cyrilzakka/clinical-trials huggingface dataset:
MRI Guided Prostate Cancer Focal Laser Ablation

The study is a prospective, single-arm, non-randomized, unblinded trial to determine the safety and efficacy of MRI guided focal laser ablation of localized low and intermediate risk prostate cancer. All subjects meeting the inclusion exclusion criteria and are enrolled will undergo a MRI guided focal laser ablation procedure. The primary aim of the study is to study the safety and efficacy of the procedure.

Prostate cancer should be viewed as a spectrum of diseases ranging from a very indolent low-risk process to an aggressive high-risk potentially fatal disease. Active surveillance has been introduced as an alternative treatment to patients with low- risk prostate cancers.Focal therapy techniques have been introduced in prostate cancer to destroy the tumor itself with adequate safety margin with the advantage of preserving the surrounding non-cancerous tissue. Thus maintaining disease control at acceptable levels, while minimizing complications.

With the advent of multiparametric MRI (Mp-MRI), it is now possible to identify suspicious prostate gland focal lesions, determining their extent and targeting them for biopsy and focal ablation. Laser interstitial thermal therapy (LITT) is well suited for MRI environment. Laser fibers are flexible so they can fit into the MRI gantry. Laser has been shown to produce homogenous tissue necrosis that can be monitored by real time temperature maps, a feature that facilitates effective and safe ablation.

20 subjects with localized low and intermediate risk prostate cancer that meet the inclusion and exclusion criteria will be enrolled. During baseline evaluation, subjects will undergo lab tests, MR imaging, and will complete QOL questionnaires. Subsequently, subjects will undergo the Magnetic Resonance Imaging (MRI) Guided Focal Laser Interstitial Thermal Ablation procedure. Subjects will be followed immediately after the procedure, at 3 weeks, 3 months, 6 months, one year and two years after procedure for adverse events and recurrence of prostate cancer

Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years
* Patients with primary organ confined prostate cancer (≤T2c) and Gleason score ≤4+3=7

  * Lesions visible on multiparametric MRI and subsequently diagnosed by targeted MRI guided biopsy

Exclusion Criteria:

* Multifocal intra-prostatic disease, defined as the presence the presence of ≥ 3 non- contiguous pathologically proven foci of cancer.
* Gleason score \>4+3=7.
* Extracapsular spread.
* Nodal or distant metastasis
* Contraindications to MRI or general anesthesia.
* Uncorrectable Coagulopathy.
* Refusal of participation.
* Lesions not visualized on the multiparametric MRI
Vaccination Status, Knowledge and Attitude in Korean Patients With IBD

The purpose of this study is to investigate the vaccination status, knowledge about vaccination, and attitude to vaccination of the Korean patients with inflammatory bowel diseases

Using structured questionnaires, the vaccination status, knowledge about vaccination, and attitude to vaccination of the Korean patients with inflammatory bowel diseases will be investigated. The descriptive analyses will be performed and the factors influencing the vaccination status, knowledge, and attitude will be investigated.

Eligibility Criteria:
Inclusion Criteria:

* Crohn's disease or ulcerative colitis
* Patients who are visiting Asan Medical Center for the first time for the management of inflammatory bowel diseases
* Patients who give consent for participating in the study

Exclusion Criteria:

* Patients who refuse to participate in the study