cyrilzakka/clinical-trials huggingface dataset:
Effects of Nightshift Work and Sleep Disturbances on Erectile Function

We aim to observe the unwanted effects of nightshift work and short term insomnia on erectile function of men aged between 25 to 60 years. We will also compare the levels of serum testosterone in the target group and compare it with the ones who don't work in hightshifts.


Eligibility Criteria:
Inclusion Criteria:

* Suffering from erectile dysfunction
* Mainly psychogenic ED
* Employed

Exclusion Criteria:

* Patients with major organic causes erectile dysfunction (Radical pelvic surgery/radiation therapy, uncontrolled diabetis mellitus, uncontrolled hypertension, New York Heart Association Class 3-4 heart failure, acute coronary syndrome within 3 months, dyslipidemia)
* NEET(Not in employment, education, training) patients
Airway Injuries After Intubation Using Videolaryngoscopy Versus Direct Laryngoscopy for Adult Patients Requiring Tracheal Intubation

Abstract Background Successful tracheal intubation during general anesthesia requires a direct laryngoscope to retract the tongue and soft tissues of the mouth to achieve a line of sight for the larynx. Generally, Macintosh blade laryngoscopy is used to achieve the tracheal intubation. However, difficulties with the tracheal intubation arise the need to use alternative laryngoscopes that use digital or fiberoptic technology, to improve the larynx visibility. Among these devices, highly curved blade videolaryngoscope uses a curved blade to retract the soft tissues of floor of the mouth and transmits a video image to a screen, achieving better larynx visibility. Also, the decrease of the force in the soft tissues with videolaryngoscope could reduce airway injures.

Objectives Our primary objective is to assess whether use of videolaryngoscopy using highly curved blades for tracheal intubation in adults requiring general anesthesia reduces risk of airways injuries compared with Macintosh direct laryngoscopy. Our secondary aim is to assess postoperative satisfaction of the patients, successful intubation at the first attempt, successful global intubation, degree of larynx visibility according to classification Cormack - Lehane and time taken to perform intubation in videolaryngoscopy vs direct laryngoscopy. Finally, we assess the risk of presenting serious adverse event with the use of videolaryngoscopy compared with Macintosh laryngoscopy in hypoxemia, bradycardia and heart arrest.


Eligibility Criteria:
Inclusion Criteria:

* Over 18 years of age.
* Scheduled for a procedure or surgery that requires general anesthesia that requires orotracheal intubation.
* Scheduled for non-cardiac surgery.
* Elective surgery.

Exclusion Criteria:

* Women in pregnancy.
* Patient refuses to participate in the study before surgery.
* Patients with predictors of anticipated difficult airway.
* Head and neck surgery.
* Go to Intensive Care Unit with endotracheal intubation.
Association Between Liver Function Tests and Acute Kidney Injury in Cardiac Surgery Patients

A sudden decline in function of the kidneys is a common problem that can happen after heart surgery. It can have serious effects on a patient's recovery and long-term health, potentially leading to permanent kidney problems or heart-related issues. One of the main reasons kidney problems occurs is due to changes in blood flow caused by the heart not pumping well enough. These changes may harm the kidneys, but other organs as well such as the liver.

This study aims to find out if there is a relationship between elevated levels of liver function blood tests and the decline in kidney function.

In this study data will be retrospectively collected from the intensive care patient management system for patients admitted postoperatively to the cardiac intensive care unit (ICU) following cardiac surgery. The inclusion period spans from 2012 to 2017 (5 years) and includes about 3,500 patients.

For all included patients, retrospective data collection will include variables related to renal function, fluid balance, hemodynamics, and transaminase levels. Additionally, demographic information, surgical procedure details, comorbidities, and laboratory values will be gathered.

Cardiac surgery-associated acute kidney injury (CSA-AKI) has a multifactorial etiology influenced by non-modifiable factors such as age, comorbidities (e.g., heart failure/ejection fraction, chronic kidney disease, hypertension, diabetes), medication use (NSAIDs, ACE inhibitors/ARBs), type of surgery, duration of surgery/cardiopulmonary bypass time. Central venous pressure (CVP) can serve as a marker of venous congestion, which may contribute to the development of AKI. Venous congestion may also result in elevated transaminase levels.

The primary aim of this study is to investigate the association between postoperative transaminase elevation in the ICU and the development of AKI during the intensive care stay. Data about transaminases will be collected in the first 24 hours after ICU admission. The occurrence of AKI and its severity will be investigated within 72 hours after cardiac surgery. Furthermore, the relationship between the transaminase elevation and the severity of acute kidney injury will be examined, as well as the association between central venous presure (CVP) and transaminase levels postoperatively in the ICU.

Acute kidney injury will be defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, with severity classified based on the KDIGO staging system.

Eligibility Criteria:
Inclusion Criteria:

* 18 years old or older
* admission on intensive care after cardiac surgery
* available data about liver enzymes

Exclusion Criteria:

* chronic kidney disease with (estimated) glomerular filtration rate below 30mL/min/1.73 m2 or renal replacement therapy (RRT) dependent
* patient on extracorporal membrane oxygenator (ECMO) before or after cardiac surgery
* patient with or planned surgery for Left ventricular assist device (LVAD)
* inotropics or vasopressore before surgery
Effect of Closed Tracheal Aspiration Associated With Expiratory Pause in Pediatrics Randomized, Crossover Clinical Study

Introduction: Patients on mechanical ventilation suffer alterations in the viscoelastic characteristics of the mucus due to changes in the humidity and temperature of the inhaled air and in the respiratory volumes and flows. The literature has pointed out the use of mechanical ventilators as a tool for mobilizing secretions and closed-system aspiration associated with expiratory pause has been shown to be effective in mobilizing secretions. Objectives: To assess whether there is a difference in the mass of aspirated secretion with the application of the expiratory pause during aspiration. Methods: A crossover, randomized study. Applied to children aged 0 to 5 years and 11 months who are intubated for 24 hours with orotracheal tubes or tracheostomy. There will be an exclusion of patients who present with undrained pneumothorax, cranial hypertension or any other clinical situation that has a clinical contraindication to aspiration and patients whose parents do not agree to participate in the study. The technique will be during aspiration in the tube with where to apply or not the expiratory pause on the mechanical ventilator. This secretion will be weighed so that there is fidelity in the results.

A prospective, crossover, randomized clinical study will be carried out in the Pediatric ICU of Hospital Israelite Albert Einstein.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 0 to 5 years and 11 months who have been on invasive mechanical ventilation for more than 24 hours through an orotracheal cannula or tracheostomy will be included in the study.

Exclusion Criteria:

* Patients who present with undrained pneumothorax, cranial hypertension or any other clinical situation that has a clinical contraindication to aspiration and patients whose parents do not agree to participate in the study will be excluded from the study.
The Association Mechanism Between the Microbiome and the Development of Community Pneumonia Was Studied Based on the Analysis of Pulmonary Microbiota - Host Interaction Network

1. The difference of lung flora between the healthy group and the CAP group was compared, and the core flora involved in the development of CAP was identified.
2. To predict the metabolites associated with CAP.
3. Identification of genes related to immune response in CAP.
4. Construct the pulmonary microbiota - host interaction network with metabolites as the link.


Eligibility Criteria:
Inclusion Criteria:

* According to the CAP clinical diagnostic criteria in the Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia in Adults in China (2016 edition), cases eligible for community-acquired pneumonia were included and screened.

Exclusion Criteria:

* Alveolar lavage fluid samples without electronic bronchoscopy were excluded for mNGS etiological examination of the case.
Corever in the Treatment of Hypertension

The study primarily aims to compare the effects of two doses of Corever with placebo in patients with hypertension.

The study aims to compare the effects of two doses of Corever with placebo in patients with essential hypertension. Eligible subjects who belong to one of the following subtypes are planned to be enrolled: (1) patients with essential hypertension without drug control, or (2) uncontrolled hypertension despite treatment with up to 2 antihypertensive agents. Of note, the second category will receive randomized study treatments in addition to continuing their previous medication throughout the trial. The study also wants to investigate the safety profile of Corever during treatment period.

Eligibility Criteria:
Inclusion Criteria:

1. Patients who are 20-90 years of age
2. Patients who belong to either one of the following categories:

   With essential hypertension, as measured by office BP and are not on antihypertensive treatment at screening .

   With uncontrolled hypertension despite treatment with up to 2 antihypertensive agents, and the type and dose of the agents shall be maintained for at least 28 days prior to entering this trial.
3. Agree to and are able to follow the study procedures.
4. Understand the nature of the study, and have signed informed consent forms.

Exclusion Criteria:

1. Patients with any of the following conditions:

   * Malignant hypertension
   * Secondary hypertension
   * Average sitting SBP ≥ 180 mmHg
   * Advanced hypertensive retinopathy
   * Type 1 diabetes
   * Acute coronary syndrome
   * Clinical significant valvular disease
   * Hypertrophic cardiomyopathies
   * New York Heart Association class III -IV congestive HF
   * Second or third degree atrioventricular block or history of sick sinus syndrome unless a pacemaker is in place
   * Atrial fibrillation
   * Sinus bradycardia (\<60 bpm)
   * Asthma
   * Stroke within 3 months
   * Cancer with expected survival less than 3 years
   * A difference of \> 20 mmHg for SBP or \> 10 mmHg for DBP between arms at screening
   * Severe hepatic impairment
   * A history of a serious hypersensitivity reaction.
2. Patients with clinically significant abnormalities.
3. Patients with known contraindication to Corever.
4. Female patients who are pregnant or lactating.
5. 5. Male or female patients of child-bearing potential who do not agree to use an effective method of contraception during the study.
6. Patients is currently participating in any other clinical trial within 30 days
7. Patients need to be treated with the permitted medication.
Comparison of Ultrasound-guided Bilateral ESP Block and Wound Infiltration for Spinal Surgical Analgesia

The aim of our study is to determine the superior procedure in analgesia management by comparing the traditional wound infiltration technique with the ultrasound-guided bilateral erector spina plan block technique in spinal surgery patients.

Patients in ASA I-II-III risk group aged 18-80 who will undergo spinal surgery by Trakya University Faculty of Medicine, Brain and Nerve Surgery will be included. In this study, patient data will be collected in the form of file scanning. Intra-operative; hemodynamic data of patients; heart rate, blood pressure values, anesthetic and other drugs applied, surgery and anesthesia durations will be written from the anesthesia document after the operation is over. In the study, the application preferred by the anesthesiologist for the patient will not be intervened. The patients will be divided into three groups; wound infiltration technique was applied, ultrasound-guided bilateral erector spina plan block technique was applied and both techniques were applied together. After the operation; pain values will be calculated by VAS at the 1st, 2nd, 4th, 6th, 12th and 24th hours of the patients. The patient's length of stay, satisfaction (excellent, good, moderate, poor) and methods used for analgesia will be recorded. With the results collected in our study, it will be determined which procedure is superior in pain management for spine surgery.

Eligibility Criteria:
Inclusion Criteria:

* Undergoing elective spine surgery
* No contraindication to the technique to be applied
* Not pregnant
* Being over the age of 18

Exclusion Criteria:

* Undergoing emergency spine surgery
* There is an obstacle to the technical process to be applied
* Pregnant patients
* Patients younger than 18 years old
Neurobic Exercise Program on Cognitive Abilities

This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life.

MCI is a condition marked by a noticeable decline in cognitive functions, it is often considered a precursor to more severe forms of dementia, making early intervention crucial. Neurobic exercises are designed to stimulate the brain through multiple senses and to create a novel thinking pattern. These exercises might include activities involving sight, smell, touch, taste, and hearing, structured over six weeks to challenge the brain with non-routine tasks that promote creative thinking and memory retention.

Neurobic exercise aims to maintain strength, flexibility, and mental health as you age.

However, most research has focused on older, healthy individuals or those with chronic conditions. Studies on elderly persons with MCI are rare, and there are limited studies on the long-term effects of improved memory function. This research aims to investigate the significance of a neurobic exercise program on cognitive abilities in older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life. The findings will give insight to physiotherapists and multidisciplinary teams to improve memory retention, delay brain deterioration, and promote memory health and quality of life, making the intervention program a valuable guide.

Eligibility Criteria:
Inclusion Criteria:

* Older adults above 60
* Both male and female.
* Scored \<24 on the Montreal Cognitive Assessment (MoCA).
* Scored \>12 on the Modified Barthel ADL index (BAI).
* Ability to write and read as well as communicate well, willingness to participate in the study throughout the program

Exclusion Criteria:

* Neurological, musculoskeletal, psychiatric conditions, hearing loss and visual impairment.
* Older adults with a history of allergies to the food or flowers used in the activities.
Adolescent Vaccination Reminder Study

This protocol describes a study about vaccination uptake among adolescents. The purpose of the study is to determine whether parents who receive email reminders will be more likely to obtain Tdap (tetanus-diphtheria-acellular pertussis), HPV (human papilloma virus), meningococcal, and influenza vaccines for their adolescent children than parents who do not receive email reminders.

Adolescents are a reservoir population for a variety of vaccine preventable diseases (VPDs). Despite this, adolescent vaccination rates lag substantially behind national goals of 80% coverage for adolescent vaccines set forth by Healthy People 2020. This has been particularly the case for the vaccines most recently recommended for adolescents, such as the HPV (human papilloma virus) and seasonal influenza (flu) vaccines; national coverage levels in 2010 for HPV were 32% (for series completion among females only) and 35% for flu vaccine. Uptake levels for the two other adolescent-targeted vaccines, Tdap and meningococcal conjugate (MCV4) vaccines are currently at 69% and 63%, respectively.

A major barrier to increased adolescent vaccination levels is the lack of parental and provider recognition that an adolescent is due for vaccine doses. For providers, there are the dual challenges of getting adolescents to come in for annual preventive care visits and also minimizing "missed opportunities" for vaccination (i.e. clinical interactions with a patient where a needed vaccine could have been provided but was not). Reminder/recall systems are one mechanism to help address both of these challenges for providers while also informing parents about the need for adolescent vaccines.

Eligibility Criteria:
Inclusion Criteria:

* Parents of adolescents (Ages 11-18) have children who attend one of 4 participating pediatric practices,
* Parents are able to read and converse in English,
* Parents have an active email address that is associated with their child's medical record,
* Parents have an adolescent whose medical record can be matched with their MCIR record.

Exclusion Criteria:

* Parent age \<18 years,
* Parents have an invalid or non-working parent email address,
* Parents have opted out of email communication,
* Prisoners,
* Decisionally challenged participants.
An Extension Study to Examine the Safety and Tolerability of a New Drug in Patients With Symptoms of Overactive Bladder (OAB).

This study is designed to evaluate the safety, tolerability, and efficacy of vibegron administered once daily in participants with OAB for up to 52 weeks.


Eligibility Criteria:
Inclusion Criteria:

1. Has completed participation in study RVT-901-3003.
2. Has demonstrated ≥ 80% compliance with self-administration of Study Treatment in study RVT-901-3003.

Exclusion Criteria:

1. Has a change in history or current evidence of any clinically significant condition, therapy, lab abnormality, or other circumstance that might, in the opinion of the Investigator, confound the results of the study, interfere with the participant's ability to comply with study procedures, or make participation in the study not in the participant's best interest.
2. Has coronary or neurovascular interventions planned during the duration of the study.
3. Has uncontrolled hyperglycemia (defined as fasting blood glucose \>150 mg/dL or 8.33 mmol/L and/or non-fasting blood glucose \>200 mg/dL or 11.1 mmol/L) based on most recent available lab results in study RVT-901-3003 or, if in the opinion of the Investigator, is uncontrolled.
4. Has uncontrolled hypertension (systolic blood pressure of ≥ 180 mm Hg and/or diastolic blood pressure of ≥ 100 mm Hg) or has a resting heart rate (by pulse) \> 100 beats per minute.
5. Has clinically significant ECG abnormality which, in the opinion of the Investigator, exposes the participant to risk by participating in the study
6. Has alanine aminotransferase or aspartate aminotransferase \> 2.0 times the upper limit of normal (ULN), or bilirubin (total bilirubin) \> 1.5 x ULN (or \> 2.0 x ULN if secondary to Gilbert syndrome or pattern consistent with Gilbert syndrome) based on most recent available lab results in study RVT-901-3003.
7. Has an estimated glomerular filtration rate (eGFR) \< 30mL/min/1.73 m2 based on most recent available lab results in study RVT-901-3003.
8. Use of any prohibited medications as detailed in Section 7.7.3.
9. Plans to initiate or change the dosing of any medications listed in Section 7.7.5 during the study that in the opinion of the investigator is assessed to be clinical significant.
10. Has an allergy, intolerance, or a history of a significant clinical or laboratory adverse experience associated with any of the active or inactive components of the vibegron formulation or tolterodine formulation.
11. Is currently participating or has participated in a study with an investigational compound or device within 28 days of signing informed consent, not including participation in study RVT-901-3003.
12. Has a history of significant drug or alcohol abuse/dependence within a year of informed consent, as assessed by the investigator.
13. Has a varying sleep schedule anticipated during times when the voiding diaries are to be completed.
THYME AND CARVACROLL Nanoparticle Effect on Fungi

Invasive Aspergillosis (IA) has increasingly been recognized as an emerging disease of non-neutropenic patients and in patients admitted to the ICU, even in the absence of an apparent predisposing immune-deficiency, with incidence ranges from 0.3% to 5.8% with an overall mortality rate exceeding 80%.


Eligibility Criteria:
Inclusion Criteria:

* intensive care patients

Exclusion Criteria:

* none