cyrilzakka/clinical-trials huggingface dataset:
Effects of Plyometrics Versus Conventional Exercises on Speed, Strength, and Injury Prevention in Bowlers.

To compare the effects of upper body plyometric versus conventional exercises on speed, strength, and injury prevention in bowlers

Bowling action is a highly skilled activity acquired over the year. A bowler needs speed and strength to challenge the batsman but the conventional protocols they follow for the speed and strength are not specific to their bowling actions. Bowling can result in different types of upper extremity injuries, such as rotator cuff sprains, impingement and stress fractures. There are many injury prevention programs such as electrostimulation training, resistance training, and plyometric training that can be used to treat upper limb injuries and improve maximal strength.

Plyometric training can be done by overhead athletes to improve the effectiveness of throwing activity and to strengthen the rotator cuff muscles to prevent shoulder injury from overhead throwing activity.

This study aims to evaluate the effectiveness of upper limb plyometric exercises on speed, strength and injury prevention in comparison with conventional exercises.

Eligibility Criteria:
Inclusion Criteria:

* Players bowling for at least one year
* Bowlers age 18 to 35 years

Exclusion Criteria:

* Any acute or chronic musculoskeletal injuries
* Any surgery in 6 months
Prospective Evaluation of the Fluid Rapid Influenza Test

The primary objective of this study is to evaluate the fluID Rapid Influenza Test's ability in detecting influenza A and influenza B from individuals presenting with signs and symptoms of influenza-like illness (ILI).

The primary objective of this study is to evaluate the clinical sensitivity and specificity of the fluID Rapid Influenza Test in detecting influenza A and influenza B, as evaluated with respect to fresh samples collected prospectively from individuals presenting with signs and symptoms of influenza-like illness (ILI). Test results will be compared with those obtained from viral culture testing of samples using the same specimen types, obtained from the same subjects. The specimen types under evaluation in this study will be nasal swab, nasopharyngeal swab, nasal wash and aspirate specimens.

A secondary objective of this study is to evaluate the accuracy of the fluID Rapid Influenza Test in detecting each of the H1 and H3 subtypes of influenza A, in nasal swab, nasopharyngeal swab, nasal wash and aspirate specimens.

Eligibility Criteria:
Inclusion Criteria:

1. Male or female subjects of any age;
2. Subjects presenting to the investigative site within 4 days of symptom onset, with:

   * Fever ≥ 38.0°C (100.4°F) if taken orally, or ≥ 38.5°C (101.2°F) if taken rectally; or a self-reported history of fever or feeling feverish (includes fever controlled by medication) in the absence of documented fever;
   * One or more respiratory symptoms of influenza-like illness which may include the following:
   * Sore throat;
   * Runny or stuffy nose;
   * Cough;
   * One or more constitutional symptoms of influenza-like illness which may include the following:
   * Myalgia (aches and pains);
   * Headache;
   * Fatigue;
3. Subjects (or parent/guardian) willing and able to provide informed consent. Written subject informed consent for this study protocol must be obtained prior to study enrollment. Each subject (or parent or guardian) must personally sign and date the Subject Informed Consent Form prior to his/her participation in this clinical study.

Exclusion Criteria:

1. Subjects not presenting with at least three symptoms of influenza-like illness as outlined above.
2. Subjects who have received influenza antiviral medication or an investigational influenza drug treatment within the previous 30 days of study enrollment.
3. Subjects (children and adults) for whom the obtaining of swab samples, nasal wash or aspirate samples is contraindicated or not possible.
4. Subjects with a medical condition that prevents swab samples or nasal washes or aspirate samples from being obtained.
5. Active duty military personnel (participating military study sites only).
6. Subjects (or parent/guardian) unwilling or unable to provide informed consent.
Mental Health Assessment Among Community Member During the Covid-19 Pandemic in Indonesia

The Covid-19 pandemic in Indonesia makes several changes in daily living. The Indonesian government suggests that everyone should stay at home by implements the work from home and school from home. Therefore, the issues related with Covid-19 are also worrying such as death because of the infection, virus transmission, doing everything from home such as Friday praying for Moslem, Sunday service at home, etc. People is anxious whenever meeting people because they are not really understand whether people is infected or not. Therefore, this study tries to identify the impact of Covid-19 pandemic in Indonesia towards mental well-being of the community.

The Covid-19 pandemic in Indonesia makes several changes in daily living. The Indonesian government suggests that everyone should stay at home by implements the work from home and school from home. Therefore, the issues related with Covid-19 are also worrying such as death because of the infection, virus transmission, doing everything from home such as Friday praying for Moslem, Sunday service at home, etc. People is anxious whenever meeting people because they are not really understand whether people is infected or not. Therefore, this study tries to identify the impact of Covid-19 pandemic in Indonesia towards mental well-being of the community. The aims of this study are trying to collect and identify the most important aspect of mental health that affected by the Covid-19 pandemic in Indonesia, and using this data we are trying to propose the exact mental health promotion and prevention program for the community. The study design is cross sectional. We develop the questionnaire that suitable for our study, consists of demographic data, life experience data. In addition, for assessing mental health problems, the study uses PHQ-9, SRQ-20, GAD-7, SDQ for children 4 - 10 years old and 11 - 17 years old. The study is done by online survey. The data analysis is done by SPSS for mac version 21.

Eligibility Criteria:
Inclusion Criteria:

* Willing to participate on this study by signing the informed consent

Exclusion Criteria:

* No
Chemotherapy for Elderly Patients Diagnosed With Localized HER2 Positive Breast Cancer

There is major concern regarding chemotherapy related toxicity in the group of women older than 65 years old diagnosed with human epidermal growth factor receptor 2 (HER2) positive breast cancer (BC). Nevertheless, these patients are at a particularly high risk of breast cancer recurrence and death. Of note, older patients may experience higher risk for Trastuzumabe related cardiotoxicity, especially when this agent is combined with an anthracycline.

Recent studies have shown extremely favourable outcomes in early HER2+ BC patients treated with a combination of paclitaxel and trastuzumab, omitting anthracyclines from treatment.

Investigators sought to investigate safety and outcome data on a cohort of elderly patients treated with weekly paclitaxel combined with carboplatin and trastuzumab.

Breast cancer is the most common female cancer and the second most common cause of cancer death in women. BC incidence is markedly increased with aging.

Amplification or overexpression of HER2 oncogene is present in approximately 18 to 20% of primary invasive BC. In the absence of HER2 target therapy combined with adjuvant or neoadjuvant chemotherapy, HER2 overexpression or amplification is associated with high rates of disease recurrence and death.

There is major concern regarding chemotherapy related toxicity in the group of women older than 65 years old diagnosed with HER2 positive breast cancer. Nevertheless, these patients are at a particularly high risk of breast cancer recurrence and death. Of note, older patients may experience higher risk for Trastuzumabe related cardiotoxicity, especially when this agent is combined with an anthracycline.

Recent studies have shown extremely favourable outcomes in early HER2+ BC patients treated with a combination of paclitaxel and trastuzumab, omitting anthracyclines from treatment.

Investigators sought to investigate safety and outcome data on a cohort of elderly patients treated with weekly paclitaxel combined with carboplatin and trastuzumab.

Eligibility Criteria:
Inclusion Criteria:

* Clinical or Pathological Stage I- IIIA breast adenocarcinoma.
* HER2 overexpression or amplification defined by immunohistochemistry staining of +3 or positive fluorescence in situ hybridization (FISH) test.
* Age ≥ 65 years old.
* WHO performance status less than 2; adequate hematologic (granulocyte count ≥ 2 X 109/L, platelet count ≥100 X109/L) and hepatic (transaminases ≤ 1.5 X the upper limit of normal (ULN), alkaline phosphatases ≤ 2.5 times ULN, and bilirubin ≤ ULN) tests; and normal cardiac function (baseline left ventricular ejection fraction at least ≥ 55%)

Exclusion Criteria:

* Radiologic imaging of metastatic disease.
* History of cardiac disease contraindicating anthracyclines, uncontrolled essential hypertension or diabetes, stroke or any other comorbidity that could potentially compromise chemotherapy treatment, such as chronic obstructive pulmonary disease.
* Any previous treatment with anti HER2 therapy.
Sorafenib to Treat FLT3-ITD AML

It is a prospective, non-interventional, open-label study, in order to observe the safety and response in FLT3-ITD mutation positive AML patients who receiving sorafenib as induction, consolidation, salvage, maintenance or alleviative treatment. The duration of the study from June 2014 through May 2019, with the recruitment duration from June 2014 to May 2017. The inclusion criteria is:

1. Definitely diagnosed as AML
2. FLT3-ITD mutation has been confirmed
3. Accepting the prescription of sorafenib


Eligibility Criteria:
Inclusion Criteria:

* Definitely diagnosed as AML
* FLT3-ITD mutation has been confirmed
* Accepting the prescription of sorafenib

Exclusion Criteria:

* Can not take drugs orally
* Can not follow the doctors' advices
* Other reasons that investigators considered as contra-indications for this study
Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application

The Curetis Unyvero LRT55 Application is intended to detect and to identify genes of 21 microorganisms and 19 genes associated with antibiotic resistance in 4 hours.

In this study, the performance of the Unyvero LRT55 Application shall be tested under clinical conditions and compared to (1) a composite reference method (for non-atypical or cultured microorganisms) or (2) a molecular PCR based reference method for the 3 atypical microorganisms Chlamydophila pneumoniae, Legionella pneumoniae, and Pneumocystis jirovecii, and for resistance genes.

PCR amplifications are followed by bi-directional sequencing, including comparison of the test results Time to result will be compared for the Unyvero LRT55 Application and standard-of care.

This is a non-interventional, controlled, non-randomized multicenter clinical study that compares a new diagnostic device, the Unyvero LRT55 Application (based on molecular diagnostic methods) to either (1) a composite reference method (for non-atypical microorganisms), (2) a composite PCR-based method for 3 atypical microorganisms or (3) a PCR-based reference method for resistance genes.

The study will use leftover lower respiratory tract samples taken from subjects suspected with lower respiratory tract infections: (a) Specimens taken prospectively for standard-of-care (i.e. microbiology testing) from hospitalized subjects. (b) Banked specimens for rare microorganisms.

As the device is under investigation, the test results provided by the Unyvero LRT55 Application will not be made available to the treating physician and therefore will not be used for diagnosis, treatment or other management decisions.

Eligibility Criteria:
Inclusion Criteria:

* Hospitalized subjects with suspicion of lower respiratory tract infection
* Age at least 18 years
* Available surplus respiratory aspirate or bronchial lavage sample

Exclusion Criteria:

* Out-patient (ambulatory patient)
* Known infection with HIV, HBV or tuberculosis
The Importance of Exercise to Prevent Injuries in Athletes

Introduction: running is one of the most accessible and practiced sports in the world since the 21st century. Unfortunately, the incidence of injuries in the population that practices it is high regardless of experience, although the risk of injury increases in amateur runners. One of the main keys to reduce the incidence of running related injuries may be to improve the ability to reduce the load or impact. For this, there are different strategies such as a gradual increase in the load to run, and exercise within which is muscle strengthening and balance training or proprioception.

Objective: to verify the effectiveness of a program of proprioceptive exercises based on the static and dynamic balance for the reduction of lower limb injuries in amateur runners during the competition season.

Methodology: 66 amateur runners, after simple size calculation, will be randomized into two groups. Experimental group will carry out the proprioceptive exercise program during 8 weeks at the begining of the season and control group will continue with their usual training routine. The main variable running related injury will be collected weekly during the follow-up.

Results: When all the data needed for the study has been collected, researchers gathers results and exports them for statistical interpretation.

Eligibility Criteria:
Inclusion Criteria:

* Weekly training of at least 15 kilometers.
* At least practice running 6 months for 1-3 times a week.

Exclusion Criteria:

* To have some type of lower limb or lower back injury at present or in the last 6 months.
* Having undergone surgery for any back or lower limb injury.
* Pregnant.
* Neural dysfunction / disability.
MEP and Neuromuscular Blocker

It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.


Eligibility Criteria:
Inclusion Criteria:

1. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential

Exclusion Criteria:

1. Central or peripheral neuromuscular disease
2. Sensory or motor nerve disorder
3. Allergy to propofol, remifentanil, and rocuronium
4. Patients with pacemaker
Low Intensity Shock Wave Therapy in the Management of Erectile Dysfunction

Researchers are evaluating the efficacy of low intensity shockwave therapy (LISWT) via MoreNova in the treatment of erectile dysfunction (ED).

ED is broadly defined as the inability to achieve or maintain an erection sufficient for sexual intercourse or activity. Current treatment for ED consists of oral medications, intracavernosal injections and surgically placed penile prosthetics. In the literature this has been described as a Stepwise Approach, offering therapy beginning with the least invasive treatment option.

The goal of LISWT is to restore natural erections and / or improve responses to oral medications (first line therapy).

LISWT for ED is under evaluation in the USA. The European Association of Urology Guidelines on ED were recently updated to include LISWT for men with mild to moderate ED. The energy/pulse used in this application is approximately 10% of the energy used for disintegrating kidney stones; no serious side effects have been reported. Shock wave therapy for diabetic ulcers has recently been approved by the FDA.

Eligibility Criteria:
Inclusion Criteria:

* The patient must have given his informed and signed written consent
* The patient is a male
* Between 40 to and including 55 years of age
* The patient has ED for longer than 1 year but less than 5 years.
* The patient is PDE5i responsive, meaning he is able to achieve and maintain an erection under the effect of the maximal dosage of PDE5i
* IIEF-EF Domain score of 17-20
* Evidence Based Criteria: Doppler Clinical Exam

Exclusion Criteria:

* The patient is participating in another study that may interfere with the results or conclusions of this study
* History of radical prostatectomy or extensive pelvic surgery
* Past radiation therapy of the pelvic region within 12 months prior to enrollment
* Recovering from cancer within 12 months prior to enrollment
* Neurological disease which effects erectile function
* Psychiatric disease which effects erectile function
* The patient is taking blood thinners
* History of Diabetes Mellitus
* History of Coronary Artery Disease
* Evidence Based Criteria: Doppler Clinical Exam
* Severe erectile dysfunction with IIEF-EF domain score \< 16
A Open-label, Single-dose, 2-Sequence, 2-Period, Crossover Study to Assess Safety and Pharmacokinetics of a Nateglinide/Metformin HCl Combined Tablet Compared With a Nateglinide 120 mg Tablet and Metformin HCl 500 mg Tablet Under Fasting Conditions in Healthy Male Subjects

A Randomized, Open-label, Single-dose, 2-Sequence, 2-Period, Crossover Study to Assess Safety and Pharmacokinetics of a Nateglinide/Metformin HCl Combined Tablet Compared with a Nateglinide 120 mg Tablet and Metformin HCl 500 mg Tablet under Fasting Conditions in Healthy Male Subjects


Eligibility Criteria:
Inclusion Criteria:

* Age between 20 and 40
* Signed informed consent

Exclusion Criteria:

* Has a history of hypersensitivity to IP ingredients
* Hypertension or hyportension
Comparison of Inflammatory Responses Subsequent to Different Cesarean Section Techniques

In this study, the investigators aimed to find out whether there are any differences in inflammatory reactions occured subsequent to two different cesarean delivery techniques; modified Misgav-Ladach vs Pfannenstiel-Kerr techniques.

Cesarean section is one of the most undertaken operations in women of childbearing age. However, there is not a unique cesarean surgery technique. Pfannenstiel , reported his own technique in 1897. Because of the applicability of the technique, it went down well among obstetricians. After three decades, Kerr evolved this technique, and Pfannenstiel-Kerr technique became the method of choice until late 70's. In 1972, Stark et al defined the Misgav Ladach technique and in the following years this technique became popular among obstetricians. In late 80's Misgav Ladach technique was modified and started to be more popular. But, still Pfannenstiel-Kerr technique continued to be used frequently and studies comparing clinical outcomes of these two techniques were conducted for several times. However, the inflammatory responses which occured subsequent to application of these techniques were not investigated. This is the first study investigating the inflammatory response emerged after different cesarean surgery techniques.

Eligibility Criteria:
Inclusion Criteria:

* Cesarean section for the first time
* Term,singleton pregnancy

Exclusion Criteria:

* Any inflammatory disease
* Any pregnancy complication; IUGR,preeclampsia,preterm labor,preterm premature rupture of membranes
* Pregnancies \<37weeks gestational age
Hands on - a Hand Care Guide in Systemic Sclerosis

Hands are commonly affected in Systemic Sclerosis (SS). The objective of this research is to apply a home based hand care guide in patients with SS and to evaluate its response regarding hand pain, function, strength and mobility.

Introduction: Hands are commonly affected in Systemic sclerosis (SS). Skin thickening, Raynaud phenomenon, digital ulcers and cutaneous calcinosis may result in pain, disability and claw deformity. Strategies to improve hand function are recommended since its diagnosis and throughout the treatment. Unfortunately hand care assistance is not often available. The objective of this study was to developed a brief guide about hand care and home-based exercises to be applied in our outpatient clinic.

Methods: A brief program , with instructions about the disease and home-based exercises will be applied in a group patients with Systemic Sclerosis (SS) during the period of 12 weeks. Hand function (Cochin Hand and Functional Scale), disability (HAQ-Scleroderma), quality of life (SF-36 hand pain (visual analogue scale), grip and pinch strength, hand mobility (delta finger) will be assessed in the first appointment and after twelve weeks.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of Systemic Scleroderma according to the American College of Rheumatology (Criteria Committee, Arthritis Rheum. 2013).
* Involvement of hands with skin thickening.
* Interest in participating in the investigation
* Ability to read and to answer the the proposed questionnaires

Exclusion Criteria:

* Upper limb commitment due other reasons other than Systemic Sclerosis.
* Presence of digital ulcers, hand deformities or conditins that impede the realization of the proposed exercises
* Clinical manifestations that impede the performance of the proposed exercises
Study of Atorvastatin Dose Dependent Reduction of Proteinuria

Randomized controlled double blind study of parallel groups to evaluate the comparative effects of low-dose of atorvastatin on proteinuria in patients with stage 3 or 4 chronic kidney disease.


Eligibility Criteria:
Inclusion Criteria:

* Age of 18 and over
* Stage 3 or 4 chronic kidney disease (modified MDRD)
* proteinuria of \> 1g/d on ACEi and/or ARB, or proteinuria of \> 1g/d with intolerance or contraindication to ACEi and/or ARB
* blood pressure \< 130/80 mmHg or \< 140/90 mmHg in patients with five or more antihypertensive drugs
* stable renal function

Exclusion Criteria:

* rapid progression of renal failure
* immunosuppressive therapy within the past 3 months
* need a renal replacement therapy within 8 months
* definite history of chronic liver disease, or abnormal liver function
* evidence of active inflammatory muscle disease
* definite previous adverse reaction to a statin
* concurrent treatment with a contraindicated drug (fibrate, macrolide antibiotic, systemic use of imidazole or triazole antifungals, protease-inhibitors, ciclosporin)
* child bearing potential
* known to be poorly compliant with clinic visits or prescribed medication