cyrilzakka/clinical-trials huggingface dataset:
Resistance Characteristics and Development of Diagnostic Model for Postoperative UTI in Patients With Kidney Stones

The combined detection of HBP, ADPN, NGAL, and hs-CRP enables the construction of a highly efficient diagnostic model, offering a novel strategy for early infection identification and risk stratification after surgery.

This study investigated pathogen distribution, antimicrobial resistance, and the diagnostic utility of biomarkers (hs-CRP, HBP, NGAL, ADPN) for Urinary Tract Infections (UTI) after kidney stone surgery. A total of 130 patients with kidney stones, treated between February 2021 and December 2024, were included in this study. Based on the occurrence of postoperative UTIs, they were categorized into the UTI group (n=41) and the Non-UTI group (n=89). Laboratory parameters, including WBC, NLR, NEU, hs-CRP, HBP, NGAL, and ADPN levels, were measured. Midstream clean-catch urine samples from patients in the UTI group were collected for pathogen identification and antimicrobial susceptibility testing. Pearson correlation analysis was performed to assess the relationships among these biomarkers, ROC curve analysis was conducted to evaluate diagnostic performance, and logistic regression analysis was used to identify independent risk factors for postoperative infections.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥18 years;
2. Diagnosis of urinary calculi confirmed by CT, X-ray, or ultrasound;
3. Complete clinical data available. -

Exclusion Criteria:

1. Presence of active UTI or other infections prior to surgery;
2. Coexisting urological disorders (e.g., bladder cancer, neurogenic bladder);
3. Prolonged use of immunosuppressants or antibiotics (\>2 weeks). -
Influencer E-Cigarette and Cannabis Marketing: a Survey-Based Experiment Among Adolescents

Adolescent non-users of e-cigarettes and cannabis (N = 1,462) participated in the in-class survey-based experiment. They were randomly shown 3 pairs of images featuring influencers promoting e-cigarettes alongside cannabis, (experimental group), or no-substance use or display (placebo treatment), or e-cigarette promotion alone (control). After viewing each pair of images, participants rated perceptions of influencer credibility (i.e., honesty, trustworthiness, knowledge) on the scale of 0 (e.g., dishonest) to 100 (honest).

Susceptibility to use e-cigarettes was assessed after participants viewed all the images. These outcomes were then compared among participants who perceived influencers as credible and those who perceived influencers as non-credible.

Adolescents (13-17 years of age) living in California were recruited by Tobacco Center of Regulatory Science at the University of Southern California (USC TCORS) to participate in the ADVANCE survey cohort focused on tobacco-related attitudes and behaviors. Participants completed the experiment, which was part of the survey at cohort's Wave 7, on Chromebooks in classroom. All participants provided informed consent and parental assent prior to participating in the experiment. The study was approved by the University of Southern California Institutional Review Board (HS-19-00682-AM016). Respondents were randomly shown 3 pairs of images featuring influencers promoting e-cigarettes (image 1) paired with cannabis (image 2), (experimental group), or no-substance use or display (two images featuring neutral profiles of influencers), (placebo treatment), or e-cigarette promotion (image 1) paired with a neutral profile (with no e-cigarette) of the influencer featured in image 1 (control).

Eligibility Criteria:
Inclusion Criteria:

* English fluency,
* Current California resident.

Exclusion Criteria:

Not meeting these criteria:

* English fluency,
* Current California resident.
The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response

There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain heat stress - "heat intolerance" is also attributed to over-expression of inflammatory cytokines. Acclimation to heat improves human sustainability to heat and is a leading protective factor against heat stroke. The investigators hypothesize that the lower stress encountered during the process of acclimation to heat will be reflected by an over-ride in the expression of anti-inflammatory over the pro-inflammatory cytokines. This, in turn will attenuate the pathological cascade leading to heat stroke.


Eligibility Criteria:
Inclusion Criteria:

* age:18-25
* medically screened (healthy)

Exclusion Criteria:

* BMI over 22 kg/m2
* systolic blood pressure over 120 mmHg
* any febrile illness during the last week preceding the study
* any skin disease
* diabetes
* any heart conditions.
High Flow Nasal Cannula During Pulmonary Rehabilitation

The primary purpose of this study is to compare and assess the immediate and long-term effects on pulmonary rehabilitation training with the usage of HFNC or conventional oxygen therapy device.

The hypotheses was, with high flow nasal cannula usage while exercising, the physiological outcome measurements would be better than conventional oxygen therapy device. Also, the usage of HFNC can immediately increase patient's exercising endurance and decrease dyspnea caused by exercising.

Pulmonary Rehabilitation is one of the most recommended methods to improve the muscle function of COPD patients. By exercise training, even patients with severe COPD can increase muscle strength, improve skeletal muscle function and enhance exercise endurance. Due to improvements in exercise endurance, when exercising at a higher intensity, ventilation support and dynamic hyperinflation would slightly decrease which leads to less dyspnea during exercise. Continuously exercising can also increase the motivation to exercise, reduce mood irritability and psychological burden caused by symptoms. By exercising, patient's health status can be both improved physically and mentally.

High Flow Nasal Cannula (HFNC) is a non-invasive ventilatory device that provides stable oxygen concentration, temperature (37℃) and humidity (Relative Humidity: 100%). Humidity provided by the HFNC reduces irritation caused by the high flow, which leads to the increase of user's tolerance with the device. With the half-closed system formed by a nasal prong, when the high flow enters the upper airway, continue positive airway pressure would be formed.

Subjects enrolled into this study are required to join a 6-week pulmonary rehabilitation program. Before starting the program, subjects were randomly assigned to high flow nasal cannula group and conventional oxygen therapy group. When exercising, the nasal cannula group would receive an oxygen flow of 3 - 5L to maintain SpO2\>90% and the HFNC group with high flow setting of 45-50Lpm along with oxygen flow of 3-5L also to maintain SpO2\>90%. When joining the pulmonary rehabilitation program, patients are required to exercise for approximately 45 minutes per session. When exercising, changes in the degree of dyspnea, quadriceps blood flow and hemodynamics are assessed. After 6-week of the exercise training, all the parameters will again be assessed and compared to the primary data that was collected from the beginning of the program.

Eligibility Criteria:
Inclusion Criteria:

* Age \> 55 years
* COPD patients with confirmed pulmonary function test results of FEV1\<70%
* Regular follow-up at the pulmonary medicine clinic
* Stable condition without acute exacerbation
* No pulmonary rehabilitation training within a year
* None oxygen usage at home
* No smoking history or quit smoking
* Inform consent signed

Exclusion Criteria:

* Fever (Body Temperature \>37.5°C)
* Acute infection symptoms
* Unstable cardiovascular status (Eg: Blood pressure \>150/100 mmHg after medication usage, angina pectoris, or abnormal ECG)
* Activity restrictions due to orthopedic or neuromuscular disease
Spectral Analysis of Bowel Sounds in Preterm Babies of Less Than 32 Weeks of Amenorrhea (WA) as Predictive Factor of Enterocolitis

The recording or bowels is easy and cheap. The investigators wonder if these sounds are modified in babies with high risk of necrotizing enterocolitis. In this study, the investigators suggest to record and do a spectral analysis of 30 seconds of bowel sounds in preterm babies of less than 32WA before and after enteral nutrition, every day until the end of hospitalization. A spectral analysis will be made for each record to determine frequencies of the signal. The investigators will try to determine physiological frequencies and look for modifications in pathological situations.


Eligibility Criteria:
Inclusion Criteria:

* preterm babies of less than 32WA

Exclusion Criteria:

* preterm babies of more than 32WA,
* digestive congenital malformation
Evaluation of DeltaMaxx® Microcoil System in Intracranial Aneurysms

The primary objective of this registry is to assess the safety and angiographic outcomes of endovascular treatment of intracranial aneurysms using the DeltaMaxx Microcoil System.


Eligibility Criteria:
Inclusion Criteria:

* Subject age ≥18 and ≤80 with a diagnosis of ruptured or unruptured intracranial aneurysm judged suitable for selective endovascular treatment by coil occlusion during single procedure
* Investigator intends to use DeltaMaxx Microcoil system during coiling procedure
* Investigator intends to use only Codman Neuro microcoils during coiling procedure
* Aneurysm size \[largest measurement from the cross sectional images to determine overall aneurysm size, not just the lumen\] ≥6 mm
* If ruptured aneurysm: Hunt and Hess 1, 2, or 3
* If unruptured aneurysm: Subject grade Modified Rankin Scale 0 - 2
* The subject or his/her Legally Authorized Representative must voluntarily provide Informed Consent for participation in this study and agree to return for all study visits.

Exclusion Criteria:

* Prior treatment (surgical or endovascular) of the target aneurysm
* Subjects with more than one aneurysm (\>2 mm) that have been treated with endovascular or clipping techniques in the past 30 days.
* Subject with social, medical or psychological conditions that interfere with treatment and follow-up evaluation
* Women who are pregnant or plan to become pregnant during the study
* Life expectancy less than 12 months.
* Presence of arteriovenous malformation
* Fusiform, mycotic, traumatic, or tumoral aneurysms
* Planned aneurysm treatment by parent vessel occlusion
* Subject enrolled in any concurrent study
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation

The worldwide prevalence of chronic constipation (CC) is 15%, and women are more likely to develop the disease than men. CC have a significant impact on quality of life and increase the burden of national health insurance. The conventional medication treatments are primarily symptom-specific and have limited efficacy. Previous small sample study had shown the therapeutic potential of transcutaneous auricular vagus nerve stimulation (taVNS) for irritable bowel syndrome with constipation (IBS-C). The aim of this study was to investigate whether taVNS could improve defecation condition and constipation symptoms in patients with CC.


Eligibility Criteria:
Inclusion Criteria:

1. FC or IBS-C patients aged 18-75 years who meet the diagnostic criteria for Rome IV;
2. Complete spontaneous bowel movements (CSBMs) per week \< 3;
3. No constipation medication used for at least 2 weeks prior to enrollment, not participated in clinical trials in the past three months, and no abnormal colonoscopy within the past 12 months in those with alarm symptoms.

Exclusion Criteria:

1. Have cognitive impairment, psychiatric disorders, or conditions that may affect patient cooperation;
2. Have a cardiac pacemaker implantation or other electronically implanted devices;
3. Prior taVNS treatment;
4. History of colorectal surgery, except for simple appendectomy;
5. Severe cardiovascular, hepatic, or renal disease;
6. Known malignancy;
7. Secondary constipation caused by medications and other diseases;
8. Pregnant or lactating women;
9. Refusal to sign an informed consent.
Effects of Eldoa Versus Meckenzie Exercise on Non-specific Low Back Pain Patients

To determine the effects of Eldoa and Mckenzie exercises in posture. To determine the effects of Eldoa and Mckenzie exercises in ROM.

To determine the effects of Eldoa and Mckenzie exercises in pain. To determine the effects of Eldoa and Mckenzie exercises in Quality of life.

Eligibility Criteria:
Inclusion Criteria:

* Gender (Female)
* Age (40-69)
* NPRS (Grade \<3)
* Chronic pain (more than or equal to 3 months)
* Restricted ROM
* Lumbar straightening

Exclusion Criteria:

* Any other orthopedic or neurological condition of hip or lumbar spine.
* sign and symptoms of lower motor neuron disease.
* Current use of medication prescribed for pain.
* Radiculopathy.
* malignancy.
* Fracture.
* Lumbar trauma.
* Disc pathology
Reduction of the Metabolic Syndrome in Navarra-Spain

The purpose of this study is to determine whether a dietary pattern based on crononutrition and dietary training, together with dietary and psychological control, can reduce the body weight, improve the oxidative and inflammatory state in subjects with diagnosed metabolic syndrome features and can reduce the prevalence of the Metabolic syndrome in the population.

The dietary pattern that characterizes the present nutritional intervention study is based on personalized diet, by elaborating tailoring-diets for each subject regarding his energetic needs and assuring a high adherence to the Mediterranean Diet. Moreover, the diet to be performed will be a hyperproteic diet to guarantee a satiety effect and a lower recovery of the lost weight, in accordance with the results derived from the main European study about nutrition (DIOGENES). The glycemic index/load will be also controlled in the study diet. The increase of the antioxidant capacity of the diet will be increased by the intake of fruits, walnuts and virgin olive oil among other antioxidant containing foods.

The present initiative, based on the traditional diet, aims to integrate the main results obtained from diverse observational epidemiological studies and interventional studies in the dietary pattern of the present study. At the same time, the study will apply the concept of crononutrition by selecting and distributing the foods thorough the day according the physiological needs of each individual.

In addition to the quantitative and qualitative composition of the diet, the study will take into account other important factors such as the behavior habits regarding the food, the frequency of consumption, the size of the eating portions, the distribution of the portions along the day, the feeling of fullness, the eating speed and so on. The aforementioned factors have recently been shown to be related to the gain of weight.

Other non dietary factors, such as smoking habits, sedentary life, socio-economic level, will be also controlled in the present study. Moreover, the project will integrate the dietary support together with psychological support due to the fact that the state of mind has been shown to be associated with the MS in some scientific publications.

Eligibility Criteria:
Inclusion Criteria:

* 35-70 years old
* Both sexes: Male and Female
* Metabolic Syndrome according to the IDF(2005)criteria:

Waist circumference cutoffs (male ≥94 cm or female ≥80 cm) plus any two of the following four factors:

1. Fasting glucose ≥5.55 mmol/L or use of antidiabetic medication
2. Systolic BP ≥130 mm Hg, diastolic BP ≥85 mm Hg, or use of antihypertensive medication
3. Fasting triglycerides ≥1.7 mm/L; and HDL-C \<1.0 mm/L in men and \<1.3 mm/L in women or specific treatment for this lipid abnormality

Exclusion Criteria:

* Recent follow-up of diets designed for weight loss
* Unstable weight in the past 3 months
* Alcoholic and drug dependence
* Hormonal treatment
* No stable pharmacological treatment
* Eating-disordered behaviors
* Severe physical or mental disability
* Pregnancy
* Terminal disease
* Institutionalization
An Implantable Microstimulator for the Chronic Treatment of Urinary Urgency-Frequency Syndrome

The goal of this study is to investigate the safety and effectiveness of a new implanted device designed to treat Urinary Urgency-Frequency Syndrome.


Eligibility Criteria:
Key Inclusion criteria:

* Age 18 years and above.
* Diagnosed with urinary urgency-frequency syndrome.
* Have no reported history of urethral obstruction/stricture, bladder calculi or bladder tumor.
* Have normal upper urinary tract function.
* Be capable of giving informed consent.
* Be capable and willing to follow all study related procedures.

Key Exclusion Criteria:

* Have any active implantable device regardless of whether stimulation status is ON or OFF.
* Are pregnant as confirmed by a urine pregnancy test or plan to become pregnant during the following 12 month period.
* Less than one year post partum and/or are breast-feeding.
* Have any large passive implant that contains metal located within 30 cm of the chair pad while seated (e.g., hip replacement).
* Have conditions requiring magnetic resonance imaging (MRI) evaluation.
* Have conditions requiring diathermy procedures.
* Have an inability to operate the bion Remote Control and bion Recharging System either by self or caregiver.
* Have diabetes with peripheral nerve involvement or have severe uncontrolled diabetes.
* Have history of coagulopathy or bleeding disorder.
* Have pelvic pain in the absence of voiding dysfunction.
* Have anatomical restrictions such that the study device placement is not possible.
* Are currently participating or have participated within the past 30 days in any clinical investigation involving or impacting urinary or renal function.
* Cannot independently comprehend and complete the questionnaires.
How to Reduce Unnecessary Blood Cultures: Construction and Validation of a Predictive Score for Blood Culture Positivity in Intensive Care

Prospective observational cohort consisting of all adult patients admitted to participating critical care units (ICU and CCU) during the study period, with blood cultures collected as part of their care, and who did not express any objection to participating.

For each patient, data will be collected prospectively for each blood culture set collected.


Eligibility Criteria:
Inclusion Criteria:

* Male or female, age 18 years or older
* Patient admitted to an ICU or ICU
* patient with a blood culture sample as part of care

Exclusion Criteria:

* Patient already included in this study during a previous hospitalisation
* Opposition expressed for participation in the study
The Predictive Performance of Renal Ultrasound on Changes in Renal Clearance

The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in glomerular filtration rate (GFR) in response to fluid loading, from those for whom fluid loading is without benefit of directly harmful.

The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in GFR in response to fluid loading, from those for whom fluid loading is without benefit of directly harmful.

Patients available for inclusion will receive a baseline administration of Tc-99-DTPA for precise determination of GFR/renal function by blood and urine samples.

Baseline values of ultrasound measures will be obtained, including renal arterial, renal venous, portal venous and hepatic venous Doppler measures and renal contrast enhanced ultrasound (CEUS) will also be recorded.

After two hours, baseline values of GFR are finished. The patient is then exposed to passive leg raising and ultrasound measures are repeated, including renal arterial, renal venous, portal venous and hepatic venous Doppler measures.

The participant then receives a standardised fluid bolus of 7 ml/kg (ideal body weight) Once the fluid bolus administration is complete, renal ultrasound is repeated, including renal arterial, renal venous, portal venous, hepatic venous Doppler measures and renal CEUS.

Follow-up determination of GFR/renal function based on Tc-99-DTPA after fluid therapy is repeated with blood and urine samples.

Eligibility Criteria:
Inclusion Criteria:

* Patients ≥ 18 years admitted to the ICU, Aarhus University Hospital.
* Patients who are assessed by their attending physician as having need for fluid therapy.

Exclusion Criteria:

* Insufficient ultrasound imaging of the kidneys.
* Pregnancy.
* Intolerance to any ultrasound contrast agent or isotopes, including intolerance for human albumin.
* Prior enrolment in a conflicting research study.
* Known morphological kidney disease.
* Need for dialysis.
* Need for extracorporeal membrane oxygenation (ECMO).
* Prior participation.
* Severe pulmonary hypertension (systolic pulmonary pressure \> 90 mmHg)
68Ga-NOTA-PRGD2 PET/CT in Patients With Lung Injury and Pulmonary Fibrosis

This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-PRGD2 in lung injury (LI) and pulmonary fibrosis (PF) patients. A single dose of nearly 111 MBq 68Ga-NOTA-PRGD2 (≤ 40 µg NOTA-PRGD2) will be intravenously injected into patients with LI/PF. Visual and semiquantitative method will be used to assess the PET/CT images.

The αvβ3-integrin is a transmembrane heterodimeric receptor that mediates cell-cell and cell-extracellular matrix adhesion. The αvβ3-integrin plays a pivotal role in promoting and sustaining angiogenesis and fibrosis. Cyclic arginine-glycine-aspartic acid (RGD) peptide is the key integrin recognition motif that can strongly bind to the αvβ3-integrin, which makes the RGD-based peptides hold a promise for imaging and treatment of diseases characterised with angiogenesis and fibrosis including LI and PF.

Animal study in bleomycin induced lung fibrosis showed good uptake ratio of 68Ga-NOTA-PRGD2 in lung vs background. For interests in clinical translation of 68Ga-NOTA-PRGD2, an open-label dynamic whole-body PET/CT study was designed to investigate safety and diagnostic performance of 68Ga-NOTA-PRGD2 in patients with LI or PF.

Eligibility Criteria:
Inclusion Criteria:

Patients with idiopathic pulmonary fibrosis

* Males and females, ≥18 years old.
* Characteristic clinical signs, symptoms and laboratory tests suggesting the diagnosis of LI/PF.
* The diagnosis of IPF is based on The Centres for Disease Control and Prevention (CDC) criteria for diagnosing LI/PF. They rely on a combination of clinical, radiological, operative and histological findings, in addition to results of other laboratory tests.

Exclusion Criteria:

* Females planning to bear a child recently or with childbearing potential.
* Renal function: serum creatinine \>3.0 mg/dL (270 μM/L).
* Liver function: any hepatic enzyme level more than 5 times upper limit of normal.
* Known severe allergy or hypersensitivity to IV radiographic contrast.
* Patients not able to enter the bore of the PET/CT scanner.
* Inability to lie still for the entire imaging time because of cough, pain, etc.
* Inability to complete the needed examinations due to severe claustrophobia, radiation phobia, etc.
* Concurrent severe and/or uncontrolled and/or unstable other medical disease that, in the opinion of the investigator, may significantly interfere with study compliance.