cyrilzakka/clinical-trials huggingface dataset:
Concentrate of Autologous Rich Plasma in Growth Factors in the Treatment of the Thin Endometrium

This study evaluate the percentage of women with thin endometrium who achieve an endometrial thickness equal to or greater than 7 mm after administration of PRGF (plasma rich in growth factors)


Eligibility Criteria:
Inclusion Criteria:

* Women who signed informed consent.
* Women who understand the Spanish language.
* Women under 42 years

Exclusion Criteria:

* Thrombopenia.
* Congenital or acquired uterine malformations that reduce embryo implantation or term gestation.
* Ovarian tumors.
* Benign uterine tumors require surgical treatment
* Local acute inflammatory diseases
* Patients with malignant tumors requiring chemotherapy.
* Patients with acute or chronic infectious or inflammatory diseases requiring active treatment with drugs that may interfere with implantation and gestation.
* Chronic treatment with NSAIDs (Nonsteroidal anti-inflammatory drugs)
Optically Pumped 4He Magnetometers Performances Compared With Medical Reference Methods (ECG and MEG)

Optically Pumped 4He Magnetometers operability for cerebral and cardiac magnetic fields measurement.

Optically Pumped 4He Magnetometers vs reference sensors electrocardiogram (ECG) or SQUIDs data acquisitions

Eligibility Criteria:
Inclusion Criteria:

* more or equal than 18 years old
* patient affiliated to social security or similarly regime
* informed consent form signed
* without cardiac, neurologic, psychiatric or metabolic medical history.

Exclusion Criteria:

* Pregnant women and lactating mothers
* Ward of court or under guardianship
* Adult unable to express their consent
* Person deprived of freedom by judicial or administrative decision
* Person hospitalized without their consent
* Person under legal protection
* Person with any implant
Impact of Therapeutic Education, Being Set up Under the Authorized Program for Diabetics Patients in Hospital

To Assess the impact of therapeutic education on:

* the occurrence of long term diabetes complications .
* balance of his diabetes

evaluation of the benefits of therapeutic education by:

* glycated hemoglobin assay
* telephone monitoring
* quiz
* monitoring of adverse event related to diabete

Eligibility Criteria:
Inclusion Criteria: Patients

* diabetic
* hospitalized in Léon Berard
* with telephone line
* written consent given
* belong to a social security system

Exclusion Criteria:

* no diabetics
* patient having alredy completing a therapeutic education program
* minor patient (\<18 years)
* pregnant woman
* without telephone line
* no belong to a social security system
* patient alredy inclued on clinical study.
* patient tutelage or under curatorship
Bleach and Urine Color in UC Patients Using 5ASA

The aim of this study is to evaluate the effect on urine color by adding household bleach to fresh urine sample among pediatric UC subjects treated with 5ASA

The aim of this study is to evaluate the effect on urine color by adding household bleach to fresh urine sample among pediatric UC subjects treated with 5ASA.

Eligibility Criteria:
Inclusion Criteria:

1. UC patients in remission

Exclusion Criteria:

1. Acute UC exacerbation defined as Pediatric ulcerative colitis activity index (PUCAI) ≥10
2. Any acute or chronic renal disease, either present or past
3. Chronic hypertension, either present or past
4. Regularly receiving other medication that may cause nephrotoxicity - Non-steroidal anti-inflammatory drugs, acetaminophen, anti-epileptics, and antibiotics.
5. Pregnancy
Cone Beam Computed Tomography (CT) Bladder

This study is designed to investigate whether daily images of the pelvis and bladder using a device called a cone beam CT scanner will help to increase the accuracy of radiotherapy treatment. The cone beam CT scanner is a part of the radiotherapy treatment unit. The results of the study may allow patients in the future who are undergoing radiotherapy treatment for bladder cancer to 1) have more accurately directed treatment, 2) have higher doses of radiation delivered to the tumour while keeping doses to the surrounding normal tissues as low as possible. This may allow eradication of the cancer while minimizing side effects of treatment.

This study consists of two phases: Phase A and Phase B. In Phase A, images were collected and analyzed and it was confirmed that it was useful to use the cone beam machine for daily Cone Beam CT Bladder (Phase B)treatment adjustments. In phase B, we hope to be able to use cone beam CT scans to more accurately direct the radiotherapy treatments on a daily basis.

Cone beam computed tomography (CT) is new technology that allows the acquisition of 3-dimensional cross-sectional imaging while the patient is positioned on a linear accelerator couch. Cone beam CT also provides 3D soft tissue volumetric data and therefore important information on daily interfraction movement and deformation of normal critical structures within the pelvis. Visualization of the tumor using this technology may also be enhanced by the additional placement of fiducial markers around the tumor bed to ensure even more accurate targeting. The aim of this study is to assess the feasibility of daily cone beam CT for image guidance in patients receiving radiation therapy (RT) for bladder cancer as well document changes in size and location of the bladder and rectum during an entire course of RT. This will enable us to explore techniques for radiation therapy based on normal tissue avoidance models to reduce treatment toxicity and potentially dose escalation in the future.

Eligibility Criteria:
Inclusion Criteria:

Diagnosis of carcinoma of the bladder

* Patients undergoing radical external beam radiotherapy
* Age \>18 years
* ECOG performance status 0-1
* Informed consent

Exclusion Criteria:

* Inflammatory bowel disease or collagen vascular disease
* Patients undergoing palliative radiotherapy to the bladder
Impact of 'Samalochana' Program on Women Who Have Experienced Intimate Partner Violence (IPV)

Violence has immediate effects on women's health, which in some cases, is fatal. Physical, mental and behavioural health consequences can also persist long after the violence has stopped. Violence against women and girls occurs in every country and culture and is rooted in social and cultural attitudes and norms that privilege men over women and boys over girls.

Research consistently finds that the more severe the abuse, the greater its impact on women's physical and mental health. In addition, the negative health consequences can persist long after abuse has stopped.Present work shares the impact of arsha vidya counselling for women who has been victim of violence.


Eligibility Criteria:
Inclusion Criteria:

* Woman
* Able to attend regular counselling
* Planning to remain in area for next 6 months
* have experience intimate partner violence (physical, emotional, psychological, and/or sexual), including coercive control from a current or former partner in the previous 12 months and no later than 3 years.

Exclusion Criteria:

* Man
* Under 19 years of age
* Cannot attend at regular basis
* Living outside of the selected study sites, or planning to relocate in next 4 months
* Separated more than 3 years ago
Lumbopelvic Movement Control: Effect of Injury History, and the Role of Cortical Control and Its Practical Application 3

Hip and groin pain is a common injury in athletes participating multidirectional sports, and resulting in decreased sports participation and quality of life. The Copenhagen Hip And Groin Outcome Score (HAGOS) specifically targets young to middle-aged physically active individuals with long-standing hip and/ or groin pain, it consists of six separate subscales about symptoms, pain, physical function in daily living, physical function in sports and recreation, participation in physical activities and hip and/ or groin related quality of life (QoL), which all subscales have shown to have adequate validity, reliability and responsiveness in the original version of the questionnaire. Lacking of the specifical questionnaire for physically active people with hip and/or groin pain, the purpose of the study is to translate and cross-culturally adapt HAGOS into Chinese version (HAGOS-C) according to the guidelines from Beaton et al.

Hip and groin pain is a common injury in athletes participating multidirectional sports, and resulting in decreased sports participation and quality of life. The Copenhagen Hip And Groin Outcome Score (HAGOS) specifically targets young to middle-aged physically active individuals with long-standing hip and/ or groin pain, it consists of six separate subscales about symptoms, pain, physical function in daily living, physical function in sports and recreation, participation in physical activities and hip and/ or groin related quality of life (QoL), which all subscales have shown to have adequate validity, reliability and responsiveness in the original version of the questionnaire. Lacking of the specifical questionnaire for physically active people with hip and/or groin pain, the purpose of the study is to translate and cross-culturally adapt HAGOS into Chinese version (HAGOS-C) according to the guidelines from Beaton et al.

We translated the questionnaire from the English version involved following steps: (1)initial translation with two bilingual translators (2) holding consensus meeting for the preliminary Chinese version (3) back translation with other two bilingual back translators (4) another consensus meeting for ensuring the consistency with original English version (5) pretesting for wording and understanding (6) Wording, rephrasing and format corrected to obtain final Chinese version of the HAGOS.

The aim of the study is to determine the validity, reliability and responsiveness of HAGOS-C by recruiting young to middle-aged physically active individuals with long-standing hip and/ or groin pain.

Eligibility Criteria:
Inclusion Criteria:

* physically active at least 2.5 hrs/week
* tenderness on iliopsoas, inguinal, hip adductors, pubic symphysis
* hip and/ or groin pain during motion with restriction or giving way sensation, or clicking sound in hip joint.
* pain lasting for 2 to 6 month and no obvious changes within 3 week recently.

Exclusion Criteria:

* other symptoms in lumbar, knee or ankle joint.
Enthesitis in Patients With Knee Osteoarthritis

The current study was conducted to estimate the prevalence of knee cap enthesitis in patients with knee osteoarthritis and its relation to knee function.

The current study will based on a cross sectional hospital-based survey, conducted among patients with knee osteoarthritis , Knee will assessed for the following items in both sides while Patient lying supine with the knee flexed 40 degrees:

1. Superior pole of the patella - quadriceps tendon enthesis: ● Quadriceps tendon thickness \>6.1 mm ● Suprapatellar bursitis ● Superior pole of patella erosion ● Superior pole of patella enthesophyte.
2. Inferior pole of the patella - proximal patellar ligament enthesis: ● Patellar ligament thickness \>4 mm ● Inferior pole of patella erosion ● Inferior pole of patella enthesophyte.
3. Tibial tuberosity - distal patellar ligament enthesis ● Patellar ligament thickness \>4 mm ● Infrapatellar bursitis ● Tibial tuberosity erosion ● Tibial tuberosity enthesophyte.

Knee functional status was assessed using Knee injury and Osteoarthritis Outcome Score (KOOS) scale for Pain, other Symptoms, Activities of Daily Living (ADL), Sport and Recreation Function (Sport/Rec) and knee-related Quality of Life (QOL). Low knee function was considered if the patient had score 50 or more in any KOOS scale parameter.

Eligibility Criteria:
Inclusion Criteria:

* Primary Knee OA diagnosed according to: American College of Rheumatology Radiologic Criteria for Knee Osteoarthritis.
* Kellegren - Lawrance scale grade II.
* On regular treatment by analgesics, or NSAIDS either topical or systemic.

Exclusion Criteria:

* Recent Knee trauma or intra-articular procedures.
* Previous knee surgery.
* Inflammatory joint diseases, as rheumatoid arthritis, crystal arthritis, and spondyloarthropathy
* chronic systemic diseases that could affect patient functional ability; e.g renal, liver, cardiac impairment, or neurological disorder.
A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty

The objective of this study is to compare the efficacy, safety of DU-176b 30mg or DU-176b 15mg versus enoxaparin sodium for the prevention of venous thromboembolism in patients after elective total hip arthroplasty.


Eligibility Criteria:
Inclusion Criteria:

1. Patients undergoing unilateral total hip arthroplasty
2. Patients who are 20-84 years olds

Exclusion Criteria:

1. Subjects with risks of hemorrhage
2. Subjects with thromboembolic risks
3. Subjects who weigh less than 40 kg
4. Subjects who are pregnant or suspect pregnancy, or subjects who want to become pregnant
Cohort Follow-up: Progression and Consequences of Chronic Kidney Disease.

This study aims to conduct a prospective collection of clinical and para-clinical data in patients with Chronic Renal Diseases to identify disease progression factors, markers of renal function, and the pathophysiology of Chronic Renal Diseases complications.

Chronic Renal Diseases have a growing incidence and prevalence in France, with significant consequences in terms of morbidity and mortality, especially cardiovascular, and Public Health.

It is necessary to know better:

* the mechanisms leading to the progression of the Chronic Renal Diseases
* markers to quantify renal function and progression of the Chronic Renal Diseases
* the pathophysiology of Chronic Renal Diseases complications, cardiovascular, nutritional, or mineral metabolism in particular.

This study aims to conduct a prospective collection of clinical and para-clinical data in patients with Chronic Renal Diseases to identify disease progression factors, markers of renal function, and the pathophysiology of Chronic Renal Diseases complications.

Eligibility Criteria:
Inclusion Criteria:

* Patients with Chronic Renal Disease, stage 2 to 5, non-dialysis patients over the age of 18,
* followed in the Nephrology Department of the Bordeaux University Hospital
* agreeing to participate in NephroTest
* affiliated with social security.

Exclusion Criteria:

* Patients under 18 years
* Patients with acute or rapidly progressive renal failure
* Patients with severe comorbidities or comorbidities that are life-threatening in the short term (\<1 year)
* Patients who did not give their written consent to be included in the study
* Major incapacitated patients and psychiatric patients admitted to hospital
Paracervical Block Versus No Paracervical Block During IUD Insertion

The purpose of this study is to compare the pain level and level of discomfort with paracervical block versus no analgesia in women who present to the University of Texas (UT) Physicians Obstetrics and Gynecology Continuity Clinic, The UT Physicians Women's Center, and the UT Physicians Women's Center- Bellaire for IUD insertion.


Eligibility Criteria:
Inclusion Criteria:

* Women of reproductive age who present for an IUD insertion procedure at the University of Texas Physicians Obstetrics and Gynecology Continuity Clinic, The UT Physicians Women's Center, and the UT Physicians Women's Center- Bellaire for IUD insertion.

Exclusion Criteria:

* Women with current pelvic inflammatory disease (PID)
* Women who are not good candidates for an IUD
* Patients who have a Lidocaine allergy
Treatment of Adults Aged Up to 60 Years With De Novo Acute Myeloblastic Leukaemia,Secondary AML, or RAEB-T

This randomized phase II/III trial investigates the antileukemic activity and toxicity of the FLAG-Ida regimen as a second induction course in patients with acute myeloid leukaemia and bad response to the first induction cycle and/or with a high risk karyotype and compares the antileukemic activity and toxicity of high dose cytarabine/daunorubicin vs. autologous peripheral blood stem cell transplantation as late consolidation therapy in standard risk patients.

Assessment of the antileukemic activity and toxicity of the FLAG-Ida regimen as a second induction course in patients with bad response to the first induction cycle and/or with a high risk karyotype.

Optimization of the late consolidation therapy in standard risk patients (SR) by a prospective randomized trial comparing a high-dose cytarabine/daunorubicin (HD-Ara-C/DNR) based late consolidation therapy with an autologous peripheral blood stem cell transplantation (PBSCT)

Assessment of the antileukemic activity of the different treatment elements by monitoring residual disease (MRD) after induction, early and late consolidation by Real-time PCR

Assessment of the prognostic relevance of minimal residual disease by quantification of the residual leukemic burden in haematological remission by Real-time PCR during follow-up

Eligibility Criteria:
Inclusion Criteria:

* diagnosis of de-novo AML, FAB M 1, 2, 4 - 7
* diagnosis of secondary AML after chemo-/radiotherapy or MDS
* diagnosis of RAEB-T
* age between 16 and 60 years (including 60 years)
* women after exclusion of pregnancy
* written informed consent

Exclusion Criteria:

* patients with severe disease of the heart (e.g. cardial failure NYHA III/IV; history of myocardial infarction within the last 6 months;severe ventricular arrythmias (Lown III to IV)
* patients with DLCO \< 50%
* patients with creatinine clearance \< 60 ml/min
* patients with bilirubin \> 2mg% (34.2 mmol/L)
* patients with severe complications of the leukaemia such as uncontrolled bleeding, pneumonia with hypoxia or shock
* patients with a psychiatric, addictive, or any disorder which compromises ability to give truly informed consent for participating in this study
* HIV positivity
* patients with a t(15;17) translocation
Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts

Warts are benign epidermal tumors caused by human papilloma virus, which are epitheliotropic non-enveloped double stranded DNA viruses. Transmission of warts occurs from direct person-to-person contact or indirectly by fomites . Warts appear in various forms including verruca vulgaris, plane, plantar, filiform, digitate and periungual.

Treatment of warts is difficult for patients and physicians . Currently Available treatment options include cryosurgery, laser, electrosurgery, bleomycin, and topical keratolytic applications; many of them are painful, ineffective, costly and prone for recurrences.

Cryotherapy, which uses liquid nitrogen to freeze tissues and destroy warts, is one of the most common and effective treatments. freezing causes local irritation, leading the host to mount an immune reaction against the virus.

Immunotherapy appears to enhance virus recognition by immune system; allowing clearance of treated wart, distant warts , and helps to prevent infection .Recently, intralesional immunotherapy using different antigens such as mumps, Candida, and tuberculin has been proved effective in the treatment of warts.

The exact mechanism of action of intralesional immunotherapy is still obscure. Intralesional antigen injection probably induces strong non specific inflammatory response against the human papilloma virus-infected cells.

It has been suggested that intralesional measles mumps rubella vaccine results in regression of warts via induction of immune system.

Eligibility Criteria:
Inclusion Criteria:

* Patients should have multiple common or plantar warts.
* No concurrent systemic or topical treatment of warts

Exclusion Criteria:

* patients under 16 years old.

  • Patients with fever or signs of any inflammation or infection.
* Patients with other types of warts.
* Patients with single warts.

  * Pregnancy.
  * Lactation.
  * Immunosuppression.
  * Patients who received any other treatments for their warts in the month before starting study.
  * Past history of asthma, allergic skin disorders, meningitis or convulsions.
Sagittal Knee Kinematics of Transtibial Amputee with Running Blade

Introduction: People with transtibial amputation often suffer musculoskeletal deformities in the form of knee osteoarthritis or osteophytosis due to asymmetric movement patterns and often complain of associated symptoms. Therefore, this study aims to evaluate the sagittal kinematics of the intact and residual knee in the use of Running-Specific Prostheses (RSP), which are increasing in popularity and use among amputees.

Materials and Methods: Participants will be video recorded in the sagittal plane to convert knee flexion motion into angles for the amputee and intact knee and to make measurements using the software's virtual goniometer. Recordings will be taken under the following two conditions: 1) walking at a self-selected walking speed with a Daily Use Prosthesis (DUP); 2) Slow running with RSP. The peak flexion during the swing phase and the initial flexion during the first contact of the stance phase will be recorded as angles in both conditions.


Eligibility Criteria:
Inclusion Criteria:

* body mass index below 30 kg/m2,
* Having unilateral transtibial amputation,
* Being at K4 functional level,
* Having an existing running blade,
* Being able to use RSP integrating it into their DUP,
* Having no self-reported problems with the residual limb or prosthesis, pain or skin lesions,
* Being active recreational runners (at least once a week) for at least 1 and up to 3 months without injury.

Exclusion Criteria:

* Having a history of knee surgery or contracture in the intact/amputee knee.