cyrilzakka/clinical-trials huggingface dataset:
Osteosclerotic Changes on CT Predict Survival in Prostate Cancer

The study specifically investigated PC patients with bone metastasis and conducted a comprehensive analysis of the correlation between OCs and patient survival outcomes.


Eligibility Criteria:
Inclusion Criteria:

* 1）Histopathological confirmation of prostate adenocarcinoma
* 2）Radiologically verified bone metastasis, assessed through bone scintigraphy and CT imaging from the initiation of systemic therapy until disease progression.

Exclusion Criteria:

* 1）Lacking of complete clinical profiles.
TENS Used for Pain Management During Office Cystoscopy Botox Injections

The purpose of this study is to determine how Transcutaneous Electric Nerve Stimulation (TENS) units affects pain management during office cystoscopic Botox injections and patient satisfaction with the procedure .

Overactive bladder (OAB) is a symptom complex pronounced by urinary urgency, affecting up to 12% of the adult population, with a significant negative impact quality on the life. Cystoscopic intra-detrusor onabotulinumtoxin A is used for the treatment of OAB in participants who do not tolerate or adequately respond to oral anticholinergic medications. The response to the onabotulinumtoxin A injection is transient and requires repeat injections roughly every 6-7 months. Adequate pain control during this procedure is essential for success in the office setting.

Options for adequate pain control during office-based cystoscopy procedures are limited. Currently, varying pain control strategies are being used including local anesthesia (intra-urethral lidocaine, intra-vesicular lidocaine solution), distraction techniques (conversation/music/'squeeze balls'), aromatherapy, intramuscular analgesia, sedation and a combination of these techniques. Despite this, participants often experience pain during the procedure. Trans-cutaneous Electrical Nerve Stimulation (TENS) is a non-pharmacologic, non-invasive and safe method of pain control that involves delivery of electrical impulses to the skin, resulting in a reduction in perceived pain. TENS units have been successfully used for procedural pain management during office hysteroscopy and office colonoscopy. TENS may also help reduce pain during office cystoscopy.

The study is a two arm phase III double-blind, randomized, placebo-controlled trial looking at the effect of TENS unit on pain in participants receiving office based cystoscopic onabotulinum toxin A injection for overactive bladder at the Mayo Clinic in Rochester, Minnesota.

Eligibility Criteria:
Inclusion Criteria:

* Females age 18 years or older
* Scheduled to receive intra-detrusor Onabotulinumtoxin-A injection for Overactive Bladder in the outpatient clinic
* Reads, speaks, and understands the English language
* Able to understand the requirements of the study, including randomization
* Willing and able to provide written informed consent

Exclusion Criteria:

* Previous use of TENS therapy within one year prior to study enrollment
* Has a spouse or first degree relative who has previously used TENS therapy within one year prior to study enrollment
* Currently has an implanted pacemaker or automatic cardiac defibrillator
* History of epilepsy
* Currently pregnant or within 12 weeks postpartum
* Unwilling to be randomized
Effects of Mobile Application Dexteria Fine Motor Skills on Hand Dexterity and Grip Strength in Chronic Stroke Patients

To determine the effects of mobile application dexteria fine motor skills on hand dexterity and grip strength in chronic stroke patients

This study will be conducted to investigate the effects of mobile applications of dexterity fine motor skills on hand dexterity and grip strength in chronic stroke patients. Data will be collected from Jinnah hospital Lahore and Riphah Rehabilitation center Lahore. All 22 patients will be taken using random sampling. Both study groups will be given common treatment of conventional hand function. The subjects will randomly assign to the experiment group with mobile apps training and the control group without mobile app training. Mobile applications like Dexteria, ScribbleKid, PegLight and Bowling game will be used for the purpose of training and success rate will be considered as outcome measure. Test and tools include the Nine Hole Peg Test (NHPT), the Fugl-Meyer Motor assessment (FMA), The Box \&amp; Block Test (BBT), and Grip strength will be assessed using a hand dynamometer. SPSS 25 version will be used for data entry and analysis.

Eligibility Criteria:
Inclusion Criteria:

* Six months to 2 years post stroke
* Participants must be able to open and close their fingers (even only 2 cm of movement)
* Before stroke there must be fully functional hand
* Normal or intact vision

Exclusion Criteria:

* Neurological disorders other than stroke for example multiple sclerosis or Parkinson disease.
* Upper extremities acute orthopaedic conditions.
* Any cardiopulmonary complications
* Medically unstable patients.
Stepped Care for Aphasia

This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. Participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. Check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. Compensation will be provided to participants with aphasia.


Eligibility Criteria:
Inclusion Criteria:

* 18-81 years old
* Native English speaker (English fluency by age 7)
* Aphasia as a result of a left-hemisphere ischemic or hemorrhagic stroke (WAB-R Aphasia Quotient \< 93.8)
* At least 1-month post-stroke
* Confirmation of left hemisphere stroke per medical records
* Discharged from hospital
* Participant is willing and able to consent for themselves.

Exclusion Criteria:

* Uncorrected hearing or visual impairment that prevents completion of experimental activities as determined by self-report
* History of other neurological disorder or disease beside stroke (e.g., dementia, traumatic brain injury) as determined by self-report and/or medical records
* Self-reported history of premorbid learning disability
* Severe auditory comprehension deficits (as indicated by a score of more than two standard deviations below norms on the Auditory Verbal section of WAB-R)
A Multinomial Process Model of Moral Judgment

The main goal of this project to investigate the psychological processes underlying moral judgments in social dilemmas. We will examine neuroendocrine determinants of moral judgment by investigating the effects of exogenous testosterone

* Medical Screening Interview: Participants will be asked to answer several questions to identify potential medical and non-medical conditions that would preclude the self-administration of testosterone.
* First Saliva Sample: Participants will be asked provide a saliva sample after they completed the medical screening interview.
* Testosterone Self-Administration: Immediately following the first saliva collection, participants will self-administer spray puffs of either testosterone or placebo.
* Relaxation: Participants will be given the opportunity to relax for 30 minutes.
* Moral Dilemmas Judgments: Participants will be asked to read a set of 24 moral dilemmas that describe situations in which an actor has to make a decision on whether or not to engage in a particular action (e.g., sacrifice the well-being of one person to protect the well-being of several others). Participants will be asked to indicate whether they consider the described action acceptable or unacceptable.
* Demographics: Participants will be asked to indicate their gender, age, and ethnicity.
* Ear Temperature, heart rate, and blood pressure will be measured before drug administration, and again 20 minutes after drug administration. If temperature changes more than 2 degrees, heart rate changes more than 20bmp, or if blood pressure changes more than 20%, the experiment will be terminated and subjects will be escorted across the street to the University Emergency Room.

Eligibility Criteria:
Inclusion Criteria:

* must be currently enrolled at The University of Texas at Austin

Exclusion Criteria:

* not comfortable with the self-administration of testosterone for the purpose of our study less than 18 years old BMI less than 18 or above 27 suffer from any of the physical health conditions listed on the pre-screen questionnaire (I will not ask about mental health because our study is not about mental health) take any of the medications listed on the pre-screen questionnaire currently pregnant (females) irregular cycle in the past 6 months (females) smoke more than 5 cigarettes/day use cocaine more than once/month (\*\*or should I exclude all those who use any drugs recreationally more than once/month?\*\*) drink more than 10 alcoholic beverages/week
Gene Expression Profiles in Multiple Sclerosis (MS)

The purpose of this study is to test differences in RNA levels between Multiple Sclerosis (MS) patients and normal subjects. RNA provides a "message" from genes altered in diseases. We will also test DNA to determine if there are any small mutations called SNPs in any of the genes. The last tests are two separate tests for markers of inflammation called cytokines and eicosanoids. This research may lead to the discovery of biological markers for MS that are useful for diagnosis and treatment.

This is an investigator-initiated, pilot study of gene expression (RNA) in the blood of patients with multiple sclerosis (MS). The study will enroll patients from the UC Davis Multiple Sclerosis clinic. At a single study visit, we will confirm eligibility, obtain clinical information, and collect blood samples. We will then process these samples to obtain RNA for subsequent microarray analysis. DNA will also be used to examine single nucleotide polymorphisms (SNPs) on chips that allow us to examine 1 million of these SNPs. The SNPs may allow us to diagnose a disease like multiple sclerosis or to predict a treatment or cause. In addition, the DNA may be used to determine if there are any small mutations in any of the genes in the individuals who donate their blood. Additional studies will be done on blood plasma, testing for inflammatory molecules called eicosanoids and cytokines. The data from these tests will be superimposed on the microarray data to determine a molecular profile for each patient. We will then compare the data obtained between patient groups to determine gene alterations specific for each condition.

Eligibility Criteria:
Inclusion Criteria:

* males and females
* any race
* Between the ages of 18 and 70 years
* Diagnosed with a clinically isolated syndrome or the diagnosis of multiple sclerosis using the widely established Macdonald criteria. A 'clinically isolated syndrome' refers to an isolated attack of optic neuritis, transverse myelitis, or brain demyelination. Relapsing-remitting MS is characterized by acute relapses that are followed by some degree of recovery without worsening of disability between relapses. Chronic progressive MS is defined as sustained progression of physical disability, occurring separately from relapses, in patients with MS.
* Control subjects will be male or female, between the ages 18 to 70 years, of any race, with no symptoms of MS.

Exclusion Criteria:

* Children are excluded from the study because MS is generally a disease of young adult onset and is rare in children.
* Evidence of infection or communicable disease, cancer or other known systemic disease, anti-coagulation, known bleeding disorder, illicit drug abuse, or change in medications in the last 30 days (including treatment with steroids).
* Patients receiving any other immune modulating medications (steroids, cyclophosphamide, mitoxantrone, methotrexate, mycophenolate mofetil, azathioprine, IVIG or rituximab) in the prior thirty days will be excluded from the study
Effects of Intramural Fibroids on IVF Outcome

A cohort study involving 200 women candidate for IVF / ICSI cycles . The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts.

On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH),

, estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.

A cohort study involving 200 women candidate for IVF / ICSI cycles . The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts.

On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH),

, estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.

Eligibility Criteria:
Inclusion Criteria:

* age younger than 40 years
* FSH) less than 10 IU/L
* serum prolactin level normal
* uterine cavity abnormality was excluded by hysteroscopy or hysterosalpingography.

Exclusion Criteria:

* abnormal endocrine function (e.g. abnormal thyroid or adrenal function)
* ovarian cysts,
* hydrosalpinx
* endometrial polyps
* male partner with azoospermia
* ICSI performed for preimplantation genetic diagnosis.
Acceptability of Human Papillomavirus (HPV) Self-sampling Tools for Cervical Cancer Prevention

The proposed study aims to increase HPV screening behaviors in Jamaican women by examining the acceptability of HPV Deoxyribonucleic Acid (DNA) self-sampling tools, and to determine the most culturally appropriate and effective message design for promoting such a tool in this context.


Eligibility Criteria:
Inclusion Criteria:

* Jamaican women, aged 30 to 65.

Exclusion Criteria:

* Women who report having had a hysterectomy,
* have had a history of cervical cancer,
* Women who are currently up-to-date on cervical cancer screening (have had a Pap in the last 3 years or have had a Pap smear/HPV co-test within the past 5 years),
* Adults unable to consent, children, pregnant women and prisoners.
Low Level Laser Therapy and Interferential Current in Osteoarthritis

This study aims to evaluate the effectiveness of the low level laser therapy and interferential current in 168 patients with knee osteoarthritis

Interventional

Eligibility Criteria:
Inclusion Criteria:

* History of osteoarthritis of the knee characterized by pain of mild or moderate intensity
* Radiographic evidence of grade 2 or 3 osteoarthritis based on the Kellgren and Lawrence radiographic entry criteria
* Patients with knee osteoarthritis (s) according to the ACR criteria
* VAS 3 to 8
* 5 to 12 Lequesne
* No complaint of pain in other joints of the lower limbs
* Without neurological and cognitive disorders
* No loss of sensation in the lower limbs
* No surgery on the knee (s) in the last 6 months
* Pain symptoms for at least 6 months
* No infiltrations (s) knee (s) in the last 4 weeks
* No use of analgesics 4 hours before treatment

Exclusion Criteria:

* Individuals younger than 18 and older than 80 years
* Complaints from other diseases of the lower limbs, knee prosthesis and / or hip joint instabilities and / or surgery in lower limbs, heart disease, uncontrolled hypertension and diabetes, coagulation disorders in anticoagulant therapy, pregnant women, fibromyalgia and individuals who can not perform isokinetic test who have difficulty performing the TUG, and those that are experiencing abnormal sensitivity to algometry
Lifestyle Intervention for Women With Recent Pre-eclampsia or Gestational Diabetes Mellitus ('Mom's Healthy Heart')

The aim of this pilot intervention study is to develop and test a tailored web-based lifestyle modification program for women with recent preeclampsia or gestational diabetes. Women will start the study 3-15 months postpartum. After obtaining written informed consent and confirmation of eligibility criteria, eligible women will be included in the pilot study using a single arm study design (all women will be assigned to the lifestyle intervention program). Participants will be provided access to a web-based lifestyle intervention program with personalized coaching from a registered dietician.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of preeclampsia or gestational diabetes in recent pregnancy, confirmed by medical record review
* capable to speak and read Norwegian
* access to internet enabled mobile devices that use either iOS or Android operating systems

Exclusion Criteria:

* Diagnosis of chronic hypertension or diabetes mellitus
* current use of blood pressure lowering medication
* medication known to affect glucose tolerance
* active self-reported eating disorder
* history of heart disease, stroke or kidney disease
* history of gastric bypass or bowel surgery resulting in malabsorption
* active medical problems that would interfere with following the diet, or with changes in blood pressure and/or weight
Nerve Sparing Radical Hysterectomy VS Radical Hysterectomy: Safety and Clinical Efficacy

Cervical cancer in young patients increased significantly in recent years, and early surgical treatment for patients with 5 years of survival rate is as high as 90%, But the traditional extensive hysterectomy (RH) caused by intraoperative pelvic autonomic nerve may damage the bladder and rectum and the incidence of complications such as sexual dysfunction is nearly 25% to 80%, thus seriously affect the patient's quality of life.Pelvic autonomic nerve preservation system of extensive hysterectomy (NSRH) can decrease the complications of above, but at home and abroad mainly adopts pulling the urine tube time, determination methods of residual urine volume, bladder function are studied in only a few scholars urine flow mechanics method is applied to carry on objective appraisal limited cases of postoperative bladder function, and the anorectal function damage ，we can use the anorectal dynamics to get objective index of anorectal function .overall research lack of large sample research of dynamic system. No objective index to evaluate the anorectal function In the early stage of the study, we have conducted about uterine ligament, sacral ligaments and nerve distribution of the bladder cervix vaginal ligament of experimental research, provide the neural anatomy basis for NSRH operation, and based on research for innovative operation scheme is put forward.Proposed on the basis of the above research, this study adopt the internationally used - urine flow mechanics, the method for evaluating the bladder function of NSRH, RH, two kinds of the injured function of bladder surgery patients before and after operation of comparative study, the change of dynamic assessment before and after surgery in patients with bladder function,and the anorectal function dameage and than provide the basis for further treatment.


Eligibility Criteria:
Inclusion Criteria:

* Cervical Cancer FIGO(2009) IA2,IB1,IB2,IIA1,IIA2

Exclusion Criteria:

* Cervical Cancer FIGO(2009) \> IIb
* Patients received radiotherapy before opration
* The patient refused to sign a consent form.
The Therapeutic Effect of Immunotherapy in Patients With Advanced Lung Squamous Carcinoma

The aim of this observational study is to investigate the treatment trajectory of immunotherapy in patients with squamous non-small cell lung cancer (sq-NSCLC). The primary objective is to identify potential indicators that can predict the efficacy of immunotherapy and explore strategies to prolong its effectiveness in sq-NSCLC patients. Biological specimens and medical imaging data will be collected from patients already receiving immunotherapy as a first-line treatment, and follow-up will be conducted to analyze prognosis based on different patterns.

The medical imaging data will be collected retrospectively and prospectively and the blood samples and tumor tissues will be collected prospectively.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with sq-NSCLC;
* Receiving immunotherapy combined with or without chemotherapy as first-line treatment;
* ≥ 18 years and ≤ 80 years old;
* No previous treatment in the lungs or any other organ.

Exclusion Criteria:

* History of cancer treatment;
* History of other malignant tumors;
* Irregular treatment or poor compliance;
* Incomplete clinical information or lost to follow-up.