cyrilzakka/clinical-trials huggingface dataset:
Radiomic Modeling in Differentiating Uncomplicated From Complicated Acute Appendicitis

Non-operative management (NOM) with antibiotics may be a safe alternative to surgery for uncomplicated appendicitis, but preoperative differentiation between uncomplicated and complicated appendicitis is challenging. The study aimed to develop a clinical-radiomics nomogram to distinguish uncomplicated from complicated appendicitis.


Eligibility Criteria:
Inclusion Criteria:

* Pathologically diagnosed as acute appendicitis after appendectomy between January 2021 and December 2022.

Exclusion Criteria:

* age less than 18 years (no upper age limit);
* without CT examination within a week before surgery;
* difficult to outline the contours of the appendix due to inflammatory exudate;
* lack of clinical information.
Endotracheal Extubation With Suctioning Versus Positive Pressure in Children After General Anaesthesia.

Comparing extubation of endotracheal tube in children after general anaesthesia by applying suctioning to the endotracheal tube versus applying positive pressure to the endotracheal tube.

Extubation after general anaesthesia involves removal of the endotracheal tube. This is done by either applying suctioning or applying positive pressure to the endotracheal tube. My study aims at identifying which technique is superior to the other.

Eligibility Criteria:
Inclusion Criteria:

* ASA I/II patients
* either sex
* consent given

Exclusion Criteria:

* not meeting the inclusion criteria
Catheterless Water Vapor Therapy for the Treatment of BPH

The Rezum system is an ablative procedure for patients with benign prostatic hyperplasia (BPH). One of the limitations of the technology is the need for post-operative catheterization up to 5 days. The aim of this study is to assess the feasibility of employing Catheterless Rezum post-operatively in patients with normal or strong bladder contractility. Upon a positive outcome of interim analysis, the effectiveness of Catheterless Rezum will be assessed at five sites for the multicenter phase.


Eligibility Criteria:
Inclusion Criteria:

* Male subject of 40 - 80 years of age
* Has provided informed consent
* Has a diagnosis of bladder outlet obstruction due to benign prostatic enlargement
* Able to complete self-administered questionnaires
* Is a surgical candidate for Rezum
* Has medical record documentation of Qmax \< 15 ml/s
* Has medical record documentation of prostate volume from 30-80 ml by transrectal ultrasound (TRUS)
* Has a bladder contractility index score ≥ 100, calculated by detrusor pressure at Qmax (pDet@qmax) + (5xQmax).
* Willing to undergo pressure-flow studies to calculate BCI prior to surgical intervention.
* Has serum creatinine within the normal range.
* Able to perform intermittent catheterization.

Exclusion Criteria:

* Has a life expectancy \< 2 years
* Is currently enrolled in or plans to enroll in any concurrent drug or device study
* Has an active infection (e.g., urinary tract infection or prostatitis)
* Has a diagnosis of or has received treatment for chronic prostatitis or chronic pelvic pain syndrome (e.g., nonbacterial chronic prostatitis)
* Has been diagnosed with a urethral stricture or bladder neck contracture within the last 180 days
* Has been diagnosed with 2 or more urethral strictures and/or bladder neck contractures within 5 years
* Has a diagnosis of lichen sclerosis
* Has a diagnosis of neurogenic bladder or other neurologic disorder that affects bladder function
* Has a diagnosis of polyneuropathy (e.g., diabetic)
* Has a history of lower urinary tract surgery
* Has a diagnosis of stress urinary incontinence that requires treatment or daily pad or device use
* Has an inability to perform intermittent self-catheterization
* Has been catheterized or has a post-void residual (PVR) of \> 400 ml in the 14 days prior to the surgical procedure
* Has a current diagnosis of bladder stones
Plasma Rich in Growth Factors (PRGF) Treatment for Muscle Tear

the improvement of symptoms and disease progress by the treatment of OA of the knee with PRGF


Eligibility Criteria:
Inclusion Criteria:

* US diagnosed muscle tear
* age 15-40 years old

Exclusion Criteria:

* pregnancy
* mental or physical disabilities
Seroepidemiological Investigation of Coronavirus 2019 (COVID-19) Infection in Gabon

Gabon is the 3rd country most affected by COVID-19 behind Cameroon and Democratic Republic of Congo in Central Africa, with 8860 cases and 54 deaths in critically ill patients, since the first confirmed case of COVID-19 on the 10th of March 2020 (https://africacdc.org/covid-19/). Most of the individuals infected by SARS-CoV-2 are asymptomatic and they represent a major source of viral spread. To date, African countries have been less affected by deaths caused by the Covid-19 pandemic compared to other countries. It is currently unknown why Africa has avoided more deaths and appears to not simply be due to a lack of testing, since the overall death rate has not increased. Better quality data on seroprevalence in different African regions and proven explanations of the differences between Africa and other continents, are urgently needed. The aim of this study is to learn about the proportion of people after a first pic of transmission, who have been exposed to COVID-19 in Gabon by testing for plasma antibodies to the SARS-CoV-2 virus.

The overall goal of this study is to examine the trend of specific anti-SARS-CoV-2 antibodies in Gabonese population.

Based on its technical capacities (ELISA bench and multiparametric flow cytometer), we will provide evident data on the immune responses in Covid-19 infected patients. The quantification of antibodies against SARS-CoV-2 recombinant protein will be done by ELISA using Wantai ELISA total Ab. Meanwhile, data on clinical status will be recorded and classified using WHO patient form. Data obtained will be analyzed by a statistician based at CERMEL using robust models in compliance with the type of data generated.

Eligibility Criteria:
Inclusion Criteria:

* Persons of both sexes aged one year and older and residing for more than three months in the study area are eligible to participate in the study

Exclusion Criteria:

* Any person not residing in the locality surveyed or any person residing for less than three months. Refusal to give informed consent and contraindication to venipuncture venipuncture.
Consumer Knowledge, Attitude, and Behavior Towards Aging Skin

We will conduct a cross-sectional survey from adults 18 years of age and older to examine consumer knowledge, attitudes and behavior towards aging skin.

We will perform a cross-sectional survey study to understand the significance of age-related skin changes to consumers. We will recruit participants through ResearchMatch (a national free and secure online tool) and collect the following data:

Demographic information, including age, gender, race/ethnicity, geographic location, and yearly household income

* How do participants feel towards their own skin and age-related skin changes?
* Which aging-related skin changes are the most significant?
* What factors affect how participants feel towards their skin?
* What role do age-related skin changes play in other aspects of the participants' lives, such as their social and work life?
* What treatments are participants currently seeking, and what are their goals for these treatments?
* How much do they prioritize these treatments?
* What else are they hoping to do?

Using the demographic information, we will also analyze whether there are differences with:

* Age
* Gender identity
* Racial/ethnic identity
* Marital status
* Geographic location
* Yearly household income

Eligibility Criteria:
Inclusion Criteria:

* The study will include English-speaking adults (18 years or older) who voluntarily consent to participate in the survey.

Exclusion Criteria:

* Participants under the age of 18 and non-English speaking participants.
Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia

The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia and dilated ventricles who improve when treated with transcranial monitoring or low ultrasound wave intensity (milliwatts) and with rapid magnetic stimulation which is also a diagnostic tool routinely used by many neurophysiologists. Before, these patients will progress and may need a brain shunt called Ventriculo-peritoneal shunt. He and collaborators now would like to do a double study as this appears to be a cheap and effective alternative treatment and help patients to walk again.

The transcranial monitoring intensity would be equivalent to the well known CLOTBUST study (\<300mw/sq cm)for one hour, using two probes.

All will be treated as an outpatient and there is no form of infusion or interventional treatment.

The rapid magnetic stimulation is at about 50a/us, 15Hz, 1000 pulses with 10 sec pause for ten days along the skull vault. Informed consent will be obtained. 30 patients will be recruited and sham treatment would be just applying probe without power for transcranial and for magnetic stimulation coil will be angled away. Data will be compiled by a separate blinded investigator and so with the statistics. VP shunt failure patients, which is common, will be included. Barthel's daily living index and standard cognitive tests will be used to assess results.

Eligibility Criteria:
Inclusion Criteria:

* cerebral ischemia with our without hydrocephalus and gait apraxia

Exclusion Criteria:

* all other conditions which contribute to walking difficulty e.g. bad knees; or spondylosis; parkinson's or paralytic strokes
Phase IIa Vorinostat (MK0683, Suberoylanilide Hydroxamic Acid (SAHA)) Study in Lower Risk Myelodysplastic Syndromes (0683-064)

This study is to evaluate the efficacy, safety and tolerability of vorinostat in patients with lower risk Myelodysplastic Syndrome (MDS).


Eligibility Criteria:
Inclusion Criteria:

Patient is a male or female, at least 18 years of age with low or intermediate-1 risk Myelodysplastic Syndrome (MDS) defined by the International Prognostic Scoring System

* Patient has previously untreated disease, or has received up to one prior treatment regimen for lower-risk Myelodysplastic Syndrome
* Patient has a performance status of equal to or less than 2 on the Eastern Cooperative Oncology Group Performance Scale
* Patient must have adequate organ function

Exclusion Criteria:

* Patient has clinical evidence of Central Nervous System (CNS) leukemia
* Patient is pregnant or breastfeeding, or expecting to conceive within the projected duration of the study
* Patient had prior treatment with a histone deacetylase inhibitor
Sex Selection of Human Spermatozoa

This study aims to demonstrate a reliable method of selecting gender specific sperm. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient layers. The selected gender specimen will then be utilized for assisted reproductive fertilization- in vitro fertilization or intrauterine insemination which are routine standard of care procedures.

The study aim is to test a simple, reliable, and inexpensive method to attempt selection of gender specific spermatozoa. Couples will undergo evaluation and treatment according to the standard clinic procedures. Sperm samples provided for infertility treatment will be further analyzed routine semen analysis for volume, concentration, mobility and morphology. Sperm samples will be provided by consenting males undergoing infertility treatment. A multilayer density gradient will be performed utilizing an FDA approved solution, Enhance-S Plus Cell Isolation Media (Vitrolife, San Diego, CA).

This density gradient is also used for standard semen preparation for intrauterine insemination. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient fractions. Sperm suspensions will be smeared on slides for FISH analysis using centromeric probes for chromosomes 18, X, and Y. The ratio of X- to Y- chromosome bearing spermatozoa will be assessed as a percentage on at least 200 cells per slide. Aneuploid cells and those without signals will be omitted. Unselected fractions of each sample will serve as controls. The rate of X-bearing spermatozoa after 4-layer density gradient will be calculated. After thorough counseling, the selected preconception gender specimen will then be utilized for assisted reproductive fertilization- in vitro fertilization with or without intracytoplasmic sperm injection (ICSI) or intra uterine insemination which are routine standard of care procedures.

Eligibility Criteria:
Inclusion Criteria:

* Couples undergoing infertility treatment with IVF or insemination seeking gender specific offspring for medical and non medical reasons

Exclusion Criteria:

* Severe male factor
The Treatment Challenges and Limitation in High-Voltage Pediatric Electrical Burn at Rural Area

A case of high-voltage pediatric electrical burn involving a fully conscious 13-year old boy who was admitted to the emergency room after being electrocuted by high-voltage power cable, with superficial partial thickness burn over right arm, trunk, and left leg (26% of total body surface area) with cardiac abnormality e.g. tachycardia and non-specific ST depression. Treatments were based on Australian New Zealand Burns Association algorithm with several modifications, i.e. administering lower concentration of oxygen with nasal cannula instead of non-rebreathing mask and intravenous Ketorolac and Metamizole as analgesic instead of morphine due to limitation in infrastructure and knowledge. The patient underwent surgical debridement and strict observation with no signs of abnormality found during hospital stay. Wound dressing consisted of silver sulfadiazine, Sofra-tulle® and dry sterile gauze were used until epithelialization. After the wound healed, the patient resumed wearing elastic bandage and moisturizer on the wound area. The patient was observed daily through 7 days of hospitalization and followed-up for 1 year, achieving normal physiologic function of the affected area but unsatisfactory esthetic result. This case report showed that there is still a lack of burn prevention programs in the rural area, resulted in inadequate first aid application for electrical burn. There is a need for acknowledging and maximizing the implementation of available standardized guidelines e.g. Australian New Zealand Burns Association by giving homogenized training to personnel as well as providing feasible equipment, and then followed by strict monitoring for the patient. The focus of the burn program should also include burn rehabilitation, psychosocial needs and any complaints needing expert opinion in an outpatient setting in addition to adequate burn management for life saving and good wound healing.


Eligibility Criteria:
Inclusion Criteria:

* patient with acute electrical burn wound

Exclusion Criteria:

* patient does not want to participate
Obstructive Sleep Apnea Syndrome: Evaluation of the Efficacy of Sleepinnov© (Spiri+) Continuous Positive Airway Pressure Device

Continuous Positive Airway Pressure (CPAP) is the reference treatment of patients suffering from Obstructive Sleep Apnea Syndrome (OSAS).This device functions as a pneumatic stent that stabilizes the upper airway, prevents periodic collapses during sleep.The correction of abnormal respiratory events during sleep allows improvement of symptoms related to OSAS and restores quality of life.The purpose of this study is to validate the efficacy of a new CPAP brand developed by Sleepinnov©.

Obstructive sleep apnea syndrome (OSAS) is characterized by the repetitive occurrence of partial or complete pharyngeal obstructions during sleep.Continuous Positive Airway Pressure (CPAP) is the first line treatment of OSAS.

The aim of the prospective monocentric two steps pilot study SPIRI+ is to validate the efficacy of a new CPAP brand developed by Sleepinnov©.

* the first step will validate the capability of the algorithm to appropriately detect of abnormal repiratory events during sleep.the metrics will be a comparison of the total number of events detected by the CPAP Sleepinnov© with data arising from a concurrent polysomnography.
* the second step will check overall clinical efficacy of the new CPAP device by assessing the percentage of OSAS with an index of residual events below 10 and 5 per hour.

Eligibility Criteria:
Inclusion Criteria:

* newly diagnosed and untreated Obstructive sleep apnea syndrome (IAH \>15/hour) with an indication of treatment with CPAP
* Patients who have given their informed written consent

Exclusion Criteria:

* Pregnant or lactating women
* Patients not affiliated to the French social security system or equivalent
* Patient deprived of liberty by judicial or administrative decision
* Patients under guardianship or curatorship
Prospective Comparison of Breast MRI vs Contrast Mammography Prior to Surgery in Breast Cancer Patients

In current clinical practice, women with biopsy proven breast cancer can be sent for breast magnetic resonance imaging (MRI) or contrast enhanced mammography (CEM) prior to surgery in order to delineate the extent of a known cancer and / or assess for the presence of occult secondary cancers. This study seeks to compare the global costs (based on actual reimbursement rates) of CEM/breast MRI, downstream imaging testing, and diagnostic procedures in women randomized to breast MRI versus CEM. Secondary goals are to compare patient preferences for CEM vs MRI and clinically relevant outcomes (e.g. conversion from lumpectormy to mastecomy).

This is a pilot randomized controlled trial comparing the global costs of two standard of care imaging techniques in patients with a new breast cancer diagnosis and planned breast conservation surgery. Patients enrolled in this study will be randomized to either CEM or breast MRI. The purpose of this study is to compare the global costs (based on actual reimbursement rates) of initial imaging modality (CEM or breast MRI), downstream imaging related to breast cancer evaluation, and diagnostic breast procedures in women randomized to breast MRI versus CEM.

Secondary endpoints include assessment of patient's reported satisfaction with the initial imaging technique received (CEM versus MRI), quantifying differences in health-related quality of life (as assessed by the patient reported Euro quality of life 5D questionnaire), rate of conversion from planned lumpectomy to mastectomy, and rate of re-operation for positive margins.

Eligibility Criteria:
Inclusion Criteria:

* Women aged 18 years or older with newly diagnosed breast cancer and planned breast conservation surgery
* Clinically indicated referral for breast MRI or contrast mammogram prior to surgery
* Provision of informed consent

Exclusion Criteria:

* Planned neoadjuvant chemotherapy
* Patients that are medically unstable
* Pregnancy
* Patients with known contraindication to contrast mammography, including:

  * Glomerular filtration rate \<30
  * Known adverse reaction to iodinated contrast material
* Patients with known contraindication to Breast MRI including:

  * Glomerular filtration rate \<30
  * Known adverse reaction to gadolinium contrast material
  * Non-MRI conditional device or catheter
  * Brain aneurysm clip implanted before 1995
  * Cochlear implant
  * Ocular foreign body (e.g. metal shavings)
  * Insulin pump
* Patients unable to read and understand English or Spanish (i.e. an inability to complete study questionnaires)
Postoperative Pain After Dental Post Application

In this study the effect of dental post application on postoperative dental pain in patients with asymptomatic teeth after a single-appointment root canal treatment will be evaluated.

The aim of this clinical study is to evaluate the effect of dental post application on postoperative pain intensity level in patients with asymptomatic teeth after a single-appointment root canal treatment. A total of one hundred patients with asymptomatic teeth and with no contradictory medical history who are indicated for non-surgical root canal treatment and application of a dental post at the Endodontic Clinic, Faculty of Dentistry, Istanbul Medipol University, between April and December of 2019 will be included. All of the patients will be recruited from the Istanbul Medipol University Dental Clinics in Istanbul. the patients will be divided in two groups (n=50). Consent will be obtained from all study participants before the treatment. After the root canal treatments are completed in single-visit, in the first groups dental posts will be applied immediately at the same visit and patients will be appointed for pain assessment. In group 2 after the root canal treatment a temporary filling be applied in the access cavity and patients will be appointed for pain assessment. Dental posts will be applied after the pain assessment is completed at the end of 1 week. All treatments will be performed by one endodontist. Postoperative pain intensity will be assessed at 24, 48, and 72 h; 7 days; after the treatment. The teeth will be examined according to postoperative pain intensity levels,

Eligibility Criteria:
Inclusion Criteria:

* patients with asymptomatic teeth which were in need of orthograde non-surgical root canal treatment with post application

Exclusion Criteria:

Patients

* who were younger than 18 years old,
* who had contradictory medical history for root canal treatment,
* who used antibiotics 1 month prior and analgesics 1 week prior to the treatment,
* who could not abide the follow-up time Teeth
* that were symptomatic
* with previous root canal treatment
* with present or suspected vertical root fracture
* with ≥ 4 mm periodontal pocket depth
* with apical lesions ≥ 5mm
* with damaged or resorbed apex
* that were in need of apical surgery