cyrilzakka/clinical-trials huggingface dataset:
Heart Rate Variability Assessment in Dialysis Patients by Acupuncture

Title of the study:Heart Rate Variability Assessment in Dialysis Patients by Acupuncture

Study period: 08/2019 - 07/2021

Institution: the Graduate Institute of Chinese Medical Science, China Medical University/ Changhua Christian Hospital,Taiwan

Aim of the study: To investigate the effect of medical acupuncture in comparison to placebo acupuncture by heart rate variability(HRV)

Design: Prospective randomized trial

Intervention: Experiment group using indwelling fixed needles, N=30 ; Control group using placebo needles, N=30

Outcome measures: International RLS Rating Scale, HRV

RLS occurs in 3-15% of the general population and in 10-30% of patients on maintenance dialysis. End-stage renal disease, a decrease in HRV is typically found, with abnormal HRV being considered an independent risk factor for mortality.While the majority of studies show an initial improvement in symptoms, longer studies and clinical experience show that either treatment efficacy decreases with time, and/or augmentation develops: dopaminergic augmentation has been reported to be the main reason for treatment discontinuation and treatment failure in RLS/WED.

The study randomly assigned to either true acupuncture treatment or placebo/sham acupuncture treatment. Each participant will undergo 12 treatments third-weekly, for a period of 4 weeks. At the end of the eighth treatment session, each participant will again fill out a IRLSRS questionnaire ,ISI and HRV test. At the end of the treatment regimen and 5weeks, participants will again fill out a IRLSRS questionnaire ,ISI and HRV test.

Eligibility Criteria:
Inclusion Criteria:

* Dialysis patients with RLS
* The symptoms expressed ≧ 3 months and more than twice per week.
* A score of at least 20 corresponding to severe RLS ( International Restless Legs Syndrome Rating Scale, IRLSRS).Dialysis patients with RLS

Exclusion Criteria:

* Idiopathic RLS
* Other movement disorders, various psychiatric and organic disorders, cognitive impairment, or bleeding disorders, on anticoagulant therapy, or cardiac pacemaker.
A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis

A multicenter,randomized,single-blind, placebo-controlled,phase 4 clinical trial to evaluate the efficacy and safety of andrographolide sulfonate in patients with acute exacerbation of chronic bronchitis

The patient after passing the screening, with the ratio of 1:1, were randomly assigned to experimental group or control group. Experimental group: on the basis of Conventional Therapy,Xiyanping injection(andrographolide sulfonate) 10-20ml/d, With 0.9% normal saline 100ml-250ml diluted intravenous drip (not with other drugs in the same container mixed use), control drip speed per minute of 30-40 drops. control group: on the basis of Conventional Therapy,Xiyanping injection simulation(0.9% normal saline) 10-20ml/d, The treatment method is the same as the experimental group.

Eligibility Criteria:
Inclusion Criteria:

* 1.18-75 years, males or females;
* 2.patients met the acute exacerbation of chronic bronchitis diagnosis;
* 3.Patients with bronchitis were acute attacked 2-6 days,who had a history of chronic bronchitis more than 2 years.
* 4. Patients compliance is good, written informed consent was obtained from all participants before the study.

Exclusion Criteria:

* 1.Patients had a history of andrographolide sulfonate or andrographolide allergy.
* 2.Pregnancy, lactation, and absence of contraception in women of fertile age.
* 3.Judging by the researchers, Past or present illness of patients may affect to participate in the trial or affect the outcome of the study, including cardio-pulmonary diseases, malignant diseases, autoimmune diseases, hepatorenal disease, blood diseases, nervous system diseases, immune system diseases and endocrine diseases
* 4.After checking, Patients with pulmonary tuberculosis, bronchial asthma, bronchial pneumonia, bronchiectasis, pneumoconiosis, silicosis, lung cancer, pulmonary infiltration or other allergic respiratory diseases and other chronic lung diseases
* 5.Patients using systemic steroids or other immunosuppressive therapy
* 6.Patients with severe cardiopulmonary dysfunction, abnormal liver and kidney function, blood system diseases
* 7.Patients are alcohol (daily drink alcoholic wine is more than 40g) or drug abuse or drug addicts in the past year.
* 8.Patients were participated in any study of drug trials in the last 30 days.
* 9.According to the researchers' judgment, anyone who are not suitable for the study.
MEDCEM PC and MTA in Pulpotomies of Primary Molars

The objective of the study is to evaluate and compare, clinically and radiographically,the effects of MEDCEM PC and MTA when used as pulp dressings following pulpotomy in human primary molars.


Eligibility Criteria:
Inclusion Criteria:

* healthy children
* molars showing: symptomless exposure of vital pulp by caries no clinical or radiographic evidence of pulp degeneration (excessive bleeding from the root canal, internal root resorption, inter-radicular and/or furcal bone destruction) the possibility of proper restoration of the teeth no physiological resorption of more than one-third of the root

Exclusion Criteria:

* presence of systemic pathology
* history of allergic reaction to latex, local anaesthetics or to the constituents of the test pulp dressing agents
Interpretation Performance in Chinese and Japanese Medical Consultation Scenarios

This study aims to compare the translation and interpretation performance of ChatGPT, Google Translate(GT),and UD Talk in cardiopulmonary consultations and analyze their effectiveness in addressing language barriers.The investigators hypothesize that ChatGPT and UD Talk will outperform GT in terms of accuracy and error rates.

Background： Language barriers in healthcare have a significant impact on patient safety, health outcomes, and the quality of healthcare services. With the increase in global migration, more patients are facing language challenges in foreign healthcare systems. Literature shows that providing professional interpretation services significantly improves patient satisfaction and communication quality. However, due to the high usage of ad-hoc interpreters and the shortage of professional interpreters, clinical communication quality has declined.

Study Design： This is a one-year, single-center, prospective observational study. Methods： The study will be conducted in the cardiology and pulmonology outpatient clinics at Fu Jen University Hospital. A total of 20 cardiopulmonary disease patients will be enrolled, withtheir consultation sessions recorded and transcribed into Chinese. The study will compare the three tools' performance in terms of semantic accuracy, error types, and severity, and analyze their feasibility in clinical practice. Further analysis will involve satisfaction surveys from both professional interpreters and non-native speakers living in Taiwan. The translation results will be evaluated for accuracy and error rates by 8 professional medical interpreters, with a satisfaction survey completed by a total of 16 experts and non-experts. The evaluation tool will be based on the assessment rubrics from the National Accreditation Authority for Translators and Interpreters.

Effect： It is expected that ChatGPT and UD Talk will show better translation accuracy and interpretation quality compared to GT. UD Talk is anticipated to perform better than the other two tools in real-time interpretation. The study results will provide valuable insights for future medical interpretation training and clinical applications.

Eligibility Criteria:
First part

Inclusion Criteria:

* Age over 18 years
* Patients visiting the Cardiology or Pulmonology Department at Fu Jen Catholic University Hospital from December 2024 to November 2025

Exclusion Criteria:

* Patients unable to communicate effectively as assessed by the physician
* Refusal to participate in the study

Second part

Inclusion Criteria:

* Age over 18 years
* Completed the Japanese-Chinese medical interpretation training course and has at least two years of clinical experience

Exclusion Criteria:

* Refusal to participate in the study

Third part

Inclusion Criteria:

* Age over 18 years
* Non-native Chinese-speaking Japanese residents who have lived in Taiwan for at least two years

Exclusion Criteria:

* Refusal to participate in the study
Compuflo Instrument for Thoracic ES Identification

The purpose of this pilot study is to evaluate whether the Compuflo Epidural Instrument injection pump technology, which is FDA approved for lumbar epidural anesthesia, is also capable of identifying the thoracic epidural space through measurement of pressure levels. While this device is approved by the FDA for use in the procedure of the lumbar epidural, it is not used to perform the epidural procedure but rather to measure the epidural pressure. This study will likewise measure the epidural pressure.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 to 80 years inclusive
* BMI 18.5 to 40 inclusive
* Scheduled for thoracic epidural anesthesia

Exclusion Criteria:

* Patients younger than 18 years or older than 80 years of age
* Patients with BMI less than 18.5 or greater than 40
* Contraindication to thoracic epidural anesthesia
* Allergy or hypersensitivity to local anesthetics
* Patients with preexisting nerve damage
* Patients unable to provide written informed consent
* Individuals of vulnerable populations: children, pregnant women, prisoners
Treatment of Periodontitis Stage II by Tulsi Gel

This study will be carried out to compare between the effect of 4%Tulsi gel and 1%Chlorohexidine gel as locally administered agents in the treatment of stage II periodontitis. Clinical parameters measurements, microbiological and radiographic assessment will be performed at base line, one month and 3 months after the intervention.


Eligibility Criteria:
Inclusion Criteria:

* All patients included in this study will be having Stage II Periodontitis
* Aging from 30 to 50 years old
* Free from any local or systemic risk factors that may affect the results of the study.

Exclusion Criteria:

* Long-term therapy with medications within a month prior to enrollment that could affect periodontal status or healing.
* Pregnant woman and lactating mothers.
* Patients with previous periodontal treatment including scaling and root planning and periodontal surgery in the last 3 and 6 months, respectively.
Ischemia in Patients With Non-obstructive Disease (INOCA) in Italy INOCA IT Multicenter Registry"

Prospective, interventional, multicentre, non-randomized, single-arm open-label study that aims to enroll 200 consecutive patients with suspected chronic ischemic heart disease in the absence of obstructive coronary artery disease (INOCA) at clinically indicated coronary angiography in 3 Italian centers.

During coronary angiography, these patients will be simultaneously subjected to a functional and coronary physiology study (according to the methods reported below):

* Functional evaluation with fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), Resting Full-Cycle Ratio (RFR) of angiographic stenosis\> 50%;
* In the presence of coronary angiographic stenosis \<50% or\> 50% but in the presence of a negative functional assessment (FFR\> 0.80 and iFR / RFR\> 0.90), coronary flow reserve (CFR) and index of microvascular resistance (IMR) will be measured. IMR and CFR will be assessed using intra-coronary guidance;
* In the presence of CFR\> 2.0 and IMR \<25, tests with acetylcholine will also be performed in order to evaluate the possible presence of epicardial (focal or diffuse) or microvascular spasm.


Eligibility Criteria:
Inclusion Criteria:

* Clinical presentation of chronic ischemic heart disease (IHD), requiring coronary angiography for the diagnosis
* Absence of obstructive CAD at coronary angiography
* Age \> 18 years
* Ability to provide a valid informed consent to the study procedure at the time of baseline evaluation

Exclusion Criteria:

* Clinical presentation of acute coronary syndrome (ACS) or cardiogenic shock
* Presence of obstructive CAD with at least 1 significant coronary artery stenosis, defined as diameter stenosis \>50% and FFR ≤0.80 (or iFR/RFR ≤0.89)
* Previous coronary artery bypass grafting (CABG)
* Left ventricular systolic dysfunction, defined as ejection fraction (EF) \<40%
* Severe valvular heart disease
* Pregnant or breastfeeding women
* Known hypersensitivity or contraindication to any of the drugs used for coronary physiology testing (adenosine, nitrates, acetylcholine)
* Inability or unwillingness to provide a valid informed consent to the study procedure at the time of baseline evaluation
Safety and Efficacy Study of APD125 in Patient With Insomnia

The purpose of this study is to determine the effects of APD125 in patients with sleep maintenance insomnia.


Eligibility Criteria:
Inclusion Criteria:

* Primary insomnia as defined in DSM-IV-TR, with predominant complaint of impaired sleep maintenance and confirmed by PSG
* PSQI \>/= to 5
* Qualifying screening PSG parameters
* Generally good health

Exclusion Criteria:

* History of any sleep disorder, other than primary insomnia (e.g., restless leg syndrome, narcolepsy, sleep apnea, and disorders of REM/NREM sleep)
* Any clinically significant medical condition, laboratory finding, or ECG finding
* Pregnant and/or lactating females
* History of substance abuse within 2 years or positive urine drug screen
* Positive Hepatitis B/C results or HIV markers
* Apnea-Hypopnea Index (AHI) or a Periodic Limb Movement Arousal Index (PLMAI) \> 10 as determined by screening PSG
* History of treatment with an investigational drug within the last month
* Recent travel involving crossing more than 3 time zones or plans to travel to another time zone (\> 3 time zones) during the study
PeRfusion Emergency VEiNlite Transillumination

When taking care of an emergency patient (Emergency Reception Service: UAS and Urgent Medical Assistance Service: SAMU), the installation of a peripheral venous route (VVP) is an important step. The benchmark method is the most widely used technique. This vascular access will allow the necessary therapy to be delivered quickly and efficiently. This can be difficult and sometimes doomed to failure for reasons related both to the patient (venous capital not very visible / felt or limited due to the profile of the patient), or sometimes also for reasons related to the patient. environment (limited lighting, difficult patient access). The only current alternatives lie in the use of a device such as the Intra-Bone Device (IID) or the installation of a central venous line. On the other hand, these alternatives are particularly invasive and / or very algogenic.

There are other techniques, which are more affordable and "transportable" outside the hospital. Indeed, trans-illumination with a very short training seems to be a particularly interesting alternative. It allows, thanks to LEDs in contact with the skin, to backlight the superficial veins.

It is proposed through this project to evaluate this tool for a category of patients considered "difficult" to infuse, both within hospital and outside hospital.

The main objective of the study is to assess the effectiveness of the transillumination device, compared to the absence of such a device, on the placement of a peripheral venous line (PVP) in patients with a difficult vascular approach and managed in the emergency room and whose clinical condition does not require the installation of an intraosseous device.

This is a multicenter, prospective, controlled, randomized and open clinical study, according to a cross-over design. The intervention evaluated is the placement of a PVR using the trans-illumination device. The control intervention is the placement of a PVR without this device, according to the reference method, which is the benchmark method.

400 patients presenting to the emergency room will be included in the centers of Nancy, Toul and Pont-à-Mousson.

Depending on their randomization group, nurses will perform peripheral venous insertion by the transillumination method or by the control method.


Eligibility Criteria:
Inclusion Criteria:

\>= 18 years old

* extrem body mass index
* hypotension
* toxicomania
* limited ponction site
* hypotherm patient
* dehydrated patient
* generalized edema
* non-supportive environment

Exclusion Criteria:

* parturient / pregnant female / breastfeeding mother
* unemancipated minor
* adults under legal protection
* person under judicial protection, guardianship or curatorship
Using Music During Lumbar Medial Branch Block Procedure

The purpose of this study is to determine if music therapy during interventional lumbar medial branch blocks for chronic lower back pain will lower pain scores and anxiety levels, while increasing patient desire for repeat procedure as well as patient satisfaction.

Subjects will be put into 1 of 2 groups, Music or the Control Group (no music). The music group will listen to patient's preferred music on Pandora station broadcast using Headphones or Wireless Earbuds with Tablet or Computer. Hearing impaired patients will have an option of non-earbud headphones. . Earbuds or headphones will be used regardless of music therapy playing. . The control group will be provided earbuds or alternative headphone as well, however, with no music. The sound environment will be standardized for procedure by closing procedure room door and minimizing extraneous sounds (i.e. from equipment, alarms, etc.,).

Eligibility Criteria:
Inclusion Criteria:

* Age\> or equal to 18
* History of documented chronic lower back pain

Exclusion Criteria:

* Patient refusal
* Deafness (unless corrected with a hearing aid)
* Initial Pain Score \< 3
* Prior Lumbar Medial Branch Blocks/Radiofrequency ablation therapy
* Any woman who is currently pregnant.
Internet-based Cognitive Behavior Therapy After Myocardial Infarction

The overall aim and primary objective is to evaluate the effects on level of depression and anxiety of an Internet-based CBT-program in depressed and/or anxious patients after a myocardial infarction (MI).

Major or minor depressive disorders and anxiety disorders are present in many patients with cardiovascular disease (CVD) and are associated with adverse cardiovascular outcomes, even after controlling for other risk factors. 500 patients with symptoms of anxiety and/or depression after MI will be randomized either to a 14 week Internet-based CBT-program or to treatment as usual (TAU) which is the control condition. A reference group of 250 participants without depressive or anxiety symptoms will also be studied during TAU. Data will be collected before, after and 7 months after treatment. Anxiety and depression according to ratings on the Hospital Anxiety and Depression Scale (HADS) are the primary outcome measures.

Eligibility Criteria:
Inclusion Criteria:

* Patients younger than 75 years with a recent acute MI (\< 3 months)
* Depression and/or anxiety score of \> 7 on one or both of the HADS subscales (concerns only the intervention, not the reference group)

Exclusion Criteria:

* Patients that are scheduled for a coronary artery bypass surgery (CABG)
* Unable or unwilling to use computer or Internet
* Difficulties in reading or understanding Swedish
* A life expectancy of less than a year
* Anticipated poor compliance (multi-disease, substance abuse etc.)
* Highly depressed or suicidal (MADRS-score \> 29 or MADRS item 9 \> 3)
Bedside Monitoring to Identify Impaired Cerebral Autoregulation in Women with Postpartum Hypertension

The purpose of this research study is to develop a protocol for NIRS-based bedside monitoring to identify impaired cerebral autoregulation in women admitted to the high-risk obstetrics unit with postpartum hypertension. The investigators will then pilot this protocol in 10 patients with high-risk neurological features, such as headache.

Maternal neurological complications are a leading cause of postpartum severe maternal morbidity and maternal mortality (SMM/MM). The lack of biomarkers to identify women at highest risk of these rare, but devastating postpartum complications, including stroke, seizures, and posterior reversible encephalopathy syndrome, has impeded efforts to prevent neurological SMM/MM.

Impaired cerebral autoregulation may be such a biomarker. Preliminary results using transcranial Doppler (TCD) based techniques to quantify cerebral autoregulation have demonstrated severely impaired cerebral autoregulation in the postpartum period in some women. However, TCD is operator dependent, and cannot be used for extended monitoring due to discomfort. In contrast, near-infrared spectroscopy (NIRS) is fully automated and can be continued for hours at the bedside. Identifying personalized blood pressure (BP) targets using NIRS has been shown to improve outcomes in acute stroke patients, another population with impaired cerebral autoregulation. However, this method has not been applied in postpartum women.

This is a single center feasibility study that will include up to 10 women. Postpartum women admitted to the obstetrics high-risk stepdown unit for management of postpartum hypertension will be eligible for this study. Informed consent will be obtained from participants prior to enrollment in the study.

Eligibility Criteria:
Inclusion Criteria:

* Women who have given birth within the previous 12 weeks
* Admitted to the high-risk inpatient obstetrics unit for management of hypertension
* With headache or other neurological symptoms such as vision changes

Exclusion Criteria:

* Acute ischemic stroke
* Intracerebral or subarachnoid hemorrhage
* Eclamptic seizures
* Any other neurological complication requiring transfer to the neurological intensive care unit or stroke stepdown unit
* History of Reynaud's syndrome
Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas


Eligibility Criteria:
Inclusion Criteria:

* age 18 -70

Exclusion Criteria:

* contraindication to MRI
* Resting oxygen saturation \<95%
* Volunteers requiring bronchodilators less than 4 hourly
* additional respiratory diagnoses
* pregnancy
Internal Iliac Artery Ligation Before Cesarean Hysterectomy in Morbidly Adherent Placenta

40 pregnant females at term diagnosed with morbidly adherent placenta and planned for elective cesarean section were recruited and randomized to 2 groups. Group A: Internal iliac ligation followed by cesarean hysterectomy. Group B: cesarean hysterectomy.


Eligibility Criteria:
Inclusion Criteria:

* Placenta previa accreta
* Previous 2 cesarean section
* completed her family
* Hemoglobin \> 11 gm/dl
* Elective cesarean hysterectomy

Exclusion Criteria:

* Anemia ( Hemoglobin \< 11 gm/dl)
* Not completed her family
* BMI \> 35 Kg/m2
* Bleeding tendency
* Emergengy cesarean section
* Thrombophilia