cyrilzakka/clinical-trials huggingface dataset:
Effect of Core Training on Physical Fitness and Smash Performance Among Female Badminton Players in Guangxi, China

The performance of Chinese women's badminton singles players is declining to a large extent, the training of badminton in China needs to catch up, and the talent ladder has caused a fault. Badminton Routine training, the effect is not apparent . An essay on the impact of core training on athletes' skill performance was written by Luo; it proves that core strength training plays a positive role in a variety of sports; there is no study of female badminton players. Coaches or sports researchers can use this knowledge to manage the training load of badminton players better, thereby helping badminton players achieve better results in badminton training and competition.

Hibbs constructed the Model of Core Training and Potential Performance according to the theoretical framework of core strength training. This study intervention design part of the researchers referred to Greg Glassman's "CrossFit training guide" and theoretical framework of core strength training. Motion design source form Motion design source "Diversified Training to Enhance Core Strength State General Administration of sport (Sport.gov.cn)"and Khatoon wrote the article. The duration and frequency of intervention came from the review. It is found in reviewing the effect of core strength training on badminton players' performance is 8 weeks and 3 times. Therefore, this study adopted intervention for 8 weeks, 3 times a week. The subjects of this study are 18-22 years old female college elite badminton players, all of whom are national second-level and above athletes. This study employs a Cluster Randomized Controlled Trial (CRCT) design. The athletes were randomly assigned to two training sites and divided into experimental and control groups. The two groups had the same professional skills training content. The only difference was the physical training part. The training program of the two groups lasts 8 weeks, 3 times per week, and 1 hour per training. The experimental group performed core training, while the control group maintained routine training. In addition, the specific content of the routine training of the control group was the standard training plan of the school. The dependent variables measured in this study are physical fitness (strength, speed, endurance, agility, and flexibility) and killing the ball under different states, including in sit Smash, jump smash, move left smash, move right smash, and back smash.

Eligibility Criteria:
Inclusion Criteria:

1. Aged 18-22 years.
2. Chinese university female badminton players.
3. No sports injuries, such as ankle injuries or waist injuries.
4. Elite athlete

Exclusion Criteria:

1. Athletes who were systematically training their core strength.
2. Athletes with sports injuries such as ankle or waist injuries.
3. Who could not follow the entire training schedule for three months.
4. Students who work out regularly or have hobbies for extra physical exercise.
5. Students with physical or mental illness.
Applying Pulse Wave Analysis to Predict Intradialytic Hypotension

Intradialytic hypotension (IDH) is a common complication during hemodialysis in patients with chronic kidney disease and may increase the mortality. This study aimed to investigate whether pulse wave analysis could be the predictor of IDH.

In this study, patients under regular hemodialysis were enrolled from Taoyuan Chang Gung memorial hospital. Subjects were evaluated by pulse wave instrument, heart rate variability analyzer and Constitution in Chinese Medicine Questionnaire before hemodialysis. According to the definitions of IDH, subjects in study group and control group were confirmed by the dialysis records. Furthermore, repeated examinations were done for 3 hemodialysis to investigate the possible predictive factors for IDH.

Intradialytic hypotension (IDH) is a common complication during hemodialysis in patients with chronic kidney disease and may increase the mortality. This study aimed to investigate whether pulse wave analysis could be the predictor of IDH.

In this study, patients under regular hemodialysis were enrolled from Taoyuan Chang Gung memorial hospital. Subjects were evaluated by pulse wave instrument, heart rate variability analyzer and Constitution in Chinese Medicine Questionnaire before hemodialysis. According to the definitions of IDH, subjects in study group and control group were confirmed by the dialysis records. Furthermore, repeated examinations were done for 3 hemodialysis to investigate the possible predictive factors for IDH.

Eligibility Criteria:
Inclusion Criteria:

* patients under regular hemodialysis (3 times per week) in last 3 months

Exclusion Criteria:

* arrhythmia
* artery-vein anastomoses on both arms
* other conditions which might interfere the evaluation of pulse wave analysis and heart rate variability analysis
Healthcare Resource Utilisation, Common Mental Health Problems, and Infections in People With Inflammatory Bowel Disease

Ulcerative colitis and Crohn's disease are the commonest types of inflammatory bowel disease (IBD). Both conditions range in severity from no symptoms to being potentially fatal. Both conditions are treated with medications which suppress the immune system. It is not known whether this increases the risk for infections and cancers in these conditions. It is also recognised by healthcare professionals that these conditions cause a considerable amount of psychological distress. However, this has never been measured in a large population sample.

This study will investigate any associations with treatment and new onset infections and cancer. They will also examine the relationship between IBD and common mental health problems (specifically, depression and anxiety) and the impact that these have on the healthcare use (including number of general practitioner \[GP\] appointments, hospital attendances, and medication prescriptions. Combined, these studies should provide a better understanding of the impact of IBD on affected people and provide evidence to support the correct allocation of healthcare resources.

Objective We aim to provide an accurate and contemporary measurement of the current healthcare resource utilisation in people with inflammatory bowel disease (IBD); namely ulcerative colitis (UC) and Crohn's disease (CD). We also aim to provide estimates of infection incidence in this population and the prevalence of common mental health conditions.

Method We will identify UC and CD using algorithms validated for accurately identifying these conditions from primary care records in the United Kingdom (UK). We will identify a prevalent cohort of adults with IBD with the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) network over the last decade. We will identify a matched cohort of people without IBD; matched on age, gender and primary care practice. Across these cohorts we will compare healthcare resource utilisation (primary care attendances, number of primary care prescriptions for antidepressant and anxiolytic medications, number of primary care prescriptions for medications used in IBD, recorded secondary care attendances, and issue of statements of fitness for work), incident infections (any common infection, any viral infection, or any gastrointestinal infection), and common mental health conditions (depression and anxiety).

Eligibility Criteria:
Inclusion Criteria:

* Patients aged ≥18 years over the study period
* Registered with a contributing primary care practice for any duration during the study period

Exclusion Criteria:

* IBD not classifiable or of a type other than UC or Crohn's disease
Pneumonia Due to Stenotrophomonas Maltophilia in ICUs

Pneumonia is a major cause of ICU admission, or may complicate ICU course. Among the causative pathogens, Stenotrophomonas Maltophilia is a rare pathogen, but affects usually patients with chronic pulmonary co-morbidities, or with long duration of mechanical ventilation and multiples treatment with broad spectrum antimicrobial therapy. However, there are only a paucity of data regarding epidemiology, impact and outcome of Pneumonia due to Stenotrophomonas Maltophilia in critically ill patients.

Primary objective was to study factors associated with mortality in case of Pneumonia due to Stenotrophomonas Maltophilia. Secondary objectives were to describe factors associated with morbidity of Pneumonia due to Stenotrophomonas Maltophilia (duration of mechanical ventilation, ICU length of stay), and to report the characteristics of critically ill patients presenting Pneumonia due to Stenotrophomonas Maltophilia.


Eligibility Criteria:
Inclusion Criteria:

Patients older than 18 years

Documented Stenotrophomonas maltophilia pneumonia:

* Clinical suspicion (≥ two criteria including: fever\> 38.5°C, leukocytosis \> 10\^9/L or leukopenia \< 4.10\^8/L, purulent tracheobronchial secretions and a new or persistent infiltrate on chest radiography).
* Documented Stenotrophomonas maltophilia positive quantitative culture of a respiratory sample: bronchoalveolar lavage fluid (significant threshold, \>10\^4cfu/ml) or plugged telescopic catheter (significant threshold, \>10\^3cfu/ml) or quantitative endotracheal aspirate (significant threshold, \>10\^6cfu/ml).

Exclusion Criteria:

* None
Pattern of Cardiac Arrhythmia in Patients With MASLD

Study the relationship between patients with MASLD and cardiac arrhythmia that could be occur in thos patients

Study the cardiac arrhythmia that could be occur in patients suffering form metabolic dysfunction -assocatied steatotic liver disease and risk factors of them

Eligibility Criteria:
Inclusion Criteria:

* patients aged 18years or older Patients with metabolic dysfunction -assocatied steatotic liver disease

Exclusion Criteria:

* RHD Structural heart diseases Liver diseases other than MASLD
Cortical Plasticity in a Complex Intervention for Endometriosis

The aim of the study is to test, if patients suffering from Endometriosis show changes in their brain function, when being treated with SART (Systemic Autoregulation Therapy), a complex intervention consisting of interventions from Traditional Chinese Medicine (TCM) and Western Hypnotherapy. Functional and structural brain changes are assessed using Magnetic Resonance Imaging data which are analyzed by means of voxel-based morphometry (VBM), connectivity and perfusion analysis. A third outcome measure are changes of patients' heart rate variability, indicating the activity of their autonomic nervous system.

With a number of questionnaires, changes in dysmenorrhea, chronic pelvic pain, menstruation regularity, dyspareunia, defecation pain, and quality of life are assessed during the SART treatment.

During the treatment, we expect to see changes in cortical thickness, functional connectivity and perfusion of pain-related areas of the cortex, that correlate with the changes in heart rate variability.


Eligibility Criteria:
Inclusion Criteria:

* age \> 18 years old
* clinically or histologically ensured diagnosis of Endometriosis
* preoperative and postoperative recurring ailments related to Endometriosis
* no hormone therapy (GnRH analogues, contraceptives)
* sufficient understanding of the German or English language
* persisting pain during menstruation (also in between)
* voluntary participation after information on the possible benefits and risks of the examination and intervention
* written informed consent

Exclusion Criteria:

* alcohol addiction, drug addiction
* pregnancy
* diseases and other criteria, preventing an MRI examination:
* pacemaker
* neurostimulator or drug pump
* metal parts in the body (implants, splinters, etc.)
* claustrophobia
Phase 1 Study in Healthy Subjects to Evaluate the Effect of Rifampin on the Pharmacokinetics of IPI-145

To evaluate the effect of rifampin, a cytochrome P450 3A (CYP3A) inducer, on the pharmacokinetics (PK) of IPI-145; to assess the safety and tolerability of IPI-145 when administered with rifampin in healthy subjects

* In Treatment Period 1, subjects will receive a single 25 mg oral dose of IPI-145
* In Treatment Period 2, on Days 3-9, the same subjects will receive once daily (QD) oral doses of 600 mg rifampin; on Day 9, subjects will receive a single oral dose of 25 mg IPI-145 concomitantly administered with 600 mg of rifampin

Eligibility Criteria:
Inclusion Criteria:

* Healthy men or women of non-childbearing potential between 18-50 years of age
* Body Mass Index (BMI): 18.0 - 32.0 kg/m2
* In good health, determined by no clinically significant findings from clinical evaluations
* Provided written informed consent prior to any study specific procedures

Exclusion Criteria:

* Women of childbearing potential
* Evidence of clinically significant medical conditions
* History of gastrointestinal disease or surgery that may affect drug absorption
* Positive or indeterminate Tuberculosis -spot test at screening
* Any active infection at the time of screening or admission
* Consumption of any nutrients known to modulate cytochrome P450 enzyme activity within 14 days prior to administration of study drug, during the study, and until after discharge
Measurement of the Cerebral Saturation for Assessment of Safety of Epidural Anaesthesia During Abdominal Surgery

Subsequent and non-randomised patients, adult patients qualified for major abdominal surgeries were enrolled


Eligibility Criteria:
Inclusion Criteria:

* scheduled for major abdominal surgery for at least 2 h
* under general anesthesia
* American Society of Anesthesiologists（ASA）physical status : II \~ III
* Age \> 18

Exclusion Criteria:

* refuse of patients
* patient with results of test: "The Mini Mental State Examination"" less then 24 before operation
* neurosurgery history of patients
Efficacy and Safety Study of Titrated Oral Misoprostol Solution for Labor Augmentation

The purpose of this study is to compare the efficacy and safety of titrated oral misoprostol solution with intravenous oxytocin for labor augmentation in women without adequate uterine contractions.

Numerous labor course necessitate augmentation when uterine contractions are inadequate. When the cervix is favorable, labor augmentation attempts are more likely to be successful. Augmentation is these women is traditionally undertaken with intravenous oxytocin and amniotomy, either alone or in combination.

In our previous trial, it has been proven that the method of titrated oral misoprostol is associated with a lower incidence of uterine hyperstimulation and a lower cesarean delivery rate than vaginal misoprostol for labor induction in patients with unfavorable cervix. Because administering Misoprostol solution is easy and cost saving, it is worth to develop this novel method in labor augmentation.

Eligibility Criteria:
Inclusion Criteria:

* Pregnancy between 36 and 42 weeks of gestation
* Live singleton
* Cephalic presentation
* A reassuring fetal heart rate pattern
* Bishop score greater than 6
* Inadequate uterine contraction (less than or equal to 2 per 10 minutes)

Exclusion Criteria:

* Nonreassuring fetal heart rate pattern
* Parity more than five
* Uterine scar
* Suspected placental abruption with abnormal fetal heart rate
* Vaginal bleeding other than "bloody show"
* Significant maternal cardiac, renal, or hepatic disease
* hypersensitivity to oxytocin, misoprostol or prostaglandin analogues
Casodex 150-mg Compassionate Use Trial for Subjects With Prostate Cancer

This study provides compassionate use of bicalutamide (Casodex) at a 150-mg dose for subjects with prostate cancer prior to it becoming commercially available. The patient will receive bicalutamide 150-mg as long as the physician feels that the subject is benefiting from this therapy and safety information is provided regularly to AstraZeneca. Treatment will be discontinued after bicalutamide 150-mg becomes commercially available.


Eligibility Criteria:
Inclusion Criteria:

* Patients with adenocarcinoma of the prostate
* Subjects with locally advanced, and/or metastatic prostate cancer for whom surgical castration or other medical interventions are not considered appropriate or acceptable

Exclusion Criteria:

* Any known history of abnormal liver function tests
* Any severe concomitant condition that would make it undesirable, in the clinician's opinion, for the subject to participate in the trial.
* Known hypersensitivity to bicalutamide or any of the components found in bicalutamide
Treatment Study of Bipolar Depression

The purpose of this study is to determine whether a single intravenous administration of an N-methyl-D-aspartate antagonist is safe and effective for the acute treatment of bipolar depression.

Bipolar disorder (BPD) is a common, recurrent, and disabling medical condition. Although mania is the defining feature of BPD, depression represents the majority of illness burden in patients with this devastating condition. Despite the high degree of morbidity and mortality associated with bipolar depression, currently available treatments are few and often inadequate. Recently, a single intravenous (IV) dose of the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in severe unipolar depression. Therefore, the objective of the current study is to investigate the safety and efficacy of a single IV dose of ketamine in treatment-resistant bipolar depression (TRBD).

Eligibility Criteria:
Inclusion Criteria:

1. Male or female patients, 21-70 years;
2. Primary diagnosis of bipolar I or II disorder as assessed by the SCID-P and confirmed by a study psychiatrist;
3. Current depressive episode ≥ 8 weeks duration;
4. History of a failure to respond to at least three (3) adequate pharmacotherapy trials in the current depressive episode (see above for definition for adequate trials);
5. Subjects must be on a stable dose of divalproex ER with serum levels greater than 55 mcg/ml prior to enrollment;
6. Subjects must be free of psychotropic medication for at least 2 weeks (4 weeks for fluoxetine) prior to enrollment (with the exception of divalproex ER as above);
7. Subjects must have scored ≥ 32 on the IDS-C30 at both Screening and Infusion Day #1 and #2;

Exclusion Criteria:

1. Women who plan to become pregnant, are pregnant or are breast-feeding;
2. Any unstable medical illness including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease;
3. Clinically significant abnormal findings of laboratory parameters, physical examination, or ECG;
4. Lifetime history of schizophrenia, schizoaffective disorder, OCD, mental retardation, pervasive developmental disorders, or Tourette's syndrome;
5. Current presence of psychotic, mixed or manic symptoms;
6. Lifetime history of antidepressant-induced switch to a manic episode;
7. History of rapid cycling bipolar subtype;
8. Drug or alcohol abuse within the preceding 3 months or dependence within the preceding 5 years;
9. Lifetime exposure to ketamine or phencyclidine;
10. Patients judged by study investigator to be at high risk for suicide.
USPIO Enhanced MR Imaging in CNS Tumours (UMIC)

The immune response or inflammation is known to be a key driver of progression and growth in many solid tumours. Inflammatory cells called macrophages are present in high numbers in many brain tumours and these tumour associated macrophages or TAM are thought to have prognosis and treatment implications in these tumours. A key question, however, is how this inflammation or TAM abundance can be detected, measured and monitored in the clinic. A clinically applicable imaging test that can directly and accurately measure tumour macrophage content would be of considerable value and one technique that may provide this is USPIO enhanced magnetic resonance imaging (MRI). Following intravenous injection, USPIO or ultrasmall superparamagnetic iron oxide nanoparticles, circulate in the bloodstream before being taken up by inflammatory cells/macrophages in tumour tissue, wherein they can be detected by MRI. This pilot study is to evaluate if a commercially available USPIO preparation called ferumoxytol (Feraheme ©) can accurately quantify macrophage abundance in brain tumours, with an exploratory focus on vestibular schwannoma (VS) and suspected transforming low-grade glioma (LGG). Patients with both non-growing (static) and growing VS, and patients with suspected transforming LGG will undergo dedicated MRI sequences before, immediately after (\< 2 hours) and at both 24 and 48hrs after ferumoxytol administration. In patients undergoing surgery, acquired imaging will be compared with resected tumour tissue so that markers of inflammation can be compared with USPIO uptake. Through advanced laboratory methods this study will seek to establish within resected VS and LGG specimens: the cellular destination/s of USPIO uptake; the nature of the inflammatory and/or tumour cells containing the USPIO; and the relationship between USPIO uptake and tumour blood vessel permeability or leakiness.


Eligibility Criteria:
Inclusion Criteria:

* Be at least 16 years old
* Have a CNS tumour suspected to be one of the defined histological types (vestibular scwhannoma or low grade glioma)
* Be able to lie still for up to 1 hour comfortably
* Opinion of the treating clinician is that the patient will be able to successfully complete the research imaging protocol.

Exclusion Criteria:

* Life expectancy less than 1 year
* Previous CNS radiotherapy/ stereotactic radiosurgery (SRS)
* Females who are pregnant/ breastfeeding
* Patients with an eGFR \< 30ml/min
* Patients with known and documented history of iron overload/haemosiderosis/ haemochromatosis
* Patients with immune or inflammatory conditions e.g. systemic lupus erythematous, rheumatoid arthritis
* Patients with absolute (e.g. pacemaker) and relative (anxiety or claustrophobia) contraindications to MR scanning
* Patients with a history of allergic reaction to iron or dextran
* Patients with a history of allergic reaction to gadolinium contrast agents, asthma or renal problems
* Patients who are unable to adequately understand verbal explanations or written information given in English.