cyrilzakka/clinical-trials huggingface dataset:
Effects of Stationary Cycling and Progressive Functional Training in Cerebral Palsy Children

Cerebral palsy is not a progressive disease but movement problem and musculoskeletal disorders in cerebral palsy change with time. Children with CP usually with the lower limb involvement presents with muscle weakness, limited muscular control which results in muscular insufficiency, coordination and balance impairment. These impairments effect the normal activities of child in daily living. There are many children who have good cognition but poor lower limb coordination which is leading cause of disability in them and multiple factors are responsible for them like lake of awareness in parents, no time, expensive therapy program and inappropriate techniques.

The study will be randomized clinical trial and will be conducted in Bahawalpur. The study will be completed in time duration of 6 months after approval of synopsis. Non probability convenience sampling technique will be used and 22 children will be recruited in the study meeting the inclusion criteria. The participants will be divided into two groups through randomization using lottery method. Group A will perform 10-15 minutes of stationary cycle training, 3 times a week for 6 weeks. While group B will be given progressive functional training 3 times a week for 10-15 minutes for 6 weeks. Pediatrics balance scale will be used to measure functional balance skills and GMFS scale will be used to measure gross motor function. The data will be assessed at the baseline and after 6 weeks of intervention. After data collection data will be analyzed by using SPSS version 25.

Eligibility Criteria:
Inclusion Criteria:

* • Children with cerebral palsy (Hemiplegic)

  * Age: 4 to 10 years
  * Able to sit without foot or arm support
  * Children with level I \& II on Gross motor function classification system
  * Normal cognitive function; can understand and follow command

Exclusion Criteria:

* • Children with mental retardation.

  * Visual and auditory disorders.
  * History of any surgical procedure.
  * Any infections, unstable seizures, etc.
  * Fixed deformities or contractures of lower limbs.
Evaluation of the Effect of Minimally Invasive Procedures Used in Management of Salivary Ductal Pathologies on Patients' Symptomatology and Gland Function

Aim of the current study was to evaluate the minimally invasive techniques in the management of salivary gland ductal pathologies


Eligibility Criteria:
Inclusion Criteria:

* All patients manifesting with either submandibular or parotid salivary gland ductal pathologies including:
* Sialolithiasis (salivary stones).
* Salivary ductal stenosis or stricture.
* Children with juvenile recurrent parotitis.
* Sjogren's syndrome.
* Radio-iodine induced sialadenitis.

Exclusion Criteria:

* Patients who are unfit for surgery.
* Patients with previous submandibular or parotid surgical resection.
* Patients with salivary tumors either benign or malignant.
Survey of Cannabis Use in Patients With Chronic Inflammatory Arthritis

Patients with inflammatory rheumatism very often have residual pain that is not easily relieved by conventional treatments. They can then use non-drug methods, such as physiotherapy, hypnosis or even cannabis.

The aim of this study is to assess the percentage of patients who use cannabis to better relieve their pain or anxiety in chronic inflammatory rheumatism.

Thanks to a better understanding of the pathophysiological mechanisms of inflammatory rheumatism, rheumatology has known for several decades a growth in its therapeutic arsenal (csDMARDs, bDMARDs, tDMARDs). rheumatism control has thus been optimized.

however, patients very often keep pain, anxiety, residual fatigue, poorly controlled by our conventional therapies. patients then turn to non-drug therapies, among which the use of cannabis.

endocannabinoids have an analgesic and anti-inflammatory action recognized in pre-clinical trials. however, investigators currently lack the data to authorize its use in clinical rheumatology.

the aim of this study is to determine the prevalence of cannabis users in patients with rheumatoid arthritis, ankylosing spondyloarthritis or psoriatic arthritis in our unit. as a second intention, investigators will refine the consumption characteristics. Investigators will also look for possible risk factors for consumption (sensitivity to pain, catastrophism, standard of living, anxiety, depression, rheumatic activity and quality of life).

Eligibility Criteria:
Inclusion Criteria:

* Rheumatoid Arthritis (ACR 2010 Criteria)
* Ankylosing Spondylitis (New york or ASAS criteria)
* Psoriatic Arthritis (CASPAR criteria)

Exclusion Criteria:

* Patient unable to complete questionnaires or unable to express informed consent
* Guardianship, trusteeship, deprivation of liberties, safeguard of justice
A Retrospective Analysis of the Effects of Red Light Therapy on Body Contouring

The purpose of this study is to determine whether red light therapy using LED 635nm red light for body contouring of the waist, hips and thighs is as effective as red light therapy using Laser 635nm red light.

Red light laser therapy using 635nm red light laser technology has previously been shown to cause lipolysis in subcutaneous fat as a non-surgical method to promote weight loss and body contouring. This study hypothesizes that red LED light therapy using 635nm red light LED (light emitting diode) technology produces similar results to the laser device (red LASER 635nm) when performed using a specified treatment protocol.

Furthermore, it is hypothesized that the UltraSlim Cold Light therapy program achieves the results after a single 32-minute treatment. The predicate 635nm laser device (Zerona by Erchonia) achieves its results after six treatments combined with a diet and exercise regimen.

UltraSlim Cold Light® is a patented process using the Photonica Professional device for fat removal using LED red light therapy. This multi-site study reviews results from 58 randomly selected patients after a single treatment using the Photonica Professional device (i.e. UltraSlim Cold Light®).

Eligibility Criteria:
Inclusion Criteria:

* 18 years or older.
* Male or female.
* Generally good health.

Exclusion Criteria:

* Pregnancy.
* Active cancer within the past year.
* Diminished ability to void waste (liver or kidneys).
* Photosensitive condition or medication.
Development and Validation of a Prediction Model for AKI Following Cisplatin-Based HIPEC in Patients With Ovarian Cancer

Ovarian cancer is the most lethal malignant tumor of the female reproductive system. Cytoreduction surgery(CRS) combined with chemotherapy is the primary method for treating ovarian cancer, and complete tumor resection is an important means to improve prognosis. It has been demonstrated that the use of cisplatin for hyperthermic intraperitoneal chemotherapy (HIPEC) following CRS can significantly improve the prognosis of some patients with ovarian cancer. However, HIPEC with cisplatin can lead to acute kidney injury (AKI), a serious complication that can seriously affect the patient's short- and long-term prognosis. NCCN guidelines recommend the use of sodium thiosulfate in all patients receiving HIPEC. This study intends to retrospectively collect clinical characteristics of patients to establish a prediction model for kidney injury, with a view to screening those at high risk of kidney injury for use of sodium thiosulfate for nephrotoxicity rescue in cisplatin HIPEC.


Eligibility Criteria:
Inclusion Criteria:

* Patients who received HIPEC with cisplatin following cytoreductive surgery.
* Patients diagnosed with ovarian cancer pathologically.
* FIGO stage III-IV.

Exclusion Criteria:

* Use of renal protective drugs such as sodium perthiosulfate.
* Any grade of chronic or acute renal disease or other serious complications existed before HIPEC.
* Patients with single kidney.
Recurrence in High-grade Lesions After Conization

Objectives: To identify factors associated with disease recurrence in patients with high-grade cervical intra-epithelial neoplasia (CIN) undergoing large loop excision of the transformation zone (LLETZ).

Study Design: A case-control study that included 103 patients. Patients were included in the study if they had a history of surgery for conization by LLETZ for the histopathological diagnosis of cervical intraepithelial neoplasia grades II and III (CIN II and CIN III). Follow-up exams were conducted every six months with Pap smear collection and colposcopic examination with biopsy, when necessary, for a minimum period of twelve months. Cure was defined as a normal follow-up examination within 24 months. During follow-up, relapse occurred when cytology and/or biopsy results showed that CIN had returned after 12 months, at which time a new cervical conization by LLETZ was performed.


Eligibility Criteria:
Inclusion Criteria:

1. history of surgery for conization

Exclusion Criteria:

1. under 18 years of age,
2. immunosuppressed,
3. Patient with a histopathological diagnosis of low-grade intraepithelial neoplasia
4. Patient with invasion, or surgical margins obtained by LLETZ that were unable to be evaluated.
The Effect of Different Simulation Methods Used in Adult Basic Life Support Training

Aim: The aim of this study, evaluating the effects of different simulation methods (virtual reality assisted simulation, high reality simulation, low reality simulation) used in Adult Basic Life Support (BLS) training on knowledge, skills, self-efficacy and satisfaction characteristics in Layperson First Aider

Aim: The aim of this study, evaluating the effects of different simulation methods (virtual reality assisted simulation, high reality simulation, low reality simulation) used in Adult Basic Life Support (BLS) training on knowledge, skills, self-efficacy and satisfaction characteristics in Layperson First Aider Material and Method: The population of the research consists of participants in the TYD and OED (Automatic External Defibrillator) training with participation certificate to be given to public institutions by the Ministry of Health in Ankara between 01.01.2024 and 10.03.2024. Power analysis was performed using the G\*Power (v3.1.9) program to determine the sample size. The medium effect size (d=0.45) used in a previous similar study was calculated at the end of the study as. Type I error α=0.05, Study power 1-β (β=Type II error probability) 0.8, and 3 groups were calculated by means of a statistical power analysis. The estimated total sample size of all intervention groups was 51. Considering that there may be losses during the study process, it was decided to recruit 20 people in each group.This study was designed as a prospective randomized controlled trial. As data collection tools: Introductory Characteristics Form, General Self-Efficacy Scale (GAS), Basic Life Support Knowledge Level Evaluation Form, Basic Life Support Application Skill Form, Basic Life Support Self-Efficacy Questionnaire and Basic Life Support Education Satisfaction Questionnaire were used.

Eligibility Criteria:
Inclusion Criteria:

* Voluntarily agreeing to participate in the research
* Being between the ages of 18-65
* Having applied for Basic life support and Automatic external defibrillator training with a participation certificate issued by the Ministry of Health.
* Being a Ministry of Health personnel.

Exclusion Criteria:

* Refusal to participate in the research
* Becoming a health professional
* Receiving previously authorized basic first aid training.
Evaluation of the Impact of Water Access and Promotion in Parks on Beverage Intake

Sugar-sweetened beverages (SSBs) are a major caloric source and the largest source of added sugars in the American diet. While many cities around the country have adopted anti-SSB policies such as soda taxes to reduce SSB intake, there has yet to be any studies to evaluate if the effects of these taxes, coupled with increased water access and promotion effort can lead to decreased sugar sweetened beverage consumption and increased water consumption. This quasi-experimental study evaluates how implementation of SSB taxes, installation of new water stations, and a multicultural water promotion campaign in parks impacts beverage intake in these settings as compared to soda taxes alone.

Consumption of water, in place of sugar sweetened beverages (SSBs), can help prevent obesity and dental carries. While drinking water is associated with these and many other positive health outcomes, many do not meet the recommended dietary intake of water. This is more profound in low income and minority communities that are more likely to drink less water and drink more SSBs. School-based water promotion interventions have shown that improved access to clean drinking water coupled with promotion leads to increases in water consumption and improved health outcomes. No studies have studied the impact of similar strategies on beverage intake and health in parks and public spaces. Parks are an inconspicuous and widely utilized public space, with the majority of Americans going to a park in the last month. This study's central hypothesis is that visitors in parks with SSB taxes coupled with increased access to appealing drinking water and rigorous promotion of its consumption will be more likely to drink water and less likely to drink SSBs, compared to visitors in parks with only SSB taxes. This quasi-experimental study makes use of naturally-occurring policy changes in the San Francisco (SF) Bay Area to disentangle the impacts of anti- SSB policies, water station installation, and multicultural water promotion efforts, using control groups to isolate the effects of anti-SSB policies alone or no intervention. This study will analyze beverage consumption in 10 SF parks that received new water stations and a multicultural water promotion campaign compared to 20 matched control parks (10 parks SF and 10 parks in Oakland) with only SSB taxes.

Eligibility Criteria:
Inclusion Criteria:

* Park visitors within a defined geographic boundary

Exclusion Criteria:

* Park visitors outside a defined geographic boundary
Sensorimotor Arm Rehabilitation After Stroke

Hemiparesis is a frequently observed symptom of stroke. There are various therapy options that are used in the rehabilitation of patients. Some studies have shown that, in addition to unilateral arm training, bilateral arm training can also lead to positive results in treatment and is a useful addition to therapy. The newly developed app requires the coordination of both arms in certain time sequences and intensities or rhythms and addresses different sensory modalities (visual, auditory and kinesthetic). The aim of the study is to examine whether tablet-based training improves bimanual coordination.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of an ischemic/hemorrhagic stroke
* moderate upper extremity paresis: 30 to 60 cubes in the Box-and-Block Test (BBT)
* sufficient resilience / alertness (active participation possible for at least 30 minutes)
* ability to give consent (written declaration of consent from the patient)

Exclusion Criteria:

* Hemianopia and/or neglect
* duration of illness \>3 months
* pre-existing hemiparesis
* participation in another clinical trial within the last 30 days
* a pregnancy or breast-feeding period
* contraindications for MRI: claustrophobia; metallic or magnetic implants that contain iron, cobalt or nickel (e.g. pacemakers, brain pacemakers, automatic insulin pumps, electrodes, plates, clips, implanted hearing aids, dental implants, metal endoprostheses, metal parts or metal splinters in the body)
Hemophilia Inhibitor Previously Untreated Patient Study

Hemophilia A is a congenital bleeding disorder caused by deficiency of factor VIII (FVIII) and is treated by replacement therapy with FVIII concentrate. Approximately 30% of people with severe hemophilia A develop neutralizing antibodies, called FVIII inhibitors, which interfere with the function of FVIII concentrates. The reason that some, but not all, people with severe hemophilia A develop inhibitors is incompletely understood. Understanding individual and environmental risk factors is important to be able to prevent and possibly treat inhibitors. This study will look at individual and treatment characteristics in babies with severe hemophilia A who have not yet received treatment with FVIII (called Previously Untreated Patients, or PUPS). Subjects in the study will be asked to provide diaries of treatments, medications, and illnesses. Treatment will be directed by the subjects' physician, but all subjects will receive Advate, a third-generation recombinant FVIII product. Subjects will have blood drawn for laboratory tests, which include studies of the immune system and genetic studies of the FVIII mutation, before and 7-9 days after the first treatment with FVIII, and 5 days (+/-2 days) after the 5th, 10th, 20th, 30th, 40th, and 50th days of treatment with FVIII (exposure days). The duration of the study will be first 50 treatments or 3 years, whichever comes first.


Eligibility Criteria:
Inclusion Criteria:

* Severe hemophilia A with FVIII activity \< 1% normal
* Weight \> 3.5 kg at the time of baseline study evaluation
* Informed consent, approved by appropriate Institutional Review Board/Independent Ethics Committee, has been administered, signed, and dated

Exclusion Criteria:

* Prior exposure to clotting factor concentrates or blood products
* Other chronic disease
* Currently participating in another investigational drug study.
Nonrestorative Sleep RSQ (Restorative Sleep Questionnaire) Development-- Methodology Study

To begin to refine development of the RSQ (Restorative Sleep Questionnaire) measure in subjects with NRS (Nonrestorative Sleep) by generating item content pertaining to morning refreshment and uncovering problems in instrument administration in subjects with nonrestorative sleep

Study was terminated on January 20, 2009 due to portfolio decision by Pfizer to discontinue further investigation of PD200390 for non-restorative sleep. The decision was not based on any safety concerns.

Eligibility Criteria:
Inclusion Criteria:

* Subjects who self report nonrestorative sleep but no problems either getting to sleep or staying asleep
* Complaints of significant distress or impairment in social, occupational, or other important areas of functioning during daytime for at least 3 nights per week
* Self reports sWASO (Wake after sleep onset) for \<45 minutes for past 3 months, self reports LPS (latency to persistent sleep onset ) for \<20 minutes for past 3 months (then neither PSG (polysomnography) screening night showing WASO \>45min, or LPS \> 20 minutes)
* Customary bedtime betw. 9 pm and midnight and rise between 4 and 9 AM

Exclusion Criteria:

* Psychiatric disease or disorder as determined by current administration of the MINI (Mini International Neuropsychiatric Interview)
* History or presence of any breathing-related sleep disorder, narcolepsy, or any other dyssomnias or any parasomnia, or restless legs syndrome MAP \> 0.5 at screening
* History or presence of any medical or neurological condition that could interfere with sleep (chronic pain, Restless leg, etc)
* Current use of meds wth known psychotropic effects or known or suspected effects on sleep
* Alcohol or substance abuse (unless in remission for at least a year
* Excessive caffeine use (or any use after 6 pm for at least 3 months
* Regular napping or any naps after 6 pm
* Excessive cigarette or cigar smoking over the last 3 months
* no participation in an investigational new drug study within 30 days of screening, and no previous participation in a study of PD200390
* No night or rotating shift work
Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea

Phase 3 efficacy and safety study of CD07805/47 topical gel in subjects with facial erythema associated with rosacea. The study hypothesis is that CD07805/47 gel, applied topically once daily is more efficacious than vehicle and provides an acceptable safety profile in the treatment of facial erythema associated with rosacea.


Eligibility Criteria:
Key Inclusion Criteria:

1. Male or female who is at least 18 years of age or older.
2. A clinical diagnosis of facial rosacea.
3. A Clinician Erythema Assessment (CEA) score of greater than or equal to 3 at Screening and at Baseline/Day 1 (prior to the study drug application).
4. A Patient Self Assessment (PSA) score of greater than or equal to 3 at Screening and at Baseline/Day 1 (prior to the study drug application).

Key Exclusion Criteria:

1. Particular forms of rosacea (rosacea conglobata, rosacea fulminans, isolated rhinophyma, isolated pustulosis of the chin) or other concomitant facial dermatoses that are similar to rosacea such as peri-oral dermatitis, demodicidosis, facial keratosis pilaris, seborrheic dermatitis, acute lupus erythematosus, or actinic telangiectasia.
2. Presence of three (3) or more facial inflammatory lesions of rosacea.
3. Current treatment with monoamine oxidase (MAO) inhibitors, barbiturates, opiates, sedatives, systemic anesthetics, or alpha agonists.
4. Less than 3 months stable dose treatment with tricyclic antidepressants, cardiac glycosides, beta blockers or other antihypertensive agents.
5. Current diagnosis of Raynaud's syndrome, thromboangiitis obliterans, orthostatic hypotension, severe cardiovascular disease, cerebral or coronary insufficiency, renal or hepatic impairment, scleroderma, Sjögren's syndrome, or depression.