cyrilzakka/clinical-trials huggingface dataset:
EGD-assisted Bowel Preparation for Colonoscopy

Adequate bowel preparation is of critical importance for colonoscopy. Particularly among hospitalized patients, inadequate bowel preparation for colonoscopy may arise due to patient intolerance to prescribed laxative regimen, elderly population, and co-existing conditions that impair the ability to ingest a large-volume laxative regimen. Improvements in bowel preparation for colonoscopy in hospitalized patients would likely improve patient care and reduce hospital costs. The purpose of this study is to determine if administering a portion of the bowel purgative via EGD could improve colonoscopy preparation in hospitalized patients.

In this randomized controlled trial in hospitalized patients, patients in whom colonoscopy was anticipated the day following EGD were consented and randomized to either standard prep by mouth (split-dose PEG) or intervention group (instillation of the first 2 liters of Nulytely solution through the channel of the endoscope into the duodenal bulb, then continue standard prep). Data is collected on quality of prep and patient satisfaction in both groups.

Eligibility Criteria:
Inclusion Criteria:

* hospitalized patients
* having EGD and expected to have colonoscopy the following day
* written informed consent

Exclusion Criteria:

* unable to tolerate EGD-assisted prep administration
Can we Use a Simple Blood Test to Reduce Unnecessary Adverse Effects From Radiotherapy by Timely Identification of Radiotherapy-resistant Rectal Cancers? MeD-Seq Rectal Study

Chemoradiation therapy (CRT) followed by surgery is currently the standard of care to treat patients with locally advanced rectal cancer (LARC). CRT reduces local recurrences, but is associated with significant damage to the surrounding healthy tissue that can severely impact quality of life. Additionally, a proportion of patients (hardly) benefit from CRT. We aim to develop a diagnostic innovation, which can enable a more selective and thereby more effective use of the available therapies for rectal cancer patients.

The objective of this study is to investigate whether patients can be identified who will response to CRT prior to start of the CRT in rectal cancer and therefore avoid possible severe side effects in patients who will not reponse on CRT.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years
* Histologically confirmed rectal adenocarcinoma
* Scheduled for neoadjuvant chemoradiation
* Written informed consent.

Exclusion Criteria:

* Scheduled to another neoadjuvant schedule that comprises systemic chemotherapy or short-course radiation
* Not able to read or understand Dutch language or mentally not capable.
Evaluation of Concordance Between Exhaled Air Test (eBAM-CoV) and RT-PCR to Detect SARS-CoV-2

During the COVID-19 pandemic, testing primarily relied on the use of nasopharyngeal swabs to detect the SARS-CoV-2 virus, responsible for the disease. However, this technique has several limitations, including the variable quality of swabs, its invasive nature, and arbitrariness in the choice of the number of cycles. Furthermore, it does not allow for the detection of viral proteins.

To overcome these limitations, researchers developed the eBAM-CoV test, patented for the detection of viral proteins in the exhaled air of COVID-19 patients. This portable device provides an immediate assessment of the "viral load" with both quantitative and qualitative results, showing promise for early virus detection.

The researchers hypothesize that the eBAM-CoV test is likely to exhibit a satisfactory concordance with the reference RT-PCR test in the detection of COVID-19, especially among symptomatic patients or closed contacts.


Eligibility Criteria:
Inclusion Criteria:

* Adult male or female patients over 18 years of age (≥)
* Suspected of being infected with COVID-19 (symptomatic or contact case) and consulting for RT-PCR screening.

Exclusion Criteria:

* Inability to understand the procedures to use the device
* Patient participating in an another interventional study
* Patient in exclusion period determined by another study
* Patient under court protection or guardianship
* Patient/trusted person/legal representative/family member for whom it is impossible to give informed information.
* Pregnant, parturient or breast-feeding patient
A Quality Rating Scale for Patients in Complex Situations

The prevalence of multimorbid patients and complex care is increasing in France and elsewhere in the world. It concerns 60% of the over 65 years old. Comprehensive care, the involvement of the patient and his caregivers appear as the solutions for the management of these new care situations. The structures of multi-professional grouping, developing a coordinated exercise (GECO), appear as the privileged place to take care of these patients. These structures become the main place of exercise in France (improved working conditions for professionals, financial incentives, public policy, etc.); they have shown their ability to formulate patient care protocols, to produce coordinated exercise, to better involve the patient and caregivers in their care. The question of improving the quality of care arises. To date, there is no data on the subject apart from some evaluations mainly medico-economic.

The patient's place in the evaluation showed his interest with the existence of a proven correlation between patient satisfaction in particular and his compliance and health outcomes.


Eligibility Criteria:
Inclusion Criteria:

* Patient followed in the primary care center, able to participate, speaking and understanding French, and being in a complex care situation, benefiting from a multi-professional care (at least two professionals different from the center including the general practitioner).

Exclusion Criteria:

* Patient not in a complex care situation
* Patient followed only by the general practitioner of GECO
* Refusal of participation
A Novel Approach Integrating Magnetic Resonance Imaging (MRI) Data and Artificial Intelligence for Predicting the Success Rate of Vaginal Delivery in Pregnant Women

The aim of this study was to use MRI imaging to accurately scan the pregnant woman's pelvis and fetal skull, build a 3D model of them, and combine with artificial intelligence to develop an accurate tool to predict the success rate of vaginal delivery.


Eligibility Criteria:
Inclusion Criteria:

* Full-term.
* Single fetus, head first.
* Pregnant women have vaginal couvade wishes.
* Complete clinical data of pregnant women.

Exclusion Criteria:

* Pregnancy with serious medical and surgical diseases.
* Abnormal fetal position (such as transverse, breech, etc.).
* Twin or multiple pregnancies.
* Vaginal couvade contraindications such as placenta previa.
Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients

The global prevalence of spinal cord injury is estimated between 236 to 4187/Million. A spontaneous recovery of the sense-motoric function is decreasing with the time after injury and is only seen sporadically after 1 to 2 years. Treatment options are mainly limited to improvement of the quality of life.

The present prospective randomized study is intended as a double-blind, placebo controlled multi-center investigation. Patients suffering from chronic paraplegia (lesion between THII and THX, ASIA A = complete central lesion) at least for 1 year after the initial trauma without spontaneous remission of the last 6 months are considered to be included in the study. Meeting the inclusion criteria and signing the informed consent, patients are treated in one of the two study centers. At study inclusion, a baseline evaluation comprising neurological, neurophysiological, functional and clinical investigation is performed. Patients dedicated to the ESWT intervention group will be treated once a week over 6 weeks with local non-invasive low energy extracorporeal shockwave therapy (=6 treatments with an electrohydraulic device). The follow-up will include neurological, neurophysiological, clinical as well as functional evaluation at the time points 6 weeks, 3 months and 6 months. Additionally, patients will be provided with a diary for documentation of drug adaptation, grade of spasticity and pain. Those patients dedicated to the Placebo ESWT group, will receive the identical scheme in treatment (but without application of shockwaves) and follow-up as the patients in the ESWT group. However, after positive completion of the study, these patients will be offered ESWT as well.


Eligibility Criteria:
Inclusion Criteria:

* patients with a spinal cord injury classified as ASIA A between the level of THII to THX (complete central lesion)
* at least 1 year after trauma
* no signs of spontaneous recovery over the last 6 months
* signed informed consent

Exclusion Criteria:

* central therapies over the last 6 months (eg stem cells, electro-therapy)
* Baclofen pump
* Joint contraction lower limb \> 40° (hip or knee)
* Body weight \> 135 kg
* Body height \> 202 cm
* non-compliant patients
* Decubital ulcers at grade II or higher
* participation in an other clinical trial within the last 6 months
* Co-morbidities which make study completion doubtful or impossible
* Additional neurological diseases which may lead to further damage to the nerval system
* Malignant tumor
The Pandemic Stress Vaccine: A Resource to Enhance the Resilience of Healthcare Workers Facing an Infectious Outbreak

The purpose of this study is to determine the effects of an interactive, computerized learning resource designed to increase resilience in hospital-based health care workers preparing for an influenza pandemic. The effects of the learning resource will be compared to a non-interactive learning resource condition and a control condition. It is hypothesized that (a) online pandemic-related education reduces absenteeism and interpersonal problems for healthcare workers (HCWs), and improves their pandemic self-efficacy in the short and long-term, and (b) an interactive format for online education is necessary for its benefits.


Eligibility Criteria:
Inclusion Criteria:

* employee or professional staff of a hospital

Exclusion Criteria:

* unable to read and write English
The Influence of a High Intensity Physical Activity Intervention on a Selection of Health Related Outcomes: An Ecological Approach

The purpose of this study is to determine whether a High Intensity exercise intervention can elicit cardiovascular disease protection in adolescents.


Eligibility Criteria:
Inclusion Criteria:

* Healthy
* 15 - 18 yer old that are capable of performing vigorous exercise

Exclusion Criteria:

* Any health condition that would prevent them from undertaking vigorous exercise
Primary Care Community Partnerships to Prevent Diabetes

The purpose of this study is to determine if providing free-of-charge access to a group-based lifestyle intervention delivered in partnership with the community is cost-effective for the prevention of type 2 diabetes.

Randomized controlled trials have shown that modest lifestyle changes can prevent or delay the onset of diabetes in adults with pre-diabetes. Unfortunately, despite the increasing prevalence of pre-diabetes and diabetes in all facets of the population, intervention programs needed to achieve these goals are costly and remain unavailable in most clinical settings. Over the past 3 years, we have demonstrated the feasibility of training community instructors to deliver a group-based adaptation of the Diabetes Prevention Program (DPP) lifestyle intervention. In this pilot research, this new delivery model achieves a level of weight reduction that was associated with diabetes prevention and improved cardiometabolic risk factor control in the DPP. This new, large-scale randomized effectiveness trial is designed to evaluate the costs and effectiveness of a partnered approach to identify adults with pre-diabetes in primary care settings, deliver brief advice for diabetes prevention, and provide access to a group-based adaptation of the DPP lifestyle intervention offered by the community. This study will compare costs and outcomes to a standard care, brief clinical counseling approach delivered by Registered Dietitians.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* Body-mass index of 24 kg/m2 or greater
* Fasting Blood Glucose 100 - 125 mg/dl, OR 2-hour Post-challenge Capillary Glucose 140 - 199 mg/dl

Exclusion Criteria:

* Cancer requiring treatment in the past 5 years
* Uncontrolled hypertension: systolic blood pressure \>180 mmHg or diastolic blood pressure \>105 mmHg
* Heart attack, stroke, or transient ischemic attack in the past 6 months,
* Chronic obstructive airways disease or asthma requiring home oxygen
* Other chronic disease or condition, such as advanced arthritis, that could limit ability to become physically active or limit life span to \<5 years
* Pregnancy
* Existing diagnosis of diabetes mellitus
* Fasting capillary blood glucose \> 125 mg/dl
* 2-hour post-challenge capillary blood glucose \> 199 mg/dl
* History of anti-diabetic medication use (oral agents or insulin) except during gestational diabetes
* Self-report of a medication known to lead to hyperglycemia (oral steroids, antipsychotics, anti-epileptics)
* Self-report of disease associated with disordered glucose metabolism: Cushing's syndrome; acromegaly; pheochromocytoma; chronic pancreatitis
The Effectiveness of the Android Application as a Pharmaceutical Education Tool in Hypertensive Patients

Hypertension is a worldwide public health challenge due to its high prevalence and along with increased risk of complications of other diseases that are more dangerous if not managed properly. An estimated 1.4 billion people worldwide have high blood pressure, but only 14% can control it. Knowledge of hypertension in patients with hypertension can prevent complications through hypertension treatment. Increasing knowledge can be done by providing education in the form of counseling by pharmacists to hypertensive patients. Counseling activities carried out by pharmacists can be supported by a technological approach. One of the uses in smartphone technology is by creating an android-based mobile application that can be developed to support pharmaceutical care. Education conducted by pharmacists can increase knowledge that will affect hypertension treatment adherence, and this education can also improve blood pressure control so that it can improve the quality of life. The purpose of this study is to analyze the influence of the android application as a standard pharmacist education tool on knowledge as well as adherence and therapeutic outcomes of hypertensive patients, and quality of life related to the health of hypertensive patients compared to just providing standard education by pharmacists to hypertensive patients at the Primary Health Care. The method used in this study is a Quasi-Experimental with Pretest - Posttest Control Group Design. Samples were obtained by purposive sampling method at the selected Primary Health Care as the intervention group and the selected Primary Health Care as the control group. Pharmacist provides education to intervention groups with android applications as counseling aids and in control groups only standard counseling is provided. Pre-test data collection was done by taking primary and secondary data of patients at the first meeting and post-test data collection was taken prospectively through face-to-face interviews and questionnaires on hypertensive patients participants for three months by observing the influence of android applications as counseling aids on knowledge of hypertensive diseases, adherence to antihypertensive treatment, outcome therapy and quality of life.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged ≥ 18 years, male and female who are willing to be respondents.
* Patients diagnosed with hypertension or currently taking ≥ 1 antihypertensive drug.
* Hypertension patients who carry out routine control and receive anti-hypertensive drugs for at least 3 months at the Health Center.
* Not illiterate and owns a smartphone.
* Patients who are willing to participate in the study by signing an informed consent.

Exclusion Criteria:

* Physical and mental disabilities such as deaf, blind, and psychiatric disorders.
* The patient is pregnant
* Currently taking hormonal drugs and other routine drugs such as TB, HIV and AIDS drugs.
The Effect of Focused Lung Ultrasonography on Antibiotic Prescribing in General Practice

The goal of this randomised controlled trial is to determine if adults presenting with symptoms of an acute lower respiratory tract infection in general practice where the general practitioner suspects CAP, who have FLUS performed as an addition to usual care, have antibiotics prescribed less frequent compared to those given usual care only.


Eligibility Criteria:
Inclusion Criteria:

1. Age ≥ 18 years.
2. Acute cough (\< 21 days).
3. At least one other symptom of acute lower respiratory tract infection (LRTI).
4. The general practitioner suspects a bacterial community-acquired pneumonia.

Exclusion Criteria:

1. Previous antibiotic treatment for the current episode of acute LRTI.
2. The patient is not listed with the general practitioner (no medical record available).
3. The patient is not capable of understanding and signing informed consent.
4. The patient does not wish to participate in the study.
Effect of Deep Neck Flexors Biofeedback Training and Post Isometric Relaxation in Chronic Mechanical Neck Pain

This study will be conducted to explore the superiority of effectiveness between Muscle energy technique combined with Deep Neck Flexors training, MET alone, or DNF training alone in terms of pain intensity, neck function, forward head posture, cervical range of motion and Deep Neck Flexors Muscles endurance in patients with chronic mechanical neck pain(CMNP).

Patients will be grouped into three groups; each group composed of 15 patients suffering from CMNP. The personal history of each patient who participated in the study will be collected, the patient will receive an oral explanation of the procedures and signed a consent form . The weight and height of each patient will be obtained using the standard weight scale. The pain intensity level will be assessed via a visual analogue scale (VAS). The disability level will be assessed via neck disability index (NDI). The forward head posture will be assessed via photographic method of Craniovertebral angle (CVA) and the angle will be calculated by using kinovea software. The range of motion will be assessed via universal goniometer (UG). The endurance of the neck muscles will be assessed via pressure biofeedback unit (PBU). Assessment will be done before treatment and after 12 treatment sessions.

Eligibility Criteria:
Inclusion Criteria:

1. Age group 20-40 years of female and male patient.
2. Patient with neck pain duration more than 3 months and less than one year.
3. Subjects who could not maintain blood pressure at increments of 24 mmHg from the initial 20 mm Hg
4. Patients who have moderate neck pain and disability scoring 15 to 24 from 50 on neck disability index. .
5. Pain intensity more than 3 and less than 7 on visual analogue scale (VAS)
6. CVA less than 49°

Exclusion Criteria:

1. People with severe neck pain. (Disability scoring more than 25 on Neck Disability Index)
2. If they are participated in a neck rehabilitation program over the last 6 months
3. Major circulatory or respiratory disorder
4. Pregnant women or 3 months postnatal
5. Patient with structural instability and degenerative conditions of cervical spine.
6. Body Mass Index more than 30.
7. Post traumatic or infective conditions.
8. Any surgeries around cervical spine
9. Vertigo patient
10. Un-cooperative patient (Gupta et al., 2022).
Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study

The purpose of this pilot study is to determine if intravenous tranexamic acid (TXA) is effective for reducing blood loss during high risk surgical procedures related to placenta previa and placenta accreta. TXA is currently used in other types of surgery for patients who are expected to have a large blood loss, such as orthopedic or open heart surgery.

To date, no novel or pharmacologic methods of reducing blood loss have been described for women at risk for placenta accreta. Intravenous tranexamic acid (TXA), a drug with anti-fibrinolytic activity, is routinely used in elective orthopedic and cardiac surgery to reduce blood loss. Intravenous tranexamic acid is currently FDA approved for use in patients undergoing cardiac surgery or total knee arthroplasty or total hip arthroplasty to reduce peri- and post-operative blood loss and to reduce the need for blood transfusion. There has been growing interest in the application of tranexamic acid in obstetrics and gynecology. In multiple international studies, intravenous TXA has been shown to significantly reduce blood loss when given prophylactically with cesarean delivery or vaginal delivery without an increase in morbidity from adverse thrombotic events. TXA has not been studied in the particular population of patients requiring cesarean hysterectomy for placenta previa or accreta. This inexpensive, low risk medication has potential to greatly reduce perioperative morbidity and cost when used in a high risk obstetrical population.

Eligibility Criteria:
Inclusion Criteria:

* English and Spanish speaking pregnant women
* Any order pregnancy (singleton, twin gestation, etc)
* Suspected accreta based on ultrasound or MRI imaging studies
* All women evaluated for placenta accreta and deemed to be high risk for this disease (≥40% risk), meaning women diagnosed with a placenta previa and greater than or equal to 2 prior c-sections

Exclusion Criteria:

* Women less than 18 years of age
* Women with a personal history of venous or arterial thrombosis (deep vein thrombosis, pulmonary embolism, myocardial infarction, or stroke
* Women with a personal history of a high risk clotting disorder, such as anti-phospholipid syndrome
* Women who do not have a good understanding of either English or Spanish will be excluded.
* Women with defective color vision (color-blindness)
Optical Genome Mapping for the Diagnosis of Neurodevelopmental Disorders

to evaluate the ability of the Optical genome Mapping (OGM) approach to detect simple and complex constitutional chromosomal aberrations of clinical relevance, which had previously been identified with standard diagnostic approaches (karyotyping, FISH, CNV-microarray) in the context of neurodevelopmental disorders (NDDs) with/wo congenital anomalies (CA)


Eligibility Criteria:
Inclusion Criteria:

* subjects with neurodevelopmental disorders carrying a structural variant identified by standard cytogenetic analyses (Karyotyping/FISH/Chromosomal Microarray Analysis)

Exclusion Criteria:

* none
The Effect of Steep Trendelenburg Position on Neurocognitive Functions in Robotic Radical Prostatectomy Cases

The aim of this study is to evaluate the effects of the steep Trendelenburg position in robotic prostatectomy cases, where anesthesia depth is monitored using BIS and cerebral perfusion is tracked with NIRS, and to determine the incidence of neurocognitive dysfunction using the MoCA test in the postoperative period.

Steep Trendelenburg position and CO₂ pneumoperitoneum during robotic radical prostatectomy lead to significant changes in intracranial pressure and cerebral oxygenation, which may contribute to postoperative neurocognitive dysfunction (POCD). Monitoring anesthesia depth with Bispectral Index (BIS) and cerebral perfusion with Near-Infrared Spectroscopy (NIRS) may help detect early neurocognitive changes, and MoCA test assessments will reveal a measurable decline in cognitive function postoperatively.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 65 years
* ASA II-III risk score
* Patients scheduled for robotic radical prostatectomy
* Patients who voluntarily agree to participate

Exclusion Criteria:

* Age \< 65 years
* History of neurological or psychiatric disorders
* Inability to undergo robotic surgery
* Conversion to open prostatectomy during surgery
* Patients who do not consent to participate