cyrilzakka/clinical-trials huggingface dataset:
Echocardiographic Standards and Sub-Saharian Africans (SSA) Migrants' in New Aquitaine Region

Standards Echocardiographic have been defined mainly on caucasian or Asian populations. In the EchoNoRMAL study the criteria for African populations were based solely on data from 198 subjects. This study suggests the presence of different standards depending on the ethnic origin of the subjects. The aims of this study is to describe the proportion of subjects reclassified (normal-pathological) according to the use of echocardiographic norm differences showed in TAHES population (Sub Saharian Africans) with those routinely used

Sub-Saharian Africans populations seem to be more vulnerable in the field of health in general and in cardiovascular pathologies in particular.

* The echocardiographic standards were mainly defined for Caucasian or Asian populations (EchoNoRMAL col. 2014 and 2015). In the EchoNoRMAL study, the criteria for the African populations were based on a reduced workforce (data from 198 subjects).
* This study suggests the presence of different standards depending on the ethnic origin of the subjects. The authors noted that the establishment of references according to the ethnic origin of the subjects is necessary and highlighted the need for additional study for the underrepresented groups, in particular those including subjects of African origin.

The need for different ECG standards in African subjects, was confirmed in a study in the general African population (TAHES), represents 16% of immigrants in 2015 (INSEE According to reports from the health insurance funds, the migrant population,

Eligibility Criteria:
Inclusion Criteria:

- SSA Major Subjects (first generation or from or from first generation parents) admitted to the hospital for an echocardiography

Exclusion Criteria:

* Participation refusal;
* Any acute heart disease (endocarditis, myocarditis, coronary syndrome);
* Valvulopathy justifying an intervention;
* Diseases of overload.
* Any acute heart disease (endocarditis, myocarditis, coronary syndrome);
* Valvulopathy justifying an intervention;
* Diseases of overload.
* Both participant and accompanying person unable to understand the information note written in French and in English
Hot Water Immersion as a Heat Acclimation Strategy in Older Adults

Aging is associated with impairments in heat loss responses of skin blood flow and sweating leading to reductions in whole-body heat loss. Consequently, older adults store more body heat and experience greater elevations in core temperature during heat exposure at rest and during exercise. This maladaptive response occurs in adults as young as 40 years of age. Recently, heat acclimation associated with repeated bouts of exercise in the heat performed over 7 successive days has been shown to enhance whole-body heat loss in older adults, leading to a reduction in body heat storage. However, performing exercise in the heat may not be well tolerated or feasible for many older adults. Passive heat acclimation, such as the use of warm-water immersion may be an effective, alternative method to enhance heat-loss capacity in older adults. Thus, the following study aims to assess the effectiveness of a 7-day warm-water immersion (\~40°C) protocol in enhancing whole-body heat loss in older adults. Warm-water immersion will consist of a one-hour immersion in warm water with core temperature clamped at 38.5°C. Improvements in whole-body heat loss will be assessed during an incremental exercise protocol performed in dry heat (i.e., 40°C, \~15% relative humidity) prior to and following the 7-day passive heat acclimation protocol. The incremental exercise protocol will consist of three 30 minute exercise bouts performed at increasing fixed rates of metabolic heat production (i.e., 150, 200, and 250 W/m2), each separated by 15-minutes of recovery, with exception final recovery will be 1-hour in duration) performed in a direct calorimeter (a device that provides a precise measurement of the heat dissipated by the human body).


Eligibility Criteria:
Inclusion Criteria:

* Elderly (60-80 years), non-smoking adults.
* Not engaged in regular physical activity (\>2 sessions/week for ≥20 minutes per session).
* Willing to provide informed consent.
* Healthy, no diagnosed health conditions.
* Body Mass index (BMI) \<35 kg/m2.

Exclusion Criteria:

* Heat adapted due to repeated exposure to hot environments within the last 3 weeks (use sauna, recent travel to hot climates, other).
Evaluation of Two Hand Hygiene Products in ICUs

This study will evaluate the immediate antimicrobial efficacy and persistence of two hand hygiene products on ICU Health Care Worker's skin flora by measuring bacterial organisms on hands using the hand print method. It is hypothesized that the product containing Chlorhexidine gluconate will provide more persistence than the alcohol product, resulting in less bacterial growth on the hand print plates. In addition, environmental monitoring for cleanliness will be captured from high touch surfaces in ICU patient rooms and common areas using Rodac plates and adenosine triphosphate tests.

Crossover study with 50 Health care workers using each product with a minimum of 3 days in between. Products will be applied twice as per manufacturer's instructions for a Healthcare Personnel Handwash followed by immediate hand print. Persistent hand prints will be collected after exposure to environmental contaminants in the common areas. Hand prints will also be collected from one hand of 60 patients cared for by a participating Health Care Worker and gloved hand of Health Care Worker. All media contain neutralizers to inactivate active ingredients in each product and on surfaces. Each hand print plate's area of growth will be measured for Colony Forming Units using computerized software.

Eligibility Criteria:
Inclusion Criteria:

* HCW willing to participate in the study
* HCW willing to use non-Triclosan soap when soap is necessary throughout the study
* HCW who will don gloves prior to ICU patient room entry

Exclusion Criteria:

* Use of any CHG -containing products ( liquid hand soap, Sage wipes) on the ICU 72 hours prior to study initiation and throughout study
* HCW with patient bandage or other dressing on palm(s)
* Known sensitivity or allergy to CHG or alcohols in hand hygiene products
* Known sensitivity or allergy to the following components: Lecithin, Polysorbate 80,Trypticase Soy Agar, sodium bisulfate, sodium thioglycollate, sodium thiosulfate
* History of skin allergies
Novel Method to Diagnose Acute Myocardial Ischemia

The aim of this study is to improve the detection of heart attack in people who come to a hospital emergency room (ER) with cardiac symptoms. We are testing a novel technology that calculates the heart's electrical activity at points all around the upper body torso and develops a map showing areas indicating heart attack. Our hypothesis is that this new body mapping technique will be better than the standard electrocardiogram (ECG) in detecting heart attack.

The overall aims of the proposed research are (1) to improve the ECG diagnosis of patients who present to the ER with heart attack and (2) to improve the monitoring of recurrent heart attack in these patients while they are being treated in the hospital. The proposed research will test a promising new technique, termed estimated body surface potential mapping. This novel method involves estimating ECG information across the entire upper body from 10 electrodes placed in strategic positions.

In patients who come to the ER complaining of chest pain, shortness of breath or some other symptom of a heart attack, we will: (1) record continuous, 24 hour, standard ECGs (usual, current method used) and at the same time (2)record continuous 24 hour experimental recordings from which a body surface map will be calculated. Two experts who do not know whether the patient actually had a heart attack or not will analyze these 2 methods for signs of heart attack. We expect that more correct diagnoses will happen with the new experimental body mapping technique. The correct diagnosis will be based upon a blood test which is considered the best test to prove there is heart damage. The blood test does not become abnormal until hours after the attack, however, so the ECG diagnosis must be made and treatment initiated before results of the blood test are available.

If the expected diagnostic improvements are confirmed in this study, the long term benefit would be more accurate ER decision-making of patients with heart attack and more timely treatment. The benefits of more timely and definitive treatment would be an improvement in long-term survival, functional status, and quality of life in patients treated for heart attack.

We plan to enroll 1,320 patients who present to the ER at the University of California, San Franicsco to participate in the study. We will follow these patients for a year following their ER visit to determine whether they survived and which ECG method predicted death more accurately.

Eligibility Criteria:
Inclusion Criteria:

* All individuals who present to the UCSF emergency room between 7 am and 7 pm, Monday through Friday, who have symptoms of myocardial infarction.

Exclusion Criteria:

* Patients with left bundle branch block or ventricular pacemaker rhythm
Safety and Pharmacokinetics (PK) of hOKT3g1 (Ala-Ala) in Type 1 Diabetes Mellitus (T1DM)

To assess the tolerability and safety of hOKT3g1 (Ala-Ala) after a 12-day dosing regimen administered via intravenous infusion. To assess the pharmacokinetics of hOKT3g1 (Ala-Ala).


Eligibility Criteria:
To be eligible

* participants will have Type 1 diabetes, diagnosed within the previous 12 months and established by standard American Diabetes Association criteria.
* All participants will have autoantibodies: either anti-GAD65, anti-ICA512, or if treated with insulin for less than 7 days, anti-insulin.
* The age range will be between 8 and 30 years; and
* a minimum weight of 34 kg.
Lipoprotein Metabolism in Hypertensive African-Americans

To study relationships among lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females. The study was part of a Collaborative Project on Minority Health which investigated the mechanisms by which insulin contributes to cardiovascular disease.

BACKGROUND:

The study was part of the initiative "Collaborative Projects (R01s) on Minority Health". The concept for the initiative was developed by the NHLBI staff after the 1993 Report of the Committee on Appropriations, House of Representatives, encouraged the NHLBI to establish minority centers to facilitate the diagnosis and treatment of cardiovascular diseases. The initiative was approved at the September 1992 National Heart, Lung, and Blood Advisory Council and released in October 1992.

Julian Marsh was one of three investigators in a collaborative program with Bonita Falkner as Program Coordinator.

DESIGN NARRATIVE:

In a sub-set of subjects with either high or low plasma insulin levels after a glucose challenge (insulin sensitive or insulin resistant), the investigators determined the fractional and absolute synthesis and catabolic rates of apolipoproteins B and A-I, the dominant lipoproteins of Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). They used stable isotopes and multicompartmental kinetic analysis following an oral bolus dose of deuteroleucine. They hypothesized that in hypertensive African Americans with hyperinsulinemia, more of the smaller Very Low Density (VLDL) particles are secreted and converted to LDL.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility Criteria:
No eligibility criteria
Study of the Safety and Effectiveness of Esmirtazapine in Participants With Chronic Primary Insomnia (P05706)

The purpose of this study is to determine if esmirtazapine (Org 50081) is a safe and effective treatment for insomnia. It was anticipated that esmirtazapine would increase mean Total Sleep Time (TST) as recorded in sleep diaries relative to placebo.


Eligibility Criteria:
Inclusion Criteria:

* Has signed written informed consent after the scope and nature of the investigation was explained to them
* Has difficulty falling asleep, maintaining sleep or has early morning awakenings

Exclusion Criteria:

* Significant medical or psychiatric illness causing sleep disturbances
* Has a history of bipolar disorder or family (immediate family) of suicide
* Has sleep disorder such as sleep related breathing disorder, restless leg syndrome, narcolepsy
* Has significant other medical illness such as acute or chronic pain, heart, kidney or liver disease within the last year
* Currently diagnosed or meets the criteria for Major Depressive Disorder (MDD) or has been treated for MDD with the last 2 years
* Substance abuse, excessive use of alcohol (as determined by the physician) or drug addiction within the last year.
Mitigation Efforts in Arsenic Exposure With Folic Acid Supplementation

The purpose of this study is to evaluate the effects on folic acid supplementation in a population living in an environment with chronic arsenic exposure in Birmingham, Alabama.

Folic acid supplementation effects urinary arsenic excretion. In this project investigators propose to investigate if oral folic acid dietary supplementation can increase urinary arsenic metabolite excretion

Eligibility Criteria:
Inclusion Criteria:

* ≥18 years of age
* Resident of the superfund site
* Clinically stable with no significant changes in general health status in the past 4 weeks prior to screening as assessed by the investigator
* Provide written informed consent

Exclusion Criteria:

* Pregnancy
* Ongoing folic acid nutritional supplementation
* Methotrexate use
* Megaloblastic anemia
* Alcoholic liver disease
* Malabsorptive syndromes - celiac disease, inflammatory bowel disease
Nurtured in Nature

The investigators pilot test a Nature Coach Intervention in a population of postpartum women, to increase the amount of time people spend outside in local nature, with the goal of preventing postpartum depression.

Postpartum depression (PPD), characterized by feelings of sadness, irritability, and fatigue following the birth of a child, occurs in 10-15% of women. PPD peaks within the first 2-3 months following delivery, but can occur anytime in the first year, representing one of the most common complications of childbearing. The consequences go beyond impaired functioning for the woman, and include harmful effects on the cognitive and emotional development of the woman's infant. Despite this, many women are undiagnosed and do not get adequate treatment.

Living near and spending time in green space is associated with a host of mental health benefits, including reduced depression and improved well-being. Research has shown that women who live near more green space have improved birth outcomes such as higher birthweight infants.

Despite the growing body of evidence linking nature with improved mental health, spending time in green space is not a standard health promoting tool to address mental illness. Behavioral economics concepts have been used successfully in promoting other preventative health behaviors such as physical activity and healthy eating.

Eligibility Criteria:
Inclusion Criteria:

* 18 years old and older
* Delivery of a living child
* Ambulatory
* Live in West or Southwest Philadelphia
* Have a smart phone
* Able to understand and respond to an oral interview in English

Exclusion Criteria:

* Baby in Neonatal Intensive Care Unit
* Mother has not been in Intensive Care Unit pre/post-delivery
* Gestational age less than 37 weeks
* Department of Human Services involvement
Yoghurt Consumption, Body Weight Management and Glycemic Control of T2DM Patients

The study investigates the effects of consumption of yoghurt enriched with vitamins B compared to plain yoghurt, on body weight management and glycemic control of overweight/obese T2DM patients. It also investigates the effect of plain yoghurt consumption on gut hormones response of T2DM patients.

In a large number of epidemiological studies, low-fat dairy consumption has been associated with lower risk of T2DM. However, the number of randomized clinical trials which examine the impact of yoghurt consumption on glycemic control and body weight management of T2DM patients is small and include yoghurts fortified with vitamin D or probiotics. According to our knowledge, fortification of yoghurt with other classes of vitamins beyond vitamin D has not been examined. Vitamins of B-complex hold key-role in energy metabolism. In the state of diabetes mellitus, the requirements for this vitamin class may be higher because of their water solubility and increased excretion. Two groups of patients participated in the study. One group received yoghurt enriched with vitamins B and one group received isocaloric plain yoghurt. In addition, in order to investigate the effect of plain yoghurt on gut hormones, responses to a mixed meal tolerance test were evaluated in the beggining and the end of the dietary intervention.

Eligibility Criteria:
Inclusion Criteria:

* BMI 27-36
* HbA1C \< 8.5%
* Constant body weight and dietary habits for the last 3 months
* Stable dose of oral medication for at least 3 months
* Diagnosed with T2DM for more than 1 year

Exclusion Criteria:

* History of cardiovascular, gastrointestinal, renal and endocrinological diseases
* Treatment for weight reduction
* Lactose intolerance
* Allergies to milk and dairy products
* Alcohol consumption (\> 2 drinks per day)
* Intake of supplements
* Receiving insulin
Detecting Tumor Specific Amplitude-modulated Frequencies of Cancer Patients

Studies have shown that tumor specific amplitude-modulated frequencies of radiofrequency electromagnetic fields that is associated with biofeedback upon exposure to in cancer patients. However, such discovery in other cancer patients are rare. And whether tumor specific frequencies can be found in Asian cancer patients remains unclear. The purpose of this study is to detect the tumor specific frequencies of Asian cancer patients in vivo.

The measurements were safety guaranteed and were conducted in hospital. Before detecting, the patient will be already diagnosed with cancer. The doctor and the operator are responsible for the detecting. When cancer patients are exposure to the RF electromagnetic fields, the radial pulse amplitude, blood pressure, skin electrical resistance and breath will be monitored. Biofeedback parameters will be recorded at different modulation frequencies and analyzed in order to find the variation and tumor specific frequencies.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of cancer Disease

Exclusion Criteria:

* other patients
Hypertension of Our Patients: Knowledge, Control, Comorbidity

Numerous studies highlight the insufficiency of blood pressure control in treated hypertensive population \[1\].

As shown in the MONICA study, increased cardiovascular mortality is found in Alsace compared to other french regions. The incidence and prevalence of diabetes and obesity are likely explanatory factors leading to this excess mortality \[2\].

Furthermore, the incidence and prevalence of alsacian patients with end-stage renal failure (ESRD) is also higher than the national average. The high prevalence of diabetes, hypertension and obesity in this population is also probably responsible for the high prevalence of ESRD \[3\].

Opportunities to prevent the progression of kidney disease involve an optimal control of treatable evolutionary factors.

Beyond control of diabetes and obesity, optimization of blood pressure control are an important factor to consider, as national and international guidelines recommend lower blood pressure targets in this population \[4\]. Knowledge of the disease and treatment goals are a key component of hypertensive patient management. Studies have shown that the knowledge of hypertensive disease and therapeutic targets were correlated with treatment compliance and with the rate of blood pressure control \[5\]. Patient education and participation of non-medical actors (nurses, pharmacists, ...) are likely to improve the management and treatment compliance of these patients \[6\]. To our knowledge, no investigation has been performed in our region to determine the epidemiological characteristics, the knowledge level and blood pressure control in the population of hypertensive patients. The main objectives of this observational study are to evaluate, in a treated hypertensive population:

the knowledge level of the blood pressure treatment goals, the impact of patient knowledge on this blood pressure control, the potential impact of the patient's comorbidities on his blood pressure control.

Such a study should provide the basis for the feasibility of a large survey.


Eligibility Criteria:
Inclusion Criteria:

* Hypertensive patients moving spontaneously to their pharmacy to get their usual medications, including at least one drug in the class of anti-hypertensive

Exclusion Criteria:

* Refusal or inability of the patient to respond to the questionnaire.
* Antihypertensive therapy changed in the month preceding the survey.
* Antihypertensive therapy initiated within three months preceding the survey.
* Age \<18 years.
A Study on Pigmentation Disorders in Children

The descriptive cross-sectional study was undertaken at Kanti Children's Hospital during the period from January 2020 to June 2021. Ethical approval for the study was obtained from the Institutional Review Board of Kanti Children's Hospital (IRB-KCH). The refence number is 59/2020-021. The study focused on children with hyperpigmentation disorders presenting at the Dermatology Outpatient Department of Kanti Children's Hospital.


Eligibility Criteria:
Inclusion Criteria:

* children ranging from newborns to 15 years old with hyperpigmentation due to any cause

Exclusion Criteria:

* children admitted to wards
A Study to Compare the Drug Levels of Atazanavir and Cobicistat Between the Coadministration of Age-Appropriate Mini-Tablet Formulations and the Coadministration of the Individual Reference Products in Healthy Adults Under Fed Conditions

The purpose of this study is to evaluate the drug absorption of atazanavir and cobicistat between the coadministration of the mini-tablet formulations in applesauce or chocolate pudding followed by water and the coadministration of atazanavir oral powder in applesauce and cobicistat oral tablet followed by water in healthy adult participants.


Eligibility Criteria:
Inclusion Criteria:

• Body Mass Index (BMI) of 18.0 to 32.0 kg/m\^2, inclusive. BMI = weight (kg)/\[height(m)\]\^2

Exclusion Criteria:

* Significant acute or chronic medical illness
* History of a clinically significant drug rash, Stevens-Johnson Syndrome or Gilbert's Syndrome
* Inability to swallow oral medication
* Major surgery within 4 weeks of study treatment administration

Other protocol-defined inclusion/exclusion criteria apply
Bioavailability of Orally Ingested Vitamin C

The purpose of this study is to determine if crystalline vitamin C supplementation can acutely increase skeletal muscle vitamin C concentrations and if this can be potentiated by administering vitamin C using Phosphycell™ Technology - a phosphatidylcholine-lipid encapsulation technology.


Eligibility Criteria:
Inclusion Criteria:

* Body mass index (BMI) 18.5 - 30 kg/m2
* Age 18 - 40
* Non-smoker

Exclusion Criteria:

* Body mass index (BMI) \< 18.5 or \> 30 kg/m2
* Age \< 18 or \> 40
* Smoking
* Cardiovascular disease
* Hypertension (≥ 140/90 mmHg)
* Metabolic disease
* Medications known to affect vitamin C metabolism
* A known vitamin C deficiency
* Less than 2 hours per week of physical activity or following a structured exercise training program.
* Routine use of vitamin supplements