cyrilzakka/clinical-trials huggingface dataset:
International Registry for Patients With Castleman Disease

The purpose of this study is to collect clinical, laboratory, and patient survey data from patients with Castleman disease to improve understanding, diagnosis, and treatment of the disease.

This project is supported by the Castleman Disease Collaborative Network.

Visit the CDCN website at http://www.cdcn.org/accelerate to sign up for the ACCELERATE registry!

The ACCELERATE patient registry will give patients and families the opportunity to contribute their medical data to improve understanding of Castleman Disease. The patient registry will obtain real-world demographic, clinical, laboratory, and patient reported outcomes, and treatment data from 1000 patients worldwide with Castleman Disease.

This registry will help to provide important data for future Castleman Disease research studies. The patient registry helps centralize information on this rare disease, and provides researchers a way to obtain data on Castleman Disease patients. The major objectives for the registry include:

1. Improve our understanding of the natural history (signs, symptoms, laboratory values, survival data, outcome predictors), pathogenesis, and treatment of Castleman disease by collecting a standardized set of demographic and longitudinal data from CD patients,
2. Build capacity for collaboration between patients, providers, researchers, and industry by collecting clinical data and tracking the location of all available tissue samples for future studies ("virtual biorepository"), and
3. Assemble \&#34;real-world\&#34; data related to burden of disease, treatments used, tolerability, and safety data.

Individuals affected by Castleman Disease and families of deceased patients are invited to join the registry.

Patients located anywhere in the United States of America (USA), Canada, or rest of world will be able to enroll themselves directly into the registry. Participants will enroll online and be asked to provide their electronic medical records to University of Pennsylvania researchers for data extraction. All patients will also be asked to complete questionnaires every three months about their symptoms, treatments, and experiences with Castleman Disease. Complete participant information will be stored in a secure database.

Researchers who are interested in studying Castleman Disease can also request access to registry datasets.

Eligibility Criteria:
Inclusion Criteria:

* Person of any age
* Have a reference pathology report suggesting "Castleman disease" not limited to cutaneous involvement only that can be uploaded
* Be able to provide electronic informed consent, as per local regulations
* Deceased patients may also be enrolled when a reference pathology report suggesting "Castleman disease" can be supplied or when the ART is able to locate and upload such a pathology report.

Exclusion Criteria:

* Because this registry is designed to provide as wide a picture of routine clinical practice as possible, inclusion criteria are set deliberately wide and there are no exclusion criteria.
Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery

The investigators are testing the hypothesis that administering 2L of body temperature warmed lactated ringer's intravenously prior to surgery can optimize the postoperative and recovery of patients undergoing total hip and total knee arthroplasty.

Hip and knee arthroplasty are safe and reliable surgeries for the majority of patients, but a small percentage experience major complications such as myocardial infarction, deep vein thrombosis (DVT), and pulmonary embolism (PE). As these complications are related to local tissue hypoxemia and patient immobility, interventions that can improve the ability of the heart to deliver blood to the tissue and help patients mobilize earlier in their postoperative course may decrease these complications. Based on recent evidence, it has been shown that many patients are dehydrated before surgery, which can make them feel nauseous, tired, and increase their perception of pain making them less likely to mobilize. This predisposes them to DVTs, pulmonary embolism, nausea and vomiting. Peri-operative dehydration can also decrease the ability of the lungs to oxygenate the blood properly and can place additional stress on the heart, which can increase the risk of heart attacks. The specific aim is to determine if patients' peri-operative hemodynamics can be improved with preoperative administration of 2 L of lactated ringers, and consequently reduce postoperative complications and improve recovery in arthroplasty patients.

Eligibility Criteria:
Inclusion Criteria:

* All patients \>= 18 years of age, undergoing a total primary knee or hip arthroplasty

Exclusion Criteria:

* Patients weighing less than 80 kg.
* Patients undergoing irrigation and debridement, explantation, or revision will not be eligible.
* history of kidney disease, congestive heart failure, pulmonary edema, cirrhosis of the liver, or history of systemic fluid overloard will be excluded from the study.
* No one will be excluded based on gender, ethnicity or race.
Comparison of the Swallowing Functions in Sarcopenia and Dynapenia

The purpose of the study to investigate the comparison of the swallowing functions of the sarcopenia and dynapenia in older patients

Sarcopenia is a geriatric syndrome; from skeletal muscle, and in its usefulness. Dynapenia is a picture of sarcopenia without measurable muscle mass. It has been shown that dysphagia complaints are more common in patients with sarcopenia than in the normal population, but a comparison with patients with dynapenia has not been made to the best of our knowledge. According to the algorithm of The International Society of Physical and Rehabilitation Medicine (ISPRM), experts in the special interest group on sarcopenia, in the routine examination of patients aged 60-90 years who applied to the Physical Medicine and Rehabilitation outpatient clinic with complaints of decreased muscle function, weakness, and slow movement, or "sarcopenia" or Patients with "dynapenia" and patients without Sarcopenia disease who volunteered to participate in the study will be included in the order of application to the outpatient clinic.

Eligibility Criteria:
Inclusion Criteria:

* Age between 60-90 years
* Sarcopenia and dynapenia patients in study groups
* Non- sarcopenia and non-dynapenia patients in control groups
* Patients who were accept to consent form

Exclusion Criteria:

* Severe sarcopenia patients
* Cognitive limitations
* Out of age 60-90 years old
* Patients who were not accept to consent form
Sleep Quality and Related Factors in Hemodialysis Patients

Sleep quality is an important predictor of healthy status,quality of life and life span. Sleeping problems affect 50%\~80% in hemodialysis patients. Sleep quality and related factors research in hemodialysis patients has been discussed and studied globally. Previous studies show insomnia, excessive daytime sleepiness(EDS), sleep apnea syndrome(SAS), restless legs syndrome(RLS) are major causes of poor sleep quality . There is few data to show the influential factors related to sleep quality in Taiwanese hemodialysis patients.

This study will be a cross-sectional design with purposive sample from 2 different dialysis medical centers in Taipei. Two hundred hemodialysis patients meeting inclusion criteria will be recruited.

Eligibility Criteria:
Inclusion Criteria:

* Hemodialysis patient whose age ≧ 20 years old and conscious clear.
* ICD9：585.6
* Every week receives two or three convention hemodialysis treatment above three months.
* May communication with Mandarin or Taiwanese language.
* Patient or caregiver is willing to participate study and sign the inform consent.

Exclusion Criteria:

* Hospitalized hemodialysis patient in recently one month.
* Hemodialysis patient had conscious disturbance, blind or dementia.
* Hemodialysis Patient refuse to interview or fill out questionnaires.
Ramelteon in the Prevention of Post-operative Delirium

This trial focuses on a Phase II randomized masked clinical trial testing the effectiveness and safety of peri-operative administration of ramelteon, a melatonin agonist in the prevention of postoperative delirium.

This trial will randomize older aged patients undergoing general or regional anesthesia for orthopedic surgical procedures to three perioperative doses of a melatonin agonist, ramelteon, and placebo in a masked double blind fashion. The primary outcomes are 1) the incidence of post-operative delirium in the recovery period in the Postoperative Anesthesia Care Unit and on post-operative days 1 and 2 following surgery, and 2) the safety of ramelteon as documented by the presence of adverse events in the follow-up period.

Eligibility Criteria:
* Planned orthopedic surgery under general or regional anesthesia and post-operative inpatient stay
* 65 years of age or older
* Mini-mental Status Exam (MMSE) score of 15 or greater prior to surgery;
* Ability to understand, speak, read and write English.

Exclusion Criteria:

* Delirium diagnosis on the Confusion Assessment Method instrument at baseline
* Is unable to give informed consent due to cognitive impairment and a suitable legally authorized representative (LAR) cannot be identified
* Declines participation
* Current medications that include:

  1. ramelteon
  2. melatonin
  3. fluvoxamine
  4. rifampin
  5. ketoconazole
  6. fluconazole
* History of ramelteon or riboflavin intolerance
* Heavy daily alcohol intake by medical record or history
* Current moderate to severe liver failure (as defined by Charlson criteria
* Evidence of Systemic Inflammatory Response Syndrome (SIRS) as measured by \> 2 criteria8)
* Presence of a condition that in the opinion of the PI compromises patient safety or data quality if enrolled in the study.
Influence Factors and Cognitive Characteristics in Unipolar and Bipolar Depression:Based on the THINC-it Tool

Cognitive impairment is the core symptom of unipolar and bipolar depression, which seriously affects the prognosis of the disease and the rehabilitation of social function. There is no unified conclusion in the field and severity of cognitive impairment, and the cause of cognitive impairment is unknown, which may be related to many factors. In this study,the THINC-it tool was used to study the characteristics of cognitive impairment in unipolar and bipolar depression by longitudinal follow-up, which provides a theoretical basis for the differential diagnosis of unipolar and bipolar depression. Early identification and intervention of risk factors can improve the prognosis of the disease.

there is some cognitive impairment in patients with unipolar and bipolar depression. There is no unified conclusion in the field and severity of cognitive impairment, and the cause of cognitive impairment is unknown, which may be related to many factors. The THINC-it is a simple, fast and free cognitive assessment tool for cognitive impairment screening of unipolar and bipolar depression.

This study includes three steps.

1. baseline: demographic data, theTHINC-it tool , clinical scales（HAMD-17,HAMA、YMRS、PSQI） evaluation and Laboratory examination（blood glucose, blood lipids, BMI）
2. follow-up (4 week): Clinical scales and THINC-it tool were evaluated in unipolar and bipolar depression.
3. follow-up (12 weeks): all patients with bipolar depression were evaluated by clinical scales, THINC-it test.

Eligibility Criteria:
Inclusion Criteria:

Case group:

1、Participants in psychiatric outpatients and inpatients are able and willing to provide informed consent.

2. The participants were male or female aged between 18 and 60, with junior high school education or above.

3. According to ICD-10 criteria, participants were diagnosed with Unipolar and bipolar depressive disorder.

4. The total score of Young's Mania scale ((YMRS)) of the participants was less than 5 and HAMD-17 was greater than17.

5. Subjects received stable mood stabilizers at least two weeks before the study visit, such as SSRIs antidepressants.

6. The combination or use of supportive psychotherapy is allowed.

Control group:

1.it did not meet any of the diagnostic criteria in ICD-10 in the past or at present.

2.18-60 years old, junior high school education or above. 3.Have sufficient audio-visual skills to complete the necessary examinations of the study.

4.Willing to participate in this study, and the informed consent form was signed by the subjects.

Exclusion Criteria:

1. Current alcohol and / or substance use disorders.
2. Any drugs that may affect cognitive function, such as psychotropic stimulants, corticosteroids, and receptor blockers.
3. Benzodiazepines were used within 12 hours and alcohol consumption within 8 hours before using the THINC-it tool.
4. The patients have some serious physical conditions.
5. The patients received electroconvulsive therapy ((ECT)) in the past 6 months.
6. They are serious negative suicidal concepts and behaviors.
Pregabalin for Post-craniotomy Pain Control

Background:

Proper pain relief is a major concern of patients worldwide. Preoperatively, one of the most common questions asked by patients pertains to the amount of pain they will experience after surgery how long it will last and how good will it be controlled. Pain concerns the surgical team as well, because of its correlation with clinical outcomes and patients' satisfaction rate. Studies have shown that negative clinical outcome with regard to pain control includes decreases in vital capacity and alveolar ventilation, pneumonia, tachycardia, hypertension, myocardial ischemia, transition into chronic pain, poor wound healing, and psychological sequelae .

Pain has been found to be one of the three most common medical causes of delayed/aborted discharge after ambulatory surgery, the other two being drowsiness and postoperative nausea/vomiting. Despite progress that has been made with regard to postoperative pain control, and the development of new standards for pain control, many patients continue to experience intense pain after surgery .

Recent advances in the understanding of the particularities of central sensitization indicate that it plays an important role in post surgical and post traumatic pain and therefore should be avoided

Hypothesis:

No studies considered the comparison of pre-emptive and post-incisional or post-surgery PGL administration. The investigators hypothesize that the administration of PGL preemptively would diminish pain sensation, and therefore the need for pain administration in neurosurgical patients, better than postoperatively. In addition, preoperative administration could reduce the level of anxiety in these patients.

It should be stressed that this study will used a placebo controlled group and at availuating placebo related psychological effective treatment versus a central efficacy of Lyrica

Objectives:

To assess the beneficial preemptive and preventive effects of PGL on the immediate and late (1- and 3 months) postoperative analgesia requirements and pain scores in neurosurgical patients.

Eligibility Criteria:
Inclusion Criteria:

* ASA (American Society of Anesthesiologists) physical status I-III
* patients who will undergo intracranial surgery under general anesthesia only
* Patients undergoing awake-technique procedures will also be enrolled.

Exclusion Criteria:

* allergy to opioids, midazolam, PGL, or non-steroidal anti-inflammatory drugs (NSAIDs), dipyrone
* history of chronic pain or psychiatric disorders and the use of centrally acting antidepressant and antipsychotic drugs. Patients longtime users of sedatives, or antiepileptics
* soldiers and pregnant women
* Emergency cases, DBS procedures and patients unable to comprehend and sign the consent form
Which is More Effective in Management of Bruxism: Botox or Occlusal Splints

The aim of this study is to compare the efficacy of Botulinum toxin (Botox) and traditional occlusal splints for the management of bruxism in edentulous patients rehabilitated with MIOD

42 edentulous patients having implant retained mandibular overdenture suffering from bruxism with clinical manifestation, will be randomly divided into three groups, group 1 control group (traditional approach of removing denture at night) ,group 2 will be managed by occlusal splints whereas group 3 will be managed with botulinum toxin injection (Botox). New maxillary dentures and mandibular over dentures will be constructed for both groups. Muscle activity will be measured at time of denture insertion (T0), 3(T3) 6(T6), 9(T9) and 12(T12) month of treatment. Patients satisfaction will be evaluated at the time of denture insertion (T0), 6(T6), and 12(T12) month of treatment using TMD/ NS numeric scales 10 cm questionnaire which include: headache, face pain, face tension, limitation of mouth opening and complaints during mastication.

Eligibility Criteria:
Inclusion Criteria:

* patients diagnosed with bruxism
* patients had mandibular implant retained overdentures within the previous 3 years
* cooperative patients
* physically and psychologically able patients to tolerate the procedure

Exclusion Criteria:

* patients taking muscle relaxants
* patients without neuromuscular control
* poor oral hygiene
LAP-BAND AP Early Experience Trial (APEX)

The purpose of this study is to evaluate the LAP-BAND AP System in severely obese patients.

The primary objective of this study was to collect additional information about the safety and effectiveness of the LAP-BAND AP System in a real-life clinical setting. Effectiveness was assessed through the collection of weight loss data, as well as other secondary effectiveness measurements. Safety was assessed by the incidence and severity of adverse events (AEs) related to treatment.

Eligibility Criteria:
Inclusion Criteria:

* Patient is scheduled to receive the LAP-BAND AP System
* Willingness to follow protocol requirements, including: the Informed Consent Form (ICF), Health Insurance Portability and Accountability Act (HIPAA) forms, follow-up schedule, completion of patient questionnaires.

Exclusion Criteria:

* Per the LAP-BAND AP System Directions For Use (DFU)
Platelet Kinetics After Platelet Transfusion for the Placement of a Central Venous Catheter

PLATCAT study's purpose is to evaluate platelet kinetics after platelet transfusion


Eligibility Criteria:
Inclusion Criteria:

* Admission en haematology unit
* Need for a central venous catheter
* Thrombopenia \< 50 G/L

Exclusion Criteria:

* Patient protected by law
* Pregnant or breastfeeding women
* Peripheral thrombopenia
* Patient admitted in Intensive Care Unit
Effects of a Goal-directed Hemodynamic Therapy Driven by ECOM on Morbidity and Mortality After Cardiac Surgery?

Goal-directed hemodynamic and fluid optimizations are shown to be a key factor of the medical care during anesthesia.According to medical literature, goal-directed fluid and hemodynamic optimizations are more efficient when based on the dynamic parameters than when based on the statics ones, and the major dynamic criteria is the cardiac output. Unfortunately, transpulmonary thermodilution, the device considered as "The gold standard" to evaluate cardiac output is associated with many complications.Furthermore, devices commercialized in the past decade were not able to replace the transpulmonary thermodilution.

As all monitoring devices aren't reliable enough to be widely used in practice they are left aside in benefits of the clinical evaluation. Even though, hemodynamic optimization based on the analysis of several clinical parameters seems to guarantee good cares thanks to a favorable benefits/risks balance, it could be improved by new plug and play mini-invasive systems.

In the investigators opinion, the ECOM system seems able to provide a monitoring tool which responds to all the expectations of a modern hemodynamic monitoring device. It uses a well known technique, the bioimpedance. The investigators suppose this device should be more efficient than the one that has been used before. Indeed, as the system is build on the endotracheal tube, it comes closer to the aorta, where all the measures are made, and the recorded signal should be less affected by the passage through the surrounding tissues.

This randomized and controlled trial will study Patients scheduled for elective coronary surgery with cardiopulmonary bypass.

The purpose of this trial is to evaluate the benefits of an intraoperative goal-directed hemodynamic therapy based on the ECOM cardiac output measure on mortality and major postoperative cardiac morbidity after coronary surgery, when compared with a standard management strategy.

Patients will be allocated into control and ECOM groups, of 50 peoples each. The standard management strategy, applied to the control group, will be set and led by the attending anesthetist, based on the analysis of further clinical parameters. The ECOM Group will face the hemodynamic optimization strategy led by the ECOM evaluation of cardiac output and stroke volume variation.

The main hypothesis is that the hemodynamic strategy led by the ECOM cardiac output measure will reduce mortality and morbidity after cardiac surgery.


Eligibility Criteria:
Inclusion Criteria:

* Any man or woman
* Over 18 year-old
* After obtaining written informed consent
* Scheduled for elective coronary surgery with CPB

Exclusion Criteria:

* Emergency surgery (\< 24h)
* Combined cardiac surgery
* Patients \< 18 years-old and/or unable to give informed consent
* Patients who refuse to give informed consent
* Pregnancy
* PVC allergy
Diagnostic and Management of Hand Infection.

Primary or secondary (post-traumatic infections, notably related to bites, wounds, etc.) infections of the hand are very common situations, even if the epidemiology is poorly understood. For example, hand bite injuries represent 1.2 million referrals to the healthcare system per year in the United States. Their nosological framework extends from simple infections of the skin and soft tissues such as whitlows, to potentially severe deep damage such as arthritis and osteitis, or phlegmons of the tendon sheaths. The diagnostic approach is not consensual, and the contribution of additional biological parameters (inflammatory syndrome) and morphological investigations (x-rays, ultrasound, CT-scan or MRI) is not codified. Microbiology seems dominated by Staphylococcus aureus, but few studies have precisely described the microbial etiology. Consequently, probabilistic antibiotic therapy and the need to take bacteriological samples for secondary adaptation are not standardized. Likewise, surgical strategies (abstention, systematic washing or depending on evolution) remain operator dependent. We consequently aim to described diagnostic, management and related outcomes or hand infections in a specialized tertiary care center.


Eligibility Criteria:
Inclusion Criteria:

* all patient ≥ 18
* yo followed-up for a hand infection in our tertiary care center
* from 01/01/2014 to 31/12/2023, including
* whitlows
* tendinous infections
* septic arthritis

Exclusion Criteria:

* osteomyelitis