cyrilzakka/clinical-trials huggingface dataset:
Comparison of Short-term Application of Dialysis Catheter With Tunnel-cuffed Catheter Versus Non-ccuffed Catheter: a Multicenter Prospective Cohort Study

Through a multi-center, prospective cohort study, hemodialysis patients with right internal jugular vein catheterization were collected and divided into tunnel-cuffed catheter group and non-cuffed catheter group according to the types of catheterization. The incidence of catheter infection, thrombosis and other complications between the two groups were compared.To clarify the difference of short-term infection rate between tunnel-cuffed catheter and non-cuffed catheter.


Eligibility Criteria:
Inclusion Criteria:

* ① Age ≥18 years; ② Uremia, clinical evaluation needs to start hemodialysis immediately, and the right internal jugular vein catheterization is the vascular access for the subjects. ③ Subjects who underwent right internal jugular vein catheterization on regular hemodialysis due to poor internal fistula function and the recovery time of internal fistula was ≥4 weeks; ④ Patients with AKI who need renal replacement therapy and underwent catheterization in the right internal jugular vein, and the renal replacement time is ≥4 weeks.

Exclusion Criteria:

* ① Subjects with previous history of central venous thrombosis, stenosis, infection, etc. ② The subjects were not dialyzed three times a week; ③ Other subjects with central venous catheterization, including left internal jugular vein, femoral vein and subclavian vein; ④ Those who take immunosuppression for a long time.
Clinicopathological Characteristics and Prognosis Analysis of Stage IB Non-small Cell Lung Cancer

The goal of this observation study is to learn about clinicopathological characteristics and prognostic factors of stage IB NSCLC. The main question it aims to answer is wheather there is relationship between newly proposed clinicopathological features and the prognosis of stage IB NSCLC .The postoperative pathological and follow-up information of participants will be used for subsequent analysis.

A total of 971 NSCLC patients with pathological stage IB resected by surgery (R0) from January 2016 to December 2020 at Zhongshan Hospital of Fudan University were reviewed. The primary endpoint is RFS (recurrence-free survival) and OS (overall survival) is the secondary endpoint. The baseline characteristics of the patients were obtained statistically, and factors affecting the prognosis of patients with stage IB NSCLC were analyzed using survival analysis and Cox proportional hazard models. The characteristics of the patients include pathological type, STAS, GGO, gene mutation, and postoperative adjuvant chemotherapy.

Eligibility Criteria:
Inclusion Criteria:

* It was confirmed by histopathology as primary non-small cell lung cancer, and the pathological type was LUSC or LUAD;
* According to the 8th edition of TNM clinical staging standards, it is determined as IB stage
* No treatment was performed for the primary lesion of lung cancer before surgery;
* No history of other malignant tumors before surgery;
* Detailed clinical and pathological information, complete survival data, and no missing follow-up data.

Exclusion Criteria:

* The postoperative histopathological types include non-scale and non adenocarcinoma, such as lung adenosquamous cell carcinoma, large cell lung cancer, or lung sarcomatoid carcinoma;
* Multiple lesion staging surgery;
* History of merging with other malignant tumors
* Having preoperative treatment;
* Missing follow-up information.
Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis

The purpose of this study is to determine if celiac bloc (with injection of steroid and local anesthetic) is superior to a sham procedure for pain control and quality of life improvement in patient with chronic pancreatitis and abdominal pain.

Chronic pancreatitis is a condition that can lead to very disabling pain symptoms that are difficult to control. The use of morphine is often necessary and also induces a series of secondary symptoms.

In this context, the injection into the celiac plexus block of a local anesthetic has often been proposed as an alternative. This procedure, by interrupting the afferent pain signal of pancreatic origin, aims to reduce pain and improve quality of life at the cost of fewer side effects.

This procedure can be performed transcutaneously using the anatomical landmark or under radiological control. It can also be performed via endosonography (EUS) with better control of the injection site under ultrasound control.

The results of the literature concerning the efficacy of the celiac block in chronic pancreatitis are rather encouraging with reported figures of partial or complete pain control in 39 to 65% of patients \[1-7\].

However, the number of prospective studies concerning this technique performed endoscopically remains low to date. In particular, there are no case control studies. Data is also poor on the impact on quality of life.

The study proposed here will therefore attempt to provide answers to the questions still pending: is the block by EUS superior to a diagnostic EUS without treatment? ; how long does this treatment last? ; does it have an impact on the quality of life of patients? This study and its draft are inspired by a similar recent study conducted in our department on patients with pancreatic neoplasia. The results of the latter are being submitted for publication.

Eligibility Criteria:
Inclusion Criteria:

* abdominal pain compatible with pancreatic ethiology since at least 3 months
* chronic pancreatitis on Computed Tomography (CT), Endoscopic Retrograde Cholangiopancreatography (ERCP) or EUS
* EUS feasible
* inform consent

Exclusion Criteria:

* pregnant women
* allergy to local anesthetic
* acute pancreatitis in the last 2 weeks
* suspicious lesion on pancreatic EUS examination
* celiac bloc in the last 3 months
Antibiotic Usage and Resistance; Knowledge and Practices Before and After Educational Sessions

The inappropriate use of antibiotics by patients not only increases the growth of resistant bacterial strains but also, may lead to adverse side effects that range from gastrointestinal disturbances to fatal anaphylactic shock. To meet the challenges faced by the spread of antibiotics resistance, different approaches have been taken worldwide. One of the approaches which are commonly proposed is to engage instructional and educational campaigns among the health care personnel and the general population about antibiotic resistance and its dangerous consequences.The present study aims at assessing the knowledge, practices of antibiotic uses and resistance before and after educational sessions among second year dental students and a group of patients attending MIU Dental Clinics.

Statement of problem: Dental students' and patients' knowledge about antibiotic uses are essential for overcoming antibiotic resistance. Antibiotic resistance is considered an important global public health problem and is recognized as a major cause of the emerging problem of antimicrobial agent resistance. The inappropriate use of antibiotics by patients not only increases the growth of resistant bacterial strains but also, may lead to adverse side effects that range from gastrointestinal disturbances to fatal anaphylactic shock. To meet the challenges faced by the spread of antibiotics resistance, different approaches have been taken worldwide. One of the approaches which are commonly proposed is to engage instructional and educational campaigns among the health care personnel and the general population about antibiotic resistance and its dangerous consequences.

Aim of the study: The present study aims at assessing the knowledge, practices of antibiotic uses and resistance before and after educational sessions among second year dental students and a group of patients attending MIU Dental Clinics.

Materials and Methods: The study will be conducted on (315) second year dental students through a pre-and post-educational sessions questionnaire. Students will receive training sessions for four hours during their dental public health course given by senior staff members before conducting educational sessions targeting patients attending MIU Dental Clinics. Educational sessions will include verbal and visual tools.

Eligibility Criteria:
Inclusion Criteria:

* Second year dental students at MIU during the Academic Year 2017/2018. Any patient over 18 years old attending the MIU Dental clinics, and agreeing to sign an informed consent to participate in the study

Exclusion Criteria:

* Patients with mental disorders, deaf, and blind patients will be excluded from the study because the educational sessions will include verbal and visual tools.
Investigation of Heart Rate Variability During the Menstrual Cycle

In this study, women will be required to wear a heart rate monitor continuously and collect daily early morning urine samples for the duration of one complete menstrual cycle. This will enable comparisons between data collected from the heart rate monitor and hormone analysis in urine samples to be made.

This pilot study is a prospective observational study of women's heart rate and heart rate variability throughout one complete menstrual cycle. A minimum of 10 volunteers aged 18 years of age or over will be recruited via a variety of methods according to the criteria detailed in section 9. They will be required to wear a heart rate monitor continuously and collect daily early morning urine samples throughout one menstrual cycle.

Urine samples will be returned to SPD on a regular basis for measurement of urinary hormones related to pregnancy and fertility. Data collected via the monitor including heart rate and heart rate variability will be downloaded for comparison.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 years and over
* Regular menstrual cycles

Exclusion Criteria:

* Taking any hormonal medications
* Taking any medications that may affect heart rate
* Known heart condition or use of a pacemaker
* Skin condition where there is sensitivity to wearing a skin monitor
* Currently suffering with anxiety or panic attacks
* Pregnant or breastfeeding
Pilot Study on Digitally Supported Home Exercises for the Management of Unspecific Low Back Pain.

The overall purpose of the study is to investigate effect of Digitally Supported Home Exercises (DSHE) in different groups for which digitally supported interventions could be beneficial. Balance is altered in individuals with low back pain and requires intervention Thus, the investigators will focus on the effect of DSHE to improve postural balance.

The investigators want to investigate whether a digitally supported exercise program can improve the balance of people with non-specific lower back pain. During the exercise program, a computer game at home is controlled with the help of sensors attached to the body. Second aim is to record the daily activities of the participants and compare them with the back pain.

The 120 participants in this study will be divided into four groups (A, B, C and D). In groups A and B 20 patients are included who are in treatment for chronic back pain and receive Medical Training Therapy (MTT). For groups C and D the investigators will invite each 40 participants who have back pain but are not in treatment for their back pain. Only participants in groups A and C receive the digitally supported home exercise program. Who gets the training program is randomized using stratified block randomization.

The balance of all participants is measured four times. Between the 2nd and 3rd measurement the digitally supported exercise program is carried out. Between the 3rd and 4th assessement, participants in group A and C can exercise as much as they wish. The person who carries out the balance tests will not be informed which participant is in which group.

Eligibility Criteria:
Inclusion Criteria Group A and B

* Patients with chronic unspecific low back pain
* Patients of the Medical Training Therapy (MTT)
* Adult male and female participant's (≥18 years)
* Informed consent as documented by signature

Inclusion Criteria Group C and D

* Participant reports unspecific low back pain
* Receiving no therapy nor medical treatment for the last 6 months
* Adult male and female participant's (≥18 years)
* Informed consent as documented by signature

Exclusion criteria All Groups

* Patients with specific causes for low back pain
* Radicular syndrome
* Unable to participate currently in the program due to pain
* Pregnancy
* Medication effecting postural balance
* Uncorrected heavy visual impairment
* Allergy to adhesive tape
* Unable to understand and communicate in German or English
Evaluation of Musicotherapy on Pain During Wound Closure in the Emergency Department

To evaluate the effectiveness of music listening (with a musicotherapy application Music Care) on patients pain associated with care during wound suturing in the Adults emergency unit.

BACKGROUND - Music therapy is known as an effective adjuvant treatment for the management of physical pain and anxiety. It is recognised in various medical fields. Wound suturing in the Emergency Department is a potentially stressful and painful experience for patients.

OBJECTIVE - To evaluate the effectiveness of music listening (with a musicotherapy application Music Care) on patients pain associated with care during wound suturing in the Adults emergency department.

METHODS - Therefore, a prospective, randomised, open-label, multi-centre interventional will be conducted in two Adults Emergency departments of the Reunion Island University hospitals.

Patients over 18 years old admitted to the Adults Emergency Departments with a suturable wound (at least one stitch), able to understand and express themselves will be included.

The primary outcome is the comparison of maximal VAS score between the two groups. Secondary outcomes are the absolute change in heart rate, systolic and diastolic blood pressure, respiratory rate, absolute change in anxiety score, suture duration related to the number of stitch, overall patient and practitioner satisfaction.

The baseline data collection includes patient age and sex, pain and stress VAS and biological parameters (heart rate, blood pressure, respiratory rate) at admission in box and immediately after suturing.

In order to demonstrate a difference of 10mm on VAS with a standard deviation of 20mm, a power of 90% and an alpha risk of 0,05, the number of subjects required is 192.

A multivariate analysis was performed on the association between exposure : music/no music and the judgement criteria. Subgroup analyses are planned for age, gender, additional analgesia used, location, duration of analgesia used, location, duration of suture and number of stitches.

EXPECTED RESULTS - Thanks to music therapy, a decrease of pain and anxiety associated with sutures in the Emergency room is expected, but also an improvement in the working conditions hospital physicians in the emergency room.

Eligibility Criteria:
Inclusion Criteria:

* \> 18 years admitted to ER with suturable wound (at least 1 stitch)
* able to understand and express oneself
* giving free, informed and written consent signed by the participant and the investigator

Exclusion Criteria:

* who has a severe wound with suspected open fracture or requiring surgical exploration in the operating room
* with severe hearing loss or deafness, speech disorders or any acute or chronic condition that compromises listening (at the investigator's discretion), musicogene epilepsy
* no social security cover
* unable to decide for himself or herself (at the discretion of the investigator): confused patient, foreign language not understood by the investigator, severe acute intoxication, patient with severe neurological or psychiatric comorbidity
* under judicial protection
Study of the Reaction of the Brain to Various Stimulations

Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both metabolism (muscle hypertrophy, improvement in oxidative metabolism) and the nervous system (neuroplasticity). Nonetheless, even though there is a consensus on the positive effects of physical exercise (PE) on cerebral plasticity, the physiological mechanisms by which PE affects neuroplasticity, in particular depending on the mode of muscle contraction, are still hypothetical. Moreover, several recent studies have shown that mental learning (ML) by motor imagery improves motor performance, thus making it of interest in a context of rehabilitation, in particular in situations where PE is transient of definitively impossible. Yet, the mechanisms and brain structures involved in motor learning by ML have not been established so far. Finally, on the basis of clinical observations concerning the key role of sensory input in motor function, the hypothesis that increased demand on this input by electrical stimulation (ES) as a means to improve motor function has been proposed. However, the mechanisms by which this type of stimulation could induce neuroplasticity is still to be elucidated.


Eligibility Criteria:
Inclusion Criteria:

* persons who have provided written consent
* healthy subjects
* national health insurance cover
* age 18 to 60 years

Exclusion Criteria:

* personal or family history of epilepsy
* pacemakers or other apparatus likely to interfere with the magnetic field
* history of psychiatric disease
* Persons under guardianship or wards of court
* Pregnant or breast-feeding women
* problem perceived during the neurological examination which could bias the results of the study
Development of Cellular Models for Osteoblast Response Study to Adipocytic Secretions in an Osteoporosis Context.

The recent studies suggest that secretions from medullary adipocytes are involved in the mechanisms of bone loss in osteoporosis (OP) through their actions on neighbouring osteoforming cells, the osteoblasts. The objective of the research is the development of new cellular models representing the aging skeleton to confirm this hypothesis. To this end, osteoblasts will be isolated from human bone fragments coming from femoral heads discarded during total hip replacement surgery. The osteoblastic response to secreted factors released from medullary adipocytes of commercial origin will be analysed using conditioned media incubations. This phenotypic response will be quantified for each subject through the analysis of gene expression levels. Inter-subject phenotype variations will be related to bone density and microarchitecture data obtained by X-ray microtomography. This will assess the existence of a correlation between the osteoblast response to adipocyte secretions and the degree of osteoporosis of the subject from whom the cells are derived.


Eligibility Criteria:
Inclusion Criteria:

* Adult subject
* Surgical indication for hip prosthesis implantation
* Affiliation to a social insurance regime

Exclusion Criteria:

* Rejection of participation
* Diagnosed bone diseases other than osteoarthritis or osteoporosis
* Cancer
* Pregnant Women
* Subject under guardianship or trusteeship
* Subject unable to understand the study.
Rosiglitazone And Plaque Study for Type 2 Diabetes Mellitus

This is a phase IIIb, randomised, double blind, placebo controlled, study in patients with type 2 diabetes mellitus and coexisting vascular disease or hypertension. The total duration of the study will be approximately 60 weeks. The aim of this study is to examine the potential beneficial effects of rosiglitazone on carotid atheroma in patients with type 2 diabetes mellitus and coexisting vascular disease or hypertension. It is hypothesised that treatment with rosiglitazone will lead to an decrease in plaque size. In addition, it is hoped that rosiglitazone will have a positive effect on plaque composition and stability.


Eligibility Criteria:
Inclusion criteria:

* Type 2 diabetes.
* Co-existing vascular disease.
* At least 6 months of statin or fibrate therapy.
* HbA1c \<10% at screening and with at least one atheromatous plaque causing 10-95% narrowing of the internal carotid artery.

Exclusion criteria:

* Patients with \>2 concomitant oral anti-hyperglycaemic agents within 3 months of screening.
* Previous exposure to a thiazolidinedione.
* History of chronic insulin use.
* Use of investigational drug within 30 days.
* Systolic blood pressure (bp) \> 170 mmHg or diastolic bp \>100 mmHg.
* Severe or unstable angina.
* History of: gangrene, TIA, stroke, hepatic disease, alcohol or drug abuse, surgery of the carotid arteries or claustrophobia.
Efficacy and Safety of 14-day Concomitant Therapy for Helicobacter Pylori Infection

The purpose of this study is to evaluate efficacy of a 14-day concomitant therapy for the third-line treatment of Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates.

Helicobacter pylori infects half of the world's population. H.pylori eradication is an effective approach to reduce the risk of developing gastric cancer. However, eradication rates of first-line therapy decreased over years due to the rapidly increasing antibiotic resistance of H. pylori worldwide. An ideal rescue therapeutic regimen to cure refractory H.pylori infection is currently warranted.

Few published paper evaluated the efficacy of 14-day furazolidone containing concomitant therapy in the third line treatment. This study aims to propose a new concomitant therapy for the patients with two or more treatment failure, and then evaluates whether adverse effects are tolerable. .

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18-70 with persistent H. pylori infection.
* Patients failed at least three different standard eradication therapies before. Previous standard eradication therapy was defined as a 10-day or 14-day quadruple regimen designed according to Maastricht V report.

Exclusion Criteria:

* Patients unable or unwilling to receive gastroscopy.
* Patients treated with H2-receptor antagonist, PPI, bismuth and antibiotics in the previous 4 weeks.
* Patients with gastorectomy, acute GI bleeding and advanced gastric cancer.
* History of allergy to any of the drugs used in the study.
* Severe concomitant cardiovascular, respiratory, or endocrine diseases,clinically significant renal or hepatic disease, hematologic disorders and any other clinically significant medical condition that could increase risk.
* Currently pregnant or lactating.
* Severe neurologic or psychiatric disorders.
* Alcohol abuse or drug addiction.
* Patients with compliance lower than 90% in any previous treatment are not included.
* Inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.