Normal Quantitative EEG (qEEG) Dataset

In this study, the investigators will collect EEG data in normal, healthy volunteers without a history of prior brain injury. This data will be analyzed by computer (quantitative, or qEEG) and stored in a normative database so that, in the future, the investigators can better understand and characterize the brain damage that can result from carbon monoxide (CO) poisoning and other types of brain injury.

This is a pilot, prospective, non-comparative, non-invasive, minimal risk research study to obtain qEEG data on normal, healthy individuals to include in a normal control database for use in comparison with patients with CO poisoning and other types of brain injury. The use of anti-depressant medication use is relatively common in the general adult population. There is varying opinion whether anti-depressant medication alters an otherwise normal clinical EEG. We have included healthy individuals taking anti-depressant medication to determine if those medications influence the EEG. The EEG data will be collected, analyzed, and stored for use in future research studies and for clinical care. Evaluating patients with qEEG methodology may assist in diagnosis and treatment.

Eligibility Criteria:
Inclusion Criteria:

* Men and women, from 18 to 55 years old at the time of study enrollment. Women who are greater than 6 weeks post-partum, who are breastfeeding are allowed to participate if they are able to finish the electroencephalography (EEG) without interruption.
* Able to speak and read English as their primary language.
* Agrees to, and appears able to, participate in all outcome assessments.
* Demonstrates the ability to offer informed consent and signs the study informed consent document.

Exclusion Criteria:

* Vulnerable populations including, prisoners, pregnant women, and minors.
* Women who are less than 6 weeks post-partum.
* Unwilling or unable to participate in planned study visits.
* Any past history of brain injury due to trauma, surgery, hypoxia, infection, inflammation, toxicity (e. g., carbon monoxide poisoning), or cerebrovascular etiology.
* Individuals with a diagnosis of, or a persistent history of, or symptoms of a neurological disorder (e.g., tinnitus, vertigo, chronic fatigue, numbness, tingling, chronic migraine, fibromyalgia, multiple sclerosis).
* Currently undergoing therapy for affective disorders, behavioral disorders, or psychological disorders.
* Diagnosis of post-traumatic stress disorder or sub-clinical post-traumatic stress symptoms.
* Diagnosis of diabetes mellitus, type 1 and type 2.
* Current complaints of brain injury symptoms such as cognitive or affective problems.
* Known neuroimaging abnormalities.
* Participants taking daily prescription drugs or oral over the counter medications beyond vitamins that could impact a normal outcome determined by the Principal Investigator (e.g., beta blockers).
* Participants who are ≥45 may be taking statins or angiotensin converting enzyme (ACE) inhibitors.
* Participants between the ages of 18-55 may be taking antidepressants indicated for depression or post-partum depression.
* Oral or injectable contraceptives are permitted
* Known atrial septal defect, including but not limited to patent foramen ovale.
* History of bypass surgery.
* History of hydrocephalus/microcephaly/macrocephaly.
* History of developmental delay or learning disorder as a child.
* Previous or current use of any illicit drug, at any age.
* Current positive urine drug test for any illicit substance.
* History, by self-report in the last year, of alcohol abuse.
* Current or previous tobacco use, with the exception of minimal use during adolescence.
* Use of any assistive hearing device, or unable to verbally communicate due to hearing loss.
* History, by self-report, of receiving chemotherapy drugs or therapeutic ionizing radiation to the head.
* Foreign material in the head.
* Active malignancy or prior malignancy (except basal cell carcinoma) within the last 5 years.
* Unable to abstain from caffeine products for at least a 2 hour interval.