Quercetin In The Treatment Of SARS-COV 2

In 1937, Albert Szent-Gyorgyi received a Nobel Prize for discovering vitamin C and flavonoids, as well as for exploring their biochemical properties. Originally, he gave the flavonoids the name "vitamin P" because of their effectiveness in reducing the permeability of blood vessels. This name was abandoned when it was realized that these substances were not really vitamins.

Quercetin is extracted from a variety of plant sources, including the onion peel and the seeds and pods of Dimorphandra mollis, a legume tree native to South America.

Although we are far from knowing everything about quercetin, its antioxidant, anti-inflammatory, and antihistamine (antiallergic) properties have been observed in numerous in vitro and animal studies.

Properties

* Anti-oxidant, vascular protector
* Inhibition of platelet aggregation, vasorelaxant , arterial relaxant
* Anti-hypertensive , especially by certain derivatives (quercetin-3-glucuronic acid)
* Nephroprotective in rats, protects against the nephrotoxicity of gentamicin
* Anticancer , with immunostimulatory activity and inducer of apoptosis, with activity on the shock proteins HSP (heat shock proteins) hsp27 and hsp70
* Antitumor activity against prostate cancer and certain breast cancer cells
* Prevention of cardiac toxicity from doxorubicin, with resveratrol
* Protection against gastric inflammation associated with Helicobacter pylori infection by activity on MAPK, BCL-2, BAX.
* Increases the antitoxic activity of the liver
* Pancreatic lipase inhibitor, potential action in weight gain
* Anti-inflammatory
* Anti-allergic, inhibition of mast cell degranulation, with a preventive effect, reduction of inflammation linked to eosinophils (such as isoquercitrin regulates the Th1 / Th2 balance
* Antiviral (dose-dependent reduction of infectivity, decreases intracellular replication)
* Inhibition of rhinovirus replication
* Influenza prophylaxis by quercetin or its derivatives (quercetin-3-O-α-L-rhamnopyranoside), opposes the pro-oxidant effects induced by the influenza virus, antioxidant therapy could be used to prevent serious complications associated with influenza
* In vitro inhibition of the penetration of the Ebola virus by quercetin-3-O-glucoside
* Antiviral activity against Zika virus, hepatitis B virus, hepatitis C, Epstein-Barr virus EBV and antitumor against human gastric carcinoma

Eligibility Criteria:
Inclusion Criteria:

* • Clinical score greater than 6

  * Patients with clinical symptoms less than 5 days old.
  * Men and women at least 40 years old, able and willing to give informed consent;
  * Any patient over the age of 18 with a CT scan in favor of COVID-19;
  * Ambulatory or hospitalized environment;
  * Patient with dyspnea or with a positive gait test;
  * The patient must have at least one of the following high risk criteria: 70 years or older, obesity (BMI ≥ 30 kg / m2), diabetes mellitus, uncontrolled hypertension (systolic blood pressure ≥ 150 mm Hg), respiratory disease known (including asthma or chronic obstructive pulmonary disease), known heart failure, known coronary artery disease, fever ≥ 38.4 ° C within the last 48 hours, dyspnea at the time of presentation, bicytopenia, pancytopenia or a combination of a number high neutrophils and low lymphocytes count;
  * The patient is not of childbearing age, defined as postmenopausal for at least 1 year or surgically sterile, or is of childbearing age and uses at least one method of contraception and preferably two complementary forms of contraception comprising a method of barrier throughout the study and for 30 days after the end of the study;
  * The patient must be able and willing to comply with the requirements of this study protocol.

Exclusion Criteria:

* • Patient currently in shock or exhibiting hemodynamic instability;

  * Patient with inflammatory bowel disease (Crohn's disease or ulcerative colitis), chronic diarrhea or malabsorption;
  * Pregnant or breastfeeding patient
  * Patient with a history of allergic reaction or significant sensitivity to Nigella;
  * The patient is considered by the investigator, for whatever reason, to be an unsuitable candidate for the study.