cyrilzakka/clinical-trials huggingface dataset:
Evaluation of the Improvement of Independence by the Resumption of a Significant Activity Such as a Cooking Workshop in Adult Patients With Stroke Benefiting From Traditional Rehabilitation

A non-randomized, monocentric, pilot study comparing the level of independence for each individual with significant resumption of activity in adult patients with stroke


Eligibility Criteria:
Inclusion Criteria:

* Patient older than 18 years old
* Primary stroke or recurrence on stroke having no previous sequelae
* Stroke older than 3 weeks
* Ability to understand treatment and sufficient motivation
* Problem Activity Indicated in CMOP (Canadian Measure of Occupational Performance)
* Barthel Index \> 60
* Patient who received oral and written information about the protocol and who did not show opposition to participate in the study

Exclusion Criteria:

* Dermatological pathology with wounds on the unhealed upper limbs
* Patient in contact and droplet isolation
* A psychiatric history requiring hospitalization in specialized settings for more than 2 months
* Any condition that may limit participation or interfere with analysis of results
Adujvant CT+CRT vs Adujvant CT After D2 Resection for Locally Advanced Proximal Gastric Adenocarcinoma

This study evaluates the addition of adjuvant chemoradiotherapy to adjuvant chemotherapy in the treatment of locally advanced proximal gastric adenocarcinoma after standard D2 radical resection.

Because of its special anatomical structure, local recurrence rate of locally advanced proximal gastric adenocarcinoma is still high after radical operation.

As a local/regional therapy, radiotherapy combined with concurrent chemotherapy can kill local residual tumor cells and reduce the risk of local and regional recurrence.

Eligibility Criteria:
Inclusion Criteria:

* Voluntary Participation and Written Signature of Informed Consent.
* Age 18-70, gender unlimited.
* Gross pathology confirmed that the tumor center was within 1 cm to 5 cm of the EGJ line. Histopathologically diagnosed as adenocarcinoma.
* No neoadjuvant therapy.
* Transabdominal standard D2 radical operation was performed and R0 resection was performed. Ascites cytology was negative.
* The pathological stages were IIB, IIIA, IIIB and IIIC.
* There was no intraperitoneal implantation and distant metastasis. CT should be routinely performed to evaluate the tumor bed before radiotherapy. Positron emission tomography (PET-CT) could be accepted to determine whether there was residual or distant metastasis.
* Physical condition score ECOG 0-1.
* No history of serious heart and lung diseases, abnormal hematological examination and immunodeficiency: hemoglobin (Hb) \> 9 g/dL; white blood cell (WBC) \> 3 x 109/L; neutrophil (ANC) \> 1.5 x 109/L; platelet (Pt) \> 100 x 109/L; bilirubin \< 1.5 times the upper limit of normal value; glutathione transaminase (ALT) \& alanine transaminase (AST) = 2.5 times the upper limit of normal value; serum creatinine \< 1.5 times the normal value Upper limit.
* No other systemic tumors were found.
* Fertile men or women are willing to take contraceptive measures in the trial.
* The daily energy intake is more than 1500 kcal.

Exclusion Criteria:

* Those who had a history of malignant tumors (except skin basal cell carcinoma, thyroid papillary adenocarcinoma and cervical carcinoma in situ, who survived for more than 3 years after treatment).
* Patients with a history of neoadjuvant radiotherapy and chemotherapy before operation.
* Study participants who participated in other clinical trials within 30 days before treatment.
* Pregnancy, lactation or fertility without contraceptive measures.
* Drug addiction and other adverse drug addiction, long-term alcoholism and AIDS patients.
* Those with uncontrollable infections, seizures, or loss of self-awareness due to mental illness.
* Those with a history of severe allergy or specific constitution.
* Researchers believe that it is not appropriate to participate in this experiment.
Non-interventional (NI) Study to Observe Efficacy and Usage of Quetiapine in Acute Episodes of Schizophrenia and as Maintenance Therapy Following Standard Clinical Practice in Croatia

Observational, non-comparative, epidemiological study to collect and analyse real life data on schizophrenic patients receiving quetiapine according to the standard medical practice in Croatia. The main objectives are to assess after 6 months of quetiapine therapy severity of illness and global improvement in patients using Clinical Global Impression (CGI) scale.


Eligibility Criteria:
Inclusion Criteria:

* Patients with diagnosis of schizophrenia
* Patients who are already treated with quetiapine for at least 12 weeks (outpatients or hospitalised patients)
* Patients capable of signing ICF

Exclusion Criteria:

* Patients with hypersensitivity to active substance or any of the excipients of this product
* Patients with contraindication for quetiapine therapy according to the approved SmPC
Effect of Pitavastatin on Bone

This clinical trial investigates the effects of pitavastatin on bone health in postmenopausal women with osteopenia or osteoporosis and hypercholesterolemia. Given the high prevalence of osteoporosis in aging populations and the associated risks, even with existing treatments, this study addresses a critical gap in medical research. Statins, specifically HMG-CoA reductase inhibitors, are suggested to benefit bone metabolism by promoting bone formation and reducing resorption. However, the specific impact of pitavastatin on bone metabolism lacks clinical evidence.

The study's primary goal is to determine the effects of a 12-month pitavastatin regimen on bone metabolism markers in this population. This research could significantly contribute to developing more effective osteoporosis treatments for postmenopausal women, combining bone health and cholesterol management strategies.


Eligibility Criteria:
Inclusion Criteria:

* Patients who are under the age of 75 and are postmenopausal.
* Individuals diagnosed with osteopenia or osteoporosis, exhibiting a T-score ranging from -3.0 to -1.5.
* Patients with hypercholesterolemia starting pitavastatin for the first time.
* Patients exhibiting baseline bone resorption markers, specifically C-telopeptide levels of 0.300 ng/mL or above, or NTX levels above 16.5 nmolBCE/L.

Exclusion Criteria:

* Patients who have used a statin medication for more than one month within the last 3 months.
* Patients who have used oral or injectable glucocorticoids for more than one week within the last 3 months.
* Patients currently using thiazolidinediones, a class of oral antidiabetic medications.
* Patients undergoing treatment for malignant tumors.
Post-approval Study of The Glaukos® iStent® Trabecular Micro-bypass Stent: Extended Follow-up of the Premarket Cohort

The purpose of this study is to assess the long-term safety of the Glaukos® iStent® Trabecular Micro-Bypass Stent Model GTS100R/L in subjects previously enrolled in Glaukos Study GC-003.

The goal of this study was to demonstrate that use of this device in conjunction with cataract surgery did not result in a rate of sight-threatening adverse events, after 5 years of implantation that was higher than the rate of sight-threatening adverse events that occurred after cataract surgery alone, by more than a non-inferiority margin of 5%.

Eligibility Criteria:
Inclusion Criteria:

* Subjects previously enrolled in Glaukos Study GC-003 who are able and willing to participate in this extended follow-up study

Exclusion Criteria:

* Subjects previously enrolled in Glaukos Study GC-003 who are not able or willing to participate in this extended follow-up study
* Patients not previously enrolled in Glaukos Study GC-003
Multi-site Trial Using SMS to Improve Infant Weight

The goals of this multi-site clinical trial are to pilot test weekly SMS sent to parents/caregivers of infants to improve feeding practices and decrease excessive weight gain in infants who are participants of the Women, Infants and Children (WIC) program in Puerto Rico and Hawaii. The intervention consists of weekly SMS for 4 months to reinforce the feeding messages provided by WIC.

The goals of this multi-site clinical trial are to pilot test weekly SMS sent to parents/caregivers of infants to improve feeding practices and decrease excessive weight gain in infants who are participants of the WIC program in two distinct locations, Puerto Rico and Hawaii; to assess acceptability and practicality of the intervention; and to assess acceptability of collecting blood spots in future studies. The investigators will recruit a convenience sample of parent/caregivers of infants 0-2 months participating in the WIC program in Puerto Rico and Hawaii to send weekly SMS for 4 months. The weekly messages will focus on reinforcing the breastfeeding messages provided by WIC, preventing overfeeding, delaying introduction of solid foods, and delaying and reducing baby juice consumption, which are key issues in low-income populations. Participants will complete validated questionnaires and anthropometry before and after the trial and results will be compared to the control group (no messages). Participants will also answer short questions by SMS at different points and an interview at the end of the trial to assess the SMS. The investigators will assess how many participants agree to collect blood spots in their infants in future studies.

Eligibility Criteria:
Inclusion Criteria:

* Caregiver age 18 years and older
* owner of a mobile phone with unrestricted SMS capability
* responsible for the care of the infant and willing to actively participate for the full duration of the study.

Exclusion Criteria:

* infants with special diets
* infants with limited mobility
* pre-term birth (\<37 weeks)
* small or large for gestational age (birthweight \<10th or \>90th p)
* inability to consent to participate in the study
* unwillingness to be randomized and not being able to read
Efficacy of Different Behaviour Change Techniques in MyPlan 2.0

The aim of this study is to investigate the effectiveness of intervention 'MyPlan 2.0' and the efficacy of the different behaviour change techniques that are included. Eight groups will be created that will receive a different version of the intervention, varying in three behaviour change techniques (action planning, coping planning, self-monitoring).

The effectiveness of the self-regulation-based e- and m-health intervention 'MyPlan 2.0' on changing physical activity and sedentary behaviour in the adult population will be investigated. Furthermore, the role of three different behaviour change techniques (action planning, coping planning, self-monitoring) will be examined via a 2x2x2 design, in which 8 groups are created that all receive a different version of the intervention.

Eligibility Criteria:
Inclusion Criteria:

- 18 years old or older

Exclusion Criteria:

* Not Dutch-speaking
* Does not own a smartphone
* Does not have access to the internet
* Is not able to be physically active/non-sedentary
Impact of Maxillomandibular Deformities on Individuals' Nutritional Status

This cross-sectional study explores the influence of various types of maxillomandibular deformities on the nutritional status of individuals. Maxillomandibular deformities, which involve the misalignment of the upper and lower jaws, can significantly affect oral functionality, potentially leading to nutritional deficiencies due to compromised food intake. By analyzing the dietary habits and nutritional health of a diverse group of individuals with these deformities, the study seeks to establish the correlation between the severity of the deformity and the individual's nutritional status. Findings from this research can provide a deeper understanding of the additional health risks that maxillomandibular deformities pose and help in the development of nutritional guidelines specifically tailored for individuals suffering from these conditions.


Eligibility Criteria:
Inclusion Criteria:

* Adults aged between 18 and 45 years old
* Individuals who are not currently undergoing orthodontic treatment and have a complete set of teeth, excluding wisdom teeth.
* Citizens of the Republic of Turkey
* Able to read and write in Turkish language
* Able to understand and follow the questionnaire instructions
* Willing to participate in the study

Exclusion Criteria:

* Individuals above 45 years old
* Unwilling to sign the informed consent for participation in the study
* Unwilling to answer all the questionnaire items
* Individuals with a chronic disease that requires a specific diet
* Individuals with any eating disorders
* Pregnant and/or nursing individuals
* Individuals with cognitive impairment to a degree that would prevent giving clear and accurate responses will be excluded from the study.
Video, Telephone or Face-to-face Surgical Consultations: a Survey of Patients' and Surgeons' Views

This study will send out questionnaires to surgical outpatients and surgeons to gather their views on the appropriate type of surgical outpatient consultation in different clinical scenarios, in order to establish a guideline for surgical outpatient planning.

As above - this study will send out questionnaires to surgical outpatients and surgeons to gather their views on the appropriate type of surgical outpatient consultation in different clinical scenarios, in order to establish a guideline for surgical outpatient planning.

Eligibility Criteria:
Inclusion Criteria:

PATIENTS

Adults attending general surgical outpatients in Aberdeen Royal Infirmary during the study period presenting with:

* lumps and bumps
* hernias
* biliary problems
* jaundice
* abdominal pain/mass/weight loss
* gastro-oesophageal reflux
* dysphagia
* change in bowel habit
* anorectal problems
* thyroid nodules
* parathyroid disease
* adrenal masses

SURGEONS

Consultant General Surgeons in NHS Grampian / Tayside and Highlands

Exclusion Criteria:

PATIENTS

* lacking capacity
* without language skills to answer questionnaires or ability to understand questionnaires
* children \< 16yrs (No upper age limit)
* patients presenting as emergencies
* patients unwilling to complete questionnaires.

SURGEONS

- trainee surgeons.
Study Evaluating of Calcineurin Inhibitors Versus Sirolimus in Renal Allograft Recipient

This study will evaluate whether conversion from cyclosporine, a calcineurin inhibitor (CI) to sirolimus (SRL) results in improved long-term renal function without a negative impact on safety or immunosuppressive efficacy, and to further examine the potential of SRL to reduce the severity and/or progression of chronic allograft nephropathy (CAN).

This open-label, randomized, parallel-group, comparative, outpatient study will be conducted in multiple centers in Taiwan.

The study will randomize approximately 120 patients. 80 patients will be randomized to the SRL therapy group (conversion from CI- to SRL-based immunosuppression: group A) and 40 patients to the CI therapy group (continued CI therapy: group B).

Dosage and Administration

SRL Therapy: At the time of randomization on day 1, each patient will have been receiving:

* triple therapy with a CI (tacrolimus or CsA) that began at the time of transplantation or within 2 weeks thereafter AND
* corticosteroids corresponding to a dosage range of 2.5 to 15 mg/day for prednisone or prednisolone (2 to 12 mg/day for methylprednisolone) or the alternate day equivalent for at least 12 weeks before randomization, PLUS
* either MMF (minimum dose 500 mg/day)/MPS (minimum dose 360 mg/day) or AZA (minimum dose 50 mg/day) for at least 12 weeks before randomization.

SRL will be added to the immunosuppressive regimen for Group A. Group B will continue on this CI immunosuppressive regimen.

Eligibility Criteria:
Inclusion Criteria:

* Subjects must be at least 18 years of age.
* Subjects who are 6 to 60 months after renal transplantation.
* Subjects who have a stable graft function.

Exclusion Criteria:

* Subjects with active major infection, including HIV, decreased platelets, elevated lipids, or multiple organ transplants.
Impact of Pharmaceutical Care on Drug-related Problems in Patients With Parkinson's Disease

The aim of this study is to evaluate the impact of pharmaceutical care on the number of drug-related problems, clinical outcomes and quality of life of patients with Parkinson's disease.

This is a randomized controlled study that will be conducted in Parkinson's disease and movement disorders clinic, Siriraj Hospital, Thailand. The participants and assessors evaluating MDS-UPDRS were blinded in this study.

The participants will be divided into two groups by block randomization: intervention group and usual care group.

For the intervention group, the clinical pharmacists will conduct medication reviews, patient education, and counseling. Moreover, the clinical pharmacists will identify drug-related problems (DRPs) and provide the information through written pharmacist notes to physicians at the clinic. For patients randomized to the control group will attend the medical follow-up as usual and receive usual care. Telepharmacy will be conducted 2-7 days before the doctor visit and within 1 week after the doctor visit. Data collection will be conducted at baseline, week 12, and week 24 in both groups. After the follow-up, the pharmacist will count the number of drug-related problems identified after the doctor visit. The primary outcome of the study is comparing the number of drug-related problems per person changed from the start of the study to the end of week 24 between two groups.

Eligibility Criteria:
Inclusion Criteria:

1. Age 18 years or older
2. Diagnosed with idiopathic Parkinson's disease according to the UK Parkinson's disease Society Brain Bank Criteria for at least 3 years
3. Modified Hoehn and Yahr stage 2-4
4. Patient had received at least one of antiparkinsonian drugs the following: levodopa, MAO-B inhibitors, dopamine agonists, COMT inhibitors, amantadine, and trihexyphenidyl
5. Patient has given a written informed consent to participate in the study. If the patients are unable to give an informed consent, it must be obtained from the caregiver.

Exclusion Criteria:

1. Patient is unable to communicate via telephone or mobile phone or internet.
2. Patient who is terminal illness
3. Patient who is bed ridden
4. Patient with other movement disorders include corticobasal syndrome, multiple system atrophy, progressive supranuclear palsy and essential tremor
5. Moderate to severe dementia as evidenced by Mini Mental State Examination (MMSE) or Thai Mental State Examination (TMSE) less than 20 and without the caregiver
6. Patient who is planning to undergo surgery or have a history of surgical treatment for Parkinson's disease such as pallidotomy, thalamotomy, or deep brain stimulation
7. Patient with hearing impairments which affects communication via telephone or electronic media
8. Unable to communicate Thai language
Weight Stigma in Women Who Are Obese: Assessing How an Acute Exposure to Stigma Negatively Impacts Cardiovascular Health

The current study examined the influence of an acute weight stigma exposure on cardiovascular reactivity among women with obesity and high blood pressure and women with obesity and normal blood pressure.

The current study examined the influence of two video exposures, one containing scenes of weight stigma (STIGMA) and the other non-stigmatizing neutral (NEUTRAL) scenes, on cardiovascular reactivity as assessed by resting BP and ambulatory blood pressure (ABP) and heart rate (HR), among women with obesity and high BP (HBP) or normal BP (NBP). The investigators hypothesized that as a result of STIGMA compared to NEUTRAL, cardiovascular reactivity would be significantly greater immediately upon watching the video and persist outside of the laboratory over ambulatory conditions in women with obesity and HBP compared to women with obesity and NBP.

Eligibility Criteria:
Inclusion Criteria:

* Premenopausal
* BMI \> 30 kg/m2
* No other known chronic cardiovascular or metabolic diseases besides hypertension

Exclusion Criteria:

* Pregnant or planned on becoming pregnant
* Took medications that may have affected the primary outcome of BP (e.g., stimulants for attention deficit hyperactivity disorder or steroids for asthma)
* Currently using tobacco products
* Diagnosed with an eating disorder
Prevalence of Influenza RelAted Invasive Aspergillosis

This is a multicenter study with the aim to determine the prevalence of influenza-related invasive pulmonary aspergillosis in Swedish intensive care units and to assess the clinical impact of and risk factors for influenza-related invasive pulmonary aspergillosis

This is a multicenter prospective observational study conducted at 12 intensive care units (ICU) in Sweden. All patients \>18 years of age with a Polymerase Chain Reaction (PCR)-verified influenza A or B diagnosed up to 7 days before admission to the ICU or during ICU care, will be included in the study.

A new clinical routine has been implemented at the study centers: During the ICU stay screening with Beta-D-glucan and Galactomannan in blood/serum will be performed twice weekly and a respiratory sample will be retrieved for fungal culture and microscopy once weekly.

All results from collected samples will be available to the patient's attending physicians. Clinical and microbiological data will be collected, and the diagnosis of invasive aspergillosis will be made using predefined diagnostic criteria.

Objectives:

1. To determine the prevalence of influenza-related invasive pulmonary aspergillosis in Swedish intensive care units
2. To assess the clinical impact of and risk factors for influenza-related invasive pulmonary aspergillosis

Eligibility Criteria:
Inclusion Criteria:

* Confirmed influenza A or B diagnosed up to 7 days before ICU admission, or during ICU care
* Admitted to the ICU

Exclusion Criteria:

- Under 18 years of age
Effect of Mat Pilates Training on Blood Pressure of Hypertensive Individuals

The study aimed to evaluate the chronic effects of Mat Pilates Training on blood pressure, heart rate, double product and psychobiological factors in hypertensive medicated women and acute effects of Mat Pilates Exercise on blood pressure of such individuals.


Eligibility Criteria:
Inclusion Criteria:

* Hypertensives women
* Age 30 to 59 years
* Nonactive
* Make use of antihypertensive medication

Exclusion Criteria:

* Orthopedic problems or other problem that prevented the exercises
* Change in drug treatment during protocol
* Absence in more than 25% of the exercise sessions