cyrilzakka/clinical-trials huggingface dataset:
Cortical Bone Plate Versus Cortico-cancellous Block Graft

Horizontal ridge augmentation using either cortical bone plate technique or cortico-cancellous block graft was the aim of the study. Bone quality was analyzed histomorphomterically, and horizontal dimensional changes were assessed using CBCT.


Eligibility Criteria:
Inclusion Criteria:

* Eligible patients aged 18 years or older with partial edentulism of the mandible
* The residual ridge width must be 4 mm or less
* Intra-oral donor sites should be available in the external oblique ridge and symphyseal area

Exclusion Criteria:

* Patients with general contraindications for implant surgery such as uncontrolled diabetes
* Irradiation of the head and neck region
* Intravenous bisphosphonate
* Pregnancy
* Smokers, alcoholics and drug abusers
MR Imaging of the 3D Inguinal Hernia Scaffold ProFlor

Demonstrating through MRI sequuences the regenerative features of the 3D inguinal hernia scaffold ProFlor

The biological response of the 3D inguinal hernia scaffold ProFlor has been evaluated through MRI signal intensity (SI) at three defined post-implantation stages: short, mid and long term. The SI of ProFlor has been compared to the SI of the neighbouring muscles and fat. As additional proof, histology of tissue specimens excised at the identical post-implantation stages from porcine models in the fame of a previous experimental attempt were also evaluated. The results of this experimental trial have ben already published in 2011 - ref: A new prosthetic implant for inguinal hernia repair: its features in a porcine experimental model. Artificial Organs 2011;35(8):E181-E190

Eligibility Criteria:
Inclusion Criteria:

* patients who underwent inguinal hernia repair with the 3D inguinal hernia scaffold ProFlor

Exclusion Criteria:

* all individuals who underwent inguinal hernia repair withouth the 3D inguinal hernia scaffold ProFlor
Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia

This clinical trial studies how well simplified patient care strategy works in decreasing early death in patients with acute promyelocytic leukemia. Implementing simplified acute promyelocytic leukemia guidelines along with support from acute promyelocytic leukemia experts may decrease deaths and improve survival.

PRIMARY OBJECTIVES:

I. To evaluate if the proposed patient care strategy, that includes use of simplified guidelines along with acute promyelocytic leukemia (APL) expert support, decreases the one-month induction mortality rate from 30% to under 15%.

SECONDARY OBJECTIVES:

I. To assess the overall survival 1 year after accrual is completed. II. To assess incidence and severity of differentiation syndrome. III. To correlate outcomes with time to initiation of all-trans retinoic acid (ATRA) from diagnosis or suspicion of diagnosis.

IV. To compare outcomes between academic and community centers separately. V. To evaluate factors associated with outcome.

OUTLINE:

Patients receive standard of care treatment for APL. Patients and doctors regularly discuss with an APL expert to identify and mange treatment.

After diagnosis, patients are followed up for 1 year.

Eligibility Criteria:
Inclusion Criteria:

* Confirmed to have a diagnosis of APL, which is defined as:

  * Positive t(15:17) by fluorescence in situ hybridization (FISH) or conventional karyotype
  * Positive promyelocytic leukemia/retinoic acid receptor PML/RAR alpha by polymerase chain reaction (PCR)
* Patients must accept treatment and supportive care guidelines
* Referrals must be made as early as possible but no later than 5 calendar days after ATRA therapy is initiated; consent can be obtained up till day 7 or earlier
* Co-management can be started as soon as referral is made including weekends; the physician at the outlying facility should make every effort to call the APL expert at the first suspicion of APL
Study on the Stoma Appliance Flexima®/Softima® 3S

To evaluate the satisfaction of patients of the Flexima®/Softima® 3S with 6 months follow-up.

The primary variable is to evaluate the degree of satisfaction of patients in terms of leakage prevention, comfort and patient's feeling of security to the Flexima®/Softima® 3S.

The primary variable is to evaluate the degree of satisfaction of patients in terms of leakage prevention, comfort and patient's feeling of security to the Flexima®/Softima® 3S.

Eligibility Criteria:
Inclusion Criteria:

* Patient is at least 18 years old
* Patient who has had a colostomy or an ileostomy or a jejunostomy or an urostomy for at least 1 month
* Patient agreeing to participate to the study and having signed the informed consent form/information letter in accordance with local requirements
* Patient for whom the use of Flexima®/Softima® 3S has already been decided within the regular planning of his treatment

Exclusion Criteria:

* Patient with cognitive problems, according to the investigator, preventing him from answering a questionnaire or for whom the evaluation could be a problem
* Patient taking part in another clinical evaluation
* Patient having more than one stomy
* Patient vulnerable and under legal protection
* Patient having had an known allergy to one of the components of the appliance
* Patient previously using Flexima®/Softima® 3S
Impact of Patient Blood Management (PBM) at the Schulthess Clinic

Aim of this study is to analyze the transfusion requirements of allogenic blood products at the Schulthess Clinic for patients that had major orthopedic or major spine surgery between 2019 and 2024 order to identify patients at risk for transfusion. Moreover, impact of transfusion requirements and other measures of PBM on patient outcomes will be assessed. These data are required to further improve PBM at the Schulthess Clinic.

At the Schulthess Clinic a significant reduction of RBC's, fresh frozen plasma (FFP) and platelets transfusion could be observed between 2018 and 2022 during the stepwise introduction of PBM for all patients undergoing major orthopedic and spine surgery. RBC, FFP and PT transfusion declined by 76.3%, 73.5% and 99.2% over the 5-year period. Unfortunately however, at the moment no detailed analysis with respect to risk factors for transfusion, specific interventions or outcomes is available. The hypothesis is that the already known reduction of allogenic blood product transfusion at the Schulthess Clinic can be attributed to patients undergoing major primary joint arthroplasties, revision operations and major spine surgery. We assume that patient and procedure related risk factors over time did not significantly change while we expect a major impact of changed transfusion requirements and the stepwise PBM implementation on patient outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing primary joint arthroplasties or revision surgery: CHOP Code: 81.51, 81.52, 81.52, 81.54
* Patients undergoing major spine surgery: CHOP Code: 7A.6, 7A.7

Exclusion Criteria:

* Patients who did not sign general informed consent
Flexibility Deficit in Chronic Ankle Instability

chronic ankle instability could be associated with some proximal deficits as in hip and knee regions. these deficits include alternations in motor neurons pools excitability, muscle strength, kinematics and kinetics. this study add muscle inflexibility to the preciouse literature.

Background: influence of a localized injury in a distal joint on the function of proximal muscles is an important consideration in assessment and treatment of musculoskeletal injuries. Up to the investigator's knowledge, there is no study assess flexibility changes in CAI. Objectives: The objective of this study is to investigate Hamstring flexibility in CAI. Material and methods: The study conducted on 42 subjects with unilateral CAI and controls had measure of hamstring flexibility using digital inclinometer during passive knee extension test .Results: Revealed statistical and clinical significant difference between non-injured control group and CAI group with decreased hamstring flexibility in the later. Conclusion: CAI subjects have proximal muscular affection include hamstring tightness which may alter sacroiliac joint stability and subsequently back pain.

Eligibility Criteria:
Inclusion Criteria:

* The control group was self-reported to be healthy
* Had no ankle injury history
* Matched with CAI patients in gender, dominance side and simulated injured side
* CAI group had a self-report of a past history of unilateral ankle inversion injury since at least more than 1 year before the study onset which required a period of protected weight bearing and/or immobilization at least one day
* Patient reported a tendency for the ankle to give way and/or recurrent ankle sprain
* Perceives that the ankle was chronically weaker, more painful and/or less functional than the other ankle or than before first

Exclusion Criteria:

* Had a history of lower extremity injury
* Surgery or fracture
* History of low back dysfunction that required medical or surgical intervention within the last year, Current participation in formal or informal rehabilitation
* History of hamstring strain
* Bilateral ankle sprain injury
* Ankle injury within 3 months of participation
* History of ankle fracture and any neuromuscluskeletal disease could affect the condition.
Safety, PK and Effectiveness of IV Peramivir Versus Oseltamivir in Pediatric Subjects With Uncomplicated Influenza

This study will evaluate the safety, pharmacokinetics and effectiveness of a single dose of IV peramivir compared to a standard 5 day course of oral oseltamivir in the treatment of pediatric subjects with acute uncomplicated influenza.


Eligibility Criteria:
Key Inclusion Criteria:

1. Clinical signs and symptoms consistent with acute influenza infection consisting of an oral temperature ≥ 100°F (37.8°C) or rectal temperature ≥ 101.3ºF (≥ 38.5ºC) with at least one respiratory symptom (cough or rhinitis) OR Positive influenza determined by PCR or Rapid Antigen Test
2. Onset of symptoms no more than 72 hours before presentation for screening for subjects \< 2 years old.

Key Exclusion Criteria:

1. Pregnant or breast-feeding females
2. Development of symptoms while hospitalized
3. Presence of a chronic disease or illness that may indicate increased risk for influenza-related complications
4. Presence of immunocompromised status
Effects of Plyometric Training and Eccentric Muscle Training on Functional Performance in Weightlifters

Stretching, pressing, and lifting large weights with speed and balance all require strong muscles. In plyometric exercise, the same muscle must be stretched and rapidly contracted in order to make quick, strong motions. Plyometric exercises include explosive jumps, hops, bounds, and skips. A major component in becoming a better weight lifter is plyometric training that focuses on the lower limb. Additionally, as the muscle produces and stores kinetic energy, it is crucial to increase muscle power, strength, and endurance. Eccentric muscular activity relate to the dynamic extension of muscle tissue in resistance to an external force or load. Eccentric muscular activities have been demonstrated to induce a higher elevation of molecular signalling pathways connected to muscle and connective tissue anabolism and increased activation of satellite cells.

This study will be a Randomized control trial and occur on improving functional performance in weightlifters. The inclusion criteria are, training will perform only elite weightlifters, aged between 20-30 years, and have 4-5 years of weightlifting experience. In this study we will compare two groups including 20 participants, 10 participants will be trained in plyometric exercises and 10 participants will be on eccentric muscle training and we will analyze which group will enhance functional performance. We will use an Assessment scale to assess the upper and lower extremity dysfunction through the Upper extremity assessment scale and Lower extremity assessment scale.

To compare the effect of plyometrics training and eccentric muscle training to improve functional performance in weightlifters.

The study will be Randomized control trial. Non-Probablity propulsive techninque DATA COLLECTION TOOLS Lower Extremity Functional Scale Upper extremity Functional scale Vertical jump \& long jump Seated medicine Ball toss V-sit and reach test The Data will be analyzed using SPSS for windows software version 25. Statistical significance P=0.05. After assessing the normality of current data by shapiro wilk test. it will be decided whether parametric or non parametric test will be used within the groups or between 2 groups.

Eligibility Criteria:
Inclusion Criteria:

* Male
* Elite competitive weightlifters
* Age 20-30 year
* Weightlifting experience 4-5 years
* The weightlifter can perform all functional activities

Exclusion Criteria:

* female
* Low BMI
* History of injury,
* History of surgery and pain
Collagen-PVP vs Hylan G-F 20 in the Treatment of Knee Osteoarthritis

Articular cartilage degradation is the main characteristic of osteoarthritis (OA), involving enzymatic and inflammatory mechanisms that change it into a chronic disease. Since articular cartilage shows limited regenerative ability, several intra-articular drugs have been developed in order to decrease inflammation and provide a better clinical outcome to the patient.

This study aims to compare effectiveness of the treatment with intra-articular administration of collagen-PVP versus hylan GF 20, using the International Knee Documentation Committee (IKDC) score, 6 months after treatment. Hypothesis to test is: If effectiveness of intra-articular collagen-PVP is not lower than hylan GF 20 treatment in knee osteoarthritis subjects, then, statistically significant difference would not exist in IKDC score mean increase among treatment groups, after six months.

Eligibility Criteria:
Inclusion Criteria:

* Aged between 40 and 80 years old
* Osteoarthritis in the knee rated II or III (Kellgren-Lawrence Grading Scale).
* Pain intensity (MOS Pain Severity Scale) greater than 40.
* Subject able to understand, co-operative and reliable.
* Written informed consent.

Exclusion Criteria:

* Acute arthritis in the knee.
* Ongoing anticoagulant therapy.
* Skin infection at the injection site.
* Systemic or intraarticular (target knee) corticosteroids in the past 3 months.
* Viscosupplementation (target knee) in the past year
* Arthroscopy/osteotomy/surgery in the past 5 months (target knee).
* Any surgery scheduled in the next 6 months
* Concomitant rheumatic disease (rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, fibromyalgia).
* Severe varus/valgus deformity (\>15°).
* Frontal deformity greater than 20 degrees
* History of allergy or hypersensitivity to hyaluronic acid or avian proteins
* History/present evidence of: metabolic joint diseases; crystal arthropaties; ochronosis; acromegaly; haemochromatosis; Wilson's disease; primary osteochondromatosis; heritable disorders.
Retrospective Observational Study of Italian Cohort of Lymphoma Patients (RETRO-LYMPH)

observational, non-interventional, retrospective, single-center study focusing on patients with lymphoma / lymphoproliferative syndrome between January 1980 and September 2021

observational, non-interventional, retrospective, single-center study focusing on patients with lymphoma / lymphoproliferative syndrome between January 1980 and September 2021.

Study objectives are to enrich the data on the prognostic role of clinical and epidemiological factors associated with clinical and epidemiological data of patients;

* to identify the factors that affect the evolution of the disease, such as lifestyle and occupational factors, as well as the type of treatment;
* to provide a platform for future research projects;
* Description of the various therapies that have occurred over time, duration of treatment, causes of interruption of treatment, responses;
* Description of the adverse events / safety of the various therapies for lymphoma and lymphoproliferative syndromes;
* Patient survival. Descriptive analyses will be conducted by tabulating frequency distributions and percentages and mean and median values, standard deviations, quartiles and extreme values for continuous variables. Progression-free survival, disease-free survival and overall survival will be examined using Kaplan-Meier point estimates

Eligibility Criteria:
Inclusion Criteria:

* Age greater than or equal to 18 years of enrollment
* Diagnosis of lymphoma or lymphoproliferative syndrome between January 1980 and September 2021
* Signature of the informed consent form where applicable

Exclusion Criteria:

* none
Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs

To evaluate the corrected QT interval change(automatic-reading) after single oral administration of escitalopram, quetiapine and moxifloxacin versus placebo in healthy Korean Adults.

Randomized, Open-label, Placebo-controlled, 4-way crossover study

Eligibility Criteria:
Inclusion Criteria:

1. Healthy subjects aged 20 - 40 years.
2. A body weight in the range of 50 kg (inclusive) - 90 kg (inclusive) and a body mass index (BMI) in the range 19.0 kg/m2 (inclusive) - 25.0 kg/m2 (inclusive).
3. Sufficient ability to understand the nature of the study and any hazards of participating in it. Provide written informed consent after being fully. informed about the study procedures.

Exclusion Criteria:

1. Presence or history of hypersensitivity or allergic reactions to drugs including investigational product (Escitalopram, Quetiapine, Moxifloxacin)) or other quinolone group antibiotics.
2. Subject judged not eligible for study participation by investigator.
Micronutrient and Additive Modifications May Optimize Diet To Health

This is a prospective clinical intervention trial where patients with moderately active ulcerative colitis are randomized to either normal healthy diet or a diet with elimination of emulsifying agents within the E 400-group with special respect to carragenan, CMC and polysorbates. At study start and end after one month their diet, clinical characteristics and microbiota will be analysed. The hypotheses are that their disease activity measured with calprotectin and their microbiota will improve after intervention.

Patients with ulcerative colitis attending the out-patient clinic at Skåne university hospital with calprotectin 100-600 will be invited to participate in this diet intervention study. They will be divided into two arms with 35 patients in each, normal diet or E-400 elimination. The diet will be recorded at study start and end with a food diary for four days and a food frequency questionnaire regarding E-400 intake. The patients clinical characteristics (demographics) and disease activity (diarrhoea frequency, blood in stools, abdominal pain, CRP and calprotectin) will be recorded and microbiota collectted. The hypotheses are that the activity measured with clinical characteristics and calprotectin as well as their microboita measured with dysbiosis index and total genom with NGS will improve significantly.

Eligibility Criteria:
Inclusion Criteria:

* Ulcerative colitis,
* Moderately active
* Stable medication

Exclusion Criteria:

* Severe disease
* Recent surgery
* Proctitis
* Pregancy
* Treatment with antibiotics
* Difficulties in understanding the information about the study
* Multimorbidity that makes it impossible to participate
Depression Online Assessment and Therapy

One Aim of the current study is to better understand why some patients suffering from depression do not seek professional help by doctors but in the internet.

Furthermore patients with depression will receive Online Therapy for depression. Aim of this part of the study is to investigate whether quality of life changes accordingly to improvement of symptoms after online therapy.

* German speaking patients can register online. There will be no side visits.
* After screening: patients which meet inclusion criteria and no exclusion criteria can take part in online therapy for depression.
* After 12 weeks 2nd online survey. After this survey patients can use the program the following 6 months (follow-up)
* After 6 months 3rd and last online-survey.
* According to the aims of the study cross-sectional as well as longitudinal data will be obtained and analysed

Eligibility Criteria:
Inclusion Criteria:

* German language
* depression at least slight according BDI (Beck depression inventory) and at least 2 weeks

Exclusion Criteria:

* severe depression according BDI
* suicidal ideation
* alcohol or drug dependency
* history of psychotic symptoms
* history of bipolar disorder or previous mania
* current in-patient care or semi-residential treatment
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.


Eligibility Criteria:
Inclusion Criteria:

* Generally healthy men and women aged 18-70
* BMI between 30-40
* Less than 1 hour of exercise per week
* Women:

  1. may be pre or post menopausal

Exclusion Criteria:

* Type 1 or Type 2 diabetes
* Thyroid disease
* History of lung disease
* Active use of nicotine
* Severe plasma lipid disorders
* Taking hormone replacement drugs, blood thinners, or thiazoladinediones
* Women:

  1. Currently going through menopause or peri-menopause
  2. Pregnant or breastfeeding
  3. History of Polycystic Ovary Syndrome
Behavioral Indicators of Pain:Tool Development With Concurrent and Construct Validity

The purpose of the pilot study is to validate an assesment tool to be used in the assessment of pain in the verbal, congitively intact patient. The ultimate goal is to be able to validate this tool in the non-verbal/cognitively impaired patient.

Patinets will be observed for 2 six hour periods. Patients will be videotaped; every 10 minutes: EMG reading will be obtained; hourly - vital signs, pain score and saliva cortisol from "spit" will be obtained.

Eligibility Criteria:
Inclusion Criteria:

* In-patients with Pain diagnosis

Exclusion Criteria:

* Unable to talk and or understand basic instructions
* Under age 18 or over age 75
* Receiving pain medications regularly