cyrilzakka/clinical-trials huggingface dataset:
Oblique Subcostal Tap Block Efficacy in Laparoscopic Cholecystectomy

Laparoscopic cholecystectomy although a minimally invasive procedure, may be accompanied by considerable pain after surgery. More recently transversus abdominis plane (TAP) block was extensively studied as a potential analgesic maneuver after laparoscopic cholecystectomy. The subcostal approach (OSTAP block) is a variation on the TAP block that produces reliable supraumbilical analgesia.

Laparoscopic cholecystectomy is a minimally invasive widespread surgical procedure, with postoperative lower pain scores and quick recovery of the patient. However some of patients may complain of considerable pain after surgery . There are several approaches to postoperative pain management after laparoscopic cholecystectomy such as patient-controlled analgesia with opioids (IV-PCA), neuraxial blocks, intraperitoneal injection of local anesthetics, wound infiltration, each being more or less effective, with specific side effects.

The transversus abdominis plane block (TAP-Block) is a regional analgesia technique that comes as an alternative to "classical" procedures of postoperative analgesia. Described by Rafi and McDonnell et al. this technique has undergone some changes over times, which increased its efficiency. Thus, Hebbard et al. described ultrasound subcostal oblique approach (OSTAP) of the block allowing analgesia in both the upper and lower abdomen, with a lower rate of complications due to the direct ultrasound visualization. Different studies confirmed the analgesic efficacy of this technique and the postoperative opioid sparing effect after laparoscopic cholecystectomy .

Traditionally, the transversus abdominis plane block is achieved with classical amino-amides local anesthetics, bupivacaine, levobupivacaine and ropivacaine being the most commonly used .

Based on the local anesthetic properties of pethidine, a synthetic opioid, our study aimed to evaluate prospectively the analgesic efficacy of pethidine in achieving transversus abdominis plane block by ultrasound oblique subcostal approach in patients scheduled for elective laparoscopic cholecystectomy.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anaesthesiologists (ASA) I-II
* Age over 18years old
* patients scheduled elective laparoscopic cholecystectomy

Exclusion Criteria:

* Open cholecystectomy - excluded due to increased levels of pain in open procedures
* Renal dysfunction (Serum Cr \> 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications
* Coagulopathy or anticoagulation - increased risk of bleeding from nerve block injection
* Allergy or contraindication to any of the study medications or anesthetic agents
* Chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone
* Patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder)
* Pregnancy
* Prisoners
* Patient or surgeon refusal
HEAlth Dialogues for Patients With Mental Illness in Primary Care

In the current project, primary health care patients with mental illness such as anxiety, depression, fatigue or sleep disorders will be followed. The study includes both health conversations with the health curve as a systematic work with lifestyle habits, and the biochemical risk marker copeptin with a focus on improved lifestyle habits and the development of cardiovascular complications. Participants will be followed up at 12 and 24 months with renewed health interview including the health curve and blood sampling. National registries will be used for a, up to 20 year long follow-up regarding cardiovascular complications and mortality.

Patients with mental illness have an increased risk of cardiovascular morbidity and mortality compared to the rest of the population, partly related to unhealthy lifestyle habits. However, not all risk factors for developing cardiovascular disease are known yet. The interest in studies about the importance of copeptin as a biochemical risk factors has increased in recent years.

Objectives:

The main aim with this project is assessment of the effect of Health Dialogue with the health curve (in swedish; Hälsokurvan) on lifestyle habits and cardiovascular risk factors in patients with mental illness in primary care. The second aim is to assess copeptin's prognostic value and to collect blood samples in a biobank for future research on molecular biomarkers with prognostic value for cardiovascular disease.

Work plan:

The study has a prospective observational design. The method with Health Dialogues is previously validated in a Swedish context and is based on a detailed lifestyle questionnaire, blood testing and personalized counselling by a trained health care professional. The patients will be followed with a new Health Dialogue and blood samples after 12 and 24 months and for 20 years with National Registers

Significance:

The effect of Health Dialogues in patients with mental illness is not studied yet. The current fast implementation of the method in the primary care in south of Sweden (the region of Scania) provides a unique opportunity to study this patient group and the expected benefits of Health Dialogues in the long term, to study a potentially useful risk biomarker (copeptin) as well as to build a biobank for future studies on cardiovascular prognostic risk markers.

Eligibility Criteria:
Inclusion Criteria:

* patients \> 18 years old seeking primary care for mental illness (depression, anxiety, sleep disorders or stress related problems

Exclusion Criteria:

* Dementia, not speaking, writing or understanding spoken the Swedish language.
Treat Autosomal Dominant Polycystic Kidney Disease With Oral Ketone Ester?

The investigators are running a study to see if a special drink, called a "ketone ester", can help people with a type of kidney disease named "Autosomal Dominant Polycystic Kidney Disease" or ADPKD for short.

The investigators want to find out:

If it's easy for patients to take this drink every day for about 2 months. If it's safe and doesn't cause any problems. If it makes a difference in the size and function of the kidneys.

Who can join?

People between 16 to 70 years old who have ADPKD. Those with a certain amount of kidney size and function. People who haven't been on specific diets or lost a lot of weight recently. Women who are not breastfeeding and are using birth control. People with a body weight that is not too low or too high.

Who cannot join?

People who've been on a high-fat diet or skipped meals for a while recently. Those with other health conditions like diabetes or certain metabolic issues. Anyone who has a problem with getting an MRI scan. If participants are in another medical study right now.

The study will happen in two Belgian hospitals and is supported by the UZ Brussel's nephrology department. The investigators hope to include 20 people and start in November 2023.


Eligibility Criteria:
Inclusion Criteria:

* - ADPKD patients (diagnosis based on genetics or imaging) ≥ 16 and ≤ 70 years.
* Total Kidney Volume ≥ 600 mL.
* eGFR (CKD-EPI) ≥ 30 ml/min/1.73m2.
* Normal blood glucose, HbA1C and ketones.
* Women of childbearing potential who are non-lactating and using an effective form of birth control.
* Stable disease-modifying treatment for the last 2 months.
* Well controlled hypertension (stable antihypertensive medications for at least 2 months).
* BMI \> 18 \< 30.
* Written informed consent.

Exclusion Criteria:

* Exposure to a ketogenic diet or intermittent fasting for more than 2 weeks within 6 months before inclusion.

  * Significant weight-loss (\> 10%) within 6 months before inclusion.
  * Diabetes mellitus.
  * Conditions prohibiting the use of a ketogenic diet (liver damage, pancreatic failure, pyruvate-carboxylase deficiency, defects in fatty acid oxidation/gluconeogenesis/ketolysis/neogenesis, hyperinsulinism), based on patient history.
  * Diagnosis with any disorder of fatty acid metabolism based on patient history.
  * Eating disorder.
  * Alcohol abuse.
  * Contraindication for MRI.
  * Participation in other interventional trial.
TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery

Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery.

The two anesthetic techniques used in bariatric surgery are gas anesthesia (Remifentanil TCI and Desfluran) and Total Intra Venous Anesthesia (TIVA) with propofol. There are studies which have shown a reduction in postoperative nausea and vomiting following TIVA, and there are publications showing no statistically significant difference.

The aim of this study was to investigate the best anaesthetic approach for obese subjects, evaluating awakening time, postoperative nausea and pain.

Our hypothesis was based on the fact that Propofol is a lipid-soluble anesthetic and therefore might have a prolonged effect in obese patients, leading to a longer awakening time along with postoperative nausea and vomiting. This hypothesis is also described earlier by obese patients have more depots (bulk fat) and also more fat surface making anaesthetics storage more easier, and also that the anesthetic will return into the circulation when the administration is stopped \[18\].


Eligibility Criteria:
Inclusion Criteria:

* BMI ≥35 kg/m2 with at least one comorbid condition or BMI ≥40 kg/m2.

Exclusion Criteria:

* drug abuse
* severe mental illness
* age\<18
* serious medical condition; cancer, end-stage lung disease (ASA\>3) or allergies to any drugs used in the study
The Effect of Listening to Music on Chronic Low Back Pain

The effects of passive music listening on pain, anxiety and quality of life in patients with chronic low back pain in addition to physical therapy will be examined.

The aim of the study was to investigate the effects of passive music listening in addition to physical therapy on pain, anxiety and quality of life in patients with chronic low back pain.There is no study in the literature examining the relationship between music listening and physical therapy in chronic back pain. Since our study will be the first to investigate the subject, we foresee that it is scientifically important and will shed light on future studies. In addition, national or international publications are planned after the study is completed.

Eligibility Criteria:
Inclusion Criteria:

patients with LBP for more than 3 months with pain severity of 5 or greater according to the visual analogue scale (VAS)

Exclusion Criteria:

individuals who regularly take painkillers or anti-depressant and cortisone; pregnant individuals; and individuals having severe chronic illness and spine surgery were excluded from the study
Impact of Tensor Fascia Lata Stretch on Vastus Medialis Obliqus Activity

Patellofemoral pain syndrome (PFPS) is one of the most typical causes of anterior knee pain in adolescents and young adults under the age of 50.It is believed that imbalanced action between quadriceps components, is the most contributing cause of PFPS.Investigating exercises that increase VMO muscle activation and enhance the ratio between VMO and VL have been a standardized target in literature.

Participants will have the assessed limb ready by shaving the hair on thigh and using alcohol swabs to clean the area from any residues.

For the VMO, a surface EMG electrode will be placed 4 cm superior and 4 cm medial to the supromedial boarder of patella at approximately 55 degrees to the long axis of the femur. As for the VL, the electrode will be placed 10 cm superior and 6-8 cm lateral to the superior lateral boarder of the patella and orientated 15 degrees to the vertical. All electrodes are self-adhesive (Figure 8) and will be connected to EMG sensors that will be attached and secured by double-sided tape.Each participant will perform three consecutive squats with 5 seconds interval break between each repetition. The squat depth will be kept at 50 degrees knee flexion. Mean muscle activity from three squat repetitions of VMO and VL is recorded and VMO:VL ratio is calculated. Afterward, each participant will perform the TFL stretch and repeat the three squats again.

Eligibility Criteria:
Inclusion Criteria:

1. Both genders.
2. Body mass index (BMI) ranges from 18.5 to 29.9.
3. Age ranges between 18 and 30 years old.
4. Experience nontraumatic anterior knee pain.
5. Pain with any two activities, including running, jumping, squatting, kneeling, stair ascent/descent or prolonged sitting.
6. Having at least one positive PFPS clinical tests including, patellofemoral compression, patellofemoral gliding or resistive quadriceps setting

Exclusion Criteria:

1. Coexisting pathology around the knee, including patellar subluxation or dislocation.
2. Previous knee surgery.
3. Suspicion of patellar tendinopathy, with strong consideration of pain localised to the patellar tendon.
4. Patients didn't receive physiotherapy treatment or use of non-steroidal anti-inflammatory drugs for knee pain in the previous 3 months.
5. Any neurological or rheumatic disorders
6. Pain intensity more than 5 (based on visual analogue scale)
7. Hip and ankle pathology.
8. BMI more than 30%.
9. Pregnancy.
Effect of Motivational Interviewing on Sleep Hygiene, Sleep Quality and Quality of Life

* Sleep hygiene education and motivational interviewing have an effect on increasing sleep hygiene in individuals undergoing hemodialysis treatment
* Sleep hygiene education and motivational interviewing have an effect on increasing sleep quality in individuals undergoing hemodialysis treatment
* Sleep hygiene education and motivational interviewing have an effect on increasing quality of life in individuals undergoing hemodialysis treatment

After the pre-tests are applied to the patients in the intervention group, face-to-face sleep hygiene training will be given, and then 4 sessions of motivational interviews will be held within 6 weeks.

The sessions will be conducted online with each patient individually. The post-test will be applied 10 weeks after the pre-test.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing hemodialysis at Akdeniz University Hospital
* Having been on a routine hemodialysis program for at least 3 months,
* Having a score of ≥ 26 according to the Sleep Hygiene Index
* Having dialysis adequacy (KT/V and URR values within normal range)
* Being an individual aged 18 and over
* Not having any written or verbal communication barriers
* Being able to use technological devices such as computers, tablets, mobile phones to conduct online motivational interviews
* Being willing to participate in online motivational interviews

Exclusion Criteria:

* Having a health problem that affects sleep patterns (sleep apnea, surgical operation (temporary hemodialysis catheter insertion and other surgical procedures, depression, anxiety disorder, etc.)
* Having previously attended any motivational interview session for sleep hygiene
Daily Habits & Consumer Preferences Study

The study will use a between-subjects design in a sample of individuals with BMI greater than or equal to 28 from the Los Angeles community (N=330). Participants will be randomly assigned to a weight stigma vs. control manipulation. Changes to the following health behaviors will be subsequently measured in their everyday lives: 3-day diet as captured by ecological momentary assessment (EMA) food diaries, objectively measured eating of obesogenic foods, objectively measured physical activity captured by 24-hour actigraphy, and sleep, captured objectively by overnight actigraphy and subjectively self-reported sleep measures. The investigators hypothesize that weight stigma causes decrements in health behaviors (e.g., sleep, eating, and physical activity) in everyday life.


Eligibility Criteria:
Inclusion Criteria:

1. Age 18+
2. English-speaking
3. BMI greater than or equal to 28

Exclusion Criteria:

1. Major mental disorder including eating disorder, mood disorder, schizophrenia, PTSD
2. Recent (\<1 year) diagnosis of major physical conditions that limit physical movement
3. Recent (\<1 year) diagnosis of sleep disorder
4. Allergy to any of the foods in the food buffet
Clinical Research on a Novel Deep-learning Based System in Pancreatic Endoscopic Ultrasound Scanning

The goal of this clinical trial is to develop and verify the auxiliary role of the artificial intelligence system in pancreatic ultrasound endoscopic scanning.The main questions it aims to answer are as follows: 1.The comparison of the image recognition accuracy between the artificial intelligence system and the ultrasound endoscopist; 2. Whether the artificial intelligence system can improve the efficiency of the pancreatic scanning for the ultrasound endoscopist. Participants will undergo pancreatic EUS with or without the assistance of the artificial intelligence system.

In this study, pancreatic endoscopic ultrasound scanning videos and images will be collected. First of all, an artificial intelligence system based on deep learning for the navigation and quality control of pancreatic endoscopic ultrasonography will be established. Secondly, the artificial intelligence system will be used to identify the site and anatomical structure of the pancreatic ultrasound endoscopy, and the results of the artificial intelligence system's station recognition will be compared with the results of the endoscopist's station recognition. Finally, the completeness of standard sites and scanning time of endoscopic-assisted and non-assisted AI systems were compared.

Eligibility Criteria:
Inclusion Criteria:

* 1. Age ≥18 years old, \<80 years old 2.Patients who need endoscopic ultrasonography of pancreas; 3. Agree to participate in this study and sign the informed consent form.

Exclusion Criteria:

* Subjects who meet any of the following criteria cannot be selected for this trial:

First. The patient's physical condition does not meet the requirements of conventional endoscopic ultrasonography:

1. Poor physical condition, including hemoglobin ≤8.0g/dl, severe cardiopulmonary insufficiency, etc.
2. Anesthesia assessment failed
3. Pregnancy or breastfeeding
4. In the acute stage of chemical and corrosive injury, it is very easy to cause perforation
5. Recent acute coronary syndrome or clinically unstable ischemic heart attack
6. Heart disease patients with right-to-left shunt, patients with severe pulmonary hypertension (pulmonary artery pressure\> 90mmHg),patients with uncontrolled systemic hypertension and patients with adult respiratory distress syndrome.

Second. Disagree to participate in this study.

Third. There are other problems that do not meet the requirements of this research or that affect the results of the research:

1. Pancreatic disease has undergone surgery or radiotherapy and chemotherapy beforehand;
2. Mental illness, drug addiction, inability to express themselves or other diseases that may affect follow-up.
Sentinel Lymph Node Total Tumoral Load as a Predictor of Non Sentinel Node Involvement in Early Breast Cancer

This is a retrospective, multicentric cohort study of patient cases with cT1-3, N0 early breast cancer, who previously had intraoperative sentinel lymph node (SLN) evaluation by one-step nucleic acid amplification (OSNA) assay with a complete axillary dissection.

The aim of the present study is to assess the intraoperative positive SLN total tumor load (TTL) obtained from the OSNA assay and to determine whether this TTL predicts non-SLN metastasis in patients with clinically node-negative early-stage breast cancer.


Eligibility Criteria:
Inclusion Criteria:

* Pathologically confirmed invasive breast carcinoma
* Stage T1-3,N0 evaluated by physical exam or imaging according to AJCC v.7 and best clinical local practices
* Intraoperative evaluation of sentinel lymph node (SLN) by OSNA
* Complete dissection of axillary lymph nodes after the evaluation of the SLNs by OSNA
* Pathology report of the tumor and dissected lymph nodes that includes the following information:

  * primary tumor size (mm), tumor grade (Scarff-Bloom Richardson), estrogen receptor status
  * progesterone receptor status
  * HER2 status (ASCO/CAP guidelines)
  * Ki67 index
  * presence/absence of lymphovascular invasion
  * total number of sentinel and non-sentinel lymph nodes dissected during surgery
  * total number of positive and negative sentinel and non-sentinel lymph nodes, \*size of the metastasis in both sentinel and non-sentinel lymph nodes
  * total tumoral load in each sentinel lymph node, expressed as number of CK19 mRNA copies per microliter.

Exclusion Criteria:

* Patients who underwent neoadjuvant chemotherapy
* CK19-negative breast tumor
* ALND with \<10 lymph nodes
* In situ carcinoma only
* Metastatic breast cancer at time of diagnosis
Effects of Exercises on Total Body Health in Children With Acute Lymphoblastic Leukemia

In recent years, the survival of patients has increased with the success of leukemia treatment in children. However, according to the treatment modalities applied, complications such as changes in body composition such as obesity, osteoporosis and impaired bone health such as increased fragility are more frequent after treatment in patients.In this study, virtual reality exercise practices in remission of acute lymphoblastic leukemia cases will prevent negative effects on bone health and body composition and increase the quality of life of patients.

Treatment and intervention options are being tried to avoid such complications that affect the quality of life of patients and there is still no standard treatment to convert bone health to healthy bone structure before the disease. There is a positive effect of improving the bone health of the activity and exercise programs. In this study, it was planned to demonstrate the positive effects of these changes on bone health through changes of adipokines and myokins released from fat and muscle tissue by virtual reality exercise method. Thus, the quality of life can be increased and cancer complications can be reduced in cancer cases.

Eligibility Criteria:
Inclusion Criteria:

* Treatment for acute lymphoblastic leukemia
* At remitted term
* Being between 3 and 18 years
* Healthy cases of age and gender control group cases

Exclusion Criteria:

* Smaller than 3 years old and older than 18 years old
* Having a chronic illness
* Any drug use
* Any developmental anomaly