cyrilzakka/clinical-trials huggingface dataset:
Admission Glucose ICU Study

Determine if routine BG testing at the time of ICU admission is being done on all patients, irrespective of a prior diagnosis of diabetes mellitus, and whether it provides clinically important information.

This prospective, observational study was performed in the medical-surgical ICU of a single hospital within a large multi-specialty healthcare system.

It was determined that it was not standard care to do glucose testing on all patients admitted to medical/surgical ICU's who did not have diagnosed diabetes and varied widely with the admitting service.

The primary objective of the study was to assess the availability and clinical value of blood glucose testing at the time of ICU admission after testing was implemented as routine care in the ICU.

Eligibility Criteria:
Inclusion Criteria:

* ICU Admission

Exclusion Criteria:

* \< 18 years of age
Staphylococcus Aureus Bacteremia: Impact of an Intervention Program in Improving the Clinical Management and Review of the Clinical and Molecular Epidemiology

Staphylococcus aureus bacteremia: impact of an intervention program in improving the clinical management and review of the clinical and molecular epidemiology.


Eligibility Criteria:
Inclusion Criteria:

* Patients over 14
* Clinical significant bacteremia by S. aureus
* Patient hospitalized

Exclusion Criteria:

* Non clinical significant bacteremia
* Ambulatory patient
* End-of-life patients
Relation Between Maternal Iodine Status and Prenatal Foetal Thyroid Dimension

Mother with severe Iodine deficiency are more likely to have neonates with further poor mental development . In order to select population which could benefit from iodine supplementation, ioduria has been tested but cannot be routinely practised. Strong background data suggest that iodine status could be antenatally correlated with foetal thyroid volume. The aim of that study is to examine correlation between these two parameter in a population of 130 healthy pregnant women.

Iodine is an essential element in thyroid homeostasis, particularly in pregnant woman and her fetus. Various studies have clearly shown that antenatal thyroid disorders at both the mother and the fetus could cause in extreme situations of neurological consequences.

At a broader scale, subtle alterations of thyroid hormone balance has been implicated in developmental delays and deviations of the IQ bell curve in newborn infants of mothers with elevated TSH.

The clinical implications of these basic data and public health are yet to confirm.

It has been clearly established that there is a moderate iodine deficiency in France with a decreasing gradient from west to east. In the Ile de France, there is a moderate iodine deficiency, this has led some teams to propose a systematic supplementation of all women in iodine.

One way to target women who really need supplements systematic determination of urinary iodine tongue; this assay is reliable but is difficult to implement in an ad hoc practice at the individual level.

Our team has expertise in the field of fetal thyroid, particularly in its sonographic and reference curves of the perimeter and diameter of the thyroid are now clearly established reliably.

Knowing that iodine deficiency is causing a decline in maternal urine iodine with a phenomenon goitrigénèse and biological hypothyroidism and that some studies have shown that neonatal thyroid volumes were higher in iodine deficient mothers . We postulate that the measurement of fetal thyroid by our criteria can be correlated with maternal urinary iodine.

If this were the case, we will have a simple test to identify iodine supplementation in pregnant women.

Eligibility Criteria:
Inclusion Criteria:

* normal single pregnancy in a healthy volunteer

Exclusion Criteria:

* any associated disease
* pertubation of thyroid status at 12 GA
Skin Sterility After Ethyl-Chloride Spray

The aim of this study is to investigate sterility of ethyl-chloride topical anesthetic spray when used prior to an injection. The hypothesis is that the spray does not change the sterility of the injection site after skin is prepped.

This is an IRB-approved, prospective, blinded, controlled study. In the first set of experiments, skin sterility is assessed. Healthy adult subjects are prepared for mock injections of shoulders and knees. No injection is performed. Each site has a set of 3 skin cultures: 1) prior to the alcohol prep (pre-prep), 2) post-alcohol prep (pre-spray), and 3) after ethyl-chloride was sprayed on the site (post-spray). In the second set of experiments, sterility of ethyl chloride is tested directly by culturing the liquid from the spray bottles.

Eligibility Criteria:
Inclusion Criteria:

* age -- 18-85
* healthy skin at shoulder and knee area

Exclusion Criteria:

* allergy to ethyl-chloride
* skin lesions at shoulder or knee
The Protrieve PROTECTOR Study

The Protrieve PROTECTOR Study is a prospective, single-arm, multicenter study of the Protrieve Sheath.

The primary study objective is to evaluate the safety and effectiveness of the Protrieve Sheath in preventing clinically significant intraprocedural pulmonary embolism by providing embolic protection in the IVC during thrombectomy procedures to treat DVT.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥ 18 years
2. Planned intervention for DVT presenting with one or more of the following characteristics indicative of elevated risk for PE:

   1. Bilateral iliofemoral DVT
   2. Clot extending into or located in the IVC
   3. In-stent thrombosis
   4. Presence of thrombosed IVC filter
   5. Other features that the investigator deems put the subject at elevated risk for thromboembolism
3. Willing and able to provide informed consent

Exclusion Criteria:

1. Current symptomatic PE
2. Known anatomic inability to place Protrieve device via jugular vein access site
3. Presence of clot extending to the IVC-Right Atrial junction or in the SVC
4. Subject is pregnant
5. Severe allergy to iodinated contrast agents that cannot be mitigated
6. INR \> 1.7 if not currently on anticoagulation therapy, platelets \< 50,000/μl which cannot be corrected prior to enrollment, or Hemoglobin \< 8.0 g/dL
7. Severe renal impairment in patients who are not yet on dialysis that in the Investigator's discretion would pose risk to the patient with the use of marketed contrast agents
8. Subject is participating in another study that may interfere with this study
9. Subject has any condition for which, in the opinion of the Investigator, participation would not be in the best interest of the subject
10. Subject has previously completed or withdrawn from this study
11. Limb-threatening circulatory compromise (e.g., phlegmasia)
12. Uncontrolled severe hypertension on repeated readings (systolic \> 180mmHg or diastolic \> 105mmHg)
13. Severe allergy, hypersensitivity to, or thrombocytopenia from heparin
14. Inability to provide therapeutic anticoagulation per Investigator discretion
15. Known hypercoagulable states that, in the opinion of the Investigator, cannot be medically managed throughout the study period
16. Inability to be a candidate for intervention due to medical or technical reasons based on physician judgement
Epidemiological Data of Patients Consulted to Kayseri City Hospital Physical Therapy Clinic in the 2023 Kahramanmaraş Earthquake

The quality of life of people after the earthquake is significantly affected. In particular, adequate and correct management of the damage caused by trauma on the human body is very important to reduce disability. Epidemiological information about the injury pattern from past earthquakes is crucial for preparedness and effective response to potential earthquakes in regions where resources are scarce. Thanks to the epidemiological data obtained from post-earthquake injury patterns, hospitals can be prepared for possible earthquakes, and disability and mortality can be reduced.

Although many earthquake victims suffer injuries that require treatment, there are large gaps in knowledge regarding the epidemiology of earthquakes. It is essential to evaluate the data collected after the earthquake in the planning phase of the health demands of the earthquake area. Epidemiological studies on earthquakes guide the planning and organization of health services for hospitals located in and around the earthquake area. By knowing the injury patterns that will occur after the earthquake, the effectiveness of the early and specific treatments to be applied to the earthquake victims can be increased significantly. In this way, complications, disability and mortality rates that may occur in future natural disasters can be reduced. The aim of this study is to record the injury patterns and treatments of the patients who were consulted to the physical therapy and rehabilitation clinic after the 2023 Kahramanmaraş earthquake in our country, which is an earthquake zone, and to ensure that the physical therapy physicians meet the possible earthquakes in a more knowledgeable, experienced and prepared manner.


Eligibility Criteria:
Inclusion Criteria:

* All age group patients, male and female, who had earthquake-related injuries and were consulted to the physical therapy unit were included in our study. Our study included both earthquake survivors who were consulted before the study (their files were scanned retrospectively) and newly registered patients (by obtaining voluntary consent form signatures).

Exclusion Criteria:

-
TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms

The overarching goals of this study are to employ cognitive testing to understand how transcranial direct current stimulation (tDCS), when used concurrently with cognitive training tasks, can affect cognitive impairment symptoms in individuals with long COVID, or post-acute sequelae SARS-CoV-2 infection (PASC), and to examine variability in response between active and sham tDCS treatment groups.


Eligibility Criteria:
Inclusion Criteria:

* Ability to provide consent and comply with study procedures
* Age 18 to 60 years old
* Estimated IQ within the specified range (70 \&lt;= IQ E \&lt;= 115)
* Current post-acute sequelae SARS-CoV-2 infection (PASC) as defined by the National Center for Health Statistics post-COVID-19 conditions survey ((Long COVID 2022), including impaired cognition symptoms, for at least 3 months post-infection
* Ability to participate in four weekly 40' training sessions over four weeks and participate in two assessments
* English speaking

Exclusion Criteria:

* Any medical condition or treatment with neurological sequelae (e.g. stroke, tumor, loss of consciousness \&gt;30 min, concussion involving hospital admission, HIV)
* Contraindications for tDCS (e.g. history of seizures)
* Five or more sessions of neuromodulation (such as tDCS) or cognitive training in the past 6 months
Effects of Lutein and Zeaxanthin Supplementation on Early Age-related Macular Degeneration

This study is to investigate the protective effects of supplemental lutein and zeaxanthin on early age-related macular degeneration (AMD) patients in China.

Early age-related macular degeneration (AMD) is an early hallmark of irreversible vision impairment accompanying with senescence of macular. Given the fact in treatment, prevention strategy is thought to be an efficient and robust approach to diminish early AMD patients in low-income countries, however, feasible cocktail provision in most developing nations remain mysteries. Here we proposed an effective cocktail treatment with different amounts of lutein and zeaxanthin could increase the macular pigment optical density (MPOD) and serum xanthophylls concentrations among randomized Chinese AMD patients; and might improve visual function measured by visual performance indices such as best-spectacle corrected visual acuity (BSCVA), contrast sensitivity (CSF), flash recovery time (FRT), multifocal electroretinogram (mfERG) and microperimetry.

Eligibility Criteria:
Inclusion Criteria:

* aged over 50 years, Chinese of the Han nationality
* diagnosed as age-related macular degeneration
* did not take lutein or zeaxanthin supplements in the past half a year
* good general health
* corrected visual acuity above 0.25 (20/80)
* did not take optical laser or medical treatments

Exclusion Criteria:

* had other ocular diseases, such as glaucoma, macular pucker, optic neuropathy, diabetic retinopathy etc.
* had nervous system diseases, stroke, Type I diabetes
* had diseases effected nutrients absorption, such as Crohn' s disease
* had turbid ocular media or transplanted intraocular lenses
* reported abnormal digestive condition
Remineralization of Molar Incisor Hypomineralization (MIH) With a Hydroxyapatite Toothpaste

This study tests the remineralization of donor teeth (donorMIH) in situ in participants using 10% hydroxyapatite (HAP) toothpaste and sodium fluoride toothpaste.

Prior to each 2-week treatment phase, subjects will complete a 1-week washout period. Following the washout period, the intra-oral appliance containing a donorMIH tooth block will be fitted to each subject by a qualified dentist. Immediately after fitting of the first appliance (on day 1 of the first treatment phase), each subject will receive a soft bristled manual toothbrush for use throughout the duration of the study and a toothpaste according to the treatment phase. Subjects will be instructed to brush their teeth with the appliance in the mouth, two times daily, for 3 minutes on each brushing episode, in the morning after breakfast and last thing before bed, then rinsing with 10 ml of water. Over the study period, all subjects will maintain their normal dietary habits.

A 7-day washout period without an appliance will follow. After completion of the second washout period, subjects will return to the clinic, and the appliance, with another MIH-bearing tooth blocks mounted, will be fitted to the subject for the phase 2 treatment period. This procedure will then be repeated until the 2-week treatment phase is completed, and each subject has gone through the two arms of the study.

Eligibility Criteria:
Inclusion Criteria:

* 18-60 years of age
* Good general health
* No known history of allergy to personal care/consumer products
* Minimum of 20 natural uncrowned teeth (excluding third molars)
* Normal salivary flow rate (stimulated and unstimulated flow of ≥0.7 ml/min and ≥0.2 ml/min respectively
* Able to consent
* Availability throughout entire study
* Willing to wear intra-oral appliance 24 hours per day
* Willing to use only assigned products for oral hygiene for duration of study

Exclusion Criteria:

* Advanced periodontal disease
* A medical condition that requires pre-medication prior to dental visits/procedures
* Impaired salivary function
* Orthodontic retainer(s)
* Too few teeth to secure the oral appliance
* Disease of the soft or hard oral tissues
* Use of drugs that can affect salivary flow
* Use of antibiotics one month prior to or during this study
* Participation in another clinical study one week prior to the start of washout period or during this study period
* Allergic hisotry to common toothpaste ingredients
* Compromised immune system (HIV, AIDS, Immunosuppressive drug therapy)
Davallia Divaricata BL: The Use of Traditional Chinese Native Medicine for Osteoporosis

We, the investigators at National Taiwan University Hospital, have determined the therapeutic and toxic effects of the traditional herb on the ovariectomized Wistar rat.

The final years will determine its effects on the therapy of women who are over 45 years old and postmenopausal with osteoporosis.

Research of this traditional chinese clinical medicine, Gusuibu, curative effect is planned for three years time. The entire study aims to evaluate the effect of the traditional chinese medicine on postmenopausal osteoporosis as well as the possible side effects on the experimental animal and the human body. All subjects were postmenopausal women with established osteoporosis.

Eligibility Criteria:
Inclusion Criteria:

* Postmenopausal osteoporosis

Exclusion Criteria:

* Insulin dependent diabetes
Efficacy and Safety of DA-3002 in Children With Idiopathic Short Stature

Growth hormone therapy will improve the height of idiopathic short statured children. DA-3002(Recombinant Human Growth hormone)treated group for 26 weeks, will be compared to non-treatment group in efficacy and safety.


Eligibility Criteria:
Inclusion Criteria:

* Chronological Age ≥ 4
* Bone Age \<11 (for girls) and \<13 (for boys)
* Height \<3rd percentile for age
* normal thyroid function

Exclusion Criteria:

* endocrine and/or metabolic disorders
* growth failure caused by other disorders
* previous use of drugs that could interfere with Growth Hormone treatment
Childhood Obesity Prevention Trough Education Innovation in Primary School: A Quasi-experimental Trial

This study evaluates the effect of the education innovation program"chiquichefs" on anthropometric variables, quality of life and nutritional habits in an elementary school children. Compared with a control group of the same age but in another school.

Childhood obesity is recognized as both the most prevalent health problem in the western world and as a global epidemic. It has an multifactorial aetiology. Obesity in children has been attributed to decrease in physical activity and the overconsumption of cheap energy dense food.

Spain has one of the highest prevalence rates of overweight and obese children among OECD countries.

Health promotion and prevention strategies in community settings are in general most effective where they engage with social networks and build social capital to enable community ownership and embedding strategies. This is particularly the case for health promotion at primary school, as social institutions within a community setting that represent a complex system with direct an indirect community relationship and social networks.

One of the best methods to prevent childhood obesity is to follow the Mediterranean diet. Especially in Mediterranean countries for the ease of access to essential products of this diet.

Chiquichefs is a methodology of project-based learning using healthy through cooking as the core of the curriculum, so children learn the academic content through cooking workshop in their school.

A quasi-experimental study was developed, for which children of the intervention schools (n = 75) in a public spanish school is compared with children of a control schools (n = 75) in the same region.

The interventions started in october 2015. In the intervention school, a whole-school approach named "chiquichefs" is implemented with the aim of improving culinary skills and dietary behaviour.

The "chiquichefs" project ideas is to make the kitchen the central pillar of the curriculum for several years. So children will learn to cook during school hours -- and not as an after-school activity -- and along the way they will also be taught the core content.

They'll do maths counting chick peas, study the recipes of literature, the geography of food, work out the boiling point of soups and learn the anatomy of cattle.

With this project, we aim to deliver the core educational requirements, teach kids to cook and lay the foundations for them to benefit from a healthier diet throughout their lives. We're going conduct a scientific study to measure the impact on the children's health and education in the hope of eventually persuading others to follow our lead.

We are going to measure the anthropometric variables, the adherence to mediterranean diet and the quality of life of all participants before and after the "chiquichefs" program.

Eligibility Criteria:
Inclusion Criteria:

* All children and their caregivers enrolled at the participating schools and that agree to sign informed consent.

Exclusion Criteria:

* None except not agreement to sign the informed consent.
Cardiac Resynchronization Therapy Modular Registry

The purpose of the study is to collect some parameters (clinical, electrical, radiographic, echocardiographic and ECG) able to predict response to cardiac resynchronization therapy.

Heart failure is a complex clinical syndrome characterized by a high prevalence and incidence in populations at greatest risk and, therefore, with a significant social and economic impact. Randomized clinical trials, meta-analyzes, observational studies and controlled trials clearly demonstrated that the neuro-hormonal therapy is highly effective in reducing mortality, hospitalization and improving quality of life. In recent years the electrical therapy is playing an increasingly important role in the treatment of patients with chronic heart failure. Such importance is mainly due to the possibility of preventing sudden cardiac death by implanting an ICD and to correct the deleterious effects of electrical dyssynchrony and / or left ventricular mechanics by CRT. The CRT has proven an effective tool in reducing mortality, reducing symptoms and improving quality of life in patients already receiving optimal medical therapy. Despite the undoubted benefits that the electrical treatment has added to conventional medical therapy, a high percentage of patients does not benefit in terms of clinical and echocardiographic. The identification of non-responders to CRT is crucial in order not to submit the patients to an unnecessary and costly device whose electrical therapy proves to be ineffective. The reason for lack of response is still unclear but factors such as lead placement, device-settings and the degree of dyssynchrony before implant seems to be important. The purpose of the study is to collect some parameters (clinical, electrical, radiographic, echocardiographic and ECG) able to predict response to cardiac resynchronization therapy.

Eligibility Criteria:
Inclusion Criteria:

* Chronic symptomatic HF despite stable, optimal drug therapy
* Indication for a cardiac resynchronisation device with or without defibrillator backup according to current guidelines
* Patients implanted with cardiac resynchronization device

Exclusion Criteria:

* Patients participating in other studies that clearly impact the clinical practice of the center
* Patients who are unable to provide informed consent
* Patients who can not perform follow-up in the center