cyrilzakka/clinical-trials huggingface dataset:
Late Clinical Events Associated With COVID-19 Infection

Several publications document the occurrence of symptoms that persist or occur late.

The identification of the observed clinical manifestations and their clinical and paraclinical description are essential to better understand the natural evolution of COVID-19, to clarify the pathophysiological mechanism of these possible late manifestations, and to identify potential management options for patients.

Since this type of event is infrequent, a large-scale national multicenter cohort study focusing on symptomatic patients is needed.

Several publications document the occurrence of symptoms that persist or occur late, more than 3 weeks after the first clinical manifestations of an SARS-COV2 infection. These manifestations may be related to thromboembolic or inflammatory complications, superinfections, or other mechanisms not yet well understood, including potentially related to the persistence of SARS-COV2. The identification of the observed clinical manifestations and their clinical and paraclinical description are essential to better understand the natural evolution of COVID-19, to clarify the pathophysiological mechanism of these possible late manifestations, and to identify potential management options for patients.

Since this type of event is infrequent, a large-scale national multicenter cohort study focusing on symptomatic patients is needed. In parallel, the prevalence of the main symptoms observed more than 3 weeks after the onset of a COVID-19 will be estimated through partnerships with existing cohort studies in the general population or in the population followed for COVID-19, still symptomatic or not at 3 weeks of infection.

Longitudinal implementation of bio-libraries will allow this cohort to also constitute a bridge between clinicians and researchers.

Eligibility Criteria:
Inclusion Criteria:

* History of symptomatic CoV-2-SARS infection as defined by :

  o Positive RT-PCR SARS-CoV-2 RT-PCR result OR positive SARS-CoV-2 serology

  o Associated with at least one event : x Anosmia occurring after February 2020 x OR COVID 19 evocative scanner x OR ≥ 2 contemporary symptoms of the virological sample from: asthenia, cough, dyspnea, fever, myalgia, dysgeusia, diarrhea AND not present prior to diagnosis
* AND persistence of at least one symptom present in the first 3 weeks of a COVID-19, more than 8 weeks away from the first symptoms of COVID-19. OR late onset of at least one new symptom a minimum of 3 weeks and a maximum of 6 months after the first symptoms of a CoV-2 SARS infection.
* First symptoms less than 6 months old on the day of inclusion
* To benefit from a State Health Insurance or Medical Aid plan
* Have signed an informed consent for inclusion.

Exclusion Criteria:

* Minor patient
* Patient under protection of justice
* Patient who required intensive care management :

  * more than 5 days
  * OR requiring orotracheal intubation
  * OR having required high flow ventilation (optiflow)
Respiratory Physiotherapy in Mechanical Ventilation

This study aimed to evaluate the effect of respiratory physiotherapy that is breathing exercise during weaning on ventilated patients in ICU.

Respiratory physiotherapy is a treatment approach to increase ventilation and function in patients with acute and chronic problems and to reduce respiratory work and dyspnea.Airway cleaning techniques, lung volume-enhancing approaches, thoracic mobilization, positioning, breathing exercises and inhalation therapy are among the strategies used.

In patients with invasive MV support, respiratory physiotherapy is the position, tracheal cleaning and inhalation therapy when necessary. But breathing exercises are not indicated in the acute phase. In the process of weaning, inspiratory muscle training and breathing exercises can be used.

Eligibility Criteria:
Inclusion Criteria:

* weaning period of patients in invasive mechanical ventilation
* patients in stable hemodynamic parameters

Exclusion Criteria:

* under 18 years old
* pregnant
* non-cooperative
Creative Arts Diabetes Initiative for Youth/Young Adults Transitioning to Adult Care

The Creative Arts Diabetes Initiative will offer facilitated art therapy with a group/peer-support environment to two groups of youth/young adults, one with type 1 diabetes, and one with type 2 diabetes. This environment intends to "meet youth where they are", promote universality, hope and self-understanding, has the potential to be therapeutic and allows youth to express and learn about themselves and each other while developing healthy coping skills and address their fears and concerns.

The Creative Arts Diabetes Initiative will offer facilitated art therapy with a group/peer-support environment to two groups of youth/young adults, one with type 1 diabetes, and one with type 2 diabetes. This environment intends to "meet youth where they are", promote universality, hope and self-understanding, has the potential to be therapeutic and allows youth to express and learn about themselves and each other while developing healthy coping skills and address their fears and concerns.

As much of diabetes management is about meeting physical health goals - it is the vision of this study that offering additional support in the form of art therapy will have positive effects for bringing awareness and avenues for self-care to the other often neglected dimensions of patients' mental, emotional and spiritual health as part of a more holistic health process.

Engaging in art therapy has the potential to decrease diabetes related distress by giving youth a means and opportunity to identify, understand and express their feelings about having diabetes. Improved self-awareness and self-reflectiveness can help youth integrate their feelings and learn how this can motivate, influence and impact their behaviors and life choices.

Youth will have the opportunity for engaging in peer support, and to build relationships that are meaningful, thus increasing their sense of belonging and positively affect their level of self-confidence, purpose and wellbeing.

Eligibility Criteria:
Inclusion Criteria:

* diagnosed with either type 1 or type 2 diabetes, live within weekly travel distance to Winnipeg, Manitoba, receive their pediatric care at the Diabetes Education Resource for Children and Adolescents, or who are members of the Maestro Project

Exclusion Criteria:

* those who cannot give informed consent or who are not able to attend regular sessions due to travel distance
Comprehensive Imaging of Perforator Vessels and Subcutaneous Vascular Network With No-Exogenous Contrast and Non-Ionizing-Radiation Magnetic Resonance Angiography

In this study the investigators plan to enroll a total of 25 evaluable volunteers (volunteer population) for the development and optimization of perforator imaging protocols and 50 evaluable clinical patients receiving flap procedures at OSUMC for the clinical validation of the optimized protocol. No extrinsic MR contrast agent will be injected. Clinical patients' MRI images will be evaluated independently by radiologists and plastic surgeons and compared to the clinical CTA images.

The overall objective of this pilot study is to develop and optimize preoperative MRA imaging protocols for various perforators commonly used in flap surgery with phantoms and healthy volunteers and to obtain clinical validation of the optimized protocols with a group of patients receiving flap surgery at The OSU Wexmer Medical Center. Data obtained in this study may also serve as the basis for statistical planning of future clinical trials. Based on previous experience with other magnetic resonance imaging (MRI) techniques, the investigators hypothesize that optimal MRA images can only be obtained with a carefully selected combination of imaging hardware, acquisition, and postprocessing factors. The main objective of this pilot study is to determine this optimal combination through the comparison of image between different combinations. The secondary objective of this pilot study is to evaluate, both qualitatively and quantitatively, the quality of the optimized MRA images and compare them with clinical CTA images. The primary hypothesis is that the quality of the optimized MRA images is at least comparable to that of the CTA images. The quantitative measurements obtained from this pilot population will also serve as the preliminary data for future studies and be used in statistical calculations that determine their study population.

Eligibility Criteria:
Inclusion Criteria:

* greater than or equal to 18 years at time of enrollment
* able to provide informed consent
* able to lie in both prone and supine positions for at least 30 minutes
* the clinical patients need to have a flap procedure scheduled at the Ohio State University Medical Center within the next 24 months

Exclusion Criteria:

* Use of an IUD (intrauterine device) or medical patch
* Subjects with any type of activatable implants (e.g. cardiac pacemakers, deep brain stimulators, spinal cord stimulators, cochlear implants, electronic infusion pumps, etc.)
* Subjects with any type of metallic implants or foreign objects in torso region (e.g. cardiac stents, surgical clips, shrapnel fragments from war wounds, etc.)
* metal works and machinists (who may have metallic fragments in or near the eyes)
* severe auto accident victims
* subjects with permanent tattoos that may contain metallic coloring
* subjects with previous history of perforator flap surgery
* subjects who cannot communicate with the researcher for any reason
* claustrophobia
Multicenter Survey About Acute Uncomplicated Diverticulitis Management

Acute uncomplicated diverticulitis is a quite prevalent situation and consultation in the emergency department.

Its management has progresively changed towards a more conservative one and it is currently recommended in several guidelines the option of avoiding antibiotics in certain highly selected cases.

Nevertheless, the implantation of such recommendations in current clinical pratice is unknown and, hypothesizing it was still low, the reasons for such reluctancy are also unknown.

Both aspects can be considered quite interesting in order to design a specific plan in order to overcome such difficulties.

In order to do so, an online survery was designed and colorectal surgeons along Spain, based in the census of the Young Group from the Spanish Association of Colorectal Surgery were invited to participate. Invitations were distributed along usual communication channels of this group, such as email or chat mobile phone applications. All the responses to the survey will be analyzed in order to find out how many hospitals are using current managemente without antibiotics, its characteristics and, opposite, what are the main reasons for those hospitals that are not using it yet.


Eligibility Criteria:
Inclusion Criteria:

* Colorectal surgeons.
* Surgeons with emergency surgery activity.

Exclusion Criteria:

* Any other medical speciality.
Self-Management and Resourceful Transition of Type 2 Diabetes With Stage 3 Kidney Disease

The purpose of this study is to establish the usefulness and the impact of a tailored behavioral-education and counseling intervention titled Self-Management and Resourceful Transition (S.M.a.R.T) among patients with type 2 diabetes mellitus and stage 3 chronic kidney disease, in order to help them to manage their behaviors related to their condition and health.

The SMaRT intervention is a 3-week intervention that uses a combined behavioral-education and counseling methodology. The combined intervention involves computer-aided education alongside telephone counseling via motivational interviewing. The computer-aided education is tailored to the diagnoses of type 2 diabetes and chronic kidney disease and designed in a learning module approach to facilitate goal-setting and discussion of health concerns with greater efficacy and in a more informed way during the brief office visit. Such Computer-aided education has been used to improve diabetes self-management and glycemic control in middle-aged to older adults with moderate success. The inclusion of CKD information will augment current diabetes self-management intervention. The telephone counseling using the evidence-based behavioral change approach of motivational interviewing is a patient-centered approach of partnering with patients by eliciting their health-related concerns. This approach tailors the SMaRT intervention to include collaborative goal-setting with guidance based upon the patient's readiness for change.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed Type 2 Diabetes
* 18-85 years old
* Stage 3 Chronic Kidney Disease
* Speaks and reads English

Exclusion Criteria:

* Hypoglycemia with 3rd party treatment in past 3 months
* Type 1 Diabetes
* On Dialysis
* Does not speak English
* Factors likely to preclude protocol adherence
An Efficacy And Safety Study Of Tanezumab For The Treatment Of Pain Associated With Chronic Abacterial Prostatitis

The purpose of this study is to determine whether tanezumab is effective in the treatment of pain associated with chronic prostatitis.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of chronic prostatitis
* Male adults at least 18 years of age
* Moderate to severe chronic prostatitis, with an average pain score above a pre-defined level
* To use contraception.

Exclusion Criteria:

* History of symptoms for less than 3 of the last 6 months
* History of recurrent urinary tract infections, or genito-urinary cancer
* Use of finasteride or dutasteride within 6 months.
* History of hepatitis B, C or human immunodeficiency virus (HIV)
Interaction Between Host, Microenvironment and Immunity on Gastrointestinal Neoplasms

The primary objective: association study of characteristics of tumoral microenvironment and immunity of digestive cancers with patients' overall survival (OS).

The study aims to explore relationship between the molecular subgroups (DNA and RNA analysis), tumor microenvironment, host (immunity system, premetastatic niche, microbiota, metabolism) and survival (prognostic value), response (predictive value) and tolerance (toxicities) to conventional treatments or immunotherapies in digestive cancers, in particular, in colorectal cancer and pancreaticobiliary cancer.

This is a prognostic monocentric study which includes 2 parts:

* one retrospective observational cohort for which 150 eligible patients (who have being diagnosed between 1998 to 2020) will be entered in the cohort per year during 22 years targeting 3300 patients and
* one prospective interventional cohort in which 3000 patients (diagnosis will be done between 2020-2030) will be enrolled during 10 years. 10 years of follow-up for all patients. This cohort is non comparative, non randomized, non control.

The enrollment will last 10 years in Digestive Surgery Department, Ambroise Paré Hospital, APHP.

There is any change in management of patients' care who will participate to the study, all of the treatment modalities (i.e. surgery, chemotherapy, radiotherapy, immunotherapy, intra-arterial treatments and supportive care) are possible and choice of treatment will be made by investigator physician, after multidisciplinary meeting validation, and according to referential and recommendations of practice in department.

Statistic analysis

The statistic analysis will be performed and reported according to the international guidelines STROBE for the observational studies.

Eligibility Criteria:
Inclusion Criteria:

* Carcinoma of colorectal, pancreatic, biliary tract or gastro-oesophageal, or neuroendocrine digestive tumors with cytologically or histologically proven, regardless of the stage;
* Diagnosis between 1998 and 2030;
* Be \>/= 18 years;
* Have obtained signed informed consent (exemption for dead patients);
* Affiliated to the French social security - welfare system in France (CMU included).

Exclusion Criteria:

* Patient under tutoraship or curatorship;
* Foreign patient under AME schema, a medical help from the state in France;
* Pregnant or breastfeeding women (for prospective study);
* Any clinical, psychological or social reason which should influence patient compliance with protocol, according to investigator;
* Patient refusal.
Repeated Open Application Test (ROAT) Study With Hydroperoxides of Linalool

Linalool is currently one of the most used fragrance substances in cosmetic and household products. Previous studies report a high prevalence (5.9-11.7%) of contact allergy to hydroperoxides of linalool (Lin-OOH)1.0% in pet. among patch tested patients. The optimal test concentration of Lin-OOH in patch tests is not known and requires further investigation. It is of great importance to establish the optimal test concentration and elicitation threshold of Lin-OOH to improve diagnosis and prevent development of Allergic Contact Dermatitis (ACD).

We want to mimic real-life exposure to Lin-OOH, by conducting a ROAT (Repeated Open Application Test) study, on 40 adult participants (20 patients with confirmed contact allergy to Lin-OOH, and 20 healthy participants) to low doses of Lin-OOH using a simulated "perfume", during a maximum of 21 days of exposure.

With this knowledge, we aim to:

1. Establish the optimal patch test concentration to diagnose ACD to Lin-OOH
2. In case of confirmed contact allergy, examine the threshold value for the development of ACD upon daily exposure to a simulated leave-on cosmetic product


Eligibility Criteria:
Allergic participants:

1. Inclusion criteria

   * Positive (at least one reading) or doubtful patch test (at least two readings) result to hydroperoxides of Linalool within the last ten years
   * Aged 18 years or older
   * Received written and verbal information of the study
   * Signed written consent form
2. Exclusion criteria

   * Active eczema in test areas (volar forearms)
   * Pregnancy or breast feeding
   * Treatment with topical corticosteroids or other immune suppressants on/near test areas within two weeks prior to study start
   * Systemic immune-suppressant treatment within seven days prior to study start
   * UV exposure of test areas within three weeks prior to study start
   * Unable to cooperate or communicate with the investigators

Healthy controls:

1. Inclusion criteria

   * Aged 18 years or older
   * Received written and verbal information of the study
   * Signed written consent form
2. Exclusion criteria

   * Known or possible contact allergy to hydroperoxides of Linalool
   * Known contact allergy to other fragrance allergens
   * Active eczema or other known relevant skin diseases
   * Pregnancy or breast feeding
   * Treatment with topical corticosteroids or other immune suppressants on/near test areas within four weeks prior to study start.
   * Systemic immune-suppressant treatment within four weeks prior to study start.
   * UV exposure of test areas within three weeks prior to study start.
   * Participation in other clinical studies within four weeks prior to study start.
   * Unable to cooperate or communicate with the investigators.
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors

The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors. AYAs who were diagnosed with cancer and have completed cancer treatment will be recruited for this study. This study will enroll 20 participants in total and will last approximately 3 months.

This is a single-arm, prospective, interventional pilot study.

Adolescent and young adult (AYA) survivors of cancer ages 18-39 (n=20) will engage in three months of virtually group physical activity (PA) delivered via BurnAlong, a wellness platform and online app.

Participants will be asked to engage in a BurnAlong workout session with a partner (friend/spouse/child/fellow study participant) a minimum of three times a week for 3 months.

Participants will also meet monthly with an exercise physiologist for a customized exercise session. Participants are allowed to engage in additional PA and non-PA sessions on BurnAlong as desired.

Participants will also be asked to engage in a private social network discussions around key topics of interest for AYA communities with a focus on post-traumatic growth and positive psychology with a minimum of 2 post engagements a week for 3 months.

Participants will complete surveys and physical assessments at baseline and at end of study.

Participants also participate in a 1 hr qualitative exit interview about their well-being, participation experiences, and experience with using the BurnAlong platform.

Eligibility Criteria:
Inclusion Criteria:

* Cancer (all types) diagnosis between the ages of 15-39
* Between the ages of 18-39 during study participation
* At least 3 months post-active treatment completion
* Answers "no" to all questions on the Physical Activity Readiness Questionnaire
* Not currently meeting physical activity guidelines per leisure-time physical activity participation questionnaire
* Access to and ability to use a computer, tablet or phone device with internet access
* Ability to understand and read English
* Written informed consent obtained from subject and ability for subject to comply with the requirements of the study

Exclusion Criteria:

* Hearing loss or vision impairment that would preclude the participant from accessing and using the app (use of hearing aids or visual aids is acceptable) based on self-report
* Currently meeting physical activity guidelines (score of \>23 on Godin-Shephard Leisure-Time Physical Activity Questionnaire)
* Currently pregnant, based on self-report
* Patients with active treatment planned within the next 3 months. (Active treatment includes chemotherapy, biologic therapy, radiation therapy, surgery, and any combination.) Long-term hormonal/biologic treatments are acceptable except for AR-targeted therapies for prostate cancer. Participants with known metastatic disease, grade 3 or higher neuropathy, major surgery within 3 months of baseline visit, pregnancy of childbearing potential will be excluded.