cyrilzakka/clinical-trials huggingface dataset:
The Evaluation of NETs, Caspase-1 and Cytokines in ARDS Patients

1. enrollment criteria and clinical data collection: follow the principles of medical ethics, the development of inclusion and exclusion criteria, select 90 cases of ARDS patients, in the active treatment at the same time, according to the Berlin standard severity of the disease divided into mild group, moderate Group and severe group, according to the prognosis during hospitalization is divided into survival group and death group. BALF specimens were collected on the day of admission to detect the levels of NETs and alveolar macrophages. The acute and chronic health status scoring system Ⅱ (APACHEⅡ) and Murray acute lung injury score, blood routine, creatinine, urea nitrogen, fasting blood glucose, Item, mean arterial pressure, arterial blood gas analysis, oxygenation index; record the patient's mechanical ventilation time and other data;
2. Pearson linear correlation analysis of BALF in the content of NETs, alveolar macrophage coke death level was a positive correlation between the Spearman rank correlation analysis BALF in the NETs content and alveolar macrophage coke death level, APACHE Ⅱ, Murray score, creatinine, Urea nitrogen, fasting blood glucose and other indicators and ARDS severity was positively correlated;
3. To analyze the prognostic factors of different prognostic factors, to evaluate the content of NETs in BALF, the level of alveolar macrophage coke, APACHEⅡ and Murray scores were analyzed by receiver operator characteristic curve (ROC curve) Short - term survival outcome prognostic value.


Eligibility Criteria:
Inclusion Criteria:

* ARDS patients diagnosis within 3 days
* Over 18 years old but no more than 75 years old

Exclusion Criteria:

* Severe thoracic open trauma
* Pulmonary embolism
* Severe cardiovascular and cerebrovascular disease
* Endocrine system diseases
* Coagulation dysfunction
* Liver and kidney failure
* Malignant tumors
* Cardiogenic pulmonary edema
Sexual Health and Rehabilitation Online (SHAREonline)

SHAREonline is a study for young female cancer survivors that are experiencing changes in sexual health and function.

The purpose of this research is to compare two brief interventions delivered by videoconference to learn if they help women effectively manage these changes and restore sexual health and functioning.

The purpose of this research is to compare two brief interventions delivered by videoconference to learn if they help women effectively manage these changes and restore sexual health and functioning.

Participants in this study would first complete health questionnaires and then be randomized to take part in one of two types of education sessions delivered by an instructor over videoconference: 1) Group education session or 2) Individual self-management session.

About 56 women will receive the group education session and about 28 will receive the individual self-management session.

It is expected that about 84 women will take part in this study.

Eligibility Criteria:
* Female cancer survivors age 19-49
* Cancer diagnosis (except non-melanoma skin cancer) ≥ 1 year prior
* Diagnosed with first cancer ≥ age 18
* No active cancer therapy (excluding chemoprevention) in the past four months, and no further therapy planned
* Ability to read and write in English
* Bothered by significant sexual dysfunction as evidenced by a Female Sexual Functioning Index (FSFI) score of ≤26.
* Regular access to the internet

Exclusion Criteria

* Has never been sexually active
* Any impairment (e.g., hearing, visual, cognitive) that interferes with the ability to complete all study procedures independently
Spleen Preserving Surgery for Splenic Hydatidosis: A Cohort Study on Short and Long-Term Outcomes

This retrospective cohort study examines the effectiveness of minimally invasive spleen-preserving surgeries compared to total splenectomy for treating primary splenic hydatidosis in Jordan. Covering 18 patients from January 2015 to June 2021, the research highlights similar recurrence rates between both surgical approaches, emphasizing the benefits of spleen preservation in maintaining immune function and reducing septic risks, particularly in pediatric patients.

The study delves into a detailed analysis of 18 cases of primary splenic hydatid cysts treated through spleen-preserving surgeries-laparoscopic partial splenectomy, cystectomy, and cyst deroofing-augmented by albendazole therapy. It presents a comprehensive comparison based on patient demographics, symptoms, surgical details, and outcomes, including complications and recurrence rates. Findings reveal no significant statistical difference in recurrence rates between spleen-preserving methods and total splenectomy, suggesting the viability of less invasive approaches for managing this condition effectively while preserving spleen functionality and minimizing post-operative complications. The study underlines the need for individualized treatment plans and further research with larger cohorts.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients (age 14 years or older).
* Diagnosed exclusively with primary, non-recurrent splenic hydatid cysts.

Exclusion Criteria:

* Children under 14 years of age.
* Patients in late pregnancy.
* Individuals with recurrent cysts.
* Cases with extra-splenic involvement.
* Patients with less than two years of postoperative follow-up.
Dexmedetomidine on Optic Nerve Sheath Diameter

Dexmedetomidine, might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Laparoscopic lower abdominal surgery requires the Trendelenburg position with pneumoperitoneum for a prolonged time, but this can cause significant increase in intracranial pressure. Dexmedetomidine, a selective alpha2 receptor agonist might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Eligibility Criteria:
Inclusion Criteria:

* clinical diagnosis of colorectal cancer
* planed for laparoscopic low anterior resection

Exclusion Criteria:

* morbid obesity (body mass index \> 30 kg.m-2)
* history of cerebrovascular disease
* history of respiratory disease
* uncontrolled cardiovascular disease
Intracorporeal Anastomosis Accelerates Bowel Function in Comparison to Extracorporeal Anastomosis in Laparoscopic Right Hemicolectomy - a Randomized Control Trial.

Both extracorporeal and intracorporeal anastomosis in laparoscopic right hemicolectomy are renowned and performed worldwide. Many observational studies show conflicting results which method is better. This randomized control trial aimed to assess which technique is superior.


Eligibility Criteria:
Inclusion Criteria:

* malignant or benign neoplasm located in right side of the colon

Exclusion Criteria:

* stage IV disease
* conversion
* inflammatory bowel diseases
* corticosteroid intake
* immunodeficiency
* emergency surgery
* neoadjuvant therapy
* no technical possibility to perform either anastomosis
Effect of Mulligans Mobilization With Movement in Osteoarthritis Knee.

To evaluate the effect of Mulligan's mobilization with movement in osteoarthritis of the knee.

Patients with knee OA diagnosed at the orthopaedic clinic of Tumair general hospital and referred to the physiotherapy department who attended the rehabilitation centre of Majmaah university will be recruited.

Patients will be excluded if they had knee or hip injury, sensory deficits in the lower extremity, a history of lower-extremity surgery, or a history of a quadriceps or hamstring muscle injury, had low back-related leg pain, or had any contraindication to manual therapy.

The protocol was submitted to and approved by the Majmaah University Research Ethics committee (MUREC Dec.2/ COM-2021/19-3)

Participants will be requested to sign a written informed consent form approved by the institutional ethics committee. A total of 60 participants were randomly assigned to group A (experimental group): Mulligan's mobilization with movement MWM added isometric strength training, and group B (control group): Sham MWM added isometric strength training. Pre and post-test readings were taken at baseline, week 2, and week 4, respectively. The outcome measures for this study will be maximal voluntary isometric contraction of quadriceps strength (measured by ISOMOVE dynamometer), ROM, and Western Ontario and McMaster universities osteoarthritis (WOMAC) index.

Eligibility Criteria:
Inclusion Criteria:

* Patient with knee OA with radiological evidence of grade 2 or 3 of the Kellgren and Lawrence scale.
* Age between 40-65 years, unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included), and pain in and around the knee.

Exclusion Criteria:

* Patient will be excluded, if they had any deformity of the knee, hip, or back, had any central or peripheral nervous system involvement.
* They had received steroids or intra-articular injection within the previous three months, uncooperative patients.
Comparsion of Gross Motor Task Training and Trunk Trageted Training

In this study trunk, targeted training and gross motor function training were compared their effect on functional status, range of motion, and community participation of cerebral palsy children

In this project a randomized clinical trial was be conducted to determine the comparison of gross motor training technique and trunk training therapy on balance, Range of motion and community participation in children with diplegic cerebral palsy. This study aim to compare the effects of both the treatments to improve balance, quality of life and community participation. The sample was being collected according to inclusion and exclusion criteria using a convenient sampling technique within period of 6 months. The participants were be randomly allocated in two groups' .Group A received gross motor training which included sit to stand, step up and walking for 1 hour/day/3 days a week for 3 months. Group B received trunk targeted training for 1 hour/day/3 days a week for 3 months which included treadmill walking, reaching forward to the limits of stability and specific truncal activities with vibration and proprioception. The post treatment assessments was done via early assessment of balance, goniometer, and functional mobility assessment

Eligibility Criteria:
Inclusion Criteria male \& female.

* GMFCS III V
* Age 8to12 years
* Diplegic cerebral palsy
* Hypoxic brain injury
* Diagnosed with a gross motor delay by the pediatrician.

Exclusion Criteria:

* Children having a cognitive or psychiatric disorder.
* Children with known congenital limb anomaly
* Children with some chromosomal defect
The Role of Neurofeedback Training and Pain Management in Post-operative Shoulder Rehabilitation

The primary aim is to compare the efficacy of neurofeedback training (NFT) and pain management protocol (PMP) in pain reduction, restoration of shoulder function, and improved cognitive performance as the post-operative rehabilitation protocols in shoulder pain patients.

The primary aim is to compare the efficacy of neurofeedback training (NFT) and pain management protocol (PMP) in pain reduction, restoration of shoulder function, and improved cognitive performance as the post-operative rehabilitation protocols in shoulder pain patients. While the former modulates neural activity, the latter focuses on biopsychosocial aspects of pain, respectively. Also, we will measure the peripheral cytokine levels of rotator cuff injury to clarify the possible role of peripheral inflammation on central neural activities. By incorporating the behavior (both motor and cognition), peripheral inflammation, and neural activity, we believe this study would bridge the gap between mind and body as the "whole person" approach to understanding musculoskeletal pain and its appropriate therapy.

Eligibility Criteria:
Inclusion Criteria:

* Pain ≥3months and ≥3 days per week
* Pain intensity ≥ 40 (VAS scale from 0 no pain to 100 very painful)
* Participants in the neurofeedback training group and pain management group were asked not to involve other treatment when they are in the 6th-12th week intervention period.
* The surgical indication would be based on orthopedics opinions.

Exclusion Criteria:

* shoulder surgery in the prior 3 years
* osteoporotic vertebral fractures or rheumatologic diseases
* chronic wide- spread pain syndromes (fibromyalgia or chronic fatigue syndrome)
* pain at any other location in addition to shoulder pain
* Neurological disease, i.e., stroke, parkinson's disease, etc..
* Cancer
Randomized Trial of Prolonged Exposure for the Treatment of Posttraumatic Stress Disorder (PTSD)

This project will examine the impact of PE therapy for the treatment of PTSD with a sample of Latinos. The need to provide effective treatment to Spanish-speaking Latinos with PTSD is critical given the high prevalence of PTSD among Latinos. Furthermore, PTSD remains an under detected and under treated condition. Untreated PTSD has a substantial impact on health, functioning and quality of life. PE is one of the most empirically supported psychological interventions for PTSD. However, most studies that evidence the efficacy of PE have been conducted mainly with English-speaking Caucasian populations. This study has the potential to contribute to improvements in the well-being of Spanish-speaking Latinos with PTSD.


Eligibility Criteria:
Inclusion Criteria:

* 18 to \< 65 years
* Meet diagnostic criteria for PTSD
* Spanish speaker
* Allow recording of assessments and therapy

Exclusion Criteria:

* Significant current suicidal or homicidal ideation
* History of bipolar, schizophrenia or psychotic disorder
* Alcohol or drug abuse during the past three months
* Current high risk of being assaulted (i.e., living with domestic violence)
* Current psychotherapy to treat PTSD
* Unable to provide informed consent
Ending Sexual Harassment - Teaching Of Principal Investigators

The study targets three aims: Aim 1: focuses on PIs' and mentors' confidence in their ability to intervene on sexual harassment and their attitudes, perceptions, and knowledge (APK) about sexual harassment, civility, microaggressions, and unconscious bias. Aim 2: focuses on trainees' experiences of sexual harassment and microaggressions and civility, sense of belonging, well-being, productivity, and persistence in a research career. Aim 3: focuses on the culture and climate of the research learning environment.

Participants (PIs, mentors, and trainees), starting in year one, will be asked to complete a baseline survey (using the secure survey software Qualtrics) regardless of condition assignment. Then, for several months, PIs, mentors, and mentees will receive virtual educational materials (presented using a Learning Management System) appropriate to the condition to which their program has been randomized.

The initial post-survey for PIs and mentors will be shortly after the final module to evaluate short-term outcomes, encompassing attitudes, perceptions, and knowledge. Subsequently, the second post-survey will be administered one year later. Trainees will participate in three post-surveys: one immediately after, another one year later, and a final one two years later.

Eligibility Criteria:
Inclusion Criteria:

* PIs, Mentors and Trainees of T-32 Programs

Exclusion Criteria:

* People who are not PIs, Mentors and Trainees of T-32 Programs
Silicone Gel for Postsurgical Scars of the Eyelid

To determine whether silicone gel is effective at preventing or minimizing scar formation after eyelid surgery.

Upper eyelid blepharoplasty or ptosis repair is performed when the upper eyelid becomes droopy, which often occurs as a natural part of the aging process. The droopiness of the upper eyelids decreases the ability to see objects in their peripheral vision, causing functional deficits. Additionally, the droopiness can be a cosmetic concern for many. The most effective treatment option is blepharoplasty or ptosis repair.

During routine pre-operative counseling, many patients note a fear of prominent facial scarring. Different techniques have been described in the literature to minimize scarring, from steroid creams to injections to laser therapy; however, there is currently no consensus for long-term management of post-surgical eyelid scars. Specifically, there is no study examining the efficacy of topical silicone gel on eyelid scars, although a few studies have examined its efficacy on other facial scars. Silicone is proposed to aid in healing by regulating fibroblast production, reducing collagen production, and modifying expression of growth factors.

The investigator's study is designed to determine whether topical silicone may prevent significant post-operative eyelid scar formation. It may help clarify whether there is a safe and effective topical treatment for patients undergoing eyelid surgery for whom scarring or cosmesis is a concern. It is the first study of silicone gel on the eyelid and is also prospective, randomized, and double blinded.

Eligibility Criteria:
Inclusion Criteria:

* Patients will be included if they have met the criteria for undergoing upper eyelid ptosis repair or blepharoplasty. This means they have droopiness of the upper eyelids that is visually significant and limiting the patient's visual field.

Exclusion Criteria:

* Patients will be excluded if they require additional upper eyelid surgery.
High Dose Chemotherapy and Autologous Transplant for Breast Cancer

To determine survival outcomes for patients with chemosensitive brest cancer after treatment with high dose chemotherapy


Eligibility Criteria:
Inclusion Criteria:

* Stage II, III or IV breast cancer
* chemosensitive
* adequate organ function

Exclusion Criteria:

* prior transplant,
* life threatening disease
* brain metastases
Pharmacokinetics and Pharmacodynamics Study of Gemcabene in Healthy Volunteers

The purpose of this study is to evaluate the multiple-dose pharmacokinetic characteristics and pharmacologic activity of gemcabene.


Eligibility Criteria:
Inclusion Criteria:

* Good health as determined by medical history, physical examination, electrocardiogram (ECG), vital signs, and laboratory assessments
* Body weight: 60-100 kg (desirable)

Exclusion Criteria:

* Use of any medication not considered acceptable by the clinical investigators during the 14-day period before the start of the study (Day 1) ;
* Donation of a unit of blood or participation in a study of investigational or marketed drugs during the 30-day period before the start of the study (Day 1);
* If female, of childbearing potential or lactating;
* History of significant reaction to any fibrate lipid-lowering agent; and
* Significant urine collection of any drug which could interfere with the study
Pediatric Hypertension Registry (PHREG)

Pediatric hypertension is increasingly common and is a precursor for adult cardiovascular and renal disease. But even during childhood, hypertension is associated with significant morbidity, including cognitive impairment and organ damage. However, the cause of pediatric hypertension, the response to treatment, and the mechanisms behind organ damage are incompletely understood. Due to these limitations, there are no first-line medications, and treatment is often inadequate. An improved comprehension of the course of pediatric hypertension could enhance clinical care. The goal of this proposal is to create a registry of patients with hypertension to better enable research into this important disease. This patient registry will enhance the investigators ability to quickly collect and analyze data for research studies.

The investigators will include all subjects evaluated at the Brenner Children's Hospital Pediatric Nephrology clinic since January 1st, 2013 with a diagnosis of high blood pressure confirmed with three separate blood pressure measurements \>=90th percentile for age, sex, and height, or \>120/80 mmHg. The investigators will exclude patients whose initial evaluation occurred on or after their 18th birthday.

Eligibility Criteria:
Inclusion Criteria:

- Patients at one of the following : Wake Forest Baptist Health Brenner Children's Hospital Pediatric Nephrology clinic Emory University Pediatric Nephrology

* Diagnosis of hypertension confirmed with three separate blood pressure measurements
* Diagnosis after January 2013
* \>90th percentile for age, sex, height, or \>120/80.

Exclusion Criteria:

- Patients whose initial evaluation occurred on or after their 18th birthday.
The Effect of Massage on Diabetic Parameters

This research aims to investigate the effect of massage on diabetic foot risk, HbA1c and physiological parameters in individuals with type 2 diabetes. This randomized controlled experimental design will be carried out in Bolu Izzet Baysal State Hospital Köroğlu Unit Internal Medicine Polyclinic and Internal Medicine Service. According to power analysis, the minimum sample size was determined as 60 people, 30 of which were in the intervention group and 30 in the control group. Data collection tools include "Peripheral Neuropathy Sign and Symptom Score", "Ankle-Brachial Index (ABI)", "Glycemic Control Assessment (HbA1c)", "Physiological Parameters (blood pressure, heart rate and oxygen saturation)", "Inlow's 60-second Diabetic Food Screen". A total of 24 massage sessions will be applied to the intervention group, 2 times a week during the 12-week working period. Participants in the control group will continue their medical treatment protocols and massage will not be applied.


Eligibility Criteria:
Inclusion Criteria:

* Being between 30-75 years old,
* Diagnosed with diabetes at least 6 months ago,
* Absence of irritation, ulceration in the areas where the massage will be applied (hands, feet and legs),
* No problem in verbal communication,
* Being able to speak Turkish,
* No diagnosis of psychiatric disease,
* Absence of amputation in the upper and lower extremities,
* Having HbA1c test results in the last 1 week,
* Not having had Covid-19 in the last 6 months
* No experience of massage application in the last 1 month
* Willingness to participate in the research

Exclusion Criteria:

* Presence of diabetic ulcer and foot wound,
* Irritation and ulceration in the areas where the massage will be applied (hands, feet and legs),
* Having problems in verbal communication,
* Not being able to speak Turkish,
* Having a diagnosis of psychiatric illness.
Interest of a Systematic Assessment of the Treatment of LUTS in the Management of BPH

The high level of unsatisfactory outcome observed in patients treated for LUTS associated with BPH with respect to the different existing therapeutic options strongly emphasizes the need for treatment optimisation in daily practice by a careful LUTS monitoring and treatment adjustment when needed. The poorer outcome observed in patients for whom treatment has been initiated recently suggests that the duration of the disease itself may influence the patient satisfaction.To achieve this goal, we propose to systematically assess LUTS associated with BPH in patients treated for at least 6 months and to assess whether an alpha-blocker therapy initiation/modification may improve the outcome in case of persisting symptoms. We also investigate the influence of the symptom duration on the frequency of unsatisfactory outcome.


Eligibility Criteria:
Inclusion Criteria:

Patients aged 60 years or more suffering from LUTS/BPH AND medically treated for at least 6 months.

Exclusion Criteria:

* Patients with prostate cancer
* Patients requiring surgical treatment
* The absence of Lower Urinary Tract Symptoms
* Treatment initiation for less than 6 months
* Cognitive disorders or other pathologies leading to the inability to give its consent to the collection of data.
* Refusal to participate.