cyrilzakka/clinical-trials huggingface dataset:
Brain Structural Abnormalities in Patients with Post-COVID-19 Headache

Introduction: The clinical manifestations of the COVID-19 pandemic are heterogeneous and may include various symptoms (gastrointestinal, musculoskeletal, neurological). Approximately 25% of patients report headache as a neurological symptom, making it the fifth most common symptom. These headaches may arise from structural brain changes associated with the infection.

Purpose: This study aims to identify the structural abnormalities observed in brain MRI that correlate with chronic headaches in patients who had COVID-19 infection.

Methods: The study included 30 patients with post-COVID-19 headaches and 30 control patients with no history of COVID-19. Demographic characteristics were analyzed using t-tests and chi-square tests. MRI findings were categorized into six types: cortical atrophy, white matter lesions, vascular lesions, lacunar lesions, vascular encephalopathy, and sinusitis. Differences in MRI findings between the two groups were evaluated using chi-square tests. Secondary outcomes included the analysis of symptoms accompanying headaches, diagnoses following MRI, and treatments applied.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years
* History of COVID-19 infection
* Persistent headache following COVID-19 infection
* Brain MRI requested by the attending physician

Exclusion Criteria:

* Prior neurological disease or disorder
* MRI contraindications (e.g., pacemaker, metal implants, claustrophobia)
Effect of Oxytocin Infusion on Blood Loss During Abdominal Myomectomy

To evaluate the effects of oxytocin infusion during abdominal myomectomy.

Myomectomy is indicated for symptomatic uterine fibroids. Fibroids have blood supply and 20% of the abdominal myomectomy cases might require blood transfusion because of the nature of the surgery. Oxytocin infusion is one of the intervention to decrease blood loss during myomectomy. To evaluate the effects and benefits of oxytocin infusion during abdominal myomectomy we decide to conduct this randomized study.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-50
* Patients who are candidate for abdominal myomectomy

Exclusion Criteria:

* History of previous myomectomy.
* Suspected malignancy
* Patients with preoperative anemia
* Patients using hormonal treatments before the surgery.
Feasibility of Implementing a Cohort of People Living With Hepatitis C in Vietnam

The purpose of this study is to evaluate the feasibility of implementing a cohort of patients with Hepatitis C in order to generate a larger cohort for future studies


Eligibility Criteria:
Inclusion Criteria:

* The patient must have given their free and informed consent and signed the consent form
* The patient is at least 18 years old
* The patient is HCV RNA positive

Exclusion Criteria:

-
Hypercapnia and Gas Exchange Under the Avalanche Snow Model (HyperAvaSM)

The aim of the study is to investigate respiratory parameters of a person in the simulated avalanche snow and consequent use of the measured data for development of a mathematical-physical model of breathing during increasing hypercapnia in the avalanche.

The study is a part of a university research project aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. Presence of an air pocket and its size play an important role in survival of victims buried in the avalanche snow. Even small air pockets facilitate breathing, yet they do not provide a significant amount of fresh air for breathing. The investigators hypothesize that the size of the air pocket significantly affects the airflow resistance and work of breathing. The aim of the study is to investigate the effect of the air pocket volume on gas exchange and work of breathing in subjects breathing into the simulated avalanche snow and to test, whether it is possible to breathe with zero air pocket.

Eligibility Criteria:
Inclusion Criteria:

* Participants were volunteers from the Czech Army forces, studying at the Military Department of the Faculty of Physical Education and Sport, Charles University in Prague. All subjects were healthy and fit, classified as ASA I, all without a smoking history. The volunteers were highly motivated to participate in the experiment. The entrance examination, completed before the start of the study, included these tests: electrocardiography, blood pressure, spirometry, and assessment of the health conditions and family anamnesis by a physician with a specialty in anesthesia and critical care.

Exclusion Criteria:

* The exclusion criteria were Tiffeneau Index less than 0.70 and any cardiovascular or respiratory condition.
Efficacy of the SeQuent®Please in the Treatment of De-novo Stenoses Versus Taxus™Liberté™

The aim of the trial is to assess the efficacy of the Paclitaxel-coated SeQuent®Please angioplasty balloon in the treatment of stenoses in native coronary arteries compared to a drug eluting stent.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years
* Clinical evidence of stable or unstable angina or a positive functional study
* Single, stenotic de novo lesion in a native coronary artery, type A or selected B1 (see 4.3.1.1 Definition of lesion types)
* Diameter stenosis \> 70% (visual estimate)
* Vessel diameter 2.5 - 3.5 mm
* Female patients can enter this study if they are post-menopausal for at least two years or have undergone hysterectomy or sterilization
* Signed patient informed consent form
* Patient's and treating physician's agree that the patient will return for all required post procedure follow-up assessments as defined in the clinical protocol

Exclusion Criteria:

* Left ventricular ejection fraction of \< 30%
* Visible thrombus proximal to the lesion
* Expection that treatment with devices other than PTCA will be required for this lesion.
* Stenosis is within a bypass graft
* Known hypersensitivity or contraindication to aspirin, heparin, clopidogrel, paclitaxel, or a sensitivity to contrast media which cannot be adequately pre-medicated
* Other medical illness (i.e. cancer, liver disease or congestive heart failure) that may require cytostatic or radiation therapy, cause the subject to be non-compliant with the protocol, confound the data interpretation or is associated with limited life-expectancy (i.e., less than two years).
* Acute myocardial infarction within the past 72 hours of the intended treatment (de-fined as: Q wave infarction having total creatinine kinase (CK) \>3 times the upper normal limit, or CK remains elevated above hospital normal at time of treatment)
* Chronic renal insufficiency with serum creatinine \> 2.0 mg%
* Significant gastrointestinal (GI) bleed within the past six months.
* History of bleeding diathesis or coagulopathy or will refuse blood transfusions
* Extensive peripheral vascular disease that precludes safe 6 French sheath insertion and / or requires additional anti-platelet and / or anti-coagulation treatment.
* Participating in another device or drug study within the last 6 months which may inter-fere with the interpretation of results of this study
Acmella Oleracea in the Analgesia of the Digital Rectal Examination

The aim of the study is to develop an herbal gel based on Acmella oleracea and do a comparative analysis to evaluate the intensity of pain during the digital rectal examination comparing to lidocaine gel group and ultrasound gel group.

The aim of the study is to develop an herbal gel based on Acmella oleracea and do a comparative analysis to evaluate the intensity of pain during the digital rectal examination comparing to lidocaine gel group and ultrasound gel group.

We are conducting a randomized, controlled, single-blind clinical trial of man undergoing to digital rectal examination, with 150 participants. Will be recruit at the Urologic Clinic of the Samuel Libânio Clinical Hospital and Urologic Clinic CISAMESP in Pouso Alegre. Participants divided into three groups, A. oleracea gel group, lidocaine gel group and ultrasound gel group. The digital rectal examination always performed by the same doctor, on the same position. A visual analogue scale (VAS) will be the standard method to evaluate the pain levels. The VAS will be explained to all patients, 0 = no pain and 10 = the most severe pain.

Eligibility Criteria:
Inclusion Criteria:

* Male patients
* Patients to agree to participate in the study

Exclusion Criteria:

* Diabetic, chronic kidney disease, with urogenital infections, using an indwelling urinary catheter, with history of anorectal diseases or surgeries, psychiatric patients and who refused to participate in the research
Theory-based Training to Promote Breast Cancer Screening

BACKGROUND: Breast cancer worries are important determinants in relation to behavior favoring breast cancer screening.

OBJECTIVE: To determine the effect of theory-based training to promote breast cancer screening among women with high and low levels of breast cancer worries.

DESIGN AND SETTING: Randomized controlled trial, conducted in two family health centers.

METHODS: In total, 285 women were recruited. Women with low levels of breast cancer worries were included in the first intervention group (112 women) and the first control group (112 women), while women with high levels of breast cancer worries were included in the second intervention group (37 women) and the second control group (43 women). Theory-based training to promote breast cancer screening was given to intervention groups. The women's willingness to undergo breast cancer screening and breast cancer worry scores were evaluated at 1, 3 and 6 months.

Breast cancer is the most frequent type of cancer and the most common cause of cancer death among gynecological cancers. One in every four women with cancer in the world has breast cancer. The International Cancer Agency reported that there were around 2,088,849 new cases and 626,679 deaths due to breast cancer worldwide in 2018. The incidence of breast cancer is higher in developed countries than in developing countries, but the numbers of deaths due to breast cancer are lower in developed countries than in developing countries.

It is known that breast self-examination, clinical breast examination and mammography play an important role in making an early diagnosis of breast cancer. The uptake rate for mammography performed on a regular basis is low because this is an expensive method, considering that not all individuals have health insurance and public funding is inadequate, especially in developing countries. Hence, breast self-examination (which has no cost) and clinical breast examination (which only has low cost) remain important diagnostic methods. Moreover, during clinical breast examination, healthcare professionals have the opportunity to advise on breast cancer, risk factors, prevention methods and screening methods.

Eligibility Criteria:
Inclusion Criteria:

* The participants included did not have any diagnosis of breast cancer, had not been performing breast self-examination regularly (every month), had not previously had a mammogram, had not previously had a clinical breast examination, were not pregnant or breastfeeding and were literate.

Exclusion Criteria:

* Missing data collection forms.
The Efficacy of PD-1 Antibody Sintilimab on Early-stage Multiple Primary Lung Cancer With Ground Glass Density.

A single-center,prospective interventional study to explore the efficacy of PD-1 antibody Sintilimab on early-stage multiple primary lung cancer patients with ground-glass nodules in CT scan.

This study is a single-center,prospective interventional clinical study, all subjects enrolled are multiple primary lung cancer patients with ground-glass density in CT scan.The samples plan for the study was 36 cases.The enrolled patients will receive intravenous infusion of Sintilimab 200mg every 3 weeks up to 4 cycles, and the efficacy will be evaluated after cycle 2 and 4 using RECIST criteria (version 1.1 ).

Eligibility Criteria:
Inclusion Criteria:

* Two or more ground-glass lesions (pure ground glass or partially solid) presented in the CT scan of lung that cannot be operated simultaneously
* There was at least one lung cancer lesion with a diameter of 1-3cm confirmed pathologically or by multidisciplinary team.
* Excluding lymph nodes and distant metastasis through imaging
* ECOG PS 0-1
* Vital organ functions meet the following requirements: 1)The absolute count of neutrophils ≥1.5×109/L 2)Platelet ≥90×109/L 3)Hemoglobin ≥9g/dL 4)Serum albumin ≥3g/dL 5)Thyroid stimulating hormone (TSH) ≤ULN (if abnormal, T3 and T4 levels should be examined at the same time; if T3 and T4 levels are normal, they can be included in the group) 6)Bilirubin ≤ULN 7)ALT and AST≤1.5 ULN 8)AKP≤ 2.5ULN or less 9)Serum creatinine ≤1.5 ULN or creatinine clearance ≥60mL/min
* Subjects volunteered to participate in this study and signed informed consent, with good compliance.

Exclusion Criteria:

* Non-calcified lesions with diameter more than 3mm are presented
* The presence of any active autoimmune diseases or a history of autoimmune diseases
* Those who have used other drugs in clinical study within 4 weeks before the first time of drug use
* Severe allergic reaction to monoclonal antibody
* Heart clinical symptoms or diseases are not well controlled
* Subjects with congenital or acquired immune deficiency (such as HIV infection) or active hepatitis
* According to the researcher's judgment, the subjects have other factors that may lead to the forced termination of this study
Ozone Therapy in Endodontic Practice, in Vivo Study

The ozone therapy has been coming up as a new therapeutic modality. Medicine has been practicing since XIX century and counted great results. It is indicated for the treatment of 260 different pathologies. The researches in Dentistry has showed promising results, indicating a wide spread action in whole dental specialties. The great oxidative power of ozone provides a great antimicrobial effect and it increases the adenosine triphosphate (ATP) synthesis that can be considered as a general improvement of the cell metabolism, which can potentize the repair process. Thus, these facts justify the present study which will assess the increase of speed of apical periodontite repair.


Eligibility Criteria:
Inclusion Criteria:

* Healthy patients
* Radiographic evidence of apical periodontite
* No previous root canal treatment

Exclusion Criteria:

* Unhealthy patients
* Regular response to sensibility test
* Previous root canal treatment
Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis

This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.


Eligibility Criteria:
Inclusion Criteria:

* Able to provide informed consent (or have consent provided through a guardian)
* No immune-modulating drug use during study or within 30 days prior to enrollment
* Having colon material collected as part of standard of care

Exclusion Criteria:

* Unable to provide informed consent (or have consent provided through a guardian)
* Not having colon material collected as part of standard of care
Development of a Space Exploration Assessment for Children With Spinal Muscular Atrophy

The aim of this randomized study is to develop a new motor assessment of space exploration in a 2D environment with upper limbs for children with spinal muscular atrophy 1 and 2 from 3 until 16 years old.

Thirty children are included in the prospective randomized study. They are evaluated with the new test, Space Exploration Test (TES), and with the Motor Function Measure (MFM), a gold standard scale. The objective is to compare the results and to demonstrate the complementarity of the two tools.

Eligibility Criteria:
Inclusion Criteria:

* children, girls and boys, from 3 to 16 years old,
* with Spinal Motor Atrophy 1 and 2
* with social protection

Exclusion Criteria:

* cognitive disorders preventing understanding
Impact Evaluation of the Pilot SMS Mother Reminder System

The study aims to assess the effects of the SMS Mother Reminder system on use of health care in Uganda. A secondary aim of the study is to determine the behavioral factors and cost-effectiveness, as well as test the usability of the SMS Mother Reminder in Uganda.

USAID/Uganda is commissioning a prospective impact evaluation of the initial SMS component of Uganda's National Health Record Program (NHRP) in order to inform strategic targeting of eHealth and future investments after the pilot phase of the NHRP mobile platform "SMS Mother Reminder". This impact evaluation will be designed to answer the following questions:

Primary evaluation question:

• What is the effect on maternal health outcomes (ANC4 and IPTP2) of the village health teams' use of the SMS Mother Reminder system?

Secondary evaluation questions:

* What factors most influence changes in health workers, village health teams and expectant women's knowledge, attitudes and practices in maternal health?
* To what extent is using the SMS Mother Reminder application to track and inform pregnant women a cost-effective intervention from the perspectives of USAID?
* To what extent can users easily carry out specific tasks (e.g. entering the information of pregnant women) of the SMS Mother Reminder application on mobile devices?

This study is funded by USAID through the African Strategies for Health project.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant

Exclusion Criteria:

-
Variable Resistance Training in Patients With Osteoarthrosis of the Knee

This is a randomized controlled trial investigating the effect of variable load training in patients with knee osteoarthrosis.

The intervention will consist of resistance training with variable load in knee extension- and flexion. The control group will receive conventional strength training with rubber band.

Outcome measures will be the Knee Osteoarthrosis Outcome Score, functional capacity measured in a sit to stand test, 30m. pace walk and a 9 step stair climb test. Additionally isometric strength in knee flexion- and extension will be measured.


Eligibility Criteria:
Inclusion Criteria:

* Knee pain and minimum three of the following
* \>50 years
* morning stiffness \< 30 min
* crepitation
* bone tenderness
* bone osteophytes
* absence of inflammation

Exclusion Criteria:

* Other causes of symptoms to the knee
R-BMD in Refractory or Relapsed Lymphoma, GELTAMO Clinical Trial

Assess the combination of efficacy of the combination of rituximab, bendamustine, mitoxantrone, dexamethasone in the treatment of patients with Follicular Lymphoma.

Assess the combination of efficacy and safety of the combination of rituximab, bendamustine, mitoxantrone, dexamethasone in the treatment of patients with Follicular Lymphoma who are refractory or in relapse.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥ 18 and ≤ 75 years.
2. Patients with follicular lymphoma grade 1, 2 or 3a, CD20 +, histologically confirmed lymph node biopsy or tissue. Be accepted diagnosis in bone marrow if no accessible lymph nodes and whether it has discarded the mantle LLC, and NHL.
3. Follicular lymphoma patients treated with the combination of rituximab and chemotherapy in first line, which have been refractory or relapsed after having achieved any responses to this first line of pretreatment (excluding radiotherapy).
4. ECOG ≤ 2.
5. Signed written informed consent.

Exclusion Criteria:

1. Clinical suspicion or documentation of histological transformation.
2. Have received prior chemotherapy scheme, first line without Rituximab.
3. Prior autologous or allogeneic.
4. CNS infiltration by LF (primary CNS lymphoma or lymphomatous meningitis).
5. Past or active Hepatitis B (at least one of the following markers HBsAg, HBe Ag, anti-HBc, HBV DNA)
6. HCV infection. HIV infection or other conditions of serious immunosuppression.
7. Previous neoplasms except non-melanoma skin cancer of the cervix or adequately treated.
8. Cardiac function in cardiac patient known or prior treatment with anthracyclines with EF \<50%.
9. Impaired renal function (creatinine\> 1.5 x Upper Limit of Normal, LSN) or a creatinine clearance \<50 ml / h, not related to lymphoma.
10. Impaired liver function (bilirubin, AST / ALT or GGT\> 2 x ULN) were not related to lymphoma.
11. Women who are nursing or pregnant. Women of childbearing potential will be included prior pregnancy test serum / urine negative. Use effective contraception to be kept for 1 year after cessation of rituximab.
12. Patients with heart disease, pulmonary, neurological, psychiatric or severe metabolic and not secondary to lymphoma.
13. Severe acute or chronic infection in activity.
14. Any other concurrent medical or psychological comorbidity that might interfere with participation in this study.
Inguinal Hernia Operation and Postoperative Pain

Inguinal hernia is a common disease, which is treated surgically when symptomatic. Pain after open inguinal hernia surgery can affect the patient significantly and weaken their quality of life. The aim of this study is to find out if the choice of mesh affects postoperative pain and therefore causes more contacts to the health care center. Our goal is also to find out how the pain affects the patients´ quality of life.


Eligibility Criteria:
Inclusion Criteria:

* 18-80 years old male patients, with a symptomatic inguinal hernia that can be diagnosed by clinical examination. Primary and unilateral hernia. The operation performed at a day surgery unit.

Exclusion Criteria:

* female
* bilateral hernia
* Incarcerated hernia
* Scrotal hernia
* ASA-classification \>3
* BMI \>35 or \<18
* No hernia found in clinical examination
* Liver cirrhosis
* Other contraindication for inguinal hernia operation
* Anticoagulant therapy, that needs bridge therapy when paused
Pilot Study of Multi-Modality Imaging in Patients With Hematologic Malignancies

This is a pilot sub-study of patients receiving myeloablative transplant using total body irradiation (TBI) or total marrow irradiation (TMI) in their preparative regimen. The objective of this stub-study is to estimate the heterogeneity in cellular proliferation (FLT-PET uptake) as well the heterogeneity in marrow composition distribution (measured using whole body water-fat MRI) using positron emission tomography imaging. This will be used to design future trials as well as to determine the feasibility of PET and MRI imaging.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of hematologic malignancy and fitting into one of the following categories:

  * Newly diagnosed and/or day 14 post-induction chemotherapy
  * Relapsed, including relapse after hematopoietic cell transplant
  * Planned hematopoietic cell transplant (if enrolling at "close") or within 100 days post hematopoietic cell transplant (if enrolling post-transplant) with a preparative regimen that includes either total marrow irradiation (TMI) or total body irradiation (TBI)
  * Undergoing natural killer cell therapies (with or without subsequent transplant)
* Aged 18 years and older
* Not pregnant - women of childbearing potential will have a confirmatory pregnancy test prior to each imaging per routine procedures
* Adequate renal function (estimated glomerular filtration rate \> 60 ml/min) as determined by a serum creatinine level performed as a part of standard of care within 7 days of imaging
* Able and willing to provide written consent

Exclusion Criteria:

* Otherwise eligible patients meeting one or more of the contraindicates for an MRI, may enroll in the study without undergoing the MRI:

  * ferromagnetic implants
  * history of shrapnel or shot gun injury
  * too large to fit in the magnet (approximate body mass index ≥ 40)
  * cardiac pacemakers or other implanted devices that are not MR-compatible
  * claustrophobia
  * large tattoos