cyrilzakka/clinical-trials huggingface dataset:
A Sustainable Choice to Reduce Carbon Footprint

This study aimed to evaluate the impact of carbon footprint education on breastfeeding practices among pregnant women.

This study aimed to evaluate the impact of carbon footprint education on breastfeeding practices among pregnant women.

In the sample size calculation performed using G\*Power 3.1.9.7 (Faul et al., 2007) software, the effect size value determined for the relationship between awareness levels regarding sustainable and healthy nutrition behaviors and reducing ecological footprint was determined as Cohen's r=0.470. Statistical power analysis was performed under A Priori: Compute required sample size (Correlation: Bivariate normal model), 95% power (1-β) and α=0.05 and in the light of these parameters, it was concluded that a sample size of at least 53 participants was required for the study in question. In case of data loss, it was envisaged to increase the sample by 20% as a result of statistical consultancy. Accordingly, it was planned to conduct the study with a total of n=64 people, n=32 in the intervention group and n=32 in the control group.

It was carried out with the participation of two groups. The carbon footprint education group received 4 education sessions of 60 minutes each. The control group received routine hospital care during this period, but no other intervention was made.

Data for the study were collected by the researcher using face-to-face interviews, a personal information form with demographic questions, and the measurement tools used in the study. The training was completed 4 weeks later. After the training, the measurement tools were used for the woman's postpartum period.

Participants were given an explanation of the carbon footprint education and told how, for how long, and where the education would take place. The carbon footprint education programme was completed by the participants in a specific way (nutrition, breastfeeding, environmental awareness) for each session. The education was delivered using a poster.

The carbon footprint education was given in 4 sessions in this way. The measurement tools were given to the participants again on the 1st day, 1st month, 3rd month and 6th month after birth.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women 24 weeks gestation
* Must be between 18 and 35 years of age.
* Women must provide informed consent to participate in the study, indicating their willingness to participate in the educational intervention and assessments.
* Attend educational sessions

Exclusion Criteria:

* Women with significant medical conditions that may affect breastfeeding or nutrition (e.g. serious mental illness, chronic disease) will be excluded.
* Multiple pregnancies
* Previous GREEN MOTHER training
* Substance abuse
* Women considered to be at high risk of non-compliance with the study protocol (e.g. those with unstable living conditions).
Bone Modeling Effects of Combined Anabolic/Antiresorptive Administration

The purpose of this study is to examine, via iliac crest bone biopsies, the mechanism of combined teriparatide and denosumab on the bone of postmenopausal osteoporotic women after 3 months of treatment.


Eligibility Criteria:
Inclusion Criteria:

* women aged 45+
* postmenopausal
* osteoporotic with high risk of fracture

Exclusion Criteria:

* significant previous use of bone health modifying treatments
* known congenital or acquired bone disease other than osteoporosis
* significant renal disease, liver disease, cardiopulmonary disease, or psychiatric disease
* abnormal calcium or parathyroid hormone level
* serum vitamin D \<20 ng/mL or \>60ng/mL
* serum alkaline phosphatase above upper normal limit with no explanation
* anemia (hematocrit \<32%)
* history of malignancy (except non-melanoma skin carcinoma), radiation therapy, or gouty arthritis
* history of urolithiasis within the last one year
* excessive alcohol use or substance abuse
* use of oral or parenteral glucocorticoids for more than 14 days within the past 6 months
* extensive dental work involving extraction or dental implant within the past or upcoming 2 months
* known sensitivity to mammalian cell-derived drug products
* known contraindications to denosumab, teriparatide, or any of their excipients
* known contraindications to tetracycline, demeclocycline, or other antibiotics in this drug class
* continuous use of tetracycline for \>1-month duration within the last 10 years
Stent Versus Conservative Treatment in Patients With Deep Venous Obstruction

Patients will be randomised between deep venous stenting or conservative management


Eligibility Criteria:
Inclusion Criteria:

* Age \>18 years
* Meet criteria for PTS or
* Patients with May Thurner syndrome on additional imaging
* Life expectancy of more than one year
* Deep venous thrombosis \> 1 year
* Signed informed consent

Exclusion Criteria:

* Previous intervention of central veins (inferior vena cava, iliac veins, common femoral vein) on the affected limb
* Known pregnancy
* Inability to answer Dutch QoL questionnaires or limited communication in Dutch (written and spoken)
* Contra-indication for prolonged anticoagulant treatment
* Recent, \<1 year, deep venous thrombosis or pulmonary Embolism
* Known contrast allergy
* Known dialysis or renal insufficiency needing additional preparation for injection of contrast
Treatment of Panic Disorder Among Individuals Consulting Emergency Departments for Non Cardiac Chest Pain

The purpose of this study is to assess the impact of three different treatment modalities on panic symptoms, quality of life and use of health services among individuals consulting an emergency department for non cardiac chest pain and having Panic Disorder.


Eligibility Criteria:
Inclusion Criteria:

* Aged 18 and over
* Mastered oral and written French
* Consulted an emergency department for chest pain with very low risk of coronary disease (normal ECG and blood tests)
* Met criteria for Panic Disorder

Exclusion Criteria:

* Chest pain with an obvious medical origin (obvious trauma or abnormal pulmonary x-rays)
* Had received cognitive-behavior therapy for Panic Disorder in the last six months
* Cognitive impairment preventing the completion of psychological assessment
* Past or present psychotic episode, Bipolar Disorder, or organic mental disorder
* Current Abuse or Dependence Disorder
* If another Mental Disorder is present, its severity was equal or inferior to the severity of Panic Disorder
* Current medical condition preventing the participant from receiving pharmacological of cognitive-behavior treatment
The Newly Reported (0-90°) Versus (0-30°) Biplanar Fluoroscopic Puncture Technique in PCNL

To analyze and compare the puncture success rate, puncture fluoroscopy time and intraoperative puncture complications of two different puncture techniques; fluoroscopic bi-planar (0-30º) versus newly reported bi-planar (0-90º) technique in PCNL.

Nephrolithiasis is one of the most common urological diseases, it is a widespread and challenging issue for both patients and healthcare systems. It is responsible for a significant financial and psychological burden, with an increased incidence of disease. The EAU (European Association of Urology) Guidelines recommend percutaneous nephrolithotomy in patients with kidney stones \>2 cm.

The most crucial step of the procedure is the precise puncture of the caliceal system. This can be accomplished by the use of fluoroscopy, ultrasound, or the combination of both and new other imaging modalities techniques. Among them, Fluoroscopy is the most common method for conducting the percutaneous puncture by urologists worldwide using multiple mono-planar or bi-planar fluoroscopic techniques.

However, all fluoroscopic approaches face the same limitation, which is the difficult interpretation of the three-dimensional renal anatomy based on the two-dimensional X-ray information. Another disadvantage is the amount of fluoroscopic radiation used. Surgeons, assistants, nurses and patients, however, all have to accept various levels of radiation exposure. Numerous researches have revealed that it is still harmful to the human body who is exposed to radiation frequently, although under the aegis of protective aprons and thyroid shields, thus the application is affected to varying degrees.

Fluoroscopic bi-planar techniques provide better information about the depth and direction of the collecting system than mono-planar methods. The most popular bi-planar methods described in the literature are the triangulation (0-30º), the "bull´s eye" technique and the less known bi-planar technique (The 0-90º technique) described by Dr. Paul Escovar. A newly published (0-90º) technique by Braulio O Manzo et al to increase the accuracy of calculating the needle path to the exact calyx depth and decreases its radiation exposure.

In the current study, the investigator aimed to compare two different renal access techniques; fluoroscopic 0-30 and modified 0-90 technique regarding success rate, fluoroscopy time and intraoperative puncture complications.

Eligibility Criteria:
Inclusion Criteria:

* A patient over 18 years old.
* Renal stone 2 cm or greater.

Exclusion Criteria:

* A patient \< 18 years old.
* Congenital anomalies of the kidney: horseshoe kidney, malrotated kidney, pelvic ectopic kidney.
* Patient with obvious spinal deformity.
* Coagulopathies.
Pilot Study of Sodium Bicarbonate in Generally Healthy People With Low Bicarbonate

The goal of this pilot study is to determine whether oral sodium bicarbonate can raise low serum bicarbonate concentration in people without chronic kidney disease (CKD). Participants will take sodium bicarbonate for six weeks, followed by a four week washout period.

CKD affects 25 million Americans and the risks of cardiovascular morbidity, hospitalizations, and death are substantially higher for people with CKD. Furthermore, 6% of the total Medicare budget is spent on 600,000 people with end-stage renal disease. Thus, CKD is highly prevalent, associates with poor outcomes, and is a tremendous financial burden to society.

Apart from treating hypertension and diabetes, there are no therapies that prevent CKD. However, results from two studies have found that low serum bicarbonate levels increase risk of developing CKD, which suggests that normalizing low serum bicarbonate may prevent CKD.

One way to raise low serum bicarbonate is by taking sodium bicarbonate. Whether sodium bicarbonate, which is commonly prescribed to raise low serum bicarbonate in people with CKD, can raise low bicarbonate in people without CKD is uncertain because the reason bicarbonate is low in people without CKD is unclear. This is because low bicarbonate by itself cannot distinguish whether the acid-base abnormality is primary metabolic acidosis or respiratory alkalosis. The former process is readily corrected with alkali. However, the administration of alkali in the latter situation may not raise bicarbonate concentration.

Therefore, the purpose of this pilot study is to determine whether oral sodium bicarbonate can raise low serum bicarbonate in people without renal disease.

The study is a single-arm open label study of 15 individuals without CKD with low serum bicarbonate concentration. The study duration is 10 weeks. After completing the baseline visit, participants will take oral sodium bicarbonate (initial dose level: 0.3 milliequivalents per kilogram per day (mEq/kg/d) for 6 weeks (On-treatment period), followed by a 4 week Off-treatment period. Serum concentrations of sodium bicarbonate will be tested during the treatment period, at the end of the On-treatment period (Week 6) and at the end of the Off-treatment period (Week 10).

Eligibility Criteria:
Inclusion Criteria:

* Estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73m2
* Urinary albumin/creatinine ratio \< 30 mg/gm
* Serum bicarbonate ≤ 23 mEq/L (average of the two most recent measurements within the past year)
* Age ≥ 50 years

Exclusion Criteria:

* Blood pressure ≥ 160/100 mm Hg
* Serum potassium \< 3.5 mEq/L
* New York Heart Association Class 3 or 4 heart failure symptoms
* Chronic oxygen therapy
* Chronic obstructive pulmonary disease requiring daily bronchodilator or prednisone therapy
* Weight ≥ 160 kg
* Use of sodium bicarbonate, sodium citrate, potassium citrate, or potassium bicarbonate within the previous two weeks.
Effect of Mindfulness Training on Sleep and Inflammation Among Older Adults With Sleep Problems

The primary aim of the study is to test the effect of mindfulness training on sleep parameters among older adults with insomnia symptoms

The secondary aims are to examine if changes in mindfulness meditation practice (daily log) and level of mindfulness (self-report) are associated with changes in sleep parameters, and to determine if mindfulness training is associated with in vitro biological markers of peripheral inflammation


Eligibility Criteria:
Inclusion Criteria:

* Men and women (all races and ethnicities) 55 years of age and older
* Have current problems sleeping
* Fluent in English
* Able to understand and provide signed informed consent
* Willing to be randomly assigned to treatment condition

Exclusion Criteria:

* Individuals currently undergoing major medical treatment such as surgery, radiation, or immunotherapy
* Individuals living outside of a 20 mile radius from the UCLA Medical Center
* Individuals with current substance dependence
Online Dance Versus Therapeutic Exercise for Parkinson Disease.

This is a randomized clinical trial in an online format, which will only include people with PD randomly divided into two groups:

Group 1 - Social Telerehabilitation with Dance and Music Group 2 - Social Telerehabilitation with Multimodal Therapeutic Exercise and Music


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of idiopathic PD according to the clinical criteria of the London Brain Bank Criteria (2006);
* Age between 40-90 years;
* A minimum score of 18 in the Montreal Cognitive Assessment;
* Drug therapy/exercise stable for at least four weeks before the study starts;
* Agreement to participate in the study according to the Informed Consent Form.

Exclusion Criteria:

* Auditory and/or visual disturbances that compromise understanding simple commands;
* Access to the internet and a device to access online classes;
* A house member and/or caregiver at home for supervision during the entire experiment, including evaluations and interventions. For patients scoring less than 2.5 points on the modified Hoehn and Yahr Scale (indicating mild disease impairment, independence in daily living activities, and no risk of falls), the requirement for household member supervision may be waived.
Patient Generated Goals in Mental Health: Better Outcomes?

Researchers believe that clinical care can be improved by engaging patients and families directly in planning the care process. Engagement efforts have included asking patients/families to provide information about whether they are getting better. But what does "getting better" mean? The merits of surveys, questionnaires, or rating scales have been widely discussed. Should they be disorder-specific or global? What should the investigators do if patients have difficulty reading or understanding these instruments? Investigators in the United Kingdom have proposed a simple solution: ask the patients and families what their primary goal treatment goal is and track progress together on that goal (Goal-Based Outcomes or GBO). Although there has been some work to suggest that this is helpful, it has never been tested in a controlled way. This study will do a randomized controlled trial to test whether GBO improves clinical care in child and youth mental health. Although the study will use this in child and youth mental health care, if it is successful, it can be tested and applied in any care setting with any type of medical problem. This could change practice at the Children's Hospital of Eastern Ontario (CHEO) and throughout Canada.


Eligibility Criteria:
Inclusion Criteria:

* Children and youth
* Attending outpatient mental health services at CHEO

Exclusion Criteria:

-Child and youth attending group therapy at CHEO Outpatient Mental Health Services
Aspirin Thromboprophylaxis After First-line Total Hip and Knee Replacement

Annually, more than 100,000 total hip prostheses (THA) and more than 100,000 total knee prostheses (TKA) are implanted for osteoarthritis in France, and these figures are set to increase significantly in the future as in all industrialized countries. . Venous thrombosis is a potentially serious complication after PTH and PTG, justifying various prophylactic measures. In France, aggressive prophylaxis with low molecular weight heparin (LMWH) or direct oral anticoagulants (DOA) was until recently recommended, because this drug is considered to be the most effective, at the cost of a bleeding risk implicitly assumed but often poorly. evaluated. A recent publication suggests that the risk of bleeding is currently greater than the risk of a thromboembolic event.

More recently, foreign or international recommendations have broadened the range of these recommendations, notably by introducing aspirin as a possible prophylactic agent. While this molecule is potentially less effective than LMWHs or ADOs, it could decrease the risk of iatrogenic hemorrhage. The introduction of enhanced recovery procedures after surgery (RAAC) could decrease the risk of thrombosis without modifying the risk of bleeding, and thereby improve the cost-benefit ratio of aspirin, justifying its recent inclusion in the current French recommendations when The operated follows such a protocol.


Eligibility Criteria:
Inclusion criteria:

* Adult patient (≥ 18 years old);
* Patient operated on for a first-line total hip or knee replacement by the principal investigator;
* Patient not having expressed his opposition, after information, to the reuse of his data for the purposes of this research.

Exclusion criteria:

- Subject having expressed opposition to participating in the study
A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF)

The goal of this clinical trial is to compare protein supplements in patients with kidney failure on dialysis. The main questions it aims to answer are:

* To determine whether the supplementation of egg white protein pudding in a population of individuals with kidney failure on dialysis is feasible.
* To determine whether egg white protein pudding supplementation improves serum albumin similar to other standard nutritional supplements.
* To determine the effects of the egg white protein pudding on frailty measures, dietary intakes and analytes in the blood and urine. Participants will receive either the egg white pudding (experimental) or control (Ensure plus) at the end of their dialysis treatments 3-days per week for 12 weeks.


Eligibility Criteria:
Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the trial
* Male or female aged ≥18 years with CKD
* On chronic in-center hemodialysis for \> 3 months
* Serum albumin \<35 g/L
* No expected change in dialysis modality or relocation outside of Winnipeg during the intervention period (12 weeks)

Exclusion Criteria:

* Allergy to eggs
* History of renal transplant
* Serum albumin ≥ 35 g/L
* Bowel diseases
* Cancer
* Pregnancy
* Receiving chemotherapy treatment
* Inability to consume treatment product
* Allergy to study treatment ingredients
* Planning on starting an exercise program during the duration of the trial
* Inability to obtain written informed consent
Elderly Cancer PatIents, Safety and qualiTy of Life Under immunOtheraPies

The co-primary objectives will be to assess the safety and quality of life under treatment.

The co-primary objectives will be to assess the safety and quality of life under treatment. Secondary objectives will be evaluations of geriatric data modifications under treatment, efficacy (progression-free survival and overall survival), correlation between toxicity and efficacy, and comparison of the safety profiles between various immunotherapy regimens.

Another secondary objective will be the comparison between patients and clinicians symptom reporting. The investigators will also perform a pharmacokinetics analysis on PD1-monoclonal antibodies to improve the understanding of PD-1 inhibitors pharmacokinetics for the elderly population.

Finally, toxicity and efficacy will be compared to immunological parameters such as the description of tumor infiltrating lymphocytes, markers of immunosenescence and inflammation.

Eligibility Criteria:
Inclusion Criteria:

* Patients eligible to start a treatment including immune checkpoint inhibitors (Nivolumab, Ipilimumab, Pembrolizumab, and so on...)
* Diagnosis of advanced or metastatic melanoma or NSCLC (All treatment lines will be allowed)
* Age ≥ 70 years
* Having personally signed and dated informed consent
* Patient affiliated to the ''National security'' regimen or beneficiary of this regimen

Exclusion Criteria:

* Immune checkpoint inhibitor therapy initiated before study enrolment
* Concomitant participation in other investigational clinical trials involving an immune checkpoint inhibitor
* Immune checkpoint inhibitor treatment in a context of other solid tumours
* Immune checkpoint inhibitor treatment in a context of haematological malignancies
* Being unable or unwilling to comply with the requirements of the protocol, as assessed by the investigator
* Patient in urgency situation, adult under legal protection, or unable to give his consent
Outcomes of Mechanically Ventilated Patients With Low Serum Testosterone

This is a study to determine the testosterone serum levels in male patient with acute respiratory failure requiring mechanical ventilation. The objective is to determine if low levels exist in this population and if it correlates with length of mechanical ventilation.

Hypothesis: Serum testosterone levels in mechanically ventilated male patients are significantly decreased from normal levels and correlate with disease severity and outcomes.

Study Objectives

1. To confirm and quantify the presence of hypotestosteronemia in critically ill male patients with acute respiratory failure requiring mechanical ventilation via endotracheal intubation.
2. To correlate serum testosterone levels with disease severity, short-term outcomes, and survival in mechanically ventilated male patients.
3. To determine if demographic patient characteristics, such as age, admitting diagnosis, or the presence of co-morbidities, affect serum testosterone levels during mechanical ventilation.

Eligibility Criteria:
Inclusion Criteria:

1. Male
2. Age \> 18
3. Admission diagnosis of acute respiratory failure requiring endotracheal intubation and mechanical ventilation for \> 24 hours
4. APACHE II score \> 15 (APACHE: Acute Physiology and Chronic Health Evaluation - general indicator of disease severity and outcomes predictor)

Exclusion Criteria:

1. Chronic mechanical ventilation (i.e. patients on mechanical ventilatory support for \> 21 days for at least 6 hours per day)
2. Patients on mechanical ventilation for \> 48 hours prior to MICU admission
3. Non-invasive mechanical ventilation
4. Patients intubated and mechanically ventilated for drug overdose and anticipated to be intubated for \< 24 hours
5. Known diagnosis of hypogonadism (requiring testosterone hormonal supplementation) or currently receiving testosterone therapy or received testosterone therapy within 30 days of MICU admission
6. History of testicular, prostate or pituitary tumor
7. Chronic use of systemic steroids prior to admission
8. Terminally ill patients who are not expected to live longer that 3 months