cyrilzakka/clinical-trials huggingface dataset:
Combined Effect of Insulin and Sodium Hyaluronate Injection Guided by Ultrasound in Carpal Tunnel Syndrome

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. The technique of perineural injection therapy (PIT) is now commonly used for peeling the nerve from surrounding soft tissue (called nerve hydrodissection), which may help to reduce neuro-inflammation, ischemic damage and allow impulse transmission.

The objective of this study is to evaluate the efficacy of ultrasound guided insulin plus Sodium Hyaluronate injection in reducing symptoms caused by carpal tunnel syndrome.

In this randomized clinical trial, 90 patients with both a clinical and electromyographic diagnosis of mild to moderate carpal tunnel syndrome will be recruited from Assiut University Hospital (AUH). After obtaining written informed consent, patients will be randomized into three groups. Group A, patients will receive ultrasound-guided PIT with 10 IU of crystalline insulin; Group B, patients will receive ultrasound-guided PIT with 20 mg of Sodium Hyaluronate; Group C, patients will receive ultrasound-guided PIT with 10 IU of crystalline insulin and 20 mg of Sodium Hyaluronate. The primary outcome will be the Boston Carpal Tunnel Syndrome Questionnaire - Symptom Severity Scale at baseline, 1 month and 3 months post injection. All participants, investigator, outcomes assessor will be blinded (Triple blind)

Eligibility Criteria:
Inclusion Criteria:

* Aged 18 to 65
* Understanding written and spoken Arabic consent
* Diagnostic of carpal tunnel syndrome: Classic of probable based on the Katz Hand Diagram and mild to moderate based on the electrodiagnosis studies

Exclusion Criteria:

* Diseases known to cause carpal tunnel syndrome: Diabetes mellitus, hypothyroidism, connective tissue disease, rheumatic disease and moderate or severe chronic renal impairment
* Secondary diagnosis based on the ultrasound: arthrosynovial cyst, flexor tenosynovitis, ganglion
* Constant symptoms in medial nerve area
* Thenar eminence atrophy
* Cervical radiculopathy
* Brachial plexopathy
* Thoracic outlet syndrome
* Polyneuropathy
* Pregnancy
* Cognitive disorder
* Anticoagulant therapy
* Carpal tunnel injection in the last 6 months
* Ancient ipsilateral wrist fracture
* Ancient ipsilateral wrist surgery
Determination of Heart Rate in Infants Needing Resuscitation at Birth

Algorithms for neonatal resuscitation adapted to low resource settings include HR evaluation by auscultation or umbilical cord palpation at about one minute of life.

Previous studies conducted in high resource settings showed that auscultation of the precordium is more accurate than umbilical palpation to assess HR of healthy infants at birth.The last versions of the American Heart Association and the European Resuscitation Council Guidelines on Neonatal resuscitation suggest that "during resuscitation of term and preterm newborns, the use of 3-lead ECG for the rapid and accurate measurement of the newborn's heart rate may be reasonable". However, this remains a weak recommendation with a very-low-quality evidence.

In low resource countries, a stethoscope is rarely available and palpation of the umbilical pulse is the method used for detecting HR. Although this is preferable to other palpation sites (i.e. femo-ral and brachial artery), there is a high likelihood of underestimating HR with palpation of the umbilical pulse in healthy infants.

The accuracy of assessing HR by auscultation and umbilical palpation in newborn infants requir-ing resuscitation remains unknown.

To the investigator's knowledge, there are not previous studies that have compared the accuracy of HR estima-tion by auscultation vs. umbilical palpation in newborn infants needing resuscitation This study was designed to compare two different methods (auscultation and umbilical cord pal-pation) of HR estimation in newborn infants needing resuscitation, in order to determine which method is most suitable for use in clinical practice.


Eligibility Criteria:
Inclusion Criteria:

1. inborn infants (and)
2. need for resuscitation (and)
3. parental consent; a written informed consent will be obtained by a member of the neonatal staff involved in the study from a parent or guardian at maternal admission to the obstetrical ward or prior to delivery.

Exclusion Criteria:

1. Major congenital malformations;
2. Parental refusal to participate to the study.
Brain and Eye Markers of Facial Expression Recognition and Disorders Associated with Autistic Symptoms

In everyday life, it is necessary to adjust one's behavior and reactions in order to interact and communicate with others in an appropriate manner. This adaptation is done by taking into account the emotions of the people with whom we interact. This reading of emotions is done by using visible clues on the face, in particular by observing the eye area of the interlocutor.

The aim of the study is to investigate how processes such as attention or memory influence emotion recognition, as well as (i) their alteration in the disease, and (ii) their link with the emergence of autistic and/or psychotic symptoms. We also want to study the implementation of compensatory strategies (used to compensate for difficulties in recognizing or perceiving emotions) and the link between the correct use of these strategies and the emergence of autistic and/or psychotic symptoms.

The present project plans to include a total of 120 participants: 30 participants with ASD, 30 patients with a particular genetic deletion 22q11.2 and 60 control participants.

After the inclusion visit, participation in the study will be divided into two half-days in order to perform a neuropsychological assessment, an EEG study and an oculometry study.


Eligibility Criteria:
Inclusion Criteria:

* Person, and if necessary his or her legal representative, who has given his or her non-objection
* Person whose mother tongue is French.
* Person aged between 7 and 50 years old.
* Person diagnosed with ASD according to DSM-5 criteria, person with a genetic syndrome diagnosed by FISH or CGH array (22q11 deletion), person with typical development matched in age and gender.
* Psychotropic treatment unchanged for one month and stable symptomatology.

Exclusion Criteria:

* Recent addiction according to DSM-5 criteria, excluding tobacco.
* Pregnant women.
* Uncorrected visual acuity disorder.
* Use of somatic or psychic medication that may alter brain/psychic functioning (e.g. corticosteroids).
* Neurological disorder of vascular/infectious or neurodegenerative origin.
Health Care Management for the Elderly in Community Through Screening

Depression in late life has been associated with losses in functioning and quality of life, mortality, and increased health care costs. Although late life depression can be successfully treated with antidepressant medication or psychotherapy, few older adults receive adequate trials of such treatment in community in Korea. Barriers, such as loss of loved ones, medical illnesses, and social stigma associated with depression, lack of social and financial support, to effective treatment of depression can be especially problematic for older adult. Screening has been valuable in overcoming barriers to diagnosis. Over 60 year old community dwelling people will be screened for symptoms of four geriatric conditions (depression, dementia, urinary incontinence, and sleep disorder). Those who will be screened positive for each condition will be refer to clinic for diagnosis. Among them only those cases confirmed as depression by psychiatrists will be enrolled in this study. Enrolled patients will be randomly assigned to either case management or usual care conditions.

The objective of the study is to test whether a system of screening, assessment, and follow-up provided by case manager improves in recognizing the target geriatric conditions (depression, dementia, urinary incontinence, and sleep disorder) and healthcare outcomes.


Eligibility Criteria:
Inclusion Criteria:

* over 60 year old
* having medicare insurance

Exclusion Criteria:

* dementia and other psychiatric disorders
Topical Insulin for Postoperative Wound Healing

This study aimed to investigate the potential effect of applying topical insulin therapy on the management and healing of postoperative wounds in patients known with type 2 diabetes mellitus (T2DM) and in a parallel group without diabetes. Investigators also studied the effect of topical insulin therapy on the expression of e-cadherin and Ki67, as markers for cellular proliferation and wound repair. The levels of IL-6 and the H2O2-induced DNA damage product, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were assessed as markers for inflammation and oxidative stress. Finally, histomorphological assessment of skin biopsies was also carried out.

The study participants will be recruited from general surgery department ,all patients with elective surgical procedure who will be admitted at the department for at least one week as it is the minimal duration of postoperative wound healing and the study will be conducted according to the regulations of ethical committee of clinical studies in the Faculty of Medicine, Cairo University

Eligibility Criteria:
Inclusion Criteria:

* Both males and females
* 40-60 years old
* diagnosed with type 2 DM (for the diabetic trial)
* For the diabetic trial: glycosylated hemoglobin (HBA1c) ≤7.5 %
* haemoglobin (Hb) ≥ 12 g/dl
* Patients who had a full thickness post-operative wound of ≥10 cm

Exclusion Criteria:

* Those with known history of immunodeficiency, keloid formation, or hyperkeratotic skin lesion.
* Patients who had hypersensitivity to insulin,
* Patients with severe infection,
* Patients with any severe organ dysfunction
* Patients who were admitted to ICU
Influence of Intruding Angle on Non-graft Osteotome Sinus Elevation

The contour of maxillary sinus matters in osteotome sinus elevation. So does the implant intruding angle between the axis of the implant and the tangent line of the sinus floor contour. The investigators have been engaged in studying the relationship between the outcome of bone formation and the intruding angle, which could guide our clinical decision-making.


Eligibility Criteria:
Inclusion Criteria:

* Patients with residual bone height \>4mm and osteotome sinus elevation together with simultaneous implant placement without grafting

Exclusion Criteria:

* Smokers or patients with systemic disease.
Diagnostic Performance of Spot Urine Sample for the Monoclonal Components Detection in Patients With Multiple Myeloma

The primary objective of the study is to evaluate at Day 1 Cycle 2, the detection sensitivity of the urinary monoclonal component on a spot urine sample, compared to the reference measurement on 24-hour urine, in patients with Multiple Myeloma.

To evaluate the detection sensitivity of the urinary monoclonal component on a spot urine sample, compared to the reference measurement on 24-hour urine, in Multiple Myeloma patients.

300 evaluable patients are required. For each of them, both spot urine sample and 24h urine sample will be collected at Cycle1 Day1, Cycle 2 Day 1 and Cycle 4 Day 1.

The detection of urine monoclonal component will be performed by urine protein electrophoresis (quantitative) and urine immunofixation (qualitative).

Eligibility Criteria:
Inclusion Criteria:

* Patient with Multiple Myeloma
* Patient starting new treatment line, whatever the line is, but with at least 3 induction cycles
* Urine monoclonal component ≥ 200mg/24h

Exclusion Criteria:

-Patients with an emergency planned dexamethasone block administration before the first chemotherapy cycle initiation
Contribution of a Non Medicamentous Approach by Hypnosis on Quality of Life in Crohn Disease

Evaluation of hypnosis therapy efficacy in addition to pharmacologic standard treatment of Croh disease during remission by the evaluation of quality of life;

Crohn disease is defined as an inflammatory chronic disease of the bowel characterize by intermittent flare-ups and remission periods.

Crohn disease is due to genetic and environmental factors such as stress. Stress is an important aggravation factor of the disease symptoms which can stop a remission period and induce a relapse into a flare-up period.

Hypnosis is a non-medicinal technic which already show efficacy in the treatment of functional digestive troubles. These diseases are bio/psycho/social models such as Crohn disease.

Hypnosis can reduce visceral pain sensibility, reduce stress and reduce pro-inflammatory cytokines liberation into intestinal mucosa.

Though, only few data are available on hypnosis interest in the treatment of Crohn disease and inflammatory bowel diseases as it is often isolated clinical case report.

One study on patients with rectocolitis in remission period has been done recently and show that hypnosis increased the duration of the remission period.

The principal objective of this study is to evaluate hypnosis efficacy in term of quality of life for patients with Crohn disease during remission.

Eligibility Criteria:
Inclusion Criteria:

* patient with ileal or colic Crohn disease
* stable treatment for Crohn disease
* clinical and biologic remission (normal C reactive protein and fecal calprotectin \< 100 µg/g)
* patient living in Grenoble area
* informed consent form
* social security affiliation

Exclusion Criteria:

* Person under legal protection (articles L1121-5 and L1121-8 of Public health code)
* Person in exclusion period of another study
* Hypnosis contraindication
Fin Wax Bath Therapy in Patients With Post-traumatic Stiffness of Knee Joint: A Randomized Controlled Trial

Knee traumas termed as any injury or damage to the knee's joint which is caused by different factors like sports injury, accidents and by fall .Knee stiffness is a common complication of femoral and tibia fracture and injuries to the extensor mechanism of the knee.

There are many types of trauma of knee joint such as anterior cruciate ligament (ACL) tear, posterior cruciate ligament (PCL) tears, medial collateral ligament (MCL) tear, lateral collateral ligament (LCL) tear and meniscal tears etc. Post-traumatic knee stiffness is a commonest problem after knee injuries or surgical procedure. It affects significantly patient's quality of life and making daily living activities challenging. Paraffin wax bath therapy involves soaking targeted area in a warm paraffin wax bath pour hot liquid form wax on target area.The heat from the wax increase blood circulation in the affected areas. Mobilization with Movement (MWM) is a type manual therapy technique includes combination of joint mobilization with movement to improve joint mobility, decrease pain and improve functional ability. MWM play a role of application of joint mobilization and active movement simultaneously. The researcher employs a randomized controlled trial methodology.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-40 years.
* Both Male and female
* Fracture of the unilateral knee joint and around the knee managed with conservative treatment only.
* Subjects with post-traumatic stiffness of knee joint having a minimum of 70º knee flexion.
* Able to walk independently or with minimal assistance.
* Administer patient in study after 12 weeks of knee injury.

Exclusion Criteria:

* deformity of hip and knee.
* Implant at fracture and around fracture site.
* Subject having polyarthritis, bleeding disorders, tumors, local infection, peripheral vascular disease, leg-length discrepancy of more than one-half inch.
* History of knee replacement or other knee surgeries within the last six months.
* Presence of neurological conditions (e.g., stroke, multiple sclerosis) affecting gait or knee mobility.
* Known allergy or intolerance to paraffin wax therapy or other study interventions."
Case-control Study on Individual Risk Factors of CTS

This study is conducted to observe the characteristics of the risk factors of CTS in Chinese population.

Carpal tunnel syndrome (CTS), or median neuropathy at the wrist, is a medical condition in which the median nerve is compressed at the wrist, leading to paresthesia, numbness and muscle weakness in the hand. It's the most common neuro-compressive disease. With the development of the modern life, the morbidity of CTS is also raised. As a common disease, the study on etiology is very important in Carpal Tunnel Syndrome, which can improve the life quality of patients with carpal tunnel syndrome. The risk factors include individual factors such as age, gender, diabetes, Hypothyroidism, obesity, complication of systematic diseases, tobacco, injury and occupational factors.

As most of the research were based on the population in western country and the life style and the ethnicity between Chinese people and western country people is quite different, there may be some similarities and differences in epidemiology. There is seldom similar research in China so that this study was conducted to observe the characteristics of these risk factors in Chinese population.

Eligibility Criteria:
Inclusion Criteria:

* with the symptom "numbness"
* clinical and neural-electrophysiological diagnosed CTS

Exclusion Criteria:

* suffered from other diseases that could cause "numbness" diagnosed clinically
Hepcidin Behavior in Patients With Obesity and Bariatric Surgery

Iron deficiency is one of the most common nutritional problems observed in patients with obesity and after bariatric surgery. From a therapeutic point of view, iron deficiency can lead to iron deficiency anemia. Iron supplementation carries the risk of exacerbating infections, altering the gut microbiome and iron overload. Therefore, it would be beneficial to use iron supplementation only in truly iron deficient patients. To date, different studies have observed that hepcidin could be a possible indicator of iron status and absorption in different patient populations. Furthermore, it could be used to distinguish anemia due to iron deficiency from inflammation and globin disorder related anemia. How hepcidin concentrations variate in patients with obesity and after bariatric surgery remains unsure.

During the visit in the obesity clinic, eligible patients will be approached for participation by the sub-investigator. Interested patients will receive information regarding the study and receive the information sheet containing the informed consent form. After signing the informed consent form, general information will be collected regarding medical and demographic data using a short questionnaire. Additional questionnaires regarding demographics and menstrual cycle will be collected. Anthropometric measurements will be collected for the determination of the length, weight, hip circumference, waist circumference and body composition. Finally, blood samples will be collected for the determination of iron and inflammation related markers.

Eligibility Criteria:
Inclusion Criteria:

* The patient has to be 18 years or older
* Written informed consent has to be obtained after being informed on all aspects of the study
* The patient has a BMI \> 30 kg/m² OR There has to be at least one year between the primary RYGB and the participation in the study OR There has to be at least one year between the primary SG and the participation in the study

Exclusion Criteria:

* Patients younger than 18 years old
* Women who are pregnant or are breastfeeding
* Post-menopausal women, defined as at least 6 months of amenorrhea after the final menstrual period
* Inability to follow the procedures of the studies due to language problems
* Patients who have had more than one bariatric surgery
Lovastatin and Its ß-hydroxy Acid From Four 600 mg LipoCol Forte® Capsules Compared to That of One 20 mg Mevacor® Tablet in Healthy Subjects

The objective of the study is to evaluate the relative bioavailability of lovastatin and its ß-hydroxy acid of 600 mg LipoCol Forte® Capsules compared to that of one 20 mg Mevacor® Tablet after single oral administration in healthy subjects using a 2x2 crossover design.

Healthy subjects were randomly allocated to receive a single dose of either four 600 mg red yeast rice capsules or one 20 mg lovastatin tablet; after 7-day washout period, they received a single dose of the alternative drug. The subjects were fasted at least 10 hour before dosing. The investigational products were administered with 240 mL of water with the subject in an upright position. The blood samples were collected at prior to the drug administration (T0), and 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8 and 12 hours after dosing.

Eligibility Criteria:
Inclusion Criteria:

1. Subjects must be at the age of 20-40 years old and in good health on the basis of medical history, physical examination, electrocardiogram, chest X-ray, and routine laboratory evaluations.
2. Vital signs (after 3 minutes resting in a upright position) which are within the following ranges:Ear body temperature between 35.0-37.5 degree celsius (°C). Systolic blood pressure, 90-140 millimeters of mercury (mm Hg). Diastolic blood pressure, 50-90 millimeters of mercury (mm Hg). Pulse rate, 50-90 beats per minute (bpm). Fasting blood glucose, \< 110 milligrams per deciliter (mg/dL).
3. Body weight must be above 50 kilograms (kg) and within -20 to +20% of ideal body weight.
4. Able to sign informed consent prior to study.
5. Able to communicate well with the investigator and comply with the requirements of the study.

Exclusion Criteria:

1. Use of any prescription medication within 14 days prior to dosing.
2. Use of over-the-counter medications or vitamins within 14 days prior to dosing.
3. Significant illness within 2 weeks prior to dosing.
4. Participation in any clinical investigation within 2 months prior to dosing or longer than required by local regulation.
5. Donate or loss more than 500 milliliter (mL) of blood within 3 months prior to dosing.
6. Presence of cardiovascular disease.
7. Presence of gastrointestinal disease.
8. Presence of asthma or lung disease.
9. Presence of liver disease or liver injury as indicated by an abnormal liver function profile.
10. Presence of impaired renal function.
11. Presence of neurological disease.
12. Presence of psychiatrical disease.
13. A known hypersensitivity to lovastatin and Chinese Red Yeast Rice or their analogs.
14. History of drug or alcohol abuse within 12 months prior to dosing.
15. Permanent confinement to an institution.
16. Pregnant or lactating women.
17. Individuals are judged by the investigator or co-investigator to be undesirable as subjects for other reasons.