cyrilzakka/clinical-trials huggingface dataset:
Evaluating the Efficacy of Fenestrations in Tube Shunt Implants During the Early Postoperative Period

This study evaluates two different methods of controlling intraocular pressure in nonvalved aqueous tube shunts immediately after implantation; needle fenestrations or a suture wick.

This is a prospective, randomized control study of glaucomatous eye undergoing tube shunt implantation using a nonvalved implant for poorly controlled glaucoma of any type. Eyes scheduled to receive a nonvalved tube shunt implant will be randomized to receive either needle fenestration(s) or a suture wick using a single 10-0 vicryl anterior to the ligature. The operative quadrant will be imaged using anterior-segment optical coherence tomography at pre- and post-operative visits.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* Eyes that have poorly controlled glaucoma requiring a tube shunt implantation
* Willingness to participate in the study and sign informed consent

Exclusion Criteria:

* Concurrent surgery except phaco/intraocular lens
* Any abnormality preventing reliable applanation tonometry
* Eyes with exposure limitation (tight lids, deep orbits) that would make performing the anterior segment optical coherence tomography difficult
Short Term Effect of Smoking Cessation on Human Metabolism

Investigating the short term smoking cessation on metabolism, examining of participant of smoking cessation workshops and former participants' file survey for metabolic aspects

Objective: To examine metabolic aspects occurring during the first 6-12 months following smoking cessation in participants of smoking cessation workshops.

Design: A two armed study: prospective and retrospective. Prospective: Weight, BMI, waist circumference and waist: hip ratio were measured before, during and 6 months post cessation program. Retrospective: Blood test data for Blood fasting glucose (BFG) and lipid profile from the year preceding the workshops and the year after them were analyzed from participants' files. Smoking status was verified by phone conversation.

Eligibility Criteria:
Inclusion Criteria:

* Volunteers who were recruited from the smoking cessation workshops of the Meuhedet HMO (Israeli Health Services) during 2016-2017.

Exclusion Criteria:

* Candidates with benign tumors, bariatric surgeries, and endoscopic bariatric procedures before or during the study period were excluded
Outcomes of a Novel Technique of Mini- Incision and Self-Express (MISE) for Breast Abscess

Conventional techniques for treatment of breast abscess, such as incision and drainage/percutaneous drainage, have disadvantages. Bedside Mini-Incision and Self-Express (MISE) is a novel technique for breast abscess. The outcomes of MISE were compared to the conventional techniques.

outcomes such as recovery time, duration of antibiotics use etc will be compared between the various groups of intervention.

Eligibility Criteria:
Inclusion Criteria:

* Patients with a pathologically confirmed breast abscess and
* presenting at KK Women's and Children's Hospital, Singapore

Exclusion Criteria: Patients with:

* mastitis
* granulomatous mastitis
* breast fillers with infection
* ruptured abscess prior to intervention
* other interventions or bilateral breast infection
Efficacy of Preprocedural Diclofenac in Males Undergoing Double J Stent Removal Under Local Anesthesia

Double J (DJ) stents are placed following upper urinary tract surgeries. DJ stents are usually removed under local anesthesia using rigid cystoscope. Patients experience a lot of pain during this procedure and also continue to have discomfort during voiding for few days. The use of lignocaine jelly during this procedure is not very effective. Use of diclofenac suppository during flexible cystoscopy has been proven to be effective. This study was done to assess the effect of oral diclofenac in pain relief in patients undergoing DJ stent removal by rigid cystoscopy when compared to placebo and to assess its safety in these patients

Consecutive consenting male patients undergoing DJ stent removal under local anesthesia during 2014-15 were enrolled. Patients were randomized to receive 75 mg oral diclofenac or placebo 1 hour prior to procedure by double blind randomization. Intraurethral 2% lignocaine jelly (25 ml) was used in both groups. Pain during rigid cystoscopy, pain at first void and at 24 hours after cystoscopy was assessed using visual analogue scale \[VAS\] (0 to 100). Adverse reactions to diclofenac and episodes of acute urinary retention, if any, were assessed.

Eligibility Criteria:
Inclusion Criteria:

All consecutive consenting male patients aged more than 18 years, undergoing DJ stent removal under local anesthesia (2% Lignocaine jelly) during the study period will be included.

Exclusion Criteria:

* Patients unable to understand visual analogue pain score
* Age \< 18 years
* Presence of Lower Urinary Tract Symptoms prior to surgery
* Presence of prostatitis or urethral stricture during cystoscopy
* Patients with renal failure (Serum creatinine \> 1.3 mg/dl)
* Patients on concomitant nephrotoxic drugs
* Patients with history of peptic ulcer or upper gastrointestinal bleed or upper abdominal surgeries
* Loss to follow up at 24 hours following DJ stent removal
Effect of Sensory Integration in Diplegic Cerebral Palsy

The purpose of this study is to compare the effects of sensory integration therapy (SIT) applied in addition to neurodevelopmental treatment (NDT) on Motor Function, Balance, and Trunk Control in diplegia cerebral palsy

Cerebral palsy is the most frequent motor disability affecting children. The condition is characterized by problems with postural control and balance, which are due to the central nervous system being compromised by a brain lesion.

In sensory processing, the steps include receiving, organizing, and interpreting sensory information, followed by generating an appropriate response. Children develop motor skills through sensory experiences. Sensory integration therapy leads to enhanced body awareness, motor planning abilities, and coordination between both sides of the body.

Literature studies have demonstrated the effectiveness of sensory integration therapy in improving motor functions in children with diplegia type CP. However, there is a notable lack of research on how sensory integration therapy, in addition to neurodevelopmental treatment (NDT), affects balance and trunk control in these children. This study aims to bridge this gap by evaluating the impact of sensory integration therapy on gross motor function, balance, and trunk control in children with diplegia type CP when used as an adjunct to NDT.

Eligibility Criteria:
Inclusion Criteria:

* Participants must be between the ages of 4 and 17.
* Participants must be classified as Level II, III, or IV according to the Gross Motor Function Classification System (GMFCS).

Exclusion Criteria:

* Participants who had previously received sensory integration therapy, - Undergone Botulinum Toxin-A injections, or surgical interventions in the past year.
* Participants who were using pharmacological agents affecting muscle tone.
* Participants with an uncontrolled history of epilepsy.
* Participants who were unable to attend the study regularly.
Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly

This study's primary objective is to determine the independent and combined effects of progressive resistance muscle strength training and testosterone on the development of sustainable improvements in physical function.


Eligibility Criteria:
Inclusion Criteria:

The study will be limited to those patients who are metabolically stable and free of metastatic cancer and limiting end organ disease. Their total serum testosterone must be less than 480 and PSA less than 10.

Exclusion Criteria:
Preoperative Chemoradiotherapy With Capecitabine Plus Irinotecan in Rectal Cancer

This study is to evaluate the pathologic complete response rate to pre-operative concurrent chemoradiotherapy with capecitabine plus irinotecan in resectable rectal cancer

This study is an open-label, single center, nonrandomized phase II study. Daily fractions of radiotherapy at 1.8 Gy to total of 45 Gy to tumor and draining lymph nodes and followed by a coned-down boost of 5.4 Gy to the tumor were delivered concurrently with chemotherapy.

Chemotherapy starts at day 1 of radiotherapy. Capecitabine is administered orally at a dose of 825 mg/m2 twice daily during weekdays (Monday to Friday) every week during radiotherapy. Irinotecan 40 mg/m2 is given intravenously once a week (D 1, 8, 15, 22 \& 29).

Six ± 2 weeks after completion of chemoradiotherapy, curative surgery is performed.

Post-operative chemotherapy with capecitabine will be given to all patients 3-6 weeks after surgery. Capecitabine 1,250 mg/m2 twice daily on days 1-14 every 21 days will be administered for 18 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed adenocarcinoma of the rectum
* Distal margin of tumor located from 0 to 8 cm from anal verge
* Tumor must be clinically resectable by surgery and R0 resection must be most likely
* ECOG performance status 0-2
* No prior chemotherapy, radiotherapy to pelvis, and immunotherapy
* Adequate organ functions
* Patients must sign an informed consent

Exclusion Criteria:

* Malignant disease of the rectum other than adenocarcinoma or arisen from chronic inflammatory bowel disease
* Any unresected synchronous colon cancer
* Any distant metastasis
* Intestinal obstruction or impending obstruction, but decompressing colostomy is permitted
* Any previous or concurrent malignancy other than non-melanoma skin cancer or in situ cancer of uterine cervix
* Any other morbidity or situation with contraindication for chemoradiotherapy
* Patients have history of significant gastric or small bowel resection, or malabsorption syndrome, or other lack of integrity of the upper gastrointestinal tract that may compromise the absorption of capecitabine
* Pregnant or lactating women or patients of childbearing potential not practicing adequate contraception
Clinical Study to Evaluate the Efficacy and Safety of DSXS in Patients With Mild to Moderate Plaque Psoriasis

The purpose of this study is to evaluate the therapeutic efficacy and safety of DSXS compared to a Placebo (vehicle) in patients with mild to moderate plaque psoriasis.

To evaluate the therapeutic efficacy and safety of dsxs topical spray, 0.15% (Taro Pharmaceuticals, U.S.A., Inc.) compared to a Placebo (vehicle) spray (Taro Pharmaceuticals, U.S.A., Inc.) in patients with mild to moderate plaque psoriasis.

Eligibility Criteria:
Inclusion Criteria:

* male and non-pregnant females, 12 years of age or older, with a confirmed diagnosis of mild to moderate plaque psoriasis

Exclusion Criteria:

* patient is\< 12 years old.
Real World Study of Regorafenib Versus Fruquintinib in Colorectal Cancer

This is an observational, ambispective cohort study. The aim is to compare the efficacy and safety of regorafenib versus fruquintinib conducted in China. About 268 eligible metastatic colorectal cancer patients after second-line therapy will be assigned to receive either regorafenib or fruquintinib, based on decision of the gastrointestinal physician according the patients' condition.


Eligibility Criteria:
Inclusion Criteria:

1. signed and dated informed consent.
2. Diagnosis of histologically confirmed colorectal cancer, stage IV.
3. after second-line therapy.
4. gastrointestinal physician prescribed to receive regorafenib or fruquintinib according the patients' condition.

Exclusion Criteria:

1. received regorafenib or fruquintinib before third-line therapy.
2. the clinicopathological characteristics and previous therapy were unknown.
3. regorafenib or fruquintinib treatment is less than one cycle in the historical cohort.
Research of Pathological Imaging Diagnosis of Ocular Tumors Based on New Artificial Intelligence Algorithm

The purpose of this study is to establish a standardized process for obtaining digital pathological image information of ocular tumors; use modern pathological techniques to obtain the co-expression information of multiple biomarkers in the pathological tissues of ocular tumors, and finally construct standardized digital ocular tumors with biomarkers Pathology image database.

This study is a prospective study. Patients with common and representative ocular tumors in the Department of Ophthalmology, Peking University Third Hospital, will be selected and enrolled after informed consent to collect basic clinical information, preoperative blood samples, and ocular tumors Obtain pathological image annotation data and genomics-related data from ocular tumor tissue specimens, use blood samples for genomics information analysis, provide multi-dimensional data for the development of artificial intelligence algorithms, and establish artificial intelligence-assisted image data for eye tumors Standardize the process and establish a multi-modal ocular tumor standardized database of "clinical information-tissue samples-pathological images-genomics data". The database and the diagnosis system are correlated with each other to provide optimal image data for later machine learning and related algorithm establishment, and finally the investigators will be completed the design of a new artificial intelligence-assisted diagnosis system for eye tumors.

Eligibility Criteria:
Inclusion Criteria:

1. Patients diagnosed with eye tumors and undergoing eye tumor surgery.
2. Patients sign informed consent for sample collection and sample transfer agreement, and can cooperate with long-term regular follow-up requirements.

Exclusion Criteria:

1. Patients who are unable to undergo tumor surgery or retain samples due to various reasons .
2. Patients who are positive for hepatitis B, HIV, and syphilis.
3. Patient compliance is poor.
The Effect of a Tidal Model-Based Approach Applied During Home Visits on Mental Health Parameters and Hospital Admission Frequency in COPD Patients

Despite the recent increased interest in identifying the needs of COPD patients and improving disease management, monitoring the psychosocial well-being of these individuals remains insufficient. Nursing care that incorporates psychosocial approaches plays a critical role in halting disease progression and controlling symptoms in COPD management. The Tidal Model emerges as a vital tool in enhancing patient independence throughout this process. This recovery-oriented model provides a robust framework for individualized care by thoroughly analyzing patients' needs. It likens life to an ocean voyage and emphasizes learning how to cope with challenges encountered during this journey. The difficulties experienced by individuals with chronic illness and respiratory limitations are aligned with the Tidal Model's concepts of chaos and tides.

Current studies indicate that psychological interventions for COPD patients have limited effectiveness in reducing psychological morbidity. Additionally, while interventions such as mindfulness-based and digital approaches show promise, their effects have not consistently proven significant across studies. This underscores the ongoing challenge of effectively addressing the psychological aspects of COPD and highlights the need for further research to identify more robust interventions.

In this context, guided by the philosophy of the Tidal Model that emphasizes "helping individuals with problems in living," it has been hypothesized that the model would be suitable for use with individuals with COPD. The current study aims to evaluate its effectiveness.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 years or older
* Clinical diagnosis of COPD for at least one year
* No cognitive or sensory disabilities
* No prior participation in any psychosocial support training
* GOLD stage 'E' COPD
* Availability of a private or suitable room for interviews
* Residence within the city center

Exclusion Criteria:

* Age under 18 years
* Declined participation in the study
* Cognitive or sensory disabilities
* Prior participation in any psychosocial support training
* GOLD stage 'A' or 'B' COPD
* Unsuitable environment for conducting interviews
* Security concerns for the researcher
* Residence outside the city center or in rural areas
Assessment of the Effect of a Dermatology-Oriented Spa Therapy on the Quality of Life of Patients with Psoriasis

Evaluation of the effect of a dermatology-oriented spa therapy at 4.5 months on the quality of life of patients suffering from psoriasis

BAREGES is a:

prospective, before/after, cohort follow-up study with repeated measurements monocentric study with the dispensation of a 3-week dermatolgy-oriented spa therapy in Barèges

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years Patient with psoriasis Stable treatment in the last 6 months. DLQI \> 10 Patient presenting an indication for thermal treatment focused on dermatology (possible dual orientation).

Patient affiliated to the social security system or such a system Available for an 18-day spa treatment and a 9-month follow-up For women of childbearing age: effective contraception Patient information and informed consent signature

Exclusion Criteria:

Contraindication to thermal treatment (e.g., ongoing chemotherapy/radiotherapy, uncontrolled progressive neoplasia, progressive heart disease, etc., according to the investigator's assessment) Predictable intolerance to thermal treatments (intolerance to heat, baths, etc.) Patient who has already undergone a dermatology-oriented spa treatment within the current thermal season Subject already included in an interventional clinical research protocol Persons referred to in articles L1121-5 to L1121-8 of the "Code de la Santé Publique" (pregnant women, women in labour and parturient and nursing mothers, persons deprived of liberty by judicial or administrative decision, persons subject to a legal protection measure or not being able to verbally communicate their agreement, minor)
An Open-Label Study Of Pregabalin In Subjects With Refractory Partial Seizures

The main purpose of this trial is to allow continued access to pregabalin to Canadian subjects who participated in global pregabalin epilepsy studies 1008-010; 1008-035; 1008-114 and 1008-164 and to continue to study the long term safety of pregabalin administered as adjunctive therapy at dosages from 150 mg/day to 600 mg/day in Canadian subjects with refractory partial seizures.


Eligibility Criteria:
Inclusion Criteria:

* Must have completed Pfizer open-label studies 1008-010; 1008-035; 1008-114 or 1008-164 and wishes to continue receiving open-label pregabalin
* Must have responded favorably to pregabalin in Pfizer open-label study 1008-010, 1008-035, 1008-114 or 1008-164 and in the clinical opinion of the investigator continued treatment with pregabalin is in the the patient's best medical interest

Exclusion Criteria:

* Is pregnant or is considering becoming pregnant during the course of the study
* Experienced a serious adverse event during open-label Pfizer study 1008-010, 1008-035, 1008-114 or 1008-164
Hens Hatching Hope

The study is a prospective community-cluster non-randomized trial that will evaluate the effectiveness of a program that will provide 30-day egg vouchers to mothers of 6 to 24 month-old children living in rural areas of Intibucá, Honduras.


Eligibility Criteria:
Inclusion Criteria:

* Healthy children ages 6 to 24 months at the time the study begins
* No cerebral palsy, birth defect or condition that may affect their growth or development.
* Children living in the department of Intibucá, Honduras

Exclusion Criteria:

* Children from families that are considering leaving the region within the next 12 months
* Known egg allergy
The Role of Naps and Overnight Sleep on Cognitive Learning in Preschoolers

The goal of this research is to understand the role of sleep on memory function in early childhood. Specifically, we seek to examine how promoted naps vs. promoted waking in habitual and non-habitual napping children may impact overnight sleep physiology and subsequent memory consolidation.

With time spent awake, sleepiness increases (i.e., sleep pressure; Borbely, 1982). In young adults, naps following sleep deprivation have significantly elevated slow wave activity (SWA; 1-4 Hz) relative to naps following normal overnight sleep (Werth et al., 1996). Similarly in preschool children, overnight sleep following nap deprivation yields significantly greater SWS relative to when a nap was taken earlier in the day (Lassonde et al., 2016). This impact on subsequent sleep physiology suggests that naps may be an extension of overnight sleep. How napping status (i.e., habitual and non-habitual napping) impacts overnight sleep physiology and subsequent memory consolidation is unknown. Thus, this study aims to investigate how napping vs. staying awake in habitual and non-habitual napping children may impact overnight sleep physiology and subsequent memory consolidation.

Eligibility Criteria:
Inclusion Criteria:

* Family lives within 30 miles of UMass Amherst
* Is 33-71 months at the time of enrollment
* Meets the definition of a habitual (5+ naps/week) or non-habitual (\<2 naps/week) napper
* Normal or corrected-to-normal vision and hearing
* Access to a computer with an internet connection for online sessions with the research team.

Exclusion Criteria:

* Diagnosis of any sleep disorder (other than mild parasomnia which is routine at this age) past or present
* Current use of psychotropic or sleep-altering medications
* Traveling beyond 1 time zone within 1 month of participation
* Fever or symptoms of respiratory illness at the time of participation
* Diagnosed developmental disability