cyrilzakka/clinical-trials huggingface dataset:
Fostering Resilience to Psychosocial and HIV Risk in Indian MSM

India has the world's third largest HIV epidemic and men who have sex with men (MSM) are an identified high risk group. MSM in India face unique psychosocial stress underlying the context of HIV risk. To maximize the potential impact of an HIV prevention intervention, the purpose of this study is to test, in a two-arm randomized controlled efficacy trial, a behavioral intervention that addresses both psychosocial / contextual stress and reducing participant's risk for HIV.

India has the world's third largest HIV epidemic, and MSM in India have an estimated seroprevalence of 14.7%. Many HIV prevention efforts for MSM in India are limited to condom distribution and HIV education, with no existing efficacy trials of HIV prevention interventions and therefore no evidenced based HIV prevention interventions this population. MSM in India are hidden, stigmatized, and face considerable psychosocial stressors, including pressure to marry, which potentially increases the risk for HIV transmission to their wives.

This proposal is the culmination of our ongoing, successful \> 10-year community based research collaboration with two NGOs dedicated to HIV prevention among MSM, Sahodaran (Chennai) and The Humsafar Trust (Mumbai), and investigators from the India Council of Medical Research (ICMR), National Institute for Research in Tuberculosis (NIRT) in Chennai. Our work, including extensive community advisory input, has identified self-acceptance as a key resilience variable that protects against both HIV risk and psychosocial distress. A field test and pilot randomized controlled trial of our behavioral intervention that addresses both HIV risk and self-acceptance showed high participant acceptability and feasibility of study procedures, and success reducing HIV sexual risk behavior.

The current study is a two-arm randomized controlled trial to reduce HIV, STI and sexual transmission risk compared to HIV/STI counseling and testing alone.

Eligibility Criteria:
Inclusion Criteria - One of the following must be true:

* Participant has had anal sex with 4 or more male partners (protected or unprotected) in the past 4 months.
* Participant has had condomless anal sex with a man who was HIV unknown or serodiscordant in the past 4 months.
* Participant has a history of transactional sex activity in the past 4 months.
* Participant has been given a diagnosis of an STI in the past 4 months.

Exclusion Criteria:

* Participant does not identify as male
* Younger than 18
* Is unable to understand or consent to the procedures
* Is deemed by the local PI or study staff to be engaging in deception about the inclusion/exclusion criteria.
Effectiveness of Analgesia in Total Knee Arthroplasty

The purpose of this study is to compare the analgesic effectiveness of three techniques: the femoral nerve block, intraarticular infiltration or a combination of both in the control of pain in total knee arthroplasty (KA). The hypothesis to be tested in this study is that the performance multimodal postoperative pain KA combining two analgesic techniques to obtain better analgesia than when applied separately.


Eligibility Criteria:
Inclusion Criteria:

* intervention program for total knee arthroplasty
* ASA I, II, III
* over 65 years old

Exclusion Criteria:

* ASA \> III
* patients who refuse the realization of technical loco-regional anesthesia
* presence of coagulopathy or impaired hemostatic function
* BMI \> 35
* Serious intraoperative complications
* patients undergoing bypass and aortic-femoral or femoro popliteal bypass operated leg
* patients treated for chronic pain diagnosed processes, different knee osteoarthritis
24-Hour Ambulatory Blood Pressure Monitoring in Community Pharmacies

This study is designed to explore the feasibility of providing 24-hour ambulatory blood pressure monitoring in community pharmacies. The investigators hypothesize it will be feasible for community pharmacies to provide the service to assist medical providers in the diagnosing and management of high blood pressure. The investigators will also survey participants regarding their experience with the service as well as conduct interviews with participating pharmacists and medical providers to understand their views and opinions on the feasibility of the service.


Eligibility Criteria:
Inclusion Criteria:

* Adults greater than or equal to 18 years of age suspected by their physician of having "white coat" or "masked" hypertension (HTN), hypotension symptoms due to antihypertensive therapy, uncontrolled sustained HTN, requiring additional confirmation of an initial diagnosis if HTN, or resistant HTN.

Exclusion Criteria:

* Documented past medical history of persistent atrial fibrillation, on hemodialysis, pregnancy, or dementia.
Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cells Implantation in Patients With Critical Limb Ischemia

The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with critical limb ischemia


Eligibility Criteria:
Inclusion Criteria:

* At least 6 months since the onset CLI(Chronic ASO or Buerger disease)
* Patients with luminal stenosis \> 50% by leg angiography
* Age is between 20 and 80
* Patients whose Rutherford's class is II-4, III-5 or III-6 (Patients with rest pain or ischemic ulcer/necrosis)
* Patients for whom angioplasty and bypass surgery are not indicated because of anatomical or procedural reasons or frequent reocclusion/restenosis following traditional revascularization
* Patients who can give informed consent themselves in writing

Exclusion Criteria:

* Previous or current history of neoplasm or comorbidity that could impact the patient's survival
* Detection of proximal source of emboli including atrial fibrillation
* Primary hematologic disease, including hypercoagulable states
* Detection of proliferative retinopathy
* Entrapment syndrome
* Alcohol abuse, cocaine amphetamine etc.
* Detection of osteomyelitis
* Uncontrolled DM
Bioequivalence Study of Naproxen Sodium 220 mg & Pseudoephedrine HCl 120 mg ER Tablets of Dr. Reddy's Under Fed Conditions

The purpose of this study is to assess the bioequivalence of Naproxen sodium 220 mg + Pseudoephedrine Hydrochloride 120 mg Extended Release tablets of with Aleve Cold and Sinus in healthy adult human subjects, under fed conditions.

Open randomized, two treatment, two period, two sequence, single dose, crossover study of 26 healthy human adult subjects under fed conditions with a washout period of 27 days.

Eligibility Criteria:
Inclusion Criteria:

Subjects must fulfill all of the following criteria to be considered for inclusion into this study:

* Subjects will provide written informed consent.
* Subjects must be healthy human beings within 18-45 years of age (inclusive) weighing at least 50 kg.
* Subjects must be within ±15% of ideal body weight in relation to height according to Life Insurance Corporation of India height-weight chart for non- medical cases.
* Subjects must be of normal health as determined by medical history and physical examination performed within 21 days prior to the commencement of the study.
* Have normal ECG, X-ray and vital signs.
* Availability of subject for the entire study period and willingness to adhere to protocol requirements as evidenced by written informed consent.

If subject is a female volunteer and

* Is of child bearing potential practicing an acceptable method of birth control for the duration of the study as judged by the investigator(s), such as condoms, foams, jellies. diaphragm,intrauterine device (IUD), or abstinence.
* Is postmenopausal for at least 1 year.
* Is surgically sterile (bilateral tubal ligation, bilateral oophorectomy, or hysterectomy has been performed on the subject.

Exclusion Criteria:

The subjects will be excluded under following conditions:

History or presence of significant:

* Cardiovascular, pulmonary, hepatic, renal, hematological, gastrointestinal, endocrine,immunologic, dermatologic, musculoskeletal, neurological or psychiatric disease.
* Alcohol dependence, alcohol abuse or drug abuse within past one year.
* Moderate to heavy smoking (\>10 cigarettes/day) or consumption of tobacco products.
* Asthma, urticaria or other allergic type reactions after taking any medication.

Subjects who through completion of the study, would have donated in excess of

* 500 ml of blood in 14 days, or
* 500 - 800ml of blood in 14 days (unless approved by the Principal Investigator)
* 1000 ml of blood in 90 days
* 1250 ml of blood in 120 days
* 1500 ml of blood in 180 days
* 2000 ml of blood in 270 days
* 2500 ml of blood in 1 year

Subjects who have participated in another clinical trial within 3 months of study start.

Subjects who have:

* Systolic blood pressure less than 90 mm of Hg and higher than 150 mm of Hg
* Diastolic blood pressure less than 60 mm of Hg and more than 95 mm of Hg. Minor deviations (1-3 mm Hg) at check-in may be acceptable at the discretion of the physician/investigator.
* Pulse rate below 50/min. and above 105/min. Female volunteers demonstrating a positive pregnancy screen or currently breast-feeding.
Evaluating Validity of Clinical Criteria for Requesting Chest X-Rays in Trauma Patients

The purpose of this study is to identify the clinical criteria for requesting a chest x-ray in a patient with blunt trauma and its findings such as clinical signs with a high sensitivity could be used in a larger study to codify the final criteria.

At present, a Chest x-ray is obtained from all trauma patients having suspicion to chest trauma. The indications for such radiographs are not well defined. This results in a large number of unnecessary chest radiographs being obtained. Our goal was to identify the clinical criteria for requesting a chest x-ray in a patient with blunt trauma and its findings such as clinical signs with a high sensitivity could be used in a larger study to codify the final criteria.

Eligibility Criteria:
Inclusion Criteria:

* Every patient with blunt trauma to chest

Exclusion Criteria:

* nothing
Screening Scottish Swimmers for Asthma and Rhinitis

The Scottish National and District swimming teams will be screened for asthma and rhinitis using both mannitol challenge and sport-based exercise challenge.


Eligibility Criteria:
Inclusion Criteria:

* member of the Scottish national and district swimming team
* informed consent obtained

Exclusion Criteria:

* pregnant, lactating or planning to become pregnant
* concomitant use of medicines (prescribed, over-the-counter or herbal) that may interfere with the trial.
* any clinically significant medical condition, as deemed by the clinical investigators, which may endanger the health of the participant or jeopardise the protocol.
* inability to comply with the protocol.
The Effects of Dry Needling & Kinesio Tape on Anterior Knee Pain

Patellofemoral Pain Syndrome(PFPS) is one of the most common health-related complaints in today's societies. Myofascial pain syndrome(MPS) have been attributed as the main cause and primary source of musculoskeletal pain. Trigger point of the vastus lateralis muscle may pull the patella superiorly and laterally, increasing compression of the patellofemoral joint during physical activities, result in PFPS and anterior knee pain. The purpose of this study was to investigate the effects of Dry Needling \& kinesio tape on trigger point of vastus lateralis muscle in PFPS subjects.

Pain intensity, pain pressure threshold and Disability of knee were collected at base line and at the end of treatment sessions.

Eligibility Criteria:
Inclusion Criteria:

1. Presence of a palpable taut band in muscle.
2. Presence of a hypersensitive tender spot in the taut band.
3. Reproduction of the typical referred pain pattern of the trigger point in response to compression. To detect active trigger point, trigger point pressure tolerance was assessed using a mechanical pressure algometer. The investigator applied continuous pressure with the algometer with an approximate pressure of 2.5 kg/cm2.
4. Spontaneous presence of the typical referred pain pattern and/or patient recognition of the referred pain as familiar.

5- Pain of at least 30 mm on a visual analogue scale (VAS) from 0 mm (no pain) to 100 mm (worst imaginable pain).

Exclusion Criteria:

1. had a history of fracture of knee joint, dislocation of patella
2. previous knee or ankle surgery
3. had a history of neurologic condition
4. having physical therapy within the past month before the study
5. pregnancy
6. taking anticoagulants (e.g. warfarin)
7. local infection
Medicine-induced Cardiac Hemodialysis on COVID-19

The clinical trial studies the human pathogen of SARS-CoV-2, with a specificity in the circulating Spike 2 protein in the human system. The clinical trial hypothesizes that SARS-CoV-2 human pathogen arises from immune attacks, underlying the severe physiological symptoms that can be lethal. It further hypothesizes that the vaccines do not deal with the Spike 2 protein that causes the immune attacks.


Eligibility Criteria:
Inclusion Criteria:

* No mRNA vaccinated poisoning have been included currently, but scientific evidence suggest the methods of vaccination are irrelevant to the conditions. It is theorized that the more advanced the vaccine production technology, the deeper the poisoning.

Exclusion Criteria:

* healthy individuals with no myocarditis or unvaccinated without infection by SARS-CoV series
* persons with diabetes (Paxlovid and PrEP treatments can be applied according to availability)
Evaluation of Left Ventricular Function After Treatment of Diabetic Foot Ulcers Using Longitudinal Strain Echocardiography

Early detection of heart failure as a macrovascular complication of DM offers the best chance of cure in these patients. Nowadays, the most common method for detecting heart failure is measuring left ventricle ejection fraction (LV-EF), by echocardiography. Despite the easy application of LV-EF, it remains normal in early stages of cardiac disease and it's considered as heart failure with preserved LVEF (HFpEF). We hope that, Strain monitoring as a new method enables us to detect the early minimal changes in myocardium.

The aim of study evaluate the effect of treatment of diabetic foot ulcers in improving heart function by strain echocardiography than conventional transthoracic echocardiography in Assiut university hospital.

Diabetes mellitus (DM) is a chronic, metabolic disease with hyperglycemia that occurs as a result of deficiency or resistance of insulin hormone secreted from the pancreas. Diabetic foot ulcer (DFU)is a frequent macrovascular complication has a high incidence and mortality rate. According to research statistics, the mortality rate of patients with foot ulcers after 5 years is 2.5 times higher than that of patients without such ulcers. Heart failure develops in diabetic patients over twice higher than non-diabetics both directly, by impairing cardiac function, and indirectly, through associated diseases such as hypertension, coronary disease, renal dysfunction, obesity, and other metabolic disorders.

Based on a recent study, DFU treatment improves cardiac function assessed by strain measurements . At present, few data is available about the ability of strain echocardiography in prediction of systolic dysfunction in DFU, and the possible effect of the treatment of these patients on their cardiac function. So, we decided to evaluate the effect of treatment of diabetic foot ulcers in improving heart function by this new method-strain echocardiography.

Eligibility Criteria:
Inclusion Criteria:

* Diabetic Patients with DFU, who were diagnosed by a vascular surgeon based on Diabetic Foot Study Group guidelines.
* Diabetic Patients were who used anti-diabetic oral medication, insulin or who had fasting blood glucose (FBS) ≥ 126 mg/dl for at least two times at age group 18 to 50 years at Assiut university hospital

Exclusion Criteria:

* Patients with acute or advanced stage of renal, hepatic or pulmonary diseases, acute coronary syndrome, known coronary artery disease ,infectious disease in the last two weeks, coagulopathy, history of a hemorrhagic stroke, severe valvular disease , heart failure (EF\<45%).
* at age group below 18 or above 50 years old.
Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes

The aim of this study is to assess the feasibility of visualizing the internal thoracic artery (ITA), establishing the normogram for ITA pulsatility index (PI), resistance index (RI) and acceleration/ejection time (AT/ET) at 24-32 weeks.

Background: The internal thoracic artery arises from the subclavian artery as the first branch. It travels downward on the inside of the rib cage and then gives off six main branches; mediastinal, thymic, pericardiacophrenic, sternal, perforating and intercostal branches.

In literature, there are so many articles that have been focused on thymus size in pregnancies complicated with diabetes mellitus, fetal growth restriction, preterm rupture of membranes and so on. To the best of our knowledge, there is no paper about fetal ITA whose branch are feeding vessel of thymus and ITA Doppler velocity. The arteries supplying the thymus are branches of the internal thoracic, and inferior thyroid arteries. As far as it has been known, growing of a tissue depends on increased blood flow. Before detecting possible blood-flow changes in fetuses complicated with great obstetrics patologies, the investigators should obtain normal values of ITA Doppler velocity.

Eligibility Criteria:
Inclusion Criteria:

* singleton pregnancy
* having no fetal anomalies
* healthy pregnant women age \>17 and \<45 years
* between 24th-32nd gestational weeks

Exclusion Criteria:

* fetuses with congenital aneuploidy or structural malformation
* underlying chronic diseases
* pregnant women complicated with gestational diabetes, Type 1-2 DM, hypertension (pregnancy-induced; chronic; preeclampsia), malignancy
* pregnancy complicated with preterm premature rupture of membranes, preterm labour, fetal growth restriction and another obstetric complication
A Study to Assess the Efficacy, Safety and Tolerability of Tegaserod Alone and in Combination With Omeprazole Given Orally in Patients With Symptoms of Symptomatic Gastroesophageal Reflux Disease (sGERD)

Gastroesophageal Reflux Disease (GERD) is a common disorder caused by the reflux of gastric (stomach) acid into the esophagus. The exposure of the lining of the esophagus to the acid will cause damage to the esophagus over time. The symptoms of GERD include heartburn and acid regurgitation This study will determine if Tegaserod alone and in combination with omeprazole is safe and relieves the symptoms of heartburn.


Eligibility Criteria:
Inclusion Criteria:

* History of physician diagnosed GERD
* Heartburn and Regurgitation 3 Days during the week prior to screening

Exclusion Criteria:

* History of erosive esophagitis, Barrett's esophagus, esophageal stricture, scleroderma, Zollinger-Ellison Syndrome, known primary disorder
* History or presence of infection or inflammation of the small or large intestine, gastrointestinal malignancy, history of upper GI surgery
* Use of PPI during the last four weeks prior to screening

Other protocol-defined inclusion/exclusion criteria may apply.
Tissue-of-origin Directing Therapy in Patients With Cancer of Unknown Primary

This study is designed to evaluate the value of tissue-of-origin (ORIGIN-PanCA○R) profiling in predicting primary site and directing therapy in patients with cancer of unknown primary.


Eligibility Criteria:
Inclusion Criteria:

* had a diagnosis of cancer of unknown primary (CUP) after a standard evaluation (medical history, physical examination, blood counts, chemistry profile, chest/abdomen computed tomography scans, positron emission tomography scan, and directed evaluation of all symptomatic areas). Patients were required to have one of the following histologies: adenocarcinoma, poorly differentiated neoplasms, poorly differentiated carcinoma, squamous carcinoma. Sufficient archived biopsy tissue from a surgical or core needle biopsy was required to perform the molecular profiling assay. Eastern Cooperative Oncology Group performance status of 0 to 2; no previous systemic therapy; measurable or evaluable disease (RECIST); and adequate organ function.

Exclusion Criteria:

* carcinoma limited to single site which can be potentially cured by surgery of radiotherapy.patients with symptomatic brain metastases, active clinical severe infection
Study the Signs of Ocular Degeneration in a Population Cohort (Dijon 3C Montrachet Cohort)

The aim of the study proposed in Dijon is above all to focus on the possible relationship between age-related ocular pathologies (AMD and glaucoma) and et les degenerative neurological and cardiac pathologies.

The principal objective is to seek in subjects who have undergone cerebral MRI and echocardiography, associations between the thickness of postganglionic fibers measured by Optical Coherence Tomography at the 7th year (n=1500) and signs of cerebral impairment (psycho-cognitive tests, circulation time, MRI signs). This association will be studied after taking into account the principal environmental (particularly dietary) and genetic risk factors.


Eligibility Criteria:
Inclusion Criteria:

* Persons who have given their written consent
* Persons who are taking part in the Dijon 3C study

Exclusion Criteria:

* Persons who are not registered with social security agency
* Persons who are unable to sit upright during a consultation
Survival Validation and Gene Mutations of N Descriptors in the Ninth Edition of the TNM Classification for Lung Cancer

The International Association for the Study of Lung Cancer Staging Committee recently unveiled the ninth edition of TNM staging system for lung cancer. This study aims to explore survival outcomes, stage grouping, and gene mutations in N descriptors of this new classification system.


Eligibility Criteria:
Inclusion Criteria:

Pathological N2.

Exclusion Criteria:

Patients undergoing neoadjuvant chemotherapy
Feasibility of the Mindfulness-Based Stress Reduction Intervention for Black Women Living With HIV Supplement

In our Supplement Aim we will conduct a two-arm randomized pilot test of the adapted intervention compared to a usual care control group among 30 African American/Black women with HIV (15/arm) to assess the feasibility and acceptability of the mindfulness-based stress reduction among women with HIV with mild cognitive impairment. Feasibility will be assessed by our ability to (1) recruit, randomize, and retain participants and (2) deliver the intervention per the manual, as well as (3) participants adherence to home practices and assignments. Acceptability will be assessed via qualitative data (focus group input regarding participants' satisfaction with the intervention and intent to continue using the practices), as well quantitative data (satisfaction survey).


Eligibility Criteria:
Inclusion Criteria:

* Cisgender females
* HIV seropositive
* 18 years of age or older
* English speaking
* An active patient at the local HIV ambulatory clinic in Alabama.
* No history of neurological (including dementia diagnosis)
* No history of severe psychiatric (e.g., schizophrenia or bipolar disorder) disorders

Exclusion Criteria:

* Non-English speaking
* Appear temporarily impaired (e.g., intoxicated)
* Not willing to or legally unable to provide informed consent.