cyrilzakka/clinical-trials huggingface dataset:
Computer Aided Detection of Polyps During Colonoscopy Procedures

The focus of the study is to evaluate impact on Adenomas Per Colonoscopy (APC) with a Computer Aided Detection (CAD) software assisting the gastroenterologist during a colonoscopy procedure.

The details of the proposed study are as follows:

1. Colonoscopy will be performed in the same standard of care manner as if no study was taking place. The video signal from the colonoscope will be fed into a computer running the EndoVigilant CAD software in addition to the standard video output to the procedure monitor. The EndoVigilant CAD software will display an annotated video on an additional monitor that includes both the colonoscopy picture and annotation by the software indicating the location of any polyps on the screen.
2. The endoscopist performing the procedure will therefore be able to observe a standard colonoscopy video on the primary monitor and the annotated video on the second monitor.
3. The endoscopist will primarily rely on the second monitor (augmented with annotation from EndoVigilant ColonCAD software) but the standard procedure monitor will be always operational and available for maneuvers such as fast insertion, polypectomy etc.

Eligibility Criteria:
Inclusion Criteria:

* Patient presenting for routine colonoscopy for screening and/or surveillance purposes
* Ability to provide written, informed consent and understand the responsibilities of study participation

Exclusion Criteria:

* Patients with diminished cognitive capacity
* Patients with inflammatory bowel disease, ulcerative colitis or Crohn's colitis
* Patients with incomplete colonoscopies (due to technical difficulties or poor bowel prep)
Sitagliptin Versus Insulin Dose Increase in Type 2 Diabetes on Insulin Treatment

It is well established that inhibition of dipeptidyl peptidase (DPP)-IV reduces glucose levels and preserves pancreatic beta cell function in patients with type 2 diabetes. DPP-IV inhibitors stimulate insulin secretion as well as insulin biosynthesis and inhibit glucagon secretion from pancreas by increasing incretin (GLP-1) levels. Recent studies reported that combination therapy with DPP-IV inhibitors and other oral antidiabetic medication have additive or synergistic effects in lowering glycose level, preserving beta-cell mass and function as well as enhancing insulin sensitivity. However, there have been few studies about the glucose lowering effect of DPP-IV inhibitors in patients with type 2 diabetes on insulin treatment.

The researchers hypothesized that DPP-IV inhibitor add-on therapy to insulin treatment may have favorable effects on glucose control and endogenous insulin secretory function in type 2 diabetic patients. The researchers plan to compare between sitagliptin (DPP-IV inhibitor) add-on therapy and insulin dose increase therapy in uncontrolled type 2 diabetes on insulin treatment.


Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetes
* HbA1c ≥ 7%
* Age ≥ 18
* Insulin treatment with or without oral antidiabetic medication

Exclusion Criteria:

* Contraindication to sitagliptin
* Pregnant or breast feeding women
* Type 1 diabetes, gestational diabetes, or diabetes with secondary cause
* Chronic hepatitis B or C (except healthy carrier of HBV), liver disease (AST/ALT \> 3-fold the upper limit of normal)
* Renal failure (Cr \> 2.0)
* Cancer within 5 years
* Not appropriate for oral antidiabetic agent
* Medication which affect glycemic control
* Disease which affect efficacy and safety of drugs
* Other clinical trial within 30 days
Effect of Caffeine on Heart Function

* The primary objective of this study is to assess the effect of an energy drink on ventricular repolarization as measured by the interval between the cardiac Q wave and the cardiac T wave (QT interval)obtained from the body surface ECG.
* The secondary objective is to assess the effects of an energy drink on heart rate and blood pressure (hemodynamic effects).

To place the observed changes in context, comparison will be made to a commonly consumed drink, coffee: Starbuck's K-cup Breakfast Blend.

This study will assess cardiac repolarization before and after three conditions each of which will involve the subject drinking beverages of varying caffeine content.

Eligibility Criteria:
Inclusion Criteria:

* Healthy
* BMI between 24 - 29

Exclusion Criteria:

* Resting heart rate below 60 bpm
* Resting heart rate above 88 bpm
* Cardiovascular or metabolic disease
The Effect Of Somatosensory Perceptıon And Proprıoceptıon On Upper Extremıty Functıonal Skılls

Cerebral Palsy (CP) is a non-progressive neurodevelopmental disorder characterized by posture and movement disorders as a result of damage to the immature brain for any reason before, during or after birth.In addition to tone, postural and neuromuscular control in children with Cerebral Palsy; Problems are also observed in communication skills, perceptual and cognitive systems and sensory systems.

In neurodevelopmental theory, sensory and motor systems mutually support the development of each other. In addition to the motor problems observed in SP; Sensory-motor impairment, which occurs with the effects of systems such as proprioception, tactile (touch), and vestibular (balance), emerges as the main problem. With the involvement of the central nervous system (CNS) in CP, the sensory systems are also affected along with the motor systems. The involvement of the sensory system is seen in 45% of these children and presents with a white matter lesion. One of the important factors affecting the activities of daily living (ADL) in children with Cerebral Palsy is the deficiencies in their functions as a result of the affected upper extremity. Deficiencies in sensory input can cause delays in learning new motor movements. This can result in disuse of the extremities and sensitivity. The somatosensory cortex, which is important for sensory integration; It is the area of the brain that is sensitive to tactile sensations from the body. It is known that the somatosensory system, which carries these tactile stimuli to the somatosensory cortex, is active from the early stage of life. Sensory and motor interactions experienced in the early stages of life are important for motor development even in the early stages. The improvement in measurable cortical responses of the tactile system; It starts from the 8th week of intrauterine and continues until the postpartum period. In the newborn period, the infant's responses to tactile and proprioceptive stimuli play an important role in the development of motor, cognitive, social and communication skills during infancy and early childhood. The aim of this study is to investigate the effects of somatosensory perception and proprioception on upper extremity functional skills in children with hemiparetic and diparetic CP.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with Hemiparetic and Diparetic CP with Gross Motor Function Classification System (GMFCS) Level ≤ 3
* Children with ≤ 2 upper extremity muscles according to the Modified Ashworth Scale (MAS)
* Children with Manual Skills Classification System (MACS) ≤ 3
* Not being diagnosed with mental disability by the RAM (Guidance Research Center)
* Children with CP aged 6-18 years
* Not receiving surgery or Botox (Botulinum Toxin) treatment in the last 6 months
* Children with CP with parental approval

Exclusion Criteria:

* Joint contracture in the shoulder, elbow and hand-wrist
* Having any hearing or vision problems
Correlation Between Micro Vascular Complications and Severity of Coronary Artery Disease in Type 2 DM

Diabetes is a major cause of morbidity and mortality worldwide and it contributes substantially to healthcare costs. Type 2 Diabetes mellitus is the most common type of diabetes accounting for approximately (90%) of all cases.

Type 2 DM carries a two to six times risk of death from cardiovascular etiologies, such that age adjusted prevalence of white Americans for coronary artery disease (CAD) is double in those with type 2 DM than those without .


Eligibility Criteria:
Inclusion Criteria:

100 Cases were selected with type II (DM) patients who had been admitted for coronary angiography because of suspected (CAD) to the Catheter lab unit of Sohag University Hospital.

Exclusion Criteria:

1. Type 1 DM.
2. Smoker.
3. Hypertension.
4. Pregnant women.
5. Patient known non diabetic retinal disease non diabetic. nephropathy or neuropathy.
6. History of familial dyslipidemia.
Healthy University Bern Through Yoga - A Worksite Wellness Intervention

This study aims to research the effect of a 8-week long worksite yoga intervention on the perceived health of the University of Bern employees. Furthermore, in light of the current transition to online options, this study will compare the effects of yoga classes attended in person to those attended online.

After giving informed consent, the participants of the study will be randomly assigned to the intervention or waiting list control group. The intervention group will take part in a 8-week long yoga program before the christmas break, while the waiting list control group will receive the same intervention at the beginning of the new year. For both time periods the participants will be randomly assigned to the in person or the online group.

There will be four measurement times when all the participants will be asked to fill out an online questionnaire before and after both implementations of the intervention. The questionnaires include demographic data, perceived health (SF-8), perceived stress (PSS), well-being (BIT), physical activity questionaire (Godin Leisure-Time Exercise Questionnaire) as well as a questionnaire concerning the satisfaction of the intervention after the participants have actively taken part in the yoga intervention.

Eligibility Criteria:
Inclusion Criteria:

* Employee of the University of Bern
* Understanding German
* Ability to participate in 8 yoga classes

Exclusion Criteria:

-
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament

The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis.

The main question\[s\] it aims to answer are:

• Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.

The aim of the present study is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis. The evaluation is to be done using quantitative microbiological assessment from samples extracted from root canals before and after intracanal medicament placement in roots of permanent molars, having PAI score ≥ 2.

Eligibility Criteria:
Inclusion Criteria:

* Patients with teeth diagnosed with apical periodontitis
* Periapical Index (PAI) ≥ 2
* The teeth are restorable

Exclusion Criteria:

* Teeth with immature roots
* Non restorable teeth
* Medically compromised patients with systemic complication that would alter the treatment.
* Teeth with internal/external root resorption
* Patient with an allergy to diclofenac sodium
Innovation Oncological Rehabilitation: Applicability of the Different Techniques Physiotherapeutic Post Breast Cancer

The aim of this study is to evaluate the effects and validate news physiotherapy techniques: robotic rehabilitation, virtual reality, vibration therapy, canoeing and hand cycling in the secondary clinical complications of the breast cancer, through the Biomedical Instrumentation. It will be realized the double-blind longitudinal clinical study. Will participate in the study 100 women post breast cancer surgery, the volunteers will be allocated in the respective modalities treatment; and 20 healthy volunteers, will be only the control group. The volunteers conducted 10 physiotherapy session, and it will be evaluated after, during and before of the treatment, to evaluated myoelectric activity, scapular and hand muscle strength, range of motion, circumference of the upper limbs and quality of life. Expected to Positive Results With regard to the minimization of pain intensity and lymphedema, favoring the improvement of range of motion of the shoulder joint, myoelectric activity, increased muscle strength, and consequently improves the quality of life.

The brest cancer is considered a public health problem worldwide. In Brazil, there was increased survival due to advances in early diagnosis and the therapeutic approaches each more accurate and effective, however these women require care and attention for short and long time, due to the consequences physical and psychosocial, que undertake their quality of life. The innovative techniques physiotherapy treatment can contribute to the prevention and treatment of complications, with the intention to facilitate the early return of women to their daily activities. The aim of this study is to evaluate the effects and validate news physiotherapy techniques: robotic rehabilitation, virtual reality, vibration therapy, canoeing and hand cycling in the secondary clinical complications of the breast cancer, through the Biomedical Instrumentation. It will be realized the double-blind longitudinal clinical study. Will participate in the study 100 women post breast cancer surgery, the volunteers will be allocated in the respective modalities treatment; and 20 healthy volunteers, will be only the control group. The volunteers conducted 10 physiotherapy session, and it will be evaluated after, during and before of the treatment, to evaluated myoelectric activity, scapular and hand muscle strength, range of motion, circumference of the upper limbs and quality of life. Expected to Positive Results With regard to the minimization of pain intensity and lymphedema, favoring the improvement of range of motion of the shoulder joint, myoelectric activity, increased muscle strength, and consequently improves the quality of life.

Eligibility Criteria:
Inclusion Criteria:

* Conservative or non-conservative breast cancer surgery;
* Acceptance of the Informed Consent.

Exclusion Criteria:

* Patients who still have chest drain;
* Volunteers who need any aiding device to remain in orthostatism;
* Patients don't accepted of the Informed Consent;
* Patients who ar afraid of water.
Inspiratory Muscle Training in Mechanically Ventilated Patients in Intensive Care Unit

In addition to conventional chest physiotherapy, inspiratory muscle training will be applied in mechanically ventilated intensive care patients. It is aimed to examine the effects of inspiratory muscle training on respiratory muscle strength, diaphragm thickness, and diaphragm excursion in intubated or tracheostomized patients with mechanical ventilation in the intensive care unit.

Subjects who mechanically ventilated in the intensive care unit will be divided two groups. Study group will recieve inspiratory muscle training in addition to convantional chest physiotherapy. Control group will recieve convantional chest physiotherapy. Training will continue until discharge or until the 21st day of the training. Respiratory muscle strength, diaphragm thickness and diaphragm excursion were measured before training and before discharge.

Eligibility Criteria:
Inclusion Criteria:

* ≥18 years of age
* hemodynamic stability and alert
* able to spontaneously trigger the ventilator and perform at least one command for activation of respiratory muscles
* required mechanical ventilation support with continuous spontaneous ventilation mode or pressure- or volume-controlled intermittent mandatory ventilation (6 breaths/min) mode
* required pressure support ≤ 15 cmH2O and PEEP ≤ 10 cmH2O
* unable to breathe without support for 72 consecutive hours following the resolution of factors leading to respiratory failure
* FiO2 of 0.5 or less
* PaO2 greater than 60 mmHg and capable of sufficient gas exchange

Exclusion Criteria:

* cooperation disorder
* trauma or deformity related to the thorax that affect respiration
* progressive neuromuscular disease
* excessive bronchial secretion (requiring more than one suctioning per hour)
* need for continued sedative or analgesic agents
* use of home-type mechanical ventilation before admission to the hospital
* cardiac, pulmonary, or other conditions leading to impaired stability
* impaired cooperation, compliance, and motivation
CMV-MVA Triplex Vac.Enhance Adap. NK Cell Recon. After Auto HSCT in pt Lymphoid Malig

This is a prospective, interventional study administering 2 doses of the experimental vaccine (CMV-MVA Triplex) to 20 evaluable patients (10 CMV-seropositive and 10 seronegative) undergoing autologous hematopoietic cell transplantation (HCT) for lymphoma or myeloma on days 28 and 56 post-HCT. The absolute number of adaptive NK cells (CD56dimCD57+NKG2C+) at various days will be compared.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years
* Lymphoma or multiple myeloma
* Planned co-enrollment on current (at the time of this study version) or future (opening subsequent to this study) standard of care autologous stem cell transplant protocol.

  \* Must meet all eligibility requirements of the co-enrolled parent study
* Sexually active females of childbearing potential and males with partners of child-bearing potential must agree to use adequate birth control until at least day 100 post-HCT
* Voluntary written consent signed before performance of any study-related procedure not part of normal medical care

Exclusion Criteria:

* CMV immunoglobulin, valganciclovir, ganciclovir, foscarnet, or other anti-CMV therapy within 3 months before the first vaccine is planned. Acyclovir and valacyclovir are allowed.
* Pregnant or breast feeding. The FDA has not classified this agent into a specified pregnancy category. Females of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy
* Planned immunotherapy post-HCT. Proteasome inhibitors and/or immunomodulators, such as but not limited to Lenalidomide or Pomalidomide, used for myeloma maintenance are allowed.
Multi-Modality Imaging Standard Cohort Of Cerebrovascular Disease

The aim of this study is to establish a multi-center and multi-modality imaging standard cohort of cerebrovascular disease, analyze the potential mechanisms affecting the prognosis of cerebrovascular disease based on a variety of imaging methods, and explore potential therapeutic targets.

Cerebrovascular diseases are major diseases that pose a serious threat to human health and life, and have become the leading cause of death from disease among Chinese residents. Despite the best medical or surgical treatment options, many patients still suffer from functional disabilities, imposing a heavy burden on families and society. Identifying the complex and delicate changes in brain neural activity, blood flow, oxygenation, and metabolism following the occurrence of cerebrovascular diseases can not only explore the potential mechanisms underlying poor functional prognosis, but also provide a scientific basis for targeted treatment strategies. This study is a consecutive, multicenter, prospective registration study that recruits approximately 800 patients with cerebrovascular diseases (both hemorrhagic and ischemic stroke) aged 18-80 years within 7 days of onset. The study collects baseline information and imaging data including head CT, MRI, TCD, fNIRS, and ophthalmic testing. The primary endpoint event was functional outcome 3 months (mRS score). Secondary outcomes were in-hospital complications (including stroke progression, recurrence, and mortality), cognitive disorder, functional outcomes, recurrent stroke, new vascular events, and all-cause death at 3, 6 and 12 months .

Eligibility Criteria:
Inclusion Criteria:

* Age between 18 and 80 years old;
* Onset of symptoms within 7 days;
* Clinical diagnosis of cerebrovascular disease (ischemic stroke or hemorrhagic stroke) confirmed by head imaging (CT or MRI);
* Signed informed consent form.

Exclusion Criteria:

* Diagnosed with non-cerebrovascular diseases (such as central nervous system infections, epilepsy, and metabolic encephalopathy);
* Patients with contraindications to multimodal CT or MRI, functional near-infrared imaging, or those who cannot cooperate to complete the relevant examinations;
* Patients with a life expectancy of less than 3 months or those who cannot complete the study follow-up due to other reasons.
The Effect of Remote Postconditioning on Graft Function in Patients Undergoing Living-related Kidney Transplantation

The purpose of this study is to investigate whether upper limb ischemic postconditioning can improve renal function and decrease ischemic-reperfusion injury in patients undergoing living donor kidney transplantation.

Ischemic reperfusion injury after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. To reduce the adverse effect of ischemic reperfusion injury after organ transplantation, various strategies including ischemic preconditioning or postconditioning. Remote ischemic postconditioning is one of such strategies where brief ischemic reperfusion injury of one organ protects other organs from sustained ischemic reperfusion injury. Remote ischemic postconditioning of the limb with a tourniquet is a safe and convenient method of postconditioning organs against ischemic reperfusion injury. However, the efficacy of remote ischemic postconditioning in patients undergoing living donor kidney transplantation needs to be established. Therefore, we investigate the efficacy of remote ischemic postconditioning of the upper limb with a tourniquet in recipients of kidney transplantation by measuring the markers of acute kidney injury.

Eligibility Criteria:
Inclusion Criteria:

* Subjects undergoing elective living donor kidney transplantation
* subjects older than 20 yrs who can give written informed consent

Exclusion Criteria:

* re-transplant recipients
* those with peripheral vascular disease affecting the upper limbs free of arteriovenous fistula