cyrilzakka/clinical-trials huggingface dataset:
The Effects of Cervical Sensorimotor Control Challenges on Gait Patterns, Cervical Sensorimotor Control During Dynamic Tasks

To investigate the influence of cervical SMC challenges during gait-related dynamic tasks on all task performance and symptoms in patients with CNP.

The goal of this observational study is to learn about the immediate effects of cervical sensorimotor challenges during gait-related dynamic tasks on all task performance and symptoms in patients with CNP .

The main question it aims to answer is:

Does adding sensorimotor challenges in chronic neck pain patient will affect balance and gait performance?

Eligibility Criteria:
Inclusion Criteria:

* Healthy asymptomatic adults will not have any complaints of current pain and impairments of neuromusculoskeletal systems within the last 6 months.
* For patients with CNP

  * Pain was unilateral or bilateral between the superior nuchal line and 1st thoracic vertebra
  * Neck pain persisting for 3 months and above
  * Average pain intensity of last pain episode was between 2 and 8 based on the numeric rating scale (NRS).

Exclusion criteria:

◾For patients with CNP and healthy asymptomatic adults

* Acute or the first onset of neck pain
* Traumatic cause of pain
* Previous fracture or surgery of the spine
* Diagnosed cardiopulmonary diseases, for example, chronic obstructive pulmonary disease, pulmonary tuberculosis, asthma, chronic bronchitis, pulmonary emphysema
* Diagnosed gastrointestinal and abdominal conditions which may interfere daily activities within the past 6 months
* Medical conditions that may affect balance and study procedures (e.g. neurological diseases, vestibular disorders, malignant tumors)
* Metabolic diseases such as anemia and diabetes
* Smoking, plan to pregnant or in pregnancy
* Psychological disorders (affect questionnaire responses)
* Unable to walk independently
* Corrected visual abnormalities or individuals unable to wear contact lenses for vision correction due to the potential interference of wearing VR head-mounted display with glasses.
Exercise Versus Corticosteroid Randomized Clinical Trial for Plantar Fasciitis

Chronic plantar fasciopathy is a painful condition common in the workplace, particularly for those workers required to stand for long periods of time, and is typically associated with point tenderness at heel and arch of the foot. This clinical trial will investigate the effectiveness of an innovative multi-element exercise program versus the standard of care for plantar fasciopathy. The observation period will be 12-weeks. Outcomes are determined through questionnaire and ultrasound imaging. Workers with long-standing plantar fasciopathy who must stand for prolonged periods of time (i.e. \> 6 hours) during their workday will be invited to participate in this study. After ensuring eligibility, each subject will be randomly assigned to either the intervention group who will receive a multi-element exercise program, or the control group who will receive a cortisone injection followed by a stretching program for their calf-muscles (standard of care). The treatment length for both groups will be 12-weeks.


Eligibility Criteria:
Inclusion Criteria:

* Adult workers (men and women) between the ages of 19 and 60
* Workers required to stand for 6 hours or more in their respective workplaces
* Diagnosed with plantar fasciopathy (plantar fasciitis). All diagnoses will be made by a physiotherapist based on the presentation of palpable pain at or around the plantar medial heel, in addition to pain during weight-bearing activities and the presence of morning pain.
* Only individuals with pain for longer than 12 months will be included.

Exclusion Criteria:

* A history of surgery to their plantar fascia
* Osteoarthritis or other degenerative musculoskeletal disorders affecting the lower extremity
* Individuals who have received corticosteroid injections into their affected plantar fascia at any time in the past will be excluded.
Ethical Attitude and Humanistic Acting Skills of Intensive Care Nurses

Today, rapidly developing technology and changing treatment and care conditions increase the tendency towards ethical values both as an intellectual concept and as a moral guide. The nursing profession, which focuses on people in ethical terms, is also performed by people. This situation brings with it many ethical dilemmas in areas where health care services are provided. In ICUs, long and critical treatments of patients, differences of opinion between the medical team and the institution, non-compliance with patient rights, difficulties in terminal patient care, procedures performed without the patient\&#39;s consent, distribution of limited medical resources, unethical attitudes and attitudes of nurse colleagues, Many issues such as long-term exposure to stressors and constant alarm sounds can cause mental distress and negative emotions in intensive care nurses. One of the effective ways to increase the quality of care provided by nurses is humanistic practice ability. The presence of humanistic practice ability provides more realistic, human-centered nursing care, improves the quality of life of patients, and also positively affects health expenditures.

One of the effective ways to increase the quality of care provided by nurses is humanistic practice ability. The presence of humanistic practice ability provides more realistic, human-centered nursing care, improves the quality of life of patients, and also positively affects health expenditures. The humanist approach is increasing its importance day by day in planning individual care, evaluating the outcomes of care practices, and health-promoting information programs. In this context, it is of great importance to develop the humanist practice skills, humanist nursing spirit, humanist clinical practices and humanist nursing education of nurses who are actively involved in ICUs, as in all areas of care practice. In developing nurses\&#39; humanistic nursing behaviors, their level of knowledge and behavioral skills should first be revealed.

When the literature was examined, it was seen that there were studies examining the extent to which nurses experienced ethical problems and dilemmas during caregiving, their attitudes, and ethical decision-making processes. While studies on nurses\&#39; ethical decision-making processes are important, it is thought that studies measuring their level of humanistic behavior will also contribute to nursing care. This research aims to show the effect of intensive care nurses\&#39; ethical attitude levels on their ability to act humanistically. The research is original in that it combines ethical attitudes and humanistic behavior. It is anticipated that the research will contribute to nursing care and the knowledge base of the nursing profession.

Eligibility Criteria:
Inclusion Criteria:

* Becoming an intensive care nurse
* Volunteering to participate in the study

Exclusion Criteria:

* Not being an intensive care nurse
* Not volunteering to participate in the study
Effect Study of a Theory-Based Internet Intervention on Safe-Sex Practices

The purpose of this study is to examine the efficacy of a theory based, online tailored intervention on stimulating safe-sex practices among men who have sex with men (MSM). Our hypothesis was that a tailored internet intervention would be more effective in stimulating safe-sex practices of gay men than a non-tailored internet intervention when compared to a waiting-list control group.

Relationships are a high-risk setting for HIV-infection. This trial aimed at testing the efficacy of an online theory-based tailored intervention for preparing single MSM to practice safe sex with future steady partners-labeling it the 'cognitive vaccine approach'.

The target was the promotion of negotiated safety (NS): steady partners testing for HIV and reaching agreements to either be monogamous or to only have safe sex outside the relationship in order to have safe unprotected anal intercourse with each other. The intervention content was based on the information, motivation, behavioral-skills model and the intervention was tailored according to knowledge, motivation, and skill-related deficiencies of each participant. Condom use was promoted as the default alternative for NS. Using an online randomized controlled trial we examined the effects of a tailored versus non-tailored version of the intervention. The cognitive effect (i.e. response efficacy, intentions, and perceived behavioral control (PBC) was measured directly after the intervention and, after 6-months, the behavioral effect (i.e. NS and condom use) via e-mail follow-up.

Eligibility Criteria:
Inclusion Criteria:

* Men who have sex with men of all ages, HIV-negative or of unknown serostatus, single, and open to a steady relationship with a man in the future
The Effect of Cold Exposure on Energy Expenditure

Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health. Cold acclimation may alter cold-induced thermogenesis due to changes in (non)shivering thermogenesis and blood flow. The main aim of this research is to compare the energy expenditure responses, during a standardised cold stress (\~ 9°C air temperature, maximum 1 hour), of Siberian adults with Western European adults. The subjects will be individually matched for age, sex, body mass and height. It was hypothesised that cold-induced thermogenesis will be reduced in the Siberian population.


Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent
* Western European origin or of Siberian origin
* BMI between 18.5 and 35 kg/m2
* Generally healthy (determined by dependent physician)

Exclusion Criteria:

* Smoking
* Active, uncontrolled cardiovascular disease or cancer
* Raynaud's disease
* Participation in another biomedical study within 1 month before the first study
* Cold-acclimated (Western European group), such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
* Medication use known to hamper subject's safety during study procedures
* Abuse of alcohol or drugs
Medical Termination of Pregnancy : Evaluation of Patients' Practices and Feelings in Brest Hospital

This study evaluate the feelings of patients about a medical termination of pregnancy that they experienced in Brest Hospital. Patients responded to an online questionnaire assessing their feelings at each stage of the medical termination process. Their answers were associated with their medical data.


Eligibility Criteria:
Inclusion Criteria:

* Patient having experienced a medical termination of pregnancy in Brest Hospital
* Medical termination of pregnancy after 14 weeks
* Induction for natural delivery
* No opposition

Exclusion Criteria:

* Medical termination of pregnancy before 14 weeks
* Selective termination of pregnancy (multiple pregnancy)
* Caesarean
* Patient not speaking french
* Patient's refusal
Website for Adolescents About Pediatric Clinical Trials

The goal of this study is to evaluate the effectiveness of DigiKnowIt News: Teen with parent-adolescent pairs.

Parent-adolescent pairs (N=180) will be recruited to participate in a randomized controlled trial. Parent consent and parent permission and youth assent will be sought. Participant pairs will be randomized into one of two study arms: intervention and wait-list control. All participants will complete a web-based pre-test questionnaire. Youth and parents in the intervention group will then receive access to DigiKnowIt News: Teen for one week. Approximately one week after completing the pre-test questionnaire, all participants will complete a web-based post-test questionnaire (the post-test for the intervention group will include Consumer Satisfaction Questions). Youth and parents in the wait-list control group will then receive access to DigiKnowIt News: Teen for one week. After one week, they will be asked to complete a Consumer Satisfaction Questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* Adult participant is a parent or legal guardian of adolescent participant;
* Adolescent participant is within the ages of 12-17 years;
* Parent-adolescent pair has access to a computer or tablet with internet connection
* Parent-adolescent pair is fluent in English

Exclusion Criteria:

* Adolescent participant has previously participated in a clinical trial after kindergarten.
Elective Internal Mammary Node Irradiation in Women With Node-positive Breast Cancer

The aim of this study is to find out whether the inclusion of internal mammary node irradiation in regional nodal irradiation improves outcomes in women with node-positive breast cancer.

This is a multicenter, prospective, randomized phase 3 trial. Patients with node-positive breast cancer without distant metastases were included. All patients underwent breast conservation surgery or mastectomy with axillary lymph node dissection before irradiation. Patients underwent regional nodal irradiation along with breast or chest wall irradiation and randomly allocated to either IMNI or no IMNI.

Eligibility Criteria:
Inclusion Criteria:

1. Women with histologically confirmed node-positive breast cancer who had undergone modified radical mastectomy or breast-conserving surgery and axillary dissection with ≥8 nodes removed.

Exclusion Criteria:

1. Neoadjuvant chemotherapy
2. Bilateral breast cancer
3. Distant metastasis
4. History of other malignancy
5. Involvement of supraclavicular nodes or internal mammary nodes at diagnosis
Study of the Guardian System on Motor Recovery and Impact on Length of Stay in Ischemic Stroke Patients

This is a non-blinded randomized study that will investigate whether the use of a novel, non-invasive perfusion enhancement system (The Guardian System) impacts motor recovery and hospital length of stay in acute ischemic stroke patients.

This clinical research study is a prospective, non-blinded randomized clinical trial. The study protocol and consent form have been approved by the IRB at the Study Institution. As per the study design, consecutive adult patients admitted to the neuro-intensive care unit, with acute ischemic stroke, meeting the inclusion and exclusion criteria will be consented and enrolled in the study. Both the Study and Control groups will receive the standard of care for ischemic stroke according to the hospitals' protocols, policies and procedures. After obtaining informed consent, patients in the study arm will have the non-invasive perfusion enhancement system (The Guardian System) placed on their beds and chairs. The inflatable surfaces (the enhancers) will be placed directly on the mattress and chair under the fitted sheet and bed linens. They will be secured with a non-porous, non-slip silicone attacher. An adaptive pressure controller will be attached to the perfusion enhancer through a connector set. The adaptive pressure controller will be secured to the bed foot board or side rail and have the ability to be secured to an Intravenous pole as necessary. Specific data points for each patient in the Experimental group will be entered into the Controller: they include the patient's weight in kilograms and the patient's position (bed or chair).

This study seeks to evaluate the device's effect on motor recovery and length of stay in a homogeneous ischemic stroke population that will be randomized for use of the novel non-invasive perfusion enhancement device from admission to discharge.

Eligibility Criteria:
Inclusion Criteria:

* Only Acute Ischemic Stroke Patients
* Baseline Modified Rankin Score of less than or equal to 0-2
* Remains hemiplegic (left or right) with motor component score on National Institute of Stroke Health Scale of 2-4 on arm/leg with or without thrombectomy/tissue plasminogen activator
* Insured (Medicare or private)

Exclusion Criteria:

* Dementia or Alzheimer Diagnosis
* Concurrent hemodialysis
* Obesity with Body Mass Index greater than 33
* Baseline Modified Rankin Score of 3 to 5
* Patients requiring ventilator support of greater than 2 days
* Peripheral neuropathy
* Concurrent deep vein thrombosis or venous thromboembolism
* Presence of concurrent pre-existing pressure injury
* Prolonged inconsistent use of perfusion therapy defined as two or more consecutive hours off of the perfusion enhancement device
Rumination Focus Cognitive Behavior Therapy

1. To investigate the efficacy and acceptability of a guided internet-delivered transdiagnostic intervention targeting repetitive negative thinking for individuals with elevated levels of depression and generalized anxiety disorder (mild to moderate clinical symptoms) vs a wait-list control group (WLCG).
2. To investigate the hypothesized mechanism of change: Repetitive negative thinking is reduced first, and consequently the clinical symptoms (depression and/or anxiety) decrease.

The effectiveness of a Rumination Focused Cognitive-Behavioral Treatment (RF-CBT) will be compared with a wait list control group using a randomized control trial (RCT) design in a culture where this has not been tested before. The treatment approach was design to specifically target repetitive negative thinking (e.g., rumination and worries). Specifically, the treatment involves first a functional analysis design to help participants identify when rumination starts, distinguish between helpful versus unhelpful repetitive thinking, and learn more functional responses, and experiential and imagery exercises design to help them shift their thought processing towards concreteness, absorption and compassion. The main goal of the study is to test the effectiveness of this transdiagnostic approach in reducing symptom of depression and anxiety.

Eligibility Criteria:
Inclusion Criteria:

1. be fluent in Romanian,
2. be at least 18 years of age,
3. display elevated levels of worry and/or rumination (e.g., at least one self-report score above the following cut-offs: Penn State Worry Questionnaire Total score \> 50 and/or Rumination Response Scale - Brooding sub-scale ≥ 10)
4. have at least a clinical diagnosis of major depressive disorder/dysthymia, and/or generalized anxiety disorder, and/or social anxiety disorder, and/or panic disorder, or any combination of these conditions on Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders (SCID-I)

Exclusion Criteria:

1. suicidal plans,
2. changes in the dosage if psychotropic medication during the last month (if present),
3. have bipolar disorder or psychosis (according to medication status)
4. have an alcohol/substance abuse and/or dependence disorder
5. currently take part in other psychological treatment,
6. obvious obstacle to participation (i.e., no current Internet access, long travel plans during the treatment period etc.);
7. have a primary diagnostic of Post-Traumatic Stress Disorder and/or Obsessive Compulsive Disorder
Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder

The purpose of this study is to obtain data investigating the safety and efficacy of eszopiclone for the treatment of post-traumatic stress disorder (PTSD)-related sleep disturbance and the impact of improved sleep with eszopiclone treatment on neuroendocrine correlates of PTSD. The investigators hypothesize that eszopiclone will be significantly more effective than placebo and well tolerated for PTSD-related sleep disturbance, improvement in sleep will be associated with improvement in overall PTSD symptoms, and patients with PTSD-related sleep disturbances will have abnormal levels of stress hormones.

Post-traumatic stress disorder (PTSD) is characterized by three symptom groupings: re-experiencing symptoms including flashbacks, nightmares, and intrusive memories; physiological hyperarousal; and avoidance symptoms. Of the three major categories of symptoms in PTSD listed by the Diagnostic and Statistical Manual of Mental Disorders, sleep-related problems are listed in two of them: difficulty falling asleep is considered an aspect of hyperarousal symptoms, and nightmares are a type of re-experiencing symptom. Both are found commonly in PTSD. Little is known about the relationship of neuroendocrine dysregulation in PTSD and sleep disturbance. It is possible that successful treatment of sleep disturbance in PTSD may alter an abnormal stress hormone pattern. The novel cyclopyrrolone hypnotic eszopiclone thus presents an intriguing opportunity to examine the treatment of sleep disturbances and nightmares in PTSD. This study will determine the safety, efficacy and impact on neuroendocrine parameters of eszopiclone compared to placebo for sleep disturbance and overall PTSD symptoms in individuals with PTSD and reported sleep disturbance.

Eligibility Criteria:
Inclusion Criteria:

* Male or female outpatients 18-64 years of age with a primary diagnosis of PTSD as defined by DSM-IV criteria with associated sleep disturbance

Exclusion Criteria:

* Pregnant women, lactating women, and women of childbearing potential who are not using medically accepted forms of contraception.
* Concurrent use of other psychotropic medications, other than antidepressants at stable dose for at least 4 weeks prior to randomization
* Serious medical illness or instability
* Seizure disorders with the exception of a history of febrile seizures if they occurred during childhood
* Concurrent psychotherapy initiated within one month of randomization or ongoing psychotherapy of any duration directed specifically toward treatment of PTSD and/or sleep disturbance
* Diagnosis of schizophrenia, mental retardation, OCD, organic medical disorders or bipolar disorder, eating disorders in the past 6 months, alcohol or substance abuse in the past 3 months, or dependence within the past 6 months.
* Patients with significant suicidal ideation or who have enacted suicidal behaviors within 6 months prior to intake
Assessment of the Efficacy of Microosteoperforations Versus Injectable Platelet-rich Fibrin During Orthodontic Leveling and Alignment of Mandibular Incisors

The aim of this prospective clinical study will be to compare the efficacy of micro osteoperforations versus injectable platelet-rich fibrin during orthodontic leveling and alignment of mandibular incisors.


Eligibility Criteria:
Inclusion Criteria:

1. An age range from 15 to 25 years.
2. Participants who had a full set of permanent dentitions excluding the third molar.
3. Participants who had moderate crowding in the mandibular arch according to Little's irregularity index that necessitates non-extraction treatment in the mandibular arch.
4. Normal vertical facial proportions.
5. Participants who had good oral hygiene and no periodontal disease.
6. No systemic diseases or regular medication that could interfere and/or affect orthodontic teeth movement.
7. No evidence of craniofacial anomalies, such as clef lip and palate or previous history of trauma, bruxism, or parafunction.
8. No tooth size, shape, or root abnormalities visible on patient's radiographic records.

Exclusion Criteria:

1. Previous orthodontic treatment.
2. Any skeletal dysplasia or craniofacial malformation.
3. Retained primary or missing permanent teeth in the anterior area, and any kind of tooth/root shape anomaly or history of trauma affecting the incisors.
4. Systemic diseases or regular use of medications that could interfere with OTM.
5. Patients with root resorption, impacted canines, or dental anomalies.
6. Poor oral hygiene and uncontrolled periodontal diseases.