cyrilzakka/clinical-trials huggingface dataset:
Cardiac Rehabilitation for Patients Receiving Radiation Therapy for Thoracic Cancers

Other than optimizing medical management of cardiac risk factors, and reducing radiotherapy (RT) dose to the heart, there currently exist no interventions to mitigate or reverse the adverse cardiac effects of RT. Aerobic exercise has been demonstrated to improve patient quality of life, cardiac outcomes, and cardiorespiratory fitness in patients with cancer receiving cardiotoxic systemic therapies, but the effects of aerobic exercise on patients at high risk for radiation induced heart disease (RIHD) is unknown. In addition, home-based cardiac rehabilitation has not been tested in patients with thoracic cancers.


Eligibility Criteria:
Inclusion Criteria:

* Pathologically confirmed or radiographically diagnosed non-small cell lung cancer, small cell lung cancer, esophageal cancer, Hodgkin lymphoma, non-Hodgkin lymphoma, sarcoma, thymoma, or left-sided breast cancer.
* Planning to receive neo-adjuvant, adjuvant, or definitive radiation therapy to the thorax with curative intent.
* Willing to participate in home-based cardiac rehabilitation program and be monitored remotely via smart phone application
* Possess a smart phone or tablet capable of supporting teleHeart application
* Willing and eligible to co-enroll in the Cardiovascular Toxicity in Cancer and Improvement in Recovery (SURVIVE) Registry Study (HRPO# 201801031).
* At least 18 years of age.
* ECOG performance status ≤ 2
* Ability to understand and willingness to sign an IRB approved written informed consent document (or that of legally authorized representative, if applicable).

Exclusion Criteria:

* Presence of distant metastatic disease (except patients with lymphoma).
* Life expectancy less than 6 months
* Patient lives in skilled nursing facility, chronic care facility, nursing home, or palliative care or hospice facility
* Unable to walk
* Presence of significant cancer disease burden that would make patient unlikely to tolerate cardiac rehabilitation (CR)
* Diagnosis of primary cervical esophageal cancer.
* Presence of unstable angina.
* Recipient of heart transplant.
* Patient on cardiac transplant list or has a ventricular assist device
* Patient's baseline weight \> 300 lbs (due to weight limitations of the scale and bioelectrical impedance device)
* Pregnant and/or breastfeeding. Women of childbearing potential must have a negative pregnancy test within 14 days of study entry.
* Other medical comorbidities that make the patient unable to participate in the CR program or other assessments involved with this study.
Influence Of Nutritional Status Of Patients In The Intensive Care Output On Long Term Fate

It is established that the surviving patients after a stay in the ICU are characterized by frequent malnutrition and morbidity and mortality. The main goal of this work is to study the relationship between nutritional statuses during ICU hospitalization, whatever its determinants, and quality of life, morbidity and mortality at one year.

The hypothesis of the study is that the presence of under nutrition is responsible for a 10% increase in crude mortality at one year (which would be respectively 30% for malnourished patients and 20% for non-malnourished patients).

This is a multicenter cohort study of a 30-month follow-up on patients after a stay in ICU.

Nutritional parameters and evaluation of the quality of life will be collected during hospitalization and output during a visit to the Clinical Research Associate at 6 months and one year. Survival will be also noted. These parameters will be studied in comparative patients malnourished and non-malnourished.

Eligibility Criteria:
Inclusion Criteria:

* Patients of both sexes, age greater than or equal to 18 years

  * Hospitalized more than 72 hours in the ICU
  * Requiring at least one support organ failure:

    1. Ventilatory support (invasive or noninvasive)
    2. Administration of catecholamines
    3. Extrarenal purification whatever technique
  * Affiliated to a social security system
  * Having given free, informed written consent

Exclusion Criteria:

* Patients with end-stage disease or for which a limitation of care was decided

  * Pregnant women
  * Patients with minor or under guardianship
  * Incapacitated adults and psychiatric inpatients
Phase I/II Clinical Study of Forodesine in Japanese Recurrent/Refractory Peripheral T-cell Lymphoma Patients

Phase I portion:

To confirm safety and tolerability in recurrent/refractory peripheral T-cell lymphoma patients during repeated oral administration of forodesine 300 mg twice daily (600 mg/day) for 28 days, and determine the recommended dose. Also, to evaluate pharmacokinetics.

Phase II portion:

To evaluate the efficacy, safety, and pharmacokinetics of the recommended dosage regimen determined in the phase I portion. The primary efficacy endpoint shall be objective response rate (ORR).


Eligibility Criteria:
Inclusion Criteria:

* Japanese patients at least 20 years of age.
* Patients histologically diagnosed with peripheral T-cell lymphoma by pathological diagnosis of biopsied lesion. In this study, peripheral T-cell lymphoma is defined as the following mature T-cell/NK-cell neoplasms found in the 4th edition of the WHO Classification.
* Recurrent/refractory patients with a treatment history of at least one regimen.
* Patients with an enlarged lymph node or extranodal mass lesion clearly measurable in two perpendicular directions and greater than 1.5 cm in maximum diameter on computed tomography performed.
* Patients expected to survive for at least 3 months.
* ECOG PS 0-1.
* Patients with adequate hemopoietic efficacy, liver and kidney function.
* Patients from whom written consent has been obtained prior to study initiation.

Exclusion Criteria:

* Patients who received a chemotherapy agent or a high dose of a systemic adrenocorticosteroid within 21 days prior to initial administration of the study drug.
* Patients who received radiation therapy, phototherapy, or electron beam therapy within 21 days prior to initial administration of the study drug.
* Patients who received another study drug within 28 days prior to initial administration of the study drug.
* Patients who received antibody therapy within 100 days prior to initial administration of the study drug.
* Patients with a history of allogeneic hematopoietic stem cell transplantation. Or patients with a history of autologous hematopoietic stem cell transplantation within 100 days prior to initial administration of the study drug.
* Patients with cerebral metastasis or central nervous system lesion or a past history.
* Patients with active multiple primary cancer. Or patients with a history of a malignant neoplasm other than peripheral T-cell lymphoma within the past 5 years.
* Patients with severe cardiovascular disease.
* Patients with congenital long QT syndrome.
* Patients with QTcF \>0.48 sec.
* Patients positive for HBs antigen, HCV antibody or HIV antibody on immunological investigation. Or patients positive for either HBc antibody or HBs antibody, and showing DNA more than sensitivity in HBV-DNA assay.
* Patients positive for CMV antigen on immunological investigation.
* Patients with infectious disease requiring treatment consisting of intravenous administration of antibacterial agent, fungicide, or antiviral drug.
* Patients with interstitial pneumonia or pulmonary fibrosis, or patients judged to have insufficient pulmonary function.
Nudging Effect of Timer on Surgical Rub

To study whether a device has a nudging effect on the time spend on surgical rub.

The investigators observed the time spend on surgical rub prior to an operation. The investigators do not record names, age, sex or orther features about the health care workers who perform the surgical rub.

After 200 observations a device will be attach to the dispenser that might help increase the time spend on the surgical rub in the operathing theather. The investigatos will then make another 200 observations to see if the device cause an increase in the time spend on surgical rub.

Eligibility Criteria:
Inclusion Criteria:

• All professional health care workers, who perform surgical ru

Exclusion Criteria:

* Students and other persons at a hospital, who are not paid to be working at the hospital.
Evaluation of Surgical Techniques in Cirrhotic Patients With Ventral Hernias

ventral hernias are defects of the anterior abdominal wall, which can be congenital or acquired including epigastric, umbilical and incisional hernia. Umbilical hernias represent a common surgical problem in cirrhotic patient with ascites with 20% incidence. This work was deigned to assess outcome of different techniques of closure of ventral hernias in cirrhotic patients.

Ventral hernias are defects of the anterior abdominal wall, which can be congenital or acquired including epigastric, umbilical and incisional hernia. Incisional ventral hernia is a frequent complication of laparotomy that occurs in up to 11 % of surgical abdominal wounds

Umbilical hernia represent a common surgical problem in cirrhotic patient with ascites with 20% incidence.Factors that play role in occurance of umbilical hernia in cirrhotic patient with ascites patients is chronic increased intra-abdominal pressure, recanalization of the left umbilical vein, muscle wasting and fascial weakening from nutritional deficiencies (3,4).

Most of interventions for umbilical herniorrhaphy in cirrhotic patients with ascites done in emergency setting due to the concept of high perioperative morbidity and mortality rates in those patients. However, this strategy leads to a high risk of life-threatening complications such as incarceration and skin rupture.

Eligibility Criteria:
Inclusion Criteria:

* all cirrhotic patients with ventral hernia

Exclusion Criteria:

* hepatic encephalopathy
Detecting Early Myocardial Infiltration w/Amyloid & Light Chain Deposition Disease in Multiple Myeloma Subjects

The purpose of this study is to see if MRI techniques can be used for early evaluation of cardiac amyloidosis which is sometimes seen in individuals with multiple myeloma. Cardiac amyloidosis is a medical disorder that decreases heart function.

The purpose is to investigate the use of multiple newer CMR techniques for early evaluation of cardiac amyloidosis in multiple myeloma.

Eligibility Criteria:
Inclusion Criteria:

* All races and ethnic groups
* Male and female ages 18-80 years of age
* History of multiple myeloma
* CMR study for evaluation for cardiac amyloidosis

Exclusion Criteria:

* Pregnant women
* Subject with a metallic or electronic or other device that could be affected by the magnet
Incidence and Reasons for Preoperative Anemia in Elective Lower Joint Arthroplasty

Preoperative anemia is an independent risk factor for the need for allogeneic transfusion during surgery and increased postoperative morbidity.

Treatment of preoperative anemia is recommended. However the type of preoperative anemias in elective hip- and knee surgery has only been sparsely studied.

This observational study aims to investigate the incidence and type of anemias prior to elective hip- and knee arthroplasty.

Preoperative anemia is an independent risk factor for the need for allogeneic transfusion during surgery and increased postoperative morbidity.

In elective orthopedic surgery, international guidelines recommends treatment of preoperative anemia including the use of Iron supplements for anemias associated with iron deficiency. In addition, low iron stores in both anemic and non-anemic patients may delay postoperative hemoglobin recovery.

However, the reasons for preoperative anemia and the prevalence of patients with low iron stores have only been sparsely studied in elective hip- and knee arthroplasty.

This observational study aims to investigate the incidence and type of anemias prior to elective hip- and knee arthroplasty.

Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years
* Scheduled for elective primary hip- or knee replacement.

Exclusion Criteria:

* Not possible to obtain preoperative blood sample.
FEcal Transplant, a Hope to Eradicate Colonization of Patient Harboring eXtreme Drug Resistant Bacteria?

Our trial try to eradicate digestive tract colonization of patient harboring Extreme Drug Resistant (XDR) bacteria by performing a fecal transplantation.

Main objective:

Evaluate the eradication of the colonization of patient harboring XDR bacteria after a fecal transplantation from a healthy donor.

Secondary objectives:

English Evaluate the side effects of this procedure and tolerability. Evaluate the efficacy of the transplant if the patient is harboring glycopeptid resistant enteroccus (GRE) or carbapenem resistant enterobacteriae (CRE)

Eligibility Criteria:
Inclusion Criteria:

* Patient harboring a VRE or CRE bacteria
* Colonization confirmed by our microbiology department, including at least 3 positives swabs in the last month

Exclusion Criteria:

* Pregnant woman or breastfeeding
* immunosuppression including AIDS, corticosteroids over 60mg/day
* ongoing antibiotic treatment at the day of inclusion
* impossibility to obtain a signed consent form.
Effects of Goat Milk Yogurt on Postprandial Glycemic Responses, Arterial Blood Pressure and Energy Intake

This study investigated any potential associations between two preloads offered as snacks and postprandial glycemic response, subjective appetite and energy intake in healthy, normal weight adults

This study aimed at 1. firstly determine the glycemic index (GI) of a) goat milk yogurt b) goat milk yogurt with currants, c) currants and d) sultanina raisins, all containing 25 gr available carbohydrates and 2. test the hypothesis that a goat milk yogurt consumed as a snack before a meal, compared to milk with lactic acid would: a) have greater short-term effect on satiety measured by subsequent ad libitum meal intake, b) induce greater satiety as assessed by visual analogue scales (VAS) and c) reduce postprandial glycemic response.

Eligibility Criteria:
Inclusion Criteria:

* Healthy, non-smoking, non-diabetic men and women individuals with normal body mass index (BMI; between 18.5 and 24.9 kg/m2)

Exclusion Criteria:

* Severe chronic disease (e.g. tumors, manifest coronary heart disease, diabetes mellitus, severe kidney or liver conditions, endocrine and immunological conditions)
* Gastrointestinal disorders (e.g. chronic inflammatory bowel disease)
* Lactose intolerance
* Pregnancy
* Competitive sports
* Lactation
* Alcohol
* Drug dependency
Neurocognitive Exercise Program for Children With Attention Deficit and Hyperactivity Disorder

The effects of Neurocognitive Exercise Program (NEP) on ADHD symptoms and executive functions in children with Attention Deficit and Hyperactivity Disorder (ADHD) will be investigated using The Conners parent rating scale-revised short (CPRS-RS), Stroop Test, Wisconsin test and Y-Balance test.

The effects of Neurocognitive Exercise Program (NEP) on ADHD symptoms and executive functions in children with Attention Deficit and Hyperactivity Disorder (ADHD) will be investigated.

Material and Methods: Twenty-nine boys (14 ADHD, 15 Healthy Controls) between 7 and 13 years of age will be recruited in the study and The Conners parent rating scale-revised short (CPRS-RS), Stroop Test, Wisconsin test and Y-Balance test will be performed . All tests and measurements will be performed for ADHD group before NEP, after NEP, 6 months and 12 months. The control group will be evaluated only once.

Eligibility Criteria:
Inclusion Criteria:

* Children between 7-13 years old
* Diagnosis of ADHD given by an experienced child psychiatrist based on the 5th edition of Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 2013)

Exclusion Criteria:

* Presence of anxiety,
* Presence of depression,
* Presence of learning disability,
* Presence of intellectual disability,
* Presence of visual impairment,
* Presence of musculoskeletal or neurological disorders that may directly affect motor skill and cognition
Adrenal Venous Sampling Via an Antecubital Approach

Currently, adrenal venous sampling (AVS) serves as the gold standard for subtyping of PA. Right adrenal vein catheterization is often difficult due to unfavorable anatomy of the vein including small vein size, short length, caudal direction for the transfemoral approach, and rare drainage to the accessory hepatic vein. All of these factors limit the widespread use of this approach. Given that the right adrenal vein is angled caudally in most patients, AVS via an antecubital approach was performed since January 2012. The purpose of this multicenter retrospective study was to evaluate the safety and feasibility of AVS via the antecubital approach.

Primary aldosteronism (PA) is recognized as the most common cause of secondary hypertension, with a prevalence of approximately 10% among unselected hypertensive populations. Subtype diagnosis is crucial because unilateral primary aldosteronism can be treated by laparoscopic adrenalectomy or open surgery, which may result in a cure or significant improvement of blood pressure, thus decreases the incidence of cardio-cerebrovascular complications. Currently, adrenal venous sampling (AVS) serves as the gold standard for subtyping of PA. Given that the right adrenal vein is angled caudally in most patients, AVS via an antecubital approach was performed since January 2012 at the Fuwai Hospital. So far, there have been more than fifteen hospitals to have some experience on AVS via antecubital approach with investigators' helps. The purpose of this multicenter retrospective study was to evaluate the safety and feasibility of AVS via the antecubital approach.

Eligibility Criteria:
Inclusion Criteria:

* Consent of the principal investigator to participate to the data collection of patients with primary aldosteronism underwent AVS via antecubital approach

Exclusion Criteria:

* Refusal of the principal investigator to participate to the AVSA Study
Nails and Teeth as Biomarkers of Fluoride Exposure

To determine fluoride concentration in fingernails and estimate if there is a correlation between fluoride concentration in fingernails and fluoride concentration in toothpaste used. In addition, fluorosis of permanent incisors will be evaluated at 13 years of age and correlated with toothpaste fluoride concentration.

Toothpaste with 1000 ppm fluoride and above are more effective in a caries prevention in comparison to toothpastes with lower fluoride concentration or to placebo. Higher fluoride concentrations in toothpastes increase risk for development of tooth fluorosis. Children in first three years of life are most susceptible due to formation of permanent incisors and first molars in this period, beside younger children ingest more toothpaste compared to older children. Fluoride exposure can be measured in nails, where the average plasma fluoride concentration is reflected. The aim of our study was to determine fluoride concentration in fingernails and estimate if there is a correlation between fluoride concentration in fingernails and fluoride concentration in toothpaste used. In our study were included parents and children who had participated in previous studies from parenting class until children's 3 years of age. At that time children were randomly assigned to one of two groups, of which one was being given a toothpaste with 500 ppm fluoride and the other with 1000 ppm fluoride. Children were examined regularly until the age of 3. Children were invited to participate in another clinical examination at 4 years of age. At the time of examination parents were asked to fulfil a questionnaire about oral hygiene habits and a sample of children's fingernails were taken. A questionnaire fulfilled 200 parents, 169 children were examined, finger nail fluoride was analysed by using a gas chromatography method in 161 children. We determined that in 76 % the toothpaste chosen was not appropriate according to EAPD guidelines, 66 % parents was using toothpaste with 500 ppm fluoride for their children. The mean fingernail concentration was 1,43 ng/mg (SD = 0,08). The difference between groups using toothpastes with different fluoride concentrations, and compared with other factors, was not statistically significant. The mean concentration of fluoride in nails of our test group was low compared to reported values in similar studies and there was no significant difference between groups regarding to toothpaste used.

In addition, fluorosis of permanent incisors will be evaluated at 13 years of age and correlated with toothpaste fluoride concentration.

Eligibility Criteria:
Inclusion Criteria:

* participation in parenting class
* normal pregnancy

Exclusion Criteria:

* chronic systemic diseases
* genetic conditions
* complications at delivery
Comparison of Amniotic Fluid Index Between Before and After Maternal Position Change in Upright and Left Lateral Decubitus Position

Comparison of amniotic fluid index between before and after maternal position change in Upright and left lateral decubitus maternal position

Amniotic fluid has many important roles in fetal development such as the development of the digestive tract and respiratory system. The quantity of amniotic fluid can be measured by ultrasonography, measuring the deepest pocket in 4 quadrants of uterus then summarize as one value known as "amniotic fluid index"(AFI). The AFI has the normal range between 5-25 cm. The low AFI (\< 5 cm) is associated with abnormal fetal heart rate, and the abnormal AFI does affect to the treatment during the antepartum and intrapartum phase. However , there is the study shown that when compared to the single deepest pocket (SDP) , AFI could detect the oligohydramnios more which might led to the unnecessary labor induction or operative delivery without the significant change of perinatal outcome. To increase the accuracy of AFI, we theorize that maternal position change might affect the amniotic fluid position which would increase the visual of the amniotic fluid as well.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women age 20-34 years whose gestational age was confirmed by ultrasonography before 24 weeks of gestation

Exclusion Criteria:

* Pregnant women with multifetal pregnancy
* Pregnant women who have underlying disease
* Pregnant women who have the history of premature rupture of amniotic membrane
* Pregnant women who have amniotic fluid index below 5 cm (oligohydramnios)
* Pregnant women who have amniotic fluid index more than 25 cm (polyhydramnios)
* Pregnant women whose her baby has the fetal anomaly
Methodology Validation: Correlating Adherent Scalp Flaking Score (ASFS) With Phototrichogram for Scalp Dandruff Evaluation in Adult Subjects

This study aims to validate methods for assessing scalp hair dandruff by comparing three evaluation techniques: the Adherent Scalp Flaking Score (ASFS), Phototrichogram, and 60-second hair combing.

These assessments will be conducted before and after hair wash interventions on adult human subjects to evaluate adherent and non-adherent scalp flakes. By comparing the results of these evaluations, the study aims to determine the consistency and reliability of each method in assessing the presence and severity of dandruff. Establishing correlation between these assessment techniques is essential for validating their usefulness in evaluating the effectiveness of hair care products and treatments in reducing scalp dandruff. This research aims to improve the accuracy and reliability of dandruff evaluation methods, benefiting both dermatological research and clinical practice in managing this prevalent condition.


Eligibility Criteria:
Inclusion Criteria:

* Age between 18 and 55 years (both inclusive).
* Good general health as determined from recent medical history.
* No previous history of adverse skin conditions, and not under any medication likely to interfere with the results.

Exclusion Criteria:

* Non-willing subjects and subjects with a history of allergies or specific allergic reactions upon using dermatological/cosmetic products will not be included.