cyrilzakka/clinical-trials huggingface dataset:
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe

Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric in-hospital surgical procedure under general or regional anaesthesia during a continued 7-day period of recruitment.

Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric in-hospital surgical procedure under general or regional anaesthesia during a continued 7-day period of recruitment.

Participating centres throughout Europe will contribute routine clinical data describing all eligible patients who undergo surgery during a continuous week (7-days) at convenience of every department within a period of two months from May 1st to July 1st 2011. A questionnaire of around 50 items will be filled during the pre, intra and postoperative periods. The follow-up will end at discharge. The aim of the PERISCOPE study is to validate a simple score to predict postoperative pulmonary complications(PPCs). This score has recently been published in Anesthesiology and you can access linking to: http://journals.lww.com/anesthesiology/Fulltext/2010/12000/Prediction_of_Postoperative_Pulmonary.20.aspx

TIMEFRAME Participants will be followed for the duration of in-hospital stay, an expected average of maximum 5 weeks.

Eligibility Criteria:
Inclusion Criteria:

Patients undergoing a non-obstetric in-hospital surgical procedure, elective or emergent, under general anaesthesia (alone or in combination with regional/neuraxial anaesthesia), neuraxial anaesthesia or plexus block (with and without sedation).

Exclusion Criteria:

1. age \<18 years
2. obstetric procedures or any procedure during pregnancy
3. regional anaesthesia alone, except to neuroaxial and plexus anaesthesia
4. procedures outside the operating room
5. procedures related to a previous postoperative complication
6. transplantation
7. patients with preoperatively intubated trachea
8. outpatient procedures, defined as those requiring less than one day's stay for a patient alive at discharge.
The Accuracy of Brain Biological Electrical Impedance Tomography Screen for Supratentorial Tumors

Compared with MRI or CT, brain biological electrical impedance tomography were performed on patients with supratentorial tumors and healthy people . The AUC (area under the curve) of ROC, which is associated with the increased maximum and the difference between left and right equilibrium of impedance value, is calculated. The specificity of brain biological electrical impedance tomography in screening supratentorial tumors are evaluated.

To compare the changes of parameters detected by brain biological electrical impedance tomography, the enrolled brain tumor patients with cerebral edema were paired with themselves and intravenous infusion of mannitol so that the sensitivity of this device in monitoring cerebral edema can be evaluated.

Compared with MRI or CT, brain biological electrical impedance tomography were performed on patients with supratentorial tumors and healthy people . The AUC (area under the curve) of ROC, which is associated with the increased maximum and the difference between left and right equilibrium of impedance value, is calculated. The specificity of brain biological electrical impedance tomography in screening supratentorial tumors are evaluated.

To compare the changes of parameters detected by brain biological electrical impedance tomography, the enrolled brain tumor patients with cerebral edema were paired with themselves and intravenous infusion of mannitol so that the sensitivity of this device in monitoring cerebral edema can be evaluated.

Eligibility Criteria:
Inclusion Criteria:

1. 18 ≤70 years old, male or female;
2. Preoperative patients who had been diagnosed with supratentorial tumors by MRI/CT or other conventional methods or healthy people (23 cases each);
3. The longest diameter of the brain tumor is ≥3 cm;
4. Informed Consent Has been signed

Exclusion Criteria:

1. Severe systemic compound injury or hemorrhagic shock;
2. Epilepsy, poisoning symptoms;
3. In critical condition;
4. Patients with brain wounds or acute inflammation;
5. Lactation and pregnant women;
6. Those who have no informed consent ability or cannot sign by themselves;
7. The investigator considers it inappropriate for the patient to participate in this clinical trial
Comparison Between 2% Lidocaine Gel and 5% Tetracaine Eye Drop as Topical Anesthesia in Phacoemulsification

This study aimed to compare the efficacy between 2% lidocaine gel vs 0.5% tetracaine eye drop as topical anesthesia in phacoemulsification

Approval from Ethical Committee of Faculty of Medicine Universitas Indonesia was acquired prior conducting the study. Subjects were given informed consent before enrolling the study and randomized into two groups (Lidocaine gel and tetracaine eye drop group). Lidocaine group received 2% lidocaine gel in 1 ml syringe, applied to the eye. Tetracaine group received 0.5% tetracaine eye drop. Topical anesthesia was given 5 minutes before phacoemulsification. Five minutes after phacoemulsification finished, visual analog score (VAS) and subjects and surgeon's satisfaction were assessed. Every additional topical anesthesia needed was recorded.

Eligibility Criteria:
Inclusion Criteria:

* patients aged more than 40 years old who were planned to undergo elective phacoemulsification with intraocular lens implantation at operating room. The surgery was operated by an experienced ophthalmologist. Subjects had been explained about the study, and agreed to enroll and have signed the informed consent form.

Exclusion Criteria:

* Subjects with history of allergy to topical anesthesia (2% lidocaine gel and 0.5% tetracaine eye drop), subjects who used another method of intraoperative anesthesia other than topical anesthesia, subjects with history of phacoemulsification before, subjects with difficulty in communication, dementia, and anxiety.

Dropout Criteria:

* Phacoemulsifications duration more than 30 minutes, and subjects who resigned from the study before the study ended
Acute Assessment of a Micro Multipolar Lead for Enhanced Cardiac Resynchronisation Therapy

Pilot study to evaluate the performance of a lead below 2 French with specific distal shape to deliver efficient LV pacing


Eligibility Criteria:
Inclusion Criteria:

* Male or female patient aged ≥18 years old.
* Patient presenting a CRT-P or CRT-D indication according to the latest ESC guidelines .
* Primary implant of a CRT device (including upgrade from a single or dual-chamber pacemaker or ICD).
* Signed and dated informed consent.
* Patient affiliated with, or beneficiary of a social security category.

Exclusion Criteria:

* Class IV of NYHA (ambulatory or not).
* Allergy to contrast media used for imaging during cardiac catheterization.
* Severe Renal Failure (clearance of creatinine \< 30ml/mn/m²).
* Previous failure catheterization of the coronary sinus, or previous failure of left ventricular lead implantation.
* Already included in another clinical study involving intra-cardiac active implantable device, or participation to any other clinical trial in the last 2 weeks.
* Person deprived of liberty by administrative or judicial decision or placed under judicial protection (guardianship or supervision).
* Known pregnancy, breastfeeding women or in childbearing age without an adequate contraceptive method (failure rate \< 1%).
Albanian Berg Balance Scale

Cross-cultural adaptation, validity and Reliability of Berg Balance Scale in Albanian population

The cross-cultural adaptation will be carried out in accordance with the internationally recommended methodology, following the guidelines: translation, back-translation; dissemination of questionnaires and data collection and analysis.

Eligibility Criteria:
Inclusion Criteria:

* Postural pain
* muscular contractions

Exclusion Criteria:

* mixed fractures
* trauma
* luxation
* tumor
Primary Metastatic Renal Cell Carcinoma Treated With Immunecheckpoint Inhibitors and Cytoreductive Nephrectomy

The benefit of deferred Cytoreductive Nephrectomy (CN) has to be re-assessed in the context of IO +IO and IO + TKI systemic treatment. Given the benefit of CN in the setting of first generation immunotherapy, it is conceivable that both trials underestimated the benefit of CN, in absence of immunotherapy.

In past years, much research has been done into the beneficial effects of cytoreductive nephrectomy in patients with metastatic renal cancer receiving systemic therapy with positive results. In the meantime systhemic therapy, and in particular immunotherapy, have changed. Patients with metastatic renal cancer are increasingly treated with immunocheckpoint inhibitors, but the effect of adding cytoreductive nephrectomy in this group of patients has not yet been investigated. The aim of this study is to investigate whether performing a cytoreductive nephrectomy has a beneficial effect on overall survival in patients with metastatic renal cancer receiving systemic therapy using immunocheckpoint inhibitors.

A randomized controlled trial. All eligible patients have already been enrolled in the PRO-RCC registry, a registry that collects prospective observational data, and have also given consent to be included in other studies as a control cohort. This design is called a TWiC (trial within cohort). After randomization, patients who are randomized into the therapy arm will receive a patient information via their treating physician. Upon participation, an informed consent will be signed and the patient will be scheduled for surgery.

Eligibility Criteria:
Inclusion Criteria:

1. Male or female patients age ≥ 18 years
2. Signed and written informed consent Note: Written and signed informed consent will be obtained before any study procedures, including study-specific-screening procedures, has been performed.
3. Informed consent obtained for being offered future experimental interventions within the PRO-RCC project.
4. Histologically confirmed diagnosis of metastatic clear cell, papillary or chromophobe renal cell carcinoma of intermediate to poor risk, including sarcomatoid features, with
5. World Health Organization (WHO) performance status of 0-1.
6. Surgical candidates based on surgeon and anesthetist assessment
7. Treatment with an IO combination (IO+IO or IO+TKI) as standard of care for metastatic RCC
8. Absence of progression at metastatic sites at time of identification (6month after start of systemic first line treatment). 9) Primary tumor in situ 10) Participation in the PRO-RCC prospective cohort.

Exclusion Criteria:

NA
Collective Motivational Interviewing (CMI) for Adolescents With Internet Gaming Disorder

The present study examines the efficacy of CMI in reducing adolescent IGD symptoms and enhancing social support given by CSOs among adolescents with high risk of IGD (probable IGD cases screened positive by validated tools). It is hypothesized that the intervention group (with CMI plus IGD education materials for both the clients and his/her selected CSO) would show more improvements in reduction in the severity of IGD, motivation to change maladaptive gaming behaviour, craving on gaming, and social support obtained from CSOs than to the control group (only educational materials for both the client and the CSOs).

This study adopts a randomized controlled efficacy study with an open-label parallel-group design. The trial will be registered by the WHO's International Clinical Trials Registry Platform once the project is approved. Research participants will be recruited from the primary and secondary schools, and youth social services. After completing the screening process, research participants who are confirmed to fit the inclusion criteria will be randomly assigned to the intervention group with CMI intervention plus IGD education materials to both adolescents with IGD and their CSO or the control group with IGD education materials alone. The present study sets four-time points to track the change in the between-group difference of the primary and secondary outcomes from the baseline (T0) to post-intervention (T1), 3-month follow-up (T2), and 6-month follow-up (T3).

Eligibility Criteria:
Inclusion Criteria for Adolescents:

* Aged between 10-16
* Probable IGD condition screened by the Internet Gaming Disorder Scale-Short-Form (IGDS9-SF) reaching the cut-off value at 21, those at high risk of having IGD but no IGD cases with clinical diagnosis, although the symptoms measured by IGDS9-SF are equivalent to DSM-5 IGD criteria)
* Hong Kong ID card holder
* Chinese speaking
* Student identity
* Possessing an electronic mobile device or computer
* Willingness to participate in the intervention/control group and complete four surveys (baseline, post-intervention, 3-month follow-up, and 6-month follow-up)
* Can nominate a CSO (e.g., parents) \[client's autonomy is a critical factor to facilitate motivation posited by the self-determination theory (Ryan \& Deci, 2020) (9) to obtain informed consent and parental consent

Inclusion Criteria for CSO:

* Aged greater than 18 years
* Having a close relationship with the adolescent with probable IGD (as rated by participants being generally supportive of the participants)
* Being willing to participate in the present study and provide informed consent

Exclusion Criteria for Adolescents:

* Participants who have psychiatric problems such as psychosis, significant cognitive impairment and/or receiving active and structured psychotherapy about IGD elsewhere will be excluded (Nielsen et al., 2021).

Exclusion Criteria for CSO:

* Participants who have psychosis, aggressive or suicidal behavior
* Having life-threatening medical conditions
Collaborative Healthcare Professionals Approach in Monitoring of Patient Centered Outcomes Through Pathways

The aim of this study is to determine if by providing a collaborative, integrated pathway-based healthcare compared to the usual healthcare, whether or not this would be superior in reducing the length of hospital stay across five high frequency /high risk medical diagnoses: Acute Venous Thromboembolism, Acute Kidney Injury, Community Acquired Pneumonia, Adult Left Ventricular Heart Failure, and Asthma.

This study is a pragmatic randomized controlled trial. To date, there is a scarcity of randomized controlled trials looking at pathway-based, patient-centered healthcare versus usual care in several high-risk or high volume diagnoses that account for the vast majority of hospitalizations in medical settings.

In this study, the pathway care intervention is a collaborative effort that involves healthcare professionals from multiple departments, including pharmacists, health educators, nurses, social workers, nutritionists, and quality management.

For patients allocated to the usual care, these healthcare professionals will deliver standardized care when consulted. For pathway care patients, this collaborative healthcare will be default.

Eligibility Criteria:
1. Inclusion Criteria (Overall Criteria):

   * One principle diagnosis
   * Hemodynamic Stability
2. Inclusion Criteria (Specific to each Diagnosis):

   Acute Venous Thromboembolism:
   * New onset / in-patient

   Acute Kidney Injury:
   * Patients with increased serum creatinine of more than 50% from baseline

   Community Acquired Pneumonia:
   * Age limit

   Adult Left Ventricular Heart Failure:
   * Age limit

   Asthma
   * Acute exacerbation of Asthma
3. Exclusion Criteria (Overall Criteria):

   * Intensive Care Unit (ICU) patients
   * Pregnancy
4. Exclusion Criteria (Specific to each Diagnosis):

Acute Venous Thromboembolism:

* Hemodynamic instability (Systolic Blood Pressure (SBP) less than 90 mmHg or massive Pulmonary Embolism (PE)
* PE patients with an sPESI Score ≥ 1

Acute Kidney Injury:

* Critical care patients (ICU, Coronary Care Unit, burn units)
* Stage 4 and 5 chronic kidney diseases
* Kidney allograft recipients
* Obstructive uropathy
* Glomerulonephritis
* Interstitial nephritis

Community Acquired Pneumonia:

* Intensive Care Unit (ICU) patients
* Pregnancy

Adult Left Ventricular Heart Failure:

* All non-cardiogenic pulmonary edema
* Patients requiring Inotropic agents

Asthma

* Patients with Chronic Obstructive Pulmonary Disease (COPD) and Bronchiectasis
* Severe Asthma (Peak Expiratory Flow Rate (PEFR) less than 40 percent)
Chart Review: Central Motor Conduction Time in Neurological Disorders

Background:

TMS stands for transcranial magnetic stimulation. It is a non-invasive way to stimulate the brain. It helps researchers study the nervous system. TMS can assess central motor conduction time (CMCT). That can be used to diagnose some diseases. It can also show how well treatments are working. Researchers want to study the records of people who have already had TMS. They want to see how it relates to the results of diagnostic studies.

Objectives:

To study the results of transcranial magnetic stimulation in certain neurological disorders. To create a descriptive analysis of the results.

Eligibility:

Records that are already in the NINDS database

Design:

The study will not enroll any participants.

Researchers will search the database for certain terms. These include TMS, CMTC, and motor evoked potentials. This will identify records of people who had TMS for diagnosis.

Using data from the records, researchers will calculate CMCT. They will note other data that relate to CMCT.

Researchers will analyze their findings. They will write a review article.

Personal data will be removed from all the records before the findings are analyzed.

Objective- To retrospectively study the results of transcranial magnetic stimulation (TMS) in various neurological disorders and create a descriptive analysis of the results.

Study population- Existing records of patients within the NINDS database who have had TMS performed to measure central motor conduction time (CMCT).

Design-

* Retrospective descriptive analysis.
* The NINDS EMG Database will be queried using terms such as TMS, CMCT, and MEP (motor evoked potentials) to identify EMG reports on patients who underwent TMS for diagnosis
* Within these reports peripheral motor conduction time (PMCT), the cortical motor evoked potential (MEP) latency and amplitude will be used to calculate CMCT, clinical patient factors pertinent to estimation of CMCT as well clinically significant physical exam findings will be recorded as well.
* Clinical diagnoses and neurological exams will be extracted from medical records
* Patient identifiers will be de-linked after compiling data from medical records

Outcome measures

- Results of CMCT using TMS in different diagnoses will be summarized for different neurologic disorders and correlated to clinical exam measures documented in previous records

Eligibility Criteria:
* INCLUSION CRITERIA:

  1. Patients who were seen in the NINDS EMG section for diagnostic TMS studies
  2. Patients tested between 1998 and 2017
  3. Greater than or equal to age 18.
Clinical Study of the Direct Pulp Capping in Primary Teeth

Research content: select the patients with accidental pulp exposure or decayed pulp exposure in the pediatric dentistry department of The Affiliated Stomatology Hospital of Zhejiang University School of Medicine from February 2022 to October 2022.

1. Strictly implement the case selection criteria to reduce the deviation. 2. Conduct uniform training and assessment for doctors. 3. Record in detail: the age, gender, tooth position, cavity type, x-Ray examination, size and reason of pulp exposure, time of hemostasis, filling material, signs and symptoms of initial consultation and follow-up, etc. 4. Analyze the clinical data to study the success rate of direct pulp capping of primary teeth; analyze the influence of various factors to study how to improve the success rate of direct pulp capping of primary teeth.


Eligibility Criteria:
Inclusion Criteria:

* No irreversible signs or symptoms of pulpitis in the affected tooth.
* Mechanical pulp exposure caused by cavity preparation or trauma, or pulp exposure after decayed tissue removal, with healthy dentin around the pulp exposure.
* The size of the exposed pulp\<1 mm.
* The morphology of pulp tissue at the pulp exposure is normal, and the bleeding should be able to be controlled within 5 minutes.
* X-ray showed that there was no abnormal resorption or fracture of the root and no lesions around the root.

Exclusion Criteria:

* The child is unable to cooperate with the treatment.
* Pulp exposure \> 1 mm.
* Irreversible signs or symptoms of pulpitis in the affected tooth.
* Abnormal morphology of the pulp tissue at the pulp exposure, much bleeding and inability to stop bleeding.
* X-ray shows: abnormal resorption or fracture of the tooth root and lesions around the root.
* The parents or the child refused to participate in the experiment.
Randomized Controlled Trial of Laparoscopic Gastric Bypass Plus Omentectomy Versus Laparoscopic Gastric Bypass Alone in Improving Diabetic Indices

To see if removing the omentum in addition to a gastric bypass improves diabetes is better than just a gastric bypass.


Eligibility Criteria:
Inclusion Criteria:

* undergoing laparoscopic gastric bypass, \>18 yo, understands english

Exclusion Criteria:

* previous lower pelvic surgery, self-pay patients, previous weight loss surgery,
The Open Lung Approach During One Lung Ventilation in Thoracic Surgery

* Question: Ventilatory strategy to counterbalance the effect of one lung ventilation during thoracic surgery.
* Findings: the open lung approach improved oxygenation and lung compliance, reducing respiratory system driving pressure and transpulmonary driving pressure.
* Meaning: patients undergoing thoracic surgery during one lung ventilation may benefit of an open lung approach strategy to avoid ventilator lung injury.

Background: During thoracic surgery in lateral decubitus, one lung ventilation (OLV) may impair respiratory mechanics and gas exchange. The investigators tested a strategy based on an open lung approach (OLA) consisting in lung recruitment immediately followed by a decremental positive-end expiratory pressure (PEEP) titration to the best respiratory system compliance (CRS) and separately quantified the elastic properties of the lung and the chest wall. The investigators hypothesis was that this approach would improve gas exchange and increase lung compliance (CL).

Methods: In thirteen patients undergoing upper left lobectomy the investigators studied lung and chest wall mechanics, transpulmonary pressure (PL), respiratory system and transpulmonary driving pressure (ΔPRS and ΔPL), gas exchange and hemodynamics at two time-points (a) during OLV at zero end-expiratory pressure (OLVpre-OLA) and (b) after the application of the open-lung strategy (OLVpost-OLA).

Eligibility Criteria:
Inclusion Criteria:

* age \> 18 years,
* surgery and OLV lasting ≥ 60 min

Exclusion Criteria:

* lung reduction surgery, pneumonectomy, patients with severe COPD with preoperative forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio, expressed as a percentage (FEV1/FVC%) \<60%, presence of large bullae, pleural diseases and/or acute or chronic uncompensated cardiac disease