cyrilzakka/clinical-trials huggingface dataset:
Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults

The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.

This hypothesis will be tested by assessing the effect of TRE (not more than 10hr eating window each day for 6 months) in healthy adults (≥21 years of age). The group of subjects enrolled into TRE arm will be compared to control group. All participants will be randomized into either arm of the study.

Eligibility Criteria:
Inclusion Criteria:

-Healthy adults ≥21 years of age

Exclusion Criteria:

-Inability to read or write in English
Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial.

In this double blind, randomized placebo controlled trial we aim to determine the efficacy of simvastatin as an add-on treatment for treatment resistant depression. We will recruit 150 people with treatment-resistant depression with the aim of determining whether the addition of simvastatin (20mg daily) to treatment as usual (TAU) for 12 weeks leads to an improvement in depressive symptom compared with placebo added to TAU.


Eligibility Criteria:
Inclusion Criteria:

* DSM-5 current major depressive episode
* Must currently be on an antidepressant and must have had a non-response to \>2 oral antidepressant treatments in the current episode (including the one they are currently taking).
* Capacity to give informed consent
* Willing to use adequate contraception
* Give written informed consent

Exclusion Criteria:

* Primary psychotic or bipolar disorder
* History of intolerance to statins or presence of any contraindication to statins
* Presence of any serious medical condition or neurological problem
* Presence of autoimmune or inflammatory disorder
* Alcohol or drug dependence
* Active suicidal ideation
* Pregnant or breast-feeding.
Determinants on Rocuronium Dose for Deep Block in Bariatric Surgery

Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade in bariatric surgery.

Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20B). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade in bariatric surgery.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo bariatric surgery

Exclusion Criteria:

* kidney disease (GFR\<60)
* allergy to study drugs
* decline participation
* side effect of propofol and remifentanil
* when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears
Efficacy and Pharmacokinetics of Meropenem in Severe Septic Patients

The experimental and control group were used different administration of Meropenem through monitoring the Meropenem plasma concentration and clinical data

This study is a prospective, randomized controlled trial, which the subjects were severe sepstic patients for selecting Meropenem as antimicrobial drugs. The experimental and control group were used different administration of Meropenem through monitoring the Meropenem plasma concentration and clinical data, eventually demonstrate the effecacy and safety of Meropenem in patients with severe infection and optimize the best clinical practice for antimicrobial agents.

Eligibility Criteria:
Inclusion Criteria:

1. Inpatients, whose informed consent has been obtained;
2. Clinical diagnosis of Sepsis

Exclusion Criteria:

1. Pregnancy or lactation;
2. Treated with other carbapenems;
3. Cannot be evaluated for efficacy and safety result from lack of clinical and laboratory parameter for Infection assessment;
4. Allergy to meropenem or other β-lactams, or the history of allergy;
5. Resistant to meropenem according to the antimicrobial susceptibility test;
6. Epilepsy or history of epilepsy;
7. History of seizures;
8. Combined medicine with sodium valproate;
9. Combined medicine with anti-MRSA, anti-fungal drugs;
10. with severe liver or renal dysfunction;
11. Terminal cancer;
12. Septic shock;
13. APACH II ≥20;
14. Inappropriate to participate in the trial evaluated by investigator.
Effects of External Electrical Stimulating Applied on the Thigh in Men With Urinary Incontinence After Prostatectomy

The aim of this study is to investigate the effects of external electrical stimulation applied on the thigh on urinary symptoms, quality of life, sexual function, perception of subjective improvement and satisfaction in men with urinary incontinence after prostatectomy

The most common complication after prostatectomy surgeries is urinary incontinence. There are conservative and surgical treatment options in post-prostatectomy urinary incontinence. One of the conservative treatment options is electrical stimulation application.

Electrical stimulation with the intraanal probe in men is painful and uncomfortable.

And also there are few studies, demonstrating the effects of electrical stimulation on urinary incontinence after prostatectomy in the literature.

Eligibility Criteria:
Inclusion Criteria:

* Being a male individual with stress or stress-dominant mixed urinary incontinence symptoms after undergoing prostatectomy surgery
* Being over 40 years old
* Not having residual cancerous tissue
* Volunteering to participate in the study

Exclusion Criteria:

* Having serious cardiovascular disease (unstable angina and arrhythmia patients, heart failure patients, etc.)
* Having sensory loss
* Having an ongoing urinary infection
* Having only urgency urinary incontinence
* Using a pacemaker
* Receiving active cancer treatment (radiotherapy, chemotherapy)
* Those who have a problem that interferes with cooperation and understanding
Energetics and Glutamate in Schizophrenia

The goal of this case-control study is to compare brain glutamate, glucose utilisation, lactate production and brain activity in healthy volunteers and people with a diagnosis of schizophrenia.

It investigates the following main questions:

Whether, compared to healthy volunteers, participants with schizophrenia show:

1. reduction in brain glucose utilisation
2. increased brain lactate
3. greater variability in brain glutamate

Participants will be asked to have a screening visit, a MRI brain scan and a PET-MRI brain scan.


Eligibility Criteria:
Inclusion Criteria:

Healthy volunteer group:

1. No history of psychiatric illness, as assessed on the Mini neuropsychiatric Interview (MINI).

Treatment responsive schizophrenia group:

1. Meeting ICD-11 criteria for schizophrenia (F20)
2. Meeting symptomatic consensus criteria for remission, defined as scores of mild or less on items P1, P2, P3, N1, N4, N6, G5 and G9 of the PANSS and no history of symptomatic relapse in the past 6 months.
3. Currently receiving one or more of the following antipsychotic medications: Olanzapine; Risperidone; Quetiapine; Amisulpride; Aripiprazole; Paliperidone.
4. Antipsychotic adherent, defined as having a score of \>=moderate adherence on the Kemp scale.

Treatment-resistant schizophrenia group:

1. Meeting ICD-11 criteria for schizophrenia (F20)
2. Meeting modified consensus criteria for treatment resistance, including history of at least two antipsychotic treatment trials each lasting ≥6 weeks at a dose of ≥400mg chlorpromazine equivalents.
3. Total PANSS total score \> 70
4. Moderate functional impairment (\<60 on the SOFAS)
5. Currently receiving one or more of the following antipsychotic medications: Clozapine; Olanzapine; Risperidone; Quetiapine; Amisulpride; Aripiprazole; Paliperidone.
6. Antipsychotic adherent, defined as having a score of \>=moderate adherence on the Kemp scale.

Exclusion Criteria:

All participants:

1. Pregnancy or breastfeeding
2. Lacking in mental capacity to provide informed consent to study participation.

2. Diabetes or history of taking an antidiabetic medication 3. Presence of contraindication to MRI at 7 Tesla, including metallic or electronic implants and dental wires.

4. Severe claustrophobia prohibiting participation on PET or MRI 5. Body size above the comfortable limits for the MRI scanner. 6. Previous participation in research or clinical procedure/s involving ionising radiation, which, including the current study, would result in total radiation exposure \>=10mSv within 12 months 7. History of head injury resulting in loss of consciousness for \> 5 minutes 8. Meeting ICD-11 criteria for organic mental disorder (F00-F09) 9. Meeting ICD-11 criteria for mental and behavioural disorders due to psychoactive substance use (F10-F19) 10. With exclusion of nicotine or cannabis, meeting ICD-11 criteria for psychoactive substance dependence 11. Participation in clinical trial investigating any pharmacological agent other than a licensed antipsychotic compound in the last month.
To Explore the Protective Effect of SARS-CoV-2 Vaccination on Cancer Patients Infected With SARS-CoV-2

For tumor patients, the virus antibody titer produced by the SARS-CoV-2 vaccine is often lower than that of normal people in a short period of time, but in the long run, it can significantly reduce the infection rate and fatality rate of the new coronavirus, and the adverse reactions are mild and there is no significant difference with normal people. However, there is still no real-world research data in China to prove the protective effect of the SARS-CoV-2 vaccine on patients with tumors infected with the SARS-CoV-2 virus.

To explore the protective effect of SARS-CoV-2 vaccination on cancer patients infected with SARS-CoV-2. Serum samples were collected from cancer patients who had been infected with SARS-CoV-2 and were previously vaccinated or unvaccinated. The SARS-CoV-2 antibodies (IgG and IgM concentrations) were detected by micro-magnetic particle chemiluminescence method, and the differences were compared. The results of this real-world prospective cohort study can be used to guide the vaccination of cancer patients in clinical practice.

Eligibility Criteria:
Inclusion Criteria:

1. age \> 18 years old, regardless of gender;
2. patients with previous or current tumor, regardless of tumor type;
3. have a history or current infection with SARS-CoV-2;
4. The vital signs were stable, without severe pulmonary, heart, liver and other important organ dysfunction;
5. those with good compliance, agreed to participate in this clinical study, receive corresponding treatment, and signed the informed consent.

Exclusion Criteria:

1. Those who do not meet the inclusion criteria or diagnostic criteria, and cannot cooperate with blood sampling and arrangement;
2. patients with severe bleeding disorders such as coagulopathy or essential thrombocytopenia;
3. local skin ulceration affecting blood drawing, severe rash, or infectious diseases;
Evaluation of the Supported Housing System for the Inclusion of People Suffering From Mental Disorders

Access to housing, in the current context of extreme tension in the rental housing market in Paris and throughout the Ile-de-France region, is proving to be extremely complex for people with mental health problems.National and international scientific studies have quantified the problem of homelessness and precarious or inappropriate housing among patients suffering from psychiatric disorders, and show the impact of housing problems on the consumption of psychiatric care.The DÉLAI's mission is to facilitate access to housing for people enrolled in a psychiatric care pathway, with teams from the psychiatric sectors

* Written and oral information provided to the patient by the patient's referring psychiatrist (Investigator of one of the five recruiting sites) during a regular consultation appointment.
* Initial assessment (V inclusion): reminder of the information concerning the research, collection of consent, collection of sociodemographic data, and standardized assessment scales (quality of life, clinical state, level of functioning) + standardized semi-structured interview for the diagnosis of psychiatric disorders + completion by the referring psychiatrist of the data corresponding to the patient's care pathway.
* Then follow-up visit at an annual rate (V1 ... VX), and DLAI exit assessment (V exit) as soon as the patient stops benefiting from the DLAI.

Eligibility Criteria:
Inclusion Criteria:

patient followed for a psychiatric disorder patient benefiting from a DLAI

Exclusion Criteria:

patient not followed for psychiatric disorder patient who refused to participate in the research
HDL Target of CoViD19 ? Analysis on the Caregivers of the Reunion University Hospital

Since December 2019, the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic has spread around the world. The people most exposed to this virus remain the healthcare personnel who are on the front line in the fight against this pandemic. Due to the delayed nature of the pandemic in Reunion island and its insular geographical situation, the study of the voluntary medical personnel will allow the investigators to establish a longitudinal follow-up of the anomalies of the lipidic balance in relation to the exposure to the SARS-Cov virus. 2. During bacterial infections, the lipid profiles are profoundly modified with very significant reductions in plasma cholesterol levels, LDL-C but especially HDL-C whose concentrations are particularly low. Lipid profiles are altered during viral infections, for example, the severity of dengue is inversely correlated with total cholesterol and LDL-C but not with HDL-C levels, according to a recent meta-analysis. The hepatitis C virus circulates in serum linked to lipoproteins rich in triglycerides and HDL can facilitate its entry into cells via Scavenger receptor class B type 1 (SRB1). Likewise, it has been shown that apoA1 can bind to the dengue virus and increase its infectivity by promoting its entry into cells, also via SRB1. At the moment, nothing is known about the lipid profiles in subjects with SARS-CoV-2. The investigator hypothesize that a drop in plasma HDL-C levels and a change in their size during infection could justify future therapeutic approaches aimed at supplementing the subjects most at risk of pulmonary complications. In a model of Pseudomonas aeruginosa pneumonia in mice, investigators have shown that the injection of reconstituted HDL allowed to limit the pulmonary inflammation and the deleterious consequences of the infection. The investigator propose to study not only the lipid profiles in subjects who are infected with SARS-CoV-2 but also the polymorphisms of genes involved in the regulation of lipoprotein levels like that of Cholesterol Ester-Transfer Protein (CETP) depending on the developed forms, symptomatic or not.


Eligibility Criteria:
Inclusion Criteria:

* Caregiver in Reunion island University Hospital Center
* Practicing in a care service possibly exposed to the coronavirus
* Signed Consent

Exclusion Criteria:

* Refusal to participate
* Already infected by Covid19
Vyndaqel Capsules Special Investigation (ATTR-CM)

Secondary Data Collection : To confirm the safety and effectiveness profiles under the actual medical practice of Vyndaqel in Japan. This study is conducted in accordance with the protocol even when Vynmac is used, and information the use of Vynmac during the observation period is also collected.

To comprehend information on the long-term safety (e.g., onset status of adverse reactions), etc. of patients who are treated with Vyndaqel for the treatment of transthyretin amyloid cardiomyopathy. When Vynmac is used, conduct the study to grasp information on safety (e.g., onset status of adverse reactions),etc. during the observation period.

Eligibility Criteria:
Inclusion Criteria:

* Patients administered Vyndaqel for the treatment of ATTR-CM

Exclusion Criteria:

* N/A
Satisfaction With an In-house Developed Nasal Foreign Body Removal Manikin

To overcome the issues regarding training in real persons, using a simulated manikin instead of an actual patient or simulated patient is another option with consideration to the training able to be held at any time periods and no issues about minor or serious complications needed to be concerned with. The aim of this study is to devise a low-cost manikin with a specific design to serve all possible needs of end users but still keep its function as necessary for training.


Eligibility Criteria:
Inclusion Criteria:

* Physicians who hold a MD degree

Exclusion Criteria:

* Not want to complete questionnaires
* No experience in a nasal foreign body removal
BFR Training on Muscle Morphology

This randomized clinical trial study compares high-load eccentric training (HL-Et), sham LL-BFRt, and low-load blood flow restriction (LL-BFRt) in sportsmen. The primary inquiries it seeks to address are:

Is LL-BFR superior to HL-Et and sham LL-BFRt in terms of improving muscle morphology? Is LL-BFR a more effective Patellofemoral Pain Syndrome and ACL injury preventive than HL-Et and sham LL-BFRt?

The three intervention groups that will be randomly assigned to participants are LL-BFRt, sham LL-BFRt, and HL-Et. Participants are expected to carry out:

Participants in LL-BFRt will be required to perform LL eccentric training at 30% of their repetition maximum (RM) and 70% of their artery occlusion pressure (AOP). This training will include stairs, single leg squat, and single leg deadlift.

Participants in HL-Et will be required to perform LL eccentric training at 70% of their maximum number of repetitions (RM).

In order to determine whether muscular morphology and the prevention of Patellofemoral Pain Syndrome and ACL injury improve following the interventions and follow-up, researchers will compare LL-BFRt, sham LL-BFRt, and HL-Et.


Eligibility Criteria:
Inclusion Criteria:

* Being between the ages of 15 and 35
* Play level 1 sports (fight martial arts, basketball, futsal, and soccer) at least twice a week
* Never experienced an Patellofemoral Pain Syndrome or ACL injury before
* Never experienced a grade III sprain or strain
* Consent to participate in the study until its conclusion and provide informed consent.

Exclusion Criteria:

* Having a tumor, cancer, vena thromboembolic disease, obesity, diabetes, hypertension, anemia, and renal failure
* Disabilities or those who are disabled.
Spinal Straightness, Posture And Balance, Physical Performance And Energy Consumption In Individuals With Stroke

Patients diagnosed with ischemic or hemorrhagic stroke who applied to Kırıkkale University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation will be included in the study. The aim of our study is to investigate the relationship between spinal alignment, posture and weight transfer symmetry with balance, physical performance and energy expenditure in stroke patients.

Patients diagnosed with ischemic or hemorrhagic stroke who applied to Kırıkkale University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation will be included in the study. The number of patients to be included in our study will be determined by power analysis.

Sociodemographic information (Age, Gender, Body Mass Index, Dominant Side) of the individuals included in the study will be recorded.

Information about the stroke (cause of stroke, time elapsed since stroke, side of involvement, neglect after stroke, comorbidities, history of falls in the last six months and 1 year, use of assistive devices, etc.) will be recorded.

1. Motor assessment The motor level of the individuals will be assessed according to the Brunnstrom Assessment. Upper and lower extremities will be evaluated separately.
2. Posture assessment Within the scope of the posture assessment of the individuals, Spinal Mouse, a computer-aided device, will be used for spinal alignment, and Postural Symmetry Index and Weight Transfer Symmetry will be calculated.
3. Balance Trunk control will be assessed with the Postural Assessment Scale for Stroke Patients (PASS), standing balance will be assessed with the Minibestest, Functional reach test (FUT) and timed get up and walk test (ZKTY)
4. Physical performance assessment Six-minute walk test and 5 times sit and stand test will be used to evaluate physical performance. In addition, physiologic energy expenditure index will be calculated during the six-minute walk test.

When we examine the literature, there are many separate studies on the alignment of the pelvis after stroke, weight transfer symmetry, postural control and energy consumption of individuals with stroke. However, there is a lack of studies on spinal alignment in stroke patients in general. Therefore, the aim of this study was to investigate the relationship between spinal alignment, posture and weight transfer symmetry with balance, physical performance and energy expenditure in stroke patients.

Eligibility Criteria:
Inclusion Criteria:

* Individuals between the ages of 18-75 years diagnosed with stroke
* Volunteering to participate in the study
* Diagnosis of hemorrhagic or ischemic stroke,
* No collaboration and communication problems
* Can walk with assistive device or independently

Exclusion Criteria:

* Have another neurological, cardiopulmonary or orthopedic problem other than stroke that may affect functionality, ambulation and balance
* Patients who refused to participate in the study and did not give written consent.
* Cooperation and communication problems were determined as
Superomedial Pedicle Versus Inferior Pedicle Techniques in Wise Pattern Reduction Mammaplasty :A Comparison Study

A comparison study between superomedial and Inferior pedicle techniques in wise pattern reduction mammaplasty

To compare complications of both techniques in wise pattern reduction mammaplasty and to correlate between complications and patient mediated factors

Eligibility Criteria:
Inclusion Criteria:

-

Exclusion Criteria:

* previous extensive breast surgery Breast cancer
Statement of Care of Anemia in Delivering Patients at Nord Franche-Comte Hospital

Anemia is a common pregnancy condition that has multiple origins. Its frequency and severity seem to be increasing, despite the existing management recommendations and the awareness of health professionals. The objective of this study is to make a statement of this pathology within our establishment, to evaluate the proportion of patients presenting this pathology and to highlight possible risk factors.


Eligibility Criteria:
Inclusion Criteria:

* \> 18 years
* Delivery at Nord Franche-Comte Hospital
* Delivery ≥ 32 weeks of amenorrhea
* Informed patient and non-opposition of participation

Exclusion Criteria:

* Protected adults (Patients under guardianship, curatorship, safeguard of justice or under family authorization)
* Medical interruption of pregnancy
* Patients with fetal death in utero or neonatal death
* Minor patients
* Premature delivery before 32 weeks