cyrilzakka/clinical-trials huggingface dataset:
Esthetic Outcomes Following Immediate Implant Combine With Soft Tissue Augmentation

The purpose of this study is to evaluate the esthetic outcomes following immediate implant combined with the autogenous tissue graft or acellular dermal matrix compared to immediate implant alone.


Eligibility Criteria:
Inclusion Criteria:

* patients who are in need of a tooth extraction at the maxillary premolar, canine and incisor region, and subsequent single implant placement.
* The reasons for extraction will include poor endodontic prognosis and/or unrestorable teeth (extensive caries, traumatic fractures, fractures of endodontically treated teeth, root perforation, root resorption with or without radiographic periapical lesion up to 3 mm in diameter). patients who are systemically healthy or with controlled common systemic conditions (controlled hypertension, controlled diabetes HbA1c up to 7 %).
* adjacent teeth have to be present and the eligible tooth has esthetically acceptable buccal gingival margin position prior to surgery, compared to neighboring teeth and contralateral tooth, and adequate width of buccal keratinized gingiva(≥3mm).
* level of radiographic bone level has the distance from CEJ to interproximal crest up to 4 mm.
* Location of buccal alveolar crest has to be generally within 4 mm from the free gingival margin, verified after the extraction, before randomization; and fenestration, if present, up to 3mm in diameter at the apical part of the root and affecting less than 30% of the buccal socket wall.

Exclusion Criteria:

* currently smoke exceeding 10 cigarettes/ day
* severe parafunctional habits, malocclusion or intent of orthodontic therapy in the future and are pregnant.
* teeth in the surgical site will be excluded if there is advanced periodontal disease or periapical lesion causing significant bony defects that are beyond the criteria mentioned at Section 3.3.
* allergy to antibiotics contained in the ADM (Gentimicin, Cefoxitin, Lincomcin, polymixin B and Vancomycin) will not be included in the immediate implant combined with ADM group.
Assessment of Lifestyle, Blood Pressure, Cholesterol and Glycated Hemoglobin in a Specific Population

The project Shall we get to know your health better? Lifestyle assessment, blood pressure and cholesterol in the population of Libbs Farmacêutica employeesLTDA.; consists of a study that will bring knowledge and enable quantificationof risk factors related to cardiovascular diseases in this population above mentioned.

The social relevance of this study is related to the knowledge and quantification of eating habits and lifestyles related to cardiovascular diseases in the population of employees, also referred to in this document as "employees", from Libbs Farmacêutica Ltda. Based on an observation and statistical analysis of the data obtained in this study, internal policies will be promoted that aim to improve eating habits, physical activity and decrease smoking.

Eligibility Criteria:
Inclusion Criteria:

* Being an employee Libbs Farmacêutica Ltda;

Exclusion Criteria:

* not applicable
The Effect of Virtual Reality on Pain and Memory.

The effect of Virtual Reality on pain and memory.

The primary outcome measure was the participants' accuracy of remembering the pattern of a total of five pain stimuli per set. Using the Quantitative Sensory Testing "method of limits", each participant selected a temperature they found "painful but tolerable" that they were willing to receive several more times, later in the study. They then received a sequence of five brief stimuli to their wrist, with a brief inter-stimulus interval between each stimulus.

Eligibility Criteria:
Inclusion Criteria:

* must be English speaking (but English does not necessarily need to be native/first language).
* must be willing to follow our UW approved instructions,

Exclusion Criteria:

* Not capable of indicating pain intensity
* Not capable of filling out study measures
* Non-English-speaking
* Extreme susceptibility to motion sickness
* Seizure history
* Unusual sensitivity or lack of sensitivity to pain
* Sensitive skin
* sensitive feet
* migraines
* cold symptoms
* Diabetes
* Or if you are under 18 years old
Lifestyle Online Re-Intervention On Blood Pressure, BMI, And Physical Activity On Obese Hypertensive Patients

This research will constitute a 3 years follow-up which includes a re-assessment and re-intervention of obese or overweight adults with hypertension, recruited from a hypertension unit of a public hospital, that already participated in a similar program 3 years ago. At the same time, the aim of the study is to analyze the effects of the current program, which will take 3 months and promotes lifestyle changes focusing on healthy eating and increased physical activity in their 9 modules, comparing the results obtained in 2018. These patients will be allocated into one experimental group. Assessment will include: Blood Pressure, Body Mass Index, Physical Activity levels, and adherence to the Mediterranean diet.

Hypertension incidence and overweight or obesity related, constitute a worrying public health problem nowadays. In this sense, healthy eating and regular physical activity have demonstrated a relevant role maintaining health while ageing. Information and Communication Technologies (ICTs) have been shown as a useful way to promote health, improving motivation and overcoming difficulties to maintain a healthy lifestyle. ICTs also reach a wider audience at a lower cost, due to their good cost-benefit relationship and the possibility of increasing the efficiency of interventions.

This research will constitute a 3 years follow-up which includes a re-assessment and re-intervention of obese or overweight adults with hypertension, recruited from a hypertension unit of a public hospital, that already participated in a similar program 3 years ago. At the same time, the aim of the study is to analyze the effects of the current program, which will take 3 months and promotes lifestyle changes focusing on healthy eating and increased physical activity in their 9 modules, comparing the results obtained in 2018. These patients will be allocated into one experimental group. Assessment will include: Blood Pressure, Body Mass Index, Physical Activity levels, and adherence to the Mediterranean diet.

Eligibility Criteria:
Inclusion Criteria:

* Hypertension
* Overweight or obesity (25 ≤ BMI ≤ 35 kg/m2)
* Aged between 18-65 years
* Have participated in the same program 3 years ago

Exclusion Criteria:

* Not having access to the Internet or lack of information about it.
* Treatment with more than 3 antihypertensive drugs.
* Meet the criteria of the DSM-IV-TR of a Food Disorder.
* Presenting some type of severe psychiatric disorder.
* Disability that prevents or hinders physical exercise.
* Receiving some treatment for weight loss.
Can Amino Acid Supplementation Augment the Anabolic Response in Tendon After Exercise

The goal of this study is to determine if an oral provision of amino acids will enhance exercise-induced increases in markers of Achilles tendon collagen production.

Tendon pain is a common complaint in older adults. The mechanisms contributing to the large number of tendon problems in older adults are not known. It has been shown that tendon cross-sectional area (CSA) is reduced with aging concurrent with a significant loss of tendon collagen. Exercise is used to reverse the loss of muscle mass with aging but surprisingly exercise interventions designed to reduce tendon problems in older people are relatively unexplored. In young adults, exercise stimulates tendon collagen synthesis and enhances the production of growth factors, which stimulate tendon collagen production. It is presumed that exercise-induced increase in collagen synthesis contributes to the increase in tendon stiffness and CSA noted in young adults after chronic resistance exercise (RE). In contrast, our preliminary work indicates that RE is not effective at reducing the effects of aging on tendon. The investigators have demonstrated that 12-weeks of RE does not lead to increases in tendon CSA or stiffness, even when skeletal muscle mass and strength are greatly enhanced. To prevent tendon injury, greater tendon CSA and stiffness aid in withstanding the force generated by trained skeletal muscle. Greater CSA and stiffness also optimize force transfer through tendon to maximize musculoskeletal function. Our findings indicate that RE is not an optimal intervention for reversing age-related changes in tendon properties. Novel interventions are clearly needed that will enhance collagen synthesis leading to an increase in tendon stiffness and CSA while also improving skeletal muscle mass and strength in older individuals. This study will evaluate the effectiveness of various methods for stimulating tendon collagen synthesis during a bout of acute exercise. Specifically, the investigators propose two approaches to this problem.

1. An acute bout of cycling exercise will enhance the release of growth factors leading to a larger increase in tendon collagen synthesis.
2. A bolus of amino acids given orally will increase the release of key stimulators of tendon collagen synthesis leading to enhanced collagen synthesis after acute exercise.

Eligibility Criteria:
Inclusion Criteria:

* 21-35 years or 60-80 years old

Exclusion Criteria:

* diabetes
* BMI\>35
* acute illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, metabolic disorders, arthritis, or a history of neuromuscular problems.
* chronic pain medication users
* alcoholism
* competitive athletes
* pregnant women will be excluded
* Individuals with specific allergies to amino acids
Nitroglycerin as Spasmolytic Regimen for RAS Prevention in Radial Center

The investigators will investigate whether administration of Nitroglycerin (NTG) as spasmolytic regimen reduces the incidence of moderate to severe radial artery spasm (RAS) in patients undergoing transradial catheterization in radial center.

Patients will be randomized to receive either 200 microgram NTG or placebo (saline) at the beginning of the procedure soon after radial sheath placement. The operators will be blinded to both assignment. The primary outcome is the incidence of moderate to severe RAS evaluated by the operators during the radial procedure.

Both NTG and placebo will be administered using an identical syringe to keep the operators blinded to the treatment allocation. Radial angiogram is mandatory to measure the diameter of both radial and ulnar arteries. Doppler ultrasound of the radial artery will be examined at the day after the procedure.

Eligibility Criteria:
Inclusion Criteria:

* All patients undergoing transradial catheterisation using proximal radial artery puncture technique

Exclusion Criteria:

* Blood pressure \<100 mmHg
* Refuse to participate
Blood Flow Restriction Training for The Shoulder

The aim of this study is to determine if BFR-LIX promotes greater increases in shoulder lean mass, rotator cuff strength, endurance, and acute increases in shoulder muscle activation compared to LIX alone.

Healthy Volunteers: Thirty-two healthy adults were randomized into two groups (BFRm=13,f=3, NoBFRm=10,f=6) that performed 8wks of shoulder LIX \[2/wk, 4 sets (30/15/15/fatigue), 20%max\] using common rotator cuff exercises \[cable external rotation (ER), cable internal rotation (IR), dumbbell scaption (SCAP), and side-lying dumbbell ER (SLER)\]. The BFR group also trained with an automated tourniquet placed at the proximal arm (50%-occlusion). Regional lean mass (dual-energy-xray-absorptiometry), isometric strength, and muscular endurance (repetitions-to-fatigue, RTF, 20%max, with and without 50%-occlusion) was measured before and after training. Electromyographic amplitude (EMGa) was also recorded from target shoulder muscles during endurance testing. A mixed-model ANCOVA (covaried on baseline measures) was used to detect within and between-group differences in primary outcome measures (α=0.05).

Pitchers: Twenty-eight collegiate baseball pitchers were randomized into 2 groups (BFRN=15, NOBFRN=13) that, in conjunction with offseason training, performed 8wks of shoulder LIX \[Throwing arm only; 2/wk, 4 sets (30/15/15/fatigue), 20%isometric max\] using 4 exercises \[cable external and internal rotation (ER/IR), dumbbell scaption, and side-lying dumbbell ER\]. The BFR group also trained with an automated tourniquet on the proximal arm (50%-occlusion). Regional lean mass (dual-energy x-ray absorptiometry), rotator cuff strength (dynamometry: IR0\&90, ° ER0\&90, ° Scaption, Flexion), and fastball biomechanics were assessed pre- and post-training. Achievable workload (sets × reps × resistance) was also recorded. An ANCOVA (covaried on baseline measures) repeated on training timepoint was used to detect within-group and between-group differences in outcome measures (α=0.05). For significant pairwise comparisons, effect size (ES) was calculated using a Cohen's d statistic and interpreted as: 0-0.1, negligible(N); 0.1-0.3, small(S); 0.3-0.5, moderate(M); 0.5-0.7, large(L); \>0.7, very large(VL).

Eligibility Criteria:
Inclusion Criteria:

* Healthy, untrained volunteers

Exclusion Criteria:

1. Previous history of shoulder injury occurring in the laterality of choice
2. Current painful dysfunction resulting in exercise limitation
3. Any health-related exercise limitation as ordered by physician
4. Vascular compromise or previous vascular surgery
5. Ages outside of 18-65
6. Inability to access clinic and equipment
7. Currently involved in structured strength training regimen of the upper extremity
Preoperative Biliary Drainage in Patients With Operable Malignant Periampulary Tumors

The impact of preoperative biliary drainage (PBD) on morbidity and mortality associated with Pancreaticoduodenectomy (PD) in patients with peri-ampulary tumors is still controversial. The objective of this study is to evaluate the impact of PBD on surgical and oncologic outcomes after PD in jaundiced patients with operable peri-ampulary tumors.

150 consecutive jaundiced patients with suspected operable peri-ampullary tumors were randomized via concealed envelopes into 2 groups (each included 75 patients), group I managed by direct surgery while group II managed by PBD followed by surgery. Both groups were compared regarding perioperative mortality, morbidities, tumor recurrence and 2 years survival rates.

Eligibility Criteria:
Inclusion Criteria:

* Serum bilirubin level above 4 mg/dl
* suspected peri-ampullary tumor at computed tomography (CT)
* No evidence of distant metastasis or locally advanced tumor

Exclusion Criteria:

* Patients with evidence of distant metastasis or locally advanced tumor
* Prior neoadjuvant chemotherapy or Radiotherapy
* Prior biliary surgery
* Patients with contraindication for major surgery
Sedation of Mechanically Ventilated Critically Ill Patients: Midazolam Versus Dexmedetomidine

The aim of this prospective randomized study is to compare the safety and efficacy of two strategies for sedation of critically ill patients submitted to mechanical ventilation: continuous intravenous infusion of dexmedetomidine versus intravenous bolus of midazolam. The two groups will be compared as to the incidence of of delirium, evaluated with the Confusion Assessment Method for ICU (CAM-ICU) and the percentage of time within the target sedation using the Richmond Agitation-Sedation Scale (RAAS).Eligible patients will be 18 years or older intubated and mechanically ventilated for less than 48 hours prior to start of study drug and anticipated ventilation duration of at least 48 hours. Calculated sample size is 146 patients (73 patients in each group)


Eligibility Criteria:
Inclusion Criteria:

* Adult mechanically ventilated, critically ill patients

Exclusion Criteria:

* pregnancy or lactation, severe liver disease, hearth rate less than 50, hypotension despite volemic repletion and vasoactive drug
Vitamin D Replacement in Nonalcoholic Fatty Liver Disease

Vitamin D deficiency is very common in patients with fatty liver disease as evidenced by our observations in the Metabolic Liver Clinic and that reported by others. We also observed that patients with more severe fatty liver disease had lower Vitamin D concentrations. Others have shown that replacing Vitamin D in patients with cirrhosis is effective and even patients with Vitamin D replete status have lowering of Vitamin D over time if not supplemented.

One of the measures of liver injury in NAFLD is the plasma concentration of ALT and we will use this to follow patients as is currently done as standard of care. All patients in the Metabolic Liver Clinic are being routinely screened for Vitamin D deficiency as standard of care and treatment is being started with oral supplementation, but there are not standardized protocols to determine success of therapy. We hypothesize that patients with NAFLD with low Vitamin D levels will respond appropriately to Vitamin D supplementation for 6 months.


Eligibility Criteria:
Inclusion Criteria:

* Adults of age 18 or greater
* Diagnosis of fatty liver disease with a low Vitamin D level (\< 30 ng/dl) in the past 6 months
* Able to give consent

Exclusion Criteria:

* Those currently receiving Vitamin D supplementation
Post Marketing Study for the Evaluation of Predictix Antidepressant Clinician Software Support Tool in Prescribing Antidepressant Medication/s for the Treatment of Patients Suffering From Major Depressive Disorder

The study is designed as an open label, one arm study. Up to 30 eligible patients will be enrolled, for whom the Predictix Antidepressant Software tool will be used when prescribed with a medication for their Major Depressive Disorder, by their treating physician.

Visits will include the completion of several questionnaires designed to answer the study objectives, either as self-reported by the subjects and/ or by the clinician.

The study will enroll up to 30 eligible patients, for whom the Predictix Antidepressant Software tool will be used when prescribed with a medication for their Major Depressive Disorder, by their treating physician.

A treatment cycle will include four to five visits: Information consent and oral sampling, Baseline, 4 and 8 weeks. At least one completed cycle per patient is required for a patient to be included in the analysis as study completed.

The treating physician will review and approve each subject's eligibility prior to his/ her entrance to the study and will review the Predictix Antidepressant software tool report prior to treatment start.

Visits will include the completion of the Taliaz Ltd. Physician Form and several questionnaires designed to answer the study objectives Usability and satisfaction questionnaire/s will be analyzed for Usefulness, Satisfaction, Ease of Use and Learnability of the system.

Eligibility Criteria:
Inclusion Criteria:

* Male and female at the age of 18 - 75 years old
* Indication of MDD diagnosis per DSM V
* Rule out other causes of depressive symptoms other than MDD apart from General Anxiety Disorder as authentified by the MINI\*) (by Sheehan and Lecrubier ).

  \*Up to a maximum of 15 completed GAD pts
* Ability to read, understand and sign an informed consent document

Exclusion Criteria:

* Patient is diagnosed with other major psychopathologies (i.e. schizophrenia, bipolar disorder, psychotic depression, geriatric depression)
* Patient requires antipsychotic medication or mood stabilizers
* Patient is at substantial suicidal risk as judged by the treating physician
* Patient has attempted suicide in the past year.
* Patient has any current unstable medical condition or surgical illness
* Patient has history of seizure or convulsions.
* Patient has history of drug abuse or alcoholism in the last 6 months
* Inadequate communication with the patient
* In the investigator's judgement, patient is not able to provide written informed consent
* Pregnant women
Total Occlusive Ionic Silver-containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection

The patients were randomized into 3 groups: those patients undergoing a ionic silver-containing dressing (ISD) (Group 1), those undergoing a Mupirocin ointment application (MOA) (Group 2) and those using a conventional dressing (Group 3) in the surgical wound after finishing an elective colorectal surgery.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of colorectal neoplasms and plans to undergo an elective surgery with curative aims.
* Open surgical approach

Exclusion Criteria:

* Anastomotic leak
* Mortality
* Lost to follow-up
Effects of Nerve Block on Knee Function After Knee Replacement

Early physical therapy after knee surgery is very painful on top of pain from surgery. Pain following surgery can limit recovery. One way to treat pain is by giving intravenous (IV) pain medication with morphine. Another method is to use a "nerve block" which involves placing a thin catheter (tube) into the lower back near the nerves that sense pain in the knee and give a local anesthetic to numb the nerves. Sometimes both methods are used together. This research is being done to determine whether nerve blocks with a local anesthetic improve knee recovery in addition to providing pain relief as compared to IV pain medicine alone


Eligibility Criteria:
Inclusion Criteria:

* Age 21-80 year old
* ASA Physical Status ASA I and II
* Mentally competent
* Intellectually competent
* Body mass index \<35
* No severe cardiac diseases
* No severe pulmonary diseases
* Unilateral knee disease
* No other lower extremity joint disease
* No chronic narcotic therapy or illicit drug use

Exclusion Criteria:

* Age \<21 or \>80 year old
* ASA Physical Status \>ASA II
* Mentally incompetent
* Intellectually incompetent or cognitively impaired
* Non-English speaking patient
* Worker's compensation patient
* Body mass index \> 35
* Bilateral knee disease
* Has other lower extremity joint disease
* Severe cardiac diseases
* Severe pulmonary diseases
* Chronic narcotic therapy or illicit drug use
* Pregnancy
Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease

An assessment of the efficacy of topical tacrolimus in the treatment of cutaneous crohns disease


Eligibility Criteria:
Inclusion Criteria:

* willingness and capability to follow the study procedure
* confirmed diagnosis of Crohn's Disease of at least 3 months duration confirmed by radiography, endoscopy or pathological examination
* required to have a skin manifestation of Crohn's disease
* required to give written informed consent
* both male and female subjects with reproductive potential required to be on an acceptable form of birth control for the duration of the study
* long-standing, concomitant immunosuppressive therapy was allowed if the dose was stable and not controlling the skin problem

Exclusion Criteria:

* known sensitivity to tacrolimus
* change in aminosalicylate dosage in the four weeks prior to screening
* on oral steroids at over 40mg per day
* been commenced on methotrexate, azathoprine or ciclosporin within the last two months
* commenced on a a TNF-alpha monoclonal antibody within the three months prior to screening
* patients having had a stoma fashioned less than three months before enrolment
* patients with an immunocompromising disease
* patients with a diagnosis of malignancy within the last five years
* patients with any other condition, past or present treatment thought by the investigator to render the subject ineligible for the study