cyrilzakka/clinical-trials huggingface dataset:
THE EFFICIENCY OF TECHNOLOGY-BASED MOTIVATION EDUCATION ON OBESITY UNIVERSITY STUDENTS' WEIGHT MANAGEMENT.

The aim of this study is to determine the effects of technology-based motivation education prepared according to the health belief model on obesity-related beliefs and attitudes, nutrition-exercise behaviors, self-efficacy and weight management in obese university students.

It is stated that the university period is risky in terms of acquiring negative health behaviors that may cause overweight and obesity. In addition, it is emphasized that the transition from overweight to obesity usually occurs between the ages of 18-29. There are non-formal education programs on obesity management for adolescence and adulthood. It is noteworthy that young people in the university period are not adequately represented in the current education programs, and at the same time, education programs specific to young people are limited. The aim of this study is to determine the effects of technology-based motivation education prepared according to the health belief model on obesity-related beliefs and attitudes, nutrition-exercise behaviors, self-efficacy and weight management in obese university students. This quasi-experimental pretest-posttest randomized controlled study will be carried out at Sivas Cumhuriyet University Suşehri Health College and Suşehri Timur Karabal Vocational School between February 1, 2022 and September 15, 2022. The sample of the study will consist of 84 students (experimental group n= 42 and control group n=42). A web-based technology based motivation program including motivational interviewing will be applied to the students in the experimental group. The control group will only receive web-based education on obesity. Data will be collected using Personal Information Form, Obesity Health Belief Model Scale, Nutrition-Exercise Behavior Scale, Self-Efficacy-Efficacy Scale and Website Usability Scale. physical measurements; A digital height-weight meter will be used for BMI measurement, and a tape measure will be used for waist and hip circumference. Whether the data is normal or not will be determined by Kolmogorov-Smirnov, Shapiro Wilk tests. In order to determine whether there is a difference in the research, necessary parametric and nonparametric tests will be used depending on whether the assumptions are met or any or all of the assumptions are not met.

Eligibility Criteria:
Inclusion Criteria:

* 18-25 age range
* Body Mass Index (BMI) ≥ 25.0,
* Having internet access with a computer, tablet or mobile device.

Exclusion Criteria:

* Under 18 years old or over 25 years old,
* BMI \< 25.0,
* Continuously using regular medication,
* Presence of a pre-existing health problem (having a surgical operation in the last three months, having diseases with metabolic syndrome, being diagnosed with cancer, being diagnosed with an eating disorder, being diagnosed with a psychological illness, and being physically disabled),
* Participating in any weight management program in the last three months,
* Pregnancy.
Team Elements Associated With Mortality in Intensive Care

The individual characteristics and interactions of health care workers in intensive care units may influence patient safety. This study aims to quantify the influence of team familiarity among the members of medical and nursing staffs on risk of patient death.


Eligibility Criteria:
Inclusion Criteria:

* All patients who were admitted to 9 French intensive care units from January 1st 2011 to December 31st 2016

Exclusion Criteria:

* Patients admitted in pediatrics intensive care units and in specialized burns units
The Effect of Mobile Health-Education Application on Healthy Lifestyle Behaviors in Patients Planned for Bariatric Surgery

Obesity, which is the second leading cause of preventable death in the world, affects all the systems in the body and affects many physiological problems, as well as the mental state, body image and quality of life of the individual. For this reason, obese individuals try various treatment methods in order to get rid of obesity, and in cases where these methods fail, they often prefer bariatric surgery. It is very important that patients who will undergo bariatric surgery can adapt to the anatomical changes in their body and shape their lifestyle accordingly. Otherwise, it is inevitable for patients to face various complications after surgery. After bariatric surgery, a structured training program in the preoperative period is of great importance in order for the patient to adapt to the changes in his body, to prevent the development of possible complications, to be affected by the negativities that may occur due to the current change, and to prepare for the new lifestyle. In this context, the main subject of this research is to enable individuals to gain healthy lifestyle behaviors by providing mobile-based training and consultancy services that enable them to easily access the right information at the desired time and place.


Eligibility Criteria:
Inclusion Criteria:

* Being literate,
* Being able to understand, speak Turkish and not have a hearing impairment,
* First time to undergo bariatric surgery,
* Absence of any psychiatric disorder that will reduce the ability to comprehend and understand,
* Ability to use Android-based smartphones,
* Agreeing to participate in the research.

Exclusion Criteria:

* Patient's desire to quit the study
Learning Effective Approaches to Prevention

The objective of the study is to test the effectiveness, implementation quality, and cost effectiveness of family-based treatment services for adolescent substance abuse delivered in an agency setting.

Despite the success of family-based ecological interventions (FBEI) in controlled trials, this highly promising services approach has not been tested under pure field conditions with ASA populations. Controlled effectiveness research invariably enhances training, supervision, and service delivery conditions in partnering sites in an effort to ensure treatment adherence and consistency. An alternative strategy for advancing dissemination science is rigorous naturalistic research on community clinics that already implement evidence-based practices in the course of routine care. The proposed study will follow this "bottom up" strategy by investigating the quality and impact of ASA services delivered by front-line therapists in a community-based mental health center that already features FBEI as the routine standard of care. The study will use a randomized design to compare naturalistic FBEI services to services as usual (SAU) for ASA. Participants (N = 260) will be recruited from local high schools, enrichment programs, and juvenile justice programs. Eligible adolescents will meet ASAM criteria for outpatient treatment. The SAU condition will contain the three most common service venues for ASA in urban communities: hospital-based ambulatory mental health clinics, drug counseling/addictions specialty clinics, and community mental health centers. The primary aims of the study are to examine the effectiveness of FBEI versus SAU and to compare the strength of FBEI adherence and outcomes to performance benchmarks set during a previous FBEI Stage II efficacy trial. The secondary aims are to compare cost effectiveness, services utilization, and consumer satisfaction in FBEI versus SAU. A multitrait, multimethod assessment design will include adolescent and parent interviews at baseline and 3, 6, and 12 months follow-up. Cost and service utilization data will be collected from self report and from provider agencies in both conditions. The study will yield the first evidence on whether a widely endorsed treatment approach for ASA is potent and feasible in real-world conditions and superior to SAU in outcomes and cost-benefit. An important secondary yield will be increasing the scarce knowledge base on commonly practiced community approaches in the SAU condition.

Eligibility Criteria:
Inclusion Criteria:

1. ages 13 and 17,
2. have a caregiver willing to participate in treatment,
3. meet ASAM criteria for outpatient or intensive outpatient substance abuse treatment,
4. not receiving any other behavioral treatment, and
5. have public or private health benefits that meet standard community clinic registration requirements.

Exclusion Criteria:

1. mental retardation,
2. pervasive developmental disorder,
3. medical or psychiatric illness requiring hospitalization,
4. current psychotic features, or
5. current suicidality (Ideation + Plan + High Intention).
Ayurvedic Nutritional Counseling for Patients With IBS in Comparison to Conventional Nutritional Counseling

The main goal of this randomized controlled clinical study is to evaluate the efficacy of an individual Ayurvedic nutritional counseling (according to tradition) compared to an individual conventional dietary advice (according to the German Nutrition Society - DGE) in patients with irritable bowel syndrome. It is to be investigated whether nutritional therapy elements, which patients can self-implement independently in the home environment, can achieve sustainable therapy effects.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis "irritable bowel syndrome" according to the ROM-III criteria and the German S3 guideline (Layer 2011)
* Female and male patients between 18 and 70 years of age
* Declaration of consent

Exclusion Criteria:

* Bad general condition
* Serious acute or chronic comorbidity
* Pregnancy and breast feeding period
* Eating disorder
* In recognition procedures for early retirement or disability
* Simultaneous participation in another clinical trial
* Participation in a clinical trial within the last 3 months before enrollment
Effects of Remote Ischemic Conditioning on Myocardial Perfusion in Humans

Cardiovascular disease is the second leading cause of death in Denmark, and ischemic heart disease accounts for the bulk of it. The purpose of this study is to clarify whether a mechanical method of remote ischemic conditioning in the form of short-term obstruction of the blood supply to the arm, can improve the heart's blood supply in patients with ischemic heart disease. This will be attempted through experiments on patients with ischemic heart disease and experimental animal studies with simulated cardiovascular disease.

This study will help to clarify whether remote ischemic preconditioning can be used to treat patients with ischemic heart disease.


Eligibility Criteria:
Inclusion Criteria:

* Patients referred for routine myocardial Rb82-PET scanning at Dept. of Nuclear Medicine \& PET center, Aarhus University Hospital, Skejby, Denmark.
* Able to understand the written patient information and to give informed consent.

Exclusion Criteria:

* Patients not undergoing Rb82-PET with adenosine stress test.
* Strenuous exercise (running, bicycling, fitness), intake of beta-blockers or alcohol intake on the day before and on the day of investigation.
* Pregnant/nursing women.
* Fertile women not using contraceptives.
* Patients in dialysis treatment.
* Other concomitant disease or treatment that according to the investigator's assessment makes the patient unsuitable for study participation.
* Known type 2 diabetes
Methodological Issues and Laser Speckle Contrast Imaging

Microcirculation, especially skin microcirculation, is a window towards systemic vascular function in magnitude and underlying mechanisms. Different techniques have been developed to assess the microcirculation. Among these techniques, laser technology is used to perform non-invasive microvascular assessments. Although this technique is widely used, different methodological issues remain. This study aims at defining the way to use lasers for clinical use.


Eligibility Criteria:
Inclusion Criteria:

* age \> 18years old
* subject without any known cardiovascular disease

Exclusion Criteria:

* pregnancy
Maintenance Treatment of Iron Deficiency in IBD Patients

The aim of this study is to evaluate the treatment of iron deficiency in IBD patients.


Eligibility Criteria:
Inclusion Criteria

Non-anaemic patients treated in the FERGI-CORRECTION study (Hb ≥12 g/dL female, ≥13 g/dL male), independent of ferritin value.

Females of child-bearing potential must have a negative urine pregnancy test at screening and be practising an acceptable method of birth control during the study and for up to 1 month after the last dose of study medication.

Exclusion Criteria:

Chronic alcohol abuse (alcohol consumption \>20 g/day).

Presence of portal hypertension with oesophageal varices. History of erythropoietin, intravenous or oral iron therapy, or blood transfusion in 12 weeks prior to screening.

Known hypersensitivity to FERINJECT®.

History of acquired iron overload.

Myelodysplastic syndrome.

Pregnancy or lactation.

Known active infection, clinically significant overt bleeding, active malignancy. Known chronic renal failure.

Surgery with relevant blood loss (defined as Hb drop \<2 g/dL) in the 3 months prior to screening or planned surgery within the following 3 months.

Chronic liver disease or increase of liver enzymes (alanine aminotransferase (\[ALT\], aspartate aminotransferase \[AST\]) \>3 times the upper limit of normal range.

Known human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.

Inability to fully comprehend and/or perform study procedures in the investigator's opinion.

Participation in any other interventional study (except correction study) within 1 month prior to screening.

Body weight \<35 kg.

Significant cardiovascular disease, including myocardial infarction within 12 months prior to study inclusion, congestive heart failure NYHA (New York Heart Association) grade III or IV, or poorly controlled hypertension according to the judgment of the investigator.
Addressing School-related Gender-based Violence as Part of the Keeping Girls in School Initiative in Zambia

The objective of this mixed-methods study is to evaluate the effectiveness of a school-based safe-space program delivered to secondary school students in Zambia. The quantitative component of the study uses a randomized controlled trial to measure changes in students' experience of school-related gender-based violence (SRGBV), attitudes towards gender and SRGBV, socio-emotional well-being, and school climate, among other outcomes. Meanwhile, the qualitative component of the study aims to understand the prevailing norms around SRGBV in schools, the perception of the intervention and its impact, and the potential mechanisms through which the intervention generates its outcomes.

This study will evaluate the impact of the Empowerment Pilot, a school-based safe-space program delivered to secondary school students in Zambia, implemented between May and November 2023. The main question it aims to answer is whether the Empowerment Pilot changes attitudes and norms around gender roles and school-related gender-based violence (SRGBV), increases socio-emotional well-being, improves school climate, and reduces SRGBV. We use a mixed-methods triangulation design and combined qualitative and quantitative approaches in data collection and analysis to enhance the validity, depth, and relevance of our findings. Data will be collected from approximately 6,000 adolescent girls and boys and their teachers across three districts in Zambia.

The mixed-methods evaluation gives equal importance to the qualitative and quantitative components. However, this registration primarily describes the quantitative component of the study.

Eligibility Criteria:
Inclusion Criteria for Adolescent Participants:

* Students enrolled in grades 8 - 11 of secondary schools in the 2023 school year at the start of the intervention
Reduction of Post Mastectomy Pain With the Jacki® Recovery Jacket

This research study is studying a garment called the Jacki® recovery jacket that can be worn after surgery as a possible way to manage pain from surgical drains.

The study intervention involved in this study is:

-"Jacki" recovery jacket

In this research study, the investigators are studying the Jacki, a garment that can be worn post-mastectomy with pockets that hold post-surgical drains. The Jacki was invented by a cancer survivor who leads A Little Easier Recovery®, a non-profit organization in Massachusetts, and may help participants manage the pain of post-surgical drains to increase comfort and ease of daily living. The jacket has not previously been tested in a research study. The investigators are hoping to learn whether the jacket is effective in reducing pain and discomfort from the time participants leave the hospital until they return to have their drains removed.

Eligibility Criteria:
Inclusion Criteria:

* Patients who are ≥ 18 years old.
* Patients who speak and understand English.
* Patients who have had mastectomy with reconstructive surgery in one or both breasts.

Exclusion Criteria:

* Co-morbid delirium
* Dementia
* Mental illness, or neurocognitive deficit prohibiting informed consent and/or ability to complete study procedures.
Maintenance Intermittent Therapy for Symptomatic GERD Patients

The purpose of this study to determine the efficacy of 20 mg of rabeprazole given as a maintenance intermittent therapy following acute treatment for Symptomatic Gastroesophageal Reflux Disease (s-GERD).


Eligibility Criteria:
Key Inclusion Criteria:

1. Male or female patients, 18 to 65 years of age.
2. If female, not of childbearing potential by reason of surgery, radiation or menopause, or of childbearing potential, but using an approved method of contraception since the last menstrual period, for example, intrauterine device (IUD), implant, double barrier method, or oral contraceptives for at least one cycle. Females of childbearing potential must have a negative urine pregnancy test before medication is dispensed.
3. Patients must report a minimum three-month history of GERD symptoms. GERD symptoms are defined as heartburn with or without regurgitation or other associated GERD symptoms.
4. Patients must have at least 4 days with heartburn per week in each of the 2 weeks prior to Screening.
5. Patients must have no esophagitis, with no proton pump inhibitors (PPIs, prescription or OTC), H2 blockers (prescription or OTC) or prokinetics within 14 days, prior to the endoscopy.

Key Exclusion Criteria:

1. Evidence of significant hepatic, renal, respiratory, endocrine, hematologic, neurologic, psychiatric or cardiovascular system abnormalities, unless the Sponsor and Investigator agree that the nature and severity of any abnormality is unlikely to interfere with the conduct of the study, the interpretation of study results, or the health of the patient during the study.
2. Females must not be pregnant, lactating or have a positive urine eta human chorionic gonadotropin (B-hCG) laboratory result.
3. Patients with a history of allergy or sensitivity to proton pump inhibitors or to their inactive ingredients.
4. Patients with known gastric ulcer, duodenal ulcer, infectious or inflammatory conditions of the small or large intestine, malabsorption syndromes, obstruction, a history of gastrointestinal malignancy, or prior gastric or intestinal surgery (including vagotomy).
5. Patients who have a history of Barrett's esophagus, esophageal stricture, or pyloric stenosis.
6. Patients with a history of endoscopically-proven esophagitis any time in the past.
7. Patients who have taken proton pump inhibitors (PPIs, prescription or OTC), H2 blockers (prescription or OTC) or prokinetics within 14 days, prior to Screening endoscopy, or any of these medications within 7 days prior to the single-blind placebo run-in period.
Non Opioid Treatment for Experimental Dyspnea

The purpose of this protocol is to test the effects of the non opioid nefopam on experimental dyspnea and on the counterirritation (ie inhibition of one pain by another pain) induced by dyspnea in healthy subjects.

Dyspnea and pain share many features. One of them is the counterirritation phenomenon: defined in pain research as the attenuation of one pain by another pain. Dyspnea induced with inspiratory threshold loading (increased sense of work/effort ) has been shown to attenuate electrical pain as shown through nociceptive flexion reflex inhibition, or thermal pain, as measured with cortical evoked responses (laser evoked potentials-LEP).

The investigators will study whether nefopam modulates the counterirritation of laboratory induced dyspnea in healthy subjects. The effect of nefopam on experimental dyspnea will be measured with a visual analog scale (VAS) and a validated multidimensional dyspnea profile (MDP). The effect of treatment on counterirritation will be measured by recording LEP obtained using a CO2 laser system. The amplitude of the N2-P2 component of the LEP is the main study outcome.

Eligibility Criteria:
Inclusion Criteria:

* Healthy
* Non-smoking

Exclusion Criteria:

* acute or chronic pain
* antalgic or psychoactive drugs use
* nefopam hypersensibility
* severe allergy
* diabetes
* glaucoma
* prostate adenoma
* seizure disorder or convulsion history
* heart or circulation disease
* pulmonary disease or asthma
* kidney or liver disease
* brain or nerve disease
* lack of adhesion to no antalgic drug, alcohol, coffee and cola within previous experiment day consumption
The Use of Capnography as a Guide for Oral Intubation

The purpose of this study is to assess if capnography can be utilized to assist in the process of endotracheal intubation; specifically, in locating the glottic opening. Ultimately this would result in a new use of capnography to aid in securing normal and difficult airways. Currently capnography is only utilized for the confirmation of endotracheal tube placement.

If successful, this study will provide information, and allow for the development of instrumentation that will assist in difficult airway management; specifically, in locating the glottic opening when visualization may be impaired. Ultimately, this technique will be useful for routine and emergency airway management.

The purpose of this study is to assess if capnography can be utilized in the process of endotracheal intubation; specifically, in locating the glottic opening. Ultimately this would result in a new use of capnography to aid in securing normal and difficult airways. Currently capnography is only utilized for the confirmation of endotracheal tube placement.

If successful, this study will provide information, and allow for the development of instrumentation that will assist in difficult airway management; specifically, in locating the glottic opening when visualization may be impaired. Ultimately this technique will be useful for routine and emergency airway management.

Eligibility Criteria:
Inclusion Criteria:

* Patients for elective surgery, requiring general endotracheal anesthesia

Exclusion Criteria:

* Patients with a known or suspected difficult intubation
* Patients requiring specialized endotracheal tubes
* Patients with a history of tracheostomy
* Airway tumor or airway pathology