cyrilzakka/clinical-trials huggingface dataset:
The Impact of Chronic Adolescent Skin Conditions on Sexual Health

Background: Skin conditions are common in young people and are known to adversely affect emotional well-being and quality of life in a range of ways, including negative impact on intimate relationships. However, despite its importance, it has been shown that dermatology consultations rarely address issues like genital skin involvement or sexual dysfunction. Furthermore, there is currently very little data on the scale of the problem, risk factors, psychological impact of skin on sexual function or understanding of the most appropriate ways to manage it in this age group.

Research aims: The Dermatology department at Oxford University Hospitals National Health Service Trust (Oxford, United Kingdom) have already set up an award-winning specialist dermatology service for young people with embedded psychological support. This study further explores how services can be improved by evaluating the impact of chronic skin conditions on quality of life and sexual dysfunction in adolescents. By identifying the associated risk factors, recommendations can be made to effectively meet the physical and mental health needs of adolescents.

Design and methods: The study will gain perspectives from follow-up patients aged 17 - 25 years seen by the Dermatology departments in Oxford University Hospitals National Health Service Trust (Oxford, United Kingdom). They will complete an online anonymous survey to share how their skin condition affects their quality of life, including sex and intimacy, and how services can be improved to meet their needs. In-depth interviews will then be conducted in those who volunteer, to better understand the nuances of unmet needs. Participation is voluntary.

Dissemination: Results of the research will be disseminated by national and international conferences, publications in academic dermatology journals and collaborations with other NHS departments. Improvements will be made to the local adolescent dermatology service as a result and shared via local meetings and posters.


Eligibility Criteria:
Inclusion Criteria:

* The participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged 17-25 (inclusive).
* Diagnosed with a long-term skin condition and seen as a follow-up patient in the clinic.
* Recruited from Paediatric/Adolescent, General and Acne clinics under the Oxford University Hospitals National Health Service Trust Dermatology Department.
* Fluent in English (reading and writing).

Exclusion Criteria:

* No informed consent was given to participate in the study or use the data for research purposes.
* No capacity to make an informed decision to consent.
Impact of Transcranial Direct Current Stimulation on the Capacity to Perform Burpees

Introduction and Background:

Transcranial direct current stimulation (tDCS) has emerged as a potential intervention to improve physical performance. The primary aim of this study is to investigate the effects of tDCS applied to the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) on performance in a maximal effort task, specifically the No Jump Burpee exercise.

Study Design:

This study will utilize a double-blind crossover design, where each subject will complete three experimental conditions: a-DLPFC, a-M1, and SHAM.

Participants:

Twenty healthy male subjects will be recruited for the study.

Intervention:

Each participant will undergo three conditions in a randomized order:

a-DLPFC: tDCS applied to the dorsolateral prefrontal cortex.

a-M1: tDCS applied to the primary motor cortex. SHAM: Placebo stimulation.

Procedure:

Prior to performing the No Jump Burpee exercise to exhaustion, tDCS will be administered at a current of 2 milliampere (mA) for 20 minutes.

Measurements:

The following variables will be measured during the exercise:

Total number of repetitions of the No Jump Burpee exercise. Vastus lateralis muscle oxygen saturation. Heart rate. Subjective perception of exertion (RPE).

Data Analysis:

Repeated measures ANOVAs will be used to analyze the effects of the different tDCS conditions on the performance outcomes.

Ethical Considerations:

The study protocol will be reviewed and approved by an appropriate ethics committee. Written informed consent will be obtained from all participants before participation in the study.

Objectives:

The primary objective is to evaluate the impact of tDCS on physical performance, specifically measuring the total number of repetitions of the No Jump Burpee exercise. Secondary objectives include assessing the changes in muscle oxygen saturation, heart rate, and subjective perception of exertion.


Eligibility Criteria:
Inclusion Criteria:

* Healthy subject.
* No use of any ergogenic substance.
* Participants must be recreationally active, defined as engaging in moderate physical activity at least 3 times per week for the past 6 months

Exclusion Criteria:

* Any contraindications to transcranial Direct Current Stimulation, such as metallic implants in the head, active implanted medical devices (e.g., pacemakers), or skin conditions affecting the scalp.
* Current or recent (within the past 6 months) substance abuse, including alcohol or recreational drugs.
* Musculoskeletal injury within the past 6 weeks.
* Lower extremity pain above 3 or more according to numeric pain scale.
* History of epilepsy or convulsive crisis.
Colorectal Polyp Resection Adequacy

The purpose of this study is to determine the best way to ensure that polyps are completely removed by evaluating the borders of the removed polyp. If a polyp is found that meets the size requirements for the study, the investigators will take extra biopsies of the margin to determine if there is any abnormal tissue or cancer at these borders.


Eligibility Criteria:
Inclusion Criteria:

* Age 40-80

Exclusion Criteria:

* Coagulopathy (international normalized ratio \>2)
* Inflammatory bowel disease or other active colitides
* Polyps of index colonoscopy that were felt not to be completely resected or pedunculated
* Familial adenomatous polyposis or hereditary polyposis
* Potential hereditary cancer syndrome (Lynch Syndrome)
Epidemiological Study on Malignancy Complicated With Renal Injury

The epidemiological study of tumor complicated with kidney disease can clarify the prevalence and risk factors of renal injury when malignant tumor is diagnosed, and understand the impact of malignant tumor complicated with renal injury on survival time. This study will bring enlightenment to clinicians, discover high-risk factors in time, and try to avoid renal damage factors in diagnosis and treatment. Early diagnosis and early treatment can partially terminate the progress of renal injury, avoid the suspension of treatment due to renal reasons, and avoid the occurrence of end-stage renal failure (ESRD).

1. To determine the prevalence of malignant tumor complicated with renal injury and analyze the related risk factors.
2. To compare the survival time of malignant tumor with or without renal injury

Eligibility Criteria:
Inclusion Criteria:

* Malignancy confirmed by pathology.
* Between 18-80 years old, regardless of gender; Patients initially diagnosed with malignant tumors in our hospital from July 2017 to June 2021; Waiver of informed consent.

Exclusion Criteria:

* Patients with benign tumor diagnosed by pathology; The patient refused to participate; Patients judged by other researchers as unsuitable for inclusion in the study.
The Effects of Acupuncture Against Postoperative Nausea and Vomit After Laparoscopic Cholecystectomy

Postoperative nausea and vomiting (PONV), represents a common condition after surgery and anesthesia. Acupuncture has been used for centuries for analgesia and quality of life improvement in addition to low cost. This study is a random control trial concerning the antiemetic efficacy of acupuncture associated with intravenous antiemetics in laparoscopic cholecystectomy, in comparison to patients under only antiemetic administration.

One hundred patients were enrolled, regardless of their sex, age, and comorbidity and were randomly allocated in one of two groups. Both anesthesia and antiemetic medication were personalized according to each patient's medical history. In the study group, after anesthesia induction and before pneumoperitoneum application, a sterile stainless steel 0,25 x 25mm acupuncture needle was inserted bilaterally at the PC6 for 20 minutes, rotated manually clockwise and then anticlockwise every 5 minutes and then removed. Fisher's exact test was chosen for statistic evaluation.

There were 8 PONV cases in the study group against 18 cases in the control group. Fisher's exact test highlighted a p-value of P=0,03, marking the difference between the two groups as statistically significant.

Concluding, acupuncture presents a remarkable action against PONV after Laparoscopic Cholecystectomy (LPC). Another remarkable trait of acupuncture is the safety that it offers during application without provoking severe adverse effects. Furthermore, reduced medical costs thanks to decreased postoperative use of antiemetic medication, decreased patients' hospitalization, and reduced re-hospitalization possibility have to be noted. Finally, it has to be mentioned that despite LPC is in general terms painless, the analgesic effects of acupuncture should not be disregarded


Eligibility Criteria:
Inclusion Criteria:

* Adult Male patients undergoing laparoscopic cholecystectomy regardless of other comorbidities.
* Adult Female patients undergoing laparoscopic cholecystectomy regardless of other comorbidities.
* To be able to communicate with personnel.

Exclusion Criteria:

* Patients under 18 years old.
* Inflammation of acupuncture site (PC6).
* Inaccessible acupuncture site (eg. arm amputees, trauma).
* Patients unable to communicate with personnel.
[Impedance Measurement for Non-Erosive Reflux Disease

This study is being done to determine if people with and without GERD or trouble swallowing have increased esophageal mucosa impedance (food getting into the esophageal tissue).

In patients with gastroesophageal reflux disease (GERD) but without gross evidence of esophageal injury, confirmation of acid reflux is typically performed through testing that measures reflux at or proximal to 5 cm above the gastroesophageal junction. These tests such as pH/impedance monitoring and Bravo probe placement in the esophagus have been the gold standard for diagnosing and quantitating the degree of gastroesophageal reflux. This stands in contrast to the concept that the esophagus distal to 5 cm is first and foremost exposed to gastroesophageal reflux and that most injury in the form of erosive esophagitis is seen in the 4cm segment below where this instruments measure reflux. As a result, this type of testing may not allow for full understanding of the pathophysiology of GERD. Furthermore, with refluxed acid exposure limited to the distal esophagus in some patients, use of conventional pH testing could lead to inaccurate diagnosing of GERD.

Esophageal impedance testing measures epithelial integrity as reflected through the ability of the mucosa to conduct electric current. As dilation of intercellular spaces in biopsies from patients with GERD is considered the earliest indication of esophageal injury in response to reflux in the absence of gross endoscopic injury, the measure of increased current conduction through these dilated spaces has been shown to be an accurate means of diagnosing patients with non-erosive reflux disease. To this point, most esophageal impedance has been measured using impedance ports placed at locations similar to the pH probes in a combined intra-esophageal ambulatory catheter. As a result, the most distal point of impedance measurement is also 5 cm above the gastroesophageal junction. Recently, a site specific endoscopically placed impedance probe has been developed that can measure esophageal mucosal impedance at any point of the esophagus.

In this study the Principal Investigator would like to look at patients with and without reflux symptoms measuring impedance at 1,2,3,4 and 5 cm at the 6 o'clock position above the Gastroesophageal Junction.

Eligibility Criteria:
Inclusion Criteria:

* Adults ages 18-90
* Patients with heartburn and no hiatal hernia undergoing clinically indicated endoscopy
* Patients with heartburn and a hiatal hernia \> 3cm undergoing clinically indicated endoscopy
* Patients undergoing clinically indicated upper endoscopy for indications other than dysphagia or GERD
* Patients with reflux symptoms, a normal appearing esophagus on clinically indicated endoscopy undergoing clinically indicated ambulatory pH/impedance testing.

Exclusion Criteria:

* Previous gastric or esophageal surgery.
* Use of proton pump inhibitors 1 month prior to the study
* Patients on anticoagulation other than aspirin or clopidogrel
* Presence of erosive esophagitis or Barrett's esophagus
Effect of Platform Swing Walkway on Locomotor Behavior in Diplegic Children

Locomotor activity is accompanied by a number of sensory stimuli: visual, auditory, olfactory, vestibular, and somatosensory. When improving motor skills, incorporating postural reflexes, creating synchronized eye movements, and visual attention skills, the vestibular system is particularly important.

Thirty diaplegic cerebral palsied children of both sexes, ranged in age from 3 to 6 years enrolled in this study. They randomly assigned into two groups of equal number; control group (A), study group (B). Group (A) groups received the conventional physical therapy program based on neurodevelopmental approach for such cases. Whereas study group (B) received the same conventional physical therapy program given to group (A) in addition to gait training on platform swing walkway for 30 minute. All children were assessed before and after the treatment program by using 2D video based gait assessment system to measure the percentage of swing and stance phase, also GMFM was used to assess standing and walking, running, and jumping abilities, domains (D) and (E).

Eligibility Criteria:
Inclusion Criteria:

* were cognitively competent
* able to understand and follow instructions.

Exclusion Criteria:

* if they had fixed contractures
* deformities of the spine, upper or lower extremities,
* visual or respiratory disorders.
PENG Block for Total Hip Arthroplasty

This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the pericapsular nerve group block on postoperative rehabilitation.

The pericapsular nerve group, or PENG block, has been recently described and shows promise in providing analgesia to the hip joint. However, the effect of this block on postoperative rehabilitation is uncertain. This study compares a preoperative PENG block to a placebo before total hip arthroplasty under spinal anesthesia. The primary outcome measure is verticalization, walking distance, ability to go out of bed, active lifting of the limb, range of motion in the hip joint, bending range of motion, and abduction range of motion. The secondary measure is postoperative pain assessment during rehabilitation.

Eligibility Criteria:
Inclusion Criteria:

* Patients \> 18 years old undergoing unilateral total hip arthroplasty

Exclusion Criteria:

* refusal to participate
* \< 18 yo
* Chronic opioid use
* localized infection
Effectiveness of Combination of Arimidex and Nolvadex in Adjuvant Therapy of Breast Carcinoma in Postmenopausal Women.

The purpose of this study is to determine the efficacy and tolerability of 3 years treatment with anastrozole after a prior 2 years' treatment with tamoxifen versus 5 years treatment with tamoxifen in postmenopausal women with early breast cancer


Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent,
* Post-menopausal women ≤75 years,
* histologically confirmed invasive breast carcinoma (no distant metastases),
* positive hormone receptor status,
* continuous 2-year adjuvant tamoxifen therapy 20 mg/30 mg with 4 weeks after primary surgery

Exclusion Criteria:

* menopause status maintained by medication,
* pre-operative chemotherapy or hormone therapy or radiation therapy,
* relapse or second carcinoma or previous cancerous disease,
* breast carcinoma in situ,
* simultaneous carcinoma of the opposite side or secondary breast,
* 10 or more tumour-infiltrated lymph nodes.
* serious accompanying diseases
Pan-canceR Early-Stage deteCtion by lIquid Biopsy tEchNique projecT

PRESCIENT is a multi-center, prospective observational study aimed to detect cancers early by combined assays for serum protein markers and cell-free DNA (cfDNA) methylation markers. Blood RNA markers will also be evaluated. The study will enroll approximately 11879 participants, including participants with malignancies or benign diseases, and healthy participants.


Eligibility Criteria:
Inclusion Criteria for All the Participants:

* Ability to provide a written informed consent
* 40-75 years old

Exclusion Criteria for All the Participants:

* Inability to comply with study procedures
* Pregnancy or lactating women
* Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant
* Recipients of blood transfusion within 7 days prior to study blood draw
* Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer

Inclusion Criteria for Cancer Arm Participants:

* Confirmed diagnosis or suspicious cases of one of the 22 types of malignancies within 42 days prior to study blood draw
* No prior or ongoing anti-cancer therapy (local or systematic) prior to study blood draw

Exclusion Criteria for Cancer Arm Participants:

* Known prior diagnosis of malignancies
* Other current malignant diseases or multiple primary tumors
* No confirmed diagnosis of cancer by histopathological or radiological assessments within 42 days of study blood draw, or diagnosis of a benign disease by histopathological assessments, or inability to characterize whether the lesion is malignant or benign
* Non-small-cell lung cancer patients with ground-class nodularity by radiological examination

Inclusion Criteria for Benign Diseases Arm Participants:

* Confirmed diagnosis of benign diseases corresponding to the tumor types in the Cancer Arm by histopathological or radiological assessments within 90 days prior to study blood draw
* No prior treatment of benign diseases prior to study blood draw

Exclusion Criteria for Benign Diseases Arm Participants:

* History of malignancies
* Current malignancies or precancerous lesions
* No confirmed diagnosis of a benign disease by radiological, endoscopic or histopathological assessments within 42 days of study blood draw, or inability to characterize whether the lesion is malignant or benign

Inclusion Criteria for Non-tumor (Healthy) Arm Participants:

* No cancer-related symptoms or discomfort within 30 days prior to study blood draw
* No clinically significant finding by LDCT or ultrasound
* No clinically significant finding by breast ultrasound or Molybdenum Target Mammography Detection, or Thinprep cytologic test (TCT) detection for female participants
* No active hepatitis B or hepatitis C infection

Exclusion Criteria for Non-tumor (Healthy) Arm Participants:

* Prior or ongoing treatment of cancer within 3 years prior to study blood draw
* Clinically significant or uncontrolled comorbidities
Correlation of Pre- and Post-operative Cancer Imaging Techniques

Various imaging modalities are used in medical diagnosis such as MRI, CT and PET. The images are sometimes acquired at different times and in different body positions, and thus need to be aligned for precise diagnosis and treatment planning. Different image modalities provide complementary information about the anatomical structure under study. Image registration techniques enable multimodality images to be projected onto a common coordinate system, so that these images can be aligned and spatial correspondences can be established between the images.

This research project aims to investigate the information provided by functional PET and CT images about the tumour environment in lung cancer patients by registering functional PET and CT images with the pathology images acquired from the same patient. On identification of specific region of interest on the functional imaging the investigators will then be able to interrogate the tumour biology. In many cancers, the tumour environment is usually composed of a heterogeneous mass of tissue. The discrimination and classification of the carcinoma substructures is of paramount importance in the radiotherapy planning stage, as a given treatment may be more or less suitable depending on the local characteristics of the tumour. For instance, in hypoxic regions (areas inside the tumour with very low oxygen supply), radiotherapy performs poorly and strategies to intensify treatment to those areas could be investigated.

This project will develop a framework for automatic registration of pathology images, which are taken from a surgically extracted lung tumour, with the corresponding PET/CT scan acquired from the patient before surgery. The registration of these images is essential for the evaluation of the performance of different PET radiotracers.


Eligibility Criteria:
Inclusion Criteria:

* Patient diagnosed with primary lung cancer and are due to undergo curative surgical resection of the tumour
* At least one of the tumour's major axes is larger than 30mm.
* The main volume of the tumour is located within the lung tissue.
* Tumour is identified primarily as single mass lesion.

Exclusion Criteria:

* Patient is under 18 years old.