cyrilzakka/clinical-trials huggingface dataset:
Narrow QRS HF Patients Assessed by ECG Belt

The purpose of this study is to quantitate electrical dyssynchrony in heart failure (HF) patients with a narrow QRS complexes (≤ 130 ms) using the ECG Belt. This is a pilot study that is designed to provide data that can be used in designing and implementing a prospective study of cardiac resynchronization therapy (CRT) in narrow QRS patients selected and optimized using the ECG Belt.


Eligibility Criteria:
Inclusion Criteria:

* Subject (or their legal guardian) must be willing to provide informed consent for their participation in the study
* Subject ≥ 18 years old

Exclusion Criteria:

* Subject has unhealed-open wounds on the torso and/or has a history of severe allergic reactions from ECG electrode gel
* Subject is enrolled in a concurrent study that could confound the results of this study
* Subject is pregnant
Bevacizumab and Photodynamic Therapy in Neovascular Age Related Macular Degeneration

The purpose of this study is to determine if of combination therapy of intravitreal bevacizumab 4 days after the application of photodynamic therapy could improve the visual outcomes of patients with neovascular age related macular degeneration.

The neovascular age related macular degeneration(AMD) is a important cause of legal blindness in adults older than 50 years. Currently the treatment is photodynamic therapy that offer stabilization and limited visual improvement after 2 years of therapy. Bevacizumab has been reported effective used as intravenous injection for AMD. But serious side effects have been reported with the use of this drug in oncologic patients. The intravitreal use has been reported in limited case reports and safety and efficacy should be determined. The purpose of this study is efficacy and safety of 2.5 mg intravitreal of bevacizumab for AMD 4 days after photodynamic therapy with verteporfin

Eligibility Criteria:
Inclusion Criteria:

55 years old neovascular Age related acular degeneration subfoveolar neovascular membrane best corrected visual acuity better than 20/200 snellen (1.0 logMAR)

Exclusion Criteria:

* Previously treated eyes glaucoma diabetes mellitus uncontrolled hypertension coronary artery disease
Regulation of Inflammatory Parameters by Telmisartan in Hypertensive Patients

A number of studies have shown that certain blood-pressure medications such as ACE-inhibitors and angiotensin-II-receptor blockers (ARB) can reduce the incidence of diabetes mellitus type 2. This protocol will evaluate whether inflammatory mechanisms mediate this effect. The investigators therefore will investigate the effect of telmisartan, a potent ARB, on lipid metabolism, glucose metabolism and inflammation in patients with the metabolic syndrome. Specific parameters will be tested before treatment and after 3 months of treatment. Placebo will be compared to 2 different doses of telmisartan per day.


Eligibility Criteria:
Inclusion Criteria:

* Abd. obesity (BMI\>25kg/m²) and waist circumference ≥95cm (men),≥80cm (women)
* Blood pressure ≥130 mmHg (systolic) and/or ≥85 mmHg (diastolic)
* Triglycerides 150-400 mg/dl
* Normal stress test
* Normal carotid ultrasound
* Normal fundoscopy

Exclusion Criteria:

* Diabetes mellitus
* Secondary cause for insulin resistance
* LDL-cholesterol \>190 mg/dl
* Atherosclerotic disease
* Blood pressure \>160 mmHg (systolic) and/or \>100 mmHg (diastolic)
* Regular alcohol consumption (\>30 g/day)
* Contraindication against telmisartan
* Antihypertensive medications
* Lipid lowering therapy
* Malignancy
* Pregnancy or Lactation
* Women without adequate contraception
Supreme LMA Use in Urgent Caesarean Section

The Supreme Laryngeal Mask Airway (SLMA) is a single use supraglottic device that provides a good seal for positive pressure ventilation and good first attempt insertion rate of 98% in low risk patients undergoing elective Caesarean section. It has a double aperture design that facilitates the introduction of an orogastric tube to aspirate gastric contents.

The primary study hypothesis is the first attempt insertion success rate of SLMA use in urgent Caesarean section.

Investigators propose a prospective cohort study to study the first attempt insertion success rate of supreme LMA in general anaesthesia for urgent caesarean section.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 to 50 years old
* American Society of Anesthesiology status 1 or 2
* Weight 40 to 75kg
* Normal airway assessment
* Term pregnancy (36 weeks or more)
* Urgent Caesarean Section

Exclusion Criteria:

* Body mass index (35 or more)
* Difficult airway (Mallampati 4 or abnormal airway assessment)
* Gastrooesophageal reflux
The Effect of Dural Puncture Epidural Block Technique on the Effectiveness and Safety of Labor Analgesia

Dural Puncture Epidural is a clinical improvement of Combined Spinal-Epidural and is widely used in Maternal.Dural Puncture Epidural Technique improves Labor Analgesia Quality And Safety By Increasing Drug Permeation.This study combines ultrasound real-time guidance technology. This technology ensures the accuracy of intervertebral space positioning and puncture success rate through operational visualization, and reduces the impact of operator proficiency on research results.

Dural Puncture Epidural is a clinical improvement of Combined Spinal-Epidural and is widely used in Maternal. The implementation step is to complete the epidural puncture, temporarily do not place a tube, puncture the dura mater with a subarachnoid anesthesia needle, but do not directly inject drugs into the subarachnoid space, and then leave an epidural catheter for administration according to epidural block. The theoretical basis is that anesthetic drugs can originally penetrate into the subarachnoid space from the epidural space through a complete spinal dura, and the puncture hole formed by spinal dura puncture facilitates this process.After injecting high volume anesthetic drugs into the epidural space, the pressure increases, and the drug penetrates from the epidural space through the puncture hole along a pressure gradient to the subarachnoid space, thereby enhancing the effect of labor analgesia.Dural Puncture Epidural also has the advantage of verifying that the epidural needle is in the middle of the epidural space again, thereby reducing the incidence of epidural catheter insertion failure or deviation to one side.This study combines ultrasound real-time guidance technology. This technology ensures the accuracy of intervertebral space positioning and puncture success rate through operational visualization, and reduces the impact of operator proficiency on research results.

Eligibility Criteria:
Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) Class I or II;
2. Single healthy pregnancy;
3. Head showing first;
4. 37 to 41 weeks;
5. The labor process is active, and the cervix dilates\<5cm;
6. Require epidural labor analgesia;
7. Volunteer to participate in this study and sign an informed consent form.

Exclusion Criteria:

1. Presence of pregnancy diseases, such as pregnancy hypertension, pre eclampsia, pregnancy diabetes;
2. Contraindications to intraspinal analgesia: 1) Central nervous system diseases. 2) Infection or septicemia at the puncture site. 3) Coagulation dysfunction;
3. Known cases of fetal malformation or increased risk of cesarean section, such as a history of uterine rupture;
4. Persons with a history of mental illness, hysteria, epilepsy, etc. who cannot cooperate.
5. Patients with long-term use of opioids, steroids, and chronic pain.
Health Status and Quality of Life in the Elderly

The study is designed to investigate the effect of AMP886 (alpha-tocotrienol) on health status and quality of life measures, cognitive functioning, oxidative stress, inflammation markers and other symptoms effects on skin, sleep and vision in the elderly.


Eligibility Criteria:
Inclusion Criteria:

* Males and females 65-85 years old
* ECOG Performance score 0 to 1
* Body mass index 22-30 kg/m2
* Body weight \>60 kg
* Habit to consume standard breakfast like toast, bread, butter/margarine, eggs, bacon, cereals with milk
* Comply with protocol and likely to be compliant with prescribed product

Exclusion Criteria:

* Renal insufficiency or failure at screening
* Current or previous positive documented history of any chronic inflammatory state including chronic infection, arthritis, or collagen vascular disorder.
* Comorbid medical conditions
* Use of prescription medication for chronic conditions
* Use of hormone replacement therapy (with the exception of levothyroxine)
* Uncontrolled hypertension
* Use of hemostatic agents
* Hemorrhagic disorder and/or coagulation disorder
* Clinically important bleeding within 90 days prior to screening visit
* Fat malabsorption syndromes
* Constipation and/or abdominal pain/discomfort that require dietary supplements or medical therapy
* History of smoking within 1 year prior to visit 1.
A Quality Rating Scale for Patients in Complex Situations and Their Caregivers

Identify and analyze in the exercise groups coordinated (GECO) the effects of coordination arrangements between professionals on the transformation of modes of exercise of professional care, and on the experience of patients / users and that of caregivers, particularly on dimensions constituted that the quality of care in order to build a coordinated exercise structures rating scale primary care on the basis of criteria suggested by patients


Eligibility Criteria:
Inclusion Criteria:

* For Professionals:
* Medical or paramedical professionals working in the exercise coordinated groups (GECO) initially defined
* Professionals who made his non_opposition
* For patients and family caregivers:
* Binomials patients / caregivers over the age of 18.
* Binomials patients / caregivers who formulated his non_opposition
* Patients experiencing complex care (multi-morbid and chronic)

Exclusion Criteria:

* Refusal of a participant (Professionals / Patients / caregivers) to respond to inquiries
ESP Block on Patient Outcomes in Patients With Liver Tumor Undergoing Radiofrequency Ablation

To evaluate the ability of Erector spina Plane Block decrease postoperative pain and analgesia requirements in patients undergoing percutaneous Radiofrequency ablation of Hepatocellular Carcinomas.

Erector spina Plane Block is performed with guided ultrasound at T8 transverse process level lead to adequate intraprocedural and postoperative analgesia, in percutaneous Radiofrequency ablation of Hepatocellular Carcinomas.

Eligibility Criteria:
Inclusion Criteria:

* ASA I-II patients

Exclusion Criteria:

* history of allergy to the study medication
* refused to participate
Type I Collagen Fragments in the GCF and Saliva During OTM

Investigate the levels of type I Collagen fragments ICTP and CTX in GCF and saliva during initial leveling and alignment of the teeth in a sample of adolescents undergoing orthodontic treatment.

Type I Collagen fragments ICTP (cross-linked carboxyterminal telopeptide of type 1 collagen) and CTX (C-terminal cross-linked telopeptide of type I collagen) are specific bone resorption biomarkers released in the circulation after osteoclastic bone resorption and collagen degradation and were found to be released in gingival crevicular fluid (GCF) and saliva during metabolic bone diseases and active periodontitis. So the aim of the study is to investigate the levels of ICTP and CTX in GCF and saliva during initial leveling and alignment of the teeth in a sample of adolescents undergoing orthodontic treatment.

Eligibility Criteria:
Inclusion Criteria:

* The age ranges from 13-18 years old.
* Good oral hygiene.
* Clinical gingival health on the intact periodontium.
* Permanent dentition.
* Moderate crowding.
* Non-extraction treatment plan. If extraction of teeth is required, the treatment plan should allow for postponing extraction after sample collection.

Exclusion Criteria:

* Systemic diseases associated with loss of periodontal supporting tissues.
* Metabolic bone diseases and systemic medications affecting bone metabolism.
* Craniofacial anomalies such as cleft lip and/or palate.
* Xerostomia.
* Tobacco-related habits such as smoking, tobacco chewing, etc.
Public Survey on Breath Testing for Health and Disease

A brief survey for the public to determine interest in health surveillance and disease detection

There are numerous barriers and favourable conditions that affect the acceptability of a screening test for cancer. Such factors have been investigated in the context of some of the current screening programs. Through this survey the investigators want to increase researcher awareness of these factors with the hope that this information will aid policy makers and guide future research.

There has been widening public interest in general health-surveillance in addition to disease detection. Breath testing has the potential to be a one-for-all non-invasive test to detect health domains. Through this survey, the investigators wish to understand public opinions about breath testing for health.

This survey consists of questions aiming to gather views on non-invasive testing for health and disease.

Eligibility Criteria:
Inclusion Criteria:

* Member of the public above the age of 18

Exclusion Criteria:

* Member of the public below the age of 18
Dose-dependent Effects of Blueberry Polyphenols on Endothelial Function in Healthy Individuals

The purpose of this study is to assess the impact of acute blueberry polyphenol intake on endothelial function of healthy volunteers. Specifically, the investigators plan to perform a randomised, double blind, cross-over human intervention trial using a blueberry drink to investigate the dose-dependent effects of blueberry polyphenols on blood vessel function using Flow mediated dilation (FMD) to measure endothelial function. The study will not only measure the acute effects of flavonoid ingestion on vascular reactivity but will also assess plasma polyphenol metabolite levels.


Eligibility Criteria:
Inclusion Criteria:

* Male
* 18-40 years
* Healthy
* signed consent form

Exclusion Criteria:

* Blood pressure \> 140/90 mmHg
* Had suffered a myocardial infarction or stroke
* Suffers from any blood-clotting disorder
* Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
* Any dietary restrictions or on a weight reducing diet
* Allergies or intolerances to any foods
* Smoker
* Heavy drinker (\>21 units per week)
* On any lipid-modifying medication
* On any blood pressure lowering medication
* On any medication affecting blood clotting
* Taking high dose fish oil supplements (greater then 1 g EPA and DHA per day) or high doses of antioxidant vitamins (greater then 800 μg vitamin A, 60 mg vitamin C, 10 mg vitamin E or 400 μg beta carotene)
* Taking probiotics, prebiotics, synbiotics, antibiotics or anti-inflammatory or blood lowering medication within a 2-month period prior to the study
* Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
* Undertakes strenuous exercise \> 4 times per week for \> 1 hour per session
* Haemoglobin levels below reference range provided by the Royal Berkshire Hospital
Intravoxel Incoherent Motion Prognostic Value in the Initial Evaluation of Patients With Acute Ischemic Strokes Using 3 Tesla Magnetic Resonance Imaging

Ischemic strokes are the first cause of handicap in adult people, the second cause of dementia and the third cause of death in France. Brain Magnetic Resonance (MR) initial assessment is mandatory to get the right diagnosis, to exclude hemorrhagic lesions and to determine the best treatment.

The conventional diffusion weighted imaging sequence is used to establish the diagnosis and to estimate the volume of ischemic lesions. The perfusion weighted imaging sequences are also used to assess the diffusion-perfusion mismatch which is supposed to be the ischemic penumbra corresponding to territories that could be saved with appropriate treatments.

IntraVoxel Incoherent Motion (IVIM) is a multi-b diffusion sequence which allows to extract four quantitative variables (D, D\*, f, ADC) related to the true molecular diffusion and correlated to the microvascular perfusion.

It's a quick sequence with no need of contrast injection and allowing a perfect coregistration with the true diffusion. It has been validated in many pathologies but not in acute strokes.

The feasibility of this sequence in acute ischemic strokes has already been assessed with interesting results.

The study aims to assess the correlation between the quantitative values of IVIM at initial MR exam and the modified Rankin Scale (mRS) score 3 months after an acute ischemic stroke.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients
* Admitted for an acute ischemic stroke
* Affiliated to a Social Security scheme

Exclusion Criteria:

* Absolute contraindications to MRI
* Pregnant or breastfeeding woman
Electromagnetic Navigation System Versus Freehand Technique in Total Hip Arthroplasty

A prospective randomized study comparing accuracy and precision of acetabular component placement in total hip arthroplasty with use of novel electromagnetic navigation system versus freehand technique.

Patients with hip arthritis, who are to be treated with total hip arthroplasty will be randomized in two groups. Patents allocated to study group will get their acetabular components implanted with the help of electromagnetic navigation system. Patients allocated to the control group will get their acetabular components implanted with freehand technique. Accuracy and precision of implanted acetabular components will be assessed on images obtained by postoperative computed tomography. Postoperative inclination and anteversion angles of acetabular components will be measured by the independent technician. Results will be statistically analyzed and compared.

Eligibility Criteria:
Inclusion Criteria:

* age above 18 years
* unilateral surgery
* osteoarthritis of the hip
* no previous surgery on the affected hip
* implantation of the same acetabular component through the same approach
* signed informed consent

Exclusion Criteria:

* age under 18 years
* unwilling to participate
* prior surgery on affected hip
Recombinant Human Endostatin in Combination With XELOX Therapy in Patient With Advanced Colorectal Cancer.

To study safety and efficacy of intravenous pump of recombinant human endostatin combined with XELOX-treated and also investigate the potential value of CECs level for the prediction of PD and outcomes in patients with advanced colorectal cancer.


Eligibility Criteria:
Inclusion Criteria:

* Clear pathology diagnosis of stage for the Ⅳ period of advanced colorectal cancer.
* There are at least 1 imaging examinations according to the standard of RECIST（the longest diameter is at least 10mm with spiral CT and 20mm with ordinary CT）.
* Male or female , age 18～75
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* The patients had to have a life expectancy of at least 3 months.
* A white blood count (WBC) greater than 3000/mm3, platelets greater than 100 000/mm3, and normal coagulation values.
* Aspartate aminotransferase (AST) and adenosine triphosphate (ALT) values were to be less than 2.5 times the upper limit of normal;a bilirubin level of less than 25 lmol/l；a creatinine value less than 130 lmol/l.
* Informed consent was obtained from all patients.

Exclusion Criteria:

* Patients having a brain tumor or brain metastases, a bleeding disorder, receiving anti-coagulant therapy.
* a history of myocardial infarction or angina pectoris in the last 6 months or uncontrolled congestive heart failure, having an active infection or receiving radio- or chemotherapy within 4 weeks before study.
* patients with uncontrolled serious medical or psychiatric illness or having any other condition that was likely to interfere with regular follow-up.
Impact of a Multidisciplinary Consultation Program on Drug Adherence in First Oral Anticancer Treatment

Oncology management has changed dramatically over the last decade with the approval and rapid adoption of newly targeted oral oncology medications. The movement to oral oncology medications has altered the balance of risks and adverse effects (AEs) in the treatment of cancer care. These treatments are associated with a different constellation of AEs and drug interactions. Patients receiving treatment with oral anticancer treatment (OAT) encounter several barriers to adherence, which may include limited access to specialty medications, severe adverse effects, complex medication regimens, and special handling precautions. Medication nonadherence not only reduces the efficacy of drug therapy but also has the potential to increase healthcare expenditures due to disease-related hospitalizations. The purpose of this study is to evaluate the drug adherence in cancer patients, using the medication possession ratio (MPR), before and after the implementation of a multidisciplinary consultation program (MCP), on initiation of OAT.


Eligibility Criteria:
Inclusion Criteria:

* French speaking patients with a newly diagnosed or relapsed cancer, regardless of location and introduction of oral anticancer treatment

Exclusion Criteria:

* patients treated with hormone therapy only
* Patient with severe psychiatric disorders
* patient who does not speak the French language
The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease（AURORA）

The deleterious effects of hyperuricemia (HUA) on cardiovascular disease (CVD) were well established. Aspirin is the most commonly prescribed antiplatelet agent for primary or secondary prophylaxis of CVD. Only a few short-term studies in the elderly suggested low-dose aspirin, e.g., 75-100 mg/day, increases serum urate by reducing urinary uric acid excretion. However, monitoring of renal function is currently not recommended. Little is known about the long-term effect of low dose aspirin on uric acid. The principal aim of this prospective cohort study therefore is to evaluate the renal effects of long-term aspirin (100 mg/d) administration in Chinese patients with coronary artery disease or other CVDs.


Eligibility Criteria:
Inclusion Criteria:

1. Patients with coronary artery disease (CAD) who underwent (Percutaneous Transluminal Coronary Intervention) PCI therapy, documenting angiographically at least one vessel stenosis ≥50% among major coronary arteries (left main, left anterior descending, left circumflex or right coronary artery) , manifesting clinically as latent CAD, stable CAD, unstable CAD, and acute myocardial infarction.
2. Patients with CAD without PCI therapy. They document angiographically at least one vessel stenosis ≥50% among major coronary arteries (left main, left anterior descending, left circumflex or right coronary artery) , and classified clinically as latent CAD, stable CAD, unstable CAD.
3. Patients without CAD who needs antiplatelet therapy for prophylaxis of ASCVD, documenting angiographically no vessel stenosis ≥50% among any of major coronary arteries (left main, left anterior descending, left circumflex or right coronary artery).

Exclusion Criteria:

1. Patients with severe conditions with life expectancy less than 12 months.
2. Patients with malignant tumor.
3. Severe Kidney disease: patients with acute kidney injury, nephritic syndrome, renal replacement therapy, kidney transplant or eGFR \<30 mL/min/1.73 m2.
4. Contraindicated to antiplatelet therapy because of acute bleeding.
5. Patients who formerly administrated aspirin for at least one week or withdrawal of aspirin less than one month before enrollment.
6. Patients who formerly administrated UA lowering agents at least one month before enrollment.
7. Patients who formerly administrated, stopped or titrated doses of any of the following drugs at least one month before enrollment: losartan, irbesartan, fenofibrate, thiazide and loop diuretics.
8. Patients who administrated ticagrelor as antiplatelet agent one month before enrollment or since then.

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