cyrilzakka/clinical-trials huggingface dataset:
Airtraq Versus Standard Direct Laryngoscopy in the Pediatric Airway

Time to intubate, view to glottic opening and success rate are not different when Airtraq technique is used compared to standard direct laryngoscopy in children.

50 children (age 5 years and 11 month or younger) with expected easy intubation, scheduled for elective surgery requiring endotracheal intubation are enrolled.

Eligibility Criteria:
Inclusion Criteria:

* elective surgery requiring endotracheal intubation

Exclusion Criteria:

* predicted difficult bag-mask ventilation
* predicted difficult intubation
* rapid sequence induction
* emergency endotracheal intubation
* hemodynamic instability
* emergency surgery
* non-english speaking caregivers/parents
Safety and Efficacy Evaluation of Ultherapy™ System in Aging Hand

Enrolled subjects will receive Ultherapy™ System treatment on the back of their both hands. Follow-up visits will occur at 90 days post-treatment. Study photos will be obtained pre-treatment and at 90 days post-treatment

Before Treatment:

The subject's eligibility (inclusion/exclusion criteria) will be assessed, and the 5-point Hand Grading Scale wil be evaluated by the Investigator in charge of assessment.

Treatment:

The Investigator will apply to the eligible subject the Study Device Ultherapy™ System with 20 lines of 1.5 and 3.0 probe respectively to the back of the left and right hand .

Post-Treatment:

All subjects will visit the Institution at12 weeks from the day of procedure, and will take photos of the back of the hands. Efficacy evaluation will performed by the Photographic Evaluator.

Eligibility Criteria:
Inclusion Criteria:

* Male or female, aged 30 to 65 years.
* Score of 1 to 3 on The 5-point Hand Grading Scale
* Subjects who understand the study contents and signed the informed consent

Exclusion Criteria:

* Presence of an active systemic infectious disease
* Significant scarring in the hand to be treated
* Previous episode of surgery in the hand to be treated
* Subjects who have aesthetic addiction, drug abuse, alcohol abuse
Voiceitt for People With Impairments in Speech

The primary objective of this pilot study is to evaluate the feasibility and preliminary effectiveness of the Voiceitt app in improving communication for individuals with speech impairments due to conditions such as cerebral palsy (CP), stroke, Amyotrophic Lateral Sclerosis (ALS), or Parkinson's disease.

Conditions like CP, ALS, Stroke or Parkinson's disease, etc., cause communication impairment. There are few augmentative communication options that allow people with these impairments to communicate effectively.

Voiceitt is an app that is designed to assist people with speech impairments by using a voice recognition and dictation tool that adapts to users' unique, non-standard speech patterns. However, its effectiveness in clinical populations has not been established. This study is bridging the gap in evaluating the preliminary effectiveness and feasibility of Voiceitt app in improving communication among people with mild to moderate speech impairments.

Eligibility Criteria:
Inclusion Criteria:

* Age 13 or older
* moderately severe speech dysarthria due to conditions such as CP, stroke, ALS or Parkinson's Disease, etc.
* Ability to understand and follow instructions for using the Voiceitt app.

Exclusion Criteria:

* Severe cognitive impairments that prevent the understanding of the Voiceitt app and required training.
* Patients who have additional speech impairments other than dysarthria, such as significant aphasia or verbal apraxia.
* Severe physical impairments that prevent interaction with the app.
* Non-English speakers.
Thymoglobulin Versus Alemtuzumab Versus Daclizumab in Living Donor Renal Transplantation

The purpose of this study is to observe in a randomized prospective study the effectiveness and toxicity of Thymoglobulin vs. Campath-1H used for induction therapy in recipients of living donor (LD) kidneys, compared with the investigators standard treatment protocol of Zenapax® and maintenance immunosuppression.

To observe in a randomized prospective pilot study the effectiveness and toxicity of Thymoglobulin vs. Campath-1H used for induction therapy in recipients of living donor (LD) kidneys, compared with our standard treatment protocol of Zenapax® and maintenance immunosuppression (vide infra).

To determine the effect different antibody induction regimen on the lymphoid cell subsets of the immune system in kidney allograft recipients peripheral blood and bone marrow aspirates will be tested at surgery before transplantation and at intervals post operatively.

To treat renal transplant patients successfully in the absence of long-term calcineurin inhibition to determine if there are beneficial effects on the prevention of chronic allograft nephropathy.

Eligibility Criteria:
Inclusion Criteria:

* Age \>14 years
* Weight \>40 kg
* Primary renal allograft:living related (non HLA identical) and unrelated donor
* Negative standard cross match for T-cells
* Signed and dated consent form

Exclusion Criteria:

* Patient has previously received or is receiving an organ transplant other than kidney
* Patient has received a kidney transplant from a non-heart beating donor
* Patient has received an ABO incompatible donor kidney
* Recipient or donor is seropositive for human immunodeficiency virus (HIV)
* Patient has a current malignancy or a history of malignancy
A New Oxygen Mask for Carotid Endarterectomy Under Local Anaesthesia

The purpose of this study is to determine the effectiveness of oxygenation and patient-acceptability of a novel oxygen face mask in patients undergoing carotid endarterectomies (CEAs).

Carotid endarterectomy (CEA) is a procedure to remove plaques from a carotid artery (one of the two main arteries supplying blood to the brain). The procedure is effective at reducing the risk of subsequent stroke. To access the artery, an incision is made in the artery wall which means that the artery must be clamped in order to prevent blood loss. Consequently, the blood supply (and therefore oxygen supply) to the brain is reduced. To ensure that the patient has sufficient oxygen to avoid brain damage, this procedure is often carried out under local anaesthetic as this means the anaesthetist can talk to them during the operation; by this means they can determine the patient's conscious level and whether or not they need supplementary oxygen.

There are various ways to administer the supplementary oxygen. Most oxygen masks completely cover the mouth and nose which inevitably limits patient-doctor communication. Oxygen is therefore usually administered via nasal tubes. However, the actual level of oxygen taken in by the patient is very hard to measure, and at best is only 40%.

A novel mask with an open design. By creating a 'vortex' of oxygen it can deliver higher concentrations of oxygen to the patient without significantly interfering with doctor-patient communication and, at the same time, improving patient comfort.

We wish to test the efficacy of this mask during CEA and plan to do this by measuring the oxygen content of blood directly using blood samples; we also monitor markers of brain damage which may occur from lack of oxygen. Finally, we will survey the patients as to acceptability of the mask.

Eligibility Criteria:
Inclusion Criteria:

* Male or female
* Booked for carotid endarterectomy under local anaesthetic
* Competent to consent to inclusion

Exclusion Criteria:

* Patient refusal and inability to provide consent
* Patients who are unable to understand instruction or communicate effectively
* Aged below 16 years
* Decreased conscious level during the period of study
Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery

The main aim of the present study was to investigate the effect of preemptive dexamethasone and methylprednisolone to prevent pain, swelling and limitation in mouth opening following third molar extraction.

Third molar surgery is often associated with significant post-surgical sequelae. The trauma caused to soft and bony tissue can result in considerable pain, swelling and trismus. Symptoms begin gradually having a peak 2 days after extraction. The use of corticosteroids such as dexamethasone and methylprednisolone can be a valuable tool when performing moderate to moderately severe oral surgical procedures. No clear consensus have emerged yet regarding patient selection, dosage, timing and type of administration of steroid. In this light, this clinical trial aim to compare the effect of preemptive dexamethasone and methylprednisolone to prevent pain, swelling and limitation in mouth opening following third molar extraction.

Eligibility Criteria:
Inclusion Criteria:

* Patients with indication of asymptomatic bilateral extractions of lower third molars
* Aged 18 years or older;
* Have a good health and no disease;

Exclusion Criteria:

* Patients with history of any medication treatment within 15 days before the beginning of the research, history of allergy to the drugs, substances or materials used in this study, pregnancy or lactation
Mothers and Girls Dancing Together Trial

The purpose of this study is to examine the feasibility and efficacy of a 12-week afterschool afro-centric dance physical activity program for daughters and mothers on the physical activity level of African-American girls.

Like African-American women, African-American girls suffer disproportionately from obesity and Type 2 diabetes mellitus. One factor strongly associated with the development of obesity and Type 2 diabetes mellitus disparities in children is low physical activity levels. Low physical activity is more prevalent in African-American girls, pointing to the critical need for effective physical activity interventions. For a physical activity intervention message to be effective among African-American girls, the program must be enjoyable and tailored to African-American girls and women. One possibility for an appropriate physical activity intervention is afro-centric dance, which has strong cultural and historical significance in the African-American community. This form of physical activity may provide girls with sustained bouts of moderate-to-vigorous physical activity. There appears to be a strong positive correlation between parental and children physical activity levels. In the African-American culture, maternal health behaviors in particular have a strong influence on children's health behaviors. Currently, there are no studies that examine the effects of a daughter-mother Afro-centric dance program on the physical activity levels of African-American girls. Therefore, the purpose of this study will be to examine the feasibility and efficacy of a 12-week physical activity intervention consisting of afro-centric dance and its ability to affect the physical activity levels of African-American girls. If investigators identify afro-centric dance as a sustainable form of physical activity for African-American daughters and mothers, investigators can use this intervention to significantly reduce obesity and Type 2 diabetes mellitus in these groups.

Eligibility Criteria:
Inclusion Criteria for Girls:

* 7 -10 yrs old on the date of randomization
* Defined as African-American if her parent/guardian identifies her as such
* No inclusion criteria will be used for mothers

Exclusion Criteria:

* Unable to wear the activity monitor
* Unable to participate in physical activity, require oxygen supplementation for exertion, have a developmental or physical disability preventing participation, cannot increase their physical activity for any reason, uncorrected structural heart disease)
* If girl and/or mother is unable to read, understand, or complete the informed consent or surveys in English.
* Musculoskeletal injuries or disorders that would prevent participation
* Taking diabetes (type 1 or 2), renal diseases, eating disorder, pregnancy medication
* Take medications affecting growth (e.g., insulin, oral hypoglycemic, thyroid hormone)
Role of UC-MSC and CM to Inhibit Vision Loss in Retinitis Pigmentosa Phase I/II

The study will perform UC-MSCs and CM transplantation. There are two groups with different dosages. The first group will be transplanted with 1.5 million cells, meanwhile, the second group is 5 million cells. Each group consists of 30 subjects. All groups will be transplanted via the peribulbar route. All groups will be observed until six months.

The eyes we will give the transplant should be given an aseptic and antiseptic technique to prevent contamination from the inside and outside. Sterile cover attached to other parts of the face except for the eyes. 1.8 ml Umbilical Cord-derived Mesenchymal Stem Cell (UC-MSC) preparations are suspended in Conditioned Medium (CM) until it reaches a 2 ml volume of cell suspension. Two dosages will be prepared, 1.5 million and 5 million of UC-MSC. Stem cell suspension will be injected by peribulbar, and patients will be given a quinolone antibiotic if the injection is done. On day 1st and day 7th after therapy, patients will be observed the presence of infection, inflammation, and increased eye pressure. On day 7th, day 30th, and day 90th after therapy, patients will do a visual field test, visual acuity test, electroretinography, funduscopy, and Optical Coherence Tomography examination. The observations will be written in the table and analyzed by a statistic.

Eligibility Criteria:
Inclusion Criteria:

* Visus more than 20/100
* Have more than 0.68 uV on conical receptor cell amplitude checked by ERG
* Visual field equivalent diameter more than 10o
* Willing to sign informed consent as research subjects
* Willing to do the peribulbar injection with mesenchymal stem cells isolated from umbilical cord tissue
* Willing to do visual field checks with Humphrey's perimetry, vision tests with Snellen boards, Optical Coherent Tomography (OCT) examinations, electroretinogram examinations, and fill out a quality of life questionnaire

Exclusion Criteria:

* Pregnant or nursing women
* Positive result of HIV test
* Have a history of eye tumors
* Under immunosuppressive treatment or other drugs that can affect the growth of transplanted stem cells
* Have another eye disease such as diabetic retinopathy, uveitis, cataract, and glaucoma
* Do not come to control according to the schedule determined by the researcher (loss to follow up)
Study of VX-770 on Desipramine

The objective of this study is to evaluate the effects of VX-770 on Desipramine


Eligibility Criteria:
Inclusion Criteria:

* Subjects must be male or female and between 18 and 55 years of age
* Subject must have a body mass index (BMI) from 18 to 30 kg/m2
* Subject must be judged to be in good health

Exclusion Criteria:

* History of any illness that, in the opinion of the investigator or the subject's general practitioner, might confound the results of the study or pose an additional risk in administering study drug(s) to the subject
* Subjects who have human immunodeficiency virus, hepatitis C, or active hepatitis B
* Female subjects and male subjects with female partner(s) who are pregnant, nursing, or planning to become pregnant during the study or within 90 days of the last dose of study drug
A Study to Investigate the Effects of Tibolone (Livial®) on Breast Tissue in Postmenopausal Women With Breast Cancer (Study 32971)(P06469)

The primary purpose of this study is to compare changes in the expression of the proliferation marker Ki-67 in malignant breast tissue after treatment with tibolone or placebo in postmenopausal women who need to undergo surgery for primary breast cancer


Eligibility Criteria:
Inclusion Criteria:

* postmenopausal women of any age
* requiring surgery for early invasive primary breast cancer (clinically stage I or II; T1-T3; N0-1; M0), with estrogen receptor-positive tumor(s)
* body mass index between 18 and 2 kg/m2, inclusive
* must be willing to give voluntary written informed consent.

Exclusion Criteria:

* healthy subjects
Comparison of Different Methods for Reducing Pain From Influenza Vaccine Injections

The purpose of this study is to compare four different analgesic strategies in adults undergoing routine influenza immunization

In this study, we will compare relative effectiveness of 4 analgesic strategies (i.e., topical local anesthetics, vapocoolant spray, tactile stimulation and distraction) in adults undergoing routine immunization in order to provide further evidence of the effectiveness of each intervention and to determine if one method is superior to another. We are not including a 'no treatment' group because we do not wish to subject participants to unnecessary pain when there are available analgesic treatments. Moreover, in the presence of a 'no treatment' group, we cannot rule out a placebo effect for all treatment groups unless we provide a matched placebo for each intervention, which is not feasible. In future studies, we plan to address the added benefit of combining analgesic interventions (i.e., evaluating the effect of a multimodal approach).

Eligibility Criteria:
Inclusion Criteria:

* Healthy adults aged \>18 years of age undergoing voluntary immunization with influenza virus vaccine

Exclusion Criteria:

* Pre-medication with any of the analgesic interventions in this study,
* Chronic pain syndromes/conditions
* Receiving systemic analgesics and sedatives
* Abnormal circulation (e.g., Raynaud's phenomenon)
* Allergy/hypersensitivity to amide local anesthetics
* Allergy to influenza virus vaccine or constituents
* Prior participation in the trial
* Inability to understand the VAS
* If suspected to be pregnant, pregnant or breastfeeding (due to possible treatment with liposomal lidocaine).
Topical Sulfasalazine and Oral Lichen Planus

Oral lichen planus (OLP) is a chronic inﬂammatory disease that affects the mucosal membrane. T-cell mediated damage against the mucosal epithelial cells is implicated in the pathogenesis of OLP, although the exact mechanism is unknown.

Sulfasalazine is extensively used in inﬂammatory bowel disease and is effective on immune-related inﬂammatory disease such as Crohn's disease, rheumatoid arthritis, and Behcet's disease. In spite of its effectiveness, the anti-inﬂammatory mechanism is not clearly understood.

* Patients will be recruited in a consecutive manner from the outpatient Diagnostic center, Faculty of Dentistry, Cairo University.
* A total number of 46 patients will be included in this study. The 23 patients categorized as study group (S group) will use topical sulfasalazine prepared by dissolving one tablet of commercially available (COLOSALAZINE - EC 500 MG 20 TAB, manufactured by: Alexandria Company for Pharmaceuticals \& Chemical Industries, Alexandria) in 100 ml of distilled water 4 times per day as a mouth wash combined with topical corticosteroids 4 times per day as a topical gel in an alternate sequence. There are no expected side effects of this treatment due to its topical application however, the patient will be instructed to stop the treatment if any adverse reactions occur such as allergy and coming to the clinic next day.
* The 23 patients categorized as control group (C group) will receive topical corticosteroids gel only 4 times per day. The treatment regimen will be continued for 4 weeks with follow up visits one per week.
* Medical history will be taken, thorough oral examination will be done, and a full questionnaire will be filled for each patient.
* All participants in the study groups will undergo adequate oral hygiene performance measures with complete removal of plaque and calculus as they implement intraoral inflammation and intensify both extension and symptoms of OLP lesions. Patients will be advised to evade accidental trauma on soft tissues using soft bristles toothbrush. Acidic, spicy, hard, hot food and beverages will be avoided.

Eligibility Criteria:
Inclusion Criteria:

* - Patients with 30-65 years old
* Patents with atrophic OLP

Exclusion Criteria:

* - Smokers
* pregnant or lactating ladies and
* Patients under topical or systemic steroids during the last two months
* Patients using lichenoid reaction-inducing drugs,
* Patients with positive hepatitis C virus (HCV) antibodies, diabetes and hypertension
* Patients having amalgam filling adjacent lesions will not also be included
An Eight-Week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Major Depressive Disorder

The objective is to evaluate the efficacy and safety of two doses of SSR149415 (250 mg and 100 mg twice daily) compared to placebo and escitalopram 10 mg once daily in outpatients with major depressive disorder.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of major depressive disorder, as defined by DSM-IV criteria and confirmed by the semi-structured MINI, recurrent episode.

Exclusion Criteria:

* Total score of less than 24 on the MADRS.
* HAM-D total score less than 18.
* Duration of the current depressive episode less than 1 month or greater than 2 years.
* Patients with a history or presence of bipolar disorders or psychotic disorders.
* Patients with alcohol dependence or abuse or substance dependence or abuse in the past 12 months except nicotine or caffeine dependence.
* Patients who have used the following prior to entry into Acute Phase: antipsychotics within 3 months, fluoxetine within 1 month, MAOIs within 2 weeks, other antidepressants, anxiolytics, or mood-stabilizer (lithium, anticonvulsants) within 1 week except as allowed in the protocol.

The investigator will evaluate whether there are other reasons why a patient may not participate