A Prospective Study of REPeat Ablation In Patients With Recurrent PERSistent Atrial Fibrillation: Pulmonary Vein Isolation vs. Adjunct Posterior Wall Isolation (REPAIR PERS-AF Study)

This study aims to investigate the best strategy for repeat ablation of recurrent persistent atrial fibrillation (AF) after previous persistent AF ablation involving pulmonary vein isolation (PVI) along. Patients with low voltage areas on the posterer wall will be randomized to PVI alone or the posterer wall isoaltion (PWI) in addition to PVI.

This study aims to find a optmal strategy for repeat ablation for recurrent persistent AF after previous persistent AF ablation involving only PVI. PVI is an evident and well documented target for AF ablation. Many other ablation approaches beyond PVI have been reported. PWI is one of the frequently applied methods. However, this appoach has not been studied in randomized clinical trials for recurrent persistent AF after index procedure, thus evidence is demanded for guidance of clinical practice for AF ablation.

The purpose of this study is to clarify this matter by comparing PVI alone strategy with the approach of PVI plus PWI in patients with recurrent persistent AF after index ablation procedure. Since previous clinical studies have shown better outcomes of ablation among patients with normal left atrium (LA) than those with sick LA, ablation strategies in this study will be selected based on voltage mapping of the LA, avoiding unnecessary ablation applications.

The investigators hypothesize that PVI is good enough for patients with normal LA (normal voltage ≥0.5 mV); Among patients with low voltage/scar (voltage \< 0.5 mV), PVI plus PWI is superior to PVI alone.

This study is a prospective, multi-center, open-labeled, partly randomized study. After enrollment, patients will receive a voltage mapping of the LA which is routine for all AF ablation procedures. Based on the mapping results, patients will be stratified into two strata, normal voltage (≥ 0.5 mV) and low voltage (\< 0.5 mV) in the LA posterior wall. Patients with normal voltage in the LA posterior wall will be directly assigned to arm 1 receiving PVI alone treatment (avoid unnecessary ablation of healthy myocardium). Patients with low voltage will be 1:1 randomized in arms 2 and 3 receiving either PVI alone or PVI + PWI treatment.

1. Arm 1: Normal voltage in LA posterior wall - PVI alone
2. Arm 2: Low voltage in LA posterior wall - PVI alone
3. Arm 3: Low voltage in LA posterior wall - PVI + PWI

Three Norwegian University Hospitals, including Haukeland University Hospital, Bergen, St. Olavs Hospital, Trondheim, and University Hospital of North Norway, Tromsø, will participate in this study. The study is expected to last 3 years, 24 months for enrollment and each patient will be followed for a period of 12 months.

In order to minimize bias, subjects will be randomized next to the LA mapping. Patients will be analyzed according to their initial randomization, that is intention-to-treat, even if they never start the treatment, or discontinue, or cross over the group.

Patents will be followed in out-patient clinic at 3, 6 and 12 months after the treatment.

Eligibility Criteria:
Inclusion Criteria:

* Symptomatic patients with persistent AF and indication for repeat ablation
* procedure.
* Patients with recurrent persistent AF (with a duration \<3 year, at least one episode longer than 7 days during the last 6 months and have been electrically cardioverted at least once during the last 12 months) after previous catheter ablation.
* Patients with up to two previous catheter ablations for AF are included if the procedures only involved PVI. Previous PVI procedure(s) with both cryoablation and radiofrequency ablation are accepted.
* Patients have taken at least one antiarrhythmic drug.
* Patients are willing to participate in the study and sign the patient information form.
* Age: 18-80 years old.
* Patients must be on continuous anticoagulation with warfarin (INR 2-3) or direct oral anticoagulant for \>4 weeks prior to the ablation.

Exclusion Criteria:

* Patients with \>2 ablation procedures in the LA for AF or atrial flutter
* Previous ablation procedures for AF involving ablation strategies beyond PVI
* Duration of persistent AF \>3 years
* Presence of atrial flutter or atrial tachycardia
* Presence of an intracavitary thrombus
* Uncontrolled heart failure
* Severe valvular disease
* LA diameter \> 60 mm
* Structural heart disease involving more than moderate valvular stenosis and/or
* Insufficiencies
* Rheumatic heart disease
* Cardiac surgery for valvopathy or for congenital heart disease
* Patients with contraindications to systemic anticoagulation
* Severe renal dysfunction
* Patients who are or may potentially be pregnant.
* Patient not able to be followed up.