cyrilzakka/clinical-trials huggingface dataset:
Clinical Validation Study for Noninvasive Cardiopulmonary Management Device

The ADI At-Home CPM (Cardiopulmonary Management) System is a non-invasive device that measures and trends a variety of biological parameters.

This study will be conducted as a prospective non-randomized study with two study arms/cohorts - one of healthy adult patients, one of pathologic patients who fit into the intended use population of the CPM System.


Eligibility Criteria:
Inclusion Criteria:

I. Healthy Cohort:

1. Adults over the age of 18 and who are willing and able to give informed consent.
2. Willing to participate in all activities related to this study, including trimming chest hair and wearing a reference device and the CPM wearable device.
3. Volunteers of any race, any gender
4. Range of physiques
5. Healthy

II. Pathologic Cohort

1. Adults over the age of 21 and who are willing and able to give informed consent
2. Willing to participate in all activities related to this study, including wearing a capnography device, thoracic impedance reference device, and the CPM wearable device.
3. Those who:

   1. Are taking diuretic medications
   2. Are living with heart failure
   3. Have chronic obstructive pulmonary disorder (COPD)
   4. Are recovering from a coronary-artery disease-related event.
4. Volunteers of any race, any gender-Range of physiques.

Exclusion Criteria:

I. Healthy Cohort

1. Injury or skin disturbance in the area of the test device
2. Pregnant
3. Currently smokes cigarettes
4. Has known respiratory conditions such as:

   1. Flu
   2. Pneumonia/bronchitis
   3. Shortness of breath/respiratory distress
   4. Respiratory or lung surgery
   5. Emphysema, COPD, lung disease
5. Has self-reported heart or cardiovascular conditions such as chest pain, AFib, CHF, cardiomyopathy, or other conditions that could interfere with cardiopulmonary function
6. Has other self-reported health conditions that could interfere with the breathing patterns and exercises detailed in the protocol (including wearing a capnography mask)

II. Pathologic Cohort:

1. Under the age of 21
2. Cognitive or physical impairment sufficient enough to interfere with informed consent or successful completion of the protocol.
3. Injury or skin disturbance in the area of the test device.
4. Pregnant.
5. Have life-threatening arrhythmias which require hospital admission and constant monitoring.
6. Has other self-reported health conditions that could interfere with wearing a capnography mask.
Determining Shapes and Dimensions of Dental Arches for the Use in Lingual Technique.

This study aims to determine the shape and dimension of dental arches from a lingual perspective, and determine shape and size used for lingual Orthodontics.

The study sample comprised 70 Caucasian Brazilian individuals with normal occlusion and at least four of Andrew's six keys. Maxillary and mandibular dental casts were digitized (3D) and the images were analyzed by Delcam Power SHAPET 2010 software. Landmarks on the lingual surface of teeth were selected to determine the shape and size of dental arches.

Eligibility Criteria:
Inclusion Criteria:criterion was that individuals should be at least 15 years of age all permanent teeth in occlusion -

Exclusion Criteria:with no odontogenic abnormalities

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Knowledge Attitudes Beliefs and Practices Regarding HIV Among Teenagers in French Guiana

French Guiana is the French territory where the prevalence of HIV is highest. in order to determine the knowledge attitudes, beliefs, and practices among the target group of teenagers attending the public school system a survey was conducted in 2011. schools and classrooms were randomly selected, and a structured questionnaire was administered. Descriptive statistics were obtained and multivariate logistic regression was used to determine predictors of main outcomes such as age at first sex.

the results will be used to guide prevention of HIV and sexually transmitted infections though the school system.


Eligibility Criteria:
Inclusion Criteria:

* attending the public school system of french guiana

Exclusion Criteria:

* refusal to participate
Esophageal Absorption in EoE

To determine how the esophagus in active and inactive stages of eosinophilic esophagitis tranmit fluids.


Eligibility Criteria:
Inclusion Criteria:

* Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study
* endoscopy with esophageal and duodenal biopsies within two weeks of performance of this study
* Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study, and are now in histologic remission( \<15phf) by the use of steroids or the six food elimination diet.
* Volunteers will be selected for not having any history of esophageal symptoms

Exclusion Criteria:

* Vulnerable populations, such as those with diminished mental acuity, will be excluded.
* Patients taking Nsaids within 48 hours of the d-xylose testing
* artificial sweeteners within 48 hours of the d-xylose testing
* History of IBD
* Currently smoking or history of smoking
* History of Celiac disease
* Bacterial overgrowth,
* motility disorders
* other diffuse small bowel diseases.
The Effects of Kinesiotaping on Balance in Children With Down Syndrome.

This study aimed to explore the effects of Kinesio tape applied to plantar soles on balance in children with Down Syndrome (DS). Two groups including children with DS and a group with their typically developing peers evaluated. Half of the children with DS took Kinesio tape application to the plantar soles and the other half took sham taping application. All children evaluated with dynamic and static balance measurements and DS children evaluated immediately after taping and 45 minutes after taping again with the same measurements.

Balance is one of the most problematic issues in children with DS. Mechanoreceptors of plantar region of the foot helps to regulate human erect posture and balance. Studies shows that inputs from foot sole give a positive effect in improving balance both in healthy and neurologically demaged subjects. Kinesio tape is a supportive method in physiotherapy with it's proprioceptive input giving effects. It is aimed to show the acute effects of Kinesio tape on balance parameters in children with DS.

Eligibility Criteria:
The inclusion criteria for healthy children:

* Not having any orthopedic or neurological disorder
* To understand and do the commands given
* Being willing to participate in the study

The inclusion criteria for children with DS:

* To have diagnosis of DS
* Not having any orthopedic or neurological disorder in addition the DS
* To understand and do the commands given
* Being willing to participate in the study.

Exclusion criteria for all children:

* Auditory and visual problems (not using glasses)
* Operated in last 6 months prior to he study
Subacromial Ultrasound-guided or Systemic Steroid Injection for Rotator Cuff Disease, a Randomized Double Blinded Study

Corticosteroid injections is a popular treatment option in shoulder disease. The evidence of effectiveness of corticosteroid injections is however contradicting. The importance of the accuracy of the steroid placement have been discussed and recently there are a few studies indicating better treatment effect if the injections are guided towards specific anatomical structures by real time ultrasound imaging. None of these studies have been double blinded. The aim of this study is to investigate the importance of placement of steroid injection in patients with rotator cuff disease by comparing systemic and ultrasound-guided injection in the subacromial bursa using a double blinded design.


Eligibility Criteria:
Inclusion Criteria:

* above 18 years
* shoulder pain for more than 3 months
* pain at abduction of the affected shoulder
* less than 50 % reduced passive glenohumeral range of motion in no more than one direction of either abduction, external or internal rotation
* 2 of 3 positive isometric test of external rotation, internal rotation and abduction
* positive Hawkins-Kennedy impingement test

Exclusion Criteria:

* SPADI score below 30 points
* symptomatic acromioclavicular arthritis
* clinical and radiological findings indicating glenohumeral joint pathology
* referred pain from neck or internal organs
* clinical signs of a cervical syndrome
* generalized muscular pain syndrome with bilateral muscular pain in the neck and shoulders
* history of inflammatory arthritis
* diabetes mellitus type 1
* contraindications to local steroid or lidocaine hydrochloride injections
* corticosteroid injections last month before inclusion
* unable to respond to questionnaires
Comparative Analysis of Isolated Venous, Isolated Arterial, and Standard Access for Transcatheter Closure of Patent Ductus Arteriosus (PDA)

We enrolled all patients with a hemodynamically significant PDA demonstrated by patient clinical condition, and by PDA size \& left chamber dilatation on echocardiography attending at Cardiology Department to we compare the use of a single venous access and a single arterial access with the standard approach requiring both venous and arterial access for transcatheter PDA closure regarding the outcome \& complications.


Eligibility Criteria:
Inclusion Criteria:

* any patient with hemodynamically significant PDA

Exclusion Criteria:

* patient with pulmonary hypertension and Eisenmenger syndrome
Women's Positive Birth Perception Awareness and Birth Experience

it was aimed to determine the effect of empathic communication-based education on positive birth perception awareness.

Since the existence of humanity, women have not been left alone during pregnancy, childbirth and postpartum period in all societies, but have been supported by their environment. In providing this support, midwives have important responsibilities as the primary responsible health professional . Quality midwifery care given at birth is very important for women to have a positive birth experience The biggest expectations of mothers from midwives in the birth and postpartum period are; it is approaching with empathetic communication such as smiling, therapeutic touch, listening, speaking in a language that the pregnant can understand, making oneself feel good, encouraging, informing, paying attention to privacy. Mothers whose expectations are met in labor; It can have positive obstetric outcomes such as shortening the delivery time, reduction in analgesia and medical intervention applications, positive birth experience, initiation of breastfeeding in the early period, mother-infant bonding and transition to the role of motherhood .

İt will contribute positively to the health indicators of the country and reduce the cost, a scale and guide have been prepared within the scope of this thesis, with the foresight that pregnant women and health workers need training materials, and training with interactive and mobile communication tools in this direction. has been planned.It is expected that the training to be given in line with the developed guideline, and the empathic communication-based training given in the third trimester of pregnancy will help to increase the awareness of women's positive perception of birth.

With this study, it was aimed to determine the effect of empathic communication-based education on positive birth perception awareness.

Eligibility Criteria:
Inclusion Criteria:

* 18 years and older pregnancy

  * Speaks and understands Turkish
  * Able to read and write,
  * Having a single fetus,
  * Not having a risky pregnancy,
  * 32-36. in gestational week,
  * Pregnant women who do not have any disability diagnosed for normal delivery

Exclusion Criteria:

* Risky pregnant women
* Pregnant women with communication difficulties
* Pregnant women with mental deficiency
Decision-making Regarding Prophylactic Mastectomy and Oophorectomy in Women Seeking Genetic Counseling and Testing for BRCA1/2 Mutations

The purpose of this study is to learn more about women's decision to undergo prophylactic surgery. This is removal of healthy organs in order to reduce risk of cancer. This study will help us to understand what makes women decide whether or not to have this kind of surgery.

For women with a strong family history of breast/ovarian cancer, few options exist for primary prevention of these cancers other than prophylactic surgery, or surgical removal of noncancerous organs in order to prevent occurrence of the disease. The primary aim of the study is to describe the stages of intention to undergo prophylactic mastectomy and/or oophorectomy among women seeking genetic testing for inherited BRCA1 and BRCA2 mutations, and to identify factors that influence stages of intention regarding prophylactic surgery. To achieve these aims, 626 women undergoing genetic counseling and testing for inherited breast ovarian cancer risk will be assessed before their first genetic counseling session and three times (1 week, 6 months and 12 months) in the year following notification of their genetic test results.

Eligibility Criteria:
Inclusion Criteria:

* Female gender
* age 25 and above
* a personal or family history of breast and/or ovarian cancer showing clinical features associated with increased risk of carrying a BRCA1/2 mutation (e.g., breast and ovarian cancer on the same side of the family, early age of onset, multiple primaries in the same individual) or having a first-degree relative with a known BRCA1 or BRCA2 mutation.

Exclusion Criteria:

* Male gender
* age less than 25 years
* unable to provide meaningful informed consent due to physical, cognitive or psychiatric disability
* non-English speaking
Pharmacogenomic Study (Adjuvant Chemotherapy)

To assess the role of germline polymorphisms in xenobiotic metabolism genes in toxicity profile.

To assess the role of germline polymorphisms in genes associated with DNA repair, p53 tumor suppressor gene and angiogenesis pathway in predicting recurrence and survival in gastric cancer patients treated with adjuvant chemotherapy.


Eligibility Criteria:
Inclusion Criteria:

* gastric cancer patients treated with adjuvant chemotherapy

Exclusion Criteria:
CYclosporine A in Shockable Out-of-hospital Cardiac Arrest ResUScitation

Cardiac arrest (CA) is a public health problem in industrialized countries. The prognosis of these patients remains poor with significant mortality and severe neurological sequelae in survivors.

The objective of the present study is to determine whether cyclosporine can improve patient clinical outcome after shockable CA. 520 patients with CA will be entered into a multicentre, randomized, placebo-controlled study. They will receive one single injection of cyclosporine (or placebo) prior to resuscitation. The incidence of the combined endpoint (mortality, irreversible brain damage informations such as bilateral abolition of N20 wave or absent motor response or extension to the nociceptive stimulation...) will be assessed 7 days after CA.


Eligibility Criteria:
Inclusion Criteria:

* Witnessed out-of-hospital cardiac arrest
* Shockable cardiac rhythm at first medical contact (ventricular fibrillation, ventricular tachycardia)

Exclusion Criteria:

* Evidence of trauma
* Evidence of pregnancy
* Duration of no flow more than 30 minutes
* Rapidly fatal underlying disease
* Allergy to cyclosporin A
Adherence & Health Outcome Differences Amongst HIV Infected Patients Prescribed HAART

This study is designed to see how HIV infected patients perform when taking a single fixed dose HIV medication compared to a regimen with multiple tablets. The study is also going to be looking at the differences in complications between the two groups.

This is a phase IV retrospective chart review of HIV infected patients in a private Infectious disease practice in West Palm Beach, FL. This chart review will assign patients into one of two groups based on their antiretroviral regimen: single tablet regimen (STR) versus multi tablet regimen (MTR). Up to 650 patient charts will be reviewed but only about 500 patients are needed for statistical analysis.

The primary objective is to look at the proportion of patients with an adherence rate greater than or equal to 95% in subjects prescribed STR versus a MTR.

Secondary Objectives:

* Differences in emergency room visits, hospitalization and readmission in patients taking a STR vs. a MTR
* Proportion of patients with HIV viral load less than 50copies/microliter
* Incidence of new onset or worsening hyperlipidemia in patients taking a STR versus a MTR
* Incidence of acute renal insufficiency
* Compare the absolute CD4 number increase between a STR and a MTR
* Compare monthly copay amounts in patients taking a STR versus a MTR
* Identify the incidence of opportunistic infections in patients taking a STR versus a MTR

Eligibility Criteria:
Inclusion Criteria:

* Male or Female (gender at birth), age 18 years or older
* Documented HIV-1 infection by western blot or HIV viral load
* Prescribed antiretroviral therapy, either STR (single tablet regime) or MTR (multi tablet regimen) for at least 6 months
* Patients should have a minimum of 3 office visits

Exclusion Criteria:

* Patients who were evaluated in the hospital but never came to the clinic
Effect of Back School-based Intervention on Non-specific Neck Pain in Adults.

The study consists of a theoretical and practical intervention based on the Back School. This intervention will be carried out over 8 weeks with a frequency of two sessions per week, for a total of 16 sessions of 45 minutes duration. Of all the sessions, 14 had a practical focus (strength and stretching exercises) and the other two had a theoretical focus (self-management techniques and pain neuroscience education). In addition, they had an initial session and a session at the end of the of the intervention in which measurements of the different variables were taken (The Visual Analogue Scale; Neck Disability Index; Tampa Scale Of kinesiophobia).These variables will be measured on two occasions, at the beginning of the study and at the end of the intervention, an average of 2 months.

The clinical practice guidelines highlight the importance of neck pain prevention through exercise an education. There are previous studies of the effects of theoretical and practical programmes based on back school on the lumbar region but not on the cervical region. Therefore, the aim of this study is to investigate the effects of a BS-based intervention on neck pain and functionality as well as kinesiophobia and quality of life in adults. The hypothesis previously hypothesised that this BS-based intervention would have positive effects on pain, functionality, kinesiophobia and quality of life.


Eligibility Criteria:
Inclusion Criteria:

* 18-65 years of age.
* With non-specific neck pain for at least three months, with pain intensity (30-70 on a VAS).

Exclusion Criteria:

* Any previous neck or shoulder surgery, fibromyalgia, cervical radiculopathy/myelopathy, history of the whiplash injury, cognitive disorder.
* Missing more than two Back School sessions.
* Not being able to attend the measurement sessions.
The Effects of Calorie Restriction With or Without Metformin on Weight and Insulin Resistance

This is a study to:

* Determine the difference between strong hypo-energetic "standard diet advice" and modest hypo-energetic "personal diet advice"; and
* Determine the influence of insulin-insensitivity on obesity and weight reduction by treating patients with metformin or placebo.

The aim of the present study was to determine what the difference is of a strong hypo-energetic "standard diet advice" and a modest hypo-energetic "personal diet advice" which was determined by the energy needs of a person as calculated with a combination of basal metabolic rate (BMR) and physical activity level (PAL) on weight loss and insulin sensitivity.

Secondly, this study wanted to determine what the influence is of insulin-insensitivity on obesity and weight reduction by treating the patients with metformin or placebo. The subjects were therefore randomised into two double blinded groups receiving either metformin (2 x 850 mg per day) or placebo in combination with a moderate energy restriction and a exercise regimen of 30 minutes per day for 1 year.

Treatment effects of both diets and the effect of metformin on weight reduction and insulin sensitivity were determined after a treatment period of 20 and 52 weeks.

Insulin sensitivity was quantified using the homeostasis model assessment (HOMA) and the OGTT. Body composition was determined with the bioelectrical impedance method.

Blood was also drawn for hormonal and biochemical analyses after 20 and 52 weeks of treatment. Furthermore, the patients had to fill out a 3-day food diary at baseline, after 20 weeks and after 52 weeks.

Eligibility Criteria:
Inclusion Criteria:

* 20-55 years of age
* Body mass index (BMI) equal to or greater than 30 kg/m²
* Insulin resistance as determined by oral glucose tolerance test (OGTT) and HOMA

Exclusion Criteria:

* Diabetes mellitus, kidney insufficiency, or hepatic insufficiency
* Hypogonadism with other etiology than overweight
* Pregnancy
* BMI equal to or greater than 40 kg/m²
Safety, Tolerability, PK and Efficacy of AZD1152 in Patients With Relapsed Acute Myeloid Leukemia

The purpose of this study is to assess safety and tolerability of multiple ascending doses of AZD1152 and to assess effect of AZD1152 on the rate of complete remission in patients with relapsed acute myeloid leukaemia.


Eligibility Criteria:
Inclusion Criteria:

* Relapsed or refractory AML for which no standard therapies are anticipated to result in durable remission
* Newly diagnosed AML who are not considered suitable for other treatments.

Exclusion Criteria:

* Previous myeloablative therapy allogeneic bone marrow or stem cell transplantation, radiotherapy or chemotherapy within 4 weeks of first dose.
* Participation in any other trial with an investigational product within the previous 30 days
* Other active malignancy.
Extension Study to Assess Batoclimab in Participants With Thyroid Eye Disease

This is a 2-cohort (observational and treatment cohort) extension study for participants completing feeder studies (IMVT-1401-3201 or IMVT-1401-3202). The observational cohort will assess the durability of proptosis response of feeder studies off treatment. The treatment cohort will evaluate the efficacy of batoclimab as assessed by proptosis responder rate.


Eligibility Criteria:
Inclusion criteria:

For all participants:

1. Have completed the Week 24 visit of the feeder study.

For participants assigned to the Open-label Treatment Cohort:

1. Do not require immediate surgical intervention and is not planning corrective surgery/irradiation or medical therapy for TED during the course of the study.
2. Did not permanently discontinue batoclimab

Additional inclusion criteria are defined in the protocol.

Exclusion criteria:

For all participants:

1. In the Investigator's judgement, the benefits of entry in the study do not outweigh the risk.