cyrilzakka/clinical-trials huggingface dataset:
A Study on the Effectiveness of WeChat-based Online Education to Reduce Perioperative Anxiety in Breast Cancer Patients

Patients who meet the enrollment criteria will be randomly assigned to the WeChat education group and the regular group. In addition to the regular preoperative visits, the WeChat education group will also watch science videos through WeChat before the surgical procedures. The regular group only received regular preoperative visits and education by ward nurses. The main observation indicator is the incidence of preoperative anxiety defined as the scores of State Anxiety Inventory more than 40 points.

Patients who meet the inclusion criteria will be randomly assigned to the WeChat online education group or the regular group. Two researchers will conduct preoperative education, preoperative evaluation and postoperative follow-up respectively.The patients in WeChat group will be first assessed by a researcher on admission about anxiety and sleep (base on the State-Trait Anxiety Inventory (STAI) scale and the sleep quality scale (SQS)). Once the assessment completed, the patients are required to follow the WeChat public platform to watch the education videos when they are free. The content of the videos is jointly decided by the breast surgeon, anesthetists, and ward nurse including the overall prognosis, surgical approach, postoperative rehabilitation exercises, preparation for anesthesia, anesthesia approach and possible effects of anesthesia, which covers all aspects of surgery, anesthesia, and perioperative care. The videos are presented in an easy-to-understand pattern to ensure participants of all ages and levels of education comfortably understand the content. Participants can simply click on the video dialogue box in the public platform for playback and watch it unconditionally.Patients in regular group will be also assessed by the same researcher on admission for anxiety and sleep (base on State-Trait Anxiety Inventory (STAI) scale; sleep quality scale (SQS) scale). Upon completion of the assessment, they received oral instruction from the ward nurse covering the same contents as above instead of the education video.

Eligibility Criteria:
Inclusion Criteria:

* female patients scheduled for elective breast cancer resection;
* aged 18 to 80 years,;
* American Society of Anesthesiologists (ASA) physical status I-III.

Exclusion Criteria:

* patients diagnosed with primary breast cancer combined with malignant tumors of other organs (such as lung, kidney, intestine, etc.);
* patients with tumor recurrence after reoperation;
* patients failing to cooperate with the study for any reason, such as communication disorders.
Use of Infrared Spectroscopy in Septic Arthritis Diagnosis

The main objective of this study is to assess the ability of Fiber-optic Evanescent Wave Spectroscopy (FEWS) to discriminate synovial fluids samples of septic arthritis patients from other causes of joint effusion by analyzing ex vivo joint fluid samples collected during routine clinical care.


Eligibility Criteria:
Inclusion Criteria:

* patients benefiting from joint fluid puncture for diagnostic purposes in the rheumatology hospitals participating in the study
* patients over 18 year old,
* patients who received information about the protocol and have not expressed opposition to participate.

Exclusion Criteria:

* patients opposing the study,
* patients aged below 18 year old
* Protected major (safeguard justice , trusteeship and guardianship) and persons deprived of liberty
Effect of Integrated Neuromuscular Training on Medium Fast Bowler in Cricket

Effect of Integrated Neuromuscular Training on Explosive Strength, Speed and Endurance of Medium Fast Bowler in Cricket

Integrated neuromuscular training (INT) is a combination of functional movement training and speciﬁc strength, balance, speed, sensitivity, and isometric training, which aims to evaluate and prevent sports injury and improve sports performance. Neuromuscular control defects are mainly manifested as decreases in muscle strength, explosive power, or abnormal activation patterns. INT is deﬁned as a conceptual training program that incorporates general (e.g., fundamental movements) and speciﬁc strength and conditioning tasks (e.g., resistance, balance, agility, plyometric) to improve injury resilience and to enhance sporting and motor skill performance. The majority of studies in youth examining neuromuscular training strategies to improve performance and injury prevention include multiple components (for example, balance, strength, plyometric, agility, speed, coordination. INT sessions are characterized by short bursts of physical activity interspersed with brief rest periods.

the purpose of this study is to find the effect of integrated neuromuscular training on explosive strength, speed and endurance of medium fast bowler in cricket

Eligibility Criteria:
Inclusion Criteria:

* Medium fast bowlers
* Players playing cricket for \> 1 year
* Players engaging in cricket ≥ 3 days in a week

Exclusion Criteria:

* History of any injury in past 6 months.
* Those players having musculoskeletal, neurological, cardiorespiratory problems
* Those players who have any medical condition
A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)

To compile real-world outcomes of the Superion™ IDS in routine clinical practice.

To compile real-world outcomes of the Superion™ IDS in routine clinical practice, when used according to the applicable Directions for Use

Eligibility Criteria:
Key Inclusion Criteria:

* 45 years of age or older when written informed consent is obtained
* Persistent leg/buttock/groin pain, with or without back pain that is consistently relieved by flexion activities (example: sitting or bending over a shopping cart).
* Diagnosis of degenerative spinal stenosis of the lumbar spine, defined as the narrowing of the midline sagittal spinal canal (central) and/or narrowing between the facet superior articulating process (SAP), the posterior vertebral margin (lateral access), and the nerve root canal (foraminal).
* Subject signed a valid, IRB-approved informed consent form (ICF) provided in English.
* Subjects, who, in the opinion of the Clinical Investigator, are able to understand this clinical investigation, cooperate with the investigational procedures and are willing to return for all the required post-treatment follow-ups.
* Able to independently read and complete all questionnaires and assessments provided in English

Key Exclusion Criteria:

* Axial back pain only.
* Fixed motor deficit in lower extremity(ies) due to LSS.
* Has any pain-related diagnosis, medical/psychological condition or external factors that, in the investigator's medical judgment, might confound reporting of study outcomes (e.g. history of pelvic pain, anginal pain, chronic migraine, involved in litigation, workmen's compensation, spinal tumor)
* Participating (or intends to participate) in another drug or device clinical trial that may influence the data that will be collected for this study
Safety and Efficacy of MT-1303 in Subjects With Moderate to Severe Active Crohn's Disease

The primary objectives of the study are:

* To evaluate the safety and tolerability of MT-1303 in subjects with moderate to severe active Crohn's Disease（CD）
* To evaluate the clinical efficacy of MT-1303 in subjects with moderate to severe active CD.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of CD (involving small intestine and/or colon), confirmed by both endoscopy and histopathology at least 3 months prior to Visit 1
* Previous use of any type of corticosteroids or immunosuppressants for the treatment of CD
* Moderate to severe active CD defined by a CDAI score of ≥220 to ≤450 points at Visit 1

Exclusion Criteria:

* Diagnosis of ulcerative colitis, indeterminate colitis, pseudomembranous colitis or coeliac disease
* Enterocutaneous, abdominal or pelvic active fistulae, abscesses or fistulae likely to require surgery during the study
* GI surgery (including appendectomy) within 12 weeks prior to Visit 2 (Baseline) or has surgery planned or deemed likely to require surgery for CD during the study
Stress Echocardiography Versus Coronary Angiography for Left Main Stenosis Detection

Left main stenosis use to be treated by bypass but with the improvement of angioplasty techniques, an increasing number of patients are submit to left main coronary angioplasty. Consequences of left main intra stent stenosis can be disastrous yet, for the moment, no precise recommendation concerning the follow up of these patients exist. The investigators ought to determine if stress echocardiography can predict left main intra stent stenosis as well (non inferiorly)as control angiography that use to be done.

All patients of the study will pass coronary angiogram and stress echocardiography (treadmill of dobutamine).

Eligibility Criteria:
Inclusion Criteria:

* patients over 18 years old able to give consent and having had left main angioplasty.

Exclusion Criteria:

* Bypass on the left anterior descending coronary artery or left circumflex (" protected left main ")
* Treating physician judge that angiography need to be done straightaway
* Follow up elsewhere than the CHUS
* Patient refusal
* Pregnant women
* Stress echo contraindication(Severe high blood pressure or malignant arrhythmia)or condition that limits interpretation (Left bundle branch block or pacemaker rhythm)
Paula Method of Exercises in Patients With LARS Syndrome:Randomized Controlled Trial

Sphincter sparing rectal resection surgery, either total mesorectal excision (TME) with a temporary loop ileostomy or partial mesorectal excision (PME), is the mainstay of rectal cancer treatment , however, these treatments are associated with the development of Low anterior resection syndrome (LARS). This syndrome is characterized by a constellation of symptoms such as fecal frequency, urgency and clustering of bowel movements and can lead to fecal and flatus incontinence. There is no gold standard therapy designed to treat the root cause of the problems associated with LARS. Paula Method of exercises, based on the theory that the body has the natural ability to self-heal and that all sphincter muscles in the body affect one another other and thus, exercising one healthy region can positively impact another. The purpose of this study is to evaluate the usefulness of the Paula Method of exercises in patients post sphincter sparing rectal resection surgery with LARS Syndrome.


Eligibility Criteria:
Inclusion Criteria:

* patients 6-18 months post restorative surgery (either resection with a primary functional anastomosis or after the closure of a temporary ileostomy following curative surgery for rectal cancer) and, if applicable, at least one month post last adjuvant chemotherapy treatment
* LARS score of 21 or greater
* age 18 or older
* able to read and write in Hebrew or English
* able and willing to comply with the study requirements.

Exclusion Criteria:

* Chronic anal incontinence prior to surgery
* inability to perform exercises due to cognitive or physical limitations
* actively engaged in pelvic floor muscle exercises
* pregnancy.
A Smartphone-based Intervention for Diabetes Prevention in Overweight Chinese Adults With Pre-diabetes

Type 2 diabetes (T2DM) is a serious chronic condition and one of the world's fastest growing health problems. The onset of T2DM is gradual, with most individuals progressing through a state of pre-diabetes, which provides an important window of opportunity for the prevention of T2DM and its complications. This project aims to translate the evidence-based diabetes prevention strategies into community setting and utilize mobile health technology to reduce diabetes risks in Hong Kong.

Type 2 diabetes (T2DM) is a major global health issue and the cost to community is high and escalating. The Asia-Pacific region carries a high disease burden, with more than 60% of the global diabetic population living in Asian region. The onset of T2DM is gradual, with most individuals progressing through a state of pre-diabetes. A National Survey conducted in China in 2010 revealed that 50.1% of people aged 18 or older have pre-diabetes. People with pre-diabetes, defined as having impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or elevated glycated haemoglobulin (HbA1C) , are at increased risk of developing T2DM and its associated complications, such as heart diseases and retinopathy, which can develop even in the absence of progression to overt T2DM. Hence, it is essential that people with pre-diabetes are targeted for early intervention to prevent T2DM and related complications.

Obesity is a major risk factor for developing T2DM. International trials demonstrate that lifestyle interventions (which includes diet, physical activity and behavioural modification components) targeting at least 5% weight loss in individuals with pre-diabetes can reduce 3-year diabetes incidence by 58%. Growing evidence suggests that smartphones may be a promising platform for delivery of behavioural lifestyle intervention to achieve weight loss.

This project aims to translate the evidence-based diabetes prevention strategies into community setting and utilize mobile health technology to reduce diabetes risks in Hong Kong.

Eligibility Criteria:
Inclusion Criteria:

* Individuals aged 40 - 60 years old
* Overweight (BMI ≥ 23kg/m2) or obese (BMI ≥ 25 kg/m2)
* With at least one blood test result showing IGT (7.8-11.0 mmol/L after a two-hour glucose tolerance test), IFG (fasting glucose 5.6 - 6.9 mmol/L) or impaired HbA1c 5.7% - 6.4%
* Owns a smartphone
* Able to read Chinese and speak Cantonese.

Exclusion Criteria:

* With current or clinical history of T2DM, or with co-morbid conditions that may limit participation in the study, such as recent history of an acute cardiovascular event, uncontrolled hypertension, cancer or major psychiatric or cognitive problems
* Already participating in a weight loss programme
* Receiving drug treatment for pre-diabetes or long-term use of medicines known to influence glucose metabolism (e.g. corticosteroids)
Retroclavicular Approach vs Infraclavicular Approach for Plexic Bloc Anesthesia of the Upper Limb

Locoregional anesthesia provides several advantages over general anesthesia in terms of postoperative pain, decreased postoperative opioid needs and reduced recovery time for patients undergoing orthopaedic surgery.

For upper limb surgery, the coracoid infraclavicular brachial plexus block is generally preferred because of its simplicity and effectiveness but, needle visibility remains a challenge because of the angle between the ultrasound beam and the needle.

The retroclavicular approach for brachial plexus anesthesia requires an angle between the needle and the ultrasound beam that is less steep than the angle required to perform an infraclavicular coracoid block. This approach has already been proven effective and safe in the past.

The general objective is to provide a formal comparison between the retroclavicular approach and coracoid infraclavicular approach for brachial plexus anaesthesia. This study will delineate the differences between the two techniques.

Investigators aim is to compare both techniques in terms of scanning time, needling time, total anesthesia time, needle visibility, block needle passes, block success and early and late complications. Investigators made the hypothesis that, while providing similar efficacy and better needle visualisation than coracoid infraclavicular block, performance time of retroclavicular block will not exceed the performance time of its comparator.

This study is designed as a prospective randomized non-inferiority trial. Two groups of non-consecutive patients will be randomly assigned to either retroclavicular or coracoid infraclavicular block. This study will be carried out in three different centres simultaneously.

The multicentre trial will be conducted in two university hospitals (Centre hospitalier universitaire de Sherbrooke \[CHUS\] Hôtel-Dieu/Fleurimont and Centre Hospitalier de l'Université Laval \[CHUL\] in Quebec city) and a community hospital (Cowansville). The third participating establishment, Brome-Missisquoi-Perkins hospital, is located in Cowansville, a peripheral city of 15,000 people.

Eligibility Criteria:
Inclusion Criteria:

* Elective or urgent surgery of the hand, wrist, forearm or elbow.
* Age \>18 years old.
* ASA (American Society of Anesthesiologists) class 1, 2 and 3.
* Able to provide valid written consent.
* Minimum body weight of 50 kg, despite BMI

Exclusion Criteria:

* Patient refusal.
* Previous surgery or gross anatomical deformity of the clavicle.
* Systemic or local infection at needle entry point.
* Coagulopathy.
* Severe pulmonary condition.
* Local anaesthetic allergy.
* Pre-existing neurologic symptoms in the ipsilateral limb.
* Pregnancy.
* Surgical request of an indwelling catheter for post-operative analgesia
Effect of a Mix of Dairy Lipids and Plant Oils in Infant Formula on Omega-3 Fatty Acid in Red Blood Cells

The objective of this study is to determine whether the use of a mix of dairy lipids and plant oils in infant formula can increase the sum of omega-3 fatty acids levels in membrane phospholipids of red blood cells (RBC) in 4 month-old infants compared with a formula containing only lipids of plant origin.


Eligibility Criteria:
Inclusion Criteria:

* Full term healthy newborn from normal pregnancy
* Newborn whose mother decided to not breastfeed or to stop breastfeed before the third week of life

Exclusion Criteria:

* Newborn with low-birth-weight (\<2500 g)
* Newborn whose parents have planned a move within 6 months after birth
* Family history of allergy to milk protein
The Geneva Covid-19 CVD Study

In this study, the investigators propose to analyse the clinical data of all patients admitted in Geneva University Hospitals (HUG) or in a care center in Geneva who are diagnosed with COVID-19. CVD being one of the most important risk factors for developing a severe form of the disease, the investigators will explore the prognosis and clinical outcomes of those patients according to their CVD history as well as newly onset CVD during hospitalization. Moreover, as further evidence is needed on the use of renin-angiotensin-aldosterone system (RAAS) inhibitors for SARS-CoV-2 infected patients, the investigators will study prognosis and outcomes according to the patients' medications. Finally, the investigators propose to evaluate hospital length of stay and cost. The aim, therefore, is to collect information and scientific evidence from patients hospitalized and diagnosed positive for COVID-19, in order to evaluate if previous (or newly onset) CVD may influence outcomes and costs.

Hypothesis:

COVID-19+ hospitalized patients with preexisting CVD or newly onset CVD at time of hospitalization have different clinical outcomes compared to those without CVD and COVID-19+.

Objectives:

The primary aim of this study is to gather observational data, starting from February 1st 2020 until the end of the pandemic, to compare clinical outcomes COVID+ hospitalized patients at HUG or in a care center in Geneva with pre-existing or newly onset CVD, to COVID+ hospitalized patients at HUG or in a care center in Geneva without pre-existing CVD.

The secondary aims of this study are:

* To determine the association between COVID-19 disease and CVD, based on: age, previous CV diseases, CV risks factors, CV medications (e.g. ACE Inhibitors or angiotensin II receptor antagonists)
* To explore CVD profiles that may influence COVID-19 disease outcomes
* To determine the cause of death in CVD patients (either with preexisting CVD or newly diagnosed with CVD)
* To understand the vulnerability of the myocardium (new event of either heart failure, acute coronary syndrome, arrhythmia, myocarditis) in patients with COVID-19 disease.

Eligibility Criteria:
Inclusion Criteria:

* Subject is ≥18 years of age.
* Patient diagnosed SARS-CoV-2 positive at time of hospitalization.
* In case of the subject accepting the follow-up at 30 days and 1 year, Signed Patient Informed Consent (PIC) form

Exclusion Criteria:

* Patients unwilling to provide informed consent for the follow-up.
A Comparative Study of the Efficacy of Multimodal Interventions for Tenosynovitis

The goal of this clinical trial is to compare the efficacy of four treatments in patients with hand tenosynovitis. The main questions it aims to answer are:

Which treatment most effectively reduces pain and improves joint function? How do the treatments differ in improving strength and range of motion? Researchers will compare four groups-basic manipulation, tui na manipulation, blood flow restriction (BFR) training, and magnetic bead application combined with tui na-to see if there are differences in clinical outcomes.

Participants will:

Be randomly assigned to one of the four treatment groups. Receive interventions twice a week for 4-8 weeks. Undergo assessments of pain, function, range of motion, and strength before, during, and after the treatment period.


Eligibility Criteria:
Inclusion Criteria:

* 18 to 60 years of age.
* Case diagnosis reporting symptoms of tenosynovitis of the hand for at least 3 months.
* Constant-Murley Shoulder Score: score less than or equal to 60.
* Dysfunction of the Upper Extremity, Shoulder, and Hand Scale (DASH Scale): DASH score less than 40.
* Mayo Wrist Score: score less than or equal to 60.
* Positive test results on 2 or more scales during pre-test screening.
* No structural lesions or congenital malformations of the hand or wrist.
* Finkelstein's Test: Positive (pain occurs when patient holds thumb and bends wrist toward little finger).
* Fist Clenching Test: Positive (pain increases when patient clenches fist and attempts to bend wrist toward little finger).
* No prior hand or wrist surgery or external injuries.
* No serious cardiac, pulmonary, neurological, or other systemic diseases.
* Sufficient exercise capacity to complete exercise loads of required intensity and duration.

Exclusion Criteria:

* Not between 18 and 60 years of age.
* Failed wrist function screening.
* Failed special tests.
* Presence of structural wrist lesions or congenital wrist deformities.
* History of wrist surgery, significant trauma, or wounds.
* Problems with skin irritation, infections, or open wounds.
* Conditions like anemia or low blood pressure.
* Serious cardiac, pulmonary, neurological, or other systemic diseases.
* Inability to cooperate with trial requirements or refusal to participate.