cyrilzakka/clinical-trials huggingface dataset:
The Effects of PNF Stretching on Anaerobic Power and Motor Performance in Adolescent Male Volleyball Players

This randomized controlled study aimed to examine the effects of proprioceptive neuromuscular facilitation (PNF) stretching exercises on anaerobic power and motor performance in adolescent male volleyball players. Eighteen participants aged 15 to 17 years were randomly assigned to an experimental group and a control group. The experimental group performed PNF stretching exercises three times per week for six weeks, in addition to their regular volleyball training. The control group continued their standard volleyball training without PNF stretching. Outcome measures included anaerobic power, flexibility, balance, speed, push-up, and crunch tests. The study hypothesizes that PNF stretching will improve motor performance indicators in adolescent athletes.

This clinical trial investigates the effects of a six-week proprioceptive neuromuscular facilitation (PNF) stretching intervention on motor performance in adolescent male volleyball players. A total of 18 participants with at least 6 months of volleyball training experience were randomly divided into two groups: the experimental group (n=9) and the control group (n=9). The experimental group received PNF stretching exercises in addition to their routine training three times per week for six weeks, while the control group continued only with their routine training.

The main outcome measures were anaerobic power (Margaria-Kalamen Test), flexibility (Sit-and-Reach Test), balance (Flamingo Balance Test), speed (20 m sprint), upper body strength (Push-up Test), and core strength (Crunch Test). Pre- and post-test evaluations were conducted. This study contributes to the growing body of literature on flexibility and functional performance development in adolescent athletes and aims to support evidence-based training practices in sports sciences.

Eligibility Criteria:
Inclusion Criteria:

* Male participants
* Aged between 15 and 17 years
* At least 2 years of volleyball training experience
* Voluntarily agreeing to participate in the study
* No recent musculoskeletal injuries (in the last 6 months)

Exclusion Criteria:

* Participants with any diagnosed neurological or cardiovascular disorder
* Current use of performance-enhancing drugs or supplements
* History of lower extremity surgery
* Inability to complete the training or testing sessions
* Failure to provide written informed consent
Vaccine Health Literacy Related Text Message Reminders to Increase Receipt of Second Dose of Influenza Vaccine for Young, Low Income, Urban Children

Influenza remains a potentially significant and largely preventable source of morbidity and mortality, yet vaccine coverage is low. Young children are at particular risk for underimmunization because they may need to receive 2 doses in a current season. Even among those young children that initiate vaccination, only 40% receive the important second dose, yet one dose does not confer adequate protection. Low-income, urban children may be at particular risk of not receiving two doses. While traditional mail and phone immunization reminders notifying families that a vaccine is due have had limited efficacy in low-income, urban populations, we have demonstrated the success of using text messages. Comparing the effectiveness of different forms of reminders on receipt of this critical second dose of influenza vaccine has not been studied. Besides failure to remember to return for subsequent doses, receipt of 2 doses of influenza vaccine in a season can be affected by limited health literacy regarding influenza vaccination, particularly associated with understanding the need for a second dose since not all children require it. Text messaging offers the ability to combine health literacy promoting information and reminders in a scalable, efficient manner for populations at high risk for underimmunization, limited health literacy, and influenza spread. Therefore, the purpose of this study is to determine whether the provision of interactive vaccine health literacy-promoting information in text message vaccine reminders improves receipt and timeliness of the second dose of influenza vaccine within a season for underserved children in need of two doses.


Eligibility Criteria:
Inclusion Criteria:

* Parenting adult of child age 6 months through 8 years
* Child receives care at study site (visit in last 12 mths)
* child received influenza vaccine and needs a second this season
* Parent has cell phone has text message capability
* Parent speak English or Spanish
* Can read text messages

Exclusion Criteria:

* Parent does not speak English or Spanish
* Parent does not have cell phone with text messages
UTI Reference Standard: Delphi Method

This study is set up by an international core group consisting of infectious disease specialists, geriatricians, urologists, microbiologists, emergency physicians and primary care physicians to develop a consensus-based research definition of urinary tract infections. The absence of such a reference standard leads to misclassification bias and heterogeneity between studies making progress in the field of UTI difficult, for example with much needed near patient diagnostic tests.


Eligibility Criteria:
Inclusion criteria:

* Medical specialist working in the following fields: infectious diseases, urology, geriatric medicine, acute/emergency medicine, intensive care medicine, microbiology, and primary care
* Clinical and/or research experience with urinary tract infections

Exclusion criteria:

* Residency not completed yet
* Working in a different field than described above
Chinese Obesity and MEtabolic Surgery Database (COMES Database)

The purpose of the Chinese Obesity and MEtabolic Surgery Database (COMES Database) is to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the Chinese population.

COMES Database is a prospective managed national database to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the Chinese population.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed as obesity undergoing metabolic and bariatric surgery.

Exclusion Criteria:

* Patients treated by non-surgical modalities.
Pulsed RF Neuromodulation and Leukocyte-Rich PRP for Refractory Low Back Pain

This clinical trial aims to check the safety and efficacy profile of pulsed radiofrequency (RF) neuromodulation combined with leukocyte-rich platelet-rich plasma (PRP) injections for the treatment of refractory low back pain due to multifidus dysfunction. The trial will compare two groups: one receiving standard physical therapy and the other receiving pulsed RF neuromodulation and physiotherapy.

Low back pain is a common condition, often associated with multifidus muscle dysfunction, which can result from aging, obesity, or limited movement. This dysfunction is characterized by fatty infiltration and loss of muscle function. Surgical procedures involving posterior or transpedicular screw insertion can exacerbate this issue by damaging the multifidus muscle, leading to persistent pain.

This study will investigate the effects of pulsed RF neuromodulation on the L2 and L3 segments bilaterally, with each side receiving treatment for 6 minutes. In addition, leukocyte-rich PRP will be injected into the multifidus muscle, and patients will undergo a physiotherapy regimen. The primary outcomes will be compared with those of a control group receiving only physical therapy.

Eligibility Criteria:
Inclusion Criteria:

* Refractory low back pain due to multifidus dysfunction.
* Pain persisting for more than 6 months despite conventional treatments.
* Ability to provide informed consent.

Exclusion Criteria:

* Previous spinal surgery within the last year.
* Current use of systemic steroids or immunosuppressive medications.
* Known bleeding disorders or anticoagulant therapy.
* Pregnancy or lactation.
* Severe psychiatric or cognitive disorders.
* Any Congenital or Non-congenital disorders
Ultrasonography Screening for Breast Lesions During Pregnancy and Lactation

All breast disorders found during pregnancy and lactation should be carefully evaluated. Most of them are benign e.g., lactating adenoma, galactocele, fibroadenoma or inflammatory disorders e.g., mastitis, abscess formation, granulomatous mastitis, but it is essential to exclude pregnancy-associated breast cancer (PABC), which is too often diagnosed late Ultrasound is the first line breast imaging technique during pregnancy and lactation as Development of alveoli during pregnancy might not occur symmetrically, and these can be felt as focal nodularities, or even feel similar to masses, any suspicion of a mass should be assessed with US . If US illustrates glandular tissue and this correlates with the examiner presumption, no further work-up needs to be done. However, if presence of a mass is highly assumed, further follow-up by mammography, MRI and biopsy, when necessary, must be performed


Eligibility Criteria:
Inclusion Criteria:

* Pregnant and lactating women with or without complaining of breast pain or breast lump referred from Obstetric and Gynecological outpatient clinic or surgery outpatient clinic

Exclusion Criteria:

* Non pregnant, non-lactating females, females with previous breast surgery or breast mass lesions before pregnancy or lactation.
The Cranial-caudal Mixed Medial Approach for Laparoscopic Right Hemicolectomy

To explore the feasibility and effectiveness of the cranial-caudal mixed medial approach in laparoscopic right hemicolectomy with complete mesocolic excision. Laparoscopic right hemicolectomy using the cranial-caudal mixed medial approach is safe and feasible, can shorten the operation time, reduce the risk of intraoperative bleeding, and has good clinical results.

The data of patients undergoing laparoscopic right hemicolectomy performed in the same surgical group of gastrointestinal surgery at Northern Jiangsu People's Hospital from February 2017 to June 2022 were retrospectively analyzed. According to different surgical approaches, patients were divided into the cranial-caudal mixed medial approach group and the medial approach group.

Intraoperative and postoperative data were collected. Intraoperative data is obtained through surgical records and pathological reports, including total operation time, Laparoscopic procedure time, Intraoperative blood loss, sample length, number of lymph nodes collected, and number of positive lymph nodes. Postoperative data includes exhaust time, liquid intake time, postoperative hospitalization and complications. Among them, complications are short-term postoperative complications (surgical related complications, non-surgical related complications) within the first 30 days after surgery (or throughout the hospitalization period, if more than 30 days, and are classified according to the Clavien-Dindo classification method.

To explore the feasibility and effectiveness of the cranial-caudal mixed medial approach in laparoscopic right hemicolectomy with complete mesocolic excision.

Eligibility Criteria:
Inclusion Criteria:

* Age range: 18-70 years old
* Right colon cancer confirmed by colonoscopy and pathological diagnosis
* Single primary tumor without distal metastasis
* Laparoscopic operation

Exclusion Criteria:

* Age below 18 and above 70 years old
* Patients who need urgent surgery
* Persons with a history of malignant tumors
* Multiple primary tumors or distant metastases
Quality of Life Impact of Nasal Airway Treatment With Aerin Medical Device

Evaluation of long-term (5-year) quality of life after nasal airway obstruction treatment with the Aerin Vivaer Stylus

This is a prospective, non-randomized, multi-center follow-up study to collect long term quality of life (QOL) data on a cohort of patients who participated in the Aerin Medical TP258 study "A Prospective, Multi-Center, Non-Randomized Study to Evaluate Treatment of Nasal Airway Obstruction Using the Aerin Medical Device". The TP258 study followed subjects out to 26 weeks post-procedure. This QOL study will collect data at 12, 18, 24, 36, 48 and 60 months post-procedure.

Eligibility Criteria:
Inclusion Criteria:

* Received nasal obstruction treatment in Aerin Study TP 258

Exclusion Criteria:

* Unwilling to participate in this long-term study
A Modified Tunnel Approach in Treatment of Gingival Recession

Objectives: To clinically evaluate the healing of Miller Class I and II isolated gingival recessions treated with the modified tunnel approach (mTA) versus the conventional tunnel technique (cTT) in conjunction with subepithelial connective tissue graft (SCTG).

Material and Methods: In this split-mouth study, thirty healthy patients exhibiting two isolating anterior Miller Class I and II gingival recessions were treated with mTA + SCTG and cTT + SCTG. Treatment outcomes were assessed at baseline, 3-months and 6-months postoperatively. The primary outcome was root coverage esthetic scores (RES).

Various techniques have been suggested for the treatment of isolated mandibular recessions e.g., envelope, coronally advanced flaps double pedicle flap or tunneling procedures combined with laterally positioned pedicle flaps in conjunction with SCTG. Despite the fact that the mentioned techniques appear to improve root coverage, the success in terms of complete root coverage has high variability and thus it is still unknown which approach may lead to the most predictable outcomes. The limited evidence from the literature points clearly to the clinical importance of developing new concepts for predictable of isolated mandibular recessions.

The MTA is a dual flap approach; that starts with full thickness flap (avoiding papilla incision) till the level of the mucogingival junction. On reaching the level of the vestibular mucosa, a partial thickness flap is applied to undermine the base of the flap. Using this dual approach carries two main advantages: avoidance of severing the gingival blood supply through the full thickness flap, in addition to minimizing the tension on the flap tissue through using the partial thickness flap at the above-mentioned site.

In this trial, the mTA has been proposed for the surgical treatment of isolated mandibular recessions due to the following advantages: 1) it avoids vertical releasing incisions. 2) it doesn't incise the papilla, which may improve the vascularization of the area plus stabilizing the soft tissue flap. 3) it is suitable to patients with thin gingival biotype.

Eligibility Criteria:
Inclusion Criteria:

* except for chronic periodontitis, our patients were systemically free
* Two mandibular Miller Class I or II recession sites
* at least 2 mm attached gingiva.
* at least 3 mm depth of recession.

Exclusion Criteria:

* Systemic diseases.
* Smokers or formal smokers
* Pregnant or lactating females
* History of antibiotic therapy at the last 6 months
* Patients who are not willing to follow the study protocol
Comparison of 3 in Vivo Microscopic Imaging Techniques for the Diagnosis of Pigmented Tumors

Reflectance confocal microscopy (RCM) is the reference in vivo imaging technique for identifying malignant melanocytic tumors prior to surgical excision. However, it is not widely used due to its high cost and highly technical and time-consuming nature.

In addition to Reflectance confocal microscopy (RCM), it currently use 2 less expensive dermatoscopes that also allow in vivo diagnosis: super-high magnification dermoscopy (D400) and Fluorescence-Advanced videodermatoscopy (FAV).

Several studies have demonstrated their interest in the in vivo diagnosis of melanocytic tumors, but without any comparison between these methods.

In our current practice, many patients have benefited from these 3 imaging modalities for benign and malignant lesions.

Therefore, our aim is to analyze these images and compare their performance in the diagnosis of benign and malignant pigmented lesions.

Eligibility Criteria:
Inclusion Criteria:

* Patients with a pigmented skin lesion of more than 3mm diameter which have benefited systematically of all 3 imaging techniques at the same time, followed by either a surgical excision or annual imaging monitoring.

Exclusion Criteria:

* Bad quality images
* Insufficient number of images
* Uncertain diagnosis given by the pathologist
* Refusal
Evaluation of an Herbal Extract on Sleep Parameters

The overall purpose of this interventional study is to investigate how a specific herbal extract influences the quality of sleep in middle-aged women with mild to moderate insomnia. During the study, the participants are asked to take the test drink every night for two weeks. Both objective (Oura ring) and subjective (analog sleep diaries, questionnaires) measures are included to evaluate sleep parameters as well as perceived alertness and impact on daily functions. The primary outcome is sleep onset latency (SOL), which is the time it takes for a person to fall asleep. Secondary outcomes which will be evaluated include time spent in different sleep stages, number of times waking up during the night, and various qualitative ratings of energy levels and mood during the day.

Researchers will compare the group with active product and placebo product to see if the consumption of the herbal extract will lead to improvements in the factors mentioned above.


Eligibility Criteria:
Inclusion Criteria:

* Female
* Age 35-60
* BMI 18-30 kg/m2
* Mild to moderate insomnia according to the ISI (Insomnia Severity Index) questionnaire (ISI-value 10-21)
* Matching results from the Oura ring and sleep diaries during the run-in period

Exclusion Criteria:

* Metabolic disease (diabetes, cardiovascular disorders, hypo- or hyperthyroidism, etc)
* Severe psychiatric disorders
* Pregnancy, breastfeeding
* Restless legs or leg cramps that influence sleep and everyday life
* Conditions that prevent sleep through the symptoms that they produce (pain, nightly coughs, etc)
* Breathing problems (asthma, severe snoring, sleep apnea, etc)
* Medication that can influence sleep and/or wakefulness
* Consumption of herbal sedatives during the last month
* Having someone in the household that needs to be tended to during the night and pose a major risk to disturb the research participant's sleep to a large extent.
* Irregular work hours, including shift work at night
* Regularly sleeping more than 1 night per week away from home
* Tobacco or drug use
* Other factors that are deemed to influence participation negatively
Effect of PRP Joint Cavity Combined with Acupoint Injection on Osteoarthritis of Knee Joint

This study collected general data from 90 patients with KOA in the outpatients and ward of Henan Provincial People's Hospital from January 2023 to December 2023 to compare the long-term effects of intra-articular PRP combined with acupoint PRP, intra-articular PRP, and intra-articular HA on symptoms in patients with mild to moderate osteoarthritis


Eligibility Criteria:
Inclusion Criteria:

1. The expected survival period is more than 3 months;
2. The clinical diagnosis was early knee osteoarthritis;
3. Capable of knee injections;
4. chronic joint pain or swelling (\> 4 months);
5. It meets the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2021 Edition) , and the X-ray evaluation results meet the Kellgren-Lawrence scale (K-L scale) level I to level III.

Exclusion Criteria:

1. age over 80 years old;
2. K-L classification is greater than Ⅲ grade;
3. Combined with rheumatoid arthritis, severe osteoporosis, tumor, gout, obvious joint deformity and other diseases;
4. Poor compliance, not according to the provisions of treatment;
5. Pregnant and lactating women;
6. Patients voluntarily withdrew from the study;
7. Patients were lost to follow-up due to various reasons during follow-up.
Corona-Like Illness: Did we Got it Before WHO Announcement of the Disease?

A pneumonia of unknown cause detected in Wuhan, China was first reported to the WHO Country Office in China on 31 December 2019. The outbreak was declared a Public Health Emergency of International Concern on 30 January 2020. The spread and severity of the disease is variable from one country to another. Our team as well as many reports suggested that in some countries a " Flu like illness but much worse" was described in October, November and early in December before the WHO announcement. Was it COVID-19?


Eligibility Criteria:
Inclusion Criteria:

* All subject except excluded group

Exclusion Criteria:

* subject diagnosed as COVID-19 positive and their contacts
Acupuncture for Shortness of Breath in Cancer Patients

The purpose of this study is to determine whether acupuncture is effective in relieving shortness of breath among breast and lung cancer patients.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of local or metastatic breast or lung cancer
* Shortness of breath with onset after cancer diagnosis
* Life expectancy of at least 4 weeks

Exclusion Criteria:

* Prior acupuncture
* Other conditions suspected of causing shortness of breath, such as congestive heart failure, sarcoid disease, pneumonia, or obesity
* No chest wall deformity
* Neuromuscular disorders
* Pulmonary vascular disease
* Anemia
* Uncontrolled pain or infection
* Heart valve dysfunction
A Multidisciplinary Intervention in Total Knee Arthroplasty

The purpose of this study is to investigate the effectiveness of cognitive behavioral therapy delivered as an e-therapy program, combined with physical exercise delivered by physiotherapists, for patients on waiting list for total knee arthroplasty. The patients will be randomized to either 1) a non-surgical program consisting of web-based cognitive behavioral therapy combined with physiotherapy, 2) total knee arthroplasty (TKA) surgery followed by web-based cognitive behavioral therapy combined with physiotherapy, or 3) a control group who undergo TKA followed by standard physiotherapy.

The study is a multidisciplinary trial testing an intervention delivered by physiotherapists. Up to 20% of total knee arthroplasty (TKA) patients continue to experience moderate/severe pain 12 months after TKA. While physical therapy (PT) and cognitive-behavior therapy (CBT) have shown promise for improving outcomes, they have not been evaluated in combination or in patients at risk for chronic pain after TKA. This trial will evaluate PT+CBT combined, either as a substitute for or as a supplement to TKA for patients at risk for chronic pain after TKA.

Pilot/Feasibility study:

The study will include a feasibility/pilot study with 15 patients to be performed from November 2018. The intervention and study procedures may be modified based on results from the feasibility/pilot study.

Full scale Randomized Controlled Trial (RCT):

The full-scale RCT will include 282 patients scheduled for TKA. Patients will be randomly assigned to one of three groups: 1) non-surgical intervention (i.e., PT+CBT), 2) a combination of TKA with pre- and postoperative PT+CBT, or 3) A control group receiving TKA and usual care follow-up. Primary outcome: The Pain subscale from the KOOS. The intervention has the potential to improve outcomes for patients who currently obtain little benefit from standard TKA.

Cross-sectional observational study: Patients declining to participate in the RCT will be offered the option to participate in a separate cross-sectional study. The inclusion and exclusion criteria will be identical to the RCT. Patients who agree to participate in the cross-sectional study will complete the same baseline questionnaires as in the RCT and are asked about the reasons they did not want to participate in the RCT.

Eligibility Criteria:
Inclusion Criteria:

1. Scheduled for TKA for OA at Lovisenberg, Oslo; Martina Hansen, Bærum, or Coastal Hospital Hagevik, Bergen
2. Age 18 - 79 years
3. ASA grade 1-3
4. KL grade 3 or 4
5. BMI\<40
6. Able to read and write in Norwegian

Exclusion Criteria:

* Diagnosis of dementia or sero-positive rheumatic disease
* Previously undergone uni or patellofemoral prosthesis in the index knee
* Large axis deviation or instability requiring use of hinged implants
* Scheduled for unicompartmental arthroplasty or revision surgery