cyrilzakka/clinical-trials huggingface dataset:
A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients

This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.

This observation study is aimed at investigating the gut microbiota alteration in gastrointestinal lymphoma (GIL) patients by performing metagenomic shotgun sequencing on GIL patients' fecal specimen. Before immuno-chemotherapy, the feces specimen of GIL would be collected and stored for further laboratory examination. This study would NOT alter the subsequential treatment of the patients.

Eligibility Criteria:
Inclusion Criteria:

* Gastrointestinal lymphoma with a clarified pathological diagnosis
* De novo gastrointestinal lymphoma patients who haven't received chemotherapy
* BMI in normal range

Exclusion Criteria:

* Antibiotics or probiotics application within a month
* Overweight (BMI≥25) or malnourished (BMI\<18.5) patients
* Patients who have been accepted gastrointestinal fistulation
* Gastrointestinal patients with inflammatory bowel disease (IBD), colorectal carcinoma (CRC) or any other chronic intestinal disease
* Patients infected by HIV
Treatment of Multiple Gingival Recessions

Gingival recession (GR) is frequently associated with deterioration in dental esthetics and dental hypersensitivity. Outcomes from recent systematic reviews have demonstrated that when the root is covered and the gain in the width of keratinized tissue (KT) is expected, the use of subepithelial connective tissue grafts (SCTGs) associated with coronally advanced flaps (CAF) appears to be more predictable, and may be considered the gold standard procedure. However, the SCTGs may increase patients' morbidity (e.g., pain). This occurs because of the need for a donor surgical area, which may increase the risk of surgical complications like bleeding, as well as increases post-operative discomfort and the period of the surgical procedure. Another biomaterial, a new collagen matrix (CM) has been used as a substitute for the SCTG. The use of CM was associated with a significant reduction in post-operative morbidity, less post-operative pain and discomfort in the patient, and more esthetic satisfaction.


Eligibility Criteria:
Inclusion Criteria:

* The patients will be included in the study if they fulfill the following inclusion criteria:

  1. a clinical diagnosis of multiple-recession type defects at maxillary canines and premolars with at least one GR ≥ 3mm in depth;
  2. areas of Miller's Class I or II GR;
  3. teeth without root abrasions or caries.

Exclusion Criteria: -

The exclusion criteria used will be as follows:

* patients allergic to collagen
* a history of smoking (within the previous 6 months)
* pregnancy or lactation
* a history of destructive periodontal disease or the formation of recurrent abscesses
* root caries at the site of recession
* previous surgical root coverage procedures
* systemic healing disorders (for example, acquired immunodeficiency syndrome \[AIDS\], diabetes mellitus or risk factors evaluated by a medical doctor)
* periodontal disease, or poor plaque control (full mouth plaque index \> 20%).

The exclusion criteria for teeth will be:

1. noncarious cervical lesions (erosion, abfraction etc.)
2. any type of previous cervical restoration
3. extrusion
4. giroversion
5. mobility
6. a prominent root surface.
Epidemiological Analysis on Endometrial Cancer in Guangdong Province of China

Endometrial cancer is one of the most common gynecological cancers, and the incidence increasing in the world. However, there isn't any large sample data of endometrial cancer reported in China. Thus Endometrial cancer project of Guangdong province conduct a large multicentre clinical investigation about endometrial cancer.

Endometrial cancer project of Guangdong province is mainly conducted by the Department of Gynecology of the Third Affiliated Hospital of Sun Yet-sen University, and other 62 major hospitals in Guangdong province participate in this project. In this large multicentre clinical investigation, the endometrial cancer database including more than 10,000 cases has been established. Further the investigators will demonstrate the epidemiological characteristics, etiology, risk factors, clinical treatment and prognosis of endometrial cancer.

Eligibility Criteria:
Inclusion Criteria:

* patients who was diagnosed with endometrial carcinoma from 2000 to 2010 in Guangdong province of China;
* patients with intact clinical and pathological information

Exclusion Criteria:

* not included in the inclusion criteria
Adolescent Postpartum Contraceptive Counseling Intervention

Postpartum contraceptive counseling varies widely in its provision; no standardized practice has been well-established by the literature. We intend to evaluate how directed postpartum contraceptive counseling to adolescents aged 14-19 affects key outcomes over time. Subjects will be randomized to receive either the standardized contraceptive counseling intervention or routine postpartum care. We will then assess the difference in repeat pregnancy rates between the two groups


Eligibility Criteria:
Inclusion Criteria:

* 14-19 years old
* primiparous
* immediately postpartum
* delivery of a full term live singleton infant (\>37 weeks) at HUP

Exclusion Criteria:

* not planning to reside in/near Philadelphia for the next year
Perception in Parkinson's Disease

The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to participate in this study. This is an observational study only, and not an interventional study.

For this study, the investigators propose to conduct an online study of PwPD (proposing a total of 60 participants) to examine the relations among variables that may relate to perception in PD. Those PwPD who express interest will be sent a link to an online survey (Qualtrics). The investigators will collect demographic and health information, followed by questionnaires assessing unusual perceptual experiences, mood, motivation, sleep, fatigue and quality of life. The survey should take roughly 45 minutes to an hour to complete.

Compensation: A $20 Amazon gift card will be offered to those who complete the survey all the way through with good effort.

Eligibility Criteria:
Inclusion Criteria:

* Participants must be at least 40 years old
* Have a self-reported diagnosis of idiopathic PD
* Be proficient English speakers
* Have functional vision
* Have internet access, and access to a desktop computer or laptop

Exclusion Criteria:

* Self-reported poor vision (non-functional range)
* Lack of access to internet and either a desktop computer or laptop
Magnetization Transfer Quantitation and Characterization for Clinical Scanners

This project will measure magnetization transfer (MT) parameters on normal subjects using two novel approaches. The first is the investigation of asymmetric MT effects with respect to the zero or on-resonance reference point. The technique measures the difference in MT effect between two symmetrically positioned off-resonance MT pulses in the positive and negative frequency ranges. Prior research with this technique in the kidney show a difference in the macromolecular lineshape that correlates to a specific metabolite. The second approach, utilizing a subset of the acquisitions from the first approach, will test newly developed formulation to calculate the macromolecular fraction, or fraction of proton density that accounts for MT. We foresee these measurements may significantly develop our understanding of MT and introduce diagnostic and quantitative tools to study human tissues.

This project will measure magnetization transfer (MT) parameters on normal subjects using two novel approaches. The first is the investigation of asymmetric MT effects with respect to the zero or on-resonance reference point. The technique measures the difference in MT effect between two symmetrically positioned off-resonance MT pulses in the positive and negative frequency ranges. Prior research with this technique in the kidney show a difference in the macromolecular lineshape that correlates to a specific metabolite. The second approach, utilizing a subset of the acquisitions from the first approach, will test newly developed formulation to calculate the macromolecular fraction, or fraction of proton density that accounts for MT. We foresee these measurements may significantly develop our understanding of MT and introduce diagnostic and quantitative tools to study human tissue.

Eligibility Criteria:
Normal control between the ages of 18 - 70 years of age who are capable of giving informed consent.

Subjects must not have a condition which would preclude their use for technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia, etc.).

Subjects must not have a condition which would present unnecessary risks (e.g. pregnancy, surgery of uncertain type, symptoms of pheochromocystoma or insulinoma, etc.).

Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the administration of contrast agents.

Must not have a contraindication to MR scanning such as surgery that involves metal clips or wires which might be expected to concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. Examples include: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or autodefibrillator; cochlear implant; ocular foreign body (e.g. metal shavings); insulin pump.
Intraoperative Ultrasound in Laparoscopic or Robotic Myomectomy Patients

This study evaluates whether use of intraoperative ultrasound during laparoscopic or robotic myomectomy impacts quality of life. Half of participants will undergo laparoscopic or robotic myomectomy with use of the intraoperative ultrasound and half will undergo traditional laparoscopic or robotic myomectomy.

In full acknowledgement of the correlation between complete leiomyoma exeresis and symptom relief, the investigators hypothesize that use of contact ultrasonography at the time of laparoscopic or robotic myomectomy will enable improved identification and extraction of uterine fibroids which will, in turn, lead to a greater improvement in quality of life among those women who receive intraoperative ultrasound compared to those who do not. In this blinded randomized controlled trial, the investigators will augment traditional laparoscopic and robotic myomectomy with intraoperative ultrasound in half the symptomatic patients enrolled in the study. The other half will be randomized to undergo laparoscopic or robotic myomectomy without use of intra-operative ultrasound. Both groups will complete Uterine Fibroid Symptom and Quality of Life (UFS- QOL) questionnaires before and after surgery (6 months post procedure) to determine whether use of laparoscopic contact ultrasonography has a positive impact on patients' quality of life.

Eligibility Criteria:
Inclusion Criteria:

1. Premenopausal and nonpregnant
2. Advised to undergo laparoscopic or robotic myomectomy by their provider
3. Documented imaging with transvaginal ultrasound or pelvic MRI within the past year, which accurately and within reason documents the location and number of leiomyomas present within the uterus
4. If deemed necessary by the provider, must have a pelvic MRI prior to surgery that states there are no concerning findings for malignancy
5. Must be eligible to undergo laparoscopic surgery and willing to present for clinic and imaging follow up during the 6 months following myomectomy
6. Must understand and voluntarily sign an informed consent form.

Exclusion Criteria:

1. Appearance of uterus concerning for malignancy on pelvic MRI
2. Current pregnancy
3. Any contraindication to laparoscopic or robotic surgery
4. Treatment with gonadotropin-releasing hormone (GnRH) analogs in the past 36 months
Sublingual Methadone for the Management of Cancer-related Procedure Pain in Inpatients

The purpose of this Phase II study is to determine the feasibility of the dose titration and assessment protocol in the impatient population, in the clinical setting of preventing or managing breakthrough pain, before conducting an appropriately powered phase III study. Thus the primary purpose of this study is to determine the proportion of patients who are successfully titrated to an effective dose of sublingual methadone.


Eligibility Criteria:
Inclusion Criteria:

* Pain due to cancer or its treatment; Controlled baseline pain; episodes of predictable, treatment related pain every day that are 4"/10" in severity or greater, last 10 minutes or longer, or episodes of breakthrough pain not related to cancer treatment, and are responsive to short acting oral opioids such as morphine or hydromorphone; are able to hold a volume of 1.0cc of water under tongue for a 2-minute period; are able to provide written informed consent; are able to fill out the study forms, and are inpatients

Exclusion Criteria:

* Severe underlying respiratory disease such that the investigator is wary about the risk of respiratory failure from modest doses od opioid; prior sensitivity to methadone; currently are being administered methadone; are clinically unstable or have a life expectancy of less than one month making completion of the trial unlikely; and if they do not understand English sufficiently to provide written informed consent.
Effect of a Nutritional Supplement on H&N Cancer Patients

To determine if using a nutritionally enhanced supplement will improve mucositis in head and neck cancer patients

H\&N cancer patients will be randomized to receive either a nutritionally enhanced product or standard treatment. The patients in both groups will receive nutritional counseling weekly by the RD. Anthropometric measures, available lab values, mucositis grade, and quality of life measures will be compared between groups.

Eligibility Criteria:
Inclusion Criteria:

* Head and neck cancer 1st.2nd wk Rx read \&wrte eng

Exclusion Criteria:

* receiving hospice impaired cognition
A Retrospective Comparison Between CPS and HC Techniques for Osteoporotic Fractures in the Thoracic or Lumbar Spine

Cement-augmented pedicle screws (CPS) and hybrid construct (HC) consisting of pedicle screws and additional hooks are common methods in osteoporotic fracture of the thoracic and lumbar spine. No study has compared the surgical results between CPS and HC techniques for treatment of the osteoporotic thoracic and lumbar spine fracture. The aim of the retrospective study was to compare surgical results using CPS or HC for osteoporotic fractures in the thoracic or lumbar spine. Patients who received surgical treatment with CPS or HC for osteoporotic fractures in the thoracic or lumbar spine.

Osteoporosis, the most common metabolic bone disease, leads to alteration of bone density that has been shown to compromise the strength of spinal instrumentation. With elderly populations growing, rates of spine surgery performed on osteoporotic patients have increased to treat a variety of conditions. Vertebral fracture is the most common osteoporotic fracture in the elderly, and surgical intervention is sometimes needed for patients who are diagnosed as nonunion, failure of vertebroplasty, and neurologic deficits. Therefore, spine surgeons will increasingly face the challenge of achieving rigid fixation of osteoporotic spines.

Cement-augmented pedicle screws are the most common strategy to maximize pullout strength for fixation of osteoporotic spines. Hybrid constructs, a combination of pedicle screws and hooks, offer an alternative approach to avoid implant failure and increasing construct stability when placing instrumentation in the osteoporotic spine. Biomechanical studies of either cement-augmented pedicle screws or combined pedicle screws and hooks for osteoporotic spine have demonstrated superior results compared to pedicle screws only in terms of improving implant pullout strength. However, few clinical investigation to date has focused on comparing surgical results of the cement-augmented pedicle screws (CPS) and hybrid construct (HC) techniques. The goal of the retrospective cohort study was to compare the surgical outcomes and surgery-, patient- and implant-related complications between the CPS and HC techniques for osteoporotic vertebral fractures in the thoracic or lumbar spine.

Eligibility Criteria:
Inclusion Criteria:

* Surgical treatment with CPS or HC of pedicle screws and hooks for osteoporotic fractures in the thoracic or lumbar spine
* Received a minimum of 2-year follow-up

Exclusion Criteria:

* T-scores greater than -2.5
* Cancer metastasis
* Chronic osteomyelitis
* Failure to complete the questionnaires or radiographic examinations
Fluoride-labeled Boronophenylalanine PET Imaging in Patients With Solid Tumors

Recently, new high-dose radiation therapy \[e.g., boron neutron capture therapy (BNCT)\] absorbed into the tumor tissue has been applied to treat patients with solid tumors. Here we examine and describe how to evaluate the biological activity of tumors using positron emission tomography (PET) with fluoride-labeled boronophenylalanine (F-BPA) as a tracer.

Boron Neutron Capture Therapy（BNCT） is an advanced cell-scale binary targeted radiotherapy technology that combines the advantages of targeted therapy and heavy ion therapy. BNCT provides a neutron source from a reactor or a medical accelerator. At the same time, the patient needs to be pre-injected with a boron-containing drug containing a non-radioactive boron 10 isotope. The boron drug enters the body and accumulates specifically in cancer cells. The patient receives epithermal neutron beam irradiation with high linear energy transfer (Linear EnergyTransferLET), thereby achieving the effect of killing tumor cells. Purpose，BNCT has more advantages over conventional radiotherapy, and normal tissue is better preserved than conventional radiotherapy.

PET imaging is a useful and effective technique to give absolute quantitative and biological distribution data of BPA in a non-invasive manner, and can add important characteristic parameters such as T/N ratio, SUV and Kinetic parameters. Given the complexity of BNCT, PET and PET/CT is currently the new standard for designing patient recruitment: The Methodology of L-18F-BPA PET is an important tool to design clinical trials , estimate the size of tumor and indicate the concentration ratio of BPA in surrounding normal tissues. Following this principle, researchers can accurately identify which patients can benefit from BNCT treatment through the selective accumulation of BPA in individual tumors. PET scans can provide a three-dimensional map of the boron distribution, which can be used for macroscopic dose calculations in the BNCT conventional neutron transmission code. Because most of the dose absorbed by living cells (65%) comes from the 10B(n,a)7Li response, the distribution of boron determines the variability of the main absorbed dose in the treatment plan. As a result, therapeutic schedule will be improved because the boron distribution will greatly affect the isodose line. Routine calculations provide a wider range of isodose contours, whereas PET produces contours that more closely approximate the observed clinical results of BNCT.

Eligibility Criteria:
Inclusion Criteria:

* patients with clinically diagnosed solid tumors, including but not limited to recurrent head and neck cancer, glioma, pancreatic cancer, osteosarcoma, etc.; The selected subjects need to sign the informed consent.

Exclusion Criteria:

* Pregnant women; renal failure (serum Cr\>3mg/dl); Patients with claustrophobia;
Plyometric Exercise With Obese Children

Obesity is one of the main factors that contribute to an acquired flat foot deformity which in turn impairs the balance strategies. The purpose of the current study was to compare the effect of plyometric exercises with flatfoot corrective exercise on balance, foot posture, and functional mobility in obese children with flexible flatfoot.

A sample of 47 male children participated in the current study. The participants were selected from different elementary schools in Taif, Saudi Arabia. Their age ranged from 7 to 11 years. the sample was randomly divided into 3 groups: the experimental group I, (EGI), the experimental group II, (EGII), and the control group (CG). The EGI received a plyometric exercise program. The EGII received the corrective exercises 2 sessions per week for 10 weeks. The control group did not perform any planned physical activities during the intervention period but continued in their routine physical activities. The Prokin system was used to assess the static balance, timed up and go test was used to assess functional mobility, and Navicular drop test was used to assess the degree of flatfoot deformity, prior to and after the intervention for all groups.

Eligibility Criteria:
Inclusion Criteria:

* Body mass index percentile equal to or greater than the 95th percentile
* All had no previous history of strength or balance training or involvement in competitive sports emphasizing muscular strength or balance.
* All participants had balance deficiency and mobile flat foot.

Exclusion Criteria:

* Previous injury to the lower limb required medical care.
* Confounding conditions, such as a deformity of or surgery in the lower limb.
* visual impairment, or neuromuscular disorders.
* engagement in obesity treatment programs, three months prior to the study.