women who are suspected to have an early or late stage ovarian cancer during their preoperative evaluation will be potential study participants. Only patients with documented ovarian cancer by histologic examination at the time of the cytoreductive or staging surgery, and that are also undergoing omentectomy and/or recto-sigmoid colon resection will be eligible for participation. Patients who are eligible for participation and who are willing to participate will be randomized during the surgical procedure to standard surgical resection using clamps and surgical ligatures versus resection using the FDA-approved LIGASURE device during omentectomy and resection of the recto-sigmoid portion of the colon. The resection of these tissues will be performed as part of the usual surgical protocol for women with ovarian cancer and will not be done so unless the tissues are the sites of metastatic disease or if their removal would be performed for staging purposes.

Eligibility Criteria:
Inclusion Criteria:

* Patients must be 18 years or older
* All patients who are suspected to have an early or late stage ovarian cancer during their preoperative evaluation will be potential study participants.
* Potential candidates must have signed an IRB-approved Informed Consent (University of Utah Informed consent if their surgery will be performed at the Huntsman Cancer Hospital, or Intermountain Health Care consent if the surgery is to be performed at LDSH or IMC.
* Only patients with documented ovarian cancer by histologic examination at the time of the cytoreductive or staging surgery, and that are also undergoing omentectomy and/or recto-sigmoid colon resection will be eligible for participation.

Exclusion Criteria:

* none
The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients

The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients.

The study hypothesizes that the electrical impedence tomography (EIT) measured the changes of end expiratory lung impedence (△EELI） could accurately predict the changes of end expiratory lung volume （△EELV） measured by passive expiratory in controlled mechanical ventilated exacerbation COPD patients. The research intended to conduct a research to explore the relationship between △EELI and △EELV induced by external PEEP changes in ventilated exacerbation COPD patients.

Eligibility Criteria:
Inclusion Criteria:

* 2022.7-2023.1 exacerbation COPD invasive ventilated patients admitted to the first affiliated Guangzhou medical university; 35 to 80 years old; in stable condition judged by clinicians

Exclusion Criteria:

* SpO2\<88%; instable hemodynamic (MAP\<65mmHg；Norepinephrine\> 0.1ug/kg.min); pregnancy; 4 hour intravenous diuretics use before research; chest deformity and trauma, subpleural pulmonary bulla; implanted electronic devices(cardiac pacemaker, implantable cardioversion defibrillator,ect); tumour or other organ dysfunction; refuse to signature the informed consent