cyrilzakka/clinical-trials huggingface dataset:
Acute Effects of Static Stretching Intensity and Duration on Muscle Viscoelastic Properties and Proprioception

The purpose of this study is to compare the acute effects of different duration and intensity of static stretching exercises on the viscoelastic properties of the hamstring muscle and the knee proprioception.

Traditionally stretching exercises have been used by health professionals as a means of preventing injuries by increasing performance and increasing joint flexibility. Kubo et al. suggest that the potential mechanism of decreased risk of injury with increased flexibility is a change in the viscoelastic properties of the muscle-tendon unit. Muscle fibers and tendons contain proprioceptors. These receptors provide information about joint angle, muscle length and muscle tension. There are two stretch-related proprioceptors that transmit information to the central nervous system about muscle tension. These receptors are muscle spindles (respond to changes in the length) and golgi tendon organs (respond to changes in the tension). For this reason, interactions between muscle tension, muscle-tendon unit, viscoelasticity and proprioceptive tissue (muscle spindles and golgi tendon organ); it becomes important when you think about how stretching exercises affect proprioception, flexibility and increase or decrease of joint range of motion. In the literature, four stretching parameters have been defined as important to influence the potential for increasing or decreasing the flexibility of a joint: intensity, duration, frequency and stretching position. The focus of this study we plan on is the intensity and duration of stretching.

Exercise warming exercises before sportive activity and cooling exercises afterwards are widely suggested and applied. Determining the relationship between stretch severity and duration and viscoelastic properties and proprioception will contribute to the effective creation of training programs.

Eligibility Criteria:
Inclusion Criteria:

* Being in the 18-45 age range.
* Volunteer to participate in the study.

Exclusion Criteria:

* Having had previous lower extremity operations.
* Having an orthopedic, neurological and rheumatologic disease of the lower extremities.
* Having open wound in the application area.
* Having had soft tissue injury in the last 6 weeks in the application area.
Effects of Fetal Positioning During Venipuncture

The study was aimed to examine the effects of fetal positioning during venipuncture on the neonates' pain score and physiological parameters (heart rate, blood-oxygen saturation, body temperature, crying duration) in neonatal intensive care unit (NICU).

This randomized controlled clinical trial was conducted between 10.2021-07.2022 with 60 preterm neonates, aged 26-32 week of gestation. Neonates were divided into intervention group (n=30) and control group (n=30) according to the randomization method. The neonates in the intervention group were put into fetal positioning at least 10 minutes before the procedure, and then venipuncture was performed. The fetal positioning was maintained throughout the procedure and the patient was kept in the fetal position for at least five more minutes after the procedure. Changes in the neonates' pain score and crying duration as well as heart rate, blood temperature, blood-oxygen saturation at three time points: before the procedure, immediately after needle insertion, five minutes after needle removal. Data was collected using the sociodemographic form, neonatal observation form and Neonatal Pain, Agitation and Sedation Scale (N-PASS). The collected data were analyzed using the SPSS 15 software.

The main questions it aims to answer:

1. Does fetal positioning have an effect on pain score of premature neonates?
2. Does fetal positioning have an effect on heart rate of preterm neonates?
3. Does fetal positioning have an effect on oxygen saturation of preterm neonates?
4. Does fetal positioning have an effect on body temperature of the preterm neonates?
5. Does fetal positioning have an effect on the crying duration of preterm neonates?

Neonates who were hypotonic, lethargic, in shock or had seizures, stage 3-4 intracranial hemorrhage and a history of surgery were not included in the study. Additionally, neonates was taken any analgesic and/or sedative in the last 24 hours were excluded from the study.

Eligibility Criteria:
Inclusion Criteria:

* Premature newborns (a) whose parents volunteered to participate in the study, (b) required venipuncture, and (c) were born at 26-32 gestational weeks were included in the study.

Exclusion Criteria:

* Newborns who are hypotonic, lethargic, in shock or having seizures,
* Newborns with a history of stage 3-4 intracranial hemorrhage
* Newborns with a history of surgery
* Newborns whose gestational week is over 37 weeks
* Newborns who have taken any analgesics and/or sedatives in the last 24 hours,
* Newborns who have had any invasive procedure within the last hour
* Newborns whose parents do not volunteer
Clinical Registry Collecting Real World Evidence on Wound Care Treatments

Collect data on various wound/injuries treatments and their related wound healing process, in real life settings. Over a 12-week period per wound treated.

Analyze the safety and efficacy of wound treatments, including advanced biological/synthetic grafts with designations of 361 HCT/Ps or 501(k) FDA clearance and standard of care wound treatments.

This clinical registry is an observational study to collect prospective and retrospective data on subject health, wounds and wound care procedures from medical centers, including skilled nursing facilities, hospitals, outpatient clinics, Home Health and any other medical environment where wounds are treated. Structured data including wound photos are to be collected at the point of care in the subject electronic Case Report Form. The registry will enroll data of up to 5000 wounds in up to 50 wound care locations. The dataset includes all wound/injuries and ulcer types.

Eligibility Criteria:
Inclusion Criteria:

1. Subjects are 18 years of age or older.
2. Subject has an ulcer (Diabetic foot ulcer, Venous stasis ulcer, etc.), injury (trauma, post -surgical, MOHS treatment), Burns injury, and acute/chronic wounds.
3. Subject agrees to the use of his health data, including photos of his wound in analysis and publications.
4. Subject/LAR must be able to read and understand English and/or Spanish.

Exclusion Criteria:

1. Subject/LAR is unable to read and understand English or Spanish.
The Effectiveness of Anti-Gravity Treadmill Training

The primary objective of this study is to compare the effectiveness of standard for our practice postoperative physical therapy (PT) program to a PT program that incorporates lower body positive pressure (LBPP) treadmill training for the patients after lumbar discectomy and fusion surgeries.

A prospective, randomized, parallel group controlled clinical study is proposed. The patients will be divided into the two study groups according to the surgical procedure:

1. patients undergoing one-level microdiscectomy for lumbar herniated disc
2. patients undergoing one-level lumbar fusion for degenerative disc disease without notable spinal stenosis.

Each group will consist of 60 patients (see sample size calculations below) who will be randomized into the two equal groups to undergo:

1. Standard postoperative rehabilitation program
2. Standard postoperative rehabilitation program with addition of lower body positive pressure (LBPP) treadmill training

Eligibility Criteria:
Inclusion Criteria:

* Adults between 18 and 65 years old
* Willing and able to comply with protocol and PT requirements
* Patients with primarily radicular and back pain due to degenerative disc disease requiring one-level discectomy for herniated disc or lumbar fusion between L2 and S1
* Willing and able to sign a study specific informed consent

Exclusion Criteria:

* Require more than one-level surgery
* No previous lumbar surgery
* Any ongoing health condition that would make it difficult to adhere to postoperative PT requirements
* Peri-operative or post-operative complications (infection, pneumonia, nerve injury, dural tear, etc.) that would constraint or delay the ability to participate in postoperative PT
* BMI greater than 40
* Active local or systemic infection
Precision Nutrition and Food Safety for Dietary Prevention of Chronic Disease Study

The associations between food nutrition and safety factors with the risk of chronic diseases are still unclear. This study is conducted in Jinhua, a city with a high prevalence of chronic diseases in China, to assess relations between food nutrition and safety factors and chronic diseases.

Investigations of associations of food nutrition and safety factors with the risk of chronic diseases are limited and studies in China are still lacking. The investigators aim to collect basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors, and so on, to assess the association of food nutrition and safety factors including various food items, dietary fatty acids, and internal biomarkers of food contaminants such as acrylamide and 3-MCPD with various chronic diseases in a Chinese middle-aged and elderly population. We will use multi-omics technology to investigate the causal mechanisms. Results from this study will be valuable for chronic diseases prevention in China.

Eligibility Criteria:
Inclusion Criteria:

* Subject aged ≥45 and ≤74 years old
* Subject has complete data on diet and follow-up time

Exclusion Criteria:

had the major illness that had made personal life disabled
N- Homocysteinylated Huntingtin in Huntington's Disease

Descriptive analysis of N- homocysteinylated Huntingtin in 3 groups of human fibroblasts:

1. presymptomatic HD individuals with UHDRS motor ≤ 5 (Mutated Huntingtin),
2. symptomatic HD individuals with motor UHDRS \> 5 (Mutated Huntingtin)
3. human control cell lines, unmutated Huntingtin

Prospective inclusions of 32 subjects with 24 symptomatic HD patients and 8 presymptomatic HD patients.Rationale: This is a pilot study in humans. Over a period of 2 years, the potential recruitment should make it possible to include 32 patients This number will make it possible to calculate the overall variability of the dosage and to have statistics of position and dispersion in the 2 subgroups identified.

Controls: Eight standardized cell lines from human fibroblasts

Eligibility Criteria:
Inclusion Criteria:

* Patient with the symptomatic or presymptomatic Huntington's disease gene (CAG \>= 36)
* Molecularly confirmed Huntington's disease
* Patient 18 years of age and older
* Person affiliated to or benefiting from a social security assurance

Exclusion Criteria:

* Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1
* Pregnant woman, parturient or nursing mother
* Women of childbearing potential who do not have effective contraception
* Intellectual deterioration preventing the understanding of research
Cyclosporine Dose Adjustment According to Calcineurin Activity After Allogeneic Hematopoietic Stem-cell Transplantation

The purpose of this trial is to assess whether an adaptation of cyclosporine (CsA) dose according to a longitudinal calcineurin (CN) activity monitoring would prevent the onset of graft-versus-host disease (GVHD).

Our previous studies established a correlation between increased calcineurin (CN) activity and the risk of developing severe acute GVHD in allogeneic stem cell transplant recipients receiving immunosuppressive therapy with calcineurin inhibitors.

This proof-of-concept trial is aiming at evaluating CALCIneurin activity as a monitoring biomarker of efficacy of cyCLOsporine - (CALCICLO) - for the prophylaxis of acute GVHD. Our aim is to assess whether a longitudinal monitoring of CN activity would permit to adapt and optimize the dose of CsA that would prevent the onset of severe acute GVHD, yet still maintaining an acceptable tolerability profile.

Eligibility Criteria:
Inclusion Criteria:

* Patients were between the age of 12 and 60 years
* Patients planned to receive an allogeneic HSCT following a myeloablative conditioning regimen

Exclusion Criteria:

* Transplant from a syngeneic donor
* Evidence of refractory disease
* Nonmyeloablative conditioning
* Any participation to a study with a new investigational drug within the previous 3 months
Measurements of Anemia and Physiologic Tissue Response to Blood Transfusions in VLBW Infants Using Quantitative NIRS

The study quantified functional measures of red blood cell mass and oxygen in neonatal tissues using a non-invasive optical technique: near infrared optical spectroscopy . The study will determine the absolute concentrations of deoxygenated and oxygenated hemoglobin and calculate the tissue hemoglobin saturation and total hemoglobin concentration in viv. Near infrared optical spectroscopy technique use to assessing and defining tissue status in the anemic state and the tissue's response to transfusions, as well as in monitoring hemoglobin and hematocrit without pain or loss of blood.

Near infrared optical spectroscopy measurements will be conducted on the muscle, on the upper leg,arm or on the back, abdomen and the head. The actual location will depend upon the neonate position and size. A small soft plastic optical fibers probe will be placed to the select study areas and thhe time of the measurement will not exceed 1 hour.

NIRS measurements of hemoglobin and hemoglobin saturation in tissues before and after red-cell transfusions in VLBW infants will determine the true effect of the transfusions, and develop more substantial guidelines regarding indications for transfusion. The accuracy of conventional (invasive) measurements of Hb and Hct could be comparison with results from the NIRS technique and clinical usefulness of the NIRS technique could be evaluated by comparison with trends in conventionally measured values taking fluid status into account.

Near-infrared light does not ionize biological tissue and poses no significant health risk. Since water absorption is low within this spectral range, local heating of the tissue is also minimal. Burns and heat damage to the neonate are highly unlikely.

Eligibility Criteria:
Inclusion Criteria:

* infants weighing less than 1500 grams at birth
* infants receiving at least one packed red blood cell transfusion

Exclusion Criteria:

* neonates who are too unstable as determined by the clinicians for additional human contact
Human Testing of an Over-the-Counter (OTC) Cream in Children With Eczema

This three week study will be conducted to determine the safety and efficacy of an over-the-counter (OTC) cream in children with mild to moderate atopic dermatitis.

The objective of this trial is to evaluate the efficacy and safety of an OTC colloidal oatmeal skin protectant cream in children with mild to moderate AD in comparison to that of EpiCeram®

Eligibility Criteria:
Inclusion Criteria:

* Children ages 6 mo- 18 years
* Any ethnicity
* Diagnosed with atopic dermatitis (AD) per Hanifin-Rajka criteria
* Mild to moderate atopic dermatitis per Rajka-Langeland severity index
* Willing to use only provided cream and body wash for duration of study

Exclusion Criteria:

* Known sensitivity to investigational products
* Pregnant or breastfeeding
* Severe AD per Rajka-Langeland severity index
* AD requiring class I (super potent) or class II or III (potent) topical steroids
* Requires greater than 2.0 g inhaled or intranasal corticosteroids
* Other skin conditions which may interfere with the scoring of AD
Preoperative Intravenous Omega 3 Fatty Acids Administration in Valvular Surgery Patients

The perioperative administration of n-3 fatty acids has been shown to lead to favorable effects on outcome in patients with severe surgical interventions by lowering the magnitude of inflammatory response and by modulating the immune response. To the investigators' knowledge, no study with preoperative administration of intravenous (IV) omega 3 fatty acids as a part of total parenteral nutrition (TPN) or monotherapy with it to demonstrate its effects on inflammatory and immune response has been conducted. So, this study has been planned to judge the inflammatory response of preoperative monotherapy with IV omega 3 fatty acids in elderly patients undergoing valvular surgery considering the hyperinflammation associated with this type of surgery in elderly patients.


Eligibility Criteria:
Inclusion Criteria:

1. Adult male or female patients undergoing valvular surgeries
2. Age 18-50 years
3. The patients who give written informed consent

Exclusion Criteria:

1. Refusal to participate in the study
2. Allergy to any of the constituents of nutritional products
3. HIV positive patients, patients with primary diagnosis of hypertriglyceridemia, patients on long term steroid therapy and cycloxygenase inhibitors (more than 3 months)
4. Severe cardiac disease, hepatic disorders (total bilirubin \> 1.5 times the upper limit of normal), psychiatric disorders likely to affect compliance, severe hemorrhagic disorders, stroke, embolism
5. Uncontrolled severe renal failure (Serum creatinine \> 2 mg/dL) without dialysis/hemofiltration
6. Pregnant or nursing women
7. Participation in any other clinical trial within the last 2 months
Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients

This study is being done because the investigators would like to learn more about how well the COVID-19 vaccine works in participants with cancer or those who have received a transplant or cellular therapy.

Primary Objective

Assess the immunogenicity to COVID-19 vaccination in patients with cancer and/or transplant and cellular therapy (TCT) recipients.

Secondary Objectives

* Evaluate the antibodies response to COVID-19 vaccination in immunocompromised patients.
* Evaluate the T cell response to COVID-19 vaccination in immunocompromised patients.

Exploratory Objectives

* Assess incidence and severity of COVID-19 infections by 6 months following immunization with a SARS CoV-2 vaccine.
* Assess the durability immune response to COVID-19 vaccination.
* Assess the immunogenicity of COVID-19 vaccination in immunocompetent children and adolescents without cancer and have not undergone transplant or received cellular therapy.

The investigator will collect a blood sample (about 1 teaspoon each time) from the participant when the participant receive the COVID-19 vaccine(s) as well as an additional blood samples 6 months after the last COVID-19 vaccine.

The participant will be on the study for about 6 months after the last vaccine. After the six-month blood sample is collected, the participant will be off study.

Eligibility Criteria:
Inclusion Criteria:

* Patient receiving care at St. Jude Children's Hospital or Le Bonheur Children's Hospital
* Less than 24 years old at the time of enrollment (Day 0)
* Planning to receive a COVID-19 vaccine as part of clinical care
* Patient is one of the following:

  1. Diagnosed with a Hematological Malignancy (Group A), or
  2. Received a hematopoietic cell transplant or cellular therapy (Group B), or
  3. Diagnosed with a solid tumor malignancy (Group C).
  4. Received a solid organ transplant (Group D), or
  5. Does not have cancer and has not received any type of transplant (Group E)
* Willing and able to provide informed consent

Exclusion Criteria:

* Received a COVID-19 vaccine prior to enrollment (Day 0).
The Effect of Itraconazole on BCT197 Exposure in Healthy Male Participants

An Open-label, 2-period, Single-sequence, Crossover Study to Evaluate the Effect of Multiple Oral Dosing of Itraconazole on BCT197 Systemic Exposure in Healthy Male Participants.

This will be an open label study conducted in healthy male participants at a single centre. Each participant will participate in a screening visit and 2 study periods. At the first study period, all participants will receive a single dose of BCT197 and at study period 2, all participants will receive 14 daily doses of itraconazole and a single dose of BCT197.

Eligibility Criteria:
Inclusion Criteria:

* Healthy male participants.
* Non-smokers (including e-cigarettes).
* Body mass index (BMI) ≥ 18 and ≤ 30 kg/m2.
* Willing to use highly effective barrier contraception methods.
* Male participants must not donate sperm during the study.

Exclusion Criteria:

* Any participants with pre-existing active skin disease.
* Laboratory values at screening which are deemed to be clinically significant.
* Participants with abnormal liver function tests.
* 12 Lead ECG with QTcF \>450 msec.
* Allergy to any of BCT197 excipients.
* Known hypersensitivity or intolerance to itraconazole.
* Taking medications known to cause QTc prolongation.
* Positive for human immunodeficiency virus (HIV), hepatitis B or hepatitis C.
* Any clinically significant illness within 30 days prior to study drug administration.
* Participants who, in the opinion of the Investigator, are unsuitable for participation in the study.
Long Term Functional Outcomes of COVID-19 Patients Treated by Rehabilitation Services viaTelehealth

This study seeks to assess the impact of physical and pulmonary rehabilitation on patients who have been diagnosed with COVID-19 in the short and long term in hopes of establishing a best practices protocol for treatment of future patients with this disease.

The novel coronavirus that began in Wuhan, China in late 2019 made an appearance in the United States in January 2020. It is a respiratory disease spreading rapidly from person to person. Recent data shows that fibrosis is seen on the lungs, and possible myocardial damage. Data shows that physical therapy was not highly utilized in recovery for these patients due to high PPE demands, and increased risk of exposure. This study will be using telehealth services to assess and treat these patients so Physical Therapy guidance is provided for movement and returning to prior level of function. Currently there is no data showing the long term effects of the those who were able to utilize Physical Therapy in recovering from COVID-19 This study will be looking at the differences in outcomes of COVID-19 positive subjects who able to complete Physical Therapy Telehealth visits versus those who did not. All groups will be tested at multiple data points for lung capacity, upper and lower extremity strength, and overall endurance to determine the long term functional effects. The control group were diagnosed with COVID-19 and recovered before the Physical and Pulmonary protocol was implemented.

Eligibility Criteria:
Inclusion Criteria:

* \>Age of 18
* Positive COVID-19 diagnosis in the last 6 months

Exclusion Criteria:

* Age of \<18