cyrilzakka/clinical-trials huggingface dataset:
Left Lobe Versus Right Lobe in Adult Living Donor Liver Transplantation in Borderline GRWR

a prospective cohort study comparing outcomes of left lobe and right lobe adult living donor liver transplantation


Eligibility Criteria:
Inclusion Criteria:

* GRWR below 1

Exclusion Criteria:

* patients with renal impairment portal vein thrombosis vascular complications
Special Drug Use-results Survey of Duodopa Enteral Solution in Patients With Parkinson's Disease

The purpose of this study is to assess the safety and efficacy of long-term use of Duodopa in patients with Parkinkon's disease in actual usage


Eligibility Criteria:
Inclusion Criteria:

1. Patients with Parkinson's disease using Duodopa for the purpose of improving circadian change (wearing-off phenomenon) of symptoms of Parkinson's disease in which sufficient effect cannot be obtained with existing drug therapy including levodopa-containing drugs.

Exclusion Criteria:

NA
A Comparison of High-flow Nasal Oxygen and Conventional Nasal Cannula in Monitored Anesthesia Care for Endoscopic Submucosal Dissection

Sedation for endoscopic submucosal dissection places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk. The aim of this study is to evaluate the role of high-flow nasal oxygen during endoscopic submucosal dissection. We will compare the incidence of hypoxemia (defined as SpO2 lower than 90%) of conventional nasal oxygen cannula group and that of high-flow humidified oxygen-delivery system group during the procedure.


Eligibility Criteria:
Inclusion Criteria:

* patients who will undergo endoscopic sumucosal dissection under remimazolam-based sedation

Exclusion Criteria:

* dementia or cognitive dysfunction
* altered mental status
* intubated patients or tracheostomy
* pregnancy
* recent history of nasal bleeding
* contraindication for positive pressure ventilation
* patients under oxygen therapy
* illiteracy or foreigner
Comparison of Clomiphene Citrate and Gonadotropins in Ovulation Induction Cycles

The purpose of the present study is to analyse prospectively if highly purified hMG compared with increased dose of clomiphene citrate has different outcomes in folliculogenesis in ovulation induction cycles.


Eligibility Criteria:
Inclusion Criteria:

* \< 39 years old on day of randomisation
* FSH \< 12 (in the early follicular phase)
* Normal ultrasound scan, i.e. presence of both ovaries, without evidence of abnormality within 6 months prior to randomisation.
* Chronic oligo or anovulation (WHO 2)
* BMI between 18 and 31 (both inclusive)

Exclusion Criteria:

* ≥ 39 years old on day of randomisation
Comparative Study Between Delorme Operation With or Without Postanal Repair in Treatment of Complete Rectal Prolapse

The aim of the study is to compare Delorme operation alone or with post anal repair and levatorplasty for treating complete rectal prolapse.consecutive patients who were treated for complete rectal prolapse at the Colorectal Surgery Unit were eligible for the study.The patients were randomized into two groups: Group I: consisted of patients were subjected to delorme operation only. Group II: consisted of patients were subjected to delorme operation with post anal repair and levatorplasty.

Rectal procidentia frequently occurs in older women. Patients usually present with obstructed defecation or fecal incontinence. This study is to compare Delorme operation alone or with post anal repair and levatorplasty for treating complete rectal prolapse. Consecutive patients who were treated for complete rectal prolapse at our Colorectal Surgery Unit were eligible for the study. Exclusion criteria include pregnant female, any patients with previous anal surgery, pudendal nerve neuropathy, anal fistula and sepsis or coagulopathy. All patients underwent clinical evaluation, proctoscopic examination, and sigmoidoscopy. Anorectal physiology studies consisted of anal manometry and measurement of pudendal nerve terminal motor latency (PNTML) to exclude pudendal nerve entrapment syndrome. Patients enrolled in the study were randomized into three groups using the closed envelope method. The envelopes were drawn and opened by a nurse not otherwise engaged in the study in the operating room. The patients were randomized into two groups: Group I: consisted of patients were subjected to delorme operation only. Group II: consisted of patients were subjected to delorme operation with post anal repair and levatorplasty.

Eligibility Criteria:
Inclusion Criteria:

* complete rectal prolapse

Exclusion Criteria:

* pregnant female
* any patients with previous anal surgery
* pudendal nerve neuropathy
* anal fistula and sepsis or coagulopathy
Tofacitinib Ointment For Chronic Plaque Psoriasis

The study is beng done to test if tofacitinib ointment is safe and effective for people with plaque psoriasis. Two dose strengths of tofacitinib ointment (20 mg/g and 10 mg/g) applied once or twice daily are being tested. The safety and effectiveness of tofacitinib ointment used for 12 weeks will be compared to the safety and effectiveness of placebo ointment (vehicle) used for 12 weeks.


Eligibility Criteria:
Inclusion Criteria:

* Have mild, moderate or severe plaque psoriasis (psoriasis vulgaris) for at least 6 months prior to Baseline
* At Baseline, have plaque psoriasis covering 2% to 20% of total body surface area (BSA) on the trunk and limbs (excluding palms, soles, and nails)
* If received certain treatments, should be off treatment for a minimum period of time (washout)

Exclusion Criteria:

* Currently have non-plaque forms of psoriasis or drug-induced psoriasis
* Require treatment with or cannot stop medication(s) prohibited during the study
* Have certain laboratory abnormalities at Baseline
* Current or history of certain infections
* Females who are pregnant, breastfeeding, or are of childbearing potential not using highly effective contraception
Double-blind Trial of Mannitol Cream to Block the Effect of Capsaicin Cream

Capsaicin is a TRPV1 (transient receptor potential vanilloid 1) agonist, causing pain upon application. The investigators wish to determine whether mannitol blocks the effect of capsaicin application. As both cream bases are identical and mannitol addition is the only difference between the creams, if the mannitol cream is more effective in blocking the effect of capsaicin on the TRPV1 (transient receptor potential vanilloid 1) receptor, the investigators will have established that mannitol down-regulates or blocks the TRPV1 (transient receptor potential vanilloid 1) receptor.

Capsaicin cream, which stimulates the TRPV1 (transient receptor potential vanilloid 1) receptor, causing a burning sensation, will be applied to both halves of the upper lip until a burning sensation with 8/10 intensity on an NRS (Visual Analog Scale) scale is experienced or five minutes have elapsed. Following this, the capsaicin cream will be wiped off and 30% mannitol in vehicle cream ( isopropyl palmitate, caprylic capric triglyceride, propylene glycol, ceteareth 20, cetearyl alcohol, glyceryl stearate, polyethylene glycol 100 stearate, dimethicone, octyldodecanol, lecithin, ethylhexyl glycerin and phenoxy ethanol) will be applied to one half of the upper lip, and vehicle cream alone will be applied to the other half. Cream assignment will be randomized and neither the subject nor the person applying the cream will know which half upper lip has which cream. Every minute for 10 minutes, the heat sensation felt in each half upper lip will be measured, using a visual scale from 0 to 10. A repeated measures analysis of variance will compare the NRS (Visual Analog Scale) scores from the 30% mannitol cream, to the NRS (Visual Analog Scale)scores from the vehicle cream. Significance will be accepted if P less than .05.

Eligibility Criteria:
Inclusion Criteria:

* Age between 19 and 80 years

Exclusion Criteria:

* Diet containing capsaicin (Cayenne pepper, capsicum) (spicy foods), more than once a week.
* Meal containing capsaicin (spicy foods) within 5 days prior to the experiment.
* Any lesion, cracking, cold sore or abrasion on the lips
* Inability to tolerate capsaicin containing "spicy foods"
* Wearing lipstick or lip balm on the upper lip
* Inability to fill out an NRS pain scale
* Use of painkilling medication, within 24 hours of the study.
* Allergy to any of the ingredients of the creams, or to mannitol
* History of contact or allergic dermatitis
* Pregnant or nursing women
Orthodontic Treatment Impact on Life Experience of Adolescents With Fixed Orthodontic Appliances

This cross-sectional study aimed to investigate the impact of different fixed orthodontic appliances on the day-to-day life experience of adolescent patients at any stage of their orthodontic treatment. A validated questionnaire was translated and used in the assessment, 364 patients (242 female and 122 male) were recruited, impact on the social and emotional well-being status of the participants was assessed as well as oral health, pain, and discomfort.

This cross-sectional study aimed to evaluate the impact of orthodontic treatment on the daily life experience of adolescents wearing fixed orthodontic appliances. We aimed to assess the impact of different fixed orthodontic appliances in a sample of 364 patients either having labial fixed orthodontic appliances only or combined with palatal anchorage appliances, combined with mini-screws, combined with both palatal anchorage appliances and mini-screws or having fixed retainers. The outcomes were the impact on the patient's social and emotional well-being status and the impact on the patient's oral health, pain, and discomfort. a questionnaire was distributed and the patient was asked to fill it in. The questionnaire is composed of 22 questions with a 3-point scale.

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients
* Patients wearing fixed orthodontic appliances at any stage of treatment (labial fixed appliance only - labial fixed appliance combined with any palatal or lingual appliance - labial fixed appliance combined with mini-screws) or fixed retainers either in the upper arch only, lower arch only, or in both arches.
* Age: 13-18 years old

Exclusion Criteria:

* Patients who refused to participate in the study.
* Patients with cleft lip or palate.
* Illiterate patients.
* Patients who had a complicated medical history.
* Patients with severe skeletal discrepancy undergoing combined orthodontic and orthognathic surgical treatment.
The Influence of Head and Neck Position on Performance of Ambu AuraGainTM in Children

The influence of different head and neck positions on the effectiveness of ventilation with the Ambu AuraGain airway remains unevaluated.

This study aimed to evaluate the influence of different head and neck positions on ventilation with the AuraGain airway.

An AuraGain will be placed in all patients, and mechanical ventilation will be performed using a volume-controlled mode with a tidal volume of 10 ml/kg.

The expiratory tidal volume, peak inspiratory pressure, oropharyngeal leak pressure, and ventilation score will be assessed first for the neutral head position and then for the extended, flexed, and rotated head positions in a random order.


Eligibility Criteria:
Inclusion Criteria:

* Children \< 7 years old who scheduled for general anesthesia using supraglottic airway

Exclusion Criteria:

* Children who require tracheal intubation
* Emergency operation without NPO
* History of C-spine surgery or disease
* History of Esophageal disease or surgery
Capnography Data Collection From Healthy Participants

Capnography is the non-invasive monitoring of the concentration or partial pressure of carbon dioxide (CO2) in the expired respiratory gases; it is thus a non-invasive monitoring technique which allows fast and reliable insight into ventilation, circulation and metabolism. The capnogram is a direct monitor of the inhaled and exhaled concentration or partial pressure of CO2, and an indirect monitor of the CO2 partial pressure in the arterial blood. The purpose of this study is to create a waveform library by collecting CO2 waveform data from healthy volunteers.


Eligibility Criteria:
Inclusion Criteria:

* Consent to participate in the trial by volunteer themself or by their legal guardian

Exclusion Criteria:

* Any individual who does not consent themselves or their legal guardian does not grant consent to participate in the trial
* A medical history of heart disease, lung disease, smoking, hypertension, pregnancy, diabetes or any other illness that excludes the participant from enrolling in the trial in the opinion of the PI
Rosuvastatin Affecting Aortic Valve Endothelium

Recent studies support the hypothesis that aortic stenosis (AS) develops due to atherosclerosis affecting the aortic valve endothelium. The study's aim was to assess Rosuvastatin on the hemodynamic progression and inflammatory markers of AS by treating low-density lipoprotein (LDL) in patients with AS according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) guidelines for one year.

Background: Recent retrospective studies support the hypothesis that statins slow the progression of aortic stenosis. The aim of this study was to assess the effect of Rosuvastatin on hemodynamic progression of aortic stenosis by treating patients with aortic stenosis and elevated LDL-cholesterol for 18 months.

Methods: We performed an open-label, prospective study evaluating 121 consecutive patients with asymptomatic moderate to severe aortic stenosis (AVA≥ 1.0 cm2), (mean age 73.7±8.9 years; 57 men and 64 women), treated with and without Rosuvastatin according to the NCEP-ATPIII guidelines. Echocardiographic, serum lipid, and inflammatory markers were measured at baseline and every 6 months for 18 months.

Eligibility Criteria:
Inclusion Criteria:

* Asymptomatic AS
* Normal ejection fraction
* Elevated LDL \>130 mg/dl

Exclusion Criteria:

* Echocardiographic evidence of rheumatic mitral valve disease,
* Previous statin therapy,
* Congenital heart disease (bicuspid aortic valve),
* Subaortic obstruction,
* Creatinine ≥ 2,0 mg/dl (to avoid the potential confounder of an elevated serum \[CaP04\]),
* Evidence of liver disease,
* Greater than mild aortic regurgitation and previous aortic valve surgery
Effect of Pilates and Kegel Exercises During Pregnancy

Urinary incontinence and fecal incontinence are common health problems in the postpartum period because of their effect on daily life and are likely to reduce quality of life. It is known that the most effective way to protect from UI during pregnancy and the postpartum period is pelvic floor muscle exercise. This study aimed to investigate the effects of Pilates and Kegel exercises applied during pregnancy on the quality of life of urinary and fecal incontinence in the postpartum period.

In this study; the effects of pilates and kegel exercises on urinary and fecal incontinence of pregnant women in the 1st and 3rd months postpartum are investigated and which of the applied pilates and kegel exercises is more effective on urinary and fecal quality of life.67 pregnant women with a mean age of 27.29±3.27 years participated in the study. Pilates exercise group (PEG, n=24), Kegel exercise group (KEG, n=22), and Control group (CG, n=21) were formed with the purposeful method. PEG exercise programs were applied for 8 weeks, 2 days a week, 40 minutes, and KEG for 8 weeks, 4 days a week, 3 sessions per day. The groups were applied the International Incontinence Questionnaire Short Form, Urinary Incontinence Quality of Life Scale, Wexner Continence Assessment Scale, and Fecal Incontinence Quality of Life Scale at 1st. and 3rd. months postpartum

Eligibility Criteria:
Inclucision Criteria

* Being between the ages of 18-38 years,
* Not having a condition that prevents exercise,
* Being in the 3rd trimester of pregnancy,
* Voluntarily accepting to participate in the study, a
* Answering each of the scale items,
* Having a vaginal (normal) birth.

Exclusion Criteria:

* Not being between the ages of 18-38,
* Having a condition that prevents exercise,
* Not being in the 1st and 2nd trimesters of pregnancy,
* Leaving scale items blank, and having a cesarean section.
N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence

The goal of the proposed study is to evaluate the efficacy and safety of N-Acetyl Cysteine (NAC) in combination with naltrexone in methamphetamine dependence.

Forty subjects with DSM-IV methamphetamine dependence will receive 8 weeks of double-blind combination medication (NAC plus naltrexone) or placebo. The hypothesis to be tested is that NAC plus naltrexone will be effective and well tolerated in patients with methamphetamine dependence compared to placebo. The proposed study will provide needed data on the treatment of a public health crisis that currently lacks a clearly effective treatment.

Eligibility Criteria:
Inclusion Criteria:

1. men and women age 18-65
2. current DSM-IV methamphetamine dependence.

Exclusion Criteria:

1. unstable medical illness
2. history of seizures
3. myocardial infarction within 6 months
4. current pregnancy or lactation, or inadequate contraception in women of childbearing potential
5. any thoughts of suicide
6. lifetime history of DSM-IV bipolar disorder type I, dementia, or schizophrenia or any other DSM-IV psychotic disorder
7. previous treatment with N-Acetyl Cysteine or naltrexone
8. treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline
9. abnormal liver function tests at screening
10. diagnosis of asthma
11. current use of opiates.
A Randomized Controlled Trial to Promote Physician-Patient Discussion of Prostate Cancer Screening

Prostate cancer is the most common type of cancer among men. It is also the second leading cause of cancer-related death among men. Two screening tests are available to try to detect prostate cancer early - the digital rectal examination (DRE) and the prostate specific antigen (PSA) blood test. Unfortunately, physicians aren't sure whether or not these two screening tests help save lives, and there's a lot of controversy about how to use them. Recently, a major government committee (the U.S. Preventive Services Task Force) recommended that physicians discuss the risks and potential benefits of prostate cancer screening with their patients, and allow patients to make their own decision.

Because of the controversies, many physicians currently don't discuss prostate cancer with their patients. The problem is that it takes time and effort to have these discussions, and the information is complicated. A lot of patients have trouble understanding it, especially if they have a limited educational background or trouble reading. When patients have difficulty obtaining, understanding, and acting on basic health information, we say that they have "low health literacy." Other researchers have shown that patients with low health literacy don't know as much about cancer screening and are less likely to get screened for various cancers. They also tend to be timid about discussing things with their doctor, and often go along with what the doctor says, rather than taking an active role in the decision making.

In 2003, under IRB approval, we conducted a study with 2 goals: 1) to encourage patients to talk to their doctor about prostate cancer screening, and 2) to learn more about the impact of low health literacy on these conversations. To promote conversation, we used two handouts, given to patients in the waiting room before they saw the doctor. The first was a patient education handout about prostate cancer screening, written in very simple terms with useful illustrations. The second was a handout that simply encouraged patients to talk to their doctor about prostate cancer. Patients got one of the two handouts, or a nutritional handout that served as a control. After they saw their doctor, a research assistant briefly interviewed the patient to find out whether or not prostate cancer screening was discussed. We also measured the patients' health literacy skills, and asked a few other questions about their decision to get screened for prostate cancer.


Eligibility Criteria:
Inclusion Criteria:

* Male
* Age 45-70

Exclusion Criteria:

* Unable to communicate in English
* Too ill
* In police custody
* Visual acuity worse than 20/60
* History of prostate cancer
* Lack of cooperation
* Overt psychiatric illnesses
Hallux Valgus Correction Using the Metal Screw or the Human Allogeneic Cortical Bone Screw (Shark Screw).

The goal of this clinical trial is to compare the treatment of Hallux Valgus using the conventional method (metal screw) with the new method (human allogeneic cortical bone screw (Shark Screw®) in adult patients with confirmed Hallux Valgus.

The main questions it aims to answer are:

Can the new method obtain comparable results as the conventional method in regard to union rate and time to union? Are the number of complications lower with the new method? Participants will be operated either with the metal screw or with the Shark Screw®. The assignment to the groups is randomized.

The planned prospective study will investigate whether the use of the human allogenic cortical bone screw (Shark Screw® leads to comparable results in the union rate and the prevention of recurrences as with metal screws. Furthermore, it will be investigated whether rotational stability is possible with the bone screw. The measurement of the HVA angle and the IMA angle should provide information on whether the correction is stable over time. A comparison of the AOFAS forefoot score before and after the operation for both methods is a further measure to check whether the human allogenic cortical bone screw can deliver similar results.

Initial studies on the use of the allogenic bone screw in hand and foot surgery show particularly good integration behavior of the human allogenic cortical bone screw . A retrospective study by Hanslik-Schnabel et al has shown initial positive results in the treatment of hallux rigidus. In addition, a gait analysis is performed pre- and postoperatively to provide information on possible differences between the two groups in the context of 3D gait analysis/pedobarography and is also matched with another healthy cohort.

At the preoperative time point and after 12 and 24 months, a 3D gait analysis with a foot model is conducted to record the joint kinematics and kinetics. In the study by Canseco et al. , the proximal gait pattern changes remained unchanged. Hwang reported hyper-external rotation in the subtalar joint, excessive eversion in the subtalar joint, and lack of movement in the hallux MP joint in the terminal standing phase.

Eligibility Criteria:
Inclusion Criteria:

* between 18 and 85
* confirmed Hallux Valgus

Exclusion Criteria:

* \<18 years and \>85 years
* Known underlying oncological disease
* Pregnant women or breastfeeding mothers
* Alcohol and drug abuse
* Foreseeable compliance problems
* Foreseeable loss of responsibility as a study doctor
* Neoplastic diseases
* Active osteomyelitis
* Ulcerations in the area of the skin of the surgical site
* Immunosuppressive medication that cannot be discontinued