cyrilzakka/clinical-trials huggingface dataset:
A Comparison of Tracheal Intubation Using the Totaltrack vs the Airtraq Laryngoscope in Difficult Airway Management

Endotracheal intubation is usually required to allow unrestricted surgical approach. The Macintosh laryngoscope is the standard method. However in certain situations as difficult airway this technique is ineffective and poorly tolerated by the patient. Fiberoptic intubation is the gold standard in this scenario, however sometimes it is not possible due to failure or unavailability, so alternatives are needed. The TotalTrack (MedComflow SA, Barcelona, Spain) and the Airtraq (Prodol Meditec, Vizcaya, España) been designed specifically for the airway management. However, despite their use in clinical practice, there are no comparative studies.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing elective general anesthesia requiring OTI.
* Patients duly informed and they have signed the informed consent during the pre-anesthetic consultation, or be sought after due meditation, expressing its consent to the inclusion in the study.
* Age ≥18 years.
* ASA I-III.
* Sufficient intellectual capacity to understand the procedure and equipment used.
* Predictors of difficult airway (Mallampati class III or IV; thyromental distance \<6 cm, sternomental distance \<12.5 cm, interincisal distance\<4.0 cm, bite test II or III, cervical mobility \<90 ° or history of difficult intubation).
* Thyroid surgery or present pharyngolaryngeal, glottic or cervical pathology
* BMI \>30kg / m2
* Not presenting risk factors for aspiration
* Not presenting respiratory disease, coronary or cerebral vascular.
* Do not have a preoperative sore throat

Exclusion Criteria:

* Failure to meet the above criteria
* Pregnancy
* Allergy to any drug included in the protocol.
Long-term Follow-up in Patients Affected With Acrofacial Vitiligo

Acrofacial vitiligo is a clinical form of vitiligo characterized by macules in distal digits, periorificial-facial and ano-genital areas. Vitiligo European Task Force classifies vitiligo as generalized or localized; generalized vitiligo may be further sub-divided into acrofacial, vulgaris and universalis, and localized vitiligo, into segmental and focal. Some authors do not believe that acrofacial is a real vitiligo clinical form, considering it as an initial form of vulgaris vitiligo. The aim of this study is to follow early- diagnosed acrofacial patients during ten years in order to define if these patients will maintain this clinical form or will evolute to a more severe clinical form.


Eligibility Criteria:
Inclusion Criteria:

1. Patients of both genders, aged older than years, able to understand and provide written informed consent and able to allow compliance at the treatment and the requirements of the protocol;
2. Presence of acrofacial vitiligo;
3. Able to comprehend and willing to provide written informed consent in accordance with institutional and regulatory guidelines.

Exclusion Criteria:

1- Subjects assessed as not suitable for the study in the opinion of the investigator

2 -Inability to complete survey
Evaluation of the Occurrence of Acute Complications Caused by a Central Venous Catheter Placement

It is an observational, prospective, monocentric study. The purpose of the study is to assess the acute complications rate caused by a central venous catheter placement.

All the patients who require a central venous placement could be enrolled in the study.

The study will not change the usual practice. The placement will be on day 1 and patients will be contacted by phone on day 7 to identify potential complications and to assess pain.

Anaesthesia staff will keep patients under surveillance to control the absence of late complications.


Eligibility Criteria:
Inclusion Criteria:

* Age \>= 18.
* Patient who requires the placement of a central venous catheter (a portacath (PAC), a peripherally inserted central catheter (PICC) or a tunnelled catheter).
* Patient able to understand, read and write French.
* Mandatory affiliation with a health insurance system.

Exclusion Criteria:

* Active infection at placement of the central venous catheter.
* Patient who can't be contacted by phone.
* Patient who is likely to have a femoral venous catheter placement.
Clinical Study to Evaluate the Possible Efficacy of Nifuroxazide in Patient With Ulcerative Colitis

Ulcerative colitis (UC) is one of the most common types of chronic and non-specific inflammatory bowel diseases (IBD). It is characterized by cytokine-induced continuous and diffuse inflammatory infiltrations into the rectum's mucosa and extends proximally to the colon. Patients with UC predominantly have bloody diarrhea, abdominal pain, fecal urgency, and tenesmus, which extremely alters their quality of life.

Although the precise pathological mechanism of UC remains unclear, several studies have been outlined many factors that could involve in the pathogenesis of UC, including, but not limited to, initiation of the inflammatory response, disruption of oxidant/antioxidant status, dysregulation of the immune response, alteration of gut microbiota, and delaying epithelial barrier healing. Loss of intestinal barrier function and dysregulated immune response are the key events during colitis development


Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years
* Both male and female will be
* Mild and moderate UC patients diagnosed and confirmed by endoscope

Exclusion Criteria:

* Breast feeding
* Significant liver and kidney function abnormalities
* Colorectal cancer patients
* Other inflammatory bowel diseases (CD).
* Patients with severe UC
* Patients taking rectal or systemic steroids
* Patients taking immunosuppressives or biological therapies
* Addiction to alcohol and / or drugs
* Known allergy to the Fenofibrate
Immune Dysfunction in Critical Illness: Utility of a Panel of Genes and Molecules Involved in the Immunological Synapse

Critical illnesses represent a significant physiological assault that triggers changes in the patient's immune system, resulting in an immunopotentiating response (systemic inflammatory response syndrome, SIRS) and an immunosuppressive response (compensatory anti-inflammatory response syndrome, CARS). The balance between SIRS and CARS is essential for the patient to return to a state of immune homeostasis and accelerate the healing process. However, when CARS is disproportionately intense, it leads to a state of immunoparalysis, which predisposes the patient to vulnerability to opportunistic infections, associated with a peak in late mortality. The majority of patients admitted to the ICU are considered immunocompetent. However, the investigators suspect that a significant proportion of them exhibit predominance of CARS and a state of functional immunosuppression. There is currently no diagnostic test to determine whether a patient is functionally immunocompetent at a specific point in time.

The goal of this observational study is to learn about the immune system dysfunction occurring in critical illness. The main questions it aims to answer are:

* What is the prevalence of immune system dysfunction in critical illness?
* Does immune system dysfunction affect multiple organ failure trajectory and mortality in critical illness?
* Is immune system dysfunction related to an increased risk of opportunistic hospital-acquired infections in critical illness?
* Is immune system dysfunction related to age, fragility, nutritional status or previous comorbidities in critical illness?

To answer these questions, the investigators will prospectively study a population of critically ill patients, defined by the presence of organ failure. The investigators will analyse a panel of genes and molecules involved in immunological synapse, using peripheral blood samples at different moments of the evolution of critical illness. Based on the analysis, the investigators will classify the patients' functional immune status and correlate it with the outcomes.


Eligibility Criteria:
Inclusion Criteria:

* Failure of one or more organs, assessed by a Sequential Organ Failure Assessment Score (SOFA) ≥4 within the first 24 hours of admission to the Intensive Care Unit (ICU). At least one of the physiological systems involved must be in the category of organ failure and, therefore, score ≥3.
* Informed consent to participate in the study.
* Age equal to or greater than 18 years.

Exclusion Criteria:

* Pharmacological immunosuppression within the 3 months prior to the current admission date, including treatment with corticosteroids, immunosuppressive drugs (conventional or biological), or chemotherapy.
* Immunodeficiency.
* Age under 18 years.
* Absence of consent to participate in the study.
Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles

This study aimed to explore the influence of organic anion transporting polypeptide1B1 (OATP1B1) genotype on pharmacokinetics, lipid lowering effect and lipid profiles after rosuvastatin administration.

Open, one arm, single sequence study for healthy volunteers are investigated. Thirty four subjects may be enrolled.

Rosuvastatin are administered once a day for 21 days. Before and after rosuvastatin administration, PK, PD and lipid profiles are investigated.

Eligibility Criteria:
Inclusion Criteria:

* Age: Between 20 to 50 years of age, inclusive (age based on the date to give the informed consent)
* Weight: Over 55 kg, within ±20% of ideal body weight
* Must be reliable and willing to make themselves available during the study period
* Must be willing to give blood sample for genotyping

Exclusion Criteria:

* History of significant clinical illness needs medical caution, including cardiovascular, immunologic, hematologic, neuropsychiatric, respiratory, gastrointestinal, hepatic, or renal disease or other chronic disease
* History of a significant surgical resection of gastrointestinal tract except appendectomy
* History or evidence of drug abuse
* Use any medication during the last 14 days period before first dosing
* Hypersensitivity to HMG-CoA reductase inhibitor
* Judged to be inappropriate for the study by the investigator
The Turkish Version of The Active-Q: Physical Activity Questionnaire

The investigators think that "The Active-Q: Physical Activity Questionnaire" will help physiotherapists and other health professionals in the field and in the field to evaluate individuals' physical activity by revealing their energy consumption values. Therefore, it was aimed to make this scale available to Turkish healthcare professionals by conducting the Turkish validity and reliability study.

Individuals forming modern societies along with technological developments are increasingly adopting sedentary lifestyle. This situation increases the risks in terms of morbidity and mortality. For this reason, especially all countries build their health policies on increasing physical activity and make strides to improve it. In order to reach the ideal physical activity level, the physical activity level should be evaluated. However, when the literature is evaluated, it is possible to come across different and many physical activity evaluation methods. This makes it difficult to compare. On the other hand, many researchers prefer to use scales and surveys because of their low costs and ease of use. Although there are many physical activity assessment scales in the literature based on age, gender, disorder or disease, social needs and other features, many of them cannot be used in our society because they are not Turkish. This poses an important obstacle for Turkish researchers to evaluate physical activity.

"The Active-Q: Physical Activity Questionnaire" is a web-based scale developed to investigate the absence of physical activity and activity for individuals over the age of 18. Individuals are asked to answer questions about their activity habits in the past year. By developing the scale, Bonn et al. Tested its validity and reliability comparatively with the 'Double labeled water' method and the accelerometer.

The investigators think that "The Active-Q: Physical Activity Questionnaire" will help physiotherapists and other health professionals in the field and in the field to evaluate individuals' physical activity by revealing their energy consumption values. Therefore, it was aimed to make this scale available to Turkish healthcare professionals by conducting the Turkish validity and reliability study.

Eligibility Criteria:
Inclusion Criteria:

* to be a native Turkish speaker
* to be a volunteer

Exclusion Criteria:

* to make any form of weight alternation diet
* to be pregnant
* to have given birth during last 1 year
* to have any chronic and/or orthopedic disease/problem/syndrome
* to have any traumatic injury or any form of surgery during last 1 year
A Pilot Study Of The Effects Of Microcurrent On Three Sleep Surveys

Participants identified as having primary insomnia will be randomly assigned to groups receiving microcurrent stimulation or sham in a double-blind randomized controlled trial. The microcurrent device used is FDA approved for the treatment of insomnia.

The hypothesis is that the experimental group will have significantly improved scores on three sleep surveys after treatment while the sham group will not.


Eligibility Criteria:
Inclusion Criteria:

* Student, Faculty or Staff
* Age 18 - 40
* Symptoms of primary insomnia

Exclusion Criteria:

* No implanted electric devices
* No local infection, injury or malignancy
* No history of seizure or other neurological disorders
* No current use of prescription or other substances that could effect sleep quality or quantity
* Pregnancy
Immune and Metabolic Effects of Vitamin D Supplementation in Healthy Humans

In this placebo controlled study the investigators aim to investigate the effect of a 3 month vitamin D supplementation on parameters of the immune, endocrine and metabolic system in healthy women and men. Vitamin D. In a pilot study the investigators showed an increase of certain immune cells, which regulate immunotolerance, the investigators therefore try to confirm these results with a placebo group. Furthermore the investigators assess the effect of vitamin D on the glucose metabolism and hormone levels.

This is a randomized double-blind placebo controlled trial, with the aim to investigate the effect of a Vitamin D supplementation on parameters of the immune, endocrine and metabolic system in healthy humans without diabetes and obesity.

The primary aim is to assess the effect of vitamin D supplementation of the number and function of peripheral regulatory T-cells (Tregs). The investigators will measure the Tregs at baseline and monthly for 3 months. Furthermore the investigators assess additional immune cells from the adaptive immunosystem.

Furthermore the investigators will perform a standard mixed meal tolerance test at baseline and 3 months following the supplementation in order to assess the insulin secretion in vivo.

Eligibility Criteria:
Inclusion Criteria:

* Age \>= 10 years
* healthy subjects without chronic disease

Exclusion Criteria:

* Hypercalcemia \>2,65 mmol/L
* pregnancy and lactation period
* acute infections
* chronic disease requiring treatment
Efficacy of Quetiapine for Pediatric Delirium

This study is designed to assess the safety and efficacy of quetiapine as treatment for pediatric delirium.

Many children in the ICU become confused, due to their underlying illness or treatment effects. The medical term for this confusion is delirium. In adults, a medication called quetiapine has been effective in treating delirium. This is considered an "off label" use as the FDA has not approved quetiapine for this indication.

Pediatricians have been using quetiapine to treat delirium in children as well, but there is currently no data proving that it is effective in children. This study is being done to determine if quetiapine is effective for the treatment of ICU delirium in children.

Eligibility Criteria:
Inclusion Criteria:

- Any patient in the PICU aged 1 year to 21 years old who is diagnosed with delirium

Exclusion Criteria:

* Age \<1
* Richmond Agitation Sedation Scale (RASS) score of -4 or -5 (deeply sedated or unarousable).
* current treatment for alcohol withdrawal
* hepatic encephalopathy
* pregnancy
* diagnosis of major depressive disorder or bipolar disorder
* diagnosis of movement disorder
* diagnosis of diabetic ketoacidosis
* baseline QTc \>500 milliseconds
* non-English speaking subjects and/or parent/guardian
Pet Ownership and Glucose Control in Type 1 Diabetes

The investigators' long-term goal is to discover novel, inexpensive and feasible strategies to improve the management and well-being of youth with T1DM. The specific objective of this proposal is to quantify the impact of responsible pet ownership on the glycemic control and health related quality of life in youth with T1DM.

Type 1 diabetes mellitus (T1DM) affects 151,000 children and adolescents in the United States. Youth with T1DM are at a high risk for multiple psychosocial co-morbidities including poor health related quality of life (HRQoL) which is linked to medication non-compliance and increased risk for diabetes-related complications. Any reduction in the psychosocial adjustment difficulties related to T1DM could improve the medical outcome of children with T1DM.

Current standards for diabetes management reflect the need to maintain glucose control within a normal range. However, numerous reports indicate that normalization of blood glucose levels is seldom attainable in children and adolescents. Family cohesion, positive coping strategies, younger age of onset, social support and adequate self-regulatory behavior are found to favorably influence glycemic control. One may conclude that the presence of a companion animal, capable of enhancing the positive factors named above, would augment the array of tools available for the successful management of chronic illnesses such as T1DM.

There is a lack of studies assessing the impact of pet ownership on the health and well-being of adolescents. The process of caring for, loving and being loved by a companion animal could offer direct and/or indirect benefits to the HRQoL in children with T1DM. To the investigators' knowledge, there are no studies examining the impact of pet ownership on glycemic control and HRQoL in youth with T1DM.

Eligibility Criteria:
Inclusion Criteria:

* English-speaking patients
* 10 to 18 years
* diagnosed with type 1 diabetes for at least 12 months
* poor diabetes control as defined by having a hemoglobin A1c value \> 8%

Exclusion Criteria:

* type 2 diabetes
* developmental delay
* current participation in another study that may impact glycemic control
Remote Monitoring of AF Recurrence Using mHealth Technology

Atrial fibrillation (AF) is the most common arrhythmia worldwide. It carries a significant health burden, conferring on sufferers a reduction in quality of life, risk of significant morbidities such as stroke and heart failure, and significant mortality. At present, diagnosis of AF involves referral for conventional 12 lead electrocardiogram (ECG) recording, ambulatory ECG for fixed time period recording, or insertion of implantable loop recorders (ILR). These investigations are limited both by recording only at specific time points and failing to explore the interaction between heart rate and day-to-day physical activity. In recent years, the use of mobile health (mHealth) devices has emerged as a direct-to-consumer option for monitoring parameters such as heart rate and activity levels. From a clinical perspective they potentially offer a less invasive and cost-effective investigative approach, with remote monitoring solution to identify and possibly predict AF. In this study, the investigators propose to recruit participants who have undergone an ablative procedure as part of a randomised clinical trial (LoTO in CASA LSPAF: NCT04280042) and monitor for recurrence of AF using mHealth technology by correlating with ILR data.


Eligibility Criteria:
Inclusion Criteria:

* Participants in LoTO in CASA LSPAF with implanted loop recorders (ILR)

Exclusion Criteria:

* Participants in LoTO in CASA LSPAF who had their ILR explanted
The Effect of Platelet Rich Plasma for Carpal Tunnel Syndrome

The platelet rich plasma (PRP) is a new and potential treatment for patients with kinds of musculoskeletal disorders. Although few studies have showed beneficial effect of PRP for regeneration of peripheral neuropathy in animal study, the associated study in human is rare.

The platelet rich plasma (PRP) is a new and potential treatment for patients with kinds of musculoskeletal disorders. Although few studies have showed beneficial effect of PRP for regeneration of peripheral neuropathy in animal study, the associated study in human is rare. We performe a prospective study to investigate the effect of PRP in patients with carpal tunnel syndrome.

Patients with carpal tunnel syndrome (CTS) were randomized into intervention and control group. Participants in intervention group received sono-guided injection with 3cc PRP and control group received night splint. The evaluation was performed pretreatment as well as on the 1st, 4th, 8th, 12th, 16th and 24 week after the treatment.

Eligibility Criteria:
Inclusion Criteria:

1. Age between 20-80 year-old.
2. Typical symptoms and signs of CTS, such as positive Tinel's sign or Phalen's test, numbness/tingling in at least two of the first, second, or third digits, and in whom the diagnosis was confirmed using an electrophysiological study.

Exclusion Criteria:

1. Cancer
2. Coagulopathy
3. Pregnancy
4. Inflammation status
5. Patients who had conditions mimicking CTS, such as cervical radiculopathy, polyneuropathy, brachial plexopathy, thoracic outlet syndrome or who had previously undergone wrist surgery or steroid injection for CTS.
Value of Oesophagal Videocapsul and Oeso-gastro-duodenal Fiber Endoscopy for the Screening of Oesophagal Varix for Cirrhotic Patients

The purpose of this study is to determine the equivalence or not of diagnosis ability of oesophagal videocapsul versus oeso-gastro-duodenal fiber endoscopy in the screening of oesophagal varix.


Eligibility Criteria:
Inclusion Criteria:

* 18\< age\< 80
* Diagnosis of a cirrhosis
* suspicion of portal hypertension without known diagnosis of a cirrhosis
* Able to give an inform consent

Exclusion Criteria:

Related to pouplation

* case history of cancer or oesophagal surgery
* case history of an ORL cancer
* case history of evolutive cancer

Related to pathology

* Previous fiberoptic endoscopy with OV diagnosis
* Less than 6 month since last fiberoptic endoscopy

Related to tested device

* clinical suspicion of oesophagal stenosis for a patient presenting a dysphagia to solids
* Zenker diverticuls attested
* clinical suspicion of small intestinal stenosis
* patient with pace-maker or any other inter device
* pregnant women
* deglutition troubles withfalse passage and/or conscience troubles