cyrilzakka/clinical-trials huggingface dataset:
Artificial Intelligence in Healthcare: Advanced Evaluation of Medical Online Content. AI-driven Quality Assessment of YouTube Videos Providing Information on Incontinence After Cancer Surgery.

The aim of the study is to analyse the quality of information that patients and relatives of different types of cancer receive through social networks on the subject of incontinence after cancer surgery.

The primary goal of this study is to meticulously analyze and evaluate the overall quality of information that patients and their relatives obtain through social networks. The specific focus of the investigation lies in exploring the subject of incontinence after cancer surgery, encompassing a diverse range of cancer types. By closely examining the information disseminated across various social platforms, the researchers aim to shed light on the accuracy, reliability, and comprehensiveness of the information available. Ultimately, this study seeks to enhance our understanding of the information landscape surrounding post-cancer surgery incontinence, empowering patients and their relatives to make well-informed decisions regarding their healthcare.

Eligibility Criteria:
Inclusion Criteria:

* Anyone providing information about incontinence after cancer surgery.
* English language

Exclusion Criteria:

* Non-english language
* Duplicated
* Related with advertisements
* Nonrelated to incontinence
Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City Hospitals

Prospective observational study


Eligibility Criteria:
Inclusion Criteria:

* pregnant woman 24 weeks to 28 weeks of pregnancy with PROM

Exclusion Criteria:

* gestational age other than the mentioned before Multiple pregnancy Cerclage Other causes of decreased AF
Observational Study in Parkinson's Disease of the Primary Care Population of Patients Treated With Pramipexole

The primary objective of this study was to describe neurologists' population of patients treated with pramipexole and suffering from Parkinson's disease (so called 'primary care' population).

The secondary objectives were:

* Evaluate the mean dose of pramipexole prescribed under actual conditions of use depending on the severity of the disease.
* Evaluate the reasons for choosing pramipexole as treatment.
* Identify the patient profiles determining the choice of dose of pramipexole prescribed


Eligibility Criteria:
Inclusion Criteria:

* Patients suffering from idiopathic Parkinson's Disease and treated with pramipexole for at least two months, examined in consultation

Exclusion Criteria:

* Patient refusing to take part
* Patient taking part in a clinical trial
Human Circadian Sensitivity to Very Short Light Pulses

The mammalian eye serves both visual and non-image-forming functions. New information about the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light stimuli on human circadian rhythms, melatonin suppression, heart rate, pupillary reflexes, cognitive performance, alertness and sleep. The results of the proposed work can be used to make predictions about the effects of light, to make recommendations involving exposure to or avoidance of light, and to design environmental lighting, resulting in improved health and alertness and decreased errors and accidents.


Eligibility Criteria:
Inclusion Criteria:

* Healthy volunteers

Exclusion Criteria:

* No medications
* No eye disease
* No sleep disorders
* No psychiatric disorders
Effect of Liraglutide on Weight Loss in Patients Who Have Undergone Revisional Bariatric Surgeries.

Our primary objective is to assess the effect of Liraglutide on weight loss in patients who have undergone secondary bariatric surgeries. We set out to assess if Liraglutide is a viable option to augment weight loss in said category.


Eligibility Criteria:
Inclusion Criteria:

* Undergone primary bariatric surgery
* Need secondary bariatric surgery due to either weight regain (regained weight to have BMI \> 35) or medical associated diseases

Exclusion Criteria:

* Prior use of GLP-1 agonist
* Past history of pancreatitis
* Personal or family history of medullary thyroid cancer
* Pregnancy or lactation
* Acute coronary syndrome
* Hepatic or renal dysfunction
* Active malignancy
Observational Study of Golimumab Intravenous Infusion

The purpose of this study is to evaluate the incidence and management of infusion reactions with Golimumab intravenous infusion.

This is a prospective, observational, non-interventional (no treatment given during course of the study) multi-center (when more than one hospital or medical school team work on a medical research study), study that will enroll participants with rheumatoid arthritis (RA) in Canada. Only data available from source documentation will be collected. The participation in this study will not impact on the standard of care of the participant or any benefits to which they are otherwise entitled. All aspects of treatment decisions and clinical management of participants will be in accordance with clinical practice and at the discretion of the health care provider. Participants' safety will be monitored throughout the study.

Eligibility Criteria:
Inclusion Criteria:

* Participants must have a confirmed diagnosis of rheumatoid arthritis
* Participants must have provided a written consent for data collection by signing an informed consent form indicating that he/she understand the purpose and procedures for data collection and are willing to participate in the study
* Participants are golimumab-naive (never have used golimumab both SC and IV formulations)
* Participants are prescribed golimumab intravenous by an appropriate physician as per the Canadian Product Monograph

Exclusion criteria:

* Participant who has been treated with golimumab in the past
* Participant has been diagnosed with psoriatic arthritis or ankylosing spondylitis
* Participant has received an investigational drug (including investigational vaccines) or used an invasive investigational medical device within 30 days before the start of the study or first data collection time point
* Participant is currently enrolled in an interventional study
Development of a Novel Signature Integrating Clinical, Imaging And Epigenetic Information to Tailor Pelvic Nodal Treatment in Prostate Cancer

Radical prostatectomy (RP) represents one treatment option for clinically localized PCa. The most updated guidelines of the European Association of Urology indicate the need to perform ePLND in patients with a LNI risk \>5% according to the Briganti nomogram. It allows for sparing ePLND in two thirds of contemporary surgically treated patients, but many patients still receive an ePLND in the absence of lymph node metastases. This is key, since ePLND is associated with significant risks of complications. Improving our ability to detect LNI in PCa would be key for two main reasons: 1. To administer more timely treatments which in turn improve patient outcomes. 2. To avoid significant overtreatment and spare ePLND-related toxicity. Our hypothesis is that lymphatic spread of PCa cells might be predicted through integration of clinical variables, radiologic and epigenomic information. We aim at developing an accurate predictive model that includes radiological and epigenomic information.


Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with localized prostate cancer (cTanyN0M0) who underwent radical prostatectomy and extended PLND
* All included patients presented one or multiple lesions at the mp-MRI of the prostate, defined as PI-RADS 3 to 5
* At least two biopsy cores were required: i) one positive core from the mp-MRI PI-RADS 3- 5 lesion/s (target lesion), ii) one positive core from the systematic sampling (outside the target lesion)

Exclusion Criteria:

* Unavailable or negative mp-MRI, unavailable or negative target or systematic biopsy, and refute to undergo radical prostatectomy with PLND at the Ospedale San Raffaele
The Primary Objective of This Study Was to Investigate the Effect of Insulin on Myocardial Perfusion and Cardiac Function in Patients Undergoing Cardiac Surgery for CPB Using Transesophageal Echocardiography (TEE) to Detect CSBF

The primary objective of this clinical trial was to investigate the effects of insulin on myocardial blood flow reflected by CSBF which was evaluated by TEE. The second aim was to observe the effect of insulin on cardiac function and markers of myocardial damage.


Eligibility Criteria:
Inclusion criteria included

1. age 55-80 years, ASA grade II-III, regardless of gender,
2. BMI 18.5-28.0 kg/m2,
3. scheduled for elective coronary artery bypass grafting (CABG), valve repair or replacement, or a combination of these procedures with cardiopulmonary bypass.

Exclusion criteria

1. non-first cardiac surgery;
2. emergency cardiac surgery;
3. severe heart failure with preoperative left ventricular ejection fraction \<30%;
4. contraindication to TEE;
5. kidney disease requiring replacement therapy;
6. combined with multi-organ insufficiency;
7. Severe infection requiring continuous antibiotic treatment;
8. use of large doses of hormone or nonsteroidal anti-inflammatory drugs within the last 2 weeks.
9. after the patient entered the operating room, if the first blood glucose exceeded 180 mg/dl, a second test was performed 15 minutes later, and if the average of the two blood glucoses exceeded 180 mg/dl, the patient was excluded as well.

Elimination criteria included

1. unplanned secondary CPB;
2. need for intra-aortic balloon pump technical support during the study period;
3. TEE image acquired with poor quality.
fMRI In Spinal Cord Injury Patient After Rehabilitation

The purpose of this study was to evaluate the potential reorganization in the sensorimotor cortex in spinal cord injury (SCI) patients after Body Weight Supported Treadmill Training (BWSTT) associated with conventional motor rehabilitation. The investigators hypothesized that training with weight bearing associated with conventional motor rehabilitation will be able to reorganize the brain.


Eligibility Criteria:
Inclusion Criteria:

* Patients with ASIA C or D and the ability to cooperate with instructions of the motor task required. The motor task was to perform ankle plantar flexion and toe flexion and fingers and thumbs movement of the both sides; they also had to be able to fulfill the general conditions necessary for an MRI exploration.

Exclusion Criteria:

* Patients with uncontrollable spasticity-induced body movements were excluded from the study.
Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population

The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed. In the interventional approach (Part II), it aims to investigate whether and to what extent advanced vascular ageing (AVA) in older subjects with increased cardiovascular risk can be reversed by regular walking- based high intensity interval training.

In the cross-sectional part the investigators analyze physical fitness, vascular health and further outcomes in a healthy older active, a healthy older sedentary and a obese sedentary group with increased cardiovascular risk. The investigators will analyze large and small artery function, physical fitness and activity as well as inflammatory parameters in these three groups. Here the investigators will investigate the influence of physical activity and inflammatory parameters on the vascular health in different beds.

In the intervention part the older sedentary group with increasing cardiovascular risk (OSR) will be randomized in a control and an intervention group. The intervention group will get a high intensity interval training which is walking based and individual adjusted. The control group will get general lifestyle recommendations. After 12 weeks of training OSR group will be tasted again. The aim of the second part is to assess the effect of high intensity interval training on vascular health and inflammatory parameters.

Eligibility Criteria:
Inclusion Criteria:

* men and women aged 50-79 years
* Active lifestyle: \> 9 MET/week (\> 3hours moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
* Sedentary lifestyle: ≤ 3 MET/week (≤ 1 hour moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
* Sedentary men and women aged 50-79 years with increased cardiovascular risk are allowed to have ≥ one additional cardiovascular risk factor

Exclusion Criteria:

* History of cardiovascular, pulmonary or chronic inflammatory disease
* blood pressure ≥ 140/90 mmHg during 24h monitoring
* current or past smoker (in healthy group)
* macular degeneration or glaucoma
* compromising orthopaedic problems
Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis

combining the non-surgical therapy with a well-tolerated substance that can stimulate protective immune responses like B-glucan, might effectively mount resolution pathways contributing to resolving of the chronic lesion observed in aggressive forms of periodontal disease.

Aim: To investigate the efficacy of β-glucan supplementation to non-surgical periodontal therapy in localized aggressive periodontitis (LAP) patients.

Method: 30 subjects were randomly and equally assigned to receive scaling and root planing; either with placebo pills (Group I) or β-glucan (100 mg/once a day) (Group II), for 40 days. Subjects were clinically monitored on day 0 and day 91. Gingival samples were harvested from hopeless teeth sites to be investigated histologically and immunohistochemically using matrix metalloproteinase (MMP)-1 and 9 antibodies form each patient; at the same time intervals.

Eligibility Criteria:
Inclusion Criteria:

* Except for periodontitis, patients were systemically healthy as evaluated by modified Cornell medical index.
* No more than two teeth other than first molars and incisors, with probing depth (PD) ≥ 5mm, bleeding on probing (BOP), and clinical attachment level (CAL) ≥ 5mm.
* Rapid rate of attachment loss and bone destruction.
* A radiographic examination revealing an evidence of moderate to severe vertical bone loss around permanent incisors and first molar teeth.
* Every patient should have at least 20 teeth excluding third (3rd) molars, and at least an extraction-indicated tooth for a dento-periodontal affection.
* Familial aggregation.

Exclusion Criteria:

* Previous subgingival scaling and root planing, allergy to β-glucan, smoking, former smoking, pregnancy, need of antibiotic coverage for routine dental therapy, antibiotic therapy in the previous 6 months and allergy to chlorhexidine.
The Study of the Natural Way of Development of External Pancreatic Fistulas in Children with Necrotizing Pancreatitis

The external pancreatic fistula (EPF) is characterized by the leakage of pancreatic juice outward through an area of skinor through a drainage tube.

The leakage of pancreatic juice occurs due to the rupture of the pancreatic duct (PD) caused by the destruction of pancreatic tissue. EPF can cause deterioration in the patient's condition due to the leakage of protein-rich pancreatic juice outward, as well as the increased risk of skin irritation and infection.

The treatment of EPF has traditionally been conservative, including the nutritional support in an attempt to reduce pancreatic secretion, or total parenteral nutrition with antisecretory therapy (octreotide). In cases where the conservative therapy has proved to be ineffective, there has been performed the surgical treatment. The cases of successful treatment of EPF by endoscopic transpapillary drainage have been reported in the literature as an effective and minimally invasive therapeutic alternative to the surgery for the treatment of EPF. However, the endoscopic transpapillary drainage is usually ineffective in patients with the complete PD failure. The complete PD failure in the presence of the functional pancreas above the failure results in the disconnected pancreatic duct syndrome.

Sepsis, infection, electrolyte disturbances, malnutrition, and infections are commonly seen in patients with high-output EPF. In addition, there has occasionally been reported the spontaneous closure of low-output EPF. However, there are no data on the natural history of EPF.

The aim of this study is to evaluate the natural clinical history of EPF in children with necrotizing pancreatitis by examining the outcomes and the complications of the conservative treatment.

Eligibility Criteria:
Inclusion Criteria:

* Patient or legal representative consent
* External pancreatic fistula
* Age from 0-18 years
* Moderate severe (MSAP) or severe acute pancreatitis (SAP) according to Atlanta criteria revisited in 2012
* Acute Pancreatitis was defined in case of the presence of at least two of the three criteria according to the classification developed by the INSPPIRE (International Study Group of Pediatric Pancreatitis: In Search for a Cure) group: abdominal pain consistent with the diagnostic hypothesis; serum amylase and/or lipase increased by ≥3 times; imaging results typical of AP: abdominal ultrasound and/or contrast-enhanced CT.

Exclusion Criteria:

* Mild acute pancreatitis
* Chronic pancreatitis
* No consent from patient or legal representative
Adolescents' Health Literacy, Physical Activity and Healthy Eating Self-efficacy Levels

Adolescence is a critical transitional period characterized by rapid and multifaceted changes in physical, psychological, and social dimensions. According to the World Health Organization, adolescence encompasses the age range of 10 to 19 years. Alongside physical changes, this period involves significant developments and transformations in knowledge, skills, and behaviors, driven by the individual's identity formation process. Health behaviors such as nutrition and physical activity play a pivotal role in protecting and promoting adolescent health. However, unhealthy eating habits and insufficient physical activity are highly prevalent among adolescents.

These behaviors are associated with physical problems, including obesity, diabetes, hypertension, cardiovascular diseases, delayed growth and development, and psychological issues such as susceptibility to stress, low self-esteem, and lack of confidence. Consequently, fostering healthy eating and physical activity behaviors in adolescents is essential.

Given that adolescents spend a considerable portion of their time in school, implementing school-based interventions to promote these behaviors represents an effective approach to preventing lifestyle-related health issues in adulthood. The literature indicates that various interventions aimed at improving nutrition and physical activity behaviors in adolescents are generally effective. Nevertheless, sustaining these behaviors in the long term remains a challenge, as studies have shown that increases in knowledge do not always translate into behavioral changes.

One of the most effective strategies for instilling healthy behaviors in adolescents is health education. School-based health education not only facilitates the acquisition of functional health literacy but also strengthens the attitudes, beliefs, and practical skills necessary for adopting and maintaining healthy behaviors. Moreover, health education is a powerful tool for enhancing health literacy components such as accessing, understanding, evaluating, and utilizing accurate health information, enabling adolescents to take responsibility for their health and make informed decisions.

This study aims to contribute to fostering healthy eating and physical activity behaviors in adolescents, supporting their transformation into lifelong habits. Additionally, the findings are expected to guide school health professionals, particularly school nurses, in expanding interventions within the scope of school health services.


Eligibility Criteria:
Inclusion Criteria:

* - Volunteering to participate in the research
* Being allowed to participate in the study by their parents
* No physical or mental disabilities and chronic diseases (diabetes, metabolic syndrome, heart disease, etc.)

Exclusion Criteria:

* - Incomplete completion of research data collection forms
* Declining to participate in the research
* Failure to complete at least 5 health education sessions
A Composite MR Neuroimaging Marker for Alzheimer's Disease

The purpose of this study is to use a functional MRI (fMRI) index to compare the brain activity of healthy volunteers to that of people with mild cognitive impairment (MCI) and Alzheimer's disease. The ultimate goal is to develop an early diagnostic tool for Alzheimer's disease.

The study hypotheses are:

1. The fMRI index will differentiate between Alzheimer's disease, non-Alzheimer's dementia, and healthy volunteers;
2. The fMRI index will distinguish participants with MCI who convert to Alzheimer's disease from those who convert to a non-Alzheimer's dementia and those who remain stable;
3. MCI participants with a lower fMRI index at baseline who convert will progress to Alzheimer's sooner than those with a higher fMRI index, and MCI participants with a faster rate of fMRI index decline who convert will have an earlier onset of Alzheimer's disease.

The onset of Alzheimer's disease is insidious and the boundary between normal aging and Alzheimer's disease is blurred. In order to prevent and treat Alzheimer's disease, the investigators must be able to mark its preclinical stage, before brain damage becomes irreversible. There is a substantial body of research dealing with predictive markers of Alzheimer's disease in individuals with mild cognitive impairment (MCI). Despite these advances, however, researchers have not had enough evidence to recommend specific techniques that mark preclinical Alzheimer's disease. This new functional MRI (fMRI) index may fill this gap.

Participants will have two visits, one for memory testing and neurological examination, and one for an MRI scan. Each visit will take approximately 1½ hours. For volunteers who wish to do so, all study procedures may be completed in a single visit. Participants with MCI will be followed annually.

The investigators are currently enrolling healthy volunteers, as well as individuals with MCI (memory loss that does not significantly affect normal daily activities), Alzheimer's disease, and frontotemporal dementia (includes primary progressive aphasia).

Eligibility Criteria:
Inclusion Criteria:

* 60 years of age or older (50 years of age or older for frontotemporal dementia patients)
* Normal memory, mild cognitive impairment (memory loss that does not significantly affect normal daily activities), or clinical diagnosis of Alzheimer's disease or frontotemporal dementia (includes primary progressive aphasia)
* Right-handed
* General good physical health

Exclusion Criteria:

* History of stroke or neurological disease (other than Alzheimer's disease or frontotemporal dementia)
* Seizures or head injury with loss of consciousness within the last five years
* Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
* Claustrophobia