cyrilzakka/clinical-trials huggingface dataset:
Examining the Relationship Between Burnout and Career Commitment of Occupational Therapists in Skilled Nursing Facilities

A mixed methods cross-sectional survey was created for the proposed research questions. The survey is best for this research as it will indicate if occupational therapy practitioners (OTPs) are burnt out through the Maslach Burnout Inventory - Human Services Survey (MBI-HSS) and will provide information on a direct link to OTPs' intention of leaving or OTPs\&#39; decreased perceived quality of treatment interventions. By having clear evidence of the linkage, qualitative research generates non-numerical data to develop a deeper understanding of why OTPs are leaving the profession. By utilizing online recruitment methods, this will allow OTPs easier access and easier ability to administer. Participants will be recruited utilizing purposeful and snowball sampling techniques. Participants will be recruited from employer emails, social media and alumni pages.

Data will be collected for approximately one month, giving participants time to participate and pass along the survey to other colleagues. The survey will be completed on an anonymous online platform for ease and convenience of participation. The survey is broken into four sections. Before starting the survey, participants had to indicate that they acknowledge and accept the informed consent. If they deny the informed consent, the survey was be submitted without asking questions. Section two contained the demographic data. Section three contained the MBI-HSS. Section four included the non-standardized quantitative and qualitative questions related directly to the intention of leaving the profession and their perceived quality of treatment interventions.

Burnout is a topic that will always be around and talked about. In order to gain a better understanding of the role that burnout plays in the field of occupational therapy and the direct effects if has on therapists and the profession is important. Finding out the effects can help companies and the American Occupational Therapy Association address these issues and adjust to the current needs.


Eligibility Criteria:
Inclusion Criteria:

* Occupational Therapists or Certified Occupational Therapy Assistants Currently working in skilled nursing facilities or have worked in the last 2 years Any age range, any state Must have an active OT or COTA license

Exclusion Criteria:

* OT or COTA in a field other than skilled nursing facilities
Chiropractic Treatment With Counseling Versus Counseling Alone for Promoting Smoking Cessation

Tobacco use is the number one killer of Americans today. Most current smokers have tried and failed to quit at least once. Smokers are addicted to the nicotine in tobacco products, and withdrawal from smoking can lead to physical symptoms such as irritability, anxiety, nervousness, depression and insomnia.

This study will examine the effects of tobacco cessation counseling and chiropractic treatments on smokers who desire to quit.


Eligibility Criteria:
Inclusion Criteria:

* Adults 18 yrs and above
* Smokers with desire to quit smoking

Exclusion Criteria:

* Received chiropractic treatment or other manipulative therapies within the last month
* Have received any therapy for smoking cessation during the last month
* Visceral, systemic or joint inflammatory disease
* A history of low back surgery
* Osteoporosis
* Prolonged systemic corticosteroid medication
* Pregnancy
* Recent spinal fracture
Safety and Efficacy of Levomilnacipran ER (Levomilnacipran SR) in Major Depressive Disorder

The purpose of this study is to evaluate the efficacy, safety, and tolerability of Levomilnacipran ER compared to placebo in patients with Major Depressive Disorder (MDD).


Eligibility Criteria:
Inclusion Criteria:

* Men and women, 18-75 years old
* Currently meet the DSM-IV-TR criteria for Major Depressive Disorder
* The patient's current depressive episode must be at least 6 weeks in duration

Exclusion Criteria:

* Women who are pregnant, women who will be breastfeeding during the study, and women with childbearing potential who are not practicing a reliable method of birth control.
* Patients who are considered a suicide risk
* Patients with a history of meeting DSM-IV-TR criteria for
* a. any manic or hypomanic episode
* b. schizophrenia or any other psychotic disorder
* c. obsessive-compulsive disorder.
Overall Functional Evaluation After Amputation of the Lower Limb; Locomotion, Energy Efficiency and Strategies to Adapt to the Prosthesis

It appears necessary to confront the reality of the contribution of technological progress in the creation of prostheses with the specific features of lower limb amputees. These contributions must be clearly identified in their different functional dimensions. This justifies a quantitative approach to the locomotor abilities of these patients, with regard to bioenergy parameters (consumption of oxygen while walking) and motor biomechanical parameters (quantified analysis of movement), so as to measure the real impact of the proposed prosthesis technology, as a complement to classical qualitative approaches.

In this context, Dijon CHU, thanks to its Technological Investigation Platform (PIT, CIC 1432), and the company PROTEOR established a research partnership aiming to:

* Refine the indications for the prescription of new products, by ensuring that they correspond to the profiles of the patients concerned and their true needs,
* Study the underlying adaptive mechanisms, and establish new recommendations for their use, depending on the profiles of the users,
* And ultimately, better evaluate, in a more rigorous and systematic manner, the prostheses available on the market.

The research protocol presented in this document aims to provide a framework for part of the explorations that will be conducted in the context of this partnership. Lower-limb amputees who will be evaluated in this research will wear these prostheses (foot and/or knee prostheses), which bear the CE logo, and thus present all of the safety and performance conditions required for their use by these patients (prostheses destined for usual prescriptions), the objective of the study was not to evaluate the prostheses as such, but to explore and quantify the impact of these prostheses and their eventual modifications on the locomotor abilities of the patients concerned.

The investigations will be conducted using non-invasive evaluation tools available on the PIT platform, with no modification in the usual management of these voluntary patients.


Eligibility Criteria:
Inclusion Criteria:

* Patients able to understand simple instructions, the fitting instructions and to provide informed consent
* Man or woman aged \> 18 years)
* Lower-limb amputee, transtibial or transfemoral amputation

Exclusion Criteria:

* Adult under guardianship
* Subject without national insurance cover
* Pregnant or breast-feeding women
* Patients with hip desarticulation
* Subjects presenting severe associated diseases affecting gait
Effect of Peripheral Laser Iridotomy Placement on Post-operative Visual Function

To evaluate the influence of superior versus temporal laser peripheral iridotomy location on post-operative visual acuity and contrast sensitivity.


Eligibility Criteria:
Inclusion Criteria:

* Angle-closure glaucoma
* Angle-closure glaucoma suspect

Exclusion Criteria:

* Monocular status
* Previous intraocular surgery
* Visual acuity worse than 20/40
* Prior episode of acute angle-closure glaucoma
* Pregnancy
A Study in Adults With Inflammatory Bowel Disease (IBD) Receiving Vedolizumab in the Patient Support Program (PSP) in Brazil

The primary reason of this study is to observe current and past treatment in adult participants receiving Vedolizumab, intravenous (IV) or subcutaneous (SC), for IBD in Brazil. There is no treatment involved in this study, this is only an observational review of past and ongoing treatment data relating to Vedolizumab treatment for IBD (including Ulcerative Colitis \[UC\] and Crohn's Disease \[CD\]).

This is a non-interventional, observational study in participants with IBD participating in the PSP. This study will enroll approximately 2160 participants. The study is divided into two cohorts according to data collection:

* Retrospective Cohort
* Prospective Cohort

The retrospective cohort is for participants that were included in the PSP prior to study start. This retrospective cohort will have data of participants that are actively participating in the Program and only their retrospective data will be collected. The prospective cohort is for participants that are starting their participation in the PSP using their data from the consent date until the end of the study or until the discontinuation in the PSP or in the study.

Retrospective and prospective cohorts will be collected from the PSP database, which will be the only source of participants for this study.

This single country trial will be conducted in Brazil. The duration of this observational study will be approximately 26 months.

Eligibility Criteria:
Inclusion Criteria:

• Who participated or who will participate in the "Entre Nós" program and participant who consent to participate in the study.

Exclusion Criteria

• No exclusion of participants is expected in the present study and the quality of the data relies in participant reported outcomes for the "Entre Nós" program.
Methylphenidate (Ritalin®) Effect During Exposure to Exercise and Heat Stress in ADD/ADHD Treated Patients

The purpose of this study is to explore the possible effects of MPH use on physiological functions among ADHD\\ADD patients, by performing a set of physical trials to assess aerobic and anaerobic capacity, to characterize the tendency for muscle break down while performing monitored moderate physical effort and to assess the physiological strain while performing moderate exercise in heat load conditions by using the heat tolerance test.

20 male, non-combat soldiers with a pre-existing childhood diagnosis of ADHD\\ADD, who are chronically treated with MPH will participate in the study. If necessary, civilian volunteers with a childhood diagnosis of ADHD\\ADD may also be recruited to complete the study population (up to 50%, i.e. 10 participants).

1. st encounter: the subjects will receive an explanation of the study and sign an informed consent form, complete a medical questionnaire and undergo physical examination by a physician, including ECG.
2. nd-9th encounter: the subjects will be requested to undergo 10 tests on 8 examination days, which will include the: maximal oxygen consumption test, wingate test, heat tolerance test and step test. Each subject will perform each test twice: once while taking MPH and once with placebo.

Eligibility Criteria:
Inclusion Criteria:

* Civilian volunteers aged 18-25 years.
* BMI range of 17-25.
* Diagnosed with attention deficit disorder (ADD or ADHD) since childhood.
* Routine use of Methylphenidate (at least 5 days a week).
* Without known medical illness or medication use.
* Report of performing physical exercise (twice or more a week).
* Without history of heat injury.

Exclusion Criteria:

* The existence or suspicion of existing cardiac or respiratory disease.
* Infectious disease 3 days prior to the experiment.
Autologous Bone Marrow Stem Cells in Pressure Ulcer Treatment

The aim of the study is to determine the safety and feasibility of an autologous mononuclear stem cells infusion in pressure ulcers of paraplegic patients; and moreover, to evaluate the efficacy of the treatment.

Taking into account the encouraging results obtained in the treatment of non-healing chronic wounds using bone marrow cells Given that treatment strategies for pressure ulcers can be both costly and complex, in this study we examine the possibility of improving pressure ulcer healing using stem cell therapy.

Eligibility Criteria:
Inclusion Criteria:

* Type IV ulcer pressures of more than 4 months topical treatment without response
* No option for conventional surgery
* Age range of 18-75 years old

Exclusion Criteria:

* Patients out of inclusion age range
* Patients with evidences of mental illness
* Patients with evidences of previous alcohol or drugs dependencies
* Pregnant women
* Patients with present or previous malignant disease during the last 5 years, except for basal cell carcinoma
Factors Associated With Cognitive Status in the Elderly

The aim of this study was to investigate the factors related to cognitive status in elderly individuals living in the community. A total of 841 elderly (female: 422, male: 419) living in the community were included in this cross-sectional study. The sociodemographic information of the elderly was recorded. In addition, cognitive status, quality of life, depression and musculoskeletal pain were questioned. The classification and regression tree analysis was used to identify factors associated with cognitive status. Age, depression, quality of life, neck pain, and headache were determinative on the cognitive status of the elderly. Knowing the factors related to cognitive status in elderly individuals living in the community is very important in terms of early diagnosis of factors that may affect the quality of life of these individuals.

Aim: The aim of this study was to investigate the factors related to cognitive status in elderly individuals living in the community.

Methods: A total of 841 elderly (female: 422, male: 419) living in the community were included in this cross-sectional study. The sociodemographic information of the elderly was recorded. In addition, cognitive status, quality of life, depression and musculoskeletal pain were questioned. The classification and regression tree analysis was used to identify factors associated with cognitive status.

Eligibility Criteria:
Inclusion Criteria:

* Participants over the age of 65,
* Living at home,
* Not having mental and communication problems that would prevent the evaluations,
* Volunteering to participate in the study.

Exclusion Criteria:

* Central nervous system diseases affecting cognitive functions.
NAD Augmentation in Diabetes Kidney Disease

A phase 2a trial randomized, double-blind, placebo-controlled, parallel group trial to determine whether NMN administration improves DKD, as indicated by a significantly greater reduction in UACR compared with placebo administration. Eligible participants will be randomized to receive either 1000 mg NMN or placebo twice daily.

This will be two centers, randomized, double-blind, placebo-controlled, parallel group trial to determine whether βNMN, after its daily oral administration, is associated with a greater reduction in the UACR compared to placebo.

The trial will enroll community-dwelling older adults, 60 years or older, with type 2 diabetes mellitus (T2DM) and urine albumin to creatinine excretion ratio \> 100 mg/ g creatinine.

Eligibility Criteria:
Inclusion Criteria:

1. Has T2DM, as indicated by any of the following:

   1. Self-report of diabetes plus the use of a prescribed diabetes medication.
   2. ICD-10 code for diabetes plus current use of a diabetes medication in the electronic medical record.
   3. HbA1c \>6.4%; or 2 fasting glucose \> 125 mg/dL
2. Fasting morning UACR between 100 and 2,000 mg/g creatinine on two separate days
3. If UACR is \> 300 mg/g creatinine, must be currently using an ACE inhibitor or an ARB
4. eGFR \> 30 mL/ min / 1.73 m2
5. Hemoglobin A1c \<9%
6. Able to speak English or Spanish
7. Willing and able to provide written informed consent
8. In addition, female participants must Not be pregnant and not planning to become pregnant over the next 6 months

Exclusion Criteria:

1. Fasting morning UACR \> 2,000 mg/ g creatinine
2. Other laboratory abnormalities:

   1. Has AST or ALT \> 3 times the upper limit of normal
   2. creatinine \> 2.5 mg/dL
   3. Hematocrit \< 0.34 or 0.50 L/L
3. A major adverse cardiovascular event in preceding 3 months
4. Participation in an investigational trial to evaluate pharmaceuticals or biologics within the past 3 months or 5 half-lives, whichever is shorter
5. Hypoglycemia unawareness or other medical conditions which could jeopardize participant's safety.
6. History of alcohol or substance use disorder or dependence (DSM 5 criteria) within the last 2 years.
7. Major depressive disorder, bipolar disorder, schizophrenia, or current psychotic symptoms or behavioral problems that could interfere with study procedures.
8. BMI \> 42.5 kg/ m2
Tantrum Tamers 2.0: The Role of Emotion

This study aims to better understand how to best help parents of young children with problem behavior. Problem behaviors vary between and within children, but can include inattention/hyperactivity, tantrums, and/or noncompliance.

If eligible and choose to participate, this study includes:

A baseline assessment which will include asking a series of questions about parent, child and family, as well as parent-child observations.

If eligible for treatment, sessions occur once per week for approximately 8 to 12 weeks. Sessions include new information and lots of practice and discussion about how to make the skills work best for specific families.

After finishing treatment a post-assessment (similar to BL) conducted.

All of the assessments (i.e., video-and audio-recorded), as well as the sessions with a therapist will be recorded (i.e., video recorded).

Eligibility Criteria:
Inclusion Criteria:

* Clinically significant child problem behavior

Exclusion Criteria:

* Current severe symptoms in parent or child that would prohibit participation (e.g., parent current psychotic or substance use disorder)
Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin

The purpose of this study is to understand how an antibiotic, rifampin, may change the blood levels of another antibiotic, daptomycin, in the body. In addition, the effect of polymorphisms in P-glycoprotein (a protein involved in the removal of daptomycin from the body) on the blood levels of daptomycin will be evaluated. The hypotheses are that rifampin will decrease the blood levels of daptomycin and that the effect will be greater for certain P-glycoprotein polymorphisms.

This will be an open-label, sequential pharmacokinetic study in 12 healthy volunteers. After providing informed consent, participants meeting inclusion criteria will be administered daptomycin 6 mg/kg over 2 minutes and blood and urine samples will be collected over a 24 hour period after infusion. Following this, participants will be given a 13 day supply of rifampin 600 mg/day to be taken at home. After completion of the rifampin course, a second pharmacokinetic sampling will be performed (day 15 overall). Participants will be administered a dose of rifampin 600 mg then once again be administered daptomycin 6 mg/kg over 2 minutes and blood and urine samples will be collected over a second 24 hour period. A blood sample will be obtained at the first study visit for determination of each participant's P-glycoprotein genotype.

Eligibility Criteria:
Inclusion Criteria:

* Ability to provide informed consent
* If female of child bearing potential, on reliable method of contraception and negative pregnancy test at enrollment

Exclusion Criteria:

* Obesity (body mass index \> 30)
* Creatinine clearance \< 80 ml/min
* Creatine phosphokinase \> 2 times upper limit of normal at enrollment
* Aspartate aminotransferase, alanine aminotransferase, or alkaline phosphatase \> 3 times upper limit of normal at enrollment
* History of liver disease or cirrhosis
* History of congestive heart failure
* Allergy or intolerance to rifampin or daptomycin
* Need for concomitant non-study medications during the study period
* Inability to abstain from grapefruit juice or herbal supplements (such as St. John's wort) during the study period
* Receipt of study drugs within 30 days prior to enrollment
* Pregnancy or lactation
* Inability to adhere to study procedures
Language Environment in Children With Cochlear Implants

The Language Environment Analysis (LENA) system is a specific tool for the language environment analysis. Children aged from 18 months to 6 years old, with cochlear implants (CIs), wear an electronic device during a day and their language interactions are registered. Then the investigators can analyze with a specific software four different parameters (adult words, conversational turns, child vocalizations and media exposure) and compare them to the language ability of the children assessed by a speech therapist. With the results, the speech therapist can advise the parents how to improve the language environment to help their children with CIs for their language development. Parents are encouraged to follow these advices at home during few months (5 months +/-1 month). Then there is a new registration of the LENA device and another language assessment are performed, to see if there is any improvement. The investigators also measure the family participation.

Hypothesis : There is an influence of the language environment measured by the LENA system on language development in children with cochlear implants.

Over 24 months the investigators will recruit 90 patients with cochlear implants (CIs) in 2 centers.

Each patient will follow during 5 months and will have three or five visits according to the arm.

Eligibility Criteria:
Eligibility Criteria:\*

Inclusion criteria:

* Congenital profound deaf children
* aged from 18 months to 5 years old 11 months
* with a cochlear implant at least since 6 months
* regular following in speech therapy

Exclusion criteria:

* non-francophone parents
* syndrome (like CHARGE syndrome) or aplasia
* partial insertion of the electrode array
* associated troubles (Autism Spectrum Disorders, mental retardation...)
* visual troubles
* irregular use of the cochlear implant (externe part)
* absence of parental consent
TEAS Enhanced Recovery After Laparoscopic Colon Surgery

The purpose of this study is to observe the effects of transcutaneous electrical acupoint stimulation(TEAS) on postoperative recovery after laparoscopic colon surgery.

Patients were randomly assigned to two groups, receiving TEAS andno stimulation respectively. Interventions were given 30min before anesthesia and 1, 2 , 3 day after surgery, lasted 30min each time . The acupoints of TEAS group are bilateral ST36/SP6 combined with PC6/LI4, and the control group only attach electrodes without electric current. The frequency of TEAS is set to 2/10 Hz. After surgery, the time of meeting discharge criteria, first flatus and defecation were recorded. Score of PONV, life quality, sleep quality and VAS of pain were evaluated 24, 48 and 72h after surgery. The postoperative complications, re-exploration, cost of hospitalization and adverse events were also recorded.

Eligibility Criteria:
Inclusion Criteria:

* Age between 18 to 75 years old；
* ASA I-III；
* Scheduled for elective laparoscopic colon surgery under general anesthesia；
* BMI between 18 and 30；
* Informed consented.

Exclusion Criteria:

* Patients with contraindications to the use of electroacupuncture, such as skin damage or infection at the acupoints；
* Patients with difficulty in communication；
* Emergency surgery；
* Patients who are with distant metastasis;
* Patients who are with history of myocardial infarction or cerebral infarction in the past six months；
* Patients who are with long history of taking NSAIDS，hormone or immunosuppressive agents；
* Patients who are recruited in other clinical trials in the last 3 months；
* Other situations researcher think shouldn't be included.