cyrilzakka/clinical-trials huggingface dataset:
68Ga-JH12 PET/CT: Dosimetry and Biodistribution Study

68Ga-JH12 is a novel radiotracer targeting C-X-C motif chemokine receptor 4 (CXCR4). In this study, we observed the safety, biodistribution, and radiation dosimetry of 68Ga-JH12 in patients with different types of cancer.

C-X-C motif chemokine receptor 4 (CXCR4) is highly expressed in patients affected with malignant tumors and ex-vivo analyses provided evidence that the expression level on the tumor cell surface is tightly linked to the proliferation index. In recent years, the diagnostic PET agent 68Ga-Pentixafor targeting this chemokine receptor has been extensively validated in haematological malignancies and solid tumors. 68Ga-JH12, a novel radiopharmaceutical targeting CXCR4, demostrated high stability in vitro and in vivo, and can accumulate specifically in tumors with high binding affinity, safety, and selectivity in preclinical studies. In this study, the safety, biodistribution, and radiation dosimetry of 68Ga-JH12 in patients with Various Cancers were observed to evaluate the dosimetric characteristics of 68Ga-JH12.

Eligibility Criteria:
Inclusion Criteria:

* Various solid tumors with available histopathological findings
* Signed informed consent

Exclusion Criteria:

* pregnant or lactational women
* who suffered from severe hepatic and renal insufficiency
TEP With 68-DOTANOC in Gastroenteropancreatic Neuroendocrine Tumors

Evaluation of the diagnostic performance of PET / CT with 68Ga-DOTANOC in Gastroenteropancreatic Neuroendocrine Tumors with comparison with other techniques used in routine clinical practice (octreoscan ® ; multiphase SPECT / CT, MRI or endoscopy).

Therapeutic impact and safety of PET / CT with 68Ga-DOTANOC will also be assessed. Expected results are a confirmation of the superiority of 68Ga-PET DOTANOC versus scintigraphy octreoscan ®, with a potential impact on the therapeutic management of patients.


Eligibility Criteria:
Inclusion Criteria:

* Age over 18 years
* effective contraception or exclusion of pregnancy dosage of beta-HCG in women of childbearing age
* Fortuitous discovery of suggestive tumors of TE-GEP with well documented conventional imaging (multiphase CT; MRI, US endoscopy) associated or not associated with clinical or biological signs of TE-GEP tumors (increase in tumor markers) OR
* Histologically proven GEP-TE (WHO classification 2010 (26) well differentiated in the initial staging OR
* Suspicion of recurrence or progression of well differentiated TE-GEP tumors on conventional imaging or laboratory tests (increase in tumor markers) OR
* Clinical or biological syndrome strongly suggestive of digestive endocrine disease without identification of lesions with conventional imaging
* Informed consent and patient's written
* Affiliation to an insurance

Exclusion Criteria:

* Multiple endocrine neoplasia
* TE GEP tumor not differentiated
* Pregnancy and lactation
* Persons protected by law
* Restlessness, inability to lie still hold at least 1 hour; Claustrophobia
* Poor compliance predictable or inability to undergo medical test for geographical, social or psychological
* Treatment with radiotherapy, chemotherapy or other antitumor treatment within 6 weeks of previous morphological and scintigraphic examinations. In case of treatment with somatostatin analogues delayed, scans will be performed 4 weeks after the last injection. However, a shorter period may be observed to avoid to do again the initial assessment exams.
* malignancy except basal cell cancers and cancer in situ of the cervix
* Contraindication of injection of a contrast agent necessary for the production of multiphase scanner.
* Patients who had a CT scan without injection of contrast material can not participate in the study
T Cell Response in Hypersensitivity Syndrome

immunological study of the T cell repertoire phenotype and functionality in hypersensitivity syndrome.


Eligibility Criteria:
Inclusion Criteria:

* age \> 18
* cutaneous eruption
* lymph nodes
* hepatitis
* interstitial pneumonia
* nephritis
* cardiopathy
* eosinophilia
* hyperlymphocytosis

Exclusion Criteria:

* age minor to 18
* HIV +
Inhaled BUDESONIDE/FORMOTEROL in Bronchiolitis Obliterans Following Stem Cell Transplantation

The purpose of this study is to determine whether inhaled Budesonide/formoterol is effective in the treatment of bronchiolitis obliterans after allogeneic stem cell transplantation.

Bronchiolitis obliterans (BO) is a life-threatening pulmonary late-onset complication following allogenic stem cell transplantation (SCT), commonly attributed to graft versus host disease (GVHD), and carries a poor prognosis. Although immunosuppressive treatments (IS) represents the main therapeutic approach in this disorder, these medications are rarely efficient and alternative approaches are strongly needed. Because, the combination of inhaled steroids and long-acting bronchodilator are known to decrease respiratory symptoms, prevent exacerbations and improve lung function in chronic obstructive pulmonary diseases with bronchiolar component, they may have beneficial effects in BO. Thus, the investigators conducted a pilot open-labeled trial to evaluate the therapeutic effects of inhaled Budesonide/Formoterol combination (400/12 µg twice a day) without modifying systemic IS received by the patients.

Eligibility Criteria:
Inclusion Criteria:

* adult allogeneic stem cell transplant recipients with clinical respiratory signs assumed to be secondary to BO, without extra-thoracic extensive graft versus host disease

Exclusion Criteria:

* Extensive extra thoracic GVH necessitating increasing immunosuppressive treatments
Evaluation of the Improvement of Primary Prevention in Ischemic Cardiomyopathy Patients Using New Screening and Referring System (Advance-ICM)

The patients who undergo ICD(implantable cardioverter defibrillator) implantation for the primary prevention of sudden cardiac death with severe LV(left ventricle) dysfunction (ejection fraction ≤ 40%) by ICM(idiopathic cardiomyopathy).

Indications for ICD implantation for primary prevention in accordance with 2016 revised Korean indication guideline on ICD implantation

* FU LVEF(Left Ventricular Ejection Fraction) ≤ 30% (at least 40 days post-myocardial infarction)
* FU LVEF 31\~35%, NYHA(the New York Heart Association) class II, III (at least 40 days post-myocardial infarction)
* FU LVEF ≤ 40%, NSVT(non-sustained ventricular tachycardia) (Holter), inducible VF(ventricular flutter) or sustained VT(ventricular tachycardia) at electrophysiological study (at least 40 days post-myocardial infarction)


Eligibility Criteria:
Inclusion Criteria:

* Age 18-80 years
* Patients eligible for the indications for ICD implantation for primary prevention indication in accordance with 2016 revised Korean indication guideline on ICD implantation
* Patients should be managed by non-EP physician
* Patients who are willing to sign the informed consent
* Patients who are willing to receive the implantation and post-operative follow-up

Exclusion Criteria:

* Malignant tumor
* Life expectancy \< 12 months
* Patients unable or unwilling to cooperate in the study procedures
Blood Flow Restriction (BFR) Training on the Ulnar Collateral Ligament (UCL)

The goal of this clinical trial is to identify any differences in elbow ulnar collateral ligament (UCL) relative thickness and joint space laxity in the dominant arm following an 8-week course of low intensity resistance exercises with blood flow restriction (BFR) exercises in healthy volunteers. The main questions it aims to answer are:

1. Do BFR exercises contribute to a change in the relative ligament thickness of the UCL, and changes in the ulnohumeral joint space?
2. Are there changes in arm strength following the 8-week strengthening protocol with/without BFR?

Participants will:

* Complete two BFR sessions a week for a total of eight weeks.
* Complete an exercise session with both arms (dominant arm will receive BFR) at each study visit.
* Have sonographs taken of the UCL at the first and last study visit.
* Complete strength assessments at the first and last study visit.


Eligibility Criteria:
Inclusion Criteria:

* Healthy volunteer
* Agree to complete all exercise sessions and program in its entirety
* Between the ages of 18-50 years old

Exclusion Criteria:

* Current or recent injury of the hand, elbow, or shoulder
* Outside of the ages of 18-50 years old
* Vascular compromise or previous vascular surgery
* History of DVT
* Current participation in other BFR research study
* Currently participating in a structured strength training program
* Any musculoskeletal conditions resulting in inability to exercise
* Participants may not be collegiate/professional baseball/softball players
* Vulnerable populations
Sensory Integration Versus Fine Motor Intervention in Children With Autism

Clinically, infants with Autism spectrum often display gross motor delays in supine, prone, and sitting skills in their first year of life.


Eligibility Criteria:
Inclusion Criteria:

* Age ranges from 8 to 12 years.
* Mild to moderate autistic features

Exclusion Criteria:

• Significant visual or auditory defects.
Pattern and Type of Amputation and Mortality Rate Associated With Diabetic Foot in Jeddah, Saudi Arabia: A Retrospective Cohort Study

This study explored the pattern and type of amputations performed on patients with diabetic foot who were admitted to our institution, as well as the 7-year mortality rate of patients with diabetic foot at the same institution. We believe that our study makes a significant contribution to the literature because it highlights the need for strengthening efforts to decrease the risk of amputation and mortality among patients with diabetic foot, especially in Jeddah, Saudi Arabia.


Eligibility Criteria:
Inclusion Criteria:

* From the medical records of King Abdulaziz University Hospital (KAUH).

Exclusion Criteria:

* None
The Effect of a Brief Intervention on Anthropometric and Metabolic Variables

This study will evaluate the effect of a brief intervention on anthropometric and metabolic changes in overweight women with low health literacy. The total number of samples was determined as 88. It was decided to recruit a total of 124 people, 62 people in each group, with a 40% loss in the groups. Brief intervention interviews will be conducted with the intervention group. Brief intervention interviews will take an average of 20-30 minutes and four times. The control group will not be intervened except for the first and last evaluations.

This study will evaluate the effect of a brief intervention on anthropometric and metabolic changes in overweight women with low health literacy. The total number of samples was determined as 88, 44 in each of the intervention and control groups. It was decided to recruit a total of 124 people, 62 people in each group, with a 40% loss in the groups. Randomization will be performed after obtaining consent from the participants who meet the eligibility and exclusion criteria. The sampled individuals will be assigned to the Intervention and Control groups according to the block randomization method. Brief intervention interviews will be conducted with the intervention group. It was determined as the first evaluation and the follow-ups on the 1st day, 15th day, 1st month, 3rd month, and the last evaluation (6th month). Brief interventions, 5A for those who are ready to change their behavior (Ask, Advise, Assess, Assist, Arrange); those who are not ready to change their behavior 5R (Relevance, Risks, Rewards, Roadblocks, Repetition) model will be used. At the end of brief interventions applied to overweight women with low health literacy for 20-30 minutes, a total of four times; weight change, waist circumference change, blood pressure change, blood glucose change, blood lipid change, diet, and exercise behaviors will be evaluated. The control group will not be intervened except for the first and last evaluations.

Eligibility Criteria:
Inclusion Criteria:

* Having heart disease, stroke, and chronic kidney failure diagnosed by a physician,
* Having diabetes that requires the use of insulin,
* Having hypothyroidism that prevents weight loss,
* Participating in a weight management program in the last 3 months,
* Being diagnosed with a disease that causes deterioration in cognitive processes such as Alzheimer's and dementia,
* Having a diagnosed physical or neurological problem that prevents him from doing physical activity,
* People who plan to become pregnant or become pregnant during the trial period (8 months after enrollment in the trial)

Exclusion Criteria:

* Between 12.09.2023 and 24.06.2024 two Primary healthcare organization applied,
* Volunteered to participate in the research,
* Women between the ages of 30-65,
* The level of health literacy is limited-restricted,
* 25≥ BMI \< 30,
* Those who can read and understand Turkish will be included in the study.
The Effect of Anesthetic Technique on VEGF-C and PGE2

The purpose of this study is to verify the effect of anesthetic technique on the change of postoperative serum vascular endothelial growth factor C and prostaglandin E2, and to explore the potential impact of the anesthetic technique on leiomyomas recurrence and growth after the surgery of abdominal myomectomy.

Uterine leiomyomas is the most common benign tumor of uterus, the most common tumor in women as well. Like many other forms of tumor, it requires an independent blood supply to enlarge. This process, angiogenesis, is mediated by vascular endothelial growth factor C (VEGF-C) and prostaglandin E2 (PGE2). Several studies have confirmed that VEGF-C has a high level in patients with uterine leiomyomas, which has also been demonstrated that it was related to occurrence and growth of uterine leiomyomas because it's capable of promoting angiogenesis, mitogenic, and vascular permeability-enhancing activities. Also, some researchers suggested that suppression of prostaglandin synthesis (including PGE2) via cyclooxygenase type-2 (COX-2) enzyme inhibition may reduce the incidence of some tumor. The aim of this study is to verify the effect of anesthetic technique on the change of postoperative serum VEGF-C and PGE2, and to explore the potential impact of the anesthetic technique on leiomyomas recurrence and growth after the surgery of abdominal myomectomy.

Eligibility Criteria:
Inclusion Criteria:

* The patients with leiomyomas requiring abdominal myomectomy, aged 18-65 year and American Society of Anesthesiologists (ASA) physical status I or II.

Exclusion Criteria:

* The patients who had a history of surgery within the preceding two weeks, a history of blood transfusion and a history of coronary artery disease, any contraindication to spinal anesthesia or opioid analgesia.
Detection of Efflux Pump Genes Mediating Ciprofloxacin Resistance in Staphylococcus Aureus Isolates in Sohag University Hospitals

Among multidrug-resistant bacteria, Methicillin-resistant Staphylococcus aureus (MRSA) isolates were recognized to be an important mortality factor in hospital infections and a major concern in health-care and community settings . The antibiotic-resistant of S. aureus is extended by various bacterial strategies, including limiting uptake of the drug, alteration of the drugtargets, production of druginactivating enzymes and the activation of efflux pumps that effectively remove antibiotics . Relying on the type of antibiotics, bacteria can apply one or more strategies. Specifically, localization of resistance genes in transferable genetic elements, such as plasmid and transposons , causing Horizontal transfer of resistance genes between bacterial strains . MRSA strains are resistant to nearly all beta-lactam antibiotics by producing an alternative penicillin-binding protein known as PBP2a . This protein is encoded by the mecA gene and has a low affinity to manybeta-lactam antibiotics. Furthermore, these strains often show resistance to a wide range of antibiotics . The use of fluoroquinolone for the effective infectious therapy is limited by presence of fluoroquinolone resistance . There are two mechanisms causing resistance to fluoroquinolone. The first one is attributed to mutations occurring in the quinolone-resistance determining region (QRDR) of topoisomerase IV encoded by grlA/grlB and DNA gyrase encoded by gyrA/gyrB; these mutations decrease the affinity ofthe drug. The other mechanism is mediated by efflux pumps which is less recognized . Recently, several efflux pumps have been identified for S. aureus including efflux pumps encoded by chromosome or plasmids. The efflux pumps norA, norB, norC, mdeA, sepA, mepA, sdrM and lmrS are encoded by chromosome while qacA/B, qacG, qacH, qacJ and smr are plasmid-encoded . Efflux pumps could be specialized for specific substrate or mobilized a wide varieties of different antibiotic classes . Despite, efflux pumps can potentially increase resistance to antibiotics in clinical isolates of S. aureus, few studies have been evaluated the individual and collective participation of the efflux system in resistant isolates . Therefore the aim of the study is to detect ciprofloxacin resistant strains of staphylococcus aureus isolates and to detect efflux pump genes ( norA , norB and norC ) mediating resistance in such strains.


Eligibility Criteria:
Inclusion Criteria:

* Infections caused by S.aureus like skin infections , chest infections , surgical site infections , and urinary tract Infections

Exclusion Criteria:

* Infections caused by any organisms other than S.aureus
The Effect of Occupational Therapy on Anxiety, Depression, and Psychological Well-Being Symptoms in the Elderly: A Single-Blind Randomized-Controlled Study

Participants were assigned to intervention and control groups according to the randomization list previously prepared by the researchers. All participants were first informed about the study and their informed consent was obtained. Participant Information Form, Geriatric Anxiety Scale, Psychological Well-Being Scale, and Geriatric Depression Scale were filled out by all participants.

The elderly in the intervention group were divided into 5 groups of 10 and a time was determined for the session in cooperation with the participants in each subgroup. A 60-minute therapy session was administered by the occupational expert. The applications were carried out in a total of 7 sessions as a daily session. The control group was not subjected to any application. Geriatric Anxiety Scale, Psychological Well-Being Scale, and Geriatric Depression Scale were refilled for the second time in all elderly on the 7th day after the application.

Participants were assigned to intervention and control groups according to the randomization list previously prepared by the researchers. All participants were first informed about the study and their informed consent was obtained. Participant Information Form, Geriatric Anxiety Scale, Psychological Well-Being Scale, and Geriatric Depression Scale were filled out by all participants.

The elderly in the intervention group were divided into 5 groups of 10 and a time was determined for the session in cooperation with the participants in each subgroup. A 60-minute therapy session was administered by the occupational expert. The applications were carried out in a total of 7 sessions as a daily session. The control group was not subjected to any application. Geriatric Anxiety Scale, Psychological Well-Being Scale, and Geriatric Depression Scale were refilled for the second time in all elderly on the 7th day after the application.

Eligibility Criteria:
Inclusion Criteria:

* The elderly, who agreed to participate in the study,
* were aged 60 and over, were cooperative,
* had no communication problems,
* and did not receive any training, course, or practice on coping with anxiety, tension, and stress were included in the sample.

Exclusion Criteria:
Determining Effectiveness of an mHealth Intervention to Provide Adolescent CBT

Washington University will evaluate the acceptability and effectiveness of a mobile health (mHealth) intervention to provide cognitive behavioral therapy for adolescents with depression.

In this pilot project, Washington University will start to evaluate CBot-A, a promising mHealth therapeutic intervention designed to deliver cognitive behavioral therapy (CBT) through an app on a phone or other mobile device. The evaluation will include a randomized trial among 40 adolescents diagnosed with depression and/or anxiety and will assess if CBot-A is usable by teens and likely to provide benefit, and acceptable to adolescents.

The primary outcome of depression and anxiety symptoms in adolescents will be assessed at 1 month and 3 months to check for any changes.

Eligibility Criteria:
Inclusion Criteria:

Adolescents 12-17 years of age and diagnosed with a major depressive disorder (MDD) and/or generalized anxiety disorder by their primary care provider within the past 3 months.

Exclusion Criteria:

Adolescents with the following conditions (identified by parental report) will be excluded:

* Participated in formal CBT within the past 12-months
* Diagnosed with severe depression
* Diagnosed with the following anxiety disorders - obsessive-compulsive disorders, post-traumatic stress disorder, panic disorder, or specific phobias
* A psychiatric hospitalization in the previous month
* With significant comorbidities such that the PCP would refer to a mental health professional for treatment, including those with a substance use disorder or a psychotic illness.
* Are not accompanied by a guardian to the diagnostic visit
* Without access to a mobile device (cell phone or tablet) for regular use
* Unable to read and write English
* Participants may also be excluded at the discretion of the PI.
Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery

The purpose of this study is to determine if the infusion of the local anesthetic ropivacaine (a numbing medicine) and the non-steroidal anti-inflammatory drug ketorolac (a pain killer similar to ibuprofen) through a catheter placed along the cesarean delivery incision, will reduce the pain experienced after cesarean section and need for narcotic pain medicine.


Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiology (ASA) class 1,2, and 3
* English speaking women at a gestational age \> 37 weeks
* scheduled for cesarean delivery under spinal or combined spinal epidural anesthesia

Exclusion Criteria:

* BMI \> 50 kg/m2
* history of intravenous drug or opioid abuse
* previous history of chronic pain syndrome
* history of opioid use in the past week
* allergy or contraindication to any of the study medications
* non-English speaking
Morphofunctional Imaging and Developmental Dyslexia

Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.


Eligibility Criteria:
Inclusion Criteria:

* Developmental dyslexia according to Critchley.
* Normal performance intelligence quotient (PIQ)
* Age: 18-35 years
* Sex: Male
* Right handed
* No hearing deficit.

Exclusion Criteria:

* No head injury
* No attention deficit hyperactivity disorder (ADHD)