cyrilzakka/clinical-trials huggingface dataset:
Silesian Registry of Out-of-Hospital Cardiac Arrests

Silesian Registry of Out-of-Hospital Cardiac Arrests (SIL-OHCA) which is an initiative of the Voivodeship Rescue Service in Katowice in cooperation with the Silesian Center for Heart Diseases in Zabrze is a prospective, population-based registry of out-of-hospital cardiac arrests (OHCA). The main aim of the SIL-OHCA is to asses the frequency of OHCA in the population of Upper Silesia and analyze prognostic factors for long-term survival in patients with OHCA.


Eligibility Criteria:
Inclusion Criteria:

* Out-of-hospital cardiac arrest treated by emergency medical services of Voivodeship Rescue Service in Katowice.

Exclusion Criteria:

* none
Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines

To evaluate the impact of enteral nutrition on microaspiration of gastric content and pharyngeal secretions

A common obstacle to enteral nutrition is gastrointestinal intolerance, with regurgitations potentially responsible for gastric-content aspiration. Several studies involving technetium 99m (99mTc) labeling of gastric contents have established that gastric-fluid microaspiration is common in critically ill patients receiving both endotracheal ventilation and enteral nutrition. However, to our knowledge, no studies have specifically addressed the role for enteral nutrition in the occurrence of microaspiration. The objective of this ancillary study is to compare the frequency of gastric-content microaspiration in patients given enteral versus parenteral nutrition during the NUTRIREA2 trial. The new knowledge of risk factors for microaspiration provided by this study may help to improve strategies for preventing microaspiration and ventilator-associated pneumonia (VAP).

Eligibility Criteria:
Inclusion Criteria:

* Invasive mechanical ventilation expected to be required more than 48 hours
* Nutrition started within 24 hours after initiation of endotracheal mechanical ventilation
* Treatment with vasoactive drug administered via a central venous catheter
* Age over 18 years
* Signed information

Exclusion Criteria:

* Abdominal surgery within 1 month before inclusion
* History of esophageal, gastric, duodenal or pancreatic surgery
* Bleeding from the esophagus, stomach or bowel
Eovist vs. Dotarem Healthy Volunteer MRI

The purpose of this study is to evaluate changes in volunteer breath-holding capacity in response to gadoxetate disodium (Eovist) administration, compared with saline, and gadoterate dimeglumine (Dotarem). Healthy volunteers will be recruited from three study sites. These subjects will be given three, blinded, randomized injections while undergoing an MRI of their liver and holding their breath. During the scan, the subjects' oxygen saturation and heart rate will be closely monitored. Following the scan, the subjects will complete a questionnaire regarding the breath hold.


Eligibility Criteria:
Inclusion Criteria:

- normal renal function (serum eGFR \>60)

Exclusion Criteria:

* renal impairment
* allergy to gadolinium-based contrast
* metallic implanted devices
* claustrophobia
* pregnant and lactating females
Erector Spinae Plane Block for Postoperative Pain Management

Erector spinae plane (ESP) block is an interfacial plane block with visceral and somatic analgesic activity at paraspinal muscles. This study aims to examine the postoperative analgesic efficacy of ESP block after cesarean section (CS) with Pfannenstiel incision under spinal anesthesia.

The study included 54 patients with mild systemic disease (ASA II patients) who would undergo elective CS under spinal anesthesia. They were randomly divided into an ESP block group (Group E) and a control group (Group C). After the surgery, Group E patients underwent ultrasound-guided bilateral ESP block with 20 ml of 0.25% bupivacaine at the lateral decubitus position, while Group C received no intervention. Patients in both groups received parenteral patient-controlled analgesia. The patients' post-operative 24-hour opioid consumption, regular Visual Analogue Scale (VAS) measurements, and need for rescue analgesics were evaluated. Statistical analysis was performed using SPSS 21 program. Demographic and other data were assessed using independent samples t-test, Mann-Whitney U test, and Chi-square analysis.

Eligibility Criteria:
Inclusion Criteria:

* ASA II patients
* 18-45 years who underwent CS with Pfannenstiel incision under spinal anesthesia
* agreed to participate in the study

Exclusion Criteria:

* Patients with infection at the injection site
* Coagulopathy Allergy to amide-type local anesthetics
* History of peripheral neuropathy
* Hepatic and/or renal failure
* Refusing the procedure
* patients with heart disease
Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)

The goal of this observational study is to explore the incidence and effect on prognosis of coronary microvascular dysfunction in patients present of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) \>0.80.


Eligibility Criteria:
Inclusion Criteria:

* presence of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) \>0.80

Exclusion Criteria:

1. acute myocardial infarction
2. significant valvular heart disease
3. advanced chronic kidney disease
4. patients with significant epicardial coronary artery stenosis (\>70% in major vessels by diagnostic coronary angiography) needing percutaneous coronary intervention
5. patients unable to provide written informed consent
Symbicort in Chronic Obstruktive Pulmonary Disease

Under daily routine conditions and without any intervention by the sponsor regarding the selection of subjects, diagnostic procedures, therapeutic decisions (medicinal and non- medicinal therapy, dose, duration, etc.), routine assessments, the participating physicians (i.e.general practitioners and internists) are asked to document relevant data related to the budesonide/formoterole therapy in patients with COPD.


Eligibility Criteria:
Inclusion Criteria:

* Patients with COPD treated with budesonide/formoterol

Exclusion Criteria:

* limitiations; possible risks; warnings; contraindications mentioned in the SPC.
Effect of Irvingia Gabonensis (Bush Mango)on Parameters Associated With Metabolic Syndrome

The study investigated the use and efficacy of the seeds of African bush mango (Irvingia gabonensis)to control body weight, blood lipids and hormones in overweight and obese people.

To assess the effects of seeds of Irvingia gabonensis on body weight, fasting blood glucose, plasma total and LDL cholesterol in 102 overweight and obese participants.

The study was a 10 week randomized, double blind, placebo controlled design. participants were randomly divided into 2 groups of 51 participants each. Group 1 was the placebo group, while Group 2 was the active group. Each group received 2 daily doses of 125 mg (before meals) of either placebo or Irvingia gabonensis.

Weight as well as fasting blood was taken at baseline and at 4, 8 and 10 weeks. No major detary changes or exercises were suggested during the study period.

Eligibility Criteria:
Inclusion Criteria:

* BMI\>26

Exclusion Criteria:

* Diabetics Pregnant and lactating Participating in any other weight reducing program Smokers
Creating LASIK Flaps With the LenSx Femtosecond Laser

This will be a prospective, single-center clinical trial of up to 50 eyes of subjects scheduled to undergo LASIK surgery requiring an initial corneal flap. Subjects will be screened for eligibility.

Subjects will undergo LASIK surgery using the LenSx Laser to create the corneal flap prior to excimer laser treatment.

Subjects will be evaluated intraoperatively to assess the ease of lifting the flaps, the stromal bed quality, and the amount of opaque bubble layer. All patients will be followed with routine vision exams for 3 months postoperatively to evaluate changes in visual acuity, manifest refraction, slit lamp examination, and endothelial cell counts.


Eligibility Criteria:
Inclusion Criteria:

1. Must have myopia or hyperopia eligible for femtosecond initiated LASIK surgery
2. Must be over 18 years of age
3. Must have visual acuity correctable to at least 20/25 in both eyes
4. If subject is a contact lens wearer, discontinuation of contact lens wear prior to preoperative exam (2 weeks prior for soft contact lenses, 4 weeks prior for rigid gas permeable contact lenses, and 8 weeks prior for hard contact lenses)
5. Must be willing and able to return for scheduled follow up examinations through 3 months after surgery
6. Must sign and be given a copy of the written Informed Consent form
7. Postoperative refractive target is emmetropia

Exclusion Criteria:

1. Known sensitivity to planned study concomitant medications
2. Participation in any other ophthalmic drug or device clinical trial during the time of this clinical investigation
3. Presenting any contraindications to femtosecond initiated LASIK
4. Corneal thickness values that will result in residual bed less than 280 microns when flap resection and excimer ablation are calculated
5. Irregular astigmatism, based on Investigator's judgment
6. Undergoing monovision LASIK
7. Pregnant, lactating or plan to become pregnant during the course of this study
8. For bilateral second study eyes only: The surgeon shall not proceed with the second eye until the 1 week exam of the first eye shows no vision threatening complications.
Withings Study to Analyse the Accuracy of Screening Small Fiver Neuropathy With a Bathroom Scale

The aim of this study is to evaluate the diagnostic performance of Withings WBS08 to screen small fiber neuropathy.

Patients with neuropathy are included in hospitals. Each patient will have his neuropathy evaluated with Withings WBS08 and its reference the Sudoscan.

Eligibility Criteria:
Inclusion Criteria:

* The subject is an adult, man or woman (18 years old or more)
* Subjects affiliated or eligible to a social security system
* Subjects having expressed their consent to take part in the study
* Two type of patients are included in the study :

  * Patients having diabetes (80% of the inclusion)
  * Non diabetic patients having a lower limbs neuropathy (20% of the inclusion)

Exclusion Criteria:

* Minors under 18 years old
* Subject is pregnant or trying to get pregnant
* Subjects having a pacemaker
* Subjects having refused to give their consent
* Vulnerable subjects according to the French regulation in force:

  * Individuals deprived of liberty by a court, medical or administrative order
  * Individuals legally protected or unable to express their consent to take part in the study
  * Individuals unaffiliated to or not beneficiary of a social security system
  * Individuals who fit in multiple categories above
* Individuals linguistically or mentally unable to express their consent
* Individuals having an lower limb amputation bigger than toes
* Individuals not able to stand still for a few minutes
* Individuals under antidepressant medications
Patient and Physician Benefit/ Risk Preferences for Treatment of mPC in Hong Kong: a Discrete Choice Experiment

The objective of this study is to examine the preference weightings in term of risk/ benefit attributes of treatment in physician and prostate cancer patients from different stages of disease.


Eligibility Criteria:
Inclusion Criteria:

* aged 18 years or older,
* diagnosis of metastatic prostate cancer within 5 years,
* able to read and write,
* accepting and signing the informed consent

Exclusion Criteria:

* if patients are unable to complete the survey by themselves due to physical or psychological reasons,
* deemed ineligible by treating physicians if patients are unable to complete the survey by themselves due to physical or psychological reasons,
* deemed ineligible by treating physicians
Exogenous Effects of Standard Medical Care (Dopamine) on Motor Learning of an Upper Limb Task in Parkinson Disease

The study determines whether standard medical care (dopamine) affects learning and retention of an upper limb feeding task in people with Parkinson's disease (PD) and whether training on the feeding task generalises to performance on an untrained upper limb buttoning task. Half the participants will train on the feeding task after they have taken their first dose of dopamine for the day (i.e. "on" medication state), while the other half will train on the same feeding task before taking their first daily dose of dopamine (i.e. "off" medication state).

Parkinson disease (PD) is an age related neurodegenerative disorder with symptomatic declines in motor function due to a loss of dopaminergic neurons within the basal ganglia.

Ironically, treatment with exogenous dopamine-replacement medication (e.g. levodopa) may have positive effects on existing motor skills such as handwriting or walking, but may have detrimental effects on the learning of motor skills necessary for effective rehabilitation.

Although dopamine medications are routinely prescribed to replace lost dopamine in the sensorimotor areas of the striatum, they may actually be "overdosing" the associative striatum, a candidate neuroanatomical correlate for motor learning. To date, however, this 'overdose' hypothesis has not been widely tested, given that few studies of motor learning in PD have reported or controlled for whether individuals were tested "on" or "off" their dopamine replacement medication.

Eligibility Criteria:
Inclusion Criteria:

* Idiopathic Parkinson's disease confirmed by neurologist
* Hoehn and Yahr stages 1 to 3
* On a stable dose of antiparkinsonian medication for the past month and will continue on this regime for at least another subsequent month
* Walks unaided

Exclusion Criteria:

* Not taking dopamine replacement therapy
* With prior surgical management for PD (e.g. deep brain stimulation)
* With medication-resistant freezing of gait
* Significant cognitive impairment (Montreal Cognitive Assessment score \<18)
* Unstable medical conditions
* Other neurological conditions
* Unable to follow instructions or safely complete the training tasks
Transdiagnostic Cognitive Biomarkers

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited.

Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.

Eligibility Criteria:
Arm 1, healthy controls:

Inclusion Criteria:

* Have access to the online study platform.

Exclusion Criteria:

* under 18, non-English speaking

Arm 2: pain and depression:

Inclusion Criteria:

* Pain or depression

Exclusion Criteria:

* pregnant women
Effects of Myofascial Release With Isometric Exercises Versus Scapular Stabilization Exercise on Neck Pain in Text Neck

The objective of this study is to investigate the effects of myofascial release combined with isometrics and with scapular stabilization on neck pain, disability and ROM in young adults with text neck syndrome

Neck pain NP (pain in cervical region) has been a major issue these days related to the increased use of smartphones. A posture that has been developed by growing use of technology is a posture called the Text Neck, which has become an epidemic to the world. The text neck is a posture in which a person keeps their head down (forward head posture) to look at their device for long periods of time. There are many medications and techniques used in management of neck pain. Myofascial release has been proved to be efficacious for pain in the neck. This study is unique in that it examines the effect of myofascial therapy along with isometric exercises or scapular stabilization exercises on neck pain, disability, movements and daily life activities.

Eligibility Criteria:
Inclusion Criteria:

* Young adults including both female and male between the ages of 18 to 26 years with neck pain who were using smart phone, tablet or laptop for past six-month duration and above.
* Subjects with average 3 or more than 3 hours mobile usage and who may have 3 out of the 6 possible symptoms for text neck which include pain in neck, upper back and shoulder pain, headache as well as insomnia, tingling and numbness in the hands for more than 6 months and with a complain of pain in neck after use of mobile phones or other gadgets.
* Individuals with NDI score of minimum 30%-48% i.e., moderate disability.
* Individuals with willingness to participate in this study.

Exclusion Criteria:

* Specific causes of neck pain involving problems including neurological involvement such as myelopathy combined with weakness, sensory loss with numbness, cervical spinal stenosis and prolapse.
* Any previous neck or upper limb surgery.
* Any neurological disorders including headache and irradiated pain due to some diagnosed disease with involvement of infection and malignancy
* Cerebrovascular insufficiency, carcinoma or traumatic fractures or any chronic disease of musculoskeletal system such as polyarthritis.
* Individuals with acute pain and inflammation, torticollis, acute osteoarthritis, vertigo, heart disease, pregnancy will be excluded from this research.
Prevalence of DIAbetic RETinopathy and Impact of Genetic Factors in the Development of Diabetic Retinopathy of Patients With Type 1 and 2 Diabetes Mellitus in SlovaKia

The aim of the study is to find out prevalence and individual stages of Diabetic Retinopathy in patients with type 1 and type 2 DM verified based on complex ophthalmologic measurements in Slovak Republic. The outcome of the project will be epidemiology survey, prevalence of diabetic retinopathy (DR) and diabetic macular edema (DME) in relation to type and duration of diabetes mellitus and risk factors. Project will also identify genetic factors linked with the diseases.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years
* Signed informed consent for epidemiological research
* Signed informed consent for genetic research
* Patients with DM - type I and II regardless of the DM duration
* All DM patients must be included regardless of presence of eye complications in patient´s anamnesis or during the examination by the diabetologist Subgroups analysis
* Patients with DM - type I and II and DM duration ≥ 20 years
* Patients with DM - type I and II and DM duration \< 5 years and DR in history

Exclusion Criteria:

* Age at the time of inclusion into the \<18 years
* Gestational DM or secondary-induced diabetes
* Diabetic ketoacidosis or hyperosmolar coma
* Alcohol abuse or acute alcohol intoxication
Effect of Bile Acids on the Secretion of Satiation Peptides in Humans

The purpose of this study is do determine the functional significance of the G protein-coupled receptor TGR5 in the secretion of GI satiation peptides by using natural bile acids and oleanolic acid (triterpenoid compound of plant origin) as TGR5 agonists.

TGR5 is expressed in GLP-1-secreting cell lines and L cells from mice; gain- and loss-of-function models suggest a physiological role for TGR5 activation on GLP-1 secretion in rodents. TGR5 signaling showed improved postprandial glucose tolerance in obese mice, associated with marked postprandial GLP-1 release and insulin secretion. In contrast, TGR5-/- mice exhibited reduced glucose tolerance. In animals, TGR5 activation has been shown for natural bile acids (BAs) and triterpenoid compounds of plant origin, such as oleanolic acid (OA), suggesting a role for postprandial BAs in modulating nutrient-induced GLP-1 secretion. We therefore hypothesized that intraduodenal (ID) perfusions of TGR5 agonists (BAs and OA) stimulate the secretion of GLP-1 with respective changes in the glucose metabolism of healthy humans.

Eligibility Criteria:
Inclusion Criteria:

* Healthy subjects
* BMI of 19.0-24.5
* Age 18-40
* Stable body weight for at least 3 months

Exclusion Criteria:

* Smoking
* Substance abuse
* Regular intake of medication
* Medical of psychiatric illness
* Gastrointestinal disorders or food allergies
Determination of Prostate-specific Antigen in Capillary Blood (PSA-Cap)

The aim of the PSA-Cap study is to test the comparability of measurements of total PSA in serum from venipuncture and in serum from capillary blood using anonymized diagnostic blood samples from patients. Furthermore, a stability test of the samples is carried out after storage at room temperature for 24, 72/96 and 168 hours. Particular attention is paid to the comparability of the measurement results and the influence of the transportation time.

Interventions that are conducted with the PSA-Cap trial are the collection of capillary blood (6 droplets) from the fingertip during regular PSA testing in venous blood. PSA is measured in the serum fraction of both samples (capillary and venous) using the established routine procedure, either immediately or after simulation of common transport conditions (intermediate storage for 24; 72/96 h and 168 h at 22 °C). Control measurements include parameters of cell lysis (LDH, HIL check) and general protein stability (albumin). The patient samples used are anonymized at the source by means of a consecutive series of numbers. The anonymized result groups are compared.

Eligibility Criteria:
Inclusion Criteria:

* Men aged from 45 to 70 years
* Informed consent for PSA measurement for prostate cancer screening

Exclusion Criteria:

* Patients unable to give consent