cyrilzakka/clinical-trials huggingface dataset:
Laryngoscope Types and The Cervical Motion

To ensure minimal cervical motion during the intubation of trauma patients is important for the prevention of cervical spine injury (CSI) or further deterioration of existing CSI.

Intubation is required to secure the airway in patient during an anesthesia management or a mechanical ventilation at intensive care units. Laryngoscopes are the assisting tools for intubations. The most widely used laryngoscope type is one with a Macintosh blade. However, various types of laryngoscopes have been developed to be used for in case of difficult intubations, the intubation of the patients with head and neck trauma, or the intubation attempts carried out by inexperienced individuals. Truview EVO2® and Airtraq® are newly developed laryngoscopes, integrated with an optical view system.

The Truphatek TruView EVO2® (Truphatek International Ltd, Netanya, Israel) is a recently introduced, easy viewing type of laryngoscope, modified from the blades of Macintosh type laryngoscopes, having an angle of 46° at the end of blade and including a camera system that magnifies the image.

The Airtraq® laryngoscope (ATQ; King Medical Systems, Newark, DE) is also a newly developed type of laryngoscope, including optical imaging system. There is a channel on the device for the placement of the endotracheal tube. Endotracheal tube is inserted into the channel before the laryngoscopy. It has been reported that Airtraq is a novel single use laryngoscope which provides glottis display without any deviation in the normal position of the oral, pharyngeal or the tracheal axes.

In the literature, there are many studies comparing the effects of these newly developed laryngoscopes on cervical motions in different scenarios with cadavers and normal patients. However, in these studies, individual vertebral motion was reported during the placement of the tube, while the angulation of the head and neck and the difficulty of the intubations were not clear.

In this study our first hypothesis was cervical motion during endotracheal intubation in Truview EVO2® and Airtraq® types of laryngoscopes is lesser than Macintosh. The second one was the endotracheal intubation time is similar to the Macintosh that is used more often.


Eligibility Criteria:
Inclusion Criteria:

The patients who will undergo general anesthesia for abdominal surgery, American Society of Anesthesiologists physical status I to III, The patients who were aged between 20 and 75

Exclusion Criteria:

Our exclusion criteria were to have a history of emergency intubation or a difficult intubation, to have a body mass index higher than 35 or a rheumatologic disease that cause limitation of cervical motion, to have a previous history of cervical operation or tumor, trauma or infection on upper airway, and to have no tooth.
Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Clinical Safety and Effectiveness in Patients With Alzheimer's Disease

To investigate the clinical safety and effectiveness of donepezil hydrochloride administration in patients with mild or moderate Alzheimer's Disease


Eligibility Criteria:
Inclusion criteria;

Patients diagnosed as Alzheimer's Disease by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).

Patients diagnosed as mild or moderate Alzheimer's Disease, applicable to Functional Assessment Staging (FAST) score 4 or 5.

Exclusion criteria;

Patients who used Aricept within 3 months prior to dosing.

Patients registered this survey before.

Patients with a history of hypersensitivity to any ingredients of Aricept or piperidine derivatives.
Engaging Pacific Islander Perspectives on Mental Illness and Mental Health Services

This study will enroll 100 Samoan and 100 Marshallese adults to discuss mental health, mental disorders, and approaches for engaging Pacific Islander adults with mental illness into mental health services.

Despite enduring high mental health burden, Pacific Islanders have received minimal research or clinical attention in the US. Due to our poor understanding of the issues surrounding Pacific Islander mental health, engaging Pacific Islanders in mental health services has been very difficult.

This study draws from the Cultural Determinants of Help-Seeking Model to address this research and clinical gap by conducting focus groups and citizens' panels to obtain public input from 50 Samoans in LAC and 50 Marshallese in Arkansas on their unique mental health perspectives, needs, barriers and facilitators to services, and strategies to overcome these barriers. The citizens' panels will bring together lay public members, present multiple viewpoints about various mental health issues, and have members deliberate and reach a collective decision on these issues. All group materials will be translated into English, Samoan, and Marshallese, and interpreters will be present during the sessions. The groups will be audio-recorded, transcribed verbatim, and analyzed by the Research Team for themes. Numerical data will also be collected about levels of public awareness about mental illness, mental health stigma, acculturation, and underutilization of mental health services from 100 Samoan and 100 Marshallese community members to better understand these possible service barriers.

Analyzed data will be used to develop a set of intervention components that are likely to increase service engagement among both Samoans and Marshallese. These components will provide the foundation for a universal service engagement intervention for Pacific Islanders that will be developed and tested in future research.

Eligibility Criteria:
Inclusion Criteria:

* Samoan or Marshallese heritage; living in Los Angeles County or Northwest Arkansas; age 18 years or older; English, Samoan, or Marshallese oral and reading fluency

Exclusion Criteria:

* Not of Samoan or Marshallese heritage; living outside the catchment areas; younger than 18 years; not fluent in English, Samoan, or Marshallese
Brief Assessment of Impaired Cognition

The aim is to develop and validate a new brief and accurate case-finding instrument for dementia and cognitive impairment - BASIC

The case-finding instrument consists of four components: a. patient-directed questions, b. supermarket fluency, c. category-cued Memory Test, d. informant-directed questions.

The data collection was carried out at five outpatient memory clinics in Denmark

Eligibility Criteria:
Inclusion Criteria:

* fluent in Danish

Exclusion Criteria:

* impaired eyesight or hearing
Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study

Introduction. Comprehensive data on infective endocarditis in developing countries are scarce.

Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis in low-income countries.

Methods : Prospective, Observational, Multicentre study. Inclusion criteria: patients aged over 1 year fulfilling the modified Duke criteria for infective endocarditis.

Exclusion criteria: patient included during a previous infective endocarditis episode.

Outcomes measures: Mortality at 6 months follow-up; mortality at 1 month follow-up; access to antibiotic treatment (modalities and duration), hospital length of stay and reason for discharge, and cardiac surgery when indicated.

Duration: One year (June 2014- June 2015)


Eligibility Criteria:
Inclusion Criteria:

* Patients aged over 1 year diagnosed with infective endocarditis according to the modified Duke criteria

Exclusion Criteria:

* Already included for a previous episode of infective endocarditis (i.e., relapse or reinfection)
Myocardial Hybrid Revascularization Versus Coronary artERy Bypass GraftING for Complex Triple-vessel Disease

This is a pilot randomized study that aim to assess the safety and feasibility of a hybrid myocardial revascularization strategy (coronary artery by-pass graft and percutaneous intervention) in comparison with conventional surgical coronary bypass grafting.


Eligibility Criteria:
Inclusion Criteria:

* Triple-vessel disease with proximal or mid LAD disease with angiographic diameter stenosis \> 70% by visual analysis in all three territories, requiring myocardial revascularization OR triple-vessel disease with proximal or mid LAD disease with angiographic diameter stenosis 50-70% by visual analysis in any territory but with invasive or non-invasive evidence of flow-limiting stenosis in all three territories, requiring myocardial revascularization
* Total SYNTAX score \> 22
* LCx and RCA territories estimated to be equivalently revascularized by either PCI or CABG, with at least one major non-LAD vessel to be treated
* Clinical and anatomic eligibility for both PCI and CABG as agreed to by both interventional and surgical consensus

  * Interventionalist determines PCI appropriateness and eligibility
  * Surgeon determines surgical appropriateness and eligibility
* Silent ischemia, stable angina, unstable angina or recent MI

  * If recent MI, cardiac biomarkers must have returned to normal prior to randomization
* Ability to sign informed consent and comply with all study procedures

Exclusion Criteria:

* Prior PCI or CABG at any time prior to randomization
* Need for any concomitant cardiac surgery other than CABG (e.g. valve surgery, aortic repair, etc.), or intent that if the patient randomizes to surgery, any cardiac surgical procedure other than isolated CABG will be performed
* Patients unable to tolerate, obtain or comply with dual antiplatelet therapy for at least one year
* Patients requiring additional surgery (cardiac or non cardiac) within one year
* The presence of any clinical or anatomical condition(s) which leads the participating interventional cardiologist to believe that clinical equipoise is not present (i.e. the patient should not be treated by PCI, but rather should be managed with CABG or medical therapy - reasons will be documented)
* The presence of any clinical or anatomical condition(s) which leads the participating cardiac surgeon to believe that clinical equipoise is not present (i.e. the patient should not be treated by CABG, but rather should be managed with PCI. or medical therapy - reasons will be documented)
* Non cardiac co-morbidities with life expectancy less than 1 year
* Other investigational drug or device studies that have not reached their primary endpoint.
Emotional Impact of the Way Conducting Cancer Patients to the Surgical Center

Cancer is an extremely aggressive disease, anxiety and depression are consequences some patients may develop from diagnosis continuing during treatment. A measures control of the cancer is surgery for removal tumor. The surgical procedure is often a difficult experience for patients and their relatives, and patients in the preoperative period are often psychological symptoms of anxiety and depression. A previous study with the objective analyzing patient's emotional repercussion according the type of transport to the surgical center reached the following result: patients who go to the surgical center feel more relaxed in the preoperative period.

The primary objective is to analyze emotional repercussion of patient diagnosed with cancer classified in Eastern Cooperative Oncology Group (ECOG) Performance Status 0 and 1 according type transport to the surgical center.

A randomized clinical trial, prospective collection to be performed at the Barretos Cancer Hospital, will be include 176 patients, 88 patients being allocated to transport to operating room by stretcher on wheels (group 1) and 88 patients being allocated to transport to operating room by ambulation (group 2). Patients with indication elective surgery that meet the inclusion criteria will be included, and randomized for one of the groups, and may be referred by stretcher on wheels to the surgical center (group 1) or referred to the surgical center by ambulation (group 2). The Hospital Anxiety and Depression Scale (HAD) and the survey developed for the present study Sati-Cir, Evaluation Questionnaire of Satisfaction with Healthcare in Surgery, will be the instruments used in data collection. Participants will respond both after the course to the surgical center.

Eligibility Criteria:
Inclusion Criteria:

* diagnosed cancer
* Age ≥18 years, ≤ 70 years
* Both sexes
* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score 0 or 1
* Patients classified as Zero or Low Risk by the fall risk assessment scale
* Indication elective surgery

Exclusion Criteria:

* Patients who present moments before surgery has an adverse event that could jeopardize the ambulation to the surgical center.
* Patients who are physically disabled and require assistance walking.
* Patients has indication bed in the Intensive Care Unit (UTI)
* Patients has previously diagnosed psychiatric disorders (severe depression, anxiety disorder, panic, among others).
* Patients doens't have an accompanying person on the day of surgery.
* Patients taking anxiolytic and antidepressant medications.
The Factors Affecting Intentions of Medical Staff to Use Personal Health Record in Northern Hospitals of Taiwan

Application of health information technology be able to solve a lot of problems of medical management, and effective actions to achieve the purpose of medical care. The "Personal Health Record" (PHR), so that patients can have, access and update their health records and share health information to a new healthcare provider can avoid the duplication of a clinic procedures, reduce medical costs and time, and can make an appointment online, tracking vaccinations, check drug allergy, master with health-related information such as exercise, diet condition, and have no time constraints to the hospital clinic. In the future, PHR is expected to reduce medical errors, reduce costs, effective use of medical resources. Purpose of this study is to understand the impact to the staff's attitude and intention when they use the PHR, and to explore the medical records of personal health awareness and intention to use the relevant factors, the research result will be a reference to government authority or medical institutions in order to promote personal health record system in Taiwan.

In this study, there will include the medical staff of three hospitals in Taipei, the Technology Acceptance Model (TAM model) based structured questionnaire will be used, questionnaire had tested by validity and reliability. The electronic questionnaires will be used, and apply the software SPSS and Amos17.0 descriptive and inferential statistical analysis.


Eligibility Criteria:
Inclusion Criteria:

* Health care provider
* Volunteer Subject
* Be able to understand the content of questionnaire

Exclusion Criteria:

- None
Thora-3DI™ for Evaluation of Severity of Chronic Obstructive Pulmonary Disease (COPD)

To demonstrate differences in tidal breathing patterns measured by SLP(Structured Light Plethysmography) between healthy subjects and COPD (chronic obstructive pulmonary disease). The correlation between SLP parameters and standard lung function parameters measured by body box and spirometry will also be assessed. Trends in SLP breathing patterns between the different GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages of COPD, and between those and healthy subjects, will be investigated to assess whether SLP can detect differences between groups.

Structured light plethysmography (SLP) is a novel, non-contact method for assessing quiet 'tidal' breathing. A number of studies have reported the effects of conditions such as chronic obstructive pulmonary disease (COPD) on tidal breathing patterns, and a previous study has shown that SLP is able to detect differences in ten tidal breathing patterns between healthy subjects and patients with COPD. In this present study, the investigators will aim to confirm the previous findings and also to examine the relationship between SLP tidal breathing parameters and traditional measurements of lung function measured by spirometry and body box plethysmograph. The correlation between SLP parameters with lung Function parameters measured by spirometry and body box plethysmography: forced expiratory volume in one second (FEV1); Forced vital capacity (FVC), FEV1/FVC (forced expiratory volume in one second/forced vital capacity); total lung capacity (TLC) and residual volume (RV). Trends in tidal breathing patterns between varying severities of COPD (based on the (Global initiative for lung disease (GOLD) grading system.

Eligibility Criteria:
Inclusion Criteria:

* Age range 18-80 years,
* BMI range 18-40 kg/m2
* Patients diagnosed, or suspected, with COPD or normal subjects with no previous or current diagnosis of respiratory disease

Exclusion Criteria:

* Patient unable to sit in an upright position for required period of time
* Patients with significant co morbidities (assessed by the clinician at screening only):
* Significant unilateral lung disease e.g. pneumonectomy
* Chest wall or spinal deformity e.g. scoliosis
* Obstructive sleep apnea (OSA), Apnoea hypopnoea index \> 30 (if known)
* BMI\>40
* Inability to consent/comply with trial protocol
* Presence of an acute disease process that might interfere with test performance, e.g. Nausea, vomiting, persistent coughing)
The Correlation Between the n-6:n-3 Ratio and Inflammatory Markers in Small for Gestational Age (SGA) Infants Compared With Appropriate for Gestational Age (AGA) Infants

Numerous studies have recommended the use of n-3 PUFA supplementation during human pregnancy and lactation for the prevention of preterm birth, beneficial effects on fetal development, visual and cognitive development and other functional outcomes of the infants.

The aim of the present study is to assess the correlation between ratio of n-3:n-6 fatty acid and inflammation markers in SGA infants compared with appropriate for gestational age (AGA) infants. The investigators hypothesize that in SGA infants n-3 and n-6 fatty acid concentrations in cord blood will differ from those observed in AGA and might correlate with the level of circulating mediators.


Eligibility Criteria:
Inclusion Criteria:

* Mothers of SGA infants ( above 35 week of gestation)
* Mothers of term and near-term AGA infants

Exclusion Criteria:

* Maternal chronic diseases, smoking, diabetes, alcohol use, pregnancy-associated hypertension and pre-eclampsia
* Neonatal depression
* Congenital malformations
* Intrauterine infections
* Chromosomal aberrations
* Mothers interested in cord blood banking
Correlation Between Preoperative Knee Extension Lag and Functional Outcome After Total Knee Arthroplasty

To explore the relationship between different knee extension hysteresis angles and functional outcome of knee joint after total knee replacement

1. Collect perioperative baseline data

   Subjects were recruited and perioperative baseline data were collected: ① Demographic information, including age, sex, height, weight, affected knee, etc. ②Body structure and function: joint motion, knee extension hysteresis angle, pain NRS, WOMAC assessment, and ultrasonic knee extension mechanism were measured before and 3 days after surgery.
2. Postoperative follow-up

   The patients were followed up for 3 months, and 6 weeks /3 months after surgery was selected as the follow-up node. The follow-up included postoperative range of motion, knee extension hysteresis Angle, pain NRS, WOMAC assessment, ultrasonic measuring knee extension mechanism, TUG Test (Timed Up-to-go Test), isometric muscle force test, balance postural graph, gait analysis, etc.
3. Data analysis

   1. Multi-factor regression analysis was performed to determine the main outcome indicators of WOMAC evaluation at 3-month follow-up, including range of motion, Angle of knee extension hysteria, pain NRS, ultrasonic knee extension device, TUG Test (Timed Up-to-go Test), isoktatic muscle force test, balance postural graph and secondary outcome indicators of gait analysis. The perioperative knee extension hysteresis Angle was used as the independent variable to construct the postoperative regression model of knee function.
   2. According to the Angle of knee extension hysteresis in perioperative period, patients were divided into 4 groups: ≤5°, 5-10°11-15°, ≥15°, The results of range of motion, knee extension hysteresis Angle, pain NRS, WOMAC score, ultrasonic knee extension device, TUG Test (Timed Up to go Test), iso-tachykinesis test, balance postural mapping and gait analysis were compared among all groups 3 months after surgery.
4. Study outcome

Follow-up was completed; The patient underwent revision surgery for knee osteoarthritis. The patient dropped out of the trial for personal reasons; Other unforeseen circumstances prevented the patient from continuing the trial.

Eligibility Criteria:
Inclusion Criteria:

* (1) Patients who meet the diagnostic criteria of knee osteoarthritis (age \>45 years old); (2) Patients admitted to the Department of Orthopedics of the Third Hospital of Beijing Medical University and preparing to receive TKA surgery; (3) The patient has good cognitive function and good compliance, and can cooperate with various examinations; (4) Voluntarily participate in the study and sign the informed consent;

Exclusion Criteria:

* (1) Patients with lower extremity fracture and severe lumbar spinal stenosis that affect postoperative functional recovery; (2) Patients with severe cerebrovascular disease who cannot cooperate with postoperative rehabilitation exercise; (3) The time interval of double knee replacement was less than 3 months.