cyrilzakka/clinical-trials huggingface dataset:
Therapy Strategies After LAA Occluder Device Embolization

The investigators thought to evaluate risk factors, therapeutic approaches and outcomes after left atrial appendage occluder device embolization (LAAO, either surgical or interventional).

The global burden of atrial fibrillation (AF) is high, and AF represents a major cause of morbidity, mortality and health-care expenditure. Thromboembolic stroke may be one of the fatal complications and oral anticoagulation has been the mainstay therapy for decades to mitigate stroke risk. However, in poor candidates for long-term anticoagulation (i.e. high bleeding risk, poor drug tolerance or adherence), non- pharmacological stroke prevention with percutaneous left atrial appendage occlusion (LAAO) is a considerable treatment option.

Occluders are implanted into the left atrial appendage (LAA) but they might dislocate and therefore embolize subsequently. In this case, surgical or percutaneous removal of the device may be indicated. Depending on the patient's status, implanting another device can be an alternative to returning to anticoagulation.

Eligibility Criteria:
Inclusion Criteria:

* Patients after interventional or surgical left atrial appendage occlusion with device embolization

Exclusion Criteria:

* n/a
Effects of Social Media Addiction on Physical Activity Level and Exercise Capacity in University Students

The aim of this study is to investigate the effect of social media addiction on functional exercise capacity and maximal exercise capacity in university students.

The internet, one of the new communication technologies, has become an indispensable part of human life as it makes people's lives easier, provides people with the advantage of saving time, and facilitates and accelerates information acquisition.

Thanks to the internet, people can do many daily tasks quickly with minimal physical effort and cost. This makes personal and business life easier. Internet technology has many positive features. This network, which develops and changes daily, has become indispensable for many people. In addition to all these positive features, today, this situation emerges as a new addiction phenomenon. In cases where there is no parental or teacher supervision in their use of social media, adolescents encounter negative content.

There is a high probability of being affected by the contents. Sharing sites such as Facebook, Instagram, Twitter, Linkedin, YouTube, and Tumblr, which are very popular social media networks that have entered our lives, have been used by many people in the world and in Turkey for a long time. It seems that the rapid increase in usage rates and durations will continue rather than decrease.

The intense amount and duration of use brings the phenomenon of "addiction" to the agenda. People seek and express in virtual environments what they cannot achieve or express freely in real life. These types of actions increase people's usage time, So much so that this situation causes addiction. Many studies have been conducted in the literature to investigate the effect of social media and digital game addiction on physical activity levels. Although many studies have been conducted to examine social media addiction and the effects it causes, there is no research on the effects of social media addiction on functional exercise capacity and maximal exercise capacity. No study has been found investigating its effect. For this reason, the investigators think that there is a need for a study in this direction in the literature. The aim of this study is to investigate the effect of social media addiction on functional exercise capacity and maximal exercise capacity in university students.

Eligibility Criteria:
Inclusion Criteria:

* age between 18-30 years

Exclusion Criteria:

* chronic illnesses
* can't walk or run
Study of Atrasentan in Men With Non-Metastatic, Hormone-Refractory Prostate Cancer

This study is being done to evaluate the safety and efficacy of atrasentan in men with non-metastatic hormone-refractory prostate cancer.


Eligibility Criteria:
Inclusion Criteria:

* Have been diagnosed with prostate cancer.
* Have a rising PSA while on hormone therapy or following surgical castration.

Exclusion Criteria:

* Have evidence of distant metastatic disease on screening bone scan or CT scan.
* Have received cytotoxic chemotherapy.
* Have received opioid or narcotic medications (such as codeine or morphine) or radiation for pain caused by your prostate cancer in the last 6 months.
Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.


Eligibility Criteria:
Inclusion Criteria:

* 65-75 years of age

Exclusion Criteria:

* Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.
* Uncontrolled diabetes or hypertension.
* History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
* History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months
* Have a diagnosis of osteoporosis (as determined by DXA)
* Participated in a resistance or aerobic training program in the last 3 months
* Engage in more than 1 hr/week of vigorous activity
* Body mass index \>29
* On hormone replacement therapy
X-ray Dose Reduction Study for Cardiac Angiography and Intervention

ClarityIQ is a novel X-ray imaging technology, that combines advanced real-time image noise reduction algorithms, with state-of-the-art hardware to reduce patient entrance dose significantly. This is realized by anatomy-specific optimization of the full acquisition chain (grid switch, beam filtering, pulse width, spot size, detector and image processing engine) for every clinical task individually. Furthermore, smaller focal spot sizes and shorter pulses are used, which are known to positively influence image quality . The final effect on the clinical image quality is investigated in this study.

Fluoroscopically guided procedures are associated with a risk of radiation injury to the skin, caused by high peak skin dose. The increasingly complex nature of many of the interventions performed requires the use of significant amounts of radiation for their completion. Of particular relevance to dose reduction concerns are obese patients, for whom additional radiation is often necessary to obtained sufficient diagnostic quality, as well as patients suffering from chronic total coronary occlusions (CTO), for whom long procedures with extended radiation time and contrast usage are common.

In order to introduce a dose reduction technology the most important aspect is to validate the diagnostic image information. Philips has developed a new algorithm that is capable to process images with similar image quality but acquired at lower dose.

Eligibility Criteria:
Inclusion Criteria:

* Patients older than 18 years of age undergoing coronary angiography

Exclusion Criteria:

* Patients not willing or unable to give consent to participate
* Patients already involved in a clinical trial
* Patients under the age of 18
* Pregnant women and breastfeeding women
* Patients with severe kidney disease (eGFR \< 60)
PREEMPTİVE PARA-CERVİCAL BLOCK FOR POSTOPERATİVE PAIN AFTER LAPAROSCOPIC HYSTERECTOMY

Total hysterectomy is one of the most common surgical procedure in gynecology. The laparoscopic route for the performance of hysterectomies are on the rise \[1\]. The laparoscopic hysterectomy (TLH) procedure has several advantages over open surgery such as better cosmetic outcomes, faster recovery earlier return to normal activities and work \[1-3\]. Nonetheless, postoperative pain (PP) remains an issue that scuppers these advantages \[1-3\].

The incidence of PP after TLH has been reported to vary from 35% to 63% \[4,5\]. The origin of PP after laparoscopy is multifactorial and complex such as perioperative predicaments, including pneumoperitoneum, stretching of the intraabdominal cavity, the blood left in the abdomen, and dissection of the pelvic region \[6-7\]. A randomized controlled trial has demonstrated that there may be more intense pain and greater analgesia requirements in the immediate postoperative period after laparoscopic surgery than after laparotomy \[8\]. Further inquiry to intercept the advancement and decrease the severity of PP is prominent to further improve TLH.

Women undergoing TLH experience two different pain characteristics including incisional pain and visceral pain in the first hour after the operation \[6\]. These pains were most intense 30 min after TLH, gradually decreasing thereafter for postoperative 72 hr \[6\]. High levels of acute postoperative pain (APP) are pertain with an increment risk of chronic postsurgical pain so control of these acute pains in the urgent postoperative period is vital for faster amelioration.

Many attempts have been tried to control APP after THL, such as transverse abdominal plane blocks, superior hypogastric plexus block, local anesthetic injection to the port side, and reduced port caliber \[9-12\]. Para-cervical bloc (PCB) is believed to block the Frankenhouser nerve plexus that supplies the visceral sensory fibers to the uterus, cervix, and top of the vagina. Only two randomized studies have assessed the effect of PCB in THL, but several limitations such as the small sample size preclude drawing conclusions on PP after TLH. Thus, the primary goal of this randomized clinical trial was to investigate if PCB at the onset of surgery, as a part of enhanced recovery protocol, could improve patient recovery after THL.


Eligibility Criteria:
Inclusion Criteria:

-Patients undergoing total type A laparoscopic hysterectomy with or without additional surgery, such as salpingo-oophorectomy or salpingectomy

Exclusion Criteria:

* age \< 18 years
* refusal to provide consent
* inability to understand the study questionnaire
* severe psychiatric or mental disorder
* American Society of Anesthesiologists (ASA) physical status classification \> III
* history of regular narcotic use within 6 months of the surgery
* conversion to laparotomy
* operation time \> 90 min
* Additional procedures
PRINTO (the Paediatric Rheumatology International Trials Organisation)

A comparison of outcome in children with JIA who are in remission on MTX, when MTX is then stopped for either 6 or 12 months


Eligibility Criteria:
Inclusion Criteria:

* Any child with JIA who has gone into remission using methotrexate
n-3 Polyunsaturated Fatty Acids (PUFAs) in the Prevention of Atrial Fibrillation

The purpose of this study is to determine the effect of n-3 PUFAs in addition to amiodarone and renin-angiotensin-aldosterone system (RAAS) inhibitors on the maintenance of sinus rhythm after electrical conversion in patients with persistent Atrial fibrillation (AF).

Atrial fibrillation (AF) is the most common sustained arrhythmia and represents an increasing burden on the healthcare system. Treatment of AF remains controversial. In patients on antiarrhythmic therapy, the one-year relapse rates of AF after cardioversion ranges from 44% to 77% at one year and amiodarone appears to the be the most effective in maintaining sinus rhythm.Over the last few years, a growing amount of evidences has supported the protective effects of n-3 PUFAs in preventing ventricular arrhythmias and reducing the risk of sudden cardiac death. Furthermore, in the last years, the interest for their possible beneficial role in AF prevention has been increasing.We hypothesized that the administration of n-3 PUFAs could reduce the AF recurrence rate more than amiodarone plus RAAS inhibitors in patients with persistent AF. Therefore the present study aims to evaluate the role of n-3 PUFAs in the prophylaxis of AF recurrences after DCCV in addition to amiodarone and RAS blockers therapy in patients with persistent AF.

Eligibility Criteria:
Inclusion Criteria:

* persistent Atrial Fibrillation (AF) lasting \> one month
* history of at least one AF relapse after previous electrical or Pharmacological cardioversion

Exclusion Criteria:

* left atrium size \> 6 cm
* severe valvulopathy
* myocardial infarction during the previous 6 months
* unstable angina
* NYHA heart failure class IV or hemodynamic instability
* cardiac surgery during the previous 3 months
* significant pulmonary thyroid and hepatic disease
* contraindications to treatment with amiodarone or RASS inhibitors
* chronic renal dysfunction
* QT \> 480 msec in the absence of bundle-branch block
* bradycardia \< 50 b/min
* diagnosis of paroxysmal AF
* hyperkalemia
* pregnancy
* any disease or other medical treatment that, in the opinion of the investigators, could interfere with the study.
Graded Activity Versus Supervised Exercises in Patients With Chronic Non-specific Low Back Pain

The purpose of this study is to compare the efficacy of graded activity program and supervised exercise on pain, functional disability, quality of life, global perceived effect, return to work, physical activity, physical capacity and strength of the lower limbs in patients with chronic non-specific low back pain

Objective: To contrast the efficacy of of graded activity program and supervised exercise on pain, functional disability, quality of life, global perceived effect, return to work, physical activity, physical capacity and strength of the lower limbs in patients with chronic non-specific low back pain

Design: Sixty-six will be randomized into two groups namely: Graded Activity program (GA)(n = 33) and supervised exercise (SE) (n = 33). The primary clinical outcomes will be pain, assessed with the numerical pain scale and McGill Pain Questionnaire, and disability assessed with Roland Morris Disability Questionnaire. Secondary outcomes will be measured with Global Perceived Effect, quality of life, return to work, physical activity, functional capacity and strength of the lower limbs. The program lasts for 6 weeks, and sessions happen twice a week, with duration of one hour each. Evaluations will be performed before(baseline), after (6weeks) and with a follow-up 3 and 6 months after treatment. Data will be collected by a blinded examiner who also had made the allocation of patients to groups. Significance level is established at 5%.

Eligibility Criteria:
Inclusion Criteria:

* Patients with non-specific chronic low back pain for at least three months, age between 18 and 65 year of both genders and with a minimum pain intensity score of three in the 11-point Pain Numerical Rating Scale (ranging from 0 to 10 points).

Exclusion Criteria:

* Known or suspected serious spinal pathology (fractures, tumors, inflammatory or infective diseases of the spine);

  * Nerve root compromise;
  * Comorbid health conditions that would prevent active participation in the exercise programs;
  * Pregnancy;
  * Cardio Respiratory illnesses;
MCI Speech in Noise

The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes sound. The investigators are also evaluating, within those with MCI, whether the hearing tests are associated with neurocognitive functioning. The investigators are interested in learning whether changes in cognition in those with MCI can be detected using tests of how the brain processes sound. The investigators hypothesize that participants with MCI will score worse on both hearing tests and neurocognitive tests than participants without MCI. Participants are asked to complete multiple types of hearing tests, take a series of neurocognitive tests, and complete a few questionnaires.


Eligibility Criteria:
Inclusion Criteria:

* Adults diagnosed with or suspected to have MCI (for MCI group) or are cognitively normal (for Control group)
* Absence of other risk factors that might affect CAP (Central Auditory Processing) performance (e.g., active ear infections, congenital developmental delay, severe hearing loss)
* Age 55-80
* Normal hearing sensitivity (\<40 dB HL Pure Tone Average (average of 500, 1000, 2000 Hz) thresholds bilaterally
* Normal middle ear function defined by tympanometry (0.3-2.0 ml)
* Native English speaker

Exclusion Criteria:

* Active ear infections or abnormal middle ear pathology
* Other health condition prohibiting the completion of the CAP test battery
* Mild to profound peripheral hearing loss (\>40 dB (decibel) HL (hearing loss) Pure Tone Average (average of 500, 1000, 2000 Hz) bilaterally
* Adults unable to consent
* Individuals who are not yet adults (infants, children, teenagers)
* Prisoners
* History of CNS (Central Nervous System) disorder that might severely impact cognitive function (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, neurosyphilis, intracranial tumors, history of significant head trauma with loss of consciousness (≥30 min), and cerebrovascular disease)
* Severe mental illness (e.g., schizophrenia, bipolar disorder)
* Current, uncontrolled medical condition that could affect cognition (e.g., hypertension)
* History of substance use disorder within the (other than nicotine/caffeine)
* Non-correctable severe hearing or vision loss
* Use of "Cognition Enhancing Drugs"
* Frequent, severe headaches (occasional headaches or migraines are fine)
Stability of the Microbiome in IBD and IBS

In this study the investigators aim to investigate the changes of the intestinal microbiome in three different cohorts (IBD, IBS, healthy) after applying the uniform disruptive factor of osmotic diarrhea induced by macrogol. The investigators hypothesis is that ill people will show more severe changes of the microbiome than healthy people and that these changes persist longer.

I

Eligibility Criteria:
Inclusion Criteria:

* patients with inflammatory bowel disease and irritable bowel syndrome and stable therapy since three months
* patients with the indication for colonoscopy

Exclusion Criteria:

* age under 18
* pregnancy
* new therapy planned
* change of therapy within the last three months
* acute exacerbation of the inflammatory bowel disease
* colon pathologies of other origin: colocarcinoma, Illnesses with diarrhea (f.e.microscopic colitis), short bowel syndrome, malabsorption, colectomy
* intake of antibiotics in the last three months
* intake of probiotics in the last month
* intake of antibiotics or probiotics during the study
* new proton pump inhibitor therapy
* significant change of nutrition in the last three months
* holidays outside europe in the last month
* gastroenteritis in the last three months
* intake of laxatives
* nonsteroidal antiinflammatory drugs should be avoided and documented
Results of "Four Not Techniques" in Delayed and Nonunion Fractures of Lateral Humeral Condyle in Children

Fracture of lateral humeral condyle in children is not uncommon.The nonunion means no healing of the fracture after 3 months from the injury.Delayed union means no healing from 6 weels to less than 3 months after injury.

The treatment is difficult even surgery because of lack of blood supply of lateral condyle,unstability from muscle force and the articular fluid inhibition of union.

The author try to improve the healing of the fracture after surgery by "4 not techniques",

1. the surgical approach should not enter posteriorly because the blood supply of lateral condyle enter posteriorly in order to avoid cut the vessels.
2. The dissection should not too much especially the muscle around the condyle.
3. It is not necessary to perfectly reduced the fracture after nonunion to avoid too much dissection the muscle and allow only healing of the fragment.
4. Bone graft is not necessary. The author wants to know the results after perform "4 not technique" in delayed union and nonunion of lateral humeral condyle fracture

All children with delayed union or nonunion fracture lateral humeral condyle fractures will be inclued in the study.

The children who received the previous surgery of the same elbow will be excluded.

After full explanation and discussion to the children and parents.The surgery in "4 not technique" will be performed.

1. the lateral approach of the affected elbow and enter the fracture anteriorly. The approach should not enter posteriorly because the blood supply of lateral condyle enter posteriorly in order to avoid cut the vessels.
2. The dissection should not too much especially the muscle around the condyle. The nonunon fragment will be cleaned,washed and made until the healthy bone surface of fracture appear in both side of fracture.
3. It is not necessary to perfectly reduced the fracture after nonunion to avoid too much dissection the muscle and allow only healing of the fragment.The fixation by K-wires or screw in older children until the fragment is stable enough.
4. Bone graft is not necessary but in valgus deformity the correctuve osteotomy should be performed to correct the valgus.

The skin is closed,the long arm cast is put and change in 2 weeks interval until bone union.

The measurement will be

1. The union rate
2. The carrying angle , Baumann angle,shaft condylar angle
3. ROM
4. Complication of surgery such as infection,AVN of troclear etc.

Eligibility Criteria:
Inclusion Criteria:

* all children less than 18 years old with delayed union and nonunion of fracture lateral humeral condyle

Exclusion Criteria:

* any previous surgery at the same elbow
* refuse to participate the research
Ambu Aura-i Laryngeal Mask Versus Air-Q Intubating Laryngeal Airway for Tracheal Intubation in Adults

Supraglottic airway devices (SGA) become a routine part of the daily anesthesia practice. they can be used as primary airway devices or as conduits for endoracheal intubation and they become an integral part in the recent guidelines for managing difficult airway.

Air-Q ILA has been used successfully as 1ry airway and also as a conduits for endotracheal intubation.

The Ambu® Aura-i TM laryngeal mask is a new disposable SGA claimed to have special advantage over the competitors but not will studied as a conduit for endoracheal intubation.

This study is designed to compare the performance of Ambu®Aura-i™ laryngeal mask with the air-Q ILA as conduits for fiberoptic-guided tracheal intubation in adult population.


Eligibility Criteria:
Inclusion Criteria:

* patients aged from 18-60 years old, ASA I and II and scheduled for elective surgery under general anesthesia

Exclusion Criteria:

* history of cardiopulmonary disease, gastro-esophageal reflux disease, abnormal airway anatomy, body mass index \> 30 kg.m-2, surgical procedures including head and neck or performed in position other than supine or lithotomy
A Clinical Study to Assess the Efficacy and Safety of Dexamethasone Suspension for Cataract Surgery

Patients at least 40 years of age who are undergoing cataract surgery will be randomized to receive treatment with one of two dose levels of dexamethasone ophthalmic suspension eye drops to determine if the drops decrease inflammation inside the eye and are safe after cataract surgery.


Eligibility Criteria:
Inclusion Criteria:

* Male or female patients at least 40 years of age scheduled for unilateral cataract surgery by phacoemulsification with posterior chamber intraocular lens implantation.

Exclusion Criteria:

* Patients who have received a periocular corticosteroid injection in the study eye in the 3 months prior to screening.
* Patients who anticipate requiring treatment with any corticosteroids by any route, except inhalation, during the study.
* Patients who are known steroid responders