cyrilzakka/clinical-trials huggingface dataset:
Kinesiotaping for Normalizing Scapular Dyskinesis

The 3-dimensional position and orientation of the scapula as well as muscle activation of upper trapezius (UT), lower trapezius (LT) and serratus anterior (SA) of asymptomatic dyskinetic sportspeole will be recorded during shoulder flexion and shoulder abduction, in loaded and unloaded conditions. Participants will be assessed in standard condition and with two differents kinesiotaping techniques.

About 20 dyskinetic asymptomatic people will be involved in the study. The objective will be to compare two different kinesiotaping techniques in normalizing scapular kinematics.

Tridimensional-movement of the scapula and EMG activity of periscapular muscles will be evaluated doing flexion (sagittal plane) and abduction (frontal plane) movements.

EMG acquisitions :

The electromyographic (EMG) signals are collected with Trigno Standard and Trigno Mini wireless sensors (Delsys, Boston, MA, USA) using silver-contact bipolar bar electrodes with ﬁxed 10 mm inter-electrode spacing \[49\]. Three of the main scapular stabilizing muscles of the shoulder are investigated: upper trapezius, lower trapezius and serratus anterior. Electrodes are placed on the dyskinetic side. In case of bilateral scapular dyskinesis, electrodes are placed on the side where the most important dysfunction was observed. Data are acquired at a sample frequency of 1000 Hz.

Tridimensionnal assessment:

Scapular kinematics is assessed using a three-dimensional motion analysis system, an optoelectronic system based on active markers (Codamotion, Charnwood Dynamic, UK). For that purpose, four Codamotion CX1 units are used, at a sampling of 100 Hz. Fifteen active markers were placed on the skin of the subject on the same side as EMG electrodes: 4 on the thorax, 6 on the scapula, 4 on the arm and 1 on the acromio-clavicular joint.

Procedure :

* Warm up : 2x10 shoulder internal and external rotations
* Maximum voluntary isometric contraction (MVIC)
* 10 mouvements of abduction (frontal plane) + 10 mouvements of flexion (sagittal plane), with and without load in each condition (without kinesiotaping, with a first kinesiotaping technique and with a second kinesiotaping technique). The order of the different conditions will be randomised.

Eligibility Criteria:
Inclusion Criteria:

* unilateral or bilateral scapular dyskinesis (visual evaluation, "yes-no method")
* scapular downward rotation at rest

Exclusion Criteria:

* asymmetry of length of lower limbs
* scoliosis or dorsal hyperkyphosis shoulder surgical history
* shoulder pain, shoulder injury (muscular, osseous, ligamentary, tendinous) or positive tendinous and impingement tests (Jobe, Patte 0°, Patte 90°, Lift off Test, Palm-up Test).
VIA Family 4 Year Follow-up of a Family-based Preventive Intervention

This study aims to investigate the long-term effects (2.5 years after post-intervention) of a preventive family-based intervention (VIA Family) compared with treatment as usual (TAU) for children of parents with a severe mental illness.

Background:

Children of parents with a mental illness have an increased lifetime risk of developing a mental illness themselves. Preventive interventions for families with children with high familial risk can potentially disrupt the transgenerational transmission.

The current study is a follow-up study of a trial investigating the effect of the preventive intervention: the VIA Family trial.

The VIA Family trial investigated the superiority of a preventive family-based intervention, VIA Family, compared with treatment as usual (TAU) in improving children's, parents' and families' functioning and well-being. Eligible families had at least one parent with a lifetime severe mental illness diagnosis ( i.e. recurrent major or moderate depression, bipolar disorder, or schizophrenia spectrum disorder), at least one child between the ages of 6-12 years and lived within the Frederiksberg or Copenhagen (Denmark). The trial had a randomized, two-armed, parallel and controlled design. The participating families were randomly assigned to both groups with an allocation ratio of 1:1.

The current study is a follow-up study aiming to explore the effect of the intervention 2.5 years after post-intervention.

The main research questions for the current follow-up study are:

1. Do children participating in the VIA Family intervention experience a greater decrease in symptoms of mental illness from baseline (timepoint 0) to long-term follow-up (timepoint 2) compared with children allocated to TAU?
2. Do parents participating in the VIA Family intervention experience a greater decrease in perceived parental stress from baseline (timepoint 0) to long-term follow-up (timepoint 2) compared with parents allocated to TAU?


Eligibility Criteria:
Inclusion Criteria:

* Child must have address registered in the municipality of Frederiksberg or Copenhagen.
* At least one of the biological parents must have a diagnosis of schizophrenia spectrum disorder, bipolar affective disorder or recurrent major depression.
* The parent with a diagnosis must have had at least one in- or outpatient contact with the mental health system within the lifetime of the child.

Exclusion Criteria:

* Parents who do not speak and understand enough Danish to be able to give informed consent for their own and for the child's participation.
* If all family members are currently engaged in an intensive family intervention program addressing parental functioning and child development, they are excluded from the study.
Using Video Images to Improve Advance Care Planning in Patients With Cancer

The purpose of this study is to study whether preferences for the goals of care for 80 subjects with end-stage cancer are altered after viewing a video outlining the goals of care compared to their initial preferences after hearing a verbal description of the goals of care alone.

The purpose of this study is to study whether preferences for the goals of care for 80 subjects with end-stage cancer are altered after viewing a video outlining the goals of care compared to their initial preferences after hearing a verbal description of the goals of care alone. Subjects will choose among three goals of care, life prolonging care, basic medical care, and comfort care.

Eligibility Criteria:
Inclusion Criteria:

1. Terminal, progressive cancer with poor prognosis whose treatment intent is palliative, based on the following definition:

   * All patients with brain cancer, liver cancer, inoperable non-small cell lung carcinoma, pancreatic cancer, or gallbladder cancer; OR
   * Patients with the following cancers: metastatic colon cancer or stage III or IV non-small cell lung cancer; OR
   * Patients with the following cancers, if first-line therapy has failed and limited response is expected to second-line therapy: breast cancer, colorectal cancer, head and neck cancer, stomach cancer, esophageal cancer, melanoma, leukemia, ovarian cancer, prostate cancer, renal cancer, sarcoma, lung cancer, myeloma, or lymphoma.
   * The terms terminal, progressive, poor prognosis, palliative intent and limited response will be judged by the patient's oncologist (and not by the RSA or consenting professional).
2. Return patient visit (defined as a patient known to the oncologist from previous assessments and treatments, where the working and personal relationship has been established and not a new patient to the clinic).
3. English speaking. Only English-speaking patients will be included in our present study since English is the validated language of our study tools.
4. Given the sensitive nature of the study, clinicians will decide whether the patient is a potentially appropriate subject based on their knowledge of the patient.
5. Able to provide informed consent.
6. Age greater than or equal to 21.

Exclusion Criteria:

1. MMSE \< 25.
2. Psychological state not appropriate for end-of-life discussion as determined by the treating clinician.
Creatine in Treating Patients With Cancer-Associated Weight Loss

RATIONALE: It is not yet known whether the supplement creatine is effective in increasing weight and improving appetite and quality of life in patients who have cancer.

PURPOSE: This randomized phase III trial is studying how well creatine works in increasing weight and improving appetite and quality of life in patients with weight loss caused by cancer.

OBJECTIVES:

* Compare weight-gain effects of creatine vs placebo in patients with cancer-associated weight loss and/or anorexia.
* Determine the effect of these regimens on quality of life in these patients.
* Compare the toxic effects of these regimens in these patients.
* Compare survival rates of patients treated with these regimens.

OUTLINE: This is a randomized, double-blind, placebo-controlled study. Patients are stratified according to primary cancer type (lung vs gastrointestinal vs other), weight loss severity (\< 10 lbs vs ≥10 lbs), age (\< 50 years vs ≥ 50 years), planned concurrent chemotherapy (yes vs no), gender, and prognosis. Patients are randomized to 1 of 2 treatment arms.

* Arm I: Patients receive oral creatine daily.
* Arm II: Patients receive oral placebo daily. In both arms, treatment continues in the absence of unacceptable toxicity as long as treatment is considered beneficial.

Patients are followed every 6 months for up to 5 years.

PROJECTED ACCRUAL: A total of 300 patients will be accrued for this study.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Histologically or cytologically confirmed cancer other than primary brain cancer

  * Considered incurable with available therapies
* History of weight loss ≥ 5 lbs in 2 months or fewer AND/OR estimated intake of \< 20 cal/kg daily
* Determination by attending physician that weight gain would benefit patient
* Perception by patient that weight loss is a problem
* No symptomatic or untreated brain metastases
* No clinical evidence of ascites

PATIENT CHARACTERISTICS:

Age

* 18 and over

Performance status

* ECOG 0-2

Life expectancy

* At least 3 months

Renal

* Creatinine normal

Cardiovascular

* No poorly controlled congestive heart failure
* No poorly controlled hypertension

Other

* Able to reliably receive oral medication
* Must be alert and mentally competent
* No known obstruction of the alimentary tract, malabsorption, or intractable vomiting
* No diabetes that is controlled by insulin
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Chemotherapy

* Concurrent chemotherapy allowed

Endocrine therapy

* No other concurrent adrenal corticosteroids, androgens, or progestational agents within 30 days after study entry
* Concurrent short-term dexamethasone for chemotherapy-associated emesis is allowed
* Concurrent inhalant, topical, or optical steroids allowed

Radiotherapy

* No concurrent radiotherapy to the bowel or stomach
* Other concurrent radiotherapy allowed

Other

* No prior creatine use
* No concurrent tube feedings or parenteral nutrition
Sleep, Circadian Rhythm & Skin Health

The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.


Eligibility Criteria:
Inclusion Criteria:

* Males or females ages 18 years and above
* Capable of giving informed consent
* Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses
* Fitzpatrick Skin Type I-VI
* In good general health
* Willing to cooperate with study instructions

Exclusion Criteria:

* Volunteers 18 years or younger
* Any serious medical or physical condition that would cause the subject significant discomfort with study procedures
* Women who are pregnant, nursing, or who may become pregnant in the next 3 months
California Joint Replacement Registry

The California Joint Replacement Registry (CJRR) was created to meet the need for comprehensive, scientific assessment of devices, treatment protocols, surgical approaches, and patient factors influencing the results of hip and knee replacement surgeries. Importantly, it is a Level 3 registry, meaning it collects and incorporates clinical information and direct feedback from patients about the outcomes of hip and knee replacement surgeries. It is one of only a small number of registries in the United States to do so.

The CJRR's goals are to:

* Collect and report scientifically valid data on the results of hip and knee replacements performed in California, including device safety and effectiveness, post-operative complication and revision rates, and patient-reported outcomes; and
* Promote the use of performance information regarding hip and knee replacements to guide physician and patient decisions and to support programs for provider recognition and reward.

Specifically the CJRR is designed to:

* Minimize burden on participants by using electronic data sources, rather than manual data entry or chart review.
* Compile reports assessing the outcomes associated with different devices and surgical techniques.
* Create benchmarking reports for physicians and hospitals that detail performance data and compare it to statewide averages.
* Transmit safety alerts on devices with short-term results that provoke concern.
* Shape a measurement and reporting system for total hip and total knee replacement surgeries.

The CJRR was developed by the California HealthCare Foundation (CHCF), the Pacific Business Group on Health (PBGH), and the California Orthopaedic Association (COA). PBGH manages the day-to-day operations of the CJRR.

CJRR's data elements are aligned with other major orthopedic registries. The CJRR is a member of the International Consortium of Orthopedic Registries (ICOR) and the International Society of Arthroscopic Registries (ISAR).


Eligibility Criteria:
Inclusion Criteria:

* Receiving hip or knee replacement surgery in California.

Exclusion Criteria:

-
Treatment of Type II Odontoid Fractures Among the Elderly

The purpose of this study is to compare the safety and effectiveness of surgical versus conservative management of type II odontoid fractures among patients \> 64 years of age. Of secondary interest is to determine if there are differences in outcomes between anterior screw fixation and posterior fusion of these fractures.

Hypotheses are as follows:

* Patients receiving surgical management will exhibit better disease specific health and general health related quality of life measures compared to those managed conservatively.
* The rate of radiographic bony fusion will be greater among elderly patients receiving surgical fixation compared to patients receiving conservative management.
* The rate of non union will be greater in the conservative group compared to the surgical group.
* The complication rate will be higher in the surgical group due to the nature of the intervention though the rate of severe and serious complications will be low.

Eligibility Criteria:
Inclusion Criteria:

* All new type II odontoid fractures including those in which the fracture line crosses into the body of C2
* Age \> 64
* Stable and unstable fractures
* \< 3 months post-injury
* No previous treatment for an odontoid fracture

Exclusion Criteria:

* Pathological fractures unrelated to osteoporosis
* Severe dementia or severe mental health problems
* Participation in other trials or unlikely to attend follow-ups
Increasing Physical Activity with a Social Robot-assisted Exercise Intervention in Older Adults with Hearing Loss: a Feasibility and Pilot Randomized Controlled Trial

Objectives To assess the feasibility and acceptability of using a home-based, social robot-assisted intervention (SRAI) for older adults with hearing loss (HL), and to examine the preliminary effects of SRAI on improving physical activity, loneliness, communication, and health-related quality of life in this population.

Hypothesis to be tested SRAI is feasible for implementation at home and acceptable to participants. Upon completing the 10-week intervention and the 1-month follow-up, the intervention group (IG) will report significantly greater improvements in measured outcomes. These findings will support subsequent investigations in a larger-scale randomized controlled trial (RCT).

Design and subjects A two-arm, single-blinded, pilot RCT with individual semi-structured interviews. Chinese adults aged 65 years or older, with mild-to-moderate HL with a pure-tone average of 20-50 dB across octave frequencies 0.5 to 4kHz in both ears.

Study instruments This study will feature a 2 kg, 30 cm tall and 20 cm wide, Cantonese-speaking humanoid social robot named KaKa.

Interventions Each IG participant will receive SRAI at home for 10 weeks. This will include auditory rehabilitation and 60 min/day, 3 days/week of varied multicomponent physical activity following the World Health Organization's evidence-based recommendations. The control group will engage in physical activity at the same intensity level and frequency as the IG without a robot.

Main outcome measures Physical activity levels.

Data analysis Descriptive statistics, an independent sample t-test or chi square test, generalized estimating equation and thematic analysis will be used.

Expected results Participants could benefit from incorporating tailored intervention for physical activity with auditory rehabilitation.


Eligibility Criteria:
Inclusion Criteria:

1. ethnic Chinese aged ≥65 years old living at home;
2. with mild to moderate HL with a pure-tone average of 20 to 50 dB across octave frequencies 0.5 to 4kHz in both ears;
3. no cognitive impairment \[score of ≦2 on the 5-item Abbreviated Memory Inventory for the Chinese (AMIC)\]; and
4. informed consent to participate in this study. Loneliness is not a pre-requisite for taking part in the research. Nevertheless, previous findings from a longitudinal cohort study indicate that approximately 46.6% of older adults with hearing loss reported feeling lonely.

Exclusion Criteria:

1. those with a diagnosis of a major neurocognitive disorder;
2. a history of symptomatic stroke or other disease of the central nervous system;
3. a serious medical or psychiatric illness (e.g., severe depression, schizophrenia, bi-polar disorder) or a visual impairment that would interfere with using a robot or using hearing aids and hearing assistive technologies;
4. have limited access to electricity at home.
Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients

Nutrition is an important part of the recovery process after having a head injury so that subjects can gain strength and fight off infection. Liquid nutrition formulas are often given to patients through a tube that has been placed into the intestines for feeding when they are unable to eat on their own. Some reports suggest that nutrition with extra amounts of the amino acid called glutamine may decrease infections and hospital stay in severely injured patients. The purpose of this study is to evaluate if giving extra amounts of an amino acid called glutamine with liquid nutrition formulas will decrease the risk of infection and length of stay in the intensive care unit after having a head injury.


Eligibility Criteria:
Inclusion Criteria:

* Males
* Nonpregnant females
* Receiving chemotherapy for BMT/HSCT

Exclusion Criteria:

* Documented hepatic dysfunction
* History of cirrhosis
* History of acute renal failure (creatinine clearance \< 25 mL/min)
* Gastrointestinal malabsorptive disorder
Sunscreen and After-sun-lotion Protection in Polymorphic Light Eruption

Polymorphic light eruption (PLE) is a common photodermatosis characterized by the appearance of itching, erythema, papules or vesicles on sun-exposed skin. Though etiology is unclear it is hypothesized that it is an abnormal immune response to autologous antigens generated by ultraviolet radiation (UVR). This randomized, double blinded left-right body side experimental comparison study was designed to assess the preventive effect of a sunscreen and topical DNA repair enzyme-containing after-sun lotion in PLE.

A SPF 30 sunscreen (containing chemical and physical UV filters), an after-sun lotion containing liposomal encapsulated micrococcus luteus lysate with endonuclease activity and photolyase (active AS), and an after-sun placebo formulation (containing no DNA repair enzymes) (placebo AS) has been used in this study. Fourteen PLE patients were enrolled. On day 1, the individual minimal erythema dose (MED) was assessed on patients' buttock skin by exposure to a test ladder of solar-simulated UVR (xenon arc source, Oriel Corp. Darmstadt, Germany). From day 2 to 5, 0.75 individual MED exposures (increased by 0 to 25% per exposure, depending on the erythema response to a preceding dose) were given to a total of four 5-by-5 cm skin test fields on symmetrically located, individual PLE predilection sites on the trunk or extremities. The test fields were treated in randomized and double-blinded fashion either with SPF30 sunscreen 20 min before UVR exposure, active AS or placebo AS (all creams at a concentration of 2mg/cm2) immediately after UVR exposure, or left untreated. Sixty minutes after UVR exposure all test areas were treated with visible light (400 to 450nm, 5J/cm2) to activate the light dependent photolyase DNA repair mechanism. The photo test procedure led to the appearance of PLE symptoms in unprotected test fields of 12/14 (86%) patients, active AS-treated test fields of 6/14 (43%) patients (p\<0.05), placebo AS-treated test fields of 10/14 (71%) patients (p, ns), and no (0%) sunscreen-protected test fields of any patient (p\<0.0001 vs. unprotected test fields, Fisher exact test). These results provide evidence that i) DNA damage is a trigger of PLE, ii) increasing DNA repair can prevent induction of PLE symptoms, and iii) the use of sun care preparations containing DNA repair enzymes may be clinically useful for PLE patients.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of PLE either by typical history and/or typical histology of lesions and/or positive phototesting results

Exclusion Criteria:

* Presence of or history of malignant skin tumors
* Dysplastic melanocytic nevus syndrome
* Photosensitive diseases such as porphyria, chronic actinic dermatitis, Xeroderma pigmentosum, basal cell nevus syndrome, and others
* Autoimmune disorders such as Lupus erythematosus or Dermatomyositis
* Psychiatric disorders
* Systemic treatment with steroids and/or other immunosuppressive drugs
* Pregnancy or lactation
* Antinuclear antibodies
* UV exposure in test fields within 8 weeks before study start
* General poor health status
Structured Training on Oncology Nurses' Performance Related Port A Cath Device

evaluate the effect of structured simulation-based training on oncology nurses' performance regarding port A cath device.

All oncology nurses who are expected to deal with port a-cath device will be recruited in the study pre test will introduced first, then simulated based training will be placed related to port a-cath device care after that , post test will be done immediately and 3 months later to measure nurses knowledge and practice level

Eligibility Criteria:
Inclusion Criteria:

* Oncology nurses who are providing direct care for patients with port a-cath device

Exclusion Criteria:

* Participants who will not be able to complete the questionnaire