cyrilzakka/clinical-trials huggingface dataset:
A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis

While the repair of the epidermal barrier in atopic dermatitis is of major importance in the treatment of atopic dermatitis, most of the vehicles used may actually cause a worsening of an impaired epidermal barrier. Hydrogel vehicle is anecdotally known to be moisturizing and hydrating.This study will compare the use of Hydrogel vehicle and Eucerin Lotion in maintaining the epidermal barrier in subjects with atopic dermatitis.


Eligibility Criteria:
Inclusion Criteria:

* Definitive diagnosis of atopic dermatitis as characterized by Hanifin and Rajka criteria:
* 3 out of 4 major characteristics
* At least 3 minor characteristics
* Mild to moderate disease score of 2 or 3 by Investigator Global Assessment
* Minimum 5% Body Surface Area at Baseline
* Uniformly bilateral signs and symptoms of atopic dermatitis
* Able to understand and comply with the requirements of the study and sign Informed Consent/HIPAA forms. Subjects under the legal age of consent must also have written informed consent of the parent or legal guardian.

Exclusion Criteria:

* Allergy or sensitivity to any component of the test articles.
* Subjects who have not complied with the proper washout periods for prohibited medications.
* Significant coagulation disorder or any medical condition that, in the opinion of the investigator, contraindicates the subject's participation in the study.
* Recent alcohol or drug abuse is evident.
* History of poor cooperation, non-compliance with medical treatment or unreliability
* Participation in an investigational drug study within 30 days of the Baseline Visit.
RDEA3170 and Febuxostat Drug Interaction Study

This study will evaluate the potential pharmacokinetic (PK) and pharmacodynamic (PD) interaction between the XO inhibitor febuxostat and the investigational URAT1 inhibitor RDEA3170 and provide information for potential future clinical studies using this combination. Combination treatment using 2 drugs with different mechanisms of action may achieve improved response and may allow the use of lower doses, resulting in fewer side effects than the use of either drug alone.


Eligibility Criteria:
Inclusion Criteria:

* body weight ≥ 50 kg (110 lbs.) and a body mass index ≥ 18 and ≤ 40 kg/m2.
* no clinically relevant abnormalities in vital signs, ECG, physical examination or safety laboratory values, per the Investigator's judgment.
* a screening serum urate level ≥ 4.5 mg/dL.

Exclusion Criteria:

* history or suspicion of kidney stones.
* history of cardiac abnormalities as assessed during screening, including abnormal and clinically relevant electrocardiogram changes and/or family history of sudden death in otherwise healthy individual between the ages of 1 and 30 years.
* undergone major surgery within 3 months prior to Day 1.
* donated blood or experienced significant blood loss (\> 450 mL) within 12 weeks prior to Day 1 or gave a plasma donation within 4 weeks prior to the Screening Period.
* inadequate venous access or unsuitable veins for repeated venipuncture.
Improvement of Gait by Spinal Stimulation in Patients With Postoperative Chronic Lumbosciatalgia: Pilot Study (GaitStim)

The purpose of this study is to explore the changes in objective walking parameters induced by medullary stimulation in patients with Fail Back Surgery Syndrome, after chronic stimulation, in comparison with preoperative condition.

After the informed consent signature, a first assessment will be carried out, including: quantified analysis of walking (AQM), felt effort questionnaire, pain questionnaires, functional abilities, limitations, goals and quality of life.

The implantation of the spinal cord stimulation system will be performed in two stages: the first stage, the electrode alone will be implanted and connected to an external test stimulator, allowing a one-week stimulation test.

If the test is positive (EVA pain improvement \> or = 50%), the second step will be to connect this electrode to a Spectra WaveWriter™ internal stimulator. This stimulator delivers three different stimulation modalities: tonic, microburst and high frequency. The activated initial stimulation mode will be the tonic one.

After 3 months of "tonic" stimulation, the patient will be treated successively and in random way by 3 other different stimulation modalities during a week: microburst, high frequency, stopped stimulation (Off). The AQM and the different questionnaires will be done again, which will determine which stimulation modality is most beneficial to the patient.

Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 year old and \< or = 70 year old
* Patients with chronic neuropathic lumbo-sciatalgia (DN4 score \> or = 4/10) as part of a moderate to severe spinal surgery failure syndrome (EVA \>50/100), in who a collegial and multidisciplinary indication of medullary stimulation treatment was chosen.
* Patients awith Social Security

Exclusion Criteria:

* Vulnerable persons
* Patients who are invalid and unable to perform a quantified walk analysis
* Contraindication to surgery or anesthesia
* Patient not able to complete questionnaires
* Woman of childbearing age without effective contraception
Evaluation of Labour Progress by PC Angle

- Ultrasound during first stage of labour has a very important role in prediction of mode of delivery

-Operative delivery and cs delivery are increasing nowadays so US during labour is vital to predict these interventions

Eligibility Criteria:
Inclusion Criteria:

* primigravida
* pregnant full term
* no medical disorders

Exclusion Criteria:

* multigravida
* any medical disorders
* preterm labour
Platelet-rich Plasma in the Sacroiliac Joint

This is a double-blinded study where the injecting physicians and the patients will not know which arm they are randomized to. Each participant will be followed up for 6 months following the injection, and will have in office visits at the injection and approximately 2 weeks post injection. They will be called at month 1, 3, and 6 post injection to assess for any adverse events and number of physical therapy hours or changes in medication. At time of injection, 2 weeks post, and 1, 3 and 6 months after they will be asked to answer some questionnaires on pain and function.

Sacroiliac joint (SIJ) pain is a common and significant source of chronic low back pain. It has been broadly defined as pain located in the area of the SIJ that can be elicited by various pain provocation tests and relieved after infiltration of the joint with local anesthetic.

Essentially, a patients own blood is collected and spun at varying speeds until it separates into 3 layers, one of which is the platelet-rich plasma. Platelet-rich plasma (PRP) injections are commonly used in various conditions including chronic tendinopathy, soft tissue injuries, and ligamentous injuries. More recently, there has been a greater interest in examining the efficacy of PRP as a treatment for musculoskeletal conditions affecting joints, such as osteoarthritis (OA). To the investigators' knowledge, there are currently no reported studies evaluating the efficacy of PRP for SIJ pain. Given the previously discussed application and evidence behind the use of PRP in the knee and hip joints, the investigators propose that PRP can also provide a similar solution for treating SIJ pain.

Eligibility Criteria:
Inclusion Criteria:

* Aged 18 years and older
* Sacroiliac/Lower back pain
* Positive block
* Eligible for steroid injection
* Positive physical manual assessments

Exclusion Criteria:

* Steroid allergy
General Practitioners and Participation Rate in ColoRectal Cancer Screening

Colorectal cancer is the 2nd leading cause of cancer mortality in France. However this cancer is preventable in the majority of cases by early detection of adenomas.

In France, there is organized colorectal cancer screening, which relies on general practitioners (GPs). Tests delivered by GPs are performed in 89% of cases. However, GPs do not systematically offer the test, for time management and communication reasons. Patients expect their GPs to offer the test and to focus on their expectations. A previous study conducted on GPs showed that training in communication and motivational interviewing increases the number of tests performed by 12.2%.

In order to facilitate the promotion of screening, the investigators would like to develop a training programme for GPs focusing on the application of Motivational Interviewing (MI) techniques to the promotion of colorectal cancer screening.

Motivational Interviewing is a directive, client-centered counseling style for eliciting behavior change by helping clients to explore and resolve ambivalence.

This study is a multicenter trial in general medicine. In this randomized trial the 902 subjects will be included prospectively by the general practitioners (GP) participating in the study.

As a first step, general practitioners who have never participated in Motivational Interviewing training will be recruited and split into 2 groups by randomization, an intervention group and a control group. The interventional group will then undergo a 3 times 2-day training in Motivational Interviewing.

In a second step, the patients will be included by those GP and a self-questionnaire will be send at the inclusion and after 6, 12 and 24 months. The evaluation of the number of tests performed and the analyse of the Health Belief Model (HBM) self-questionnaire will be carried out.

At 24 months, there will be an evaluation of the denial motivation questionnaire for patients who have not participated in organized colorectal cancer screening.


Eligibility Criteria:
Inclusion Criteria:

* People with an average risk of colorectal cancer (presenting no symptoms or risk factors).
* People living in Finistère.
* People aged 50 to 74 who have never participated in organized screening for colorectal cancer.

Exclusion Criteria:

* Persons without address to receive the Health Belief Model (HBM)questionnaire
* People who do not fit the organized screening criteria
* Persons unable to give consent (patients under guardianship, curatorship, non-French speaking, illiterate)
Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty

Combination of continuous femoral block with parEcoxib vs placebo. Investigation of morphine consumption, opioid sparing effects, VAS pain scores, haemodynamics, Anxierty scores, transfusion requirements , Range of motion and rehabilitation parameters between two groups


Eligibility Criteria:
Inclusion Criteria:

* PATIENTS ASA I-II UNDERGOING TOTAL KNEE ATRTHROPLASTY

Exclusion Criteria:

Exclusion criteria for both groups included:

* Age younger than 40 years old or older than 80 years old
* ASA \> III
* Obesity (\>140 kg body weight)
* Allergy to local anesthetics
* History dependence on opioids
* Contraindications for subarachnoid anesthesia or femoral block (coagulopathy, local infection, pre-existing neurological problems, patient refusal)
* Contraindications to the administration of parecoxib
* Severe hepatic or renal disease (serum creatinine ≥ 1.7 mg/dl)
Fulvestrant in Postmenopausal Patients With Metastatic Breast Cancer

This is a retrospective chart-review study that will be based on the collection of data from electronical or paper-based medical records with available data on patients who have commenced treatment with fulvestrant after January 1st of 2007. All necessary information for the purposes of the present study will be collected with the use of a paper-Case Record Form.

To date, there are no available data on the use of fulvestrant in the treatment of postmenopausal women with metastatic breast cancer in current clinical practice in Greece. In view of this significant lack of knowledge, we designed this retrospective study in order to evaluate the effectiveness of fulvestrant in real-life settings, by obtaining data regarding the use of fulvestrant in current clinical practice among treating physicians in Greece. This retrospective study aims to address the following questions:

* What is the clinical outcome of fulvestrant treatment in terms of TTP when used in metastatic breast cancer in a real life clinical setting?
* What is the positioning of fulvestrant in the hormone therapy sequencing in metastatic breast cancer in Greece?
* What are the other clinical outcomes (ORR, duration of response, CBR) of fulvestrant treatment in metastatic breast cancer in a real life clinical setting and what is the relation between clinical outcomes and fulvestrant's position in the treatment sequence?
* What is the usual duration of fulvestrant treatment in metastatic breast cancer in the real life clinical setting and which are the reasons for treatment discontinuation?
* Treatment failure with fulvestrant: what is the next step in sequencing according to patients' breast cancer treatment history?

Eligibility Criteria:
Inclusion Criteria:

* Postmenopausal women with ER-positive and/or PgR-positive breast cancer who have failed at least one prior endocrine therapy, either as adjuvant treatment or for the treatment of advanced disease
* Patients who have received treatment with fulvestrant for metastatic breast cancer and have completed/discontinued the treatment regardless of outcome/reason for discontinuation (except for treatment discontinuation for non-clinical reasons)
* Patients who were at postmenopausal status at the time of treatment with fulvestrant

Exclusion Criteria:

* Patients who are currently undergoing treatment with fulvestrant
* Investigators/treating physicians with no available electronical or paper-based medical records
Neuroradiology Assesses Chiari Malformation's Impact on Airways, Cranial Base, and Sleep Disorders in Children.

The severity of sleep disorders in patients with Chiari malformations can vary. The investigators propose to establish a correlation between the severity of sleep-disordered breathing (SDB) and the quantitative neuroradiological data of the airways, cranial base foramina, and posterior cranial fossae

Primary objective of the study is the evaluation of sleep-disordered breathing (SDB) in two distinct pediatric populations of patients with Chiari Malformation Type 1 (CM-I) and Chiari Malformation Type 2 (CM-II).

Secondary objectives:

Stratify the presence of SDB into central and obstructive origins in the two study populations.

Assess the volume of posterior cranial fossae, airway volume, and area of cranial base foramina in both groups.

Determine the relationships between SDB and morphological-quantitative anomalies associated with CM.

Eligibility Criteria:
Inclusion Criteria:

* Children (males or females) aged between 3 years and 18 years.
* Clinical diagnosis of Chiari malformation 1 and 2.
* Presence of informed consent for the initial clinical evaluation. The investigators commit to providing appropriate informational sheets to the parents of the patients (for those included in the study) during the initial clinical evaluation.

Exclusion Criteria:

* Chiari Malformation I and II associated with neurological diseases or craniofacial malformations.
* Cranial trauma or cardiac arrest.
* Administration of centrally acting medications within 2 weeks prior to the study, except for antiepileptic treatment for patients who have had seizures.
* Associated brain and cranial base tumors.
* Refusal to sign the informed consent for the initial clinical evaluation. The investigators commit to providing appropriate informational sheets to the parents of the patients (for those included in the study) during the initial clinical evaluation.
Danish Nurses Attitudes Towards Addressing Sexual Health

Health professionals, within the field of cancer, attitude towards addressing sexual health with patients is unknown.

The aim is to investigate the attitudes of Danish cancer nurses towards addressing sexual health in their clinical work, as well as to assess differences in perceived competences and knowledge.

Method: The questionnaire Health professionals Attitudes towards Sexual Health-Danish version (PA-SH-D) is sent out to Danish cancer nurses via the Professional Society for Cancer Nurses. The questionnaire is sent out via a link via the RedCap database.

The questionnaire link is sent out to members of the Professional Association for Cancer Nurses under the Danish Nursing Council, and it is sent out via their membership register.

Health professionals, within the field of cancer, attitude towards addressing sexual health with patients is unknown.

The aim is to investigate the attitudes of Danish cancer nurses towards addressing sexual health in their clinical work, as well as to assess differences in perceived competences and knowledge.

Method: The questionnaire Health professionals Attitudes towards Sexual Health-Danish version (PA-SH-D) is sent out to Danish cancer nurses via the Professional Society for Cancer Nurses. The questionnaire is sent out via a link via the RedCap database.

The questionnaire link is sent out to members of the Professional Association for Cancer Nurses under the Danish Nursing Council, and it is sent out via their membership register.

Eligibility Criteria:
Inclusion Criteria:

* Nurses working within the area of onkology or hematology in a danish hosptial or primary sector
* nurses having daily contact with patients with a cancer diagnosis

Exclusion Criteria:

* nurses not having daily contact with patients
* nurses not working within hematology or oncology
EEG in In-hospital Patients With Seizure or Altered Mental State

In Kuopio University Department of Clinical Neurophysiology there have been designed a fast EEG electrode, that is suitable for acute emergency use. It is easy to set up, records high quality EEG and can detect the most important EEG abnormalities comparable to conventional EEG. This study will address the clinical use of acute EEG with fast electrode set in in-hospital patients who have been consulted by Medical Emergency Team because of seizure or altered mental state of uncertain etiology. Patients are going to be treated in ICU and EEG monitoring will continue for 24 hours.


Eligibility Criteria:
Inclusion Criteria:

* In-hospital patients who have a seizure or altered mental state and are going to be treated in ICU

Exclusion Criteria:

* Patiets that are not going to be treated in ICU
* Patients with a Do Not Attempt to Resuscitate - decision
The Effects of Apathy on Different Forms of Fatigue

60 participants with light neuro-cognitive disorders (30 apathetic, 30 non-apathetic) will be recruited from the CMRR (Centre Mémoire Ressources et Recherche) in Nice University Hospital and from the " Fragilily " Platform of the Nice University Hospital.

After verification by the investigator, if they meet the inclusion criteria and sign the informed consent, participants will have to wear an actigraph for one week in order to measure their level of activity.

Afterwards, participants will have to complete assessments and questionnaires to evaluate apathy (Apathy Motivation Index, Apathy Inventory), perceived fatigue (Fatigue Severity Scale, Borg scale), fatigability (6-min walking test, isometric strength test, double task), the stress level (Perceived Stress Scale) and depression (Geriatric Depression Scale).

Regarding the activity level, they will also be asked to perform tasks to evaluate their kinematic movements( through an actigraph), and their particular sensitivity towards effort and reward (through serious game 'Tap-piscine').

The total duration of the evaluation is a maximum of 2 hours.


Eligibility Criteria:
Inclusion Criteria:

* Men or women aged between 65 and 85 years old coming for consultation at the RMC and the Fragility Platform
* DSM-5 diagnosis: minor neurocognitive disorders
* Subject must read and write in French.
* Subject must be registered in the national social security scheme.
* Ability to sign free and informed consent.

For the 'apathetic' group:

- Presence of apathy/emotional symptoms: at least 2 criteria according to the diagnostic criteria for apathy and a score higher than 8.5 in the MBI affective dimension.

For the 'non-apathetic' group:

- Absence of apathy/emotional symptoms: no criteria according to the diagnostic criteria for apathy and a score of less than 8.5 in the MBI affective dimension.

Exclusion Criteria:

* Motor or sensory disabilities likely to interfere with the tests.
* Presence of major psychiatric disorders (e.g., schizophrenia, major depressive episode, bipolar disorder)
* Patient under guardianship, curatorship or under legal protection
Proximal Hamstring Avulsion Surgery Cohort Study

Proximal hamstring rupture is a rare injury, which may be immediately diagnosed.

In 1996, Sallay showed that functional results of surgical repair were better than those of conservative treatment. Surgery is now the rule. The main aim of this study is to obtain a more detailed and quantified description of the postoperative outcomes.


Eligibility Criteria:
Inclusion Criteria:

* a partial or complete hamstring proximal rupture,
* treated surgically
* diagnosis of rupture based on clinical signs and confirmed on MRI

Exclusion Criteria:

* no exclusion criteria
Foot Biomechanics and Lower Extremity Muscle Mechanics

This study is designed to investigate the relationship between foot biomechanics, balance, lower extremity muscle mechanical properties, and vertical jump in young adults. The aim is to highlight the correlations between foot biomechanics and the other parameters, as well as potential outcomes (if any).

This study is designed to investigate the relationship between foot biomechanics, balance, lower extremity muscle mechanical properties, and vertical jump in young adults. The independent variables of the study include participants' age, height, weight, calcaneotibial angle, navicular drop test, foot lengths, smoking/alcohol habits, socioeconomic status, and exercise habits. The dependent variables are the results from the Korebalance balance test, Flamingo balance test, vertical jump test, and Myoton-Pro assessment. The study aims to highlight the correlations between foot biomechanics and the other parameters, as well as potential outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Willing to participate in the study
* Aged between 18 and 25 years
* No regular exercise habits

Exclusion Criteria:

* Having a physical disability that prevents participation in the study (e.g., use of a wheelchair, walker, and/or crutches, etc.)
* Having conditions that directly affect balance, such as vertigo or multiple sclerosis (MS)
* Having a neurological disorder