cyrilzakka/clinical-trials huggingface dataset:
Cognitive Cueing and Video Intervention for Gait in Parkinson's Disease

The goal of this clinical trial is to learn if cognitive cueing (eg., prompting individuals to think about taking big-long steps while walking), either as a stand- alone intervention or combined with a personalized gait training video, can improve gait (walking), mobility, and balance confidence for individuals with Parkinson's Disease. The main questions it aims to answer are:

1. Does focusing on cognitive cues while walking improve gait, mobility, and balance confidence for individuals with Parkinson's Disease?
2. Does incorporating a personalized gait training video alongside cognitive cueing lead to amplified improvements in gait, mobility, and balance confidence for individuals with Parkinson's Disease?

Researchers will compare how gait, mobility, balance confidence and quality of life change over time for participants when they practice walking with and without a cognitive cue alone, and when they practice with using a personalized gait training video.

The researchers are also interested in how participation in this trial will affect quality of life and conscious attention to gait.

Participants will

* Complete walking trials on an instrumented mat that records data on their walking ability. These trials will be undertaken without a cognitive cue and while participants mentally rehearse a series of 3 cognitive cues (Take big long steps; Walk heel-toe; Stand up straight).
* Be informed about which of the 3 cues best improved their walking and will receive a personalized gait training video for at home practice.
* Complete online surveys that ask questions about their Parkinson's Disease, mobility, balance confidence quality of life and conscious attention to gait.
* Visit the research facility 3 to 4 times during the study to have their gait (walking), mobility, balance confidence, quality of life and conscious attention to gait assessed and reassessed.
* Practice both with and without their personalized video at home and keep a diary to record their practice sessions
* Participate in a brief interview to discuss their experiences with the training and their perceptions of the effectiveness of cognitive cues and video-recorded feedback


Eligibility Criteria:
Inclusion Criteria:

* Be diagnosed with Parkinson's Disease
* Be fluent in English
* Be able to walk independently and without a walking aid for at least 10 minutes
* Have no other cognitive or neurological impairments (e.g., brain tumours, recent concussion, stroke, brain injury)

Exclusion Criteria:

* Deep Brain Stimulation (DBS) implant
* Standardized Mini Mental State Examination (SMMSE) score less than 24
Study Evaluating ERB-041 in Endometriosis in Reproductive-Age Women

The purpose of this investigational study is to determine if a study medication is safe and effective in reducing the symptoms associated with endometriosis; if the study medication reduces the need for pain medication for endometriosis symptoms; and if the study medication improves a participant's ability to carry out daily activities. Qualified participants will receive no cost treatment, which may include study-related examinations, diagnostic procedures including a Pap smear, laboratory testing, and a mammogram (aged 40-45). Qualified participants will also receive study medication at no cost. As a participant, the study volunteer may also experience the satisfaction of knowing she is helping the advancement of women's health care.


Eligibility Criteria:
Inclusion Criteria:

* Surgical diagnosis of endometriosis within 5 years
* Not pregnant and not lactating
* Willing to use non-hormonal contraception, history of regular menstrual cycles

Exclusion Criteria:

* Hysterectomy, surgical treatment for endometriosis within 3 months
* Certain medications for the treatment of endometriosis
* Previous history of a malignancy
* Abnormalities on physical or gyn exams and abnormal lab tests
Evaluation of the 1-year Prognosis of Patients Under Veno-arterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock With Blood Transfusion Requirement

The primary objective of this work is to study the 1-year prognosis of patients who received Veno-arterial extracorporeal membrane oxygenation for cardiogenic shock with the need for blood transfusion. Secondary objectives are to determine whether the transfusion strategy used (liberal or restrictive) still has an impact on overall mortality. We will also determine the factors associated with overall in-hospital mortality and look at the impact of transfusion in relation to the risk of hemolysis on the consequences in the occurrence of long-term chronic renal failure.

The study of the prognostic impact of blood transfusion at 1 year in patients assisted by Veno-arterial extracorporeal membrane oxygenation in the context of cardiogenic shock would provide objective answers and optimize the decision to set up this assistance with regard to the possible long-term consequences. This decision currently remains at the discretion of the expert teams managing these patients.

The inclusion of patients in a state of cardiogenic shock under Veno-arterial extracorporeal membrane oxygenation with the need for transfusion, will therefore allow the elaboration of a multicentric observational study interested in the prognosis at 1 year of patients under VA ECMO according to the adopted transfusion threshold.

Eligibility Criteria:
Inclusion Criteria:

* Patient of legal age (\> 18 years) at the time of data collection.
* Hospitalization in intensive care unit
* Cardiogenic shock of medical or surgical etiology according to the SCAI definition (stage B to E)
* Need for cardio-circulatory assistance such as Veno-arterial extracorporeal membrane oxygenation for at least 24 hours

Exclusion Criteria:

* - Age \< 18 years
* In-hospital and out-of-hospital cardiac arrest.
* Veno-arterial extracorporeal membrane oxygenation set up at a center other than the study centers.
* Veno-arterial extracorporeal membrane oxygenation set up for less than 24 hours
* Death within 24 hours
TMJ Dysfunction: Effects on Proprioception, Pain, and Body Awareness

The term "temporomandibular joint dysfunction" (TMJ dysfunction) refers to a range of anatomical and functional problems, with or without clinical signs and symptoms, that affect the TMJ and/or the chewing muscles. It is more frequent in women and young people ages between 20 and 40. Its frequency ranges from 28% to 88%. The term "temporomandibular joint dysfunction" (TMJ dysfunction) refers to a range of anatomical and functional problems, with or without clinical signs and symptoms, that affect the TMJ and/or the chewing muscles. It is more frequent in women and young people ages between 20 and 40. Its frequency ranges from 28% to 88%. This condition is frequently disregarded because of inadequate diagnosis . Additionally, TMJ dysfunction can particularly emerge in the early stages without the presence of pain. Due to the insidious onset of the disease, especially in the early stages, other TMJ-related factors, in addition to pain-related parameters, need to be considered.Therefore, the aim of the study is to investigate the effect of TME disorder on proprioception, body awareness, and pain-related parameters including pain threshold, pain tolerance, and temporal summation in young adults.

"In the study, young adults aged 18-25 will be included, with TMJ dysfunction being measured using the Fonseca Amnestic Index. Based on Fonseca scores, two groups will be formed: those scoring over 20 will be labeled 'with TMJ dysfunction,' while the others will be classified as 'without TMJ dysfunction.' Proprioception will be assessed both through self-reports using the Fremantle Neck Awareness Questionnaire and via joint position sense measured by a CROM device. Body awareness will also be evaluated using the Body Awareness Questionnaire. Pain assessment, including pain threshold, tolerance, and temporal summation, will be conducted using a pressure algometer. The 'pain threshold' will refer to the point at which a person first feels pain, 'pain tolerance' will be the last point that a person can tolerate, and 'temporal summation' will be the pain sensation evaluated after 10 repetitions of the pain threshold.

Eligibility Criteria:
Inclusion Criteria:

\*Being between 18-25 years old

Exclusion Criteria:

* History of cervical spine injuries or disorders
* Chronic pain conditions or diagnosed musculoskeletal disorders
* Previous neck or spine surgeries
* Neurological or psychiatric conditions affecting proprioception or pain perception
* Use of medications influencing pain sensitivity or proprioception
* Pregnancy
Aerobic Exercises for Multiple Sclerosis

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) .It is the most common neurological disorders affecting young adults.Multiple sclerosis is an autoimmune disease that results in progressive neural degeneration. Cytokines play an important role in the pathogenesis and treatment of MS.

This research aims to evaluate the effect of aerobic exercises on the immune system anti-inflammatory (IL-10) and pro inflammatory (IL-17) cytokines and its consequences on the functional status in the Multiple Sclerosis patients.

Aerobic exercises are a term to describe planned, structured and repetitive physical activity undertaken over a prolonged period to maintain or improve physical fitness and functional capacity .

Eligibility Criteria:
Inclusion Criteria:

age ranged from 25 to 45 years. All the patients were remitting relapsing MS according to (revised McDonald criteria.

Duration of MS disease was one to two years before starting of the study. Last attack occurred three months ago. All patients were able to ambulate

Exclusion Criteria:

Patients with other neurological deficits , patient with significant orthopedic abnormalities for both lower limbs, patient with contracture , patient with deformities, pregnant females
Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population

Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal. Several psychotropic drugs are associated with an increased risk of QT prolongation, which is why in clinical practice a baseline ECG is performed before a psychotropic drug is prescribed. However, there are no validated protocols establishing when to repeat this examination or describing clinical events when this examination should be repeated in clinical follow-up.

The study aims to investigate the incidence of QTc prolongation events as a side effect of chronic psychotropic drug administration. For this purpose, ECGs will be recorded and confounding factors of patients at the beginning of psychotropic therapy and after 3, 6 and 12 months will be analyzed.


Eligibility Criteria:
Inclusion Criteria:

* Admitted to psychiatry ward
* Starting a psychotropic drug acting on QT interval

Exclusion Criteria:

* Age \>18aa
* History of administration of drug acting on QT interval in the 3 months prior
Tobacco Zero: Interactive Tobacco Education for Teens

There have been a number of tobacco prevention programs developed and tested in the past few years, and some of the comprehensive programs have been promoted by the Office on Smoking and Health at the Centers for Disease Control (CDC). However, the use of these programs and integration into school-based curriculum has been lacking due to a number of factors. We are proposing to develop an interactive computer-based program for tobacco prevention aimed at middle school students. The CD-ROM is designed to be an adjunct to the existing health education curriculum provided for 6th through 8th grade students.

The CD-ROM is based upon our Phase I prototype program entitled Tobacco World in which students are presented with a video arcade interface that offers them random access to several game-like activities in which they learn about tobacco and the negative health effects associated with tobacco use. We will expand the menu of options to include more complex activities and entertaining games.

The Phase II program will deliver engaging media to educate students about the risks of tobacco and peer and industry influences on their decisions regarding tobacco. Games and activities will be designed to act on mechanisms shown to be effective in decreasing intentions to use tobacco through changing attitudes, social images, beliefs about short and long term physical consequences, perceptions of peers' social images, subjective norms, and perceived behavioral control. We will test individual components of the program with middle school students for effectiveness in changing mediating variables related to initiation and use of tobacco.

The final program will be evaluated in a randomized trial where middle schools in Oregon and New York will be assigned to either an established tobacco prevention curriculum, or to the usual tobacco curriculum plus the Tobacco World program. Students will be assessed at pre-, post- and 6-month follow-up to evaluate the impact of program use on intentions, and actual tobacco use.

Eligibility Criteria:
Inclusion Criteria:

* Middle school students in 6th or 7th or 8th grade in Oregon and New York City whose parents have consented to have their child participate;
* Middle school health education teachers in Oregon and New York City

Exclusion Criteria:

* Students unable to understand English.
Evaluating a Novel Medication Device for Methadone Dosing

This study will evaluate whether a commercially available, secure, electronic pill box is a feasible, acceptable, and satisfactory method to manage take-home dosing of methadone for both methadone clinic patients and staff members.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or older
* Receiving methadone for the treatment of opioid use disorder for at least 90 days and having been on the same methadone dose for at least 30 days
* Have previously received a take-home dose of methadone as part of routine care
* Be willing to comply with the study schedule
* Be a methadone patient in the clinic within which this study is being conducted

Exclusion Criteria:

* Pregnancy
* Presence of an acute medical problems that requires immediate or intense medical management
* Presence of serious or unstable mental illness that interferes with study procedures
* Planning to leave methadone treatment within the next 12 weeks
* Being maintained on a dose of methadone that is less than 10mg or more than 100mg
* Currently receiving split doses of methadone as part of routine care
A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06372865 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56-75 Years (Group 2)

The purpose of this study is to investigate safety, toleration and time course of plasma concentration of multiple oral doses of PF-06372865 for 14 days in healthy subjects of two age groups, 18-55 years (Group 1) and 56-75 years (Group 2).


Eligibility Criteria:
Inclusion Criteria:

* For Group 1 specific: Healthy male and/or female subjects of non-childbearing potential between the ages of 18 and 55 years, inclusive at Screening. Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead ECG and clinical laboratory.
* For Group 2 specific: Male and/or female subjects of non-childbearing potential between the ages of 56 and 75 years, inclusive at Screening. Subjects must be in reasonably good health as determined by the Investigator based on a detailed medical history, full physical examination (including blood pressure and pulse rate measurement), 12-lead ECG and clinical laboratory tests. Subjects with mild, chronic, stable disease (eg, osteoarthritis) may be enrolled if deemed medically prudent by the Investigator. At least 50% of the subjects enrolled in these cohorts must be 60 years of age and above at Screening.
* For Group 2 specific: Subjects taking daily prescription or non-prescription medications for management of acceptable chronic medical conditions must be on a stable dose of these, as defined by non change in dose for the 3 months prior to the first dose of study medication and no planned changes during the conduct of the study.

Exclusion Criteria:

* For Group 1 specific: Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).
* For Group 2 specific : Evidence or history of unstable disease or moderate to severe conditions which would, in the Investigator's opinion, interfere with the study evaluations or impact on the safety of participating subjects, such as orthostatic hypotension.
* Subjects with history of sleep apnea
* Any condition possibly affecting drug absorption (eg, gastrectomy).
Post-surgical Pain Assessment in Children: Roles of Skin Conductance and Genomics

Pain assessment in infants and toddlers is quite challenging since children in these populations are nonverbal or preverbal and cannot describe the presence and severity of pain that they perceive. Over the last decade, advances in the field have included the development of behavioral scoring systems for the assessment of acute pain . However, although they have been validated, these commonly used methods of pain assessment are largely subjective and rely on a highly trained observer. An objective continuous measure of pain would be an important addition to standard behavioral painscores which require nurses to monitor the child's behavioral responses.

After standard general anesthetic mask induction, 0.5 ml of blood will be drawn for genetic analysis when the intravenous catheter is sited. A member of the research team will manually transport an appropriately-labeled blood collection tube to the Department of Anesthesiology Perioperative Genomics Laboratory for storage and further preparation for genetic analysis. The samples will be stored until the investigators have enough to process. The results will be stored in a secure database. The surgical procedure, anesthesia technique, intraoperative analgesia treatment and initial postoperative analgesia treatment will be standardized.Upon arrival in the Post-Anesthesia Care Unit(PACU), the child will be connected to standard monitors as per standard of care. Pain scores will be recorded on a scale of 0-10 (FLACC, Face, legs,activity, cry, consolability scale) scale. A member of the research team will apply the skin conductance (SC) monitor on the child's hand or foot.This will be used to measure SC values that will be saved on a laptop computer and the SC data will be analyzed off-line.

Eligibility Criteria:
Inclusion Criteria:

* Children 0 - 3 years of age inclusive
* Presenting for palatal repair (palatoplasty)
* American Society of Anesthesiologists (ASA) physical status of 1 or 2

Exclusion Criteria:

* Children \> 3 years of age
* On chronic pain treatment
* Pre-operative use of analgesics
* Allergies to any anesthetics or analgesia products
* Known obstructive sleep apnea
* Diagnosis of Cystic fibrosis
* American Society of Anesthesiologists (ASA) physical status ≥ 3
Evaluation of FLEXOFYTOL® Versus PLACEBO

This study is a prospective, randomized, double-blind, placebo-controlled with 3 parallel-groups and multicenter trial in patients suffering from knee OA (osteoarthrosis).

A first exploratory non comparative study (TILFLEXY002, NCT01909037, Henrotin et al., 2014 BMC Complementary and Alternative Medicine) evaluated the efficacy of FLEXOFYTOL® at the dose of 2x3 caps/day, during a 3-month period, in 22 patients suffering from knee OA, on the serum levels of cartilage-specific and inflammatory biomarkers, on the evaluation of pain and on the global patient assessment of disease activity.

This study demonstrated a statistically significant decrease of sColl2-1 cartilage specific biomarker, an early decrease of the ultrasensitive C-reactive protein (CRP), an improvement of the global assessment of the disease by the patient as well as a good tolerance and compliance for the treatment. Results of this exploratory study are encouraging and justify the setup of a randomized, placebo-controlled double blind and dose-ranging trial.

150 patients suffering from symptomatic knee OA will be randomized in 3 parallel groups (50 patients per group). Each patient will be enrolled in the study for 6 months including 4 visits: Inclusion visit (T0), follow-up visits after 1 month (T1), 3 months (T3) and 6 months (T6).

A. Primary objective

- Evaluate the efficacy of two different dosages of FLEXOFYTOL® versus PLACEBO on arthritis related biomarker coll2-1 and on patient assessment of disease activity in patients suffering from knee OA after a 3 months treatment

B. Secondary objectives

* Evaluate the efficacy of two different dosages of FLEXOFYTOL® versus PLACEBO on arthritis-related and inflammatory biomarkers.
* Evaluate the efficacy of two different dosages of FL EXOFYTOL® versus PLACEBO on pain and function.
* Evaluate the tolerance, the compliance and the patients' satisfaction.
* Evaluate the use of rescue treatments i.e. Paracetamol and oral non-steroidal antiinflammatory drugs (NSAIDs) during the study.

Eligibility Criteria:
Inclusion Criteria:

* Male or female between the age of 45 and 80

Exclusion Criteria:

* Artialis (study coordinator) or Tilman (Sponsor) 's employees
* Participation to a therapeutic clinical trial in the last 3 months
* Under guardianship or judicial protection
Evaluating the Implementation of Portfolio Assessment in Resident Training Program

Portfolios are the records of learning process, providing evidences of experiential learning. It can be a valuable tool not only for understanding the learning process but also for evaluating the accomplishment. Portfolios promote learners to reflecting, thinking, improving in learning as well as achieving learning goals. It has been widely applied in medical education. The goals of resident training outcomes in Wan-Fang Hospital are the ACGME six core competences. The Wan-Fang hospital, one of Taipei Medical University affiliated hospitals and the first implementing portfolio assessment teaching hospitals in Taiwan, will conduct portfolio assessment to assess residents competences. Facilitating residents bring reflective learning into practice, personal and professional growth and demonstrating the outcomes of training program. This study describes initiating and implementing portfolio assessment procedures. Qualitative and quantitative research methods are applied for evaluating the portfolio assessment process and the data of validity and reliability. Qualitative data collection methods of interview, focus groups and meetings will be used understanding the experiences and viewpoints of residents, mentors and assessors. Then quantitative data collection method of questionnaire will be subsequently used. The results of this study will provide experiences and suggestions for the implementation of portfolio assessment system in medical education.


Eligibility Criteria:
Inclusion Criteria:

* residents in Wanfang Hospital willing to be enrolled to this study

Exclusion Criteria:

* none