cyrilzakka/clinical-trials huggingface dataset:
Clinical Prognostic Study on Acupuncture Intervention for Traumatic Spinal Cord Injury

Patients with traumatic spinal cord injury were divided into acupuncture treatment rehabilitation group and conventional rehabilitation treatment group, with 42 people in each group. After treatment, their clinical efficacy was evaluated.

Patients with traumatic spinal cord injury were divided into acupuncture treatment rehabilitation group and conventional rehabilitation treatment group, with 42 people in each group. All patients were treated with conventional rehabilitation training. On this basis, the acupuncture treatment and rehabilitation group was given acupuncture and moxibustion treatment, and the acupuncture measures were mainly on the Dumai point. At the time of enrollment (before treatment), during treatment, after treatment, and 3 months of follow-up (3 months after the end of treatment), the main efficacy indicators were collected: spinal cord injury ASIA classification, motor function score, light touch function score, acupuncture sensory function score, improved Barthel daily activity index, and complications.

Eligibility Criteria:
Inclusion Criteria:

* There is a clear date of injury
* Clear location of damage
* The cause of injury is traumatic factors
* Agree to participate in this study

Exclusion Criteria:

* The time and location of the injury are unknown
* Disagree to participate in this study
* Patients with contraindications for acupuncture intervention (such as skin lesions or ▪Rashes at potential acupuncture intervention sites)
Q Fever and Auto-immunity

The IHU Mediterranean infection is national reference centre for Q fever. Coxiella burnetii is the bacteria responsible of this infection. The bacterium Coxiella burnetii infection is associated with secretion by the body both many antibodies against the bacteria but also against certain cells of the body (autoantibodies). These autoantibodies may have no effect or be associated with specific symptoms. Anti-Phospholipid antibodies are especially prevalent in the Q fever. Apart from this infection, they are associated with thrombocytopenia, obstetric complications, thrombosis and heart valve damage. These conditions have also been described as complications during Q fever. In a retrospective preliminary work on Q fever, we have shown that the presence of high levels of IgG anti-cardiolipin was associated with the presence of valvular and the evolution to endocarditis. Such associations have a therapeutic involvement and must therefore be confirmed. Indeed, if these associations were confirmed, a trans-esophageal ultrasound could be systematically proposed to patients with valvular disease of trans-thoracique ultrasound but IgG anticardiolipin high levels. Other special attention could be given to patients with high autoantibodies.


Eligibility Criteria:
Inclusion Criteria:

* Patients with a current or former Q fever diagnosis
* Patient \> or = 18 years old.
* Patient who does not declined to have his medical records reviewed for research.
* Patient with health insurance.

Exclusion Criteria:

* Minor patient (\<18 years )
* Adult patient under guardianship .
* Patient deprived of liberty or judgment.
* Patient refusing to sign the informed consent form .
Safety and Tolerability of hCBE-11 in Subjects With Advanced Solid Tumors

This is a Phase I, open-label, dose-escalation study on subjects with advanced solid tumors. This is the first study of hCBE-11 in humans and is designed to determine the safety and how well patients tolerate this investigational drug. The study duration is two years with treatment visits occurring weekly for either 4 or 8 weeks, follow-up for 8 weeks and long-term follow-up contact every 3 months thereafter.


Eligibility Criteria:
Inclusion Criteria:

* Relapsed or refractory solid tumors not curable with standard therapy.
* At least one measurable lesion
* ECOG Performance Status less than or equal to 2
* Acceptable hematologic status
* Albumin greater than or equal to 2.5 g/dL
* Normal calculated glomerular filtration rate (GFR)
* Acceptable liver function

Exclusion Criteria:

* Uncontrolled cardiac disease, angina, congestive heart failure, or myocardial infarction within 6 months prior to Study Day
* Known history of hepatitis B or C, or HIV infection
* Clinically significant effusions, including pericardial, pleural, and ascites
* Serious non-malignant disease
* Central nervous system (CNS) metastatic involvement except where the disease has been successfully treated
* Investigational therapies within 4 weeks of Study Day 1
* Radiation therapy of tumors to be followed for this study
* Chemotherapy, biologic therapy, or major surgery other than diagnostic within 4 weeks prior to Study Day 1
* Current Grade 3 or 4 neurological toxicity
* Concurrent anti-neoplastic therapy and/or steroids
Cognitive Behavioral Therapy for the Prevention of Paranoia in Adolescents at High Risk

The main objective of this study is to decrease the severity of symptoms and improve psycho-social functioning in youth at high risk of developing psychosis by providing a specialized Group-and-Family-based Cognitive Behavioral Therapy (GF-CBT).

24 adolescents and young adults between the ages of 12 and 25 who are at high risk of developing psychosis and exhibit paranoid ideation will be recruited to participate in a pilot randomized controlled trial. Subjects will be randomly assigned to the intervention (GF-CBT)or control (symptom monitoring) groups. GF-CBT is based on a cognitive neuropsychiatric model of delusions, and incorporates recent developments in learning and cognitive theories. GF-CBT consists of individual, group, and family group sessions. The three-part program teaches adolescents and family members Cognitive Behavioral skills that they can continue using on their own after completion of the program. Preliminary efficacy of the intervention will be evaluated using standardized measures by blind evaluators conducted at baseline, post-treatment, and post-termination follow-up over the next 2 years. Hypotheses: (a) GF-CBT will be associated with: high rate of remission from "at risk status" and low rates of transition to psychosis (defined by CAARMS criteria); greater improvements in severity of symptoms; and improved functioning; (b) decrease in family members'level of stress, and improved coping; (c) Family members will demonstrate proficiency in CBT Skills.

Eligibility Criteria:
Inclusion Criteria:

* meets criteria for ARMS (at Risk Mental State, assessed by CAARMS)
* Elevated suspiciousness (PANSS,P6≥3)

Exclusion Criteria:

A diagnosis of any of the following:

* Moderate to severe learning disability
* Substance dependence
* Organic impairment known to affect brain
Study on Immediate Loading of Immediately Placed Single Implants.

The purpose of this study is to evaluate survival and success rates of dental implants placed with immediate loading protocol in extraction sockets. All patients were monitored for 1 year after implants placement.

The international literature supported the potential advantages offered by this approach, but indicated a higher risk when compared with immediate loading in healed ridges.

The hypothesis to demonstrate is an high success and survival rates of Nobel Active™ implants used in combination with Bio-Oss® material.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* Single-tooth implant restorations in the aesthetic zone

Exclusion Criteria:

* Medical risk patient
* Smoking
Use of Integrated Pulmonary Index Monitorisation in Children Undergoing Botulinum Toxin Injection

This study aimed to detect hypoxia early with ıntegrated pulmonary index monitoring compared to saturation.

This trial will be held at the kocaeli Universty Hospital. 75 children 4-17 years of age undergoing botulinum toxin injection with sedation will be enrolled in this prospective study. Patients premedicated with midasolam iv 0.5 mg bolus and then sedated with propofol 1 mg/kg and fentanyl 0.5 mg/kg . Integrated pulmonary monitoring and noninvasive capnograhy will be used. Bis monitoring and spo2 monitoring will be applied. standard anesthesia monitoring including noninvasive blood pressure, spo2 , ekg and heart rate will be monitored. This trial aimed to detect hypoxia and apnea earlier than pulse oximetry.

Eligibility Criteria:
Inclusion Criteria:

* 4-16 age pediatrics
* undergoing botilinum injection with sedation
* asa 1-2

Exclusion Criteria:

* \> 18 age
* asa 3-4
* patients with upper respiratory tract infection
Misoprostol Administration Before Operative Hysteroscopy

The objective of this study is to compare the efficacy of oral, sublingual, vaginal, and no misoprostol prior to operative hysteroscopy in premenopausal women.

The route of administration of misoprostol for cervical dilatation prior to operative hysteroscopy can be oral, vaginal, or sublingual. However, it is still unclear which route is more effective and less harmful for cervical dilation prior to operative hysteroscopy in premenopausal women. Furthermore, there have been no studies comparing among oral, sublingual, and vaginal misoprostol, no medication (control) in these women. The objective of this study is to compare the efficacy and safety of oral, sublingual, vaginal, and no misoprostol prior to operative hysteroscopy in premenopausal women.

Eligibility Criteria:
Inclusion Criteria:

Symptomatic patients that were suspected as having intrauterine pathology, such as submucosal myoma, endometrial polyp or other endometrial pathological findings based on the transvaginal ultrasound, were enrolled.

Inclusion criteria were as follows: women who were of reproductive age (i.e., were premenopausal) and were not pregnant at the time of presentation (i.e., negative for urine pregnancy test or last menstrual period within the last 4 weeks). -

Exclusion Criteria:

Exclusion criteria included any evidence of a contraindication to prostaglandins (history of severe asthma, glaucoma, preexisting severe cardiac disease, or renal failure), or allergy to prostaglandins, any sign of genital infection, presence of significant uterovaginal prolapse that could affect administration of vaginal tablets, history of cervical surgery, presence of space occupying lesions in endocervical canal, and treatment of GnRH agonist.
Different Durations of Adjuvant Anastrozole Therapy After 2 to 3 Years Tamoxifen Therapy in Breast Cancer

The purpose of this study is to determine whether 6 years adjuvant anastrozole will improve the disease free survival compared to 3 years adjuvant anastrozole in postmenopausal hormone sensitive breast cancer patients, subsequent to 2-3 years tamoxifen


Eligibility Criteria:
Inclusion Criteria:

* postmenopausal patients with hormone receptor positive breast cancer who have already received 2 to 3 years of adjuvant tamoxifen, and who never had signs of loco-regional recurrences or distant metastasis

Exclusion Criteria:

* Previous hormonal therapy as adjuvant breast cancer treatment besides tamoxifen.
* Previous history of invasive breast cancer within the last 10 years, other then the breast cancer that is currently treated with tamoxifen
Comparison of Intraneural and Extraneural Young's Modulus Using Shear Wave Elastography

The investigators would like to compare the stiffness inside and outside nerves using a special type of ultrasound imaging called shear wave elastography. Shear wave elastography is a special form of ultrasound as the pictures taken are in colour. An ultrasound machine has different ways of taking pictures of inside the body: one is by measuring the brightness of different body parts (often referred to as the B-Mode scan), the pictures taken in this way are the same as those you may have seen of unborn babies inside their mum's tummies; another way is by measuring the stiffness of different body structures which is how shear wave elastography works. The investigators hope that this new technology will help doctors to see the parts of the body that are important to them.

Shear wave elastography is a quantitative ultrasound modality increasingly used to differentiate between "hard" breast cancer masses and "soft" normal tissue. Unlike strain elastography, shear wave elastography applies a non-compressive longitudinal acoustic radiation force to underlying tissues, inducing transverse shear waves. Studies in Thiel embalmed human cadavers have shown significant differences in Young's modulus between intraneural and extraneural tissue, and ready colour differentiation between tissues.

The investigators own pilot studies have shown a 3-fold greater Young's modulus within nerve in Thiel embalmed cadavers and human volunteers. The investigators hypothesis is that shear wave elastography can differentiate between nerve and adjacent tissue in patients before nerve block for surgery. If so, this technology has the potential to reduce the incidence of complications with UGRA and encourage parallel applications such as cancer node biopsy.

Eligibility Criteria:
Inclusion Criteria:

* All patients presenting for elective orthopaedic surgery \>16 years of age.
* ASA score 1, 2 or 3.
* Capacity to provide informed consent.

Exclusion Criteria:

* Patients not undergoing ultrasound guided regional anaesthesia.
* ASA score 4 or above.
* Patients without the capacity to provide informed consent.
* Pregnant women.
* Patients currently participating in another research project or patients who have participated in a research project in the 6 months
Parkinson's KinetiGraph, PKG in Patients With Deep Brain Stimulation and Continuous Levodopa Infusion Therapy

In this study the aim is to evaluate the outcome of deep brain stimulation (DBS) and continuous intraduodenal levodopa therapy in patients with advanced Parkinson' disease by using Parkinson's KinetiGraph™ device which is a movement and acceleration measuring device. In this study we also evaluate the usability of Parkinson's KinetiGraph™ device by comparing it with written patient diaries.

In this study the aim is to evaluate the outcome of deep brain stimulation (DBS) and continuous intraduodenal levodopa therapy in patients with advanced Parkinson' disease by using Parkinson's KinetiGraph™ logger (PKG) device which is a movement and acceleration measuring device.

A measurement is done before and after the implantation of selected therapy. PKG will measure automatically in every two minutes the movement of selected limb (usually the more affected upper extremity) for six days. At the same time a patient will keep a written diary of his/her Parkinsonian symptoms. Diary and collected PKG data will be compared. PKG will also remind with vibration the patient of the time drug administration and the patient can confirm this with pressing a button on PKG. The collected data will be transmitted to a computer and analyzed mathematically to produce a visual graph of daily movements. The aim is to evaluate PKG's usability in measuring Parkinsonian symptoms and in evaluation the outcome of DBS and levodopa therapy. Main parameters in evaluation are bradykinesia score and dyskinesia score.

Eligibility Criteria:
Inclusion Criteria:

* Patient with diagnosed Parkinson's disease
* Parkinson's disease is in advanced state (defined by the treating physician)
* A good response with over 30 % improvement of scores in Unified Parkinson's disease rating scale part III in pre-DBS evaluation

Exclusion Criteria:

* Age older than 70 years (this is a clinical exclusion criteria for DBS treatment)
* No history of psychosis or depression (this is a clinical exclusion criteria for DBS and intraduodenal levodopa therapy)
* No diagnosed dementia (this is a clinical exclusion criteria for DBS and intraduodenal levodopa therapy)
Efficacy of Yoga for Postpartum Depression

The aim of this project is to compare the efficacy of an 8-week yoga intervention, relative to a wait-list control (WLC) condition, for improving psychological functioning and health-related quality of life in depressed postpartum women. It was hypothesized that the yoga intervention would be significantly more efficacious than the wait-list control condition in reducing symptoms of depression and anxiety, and improving health-related quality of life, at the end of the 8-week yoga intervention.


Eligibility Criteria:
Inclusion Criteria:

* Score of 12 or greater on the 17-item Hamilton Depressing Rating Scale
* Participant must reside within a 30 mile radius of the yoga studios
* ≥ 6 weeks postpartum if delivery was either complicated and/or involved a cesarean section

Exclusion Criteria:

* Current or past diagnosis of bipolar disorder, schizophrenia or other psychotic disorder, alcohol or drug abuse/dependence (except nicotine), or anorexia in the past year
* Acute suicidal or homicidal risk
* Current mental health treatment, including psychotropic medications or psychotherapy with a certified therapist
* St. John's Wort or Fish oil
* Practiced yoga at a studio with a certified yoga instructor within the past month
* Significant medical disorder (e.g., seizure disorder) that is contraindicated for exercise in postpartum women
Follow-up Study of Autologous Cultured Adipose-derived Stem Cells for the Crohn's Fistula

This is an open follow-up clinical trials to evaluate a sustained efficacy and safety of Adipoplus inj. for 10 months (12 months after final dose injection)after Phase II clinical trial.


Eligibility Criteria:
Inclusion Criteria:

* the patients who have participated in ANTG-ASC-202 clinical trial
* the patients who have experienced with Adipoplus in ANTG-ASC-202 trials
* the patients who submit written consents and is able to obey requirements of trials

Exclusion Criteria:

* pregnant or breast feeding
* autoimmune disease other than Crohn's disease
* infectious diseases including HBV, HCV or HIV
* who is not willing to use effective contraceptive methods during the study.
* active tuberculosis
* moderate to severe active or worsened Crohn's disease
* who have received Infliximab during or after ANTG-ASC-202 trial
Electromagnetic Navigation During Ultrasound Guided Foam Sclerotherapy for Venous Malformations

The aim of this study is to evaluate the feasibility of assisted electromagnetic navigation in percutaneous echo-guided sclerotherapy of slow-flow vascular malformations. Feasibility will be defined in terms of the percentage of patients for whom the procedure is successful.

Primary interventional treatment of low flow vascular anomalies includes ultrasound guided foam sclerotherapy. Each procedure involves a percutaneous needle insertion. However, procedures remain complicated to obtain the right trajectory in order to inject the foam at the center of the abnormality. Electromagnetic navigation system tracks the operator's needle, meaning the position and progression of the needle is visualized in 3D real time on the ultrasound probe interface.

The present trial evaluate the feasibility of the electromagnetic navigation system during the needle insertion and the improvement of needle placement accuracy.

Eligibility Criteria:
Inclusion Criteria:

* Low Flow Vascular Abnormality diagnosed by Duplex Ultrasound and MRI
* Decision of Ultrasound Guided Percutaneous Foam Sclerotherapy taken in multidisciplinary staff meeting

Exclusion Criteria:

* patients with pacemakers or internal defibrillator
* patients with ferromagnetic implanted material
* patients who are wards of court or under guardianship
* patients deprived of freedom by judicial or administrative decision
* patients under legal protection
* pregnant women
Comparing the Effectiveness of Cyanoacrylate Tissue Adhesives and Conventional Sutures

This study compares the effectiveness of two materials used for intraoral wound closure after removal of impacted mandibular third molar tooth. One Group received braided black silk suture and the other group received N-butyl 2-octyl cyanoacrylate tissue adhesives.

Conventional method of wound closure after removal of impacted mandibular molar is by suturing the wound using braided black silk suture and allowing for primary healing. Suturing in the most posterior region of oral cavity is not easy, it requires more time and additional skills as well. Patient has to come for a second visit for removal of suture. Moreover tight sutures may lead to ischemia and necrosis.

Tissue adhesives adopts the idea of sutureless wound closure. They are even sloughed off from the surface of mucosa 7 days after the application.

This study compares the effectiveness of conventional sutures and tissue adhesives in closure of intraoral surgical wounds after removal of mandibular third molar.

Eligibility Criteria:
Inclusion Criteria:

* patients requiring surgical removal of mesioangular, position A impacted mandibular third molar
* clean incisions approximately 2-3 cms in length which can be approximated
* Healthy (ASAI) or patients with mild systemic disease no functional limitations
* Patients not allergic to the drugs or anesthetic agents used in the surgical protocol

Exclusion Criteria:

* Patients taking any medications that influences wound healing
* Patients on non steroidal anti inflammatory drugs
* smokers
* uncooperative patients patients allergic to cyanoacrylate
Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable?

The aim of this study is to compare the efficacy of a single dose of intramuscular dexamethasone versus 3 days of twice-daily oral prednisolone in the management of mild to moderate asthma exacerbations in children and test whether this single dose of intramuscular dexamethasone 0.6 mg/kg (max. 18 mg) is equal to prednisolone 1 mg/kg/day (max. 40 mg) in the treatment of exacerbations of asthma in children, as measured by the Pediatric Respiratory Assessment Measure (PRAM).

This study will be performed in Assiut university Children Hospital and will include patients with asthma exacerbations presented to the emergency department for three months. All children presenting to the emergency department with mild to moderate asthma exacerbations will be assessed to decide if the child needs treatment with salbutamol. Before starting treatment the Pediatric Respiratory Assessment Measure (PRAM), vital signs, and oxygen saturation will be recorded. Peak expiratory flow rate (PEFR) will also be recorded if the patient was 6 years or older.

Children with mild to moderate asthma exacerbation will be given the first dose of salbutamol and will be reassessed after 20 min by the emergency department attending. If further salbutamol is needed, subjects automatically will receive the second dose 20 min apart and receive either single dose of intramuscular dexamethasone (0.6 mg/kg to a maximum of 18 mg) or oral prednisolone for 3 days (1 mg/kg to a maximum of 40 mg), given orally .

A repeat physical examination will be performed, including oxygen saturation, vital signs, PRAM, PEFR after the 3rd dose of salbutamol and at the end of the third day to evaluate the effect of prednisolone and dexamethasone on the improvement of asthma scores. Patient compliance to prednisolone therapy for three days will be also recorded.

This study will be performed in Pediatric hospital - Assiut university and will include patients with asthma exacerbations presented to the emergency department for three months.

Eligibility Criteria:
Inclusion Criteria:

* Ages 2 to 16 years
* Background history of asthma
* Presentation with an asthma exacerbation requiring repeated salbutamol after 20 minutes.

Exclusion Criteria:

* Less than 2 years old or over 16 years
* Critical or life-threatening asthma
* Known tuberculosis exposure
* Active varicella or herpes simplex infection
* Documented concurrent infection with Respiratory syncytial virus
* Fever \>39.5°C
* Use of oral corticosteroids in the previous four weeks
* Concurrent stridor
* Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric