cyrilzakka/clinical-trials huggingface dataset:
Evaluation of a Hemostatic and Sealing Agent to Prevent Surgical Complications After Axillary Lymphadenectomy

This study was intended to assess the value of a hemostatic and sealing agent, a collagen sponge coated with human coagulation factors (fibrinogen and thrombin) (TachoSil®), for decreasing occurrence of seroma after axillary lymphadenectomy.


Eligibility Criteria:
Inclusion Criteria:

* Patients with axillary lymphadenectomies performed for oncological conditions.

Exclusion Criteria:

* Patients that did not want to participate in the study.
Transmuscular Quadratus Lumborum Block Plus Pericapsular Injection vs Pericapsular Injection

The purpose of this research study is to compare two different treatment options on their effectiveness to reduce post-operative pain, narcotic (opioid pain medication) usage and recovery time in patients undergoing primary hip arthroscopy surgery.

The first treatment option is a Transmuscular Quadratus Lumborum (TQL) block plus hip incision site (Pericapsular) Injection. The TQL block is an ultrasound guided injection between the quadratus lumborum and the psoas muscles in the back. The anesthesiologist will perform the TQL block The second treatment option is only a hip incision site (Pericapsular) Injection. In this group, the surgeon will inject local anesthetic into the incision or hip portal sites to decrease sensation.

This is a phase IV, randomized, single-blind, single-center study comparing postoperative pain, opioid usage and Post-Anesthesia Care Unit (PACU) recovery time for patients who receive a Transmuscular Quadratus Lumborum block (TQLB) plus pericapsular injection versus pericapsular injection (PCI) undergoing primary hip arthroscopy.

Eligibility Criteria:
Inclusion Criteria:

* Patients between 18 and 65 years of age
* Patients undergoing Primary Hip Arthroscopy
* Patients diagnosed with femoroacetabular impingement (FAI)
* Patients who consent to be randomized.

Exclusion Criteria:

* Patients younger than 18 and older than 65;
* Patients with a history of chronic pain that have used opioids for pain management for 3 months or longer;
* Patients with diagnosed or self-reported cognitive dysfunction;
* Patients with a history of neurologic disorder that can interfere with pain sensation;
* Patients with a history of drug or recorded alcohol abuse;
* Patients who are unable to understand or follow instructions;
* Patients with severe liver disease, renal insufficiency, congestive heart failure, and/or significant heart disease;
* Patients with an allergy or contraindication to any of the medications used in the study, or patients with a contraindication to any study procedures;
* Patients with BMI over 40;
* Any patient that the investigators feel cannot comply with all study related procedures.
SOTO: Treatment Sensitivity of Organoids to Predict Treatment Outcome

In this study, we aim to assess whether Patient Derived Organoids can be used to predict treatment sensitivity in HNSCC patients.

This is a prospective observation study to generate patient-derived organoids from patients' samples to assess treatment response and to correlate with patients' treatment outcomes and to collect preliminary data on the ability of PDOs to predict patients' treatment response and whether their radiosensitivity and chemosensitivity can be correlated with their survival outcome.

Eligibility Criteria:
Inclusion Criteria:

* Patients with head and neck squamous cell carcinoma (including oral cavity, oropharynx, paranasal sinuses, hypopharynx or larynx) undergoing curative treatment (primary surgery or radiotherapy) or presenting with recurrent or metastatic cancers
* Age \> 18 years old

Exclusion Criteria:

* Patients unable to give informed consent e.g. mental disability or vulnerable adults
Bioenergy, Depression, Anxiety and Stress After Liver Transplantation

In this study, the investigators aimed to examine the effect of bioenergy application on depression, anxiety and stress after liver transplantation.

Simple random sampling method was used to assign liver recipients to experimental and control groups. Discharged liver transplant patients will be investigated for anxiety, stress and depression.

Eligibility Criteria:
Inclusion Criteria:

(i) liver transplant recipient (ii) must be able to use immunosuppressive agents (iii) 18 years or older Liver transplant recipients

Exclusion Criteria:

having psychiatric problems having language and communication problems
ScreenIng of Genetic Susceptibility Genes for Breast Cancer Patients in CHinese communiTies

This is a community-based prospective study and the research object is breast cancer patients. It is planned to take the community as the unit to inform and collect the breast cancer patients who voluntarily participate to carry out the detection of BRCA1, BRCA2, PTEN, CHEK2 and PALB2 genes through the community health service center.

This is a population-based, prospective, cohort study which has been ongoing in 3 provinces of eastern China since 2019. Up to 5000 breast cancer survivors will conduct BRCA1, BRCA2, PTEN, CHEK2, and PALB2 genetic susceptibility genes testing, fill in clinical and genetic information forms, and collect family history. Mutation rate of BRCA1/2 and other genetic susceptibility genes in Chinese community breast cancer population will be measured. Logistic regression will be performed to establish a prediction model for the probability of BRCA1/2 and other gene mutations. Kin-Cohort method will be used to calculate the penetrance of breast cancer and other common malignancies in BRCA1/2 and other genetic mutation carriers.

Eligibility Criteria:
Inclusion Criteria:

* breast cancer patients of any age;
* both male and female;
* the subjects signed the informed consent to participate in the study and abide by the study procedure before being selected.

Exclusion Criteria:

* healthy people or other malignant tumor patients without breast cancer;
* unable to interview the investigator and sign the informed consent due to any reason;
* it is impossible to collect peripheral blood or oral mucosa samples for any reason.
SELF - BREATHE for Chronic Breathlessness

Semi-structured qualitative interviews will be conducted to understand key factors that would enable / facilitate patients with chronic breathlessness to potentially use an online breathlessness intervention (SELF-BREATHE).

STUDY OVERVIEW

Full title:

A self -guided, internet -based intervention for patients with chronic breathlessness (SELF-BREATHE): an interview study.

Objective:

To understand the key factors that would enable / facilitate patients with chronic breathlessness to use an online breathlessness support intervention (SELF-BREATHE).

Study type:

Qualitative interview study

Methods:

Semi-structured qualitative interviews will be conducted to achieve maximum variation in approx 20 patients with chronic breathlessness (a purposive sample: age sex, diagnoses, and presence of caregiver).

The interview will explore and identify:

Patients' views/experiences of internet-based activities, e.g. digital apps, shopping online; Patients' understanding, preferences, values and motivations that would influence uptake of SELF-BREATHE; Potential barriers to the development and use of SELF-BREATHE; Facilitators to usage of SELF-BREATHE, such as the ability to self-monitor progress etc...

These topics cover areas of uncertainty in order to optimise the SELF - BREATHE intervention.

Inclusion criteria:

Adult patients \>18 years of age, with the ability to read, converse in English and able to provide informed consent

Chronic breathlessness on exertion and or rest (MRC dysponea score \>2)

Advanced disease such as cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF) or interstitial lung disease (ILD), where the underlying disease is deemed to be optimally medically managed by the referring clinician / allied health professional / clinical nurse specialist

Exclusion criteria:

Breathlessness of unknown cause

A primary diagnosis of chronic hyperventilation syndrome

Eligibility Criteria:
Inclusion Criteria:

* Adult patients \>18 years of age, with the ability to read, converse in English and able to provide informed consent
* Chronic breathlessness on exertion and or rest (MRC dyspnea score \>2)
* Advanced disease such as cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF) or interstitial lung disease (ILD), where the underlying disease is deemed to be optimally medically managed by the referring clinician / allied health professional / clinical nurse specialist

Exclusion Criteria:

* Breathlessness of unknown cause
* A primary diagnosis of chronic hyperventilation syndrome
The Role of Acute Combined PPAR Alpha and Gamma Stimulation on Insulin Action in Humans

The purpose of this study is to investigate the acute effects of the thiazolidinedione agent pioglitazone (which has combined PPAR alpha and gamma stimulation) on insulin's ability to suppress glucose production, stimulated glucose uptake, and impact a number of other metabolically important endpoints, including production of adiponectin (a protein hormone which regulates sugar levels and fatty acid breakdown) in subjects with type 2 diabetes.

Participants in this study were given a supply of either pioglitazone (a medication used to treat diabetes) or matched placebo for a duration of 10 days or 21 days. Changes to the body's response to insulin in the liver and in peripheral tissues (eg, muscle and fat) will be measured using a procedure called a pancreatic clamp. During the clamp procedure, glucose (a sugar) and insulin were infused with an intravenous catheter, and blood samples were collected periodically throughout the procedure to measure blood sugar levels and the levels of several hormones that are found in the body and are related to glucose metabolism. Small amounts of muscle and fat tissue were also taken during this study to measure changes in gene expression after taking the medication/placebo.

Eligibility Criteria:
Inclusion Criteria:

• Individuals with Type 2 Diabetes

Exclusion Criteria:

* Individuals with bleeding disorders including gastrointestinal reflux disease (GERD), peptic ulcer disease (PUD), any gastrointestinal (GI) bleeding
* High blood pressure
* History of Coronary Artery Disease or chest pain on exertion
Study on the Performance of Symmcora® Mid-term Suture Versus Novosyn® Suture in Patients Undergoing Robotic Assisted Gastric Bypass Surgery

The study is designed as a prospective, mono-centric, randomized, patient blinded comparison of unidirectional barbed suture (Symmcora® mid term, UBS) vs. a conventional suture (Novosyn®, CS). Patient will be randomly allocated in a 1:1 ratio to either the UBS group or the CS group to perform the gastro-jejunal anastomosis (GJA) and the jejuno-jejunal anastomosis (JJA).

The product under investigation and the conventional suture material will be used in routine clinical practice and according to the Instructions for Use (IfU).


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing an elective, primary robotic, assisted gastric bypass surgery (with a BMI ≥40 kg/m2 or with a BMI ≥35 kg/m2) with one or more of the following comorbidities: refractory arterial hypertension, type 2 diabetes mellitus and/or proven sleep apnea) with the need to close the gastro-jejunal anastomosis (GJA) and jejuno-jejunal anastomosis (JJA).
* Age ≥18 years
* Written informed consent

Exclusion Criteria:

* Emergency surgery
* Previous gastric surgery
* History of chronic steroid use
* Pregnancy or breastfeeding
* Patients with hypersensitivity or allergy to the suture material
* Non compliance
* Participation in another randomized controlled trial
Cancer Screening; Access; Awareness; Navigation

To assess the feasibility and efficacy of community-based Colorectal Cancer (CRC) screening intervention in increasing CRC screening rates To evaluate individual-level knowledge related to CRC screening and risk factors To characterize individual -level facilitators and barriers to engaging in CRC screening and related diagnostic tests and treatment when applicable.

To address the multiple determinants of health that impact CRC screening in the South Shore community in the University of Illinois Cancer Center's catchment area by conducting an experimental intervention to test the effectiveness of Fecal immunochemical test (FIT) tests dispensed by community stakeholders (community-dispensed) versus FIT tests dispensed using standard of care procedures by a clinic dispensed FIT test return rates. This study will follow American Cancer Society (ACS) guidelines for FIT testing, with the South Shore community area assigned to the intervention group (community-dispensed). CRC screening within the Mile Square Englewood Health Center, using standard of care, will serve as our control group to use for comparison (clinic-dispensed). The intervention will include a multifaceted approach to health education and community engagement focused on CRC led by a team of trusted health champions (community leaders, a barber, a hair salon, and community health workers) in the South Shore community area.

Eligibility Criteria:
Inclusion Criteria:

* Male or female ages 45-74
* Speaks English and resides in or near the South Shore community area or utilizes the Mile Square Englewood Heath Center
* Have not had CRC screening in the previous 12 months

Exclusion Criteria:

* Adults ages \<45 or \>75
* Does not speak English
* Does not reside in or near the South Shore Community area and do not utilize Mile Square Englewood Heath Center
* Have had CRC screening in the previous 12 months
Evaluation Treatment Outcomes of Anterior Open Bite Treated by Temporary Anchorage Devices

The present study will be performed to Evaluate the treatment outcome of anterior open bite by temporary anchorage device on buccal and palatal mini screws


Eligibility Criteria:
Inclusion Criteria:

1. Patients age range 13-18 years old.
2. Patients have anterior open bite.
3. Normal healthy patient.
4. Patient have healthy oral tissues.
5. Patient have class I or II jaw relationship.
6. Patient have complete set of permanent teeth except the wisdom tooth.

Exclusion Criteria:

1. Uncooperative patient and parents.
2. patient who had undergo previous orthodontic treatment.
3. Patient with class III jaw relationship.
Cerebral Desaturation and Postoperative Dysfunction After Thoracic Surgery

The purpose of this study prospective observational study is to determine cognitive dysfunction incidence after thoracic surgery. We also evaluate evaluate the role of cerebral oxygen desaturations and hypertension as risk factors for post-operative cognitive dysfunction (POCD) in patients undergoing lung resection.


Eligibility Criteria:
Inclusion Criteria:

* patients scheduled for elective lobectomy or wedge resection via thoracotomy
* one lung ventilation (OLV duration) ≥ 45 min

Exclusion Criteria:

* previous cerebral disease,
* dementia,
* severe cognitive dysfunction
* emergency surgery
* pregnancy
* patient refusal to give consent
* inability to give consent
* age ≤18 years
* ASA ≥ IV.
The Effect of Scapular Proprioceptive Neuromuscular Facilitation Techniques on Pain and Functionality in Subacromial Impingement Syndrome

The aim of this study was to investigate the effects of scapular proprioceptive neuromuscular facilitation (PNF) techniques applied in addition to exercise therapy in patients with Subacromial impingement syndrome (SIS) on pain, pressure pain threshold (PPT), range of motion (ROM), functionality, scapular dyskinesis, active trigger points and emotional state.

32 patients between the ages of 20-60 diagnosed with SIS were included in the study.

The patients were randomly divided into two groups. The exercise group received an exercise program of 12 sessions. Scapular PNF techniques were applied to the PNF group with the same exercise program. Patients were evaluated twice; one before and one after 6 weeks of treatment; using Visual Analogue Scale (VAS) for pain, algometer for PPT, digital goniometer for range of motion (ROM), The Disabilities of Arm, Shoulder and Hand (DASH) for functional status, lateral scapular slide test (LSST) for scapular dyskinesis, Travell and Simons criteria for trigger point and Hospital Anxiety and Depression Scale (HADS) for emotional state. At the end of treatment patient satisfaction was evaluated with Global Change Scale.

Eligibility Criteria:
Inclusion Criteria:

* Aged between 20 and 60
* Diagnosed with SIS by MRI and clinical examination and a specialist physician
* Positive impingement tests (Hawkings, Neer and Jobe test) or painful motion arc (60 ° -120 °)
* Unilateral shoulder pain that has been going on for at least 3 months
* Signed voluntary consent form

Exclusion Criteria:

* Diagnosed with adhesive capsulitis or massive rotator cuff tear
* Having undergone upper limb surgery
* Presence of rheumatological systemic diseases
* Presence of Glenohumeral instability
* Having a neurological disease affecting the upper extremity
* Diagnosed with cervical radiculopathy
* Degenerative joint disorders
* Having communication problems
* Steroid injection therapy or physiotherapy in the past 6 months have been rehabilitated
Exercise and Cognition Among Stroke Survivors

This study aimed to: (1) identify a suitable cardiopulmonary exercise testing protocol for people with moderate to severe movement impairments after stroke by investigating the safety and feasibility of delivering two methods of CPET modes: treadmill with body-weight support (TBWS) and cycle ergometry (CE); and (2) explore the safety and feasibility of a delivering a 6-week exercise-based intervention or people with moderate to severe movement impairments after stroke, with a view to improve cognitive health.


Eligibility Criteria:
Inclusion Criteria:

* Have provided informed consent,
* Are aged \>18 years,
* Are more than 6 months post-stroke,
* Score 2-3 on the Functional Ambulation Category
* Can follow 1-stage commands i.e. sufficient communication/orientation for interventions in the trial.

Exclusion Criteria:

* Attending any other community exercise class/gym/walking group/rehabilitation class,
* A previous diagnosis of dementia or any other significant cognitive decline,
* Any musculoskeletal or neurophysiological disorder preventing participation in exercise,
* Have uncontrolled hypertension, atrial fibrillation, heart failure or diabetes.
* Weigh over 250lbs/113kg (due to weight restrictions on body-weight support harness on treadmill),
* Meeting any absolute or relative contraindication to exercise from American College of Sports Medicine (ACSM)

Contraindications to Exercise 2014, see below:

Absolute contraindications to exercise:

* A recent significant change in the resting ECG suggesting significant ischaemia, recent myocardial infarction (within 2 days) or other acute cardiac event
* Unstable angina
* Uncontrolled cardiac dysrhythmias causing symptoms or hemodynamic compromise
* Symptomatic severe aortic stenosis
* Uncontrolled symptomatic heart failure
* Actuate pulmonary embolus or pulmonary infarction
* Acute myocarditis or pericarditis
* Suspected or know dissecting aneurysm
* Acute systematic infection, accompanied by fever, body aches or swollen lymph glands

Relative contraindications to exercise:

* Left main coronary stenosis
* Moderate stenotic valvular heart disease
* Electrolyte abnormalities e.g. hypokalaemia, hypo-magnesia
* Severe arterial hypertensions i.e. systolic BP of \>200mmHg and/or diastolic BP of \>110mmHg at rest
* Tachydysrthythmia or bradydsrhythmia
* Hypertrophic cardiomyopathy and other forms of outflow tract obstruction
* Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
* High-degree atrioventricular block
* Ventricular aneurysm
* Uncontrolled metabolic disease e.g. diabetes, thyrotoxosis or myxedemia Chronic infectious diseases e.g. mononucleosis, hepatitis, AIDs
* Mental or physical impairment leading to inability to exercise adequately
Development of a Novel Anti-caries Chewing Gum

This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.

The goal of this project is to develop a pre-biotic chewing gum that is designed to promote a healthy oral microbiome. The gum will contain compounds that will: a) be unable to be converted to acids; b) target the cariogenic S. mutans population; c) promote the stability of a healthy environment by modulating plaque pH via base-generating compounds; d) promote tooth remineralization by increasing saliva flow and by addition of calcium phosphate.

Eligibility Criteria:
Inclusion Criteria:

* In good general health, no relevant medical history
* No dental treatment in the previous 3 months
* Willing to participate and give written informed consent

Exclusion Criteria:

* Patients undergoing fixed or removable orthodontic treatment
* Patients using removable prosthesis
* History of head and neck radiation therapy
* History of adverse reaction or allergies to xylitol or other additives
* Antibiotics use in the last four weeks
* Patients with any systemic diseases
* Xerostomia (also medication-induced)
* Smokers
* Currently using any mouth rinse
* Pregnant or breastfeeding women
A Study To Explore The Effect On Inflammatory Markers After Nasal Allergen Challenge In Subjects With Seasonal Allergic Rhinitis And The Effect Of A Single Dose Of Ibuprofen Or Fluticasone Propionate On The Allergen Response.

After a nasal allergen challenge it should be possible to measure markers of inflammation that may be useful to assess the properties of future drugs. If these markers are reproducible and impacted by the study drugs they could be useful for future drug development.


Eligibility Criteria:
Inclusion Criteria:

* Male or female subjects with seasonal allergic rhinitis (out of season).
* Sensitive to ragweed skin prick test and screening nasal allergen challenge.

Exclusion Criteria:

* Subjects with significant concomitant diseases.
* Subjects with symptoms of allergic rhinitis in 2 weeks prior to screening.
* Female subjects that are pregnant or nursing. Subjects with hypersensitivity to study drugs or allergen challenge.