cyrilzakka/clinical-trials huggingface dataset:
(1,3)-Béta-D-Glucan Levels at Diagnosis of Juvenile Idiopathic Arthritis and Its Correlation With Activity's Disease : a Cohort Sudy

Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease of childhood. Most children still experience prolonged periods of active disease, however, there is still lack of effective and specific markers for early diagnosis of relapse. The pathogenesis of JIA is thought to be the result of a combination of host genetic and environmental triggers and The microbiota is a potential contributing factor to the development of the disease. (1-3)-ß-D-Glucan (BDG), a component of most fungal cell walls, possess immunomodulatory activities. Latest studies demonstrate that it acts as a trigger for autoimmune arthritis in adult. However the relation with JIA is not clearly defined. The objective of this study was to evaluate the (1,3)-Béta-D-Glucans level in patients with JIA and whether higher serum BDG levels are correlated with JIA activity of disease, comparatively with usual markers.


Eligibility Criteria:
Inclusion Criteria:

* All patients under the age of 18 years with JIA's disease
* followed at the CHU Amiens (French University hospital)
* signed parent consent form

Exclusion Criteria:

* lack of consent from parents or patient
Evaluation of of a Prefixed 50% N2O- 50%O2 Mixture in Legal Abortion Under Local Analgesia

To evaluate effectiveness of a prefixed 50% N2O- 50%O2 mixture in legal abortion under paracervical block.


Eligibility Criteria:
Inclusion Criteria:

* Major patient having signed an assent waits having chosen to make the intervention under local anesthetic

Exclusion Criteria:

* Minor
* contraindication in the use of the paracetamol, the lidocaine
* Porphyries
Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian Institute

This is a retrospective cohort study that aims to evaluate the correlation of magnetic resonance tumour regression grade (mrTRG) and pathological TRG (pTRG) of locally advanced rectal cancer after neoadjuvant long course chemoradiotherapy as well as the prognostic value of mrTRG on survival.


Eligibility Criteria:
Inclusion Criteria:

* Rectal cancer
* At least 1 high risk feature on MRI
* Undergo long course neoadjuvant chemoradiotherapy (LCCRT)

Exclusion Criteria:

* metastatic disease
* Patients who undergo short course radiotherapy
* Patients without a repeat MRI after completion of LCCRT
Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells

The goal of this study is to investigate the overall theory that the use of chemically preserved solutions associated with contact lenses promotes an increase in bacterial infection.

The purpose of this study is to investigate the theory of bacterial binding to surface eye cells through the use of chemically preserved solutions.

Eligibility Criteria:
Inclusion Criteria:

* Age range: 18-38 years
* Any sex, race or national origin accepted as with our past studies. Minority representation will be proactively encouraged.
* No prior history of any contact lens wear within one month of entry into the study.
* No history of allergic eye disease either seasonal or associated with previous contact lens wear.

Exclusion Criteria:

* Any patient that is a current contact lens wearer.
* Patients with active ocular infection or inflammatory disease, history of herpetic keratitis, glaucoma, etc.
* Uncontrolled systemic disease or the presence of any significant illness or condition that could, in the judgment of the investigator, interfere with interpretation of the study results.
* Any patient using ocular tears, anti-histamine based ocular therapies, glaucoma therapy, vasoconstricting drops, etc.
Randomized Multicenter Trial of Prehospital Initiated Facilitated Percutaneous Coronary Intervention (PCI) Versus Primary PCI in ST-segment-Elevation MI (STEMI)

Prehospital initiated facilitation of primary percutaneous coronary intervention by fibrinolysis might be helpful in re-opening the infarct related artery prior to percutaneous coronary intervention.

This studies tests the hypothesis that prehospital initiated facilitated PCI is superior to primary percutaneous coronary intervention with respect to infarct size.

Patients with STEMI with symptoms \< 3 hours are randomized in the region of Leipzig to either prehospital full-dose fibrinolysis (+ASA, Clopidogrel and heparin) with subsequent facilitated percutaneous coronary intervention or to primary percutaneous coronary intervention (after ASA + heparin + clopidogrel).

Patients undergo cardiac magnetic resonance for assessment of infarct size early at day 1-4 after randomization.

Eligibility Criteria:
Inclusion Criteria:

* Angina pectoris \< 3 hours
* ST-elevation myocardial infarction

Exclusion Criteria:

* Active bleeding
* Active gastric ulcus
* Previous stroke
* Uncontrolled hypertension (\> 200 mmHg)
* Cerebral surgery \< 8 weeks
* Major surgery \< 4 weeks
* Malignancy
* Treatment with coumarines
* Pregnancy
Exercise Dose-Response on Features of the Metabolic Syndrome

This study investigates the degree of improvement in insulin resistance and features of the metabolic syndrome in non-diabetic overweight or obese subjects after training in a low-intensity, moderate-intensity or non-aerobic exercise program, as well as self-initiated exercise behavior after the assigned exercise program.

The proposed study is a randomized, open study comparing low-intensity and moderate-intensity aerobic exercise versus non-aerobic (stretching) exercise on direct measurements of insulin resistance and variables associated with the metabolic syndrome. This 6-month intervention will be followed by an additional 6-month follow-up period during which subjects will be encouraged to maintain their exercise regimen (along with their prescribed diet) but without scheduled supervision. Behavioral variables associated with adherence will be analyzed along with changes in the above physiological variables.

Eligibility Criteria:
Inclusion Criteria:

* Males or females, age 18-60
* At least 2 of the 5 components of the NCEP definition of the metabolic syndrome, provided that either the triglyceride or waist circumference criteria are met
* Body mass index of 25-45 kg/m2
* Subjects not currently following a regular exercise program nor an optimal diet, and who self-report their activity level as sedentary
* Able to understand and sign the informed consent form, follow the instructions given in the study, attend all necessary clinic visits, and undergo all required study procedures

Exclusion Criteria:

* Past or current diabetes mellitus
* Significant concurrent medical illnesses (chronic liver or renal disease, malignancies, recent or chronic infections including HIV, surgeries or other hospitalizations within four weeks prior to screening), uncontrolled hypertension (BP \>160/90 mm Hg), or abnormal TSH on screening.
* Conditions that may contraindicate physical activity (clinically significant cardiac, pulmonary, orthopedic, rheumatological or neurological diseases)
* Cardiovascular disease not controlled with medical therapy, or invasive vascular procedures within six months prior to screening
* Subjects found on resting EKG or stress testing to have underlying cardiac abnormalities
* Perimenopausal women who are experiencing irregular menses
* Pregnant or lactating women
* Subjects who may have limited exercise tolerance because of treatment with β-adrenergic blockade agents, at least until agents of alternate drug classes can be substituted
* Subjects with concurrent endocrinopathies
* Subjects receiving concurrent treatment with metformin, thiazolidinediones, systemic glucocorticoids, or any weight loss agents
* Subjects who expect to require medications during the course of the study that may affect their metabolic profile, including systemic glucocorticoids and hormone replacement therapies
* Subjects who cannot complete the stress test due to physical limitations
* Any other factors that, in the opinion of the investigators, may interfere with the safe conduct, the successful completion, or the quality of the data obtained from the study
Monitoring and Preventing Hydroxychloroquine, Plaquenil, Toxicity.

Oral Hydoxychloroquine is a very popular medication widely used by patients with rheumatoid arthritis, Systemic Lupus Erythematosus and other diseases. Ocular side effects of this medication are very serious and causes loss of central vision. In most patients these side effects are dose related, cumulative. This means that the risk of side effects would increase in all patients with continued use of the medication. In few people use of the medication would not be recommended if they have some bilateral macular problems. This is because the side effects of this medication does cause serious degredation of the macula in both eyes.

The ocular side effects of Hydroxychloroquine has been known for long time. Due to the seriousness of these side effects all possible efforts were done to prevent them. Preventing these side effects would ideally need prior screening of all patients who are to use oral Hydroxychloroquine. If patients are not screened prior to oral Hydroxychloroquine use they should be examined as soon as possible after starting this medication. Advances in technology, specifically the advent of optical coherence tomography, made screening and monitoring for Hydroxychloroquine toxicity much more easier and reliable meantime.

Eligibility Criteria:
Inclusion Criteria: all patients who need treatment with oral Hydroxychloroquine.

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Exclusion Criteria: patients who are not using oral Hydroxychloroquine.

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A Decision Support System for Self-management of Low Back Pain - PILOTSTUDY

The pilot study precedes a larger randomized controlled trial, to be starting in February 2019.

In this pilot study all participants are allocated to the intervention group.

The intervention consists of a digital decision support system delivering a weekly plan of suggested activities that the participant can use to self-manage their low back pain. The plan is presented to the participant in the selfBACK app.

The selfBACK intervention consists of the selfBACK system, that provides the participants with an individually tailored weekly plan of suggested activities to use in their self-management of low back pain.

The SELFBACK system constitutes a data-driven predictive decision support system that uses Case-Based Reasoning methodology to capture and reuse participant cases in order to suggest the most suitable self-management plan for participants. The selfBACK system is an intelligent system that will adjust the suggested self-management plan to the individual participants by using the information available on the participant (baseline questionnaires), weekly self-reported of changes in health status through the app, and data on physical activity via the step-detecting wristband.

The weekly plan includes three categories of content; 1) information/education, 2) physical activity monitoring through wearing a step-detecting wristband, and 3) strength and flexibility exercises.

Eligibility Criteria:
Inclusion Criteria:

* Seeking care from primary health-care practice or a specialised outpatient hospital facility (DK) for non-specific LBP within the past 8 weeks
* LBP of any duration
* Mild-to severe pain-related disability rated as 16 or below on the PROMIS-PF4 function scale.
* Age: ≥18 years
* Own and regularly use a smart phone (with at least Android 7.0 or iOS11.0) with internet access (Wi-Fi and/or mobile data)
* Have a working email address and have access to a computer with internet access to complete questionnaires in a web browser.

Exclusion Criteria:

* Not interested
* Unable to speak, read or write in the national language (Danish/ Norwegian)
* Cognitive impairment or learning disabilities
* Pathology, such as fracture, cancer, inflammatory diseases, and signs of radiculopathy (severe leg pain, loss of leg strength, or loss of or altered sensation in a myotomal or dermatomal distribution)
* Serious mental illness, such as major depression, schizophrenia, and psychosis
* Terminal illness
* Unable to take part in exercise/physical activity (such as non-ambulatory patients, use of walking aids/assistance, unable to get down and up from the floor independently)
* Fibromyalgia (diagnosed by a Health Care Professional)
* Pregnancy
* Previous back surgery
* Ongoing participation in other research trials for LBP management
Work in Green Spaces and Musculoskeletal Disorders

Musculoskeletal disorders (MSDs) of the limbs and spine are painful conditions of the periarticular soft tissues (muscles, tendons, vessels, etc.) and peripheral nerves secondary to overuse of occupational origin.

They can manifest as pain (the most common symptom), discomfort, stiffness, loss of precision in movements or loss of strength. The lumbar spine and upper limbs are the parts of the body most frequently affected by MSDs.

MSDs have a multifactorial origin that can be separated into 2 categories: factors linked to the individual (age, sex, medical history) and factors linked to the work environment (biomechanical constraints, work organization, psychosocial risks).

MSDs are the leading cause of compensated occupational illnesses in France (86% of occupational illnesses in 2021, according to the Health Insurance annual report), particularly in the agricultural sector to which the majority of professions in green spaces belong. . If, in the Grand Est of France, the prevalence of employees exposed to physical risks decreased in the majority of sectors of activity between 1994 and 2017, we note at the same time a slight increase in the prevalence in the agricultural sector over this period. same period (6% in 2017 compared to 3.7% in 1994, SUMER 2017 survey).

Concerning the current context in France, the green spaces sector has undergone changes in recent years following the national implementation of the Ecophyto plan in 2008 (updated in 2015 then in 2018). This plan, the latest version of which is called Ecophyto 2+, aims to reduce the use of plant protection products by 50% by 2025. At the same time, the use of plant protection products for the maintenance of green spaces, forests, roads and walks have been prohibited by the Labbé law since January 1, 2017. In this context, and given the absence of recent data from the literature on this subject in France, the investigator wishes to carry out an inventory recent physical and organizational constraints, as well as the prevalence of MSDs, in the green space sector (targeting more particularly in its study the green spaces of the Territorial Civil Service of the Grand Est)


Eligibility Criteria:
Inclusion Criteria:

* Major subject from 18 to 62 years old
* Subject working in the service of green spaces in the Territorial Civil Service in a city in the Grand Est, active when the study was carried out
* Subject agreeing to participate in the study
* Subject with sufficient command of the French language to understand the self-questionnaire

Exclusion Criteria:

* Subject not wishing to participate in the study
* Subject on sick leave
* Subject under 18 years old or over 62 years old
* Subject under guardianship or curatorship
* Subject under judicial protection
The Use of Remote Monitoring to Improve Patient-Reported Outcomes and Readmission Rates Following Radical Cystectomy

Following radical cystectomy for bladder cancer, nearly two-thirds of patients experience a complication and almost a third are readmitted. Thus, intensified monitoring of this vulnerable group represents an opportunity for improved quality of care in the post-operative setting. By gathering biomarkers passively and continuously, wearable activity monitors augment remote patient monitoring. Further, they facilitate the collection of patient-reported outcomes frequently.

Despite the proven impact of remote monitoring on patient care, there is limited data on the feasibility and impact of employing this technology to trigger real-time provider assessment following cystectomy. The investigators plan to conduct a randomized control trial examining such. The intervention group of participants will receive continuous biomarker monitoring via FitBits and daily patient-reported outcome assessments via connected smartphones. Abnormalities in remote data will trigger automated alerts to providers. Providers will respond in real-time to these alerts and patients will receive education materials discussing preventative measures to mitigate the main risk factors for readmissions. The investigators will evaluate the feasibility of integrating this technology into the post-operative period, as well as the impact of real-time provider attention to abnormal remote data on patient-reported outcomes and rates of readmission. The investigators hypothesize that early assessment of and intervention on remote abnormalities will promote the use of outpatient or reduced intensity therapies, such as oral antibiotics or oral hydration, thus curtailing the severity of patient symptoms, intensity of complications, and need for hospitalizations. Ultimately, this trial builds upon prior research, applying patient-centered technology to improve the quality of care following cystectomy.


Eligibility Criteria:
Inclusion Criteria:

* undergoing cystectomy at three hospitals within the University of Pittsburgh Medical Center system
* English speaking
* owns smart phone

Exclusion Criteria:

* unwilling or unable to participate
* non-English speaking
* does not own smart phone
Quality of Life, Anxiety and Fatigue Level of Parkison's Patients With Color Therapy

The aim of this study was to investigate the effect of color therapy on quality of life, anxiety and fatigue levels in patients with Parkinson's disease.

Color Therapy aims to balance and heal our body's energy centers using the seven color spectrum, which helps to promote our body's own healing process. Thus good health and well-being is achieved through the balance of all these energies. Color therapy basically consists of color and character analysis with name, color therapy with chakras, programming of the pendulum, chakras and color application, color application with water, color application with colored light device.

Eligibility Criteria:
Inclusion Criteria:

* Having been diagnosed with Parkinson's disease for at least 6 months,
* Those who have not taken sleeping pills or sedative drugs,
* Not having undergone brain stimulation surgery,
* Do not have a physical illness or cognitive disability that would prevent them from understanding the education provided, and do not have a diagnosis of a psychiatric disease,
* According to the Parkinson's Fatigue Scale, the scale score is \>8
* The patient or someone living in the same house with the patient is literate,
* Patients have no vision problems.

Exclusion Criteria:

* Parkinson patients who did not agree to participate in the research
The Effects of Viscoelastometry Guided Resuscitation During Burn Excision on Post Resuscitation Infections

This is a randomized controlled trial to compare viscoelastometric (VE) guided transfusion to standard practice transfusion in severe thermal injury burn excision on the utilization of blood products, effects on coagulation and inflammatory mediators, and how these strategies affect post resuscitation infections.

This is an open labeled study as the viscoelastometric (VE) guided transfusion will be based on the visible VE results. Subjects will be randomized to receive either the standard practice transfusion or VE guided transfusion. Blood samples, standard demographic information, and routine laboratory data will be collected on all subjects in the Burn ICU (BICU) enrolled in the study. VE analysis will be performed on ALL subjects immediately prior to the burn excision, and approximately every 40 minutes while the patient is in the operating room (OR) as well as on arrival to the BICU and every 8 hours depending on their need for ongoing transfusion for a maximum of 24 hours. As our intervention, only the VE based transfusion group will have access to the VE analysis at time of transfusion. The VE results will be used at the discretion of the treating physician based on the VE guided transfusion algorithm. Outcomes include the number and timing of blood products transfused from the time of randomization to 24 hours post randomization and the presence of any 30 day post-transfusion infections.

Eligibility Criteria:
Inclusion Criteria:

* Burn patients admitted to Parkland Hospital with total burn surface area (TBSA) greater than 20%

Exclusion Criteria:

* Patients admitted to Parkland Hospital for reasons other than burns or for burns less than or equal to 20%
Effect of Elderberry Juice on Cognition and Inflammation in Patients With Mild Cognitive Impairment

Elderberries (Sambuci fructus) have been shown in a number of studies to have significant anti-inflammatory and antioxidant effects. Multiple human and animal studies have supported the anti-inflammatory and antioxidant effects of elderberry preparations and it has been used in natural medicine for hundreds of years. Studies examining factors that may decrease the risk of Alzheimer's disease have revealed that drinking juices with similar properties to elderberries is one of the most reliable way to decrease risk. As such the investigators wish to determine the effects of elderberry juice on cognitive decline in a group of subjects at high risk for Alzheimer's disease, those with mild cognitive impairment. Elderberry juice is a commercially available nutritional supplement and easily available to this population.


Eligibility Criteria:
Inclusion Criteria:

* CDR score of 0.5
* MMSE of at least 24
* Age 50 or older

Exclusion Criteria:

* Known history of sensitivity to elderberry products.
* Diabetes.
* Bleeding disorder.
* Current Pregnancy.
* Known allergy to honeysuckle.
* Currently making changes to other drugs that might affect cognitive performance (subjects showing the greatest cognitive decline and other signs of Alzheimer's disease may be prescribed cholinesterase inhibitors as this is a standard of care for Alzheimer's disease but not MCI).
* Presence of any condition the health professional believes will impair ability to complete study procedures (ex. terminal illness, comorbid major psychiatric disorders such as schizophrenia, or drug abuse).
* Potentially confounding neurodegenerative diseases (e.g. MS).