cyrilzakka/clinical-trials huggingface dataset:
Patient-derived Organoids Predicts the Clinical Efficiency of Colorectal Liver Metastasis

Accumulating evidence indicates that patient- derived organoids (PDOs) can predict drug responses in the clinic. Metastasis is the main cause of death in colorectal cancer patients, and the treatment of patients with liver metastasis remains poor. Tumor heterogeneity is the cause of treatment failure. In this study, we aim the investigate the consistency of drug sensitivity for the matched primary and metastatic tumor in patients with liver metastasis.


Eligibility Criteria:
Inclusion Criteria:

* Histologically proven colorectal cancer with liver metastasis
* Aged between 18 and 70 years
* Written informed and signed consent
* Accessible to surgery sample of metastasis and primary tumor

Exclusion Criteria:

* Less than 18 years and older than 70 years
* Not able to give informed consent
* Not accessible to surgery sample
The Remote Family Support Programs for Eating Disorders

Eating disorders are serious mental health disorders associated with high levels of mortality, disability, physical and psychological morbidity, and impaired quality of life. Family members who spend the majority of their time with patients of eating disorders experience heavy psychological burden. Remote family support programs consist of interpersonal psychotherapy and family psychoeducation. This study aimed to examine the effectiveness of a remote family support program for eating disorders in an RCT (randomized controlled trial). The specific objective was to conduct a small pilot RCT of the remote family support program (n=28) compared with TAU (n=28).


Eligibility Criteria:
Inclusion Criteria:

* The research participants are parents of patients who have been diagnosed with an eating disorder by a physician or have symptoms of an eating disorder; parents may or may not be related by blood.
* The ABOS score measured by the research participants at enrollment is over 8 points.
* Patient age at enrollment ranged from 12 to 29 years.
* The patient has lived with their parents at the time of participating in this study and is expected to live with them during the investigation period.
* Patients may or may not undergo treatment.
* Patients with other psychiatric comorbidities are included.
* Participants with other psychiatric comorbidities are included.
* If multiple family members (e.g., parents) participated in this program, the primary participant is determined, and that person becomes the target research participant.
* Willingness to provide informed consent and comply with the trial protocol.

Exclusion Criteria:

* The participants cannot read or write in Japanese
* The participants cannot use the Zoom meeting system
* Researcher of this study and their families
Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCC

A two-part molecular epidemiological study will be conducted to comprehensively assess the association between miR expression and miR promoter methylation and the response to therapy and prognosis in primary, HPV-negative HNSCC patients. Part 1 will be a prospective collection of 25 pairs of fresh tumor-distant normal mucosal tissue in patients with HNSCC. Ultimately, 15 HPV-negative tumor-mucosal pairs will be utilized for discovery work in identifying miRs whose expression is up- or down-regulated in tumors. Part 2 will test the association between miR expression and miR promoter methylation, and therapeutic response and survival in all archived surgical cases of HPV-negative HNSCC at University of New Mexico Hospital (UNMH) collected after 1990.

\* Part 1, Prospective Collection of Fresh Tumor-Distant Normal Pairs

The investigators will prospectively collect 25 pairs of fresh HNSCC tumor-distant normal mucosal tissue.

\* Part 2, Retrospective Molecular Epidemiology Study of the Association of miRs with Therapeutic Response and Prognosis in HNSCC.

The investigators will comprehensively test the association between miR expression and miR promoter methylation, and the response to therapy and survival in all cases of surgical HPV-negative HNSCC at UNMH collected after 1990. Lip and nonkeratinizing nasopharyngeal cases will be excluded as these are etiologically distinct and related to cutaneous SCC or to EB virus infection, respectively. No cases will be excluded due to gender, age, race or ethnicity.

Eligibility Criteria:
Inclusion Criteria:

* Patients with a known or suspected diagnosis of HNSCC

  * Any primary site may be included, except nonkeratinizing nasopharyngeal SCC or lip SCC.
  * Patients are planned for diagnostic biopsies for suspected HNSCC, or for therapeutic surgery for HNSCC.
  * Patients are naïve to radiation to the head and neck, prior to research biopsies.
  * Patients have not received chemotherapy for the diagnosis of HNSCC, prior to research biopsies.
* Age \> 18 years.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
* Patients sign an informed consent, agreeing to fresh tumor biopsy as well as distant normal mucosal biopsy for purposes of described research. Research biopsies will be in addition to planned surgery. In cases where tumor resection is planned, a representative part of the tumor will be submitted for research purposes.

Exclusion Criteria:

* Nonkeratinizing nasopharyngeal carcinoma
* Lip squamous cell carcinoma
Expanded Access for CC-10004

This is an expanded access program (EAP) for eligible participants designed to provide access to CC-10004.


Eligibility Criteria:
Inclusion Criteria:

-

Exclusion Criteria:

-
EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation

The investigators are performing this research study to find out if intravenous (IV) methylphenidate (commonly known as Ritalin) can help people recover faster from propofol sedation. The investigators also want to know how IV methylphenidate acts in the brain and whether IV methylphenidate is safe to take with an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain by causing unconsciousness) without causing too many side effects. The brain's electrical activity will be studied and recorded using a machine called an electroencephalogram (EEG).

During this research study, participants will receive propofol, and propofol and IV methylphenidate together, at a high enough dose to achieve unconsciousness (make study participants "fall asleep"). During one visit participants will receive propofol and a saline placebo; during another visit participants will be given both propofol and IV methylphenidate together. The investigators will record EEG the entire time, The investigators will also ask some questions related to cognitive function.

Eligibility Criteria:
Inclusion Criteria:

* Between the ages of 18 to 45
* Normal body weight and habitus, BMI ≤ 30
* Non-smoker
* No history of taking stimulants
* American Society of Anesthesiologists (ASA) physical status classification P1

Exclusion Criteria:

• Chronic health conditions
Antibodies Causing Epilepsy Syndromes: The ACES Study.

The Antibodies Causing Epilepsy Syndromes (ACES) Study is a observational cohort study focusing on detection of auto-immune epilepsy in patients with epilepsy of unknown origin.

Recently new treatable causes of epilepsy have been identified. These disorders are caused by a disruption of the balance in the brain caused by inflammation. This inflammatory reaction is caused by an autologous reaction of the immune system to specific brain proteins. The body produces antibodies to specific parts of the brain. These disorders can lead to epilepsy, memory dysfunction and psychiatric problems. Recognition is necessary for good treatment. Mostly anti-epileptic drugs are insufficient. These diseases can be treated with immune-modulating therapy. The ACES Study will focus on determining the frequencies of known antibodies and finding new, currently unknown, antibodies, causing epilepsy. Therefore patients will be investigated with epilepsy of unknown origin. To find new antibodies sera of patients with epilepsy will be added to brain sections of rats and to cultivated neuronal cells to look for a reaction. If new antibodies will be detected clinical features will be mapped of the patients. Also effects of antibodies on brain cells will be determined. Discovery of new antibodies can provide new treatment options for these patients. Also it will enable to discover more about the pathologic mechanisms of epilepsy.

Eligibility Criteria:
Inclusion Criteria:

* Age of 18 and older.
* Status epilepticus or new onset seizures with signs of limbic encephalitis (clinical picture, MRI (FLAIR abnormalities), EEG abnormalities or CSF findings (CSF pleocytosis, increased IgG index, oligoclonal bands), or:
* Patients with acquired chronic focal epilepsy with an unknown cause.

Exclusion Criteria:

* Children
* Epilepsy with known cause
Effect of Protein Source During Ketogenic Weight Loss Intervention

This randomized, controlled, single-blinded study will investigate how the protein source in a high-protein ketogenic diet affects metabolic weight loss outcomes after a 12-week dietary intervention

This randomized, controlled, single-blinded study will compare how a ketogenic weight loss diet, supplemented with either animal- or plant-based protein affects: (i) metabolic markers (adipokine and cytokine) in adipose tissue and blood, (ii) adipose tissue immune cell profiles, and (iii) adipocyte characteristics and their interaction with other cells (e.g. immune cells and muscle cells). To better determine how tissue characteristics affect the whole body level, the relationships between adipose tissue characteristics and blood lipid and inflammatory markers will also be examined. Participants undergo anthropometric measurements, questionnaires, body composition assessment, energy assessment, blood draws, and adipose tissue biopsies from the abdominal and femoral adipose tissue depots

Eligibility Criteria:
Inclusion Criteria:

* Adults between 18-60 years old
* BMI: \>29.99kg/m2

Exclusion Criteria:

* Any chronic metabolic conditions (e.g. CVD)
* Renal impairment (creatinine clearance \<60 mL/min)
* Uncontrolled hypothyroidism
* Pregnant, breastfeeding, or postmenopausal females
* Past (\<6 year) or present use of nicotine products
* Use of cannabis products
* Use of any other medications that may affect study outcomes (e.g. anti-depressants)
* Participants who have had a number of CT scans in the course of the year
* Participants following a vegan diet
Satisfaction Level of Communication Quality

This study mainly explores the actual situation of AAC users in New Taipei City in their daily life after applying for social security subsidies, and the satisfaction of the main caregivers to AAC actually helping case communication. In summary, the main purposes of this study are as follows:

1. Discuss the communication satisfaction of the main caregivers to AAC users.
2. Explore the barriers to AAC users applying AAC.

This study was based on cross-sectional research, questionnaire survey, and the evaluation of the questionnaires by experts. The research tool part of the research and development reference to the domestic and foreign literature and questionnaires, developed a self-made questionnaire "communication quality satisfaction questionnaire", with continuous use and no continuous use of the auxiliary communication system as the self-variation in the study, in order to separately discuss the main caregiver Communication satisfaction of AAC users in different situations and activities in daily life, as well as obstacles in application

Eligibility Criteria:
Inclusion Criteria:

1. Apply for the communication from the New North City Access Center to identify the primary caregiver of the AAC users who have approved and purchased the AAC users.
2. The primary caregiver has normal communication skills and is interviewed by telephone.

Exclusion Criteria:

who may not participate in this study if you have any of the following conditions:

1. The main caregiver is unable to conduct telephone interviews due to physiological conditions (listening, deaf-mute)
TEAS-induced Analgesia: Dual vs Single Acupoints

The purpose of this study is to evaluate the effects of transcutaneous electric acupoint stimulation(TEAS) at single acupoint or dual acupoints on opioid consumption and postoperative pain in patients undergoing radical mastectomy


Eligibility Criteria:
Inclusion Criteria:

* patients aged from 18 to 65 yrs
* body mass index (BMI) of 18 to 30 kg/m2
* elective radical mastectomy under general anesthesia

Exclusion Criteria:

* contradictions to electric stimulation
* difficulties in communication
* histories of general anesthesia, drug or alcohol abuse or addiction
* cardiac dysfunction or severe hypertension, confirmed hepatic dysfunction and renal impairment
* participants recruited into other clinical trials during last three months
Effectiveness of Eye Mask and Headset in Primary Headache

Primary headache can be triggered by light or noise. Getting rest in a quiet and dark environment for the treatment of acute headache is recommended for relief of pain during an attack. It is hard to provide this kind of environment in a busy emergency department. We aimed to determine if eye masks and noise reduction head sets are effective in reducing pain scores, fastening pain relief when used together with standard care. We also aimed to see if these methods were preferred over standard care.


Eligibility Criteria:
Inclusion Criteria:

* patients with current headache as a chief complaint presenting to Emergency Department
* triage category 3,4,5.
* preliminary clinical diagnosis of primary headache is made after brief history and physical exam by the attending emergency physician according to International Classification of Headache disorders version 3
* the attending physician ordered IV treatment

Exclusion Criteria:

* pregnant
* known or suspected diagnosis of a secondary etiology of headache at presentation or at any point during the Emergency Department visit
* head trauma within 14 days
* inability comply with the study due to insufficient knowledge of Turkish language
* known allergy to standard treatment or rescue treatment
* history of GI bleeding in the last year
* taking any analgesic drug in the last four hours or taking the maximum dose of standard treatment before coming to Emergency Department
* hepatic or renal failure
* patients with hearing or vision loss
Study of Transitioning From Alendronate to Denosumab

The study will evaluate the efficacy and safety of transitioning postmenopausal women on current alendronate therapy to denosumab. Endpoints studied will include bone mineral density, bone turnover markers and bone histology in a subset of subjects.


Eligibility Criteria:
Inclusion Criteria:

* Postmenopausal females 55 yrs or older
* Received alendronate therapy for osteoporosis for at least 6 months prior to entry into study
* Lumbar spine or total hip Bone Mineral Density (BMD) corresponding to T-score ≤ -2 and ≥ -4

Exclusion Criteria:

* Vitamin D deficiency
* Administration of intravenous bisphosphonate, or
* fluoride (except for dental treatment) or
* strontium ranelate
* Administration of Parathyroid Hormone (PTH) or Parathyroid Hormone (PTH) derivatives (eg; teriparatide) within the last year
* Administration of any bisphosphonate other than alendronate (ALN) within 1 year of screening
Arterial Inflow and Muscle Ischemia During Calf Stimulation With the Veinoplus Device

Stimulation of arterial inflow to the lower limb is important to obtain functional improvement in peripheral artery diseased (PAD) patients with claudication. The clinical effect of muscle stimulation to increase arterial inflow and the direct evaluation of the regional blood flow impairment (RBFI) in the area of stimulation, have not been evaluated in PAD patients.

Fifteen adult patients with stable arterial claudication will participate. Recruitment will be performed among patients referred for exercise oxymetry (treadmill: 3.2km.h-1, 10% slope) After two minutes of rest, the gastrocnemius will be stimulated for 20 minutes at an increasing frequency rate with 5 min steps (1 Hz, 1.25 Hz, 1.5 Hz and 1.75 Hz) on the most symptomatic side.

The investigators record the tcpo2 value, arterial blood inflow with ultrasound of the femoral artery, and near infra-red spectrometry (NIRS) on both sides.

Patients will be instructed to report eventual contraction-induced pain in the stimulated calf.

Investigations are conducted in an air-conditioned 22+/-2 °C room, with the patient comfortably seated on an armchair.

Measured ware started at rest and performed throughout the period pf stimulation and for 10 minutes after the end of the stimulation

Muscle stimulation:

We apply a series of 20 minutes of stimulation with the Veinoplus® device. The device delivers a stimulation of incremental rate with 5 minutes intervals, with 1 Hz, 1.25 Hz, 1.5 Hz and 1.75 Hz and then stops automatically.

Ultrasound measurements The Diameter of the superficial femoral artery was measured at rest on both sides before each study. The VTI of 3 cardiac cycles (three peaks systolic velocity) will be measured by duplex ultrasound imaging, to calculate the arterial inflow to the leg. Results will be expressed in l /min.

Tcpo2 recording TcpO2 is measured at the chest and on both calves with TCM 400 (Radiometer, DK). Results are expressed in DROP index(mmHg) values.

Near Infra-red spectroscopy (NIRS) We use the ARTinis NIRS device (ARTinis; NL) to estimate tissue saturation (StO2) on both gastrocnemius muscles of the leg.

Systemic hemodynamic parameters

Systemic and diastolic arterial pressures and heart rate are recorded every two minutes using Dinamap V100 (GE france).

Eligibility Criteria:
Inclusion Criteria:

* French native
* Stable stage 2 peripheral artery disease
* Patent femoral artery on both sides
* Age \> 18 years

Exclusion Criteria:

* Pregnancy
* Adults protected by maw
Comparison Of Outcome Of Wound Closure After Thyroid Surgery With And Without Platysma Suturing

Comparison Of Outcome Of Wound Closure After Thyroid Surgery With And Without Platysma Suturing in terms of wound scar and pain.

This randomized controlled trail was conducted at Surgical Ward from January 2021 to July 2021.

Materials and Methods Total 72 patients (indicated for thyroid surgery) who were fulfilling the inclusion criteria were enrolled. Patients were divided randomly into two groups by using lottery method. In Group A patients wound closure was done without Platysma Suturing and in Group-B patients wound closure was done with Platysma Suturing. Pain assessment was done with the help of VAS after surgery (6, Hours, 24 hours, 48 hours). Scar assessment was carried out with the help of POSAS. All this information was noted by the researcher himself and noted on a well-designed questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* : Both men and women patients in the age range (20-70 years) undergoing primary thyroid surgery were included.

Exclusion Criteria:

* Patients with disorders of wound healing, diabetes mellitus, Pre-operative known malignant condition, history of neck surgery or not willing to participate in the study were excluded.
Assessment of Skeletal Muscle Dysfunction in Patient With Idiopathic Pulmonary Fibrosis

Interstitial lung disease includes a heterogeneous group of chronic lung conditions that is characterized by exertional dyspnoea and poor health related quality of life . includes idiopathic pulmonary fibrosis of unknown cause And another groups are caused by occupational, inorganic or organic exposure, drug- induced toxicities, or are secondaries to connective tissue disease The clinical course and outcome of interstitial lung diseases are highly variable between different sub types, but survival after diagnosis of idiopathic pulmonary fibrosis is only 2.5 to 5 years is a progressive and fibrosing lung disease that is characterized by architectural distortion of the lung parenchyma and is progressive, with a dismal prognosis Also patient with idiopathic pulmonary fibrosis generally demonstrate greater abnormalities of exercise induced gas exchange than those with other forms of Interstitial lung disease

Interstitial lung disease includes a heterogeneous group of chronic lung conditions that is characterized by exertional dyspnoea and poor health related quality of life . includes idiopathic pulmonary fibrosis of unknown cause And another groups are caused by occupational, inorganic or organic exposure, drug- induced toxicities, or are secondaries to connective tissue disease The clinical course and outcome of interstitial lung diseases are highly variable between different sub types, but survival after diagnosis of idiopathic pulmonary fibrosis is only 2.5 to 5 years is a progressive and fibrosing lung disease that is characterized by architectural distortion of the lung parenchyma and is progressive, with a dismal prognosis Also patient with idiopathic pulmonary fibrosis generally demonstrate greater abnormalities of exercise induced gas exchange than those with other forms of Interstitial lung disease People with exhibit limitation in peak exercise capacity, which is associated with impaired ventilation, gas exchange and pulmonary perfusion abnormalities Also in people with interstitial lung diseases there is a relationship between quadriceps muscle weakness and exercise capacity raising the importance of skeletal muscle dysfunction. Furthermore, since interstitial lung diseases is the leading diagnosis referred for lung transplant characterizing skeletal muscle dysfunction and its relationship to exercise capacity prior to lung transplant is of specific interest for this population.

The cause of muscle dysfunction in individuals with lung disease is multifactorial, including factors such as disuse, hypoxaemia, malnutrition, oxidative stress, systemic inflammation and medication Pulmonary inflammation and oxidative stress are thought to be pivotal in the pathogenesis of idiopathic interstitial pneumonia

Eligibility Criteria:
Inclusion Criteria:

* All patient who will be presented to assuit chest department and diagnosed as IPF.

Exclusion Criteria:

* 1-IPF patient with malignant tumors. 2-Comorbid end stage renal, cardiac or hepatic patient. 3-patient who refused to participate in the study
Effects of Inspiratory Muscle Training in COPD

The additional effect of inspiratory muscle training as an adjunct to a general exercise training program in patients with COPD with inspiratory muscle weakness will be studied. The main hypothesis is that inspiratory muscle training combined with an exercise training program improves functional exercise capacity more than an exercise training program without the addition of an inspiratory muscle training program.


Eligibility Criteria:
Inclusion Criteria:

* Patients with COPD
* Eligible to participate in a exercise training intervention of 8 weeks
* Pi,max \<60cmH2O or \<50% of the predicted normal value

Exclusion Criteria:

* Major comorbidities preventing successful participation in an 8 week exercise training intervention