cyrilzakka/clinical-trials huggingface dataset:
Biochemical Diagnostics of Mild Traumatic Brain Injury (TBI) and Concussion in Children and Adolescents

The study will enroll children and adolescents (0 - 17 years) suspected of having concussion or mild traumatic brain injury (TBI). Samples of urine and saliva will be collected from the patients as well as from corresponding age- and gender-adjusted healthy controls.

The collected samples will be alienated to the Sponsor who will perform biochemical studies to identify and measure from the samples relative level of the brain injury-specific biomarkers.

Eligibility Criteria:
Inclusion Criteria:

* The subject is suspected of having an isolated mild TBI (Glasgow Coma Score 13 - 15)
* No more that 6 hours elapsed from the incident of injury at the first sampling
* The patient is conscious
* Informed consent received from the legal guardian, and the subject him-/herself when literate and capable of understanding study measures

Exclusion Criteria:

* More than 6 hours elapsed from the injury, or unknown time of trauma
* Multi-trauma patient
* History of head injury, seizures or stroke within three preceding months
* Chronic neurodegenerative, metabolic or autoimmune disease
* Known existing neurological condition
Efficacy and Safety Study of Ingavirin® to Treat Influenza and Other Acute Respiratory Viral Infections in Patients 3-6 y.o.

The purpose of this study is to determine whether Ingavirin ® dosed 30 mg daily is effective and safe in the treatment of influenza and other acute respiratory viral infections in the course of standard therapy in 3-6 years old patients.


Eligibility Criteria:
Inclusion Criteria:

* The informed consent form signed by the patient's parent/adoptive parent to participate in the clinical study.
* Male and female patients aged 3-6.
* Patients with moderate course of influenza or other acute respiratory viral infections.
* Patients with clinically diagnosed influenza or other ARVI based on the body temperature \> 37,5 ° C, not less than 1 of the following other symptoms of intoxication and not less than 1 of the following of catarrhal symptoms:

  * Intoxication symptoms: headache, malaise, myalgia, pain in the eyeballs;
  * Catarrhal symptoms: sore throat, rhinorrhea, cough, nasal congestion.
* Established diagnosis J06.9, J10, J11, in accordance with ICD-10.
* Uncomplicated course of influenza and other ARVI.
* Interval between onset of symptoms and enrollment to the study of not more than 36 hours.

Exclusion Criteria:

* Complicated course of influenza and other acute respiratory viral infections.
* Treatment with antiviral drugs (antivirals, interferons and interferon inducers), drugs with immunomodulatory effects or antibiotics with systemic and local action within 14 days prior to the screening visit.
* Severe influenza or other ARVI with symptoms of cardiovascular disease, and other symptoms of infectious-toxic shock, and meningoencephalitic syndromes.
* Signs of primary viral pneumonia development (presence of two or more of the following symptoms): shortness of breath, chest pain when coughing, systemic cyanosis, dullness of percussion sound at symmetrical assessment of the upper and lower parts of the lungs.
* Infectious diseases within the last week prior to enrollment.
* "RRI children" (incidence of ARVI within the last 12 months is 6 times or more).
* Asthma history.
* History of increased seizure activity.
* Severe decompensated or unstable medical or psychiatric conditions (any diseases or conditions that threaten the life of the patient or worsen the patient's prognosis and also make it impossible to conduct a clinical study in the patient).
* Cancer, HIV infection, tuberculosis, including those in history.
* Hypersensitivity to imidazolyl ethanamide pentandioic acid and/or excipients of Ingavirin product.
* Diabetes, lactose intolerance, lactase deficiency, glucose-galactose malabsorption, deficiency of sucrase/isomaltase, fructose intolerance, hereditary glucose malabsorption, deficiency of glucose-6-phosphate dehydrogenase.
* Participation of the patient in any other clinical trial within the last 90 days prior to enrollment.
Effects of Active Tissue Release Techniques on Groin Pain in 2nd Trimester of Pregnancy

The study will focus on the effects of active tissue release techniques on groin pain, hip range of motion, and functional disability in 2nd trimester of pregnancy. This will be a randomized controlled trial conducted on 30 participants from Prime Care Hospital. Pregnant women in the second trimester aged between 25 to 35 years, who have groin or round ligament pain will be included in this study. A sample of 30 will be divided into 2 groups. Group A will undergo treatment of active release techniques for 10 minutes thrice a week with no home plan of home relaxation exercises. In contrast, Group B will combine treatment of active release technology with home relaxation exercises. Treatment will be given for 4 weeks and pain will be assessed before and after the treatment through (NPRS) scale. Functional disability will be measured before and after the treatment through Quebec scale and Force Disability Scale Questionnaire in both groups.

Groin pain mostly occurs in the first and second trimesters of pregnancy due to round ligament pain because the womb expands and causes stretching of ligaments making it more likely to become strained. The study will be focused on the effects of active tissue release techniques on groin pain, hip range of motion, and functional disability in 2nd trimester of pregnancy. A baseline treatment of ice therapy will be given for 10 minutes to all participants of this study. A sample of 30 will be divided into 2 groups. Group A will undergo treatment of active release techniques for 10 minutes thrice a week with no home plan of home relaxation exercises. In contrast, Group B will combine treatment of active release technology with home relaxation exercises.

Treatment will be given for 4 weeks and pain will be assessed before and after the treatment through (NPRS) scale. Functional disability will be measured before and after the treatment through the Quebec scale and Force Disability Scale Questionnaire in both groups. Recorded values will be analyzed for any change using SPSS

Eligibility Criteria:
Inclusion Criteria:

* Pain in the groin area/ Round Ligament pain
* NPRS scores between 4 to 10
* Functional activities scoring between 50 to 90 at Quebec score

Exclusion Criteria:

* Any diagnosed pathology like infection , malignancy ,inflammation
* Any structural deformity of lumbar and pelvic girdle,
* Any inguinal or lumbar surgery
* High risk pregnancy
Virtual Reality Exposure Versus In Vivo Exposure for Fear of Heights

This study randomly assigned 114 participants with significant fear of heights to one of three conditions: a) a single session of virtual reality exposure; b) a single session of in vivo exposure; or c) a control condition. The aim of this study was to compare the efficacy of virtual reality exposure to the efficacy of in vivo exposure or no exposure for participants with significant fear of heights.


Eligibility Criteria:
Inclusion Criteria:

* Score \>= 45 on the Acrophobia Questionnaire (AQ)

Exclusion Criteria:

* Already receiving therapy specifically for fear of heights.
* Has any contraindications to using a virtual reality headset.
One-year Outcome After Prehospital Intubation

The primary aim of this study was to describe the long-term outcome of critically ill or severely injured patients not in cardiac arrest treated by an EMS physician.

The aim of helicopter emergency medical services (HEMS) is to supplement ground EMS units in the care of prehospital patients. The need for advanced airway management in critical out-of-hospital patients can be considered as one indicator of the severity of the patient's condition.

A recent European initiative suggested advanced airway management to be included in the top five research priorities for physician-provided prehospital care.To our knowledge, no previous studies describe the long-term outcome of critical prehospital patients treated by an EMS physician.

The primary aim of this study was to describe the long-term outcome of critically ill or severely injured patients not in cardiac arrest treated by an EMS physician. Our secondary aims were to determine the indications and causes for EMS physician performed prehospital endotracheal intubation.

Eligibility Criteria:
Inclusion Criteria:

* All non-cardiac arrest patients.

Exclusion Criteria:

* Patients with a known need for personal assistance in activities of daily life prior to the incident leading to prehospital intubation (outcome evaluation).
* Patients intubated by EMS before HEMS arrival.
* Death on scene or during transportation.
Effect of a Web Page Based on a Motivational Video for Voluntary Blood Donation

Voluntary blood donation is currently a key issue in many countries, as the shortage of voluntary donors results in a deficit in the supplies of the Blood Banks of the hospitals. One factor for which there is a low number of voluntary donors is the limited dissemination of information that is given to the population regarding the facilities and benefits of blood donation.

Objective: To evaluate the effect of a web page containing a motivational video and an informative text to promote the voluntary donation of blood disseminated through the use of social networks such as Facebook and WhatsApp.

Design and Participants: Online randomized controlled trial for a group of 102 university students.

Intervention: One group exposed to the intervention with video and the other control group exposed to informative text.

PROBLEM STATEMENT The shortage of voluntary blood donors is a constant worldwide problem, since many lives depend on a transfusion every day to carry out medical or surgical treatment, however, the demand is so high that it exceeds the available number of units of blood. That is why the WHO recommends that at least 2% of the total population donate blood to supply the national demand for blood units. It is known that Peru needs around 520,000 units of blood per year to be able to supply the national demand of blood banks (19). In 2017, only 1.08% of the Peruvian population donated blood.

The shortage of blood supply in the blood banks of hospitals is a problem worldwide. The demand for blood has increased in recent decades. This is because blood and its derivatives are used to attend to procedures that support the patient's well-being. It is due to this high demand that all the countries of the world have found themselves in need of generating national laws and systems that help to boost research and voluntary blood donation.

When developing strategies for the promotion of the voluntrary blood donation, it is necessary to know the perceptions that donors have regarding the donation. A study conducted in a hospital in Lima showed the positive and negative aspects regarding blood donation, which resulted in one of the negative aspects is the limited publicity that is given regarding the blood donation. The donors interviewed suggested that advertising could be done through the internet, spreading the information through emails or through the use of Facebook.

HYPOTHESIS It is proposed that there is a significant difference in the increase in the intention to donate blood voluntarily after exposing the participants to a motivational video about blood donation compared to participants exposed to an informative text about blood donation. Both groups will receive the information (video or text) through a web page.

Eligibility Criteria:
Inclusion Criteria:

* Be between 18 and 30 years old.
* Be a student of the Universidad Peruana Cayetano Heredia.
* Never donated blood

Exclusion Criteria:

-Denial to participate in the study.
Carbohydrates and Related Biomarkers

This study is designed to investigate associations of low- and high-glycemic load diets with biomarkers of hyperglycemia, hyperinsulinemia and inflammation, potential biomarkers for cancer risk.

This is a randomized, crossover feeding study conducted in normal weight and overweight individuals. Participants will be given all their food to eat and drink (except water) for two 28-day feeding periods (a total of 56 days). The diets will be carefully controlled and energy intake will be regulated to maintain weight stability for each participant. The two feeding periods will be separated by a 28 day "washout" period when participants will eat their own food. Dinner will be eaten at the Hutchinson Center Monday through Friday. Each evening, breakfast, lunch and snacks will be brought home for the next day. On Friday evenings all the food will be taken home for the weekend.

Samples of blood will be collected after an overnight fast at the beginning and the end of each feeding period. All urine will be collected for 24 hours at the end of each feeding period. A number of questionnaires will also be completed during each diet period. A small stool sample will be collected in your own home, before the first feeding period, and once during each feeding period. The stool sample collection is optional. One can decide not to provide a stool sample and still participate in the study.

Eligibility Criteria:
Inclusion Criteria:

1. Healthy males and female subjects
2. Between the ages of 18 to 45
3. BMI between 18.5 kg/m2 to 24. 9 kg/m2 (normal weight) and between 28.0 kg/m2 to 39.9 kg/m2 (overweight)
4. Willingness to refrain from alcohol during the study
5. Able to come to the FHCRC in Seattle every weekday night for dinner

Exclusion Criteria:

1. Younger than 18 years of age or older than 45 years of age.
2. Do not fit into one of the study weight groups (normal weight and overweight): BMI \< 18.5 kg/m2 or \> 40.0 kg/m2, and between 25.0 kg/m2and 27.9 kg/m2
3. Have diseases that are treated by diet and/or medications including but not limited to diabetes, kidney disease, heart disease
4. Taking prescription medications every day (this includes women taking birth-control pills, shots, patch or IUD with hormones)
5. Diagnosed with or treated for cancer within the previous five years (except those with a diagnosis and/or treatment of non-melanomatous skin cancer are eligible)
6. Currently pregnant or breastfeeding or planning a pregnancy in the next 3 months.
7. Using any tobacco products on a daily basis (cigarettes, pipes, cigars, chewing tobacco).
8. Using recreational drugs
9. Drinking the following amount of alcohol almost every day: 2 or more cans/bottles of beer OR 2 or more glasses of wine OR 3 or more ounces of hard liquor.
10. Inability (e.g., food allergy or intolerances) or unwillingness to consume the foods that are part of the feeding study diet.
Additional Protein Fortification in Extremely Low Birth Weight Infants

Postnatal growth is a crucial in premature infants as it could be correlated with the long-term cognitive development. Optimal nutritional care is required to reduce the initial weight loss and further growth deficit.

The quantitative objective is to achieve growth that is at least equivalent to that of the fetus (on average 15 g/kg.day (12-18 g/kg.day according to gestational age). Children often grow during difficult 10-15 first days of life, so they accumulate a delay that should compensate them secondarily. Therefore, optimum postnatal growth is rather 20 g/kg.day than 15 g/kg.day.

Individualized fortification of human milk (HM) has been proposed to optimize postnatal growth. Specifically, the lack of protein intake is responsible for sub-optimal postnatal growth in preterm infants.

The objectives of this study are to determine the effectiveness of additional protein fortification (APF) in terms of short-term growth along with the proportion of extremely low birth weight (ELBW) infants requiring APF.

In a retrospective, single-center study, premature infants weighing \<1250 g at birth hospitalized in investigators' neonatal intensive care unit in 2012, who were exclusively fed with fortified HM and received APF for \>12 consecutive days were included.

Weight gain (g/kg•d) over the previous 7 days was calculated daily based on weight data in patients' electronic medical records. When weight gain was considered insufficient (i.e., below 20 g/kg•d) and the serum urea level was \<3 mmol/L, 1 g/kg•d protein was added. Before using the mixture, investigators verified that the osmolality was only slightly increased (from 412 to 422 mOsm/kg).

Growth and digestive tolerance were compared between the week before (Wk0) and 1 and 2 weeks after (Wk1 and Wk2, respectively) the introduction of protein supplement; each participant served as his own control. Change from baseline for body weight was the main outcome. Energy and protein intake during Wk0, Wk1, and Wk2 were calculated. Standard deviation z-scores for growth parameters were calculated 7 days before, at time of protein introduction, and 7 and 14 days after . Changes in Z-scores were calculated. The digestive tolerance score and metabolic tolerance (serum urea) were assessed during Wk0, Wk1, and Wk2 (5).

Eligibility Criteria:
Inclusion Criteria:

* infants weighing \<1250 g at birth
* exclusively fed with fortified HM

Exclusion Criteria:

- Severe malformations
Effect of Massage on Chronic Low Back Pain

This study will evaluate the effectiveness of two types of massage therapy for treating chronic low back pain.

Americans are increasingly seeking care from massage therapists for relief of chronic back pain. However, while initial studies suggest that massage is beneficial for back pain, we have no information about which of the many types of massage is most helpful. We will be conducting a study that compares two distinct therapeutic massage protocols with each other and with usual care for treating chronic back pain. This study is designed to determine which of these massage protocols will be most effective in reducing pain and increasing functionality in people with low back pain. 399 Group Health members with non-specific low back pain lasting at least 3 months will be randomized to one of the two massage groups or to a control group that receives no treatment beyond their usual care. Massage therapists will provide each participant with 10 treatments over 10 weeks. The primary outcomes, function and bothersomeness of low back pain, will be assessed before treatment begins and 10, 26 and 52 weeks after randomization by interviewers who do not know which treatment the participant received. The results of this study will clarify the value of two different types of massage for treating one of the most common, challenging, and expensive health problems plaguing developed countries. The findings will help physicians make informed and confident referrals, consumers and insurers make safe and cost-effective choices, and massage schools make responsible curriculum decisions.

Eligibility Criteria:
Inclusion Criteria:

* 20 through 64 years of age
* members of Group Health Cooperative health plan
* low back pain lasting at least 3 months

Exclusion Criteria:

* non-mechanical causes of back pain (e.g., sciatica, systemic/visceral disease, pregnancy, spondylolisthesis, spinal stenosis, cancer, recent vertebral fracture)
* inappropriate candidate for massage (active open skin lesions, conditions exacerbated by increased circulation, recent strokes or heart attacks, compromised immune system, systemic edema, hypersensitivity to touch or loss of sensation, recent surgery, active contagious infection)
* characteristics complicating the interpretation of findings (e.g., involved with litigation or compensation claim, severe or progressive neurological deficit, back surgery within last 3 years, receiving other back treatment)
* unable to speak or read English
* had massage for any reason in prior 12 months
Impact of Nitrate Ingestion on Protein Synthesis

A diet rich in leafy green vegetables has been shown to reduce the risk of developing chronic metabolic disease. The health benefits from these particular vegetables may be attributed to their high nitrate content. Recent work suggests that dietary nitrate triggers endogenous nitric oxide release, thereby stimulating vasodilation and improving muscle perfusion in an insulin-independent manner. We hypothesize that in an insulin-resistant state, nitrate co-ingestion will increase muscle perfusion, thereby improving post-prandial delivery of nutrients to skeletal muscle tissue. Specifically, a more efficient delivery of food derived amino acids will stimulate post-prandial muscle protein synthesis and, as such, compensate for a blunted muscle protein synthetic response to food intake in the elderly. This proposal will investigate the efficacy of nitrate co-ingestion as a means to augment muscle protein synthesis in elderly, type 2 diabetes patients and may lead to a novel therapy in the clinical care of type 2 diabetes patients.


Eligibility Criteria:
Inclusion Criteria:

* Male
* Aged between 70-85 years
* BMI \< 30 kg/m2
* Non insulin-dependent diabetes mellitus type 2 patients (T2DM) ( \>1 y since diagnoses)

Exclusion Criteria:

* Smoking
* Hypertension (according to WHO criteria)\[29\] and/or cardiovascular disease treated with medication containing nitrates and/or having vasodilatory effects
* Use of medication, except for oral blood glucose lowering medication
* Use of insulin
* All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
* HbA1c \> 10.0% (86 mmol/mol)
* Donated blood in last 3 months
* Diagnosed impaired renal or liver function
* Myocardial infarction within the last 3 years
* Gastric acid inhibitors
* Use of anti-coagulants
Lower Urinary Tract Symptoms in Males Living With HIV

The primary aim of this study is to learn whether the frequency of lower urinary tract symptoms differ between the males with seronegativity for HIV and males living with HIV.


Eligibility Criteria:
Inclusion Criteria:

* Patients above 18 years old

Exclusion Criteria:

* Non-Turkish speakers
* Previous surgeries or medications for lower urinary tract symptoms
Optical Coherence Tomography in STEMI

The overall objective of this research proposal is to use OCT to investigate those morphological culprit plaque characteristics associated with the risk of developing MVO in reperfused STEMI patients.

The specific research objectives include:

1. To use OCT to determine the type of plaque (plaque rupture, plaque erosion or calcified nodule) most associated with the presence and severity of MVO (as measured by IMR and cardiac MRI).
2. To use OCT to investigate the relationship between the extent of tissue protrusion and the amount of residual stent thrombus with the presence and severity of MVO (as measured by IMR and cardiac MRI).

Eligibility Criteria:
Inclusion Criteria:

1. Confirmed STEMI as per the in-charge consultant based on presenting history, ECG and angiogram findings.
2. \< 12 hours of onset of chest pain.
3. Ability to provide informed consent

Exclusion Criteria:

1. Previous myocardial infarction or coronary artery bypass graft surgery
2. Cardiac arrest or cardiogenic shock
3. Inability to advance the OCT catheter or to obtain good image quality
4. Ostial lesions
5. Significant renal impairment
6. Contraindications for cardiac MRI
7. Contraindication for adenosine (for IMR measurement)