cyrilzakka/clinical-trials huggingface dataset:
AI Driven National Platform for CT cOronary Angiography for clinicaL and industriaL applicatiOns Registry

The overall aim is to build an AI driven national Platform for CT cOronary angiography for clinicaL and industriaL applicatiOns (APOLLO) for automated anonymization, reporting, Agatston scoring and plaque quantification in CAD. It is a "one-stop" platform spanning diagnosis to clinical management and prognosis, and aid in predicting pharmacotherapy response.

Coronary artery disease (CAD), a blockage of the blood vessels, affects 6% of the general population and up to 20% of those over 65 years of age. CAD is a leading cause of cardiac mortality in Singapore and worldwide, with 19% of deaths in Singapore due to CAD (MOH website).

Numbers of CAD cases are increasing due to ageing and the higher prevalence of contributary diseases such as diabetes. Computed Tomography Coronary Angiography (CTCA) is the first-line investigation for CAD as indicated by the National Institute for Clinical Excellence (NICE) guidelines. Recent Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) and Scottish Computed Tomography of the Heart (SCOT-HEART) trials support CTCA as the dominant means for evaluating coronary anatomy and physiology as it increases diagnostic certainty, improves efficiency of triage to invasive catheterization and reduces radiation exposure when compared to functional stress testing.

Currently, CAD report generation requires 3-6 hours of a CT specialist's time to annotate scans, with inter-observer variability of 20%. In addition, there is no effective singular toolkit to analyse Agatston scores (a measure of calcified CAD), severity of stenosis, and plaque characterisation.

These problems have severely constrained the effectiveness of CTCA as a diagnostic and research tool. The investigators plan to build upon Singapore's competitive advantages in artificial intelligence (AI) to provide a solution to these gaps.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥21 years old
2. Signed informed consent
3. Clinically indicated for evaluation by CTCA

Exclusion Criteria:

1. Individuals unable to provide informed consent
2. Known complex congenital heart disease
3. Planned invasive angiography for reasons other than CAD
4. Non-cardiac illness with life expectancy \< 2 years
5. Pregnancy
6. Concomitant participation in another clinical trial in which subject is subject to investigational drug or device
7. Cardiac event and/or coronary revascularization (percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG) and/or valvular repair/replacement prior to CTCA
8. Glomerular Filtration Rate ≤ 30mL/min
9. Known allergy to iodinated contrast agent
10. Contraindications to beta blockers or nitroglycerin or adenosine
Study Human Digital Support Transitional Care

The purpose of the study is to compare the effectiveness of Divomed in organising complex hospital discharges with a conventional organisation. Effectiveness will be assessed by reducing the length of stay of patients in geriatric short-stay care.

This is an interventional, randomised (ratio 1:1), single-centre, open-label study evaluating Divomed, a digital tool combined with human coordination, to speed up the discharge of people aged over 75 from unscheduled short-stay geriatric hospital admissions to their homes.

The study population will be patients aged 75 or over, admitted for short term unscheduled geriatric hospitalisation and eligible for discharge home.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 75 years ;
* Unplanned hospitalisation from emergency, transfers from other inpatient departments or outpatient medicine;
* Patient eligible for short-stay geriatric hospitalisation estimated to last at least 10 days;
* Patient eligible for a return home;
* Patients who have been informed and have signed an informed consent form. If necessary (for cognitive or other reasons), the information must be given to a third party, i.e. the patient's legal representative or trusted person (independent of the investigator and the sponsor), who may be asked to sign or co-sign the informed consent form (depending on the patient's vulnerability).

Exclusion Criteria:

* Patients scheduled for transfusion, iron infusion or colonoscopy;
* Patients in palliative care;
* Geographical area other than department 37;
* Planned discharge from hospital to a residential establishment for dependent elderly people or to follow-up and rehabilitation care or long-term care units;
* Patient or deprived of liberty by judicial or administrative decision ;
* Patient participating in or being excluded from another clinical trial;
* Patients not covered by a social security scheme.
The Effect of Guided Imagery on Bonding and Breastfeeding After Cesarean

The aim of this study is to evaluate the effect of guided imagery after cesarean section on mother-infant bonding and breastfeeding.

The study will be carried out in two different groups. The practice will start with meeting the women 6-10 hours after cesarean section. After the women are evaluated in terms of eligibility criteria for the research, the women who are eligible will be informed about the research and written informed consent will be obtained from the women who accept. The random distribution of women to the study groups will be carried out using the Block Randomization method. The following applications will be made to the groups.

Intervention Group; The individuals in this group will be provided with guided imagery application. Guided imagery will be applied to the participants in the hospital environment 6-10 hours after the cesarean section. Afterwards, guided imagery application will be requested every day for two weeks.

Control Group; The participants in the control group will perform routine care of the clinic.


Eligibility Criteria:
Inclusion Criteria:

* Nullipar
* Single birth
* Baby being with mother
* Gestational age 37-42 weeks
* Birth weight between 2500-4000 g
* APGAR score of 7 or higher in the 1st and 5th minutes
* The mother does not have a health problem that prevents breastfeeding
* Absence of conditions that prevent sucking, such as frenulum or palate problems

Exclusion Criteria:

* Participant's non-compliance with the research plan
* Interruption of breastfeeding for reasons such as health problems of the mother or baby
* Participants receive professional support for breastfeeding during the study process
* Hearing loss and deafness
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity

The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth factor (NGF).

The purpose of this study is to assess changes in sensory-motor cortical excitability during experimental muscle hyperalgesia across several days provoked by injections of nerve growth factor (NGF) into the Extensor Carpi Radialis (ECR) muscle and delayed onset muscle soreness (DOMS) of the ECR muscle.

It was hypothesized that muscle hyperalgesia across several days would result in:

i) Increased sensory cortical excitability, based on somatosensory evoked potentials by means of electrical stimulation of the radial nerve, (increase of central-parietal evoked-potential P45 and decrease of frontal evoked-potential N30); ii) Increased corticomotor excitability of a ECR (increase map volume and number of active sites), assessed as motor evoked potentials induced by transcranial magnetic stimulation in primary motor cortex (M1); iii) Reduction of alpha oscillation based on nociceptive stimulus-evoked suppression of alpha activity in sensory regions (recording electrodes on contra-lateral parietal area);

Eligibility Criteria:
Inclusion Criteria:

* Healthy men and women
* Speak and understand English.

Exclusion Criteria:Pregnancy

* Drug addiction defined as the use of cannabis, opioids or other drugs
* Previous neurologic, musculoskeletal or mental illnesses
* Lack of ability to cooperate
* History of chronic pain or current acute pain
* Previous experience with rTMS
* Contraindications to rTMS application (history of epilepsy, metal in the head or jaw etc.).
* Failure to pass the "TASS questionnaire" (TASS = Transcranial Magnetic Stimulation Adult Safety Screen)
Impact of an Automated Telephone Intervention on Glycosylated Hemoglobin (HbA1c) in Type 2 Diabetes

Aim 1. Determine the impact of a daily, automated telephone intervention on HbA1c levels compared to standard care in older patients with type 2 diabetes.

Aim 2. Determine the impact of the automated telephone intervention compared to standard care on adherence to prescribed SMBG frequency in older patients with type 2 diabetes.

Aim 3. Determine the impact of the automated telephone intervention compared to standard care on self-reported diabetic control problems in older patients with type 2 diabetes.

Aim 4. Determine the impact of the automated telephone intervention compared to standard care on self-reported attitudes and health beliefs concerning diabetes in older patients with type 2 diabetes


Eligibility Criteria:
Inclusion Criteria:

* Age greater or equal to 55
* Type 2 diabetes
* English speaking
* Ability to use glucose meter

Exclusion Criteria:

* Unable to give informed consent
* Unwilling to allow SMBG levels to be shard with primary care physician
The Effect of tDCS Combined With Functional Task Training on Motor Recovery in Stroke Patients

We propose to enhance the effects of brain plasticity using a powerful noninvasive technique for brain modulation consisting of navigated transcranial magnetic stimulation (TMS) priming with transcranial direct current stimulation (tDCS) in combination with motor-training-like constraint-induced movement therapy (CIMT).


Eligibility Criteria:
Inclusion Criteria:

1. age 18-90
2. first-time clinical ischemic or hemorrhagic cerebrovascular accident as noted in the radiological (or physician's) report;
3. the ability to extend =20° at the wrist and 10° at the metacarpophalangeal and interphalangeal joints of all digits;
4. participants must demonstrate adequate balance while wearing the restraint;
5. the ability to stand from a sitting position and the ability to stand for at least 2 minutes with or without upper extremity support;
6. weakness, defined as score of 15-55 (out of 66) on arm motor Fugl-Meyer (FM) scale; and
7. stroke onset more then 6 months prior to study enrollment.

Exclusion Criteria:

1. significant pre-stroke disability;
2. where applicable (a history of depression before the stroke);
3. any substantial decrease in alertness, language reception, or attention that might interfere with understanding the instructions for the motor testing;
4. excessive pain in any joint of the paretic extremity;
5. contraindications to single-pulse TMS (TMS will be used to measure cortical excitability) such as metal head implants;
6. advanced liver, kidney, cardiac, or pulmonary disease;
7. a terminal medical diagnosis consistent with survival 1 year;
8. coexistent major neurological or psychiatric disease (to decrease the number of confounders);
9. a history of significant drug abuse in the prior 6 months;
10. the use of certain neuropsychotropic drugs such as tricyclics, antidepressants, or 51 of 66 carbamazepine;
11. active enrollment in a separate intervention study targeting stroke recovery; (
12. previously applied constraint-induced motor therapy and/or tDCS treatment for stroke; and
13. a history of epilepsy before stroke (or episodes of seizures within the last six months).
C.A.T.C.H.-I.T.Competent Adulthood Transition With Cognitive, Humanistic and Interpersonal Teaching

The purpose of this study is to adapt depression prevention interventions of proven benefit to the primary care setting in a manner that would be acceptable and potentially available to young adults in the community.

Our study goal is to develop a prototype combination primary care-web based depression intervention for young adults ages 18-24years in urban community and university settings. The content development will include: (1) two brief (15 minutes) primary care counseling sessions, (2) one introductory web based module, (3) four web-based cognitive behavior teaching modules, (4) three web-based modules discussing relationship building skills (IPT), and (5) a final web module discussing self-recognition, evidence-based treatment, and stigma. Eight young adult volunteers will evaluate the program in three loops of evaluation and revision in a modified focus group approach. This protocol was approved by the Johns Hopkins Joint Committee on Clinical Investigations.

Primary Outcomes:

The primary outcome variables relate to the functionality and acceptability of the intervention. These variables include readability, ease of understanding, acceptability, and helpfulness of each component of the intervention, and a global rating of each

Secondary Outcomes:

Process measures (time on site, exercise completion), outcomes (mood and intermediate outcomes-social adjustment, dysfunctional thinking), and knowledge and opinions of current treatments for depression. These data will be helpful in planning for a future Focus groups of 5-10 individuals have been used successfully to provide initial product evaluations or to develop general themes in attitude research. Summary statistics will be collected.

Eligibility Criteria:
Inclusion Criteria:

* Eligibility criteria include being between ages 18-24 and having a family history of depression. Preference will be given in selection of participants to those of who have not been treated for depression in the past.

Exclusion Criteria:

* Moderate or greater risk of having depression (CESD score \> 16) or current treatment for depression. Those who have a history of past treatment of depression will not be excluded.
Evaluation of Satisfaction in Patients Undergoing Non Surgical Lifting by Means of Coned Wires.

An email questionnaire about subjective satisfaction and discomfort has been sent to 243 patients undergoing non-surgical facial and cervical lift 1 week, 1 month, 6 months and 1 year after treatment.

243 patients underwent non-surgical coned wires (silhouette soft) facial and cervical lift between October 2013 and November 2014. The procedures has been executed in our aesthetic clinics in Milan, Bologna, Turin, Genoa, Rome, Asti, San Remo and Palermo.

Among the 243 patients, 217 were females and 26 males, with age ranging from 19 to 76 years. 103 patients underwent only facial lift, of which 12 only in the frontal area, 61 only on cheek and malar area, and 30 on both the areas.

39 patients underwent only cervical lift, of those 14 by means of appliance of 1 or 2 wires, 25 by means of appliance of more than 2 wires.

101 patients underwent both facial and cervical non surgical lift. We sent to every patient a email questionnaire1 week, 1 month, 6 months and 1 year after treatment.

In the questionnaire, patients has been asked to enter a value between 1 and 5 about subjective satisfaction regarding the aesthetic improvement (ranging from 1, poor, to 5, excellent), and discomfort related to treatment (ranging from 1, no perceived discomfort, to 5, impossibility to execute working and social activities).

The data has been analyzed and related to other factors such as:

* number of wires applied on each patient
* other aesthetic or regenerative medicine treatments executed on the same patient on the same year
* total expenditure related to aesthetic treatments in the same year

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing facial and cervical non surgical lift by means of resorbable coned wires

Exclusion Criteria:

* Patients with asymmetry
The Effect of Patients' Participation in Improving Diabetes Care

Despite the advent of efficacious medicines, there is a gap between ideal and actual care in the achievement of recommended outcomes among diabetic patients. The study enrolled 429 diabetic patients attending four HMO clinics in Israel, two in the northern region and two in the southern region. All clinics were randomly selected from all clinics affiliated with the Faculty of Health Sciences of the Ben Gurion University. The objective of the study was to compare the effects of a multi-component physician-patient intervention to physician feedback alone on a combined outcome of diabetes, blood pressure and serum lipids control. We hypothesized that in medical practices where physicians have received feedback on quality of care indicators, patients who received a letter encouraging them to discuss a list of important diabetes-related issues with their doctors, would experience better outcomes compared to patients who did no received such a letter.


Eligibility Criteria:
Inclusion Criteria:

* Known diabetic patients enrolled in the four primary care clinics
* Age 30 years and older.

Exclusion Criteria:

* Below age 30 years
* Type 1 diabetes
* Spoke neither Hebrew nor Russian
* Bedridden or confined to home.
Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI

The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury

The primary injury occurs at the time of trauma. secondary injury is caused by complications of the primary insult and caused by processes such as hypoxia, cerebral edema and ischemia.

Severe traumatic brain injury is associated with increased intracranial pressure, activation of the sympathetic nervous system and catecholamine response and major morbidity and mortality .

β-blockade is just one pharmacologic strategy to reduce sympathetic hyperactivity. In the Intensive care unit patients with severe traumatic brain injury associated with restlessness and agitation are frequently sedated and intubated in order to reduce the workload of the brain. This hyperactive response is called sympathetic storming which occurs within 24 hours of brain injury or weeks later . It occurs due to acceleration in sympathetic nervous system activity in the central nervous system which results in loss of cortical control due to downregulation of autonomic balance in the brain injury .

A Non-Selective beta-adrenergic antagonist propranolol, is one of the most customarily used treatments in the case of paroxysmal sympathetic hyperactivity.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged between 18and 65 years old
* Patients who have Severe traumatic brain injury
* Glascow outcome scale ≤ 8

Exclusion Criteria:

* Patients have pre-existing heart disease.
* If there are contraindications to β blocker.
* penetrating traumatic brain injury.
* pre-injury brain dysfunction.
* β-blocker or α2-agonist use before trauma.
Comparison of TUSP Versus TURP for Treatment of Benign Prostatic Hyperplasia in a Small Prostate Volume

Comparison of transurethral split of the prostate versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia in a small prostate volume: A prospective controlled study

Transurethral resection of the prostate (TURP) was considered as the golden standard to treat benign prostatic hyperplasia (BPH) for decades. However, TURP was associated with low efficiency to alleviate the lower urinary tract symptoms and a significantly higher risk of bladder neck contracture (BNC) for patients with small-volume BPH. We aimed to compare the therapeutic effect of transurethral split of the prostate (TUSP) with TURP for patients with small-volume BPH (\<30 ml).

In this study, some selected small-volume BPH patients were randomly divided into two groups (TUSP and TURP group). The patient's baseline characteristics and perioperative outcomes were recorded. The follow-up was made at 6 months, 1 year and 2 years after surgical treatment.

Eligibility Criteria:
Inclusion Criteria:

* Benign prostatic hyperplasia patients with surgical indication
* Maximum flow rate \<12ml/s
* Prostate volume \<30ml
* The international prostate symptoms score\>21
* Medication of α-adrenergic blockers for at least 3 months

Exclusion Criteria:

* Acute prostatitis and urethritis
* Neurogenic bladder
* Abnormal prostate-specific antigen level
* Urethral injury history
Effect of Topical Anesthesia on Patient's Pain Discomfort and Radial Artery Spasm in Transradial Catheterization

This study evaluate topical anaesthesia application for 30 minutes before tranradial catheterization during cardiac catheterization can reduce pain and decrease radial artery spasm

The incidence of Radial artery spasm (RAS) has varied from 5-30% RAS refers to friction between the artery and wires or guide catheters accompanied by a subjective feeling of pain.

EMLA anesthetic ointment (AO-Astra Zeneca) is an emulsion of lidocaine 2.5% and prilocaine 2.5% in a ratio of 1:1 by weight Previous study showed that EMLA cream can increase the success rate of femoral cannulation in children.

Eligibility Criteria:
Inclusion Criteria:

* Patients age \>18 years.
* Patients who was schedule to performed coronary angiogram

Exclusion Criteria:

Previous ipsilateral transradial approach Raynaud's syndrome ESRD History of sensitivity to local anesthetics Non-palpable redial pulse Abnormal Barbeau's test Local site infection Patient's refusal
A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis

The study objective is to investigate the efficacy of levocetirizine in reducing symptoms associated with seasonal allergic rhinitis and in improving rhinitis-related Quality of Life


Eligibility Criteria:
Inclusion Criteria:

* Subjects with a history of SAR symptoms
* A positive skin prick test at least one grass allergen
* Moderate - severe SAR symptoms at baseline
* Women of childbearing potential must use a medically acceptable form of contraception
* 80% compliance on run in study medication and 80% compliance on completing the diary

Exclusion Criteria:

* The presence of any clinically significant comorbid disease which may interfere with the study assessments
* The presence of renal disease
* Pregnant or breastfeeding
* Subject is currently participating in another clinical trial
* Known hypersensitivity to piperazines or any of the excipients
* Intake of medications prohibited before the start of the trial
* Subjects who started or changed the dose of immunotherapy
* Rhinitis medicamentosa
* Subjects with a recent history (within the last 2 years) of drug or alcohol abuse.
Histological Improvement of NASH With Prebiotic

This trial will investigate the therapeutic potential of a prebiotic supplement to improve histological parameters of NASH. In a single-blind, placebo controlled, randomized pilot trial will be conduced in individuals with liver biopsy confirmed NASH (Non-alcoholic fatty liver activity score (NAS) ≥ 5). Participants will be randomized to receive oligofructose (8 g/day for 12 weeks and 16g/day for 24 weeks) or isocaloric placebo for 9 months. The primary outcome measure is the change in liver biopsy NAS score and the secondary outcomes include changes in body weight, body composition, glucose tolerance, serum lipids, inflammatory markers, and gut microbiota.

Oligofructose and maltodextrin are both white powders that taste and look the same. They were both package in individual foil packets. Participants were blinded to the treatment allocation. Adherence to supplement protocol was monitored throughout the study through direct questioning and counting unused supplement packages. Participants were asked to maintain their usual physical activity.

Eligibility Criteria:
Inclusion Criteria:

* Liver biopsy confirmed NASH (NAS score greater than or equal to 5)
* BMI \>25 kg/m2 (Caucasians)
* \>23 kg/m2 (Asians)
* History of Serum ALT \>1.5X upper normal limit
* No changes in lipid-lowering or diabetes medication over previous three months
* Ability to provide informed consent

Exclusion Criteria:

* alcohol consumption \>20g/day (women) or \>30g/day (men)
* alternate etiology for abnormal liver enzymes
* decompensated liver disease
* use of orlistat, liraglutide, prebiotic, probiotic, or antibiotic within 3 months prior to enrollment