cyrilzakka/clinical-trials huggingface dataset:
Iressa in Poor Performance Status Patients With Previously Untreated Advanced Non-Small Cell Lung Cancer

Because of the demonstrated single agent activity and excellent tolerability in patients with refractory non-small cell lung cancer, ZD1839 may be of benefit in the first-line treatment of patients with advanced non-small cell lung cancer who have poor performance status. In this phase II trial, we will investigate the single agent activity of first-line ZD1839 in patients with advanced non-small cell lung cancer with poor performance status

Upon determination of eligibility, patients will be receive:

* ZD1839

Eligibility Criteria:
Inclusion Criteria:

To be included in this study, you must meet the following criteria:

* Biopsy proven non-small cell lung cancer
* Recurrent non-small cell lung cancer after previous surgery or radiation
* Advanced disease (stage IIIb or IV)
* No previous chemotherapy or biological therapy
* Require significant assistance with activities of daily living
* Measurable disease
* Adequate bone marrow, liver and kidney function
* Give written informed consent

Exclusion Criteria:

You cannot participate in this study if any of the following apply to you:

* Brain metastasis
* Meningeal metastasis
* Other uncontrolled malignancies
* Women pregnant or lactating
* No measurable disease outside previous radiation therapy field

Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
Effectiveness of Scapular Muscle Training in Improving Grip Strength Among Lateral Epicondylitis Patients

The effectiveness of scapular muscular training along with conventional physiotherapy on the improving the grip strength of the patients suffering with the lateral epicondylitis was assessed by diving 56 patinets in two grousp as Group A (n=28) was treated with conventional physiotherapy treatment and Group B (n=28) was treated with Scapular strengthening and conventional physiotherapy protocol.


Eligibility Criteria:
Inclusion Criteria:

* Age: 20-50 years
* Gender: Male and Female
* Pain on the lateral epicondyle
* VAS scoring more than 4
* Positive test: Tomson test, Mill's test , Cozen;s sign and Maudsley's test

Exclusion Criteria:

* Any neurological/ Radiculopathy signs in upper limb
* Cervical pain
* Bilateral elbow pain
* History of elbow or wrist surgery
* Receiving any corticosteroid injection within last 6 months
An Observational Study of CPT-11 Based Regimens and UGT1A1 Genotypes in Metastatic Colorectal Cancer (mCRC)

The purpose of this study is to examine the correlation between UGT1A1 genotypes and the efficacy of CPT-11 based regimens (FOLFIRI, CPT-11+S-1, CPT-11) for patients with metastatic colorectal cancer.


Eligibility Criteria:
Inclusion Criteria:

* Metastatic colorectal cancer (adenocarcinoma)
* UGT1A1 genotyped patients
* Patients to receiving FOLFIRI, CPT-11+S-1 and CPT-11 alone therapy (with or without molecular targeted agents)

Exclusion Criteria:

* Contraindication of CPT-11
* Eastern Cooperative Oncology Group (ECOG) Performance Score (PS) 3-4
* Patients to receiving CPT-11 as adjuvant chemotherapy
* History of pelvic irradiation
Comparison of Efficacy of Triple Regimen Based on Clarithromycin VS Metronidazole in Children

All children from 1day to 18years of age, diagnosed with peptic ulcer disease due to H pylori at Pakistan Institute of Medical Sciences, Islamabad, from July 2020 to December 2021 will be included in the study. After informed written consent from parents/ guardians patients' bio data along with history and examination will be recorded on a proforma. They will be allocated into two groups, group A and group B randomly based on treatment regimen offered.

Group A: Amoxicillin AMO + Clarithromycin CLA + Proton pump inhibitor PPI) Group B: Amoxicillin AMO+ Metronidazole MET+ Proton pump inhibitor PPI The history will include presenting symptoms along duration, remission of symptoms after therapy and clinical outcome will also be recorded.

Helicobacter pylori is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide1. In general, the prevalence is high in developing countries and the infection is acquired at a young age. Most children infected with H pylori are asymptomatic. Antral gastritis is the most common manifestation in children. Duodenal and gastric ulcers may be associated with H pylori gastritis in 1.8 % children2. Antibiotic resistance is the major cause of failure in the treatment of H pylori infection3. Most of the studies worldwide confirmed an increase in macrolide resistance, while metronidazole resistance either decreased or remained stable. In a prospective multicenter European study, primarily comprised of adults, found a 31.8% resistance rate to clarithromycin and 25.7% to metronidazole in the study4.

If the strain is resistant to one of the antibiotics used, treatment success will be compromised5. As a result therapies that are recommended should be based on antibiotic susceptibility testing. If this testing is not available, then clarithromycin-based triple therapy should not be used as part of first-line therapy due to high rates of clarithromycin resistance rates6 The European Society for Paeditric Gastroenterology Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition made the recommendations in 2017 for the Management of Helicobacter pylori in Children that antimicrobial sensitivity should be obtained for the infecting H pylori to tailor eradication therapy accordingly and the effectiveness of first-line therapy should be evaluated in national/regional centers7.

If the strain is susceptible to clarithromycin (CLA) and to metronidazole (MET), triple therapy (PPI, amoxicillin \[AMO\], CLA) for 14 days and doses of proton pump inhibitor and antibiotics should be calculated based on the bodyweight8.

We aim to study efficacy and safety of clarithromycin vs metronidazole based triple regimen for the eradication of H pylori in children with peptic ulcer disease.

Eligibility Criteria:
Inclusion Criteria:

* 1. All children age 1-12 years having H-pylori gastritis

Exclusion Criteria:

* drug induced gastritis critically ill child
Intra-operative Adverse Events During Laparoscopic Ventral Mesh Rectopexy

Outcomes of laparoscopic ventral mesh rectopexy are well known, but data on intra-operative adverse events is scant. A multicenter pool-analysis of prospectively collected database on 1384 patients with internal/external rectal prolapse toke place. Overall 72 (5%) patients experienced complications, 41 discovered and managed intraoperatively, 22 postoperative complications, and 9 required readmission. Despite accepted lower rate of morbidity, these results come from four well equipped European centers by four surgeons practiced at least 200 LVMR.

Multicenter pooled-analysis of LVMR for internal/external rectal prolapse. All events occurred and discovered intra-operatively or passed undiagnosed and appeared within 30-days postoperatively (same admission/readmission) will included, with classification according to the Clavien-Dindo classification.

Eligibility Criteria:
Inclusion Criteria:

* all patients underwent laparoscopic ventral mesh rectopexy for internal and external rectal prolapse

Exclusion Criteria:

* other condition than rectal prolapse
Combined 25-gauge Vitrectomy and Cataract Surgery With Toric Intraocular Lens With Idiopathic Epiretinal Membrane.

Toric intraocular lens (IOL) is now widely used for the cataract surgery with preoperative corneal astigmatism.

Symptomatic epiretinal membrane (ERM) is often treated with 25-gauge transconjunctival sutureless vitrectomy, resulting in good visual recovery. So far, however, limited information is available on the the stability of axis rotation, astigmatism correction, and improvement in uncorrected distance visual acuity, using astigmatism-correcting IOL in a 25-gauge transconjunctival sutureless vitrectomy combined with cataract surgery. In the current study, eyes with a preoperative corneal cylinder of more than 0.75 diopter had a triple procedure for idiopathic ERM using a toric IOL. Outcome measures will be the amount of IOL axis rotation, uncorrected visual acuity, corrected distance visual acuity, and corneal and refractive astigmatism up to 6 months postoperatively. We are expecting to show that postoperative IOL axis stability is similar to that reported for cataract surgery alone in vitrectomy (triple procedure) for idiopathic ERM with a toric IOL.


Eligibility Criteria:
Inclusion Criteria:

* Preoperative corneal cylinder of more than 0.75 diopter
* Symptomatic idiopathic epiretinal membrane
* Symptomatic cataract

Exclusion Criteria:

* Severe media opacity other cataract
* Eyes with other retinal disease, such as diabetic retinopathy, retinal vein occlusion, rhegmatogenous retinal detachment
Effects of Green Tea Consumption on Homocysteine Metabolism and Cognitive Dysfunction

Green tea contains catechins and theanine as major ingredients and has been reported to have various beneficial influences on human health. It is reported that the drinking green tea is inversely associated with serum homocysteine level in elderly. However the effect of green tea consumption on cognitive dysfunction is not clinically clarified. The purpose of this study is to investigate the effects of green tea consumption on homocysteine metabolism and cognitive dysfunction in elderly with impaired cognitive function.

Elderly people with impaired cognitive function go on increasing year by year with the coming aged society. Among them, the Alzheimer disease is a major cause of the illness, which is progressively worse, has no fundamental curable therapy, and induces the burdens of caregivers as well as the health insurance and national budget. Recently, homocysteine metabolism is reported to be related to atherosclerosis in aging, and draw attention as the etiology of cognitive dysfunction in elderly.

Green tea contains catechins and theanine as main ingredients. These components are reported to have anti-atherogenic action and effect on improving cognitive dysfunction. However, clinical evidence for homocysteine metabolism and cognitive dysfunction has not been clarified. Therefore, in this study, the investigators attempted to investigate the effects of green tea consumption on homocysteine metabolism and cognitive dysfunction in elderly with impaired cognitive function.

Eligibility Criteria:
Inclusion Criteria:

* Obtained written informed consent before participation
* Possible to consume green tea powder
* Possessing cognitive dysfunction; MMSE score less than 30
* Possible not to take any supplement possessing anti-oxidizing effect; i.e., vitamin A, C, E, β-carotene

Exclusion Criteria:

* Possessing allergy to green tea
* Possessing severe cardiac, respiratory, renal, or hepatic dysfunction
* Possessing severe anemia
* Diagnosed as inadequate to participate in the study by doctor
Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children

The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a topical anesthetic agent. Our hypothesis is: A needle-free jet-injection system (J-Tip) with 1% lidocaine will provide local anesthesia that is comparable to that of a topical anesthetic agent (EMLA cream) when performing lumbar punctures in children.

Lumbar punctures are a common procedure performed in children in the emergency department. In febrile infants they are frequently performed as part of a sepsis evaluation, and in older children they are used in the evaluation of possible meningitis, new seizures, altered mental status and other neurologic emergencies.

Several studies in the pediatric emergency medicine literature have found a positive association between lumbar puncture success and the use of local anesthesia in infant lumbar punctures. Despite this data, studies have shown that 70-76% of lumbar punctures in the emergency department are performed without any form of pain management, with up to 95% of infants receiving no form of pain management. Common reasoning for providers to forgo pain management include the time for topical anesthetics to be effective (30-45 minutes), the pain already associated with injectable lidocaine, and obscuring of anatomic landmarks with injectable lidocaine.

A recent development in pain management for pediatric procedures is the use of needle-free jet injection of lidocaine. One such device is the J-Tip, which uses a compressed carbon dioxide (CO2) cartridge to deliver medication to the subcutaneous tissues to a depth of 5-8 mm in 0.2 seconds. It has been shown to be largely pain-free for children. Multiple studies have shown it to be effective in reducing pain associated with peripheral IV placement in children. The J-Tip has recently been approved for peripheral IV starts in the Children's Hospital Colorado emergency department.

Some hospitals anecdotally report using the device for lumbar punctures, but to date no randomized studies have evaluated its effectiveness in pain management compared to other methods. Our study aims to evaluate the efficacy of the J-Tip in lumbar punctures. It offers the advantage of providing much faster anesthesia compared to topical creams, yet does not require the initial skin puncture of injectable lidocaine. If a rapid form of local anesthesia is available, it may increase the overall use of local anesthesia and improve pain management in the pediatric population.

Eligibility Criteria:
Inclusion Criteria:

* age ≤4 months or 4-18 years
* ability to report VAS for patients 4-18 years
* require lumbar puncture as part of their clinical care

Exclusion Criteria:

* ages 5-47 months
* developmental delay or inability to complete VAS in older patients
* allergy to lidocaine
* requirement of sedation for procedure
* pre-procedural analgesia treatment except for nonsteroidal anti-inflammatory drugs and acetaminophen.
Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using the Eye Tracker and Retest Function of Spectralis® SD-OCT in Glaucomatous Eyes and Healthy Controls

PURPOSE. To evaluate the impact of self-acting eyetracking and retest software on the reproducibility of retinal nerve fiber layer (RNFL) thickness measurements in glaucoma patients and healthy control subjects using Spectralis® SD-OCT.

METHODS. RNFL thickness was measured in 56 normal and 47 glaucomatous eyes by one operator within one session with a brief rest between measurements. Three measurements were taken with the eye-tracker and retest function, and three were taken without this function, alternating between measurement methods.

* Trial with medical device


Eligibility Criteria:
Inclusion criteria:

* Visual acuity of more or equal to 0.5 Snellen, refractive error less than ±5.00 diopters (D) spheric and ±3.00 D cylindrical and no history of ocular trauma or of any other severe ocular disease (particularly diseases affecting the optic nerve or surgery other than uncomplicated cataract surgery).
* Additional inclusion criteria for the glaucoma group were a diagnosis of primary open angle glaucoma (POAG) or PEX-glaucoma.

Exclusion criteria:

* Exclusion criteria for the control group were history of glaucoma or intraocular pressure beyond 21 mmHg and optic disc cupping of more than 0.6
Effect of Myomectomy for Intramural Myoma on Fertility Outcomes in Infertile Women

The aim of this study is to evaluate the effect of myomectomy for intramural myomas on the fertility outcomes in infertile women.

All women participating in the study will be randomly allocated into two groups; myomectomy group and conservative management group. Women in the myomectomy group will be subjected to laparotomy to remove the myomas while women in the conservative management group will not be subjected to surgery. Women in the myomectomy group will be asked to abstain from having sexual intercourse (or use a barrier contraception method) for 3 months after surgery then to start having regular fertility-oriented intercourse after that. Women in the conservative management group will be asked to immediately start having regular fertility-oriented intercourse. Women in both groups will be monitored form the time of starting regular intercourse and for one year for occurrence of clinical pregnancy.

Eligibility Criteria:
Inclusion Criteria:

* Infertility for at least one year.
* Presence of intramural myoma.
* Absence of any other cause of infertility as revealed by basic infertility work up including laparoscopy.

Exclusion Criteria:

* Age is \< 20 or \> 33 years.
* Symptomatic fibroid causing pelviabdominal swelling.
* Presence of \> 2 myomas.
* Presence of a coexisting another type of myoma other than intramural myoma (e.g. submucosal, subserosal, cervical or ligamentary myoma).
* Presence of any other cause of infertility.
Prediction of Cardiac Instability in Intensive Care

A large number of different organ functions are recorded in real time for patients who are monitored in an intensive care unit. On the one hand, the measured values collected in this way are used for continuous monitoring of vital parameters, but they are also evaluated several times a day in order to be able to make decisions regarding further diagnostics and therapy. In the first case, threshold values can be defined, and if these are exceeded or fallen short of, the treatment team is automatically alerted. If these limits are set too liberally, then the alert will only indicate an acute risk to the patient, where extensive pathophysiological changes have already occurred. If the limits are chosen too restrictively, then there are frequent false alarms, since the limits are exceeded in most cases due to natural fluctuation, without this having any pathological value. The consequence is a so-called "alarm fatigue", which in the worst case leads to ignoring correct alarms and thus endangers the patients. By design, all of these readings only show the status quo of a patient. It is the task of the treatment team to predict from the course of these readings whether a threatening situation is developing for the patient.

For daily clinical practice, it would be better if dangerous changes in vital signs could be predicted. In this case, it would be possible to intervene therapeutically not only when a dangerous situation has arisen, but to try to avert this situation through adequate measures by changing the therapy strategy. In such a case, the treatment team would no longer be confronted with emergency alarms, but could counteract an impending deterioration with a long lead time.

The first approaches for detecting a drop in blood pressure, for example, which are based on simple models, are already in clinical use.


Eligibility Criteria:
Inclusion Criteria:

* All adult patients that have been treated at the intensive care units of the Kepler University Hospital, Linz, Austria between 2018-03-01 and 2020-10-31.

Exclusion Criteria:

* None.
Therapeutic Strategies During Exposure to Pain in an Experimental Design

The goal of the present study is to compare different therapeutic strategies (according to habituation model vs. according to the inhibitory learning approach) during exposure to thermal pain in an experimental design.

Exposure therapy is effective for the treatment of individuals with chronic pain and high levels of fear-avoidance. Nevertheless, mechanisms of change for exposure treatment are not sufficiently investigated. According to the habituation model, the activation of a fear structure leads to a habituation of the initial physical response. Therefore, the therapeutic recommendation is to focus on the reduction of fear during exposure sessions. According to the inhibitory learning approach, however, exposure experiences compete with the original US-CS fear association. Therefore, the therapist should maximize the violation of negative expectancies. The present study intends to compare both strategies during the exposure to pain in an experimental design.

Eligibility Criteria:
Inclusion Criteria:

* female gender
* sufficient knowledge of German language

Exclusion Criteria:

* chronic and acute pain conditions
* Raynaud's disease
* high blood pressure
* neuropathy, coronary diseases
* diabetes, current alcohol
* drug or pain-medication (last 24hours)
Trauma Registration at St. Olavs Hospital 2000-2003

St. Olavs Hospital is a trauma referral center in the region of Midtnorge. Admitting trauma patients locally and those referred from hospitals in Nord-Trøndelag, Sør-Trøndelag and Møre-Romsdal.An active trauma team was defined in 1992, but it's work has not been evaluated earlier. Prospective studies of these patients were established 1st of January 2004 at St. Olavs Hospital.

This mapping is a observational retrospective study of trauma patients admitted to St.Olavs Hospital from 2000 until 2003. Patient journals (electronic and paper), autopsy reports and the emergency medical respons systems (AMK) database have been reviwed. We are reviewing the local traumaepidemiology, traumateam performance, mechanisms of injury and the potenially avoidable deaths in trauma.

Eligibility Criteria:
Inclusion Criteria:

* Trauma team activation
* Motor vehicle crash with ejection
* Pedal cyclist, motorcyclist or pedestrian hit by vehicle \>30 km/h
* Fall \> 5 meters
* Fatality in same vehicle
* Interhospital trauma transfer within 24 hrs
* Injury to two or more body regions
* Fracture to two or more long bones
* Spinal cord injury
* Amputation of a limb
* Penetrating injury to head, neck, torso or proximal limb

Exclusion Criteria:

* Burns
* Strangulations
Long Term Results of the Use of Oxybutynin for the Treatment of Hyperhidrosis

Evaluate the long term efficacy and side effects of oxybutynin in the treatment of hyperhidrosis.

This retrospective study aims to evaluate the medical charts of patients who were treated with oxybutynin for at least six months for primary hyperhidrosis. The investigators variables of interest are: (1) quality of life before pharmacological therapy and after six weeks, (2)self-perception of improvement in hyperhidrosis after six weeks of treatment and on last visit (whenever this occur, as long as this happens after six months), (3) side effects related to drug use.

Eligibility Criteria:
Inclusion Criteria:

* Primary hyperhidrosis
* At least 180 days of treatment with oxybutynin

Exclusion Criteria:

* Incomplete medical chart
* Patients with glaucoma