cyrilzakka/clinical-trials huggingface dataset:
Diagnosis of Colonic Adenomas by Bright Narrow Band Imaging (B-NBI)

Early detection of colo-rectal adenoma using colonoscopy can prevent occurrence of colon cancers. While colonoscopy is a standard technique, it can miss early cancers. To improve the detection rate, Narrow Band Imaging (NBI) was introduced in 2006. It has been shown to compare favorably with chromo-endoscopy in the sensitivity and specificity in the diagnosis of malignant colo-rectal neoplasms. The major drawback of NBI is that images become dark in the presence of blood and fecal matters. The bright-NBI is a prototype imaging technology that enables endoscopists to obtain better images in suboptimal conditions. The study proposes to compare the performance of colonoscopy using either white light or bright NBI in subjects undergoing screening colonoscopy in search for colon adenomas.

Purpose

To determine that bright -NBI is superior to WLE in detecting colorectal adenomas in average risk subjects undergoing screening colonoscopy.

Removal of colorectal adenomas prevents occurrence of cancers \[1\]. It is recognized that colonoscopy can miss colorectal adenomas and early cancers \[2\]. There is a need to further improve performance of colonoscopy. The use of chromo-endoscopy has been shown to improve detection of flat adenomas \[3\]. Narrow band imaging was introduced in year 2006. It is similar to chromo-endoscopy in that it provides more mucosal details. This enables endoscopists to accurately describe the pit pattern of adenomas. NBI has been used as a substitute to chromo-endoscopy. In pooled analysis, NBI is comparable to chromo-endoscopy in their sensitivity and specificity in the diagnosis of malignant colorectal adenomas \[4\]. Unfortunately, the use of NBI has not been shown to conclusively improve rate of colorectal adenoma detection. Two of 3 randomized trials that compared WLE to NBI showed a higher adenoma detection rate with the use of NBI \[5, 6\]. In a study by Rex et al., the rate was however similar with either modality. In a pooled analysis, NBI was only marginally better than WLE \[4\].

The effective use of NBI depends on the quality of bowel preparation and the experience of endoscopist. In the presence of fecal matters, NBI tends to be dark and detection of small adenomas becomes difficult. The prototype bright NBI coupled with high definition resolution is likely to overcome this drawback of original NBI.

Eligibility Criteria:
Inclusion Criteria:

1. Asymptomatic subjects undergoing screening colonoscopy
2. age \> 40
3. average risk subjects defined as those without a personal history of inflammatory bowel disease, colon adenoma or cancer or family history of Familial adenomatous polyposis (FAP) or Familial non-polyposis syndrome or first degree relatives having diagnosed to have colo-rectal carcinoma
4. no colonoscopy in past 5 years
5. ability to provide a written consent to trial participation

Exclusion Criteria:

1. Patient age \< 50
2. Patients with prior colorectal surgery
3. Pregnant or lactating women
4. Colonoscopy done within the past 5 years
5. Lack of consent
Effect of CRRT Duration on Solute Removal

The only FDA approved treatment for acute kidney injury(AKI) for patients is Dialysis-also known as renal replacement therapy(RRT). Continuous RRT(CRRT) is the preferred method in the ICU. Patients receiving CRRT with AKI will be recruited to the study where blood and effluent will be collect prior to CRRT initiation and Day 1,2,and 3 following. Metabolites will be assessed to determine solute removal, and also to identify the time at which solute removal has reached steady state. This will help determine the best duration of CRRT.

Acute kidney injury (AKI) occurs in 30-50% of hospitalized patients admitted to the intensive care unit (ICU). Dialysis - also known as renal replacement therapy (RRT) - is the only FDA approved treatment for AKI and continuous RRT (CRRT) is generally the preferred method of RRT in the ICU. The in-hospital mortality of patients with AKI requiring dialysis in the ICU is over 50% which is much greater than other serious illnesses.Unfortunately, the quality of care delivered to patients with AKI receiving CRRT is poor due to practice variability and lack of quality indicators to assess CRRT performance. Since one of the fundamental purposes of CRRT is to remove the build-up of metabolites that accumulate during AKI, accurate methods to assess solute clearance would be especially valuable. Indeed, development of methods to assess solute clearance during CRRT has been identified as a research priority. Although changes in plasma creatinine has been suggested as a potential quality indicator of solute removal during CRRT, no study has assessed how reductions of plasma creatinine over time compare to the reductions of other plasma metabolites. Thus, the duration of CRRT necessary to achieve adequate solute removal is unknown - in fact, there is not yet even an agreed-upon working definition of what adequate solute removal during CRRT should be. The investigators propose to conduct a prospective, single center study of 112 CRRT patients to determine the effect of CRRT duration on solute removal in order to identify the time at which solute removal has reached steady state. To assess solute removal, 102 metabolites will be determined in the plasma and effluent via untargeted ultra high pressure liquid chromatography coupled to mass spectrometry (UHPLC-MS). Metabolites will be assessed on plasma collected immediately prior to CRRT initiation, and on plasma and effluent collected on days 1, 2, and 3 post-CRRT initiation. Steady state is defined as the time point at which a plasma metabolite is not significantly reduced during CRRT - as assessed over a 24 hour time period. Based on preliminary data, the investigators hypothesize that \>90% of metabolites will reach steady state by day 2 of CRRT, and that \>95% of metabolites will reach steady state by day 3 of CRRT.

Eligibility Criteria:
Inclusion Criteria:

* All adult patients being initiated on CRRT at University of Colorado Hospital (UCH) will be considered for enrollment.

Exclusion Criteria:

* Vulnerable populations such as children, pregnant women, and prisoners will be excluded.
The Effects of Acetaminophen on Fear

This study investigates the effects of acetaminophen on behavioral, physiological, and self-report fear responses.

As acetaminophen blunts the experience of physical, social, and empathic pain, it is important to investigate whether there are other aversive states that the drug also provides relief from. If there are others, this may suggest overlapping mechanisms involved in these affective evaluations, all of which are interrupted by acetaminophen. The emotion of fear is aversive, yet it is distinct from both physical and social pain.

The present study will investigate the effects of acetaminophen on the subjective experience of fear as well as its behavioral outcomes. While blocking adaptive behavioral responses to fear could potentially be problematic in some dangerous situations, it may also be helpful for those with anxiety-related disorders. If individuals on acetaminophen can step farther away from safety on a virtual plank 80 stories above the ground, then perhaps acetaminophen can allow anxious individuals to step farther from their comfort zone in real life. Importantly, if acetaminophen blunts the fear response, this would mean that the drug blocks aversive feelings beyond emotional and physical pain. The extent of its effects will warrant further investigation for a greater understanding of emotional evaluations.

Eligibility Criteria:
Inclusion Criteria:

* 18 years or older
* Literate
* Speaks English
* Does not have any risk factors associated with acetaminophen (history of liver or kidney disease, taking other products with acetaminophen, has any allergies to acetaminophen, taking blood-thinning medications, drinks more than 12 alcoholic drinks per week for females, or more than 15 alcoholic drinks per week for males, are/ could be pregnant)
* Has taken acetaminophen in the past without any adverse reactions
* Is not diabetic
* Did not have anything to eat within three hours of study time
* Did not have any acetaminophen or alcohol in the 48 hours prior to study
* Has never had an adverse reaction to virtual reality before, such as headaches or nausea

Exclusion Criteria:

* Younger than 18
* Non-literate
* Does not speak English
* Has at least one risk factor associated with acetaminophen (history of liver or kidney disease, taking other products with acetaminophen, has any allergies to acetaminophen, taking blood-thinning medications, drinks more than 12 alcoholic drinks per week for females, or more than 15 alcoholic drinks per week for males, are/ could be pregnant)
* Has never taken acetaminophen before
* Diabetic
* Had something to eat within three hours of scheduled study time
* Has had acetaminophen or alcohol in the past 48 hours
* Has had an adverse reaction to virtual reality in the past, such as headaches or nausea
Reliability and Cross-cultural Adaptation of the Turkish Version of the Neuropathic Pain Symptom Inventory

In this study, investigators want to perform the reliability and cross-cultural Adaptation of the Turkish Version of the Neuropathic Pain Symptom Inventory

The purpose of the study is to determine the Turkish version, the reliability and cross-cultural Adaptation of the Turkish Version of the Neuropathic Pain Symptom Inventory. 120 patients with neuropathic pain will be included in the study. Test-retest and internal consistency analysis were conducted to determine the reliability of the questionnaire. Test-retest results evaluated using the Intraclass Correlation Coefficient method.

Eligibility Criteria:
Inclusion Criteria:

* Age upper 18
* Complaints of neuropathic pain for at least 3 months

Exclusion Criteria:

* Presence of psychiatric illness
* Cancer pain, unsuccessful lumbar surgeon syndrome etc. mix type pain presence
* Presence of complex regional pain syndrome
* Cognitive impairment (mini-mental test score \<24)
* Native language is not Turkish
High Frequency Deep Sclerotomy (HFDS) ab Interno a Combination Surgical Intervention Using Cataract Surgery to Lower IOP

Objective:

To compare intraocular pressure lowering effect of combined sclerotomy ab interno with phacoemulsification and phacoemulsification alone, in primary or secondary open angle glaucoma patients.

Study design:

Prospective, randomized, case- control interventional surgical trial


Eligibility Criteria:
Inclusion Criteria:

Patients suffering from primary open-angle glaucoma (POAG) inadequately controlled with maximum tolerated medical therapy and who will be treated with cataract surgery.

Exclusion Criteria:

* One eyed patients
* Unwilling or unable to give consent, unwilling to accept randomization, or unable to return for scheduled protocol visits
* The presence of extreme narrow angle with complete or partial closure in either eye, except for occludable angles treated with a patent iridectomy
* Any abnormality preventing reliable applanation tonometry, any opacity or patient uncooperativeness that would restrict adequate examination of the ocular fundus or anterior chamber of either eye
* The risk of visual field or visual acuity worsening as a consequence of participation in the trial, in the investigator's opinion
* Any clinically significant, serious, or severe medical or psychiatric condition; any condition that, in the investigator's opinion, would interfere with optimal participation in the study or present a special risk to the patient
* Participation in any other investigational study within 30 days prior to baseline visit
Interest of Tracheal Extubation in Positive Pressure on Postoperative Oxygenation in Adult Digestive Surgery: Prospective Randomized Study ExPress

Evaluation of a postoperative tracheal extubation protocol under positive pressure in accordance with international recommendations.

Two arms: the first with "classic" extubation with disconnection of the respirator and the second with extubation without disconnection of the respiratory, as recommended.

Computer Randomization with a 1: 1 ration


Eligibility Criteria:
Inclusion Criteria:

* Age\> 18 and \<80
* Patient going to benefit from general anesthesia with orotracheal intubation for surgery lasting more than 60 minutes at the visceral surgery unit of the Rouen University Hospital.
* Person affiliated to a social security scheme
* Person who has read and understood the newsletter and signed the consent form

Exclusion Criteria:

* Minor patients or age\> 80 years
* History of Obstructive Sleep Apnea Syndrome
* Chronic respiratory failure / History of chronic obstructive pulmonary disease
* Surgery \< 60 minutes
* Use of methylene blue intraoperatively
* Extubation finally performed in the operating room
* orotracheal intubation difficult to induce general anesthesia
* Suspected inhalation during orotracheal intubation
* Pneumothorax per operative
* Heart failure authenticated by trans thoracic ultrasound \<50%
* Neuromuscular pathologies (myasthenia gravis, myopathies)
* Body mass index\> 35
* Emergency surgery
* Patient with an ASA IV score (ie according to the definition of the American Society of Anesthesiology)
* Major surgical complications (hemorrhagic shock)
* Major anesthetic complications (anaphylactic shock, bronchospasm)
* Pregnant or parturient or lactating woman or woman of childbearing age without proven contraception
* Person deprived of their liberty by an administrative or judicial decision or person placed under the protection of justice / guardianship or curatorship
Physiological and QoL Benefits of Qi-Gong in Post-acute Sequelae of Covid-19

The goal of this clinical trial is to determine whether Qi-Gong can improve physiological function and quality of life (QoL) in individuals with post-acute sequelae of SARS-CoV-2 infection (PASC).

Study Objectives:

To assess whether Qi-Gong improves physiological function in individuals with PASC.

To evaluate whether Qi-Gong enhances quality of life in individuals with PASC.

Study Design:

If a comparison group is included, researchers will compare Qi-Gong with standard care to assess its effectiveness.

Participant Involvement:

Practice Qi-Gong three times per week for three months. Record physiological data monthly.


Eligibility Criteria:
Inclusion Criteria:

* PASC
* above 20 y/o

Exclusion Criteria:

* Those who cannot cooperate
* Severe schizophrenia
Effect of Exercise Intensity on Vitamin D

Children with Down's syndrome (DS) are more liable to vitamin D deficiency. Treating this deficiency with supplements is associated with the risk of intoxication due to increased intestinal absorption or decreased vitamin D metabolism. The aim of the study was to compare the effect of two exercise intensities on the modulation of vitamin D and Parathormone (PTH) levels in children with DS.

Forty-four DS male children aged from 8-12 years participated in the study. The subjects were assigned randomly into two equal groups. group I received high-intensity treadmill aerobic exercises (T-AE) and group II received moderate-intensity T-AE, three times per week for three months. the blood samples were collected from both groups before the intervention, after one month of intervention, then after three months of intervention to assess serum 25(OH)D and PTH levels.

Eligibility Criteria:
Inclusion Criteria:

* all subjects were trainable and able to walk freely without assistance.
* Had vitamin D deficiency, the serum level of 25-hydroxyvitamin D (25(OH) D) was ranged from 10-20ng/mL.
* Did not take calcium or vitamin D3 supplements, medications for osteoporosis, antiepileptic drugs, or any medications that may affect the vitamin D metabolism in the last 5 months.
* The feeding method during the first two years of age for all children was bottle feeding.
* Mild to moderate mentally retarded, (IQ ranged from 45-70) to be able to understand and obey simple orders.
* free from any medical consequences for example cardiopulmonary disorders, auditory defects, and visual impairments.
* Had no previous history of strength training.
* Body mass index percentile ranged from the 50th percentile to less than the 75th percentile (healthy).
* The feeding method was by mouth with no special diet, with an absence of signs of malnutrition

Exclusion Criteria:

* autoimmune disease.
* Renal diseases.
* Have taken any thyroid medications.
* Obesity.
* epileptic fits.
First Line Prevent Age Study

To prove the effectiveness of complex wellness programs in terms of maintaining active longevity, including motivational counseling, high-intensity training, intermittent fasting, hypoxic training, as well as practices for achieving healthy sleep and mental well-being.

Clinical-instrumental, single-centre, prospective, open-label, non-randomized, sequential enrollment study with blinded endpoint analysis


Eligibility Criteria:
Inclusion Criteria:

* Men and women over 18;
* No significant (affecting the functional state) "active" diseases: acute diseases and exacerbations of chronic diseases;
* Interest in active longevity and willingness to participate in research.
* Signed informed consent.

Exclusion Criteria:

* Age up to 18 years;
* Severe or moderate comorbidities;
* Rheumatological (systemic / autoimmune) diseases of any severity;
* Intestinal infections (within 3 months);
* SARS / pneumonia, other diseases accompanied by systemic inflammation during the last 2 months;
* Chronic inflammatory bowel disease;
* Major surgery within the last 3 months
* Intoxication (alcohol, drugs, other toxins);
* Oncological disease (except for basalioma) out of remission;
* Persons with mental illness;
* Diabetes;
* Syndrome of obstructive sleep apnea of moderate and severe severity;
* Low adherence to lifestyle interventions, including physical activity of less than 150 minutes of aerobic activity per week (at least two days per week) or 75 minutes of vigorous exercise (at least 3 days per week).
Glycaemic Response, Insulinaemic Response, GLP-1 and GIP Testing of Food Product Lines

The aim of this study was to compare the glycaemic response, insulinaemic response, GIP response and GLP-1 response to glucose, 25 g Nutralys S85 Plus and 50 g Nutralys S85 Plus using a single-blind, randomised, repeat measure, crossover design trial.

The aims of this study were to examine:

* Phase I - the glycaemic response (GR) and insulinaemic response (IR) to:

  * 50 g available carbohydrate
  * 50 g available carbohydrate + protein (dose 1)
  * 50 g available carbohydrate + protein (dose 2)
* Phase II - the GLP-1 and GIP response to:

  * 50 g available carbohydrate
  * 50 g available carbohydrate + protein (dose 1)
  * 50 g available carbohydrate + protein (dose 2)

A single-blind, randomised, repeat measure, crossover design trial was used to study the response following consumption of three meals: one reference meal (50 g available carbohydrate) and two test meals (50 g available carbohydrate with protein dose 1 and 50 g available carbohydrate with protein dose 2). The study was conducted in two phases:

* Phase I: glycaemic response (GR), insulinaemic response (IR)
* Phase II: GLP-1 response and GIP response

Eligibility Criteria:
Inclusion Criteria:

* Aged 18 to 60 years
* Body mass index (BMI) less than 30kg/m2

Exclusion Criteria:

* Pregnant or lactating
* Fasting blood glucose value \> 6.1 mmol/l
* Any known food allergy or intolerance
* Medical condition(s) or medication(s) known to affect glucose regulation or appetite and/or which influence digestion and absorption of nutrients
* Known history of diabetes mellitus or the use of antihyperglycaemic drugs or insulin to treat diabetes and related conditions
* Major medical or surgical event requiring hospitalization within the preceding 3 months
* Use of steroids, protease inhibitors or antipsychotics (all of which have major effects on glucose metabolism and body fat distribution).
* Unable to comply with experimental procedures or did not follow GR testing safety guidelines.
Transversus Abdominis Plane Block Versus Ilioinguinal Nerve Block for Pain Management in Inguinal Herniorraphy

This study compares efficacy of transversus abdominis plane block and ilioinguinal nerve block for postoperative pain in patients undergoing inguinal herniorraphy with spinal anesthesia. One-third of the patients will receive standard postoperative pain regimen(control group), one-third will receive a transversus abdominis plane block (with ultrasound guidance) and the last group will receive an ilioinguinal nerve block(with ultrasound guidance) in addition to standard postoperative pain regimen. This study is a Randomized prospective open-label controlled study.


Eligibility Criteria:
Inclusion Criteria:

* patients over 18 years old
* having ASA (American Society of Anesthesiologists) 1 or 2 physical status score preoperatively
* not having a neuromuscular disease
* scheduled for elective single sided inguinal herniorraphy operation

Exclusion Criteria:

* being under 18 years of age
* patient refusal
* having a neuromuscular disease or sensorial neurological deficit covering similar area of effect with peripheral nerve block interventions or the surgical site
* having ASA 3 or 4 physical status score preoperatively
* having one of the contraindications to spinal anesthesia and/or to peripheral nerve blocks as listed by NYSORA (New York School of Regional Anesthesia)
* having emergency surgery or scheduled for bilateral inguinal herniorraphy
Could Algometric Assessment be Effective to Adjust Postoperative Analgesic Requirement?

The purpose of this study is to determine the correlation between preoperative algometer score and the amount of postoperative analgesic consumption. The algometer score of the patients will be recorded in the preoperative period. In postoperative period, the analgesic consumption rate will record and compare with the algometer score.

The aim of this study is to define the correlation between preoperative algometer score and the analgesic consumption rate. A total of 80 patients whose undergo septoplasty or septorhinoplasty will be included in this study. After preoperative examination, a positive pressure using algometer device will be performed until minimal pain is felt. In postoperative period, the amount of analgesic consumption of the patient will record and compare with the algometer score.

Eligibility Criteria:
Inclusion Criteria:

* Patients those undergo septoplasty or septorhinoplasty

Exclusion Criteria:

* Hypertension
* Diabetes mellitus type 1 or 2
* Continuous use of analgesics
* Patients whose do not accept to participate in the study
* Patients those reoperated for bleeding