3D Printed Implant for Management of Gummy Smile Through VISTA Technique

the most important esthetic concern for dental patients is excessive display of gingiva during smiling due to multiple causes e.g. hyperplasia of gingival, skeletal overgrowth of the anterior maxilla, altered passive eruption, maxillary alveolar tooth extrusion, short lip and lip hypermobility therefore accurate diagnosis of these factors is essential before treatment to ensure the most suitable approach is chosen. Maxillary overgrowth may cause sub nasal skeletal depression that lead to retraction of upper lip during smiling, causing gingiva display. The aim of this study is to describe an alternative technique to treat gingival smile with minimally invasive vestibular incision subperiosteal tunnel access (VISTA) to place 3D printed polymethylmethacrylate (PMMA)-based bone cement versus polyether ether ketone (PEEK) for lip repositioning.

A smile plays an important role in determining a person's initial impression and its assessment has become integral to clinical evaluation owing to how appealing a smile could be among people. A gingival smile, gummy smile or high smile line is an aesthetic concern with 10-12% prevalence among dental patients mainly in women and is diagnosed when a patient shows ≥3 mm of free gingiva.

A gummy smile may result from a single cause but is more commonly found to be the result of an interplay of multiple factors and identifying the causative factor is the basis for its treatment. It may be broadly caused by dentoalveolar discrepancies or non-dentoalveolar discrepancies. Dentoalveolar discrepancies include short clinical crowns, altered passive eruption and gingival hypertrophy/hyperplasia. These discrepancies can be improved by restorative and periodontal approaches. Non-dentoalveolar discrepancies include hyperactive upper lip, short, or incompetent upper lip and vertical maxillary excess. Orthognathic surgery, lip repositioning (LRT), orthodontic treatment, and Botox injections are the main treatment modalities typically employed for treating thesis conditions.

LRT, first described by Kostianovsky and Rubinstein in 1976, has shown excellent efficacy in treating gummy smile, showing an average reduction of 2.71 to 3.4 mm at 6 months of follow-up in previous systematic reviews. However, the traditional technique has reported different partial or complete degrees of relapse. Therefore, different modifications have been developed to improve the predictability and stability of the technique and reduce morbidity and complications.

Most modifications reported in the last 5 years aim to provide improved stability of outcome by introducing techniques that eliminate or restrict the function of the muscles responsible for raising the upper lip during smile or that alter/restrict the hypermobility of lip movement. Some of these techniques include the use of adjuvants such as botulinum toxin (BOTOX).

Injecting overactive muscles with measured amount of botulinum toxin results in a reduction of muscle activity, relaxation of the lip muscles and decreasing upward pull on the lip. The improvement achieved is almost immediate but remains only for a period of 3-6 months, before slowly fading. This relatively short duration is the major disadvantage of the technique, that require constant reapplication and the effects of long-term use of Botox have not been adequately researched

Other approaches, such as the incorporation of muscle resection or the introduction of polymethylmethacrylate (PMMA) implants are intended to have a permanent effect. PMMA is a cross-chain polymer material compatible with human tissues, and since World War II it has been utilized in medicine, for cranioplasties in neurosurgeries, secondary to decompressive craniectomy. It is still the most used reconstructive material by many clinicians because it is one of the most available biocompatible alloplastic materials that elicit low foreign body reaction and provide adequate protection to adjacent neural tissues. Its first application in dentistry was for full dentures and it has shown promising results such as good biocompatibility with the oral tissues.

PMMA bone cement can also be used as graft material for extraction sites, furcation lesions, correction of maxillary and mandibular contours and in 2017, Torres et al. published the first study in which PMMA was used for sub nasal depression in cases of vertical maxillary excess. To restore deficient thickness of alveolar bone and perform adequate lip support, PMMA was directly modified and adapted on the bone surface. Another study in 2018 and 2024, Conventional full thickness mucoperiosteal flaps had been used to obtain access to the labial alveolar bone surface, to place and secure the PMMA device with fixation screws.

To overcome intraoperative complication such as incomplete polymerization, exothermic reactions, low physical properties and prolonged operation time, a new approach using 3D print for the use of PMMA cement to decrease lip movement, reposition the upper lip and decrease the gingival exposure. In 2023, de Castro et al., described alternative technique to treat gummy smile with minimally invasive vestibular incision subperiosteal tunnel access (VISTA) and PMMA implants for lip repositioning. Although the published case reports have shown good outcomes for this specific indication, there is a need to better codify the indications for the procedure and to have stronger clinical evidence to support its use.

In addition to PMMA, Polyether ether ketone (PEEK) has become a hot topic for new material research due to its good biocompatibility, excellent fatigue properties, excellent mechanical properties, high toughness, relatively low wear rate, corrosion and aging resistance, ease of processing, and color stability. Additionally. Recently, 3D printing has been used to manufacture PEEK scaffolds and prostheses. This technique can produce more precise and complex end products.

Considering its advantageous physical properties and the low rate of postoperative complications reported in the literature, PEEK is a reliable biomaterial for patient-specific implants in facial recontouring as has been described as part of reconstruction of skull defects and those in the orbital-maxillo-zygomatic district, both in post-traumatic and in post cancer situations. However, fewer reviews have provided a through summary about the recent advances in PEEK for a variety of dental applications.

Future research should focus on the impact of different materials of bone cement grafts whether PMMA or PEEK to manage the gingival smile in facial profile at rest and during smiling, thereby enabling the understanding of some of the possible side effects of this intervention.

Eligibility Criteria:
Inclusion Criteria:

* Patients having excessive gingival display ≥ 4 mm.
* Clinically diagnosed and radiographically confirmed maxillary subnasal depression.
* Good compliance with the plaque control instructions following therapy.
* Availability for follow-up and maintenance program.

Exclusion Criteria:

* Smokers.
* Pregnant and lactating females.
* Patients with insufficient keratinized gingiva.
* Patients who had done any surgical procedure in the same region.
* Patients who had done fixed or removable prostheses in any anterior maxillary teeth.
* patients currently using medications linked to gingival hyperplasia.
* Systemic diseases that could affect the outcome of the therapy (according to the modified Burkett's health history questionnaire).
* Vulnerable groups of patients' e.g. (handicapped patients).