cyrilzakka/clinical-trials huggingface dataset:
Different Resistance Training Intensity Prescription and Monitoring Methodologies: Effects on Strength, Body Composition, and Well-being in Survivors of Breast Cancer

The goal of this clinical trial is to compare the effects of three different methods of prescribing and monitoring resistance training intensity on muscle strength, body composition, quality of life, fatigue, anxiety, and depression in breast cancer survivors.

Breast cancer survival rates have significantly increased in recent years, highlighting the importance of effective interventions to address the long-term consequences of cancer and its treatments. Breast cancer survivors often experience muscle weakness, changes in body composition, fatigue, and psychological distress, which can negatively impact their quality of life. Resistance training has been widely recognized as a safe and effective strategy to counteract these effects, improving muscle strength, body composition, and psychological well-being.

Despite its benefits, the optimal method for prescribing and monitoring resistance training intensity in breast cancer survivors remains unclear. Traditional methods based on one-repetition maximum (1RM) testing may not fully account for individual variations in fatigue and performance. Alternative approaches, such as load-velocity relationships, allow for more precise and real-time adjustments to training intensity, potentially optimizing outcomes.

This randomized controlled trial aims to compare the effects of three different methods of resistance training intensity prescription and monitoring on muscle strength, body composition, quality of life, fatigue, anxiety, and depression in breast cancer survivors. The findings will contribute to developing evidence-based exercise guidelines, enhancing rehabilitation strategies and overall well-being in this population.

Eligibility Criteria:
Inclusion Criteria:

* To be \>18 years old.
* To have a breast cancer diagnosis.
* To have finished chemotherapy, radiotherapy and/or surgery up to 10 years prior to the beginning of the study.

Exclusion Criteria:

* To present metastatic breast cancer.
* To have a planned surgery for breast reconstruction within three months after the start of the study.
* To present any absolute contraindication for exercising.
Point Prevalence of Side Strain in Fast Bowlers and Effectiveness of Core Strength Training.

To find out the prevalence of side strain in fast bowlers and determine the effectiveness of core strength training in treating side strain

A fast bowler needs to have strong core muscles in order to prevent side strain, which can hider the performance. Variation in deliveries , bowling speed and bowling action can be compromised due to side strain injuries specifically in fast bowlers.

A strong and stable core helps to maintain balance and provide strength while performing repetitive movements such as bowling. Core strengthening program should include exercises that are sports specific, conditioning exercises that focus on anterior and posterior musculature of the trunk and hip.

The aim of this study is to find out the prevalence of side strain in fast bowlers and to incorporate strengthening exercises for core muscles to evaluate its effectiveness for side strain.

Eligibility Criteria:
Inclusion Criteria:

* Male fast bowlers
* Age 14 to 40 years

Exclusion Criteria:

* Athletes who have undergone any surgery
* Anyone with history of chest pain due to cardiopulmonary disorders
OsseoFit™ Prospective Data Collection

This study compares the fill of bone graft sites in the knee. It is hypothesized that harvest sites, voids, and defects caused by trauma that are treated with the OsseoFit™ Porous Tissue Matrix™ device will achieve a better fill grade than those treated with the conventional method.


Eligibility Criteria:
Inclusion Criteria:

* The OsseoFit™ Porous Tissue Matrix™ is intended to be gently packed into the bony voids or gaps of the extremities and pelvis caused by trauma or surgery and are not intrinsic to the stability of the bony structure. These defects may be created from repetitive motion or traumatic injury to the bone or surgically created osseous defects for the harvest of bone. The device is a bone void filler that resorbs and is replaced with bone during the healing process. The device may be combined with sterile fluids such as saline or autogenous blood products such as blood, platelets, or bone marrow aspirate. The addition of these autogenous blood products does not compromise the performance of the device. Hydration with biologically beneficial sterile fluids can potentially have a positive influence on the healing and replacement of the device with bone.

Exclusion Criteria:

* Infection at site
* Hypercalcemia
* Known allergies to bovine collagen
* Current osteomyelitis at operative site
* Systemic conditions which affect bone and/or wound healing
* Known severe allergies manifested by history of anaphylaxis
* Desensitization treatment injections to meat products, as injections may contain bovine collagen
* Severe degenerative bone disease
Novel PET/CT Agents and MRS/MRI in Prostate CA and High Risk Prostate Cancer: An Inter-SPORE Collaboration

Prostate cancer imaging using traditional anatomic modalities including CT, MR, and ultrasound is limited. Improvement in current imaging modalities or development of new ones should be a priority in prostate cancer research. Optimal treatment varies considerably for patients with different staging characterizations and new imaging methods that more accurately stage patients could lead to more appropriate treatment. The objective of this study is to obtain preliminary, comparative data on new, promising imaging methods for prostate cancer. PET/CT imaging using 11C-choline,11C-acetate, and Y86 or 18F-Adenosylcobalamin and MRI spectroscopy (MRS) of prostate cancer will be compared. Direct comparison of these imaging methods has never been done and Mayo Clinic and Johns Hopkins are uniquely able to conduct such a trial as an inter-SPORE collaboration.


Eligibility Criteria:
Inclusion Criteria:

* Males 18 years of age or older
* Patients who have completed staging CT and/or bone scan as part of their routine workup
* Patients with bulky metastatic prostate cancer who have 5 or more lesions suspicious for distant metastases as determined by routine CT and/or bone scans that are untreated by radiation

Exclusion Criteria:

* Patients who are less than 6 weeks post operative for Greenfield filter placement
* Patients with metallic surgical implants including pacemaker implants, cochlear implants, dentures held in place by magnets imbedded in the gums and aneurysm clips except those inserted at Mayo and only those inserted after October of 1994 and /or metal fragments in the body including metal fragments in the eyes
Dermacyd PH_DETINBACK Tangerine Mix (Lactic Acid) - Safety.

The purpose of this study is to prove the safety in normal conditions of useof the product Dermacyd PH_DETINBACK Tangerine Mix (Lactic Acid).


Eligibility Criteria:
Inclusion criteria:

* Age between 10 and 20 years old;
* Integral skin test in the region;
* Use of cosmetic product of the same category;
* Willingness in following the study procedures and to be present in the clinic at the days and scheduled time;

Exclusion criteria:

* Lactation or gestational risk or gestation;
* Use of Anti-inflammatory, immunosuppression or antihistaminic drugs;
* Atopic antecedent or allergic to cosmetic product;
* Active cutaneous disease in the evaluation area;
* Diseases which cause immunology decrease, such as diabetes and HIV;
* Endocrinal pathologies;
* Intense solar exposure 15 days before the evaluation;
* Treatment until four months before the selection;

The above information is not intended to contain all considerations relevant to a patient¿s potential participation in a clinical trial.
Pain Neuroscience Education as Treatment in Fibromyalgia Affected Patients

Fibromyalgia (FM) is a chronic, complex and disabling clinical entity that has an average global prevalence of 2.7%. It occurs mainly in women in a 3: 1 ratio. It is characterized by persistent generalized pain, fatigue, unrefreshing sleep, cognitive dysfunction and numerous systemic symptoms such as dizziness, migraine, digestive alterations or sensory intolerances. At present there is no pharmacological treatment with specific indication for fibromyalgia. Usually, non-curative treatments are recommended that alleviate the symptoms of the patients and improve their quality of life and functionality.

The investigator's main goal is to evaluate the effectiveness at 1 year of a group educational intervention in neurobiology of pain in patients affected by fibromyalgia, in comparison with the evolution of a control group that will continue only with its usual treatments. This intervention will be carried out in the field of Primary Care and its effectiveness will be assessed by reducing or not having diagnostic criteria (reduction of areas of pain and of the severity of fibromyalgia symptoms), using the Criteria for the Diagnosis of Fibromyalgia of the American College of Rheumatology 2010 (ACR 2010).

Methodology of the project In group sessions of 14 patients, a health professional explained the neurological mechanisms that are behind the perception of pain, fatigue and illness from the recent knowledge in neuroscience about brain and pain, as well as the brain's ability to change patien´s behaviour thanks to neuroplasticity.

There will be 5 sessions of 2 hours per week and another one per month. Before the latter, a workshop of 2 hours of movement will be given.

Each week the contents of the class and other complementary materials will be sent to the patients.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of fibromyalgia stablished by the American Rheumatology College criteria 2010,
* Older than 18 years
* Have signed the informed consent

Exclusion Criteria:

* Psychiatric or neurological disorder which could prevent assimilate the training
* Refusal to participate in the trial
Clinical Evaluation of BioFlx Crowns and Preformed Zirconia Crowns on Primary Second Molars

The goal of this clinical trial is to clinically evaluate the performance of BioFlx in comparison to preformed zirconia crowns in the restoration of primary second molars in pediatric patients.

The main questions it aims to answer are:

Is there a difference between BioFlx crowns (Group A) and one zirconia (Group B) in terms of crown retention (primary outcome)? Is there a difference between BioFlx crowns (Group A) and one zirconia (Group B) in modified gingival index, plaque index, occlusion, surface roughness, stain resistance, wear of opposing tooth, color match, anatomic form, marginal integrity and discoloration, proximal contact, and recurrent caries at the crown margins?

Researchers will compare the clinical performance of Bioflx crowns and zirconia crowns to determine if they are similar.

Participants:

* Participants will be asked to attend two appointments. During the first visit, a BioFlx crown will be placed on the primary lower second molar, and during the second visit, a zirconia crown will be placed on the contralateral primary lower second molar.
* Participants will be recalled and evaluated after 3, 6, and 12 months.


Eligibility Criteria:
Inclusion Criteria:

* Children aged 5-9 years old.
* American Society of Anesthesiologists Classification I or II status.
* Cooperative child.
* Obtained informed consent.
* Two primary lower second molars requiring full coverage restorations.
* Primary lower second molars in functional occlusion with the opposing tooth and have at least one contact area with an adjacent tooth.
* Primary lower second molars that can be adequately isolated.
* Pulptomized primary lower second molars.
* Primary lower second molars with multi-surface caries.

Exclusion Criteria:

* American Society of Anesthesiologists Classification higher or equal to three statuses.
* Informed consent is not obtained.
* Allergy to local anesthesia.
* Non-restorable primary lower second molars.
Myoring Versus Keraring Implantation for Keratoconus

Various approaches, including surgical and non-surgical management have been proposed for keratoconus. One of the surgical procedures is Intrastromal Corneal Ring implantations that have been designed to achieve refractive readjustment by flattening the cornea. There are different models of Intrastromal Corneal rings available: intrastromal corneal ring segments (ICRS) such as Keraring and intrastromal corneal continuous ring (ICCR) like Myoring.

Most studies of these two types of ring implantation outcomes are retrospective case series. Thus, this Randomized Clinical Trial study was designed with the aim of Comparing visual and refractive outcomes and complications of insertion Myoring versus Keraring using Femtosecond laser. Keratoconus patients with compound myopic astigmatism who meet the inclusion criteria will randomly allocated to the Keraring and Myoring groups. Subsequently, the clinical outcomes of two groups will be compared at one,3 and 6 months after surgery.


Eligibility Criteria:
Inclusion Criteria:

* keratoconus patients and :
* age between 20 to 40
* corneal thickness\> 380 microns
* mean keratometry between 44 to 60 D
* clear central cornea
* Patients should be discontinued their contact lenses for 3 weeks prior to the exams
* contact lenses in tolerance
* 20/200\<visual acuity \<20/30

Exclusion Criteria:

* Positive pregnancy test
* Breast-feeding
* History of glaucoma, cataract, vernal and atopic keratoconjunctivitis
* History of previous ophthalmologic surgery, keratorefractive surgery on the operative eye
* Dry eye
* Corneal stromal disorders
* History of herpetic keratitis
* Pellucid marginal degeneration
* Corneal grafts
* Retinal disorders
* Nystagmus and uncooperative disposition
* Neuro-ophthalmologic disorders
* Intraocular pressure \<10 mmHg or \>21 mmHg
* Patients with autoimmune, connective tissue disorders, diabetes and immunosuppressive drugs users
* Hyperopia
Trial and Follow-up of the Efficacy of Two-stage Integrated Treatment for Chinese Schizophrenia Inpatients

Regular psychosocial intervention combined with antipsychotic drugs, compared with usual medication alone treatments, can reduce psychiatric symptoms and improve quality of life in patients with schizophrenia. However, it's expensive, time-consuming, and sometimes inconvenient for patients and their family members in developing areas where the number of well-trained therapist remains limited in local psychiatric settings. The investigators aimed to establish an efficient model of integrated treatment (IT) for patients with schizophrenia. The procedure contains two stages: a centralized treatment during hospitalization and the following consolidation treatments with long intervals.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with the Structured Clinical Interview for DSM-IV (SCID-DSM-IV) (First et al., 1996), were recruited from inpatient psychiatric ward. Patients with diagnoses of schizoaffective or other psychotic disorders were not included.
* Additional inclusion criteria for participants were aged between 18 and 50 years with education of more than 9 years, and
* PANSS (Positive and Negative Syndrome Scale) total scores of more than 60.

Exclusion Criteria:

* Diagnosed with a serious and unstable medical condition including abuse and/or dependence of alcohol and/or drugs;
* Pregnant or breastfeeding;
* Under a treatment of clozapine with a dose of more than 200 mg/day,
* Had a treatment of the electroconvulsive therapy (ECT) or modified electroconvulsive therapy within 6 months(MECT) within the past six months.
Influence of Probiotics on Atopy With Focus on Respiratory Allergic Diseases- Follow-up to 7 Years

The investigators had conducted an initial double-blind, placebo-controlled clinical trial (NCT00318695) to study the effects of probiotic supplementation from birth to 6 months of age in the incidence of atopic diseases at 2 years old. This is then further investigated up to 5 years of age in a follow-up study NCT00365469 to assess the longer term beneficial effects.

This current study intends to follow-up for another 2 years until 7 years of age as this is critical in the evaluation of respiratory allergies in the form of clinical asthma and allergic rhinitis.

This study intends to continue the initial double-blind, placebo-controlled randomized clinical trial (NCT00318695) which involved 253 subjects with a first degree family history of allergic disease. The infants received at least 60ml of commercially available cow's milk based infant formula with or without probiotic supplementation (Bifidobacterium longum \[BL999\] 1×10\*7 colony-forming unit (cfu)/g and Lactobacillus rhamnosus \[LPR\]2×10\*7 cfu/g) daily from the first day of life for the first 6 months. A follow-up study (NCT00365469) up to 5 years of age is currently in process.

This current study plans to continue the follow-up for a further 2 years till the cohort reaches 7 years of age. This study will only involve telephone calls which will be conducted every 3 months to ascertain for symptoms and incidence of respiratory allergic disease.This is critical in the evaluation of asthma and allergic rhinitis which tend to develop later in life and this step-wise, temporal development of respiratory allergies has been described as "Atopic March".

Eligibility Criteria:
Inclusion Criteria:

* Subject has completed the both NCT00318695 and NCT00365469 studies.
* Parent(s) / Guardian consent to the subject's participation in the study.
* Subject and the parent(s)/ guardian are willing to comply with the study procedures

Exclusion Criteria:

* The parent is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained.
* The parent is unable/ unwilling to comply with study procedures
Endometriosis and Risk of Miscarriage

The aim of this study is to compare the rate of miscarriage at first spontaneous pregnancy among women with endometriosis with the rate of miscarriage at first spontaneous pregnancy among women without endometriosis.

All women followed up for a surgical or sonographic diagnosis of endometriosis in 11 italian referral Centres for the treatment of endometriosis completed a questionnaire regarding their previous pregnancies. The same questionnaire was completed by women, attending a routine gynecologic visit, in whom surgery or vaginal examination and pelvic ultrasonography excluded endometriosis.

Eligibility Criteria:
Inclusion Criteria:

* 30 to 50 years old women
* with at least one previous spontaneous pregnancy
* with surgical or clinical/sonographic diagnosis of endometriosis or
* in whom surgical or clinical/sonographic evaluation ruled out endometriosis

Exclusion Criteria:

* Pregnancy achieved by Assisted Reproductive technology
* Biochemical pregnancy
* Non corrected uterine malformation, poliabortivity, lupus like anticoagulant
Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 12 Years of Age

To investigate the safety and tolerability of dabigatran etexilate solution in children and to obtain preliminary pharmacokinetic/pharmacodynamic data

Purpose:

Eligibility Criteria:
Inclusion criteria:

1. males or females 1 to less than 12 years of age
2. objective diagnosis of primary VTE
3. completion of planned treatment course with LMWH or OAC for primary VTE
4. written informed consent by parent (legal guardian) and patient assent (if applicable)

Exclusion criteria:

1. weight less than 9 kg
2. conditions associated with increased risk of bleeding
3. patients who have any condition that would not allow safe participation in study Note: Further exclusion criteria apply
Respiratory Complications Among Living Liver-donors

Recently, there are increasing reports about pulmonary complications within living liver donors postoperatively. In this retrospective study, the investigators will highlight the risk factors and incidence of pulmonary complication among living liver-donors in our center.


Eligibility Criteria:
Inclusion Criteria:

* Excellent general physical and mental condition,
* Free of chronic disease or
* Previous major abdominal surgery,
* Body mass index (BMI) \<28,
* ABO blood group identical to recipients and
* Negative for hepatitis B, C and human immunodeficiency viruses (HIV).

Exclusion Criteria:

* ASA physical status\> II,
* BMI\>28,
* Psychiatric or mental retardation,
* pregnant and nursing women or
* Patients with significant laboratory abnormalities
Assessing the Impact of the COVID-19 Lockdown on Metabolic Control and Access to Health Care in Patients With Diabetes

The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the COVID-19 (Coronavirus Disease-2019) in December 2019 has led to an unprecedented international health situation. Exceptional measures have been taken by public authorities worldwide in order to slow the spread of the virus and prevent healthcare systems from becoming overloaded. In France, a national lockdown has been established during approximately 2 months to increase social distancing and restrict population movements. Hospital routine care appointments have been cancelled, in order to reallocate medical resources towards COVID-19 units and limit contacts between patients within hospitals or waiting rooms. While the virus itself, the disease and potential treatments are currently extensively studied, little data are available on the effect of these public health decisions on the management of a chronic condition such as diabetes.

The French regional CONFI-DIAB study aims at assessing the collateral impact of routine care cancellation during the national lockdown due to COVID-19 in patients with a chronic condition such as diabetes. Special attention will be given to metabolic control and access to health care.

This cross-sectional study should provide information on the consequences of a global lockdown and the associated routine care cancellation on the management of diabetes, and inform future decision making in the event of a new pandemic.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients
* Patient with diabetes known for at least 6 months before inclusion
* Patient followed by a specialist physician from the University Hospital of Nancy for routine care within the 6 months prior to the lockdown.
* Patient who was assessed for prioritization of care following the end of the lockdown by the department of endocrinology, diabetology and nutrition

Exclusion Criteria:

* Subjects opposed to the use of their data
* Minors, adults under guardianship, protected persons