cyrilzakka/clinical-trials huggingface dataset:
The Study of Effectiveness of rTMS on Rumination and Anhedonia in Patients With Major Depressive Disorder

Rumination is significantly frequent in major depressive disorder. However, not a lot of studies have investigated the effects of repetitive transcranial magnetic stimulation on rumination and its electrophysiological correlates. This study recruited 61 participants who were randomly assigned to sham, bilateral, or unilateral stimulation groups to investigate the potential differences between these stimulation protocols and changes in the behavioral and electrophysiological outcomes after treatment.

This study aims to compare the effect of unilateral and bilateral rTMS on the reduction of rumination and anhedonia and their associated neural networks. In a randomized double-blind trial, 65 patients with depressive disorder in Atieh Clinical Neuroscience Center are assigned to three groups. The first group receives bilateral rTMS for 20 sessions on right and left DLPFC; the second group receives unilateral rTMS for 20 sessions on LDLPFC; third group receives sham rTMS for 10 sessions. In this group, the stimulation parameters are similar to that in the actual rTMS group, except that the coil angel is 90° and perpendicular to the head. Rumination and anhedonia symptoms will be measured by the Ruminative Responses Scale (RRS) and Snaith-Hamilton Pleasure Scale (SHAPS) in the baseline and after the 20th session. In order to investigate the neural networks associated with rumination and anhedonia, EEG of patients will be recorded at the first session and at the end of the treatment.

Eligibility Criteria:
Inclusion Criteria:

* Outpatients male and female with the range of 18-65 years of age
* The diagnosis of Major depressive disorder according to DSM-V
* Having BDI\>18
* Having stable symptoms as defined by not requiring a change in medication for at least 4 weeks
* Completion of consent form
* Being under supervision of a psychiatrist

Exclusion Criteria:

* The history of rTMS treatment for any reason
* Cardiac pacemaker
* The risk of seizure with any reasons
* Pregnancy
* High risk of suicide
* Intracranial implant and other ferromagnetic materials close to the head
Assessment of Automatic Tourniquets for Soldiers During Wartime

The goal of this clinical trial is to compare usability and performance of automatic tourniquets (AUT) and standard mechanical tourniquets (CAT) in healthy adults. The main questions it aims to answer are:

* Are AUTs effective in occlusion of blood flow
* Are AUTs easy to use

Participants will be asked to place AUT and CAT on their upper limbs and lower limbs (8 applications overall).

Following each application, the following parameters will be assessed:

1. Limb blood flow
2. Ease of use

Researchers will compare the results of the AUT and CAT to see if AUT is as effective as CAT in blood occlusion, and if AUT is easy to use as the CAT.

The goal of this clinical trial is to compare usability and performance of automatic tourniquets (AUT) and standard mechanical tourniquets (CAT) in healthy adults. The main questions it aims to answer are:

* Are AUTs effective in occlusion of blood flow
* Are AUTs easy to use

Participants will be asked to place AUT and CAT on their upper limbs and lower limbs (8 applications overall).

Eligibility Criteria:
Inclusion Criteria:

-Soldier in active service or active reserve service.

Exclusion Criteria:

* Muscle disorders
* Peripheral nerve disorders
* Skin diseases of the limbs
* Limb surgery in the past
* Rickets
* Hypertension
Study to Determine Effectiveness of Activation Mist on Facial Skin Wrinkles

To determine the effect of Activation Mist (AM) on skin wrinkles and appearance.

This study aims to study the effects of Activation Mist ( AM) on skin wrinkles. It contains a proprietary blend of minerals and nutritional supplements which is patented as "Liquidized Infrared Negative Ion Activation Energy". Active ingredients include sodium bicarbonate, potassium bicarbonate, sodium carbonate, strontium carbonate, gold nanoparticles, calcium, germanium, selenium , zinc, sugar and water. When applied to the skin , it has been shown to reduce the appearance of wrinkles by stimulation of skin fibroblasts to produce new collagen while removing aging dermis cells, facilitate the production of fibrillin proteins and protect the skin from ultraviolet rays.

Eligibility Criteria:
Inclusion Criteria:

1.Male and female subjects aged 30 to 80 years of age with significant facial wrinkles as assessed by the study physician.

Exclusion Criteria:

1. Women who are pregnant or lactating.
2. Subjects with skin conditions that are deemed by the investigator to interfere with the results of this study , including but not limited to: uncontrolled acne, rosacea, atopic dermatitis.
3. Subjects with clinically significant cardiovascular, neurological, renal, endocrine or hematological abnormalities uncontrolled on current therapy.
4. Subjects with history of skin malignancy
5. Subjects with signs of recent sunburn
6. Use of any of the following medications, within 1 week specified of visit 1

   1. Systemic steroids
   2. Topical steroids used on the face
   3. Topical facial preparations including but not limited to: salicylic acid and other acne products, tacrolimus, pimecrolimus.
Effects of Replacing Starchy Vegetables and Refined Grains With Beef on Cardio-metabolic Disease Risk Factors (S53)

The purpose of this study is to assess the effects of replacing starchy vegetables and refined grains with beef in a vegetarian diet on cardio-metabolic disease risk factors in adults in a cross-over, randomized controlled feeding trial.

The purpose of this study is to assess the effects of replacing starchy vegetables and refined grains with beef in a vegetarian diet on cardio-metabolic disease risk factors in adults in a cross-over, randomized controlled feeding trial. The hypothesis is that isocalorically replacing predominantly starchy vegetables and refined grains with 6 oz. of beef/day will enhance improvements in cardiometabolic disease risk factors, particularly atherosclerotic-promoting lipids and lipoproteins. It is also hypothesized that participant satisfaction and acceptance of a healthy eating pattern with 6 oz. of beef per day will be higher compared to without beef.

Eligibility Criteria:
Inclusion Criteria:

* Male or female
* 30-69 years old
* BMI 25-37 kg/m2
* Total cholesterol \<260 mg/dL
* Low-density lipoprotein cholesterol \<190 mg/dL
* Glucose \<110 mg/dL
* Systolic/diastolic blood pressure \< 140/90
* Body weight stable for 3 months prior (±3 kg)
* Stable physical activity regimen 3 months prior
* Medication use stable for 6 months prior
* Non-smoking
* Not drinking more than 2 alcoholic drinks per day
* Non-diabetic
* Not lactose-intolerant
* Not acutely ill
* Non-pregnant and not lactating.
* Participants must be willing and able to consume the prescribed diets (lacto-ovo vegetarian and omnivorous).

Exclusion Criteria:

* \<30 or \>69 years old
* BMI \<25.0 or \>37 kg/m2
* Fasting serum total cholesterol \> 260 mg/dL
* Low-density lipoprotein cholesterol \>189 mg/dL
* Glucose \>110 mg/dL
* Systolic/diastolic blood pressure \> 140/90
* Body weight stable for \<3 months prior (±3 kg)
* Stable physical activity regimen \< 3 months prior
* Medication use unstable for 6 months prior and using medications
* Smoking
* Drinking more than 2 alcoholic drinks per day
* Diabetic
* Have renal failure
* Have liver failure
* Have cardiovascular events (myocardial infarction or stroke) during the 6 months prior to the study
* Pregnant or lactating
Postpartum Hypertension Study

The purpose of this study is to assess which blood pressure medication (intravenous labetalol or oral nifedipine) works better in treating severely elevated blood pressure in women who have just delivered a baby.

Hypertensive emergencies cause significant maternal morbidity and mortality in the postpartum period. In order to reduced these risks, the recommendation is to treat women with severe range blood pressure with either intravenous labetalol or oral nifedipine; it is unclear which medication is superior. The objective of this study is to prospectively enroll women who have hypertensive emergencies in the postpartum period; women will be randomized in a 1:1 fashion and treated with one of the two antihypertensives to see which one works better.

Eligibility Criteria:
Inclusion criteria

* Patients admitted to labor and delivery (L\&D) with blood pressure (BP) in severe range, defined as a systolic ≥160 mm Hg and/or diastolic ≥110 mm Hg
* Postpartum, immediately to 6 weeks postpartum
* With a prior diagnosis of chronic hypertension (not on medication) or hypertensive disorder of pregnancy

Exclusion criteria

* They may not have previously had exposure to either study medication within the previous 24-hour period.
* Patients with a known atrial-ventricular heart block or moderate to severe bronchial asthma will be excluded, or other contraindication to receiving either study medication
Effect Study of Optimized Intervention to Heroin Addicts

The purpose of this study is to explore barriers and determine whether optimizing protocol is effective in the treatment of heroin dependence in community-based MMT clinics.

Drug dependence is one of the most serious public health problems worldwide. In China, among more than 100, 0000 registered drug addicts mostly are heroin dependence. Drug dependence post great risks to physical condition, their family and society, and can lead to infectious disease transmission. Though almost 500 MMT clinics which can offer MMT service to heroin addicts have been set up, there are still some problems, for example, poor compliance, high rate of dropping out and relapse which affect the service delivery to them. The guideline developed by WHO focused on psychotherapy to opiate addicts with MMT. So delivery of a set of comprehensive, integrated psychotherapy to opiate addicts is very critical in such methadone clinics.

Eligibility Criteria:
Inclusion Criteria:

* clinical diagnosis of heroin dependence
* must be able to take methadone

Exclusion Criteria:

* schizophrenia and mood disorder
* physical disabilities who could not come to take part in psychotherapy sessions.
Benign Paroxysmal Positional Vertigo in Older Adults

Despite the growing research on Benign Paroxysmal Positioning Vertigo (BPPV), the impact and treatment efficacy on balance, physical activity (and consequently) frailty in elderly is lacking. Also, the added value of the video Head Impulse Test (vHIT) in this population has never been studied before. With insights gained from this research, we hope to contribute to an efficient treatment of BPPV in this growing population and to minimize its impact and healthcare burden.


Eligibility Criteria:
Inclusion Criteria:

* Persons ≥ 65 years old
* Able to stand independent for at least 30 seconds
* Able to walk (with or without) walking aid for at least 10 meters
* Patients diagnosed with posterior semicircular canal BPPV
* Patients diagnosed with lateral-semicircular canal BPPV

Exclusion Criteria:

* Unable to understand and follow simple instructions (e.g. due to severe dementia, hearing loss or visual impairment)
* Persons temporarily or permanently living in a residential or psychiatric care centre, a home for the disabled or rehabilitation centre
* Persons with contra-indications for the diagnostic maneuver, vHIT or caloric irrigation test (e.g. severe limitation in mobility of the cervical spine of perforation of the tympanic membrane)
* Persons with other (acute) vestibular disorders and who as a result no longer meet the above mentioned diagnostic criteria for BPPV
* Persons with evolutionary disorders of the central nervous system (e.g. multiple sclerosis, Parkinson's disease, amyotrophic lateral sclerosis).
* Persons who are already taking antivertigo drugs.
* Persons still in the rehabilitation phase after an orthopedic or cardiovascular incident.
Cryoneurolysis for Cutaneous Neuropathic Pain

Feasibility study with 25 patients investigating the effect of cryoneurolysis on persistent cutaneous neuropathic pain after surgery and trauma. All patients receive active treatment (cryoneurolysis). The study design is unblinded, non-randomized, non-controlled.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 17 years
* ASA (American Society of Anesthesiologists) physical status classification system I-III
* Informed consent
* Capable of subjective evaluation of pain
* Capable of reading and understanding Danish and informed written consent
* Average pain intensity \>49/100 on VAS in the primary focal pain area for a minimum of 6 months at the time of inclusion
* Relevant injury (surgery or trauma) of peripheral nerves
* Plausible cutaneous location of pain
* In the area of pain, at least one of the following (1-8): (1) Hypo/anesthesia for touch/brush (2) Hypo/anesthesia for cold (3) Hypo/anesthesia for warmth (4) Hypo/anesthesia for pinprick (5) Allodynia for touch/brush (6) Allodynia for cold (7) Allodynia for warmth (8) Hyperalgesia for pinprick
* Neuropathic pain score (Douleur Neuropathique en 4 Questions, DN-4) \>3/10
* Definitive diagnosis of neuropathic pain (Finnerup et al 2016)

Exclusion Criteria:

* Inability to cooperate
* Inability to understand Danish
* Allergy to local anesthetic
* Infection in the area of cryo probe insertion
* Significant competitive chronic pain
* Progressive neurologic disease
* Increased risk at needle insertion and cold exposure (e.g. Raynaud, coagulopathies)
* Uncontrolled severe systemic disease
* Implanted electronic devices unless approved by the relevant medical specialist
* Previous cryoneurolysis with no relevant effect for the same neuropathic pain
* Previous interventional pain therapy (e.g. spinal cord stimulation) with no relevant effect for the same neuropathic pain
* Expected duration of life \< 2 years
* Pregnancy
* Abuse of alcohol, narcotics or medicine
* Current psychiatric disease
* Inclusion in other clinical trials
* Ongoing patient complaint
* Body mass index \< 18.5 or \> 34.9 kg/m2
* Change of pain therapy within the last 28 days prior to inclusion
Triple H ODC Trial

In an avalanche burial with an air pocket hypercapnia (and hypoxia) develops within few minutes, hypercapnia increases the rate of cooling and therefore the development of hypothermia. The Triple H Syndrome (Hypoxia, Hypercapnia, Hypothermia) occurs. This specific combination of the three parameters is unique for avalanche burial with an air pocket. Every single parameter has a substantial effect on the hemoglobin-oxygen dissociation curve, but until now no study described the combination of these three parameters. This curve will be measured under these specific conditions in a specifically developed in vitro model, to quantify its shifts and to show if there are combined effects of pCO2 and temperature. The newly developed method will be validated in comparison with an established method. The project will be performed with whole blood, drawn by healthy volunteers, in an experimental setting. The samples will be blinded to the investigator and analyzed in a randomized manner.

The ODC is a function of pO2 and SO2. pO2, the independent variable, is plotted on the x axis, SO2 on the y axis. For the determination of this function, a pairwise measurement of pO2 and the corresponding SO2 is to be performed. Using nonlinear regression analysis, the ODC can be fitted to the measured points that describe the relation of pO2 and SO2 and characteristic parameters like p50 value and inflection points can be calculated.

To measure the ODC under the conditions of the Triple H Syndrome (Hypoxie, Hypercapnia, Hypothermia), the temperature and the pCO2 have to be changed and controlled during the measurement. No commercially available instrument is able to obtain this. Therefore, we envisaged the development of an entirely new approach.

In the 3H ODC trial venous blood will be drawn from 18 - 40 years old female and male volunteers by a unique venipuncture. The participants have to be in a fasted situation, ASA I and nonsmokers. The blood sample will be immediately pseudonymized and stored on ice and a venous blood gas analysis will be carried out (pH, Hb, COHb, MetHb, FHb). Simultaneous to the main measurement, 2,3 BPG will be quantified by an ELISA test and any unknown hemoglobinopathy will be excluded by Hemoglobin Electrophoresis. In the 3H ODC trial 4 different pCO2 levels and 4 different temperatures will be analyzed in the resulting 16 combinations. In each round a lot of ODCs will be measured, the measurement chamber will be filled with participants blood samples in a randomized manner. After the measurements, the blood samples will be discarded.

Eligibility Criteria:
Inclusion Criteria:

* 18-40 years
* fasted situation
* ASA I
* Informed Consent

Exclusion Criteria:

* any drug abuse
* any drug intake within the last 10 days
* smoking
* known hemoglobinopathy
* relevant illness within last 14 days
* relevant blood loss within last 14 days
* pregnancy or breast-feeding
* participation in any pharmacological study
* exposure to high altitude (\> 3000 m) within last 4 weeks
Topical Metronidazole vs Control in Reducing Periodontal Pockets in a Split Mouth Clinical Trial

The effect of both the mechanical treatment and the topical metronidazol in reduccing the inflammation and depth of the periodontal pockets were assessed on the first bicuspids.


Eligibility Criteria:
Inclusion Criteria:

* Periodontal patients with all first premolars suffering from moderate periodontal pockets (\>4mm of probing depth)

Exclusion Criteria:

* No patients received antibiotics nor periodontal treatment in the previous 6 months
Effect of EPBD in ERCP on the Prognosis of Patients With Choledocholithiasis Complicated With Duodenal Papillary Diverticula

The investigators hypothesized that nipple balloon dilatation could make ERCP more successful and reduce postoperative complications and mortality. So the investigators design this experiment on this assumption.

The incidence of periampullary diverticula in patients with choledocholithiasis is very high at 47.1%. A large number of literatures refered that duodenal papillary diverticulum is a high risk factor for postoperative complications and recurrence of choledocholithiasis . Till now, there have been no randomized controlled trials to explore the effect of nipple balloon dilatation (EPLBD) on the treatment and prognosis of patients with choledocholithiasis complicated with periampullary diverticula (found during ERCP).

Eligibility Criteria:
Inclusion Criteria:

1. Patients with choledocholithiasis. 2. During ERCP, the patient was diagnosed as choledocholithiasis combined with duodenal papillary diverticulum. 3. Ages 16 to 75. 4. choledocholithiasis no larger than 1.5 cm

Exclusion Criteria:

1. Patients with duodenal papillary tumor. 2. Pregnant. 3. Patients with gastrointestinal duct obstruction endoscopy who cannot be operated and who have endoscopic contraindications. 4. Patients with duodenoscopy contraindications. 5. Patients with severe pancreatitis and other serious diseases.
Effect of 0.5% vs 0.375% Ropivacaine on Autonomous Nervous System

It is established that the local anesthetic that is administered during an interscalene block affects the autonomic outflow to the heart. This is very well seen during shoulder surgery when the patient is positioned in beach chair pasition.

The investigators want to study the different effect of the two concentrations (0.5% and 0.375%) of ropivacaine on the autonomic nervous system through blood pressure and heart rate measurements.


Eligibility Criteria:
Inclusion Criteria:

* Elective shoulder surgery
* Age 18- 80 years old
* ASA I - IV
* Beach chair position

Exclusion Criteria:

* Coagulopathy disorders
* Infection at the puncture site for the interscalene block
* Neurological deficit on the side to be operated
* Allergy to local anesthetics
* Psychiatric disorders
* Patient's refusal
* Problems with patient communication
* Failure of the interscalene block
Genetics of Wilms' Tumor and/or the Associated Conditions of Aniridia, Hemihypertrophy, and Genitourinary Anomalies

The goal of this clinical research study is to collect information and blood samples to try to learn why some people develop cancers and tumors, why some families have more cancers than others, and whether certain genes or regions of DNA (the genetic material of cells) affect a person's risk of getting cancer.

This is an investigational study.

Up to 1500 patients and family members will take part in this study. All will be enrolled at MD Anderson.

If you choose to take part in this study, blood (about 10 teaspoons) will be drawn for genetic testing. The blood may be drawn more than 1 time, depending on how much blood is drawn at the first visit, and if you are available for more blood draws. If this is the case, your doctor will discuss any extra blood draws with you.

For small children (less than 5 years old), about 2 teaspoons will be drawn. Children who are 5 years old or older will not have more than 3 teaspoons drawn.

You will complete a questionnaire about your medical history and family medical history. The questionnaire should take about 1 hour to complete. The study staff will also review your medical records.

You will be asked to allow the study staff to collect any of your tissue (whether healthy or cancerous) that is leftover from surgeries performed as part of your standard care. This may be from any past or future surgeries or any tissue being stored at MD Anderson or elsewhere. No new surgeries or biopsies will be performed for this study.

Before your information, tissue samples, and/or bodily fluids can be used for research, the people doing the research must get specific approval from the Institutional Review Board (IRB) of MD Anderson. The IRB is a committee made up of doctors, researchers, and members of the community. The IRB is responsible for protecting the participants involved in research studies and making sure all research is done in a safe and ethical manner. All research done at MD Anderson, including research involving your information, tissue samples, and/or bodily fluids, must first be approved by the IRB.

You may be contacted either by phone or mail 1 time a year, so that the study staff can update your medical history and information. If contacted by phone, this call should last about 30 minutes.

Eligibility Criteria:
Inclusion Criteria:

1. Patients with familial and sporadic Wilm's tumor, genitourinary anomalies, Beckwith-Wiedemann hemihypertrophy and/or aniridia, and family members of patients.

Exclusion Criteria:

1. Patients who do not meet inclusion eligibility criteria are excluded.