Food Effect on Pharmacokinetic Parameters of ABX464

The goal of this study is to determine the impact of the food on the absorption of the ABX464.

This is a phase I, single-center, open-label, two-treatment, food-effect, randomized study in 40 healthy Caucasian male subjects in order to determine the impact of the food on the absorption of the ABX464.

The two different treatments are the followings:

* Treatment A = 50mg of ABX464 (two 25mg capsules) /Fasted
* Treatment B = 50mg of ABX464 (two 25mg capsules) / Fed

This study consists of two groups:

* Group 1 - single dose assessments, two-period, two-treatment, cross-over: 20 subjects will receive a single dose of 50mg of ABX464 in fed and fasted condition, separated by a wash-out period of at least 45 days.
* Group 2 - multiple dose assessments: 20 subjects will receive 50mg of ABX464 every 3 days during 10 days in fasted or fed condition.

Eligibility Criteria:
Inclusion Criteria:

* Healthy Caucasian male subjects, 18-55 years of age
* Body Mass Index (BMI) of 17-28 kg/m².
* Certified as healthy by a comprehensive clinical assessment (detailed medical history and complete physical examination)
* Normal vital signs after 10 minutes resting in supine position:

  90 mmHg \< systolic blood pressure \< 140 mmHg, 50 mmHg \< diastolic blood pressure \< 90 mmHg, 40 bpm \< heart rate \< 100 bpm.
* Normal automatic 12-lead ECG (incomplete right bundle branch block can be accepted) or judged as non clinically significant.
* Clinical laboratory tests (hematology, blood chemistry, and urinalysis) must be within normal limits or clinically acceptable to Investigator and Sponsor.
* Subjects must be willing to give written informed consent prior to study enrollment and be able to adhere to restrictions and examination schedules.

Exclusion Criteria:

* Individuals with a history of any significant medical disorder which requires a physician's care (cardiovascular, pulmonary, gastro-intestinal, hepatic, renal, metabolic, hematological, neurologic, psychiatric, systemic, or infectious disease; any acute infectious disease or signs of acute illness)
* Frequent headaches and / or migraine, recurrent nausea and / or vomiting (more than twice a month).
* Presence or history of drug allergy, or allergic disease diagnosed and treated by a physician.
* Individuals who have a history of any clinically significant local or systemic infectious disease within 4 weeks prior to drug administration.
* Any individual who does not comply with the requirement that he should not have used any drugs other than paracetamol for at least 2 weeks prior to the study nor alcohol within 48 hours prior to drug administration.
* Individuals who are positive for hepatitis B virus, hepatitis C virus or HIV.
* History or presence of drug or alcohol abuse (positive urine drug screen, positive alcohol breath test).
* Smoking more than 5 cigarettes or equivalent / day, unable to stop smoking during the study.
* Excessive consumption of beverages with xanthine bases (\> 4 cups or glasses / day).
* Subject who will likely be unable to eat entirely the standard high fat breakfast within the allocated time.
* Individuals who have donated blood within the preceding 3 months.
* Individuals who refuse to use an effective method of contraception from the beginning of the study and until 3 months after dosing.
* Individuals with forfeiture of freedom by an administrative or legal obligation or under guardianship