cyrilzakka/clinical-trials huggingface dataset:
Optimizing Prescribing Decisions for Hospitalized Older Adults With Chronic Conditions

The goal of this pilot clinical trial is to learn if providing a clinical decision framework for managing older adults chronic conditions during hospitalization to inpatient clinicians improves clinicians' ability to individualize chronic condition prescribing decisions for hospitalized older adults (65 and older). The main questions it aims to answer are:

* Will the clinical decision framework lead to clinicians having greater confidence to individualize discharge prescribing?
* Will clinicians using the framework discharge make fewer changes to hospitalized older adults with home diabetes and hypertension medications than they did prior to receiving the framework?
* Will older adult patients of participating clinicians will report fewer gaps in understanding of medication changes after the clinician is exposed to the framework?

Researchers will compare participating clinician survey responses and prescribing records from before and after an educational session presenting the clinical decision framework.

Participants will be asked to

* Attend a one-time educational session on the clinical decision framework
* Complete 2 electronic surveys, one before and one following the educational session.
* Agree for researchers to contact their patients, in order for patients to complete a one-time phone survey about changes made to home medications during hospitalization and quality of communication from the hospital team.


Eligibility Criteria:
Clinician Participants:

Inclusion Criteria:

1. Attending clinicians who practice on the general medicine or hospital medicine service at UPMC Presbyterian, UPMC Montefiore, UPMC Shadyside, UPMC Mercy, or UPMC Magee-Women's Hospital campuses.
2. Practicing on the general medicine or hospital medicine service. This population may include physicians with training in general internal medicine, hospital medicine, family practice, internal medicine subspecialities, as well as advance practice clinicians.

Exclusion Criteria:

1. Anticipating leaving current clinical position within next 3 months
2. Less than 4 weeks of inpatient attending service scheduled within 3 months of recruitment

Patient Participants:

Inclusion Criteria:

1. Adult aged 65 years or older who are hospitalized under the care of a participating clinician and discharged home.
2. Eligible patients must recieve at least one cardiometabolic medication change at hospital discharge (can include new medication starts, stops, or dose changes). Cardiometabolic medications include any class of antihypertensive, lipid lowering, anti-platelet, or glucose lowering medications regardless of indication for use.

Exclusion Criteria:

1. Incapacity for informed consent / unable to answer survey questions due to cognitive impairment
2. Enrolled in hospice care
Pentriox - Induction of Oxidative Stress

The purpose of the study is to investigate phenoxymethylpenicillin (the v-penicillin) and trimethoprim's possible induction of oxidative stress in human cells. The induction is examined by comparing changes in oxidative stress in the treatment group with the change in a placebo group. The study is a randomized-based placebo-controlled study. Each treatment group consists of 30 healthy male volunteers who consume either v-penicillins, trimethoprim or placebo over 7 days. The induction of oxidative stress is measured by 8-oxoguanosine and 8-oxodeoxoguanosine, isolated from urine. A t-test will be performed to compare drug treatment with placebo. The results will be published.


Eligibility Criteria:
Inclusion Criteria:

* Caucasian
* healthy men
* non-smoker
* 18-35 years
* BMI: 18-30

Exclusion Criteria:

* Smoker
* high blood pressure
* allergies towards any of the tested medicine
* galactose-intolerance
* abnormal lipid profile
* CRP \> 10
* Glucose/galactose-malabsorption
* Use of medications and herbal remedies that affect/are affected by v-penicillin and trimethoprim
* intake of narcotics 2 months prior to trial
* intake of supplements 1 month prior to trial
* bronchial asthma
* allergies
* heart deficiencies
* brady cardia
* kidney disease
* liver disease
* hypo-potassium
* phenylketonuria
Intradermal Needle Therapy for Major Depressive Disorder

Major depressive disorder (MDD) is a common mental disorder that affects patients' physical health and quality of life. Although traditional acupuncture therapy has certain advantages in improving MDD, there are still some limitations, such as being time-consuming and some people having a fear of acupuncture. Therefore, intradermal needle therapy will be chosen in the treatment of MDD in this study, which is more convenient, shallow needling, and gentle than traditional acupuncture therapy. The study is designed to investigate the therapeutic effect and safety of intradermal needles for MDD.

A total of 120 participants with MDD who meet the inclusion criteria will be included in the study. Participants will be randomly divided into the SSRIs + acupuncture group, acupuncture + placebo group, and SSRIs + sham acupuncture group. This study will evaluate the efficacy and safety of the intradermal needle for MDD and investigate whether the intradermal needle reduces side effects and increases the efficacy of selective serotonin reuptake inhibitors (SSRIs) antidepressants for MDD. Furthermore, the study will demonstrate whether the intradermal needle has a synergistic effect with SSRIs on the treatment of MDD.

Eligibility Criteria:
Inclusion Criteria:

* 1. Patients should meet the diagnostic criteria of the International Classification of Diseases 10th Edition (ICD-10) diagnostic criteria for depression and are evaluated as moderate or severe MDD according to the severity of depression; 2. 12 ≤ age ≤60, male or female; 3. Participants have clear consciousness and could communicate with others normally; 4. Participants could understand the full study protocol and have high adherence. Written informed consent is signed by themselves or their lineal kin (for minor participants, their guardian should sign the informed consent form for them).

Exclusion Criteria:

* 1. Participants with serious primary diseases of cardiovascular, respiratory, digestive, urinary, hematological, endocrine, neurological disease, and other serious primary diseases, and the disease cannot be effectively controlled clinically; 2. Major depressive disorders caused by organic mental disorders, schizophrenia, bipolar disorder, psychoactive substances, and non-addictive substances; 3. Participants with suicidal tendencies; 4. Pregnant or lactating participants; 5. Participants taking other antidepressants that were not SSRIs or the pharmacological effects of such antidepressants have not been cleared; 6. Participants with intellectual disabilities who cannot cooperate with the questionnaire survey; 7. Participants with bleeding tendency, skin disease, allergic constitution, and allergic to adhesive tape; 8. Participants are participating in other trials.
Pseudoexfoliation and Chronic Kidney Disease

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.


Eligibility Criteria:
Inclusion Criteria:

* All patients with chronic kidney disease stage 1-5

Exclusion Criteria:

* History of eye trauma or surgery
Primary Debulking Surgery Including Bowel Resection in Advanced Stage Ovarian Cancer Using Caiman® Technology

Longitudinal prospective study on primary debulking surgery including bowel resection in advanced stage ovarian cancer patients using Caiman® technology

Using CAIMAN® technology in primary surgery for advanced ovarian cancer including bowel resections.

Analyze potential time-sparing and the incidence of post-surgical complications.

Prospective, longitudinal, observational. 40 patients / year.

Eligibility Criteria:
Inclusion Criteria:

* Age ≤ 75 years
* Patients with advanced ovarian cancer (FIGO stage IIIC-IV).
* Bowel resection
* Class 0-2 according to the American Society of Anesthesiologists (i.e.: ASA score ≤ 2)
* Written informed consent to the study

Exclusion Criteria:

* Pregnant or chronic infections
* Previous pelvic radiotherapy
Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease

The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety and efficacy of TMS.

The investigators compiled demographic, clinical, and neurocognitive data on all patients who had received TMS for any reason in the clinic over a 12-year period. Of 236 patients receiving TMS, 59 patients with AD and 14 with MCI satisfied study criteria and were compared to controls from the National Alzheimer's Coordinating Center (NACC). Neurocognitive outcomes were compared between magnetic resonance imaging (MRI) and electroencephalogram (EEG)-grid guided TMS in patients. Tolerability data was reviewed for all patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for possible or probable Alzheimer's disease.
* Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for mild cognitive impairment.
* Patients must have undergone at least two standardized neurocognitive batteries before and after beginning TMS.
* Patients must have received greater than or equal to five (5) TMS sessions in less than one year.

Exclusion Criteria:

• Patients with dementias from other causes, such as Lewy Body disease.
Determinants of Cognitive Impairment Among Geriatrics

This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.

Elderly patients (≥ 60 years of age) are enrolled in this study. The inclusion criteria are patients which have consented to take part in the study.

Data such as age, ethnic, education, BMI, waist and hip circumference, blood pressure, hearing impairment, vision impairment, depression, sleep disorder, mobility, hemoglobin levels, glycemic and lipid profile, as well as comorbidities and drugs used were collected from the patients' medical records, laboratory tests and through examination by trained examiners.

Cognition was determined through a combination of several psychiatric examinations using validated instruments namely - MiniCog, Clock Drawing Test, Three Word Recall, Alzheimer's Disease-8 Indonesia (AD-8 INA) Questionnaire and Short Portable Mental Status Questionnaire (SPMSQ).

Eligibility Criteria:
Inclusion Criteria:

* Must be classified as geriatric according to Indonesian Laws (≥ 60 years of age).
* Consented to participate in this study.

Exclusion Criteria:

* Uncooperative.
* Incomplete records.
Efficacy and Safety of Ondansetron Versus Metaclopromide Treatment in Infants With Gastro Oesophageal Reflux

This study aimed to fill the gaps by comparing the efficacy and safety of ondansetron versus metoclopramide for the control of gastroesophageal reflux disorder in children 1-12 months of age, presenting at the outdoor department of Allama Iqbal Teaching Hospital, Dera Ghazi Khan.

Since the FDA issued a warning against domperidone as a potential proarrhythmic drug in children, its use has been widely discouraged and no longer recommended in safe practices. This warning at one end persuaded the pediatricians to search for the new options; on the other end, the use of metoclopramide, H2 receptor antagonists, and alginate-based medications became superfluous, opening a wide area of research in search of the next potential best option. The findings of this study would add to the existing statistics and help clinicians to have better outcomes among infants with gastroesophageal reflux disorder.

Eligibility Criteria:
Inclusion Criteria:

* Infants of any gender
* Aged 1-12 months
* Presenting with symptoms of gastroesophageal reflux disease not responding to dietary modifications and positioning
* Afebrile at the time of presentation
* Vitally stable

Exclusion Criteria:

* No evidence of hypertrophic pyloric stenosis on ultrasonography
* Children with congenital heart disease
* Any history of prior illness associated with symptoms
* With abdominal distension
* Neurological impairment, like developmentally delayed, grossly microcephalic
New Score for Pseudo- Acanthosis Nigricans

Each side of the neck pseudo acanthosis nigricans was randomized in to either receiving glycolic acid peel or saline. Evaluation was done at baseline and after 3 sessions 2 weeks apart by percentage involvement and by ANASI score


Eligibility Criteria:
Inclusion Criteria:

* mild to moderate severity
* age \> 18 years old

Exclusion Criteria:

* Pregnant and lactating patients,
* patients with systemic diseases as connective tissue disease, diabetes,
* skin infection
* use of immunosuppressive drugs
* Susceptibility for post peel hazards as hyperpigmentation
* scarring and keloidal tendency
The Effect of Anesthesia on Pain in Percutaneous Nephrolithotomy

It is aimed to determine the ideal application by determining the effect of different anesthesia methods applied in percutaneous nephrolithotomy surgeries on analgesic consumption and pain level.

Different anesthesia methods are used in percutaneous nephrolithotomy.In addition to traditional analgesia methods such as intravenous paracetamol, NSAIDs, opioids, various methods such as epidiural analgesia or blocks added to general anesthesia are used.In this study, it was aimed to investigate whether central or peripheral block applications are preferred in percutaneous nephrolithotomy, and the need for intraoperative and postoperative analgesics in patients.In addition, it was aimed to investigate whether there was a change in analgesic consumption, recovery and pain level, and hospital stay in patients who were given general anesthesia or regional anesthesia, in a multicentric observational manner.

Eligibility Criteria:
Inclusion Criteria:

* patient giving consent
* accessing patient information

Exclusion Criteria:

* missing information in the patient file
Study of an Essential Oil and a Delmopinol Mouthrinse Effect on Dental Plaque Accumulation Index, Gingivitis Index and on Streptococcus Mutans, Lactobacillus, Aerobic and Anaerobic Oral Bacteria Colony Counts.

The use of mouthrinses may be of relevance as a complement to daily dental hygiene procedures, especially for patients who do not comply with a proper mechanical removal of dental plaque. Essential oils and delmopinol mouthrinses are effective to reduce dental plaque accumulation and gingivitis. Also an effect on dental bacteria can be found. The study hypothesis states that there are no differences between the mouthrinses on the reduction of gingivitis and dental plaque accumulation as well on the bacterial counts of Streptococcus mutans, Lactobacillus, aerobic and anaerobic bacteria.


Eligibility Criteria:
Inclusion Criteria:

* Patient at the dental hygiene clinic of Faculdade de Medicina Dentária
* Signature of consent form
* Have, at least, two quadrant with 6 teeth each
* Gingival Index at baseline less than 3
* Presence of dental plaque

Exclusion Criteria:

* Use of a mouthrinse
* Dental Hygiene appointment in the past 6 months
* Use of antibiotics in teh past 3 months
* Presence of extensive caries and fractures of teeth
Review of Diagnostic Yield of MRI Brain Results in Children Under Age 3 Years

The investigators aim to identify the frequency with which an elective brain MRI yields and etiologic diagnosis to explain its indication. The protocol includes children undergoing elective brain MRI with anesthesia prior to their third birthday.

On December 14, 2016 the FDA issued a warning regarding elective anesthetics in children under three years of age. While a single, short exposure to general anesthesia may not have negative effects on behavior or learning, repeated or prolonged anesthetics may affect brain development. To that end, minimizing exposure to elective general anesthetics if procedures are not clearly indicated in young children appeals to reason.

Eligibility Criteria:
Inclusion Criteria:

* Male or female aged 0-36 months who received anesthesia (volatile gas anesthesia) or IV sedation (propofol, dexmedetomidine, barbiturates, benzodiazepines, or other agents) for brain MRI

Exclusion Criteria:

* MRI without sedation, brain MRI plus additional MRI imaging, i.e. spine, heart, etc., sedated MRI by a member of other department besides Anesthesiology.
PICC-ports Versus Chest - Ports for Long Term Chemotherapy Deliverance in Oncology Patients

Central venous access devices are extensively used in oncology patients. The current standard is represented by devices inserted by direct ultrasound guided cannulation of deep veins of supra/infraclavicular area with a reservoir placed in a subcutaneous pocket of the upper chest wall ("chest-ports"). More recently, PICC (Peripherally Inserted Central Catheters)-ports have been proposed as an alternative to chest-ports.

Aim of this study is to demonstrate the non-inferiority of PICC ports compared to thoracic ports in terms of efficacy and safety.

Central venous access devices are extensively used in oncology patients who need safe deliverance of chemotherapeutic agents and drugs, transfusion of blood and blood products, and performance of laboratory tests, in solid as well as hematologic malignancies. These devices are mostly inserted by direct ultrasound guided cannulation of deep veins of supra/infraclavicular area and the reservoir is placed in a subcutaneous pocket of the upper chest wall ("chest-ports"). More recently, PICC (Peripherally Inserted Central Catheters)-ports have been proposed as a safe and effective alternative to chest-ports, claiming lower invasiveness, easier insertion and better patients' compliance. In PICC-ports a small reservoir is placed in a subcutaneous pocket located in the mid-third of the upper arm.

Since these feelings are currently based only on limited retrospective studies, aim of this randomized multicenter trial is to demonstrate the non-inferiority of PICC ports (experimental arm) compared to thoracic ports (control arm, as the current reference standard) in terms of efficacy and safety.

Eligibility Criteria:
Inclusion Criteria:

* ≥ 18 Age ≤ 75 yrs
* Histologic diagnosis of a solid tumour
* Need for intravenous , long term (\> 3 months), intermittent chemotherapy (either adjuvant or palliative)
* Eastern Cooperative Oncology Group (ECOG) Performance Status: 0-2

Exclusion Criteria:

* Active infections
* Coagulopathy, defined as platelet count \< 50,000/μL and/or Prothrombin time (PT)/International Normalized Ratio (INR) \> 1.5
* Chronic severe renal failure, stage 3b-4-5 or imminent need for a dialysis fistula
* Any conditions contraindicating chemotherapy treatments, as valued by treating oncologist
* Life expectancy \< 6 months, as valued by treating oncologist
* Inability to give an informed consent and/or history of psychiatric or addictive disorder or other medical condition that, in the opinion of the investigator, would preclude the patient from meeting the trial requirements
Ketamine on Acute Pain in Females and Males

The purpose of the study is to determine whether equal subanesthetic doses of racemic ketamine is equally effective on females and males after surgical removal of third molars

Ketamine is assumed to be a NMDA receptor antagonist which provides analgesia from acute postoperative pain(and other types of pain) subanesthetic doses. Gender differences in ketamine analgesia are not known. This placebo-controlled,randomised, parallel group study investigates the analgesic dose-response effect of ketamine in subanesthetic doses in female and male patients following surgical removal of third molars.

Comparisons: Placebo and ketamine in females and males.

Eligibility Criteria:
Inclusion Criteria:

* Indication for removal of third molar
* Between 20 and 30 years of age
* ASA Class 1

Exclusion Criteria:

* Psychiatric family (father/mother) or own anamnestic history
* Hypersensitivity towards NSAIDS or other rescue analgesics
* Verified or suspected pregnancy
* Lactating females
* Surgery lasting over 60 min
Single Session Intervention to Prevent Common Mental Disorders and Among College Students

The present study aims to determine the effect of presenting psychoeducation emphasizing "growth-mindset," and information on depression and anxiety symptom severity. The investigators hypothesize that psychoeducation emphasizing that mental health is malleable will increase the participant's engagement with risk factors outlined in the intervention

Depression and anxiety disorders (or common mental disorders; CMDs) are increasingly common among college students, with rates comparable to the general population. As such, brief, scalable and transdiagnostic prevention efforts targeting CMDs are needed. In order to address this need, this study aims to evaluate the impact of a single session intervention (SSI) utilizing growth mindset (GM) on CMD symptom severity and investigate the mediating role of changes in modifiable risk factors in the relationship between intervention and CMD symptom reduction. The intervention will adapt existing GM interventions for college students to engage mechanisms in the prevention and management of common mental disorders including engagement in modifiable risk factors. College students will be randomly assigned to complete either a GM intervention or a psychoeducation control.

Eligibility Criteria:
Inclusion Criteria:

* Age 17-26
* College student at the University of Nevada, Reno

Exclusion Criteria:

* Under the age of 17, over the age of 26
* Participated in pilot study
* Not a college student at the University of Nevada, Reno