cyrilzakka/clinical-trials huggingface dataset:
Greater Houston Area Pediatric Bipolar Registry

The purpose of this study is to perform a comprehensive research assessment of children and adolescents who meet The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for Bipolar Disorder (BD) , offspring of a parent with BD, and healthy controls (HC), to obtain blood samples and saliva samples from each subject to allow the evaluation for BD biomarkers and genetic information, to notify participants about future research studies they may qualify for , to recommend follow-up with an outpatient provider if needed and to use magnetic resonance imaging (MRI) (structural MRI and diffusion tensor imaging) to investigate brain structures and relevant pathways associated with mood and behavioral regulation, conversion from softer forms of the BD spectrum (BD-NOS) to harder forms (BD-I and BD-II) and possible early identification.


Eligibility Criteria:
Inclusion Criteria for bipolar patients or offspring of bipolar parents:

* Any current mood state (in the case of bipolar subjects)
* For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
* For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult

Exclusion Criteria for bipolar patients or offspring of bipolar parents:

* Autism Spectrum Disorder (ASD)
* Developmental Intellectual Disorder
* Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
* Schizophrenia
* Uncontrolled or severe medical problem per investigator judgment
* For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability

Exclusion Criteria for healthy control subjects:

* Any Psychiatric Diagnosis
* Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative
* Any family history of a neurological condition in a first-degree relative.
* Mental Retardation/Intellectual Disability
* Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
* Schizophrenia
* Uncontrolled or severe medical problem per investigator judgement

Exclusion criteria for annual visits:

* Autism Spectrum Disorders (ASD)
* Intellectual Developmental Disorder
* Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
* Schizophrenia
* Uncontrolled or severe medical problem per investigator judgement
Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension

The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it

NGAL(Neutrophil Gelatinase Associated Lipocalin) is a 25KD protein which bounds with Gelatinase in Neutrophil granules.It is also expressed in epithelial cells of kidney tubules.NGAL increases in ischemic and toxic injuries of kidney. During controlled hypotension in brain operations injury to the kidneys might occur . This study is designed to assess this possibility and evaluate the effect of VitaminE+Selenium on prevention of this problem

Eligibility Criteria:
Inclusion Criteria:

* All patients who are candidate for brain surgery under controlled hypotension

Exclusion Criteria:

* Positive history of renal disease
* Positive history of diabetes mellitus, CHF, HTN, Breast cancer, fever, leukocytosis
Omega-3 Fatty Acid Supplementation to Enhance Performance

The goal of this intervention study is to determine if omega-3 fatty acid supplementation as compared to placebo improves performance in track and field athletes. The main questions it aims to answer are:

1. Can performance be improved
2. Can strength be enhanced
3. Will positive body composition changes occur (lean vs fat mass)
4. Will feelings of muscle soreness be diminished Participants will take either omega-3 fatty acid supplements or placebo and continue with their sport specific training regimen.

Researchers will compare the supplement group to placebo group to determine if there are any significant differences.

This is a randomized, placebo-controlled trial to determine the efficacy of fish oil-derived omega-3 fatty acid supplementation. Up to sixty participants will be randomized to receive one of two conditions: 4.0 grams of FO n-3/day or placebo (coconut oil) for the 10-week protocol study period. Nordic Naturals (Ultimate Omega) will be used as the intervention at a dose of 6 capsules/day (3840 mg total FO/1950 mg EPA/1350 mg DHA). Although protocols have varied among studies with regards to dosage, the proposed regimen was selected based on studies on strength in older adults and college-aged athletes utilizing a range of 2-5g FO n-3 per day. Blinded randomization will be accomplished with a research associate providing every first (of two) participants the placebo, while the second will receive the supplemented condition until recruitment is complete. Participants will be provided their supplement in 2-week increments and instructed to consume with/near their evening meal. Used bottles will be returned after two weeks and participants will receive the next 2-week supply of supplement and the leftover pill count will determine compliance rate.

The target population is apparently healthy college athletes (male and female of all ethnicities) between the ages of 18-25 years at Baylor University. Participants must be able to read and understand English and sign their own consent form. Up to 60 subjects will be recruited via direct contact or team briefings with permission of the coaches.

Eligibility Criteria:
Inclusion Criteria:

Apparently healthy college athletes (male and female of all ethnicities) between the ages of 18-25 years.

Exclusion Criteria: -Participants will be excluded if they are unable to physically train due to injury/illness or are pregnant, or have a known heart condition or pacemaker.
Immune-modulatory Effect of Probiotic Strain on Grass Pollen Allergic Individuals

The purpose of the current study is to evaluate the effect of administering a probiotic strain on allergic symptoms and immune parameters (Th-2 cytokines, effector cells) in seasonal allergic rhinitis subjects.

To identify immune markers in allergic individuals that are impacted by probiotic treatment during seasonal exposure

Eligibility Criteria:
Inclusion Criteria:

* Confirmed allergy (allergic rhinitis) to grass pollen \> 1 year and positive SPT \> 3mm wheal diameter to grass pollen.
* Age 20-65 years adults
* Body Mass Index 19- 29 (people in the normal and overweight range)
* Having obtained his/her informed consent.

Exclusion Criteria:

* Anemia
* Family history of congenital immunodeficiency
* Regular consumption of immunosuppressive or anti-inflammatory treatment
* Under medication against allergy (e.g. anti histaminic)
* Avoid regular consumption of probiotic and other dietary nutritional interventions
* Have a high alcohol consumption (more than 1 drink/day)
* Consumption of illicit drugs
* Pregnancy

  * Subject who cannot be expected to comply with the study procedures, including consuming the test products
  * Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study
Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma

The investigators hypothesize that there is a statistically significant decrease of Natriuretic Hormone Peptides (NHPs) in subjects with asthma exacerbation compared to levels following treatment of an exacerbation of asthma.

Overall Study Design

1. Measurement of Natriuretic Hormone Peptides in individuals suffering from exacerbation of asthma.
2. Measurement of Natriuretic Hormone Peptides 5-7 days after initiation of treatment of exacerbation of asthma.
3. Measurement of Natriuretic Hormone Peptides 10-14 days after initiation of treatment of exacerbation of asthma.

3 comparisons of Natriuretic Hormone Peptides levels will be made:

1. Exacerbation compared to 5-7 days after initiation of treatment
2. Exacerbation compared to 10-14 days after initiation of treatment
3. 5-7 days after initiation of treatment compared to 10-14 days after initiation of treatment.

Samples of blood will be secured in the Division of Allergy/Immunology at the University of South Florida, Joy McCann Culverhouse Airways Disease Center. All samples will be appropriately coded to maintain confidentiality. Blood specimens will be held at minus 20 degrees Celsius.

Eligibility Criteria:
Inclusion Criteria:

* Both genders, age 18-85.
* Females who are pregnant or lactating are not eligible.
* Read and comprehend English.
* Ability to give informed consent.
* Seen in the outpatient setting at one of the clinic.
* The subject must have a history of physician diagnosed asthma for at least 1 year and must have an exacerbation of asthma for entry into the study.
Milk Biofortification Promotes Health Benefits in Institutionalized Elderly

The project aims to study the effects of inclusion of sunflower oil, vitamin E and selenium in the diet of dairy cows on milk composition and the influence of modified milk on nutrition and health of elderly. To achieve those goals, two experiments will be conducted, both lasting 12 weeks. In the first one, 32 cows at the beginning of lactation will be allotted in a completely randomized block design with a 2 x 2 factorial arrangement of treatments, as follow: 1) control diet; 2) control diet plus selenium and vitamin E; 3) control diet plus sunflower oil diet; 4) control diet plus sunflower oil, selenium and vitamin E. This experiment seeks the development of modified milks through nutritional manipulation of cow's diet. Concomitantly, in the second experiment, 132 elderly people will receive the four different kinds of milk produced in the first experiment in a completely randomized block (gender) design. The selection of the elderly for each group shall be composed clinical evaluations. Will be conducted biochemical tests before and after supplementation of milk consumption (serum α-tocopherol, selenium, analysis of fatty acid profile). Assessment of nutritional status will be made body mass index (BMI) with each participant before and after the experiment of 12 weeks, including body composition by multifrequency bioelectrical impedance analysis (BIA), evaluating the strength of pressure of the hand portable dynamometer, demographics and food consumption. The study of human nutrition and health will be held in the form of a double-blind study. The second experiment aims to study nutrition and health of elderly people, as it is expected that milk produced with better fatty acid profile, vitamin and minerals can improve the inflammatory profile of markers of the elderly. This project is important for the human population in general, particularly elderly people, health workers, human and animal nutritionists, and especially for the milk chain, as it has a potential to develop new dairy products and boost milk consumption.


Eligibility Criteria:
Inclusion Criteria:

* Any institution residents that use milk in their usual diet.

Exclusion Criteria:

* Inability to drink
* Use of enteral diets
* Lactose intolerance
* Autoimmune disorders
* Infections, allergies or inflammation in the two weeks prior to blood collection.
Babies' Expectations About Racial Interactions

This study will examine whether infants view race as an inductively useful social cue to predict third-party social relationships.

Based on findings that infants expect more affiliation between same language speakers than different language speakers (i.e., infants will look longer at affiliation between different language speakers than same language speakers), this study will assess whether infants' expectations about intra- and inter-racial interactions will also follow the same pattern as language. After informed consent, participants who meet the eligibility requirements will be randomized into one of the 3 conditions: Watching (1) two White adults affiliating and disengaging, (2) two Black adults affiliating and disengaging, and (3) one White and one Black adults affiliating and disengaging.

Eligibility Criteria:
Inclusion Criteria:

* full term (at least 37 weeks at birth)
* no known developmental delays

Exclusion Criteria:

* not full term (less than 37 weeks at birth)
* known developmental delays
Prevalence of Cutaneous Enterococci at Femoral Insertion Site in Transcatheter Aortic Valve Implantation (TAVI)

The general rules of antibiotic prophylaxis in surgery or interventional medicine include the choice of an antibiotic active on the bacteria most frequently encountered in surgical site infections. This antibiotic must cover, the bacteria present on the skin and recognized as responsible for surgical site infections.

The aim of this study is to identify bacteria found in skin flora in the inguinal region of patients undergoing Transcatheter Aortic Valve Implantation (TAVI). Flora found will allow to evaluate the impact of skin preparation and antibiotic prophylaxis protocols as they are currently practiced.


Eligibility Criteria:
Inclusion Criteria:

* Patient scheduled for aortic valve replacement by TAVI procedure with trans femoral approach
* Patient with pre-TAVI assessment performed at Clinique Pasteur
* Patient affiliated or beneficiary of a social security scheme
* Patient accepting to participate and having given his no objection

Exclusion Criteria:

* TAVI procedure by non-trans femoral approach
* Protected patients: Adults under guardianship or other legal protection; Pregnant or breastfeeding woman; Hospitalized without consent.
Study on the Appropriateness of Bariatric Surgery in Adolescents

single-center study carried out in order to evaluate in prospective among patients seen or treated in the pediatric endocrinology unit and multidisciplinary management of obesity, the potential number of patients eligible for surgery.

This is a feasibility study in order to file a subsequent national project as part of a PHRC on bariatric surgery in adolescents.

Eligibility Criteria:
Inclusion Criteria:

* failure of weight loss in an organized care\> 6 months
* BMI \> à 35 kg/m2 with presence of severe co-morbidities (diabetes, moderate or severe OSAS, intracranial hypertension, severe hepatic steatosis), which can be improved by a significant weight loss and sustainable OR BMI \> or = 40 kg/m2 with less severe co-morbidities (hypertension, GERD) and may worsen the health status including reduced quality of life.
* Patients must have completed their growth (bone age \> 13 for girls and \>15 for boys).
* The teenager and his legal representative must have given their informed consent.
* The subject must be affiliated to a social security scheme

Exclusion Criteria:

* syndromic obesities
* tumor-induced obesity
* Patient with severe psychiatric disorders
* Patient with eating disorders
* Patients under judicial protection
* Patient under guardianship or curatorship
* Patient participating in another study
A Research on the Hospital Pollution Control and Hygine Intervention of Chemotherapy Drugs Exposure

Several epidemiological studies found that exposure to antineoplastic agents were associated with some reproductive, carcinogenic effects, higher rates of advance micronuclei (MN), sister-chromatic-exchange (SCE) and spontaneous abortion. Cleaning staff were potentially exposed to these agents while cleaning ward, ward toilet or other area.

One medical center and one area hospitals in Taipei.Surface wipe samples were collected in the cleaning staff work area, such as ward environment and ward toilet. Urine and blood samples of subjects were collected for exposure examinations. Platinum-containing drugs (Cisplatin, Carboplatin, Oxaliplatin) were used as indicator drugs in environmental (surface wipe samples) and biological (urine and blood samples) samples.

A self-administered questionnaire was used to collect demographic data, working practices, medical and contact history, and perceived work-related symptoms of cleaning staff.

The results of this study will be to reduce exposure to cleaning staff.


Eligibility Criteria:
Inclusion Criteria:

* Only included those who signed the consent study

Exclusion Criteria:

* none
Role of Ultrasound Imaging in Diagnosis of Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood and an important cause of acquired disability in children . Despite the heterogeneity, all forms of JIA are characterized by prolonged synovial inflammation that can cause cartilage and bone damage, with severe impairment of physical function and impact on the quality of life. The presence of joint involvement in JIA may be expressed by ultrasonography findings such as synovial proliferation, effusion, cartilage thinning and bone erosions. US has demonstrated higher sensitivity in detecting synovitis compared to clinical examination MSUS is commonly regarded as a very useful tool in children, as outlined by the results of recent national and international surveys among pediatric rheumatologists .For most of the respondents, MSUS owned particular relevance for the ability to detect subclinical synovitis and to improve the classification of patients in JIA subtypes, as guidance to intraarticular corticosteroid injections and for capturing early articular damage. In addition, some specific joints were considered as most suited to be studied by MSUS, specifically the midfoot, the ankle, the hip, the wrist, the small joints of hands and feet. .

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood and an important cause of acquired disability in children . Despite the heterogeneity, all forms of JIA are characterized by prolonged synovial inflammation that can cause cartilage and bone damage, with severe impairment of physical function and impact on the quality of life. The presence of joint involvement in JIA may be expressed by ultrasonography findings such as synovial proliferation, effusion, cartilage thinning and bone erosions. US has demonstrated higher sensitivity in detecting synovitis compared to clinical examination MSUS is commonly regarded as a very useful tool in children, as outlined by the results of recent national and international surveys among pediatric rheumatologists .For most of the respondents, MSUS owned particular relevance for the ability to detect subclinical synovitis and to improve the classification of patients in JIA subtypes, as guidance to intraarticular corticosteroid injections and for capturing early articular damage. In addition, some specific joints were considered as most suited to be studied by MSUS, specifically the midfoot, the ankle, the hip, the wrist, the small joints of hands and feet. .

Eligibility Criteria:
Inclusion Criteria:

* Age between 1-17 years only.
* Both sexes.
* children with any type of Juvenile Idiopathic Arthritis

  -Exclusion criteria
* Age above 17years.
* Children with arthritis of known cause.
Efficacy of 200 IU OnabotulinumtoxinA in Idiopathic Overactive Bladder Resistant to Anticholinergic Treatment

This study aimed to assess the efficacy and safety of onabotulinumtoxinA (botulinum toxin type A) in patients with idiopathic overactive bladder (OAB) and urinary incontinence who had previously failed to respond to anticholinergic treatment. Additionally, we examined the impact of significant reductions in bladder wall thickness on therapeutic outcomes.

The efficacy of OnabotulinumtoxinA was investigated in patients who attended urology outpatient clinics between January 2016 and June 2022 for overactive bladder unresponsive to anticholinergic therapy. Baseline symptoms and quality of life data were compared to those at month 6 after the treatment. The voiding diary (for 3 days) of each patient was reviewed to assess and record patients' symptoms. Baseline ultrasound (US)-measured post-void residual urine (PVR) and bladder wall thickness (BWT) values were recorded. Patients with a history of neurological disorders, anticholinergic-naive patients, patients diagnosed with bladder cancer, and those with bladder outlet obstruction were excluded from the study.

Eligibility Criteria:
Inclusion Criteria:

* overactive bladder urge incontinence

Exclusion Criteria:

* neurological and/or neurosurgical disorders, anticholinergic-naive patients, bladder cancer, bladder stone, interstitial cystitis, prostate cancer chronic prostatitis bladder outlet obstruction
Impact of Alpine Dairy Products on Blood Lipid Levels

Elevated blood lipid levels are one of the main risk factors for cardiovascular disease. To manage elevated blood lipid levels in otherwise healthy people at low risk of cardiovascular disease, lifestyle changes are recommended as the first treatment strategy. One of these changes concerns diet. Clinical observations by general practitioners in alpine regions of Switzerland have shown that consumption of dairy products produced from cows living and grazing at high altitudes can have a beneficial effect on blood lipid parameters. However, little clinical data is available on the effect of alpine dairy products on health-related markers. This pilot study aims to assess if replacing standard (non-alpine) dairy products by alpine dairy products in the daily diet among patients with elevated LDL-cholesterol levels could reduce the blood LDL-cholesterol levels.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years old
* Elevated lipid levels, namely: fasting LDL-cholesterol \>3mmol/L and \</=5mmol/L
* Agreeing to eat 3 portions of dairy products daily (according to instructions)

Exclusion Criteria:

* Eating less than two and more than six portions of dairy products daily
* Body weight change +/-5% of body weight in the last three months
* Secondary prevention treatment for cardiovascular disease
* Moderate, high or very high cardiovascular risk according to AGLA score
* Currently taking PSCK9-inhibitors, ezetimibe, statins, glucocorticoids
* Poorly controlled, severe chronic renal insufficiency, hypothyroidism, cholestasis, nephrotic syndrome, eating disorders, alcohol abuse, Cushing syndrome
* Myocardial infarction, percutaneous coronary intervention or coronary artery bypass grafting in the previous 6 months
* Known lactose intolerance or dairy allergies
* Change of diet less than 2 months before intervention
* Pregnant or breastfeeding
* Incapacity of judgement
* Inability to speak and read German