cyrilzakka/clinical-trials huggingface dataset:
Effects of Qigong Sensory Training on Sensory Modulation and Behavior in Children With Autism

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social interaction, communication, and a range of repetitive behaviors. Among these challenges, sensory processing abnormalities are highly prevalent, manifesting as hyper- or hypo-sensitivity to sensory stimuli, and can significantly impact daily functioning and quality of life. In sensory modulation there are difficulties in regulating and responding appropriately to sensory input from the environment. Sensory modulation can have a significant impact on the daily lives of individuals with autism, affecting their ability to engage in various activities and navigate social interactions. Autistic children also have repetitive behaviors, such as repetitive actions like self-stimulation behavior, or stimming. These behaviors can involve one part of the body, the entire body or an object. QST in which deep pressure with thumb apply on head, neck, trunk and limbs along deep breathing which give relaxation to body and have effect on sensory modulation and behavior in children with Autism. The intended project aims to evaluate the sensory modulation and behavior in children with autism spectrum disorder (ASD) through Qigong Sensory Training (QST).

A quasi-Experimental study will be conduct to evaluate the effect of QST on the sensory modulation and behavior of autistic children. 21 Participants will be included in the study with age of 4-12 years diagnosed with ASD. Participants will be received 15 mints massage therapy 2 times in a day and 5 days a week for 8 weeks. Before and after 8 week of intervention, Assessment of sensory modulation scale (ASMS) will be used to check the sensory modulation level and strength and difficulties questionnaire (SDQ) will be used to check the behavior. Data will be collected from Nishtar Hospital Multan. The pre and post intervention assessments will be done. The reliability and validity of tools are mentioned. The duration of study will be 10-months. Data will be analyzed with the help of SPSS 25.


Eligibility Criteria:
Inclusion Criteria:

* Children aged 4 to12 years diagnosed with autism spectrum disorder.
* Male and Female will be included in study.
* Parental/guardian consent to participate in the study.
* Children do not receive any other intervention therapy during study

Exclusion Criteria:

* Children with severe physical disabilities that significantly impair their ability to participate in touch-based interventions, as determined by a qualified healthcare provider.
* Children diagnosed with severe psychiatric conditions other than autism spectrum disorder (ASD), including but not limited to schizophrenia, bipolar disorder, and severe anxiety disorders.
Effect of Static Magnetic Field on Dental Implant Stability.

To evaluate the effect of static magnetic field on dental implant to bone integration.

Bone to implant integration depend on bone healing. Magnetic field was proved to promote and make bone to implant integration happen faster. We decided to investigate by placing 2 dental implants in lower jaw of complete edentulous patients with specialised temporary dentures. Said denture will have neodymium magnet on one side, completely embedded in acrylic mass.

Eligibility Criteria:
Inclusion Criteria:

* healthy, complete edentulous area

Exclusion Criteria:

* uncontrolled NCDs patients
An Open Label Study of L059 Intravenous (IV) in Japanese Epilepsy Subjects With Partial Onset Seizures

To evaluate the safety of Levetiracetam IV 15-minute infusion administered every 12 hours as adjunctive treatment in subjects with Partial Onset Seizures after switching from the equivalent Levetiracetam oral dose.


Eligibility Criteria:
Inclusion Criteria:

* Subject is a male or female aged ≥ 16 years
* Subject has Partial Onset Seizures that are classifiable according to the 1981 International League Against Epilepsy (ILAE) classification of Epileptic Seizures
* Subject weighs ≥ 40 kg
* Subject is currently taking Levetiracetam (LEV) as an adjunctive antiepileptic oral treatment with 1 to 3 other Antiepileptic Drugs (AEDs)

Exclusion Criteria:

* Subject has problems with venous accessibility
* Subject has participated in another clinical/pharmacological study during the last 4 weeks prior to the Screening Visit
* Subject is pregnant or lactating
* Subject has a history of suicide attempt(s) or presents with current depressive signs, current suicidal ideation, and/or behavior
* Subject has clinically significant Electrocardiogram (ECG) abnormalities according to the investigator
Risk Factors for Community- and Workplace Transmission of COVID-19

The project is an epidemiological observational study based on an electronic questionnaire on risk factors for COVID-19 in the community and healthcare setting.

Summary The data collected will identify real-life risk factors for getting the COVID-19 diagnosis.

The Oslo University Hospital/University of Oslo web-based solution "nettskjema" will be used to collect data and consent forms.

The impact of knowing the risk factors for COVID-19 is tremendous because it can enable governments to conduct more targeted public health measurements than today to reduce the spread of the virus.

Detailed description Research into an ongoing COVID-19 outbreak is difficult because patients are isolated, and supplies of personal protective equipment (PPE) supplies are limited. The risk of transmission to study personal is non-negligible even when PPE is available.

A study design based on an electronic questionnaire and consent from delivered from the Oslo University Hospital/University of Oslo, GDPR (General Data Protection Regulation) compliant "TSD" service has therefore been chosen.

The study will be a case-control study based on a combined electronic consent form and questionnaire that the participants will fill in using a smartphone and electronic identification.

The groups that will be included are:

* Hospitalized and non-hospitalized patients/persons with COVID-19 at all stages of the disease and after the disease
* Hospitalized patients without COVID-19
* Healthcare personal or other groups with an increased risk of COVID-19
* Healthy volunteers

Participants may be followed with repeated questionnaires prospectively.

Biological samples Biological samples may hold crucial information about the susceptibility to COVID-19 and for susceptibility to the progression of the disease. It is within the scope of the study to analyze such samples from a limited number of participants which will be asked to provide such samples or hospitalized patients that have surplus material. The material will be analyzed with non-genetic methods most suitable to provide such information.

Eligibility Criteria:
Inclusion Criteria:

* Norwegian adult

Exclusion Criteria:

* Unable to consent
Inherited Susceptible Genes Among Epithelial Ovarian Cancer

Purpose: To investigate the prevalence of the germline mutations in the BRCA 1/2 and mismatch repair genes in patients with epithelial ovarian cancer (EOC) and their relatives, and related somatic mutations in tumor tissues in the northern part of china.

Patients and methods: A multicenter prospective study will be hold in the northern part of china form 2017. About 1000 female patients with epithelial ovarian cancer and their ralatives will be tested for germline mutations in the BRCA 1/2 and mismatch repair genes and related somatic mutations in tumor tissues, regardless of the family history.

Study type: Observational Official title: Prevalence study of germline mutations in susceptibility ovarian cancer genes in patients with epithelial ovarian cancer and somatic mutations in their tumor tissures in the northern part of china.

Enrollment: 1000


Eligibility Criteria:
Inclusion Criteria:

1. epithelial ovarian cancer and their relatves
2. living in the north of Huaihe River in China
3. being Han Chinese

Exclusion Criteria:

1. non-epithelial ovarian cancer
2. without specific pathological diagnosis
3. non-Han Chinese
Serratus Plane Block for the Prevention of Chronic Pain After Breast Cancer Surgery

This study compare the "Serratus block plane" (SPB) and the local infiltration of the tissue in the prevention of acute and chronic pain after breast cancer surgery.

Chronic pain after breast surgery may be severe, often requiring the use of morphine. The incidence of chronic pain varies from 27 to 50% depending on definitions.

The infiltration of tissues by a local anesthetic is a simple, fast and low risk technique but of limited effectiveness.

Serratus the flat block, performed under ultrasound guidance, is minimally invasive and easy to perform. It allows anesthesia and analgesia to an extended part of the anterolateral chest wall and the axilla. This regional anesthesia technique provides good analgesia during and after breast surgery, but remains to be evaluated; beyond perioperative analgesia, the benefit-risk, post operative rehabilitation, and the impact on ambulatory and on chronic pain are fundamental objectives.

Eligibility Criteria:
Inclusion Criteria:

* Women scheduled for elective breast neoplasm surgery
* Of ASA classification 1, 2 or 3
* Patients who provide written informed consent

Exclusion Criteria:

* Minor patients
* Patients refusing to sign the consent
* Patients included in another protocol within 3 months
* Pregnant or lactating patients
* Patients with history of allergy to local anesthetics (Ropivacaine)
* Patients with contraindication to regional anesthesia (coagulopathy, local infection ...)
* Patients with history of prior breast surgery (excluding diagnostic biopsy)
* Patients with history of chronic pain
* Patients with a history of psychiatric disorder
Identifiable Factors That May Lead to Postoperative Nausea and Vomiting After Simple Laparoscopic Appendectomy

This is a retrospective chart review meant to identify any factors that are correlated with and may possibly lead to postoperative nausea and vomiting in order to predict need for longer hospital stays and potentially decrease postoperative nausea and vomiting.


Eligibility Criteria:
Inclusion Criteria:

* Laparoscopic Simple Appendectomy
* Uncomplicated surgery

Exclusion Criteria:

* None
Changes in Brain Tissue Pulsatility With Musical Stimuli

Music Perception is well known to elicit emotions and neuronal activations. Changes in the cerebrovascular physiology have also been found in emotional tasks but only few studies have investigated markers of cerebrovascular physiology in a music task and no study has used the Ultrasound method of Tissue Pulsatility Imaging (TPI) in a music task. The use of TPI to measure reactivity of Brain Tissue Pulsatility Imaging (BTP) could further elucidate the cerebral basis of music perception.


Eligibility Criteria:
Inclusion Criteria:

* more or equal 18 years-old and less or equal 45 years-old
* no known hearing problem

Exclusion Criteria:

* professional musician
* history of neurologic, psychiatric or cadiologic disease
* treatment which could impact parameters of brain tissue pulsatility and peripheral nervous system
* opposition to use the data
Evaluation of Early Discharge After Cesarean Section

The rate of cesarean delivery is increasing, in developing countries, its rate ranges from 13 to 47% of all cases of delivery. This huge volume of cesarean deliveries has a great financial burden on the healthcare system. Rising hospital costs have led to the implementation of an early discharge policy after surgeries.

Cesarean section (CS) is the most commonly performed surgical procedure worldwide that effectively prevents maternal and newborn mortality when used for medically indicated reasons. Compared with vaginal delivery, however, the procedure is associated with a higher risk of various maternal complications, such as maternal infection and subsequent pregnancy complications, and a higher likelihood of re-hospitalization within six weeks of delivery. Furthermore, the likelihood of maternal morbidity increases for mothers who repeatedly undergo cesarean delivery. CS typically implies a hospital stay for two to three days, whereas parous women are often discharged within a few hours after an uncomplicated vaginal birth. However, the period after CS includes recovery from surgery as well as adapting to motherhood.

According to World Health Organization, the cesarean section rate will increase to 28.5% of total live births by the year 2030. This huge volume of cesarean deliveries and increasing cesarean section rate has an incremental burden on the healthcare system, leading to higher bed occupancy and financial pressure on the patients and health facilities. Postpartum stay at hospitals is steadily declining in the UK and other countries due to cost savings. Rising hospital costs are one of the factors in early discharge.

According to The American College of midwifery and gynecology, earlier discharge is a choice if the baby is ready to go home, though, the mother should have basic requirements such as normal blood pressure, no symptoms of infection, and adequate pain control. Also, the National institute for health and care excellence (NICE) guidelines recommend "women who are recovering well, are apyrexial and do not have complications following Caesarean Section should be offered early discharge (after 24 hours) from the hospital and follow up at home.

Eligibility Criteria:
Inclusion Criteria:

* BMI ≤ 35 kg/m2
* Gestational age at delivery from 37 0/7 to 42 0/7 weeks of gestation
* Uncomplicated pregnancy
* Cesarean section under spinal anesthesia with no intra-operative complications
* Uneventful postoperative course

Exclusion Criteria:

* Complicated pregnancy (Multiple pregnancies, Polyhydramions, Abnormal placenta, Premature rupture of membranes).
* Medical disorders (diabetes, hypertension, cardiac, renal, endocrinological disorders).
Aerobic Training in Pregnant Women With Gestational Diabetes and Chronic Hypertension

The aim of the present study is verify glycated hemoglobin (HbA1c) and HOMA behavior in pregnant women with gestational diabetes or chronic hypertension after an aerobic training in cycle-ergometer. The sample is composed by 64 pregnant and sedentary women, 20 weeks' pregnant.

Two experimental groups (gestational diabetes and chronic hypertension, n = 16 each) will perform a low-intensity aerobic training in cycle-ergometer, three times/week, for 45 minutes each session. Two control groups (gestational diabetes and chronic hypertension, n = 16 each) will perform an unique session/week of relaxation and stretching.

Outcomes: first ventilatory threshold, HbA1c,HOMA, type of delivery, weight and height of the newborn.

The statistical analysis will consist of:

* descriptive statistic;
* Levene's test
* Shapiro Wilk's normality test
* Parametric or non-parametric test
* a=0.05
* SPSS 17.0

Eligibility Criteria:
Inclusion Criteria:

* age \> 20 years;
* gestational age between 20 and 27 weeks (date of the last period and confirmed by ultrasound);
* Only one foetus in the womb;
* Without orthopedic limitations;
* Non-smoker;
* Medical clearance for exercise

Exclusion Criteria:

* Pre-eclampsia;
* fetal malformations;
* Intrauterine fetal death
Reducing Heart Failure Re-admissions by Enhancing Sleep Apnea Treatment Adherence

Sleep apnea, characterized by abnormal breathing at night, is often untreated in patients with heart failure. Helping patients to effectively use the most common form of treatment for sleep apnea, positive airway pressure therapy, can improve their heart function. This can reduce the likelihood that the patient will be re-admitted to the hospital. AirCareLabs has developed an innovative solution that allows patients to communicate with health care providers 24 hours a day, thus allowing them to get the help they need to effectively use positive airway pressure and thereby reduce the risk of being re-admitted to the hospital.


Eligibility Criteria:
Inclusion Criteria:

* Congestive heart failure and sleep apnea

Exclusion Criteria:

* Cognitive impairment
Predictors Associated With Seeking Orthodontic Treatment, Compliance and Treatment Success

Aim: to search for reasons for seeking orthodontic treatment, compliance during orthodontic treatment, drop-out from orthodontic treatment and success of orthodontic treatment.

Methods: evaluation before, during and at the end of orthodontic treatment. Clinical and diagnostic evaluation of complexity before and at the end of orthodontic treatment, evaluation of awareness of treatment need, impact on social and psychological aspects, functional disturbances, impact of malocclusion on quality of life, social interaction, ability to perform daily activities.

Data will include diagnostic measurements on study casts, x-rays, and data from questionnaires given to children and parents. Statistical analyses will explore predictors of treatment success with treatment need, compliance and psycho-social domains.

Eligibility Criteria:
Inclusion Criteria:

* distal molar occlusion, overjet \>5 mm, cervical vertebral maturation method stages (CS) -CS2, CS3 or CS4

Exclusion Criteria:

* mental retardation
First in Human, Single Ascending Dose Study

The goal of this study is to evaluate the safety and tolerability of single ascending oral doses of INV-101 in healthy adult subjects.


Eligibility Criteria:
Inclusion Criteria:

* Healthy, adult, male or female (of non-childbearing potential only), 19-55 years of age, inclusive, at the screening visit.
* Body mass index (BMI) ≥ 18.0 and ≤ 32.0 kg/m2 at the screening visit.

Exclusion Criteria:

* Mentally or legally incapacitated or had significant emotional problems at the time of the screening visit or expected during the conduct of the study.
* History or presence of clinically significant medical or psychiatric condition or disease in the opinion of the PI or designee.
Phase I Combination With Vinorelbine or Gemcitabine Plus Cisplatin in Locally Advanced or Metastatic NSCLC

To test the safety and tolerability of ZD6474 in combination withVinorelbine (Navelbine) or Gemcitabine (Gemzar) plus cisplatin as first line therapy in patients with locally advanced or metastatic (Stage IIIB-IV) Non Small Cell Lung Cancer.


Eligibility Criteria:
Inclusion Criteria:

* Confirmed non small cell lung cancer (stage IIIB-IV)
* Life expectancy greater than 12 weeks
* At least 1 measurable lesion greater than 10mm in smallest diameter.

Exclusion Criteria:

* Prior treatment with anticancer agent
* Brain metastases
* Major surgery within last 4 weeks
A Study to Evaluate BMS-986036 in Obese Adults With Type-2 Diabetes

The purpose of this study is to assess the potential of BMS-986036 for treatment obese adults with type-2 diabetes.


Eligibility Criteria:
For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com

Inclusion Criteria:

* Diagnosed with type-2 diabetes mellitus with HbA1c ≥6.5% to less than 10.0%
* Body mass index 30.0 to 50.0

Exclusion Criteria:

* Any significant acute or chronic medical illness
* Inability to self-administer subcutaneous injections
* Inability to be venipunctured
* Evidence of organ dysfunction beyond what is consistent with the target population
* History of allergy to PEGylated compounds or Fibroblast growth factor 21 (FGF21) related compounds
Sirolimus in Combination With MEC in High Risk Myeloid Leukemias

The purpose of this study is to evaluate the side effects of sirolimus (rapamycin) given in combination with chemotherapy (Mitoxantrone + Etoposide + Cytarabine (MEC)) on high risk myeloid leukemias.


Eligibility Criteria:
Inclusion Criteria:

* Must have histologic evidence of advanced myeloid leukemias defined as one of the following: primary refractory non-M3 AML; relapsed non-M3 AML; secondary AML; intermediate or poor prognosis de novo AML in patients who are \>= 60 years old
* \>= 18 years of age
* ECOG performance status of 0, 1
* Able to consume oral medication
* Initial laboratory values: creatinine \<= 2.0 mg/dL; total or direct bilirubin \<= 1.5/dL; SGPT(ALT) \<= 3xULN; negative pregnancy test for women with child-bearing potential
* Ejection fraction of \>= 45%

Exclusion Criteria:

* Subjects with FAM B3
* Must not be receiving chemotherapy (except Hydroxyurea)
* Not receiving growth factors, except for erythropoietin
* Subjects with a "currently active" second malignancy other than non-melanoma skin cancers
* Subjects with uncontrolled high blood pressure, unstable angina, symptomatic congestive heart failure, MI within the last 6 months or uncontrolled cardiac arrhythmia
* Subjects taking diltiazem
* Subjects who require HIV protease inhibitors or those with AIDS-related illnesses
* No evidence of cerebellar dysfunction at baseline or during prior cytarabine therapy
* Not pregnant or breastfeeding
* Uncontrolled infection
* Subjects taking Carbamazepine, Rifabutin, Rifampin, Rifapentine, St. John's wort, Clarithromycin, Cyclosporine, Diltiazem, Erythromycin, Telithromycin, Verapamil, Tacrolimus
Evaluation of the Effect of Preoperative Intravenous Amantadine Sulfate on the Postoperative Early Cognitive Functions in a Elderly Patient With Laparoscopic Radical Prostatectomy

Evaluation of the effect of preoperative intravenous administration of amantadine sulfate on the prevention of the development of early cognitive dysfunction in elderly patients undergoing laparoscopic radical prostatectomy

Investigators believe that the preoperative prophylactic amantadine sulphate will reduce the incidence of postoperative cognitive disfunction (POCD) in patients with laparoscopic radical prostatectomy due to the neuroprotective effect, alertness enhancing effect and neuron protective effects.

Eligibility Criteria:
Inclusion Criteria:

- ASA II-III Patient

Exclusion Criteria:

* history of disease related to central nervous system, history of psychiatric disease, history of previous open heart surgery, history of previous craniotomy, renal insufficiency, hepatic failure, history of arrhythmia pre-applied standardized Mini Mental Test (sMMT) less than 24 points
Protein Supplementation and Weight Loss

This randomized control trial of diet with protein supplementation is being conducted to test the hypothesis that in overweight/obese subjects high protein diet may lead to weight loss and improvement in cardio-metabolic profile.


Eligibility Criteria:
Inclusion Criteria:

1. Subjects aged between 21 -65 years
2. Subjects with BMI \> 23 Kg/m2

Exclusion Criteria:

* Inclusion Criteria:

  1. Subjects aged between 21 -65 years
  2. Subjects with BMI \> 23 Kg/m2

Exclusion Criteria:

1. Diabetes (type 1 and type 2)
2. Known or documented coronary heart disease (CHD) (including ECG consistent with prior myocardial infraction), cerebrovascular accident (including transient ischemic attack), peripheral vascular disease (including symptoms of claudication)
3. Angina or other chest pain that may indicate CHD by history
4. Clinically significant neoplastic, cardiovascular, hepatic, renal, metabolic, endocrine (untreated or unstable), or psychiatric (untreated or unstable) by history
5. Medications: Lipid lowering therapy, daily NSAID or greater than 325 mg ASA (PRN use ok), clopidogrel (or equivalent), Coumadin, other investigational drugs within 30 days of study entry
6. Pregnancy or planning pregnancy during the study period by history
7. Uncontrolled hypertension
8. Uncontrolled hypothyroidism
9. Sensitivity or allergy to product by history
10. Subjects who had undergone bypass procedure
11. Any debilitating disease such as tuberculosis, HIV by history .
12. Unwillingness to give written informed consent for participation in the study