cyrilzakka/clinical-trials huggingface dataset:
Dietary Reporting in the Amyloidoses

The goal of this clinical trial is to learn about malnutrition and weight loss in patients with Amyloidosis.

The main question it aims to answer is:

Is it feasible to use a low-cost nutrition-based application (apps) for use on a smartphone to obtain detailed information on caloric intake in Amyloidosis patients

Participants will be asked to:

* Download the MyFitnessPal application on their smartphone and view an online tutorial
* After a week of practice, from weeks 2-9, participants will enter daily dietary intake as well as daily herbal/alternative supplement intake into the MyFitnessPal application on their smartphone.
* complete a questionnaire prior to starting the application, after week 2 and at week 10 after starting the application


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* Diagnosed with any type of amyloidosis
* Speak, read and write in English
* Willing to use the MyFitnessPal app on their own smartphone

Exclusion Criteria:

* a planned autologous stem cell transplant or a solid organ transplant in the 12 weeks after enrollment
* cognitive or perceptual disturbances
Synchronous and Asynchronous Telerehabilitation Methods in Patients With Shoulder Tendinopathy

This study is a randomized controlled trial conducted to compare the effects of synchronous and asynchronous telerehabilitation programs on pain, disability, and quality of life parameters in patients with shoulder tendinopathy in the Marmara University Physiotherapy and Rehabilitation Department.


Eligibility Criteria:
Inclusion Criteria:

* Participants between the ages of 18-65,
* Who had access to the internet and smartphone,
* Had the ability to conduct video calls included in the study.

Exclusion Criteria:

* Participants were excluded if they had COVID-19,
* Had surgery in the last 6 months,
* Had neurological and psychological disorders,
* Received physiotherapy treatment.
* Had surgery in the last 6 months,
* Had a condition that prevented them from exercising.
Measuring Droplets in Children

This study will measure the size and quantity of respiratory particle production in children under a variety of conditions, including face coverings/masks and various common activities.


Eligibility Criteria:
Inclusion Criteria:

- Age 3 to 17 years

Exclusion Criteria:

* Chronic neuromuscular conditions that affect respiration
* Tracheostomy tube
* Unable to wear a face mask
ProSpectic Italian Laparoscopic Hybrid mEsh hErnia Repair in Obese patientS Trials

The aim of this study is to evaluate safety and effectiveness of a hybrid mesh (GORE® SYNECOR Intraperitoneal Biomaterial) in patients with a BMI of 30 kg/m2 or more undergoing laparoscopic ventral hernia repair (LVHR) with intraperitoneal position of the mesh.

A prospective Italian multicenter observational trial will be conducted in 8 different Italian centers to compare the effectiveness and feasibility of treatment of Incisional Hernia with GORE® SYNECOR Intraperitoneal Biomaterial mesh in patients with BMI \>30 kg/m2. This study was reviewed and approved by the local regional Ethics Committee. The study adhered to the CONSORT guidelines in reporting this trial's results

Eligibility Criteria:
Inclusion Criteria:

* age \> 18 years
* Clean wounds
* Informed consent
* Patients affected by Incisional and Ventral Hernia
* Elective surgery
* Hernia size between 3 e 7 cm
* BMI \> 30 kg/m2

Exclusion Criteria:

* age \< 18 years;
* Life expectancy \< 24 months (as estimated by the operating surgeon), -
* Pregnancy
* Immunosuppressant therapy within 2 weeks before surgery
* Clean-contaminated and contaminated, dirty wounds
* Cirrhosis
Genetic Determinations for Side Effects and Response Rate for Patients Receiving Chemotherapy With Diffuse Large Cell Lymphoma

The purpose of this study is to determine whether people have genes that make them more likely to respond to chemotherapy and/or have side effects from chemotherapy for diffuse large cell lymphoma.

Upon enrollment in the study, patients will have a blood sample collected for genotyping of the FCGR3A gene (immunoglobulin Fc G receptor IIIa), the ABCB1 gene (ATP Binding Cassette Beta 1; also called MDR1), and other candidate genes. Patients will be treated with R-CHOP for six cycles, which is standard therapy for advanced stage DLCL. Response will be monitored by an FDG-PET scan performed after 2 cycles of R-CHOP and restaging exams performed upon completion of chemotherapy. Gene polymorphisms will be analyzed to establish which polymorphisms predict response to R-CHOP.

Eligibility Criteria:
Inclusion Criteria:

* Histologically proven diffuse large B-cell non-Hodgkin's lymphoma according to the WHO classification, with measurable or evaluable disease
* No prior therapy for NHL. Patient may be enrolled in this study after the first cycle of R-CHOP if all screening evaluations were performed prior to the first cycle of chemotherapy.
* Ann Arbor stage 3 or 4
* Age greater than or equal to 18 years
* Patient must give written informed consent.
* A patient enrolled in another clinical trial may also enroll in this study if the other trial has an R-CHOP treatment arm and the patient is randomized to the R-CHOP only arm. Registration to this study must occur after randomization in the other trial.

Exclusion Criteria:

* CNS involvement
* Known HIV positive
* T-cell lymphoma or history of indolent NHL
* Patients who will be treated with radiation therapy
Effects of Contrast Media on Subjects With Stable Reduced Renal Function Undergoing Contrast-Enhanced Computed Tomography

The purpose of this study is to evaluate the contrast-induced nephropathy (CIN) rate in subjects randomized to receive either Ioversol or Iodixanol for contrast-enhanced computed tomography.

Contrast-induced nephropathy (CIN) is an acute decline in renal function after the administration of iodinated contrast agents. CIN is commonly defined as an increase in post contrast serum creatinine (SCr) greater than or equal to 25% or an absolute increase greater than or equal to 0.5 mg/dL from pre contrast baseline values. Study will evaluate and compare the effects of two (2) contrast media products on renal function in subjects with stable reduced renal function while undergoing contrast-enhanced computed tomography.

Eligibility Criteria:
Inclusion Criteria:

* Males and females 18 years of age or older
* Subjects scheduled for a clinically indicated CECT requiring 40 grams of iodine (125 mL)
* Subjects have an abnormal screening SCr that results in a calculated eGFR of \< 60 mL/min/1.73 m2 using the MDRD formula and acute causes for an elevation in SCr have been excluded
* Subjects have stable reduced renal function which is defined as an abnormal screening SCr measurement with a \< 15% difference from the oldest historical SCr measurement obtained within the proceeding 1 week to 12 weeks
* Subjects must provide written consent and agree to abide by the site and study requirements

Exclusion Criteria:

* Subjects previously entered into this study
* Subjects on dialysis
* Subjects received any investigational drug within 30 days of contrast administration or participated in an investigational study within 30 days prior to study enrollment
* Subjects have undergone a procedure using iodinated or gadolinium contrast agent within 7 days prior to contrast administration, or is scheduled to receive additional doses of contrast agents during the 48-72 hour post-study contrast administration
* Subjects in acute renal failure or have one or more known causes of acute renal failure
* Subjects have known or suspected unstable renal function
* Subjects scheduled for a surgical intervention or other procedure within 72 hours after the contrast administration
* Subjects taking NSAIDs (with the exception of ASA) and/or any type of diuretics who cannot discontinue these drugs post contrast administration and hold all subsequent doses until the 48-72 hour post contrast SCr has been drawn
* Subjects taking aminoglycosides
* Subjects known to have an organ transplantation
* Subjects have severe congestive heart failure (Class III-IV)
The Effect of Osteopathic Treatment in Pain and Functionality Individuals With Chronic Neck Pain

The purpose of this study is to determine whether manipulative osteopathic treatment associated exercises improves pain and function in individuals with chronic non-specific neck pain

The purpose of this study is to determine whether manipulative osteopathic treatment associated exercises improves pain and function in individuals with chronic non-specific neck pain Design: a randomized single blind placebo controlled trial will be conducted trial. Patients (n=40) with non-specific neck pain will be randomized to receive 1) osteopathic manipulative treatment and exercise (n=20) or 2) exercise alone (n=20). Participants will receive 8 treatments during 4 weeks.

Clinical outcomes will be obtained at 1 week, four weeks and 24 weeks after end of treatment.

Methods:

The primary outcome will be pain measured by 11-point numerical pain rating scale.

The secondary outcome will be disability measured by the Neck Disability Index, range of motion measured by Cervical Range of Motion device, Pressure pain threshold measured by electronic algometer.

Eligibility Criteria:
Inclusion Criteria:

Symptoms of chronic neck pain does not specify that persists for more than 3 months

Exclusion Criteria:

individuals who report inflammatory previous surgery, spondylolisthesis, spinal stenosis, herniated disc, radiculopathy, fracture and musculoskeletal degenerative diseases. , Cancer, neurological diseases, pregnancy. They will be excluded participants who received some form of manipulative treatment in the last three months.
The Effect of Sugar Load in IBS Patients Depending on Sucrase-isomaltase Genes

The investigators know that many patients with irritable bowel syndrome (IBS) have functional variants of genes coding for sucrase-isomaltase enzymes. The investigators will now examine whether these functional variants are associated with defect degradation of sucrose and associated gastrointestinal symptoms

The investigators have in a previous study included IBS patients for treatment with a starch- and sucrose reduced diet (SSRD). The investigators found a great improvement of symptoms. The investigators gene-tested those patients, and now have the full identification of all functional variants encoding sucrase-isomaltase enzymes.

The investigators will invite patients from this previous study with normal genes and functional variants of genes. The patients will come fasting over night to the department of clinical research. The participants will ingest 75 g sugar dissolved in 0.8 dl water and flavored with lemon, to ingest during 5 minutes. After that, glucose will determined repeatedly up to 2 hours afterwards. At the same time, the participants have to assess their gastrointestinal sympotms on visual analogue scales (VAS).

The investigators will compare the raise in b-glucose and symptoms between the groups of patients, divided into gene expression.

Eligibility Criteria:
Inclusion Criteria:

* Participants of our previous clinical trial with SSRD diet (NCT03306381)

Exclusion Criteria:

* Difficulties in taking blood samples
Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or Colon Cancer

This pilot research trial studies characterization of mechanical tissue properties in patients with pancreatic, liver, or colon cancer. Mechanical properties and stiffness of the cancerous tissue may be correlated with the standard pathology report that describes the stage of the disease.

PRIMARY OBJECTIVES:

I. To determine if our optical polarimeter device is able to measure tissue stiffness across several human cancer types ex vivo.

SECONDARY OBJECTIVES:

I. To describe the inter- and intra-tumor heterogeneity of tissue stiffness. II. To determine if the measurements made by the optical polarimeter device are non-destructive.

TERTIARY OBJECTIVES:

I. Perform multi-variable cross-correlation statistical analysis to determine relationships between: tissue stiffness characteristics, molecular level signatures, and cellular level properties, and if numbers permit, response to treatment.

OUTLINE:

Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue samples are analyzed for tissue stiffness measurements using an optical polarimeter device and cell viability using an automated cell counter.

Eligibility Criteria:
Inclusion Criteria:

* Scheduled for surgery to remove primary tumors in the pancreas, liver or colon and have not undergone any prior treatment
* Ability to understand and the willingness to sign a written informed consent

Exclusion Criteria:

* Pregnant women will not be consented
* Patients that are unable to consent for surgery
* Primary liver tumors with cirrhosis will be excluded from this study
The Effect of Laughter Yoga on Mindfulness, Proffessional Resilience and Self-Care

The aim of this study was to evaluate the effect of laughter yoga on mindfulness, professional resilience and self-care among nurses. The hypotheses of the study suggested that laughter yoga would have an effect on mindfulness, professional resilience and self-care scores among nurses.

Laughter yoga is an independent nursing intervention that includes breathing and laughter exercises. Studies have proven that laughter yoga decreases stress hormones, increases hormones such as endorphins, decreases leukocytes and provides protection against infection, accelerates circulation, increases pain tolerance and quality of life, decreases blood pressure, stress, anxiety and tension, improves mental well-being and self-esteem, improves memory and creative thinking skills, and strengthens interpersonal communication. Many of these studies have been conducted in patients, healthy adults, the elderly, nursing and university students. There are a limited number of studies in which laughter yoga was applied as an intervention in a sample of nurses. In the studies, it was determined that laughter yoga decreased cortisol hormone, fatigue levels, perceived stress, burnout levels, increased life satisfaction, attention levels and individual work performance, psychological resilience and sleep quality in nurses.

Purpose: The aim of this study was to evaluate the effect of laughter yoga on mindfulness, professional resilience and self-care among nurses.

Method:

The study is planned as an experimental research with a randomized controlled pretest-posttest control group. This study is planned to be conducted in Düzce Atatürk State Hospital between February 2024 and December 2024.

The sample size for the study was calculated using the G\*Power 3.1.9.7 program. There was no article that could be taken as a reference for the scales included in this study. Therefore, taking a medium effect level (d=0.5), 5% margin of error (α=0.05), 80% power (1β=0.80) and 1:2 intervention-control group ratio, the number of people who should be included in the study according to the one-way hypothesis was found as 38 participants for the intervention group and 76 participants for the control group. Assuming drop outs, the sample size will be determined as 40 participants for the experimental group and 80 participants for the control group.

The data will be collected through "Personal Information Form", "Five Dimensional Mindfulness Scale", "Skovholt Professional Resilience and Self-Care Inventory" and "Post Laughter Yoga Evaluation Form

Eligibility Criteria:
Inclusion Criteria:

* Volunteering to participate in the study
* Working as a nurse at Düzce Atatürk State Hospital
* Not doing laughter yoga before

Exclusion Criteria:

* Currently being in the process of any psychiatric treatment or psychotherapy
Goal-oriented Intervention in Parkinson's Disease

Upper-limb disorders in patients with Parkinson's disease include decreased speed and amplitude of movements, difficulty in sequential tasks, and disrupted execution of fine manipulative hand activities.The aim of the study was to evaluate the effects of home-based goal-oriented upper limb intervention in patients with Parkinson's disease.

Parkinson's disease is a neurodegenerative neurological disorders involving progressive impairment in motor, mood and cognitive functions. Movement disorders have a negative impact on individual's ability to perform well-learned motor skills. These include akinesia, bradykinesia, rigidity and tremor at rest.

A goal-planning process should be useful to ensure that patients agree on the goals of rehabilitation. Thus, the purpose of the study was to evaluate the effects of home-based goal-oriented upper limb intervention in patients with Parkinson's disease.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of Parkinson's Disease.
* Stage II-III of disease progression as defined by the Hoehn and Yahr scale.
* Upper limbs impairment

Exclusion Criteria:

* Clinical signs of dementia or psychiatric disturbance.
* Comprehension deficits that prevented them from following verbal commands.
* Visual or acoustic limitations.
* A neurologic condition other than Parkinson's Disease.
* Musculoskeletal disorders and/or if they had previous trauma or fracture of upper extremity.
Molecular Landscape of Microvascular Inflammation in Kidney Allografts

Microvascular inflammation in kidney allografts has been widely reappraised in the recent update of Banff classification. There is a critical need to better understand the pathophysiological mechanisms associated with the various phenotypes of microvascular inflammation that are observed in kidney transplants, particularly in order to develop targeted therapeutic approaches.

Antibody-mediated rejection is a major cause of graft failure in kidney transplant recipients. The diagnostic criteria for antibody-mediated rejection have undergone significant changes since their initial definition in the international Banff Classification system. The Banff 2022 Classification update reappraises lesions of microvascular inflammation and identifies new phenotypes for cases with microvascular inflammation. However, pathophysiological mechanisms associated with microvascular inflammation in kidney allografts are still poorly understood, thus hampering the development of efficient treatments.

The aims of this study are:

1. To decipher the spatial immune-molecular landscape of microvascular inflammation in kidney allografts.
2. To compare the characteristics of this landscape in different clinical scenarios.

The investigators will use a multimodal phenotyping approach including histological analyses and multiplex immunostainings, bulk transcriptomic analyses and spatial whole-transcriptome digital profiling to decipher the molecular landscape of microvascular inflammation in kidney allografts. Based on these results, they will investigate its association with allograft outcomes and search for molecular targets which could benefit from targeted therapeutic strategies.

Eligibility Criteria:
Inclusion Criteria:

- Adult kidney transplant recipients, with at least one kidney transplant biopsy performed and assessed according to the international Banff 2022 classification, with or without lesions of microvascular inflammation

Exclusion Criteria:

* Inadequate biopsy according to the Banff classification
* Missing data for Banff lesion scores, donor-specific antibody status, C4d staining
* Biopsies showing histological signs of ischemia-reperfusion
* Combined transplantation and kidney transplantation after a non-kidney solid organ transplantation
Effect of Ankle-foot Orthoses Trim Line Modifications on Ankle and Knee Motion and Force.

The purpose of this study is to quantify changes in ankle and knee motion and force resulting from five progressive modifications to the anterior-posterior trim lines of thermoformed ankle-foot orthoses (AFO). It is hypothesized that the AFO with the most anterior trim line will prevent the most plantar flexion during loading response (the first 10% of the gait cycle)and prevent the most dorsiflexion at terminal stance (from 30 to 50% of the gait cycle) as compared to the non-device condition. This will be evidenced by the sagittal plane ankle motion and ground reaction force magnitude and location during loading response and terminal stance. Additionally, the angular velocity of knee flexion will increase during these same periods. By contrast, as the trim lines are moved more posterior this will result in lowering the effective stiffness of the device which will result in progressive increases in dorsiflexion and allow increasing amounts of knee flexion during terminal stance.


Eligibility Criteria:
Inclusion Criteria:

* Participants must have no known pathology that would affect their ambulatory ability.
* Age greater than or equal to 18 years, but less than 40 years.
* Ability to tolerate walking for a minimum of 100 yards over the course of a three and a half hour time period.
* No current skin breakdown or sores on either lower extremity.

Exclusion Criteria:

* Use of ambulatory aids such as canes or crutches.
* Any medical or psychological condition that could jeopardize the subject's participation and compliance with the study protocol.
Clinical Investigation to Assess the Efficacy and the Safety of VisuXL® Gel Administered in Patients Affected by Moderate DED

This is a post-market, european multicenter study. This is a randomized, cross-over, double blind study with competitive enrolment, aimed to enroll a total of 90 patients with a diagnosis of moderate dry eye disease (DED).

The purpose of the study is to evaluate the non-inferiority of the new treatment versus the comparator.

Patients, after signing the Informed Consent, will enter into a 1-week screening phase during which the baseline tests will be conducted.

Baseline (V0), Day 30 ± 1 week (V1), Day 38 ± 2 days (V2), Day 68 ±1 week (V3) of treatment.

Between V1 and V2 one week of wash out should be performed. Of note, all ophthalmologic evaluations listed in the Flow-Chart will be performed on both eyes of the patient.

Eligibility Criteria:
Inclusion Criteria:

* Patient Informed consent form (ICF) signed.
* Males and Females aged ≥18 years at the time of the signature of ICF.
* Patients with moderate dry eye disease (DED) according to IDEEL questionnaire (score ≥51 and ≤64) and diagnosed at least 3 months before enrolment.
* No use of other tear substitutes in the 5 days prior to enrolment, except for refresh solutions.
* TBUT value \<6 sec.
* Willing to follow all study procedures, including attending all site visits, tests and examinations.
* Women must agree to be using two forms of effective contraception, be post-menopausal from at least 12 months prior to trial entry, or surgically sterile.

Exclusion Criteria:

* Patients with a mild or severe dry eye disease (DED) according to IDEEL questionnaire (score ≤50 and ≥65, respectively).
* Use of ophthalmologic products in the 14 days prior to enrolment, except for refresh solutions and stable glaucoma treatment.
* No previous history or presence of any disease involving cornea or conjunctiva.
* Sjӧgren syndrome.
* History or active cicatricial conjunctivitis.
* History of ocular surface burns.
* Use of contact lenses.
* Corneal refractive surgery 1 year post-operative.
* Any ocular surgery in the previous 3 months preceding the study.
* Unstable glaucoma (treatment changes in the last year).
* Any macular or retinal disease that could impact visual acuity.
* Best corrected visual acuity (BCVA) below 20/40.
* Blepharitis treatment started less than 3 months before enrolment.
* Neurological, neurodegenerative or cerebrovascular conditions.
* Any clinically significant history of serious digestive tract, liver, kidney, cardiovascular, cancer or hematological disease.
* Unstable treatment with systemic medications, such as diuretics, antihistamines, antidepressants, psychotropics, cholesterol lowering agents and beta-blockers.
* Known hypersensitivity to one of the administered products.
* Known drug and/or alcohol abuse.
* Mental incapacity that precludes adequate understanding or cooperation.
* Participation in another investigational study or blood donation within 1 month prior to ICF signature.