cyrilzakka/clinical-trials huggingface dataset:
The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients with Compensated Cirrhosis

The goal of this clinical trial is to explore the impact of a 16-week aerobic exercise regimen on the autonomic nervous system and endothelial function in patients with compensated cirrhosis who have physical inactivity. The primary research question is:

1) What effect does 16 weeks of aerobic exercise have on changes in the autonomic nervous system and endothelial function in cirrhotic patients?

Additionally, the secondary research questions are:

1. How does a 16-week aerobic exercise program influence changes in muscle mass, muscle strength, and physical performance in cirrhotic patients?
2. Is there a correlation between muscle mass and parameters of the autonomic nervous system in cirrhotic patients?

Participants in the intervention group will undergo 150 minutes of moderate aerobic exercise per week for 16 weeks, accompanied by a personalized nutritional plan (1.2 grams of protein per kilogram of ideal body weight per day and a calorie intake of 35 kilocalories per kilogram of ideal body weight per day). The control group will solely receive nutritional guidance and maintain their physical inactivity. The researchers will compare outcomes between these two groups.


Eligibility Criteria:
Inclusion Criteria:

* The diagnosis of cirrhosis is confirmed either through liver biopsy ,and/or compatible features on ultrasonography/ computer tomography or magnetic resonance imaging.
* The age range is between 45 and 75 years.
* Participants are classified as Child Pugh score class A.
* Participants report a physical inactivity, defined as engaging in physical activity for less than 150 minutes of moderate-intensity physical activity per week, or less than 75 minutes of vigorous-intensity physical activity per week, or an equivalent combination of both.

Exclusion Criteria:

* Active hepatocellular carcinoma (HCC) or remission of HCC within the past 3 months.
* Untreated large esophageal varices (EV) greater than F2 or history of upper gastrointestinal bleeding from portal hypertension or gastric varices.
* Active or history of hepatic encephalopathy (HE).
* Inpatient hospitalization for any reason or discharge from the hospital within the past 3 months.
* Complete portal vein thrombosis.
* Transjugular intrahepatic portosystemic shunt.
* Contraindications to exercise, such as recent myocardial infarction, unstable angina, electrocardiography changes within the past 24 hours, complete heart block, acute congestive heart failure, uncontrolled hypertension, hemoglobin level less than 11 g/dL, platelet count less than 50,000 cells/mm 3 .
* End-stage renal disease without dialysis.
* Severe orthopedic problems that limit the ability to exercise.
* Inability to communicate with the research team via telemedicine system.
* Body mass index (BMI) exceeding 35 kg/m 2 .
* On alpha or beta-blocker
Sedation Regimen in Patients Undergoing Cardiac Electrophysiology Study and Ablation : a Comparison Between Dexmedetomidine-remifentanil and Midazolam-remifentanil Combinations

Cardiac ablation is an invasive procedure requiring anesthetic support for immobility and analgesia. Benzodiazepines and opioids are the most commonly used agents, while they are associated with respiratory depression and hypotension. The aim of this study was to compare the effect of remifentanil and dexmedetomidine, which exerts sedative and analgesic effect without serious respiratory depression, with conventional midazolam/remifentanil combination on sedative and analgesic levels in patients undergoing endocardial ablation.


Eligibility Criteria:
Inclusion Criteria:

* patients scheduled for elective cardiac ablation for atrial fibrillation

Exclusion Criteria:

* ASA physical status class ≥ 3,
* respiratory disease,
* end stage renal disease,
* illiterate
Muscular Morphological Ultrasound Epidemiological Study in Dance Professionals

This research will determine the presence of groin pain in professional dancers, through a specific questionnaire on the hip joint. Two groups will be formed made up of dancers over 18 years of age, men and women; one with groin pain and one without groin pain. All participants will undergo a functional muscle ultrasound study, where the thickness of the abdominal muscles, lumbar multifidus and gluteus medius and minor will be evaluated, and the relationship between ultrasound neuromuscular changes and groin pain will be verified

The objective of the study is to shed light on the to the complexity of the Diagnosis that Groin Pain (GP) encloses, it is proposed to evaluate with Functional Muscular Ultrasonography Rehabilitative Ultrasound Imaging (RUSI), the layer thickness of the gluteal musculature of the hip and the abdominal and lumbar muscles on a sample of professional dancers over 18 years of age with GP to check if there are differences with professional dancers without GP.

Expected goals:

1. Identify the presence of GP in professional dancers.
2. To compare the ultrasound characteristics of the neuromuscular system between a sample of dancers with GP and a sample of dancers no GP.
3. Verify the relationship between ultrasound neuromuscular changes with GP.

Eligibility Criteria:
Inclusion Criteria:

* Volunteer Professional dancers 18 years or older, and no maximum age limits

Exclusion Criteria:

* Not signing the informed consent
Virtual Reality: a Teaching-learning Strategy for Cognitive Mastery in Airway Trauma Management

Airway injury in patients is a high risk and complex medical crisis. Unfortunately, training for airway management in injured patients is challenging. The most effective way of practicing airway management is using mannequins. However, mannequin training is expensive and only occasionally available to medical trainees.

The purpose of this study is to determine if Virtual Reality (VR) can be used to educate medical students on airway injury management. VR training will involve managing the care of a patient with an airway injury in an immersive, interactive VR hospital trauma bay. The investigators will compare the knowledge gained from VR training vs. mannequin training. The investigators will also investigate whether VR training teaches students faster than mannequin training. In addition, the investigators will identify factors which might affect learning from VR.

Medical students who choose to participate will be randomized (i.e. participant will have a 50% chance to be placed in either group) to be trained with VR or a mannequin. Participants then will be trained on airway injury management using their assigned training approach. One week later, all participants will be assessed on their airway injury management skills using a mannequin. Before and after their sessions, participants will also be asked to complete a questionnaire on their clinical decision-making. Participants who received VR training will also complete a questionnaire about their experience with the VR training.

This study will help develop a new approach to airway management training which is cheaper and more easily available to medical trainees than mannequin training. This educational tool could lead to better treatment of airway trauma in future patients.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 at time of consent
* Medical student at U of T in 1st, 2nd or 3rd year
* Able to attend two sessions a week apart

Exclusion Criteria:

* Lack of participant consent or capacity to give consent
* History of significant motion sickness (during exposure to physical, visual and virtual motion, cybersickness verbally declared by patient)
* Visual/hearing impairments that affect abilities to listen/watch videos/VR video
Exercise Response After Revalidation in Cancer Patients

This study regarding oncological patients for rehabilitation after specific cancer therapy involves three aims: (1) to evaluate the predictive value of myocardial work parameters on the improvement of exercise performance after rehabilitation, (2) to determine which echocardiographic parameters are more suitable in predicting cardiac dysfunction, and (3) to evaluate the correlation between echocardiographic parameters and fibrosis detected by cardiac magnetic resonance imaging (CMR).

Myocardial work (MW) provides an estimation of cardiac function by combining global longitudinal strain (GLS) with blood pressure values obtained non-invasively, being less load dependent than standard GLS. The investigator hypothesize that myocardial work could be a useful marker for predicting the exercise performance after chemotherapy and/or radiotherapy in oncological patients undergoing rehabilitation. Moreover, this study may provide additional information in optimal selection for rehabilitation programs.

Eligibility Criteria:
Inclusion Criteria:

1. Patients diagnosed with cancer
2. Undergoing chemotherapy and/or radiotherapy/hormone therapy
3. Age older than 18 years old - maximum age of 90 years old
4. Willing to enter revalidation in Universitair Ziekenhuis Brussel
5. Signed consent form

Exclusion Criteria:

1. Severe aortic stenosis defined as aortic valve aria under 0.6 cm2/m2
2. Supraventricular arrhythmias
3. Poor image quality for 2D and 3D echocardiography defined as the impossibility to examine of more than 2 adjacent segments
4. Resistant hypertension defined as uncontrolled blood pressure values under current European guidelines, Systolic Blood Pressure more than 140 mmHg and/or Diastolic Blood Pressure more than 80 mmHg
5. Lung cancer
Effect of Relaxing Music on Blood Pressure and Resting Heart Rate

Prehypertention is defined as systolic blood pressure between 120 and 139 mmHg and/or diastolic blood pressure between 80 and 89 mmHg. People with prehypertension have the higher risk to develop hypertension compared to people with normal blood pressure (normotensive) especially when getting old, therefore prehypertension is known for preliminary stage of hypertension. Framingham Heart Study have shown the progression rate from prehypertension to hypertension was as high as 19% over 4 years. Prehypertension will also lead to abnormality of the cardiovascular system. Thus it is very important to identify the prehypertension at early stage, so that steps can be taken to slow down the progression to hypertension and to normalize the blood pressure level. Minimal reduction in blood pressure produce a large benefit to human health, as stated in JNC (Joint National Committee) VII report, a 5mmHg decrease in systolic blood pressure would be able to reduce as much as 9% mortality rate caused by coronary heart disease, 14% mortality related to stroke, and 7% decrease in all-cause mortality. Previous studies have focused on effect of music therapy in hypertensive elderly, prehypertensive pregnant women, prehypertensive elderly but no research has been conducted on prehypertensive young adults. In addition, prehypertension increase risk of developing cardiovascular disease, thus early intervention is needed to prevent the progression of prehypertension to hypertension status and normalize the blood pressure level.

Quota sampling will be used as the sampling method. Investigators would recruit 30 participants for this study.

Eligibility Criteria:
Inclusion Criteria:

* Systolic blood pressure between 120 to 139 mmHg
* Diastolic blood pressure between 80 to 89 mmHg
* Not having any hearing impairment and able to listen to music using headphone
* Willing to participate in this study

Exclusion Criteria:

* Under influence of any medication that would affect the concentration
* Systolic Blood pressure of less than 120 or more than 140 mmHg
* Diastolic blood pressure of less than 80 or more than 90 mmHg
Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee

A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of RTX-GRT7039 versus placebo in patients who have pain associated with osteoarthritis of the knee despite standard of care.

This trial comprises a total observation period of up to 52 weeks.

Eligibility Criteria:
Inclusion Criteria:

* The participant has given written informed consent to participate.
* The participant is 18 years of age or older at the Screening Visit.
* The participant has a diagnosis of osteoarthritis of the knee based on American College of Rheumatology criteria and functional capacity class of I to III.
* There is a documented history indicating that participant has insufficient pain relief with previous Standard of Care.

Exclusion Criteria:

* The participant has past joint replacement surgery of the index knee.
* The participant has a history of significant trauma or surgery (e.g., open or arthroscopic) to the index knee within 12 months of Screening.
* The participant has periarticular pain from any cause other than osteoarthritis, including referred pain, bursitis, or tendonitis.
* The participant has clinical hip osteoarthritis on the side of the index knee.
* The participant has pre-existing osteonecrosis, subchondral insufficiency fracture, atrophic osteoarthritis, severe bone on bone osteoarthritis, knee pain attributable to disease other than osteoarthritis, or the participant has rapidly progressing osteoarthritis (RPOA) Type I or Type II.
* The participant has significant malalignment of anatomical axis (medial angle formed by the femur and tibia) of the target knee (varus \>10, valgus \>10) by X-ray as assessed by independent Central Readers at Screening Visit.
* The participant has other conditions that could affect trial endpoint assessments of the index knee.
* The participant has current clinically significant disease(s) or condition(s) that may affect efficacy or safety assessments, or any other reason which, in the investigator's opinion, may preclude the participant's participation in the full duration of the trial.
* The participant has a history of hypersensitivity to resiniferatoxin (RTX) or any similar component (capsaicin, chili peppers).
* The participant is currently participating or was participating in another investigational drug trial within 3 months prior to the Screening Visit.
* The participant is an employee of the investigator or trial site, with direct involvement in the proposed trial or other trials under the direction of that investigator or trial site or is a family member of the employees or the investigator.
Non-steroidal Anti-inflammatory Drugs in Pleurodesis

Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence.

The investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.


Eligibility Criteria:
Inclusion Criteria:

* Age≥18-year-old
* pneumothorax with an indication of pleurodesis
* with or without minimal lung resection
* via thoracotomy or thoracoscopy

Exclusion Criteria:

* Minor patient
* Pregnant, parturient or breast-feeding patient
* Severe polytrauma (associated with the presence of a Vittel criterion)
* Purulent pleurisy
* Hemopneumothorax
* Lactose hyper sensibility
* Contraindications to NSAID
* Contraindications to tramadol
* Contraindications to paracetamol
* Curative anticoagulation
* Patients under guardians or deprived of their liberty
* Patient refusal
Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

This is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions.

PRIMARY OBJECTIVE: To perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising in giant nevi).

SECONDARY OBJECTIVE: To collect minimal information on patients treated with adjuvant or systemic therapies according to National Comprehensive Cancer Network (NCCN) guidelines.

Investigators will study the DNA and RNA in tumor cells and blood cells to look for changes that may be related to the development of the tumor, as well as changes that may influence how the tumor responds or doesn't respond to treatment. Normal blood cells will be studied to compare to the tumor cells. Investigators will also look at basic information about the treatment received and how the tumor responds, i.e. what kind of chemotherapy, surgery, radiation treatment, or other therapy the participant received, whether they had serious side effects, and how well the tumor responded to the treatment.

As part of regular medical care, tumor will be obtained to determine the type of cancer. For participants who consent to this study, leftover tumor tissue not needed for diagnosis or regular medical care will be studied at St. Jude Children's Research Hospital where scientists will look for changes in the genes of the tumor cells. No additional surgeries or procedures are needed for this study. A small amount of blood (2-3 tablespoons) will be collected and analyzed to determine if the genetic changes in the tumor cells are also found in the blood cells. Small children (\<42 lbs.) will have a smaller amount drawn (1-2 tablespoons).

Eligibility Criteria:
Inclusion Criteria:

* Participant has a suspected or confirmed diagnosis of a melanocytic lesion, including:

  * Conventional or "adult-type" melanoma
  * Spitzoid melanoma/atypical Spitz tumor
  * Congenital melanoma
  * Melanoma arising in a giant congenital nevus
  * Melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas)
* Participant was \<19 years of age at the time of diagnosis.
* Tissue is available for biologic studies.
* Participant has been enrolled on the TBANK protocol at SJCRH, or will be enrolled before any research tests are performed on their biological materials.

Exclusion Criteria:

* Ocular melanoma
* Inability or unwillingness of research participant or legal guardian to consent.
* Histologic diagnosis other than melanocytic lesion described in 3.1.1.
Safety and Efficacy of Drug Combinations Against Triple Infections

This randomised, controlled, double blinded clinical study investigates the safety and efficacy of the combination of albendazole, ivermectin and praziquantel in the treatment of children aged 5-18 years co-infected with lymphatic filariasis, schistosomiasis and soil-transmitted helminthiasis.


Eligibility Criteria:
Inclusion Criteria:

* Those who will be in class one to six by the time of study
* Aged 5-18 years and found infected with either SCH, any STH or LF for treatment groups 1,2 or 3 or infected with both SCH and LF for treatment group 4 and infected with all the three for treatment group 5
* Who are willing and consent and whose parents will consent, will be included in the study.

Exclusion Criteria:

* Those with acute and chronic diseases other than the targeted infections and those with a history of any serious adverse drug reactions will not be included in the study.
* Children with total bilirubin \> 50µmol/L and ALAT (Alanine transferase) \> 70IU/L will not qualify for recruitment.
The Effect Of Lullaby Records Sung By The Parent's During Newborn Care On Newborn's

Standard nursing care including, eye, mouth, nose, diaper change, skin care with baby oil and nurturing was applied respectively to the study groups for approximately 20 minutes. The baby was made listen to the lullaby recorded in the voice of parents starting with, during and after the care for 10 minutes. Heart rate, saturation, respiration rate and comfort behiavour scores of the newborn was measured 1 minutes before, during and 15 minutes after the care. The data was evaluated in SPSS 21.0 program with convenient statistical methods.İt is detected that heart rate, respiration rateand comfort behiavour scores of the newborns who listen to lullaby in the mother's voice are low compared to the newborns listening to lullaby in the father's voice and those in the control group .


Eligibility Criteria:
Inclusion Criteria:

* Premature babies at 30-37 weeks of gestation,
* There is no congenital anomaly affecting respiration and spontaneous respiration,
* No intubation,
* Absence of congenital or acquired malfarmation related to hearing,
* Absence of hyperbilirubinemia requiring exchange transfusion,
* Absence of intrauterine infection (rubella, syphilis, toxoplasma),
* Absence of intracranial bleeding,
* No sedative, opioid and anticonvulsant drugs were given before/during the study,
* Parents' consent to participate in the study,

Exclusion Criteria:

* Having a diagnosis of asphyxia,
* Congenital hearing problems in family members,
* Intubating the baby after starting the research,
* Parents have a speech impediment,
* Parents have psychological problems,
The Effect of a Deep-fried Chocolate Bar or Porridge on Cerebral Blood Flow

The deep fried chocolate bar is a snack that the international community strongly associates with Scotland. It has previously been cited as being "a symbol of all that is wrong with the high-fat, high-sugar Scottish diet". Despite the snack's reputation, no medical research has been performed to examine the effects of consuming a deep fried chocolate bar on the human body.

In contrast to the deep fried chocolate bar, porridge has been shown to reduce the risk of cardiovascular disease, but its effect on cerebral blood flow has yet to be directly assessed.

This study will focus on the potential (patho)physiological cerebrovascular effects of the deep fried chocolate bar and porridge. The research question to be addressed in this study is "Does eating a deep fried chocolate bar or bowl of porridge induce changes in cerebral blood flow and cereborvascular reactivity in healthy adults?"

To assess the acute effects on eating either food on blood flow through the largest artery in the brain, the investigators will give healthy volunteers one regular-sized deep-fried chocolate bar or a bowl of porridge. Blood flow through the largest artery in the brain will be assessed using simple ultrasounds tests. The investigators aim to recruit 24 volunterrs who will visit twice, consuming a different food on each visit.


Eligibility Criteria:
Inclusion Criteria:

* BMI between 18 and 30
* No regular medication
* Able to provide informed consent

Exclusion Criteria:

* Distaste for or contraindication to deep-fried chocolate bar or porridge ingestion
* inability to perform breath-hold