cyrilzakka/clinical-trials huggingface dataset:
Surgical Hand Washing and Sterile Dressing Training With Virtual Reality Glasses

ABSTRACT This study is a comparison of the impact of virtual reality on surgical handwashing and sterile dressing knowledge, skills, satisfaction, and confidence in nursing students enrolled in surgical nursing, as opposed to conventional teaching methods.

Keywords: Virtual reality, surgical nursing education, surgical handwashing and sterile dressing skills, scenario-based education, three-dimensional video education.

This research is a randomized controlled experimental study aiming to investigate the impact of scenario-based three-dimensional video education using virtual reality goggles on surgical handwashing and sterile dressing skills. Volunteer nursing students, forming the research sample, were divided into three groups using a simple random sampling method. The first group was provided with an 11-minute VR experience using virtual reality goggles, repeated three times. The second group received theoretical training methods, with a one-time 30-minute session and a demonstration, followed by free study time. The third group received training three times with an 11-minute video. Three weeks later, the students' skills were assessed using a validated skills assessment form. Their confidence and satisfaction levels were evaluated through a questionnaire.

Eligibility Criteria:
Inclusion Criteria:

To be 18 years and older,

Being an active student of the Nursing Department,

Being enrolled in the Surgical Nursing Diseases Course for the first time,

Not having claustrophobia,

Not having head or neck disorders that would prevent wearing virtual reality goggles.

Exclusion Criteria:

Being a graduate of a Health Vocational High School,

Being a graduate of a pre-license health services vocational college,

Having attended any webinar, congress, or meeting related to surgical hand washing and sterile dressing,

Having professional working experience in the nursing/healthcare field.
Synovial Chondrosarcoma: a Single Institution Experience

single institution cases series review of histological, radiological and clinical data

single institution cases series review of histological, radiological and clinical data. Investigators will retrieve from the archives of the Rizzoli institute all the cases with a histological diagnosis of synovial chondrosarcoma.

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients treated at Rizzoli Institute from 01 January 1982 to 31 December 2017
* Diagnosis of synovial chondrosarcoma
* Age ≥ 18 years
* Histological slides / formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis
* Written informed consent prior to any study-specific analysis and/or data collection

Exclusion Criteria:

* Patients with histological diagnosis different from synovial chondrosarcoma
Race, Ethnicity, and Diffuse Parenchymal Lung Disease

The purpose of this study is to identify factors that contribute to higher mortality rates among blacks and Hispanics with diffuse parenchymal lung disease.

It is well known that both socioeconomic and biological factors may contribute to race- and ethnicity-based health disparities. Black and Hispanic Americans have worse access to healthcare services and tend to receive care from physicians who cannot themselves access the same services for their patients that physicians who care for white patients can. These factors may play important roles in the development and maintenance of health disparities. In addition, biological differences may contribute to disparities. We propose to identify factors that explain survival disparities in a group of lung diseases called diffuse parenchymal lung diseases (DPLDs), including a severe form of DPLD called idiopathic pulmonary fibrosis (IPF). We will follow patients with DPLD at our center and measure both social and biological factors to try to identify the factors that lead to survival disparities between races. Results of this study will be used to design clinical trials aimed at reducing these disparities.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of IPF or other DPLD according to ATS criteria
* Signed informed consent

Exclusion Criteria:

* None
PENK Methylation Test for Detecting Bladder Cancer

The primary objective of this clinical trial is to determine the sensitivity and specificity of the EarlyTect® Bladder Cancer test for bladder cancer among patients with hematuria by comparing it to the results of cystoscopy examinations.

The second objective is to compare the clinical performance of EarlyTect® Bladder Cancer test with a NMP22 test and urine cytology test with respect to bladder cancer. By histopathological examination, lesions identified during cystoscopy will be confirmed as malignant or non-malignant by histological examination.

Patients with hematuria who are scheduled for cystoscopy will be asked to collect a urine sample for EarlyTect® Bladder Cancer test and will undergo NMP22 and urine cytology tests. The participants will undergo a cystoscopy within 30 days of enrollment. For confirmation of the diagnosis and stage of the tumor, representative histopathology slides from TURBT (Transurethral Resection of Bladder Tumors) may be retrieved and examined by the central pathology laboratory.

Eligibility Criteria:
Inclusion Criteria:

* Individuals who agree to voluntarily sign an informed consent prior to the initiation of screening
* Adults aged ≥40
* Subjects who have had gross or microscopic hematuria within the 3 months
* Subjects who had no history of bladder cancer and upper tract urothelial cancer
* Subjects who will undergo cystoscopy, NMP22 test, and urine cytology within 1 month after consent

Exclusion Criteria:

* Individuals who do not agree to voluntarily sign an informed consent prior to the initiation of screening
* Subjects aged \<40 years
* Subjects with a history of bladder cancer and upper tract urothelial cancer
* Female who are currently menstruating or who have had their last menstrual period within the last 3 days
* Subjects who have undergone invasive procedures in the urinary tract system within the last 3 months
* Subjects with suspected upper urothelial cancer lesions on ultrasound or CT scan
* Subjects who have previously received pelvic radiation therapy
* Subjects who have been diagnosed with other cancers and have received or are currently receiving chemotherapy or immunotherapy within 6 months
* Subjects who require treatment for an active urinary tract infection or vaginitis
* Subjects undergoing prostate cancer treatment or requiring a prostate biopsy
* Subject has any condition which, in the opinion of the investigator should preclude participation in the study
Explore the Clinical Value of 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT in Neuroendocrine Neoplasms

68Ga-DOTANOC and 18F-FDG PET/CT have important values in the staging and clinical treatment of neuroendocrine tumors. Retrospective studies suggest that the positivite rates and SUVmax of dual imaging associated with pathological findings and prognosis. The study was designed to confirm thet clinical values of dual imagings for neuroendocrine tumors.


Eligibility Criteria:
Inclusion Criteria:

1. sign written informed consent form
2. age ≥ 18 years
3. pathologically confirmed neuroendocrine, Ki67\>=10%;
4. ECOG 0-1;
5. No prior antitumor treatment with chemotherapy targeting regimens for neuroendocrine carcimomas, no more than 2 systematic treatment for neuroendocrine tumors;
6. Unresectable disease;
7. At least 1 measurable lesion (only 1 measurable lymph node lesion is excluded) (routine CT scan \>=20mm, spiral CT scan \>=10mm, no prior radiation to measurable lesions);
8. Predicted survival \>=3 months;
9. Negative serum or urine pregnant test within 7 days prior to randomization for child-bearing age women;
10. Sexually active males or females willing to practice contraception during the study until 30 days after end of study.

Exclusion Criteria:

1. In the process of antitumor therapy with effective response;
2. Refuse to accept PET/CT;
3. Pregnant or nursing, or sexually active males or females refuse to practice contraception during the study until 30 days after end of study;
4. Person with no capacity (legally) or inappropriate to continue study treatment for ethics/medical reasons；
PCOS, Therapy and Markers of Cardiovascular Risk

In addition to chronic anovulation and hyperandrogenemia, polycystic ovary syndrome (PCOS) is also characterized by peripheral insulin resistance and hyperinsulinaemia, which in turn lead to the development of diabetes, hypertension, atherosclerosis and coronary heart disease. Serum markers of inflammation are being increasingly recognized as predictors of atherosclerosis and cardiovascular risk, and chronic low-grade inflammation has been recently proposed to play a role in the pathogenesis of metabolic syndrome and type 2 diabetes mellitus. Therefore, the aim of the present study is to evaluate the effects of commonly used non-pharmacologic (diet and lifestyle change) and pharmacologic (oral contraceptives, metformin, anti-androgens) treatment strategies on classical and surrogate cardiovascular risk markers in women with PCOS. The study hypothesis is that some of the commonly used therapies of women with PCOS may have more favorable effects on classical and surrogate markers of cardiovascular risk then others or some of them may even confer a higher risk of cardiovascular events


Eligibility Criteria:
Inclusion Criteria:

* PCOS

Exclusion Criteria:

* diabetes
* pregnancy
* contraindications to oral contraceptives
Maternal and Infant Vitamin Status During the First Nine Months of Infant Life

In this study the investigators wanted to assess vitamin D status and possible consequences of low plasma 25-hydroxyvitamin D levels in a population of healthy mothers and their infants, in the community of Aarhus, Denmark.

Danish people living at northern latitudes (56°N), often with overcast and foggy weather and few sunshine hours are at increased risk of vitamin D insufficiency. Although vitamin D is obtainable from fortified food and oily fish, the major source is the dermal synthesis of the vitamin D through exposure to solar ultraviolet light.

In the 19th century rickets was endemic in northern Europe, and many children developed rickets, a severe bone-deforming disease. Encouragement of sensible sun exposure, supplementation with cod liver oil and fortification of milk with vitamin D, resulted in an almost complete eradication of rickets by the end of the 19th century. At present vitamin D deficiency seems again to be more widespread. The classical outcomes of severe vitamin D deficiency are rickets in growing individuals and osteomalacia in adults. Low vitamin D status also relates to low bone density and increased risk of osteoporotic fractures. Although the incidence of rickets has declined over the last decades, cases attributable to inadequate vitamin D intake and low exposure to sunlight continue to be reported, and maternal vitamin D status may have permanent effects on newborns' health. Pregnant women, newborns, breastfed children, and lactating women are at a high risk of vitamin D deficiency, especially during winter and early spring.

Since fetal plasma 25-hydroxyvitamin D (25OHD) depends on maternal 25OHD, fetal vitamin D status may show seasonal changes parallel to those observed in the mothers. To prevent rickets and vitamin D deficiency in infants, most Western countries, including Denmark, recommend a daily maternal intake during pregnancy and lactation of 10 μg and that breastfed children are given a supplement of 10 μg of vitamin D/day. Despite these recommendations, approximately one third of Danish pregnant and lactating women have vitamin D insufficiency. However, childhood rickets is nowadays rare in Denmark, although it still exists especially among immigrants and mothers with prolonged lactation. Accordingly, in 2010, the Danish National Board of Health extended the recommendations for vitamin D supplementation to the first two years of life.

Eligibility Criteria:
Inclusion Criteria:

* Healthy pregnant Caucasian women aged 24-41 years,
* A normal pregnancy giving birth between 38-42 gestational weeks.

Exclusion Criteria:

* Chronic diseases,
* Other ethnic origin than Caucasian, and
* Alcohol or drug abuse.
Pentacam Study of the Cornea in RA Patients

To evaluate the effect of rheumatoid arthritis (RA) activity on the corneal densitometry, corneal curvature (CC), central corneal thickness (CCT), and lens densitometry by Pentacam and compared these parameters with those of age-matched healthy control subjects

Case - control observational study on RA patients which divided into 2 groups, each group 120 eyes of 60 patients, group 1 of RA in the remission state and group 2 of RA in the active state. Group 3 of 120 eyes of healthy controls. Pentacam was used to measure corneal densitometry, CC, CCT, and lens densitometry. The cornea was divided into 4 concentric zones (0-2, 2-6, 6-10, and 10-12) and anterior, central, and posterior layers according to the depth

Eligibility Criteria:
Inclusion Criteria:

* The included patients had aged more than 20 years with RA only without ocular manifestations with clinically clear cornea with normal anterior and posterior segment examinations with normal intraocular pressure (IOP)

Exclusion Criteria:

* We excluded patients with ocular problems as corneal opacity, cataract, glaucoma, errors of refraction, topical application of eye drops except for topical artificial tears. The presence of systemic diseases other than RA as DM, hypertension were also excluded
Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome

Primary Objectives: To evaluate the effectiveness in the obesity hypoventilation syndrome (OHS) treatment with non-invasive ventilation (NIV) set manually by polysomnography compared to the same treatment with a respirator with automatic NIV adjustment, analyzing as primary variable PaCO2 and as operational variables dropout rate for medical reasons and mortality. Secondary objectives: cost-effectiveness, clinical and functional improvement in wakefulness and during sleep, quality of life, blood pressure monitoring for 24 hours, incidence and evolution of cardiovascular events and use of health resources. Other objectives: 1) effectiveness of treatments in the following subgroups of patients: gender, age, socioeconomic status, severity of sleep apnea, VNI compliance, quality of life and comorbidities; 2) To evaluate the profile of patients with poor adherence to NIV based on clinical severity, gender, age and socioeconomic status in the whole sample and in both intervention groups.

Method: Prospective, blind researchers, randomized, controlled non-inferiority and cost-effectiveness relationship, with two parallel open groups. 200 OHS patients will be divided into two groups by simple randomization 1:1 and followed for one year. The premise of non-inferiority is -2 at the lower limit of the confidence interval 95% for the change in PCO2 between the arms being assessed by analysis of covariance, adjusted for 2-sided, age, sex, body mass index in intention-to-treat and per-protocol analysis. The cost-effectiveness will be performed by Bayesian techniques with sensitivity analysis.

Eligibility Criteria:
Inclusion Criteria:

1. Obesity Hypoventilation Syndrome defined by obesity (IMC≥30) and Hypercapnic respiratory failure (PCO 2\> 45 mm Hg) in stable phase (PH≥7.35 without clinical signs of worsening in at least one previous month).
2. Age between 18-80 years.
3. Absence of other diseases causing hypercapnia as moderate or severe chronic obstructive pulmonary disease (FEV1\> 70% predicted if FEV1 / FVC \<70), neuromuscular, thoracic wall or metabolic disease; d) Absence of narcolepsy or restless legs syndrome.
4. Overcome correctly a 30 minutes test of treatment with VNI in wakefulness.

Exclusion Criteria:

1. Psychophysical disability for questionnaires.
2. Patients who cannot be evaluated by quality of life questionnaires because they present debilitating chronic disease.
3. Chronic nasal obstruction that prevents the use of NIV.
4. Pregnancy.
5. No informed consent obtained.
Weight Watchers and Families

Research suggests that when one spouse loses weight, the other spouse does too. This study will examine whether a ripple effect is observed in untreated spouses and children of individuals participating in a nationally available weight loss program. Participants will be randomly assigned to either receive Weight Watchers immediately or at the end of a 6-month waiting period. Participants and untreated spouses (and any children in the home) will be assessed at baseline, 3, and 6 months.


Eligibility Criteria:
Inclusion Criteria:

* body mass index between 27.0-40.0 kg/m2
* married or living with a significant other who had a BMI \> 25 kg/m2

Exclusion Criteria:

* currently in a weight loss program, dieting, or taking medications that might affect weight
* had participated in a weight loss program in the past year
* lost \> 5% of their body weight in the past 6 months
* were planning to or had undergone weight loss surgery
* had any orthopedic limitations or contraindications to physical activity
* were pregnant, lactating, or less than 6 months postpartum, or were planning to become pregnant in the next year
* reported uncontrolled hypertension, history of coronary heart disease, stroke, or peripheral arterial disease; reported chronic gastrointestinal disease
* endorsed having hepatitis B or C, cirrhosis, or HIV
* had a history of cancer within the past 5 years
* reported a significant psychiatric illness that might interfere with completion of the study.
Optimizing Body Composition & Health After Breast Cancer

The purpose of this study is to conduct a 12-month randomized controlled trial comparing the effects of strength training exercise to stretching and relaxation exercise (control) on body composition (bone, muscle and fat mass), energy balance, bone turnover, and physical function (strength, power, gait, balance and self-report physical function and symptoms) in women who experienced premature menopause from chemotherapy for breast cancer.

As a result of treatment, breast cancer survivors typically experience unhealthy changes in body composition (bone, muscle and fat). Treatments disrupt normal bone and energy balance resulting in bone and muscle wasting and fat gain. Premenopausal women are at greatest risk for these declines because most are thrust into early menopause from chemotherapy. Hormone manipulation therapy (i.e., tamoxifen or arimidex) may further affect these tissues. Exercise can prevent bone and muscle loss and promote fat loss. However, the ability of exercise to reverse unfavorable changes in all components of body composition in women experiencing early menopause from breast cancer treatment has not been specifically studied.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed breast cancer stage I-IIIa
* Completion of a chemotherapy regimen within the previous 5 years
* Premenopausal status (9-12 menstrual cycles/year) at the initiation of chemotherapy
* Complete absence of menstrual cycles for at least 6 months and within one year after starting chemotherapy OR confirmed menopause by blood tests conducted in the last 12 months prior to enrollment.

Exclusion Criteria:

* Presence of any known metastases
* Clinically defined osteoporosis
* Current or previous use of medications known to affect bone metabolism
* Current regular participation (\>2x/wk for at least 30 min/session) in planned impact activities (i.e., volleyball, basketball), or resistance training
* A medical condition, disorder, or medication that contraindicates participation in moderate intensity impact or resistance exercise
The Effects of Integrated Face-to-face Rehabilitation and Telerehabilitation on the Well-being of Family Caregivers

This controlled, non-randomized study (n=180) explores how participating in rehabilitation services for family caregivers affects the caregivers' mood, perceived quality of life, perceived burden of family care, and overall health. Rehabilitation services for family caregivers funded by the Social Insurance Institution of Finland (Kela) include two 5-day periods of face-to-face rehabilitation and a 12-week telerehabilitation period, which is based on The Own Path internet intervention and takes place between the face-to-face rehabilitation periods. The observed changes are compared to participating in two other services: 1) Social Holidays for family caregivers and 2) Kela's rehabilitation services for family caregivers and the family members they are caring for (care recipients).


Eligibility Criteria:
Inclusion Criteria:

* family caregiver
* being 18 years of age or older
* providing daily care for an adult family member
* participating in one of following:

  1. the Kela's integrated face-to-face rehabilitation and telerehabilitation service for family caregivers,
  2. the MTLH's face-to-face Social Holidays for family caregivers or
  3. the Kela's face-to-face rehabilitation services for family caregivers and care recipients
* willingness to participate in the study
Measuring Ethnic Disparities in Family Planning Services in Peru

This study is designed as a crossover randomized controlled trial, to investigate the effects of client's ethnic characteristics on the quality of family planning services.

The study aims at evaluating, in a causal way, whether health providers in Peru might be contributing to ethnic health disparities in the provision of family planning services. We perform a field experiment that combines audit studies and simulated patient methodologies. The study population consists of clinics in Metropolitan Lima that are administered by the Ministry of Health and which provide family planning counseling services. The sample in our study includes 351 clinics. The primary outcome measured in the study was a composite of service provider compliance to guideline technical tasks in family planning counseling. We pre-defined indigenous and mestizo profiles using distinctive cultural attributes such as clothing, styling of hair, posture and patterns of speech. With a 1:1 allocation as per a computer generated randomization schedule, and using permuted blocks of four, clinics were assigned to a sequence of ethnic profiles, either to receive the indigenous then the mestizo profile (sequence 1) or mestizo and then the indigenous profile (sequence 2) in two periods. The trial comprises two treatment periods each of five week's duration. The second treatment period followed the same sequence of visits than the first one to obtain at least a five-week 'wash-out' period to mask the study.

Eligibility Criteria:
Inclusion Criteria:

* Clinic operated by the Ministry of Health
* Clinic must provide family planning services

Exclusion Criteria:

* Primary health clinics with the lowest degree of specialization (categorized as I-1) and thus lacking the number of patients required to enable the simulated patient to pass through the facilities undetected.
Impact of Non-Commercialism Policy in Seattle Schools

This is a 3-year pilot study funded by National Institute of Health will assess and evaluate obesity-related health outcomes of a real-life policy decision, recently voted on and adopted by the Seattle School Board.


Eligibility Criteria:
Inclusion: All students who attend Cleveland and Rainier Beach high schools are eligible.

Exclusion: Those who are no longer attending those schools.