cyrilzakka/clinical-trials huggingface dataset:
CMC Arthritis - Neoprene Vs. Thermoplast Short Opponens Splinting

Carpometacarpal Thumb Arthritis is a disease caused by different factors and attacks mainly woman older than 50 years. The signs and symptoms consist in pain, swelling, joint instability, deformity and loss of motion. Some evidence has shown that splinting of the thumb may be of benefit. There are two methods of splinting: The first is Standard Neoprene wrap-on thumb support (in which the finger is kept in the same position with in a standard Neoprene thumb splint). The second is Thermoplast Short Opponens splint (This splint is custom-made and the thumb is use as a template to design the splint). The purpose of this study is to test and evaluate these two protocols of splinting and assess which one helps or works better in patients with thumb arthritis.

Osteoarthritis of the thumb carpometacarpal joint is a common condition that affects approximately 16% to 25% of postmenopausal woman and causes pain, swelling, instability, deformity and loss of motion. This condition has been staged in 4 periods according to the degree of severity. Mild stages or stages 1 and 2 are usually treated conservatively by stabilization of the joint, which can be aggressively achieved by surgical ligament reconstruction or conservatively with thumb splints. Splinting is a typical treatment for osteoarthritis of the thumb with the goals of managing pain, stabilizing the CMC joint, and improving overall thumb function. There are limited studies showing the effectiveness of splinting for this condition indicating they are successful in decreasing pain and improving function in activities of daily living as well as radiographically improving joint stability. What is less clear is, once patients leave the clinic setting, how compliant they are with their splinting regimen. Patients with chronic illnesses tend to have compliance issues when it comes to their care. Also, there are limited studies comparing different modalities of splinting. A recent study compared custom-made short opponens thermoplastic splint with the metacarpo-phalangeal (MP) joint free to a pre-fabricated short neoprene splint. They found that patients preferred the neoprene splint but both splints provided some degree of pain relief, reduction of subluxation of the MP joint and improvement in function. Our purpose is to objectively quantify the various benefits of splinting for patients with thumb arthritis using the DASH score and assess if there is a difference between the pre-fabricated neoprene splint and the custom-made short opponens thermoplastic splint with the MP included.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 or older.
* Males and females diagnosed using clinical criteria as having CMC Thumb Arthritis
* Radiological diagnosis is not necessary

Exclusion Criteria:

- Patients with previous history of CMC Thumb Arthritis treated surgically
Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia

The purpose of this study is to investigate the maternal cardiac output response to rescue norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.

Preeclampsia, which affects 5% to 7% of parturients, is a significant cause of maternal and neonatal morbidity and mortality. Because of constricted myometrial spiral arteries with exaggerated vasomotor responsiveness, though blood pressure in parturients with preeclampsia are apparently higher than healthy parturients, placental hypoperfusion is more common. Spinal anesthesia is still the preferred mode of anesthesia in parturients with preeclampsia for cesarean section. In preeclampsia parturients, spinal anesthesia improve intervillous blood flow (provided that hypotension is avoided) which contribute to increase placental perfusion. Even so, 17-26% parturients with preeclampsia experienced postspinal anesthesia hypotension due to the extensive sympathetic block that occurred with spinal anesthesia. As a potential substitute drug for phenylephrine and ephedrine, norepinephrine has gained traction for use in parturients undergoing cesarean section. However, hemodynamic effects of the rescue norepinephrine bolus is still unknown. The purpose of this study is to investigate the maternal cardiac output response to rescue norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.

Eligibility Criteria:
Inclusion Criteria:

* 18-45 years
* Primipara or multipara
* Singleton pregnancy ≥32 weeks
* American Society of Anesthesiologists physical status classification II to III
* Scheduled for cesarean section under spinal anesthesia

Exclusion Criteria:

* Baseline blood pressure ≥180 mmHg
* Body height \< 150 cm
* Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2
* Eclampsia or chronic hypertension
* Hemoglobin \< 7g/dl
* Fetal distress, or known fetal developmental anomaly
ADME Study of [14C]ICP-022 in Healthy Males

The purpose of this study is to investigate the absorption, the metabolic pathways and the excretion of ICP-022 in healthy male adult participants after administration of a single oral dose of 150 mg of 14C ICP-022.


Eligibility Criteria:
key Inclusion criteria:

1. Weight: Body mass index (BMI) is 19\~26 kg/m2
2. signing of informed consent
3. Volunteers are able to communicate well with the investigators and be able to complete the trial according to the process

Key Exclusion Criteria:

1. physical examination, vital signs, routine laboratory tests (blood routine, blood biochemistry, blood coagulation routine, urine routine, stool routine + occult blood, serum amylase, thyroid function, etc.), 12-lead ECG, Chest X-ray (Anteroposterior), abdominal B-ultrasound (hepatobiliary, pancreas, spleen and kidney) and other abnormalities and clinical significance.
2. ophthalmologic examination shows abnormality and clinical significance
3. Positive test for hepatitis B (surface antigens HBs), or C (antibody HCs), positive test for HIV, positive test for Syphilis antibody.
4. Within 1 month before the screening, having not limited to known as hepatic enzyme inducers, inhibitors or substrates; (eg, inducer - barbiturate, carbamazepine, phenytoin, rifampicin, dexamethasone, rifabutin, rifapentine; inhibitors - SSRI antidepressants, cimetidine, diltiazem, macrolides, verapamil, imidazole antifungals) ;
5. Within 1 month before the screening, receiving the anticoagulant therapy such as warfarin or thrombin inhibitor and/or aspirin antiplatelet therapy

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Outcomes in Emergency Laparotomies During COVID-19 Pandemic

NLR has previously been observed to correlate with complications in upper GI (1) and colorectal (2) surgery. The investigators sought to assess if a similar correlation can be identified in emergency general surgical patients and if the presence of suspected or confirmed COVID-19 may impact on this.

Given the heterogeneity of emergency general surgery the investigators therefore plan to perform a retrospective review of patients having emergency laparotomies only at a single NHS site during COVID-19 pandemic. Assessment of outcomes and Neutrophil:lymphocyte ratio as a predictor of outcomes will be completed. Outcomes will be completed in line with the recent COVIDSurg study criteria (3). The primary outcome is 30-day mortality. Secondary outcomes are 7-day mortality, re-operation, length of stay, post-operative respiratory failure, post-operative ARDS (Acute Respiratory Distress Syndrome), post-operative sepsis and ITU (Intensive Therapy Unit)/HDU (High Dependency Unit) admission.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing emergency laparotomy (change made due to heterogeneity of emergency general surgery)

Exclusion Criteria:

* Inherited or acquired immunodeficiency (which may directly skew NLR)
Use of an Educational Video to Improve Adherence to Treatment in Voiding Dysfunction

This study aims to see whether an educational video on a common urinary dysfunction leads to improved parent and child perceived adherence to treatments recommendations.

This study aims to explore whether the use of an educational video on voiding dysfunction, a common urinary dysfunction, leads to improve parents and child perceived adherence to behavioral treatment recommendations. Our main hypothesis explores whether there is improved perceived adherence, and whether this improved perceived adherence leads to better symptom outcomes in this condition.

Eligibility Criteria:
Inclusion Criteria:

* Parents and Caregivers of pediatric urology patients with a diagnosis of Dysfunctional voiding (minimum 100 participants)
* 5-18 years old, no younger than 5 and no older than 18 years old
* Potty-trained - fully independent with toileting, can complete every step of the process and can do so satisfactorily by themselves.

Exclusion Criteria:

* Children with Voiding dysfunctionDysfunctional voiders with medically complex conditions (neurogenic bladder, POTS, EDS, etc.)
* Parent's child is notNot a first-time patient (i.e. has been seen in the past for dysfunctional voiding)
* Child has severeSevere intellectual disability, developmental delay, or cognitive impairment.
To Improve the Rate of Mother's Own Milk Feeding of Premature Infants in NICU

Thirteen hospitals in China will participate in the study, which objectives of this study is to improve the rate of mother's own milk feeding of premature infants in neonatal intensive care unit(NICU), evaluate the effectiveness of improving the quality of breastfeeding in clinical use ,form standardized process and improve clinical medical quality of premature infants.

In this study, the cluster randomized controlled matching design was used. Considering that evidence-based practice for improving quality(EPIQ) method is not only to improve the quality of individual, but also to improve the quality of breast-feeding of the whole neonatal intensive care unit(NICU), so a hospital was chosen as a cluster. The supervision unit is used for the quality control , coordination and technical support in the whole study process.The two NICU with similar number of premature infants, the same scale of NICU and little difference in the recognition of breast-feeding quality improvement measures that meet the inclusion criteria are taken as the a floor, and then randomly divided into two groups, taking the NICU as intervention group or the control group can avoid the individual influence of the intervention. In this study, recruited 12 NICUs. The purpose of study is to to increase the consumption of mother's own milk of premature infants through the existing measures of improving the breastfeeding quality, and then to improve the quality of life of the premature infant, and to further evaluate whether this model of improving the breastfeeding quality can be promoted in other NICU.

Eligibility Criteria:
Inclusion Criteria:

* Weight less than 1500g or gestational age less than 32 weeks;
* Admission to NICU.

Exclusion Criteria:

* Pregnancy with serious diseases, infectious diseases or other medical contraindications for breast-feeding (such as galactosemia);
* infants did not survive were excluded.
Positron Emission Tomography(PET) in Lymphoma Assessment

This study examines the role of a diagnostic test called Positron Emission Tomography (PET) scanning in patients with malignant lymphoma. The primary goal of this study is to find out how well PET scanning can detect malignant (cancerous) lymphoma, and how often this extra information will result in a change of stage of disease, or will result in a change in treatment management plans of patients with lymphoma.

It is currently unknown whether modifying treatment based on FDG-PET results is appropriate. However, clinicians are increasingly using the FDG-PET result, where obtained, in deciding management. Consequently, it would be premature to mandate PET-based treatment modifications in this protocol. Patients will be treated with existing protocols at the discretion of their treating oncologists, based on available information. Oncologists will be surveyed as to whether FDG-PET scan results could have (or affect patient management, and the intervention will be recorded).

Eligibility Criteria:
Group A: Newly Diagnosed

Inclusion Criteria:

* Patients \> 18 years of age.
* Confirmed diagnosis of HL or NHL (any histology).
* Any Ann Arbor stage.
* Pre-treatment staging including CT of head and neck, chest, abdomen and pelvis, where there is a minimum one equivocal finding on the scan, affecting the assignment of stage or IPI factor (i.e. stage III/IV vs. stage I/II, or a question of extranodal involvement by disease).

Group B: Response Assessment

Inclusion Criteria:

* Patients \> 18 years of age.
* Confirmed diagnosis of HL or NHL (any histology).
* Any Ann Arbor stage.
* Pre-treatment staging including CT neck, chest, abdomen and pelvis. If alternate assessment of the neck done by clinical palpitation, ultrasound, or MRI is negative, CT neck is not mandatory.
* Post-treatment staging including CT of head and neck, chest, abdomen and pelvis, at 1 - 6 weeks post-therapy.
* Treated with anthracycline-based chemotherapy, with or without radiation therapy (based on the stage of the disease). For Stage III/IV patients, PET will be done following completion of primary chemotherapy. For stage I/II patients, PET will be done after combined modality therapy, or after chemotherapy alone if this was the primary intention of therapy.
* Patients with residual mass on CT following primary chemotherapy with either "unconfirmed" CR (\>75% decrease in size) or PR (³50% decrease in size), based on International workshop criteria.

Exclusion Criteria: Response Assessment

* None Curative treatment Intent
* After initial therapy the response status is: complete response, stable disease, or progressive disease
The Effect of Playing Video Game on Intubation Skill

Video games are activities that require actively hand-eye coordination and where 3D thinking is at the forefront.

During the teaching of both laparoscopic surgery and robotic surgery techniques, it was revealed by the studies that the participants who played video games completed the trainings more easily and the success rate increased.

In a study comparing fiberoptic intubation success, anesthesia assistants playing video games had higher successful intubation rates and shorter intubation times in the first attempt.

Video stylets are newly developed devices that allow the use of video technology in airway management.

It has a camera at the end and a monitor to which the image is transferred. By transferring the real-time view of the airway structures, tracheal intubation increases the success rate and shortens the intubation time.

In order to determine whether video game playing has positive effects on videostylet use,ıt was aimed to compare the performances of the assistants who did play with the video game assistants.

Anesthesiology assistants will be questioned about whether participants have played video games before or not.

Participants will be divided into two different groups as those with and without prior video game experience.

Video game will be played for those who have previous experience for 5 days via 0.5 hour mobile phone (Pubg mobile).No games will be played on the other group.

Then, all participants will be trained on the video stylet.

Within the scope of this training, all participants will watch videos about 1-Video stylet application.

2-Verbal explanation will be made by the responsible and investigators of the study 3- All participants will practice on the model first

4-Responsible investigators will practice and show on the real patient.

5-Then all participants will perform the application on the real patient under the supervision of responsible and investigators.

Tracheal intubation time, success rate, number of interventions will be recorded by responsible and investigators.

Eligibility Criteria:
Inclusion Criteria:

* Mallampati score I-II
* Cormack-Lehane score I-II
* ASA physical status I-II
* who required endotracheal intubation for elective surgery

Exclusion Criteria:

* Pregnancy
* Mallampati score III-IV
* Cormack-Lehane score III-IV
* ASA physical score III-IV
* sternomental distance \< 12.5 cm
* mandibular-hyoid distance \< 6 cm
Comparison of Amoxicillin and Amoxicillin + Clavulanic Acid in Treating Acute Otitis Media in Children

This study aims to compare the effectiveness of two treatments for children with acute otitis media (middle ear infection). The two treatments being compared are amoxicillin alone and a combination of amoxicillin plus clavulanic acid. The study will help determine which treatment works better in helping children recover faster and reduce the risk of treatment failure or recurrence. By providing clearer evidence, the research aims to guide better treatment choices for children suffering from this common infection.

This study will evaluate the effectiveness of two antibiotic treatments in children diagnosed with acute otitis media, a common ear infection. The two treatments being compared are amoxicillin alone and a combination of amoxicillin and clavulanic acid. Acute otitis media is a significant health concern in children, causing pain, fever, and possible hearing loss.

The study will be conducted as a randomized controlled trial at the Department of Pediatric Medicine, Nishtar Hospital, Multan. A total of 162 children, aged 1 to 5 years, will be enrolled in the study. They will be randomly assigned to one of two treatment groups: one group will receive amoxicillin, and the other group will receive amoxicillin plus clavulanic acid. The children will be monitored throughout their treatment to assess how quickly their symptoms resolve, whether they experience treatment failure or recurrence, and if they develop any side effects.

The study aims to provide clearer evidence on the efficacy of the combination treatment (amoxicillin + clavulanic acid) compared to amoxicillin alone. By analyzing treatment outcomes such as symptom resolution time, side effects, and recurrence, the study will help inform clinical decisions and improve treatment protocols for acute otitis media in pediatric patients. The data will be analyzed using statistical software to determine whether the combination therapy leads to faster recovery and fewer complications. The findings from this study will contribute to better management of upper respiratory infections in children.

Eligibility Criteria:
Inclusion Criteria:

* Children aged 1 to 5 years
* Diagnosed with acute otitis media (as per operational definition)
* Both male and female participants
* Parental consent obtained

Exclusion Criteria:

* Children with allergies or contraindications to the trial drugs (amoxicillin or amoxicillin + clavulanic acid)
* Children with asthma or chronic obstructive pulmonary disease (COPD) (as per medical record)
* Children who have received treatment with the trial drugs within the past month
* Children already enrolled in other research programs or who have received trial treatment
* Children with any comorbid conditions that may interfere with the study
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.

To date, no pharmacological agents are proven efficacious in treating perioperative AKI. There is a strong biological rationale for the administration of amino acid in the management of patients at risk of AKI with increases in renal blood flow and GFR of 25 to 60% for several hours after the administration of amino acids (Woods LL 1993) mediated by a afferent arteriolar dilation.(Meyer TW 1983) Moreover, animal models have demonstrated that an increase in renal blood flow in response to a short-term amino acid infusion can protect the kidney from acute ischemic insults. Finally, these nephro-protective effects are preserved in critical illness. Cardiac surgery appears to be the best setting to test the likely beneficial renal effects of amino acid because of pathophysiological principles and the ability to intervene before the injury has begun. Although the etiology of AKI in cardiac surgery is multifactorial, renal hypoperfusion is believed to play a major role in this development by decreasing renal perfusion through a reduction in renal blood flow and through the activation of the sympathetic nervous system and the renin-angiotensin system with afferent arteriolar vasoconstriction. In this setting, a global increase in renal blood flow by means of Amino Acid therapy appears a logical and promising intervention.

The primary aim of the study is to determine whether providing continuous infusion of a balanced mixture of amino acids, compared to placebo (balanced crystalloid solution), reduces the incidence of acute kidney injury (AKI) in patients scheduled for cardiac surgery defined as KDIGO stage 1 or greater during hospital stay.


Eligibility Criteria:
Inclusion Criteria:

* age \> 18 years
* scheduled cardiac surgery
* expected to stay in ICU at least 1 night after surgery
* signed informed consent

Exclusion Criteria:

* Patient currently enrolled into another randomized clinical trial
* Patient currently receiving or scheduled for intermittent or continuous renal replacement therapy
* Patients with CKD of equal or more than CKD stage IV (GFR\<30 ml/min/1.73 m2)
* Patient with a kidney transplant
* Patient is not expected to survive ICU or hospital discharge
* Patient previously been enrolled and randomized into this study
* Patient has severe liver disease (Child-Pugh score \>7 points)
* Patient has a hypersensitivity (known allergy) to one or more of the included amino acids
* Patient has a congenital alteration of amino acid metabolism
* Pregnant or currently breastfeeding patients
* Patients with any of the contraindications reported in the summary product characteristics.