Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of Selicrelumab (RO7009789) With Vanucizumab or Bevacizumab in Participants With Metastatic Solid Tumors

This open-label, two-part study is designed to assess the safety, PK, PD, and therapeutic activity of Selicrelumab in combination with vanucizumab or bevacizumab in participants with metastatic solid tumors not amenable to standard treatment. Part I (dose escalation) is designed to establish the maximum tolerated dose (MTD) of Selicrelumab in this combination. Part II (expansion) is intended to characterize the safety and tolerability of Selicrelumab in combination with bevacizumab among indication-specific cohorts and to confirm the recommended dose.


Eligibility Criteria:
Inclusion Criteria:

* Part I: Histologically confirmed advanced/metastatic solid tumor (except prostate cancer and squamous non-small cell lung cancer \[NSCLC\])
* Part II: Histologically confirmed advanced/metastatic platinum-resistant ovarian carcinoma (aPROC), head and neck squamous cell carcinoma (HNSCC), or non-squamous NSCLC previously treated with anti-PD-L1/PD-1 inhibitor alone or in combination (e.g. atezolizumab, nivolumab, pembrolizumab, durvalumab, avelumab)
* Checkpoint inhibitor (CPI)- experienced patients must have experienced documented disease progression on or after PD-L1/PD-1 inhibitor therapy
* In CPI-experienced patients, the PD-L1/PD-1 inhibitor must have been part of the most recent systemic anticancer therapy administered prior to study enrollment
* Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
* Life expectancy \>/= 16 weeks
* Adequate hematologic, renal, hepatic, and cardiovascular function
* Measurable disease per Response Evaluation Criteria in Solid Tumors, v 1.1 (RECIST v1.1)
* Tumors must be acceptable for biopsy. Participants in Part II may be enrolled without a biopsy if the collection is not clinically feasible.
* Agreement to use adequate contraceptive measures among men or among women of childbearing potential

Exclusion Criteria:

* Prostate cancer or squamous NSCLC
* Recent systemic anti-cancer treatment
* Prior treatment with anti-programmed death (PD) 1 or anti-programmed death ligand (PD-L) 1 therapeutic antibody, vanucizumab, or compounds targeting cluster of differentiation (CD) 40 less than 4 weeks or 5xt1/2 (whichever is shorter) prior to enrollment
* Part II: Treatment targeting vascular endothelial growth factor (VEGF) or receptor within 12 months prior to enrollment
* Systemic immunosuppressive medication within 2 weeks prior to day 1 of cycle 1
* Chronic daily treatment with non-steroidal anti-inflammatory drugs
* Unacceptable/unresolved toxicity from prior anti-cancer therapy
* Patients who have had a surgical procedure or significant traumatic injury within 28 days prior to initiation of study treatment, or a core biopsy or other minor surgical procedure within 7 days prior to initiation of study treatment
* Bisphosphonate therapy for symptomatic hypercalcemia
* Significant vascular disease
* History of hypertensive crisis or hypertensive encephalopathy
* Current or recent use of aspirin (\>325 mg/day) or clopidogrel (\>75 mg/day)
* History of vein thrombosis/thromboembolism, or use of anticoagulants within 7 days prior to study drug
* Primary tumor in place in participants with colorectal cancer, or evidence of bowel involvement (metastasis, direct tumor invasion) in participants with other non-gastrointestinal cancer
* Significant cardiovascular or cerebrovascular disease within 6 months prior to D1 of C1
* History of fistula, bowel obstruction, perforation, or abscess
* Prior radiotherapy to pelvis or abdomen, recto-sigmoid involvement, or bowel involvement among participants with aPROC
* Severe non-healing wound, active ulcer or untreated bone fracture
* Pregnant or lactating women
* History of autoimmune disease
* Human immunodeficiency virus (HIV) or hepatitis B or C
* Severe infection or receipt of a live/attenuated vaccine within 4 weeks prior to D1 of C1
* Other significant malignancies within 3 years prior to D1 of C1
* Allergy/hypersensitivity to study drug
* Prior allogeneic bone marrow or solid organ transplant
* Other conditions/findings that may contraindicate use of study drug
* Major surgery within 4 weeks prior to study drug
* Known clinically significant liver disease
* History of hemoptysis or bleeding diathesis, or known coagulopathies
* Known symptomatic or untreated central nervous system (CNS) malignancy