cyrilzakka/clinical-trials huggingface dataset:
Effects of IASTM and Vibration Therapy in Cervical Disc Herniation

This study investigates the effects of instrument-assisted soft tissue mobilization (IASTM) and percussion massage therapy on pain, functional status, proprioception, and kinesiophobia in individuals with cervical disc herniation. A total of 66 participants diagnosed with cervical disc herniation will be randomly divided into three groups: vibration therapy, IASTM, and conventional exercise. Each group will receive conventional physiotherapy, while the intervention groups will additionally receive their respective therapies. Outcomes will be measured using the Visual Analog Scale (VAS), Neck Disability Index (NDI), Laser Pointer Joint Position Sense Test, and Tampa Scale for Kinesiophobia (TSK). The aim is to evaluate and compare the effectiveness of both therapies in reducing pain, improving functionality and proprioception, and decreasing fear of movement.

Cervical disc herniation is a common musculoskeletal condition that causes significant pain and functional limitations, often affecting individuals in their middle ages and those working in sedentary occupations. This study aims to investigate the therapeutic effects of two modern physical therapy techniques-Instrument-Assisted Soft Tissue Mobilization (IASTM) and percussion-based vibration therapy-on pain, functional capacity, proprioception, and kinesiophobia in individuals with cervical disc herniation.

A total of 66 participants diagnosed with cervical disc herniation will be recruited and randomly assigned to one of three groups: (1) Vibration Therapy Group, (2) IASTM Group, and (3) Conventional Exercise Group. All participants will receive standard physiotherapy, including thermotherapy, TENS, and range of motion exercises. Intervention groups will additionally receive either percussion massage therapy (3 sessions/week for 3 weeks) or IASTM (3 sessions/week for 3 weeks), targeting the cervical and upper back musculature.

Outcome measures will include the Visual Analog Scale (VAS) for pain, the Neck Disability Index (NDI) for functional assessment, a Laser Pointer Joint Position Sense Test for proprioception, and the Tampa Scale for Kinesiophobia (TSK) to assess fear of movement. The study seeks to compare the effectiveness of these approaches in improving clinical outcomes and contributing to evidence-based rehabilitation strategies for individuals with cervical disc pathology.

Eligibility Criteria:
Inclusion Criteria:

* Have a diagnosis of cervical disc herniation.
* Have a complaint of neck pain lasting at least 3 weeks.
* Have a restriction in cervical range of motion.

Exclusion Criteria:

* Have any additional orthopedic or neurological disorders besides cervical problems.
* Have a history of previous trauma to the cervical region.
* Have received physiotherapy within the past 6 months.
* Are unable to tolerate vibration therapy.
Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage

Spontaneous non-traumatic intracerebral hemorrhage (ICH) is a common symptom in clinical practice and is the most serious among all types of stroke.Recently, as a relatively mainstream and recognized INTERACT2 (five well-known international studies in the cerebrovascular field: IMS-III, MR RESCUE, SYNTHESIS EXPANSION, INTERACT2, CHANCE) studies have shown that in patients with standard systolic blood pressure Early intensive antihypertensive therapy does not increase the incidence of death or serious adverse events. The above studies confirm the safety and efficacy of early potent depression.In 2017, Anesthesiology published a META analysis of intraoperative hypotension and blood pressure versus baseline fluctuations. The final outcome showed that 20% of blood pressure in the study was similar to MAP \<65 mmHg, regardless of the duration of the duration There will be postoperative myocardial and renal damage. Ischemia is a very important cause of organ damage. Myocardial injury is closely related to the level of mean arterial pressure, while ischemia and ischemic reperfusion injury are closely related to postoperative acute renal injury.There is no targeted guideline for ICH perioperative blood pressure management, especially intraoperative blood pressure management, and no previous studies have studied most of the studies involving ICH patients with conservative treatment, ICH patients with surgical treatment There are few reports on blood pressure control during surgery.

The general anesthesia used in craniotomy, whether intravenous anesthesia or total intravenous anesthesia, have a certain degree of blood pressure and lead to a decline in blood pressure, the study aims to spontaneous cerebral hemorrhage this special And to observe the changes of hemodynamics and the changes of heart and kidney function in ICH, and to explore the relationship between the anesthesia and the blood of ICH. The range of volatility.

Eligibility Criteria:
Inclusion Criteria:

1. Age 18 years to90 years.
2. acute stroke symptoms caused by initial spontaneous intracerebral hemorrhage as determined by CT or MRI Blood: the screen area: 30-50ml; cerebellum parts:\> 10ml.
3. GCS score\> 5 points

Exclusion Criteria:

1. ICH is caused by other factors (anticoagulation associated with cerebral hemorrhage, arteriovenous malformations, tumors)
2. intracerebral hematoma is thought to be associated with trauma (simple intracerebral hemorrhage)
3. there are surgical contraindications.
4. history of ischemic stroke
5. acute spontaneous intracerebral hemorrhage before the presence of dementia or limb dysfunction (paralysis or aphasia.
6. preoperative combined with chronic kidney disease (standard for glomerular filtration rate below 60 ml · min-1 · 1.73 m2 or received dialysis).
7. anesthesia time shorter than 60 min or lack of relevant basic information.
8. while there is interference with the experimental results or follow-up of the disease (tumor, severe cardiovascular disease).
Seasonal Allergic Rhinitis and Driving Ability

On-the-road driving performance of untreated seasonal allergic rhinitis patients during the allergic season (exposed) is compared to driving performance outside the allergic season (in winter, not-exposed).

This study was set-up to examine whether untreated seasonal allergic rhinitis has an effect on driving ability. In addition to the driving tests, patients perform a memory test in the laboratory.

Eligibility Criteria:
Inclusion Criteria:

* outpatients with seasonal allergic rhinitis
* a valid driver's licence
* written informed consent
* a T5SS score \>8 during the allergic season and \<3 in winter

Exclusion Criteria:

* use of medication or medical conditions that are known to affect driving ability
* associated ENT disease or asthma
TAPB vs. Caudal for Lower Abdominal Surgery in Children: A Double-Blinded Randomized Controlled Trial

Transversus abdominis plane block (TAPB) has emerged as a safe and effective regional anesthesia technique for providing postoperative lower abdominal analgesia. Complications associated with TAPB are very rare and pose a lower overall risk to the patient receiving a TAPB versus a caudal block, which is considered the gold standard for pediatric lower abdominal regional anesthesia. Our study hypothesis was that TAPB would be equivalent to caudal block initially in providing postoperative pain control but would show improved pain relief beyond the anticipated caudal duration.

The study design was a double-blinded randomized controlled trial. A minimum of 44 children between the ages of 1 and 9 undergoing bilateral ureteral reimplantation surgery through a low transverse incision will be enrolled. Narcotic requirement, pain scores (FLACC/FACES), episodes of nausea/vomiting, and anti-spasmodic requirement will be recorded in the PACU and at 6 hour intervals through 24 hours from the time of the block placement.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 1 to 9 years old scheduled for intravesicular ureteral reimplantation surgery

Exclusion Criteria:

1. Coagulation status or anatomic variations precluded safe placement of either TAPB or caudal epidural,
2. there was a preexisting chronic pain disorder,
3. there was a history of constipation that persisted despite appropriate treatment and that may have impacted postoperative pain assessments,
4. additional procedures were planned via a separate incision at the time of the ureteral reimplantation, 5) there was a contraindication to receiving the medications described in the protocol.
Acute Effects of Artificial Sweeteners or Sugar on Hemodynamic and Metabolic Stress Responses

This exploratory study aims at investigating the acute effects of artificially sweetened and sugar beverage consumption (as compared to water consumption) on acute hemodynamic and metabolic stress response.

This single-center study included five visits. The first two visits (screening and familiarization) allowed checking the eligibility of the volunteers. In case of inclusion, the subjects were assigned to a sequence of three experimental conditions (water, sugar and artificial sweeteners), in a randomized, crossover design.

The experimental test was divided into 5 stages:

1. a 90 minutes baseline period (t=0-90 min),
2. a 30-min mental stress (MS; t=90-120 min), consisting in 5-min periods of Stroop's color word conflict test alternated with 5-min periods of mental arithmetic test.
3. a 30-min MS recovery period (t=120-150),
4. a 3-min cold pressure test (CPT) was carried out, aiming at immersing one volunteer's forearm in an ice water container at 3°C,

3) a 15-min CPT recovery period (t=120-150). 60 min after the beginning of the metabolic test, volunteers will drink 25 mL every 15 min, after 10-sec mouth rinsing, of either an artificially- or sugar-sweetened beverages or water (control).

Hemodynamic stress responses will be measured by repeated blood pressure, heart rate and cardiac output. Repeated venous blood samples will allow to assess metabolic stress responses.

Each condition (water, artificial sweeteners and sugar) will be preceded by a 2-day run-in period.

Eligibility Criteria:
Inclusion Criteria:

* Healthy
* Caucasian
* Normal Body Mass Index (18.5 ≤BMI≤ 25 kg/m2)
* Monophasic oral contraceptive

Exclusion Criteria:

* Hypertension (Blood pressure \>140/90 mmHg)
* History or actual psychologic/cardiovascular troubles
* Anemia anamnesis
* Being Pregnant
* Weight \< 50 kg
* Blood donation or participation to another study \< 8 weeks
* Claustrophobia
* Consumption of sugar/artifically-sweetened beverages drinks \> 5 dL/d
* Visual disturbances (daltonism)
* Low to moderate physical activity (\> 4h/wk)
* Smoker and narcotic consumption
* Caffeine (\> 400 mg/d) and/or alcohol (\> 10g/d) consumption
* Medical treatment
* Weight variation \> 3kg during the last month
How Seasons Affect Kidney Health in Post-Menopausal Females

The investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group. While heat stress can reduce kidney function, previous research has not accounted for physical activity, diet, hydration, or sun exposure.

Intense heat stress on the body can reduce kidney function. A recent study reported that blood markers of kidney function are lower among people in hotter climates. However, these data did not consider physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight. Therefore, the investigators invite participants to help determine whether there are seasonal changes in kidney function biomarkers. This will also help the investigators understand if physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight affect kidney function biomarkers between seasons. The investigators are studying female adults post-menopause since they are an understudied group.

Eligibility Criteria:
Inclusion Criteria:

* Female aged ≥55 years old
* Self Reported as at least one year post-menopause
* Live in Tallahassee, Florida, or the surrounding area

Exclusion Criteria:

* Have a BMI of ≥30 kg/m2
* Systolic blood pressure of ≥140 and/or diastolic blood pressure ≥90 mmHg
* Self Reported Current or recent (regular use within the past six months) use of a diuretic medication
* Self Reported: Uncontrolled cardiovascular, respiratory, neurological, renal, liver, or metabolic health condition
* Current or recent (regular use within the past six months) use of tobacco, nicotine, nonsteroidal anti-inflammatory products
* No regular (≥once per week) purposeful heat exposure (e.g., sauna, spa, etc.)
Computer-Assisted, Game-Based Cognitive Training on Attention

The aim of this study was to investigate the effect of 8 weeks of cognitive training on attention function in healthy young people.


Eligibility Criteria:
Inclusion Criteria:

* Those between the ages of 21-24,
* No communication problem,
* Not continuing any exercise program for the last 1 year,
* Having a smart phone, tablet or computer required to participate in the training program,
* Individuals who volunteered to participate in the study.

Exclusion Criteria:

* Having vision and hearing problems,
* Individuals who continued the physical exercise program and/or had hobbies such as puzzles and jigsaw puzzles that could affect the cognitive level.
Compare Effectiveness of Eplerenone vs Atenolol in Reversing the Remodelling Resistance Arteries in Subjects With HT

To investigate the impact of antihypertensive therapy with the selective mineralocorticoid receptor blocker, eplerenone, on small resistance artery remodeling, compared to the effect of equivalent blood pressure control achieved with a b-blocker, atenolol.


Eligibility Criteria:
Inclusion Criteria:

* Pt with essential hypertension who have never been treated or untreated within the previous 6 months

Exclusion Criteria:

* History of Malignant Hypertension
* Sitting diastolic blood pressure \> 115mmHg or sitting Systolic blood pressure \> 200mmHg
The CloudUPDRS Smartphone Software in Parkinson's Study.

This study compares the validity and usability of smartphone software for home monitoring of symptoms and signs in Parkinson's disease as compared to the current clinical gold standard - the Unified Parkinsons Disease Rating Scale.

Parkinson's Disease (PD) is a neurodegenerative condition, which when treated can result in fluctuating motor activity - sometimes too much movement, sometimes too little.

A series of tests, run on a smartphone, will be used to evaluate the motor signs of Parkinson's and related to a clinical evaluation based on the Unified Parkinson's Disease Rating Scale. 60 participants will be recruited.

Eligibility Criteria:
Inclusion Criteria:

1. Diagnosed with probable idiopathic Parkinson's Disease according to Brain Bank criteria (Gibb and Lees, 1988).
2. Over 18 years old.
3. Achieve \>20/30 on the Montreal Cognitive Assessment (MOCA).
4. They must have been on the current Parkinson's Disease medication schedule for at least a week and have no plans to change this during the period of testing.
5. They must have the capacity to consent to take part in the study.
6. They must be able to understand English to the level of being able to operate the phone software, follow its instructions and be able to answer the study questions.

Exclusion Criteria:

1. Acute medical illness.
2. Any other co-morbidity that in the opinion of the Investigator may preclude their participation in the study.
3. Unable to consent to the study.
Trending of Respiratory Rate Using the Nellcor™ Bedside Respiratory Patient Monitoring System

This is an open-label, non-randomized, prospective, descriptive study of the Nellcor™ Bedside Respiratory Patient Monitoring System using the Nellcor™ Respiration Rate parameter and Nellcor™ Adult Respiratory Sensor The study is intended to gain further information in the clinical space on the function of the Nellcor™ Respiration Rate parameter. The primary objective is to describe spot check (e.g. manual observation) of respiration rate versus cumulative automated counting (trend) of respiratory rate as measured using the Nellcor™ Bedside Respiratory Patient Monitoring System with the Nellcor™ Respiration Rate parameter.


Eligibility Criteria:
Inclusion Criteria:

1. 18 years or older.
2. A patient who meets the weight requirement for the sensor (e.g. \>30kg).
3. A patient at the study site on a General Care Floor (surgical or medical/non-surgical to be distributed equally) and prescribed standard vital sign checks.
4. Patient is willing and able to provide written informed consent.

Exclusion Criteria:

1. Expected length of stay is \< 4 hours.
2. Patient is pregnant or lactating.
3. Patient has severe contact allergies that may cause a reaction to standard adhesive materials found in pulse oximetry sensors, ECG electrodes, respiration monitor electrodes or other medical sensors.
4. Patient has an abnormality that may prevent proper application of the device.
5. Patient is in atrial fibrillation.
6. Patient has a documented history of frequent premature atrial contractions (PACs) or premature ventricular contractions (PVCs), defined as greater than 3 in 30 seconds or greater than 6 in 60 seconds within the past 3 months.
7. Patient has an implanted pacemaker.
8. Patient has excessive nail polish that cannot be removed or other dye or discoloration of the finger.
9. Patient has diagnosed central apnea or diagnosed significant obstructive sleep apnea.
10. Patient is currently using continuous positive airway pressure (CPAP).
11. Patient is unwilling or unable to sign informed consent.
12. Evidence that the patient cannot understand the purpose and risks of the study and would require a legally authorized representative to sign informed consent.
13. Patient is participating in another potentially confounding clinical study.
14. Extreme motion conditions such as patient is prescribed to walk more than once per hour or is prescribed a medical device resulting in constant movement.
Benfotiamine Prevents Vascular Dysfunction in Healthy Smokers

Benfotiamine pretreatment (3 days)at high dosage (1050 mg/day) prevents in healthy subjects smoking-induced vascular dysfunction assessed by ultrasound flow mediated dilatation of the brachial artery.

Benfotiamine pretreatment (3 days)at high dosage (1050 mg/day) prevents in healthy subjects smoking-induced vascular dysfunction assessed by ultrasound flow mediated dilatation (FMD) of the brachial arteryand laboratory parameters (adhesion molecules).

Eligibility Criteria:
Inclusion Criteria:

* healthy habitual smokers

Exclusion Criteria:

* any kind of chronic disease
Guided Versus Conventional Periapical Endodontic Surgery

This study is to compare the clinical and radiographic outcomes after guided periapical endodontic surgery versus conventional endodontic surgery.

The aim of this study is to compare the clinical and radiographic outcomes after guided periapical endodontic surgery versus conventional endodontic surgery. Patients having mandibular posterior teeth indicated for endodontic surgery will be selected. Full medical and dental history will be obtained from all patients. Patients will be randomly assigned to either guided endodontic surgery or conventional endodontic surgery. Surgical procedures will be done under magnification. Root-end cavities will be filled using MTA.Post surgical instrucions will be given to patients. Surgical time will be recorded. Clinical and radiographic success will be asses at 6 and 12 month.

Eligibility Criteria:
Inclusion Criteria:

1. Patients in good general health.
2. Patients with age ranging between 18-50 years with no sex predilection.
3. Posterior teeth with an indication for endodontic surgery.
4. Patients' acceptance to participate in the study.

Exclusion Criteria:

1. Patients with allergy to materials or medications used in the trial.
2. Pregnant female patients.
3. Teeth with pathoses associated with vertical root fracture.
4. Severe periodontal bone loss detected with a periodontal probe (5 mm probing depth).
A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT)

The purpose of this study is to demonstrate that the strength of agreement between single photon emission computed tomography (SPECT) imaging with regadenoson following inadequate exercise stress testing and SPECT imaging with regadenoson alone is not inferior to the strength of agreement between two sequential regadenoson SPECT images without exercise.


Eligibility Criteria:
Inclusion Criteria:

* Subjects referred for an exercise or pharmacologic stress test SPECT MPI procedure for the evaluation of coronary artery disease (CAD) are eligible for study participation. Subjects referred for pharmacologic stress should have a reasonable potential of attempting exercise stress. Subject must have one of the following:

  * a. Past ischemia on any prior imaging stress test without invasive intervention on the artery subtending this territory
  * b. Subject with known CAD who have symptoms similar to previous ischemic symptoms, or recent onset of symptoms or recently worsened symptoms suggestive of ischemia
  * c. Diamond Forrester estimated pretest probability of CAD of ≥ 50%
  * d. History of most recent coronary artery bypass surgery or most recent percutaneous coronary intervention (PCI) \> 10 years (patients who are \> 30 days but less than 10 years post coronary artery bypass graft (CABG) or PCI can be included if they meet criteria a, b, or e)
  * e. Previously demonstrated 100% occlusion by invasive coronary or computed tomography (CT) angiography without successful intervening revascularization as these foods may alter regadenoson effects

Exclusion Criteria:

* Subject has a clinically significant illness, medical condition, or laboratory abnormality
* Female subject who is pregnant or lactating
* Subject is on dialysis for end stage renal disease or has a history of glomerular filtration rate (GFR) \< 15 mL/min (calculated using MDRD \[Modification of Diet in Renal Disease\] formula)
* Subject has a history of coronary revascularization by either PCI or CABG within 1 month prior to the rest myocardial perfusion imaging (MPI)
* Subject has a pacemaker or an implantable cardioverter defibrillator (ICD)
* Subject has a history of acute myocardial infarction (MI) or high risk unstable angina within 30 days prior to the rest MPI or has had cardiac transplantation
* Subject has uncontrolled hypertension at any point on Visit 2 prior to exercise testing (i.e., systolic blood pressure (SBP) ≥ 180 or diastolic blood pressure (DBP) ≥ 95 mmHg on two consecutive measurements while at rest).
* Subject has severe aortic stenosis or hypertrophic cardiomyopathy with obstruction or has decompensated congestive heart failure
* Subject has a history of severe respiratory disease including: asthma, chronic obstructive pulmonary disease (COPD) or other bronchospastic reactive airway disease or who is on 24-hour continuous oxygen