cyrilzakka/clinical-trials huggingface dataset:
Compare the Aesthetic Effect of Different Thyroidectomies

One hundred twenty female patients who underwent thyroidectomy were evenly distributed into three groups: conventional access (CA), aesthetic principles access (APA) and minimally invasive access (MIA). The Patient and Observer Scar Assessment Scale (POSAS) was used as the assessment tool for the linear scar. After one year follow-up, the cosmetic outcomes were assessed.

A prospective study in patients with DTC at the Department of Head and Neck Surgery at Perking University Cancer Hospital (also called Beijing Cancer hospital). A total of 120 female patients who underwent surgical treatment for DTC were enrolled in the study from June 2012 to June 2014. All patients were diagnosed with DTC through preoperative fine needle aspiration biopsy pathology. These patients were individually randomly assigned (1:1:1 ratio) into the conventional access group (CA), the aesthetic principles access group (APA) or the minimally invasive access group (MIA). Lobectomy plus ipsilateral central lymph node dissection (CLND) was adopted in each patient. DTC staging was T1N0M0 or T1N1M0. The investigators retrieved the patients' information, including age, incision length, incision closure procedure, incidence of complications, and cosmetic assessment from patients' medical records. Patients with other medical diseases, such as diabetes or obesity, a smoking history, a keloid tendency, a history of radiotherapy to the head and neck, or with incomplete information, were excluded. RLN function was evaluated by electronic fiber laryngoscopy 6 months postoperatively. The follow-up time was 12.3 months. The research was reviewed and approved by the Ethics Committee of Peking University Cancer Hospital, and informed consent was obtained from all patients to publish the information/image(s) in an online open-access publication. The study was open-label with no blinding of patients, clinicians, or research staff.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with DTC through preoperative fine needle aspiration biopsy pathology.
* DTC staging was T1N0M0 or T1N1M0.
* Female
* Age over 18 years
* Subjects who fully understand the study process, participate voluntarily

Exclusion Criteria:

* Patients with other medical diseases, such as diabetes or obesity, a smoking history, a keloid tendency, a history of radiotherapy to the head and neck, or with incomplete information.
How to Predict Post-Surgical Bleeding and Hemoglobin in Liposuction?

To evaluate the effect of using a mathematical model developed through pre- and post-surgical hemoglobins to predict the volume to aspirate in patients undergoing primary body liposuction.

Postoperative anemia is a significant risk associated with liposuction, yet the scientific literature lacks detailed data on blood loss relative to the volume of fat removed. To address this, the investigators aimed to develop a mathematical formula predicting the decrease in postoperative hemoglobin (Hb post) based on preoperative hemoglobin (Hb pre), Body Mass Index (BMI), and the volume of fat suctioned. An observational, analytical, non-experimental, prospective study was conducted on liposuction patients to validate this predictive formula. Statistical analysis using Spearman's test showed that the results were statistically significant (P \< 0.05).

Eligibility Criteria:
Inclusion Criteria:

* Patients of indistinct gender, operated on at the Centro Médico Nacional de Occidente for primary liposuction.
* Age between 18 to 60 years old
* Liposuction technique used: Super wet or Tumescent.
* Surgical procedure on any area of the body
* Large volume liposuction (\> 5 L)
* Use of regional anesthesia

Exclusion Criteria:

* Presence of any of the following comorbidities: Systemic Arterial Hypertension or Diabetes Mellitus type 2.
* Performance of 2 or more procedures
* Use of medications (NSAIDs and/or coadjuvants that modify coagulation times).
Study of DNA Samples From Patients With Multiple Myeloma

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

PURPOSE: This laboratory study is looking at DNA samples from patients with multiple myeloma.

OBJECTIVES:

* Determine whether there is an increased frequency of 1 or more polymorphic alleles that are associated with clinical endpoints using custom myeloma single nucleotide polymorphism (SNP) chip analysis of banked DNA samples from patients with multiple myeloma.
* Determine SNPs associated with toxicities caused, not by variations in tumor cell genetics, but by individual genetic variations affecting drug activation, distribution, metabolism, and export (ADME).
* Determine SNPs associated with response, influenced by the same ADME.
* Determine SNPs associated with bone disease (as a variable) among patients with multiple myeloma.
* Determine SNPs associated with epidemiology (i.e., risk factors for the development of multiple myeloma).

OUTLINE: This is a retrospective, multicenter study.

Banked DNA samples are analyzed using a custom single nucleotide polymorphism (SNP) chip to assess approximately 3,590 SNPs from 1,061 genes that are associated with myeloma growth and response.

PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Diagnosis of multiple myeloma
* DNA samples banked from other ECOG studies (and other clinical trial groups \[e.g., SWOG and MRC\])

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified
Efficacy Parecoxib and Ketorolac as Preemptive Analgesia in Spine Fusion

The purpose of this study is to evaluate the efficacy of Parecoxib and Ketorolac as a preemptive analgesia in patients undergoing lumbar spinal fusion.

A prospective, double-blinded randomized control trial. Randomly allocated patient undergoing posterior lumbar spinal fusion into 3 groups (n=32) to receive Parecoxib, Ketorolac and Placebo around 30 minutes prior to incised skin. Efficacy was assessed by visual analog scale score (0-10), total opioid consumption, complication and bleeding also recorded.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing lumbar spinal fusion for one to three levels
* ASA class I or II

Exclusion Criteria:

* History of allergy to Sulfa group
* History of allergy to OPOID or NSAIDs
* Contraindicate to NSAIDs use
* History of coagulopathy or platelet disfunction
Bariatric Surgery Registry

Periodic analyses of our extensive database with regards to different surgical procedures for severe obesity and different obesity co-morbidities will be of benefit to our severely obese patients as well as to others world-wide.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of morbid obesity
* Have undergone a bariatric surgical procedure at the VCU Medical Center
Effectiveness of Brief Mindfulness-Based Interventions for Painful Temporomandibular Disorders Among University Students

The goal of this clinical trial is to learn if brief mindfulness-based intervention (BMBI) is beneficial to participants suffering from painful temporomandibular disorders (TMD). The objectives of the research are:

1. To compare physical functioning (pain intensity and jaw function) in UM students with chronic pain-related TMD before and after receiving BMBI
2. To compare psychological distress and mindfulness state in UM students with chronic pain-related TMD before and after receiving BMBI
3. To compare the quality of life of UM students with chronic pain-related TMD before and after receiving BMBI
4. To compare the changes in physical functioning, psychological distress, mindfulness state and quality of life between UM students in the intervention (BMBI) and the control groups.

Participants will:

Listen to the audio recordings 3 times a week, for 3 months when they are about to sleep.

Make 4 visits to the clinic: Baseline, 2 weeks, 1 month and 3 months later.


Eligibility Criteria:
Inclusion Criteria:

* Students attending Universiti Malaya
* Able to read and understand English.
* Willing and able to give informed consent.
* Score 3 and above on the TMD-PS, for at least 3 months.

Exclusion Criteria:

* Hearing impairment.
* Currently on psychiatric follow up and/or taking psychotropic prescriptions (antidepressants, anti-anxiety medications, stimulants, antipsychotics, and mood stabilizers).
* Experience with activities similar to the intervention such as meditation, yoga or tai chi.
* Currently practicing some form of mindfulness meditation.
* History of orofacial trauma, craniofacial pathology, and previous orofacial surgeries (including orthognathic and TMJ)
* Systemic rheumatic, neurologic/neuropathic, endocrine (e.g., diabetes mellitus) or immune / autoimmune diseases or widespread pain or being treated with immunosuppressant drugs
* Non-TMD orofacial pain disorders
* Radiation treatment to head and neck.
* Use of narcotic pain medication, muscle relaxants or steroid therapy unless discontinued 1 week before enrolment to study
* Use of nonsteroidal anti-inflammatory medications unless the medication(s) were discontinued for 3 days prior to enrolment (use of acetaminophen is allowed as a rescue drug)
* Currently on antibiotics or taken antibiotics within the last 2 weeks prior to start of study
* Currently pregnant or lactating women
Project Fluido: Fluid Watchers

The long-term goal of this research is to determine whether a psychoeducational intervention will support self-care behaviors in Hispanic patients with heart failure. The specific goal of this study is to determine whether a culturally-appropriate psychoeducational intervention in Hispanic patients with heart failure, compared to a control group, will improve heart failure knowledge and self-care behaviors.

We hypothesize that patients who receive the intervention will have improved heart failure self-care behaviors and depression scores as measured by the Self-Care Heart Failure Index and Patient Health Questionnaire.

A randomized clinical trial research design is planned. Investigators will obtain baseline and final measures on the intervention and control groups. A sample of 60 adult Hispanic heart failure patients will be recruited. Each patient will either participate in the psychoeducational intervention or usual care. A repeated measures (longitudinal) analysis will be used to examine these aims by employing a linear mixed models approach. The basic analysis has one between subjects (fixed) factor, group, with 2 levels (education and control) and one repeated factor, time, with 2 levels (baseline and 12 months). This analysis allows for testing the main effect of group, main effect of time, and the group by time interaction. The potential benefit of improving heart failure knowledge and self-care in Hispanic heart failure patients is that these patients may better understand how to care for themselves. This study will provide data to examine the longer-term outcomes of emergency department visits and hospitalization events in Hispanic patients.

Eligibility Criteria:
Inclusion Criteria:

* have been hospitalized for heart failure within the previous 24 months
* identify themselves as Hispanic in origin
* speak and write in Spanish or English

Exclusion Criteria:

* live in a nursing home or institution,
* age less than 18
* cognitive deficits
* serious life-limiting co-morbidity such as active cancer
Evaluation of OCT and Visual Field Changes After Vitrectomy and ILM Peeling

To evulate changes in VF and OCT after viterctomy associated with ILM peeling.

Macular epiretinal membrane (ERM) is a disorder of the vitreomacular interface characterized by ﬁbrocellular proliferation on the anterior surface of the internal limiting membrane (ILM) of the macula. Pars plana vitrectomy with ERM removal and inner limiting membrane peeling is the standard surgical treatment for an ERM. ILM peeling is performed to eliminate the scaffold for myoﬁbroblast proliferation and any microscopic ERM in order to prevent ERM recurrence. ILM peeling is indicated for other pathologies other than ERM such as, diabetic macular edema, and macular hole. ILM peeling is a traumatic procedure that may have many effects on the underlying inner retinal layers that may lead to changes in retinal function.

Retinal edema, eccentric scotoma, dissociation of the nerve fiber layer, iatrogenic punctuate chorioretinopathy, and subretinal, retinal, and vitreous hemorrhage are well described secondary to the surgical trauma of peeling in addition to stain toxicity. Investigation of these changes may assist in aiding the development of minimally traumatic techniques for ILM removal .

Evaluation of functional changes may include visual field and Multifocal electroretinography assessment. Visual field defect after vitrectomy a well known post operative complication usually in eyes that underwent fluid air exchange, the cause of visual field defect remain unclear.

Optical Coherence Tomography (OCT), imaging is done to evaluate inner retinal layers after ILM peeling,High myopic eyes might develop more severe, "scattered" inner retinal defects after ILM peeling.

Eligibility Criteria:
Inclusion Criteria:

1. 1-Idiopathic ERM,
2. Primary full thickness macular hole,
3. Lamellar macular hole, and
4. Vitromacular traction.

Exclusion Criteria:

* 1-Patients with a secondary ERM,

  1. diabetic retinopathy,
  2. venous occlusion,
  3. retinal detachment,
  4. uveitis, and
  5. trauma. 2-Other ocular pathologies that could interfere with the functional results

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  1. dense cataract ,
  2. glaucoma, and
  3. previous retinal surgery.
Risk Factors for Distal Caries of Second Molars Adjacent to Mandibular Impacted Third Molars

Distal surfaces of second molars adjacent to wisdom teeth are always at risk for caries and external root resorption. The incidence of caries is high, especially in partially impacted third molars in mesioangular and horizontal positions. In this study, investigators aimed to examine the caries correlation in the distal second molar with the age, gender, side and DMFT scores of the participants.


Eligibility Criteria:
Inclusion Criteria:

* being between 20 and 40 years old
* having a surgery appointment for removal of the partially impacted third molar which is mesioangular or horizontal position
* having an orthopantomogram on the database
* and having a second molar adjacent to the impacted third molar

Exclusion Criteria:

* crowned or restored the second molar
* any surgery related to the contact area
* any pathology related to the second or third molar
* a radiological artifact on the contact area
* insufficient radiological quality for the evaluation.
Prevention of Seasonal Affective Disorder

A Placebo Controlled Study Evaluating The Effectivess Of Medication In Preventing Seasonal Affective Disorder


Eligibility Criteria:
Inclusion Criteria: (Patient must meet these criteria in order to be eligible for this study.)

* Patient has a history of Major Depressive Disorder (MDD) with a seasonal pattern.

Exclusion Criteria: (Patient cannot meet these criteria in order to be eligible for this study.)

* Patient has a current or past history of seizure disorder or brain injury.
* Patient has a history or current diagnosis of anorexia nervousa or bulimia.
* Patient has recurrent summer depression more frequently than winter depression.
* Patient has primary diagnosis of panic disorder, Obsessive Compulsive Disorder (OCD), Posttraumatic Stress Disorder (PTSD), acute distress disorder, bipolar II disorder or other psychotic disorders.
* Patient has initiated psychotherapy within the last 3 months.
One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy

Le Fort I osteotomy is often used in orthognathic surgery for patients to solve midface retrusion. It is known that post-surgical stability of Le Fort I osteotomy can be influenced by single jaw or bimaxillary procedures, fixation techniques or interpositional grafting. In patients with cleft lip and palate, the postoperative instability of Le Fort I osteotomy can be even worse due to scar tissue resulted from palate surgery. Segmental LeFort I osteotomy is another useful surgical modifications that can be easily done through the alveolar cleft. It is performed to allow the correction of differences in the occlusal planes, correction of transverse discrepancy or to facilitate an optimal occlusion. The most important benefits is that the alveolar cleft in patients who have not had alveolar bone graft surgery or failed to have successful result can be narrow down or even closed by approximation of two separating alveolar segments. However, there are limited previous studies comparing the stability of segmental versus one-piece Le Fort I osteotomy especially in patients with cleft. It is our aim to investigate whether one-piece Le Fort I osteotomy or segmental Le Fort I osteotomy can provide a better stability after surgery.

Measurements Skeletal movement

1. Skeletal Surgical movement from T2 to T1

   * positional change of landmarks in vertical from constructed Frankfurt plane
   * positional change of landmarks in horizontal plane in relative to constructed coronal plane through Sella point
2. Post-Surgical skeletal movement (Stability) from T3 to T2

   * positional change of landmarks in vertical from constructed Frankfurt plane
   * positional change of landmarks in horizontal plane in relative to constructed coronal plane through Sella point
3. Skeletal angular measurement change on mid-sagittal plane from (T2 to T1) and (T3 to T2)
4. Dental change measured from digital maxillary cast in transverse direction from (T2 to T1) and (T3 to T2)
5. Facial Height / Facial Proportion changes from (T2 to T1) and (T3 to T2)
6. Alveolar cleft width changes from (T2 to T1) and (T3 to T2)

Eligibility Criteria:
Inclusion Criteria:

1. Cleft lip/palate patients
2. Non growing Taiwanese adults, at least 18 years old for men and 16 years old for women
3. Patients with midface retrusion and malocclusion that will need Le Fort I osteotomy
4. Rigid fixation with bone plates
5. Patients who signs the informed consent form

Exclusion Criteria:

1. Association with craniofacial anomalies
2. Patient without complete 3D imaging records including CBCT scans and digital dental models
Vital Signs Camera Study

This study is a single center, prospective clinical investigation which is balanced for gender, age, Body Mass Index (BMI) and skin color. Simultaneous measurements of PR and RR on study participants will be collected in conditions described in IFU and various suboptimal conditions. The study participants will be recorded with the VSC demo app (together with a compatible camera and computing hardware) and reference devices. PR and RR data to be collected by the VSC demo app, will be post-processed after the clinical investigation and compared with the reference devices. Persons who are willing to participate will be asked to provide their consent.

Primary objective:

• To assess the clinical safety and effectiveness of Pulse Rate (PR) and Respiration Rate (RR) measured with the VSC-MEDlib within the intended use compared to the gold-standard reference devices.

Exploratory objective:

• To assess the clinical safety and effectiveness of Pulse Rate and Respiration Rate measured with the VSC-MEDlib during suboptimal circumstances (outside the scope of the intended use), compared to the gold-standard reference devices.


Eligibility Criteria:
Inclusion Criteria:

* Persons with ASA I or II classification
* Adult population (age \>18 years old)
* BMI ≥ 18 - ≤ 40 kg/m2
* Able to intensively exercise for 10 minutes
* Persons willing to give informed consent
* Willingness to have vital signs measured by a medical mobile application
* Willingness to follow study protocol (e.g., put on sunglasses, facial make-up, medical face-mask and sitting still up to 2 minutes)

Exclusion Criteria:

* Vulnerable populations (e.g., age \<18 years old, not able to consent by themselves, or immunecompromised or pregnant women)
* Cardiac arrhythmias (e.g., Atrial Fibrillation, Supraventricular Tachycardia, Ventricular arrhythmia, regular ectopic beats)
* Persons present signs of infection
* Participant has known allergic reactions to make-up and/or make-up remover
* Persons with positive COVID 19 test in last 14 days
* Participant who exhibit irregular or excessive movement such as tremors, tics, shaking and/or shivering
* Participant is Philips employee or their family members residing with this Philips employee.
Functional Magnetic Resonance Imaging (fMRI) for the Study of Response Inhibition, and Face and Linguistic Processing in Autism

This study investigates face processing, response inhibition and phoneme processing in autistic adults by fMRI.

Fifteen adult outpatients with high functioning autism or Asperger's Syndrome will be recruited. Fifteen healthy volunteers matched for age and IQ will also be recruited. Participants will undergo an fMRI scan. During the scan they will perform a task. The paradigm is designed to test control inhibition, face processing and language. Therefore, it includes a go-no go test, a face emotion discrimination test and a linguistic sound. The subjects are shown a series of faces with happy or sad expressions in random order. Each face presentation is accompanied by either a standard or variant sound. The sound stimulus is the English phoneme /oe/. The variant sound was created by raising the frequency of the standard sound by 20%. The task consists of four blocks. During each block the subjects are asked to press a button when they see a happy or sad face depending on the block. Each block consists of 96 trials lasting 2 seconds and an initial and final fixation period of 40 sec. For each trial the target image is projected for 500 ms. There is 1250 ms fixation time allowed for response and 250 ms for jitter. Twenty-four of the 96 trials are no go trials and 16/96 are sound oddball trials. The oddball is at least two trials apart (between two variant sounds there are at least two standard sounds). There are 24 faces displayed in total, 12 female and 12 male. Faces switch every 16 trials. Face genders are balanced. The faces were selected with over 80% congruency except for two faces with congruency of over 72%. The correlation between sound (2 conditions: standard versus variant) and target condition (go-no go) is zero. The task was piloted on healthy controls and autistic adults. All subjects performed well.

Eligibility Criteria:
Inclusion Criteria:

* Age range of 18-50 years old
* Diagnosis: autism spectrum disorder by Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) and Autism Diagnostic Interview - Revised (ADI-R)
* Intelligence quotient (IQ) \> 80
* Outpatients

Exclusion Criteria:

* Subjects with epilepsy
* Subjects with history of schizophrenia, schizoaffective disorder or other Axis 1 mental disorders, such as bipolar disorder
* Subjects reporting history of encephalitis, phenylketonuria, tuberous sclerosis, fragile X syndrome, anoxia during birth, neurofibromatosis, hypomelanosis of Ito, hypothyroidism, Duchenne muscular dystrophy, and maternal rubella
* Subjects who have received depot neuroleptic medication, or other psychoactive drugs within the past 5 weeks.