cyrilzakka/clinical-trials huggingface dataset:
Continuous Assessment of Hemodynamic Compensation in Pediatric Trauma Patients

This is an observation study using the Flashback CRI T1 tablet to collect data on compensatory reserve index in pediatric trauma patients. Highest trauma activations at the institution will be enrolled in the study and data will be collected for 12-24 hours based on the patient's hemodynamic status. The device collects data via a pulse oximeter probe. No treatment decisions will be made based on the values of the on the CRI tablet. Data will be retrospectively reviewed to determine if any trends exist that correlate with blood loss, need for operation or blood transfusion.


Eligibility Criteria:
Inclusion Criteria:

• Children 31 days through 26 years (inclusive) of age who undergo Trauma Red (highest level) activation or Trauma Level 1 (mid-level) activation at Children's Hospital Colorado or Children's National Medical Center.

Exclusion Criteria:

* Pregnant patients
* Incarcerated patients
* Patients who object to study participation at any time
* Limited access to or compromised monitoring sites for non-invasive finger sensors
* Brain death (GCS 3 with fixed, dilated pupils)
A Study of Risk Factors for Venous Ulceration in Patients With Varicose Veins of Lower Extremities.

Varicose veins of lower extremities can lead to adverse consequences such as ulceration and hemorrhage, which seriously endangering the physical and mental health and quality of life for patients.

The aim of this study is to explore the potential risk factors of venous ulceration in patients with varicose veins of lower extremities based on a case-control study, and to provide a reference for personalized treatment.

Varicose veins of lower extremities are common chronic diseases. The main clinical manifestations are lower extremity weakness, heaviness, burning sensation, itching, swelling or pain, and severe cases are often accompanied by complications such as changes in skin color, ulceration and hemorrhage. Venous ulceration is one of the main complications of lower extremity varicose veins, accounting for more than 75% of all lower extremity ulcers. Venous ulceration are difficult to heal and prone to recurrence. Studies have shown that the recurrence rate of venous ulceration is as high as 67%. The refractory and high recurrence rate of venous ulceration not only have a serious impact on the quality of patients' life, but also bring a heavy economic burden on society.

Venous ulceration in varicose veins of lower extremities patients may linked to different causes, including past medical history, comorbidity, inflammatory response, etc. The purpose of this study is to collect demographic characteristics, lifestyle characteristics, laboratory indicators, past history, comorbidity and other information by using the data set of patients with varicose veins of lower extremities based on the Shandong Provincial Qianfoshan Hospital Healthcare Big Data Platform. To explore the potential risk factors of venous ulceration in patients with varicose veins of lower extremities through case-control study.

Eligibility Criteria:
Inclusion Criteria:

1. Clinical diagnosis of varicose veins of the lower extremities
2. Hospitalized patients
3. 18 years old or older

Exclusion Criteria:

1. Patients with any other conditions that could also lead to venous ulceration including peripheral artery disease, diabetes, and pressure ulcers
2. Patients with heart, liver and kidney failure
3. Patients with malignant tumor
Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)?

A leak from a colorectal anastomosis is a post-operative complication surgeons fear the most, following colonic resection. Over the years, there have been multiple suggestions for intraoperative tests for the integrity of the colorectal anastomosis.

Two of the most common tests that are performed routinely are:

1. Air tight leak test - filling the pelvis with saline and insufflating air trans anal - looking for air bubbles in the saline filled pelvis.
2. Injecting diluted dye (methylene blue) trans anal, and looking for blue dye stains on gauze pads covering the outer side of anastomosis.

The aim of the study is to compare the two methods, and to assess if there is a superior method. A secondary aim is to establish standards to perform the test, mainly to assess the appropriate pressure to apply on the anastomosis.

In this prospective study patients scheduled to undergo colonic resection of their distal part of the colon/ rectum with colorectal anastomosis, will have both testing methods performed sequentially and will be followed post-operative to assess the yield and sensitivity of the testing methods.


Eligibility Criteria:
Inclusion Criteria:

* Patients over the age of 18 undergoing elective colonic resection of their distal part of the colon/ rectum with colorectal anastomosis in a laparoscopic or open approach for a benign or malignant colonic disease.

Exclusion Criteria:

* Emergent colonic resections,
* Colonic resections with no colorectal anastamosis
S100 Biomarker in the Acute Management of Mild Head Injuries

A prospective validation study of the "Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults". Enrolling a consecutive sample of 1000 adult head injury patients from the emergency department of the Tampere University Hospital (Tampere, Finland). A venous blood sample with S100 analytics (+storage blood) is drawn from every patient. The patients are head CT-scanned according to the SNC guidelines. Outcome assessment (GOSE, MRS, Rivermead PCS Questionnaire) is completed as follows: 1 week, 6 months, 1 year, and 2 years.

A prospective clinical head injury study conducted at the Emergency Department of the Tampere University Hospital, which is situated in Tampere, Finland. The hospital takes care of an catchment area of 524 447 inhabitants both from urban and rural areas. About 100 000 patients are treated in the Emergency department annually.

The study aims to improve the emergency evaluation of patients with an acute head injury, especially a mild head injury. About 80% of head CT scan performed on head injury patients in the Emergency Department of the Tampere University Hospital are negative (= no acute traumatic lesion). There is an urgent need to update the head CT imaging criteria/indications in the context of acute head injury in order to reduce the number of unnecessary scanning. More selective head CT indications result in considerable health care savings and decreased exposure to ionizing radiation, among other benefits.

In this study, the investigators implement the "Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults" criteria as part of the emergency care of adults head injury patients. By enrolling a large consecutive sample of patients the investigators are validating this new guideline. Emergency department assessment data is combined with long-term outcome parameters and blood-based biomarkers of neurotrauma.

The main aims of the study are:

1. the validation of the Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults
2. the examination of novel blood-based biomarkers of acute brain injury that correlate with the radiological severity of the injury and the long-term outcome

Eligibility Criteria:
Inclusion Criteria:

* Head injury

Exclusion Criteria:

* Age under 18 years
Surgical Site Infiltration Using Ketamine Versus Bupivacaine for Analgesia in Post-operative Appendectomy Operation

surgical site infiltration using ketamine versus Bupivacaine for analgesia in post-operative Appendectomy operation by Ketamine versus Bupivacaine


Eligibility Criteria:
Inclusion Criteria:

* 60 adult patients with ASA physical physical status class 1 and class 2 undergoing uncomplicated appendectomy under general anesthesia

Exclusion Criteria:

* Patient refusal
* drug abuse
* Patient with neurological, psychiatirc or neuromuscular disease
* chronic pain on medicine
* known allergy to the study medicine
* Infection at the site of infiltration
Effect of Rigid Tapping on Chronic Functional Ankle Instability in Basketball Players

This study aims rigid tapping on chronic functional ankle instability in professional basketball players.

Lateral ankle sprains (LASs) are common injuries in sports and physical activities, with up to 40% of individuals experiencing a first-time LAS developing chronic ankle instability (CAI). LASs predominantly affect the anterior talofibular ligament, and residual symptoms can persist in a significant percentage of patients. However, many individuals with ankle sprains do not seek professional treatment, leading to potential underestimation of the injury severity. CAI is characterized by recurrent episodes of ankle giving way, ongoing symptoms, reduced ankle range of motion, diminished self-reported function, and persistent ankle sprains beyond one year. It is attributed to both mechanical and functional instability, with factors such as proprioceptive deficits and mechanical insufficiencies contributing to the condition. Taping, particularly rigid taping, is commonly used by athletes to enhance joint stability and improve dynamic balance and functional performance. Rigid taping limits joint movement, improves joint position, and provides external support without compromising functional performance. Taping is especially prevalent in multidirectional sports like basketball, where ankle sprains are frequent. The use of tapes aims to restrict ankle movement, increase joint stability, and enhance proprioception without hindering athletic performance.

Eligibility Criteria:
Inclusion Criteria:

* Basketball players with age range from 18-40 years old.
* Body mass index (BMI) range from 18-25 H/m2.
* Participants had episodes of subjective sensation of instability in the last six months.
* Participants have at least moderate ankle instability, defined as a score of \<25 on the Cumberland Ankle Instability Tool (CAIT).

Exclusion Criteria:

* Participants had a history of surgery or fractures in the ankle joints.
* Participants had a neurological or vestibular disorder.
* Participants were unable to understand the nature of the protocol and test instructions.
Cooperative Extension and Cancer Survivorship

The goal of this clinical trial is to learn if a cancer survivor program, delivered via Cooperative Extension, is feasible and if it can improve health outcomes in cancer survivors who are post-active treatment.

Aim 1: Evaluate the feasibility and acceptability of SUCCESS. Hypothesis 1: SUCCESS will be feasible and acceptable as evidenced by delivery of the intervention among Educators (implementation), including in agreement with the curriculum in Phase 1 (fidelity) with \>85% attendance (demand) among participants with \>80% rating the intervention as acceptable or highly acceptable on 5-point Likert-type scale (acceptability).

Aim 2: Determine the preliminary efficacy of SUCCESS for improving HRQOL (primary outcome) and other psychosocial and health-related endpoints (e.g., financial toxicity) (secondary outcomes). Hypothesis 2: Compared to matched controls, adults LWBC who complete SUCCESS will have significant improvements in HRQOL per the PROMIS Global Health v1.2 at follow-up (i.e., after 6 weeks).

Aim 3: Examine changes in conserved transcriptional response to adversity (CTRA) gene expression in a subset of interventions participants at follow-up. Hypothesis 3: Adults LWBC who complete SUCCESS will experience significant CTRA down-regulation.

This is a single arm trial and there is no comparison group.

Participants will be asked to do survey- and Zoom-based data collection before and after completing the 6-week program.


Eligibility Criteria:
Inclusion Criteria:

* Previous adult-diagnosed cancer
* Post active cancer treatment
* No current active treatment, hormonal therapy permitted
* Ability to get to group sessions
* In Oklahoma

Exclusion Criteria:

* Current palliative or hospice care
* Surgical or medical history that precludes participation
* Positive screen on the Physical Activity Readiness Questionnaire+ (PAR-Q+) without a doctor's note approving study participation
Efficacy and Safety Study of CD 2027 Spray in Subjects With Plaque-type Psoriasis

This was a multicenter, randomized, vehicle-controlled, double-blind parallel group study to evaluate the efficacy and safety of CD 2027 Oily Spray applied twice daily for 8 weeks in participants with plaque-type psoriasis.


Eligibility Criteria:
Inclusion Criteria:

* Participant has a diagnosis of plaque-type psoriasis up to 20% of body surface area (BSA) involved excluding the scalp, with a Global Severity Score of at least 3 (moderate) at Screening
* Participant presents with a representative target lesion that is at least 16 cm² in area, is located on the non-bony areas of the skin, has a Scaling Score up to 2 (moderate), has a DSS of at least 4

Exclusion Criteria:

* Other type of psoriasis (other than plaque)
* Significant abnormal lab findings
* Hypercalcemia
Oncology Care Pathway's Modifications Impact During COVID-19 Pandemic : the ONCOCARE-COV Study

In december 2019, SARS-CoV2 and its clinical manifestations, COVID-19, appeared in China and caused a pandemic. It led decision makers to prioritize emergency and intensive care dedicated to infection management. Other conditions, such as cancer screening, diagnosis, and treatment, may have been delayed during the containment period. Consequences of this "distraction effect" are being.

Quantitative monthly data were analyzed from January 1, 2019 to May 31, 2020 in two French tertiary care center (University Hospital and Godinot Cancer Institute in Reims) and in a third center in the French epicenter (Colmar hospital). Oncologic activity indicators were extracted using oncologic electronic file, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) and nation-wide procedure codes (CCAM). The monthly number of different steps of oncology care pathway (screening, diagnosis and treatment) were collected: faecal immunochemical testing (FIT), mammography, histopathological and biomolecular/genetics analysis, nuclear medicine imaging, oncogeriatric evaluations, multidisciplinary tumor board meetings and files reviewed by meeting including first presentations, given personalized care program, medical announcement and reformulation nursing consultations, inserted central venous catheters, chemotherapy prepared and administered in chemotherapy day care, carcinologic surgeries and radiotherapy courses.

Eligibility Criteria:
Inclusion Criteria:

* Every adult patient entering an oncology care pathway between 01/01/2019 and 31/12/2020

Exclusion Criteria:

* \<18 yo
Chronic Heart Failure - Cheyne Stokes Respiration - CS2 (3C-study)

An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.

Chronic heart failure (HF) is one of the most important public health problems in cardiovascular medicine.

Several patients with chronic heart failure also has Cheyne Stokes respiration pattern. Earlier studies have shown that this respiration pattern improves with Adaptive servo ventilator. We wish to investigate wether this leads to improved cardiac function.

Eligibility Criteria:
Inclusion Criteria:

* Ejection fraction \<40%
* NYHA class III-IV
* Optimized therapy with drugs
* Cheyne stokes respiration pattern \> 25% while sleeping
* Age \< 85 years
* clinical stability the last month before inclusion.

Exclusion Criteria:

* CABG less then 6 months ago
* PCI treatment less then 3 months ago
* Unstable angina pectoris
* Acute coronary syndrome less then 3 months ago
* Stroke less then 6 weeks ago
* Thoracal myopathy
* Advanced COPD
Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series

The objective of the present study was to assess the effectiveness of deep dry needling in the masseter and temporalis MTrPs on pain, pressure pain threshold (PPT), range of motion and disability in patients with sleep bruxism and myofascial temporomandibular disorders.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of myofascial temporomandibular disorders
* Diagnosis of myofascial trigger point
* Diagnosis of sleep bruxism

Exclusion Criteria:

* insurmountable fear of needles
* any systematic joint or muscle disease
* bleeding disorders or
* prior physical therapy treatment
Study of URC102 to Assess the Safety and Efficacy in Gout Patients

The purpose of this study is to assess safety, Pharmacokinetics/Pharmacodynamics and Urate Lowering Effect of URC102 in gout patients.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with gout

Exclusion Criteria:

* Participated in other clinical study within 12 weeks prior to enrollment, and received an investigational product (including placebo)
Biomarkers in EV Associated with Marrow Adiposity in Anorexia

The aim of this observational study is to identify biomarkers in extracellular vesicles associated with medullary adiposity occurring in patients with anorexia nervosa. The main question it aims to answer is:

Can this medullary adiposity be associated with the bone deterioration observed in this population?

Participants will be assessed for body composition and a blood sample will be taken by non-invasive techniques.


Eligibility Criteria:
Inclusion Criteria:

For AN group:

* Diagnosis of active AN according to DSM-5 criteria
* BMI of less than 17kg/m2
* Present amenorrhoea in the 3 months prior to the start of the study.

For AN-R group:

* Achieved weight gain of more than 85%.
* Normal menstruation in the last 3 months.

For Control group:

* Population of the same age and gender as the AN and AN-R groups.
* If pubertal population, presenting a chronological age of ± 2 years.
* Normal menstruation
* Normal BMI (\>18.5 kg/m2)
* No presence of previous dietary transtrons.

Exclusion Criteria:

* Not receiving oestrogens, contraceptives or glucocorticoids in the 3 months prior to the start of the study.
* Not to suffer from chronic diseases, such as diabetes, pathologies affecting the bone system or thyroid function.
* Do not take calcium or vitamin supplements.
Hip and Knee Scores

Patient-reported outcome measures (PROMs) are currently used for evaluating orthopaedic procedures. Nevertheless, there is no consensus in the different studies, making them difficult to compare . The score mapping (or cross walk) is a statistical model for estimating a score associated with an unmeasured score.

Moreover , Minimal clinically important differences (MCID) is the smallest change in a treatment outcome that a patient would identify as important. The MCID is also not clearly identified for the French population for the hip and knee orthopaedic scores.


Eligibility Criteria:
Inclusion Criteria:

* Hip osteoarthritis (certified by standard radiographs)
* Knee osteoarthritis ( certified by standard radiographs)

Exclusion Criteria:

* BMI ≥ 40
* Systemic inflammatory disease
* Pregnant
* Surgery revision
Influence of Routinely Adding Ultrasound Screening in Medical Department

Ultrasound (US) is widely used as a diagnostic tool in a hospital setting. In a medical department, diagnosis like heart failure or most kinds of heart diseases, hypervolemia, hypovolemia, pleural effusion, pericardial effusion, ascites, diseases in the gall bladder/bile tract, urine tract and venous thrombosis are common. US is the key diagnostic tool in these diagnosis, and on early diagnosis is crucial with respect to the patients well-being and inpatients workflow.

1. The aim is to study the clinical use of pocket-size US as a screening diagnostic tool in an medical department with respect to inpatients workflow and diagnostics.

Method: Patients admitted (in certain preset periods) to Department of medicine will be randomized to routinely adding an ultrasound examination with pocket-size device by residents on call. Time to definitive diagnosis, time to definitive treatment and time to discard will be recorded. US findings will be validated against standard echocardiography, or standard US/CT/MRI performed at the Radiological department.


Eligibility Criteria:
Inclusion Criteria:

* Patients admitted to Dep. of Medicine at Levanger Hospital

Exclusion Criteria:

* Not able to give informed consent
Promotion of Healthy Lifestyle Habits in a Primary Care Setting

Intervention aiming to promote healthy dietary and physical activity behaviors in adults with low socio-economic position in a primary health care setting


Eligibility Criteria:
Inclusion Criteria:

* age, high metabolic risk- poor lifestyle habits (diet and physical activity)

Exclusion Criteria:

* overt disease
A Study of RO5267683 in Healthy Subjects

This investigator-blind, subject-blind, randomized, placebo-controlled study will evaluate the safety, pharmacokinetics and pharmacodynamics of multiple ascending doses of RO5267683 in healthy volunteers. Subjects will be randomized to receive either RO5267683 or placebo orally daily for 28 days. Follow-up will be 10 weeks after the last dose.


Eligibility Criteria:
Inclusion Criteria:

* Healthy male and female subjects, 18 to 45 years of age,
* Body mass index (BMI) 18 to 30 kg/m2 inclusive, and a minimum weight of 50 kg at screening
* Female subjects must be surgically sterile or post-menopausal
* Male subjects must use a barrier method of contraception for the duration of the study and for 90 days after the last dose

Exclusion Criteria:

* History or evidence of any clinically significant disease or disorder
* Administration of an investigational drug or device within 3 months prior to dosing on Day 1
* Positive for hepatitis B, hepatitis C or HIV at screening
* Subjects on hormone replacement therapy who have not been receiving a stable dose for at least 2 months prior to start of dosing