cyrilzakka/clinical-trials huggingface dataset:
Pulse Oximetry Readings and Hourly Variation in Oximetry Readings With CHD

The aim of this study is to describe the presenting pulse oximetry reading in patients who have a known lesion which will cause them to have a low presenting oximetry reading. The study hypothesis is that there is a low presenting pulse oximetry in patients with congenital heart disease and that there will be no significant variation in the hourly variation in oximetry readings in these patients.

Congenital heart disease is a relatively common disease seen in 8/1,000 live births. Many of these diseases are associated with hypoxemia. Hypoxemia results from the mixing of pulmonary and systemic blood or from the mixing of parallel circulations as seen in transposition of the great vessels. Pulse oximetry can be used to measure hypoxemia. Pulse oximetry estimates oxygen saturation by measuring absorption of light in human tissue beds. The amount of light absorption varies depending on the amount of deoxygenated blood in the tissue measured. Measuring the changes in light absorption allows for an estimation of arterial oxygen saturation and therefore the amount of hypoxemia. Most manufacturers claim a confidence interval of 4% for their oximeters. There have been a few studies recently describing the presenting pulse oximetry of known congenital heart disease. However, these were small studies with a small sample size of patients. Moreover, there is no literature describing the hourly variation in pulse oximetry among know congenital heart disease patients.

We hypothesize that there is a low presenting pulse oximetry in patients with congenital heart disease and that there will be no significant variation in the hourly variation in oximetry readings in these patients.

This is a retrospective chart review examining the presenting pulse oximetry of patients with known cyanotic heart lesions. The treatment group will be untreated patients with known lesions. All charts of children presenting to Sibley Heart Center with known cyanotic heart lesions from January 1, 2004 to December 31, 2004 will be reviewed.

The aim of the study is to describe the presenting pulse oximetry reading in patients who have a known lesion which will cause them to have a low oximetry reading. The following information will be collected from the charts:

* Presenting pulse oximetry
* Heart lesion

The second aim will be to characterize the hourly variation in pulse oximetry from these patients. The following information will be collected:

* Hourly pulse oximetry readings
* Heart lesion
* Clinical course

Eligibility Criteria:
Inclusion Criteria:

* congenital heart lesion
* presenting to Sibley Heart Center
* initial visit between Jan. 1, 2004 and Dec. 31, 2004

Exclusion Criteria:

* those who do not meet inclusion criteria
Dual-focus Survey with an Emphasis on Heated Humidification Systems

Under normal circumstances the upper airway and respiratory tract play a crucial role in humidifying and warming inhaled air, a process known as inspired gas conditioning. This process is essential for effective gas conditioning and mitigating the potential risk of damaging the structure and function of the respiratory epithelium. Airway instrumentation, such as the use of an orotracheal tube or tracheostomy cannula, interferes with the physiological conditioning of inspired gas. Furthermore, the administration of cold, dry medical gases, together with the high flows experienced by patients under invasive mechanical ventilation (IVM) or non-invasive mechanical ventilation (NIMV), exacerbate this unfavorable condition. Therefore, the incorporation of an external device to condition the delivered gas becomes imperative, even in short-term interventions.

There are different devices to condition the inhaled gas, basically passive humidification systems (HMEF) and active (or heated) systems. Considering the humidification capacity and advantages and disadvantages, both passive and active systems are suitable for conditioning the inhaled gas.

The hyphotesis of this study is that health teams in Latin America have limited knowledge regarding humidification systems, both from the technical aspects of implementation and from the clinic.

OBJECTIVES

Primary aim:

Develop an instrument to evaluate knowledge about humidification systems among different health professionals in intensive care units (ICU).

Describe the knowledge about humidification systems among different health professionals in intensive care units (ICU).

Secondary aim:

Compare knowledge about humidification systems between different countries. Compare knowledge about humidification systems between different specialties. Compare knowledge about humidification systems in different age groups.


Eligibility Criteria:
Inclusion Criteria:

* Doctor, nurse, respiratory therapist or related titles
* More than 2 years of work experience in an adult ICU (work in the ICU will be considered as work carried out at least 12 hours per week in the critical care unit)

Exclusion Criteria:

* ≥10% missing survey data
Comparison Between Ultrasonographic Cervical Length and Bishop Score in Preinduction Cervical Assessment

To compare the ultrasonographic cervical length with the Bishop score in determining the administration of prostaglandin for preinduction cervical ripening in nulliparas at term.


Eligibility Criteria:
Inclusion Criteria:

* nulliparous patients
* singleton pregnancy
* live fetus with vertex presentation
* intact amniotic membranes
* \> 37 weeks gestation
* absence of labor
* no previous uterine surgical procedures

Exclusion Criteria:

* major congenital anomaly
Vascular Surgery Admissions in a Tertiary Care Hospital in the Mid-West: A 12 Month Profile.

Creating a 12 month profile of Vascular Surgery Admissions aims to inform service delivery and optimise patient care resources. There is a gap in the literature pertaining to this topic, particularly from an Irish perspective. This research could inform a clinical pathway to reduce LOS for patients cared for by the Department of Vascular Surgery.

This is an observational cross sectional study. This study will be mixed methods. Following the profile creation the researcher aims to complete qualitative research in the form of interviewing a cohort of vascular patients about their experiences in order to inform practice development. Ethics approval will be granted prior to any activities taking place.

Selection/Recruitment:

Patients attending UHL deemed to have vascular care needs and assigned to the care of a Vascular Consultant will be included in this study. The data will be collected 12 months from the date of commencing the study. Vascular consults will be excluded for the purpose for this research unless care is transferred. Informed consent is not required for this research so there in no exclusion criteria in relation to ability to provide same.

Data Collection:

The data to inform this project will be collected from medical chart review and utilising the UHL inpatient IT systems. No patient identifiers will be collected for this research and it will comply with GDPR. The Ipims system will be used to measure current inpatients under the care of a Vascular Consultant. HIPE data will be requested to examine the length of stay for vascular inpatients. The individual's medical notes will be reviewed to assess:

* Reason for admission to hospital and/or presentation to the Emergency Department (ED).
* Date, day and time of admission.
* Referral source.
* Categorisation from triage in the ED if applicable.
* Consultant caring for the individual.
* Demographic profile \& Brief Medical and Surgical History.
* ? Elective or Emergency admission.
* ? Intervention or conservative management. Treatment course.
* ? Re-admission.
* Length of stay.
* Time patient waited for theatre procedure (date of admission to date of theatre) including fasting time.
* Time patient waited for vascular scans (date of admission to date of scans) \& scans completed.
* Time patient waited for rehab (transfer) if applicable.
* Time patient waited for OPAT if applicable.
* Clinical Frailty Scale (Appendix II) \& Charlson Co-Morbidity Scale (Appendix III) (no patient intervention required).

Data Analysis:

Descriptive statistics with multivariant analyses.

Process Evaluation:

The MRC Framework will be employed for process evaluation.

Eligibility Criteria:
Inclusion Criteria:

* Patients attending UHL deemed to have vascular care needs and assigned to the care of a Vascular Consultant will be included in this study.
* The data will be collected 12 months from the date of commencing the study.

Exclusion Criteria:

* Patients outside of the set dates will be excluded.
* Vascular consults will be excluded for the purpose of this research unless care is transferred.
Clinical Trial to Analyze Lateralized Models and Medializations of Inverted Arthroplasty.

To determine the functional outcomes, complications and muscle performance by isokinetic study of two reverse arthroplasty systems (one with medialized center of rotation and the other with lateralized center of rotation) in the treatment of rotator cuff arthropathies or irreparable cuff tears.

This is an experimental, prospective, unblinded, randomized, comparative clinical trial between patients with two types of prosthetic implants (inverted arthroplasty with medialized center of rotation vs inverted arthroplasty with lateralized center of rotation). Those male or female patients who meet the inclusion criteria will be selected to form part of one of the two randomly distributed study groups. Sample size Based on studies with similar characteristics but where lateralization is not performed with the implant but with a bone graft would require a sample size of 34 patients (17 in each group) assuming 20% losses with a Type I error of 0. 05 and a statistical power of 80% to show a difference of 10 points on the Constant scale (the minimal clinically important difference on the Constant scale for reverse arthroplasty is described as 8 points in previous comparative studies so we consider the detection of a difference of 10 to be sufficient. The minimal clinically important difference for function and strength in patients undergoing reverse shoulder arthroplasty. The final N needed would be 42 patients (21 per group). A randomization of patients will be performed to assign them to one or the other study group, which will be carried out by an independent assistant, who will generate a random sequence that will be unknown to the investigators. Each patient will be given a sealed and numbered envelope to choose from, in which the randomized group in which he/she has been included will be determined. The study will be blinded for the patient and rehabilitator but not for the surgeon.

Eligibility Criteria:
Inclusion Criteria:

1. Male or female patients over 65 years of age with rotator cuff arthropathy refractory to conservative treatment after six months.
2. Ability to understand the information sheet, informed consent and evaluation scales.

   Exclusion Criteria:

   Patients with sequelae of fractures, rheumatoid arthritis, avascular necrosis, primary glenohumeral arthrosis, revision surgeries that have required conversion to a ATHI
3. Patients in whom another surgical procedure has been associated with ATHI such as a tendon transfer
4. Glenoid bone defects in the horizontal plane (Type B2 and C of the Walch classification) or in the vertical plane (E3 Sirveaux).
Assessment of Cod Protein as an Insulin-sensitizing Agent in Women With Polycystic Ovary Syndrome.

The objective of our study is to determine the effects of fish protein on insulin sensitivity in PCOS women with insulin resistance, and its mechanism of action on glucose and endocrine metabolism. Our working hypothesis is that dietary fish protein improves insulin sensitivity, glucose tolerance, and related plasma endocrine and lipid abnormalities in PCOS women by restoring secretory β-cell function and insulin signaling to the PI 3-kinase activity/Akt pathway. We further hypothesize that fish protein will improve cycle regularity and ovarian function.

Women with polycystic ovary syndrome are at high risk of developing diabetes. Apart from a primary ovarian defect, up to 10% and 40-50% of those women develop diabetes and insulin resistance (IR) respectively. IR and associated hyperinsulinemia are recognized as important pathogenic factors in determining diabetes in the majority of PCOS women, particularly when obesity is present. Treating IR might reduce the risk of diabetes and improve ovulation and fertility in PCOS women. We recently found that obese, IR men and women consuming a cod protein diet showed a 30% improvement in insulin sensitivity compared with other animal proteins, and also a 24% decrease in high-sensitive C-reactive protein plasma concentration. Therefore, dietary fish protein could represent a natural, safe and practical means to improve insulin sensitivity in PCOS women with IR, and a new non-pharmaceutical approach for the treatment of the multiple endocrine and metabolic abnormalities of PCOS women (see outcome measures for a more extensive description).

Eligibility Criteria:
Inclusion Criteria:

* women
* 18 to 45 years old
* having polycystic ovarian syndrome
* overweight (BMI\>27)
* insulin resistance based on fasting insulin levels in the upper 95th percentile (\>90pmol/L)
* non-diabetic

Exclusion Criteria:

* diabetes
* hysterectomy
* abnormal endometrial biopsy if abnormal bleeding in the last 6 months
* clinical evidence of Cushing's syndrome
* congenital adrenal hyperplasia (17-OH progesterone\>10nmol/l)
* excessive androgens suspicious of a tumour
* prolactins levels \>50μg/l
* previous breast, uterus, ovary or liver neoplasia
* use of medication known to affect glucose and lipid metabolisms (e.g. steroid hormones, oral contraceptives, ß-blockers, glitazones, statins, insulin)
* depo-medroxyprogesterone acetate injection in the last year
* important weight loss or weight gain within the last 6 months
* chronic, metabolic (except well controlled chronic hypothyroidism) or acute disease or major surgery within the last 3 months
* dietary incompatibility with calcium supplementation and/or fish consumption (allergy, intolerance, dislike)
Comparison of Dynamic Neuromuscular Stabilization Exercises and Deep Cervical Muscle Exercises on Muscle Fat Infiltration in Individuals With Neck Pain

This clinical trial study aims to compare the effects of DNS (Dynamic Neuromuscular Stabilization) exercises and deep cervical muscle exercises on fat infiltration, disability, and posture in individuals with chronic non-specific neck pain. The clinical questions of this study are as follows:

* Can DNS and deep cervical muscle exercises decrease muscle fat infiltration?
* Can DNS and deep cervical muscle exercises improve neck disability?
* Can DNS and deep cervical muscle exercises improve neck posture?

Researchers will compare DNS and deep cervical muscle exercises to people with non-specific neck pain. DNS exercises are hypothesized to significantly reduce fat infiltration and improve neck disability and neck posture compared to deep cervical muscle exercises.

The participants will undergo an MRI scan and clinical assessment, such as NDI (Neck Disability Index) and posture checking, before being randomly divided into two groups. The first group will perform DNS exercises, and the second group will engage in deep cervical muscle exercises. Both sets of exercises will be performed for 16 weeks as part of a daily routine. After the 16-week exercises, the participants will undergo a follow-up MRI, NDI, and posture checking.


Eligibility Criteria:
Inclusion Criteria:

* Non-specific neck pain condition for three months or more
* Mild to moderate disability ( more than 10% of NDI)
* Mild to moderate pain level(2-8/10 of NRS)

Exclusion Criteria:

* A history of spine surgery or cervical injury
* Participated in a neck exercise program in the past three months
* Upper extremity problems
* Radiating pain, numbness, and weakness of the upper extremities
* A detectable pathological spinal condition
* Metabolic disorders, diabetes, and hypertension Obesity
The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery

The objective of this study will be to compare epidural infusion management, specifically looking at infusion rate changes, in patients who receive forceps deliveries versus normal spontaneous vaginal deliveries. We will match patients based on time and date of delivery, as well as parity, in order to eliminate these variables as potential con-founders.

We hypothesize patients who require a decrease in their basal labor analgesia epidural infusion rate will have an increased incidence of forceps delivery.

The obstetrical anesthesia database will be queried for all forceps deliveries between the dates of January 2004-October 2005. To minimize the influence of different anesthetic and obstetric care providers, the control group consisted of parturients who has spontaneous vaginal deliveries (SVD) in the same 24 hour period who were case-matched for gravidity and parity. Parturients with twin deliveries and fetal demise were not selected for either group.

The database will be queried for the following: maternal age, parity, gestational age, type of analgesia, changes in epidural infusion rate and/or concentration, and supplemental bolus doses of local anesthesia. The data will be stripped of identification by the database manager and entered into a secured computer which is password protected and maintained in the Department of Anesthesiology. The primary endpoint is to evaluate if decreasing the epidural infusion rate was associated with a forceps delivery.

Eligibility Criteria:
Inclusion Criteria:

* Singletons
* Viable fetal vaginal deliveries between January 2004-October 2005

Exclusion Criteria:

* Outside specified time frame
* Multiparity
* Fetal demise
Additional Benefit of Thoracic Impedance Monitoring (TIM) for Propofol-sedation Monitoring During PEG Placement

The present study is a randomized, prospective, single-blinded study. A total of 172 patients presenting for percoutaneous endoscopic gastrostomy (PEG) under sedation will be included according to the statistical sample size calculation. Patients will be randomized to either group 1- standard monitoring (pulseoxymetry and non-invasive blood preassure monitoring) or group 2- standard monitoring and thoracic impedance measurement during Propofol-based sedation for PEG. Episodes of Hypoxia are documented and compared in both groups.

Statistical analysis will be done in cooperation with the statistical biomedical institute oft he university hospital in Frankfurt.


Eligibility Criteria:
Inclusion Criteria:

* \> /= 18 years
* given consent
* planned PEG

Exclusion Criteria:

* ASA \>/= 4
* no given consent
* pregnant/laction
* contraindication against PEG
* contraindication against propofol-sedatation
Measurement of Renal Function With Iohexol in Subjects Ingesting Carnitine

The investigators will measure renal function in subjects ingesting carnitine to determine if the product alters renal function.


Eligibility Criteria:
Inclusion Criteria:

* carnitine ingestion

Exclusion Criteria:

* renal disease
Trajectory of Psychological Distress Among Infertility Women

Background: Infertility is a serious reproductive health issue and affects 48.5 million couples worldwide. Women undergoing fertility treatment often experienced psychological distress but also social stigma that is close linked to later pregnancy outcome. Despite the advancement in assisted reproductive technology, effective interventions for reducing stress, anxiety, and depressive symptoms for infertility women remain lacking.

Objectives: The objective of this proposal is to evaluate the efficacy of web-based mind-body intervention combining HRV biofeedback on the infertility women's anxiety symptoms, levels of depression, HRV function, mindful awareness, infertility self-efficacy, and pregnancy rates.

Methods: We plan to conduct a randomized controlled trial on the web-based mind-body intervention combining heart rate variability biofeedback. Eligible women will be recruited and randomized into three groups. Intention-to-treat analysis and mixed regression modeling will be used to estimate the effectiveness of the interventions.

Anticipatory results: Effective strategies will be determined for infertility women.

A designed data entry system for the current study will be developed to ensure an error-proof process. It is important to inspect data for outliers, wild code, and consistency to maintain the data quality in the pre-analysis data phase. We will assess the amount and pattern of missing values by using descriptive statistics, such as frequency and percentage. The pattern of missing data will be identified and decide whether the missing completely at random or not. The appropriate corresponding method will be adopted for the subsequent statistical analyses. For example, the mean imputation is considered when the percentage of items missing at a given questionnaire is less than 10 %. The mean imputation will be used to replaces a missing value with the item mean when applicable. The comparison between complete case analysis and imputation data will be performed to assess the reliability and validity of the results.

Eligibility Criteria:
Inclusion Criteria:

* 20-year-old and above
* Seeking infertility care
* Contemplating pregnancy
* Intended to start their ART cycle
* Able to speak Taiwanese or Mandarin

Exclusion Criteria:

* Diagnosis of cardiovascular disease, depressive disorder, anxiety disorder, cardiac arrhythmia
* Already had started their ART treatment
* Taking medications that might affect ANS activity
Treatment of Androgenetic Alopecia in Males

The purpose of this study is to evaluate the efficacy of the HairMax LaserComb 2009 7 Beam model in promoting hair growth in males diagnosed with androgenetic alopecia when treatment is applied as directed.

This is randomized, double-blind, control device clinical study across 2 sites, evaluating changes in terminal hair-count in the evaluation zone having evidence of androgenetic alopecia (miniaturized hair).

The trial will involve 45 male subjects who have been diagnosed with androgenetic alopecia, who are between 25 and 60 years of age, have Fitzpatrick Skin Types I-IV, with classifications of Norwood-Hamilton IIa to V, have active hair loss within the last 12 months.

Subjects will use the device on three nonconcurring days a week as directed per device for 26 weeks treatment duration.

Initial efficacy endpoint for each subject will be assessed at visit 4 (week 16).

Safety analysis will be assessed based on the reports of adverse events during study.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of androgenetic alopecia
* Fitzpatrick Skin Types I-IV
* Norwood-Hamilton IIa to V
* Active hair loss within last 12 months

Exclusion Criteria:

* Photosensitivity to laser light
* Malignancy in the target area