cyrilzakka/clinical-trials huggingface dataset:
Systemic Steroids for Peripheral Nerve Blocks

This study will investigate the ability of systemic dexamethasone to prolong the sensory block duration for lumbar plexus nerve blockade.

The purpose of this randomized, double-blinded, placebo-controlled trial is to examine the equivalency of two different doses of dexamethasone when given intravenously as an adjuvant medication for postoperative pain management. Specifically, this study will investigate the prolongation of time to recovery of sensation following a lumbar plexus block in patients undergoing total hip arthroplasties. The investigators hypothesize that dexamethasone will prolong the sensory block time when compared to placebo and that similar results will be obtained in the 4 mg arm when compared to the 8 mg arm. The primary end point will be time to sensory recovery in the femoral nerve cutaneous distribution (part of the lumbar plexus) as determined by pin-prick sensation assessment. Secondary endpoints will include, but are not be limited to: time to first opioid administration, total opioid consumption over 30 hours, and rest and incident verbal numerical pain scores at 6,12,18,24 and 30 hours post block placement.

Eligibility Criteria:
Inclusion Criteria: Primary elective total hip arthroplasty surgery

* must be a candidate for placement of a lumbar plexus block under anatomic landmark technique using electrical stimulation
* must give written informed consent for anesthesia
* must also be reliable and able to give accurate verbal pain scores postoperatively

Exclusion Criteria:

* contraindications to regional anesthesia including, allergy to amide local anesthetics, presence of peripheral neurologic dysfunction, pre-existing coagulopathy or infection in the area of interest will be excluded.
* insulin and non-insulin dependent diabetes mellitus
* preoperative use of systemic corticosteroids within 30 days of surgery
* chronic opioid use (defined as daily opioid dose of greater than 40 mg of oxycodone equivalents or any long-acting opioid)
* pregnancy
* failure to effectively place the lumbar plexus block.
* known prior adverse reaction to dexamethasone (for example: psychosis) or an allergy to dexamethasone
Antagonist Activation Measurement at the Ankle Using High-density and Bipolar Surface EMG in Chronic Hemiparesis

In chronic hemiparesis, abnormal antagonist muscle activation in the paretic lower limb contributes to impair ambulation capacities. A biased estimate of antagonist muscle activation when using surface bipolar EMG compared with high-density (HD) EMG has been previously reported in healthy subjects. The present study compares muscles cocontraction at the paretic ankle estimated with a pair of and multi-channel surface EMG.

In chronic hemiparesis, gait velocity deficit is associated with a disturbed voluntary movement caused especially by inappropriate antagonist muscle activation. The present study investigates muscles cocontraction at the paretic ankle estimated with a pair of and multi-channel surface EMG (HD-EMG) in patients after stroke. HD-EMGs were collected from gastrocnemius medialis (GM), tibialis anterior (TA) and soleus (SO) during isometric contractions. From these EMGs the study asked whether bipolar and HD-EMGs provided comparable estimates of antagonist activation. Two active contraction levels (submaximal vs. maximal) and knee positions (flexed vs. extended) were assessed for each muscle. Notwithstanding the evidence of localized antagonist activation in the GM muscle of healthy subjects, hypothesizing equally localized antagonist activation in the paretic limb may not follow from the current literature. In virtue of evidence supporting the enlargement of motor unit territories in paretic and hyperactive muscles, it may be that stroke survivors have lost their ability to regionally and appropriately activate their muscle. In this case, bipolar and HD-EMG would be expected to provide comparable antagonist activation coefficients.

Eligibility Criteria:
Inclusion Criteria:

* hemiparesis due to a non-evolutive central nervous system lesion
* time since lesion ≥ 6 months
* ability to walk 10 meters barefoot without any assistance
* cognitive abilities to understand the verbal instructions for the test according to the investigator's judgment
* absence of botulinum toxin injections within the last 3 months prior to enrolment

Exclusion Criteria:

* botulinum toxin injections within the last 3 months prior to enrolment
Atropine Versus Glycopyrrolate in Preventing Spinal Anesthesia Induced Hypotension in Lower Limb Surgeries

A study to compare between intravenous atropine and glycopyrrolate in preventing spinal anesthesia induced hypotension in patients undergoing major lower limb orthopedic surgeries. Hypotension is the most common complication in spinal anesthesia that can be life threatening. If this can be prevented patients comfort can be increased and satisfaction as well.


Eligibility Criteria:
Inclusion Criteria:

* ASA PS I and II,
* age 16 to 65,
* undergoing lower limb major orthopedic surgery,
* willing to participate

Exclusion Criteria:

* Contra indication to spinal anesthesia,
* patient refusal,
* ASA PS \>III,
* cardiac diseases,
* hypertension \>160/ 100,
* arrhythmias,
* Acute coronary syndrome,
* patients taking beta-blockers,
* hepatic and pulmonary diseases
Assessment of Serological Techniques for Screening Patients Regarding COVID-19-COVID-SER

Covid-SER is a prospective multi-center study for the evaluation of diagnostic performance of available serological tests


Eligibility Criteria:
Inclusion Criteria:

* Seropositive caregivers screened for anti-SARS CoV2 antibodies during their consultation at the occupational medicine of HCL.
* Age: ≥ 18 years old
* Persons having given their written consent and accepting a follow-up every 6 months for 24 months, followed by a final visit at 36 months.
* Persons affiliated to a social security scheme or beneficiary of such a scheme.

Exclusion Criteria:

* Pregnant or lactating woman
Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation

Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.

Prospective observational clinical multicentric study on ICU ventilated patients requiring chest ultrasound analysis during weaning from mechanical ventilation with 48 hours of follow-up. Studying variations of cardiac markers

Eligibility Criteria:
Inclusion Criteria:

- Adult patients ventilated more than 48 h

* Stable respiratory and hemodynamic conditions for SBT
* Consent of patients
* Arterial line

Exclusion Criteria:

* Laryngeal dyspnea
* Tracheostomy
* Arythmya
* No echogenicity
* Paraplegia \>T8
Family ASL: Longitudinal Study of Deaf Children and Hearing Parents Who Receive Services to Support the Learning of ASL

This study examines the development of American Sign Language by deaf and hard of hearing (DHH) children and their parents.

After being informed about the study and potential risks, adult participants who give written informed consent and children whose parents who give written permission will be enrolled in the study. They will participate in preliminary language tasks to assess baseline performance on American Sign Language (ASL) measures. Subsequently they will have weekly sessions with an ASL Specialist to support their development of ASL, following a 6-week on/6-week off ABABABAB sequence.

Eligibility Criteria:
Inclusion Criteria:

Children:

* Children ages 2;00 - 2;11 at the start of the longitudinal project
* Child is Deaf/ Hard-of-Hearing
* Participating in a program utilizing a bimodal bilingual philosophy

Adults:

- One adult caregiver for each child

Exclusion Criteria:

* Children with previously-diagnosed conditions other than deafness known to affect language and cognitive development
* Families without access to internet (at home or other locations)
Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline

The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance and further characterization of individuals with subjective cognitive decline.

Memory abilities are known to decline during aging, a process that is accelerated in pathological conditions like mild cognitive impairment (MCI) and Alzheimer's disease (AD), all of which are a growing public-health concern with devastating social and economical effects. Polyamines supplementation and corresponding up-regulation of autophagy (i.e., cellular protein degradation pathways) may be a key target of intervention against age-related memory decline. The study will investigate whether a polyamine-enriched dietary supplementation (through capsule intake) could provide positive effects on cognitive function and biomarkers of elderly individuals (60-90 years old) with subjective cognitive decline (SCD).

Eligibility Criteria:
Inclusion Criteria:

* Cognitive healthy individuals with subjective memory decline and self-reported concerns
* 60-90 years old
* No manifest dementia (DSM-IV criteria)
* No limitations in activities of daily living
* Capacity for consent

Exclusion Criteria:

* Gluten, histamine or wheat seedling intolerance
* Severe neurological, internal or psychological diseases
* Advanced heart or respiratory diseases, severe arteriosclerosis, untreated thyroid disease or diabetes
* Malignant tumors, current or past history
* Brain tumors, stroke
* Disorders that impair attention
* Dementia
* Coagulation disorder, Marcumar
* Drug abuse or alcohol dependency
* Current polyamine substitution
Evaluation of the Nicotine Lozenge in Relief of Provoked Acute Craving

This study is designed to evaluate the ability of a nicotine lozenge to relieve craving for a cigarette compared to a matched placebo (a placebo is like sugar pill and contains no active).


Eligibility Criteria:
Inclusion Criteria:

* Generally healthy smokers who smoke more than 5 cigarettes per day
* Body mass index (BMI) within the range 19-35 kilogram (kg)/meter (m)\^2
* Females of childbearing potential who are, in the opinion of the investigator, practicing a reliable method of contraception.

Exclusion Criteria:

* Women who are pregnant or who have a positive urine pregnancy test.
* Participants with known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.
* Clinical Study/Experimental Medication: Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit.
* Prior Concomitant Medication: Treatment with enzyme altering agents (e.g. carbamazepine, phenytoin, cimetidine, sodium valporate) within 30 days of the craving provocation visit; Use of any prescription psychoactive medication (such as but not limited to antidepressants, antipsychotics, anxiolytics) within 14 days of the craving provocation visit; Participant has used an over-the-counter (OTC) medication such as antihistamines, sedating agents, or any compound that would have a sedating effect within 24 hours of the craving provocation visit; Current use of any nicotine replacement therapy.
* Substance abuse: Recent history or current history (within the last 1 year) of alcohol or other substance abuse.
Pilot Study to Evaluate Optical Frequency Domain Imaging for Diagnosis of Central Airway Disease

This study will evaluate a new imaging technology, termed optical frequency domain imaging (OFDI) for detecting and diagnosing pulmonary malignancy in the central airways.

The prevalence and high mortality rate associated with lung squamous cell carcinoma and the lack of any widely accepted screening and surveillance tools, highlights the need for new imaging paradigms that will ultimately lead to a reduction in patient mortality.

Bronchial carcinoma-in-situ will progress to invasive cancer in over 40% of individuals, and although the progression occurs over a long period of time, the majority of carcinomas are detected in the later stages of disease development, offering patients only a slim chance of cure. Although significant effort in the development of screening paradigms for the detection of lung cancer in the central airways have been made, to date there is still no widely accepted and validated approach. Optical frequency domain imaging (OFDI) is a recent derivative of optical coherence tomography (OCT). OFDI can be used to conduct volumetric microscopy of the airways at a resolution comparable with architectural histopathology. The long term goal of this study is to use OFDI to screen the airways with the hope of detecting squamous cell carcinoma at an early more curable stage.

Standard of care bronchoscopy preparation and procedures will be followed including moderate sedation, pulse oximetry and blood pressure monitoring as per department protocol. A combination of currently approved bronchoscopy techniques including standard white light bronchoscopy, autofluorescence bronchoscopy, and narrow band imaging will be used to assess the airways. Bronchial regions of interest (ROI) suspected to be premalignant or malignant, will be imaged using the OFDI system and catheter prior to biopsy acquisition. It is anticipated that a minimum of 3 OFDI-biopsy correlated pairs from each study participant will be obtained. An additional OFDI and biopsy will be obtained from a normal ROI. It is expected that the experimental procedure will add less than 10 minutes to the total length of the bronchoscopy procedure, but a stopping rule will be instituted to ensure that the experimental procedure does not exceed 20 minutes.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing bronchoscopy for known or suspected pulmonary malignancy in the central airways
* Patients must be over the age of 18
* Patient must be able to give informed consent
* Women with child bearing potential must have a negative pregnancy test the day before or the day of the procedure.

Exclusion Criteria:

- Patient does not meet the requirements to undergo clinical bronchoscopy, as determined by the treating physician.
Silver Diamine Fluoride Modified Restoration In Treating Hypomineralized First Permanent Molar.

A randomized clinical trial to compare silver modified glass ionomer restorations to non silver glass ionomer restorations in hypo-mineralized first permanent molars in children and to measure the amount of wear of restoration in both groups along with detecting changes in hypersensitivity in hypomineralized molars in both groups after one year follow up.


Eligibility Criteria:
Inclusion Criteria:

* Bilateral first permanent molars affected with molar incisor hypomineralization and with the same ICDAS II score.
* Both chosen molars should be of the same degree of MIH severity.

Exclusion Criteria:

* signs and symptoms of irreversible pulpitis or pulp necrosis.
Clinical Observational Registry of Patients With Left Bundle Branch Block

The electromechanical dyssynchrony induced by the presence of LBBB is in some patients, but not all, the cause of progressive left ventricular systolic dysfunction and heart failure.

Aims

1. To investigate the clinical, ECG, imaging-derived features in a large cohort of patients affected by LBBB on ECG.
2. To identify predictors of LBBB-induced LV systolic dysfunction and predictors of outcome in this population.
3. To derive data which may have an impact on therapeutic management.


Eligibility Criteria:
Inclusion Criteria:

* LBBB on ECG

Exclusion Criteria:

* Previous extensive anterior myocardial infarction
* Previous cardiac surgery or transcatheter aortic valve implantation (TAVI)
* Congenital structural heart disease
* Patients implanted with permanent right ventricular stimulation devices and permanent pacing
* Denial to consent
Intravitreal Anti-vascular Endothelial Growth Factor Administration and Its Influence on Vitreomacular Interface- and Retinal Morphology in Eyes With Neovascular Age-related Macular Degeneration

Purpose:

To assess the influence of intravitreal anti-vascular endothelial growth factor (anti-VEGF) administration on vitreomacular interface- and retinal morphology in eyes with neovascular age-related macular degeneration (AMD) and to identify morphological markers potentially influencing disease prognosis.

Methods:

43 patients (51 eyes) with treatment naïve neovascular AMD subsequently treated with Bevacizumab 1.25mg (in 0.05ml of solution) were monitored until month 12 of follow-up. Following a loading dose of 3 monthly intravitreal anti-VEGF injections, patients were treated as-needed \[pro re nata (PRN)\]. Functional and morphological changes were assessed using Spectral Domain Optical Coherence Tomography (SD-OCT).

This retrospective study included 43 treatment-naive patients (51 eyes) with neovascular AMD over the course of 12 months. Patients were treated with a loading dose of 3 initial monthly anti-VEGF injections (Bevacizumab 1.25mg in 0.05ml of solution-Avastin®) and were followed monthly until year 1. Re-treatment was performed if needed (pro re nata-PRN) as previously reported.

Eligibility Criteria:
Inclusion Criteria:

- diagnosis of treatment-naive neovascular AMD

Exclusion Criteria:

* any treatment with other anti-VEGF agents than Bevacizumab in the follow-up period
* any other diseases leading to macular edema
* prior vitrectomy
* uveitis
* retinal or corneal laser surgery
* high myopia (\>6dpt)
* preceding eye trauma
Immediate Effects of Eurythmy Therapy on Psychophysiological Parameters

The purpose of this study is to investigate different effects of Eurythmy Therapy on psychological and physiological parameters of circulation and thermoregulation


Eligibility Criteria:
Inclusion Criteria:

* Healthy adults 18-55 Years old, signed informed consent available

Exclusion Criteria:

* Any known diseases of the cardiovascular system, allergic reactions to electrode patches in the past, coffee, alcohol or smoking less than 3 hours prior to the study, insufficient knowledge of the German language
Ultrasound Assessment of Gastric Volume in High-Risk Pregnant Women At Term

The risk of pulmonary aspiration of gastric contents remains a significant risk during anesthesia, especially in pregnant women, as they may often require surgery without having observed appropriate fasting. A bedside ultrasound assessment of the status of the gastric content would be of great value for the clinician.

This prospective observational study aimed to (1) qualitatively and quantitatively describe the sonographic appearance of the gastric antrum in fasted high-risk pregnant women during the third trimester and (2) evaluate the relationship between demographic and clinical variables and the gastric antral cross-sectional area (CSA).

The aim of this prospective study is to provide a qualitative and quantitative description of the sonographic appearance of the gastric antrum in fasted high-risk pregnant women in the 3rd trimester.

The investigators expect that the information obtained from the systematic ultrasonographic qualitative/quantitative assessment of the gastric content may help anesthesiologist to better assess aspiration risk and guide anesthetic and airway management, particularly in pregnant women scheduled for elective Cesarean delivery after standard preoperative fasting guidelines.

Eligibility Criteria:
Inclusion Criteria:

1. Non-labouring pregnant women at 3rd trimester (≥ 28 weeks)
2. 18 years or older.
3. ASA physical status I-III
4. Hospitilized in High Risk Pregnancy Department
5. Ability to understand the rationale of the study assessments and provide signed informed consent.
6. Written informed consent

Exclusion Criteria:

1. Patients with American Society of Anesthesiology (ASA) physical status class IV.
2. Patient age \< 18 years
3. Pregnant patients with upper gastrointestinal (GI) disease and pathology.
4. History of upper GI tract surgical procedures.
5. History of medications that affect gastrointestinal motility.
6. Inability to understand the rationale of the study assessments and provide signed informed consent.
Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia

This research study is being done to develop a brain controlled medical device, called a brain-machine interface or BMI, that will provide people with a spinal cord injury some ability to control an external device such as a computer cursor or robotic limb by using their thoughts.

Developing a brain-machine interface (BMI) is very difficult and currently only limited technology exists in this area of neuroscience. The device in this study involves implanting very fine recording electrodes into areas of the brain that are known to create arm movement plans and provide hand grasping information. These movement and grasp plans would then normally be sent to other regions of the brain to execute the actual movements. By tying into those pathways and sending the movement plan signals to a computer instead, the investigators can translate the movement plans into actual movements by a computer cursor or robotic limb.

The device being used in this study is called the NeuroPort Array and is surgically implanted in the brain. This device and the implantation procedure are experimental which means that it has not been approved by the Food and Drug Administration (FDA). One NeuroPort Array consists of a small grid of electrodes that will be implanted in brain tissue with a small cable that runs from the electrode grid to a small hourglass-shaped pedestal. This pedestal is designed to be attached to the skull and protrude though the scalp to allow for connection with the computer equipment.

The investigators hope to learn how safe and effective the NeuroPort Array is in controlling computer generated images and real world objects, such as a robotic arm, using imagined movements of the arms and hands. To accomplish this goal, two NeuroPort Arrays will be used.


Eligibility Criteria:
Inclusion Criteria:

* High cervical spinal lesion
* Able to provide informed consent
* Able to understand and comply with instructions in English
* Able to communicate via speech
* Surgical clearance
* Life expectancy greater than 12 months
* Live within 60 miles of study location and willing to travel up to 5 days per week
* A regular caregiver to monitor the surgical site
* Psychosocial support system

Exclusion Criteria:

* Presence of memory problems
* intellectual impairment
* Psychotic illness or chronic psychiatric disorder, including major depression
* Poor visual acuity
* Pregnancy
* Active infection or unexplained fever
* scalp lesions or skin breakdown
* HIV or AIDS infection
* Active cancer or chemotherapy
* Diabetes
* Autonomic dysreflexia
* History of seizure
* Implanted hydrocephalus shunt
* Previous neurosurgical history affecting parietal lobe function
* Medical conditions contraindicating surgery and chronic implantation of a medical device
* Prior cranioplasty
* Unable to undergo MRI or anticipated need for MRI during study
* Nursing an infant or unwilling to bottle-feed infant
* Chronic oral or intravenous use of steroids or immunosuppressive therapy
* Suicidal ideation
* Drug or alcohol dependence
* Planning to become pregnant, or unwilling to use adequate birth control