cyrilzakka/clinical-trials huggingface dataset:
Simo Decoction and Gum Chewing for Bowel Activity

Abdominal surgery, including hepatic resection for hepatocellular carcinoma (HCC), is inevitably followed by an episode of gastrointestinal hypomotility. A delayed return of gastrointestinal function, defined as postoperative ileus (POI), has a great impact on patient comfort, morbidity and recovery. POI often results in a prolonged hospital stay and contributes significantly to healthcare costs.

Some prospective studies have revealed that gum chewing can improve the return of gastrointestinal function after colorectum surgery, gynaecology and obstetrics, and urinary system surgery. Moreover, some retrospective studies also revealed that simo decoction may improve the return of gastrointestinal function after hepatic resection of HCC. Therefore, the present study compared the effect of gum chewing and simo decoction after hepatic resection of HCC on POI, surgical complications, and length of hospital stay.


Eligibility Criteria:
Inclusion Criteria:

* Underwent open hepatic resection
* Diagnosis of HCC was confirmed by histopathological examination of surgical samples in all patients

Exclusion Criteria:

* Previously underwent exploratory laparotomy
* Laparoscopic surgery
* Known Central Nervous System tumors including metastatic brain disease
* History of organ allograft
* Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results
* Any condition that is unstable or which could jeopardize the safety of the patient and his/her compliance in the study
* Pregnant or breast-feeding patients
Treatment of Major Depressive Disorder With Bilateral Theta Burst Stimulation

This is a randomized, double-blind, sham-controlled multicenter clinical trial. The aim is to provide evidence for efficacy of TBS in the treatment of patients with major depression. There will be a direct comparison between combined cTBS/iTBS with sham TBS. Overall, 236 patients with major depression will be randomized either to active TBS or sham TBS in a 1:1 ratio. The planned stimulation paradigms will be applied as add-on therapy to standard therapy (antidepressive medication and / or psychotherapy). Patients will receive 30 stimulation sessions in a 6-week treatment period (one session daily from Monday to Friday). Follow up assessments are scheduled 1 and 3 months after end of treatment period.


Eligibility Criteria:
Inclusion Criteria:

* moderate or severe unipolar depression diagnosed according to criteria of Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5)
* duration of the current episode must be ≥ 6 weeks and ≤ 2 years
* HDRS17 ≥ 18
* mild to moderate treatment resistance according to the Antidepressant Treatment History Form \[ATHF-SF\]. Treatment resistance is defined as having failed at least one but no more than three adequate antidepressant treatments in this episode
* stable antidepressive medication 4 weeks before treatment or no antidepressive treatment
* no further relevant psychiatric axis-I and/or axis-II disorder except for anxiety disorders (according to DSM-5 and SCID-5-PD)
* no comorbid psychotic symptoms
* ability to give consent

Exclusion Criteria:

* acute suicidality (MADRS item 10 score \> 4)
* antiepileptic drugs and/or benzodiazepines corresponding to \> 1mg lorazepam / day
* history of brain surgery, significant and clinically relevant brain malformation or neoplasm, head injury, stroke, dementia or other neurodegenerative disorder
* history of seizures
* previous rTMS treatment
* lifetime history of non-response to adequate electroconvulsive therapy (minimum of eight treatments)
* deep brain stimulation
* cardiac pacemakers, intracranial implant, or metal in the cranium
* substance dependence or abuse in the past 3 months (with the exception of tobacco)
* severe somatic comorbidity as judged by the study physician
* pregnancy
Different Re-training Durations in BLS Training Among Non-Professionals

Previous studies on compression-only CPR and AED training for the general public have primarily focused on the optimal retraining interval. However, the impact of different retraining durations remains unclear. This study explores how varying practice durations in Basic Life Support (BLS) training affect BLS performance among non-professionals.

In this study, participants first underwent compression-only CPR and AED training. Before training, they completed a questionnaire on their perspectives on BLS retraining and basic demographic information. Knowledge tests, skill assessments, and attitude and confidence questionnaires were conducted both before and after training. During the skill assessment, two cameras recorded the process from different angles: one positioned from the feet towards the head of the manikin and the other from the left chest towards the right chest. Instructors, blinded to group allocation, later reviewed the recordings and assessed participants' performance using an evaluation form. Additionally, chest compressions were recorded using a computerized manikin (SkillReporter Resusci Anne®, Laerdal, Stavanger, Norway).

Participants were then randomly assigned to one of three groups based on different retraining durations:

1. 45-minute retraining sessions
2. 60-minute retraining sessions
3. 75-minute retraining sessions

All three groups underwent skill assessments and knowledge tests every three months before their respective retraining sessions. The retraining skill assessments followed the same procedure as the initial training. Each retraining session began with a 15-minute comprehensive review, followed by hands-on practice. Each participant practiced for approximately five minutes per cycle, which included two minutes of chest compressions, one minute of AED application, one minute of feedback, and one minute for role-switching. Based on this structure, participants in the 45-minute group completed two practice cycles, those in the 60-minute group completed three cycles, and those in the 75-minute group completed four cycles.

Both the initial training and retraining followed the American Heart Association (AHA) Heartsaver® CPR+AED course guidelines, with a participant-to-manikin ratio of 3:1 and a maximum of six participants per instructor. One year after the initial training, before the final skill assessment, participants completed the knowledge test and the attitude and confidence questionnaire. After the final skill assessment, they completed the CPR retraining perspectives questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* Age \>=18 years old

Exclusion Criteria:

* Subjects whose physical condition is unsuitable for the CPR training, such as those unable to squat, extend their arms fully, or individuals who are blind or deaf.
* Healthcare professionals and students majoring in healthcare-related fields.
* Individuals unwilling to sign the informed consent form
BOUNCE to Health: A Healthy Lifestyle Program

The primary purpose of the BOUNCE study is to assess the effectiveness of a four-week family-based healthy lifestyle summer program in reducing adiposity indicators in Hispanic and African American girls and boys (ages 9-14 years old).

The secondary aims of this study are to examine post-intervention changes in eating patterns, body image disturbances, unhealthy weight control practices, and fitness levels.

The investigators hypothesize that at the post-BOUNCE summer intervention, children will exhibit significant decreases in adiposity indicators (percent body fat and waist circumference), sweetened drinks and fried foods consumption, and an increase in physical fitness (aerobic capacity and minutes of moderated-vigorous physical activity) when compared to their baseline values after controlling for demographic, acculturation characteristics.

Eligibility Criteria:
Inclusion Criteria:

* Both parental guardians (mother and father) and target child must be of Hispanic or African American descent
* Child must be between the ages of 9-14 years
* Child must be overweight/obese as defined by a body mass index percentile for age- gender specific between the 85th-100th percentile
* Child must have no physical disability or medical conditions that interfere with their participation in an exercise program
* Children must have no extensive diet restrictions that would hinder their participation in the BOUNCE nutrition component (e.g., unable to eat solid foods)
* All children will be required to submit evidence of a medical examination conducted by a health professional
* Parental guardians and child must be available to participate for the duration of the BOUNCE summer

Exclusion Criteria:

* Child and parental guardians are not Hispanic or African American
* Child is not between the ages of 9-14 years
* Child is underweight or normal weight (BMI \< 85 percentile) or are morbidly obese (BMI \> 100 percentile)
* Child or mother are pregnant or physically unable to participate
* Child has extensive diet restrictions that would hinder their participation in the BOUNCE nutrition component (e.g., unable to eat solid foods)
* Child does not have submitted evidence of a medical examination conducted by a health professional

Note: We will encourage both maternal and paternal guardians to participate in the measurements and interventions. However, if the paternal guardian refuses to participate or there is no father figure present in the family, maternal guardian-child pairs will be still eligible to participate in this study. If the children are of mixed race, but identify themselves as Hispanic or African American and at least one of their parents is either Hispanic or African American, they will be still eligible to participate.
Predictive Value of a SNP Signature and Liquid Biopsy in Natural Killer T-cell Lymphoma

The purpose of this study is to determine the Predictive value of a SNP signature and liquid biopsy in patients with natural killer T-cell lymphoma.


Eligibility Criteria:
Inclusion Criteria:

* biopsy proved Natural Killer T-cell Lymphoma
* newly diagnosed patients

Exclusion Criteria:

* patients with biopsy samples unavailable
Teachers Thriving Together

This is a randomized, controlled, hybrid implementation-effectiveness design.whose primary aim is to examine the impact of ParentCorps plus Thrive Professional Learning, relative to Thrive Professional Learning and Inspire Professional Learning alone, on teachers' classroom teaching (knowledge, beliefs, skills and practice related to family engagement and social emotional learning) and teachers' social emotional development. The study also aims to understand the impact of Thrive Professional Learning versus Inspire Professional Learning alone on teachers and classrooms.


Eligibility Criteria:
Inclusion Criteria:

* The participants are lead teachers, assistant teachers, teaching assistants, paraprofessionals and teacher aides in 238 sites with Pre-K in NYC (for the purposes of this study, the term "teachers" will be used to represent this group). The inclusion criteria include teachers who participate in Thrive or Inspire Professional Learning in 2018-2019. Additionally, 449 teachers from 81 district schools (that are part of the Thrive and Inspire Professional Learning) are were randomized into the study will participate.
* To be eligible for the study, sites met the following criteria: a) have 2 or more PKFA classrooms; b) serve a high-need population and c) leaders ranked Thrive or Inspire as a first or second preference for the school. "High need" was defined as follows: the site level percentage of students in poverty was above the median of the eligible pool; the site level percentage of students in poverty was in the second quartile of the eligible pool and two or more students were listed as living in temporary housing; and/or the site level percentage of students in poverty was in the first quartile of the eligible pool and 5 or more students were listed as living in temporary housing.

Exclusion Criteria:

* Sites that were currently implementing ParentCorps at the time of the randomization were not eligible for the study. Only teachers who were part of the Thrive or Inspire Professional Learning tracks in 2018-2019 will be eligible.
Goitres Influence on Voice Function - The Impact of Surgery

The aim of the study is to investigate the influence benign non-toxic goitre and the surgical treatment hereof on the voice function before and 6 months following surgery.


Eligibility Criteria:
Inclusion criteria:

* Patients undergoing hemi- or total thyroidectomy for benign non-toxic goiter with pressure symptoms
* The patients must be able to understand, write and read Danish

Exclusion criteria:

* Previous surgery to the neck
* Diabetes or any neuromuscular disorders.
* Present or previous head and neck malignancy, including malignancy found in the surgical thyroid specimen or suspicion hereof.
The Effect of Hypermobility Healthy Individuals

Benign Joint Hypermobility Syndrome is a hereditary connective tissue problem characterized by the emergence of multiple musculoskeletal problems in hypermobile individuals without a systemic rheumatologic disease. Studies have shown that hypermobility may also affect lung function. Playing wind instruments requires tiring breathing activity. The effect of wind instrument on lung function and how it affects lung function is a highly controversial issue. Given the distribution and importance of collagen tissue in the body, multiple effects of hypermobility are inevitable. The aim of this study was to evaluate the presence of hypermobility in young healthy individuals; The aim of the study is to investigate the effects of hypermobility on the cardiovascular system and to provide training to the participants regarding the findings.The aim of this study is to investigate the relationship of hypermobility with respiratory functions in professional hypermobile musicians and to compare this relationship with healthy hypermobile individuals who are not engaged in music.

Sociodemographic data and musical backgrounds of all cases will be recorded. In accordance with the objectives, erm Upper Extremity Hypermobility Assessment Questionnaire "was used for hypermobility, pulmonary function test, respiratory and oral pressure measurement and respiratory muscle strength. The George Respiratory Questionnaire (SGRQ) will be used to assess the quality of life associated with respiration and the risk of asthma with the ile European Respiratory Health Survey, Phase 1 "questionnaire.We believe that the effects of hypermobility on pulmonary functions in healthy individuals will be clarified if this study takes place.

Eligibility Criteria:
Inclusion Criteria for Musicians

Be between 18-35 years Playing wind instruments for at least one year For the hypermobile subgroup; Obtaining ≥7 / 12 points from the Upper Extremity Hypermobility Assessment Questionnaire

Inclusion Criteria for Healthy Individuals Not Engaged in Music

Be between 18-35 years No diagnosed health problems For the hypermobile subgroup; Obtaining ≥7 / 12 points from the Upper Extremity Hypermobility Assessment Questionnaire

Exclusion Criteria for Musicians

Having a specific respiratory problem diagnosed Symptoms of nerve impingement in upper extremity Smoking

Exclusion Criteria for Healthy Individuals Not Engaged in Music

Symptoms of nerve impingement in upper extremity Smoking
Comparative Efficacy of Laser, Extracorporeal Shockwave Therapy and Exercise Therapy on Plantar Fasciitis Outcomes

This study aims to evaluate the effectiveness of exercise combined with ESWT (Extracorporeal Shockwave Therapy), exercise combined with MLS (Multiwave Locked System) laser therapy, and exercise alone in female patients diagnosed with unilateral plantar fasciitis, using Visual Analog Scale (VAS), Heel Tenderness Index (HTI), Foot and Ankle Outcome Score (FAOS), Foot Function Index (FFI) and fall risk, as clinical parameters to assess any differences in effectiveness levels among these treatments.

Plantar fasciitis (PF) is a prevalent condition characterized by the degeneration of the plantar fascia, a band of connective tissue that originates from the calcaneus to the proximal phalanges and the skin of the foot's anterior part. Despite common misconceptions, plantar fasciitis is not primarily an inflammatory process but results from repetitive microtears leading to a secondary inflammatory reaction of the plantar fascia.

Despite the condition's self-limiting nature, with 70% to 80% of patients experiencing symptom relief through conservative treatment alone, a combination of treatments is often necessary for many. Conservative interventions include rest, cold application, stretching and strengthening exercises, orthotic devices, lifestyle modifications, weight loss, and night splints. Additionally, non-invasive physical therapy modalities such as Extracorporeal Shock Wave Therapy (ESWT), laser, and ultrasound have shown to be cost-effective and accessible treatment options. Invasive treatments, including injections and surgery, are considered for resistant cases

Previous studies have examined the effectiveness of ESWT, Low level laser therapy, High intensity laser therapy, and exercise treatments in patients with PF, demonstrating their efficacy. Although there are studies investigating the effectiveness of MLS laser therapy on various musculoskeletal pathologies, to our knowledge, there is no study specifically examining its efficacy on PF

Eligibility Criteria:
Inclusion Criteria:

* Age between 18-65 years
* Female gender
* Symptoms persisting for at least 6 weeks
* Unilateral plantar fasciitis
* Consent to participate in the study

Exclusion Criteria:

* Male gender
* Bilateral plantar fasciitis
* Treatment with ESWT, laser or injection therapy for plantar fasciitis in the previous year
* Participation in a physical therapy program for plantar fasciitis in the last six months
* History of systemic inflammatory disease
* History of lower extremity fracture or surgery
* Pregnancy
* History of epilepsy
* Malignancy
* Active infection
* Coagulation disorders
* Severe cardiac disease or history of pacemaker
* History of neuromuscular disease affecting balance parameters
* Regular use of nonsteroidal antiinflammatory drugs
Convolutional Neural Network Model to Detect Coronavirus Disease 2019 (COVID-19) Pneumonia in Chest Radiographs

This study aims to design a Convolutional Neural Network (CNN) and apply an attention model to help differentiate pneumonia due to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pneumonia due to other viruses/bacteria, and normal chest x-ray (CXR) in clinical practice. A bank of digital chest images from a high-complexity health facility in Cali, Colombia, was used.

To differentiate coronavirus disease 2019 (COVID-19) pneumonia from other types of pneumonia, expert radiologists must analyze the chest x-ray (CXR) to identify visual, radiographic patterns associated with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It is challenging because the findings are similar for different types of pneumonia.

Since the manual diagnosis of COVID-19 from CXR is a difficult and time-consuming process, applying deep learning (DL) models to medical image analysis is a current hot research topic. This work will develop a new Convolutional Neural Network (CNN) to detect COVID-19 radiographs. It will use a large dataset of chest radiographs classified into three classes: viral/bacterial pneumonia, COVID-19 pneumonia, and normal images. The study aims to incorporate a new attention module that applies CNNs to the linear projection operation to help differentiate COVID-19 pneumonia from other pneumonia and normal chest radiographs in clinical practice.

Eligibility Criteria:
Inclusion Criteria:

* Chest radiographs from patients without COVID-19 or other pneumonia took before the pandemic start date (January 2020)
* Chest radiographs from patients with COVID-19 confirmed by positive Reverse Transcriptase polymerase chain reaction (RT-PCR) and/or presence of antibodies to COVID-19 and/or positive COVID-19 viral antigen.
* Chest radiographs from patients without COVID-19 confirmed by a negative Reverse Transcriptase polymerase chain reaction (RT-PCR) and other pneumonia diagnoses taken before the pandemic start date (January 2020)

Exclusion Criteria:

* N/A
A Study of BPI-7711 Capsule in Non-small Cell Lung Cancer Patients

A randomized, double-blind, positive controlled phase III study to evaluate the efficacy and safety of BPI-7711 capsule in locally advanced or recurrent/metastatic treatment-naïve non-small cell lung cancer patients with EGFR mutation

This is a Phase III clinical study, which aims to compare the efficacy and safety of BPI-7711 capsule and gefitinib tablet in the treatment of initially-treated patients with locally advanced or recurrent metastatic with EGFR mutation.

Eligibility Criteria:
Inclusion Criteria:

* Histologically or cytologically confirmed non-small cell lung cancer.
* The ECOG score of performance status is 0-1.
* Locally advanced or recurrent metastatic NSCLC that has never received systemic treatment.
* According to RECIST1.1 criteria, there is at least 1 measurable lesion that has not been previously irradiated.
* Prior to enrollment, a central laboratory testing report has confirmed that the tumor has one of two common EGFR mutations positive that are sensitive to EGFR-TKI therapy, accompanied with or not accompanied with other EGFR mutation, with the exception of exon 20 insertion.

Exclusion Criteria:

* Previously received systemic treatment for locally advanced or recurrent metastatic cancer.
* Primary T790M mutation-positive patient.
* Previous interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonia requiring hormonal therapy, or any clinically proven active interstitial lung disease.
* Known active infections such as hepatitis B, hepatitis C, and human immunodeficiency virus.
* Local radiation therapy is carried out within 1 week; more than 30% bone marrow radiation therapy or extensive radiation therapy is performed within 4 weeks.
* ≤ 4 weeks from major surgery or ≤ 2 weeks from minor surgery.
Prevalence of CVC-associated Sepsis and Use of Blood Cultures in Berlin - Brandenburg

Structured web-based survey in selected hospitals with intensive care units in Berlin- Brandenburg to collect data on the overall number of blood cultures (used) and the prevalence of (positive blood cultures in patients with) CVC - associated sepsis.

The use of CVC represents one of the major risk factors for sepsis, a highly prevalent disease in ICUs. Blood cultures obtained prior to antibiotic administration are part of the SSC Resuscitation Bundle and essential for the outcome of the patient. The CDC criteria to diagnose sepsis do not take into account the overall number of blood cultures obtained and thus, lead to an underestimation of the true incidence of sepsis. Up to now, few data is available on the total number of blood cultures obtained and the relation to the incidence of sepsis in German ICUs.

Eligibility Criteria:
Inclusion Criteria:

* Intensive care units of hospitals in the INABBRA alliance.
* Patients with bacteremia.

Exclusion Criteria:

* Hospitals without intensive care unit.