cyrilzakka/clinical-trials huggingface dataset:
Modification of Blood Pressure Levels and Oxygen Saturation in Patients Undergoing Conscious Sedation

The objective is to compare the changes produced in cardiological and respiratory parameters in three groups of patients undergoing oral surgery. The first group was treated with local anesthesia, a second group with local anesthesia plus oral conscious sedation with midazolam, and a third subject under anesthesia local with inhalation sedation with nitrous oxide.

A total of 90 non-cooperative phobic adult patients belonging to the group of patients of the University Master in Oral Surgery, Implantology and Periodontics of the University of León will be included in this study, after their information and acceptance of verbal and written consent, separated into three groups without significant differences in age, sex, smoking habits, cardiac or respiratory pathologies, and will be treated by advanced procedures of Oral Surgery, Periodontics and Implantology such as Sinus lift, Periodontal Surgeries and Implant Surgeries.

They will be randomly divided into three groups of 30 patients each. They will be given a prior consent both of the procedures to be performed and of the sedation procedure to which they will be subjected, if that is the case, without knowing what dose they will be administered. In case of being sedated, they will be informed verbally of the details concerning the procedure.

A total of 90 non-cooperative phobic adult patients will be included in this study, after their information and acceptance of verbal and written consent, separated into three groups without significant differences in age, sex, smoking habits, cardiac or respiratory pathologies, and will be treated by advanced procedures of Oral Surgery, Periodontics and Implantology such as Sinus lift, Periodontal Surgeries and Implant Surgeries.

Initially, a complete health questionnaire will be filled out in all patients, and Partial Oxygen Saturation (SpO2), Respiratory Rate, Respiratory Volume in the form of Forced Vital Capacity (FVC), and also Forced Expiration Volume will be recorded as respiratory records (FEV) and Maximum Expiratory Flow (PEF), and as cardiac registers the Heart Rate, and the Systolic and Diastolic Blood Pressure before starting the procedure, records that will be repeated every 5 minutes during and until the end of it. The parameters will be recorded every 5 minutes, except for the parameters VFC, FEV1 and PEF that will be recorded exclusively at the beginning and at the end of the procedure.

Eligibility Criteria:
Inclusion Criteria:

* Clinical Diagnosis of phobic patients
* Not having contraindications to be anesthetized or sedated, and
* Present an acceptable state of health (ASA I and ASA II).

Exclusion Criteria:

* Clinical conditions; ASA III, ASA IV and ASA V
Surgical Skill Labs for Robotic Mastectomy and Educational Program Using a Surgical Guide by Artificial Intelligence

The goal of this prospective study is to investigate the satisfaction, NASA-Task Load Index (TLX), and surgical proficiency of a robotic breast surgery education program using cadaver or porcine models, as well as to develop an AI-based surgical guide for utilization within the educational program in trainees for robotic breast surgery.

The main question\[s\]it aims to evaluate :

* Satisfaction questionnaire of a educational program
* NASA-TLX of a educational program
* global evaluative assessment of robotic skills (GEARS) of a robotic breast surgery for surgical proficiency

Participants will participate the educational program and fill out a satisfaction questionnaire and NASA-TLX.

The tutor evaluates GEARS for 15 minutes at the beginning and end of training.

After the development of the surgical guide based on AI, researchers will compare a training group with or without surgical guide to see the effect of the surgical guide.

The goal of this prospective study is to investigate the satisfaction, NASA-Task Load Index (TLX), and surgical proficiency of a robotic breast surgery education program using cadaver or porcine models, as well as to develop an AI-based surgical guide for utilization within the educational program in trainees for robotic breast surgery.

The main aims to evaluate the satisfaction questionnaire, NASA-TLX of a educational program, and global evaluative assessment of robotic skills (GEARS) of a robotic breast surgery for surgical proficiency.

Participants will participate the educational program and fill out a satisfaction questionnaire and NASA-TLX. The tutor evaluates GEARS for 15 minutes at the beginning and end of training. After the development of the surgical guide based on AI, researchers will compare a training group with or without surgical guide to see the effect of the surgical guide.

The inclusion criteria is as below; a breast surgeon who completed the basic dry lab for surgical robot platform before the educational program and a trainee who signed a informed consent.

The exclusion criteria is as below; a trainee who did not sign a informed consent and a trainees judged by the researcher to be inappropriate for participation in this study.

The estimated participants is at least 64.

This study will present the descriptive statistics on the collected data of the satisfaction questionnaire, NASA-TLX, and GEARS results. Categorial variables will be examined by the chi-square test or Fisher's exact test. Continuous variables will be examined by t-test or M-W test if needed. Additionally, binary regression test will be tested for multivariate analysis.

Eligibility Criteria:
Inclusion Criteria:

* A breast surgeon who completed the basic dry lab for surgical robot platform before the educational program
* A trainee who signed a informed consent

Exclusion Criteria:

* A trainee who did not sign a informed consent
* A trainees judged by the researcher to be inappropriate for participation in this study
HCV-796 and Midazolam Drug Interaction Study in Healthy Subjects

To evaluate the potential PK interaction of multiple oral doses of HCV-796 and a single oral dose of midazolam when coadministered to healthy subjects.


Eligibility Criteria:
Inclusion Criteria:

* Healthy as determined by investigator on the basis of medical history, physical examination, clinical laboratory test results, vital signs and 12-lead ECG.
Development of a Noninvasive Method of Evaluation of Pulmonary Inflammation in the Condensates of Exhaled Air

The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD, asthma, tobacco exposure. Three proteases will be analyzed, i.e. elastase, proteinase 3 and cathepsin G. Results in the condensates will be compared to those obtained in sputum.

5 groups of 20 individuals each: group 1 CF, group 2 COPD, group 3 asthma, group 4 tobacco exposure, group 5 control subjects.

Collection of exhaled condensates in all subjects and of sputum in subjects belonging to groups 1 and 2.

Clinical examination and PFTs in all patients.

Eligibility Criteria:
Inclusion criteria

* Subjects suffering from CF, COPD, asthma and tobacco exposure (groups 1 to 4) and controls (group 5)
* aged more or equal to 18
* stable disease
* able to perform PFTs
* informed consent signed
* affiliated to french social insurance

Exclusion Criteria:

* acute exacerbation of the disease during the last 2 weeks
* IV or oral steroids or antibiotics during the last 2 weeks
* hospitalization during the last 2 weeks
* colonization by S aureus methicillin resistant and/or Burkholderia cepacia
Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain

The goal of the study is to evaluate via a prospective, blinded, randomized clinical trial, whether ultrasound-guided single femoral and lateral femoral cutaneous nerve blocks with ropivacaine 0.5% with epinephrine (1:200,000) as a tracer for intravascular injection (total 30 ml) vs. saline with epinephrine (1:200,000) (total 30 ml), given just prior to same day elective hip arthroscopy, is effective in reducing acute postoperative pain (NRS scores), postoperative opiate consumption, and time to discharge from the postanesthesia care unit. Differences between groups with respect to postoperative quality of life and functional scores will also be evaluated.

The purpose of this study is to evaluate whether ultrasound (using sound waves to produce an image)-guided regional anesthesia (local numbing medicine) to the hip area given in addition to general anesthesia just prior to same day elective hip arthroscopy, is effective in reducing acute postoperative pain, and time to discharge from the post anesthesia care unit. In addition, the study aims to examine whether this regional anesthesia medication has any effect on the study subjects' use of pain medication both during and after the procedure, return to function, and quality of life in the 6 month period after the surgical procedure. Although hip arthroscopy is a routine procedure, the best method for pain control is not well established, and is the purpose of this study.

Eligibility Criteria:
Inclusion Criteria:

* \>18 year old,
* ASA physical status classification system score (ASA) \<=3
* due to undergo elective unilateral hip arthroscopy by one surgeon Dr. Nho (Co-Principal Investigator)

Exclusion Criteria:

* ASA physical status classification system score) (ASA) \>3
* history of opioid dependence or abuse
* current chronic analgesic therapy (daily use =\>20 mg oxycodone-equivalent opioid use within 2 weeks before surgery and duration of use \>=4 weeks)
* allergy to study medications (fentanyl and ropivicaine)
* any neuromuscular deficit of the ipsilateral femoral nerve or quadriceps femoris muscle (including diabetic peripheral neuropathy)
* diagnosis of hypertension and/or current treatment for hypertension
* pregnancy
Comparison of A-PRF vs Bone Wax in Hemostasis, Pain Relief and Healing Following Exodontia

The goal of this clinical trial is to compare the pain relief and healing effect of A-PRF and Bone-wax in patients having mandibular tooth-extractions. The main question\[s\] it aims to answer are:

In the perspective of improvement in pain and healing;

* Does A-PRF performs better than control group?
* Does Bone-wax performs better than control group?
* Healing index and Pain scale score Comparison of A-PRF and Bone-wax; if one is better than the other? Participants will be asked to give resoponse to a post-operative symptom severiety (PoSSe) scale. An investigator will score the patient's extraction for hemostasis and on healing index \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items\]. If there is a comparison group: Researchers will compare \[insert groups\] to see if \[insert effects\].


Eligibility Criteria:
Inclusion Criteria:

* All patients who need extraction of mandibular posterior teeth
* Overall, systemically healthy individuals (Established based on history, i.e., patients who do not take medicine for any systemic condition).
* INR within normal range.

Exclusion Criteria:

* Patients with a diagnosed systemic condition.
* Patients who are immunocompromised.
* Patients who are unwilling to participate or withdraw from the study.
* Patients who fail to report on the seventh and twenty-first post-extraction day.
* Patients with physical or mental impairments who need assistance in taking their medications.
Effect of Botulinum Toxin on Muscles of Children With Cerebral Palsy

Cerebral palsy (CP) is a group of non-progressive motor dysfunction but often changing, secondary to injury or brain abnormalities that occur in early stages of development. In children with CP, the brain injury lead to a delayed motor development in the first weeks, associated with muscular spasticity. Drug treatments include oral treatments (baclofen and tizanidine) and injectable treatments like Botox (intramuscular injection) and neurolysis with alcohol or phenol (local injection into the nerve).

Regarding botulinum toxin, there is no study questioning its effectiveness. However, no publication on the pathophysiology of human muscle of the CP child after toxin injection was found. The action of the toxin on the neuromuscular junction (NMJ) and muscle structure is unknown in children with CP.

The primary objective of this study is to describe structural abnormalities of the CP child's muscle following multiple toxin injections in terms of NMJ fragmentation and axonal sprouting.

Secondary objectives:

To evaluate the relationship between:

* The severity of the motor impairment and muscle structural abnormalities.
* The clinical measure of spasticity and muscle structural abnormalities.
* To compare the structure spastic muscles with toxin injections and spastic muscle without toxin injections

For muscles with multiple toxin injections, assessing the relationship between :

* The number of toxin injections and muscle structural abnormalities.
* The date of the first injection and muscle structural abnormalities.
* The total dose of injected toxin in the muscle and its structural abnormalities.
* The nature of the product injected in the muscle and its structural abnormalities.

This innovative study will improve the knowledge on the effects of long-term botulinum toxin injections on the muscle (and therefore its safety in usual care), on the spastic muscle NMJ of CP children, on the pathophysiology of the CP child's muscle.

All the visits all acts will be performed according to usual patient follow-up. Only a biopsy will be performed in addition, taken from an injected muscle during a planned operation. A biopsy may also be performed on a muscle without toxin injection if the act is made possible by the planned surgery. No biopsy will be made on a muscle that would not require surgery.


Eligibility Criteria:
Inclusion Criteria:

* Age Children \> 7 years and \<18 years
* With spastic cerebral palsy (all grades of the combined GMFCS
* Having an orthopedic surgical indication already planned on the lower limbs
* Receiving toxin injections
* With social security coverage
* Whose parents / holders of parental authority have signed the consent form

Exclusion Criteria:

* Patients with an evolutive CP
* Children with a baclofen pump
* Children who underwent neurotomy or functional dorsal rhizotomy, or alcohol or phenol injections
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure

Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments.

Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure (ADHF).However, chronic treatment with diuretics may limit their response and deteriorates the renal function. The hypertonic saline solution (HSS) has been proposed in recent years as an adjunctive therapy for intravenous loop diuretics to improve or restore their initial pharmacological efficacy.

In this study the investigators will evaluate the effectiveness of HSS as an adjunct to i.v. furosemide in patients admitted for AHF with renal dysfunction

In the era of the emergence of novel therapies for advanced Chronic Heart Failure , the use of HSS as a therapeutic adjunct to i.v. loop diuretics still needs to be explored on a larger scale, in particular in patients with renal dysfunction.

The objective of this study is: to evaluate the effectiveness of HSS as an adjunct to i.v. furose¬mide in patients admitted for AHF with renal dysfunction.

* Patients receive intravenous infusion of HSS (50ml of 10% NaCl) + Furosemide ( 250mg of furosemide) administered over one hour twice a day.
* Patients receive intravenous infusion of 5% Dextrose Solution (50ml of Dextrose 5%) + Furosemide (250mg of furosemide) administered over one hour twice a day.

Eligibility Criteria:
Inclusion Criteria:

* Patients with 18 years of age or older
* ADHF with congestive symptoms, laboratory(BNP) and echocardiographic criteria
* NYHA ≥II(New York Heart Association functional classification)
* Creatinine clearance≤60ml/mn (MDRD) or level of creatinine \>150 µg/ml)
* BNP levels on admission ≥400 pg/mL

Exclusion Criteria:

* age \< 18 years
* NYHA class \< II
* Patients with acute coronary syndrome, pulmonary thromboembolism, cardiac tamponade, pericarditis, those on dialysis; patients with chronic liver disease, pleuropneumonia, cerebral vascular disease, cancer, uncompensated diabetes, patients requiring pacemaker and concomitant other important comorbidity
* Signs of hemodynamic instability, respiratory distress, coma
My Mindful Moments: A Mindfulness Meditation and Digital Art Activity

The purpose of this evidence-based practice project is to evaluate the feasibility of providing a relaxation mindfulness meditation and an expressive digital arts activity among clinical staff at Dana Farber Cancer Institute .

This project provides an opportunity for patient care staff in an ambulatory oncology setting to participate in and evaluate an activity that includes a mindfulness meditation technique and an expressive digital arts activity.

This study will be conducted to evaluate the feasibility of providing a mindfulness meditation and digital imagery activity.

* The activity will include a guided mindfulness meditation and the creation of a digital image on an iPad.
* Participants will be asked to complete brief surveys before and after the intervention activity.

Eligibility Criteria:
Inclusion Criteria:

* Adults ≥18 years of age
* Currently employed at Dana Farber Cancer Institute
* Providing patient care on Yawkey

Exclusion Criteria:

* Not an employee of Dana Farber Cancer Institute
* Not providing Patient Care on Yawkey
Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)

This study will track changes in oral health in pregnant women. Subjects will be assigned to either regular oral care or advanced oral care and be given oral care products to use until they deliver. A comparison between the two groups (regular and advanced oral care) will be made to see if the oral care products impacted oral health and maternity variables.


Eligibility Criteria:
Inclusion Criteria:

* provide written informed consent prior to participation and be given a signed copy of the informed consent form;
* be at least the age of legal consent;
* be between 8 and 24 weeks of pregnancy;
* have at least 20 natural teeth;
* have moderate-to-severe gingivitis during pregnancy, including at least 30 intraoral sites with evidence of marginal gingival bleeding.

Exclusion Criteria:

* evidence of multiple gestations;
* history of HIV infection, AIDS, autoimmune disease, or diabetes other than gestational diabetes;
* indication for use of antibiotic pre-medication prior to dental procedures;
* systemic corticosteroid or immunosuppressive therapy within 1 month of Baseline;
* severe periodontal disease, rampant untreated dental caries, or other oral conditions that necessitate immediate dental care;
* ongoing dental care that in the opinion of the investigator could impact study participation;
* a history of allergies or hypersensitivity to mouth rinse products containing CPC;
* any disease or condition that in the opinion of the investigator could interfere with the safe completion of the study;
* randomization to a treatment in study 2011001 during a prior pregnancy.
Bronchospasm Associated With High Nitric Oxide

Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Eligibility Criteria:
Inclusion Criteria:

* patients with no systemic disease and registered bronchospasm during anesthesia induction

Exclusion Criteria:

* hypertension, COPD, diabetes, pregnancy
Effects of Kendall Exercise Versus Gong's Mobilization in Text Neck Syndrome. A Pilot Study

This project was a pilot randomized trial conducted to compare the effects of Kendall exercise and Gong's mobilization on pain, range of motion, function and strength in text neck syndrome so that we can have best treatment option for patients with neck pain

Non Probability Convenient sampling was done. Patients following eligibility criteria from Fatima hospital Sargodha were considered. Sample size was calculated 12.

Participants were randomly allocated in two groups equally via convenient sampling method. Baseline assessment was done initially. Group A was given Kendall exercise and Group B was given Gong's mobilization along with conventional physiotherapy treatment (hot pack). Duration of research was almost 6 months. Participants were treated 3 times a week for 4 weeks. Pre and Post treatment readings were taken in 1st session and 4th week period respectively.

Assessment was done via Numeric pain rating scale (NPRS),Neck Disability index (NDI), Universal goniometer and Modified sphygmomanometer test. All participants were provided written informed consent prior to commencement of the procedures. They were free to quit the treatment at any stage of research. Data was analyzed by using SPSS version 23.

Eligibility Criteria:
Inclusion Criteria:

* Young adults
* more than one year using a smartphone
* Using smart phone for more than 2 hours a day
* Craniovertebral angle(CVA)less than 53°
* Score of more than 3 on NPRS and more than 10 on NDI

Exclusion Criteria:

* Spinal infection or inflammatory disorder
* Neck surgery or trauma
* Torticollis, scoliosis
* Malignancy, pregnancy
* Diagnosed cases of disc prolapse, stenosis, herniation, spondylolisthesis and osteoporosis
* Current use of any medication or physical therapy treatment.
Bioequivalence Study Between Two Oral Formulations of Famotidine Tablets Under Fed Conditions

Compare the rate and extent of absorption of famotidine 40 mg tablets, administered as 1 x 40 mg tablet under fed conditions.


Eligibility Criteria:
Inclusion Criteria:

* healthy men or women 18 years of age or older
* body mass index below 30.0 kg/m2
* willing to participate and sin a copy of the informed consent form

Exclusion Criteria:

* recent history of drug or alcohol addiction or abuse
* pregnant or lactating women
* history of allergic response to heparin, famotidine, other H2-receptor antagonists, or other related drugs
* evidence of a clinically significant disorder or whose laboratory results were deemed to be clinically significant
* smoking more than 25 cigarettes per day