cyrilzakka/clinical-trials huggingface dataset:
Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD

The purpose of this study is to determine whether it is more effective to treat adolescents, with diagnoses of both depression and substance use disorder, with a treatment addressing the substance use first and then treating the depression or to first treat the depression and then treat the substance use or whether treating both disorders simultaneously is most effective.

It is expected that treatment of both disorders at the same time will be the most effective.

Comorbidity is a well established aspect of adolescent psychopathology. The majority of adolescents entering treatment have more than one condition. This study will evaluate service delivery methods of integrating empirically supported interventions for depression and non-nicotine substance use disorders (SUD)in an effort to improve treatment engagement, response, and maintenance of gains. The two examined interventions are the Adolescent Coping With Depression course (ACWD) and Functional Family Therapy (FFT).

This study will expand upon previous research by systematically treating both depression and SUD. Over a 5 year period, 180 adolescents with depression/SUD and their parents/guardians will be recruited in Oregon and New Mexico and randomly assigned to 1 of 3 conditions: (a) FFT followed by ACWD, (b) ACWD followed by FFT, or (c) an intervention combining and augmenting FFT and ACWD (Integrated Treatment). Each treatment arm will consist of 24 sessions provided over 20 weeks. Participants will be assessed at intake, after the provision of 6, 12 (Mid-treatment), 18 and 24 (Post-treatment)treatment sessions, and at 6 and 12 month follow-ups.

Eligibility Criteria:
Inclusion Criteria:

1. DSM-IV-TR diagnosis of depression, defined as MDD, dysthymia, or substance-induced mood disorder meeting MDD or dysthymia symptom criteria
2. DSM-IV-TR diagnosis of one or more non-nicotine SUD
3. Some reported illicit drug use in the last 90 days
4. 13-17 years of age
5. parent or guardian willing to participate in study
6. basic English competency (ability to converse in English)

Exclusion Criteria:

1. Current and acute suicidal ideation at the level warranting inpatient treatment
2. current psychotic symptoms
3. the adolescent's sibling is already participating in the study
4. if on psychiatric medications, a significant change in dosage levels in the prior 4 weeks -
Systematic Transcutaneous Oxymetry Use in Thoracic Outlet Syndrome

The measurement of the transcutaneous oxygen partial pressure (TCPO2) at exercise is, to our knowledge, the only method to estimate during the exercise the importance of ischemia segment of limb by segment of limb bilaterally and carry on. The diagnosis of thoracic outlet syndrome causing remains difficult and dependent operator in ultrasound because of the risk of false positive (loss of signal) or false negative (insufficient effort, inappropriate movement).

Our main hypothesis is the existence of significant measurable ischemia in the forearm by transcutaneous oximetry during the maneuvering of the "candlestick".

In the event of failure of this maneuver, the other maneuvers such as those of Wright, Roos, Tinel and Adson will be realized.

In this study we want to evaluate the possibility of using dynamic transcutaneous Oximetry as a tool for evaluating ischemia in case of suspicion of thoracic outlet syndrome causing.

Patients referred for suspected thoracic outlet syndrome causing and healthy asymptomatic subjects will be included.

After signing the consent, the subject will have a clinical and paraclinical examination. Age, sex, height, weight, side of clinical symptomatology will be collected. Medical history current treatments will also be noted.

The examination of transcutaneous oximetry dynamic measurement with palmar face of both forearms during two consecutive maneuvers known as the "candlestick" (hands up). The most symptomatic arm value in patients and the dominant arm in the control group will be noted. In case of DROP between 0 and -25 mmHg, in addition to the maneuvering of the "candlestick", the other maneuvers such as those of Wright, Roos, Tinel and Adson will be realized.

The results of any additional examinations and / or pre- and post-operative consultations will be collected.

Subjects complete two Quality of Life questionnaires: the SF-12 (Short Form 12) and the DASH questionnaire (Disabilities of the Arm, Shoulder and Hand).

Added by an amendment : Photoplethysmography has already done its proofs to determine the thoracic outlet syndrome diagnotic. Combine with a camera Kinect, they should determine the angle of appearance of compression in the 3 dimensions of space.

Eligibility Criteria:
Inclusion Criteria:

* subjects referred for investigation of thoracic outlet syndrome causing
* Affiliation to the French National healthcare system
* French speaking patients
* Ability to stand still for half a minute

Exclusion Criteria:

* pregnancy
* inability to understand the study goal
* Patients protected by decision of law
The Risk Factors of Thrombosis in Complicated Arteriovenous Fistula

study the risk factors of thrombosis in thrombosed arteriovenous fistula in patients on regular hemodialysis

The number of patients being treated for kidney failure continues to increase every year at a significantly higher rate than that of the world population.

The main renal replacement therapy was hemodialysis (HD) in 57% patients and peritoneal dialysis in 5% patients, while 37% patients underwent a functional kidney transplant.

Native arteriovenous fistula (AVF) is currently the best VA when technically feasible, according to the international dialysis guidelines.

Hemodialysis vascular access failure is the dominant cause of morbidity and the major cost of care for end-stage renal disease (ESRD) patients .

Complications such as thrombosis of VA remain the main problem for many patients with kidney failure.

Since 1994, prospective and case-control studies have explored the relationship between risk factors and arteriovenous fistula thrombus (AVFT) in patients undergoing HD .

Until now, these studies and reviews have revealed that numerous risk factors are associated with AVFT .

Risk factors like arterio-venous graft, age, female sex, C-reactive protein level, fistula site (distal), hypertension and the use of eprex can be associated with AVFT, and this knowledge advances the understanding of AVFT, facilitates multivariable risk prediction profiling, and lays the foundation for future preventive strategies .

Eligibility Criteria:
Inclusion Criteria:

* All patients on maintenance hemodialysis treatment at the dialysis unit of the department of nephrology in Assiut University Hospital .

Exclusion Criteria:

* Patients with known other risk factors of thrombosis, e.g., malignancy, pregnancy, cocs and nephrotic syndrome.
Vibration Therapy in Wheelchair Basketball Players

No study was found that investigated the effect of vibration therapy (VT) on recovery from exercise in WCB players. Therefore, the aim of the study was to investigate the effects of wearable local vibration device on muscle soreness and athletic performance during recovery from exercise in the elbow area in WCB players.

Vibration therapy (VT) has been widely used to increase performance and rehabilitate injuries in athletes. Delayed onset muscle soreness (DOMS), caused by excessive overload after training and competitions, leads to loss of performance. The aim of this study was to investigate the effects of wearable local VT on muscle soreness and athletic performance in wheelchair basketball (WCB) players.

Eligibility Criteria:
Inclusion Criteria:

* Being a wheelchair basketball players

Exclusion Criteria:

* Having had an upper extremity operation within the last 6 months
Opioid Free Anesthesia and Major Spine Surgery

This study compares the intraoperative opioid free anesthesia approach in multilevel spine posterior instrumentation surgery to a conventional opioid-based anesthesia. Half of participants will receive opioid free anesthesia with dexmedetomidine, lidocaine and ketamine while the other half will receive opioid based anesthesia with fentanyl, remi-fentanyl and ketamine

Opioid analgesics are commonly used in clinical practice for per and postoperative pain treatment. However their use is associated with a lot of undesirable effects. From this comes the idea of using opioid free anesthesia intra-operatively in an attempt to decrease opioids postoperative use and accordingly, their associated side effects.

Intravenous (IV) lidocaine has been found to have analgesic, antihyperalgesic, and anti-inflammatory properties. It was found to significantly improve postoperative pain, when its intraoperative use was compared with placebo .

Dexmedetomidine is a selective alpha-two adrenergic receptor agonist that has antinociceptive, analgesic, opioid sparing and sedative properties. Similar to lidocaine, dexmedetomidine was shown to lower postoperative pain, opioid consumption and accordingly, opioid related side effects.

Eligibility Criteria:
Inclusion Criteria:

* Age group: 18-80 years old
* American Society of Anesthesiologists (ASA )class I, II and III
* Elective spine posterior instrumentation surgery of at least two levels.

Exclusion Criteria:

* Renal, hepatic or cardiac insufficiency.
* Alcohol or drug abuse.
* Psychiatric disease.
* Allergy or contraindication to any of the study drugs.
* Inability to comprehend pain assessment or inability to use a Patient Controlled Analgesia (PCA) device.
Artificial Intelligence System in Medical Regulation

Population health needs are increasing. Information and communication technologies are changing. The digital shift offers new opportunities for the exploration and analysis of mass health data. It is possible to rely on these new technologies to modernize, optimize patient management at the level of emergency medical communication centres.

Our project aims to integrate the methods and tools of artificial intelligence for emergency medical communication centres. The system aims to help regulate emergency calls at CRRA 15 in France, or Centrale 144 in Switzerland, to assess the severity of calls, identify care pathways, and improve efficiency when committing resources.

The development of such a system is aimed at securing and optimising the information system and the means of telecommunication used in the emergency medical communication centres, and provide an individualized response to the patient management.


Eligibility Criteria:
Inclusion Criteria:

* all patient which call the emergency medical communication centres

Exclusion Criteria:

* patient opposed to the study
Causes and Underlying Factors of Faltering Growth Among Infants

to research in the different causes of failure to thrive in children including organic and non organic causes

Altered growth velocity in infants has been traditionally described by the term (failure to thrive ) . More recently the preferred terms are faltering growth ,slow weight gain or undernourishment as failure to thrive has been associated with negative connotations of parents failing in their job as careproviders.

The expression 'to falter' means to hesitate. Faltering growth is an observation,without value judgement, of slower than expected rate of growth along an infant's previously defined growth curve.

Faltering growth is a common pediatric problem with many untoward effects . More studies showed that children who failed to thrive in infancy are lighter and shorter at school age with adverse intellectual outcomes (corbett and drewett,2004)(Natale etal., 2014). Weight faltering in the first months of life is particularly associated with these adverse effects.

Infants with faltering growth also have a higher prevalence of feeding problems (Young etal., 2013).Growth failure is more common during infancy than during any other stage of life because programmed growth rates and nutritional needs are high (

Eligibility Criteria:
Inclusion Criteria:

:Infants attending assiut university children hospital who are stunting(decrease height for age ), wasting(decrease weight for lenght ), and underweight (decreases weight for age ) . When all of theses less than -1 Z scores (normal Z-score from -1 to +1 ) . Also mid arm circumference below than 115 mm

Exclusion criteria:

Children complaining of any of the follolowing:

* Malignancy
Peripheral Venous Stent System in the Treatment of Iliac Vein Stenosis or Occlusion

Clinical study on safety and efficacy of Zylox peripheral venous stent system in the treatment of iliac vein stenosis or occlusion.

The purpose of this study was to evaluate the safety and efficacy of Zylox peripheral venous stent system in the treatment of iliac vein stenosis or occlusive lesions compare with conventional venous stent.

Eligibility Criteria:
Inclusion Criteria:

* Aged from 18 to 75 years old, male or female
* Subject's target lesions were stenosis and/or occlusion
* CEAP≥C3
* Subjects were able to understand the purpose of the study, demonstrate full compliance with the program and sign informed consent

Exclusion Criteria:

* Pregnant woman or who's pregnancy test is positive
* Lactation period woman or woman/man with fertility plan
Transplantation of Autologous Bone Marrow Derived Stem Cells in Patients With Rheumatoid Arthritis

Rheumatoid arthritis is a chronic systemic disease, which is characterized by chronic inflammation in the synovial tissue. Rheumatoid arthritis ultimately results in the destruction of cartilage, bone and ligaments and joint deformity. The underlying hypothesis is that autologous bone marrow-derived mesenchymal and specific populations of stem cells has anti-inflammatory and regenerative effects and thus potentially alleviates the progression of rheumatoid arthritis. The study is to explore the safety and efficacy of BM-SC transplantation in treatment of rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that primarily affects joints. It typically results in swollen and painful joints. Pain and stiffness often worsen after rest. Most frequently, the wrist and hands are involved, with the same joints typically involved on both sides of the body. RA affects between 0.5-1% of adults in the developed world with between 5-50 per 100,000 people newly developing the disease each year. Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. The goal of treatment is to reduce pain, decrease inflammation, and improve a person's overall functioning and quality of life.

Herein, the investigators study the safety and efficacy of the immunomodulatory effects of bone marrow-derived stem cells administered intravenously and the regenerative and repair potential of bone marrow-derived stem cells transplanted into the joints of patients with RA.

Eligibility Criteria:
Inclusion Criteria:

* 17-75 years old
* The presence of osteoarthritis based on MRI and American Rheumatism Association criteria since 6 months before treatment.

Exclusion Criteria:

* Subjects with addition major health condition/disease diagnoses
* Subjects that are pregnant or breastfeeding
The Patient's Experience With Physician Assistant Providers (PEPAP)

Our investigation was a prospective cross-sectional survey evaluating the patient experience to new patients that presented to an outpatient private practice specialized in total joint reconstruction. New patients seeing a PA during their initial visit were randomized to intervention and control groups and all were given a descriptive survey at checkout. Inclusion criteria (1) new patient (2) English speaking (3) appointment with PA. There was no exclusion criteria. Eligible patients were randomized to the intervention group (received biosketch card) or the control group (no card) using random number generator. Patients within the intervention group received a biosketch card during rooming, pre-clinician encounter, and were not informed about involvement. Both groups received standard care that was independent of the study. To blind the outcome measure, the research assistant did not explain the reason for the card upon rooming. The provider PA was not informed which patient received the card. Upon discharge, the patient completed a five-question survey regarding the clinic visit.


Eligibility Criteria:
Inclusion Criteria:

* New Patient
* Appointment with a PA

Exclusion Criteria:

* Non-English Speaker
Ginkgo Biloba Extract in the Treatment of Schizophrenia

We investigated the effects of Ginkgo biloba extract on the symptoms and cognitive functioning in patients with schizophrenia

Objective: This study aimed to evaluate the effect of Ginkgo biloba extract in the treatment of symptoms and cognitive functioning in 200? chronic patients with schizophrenia

Methods:

1. Clinical Trial: This is a randomized, double-blind and parallel controlled trial in the chronic patients with schizophrenia. The study consists of 12 weeks of double-blind treatment.
2. Assessment Procedures:

2.1 Primary Outcome Variable: Patients were assessed by two clinical trained staff, who were blind to the treatment protocols, by using the Positive and Negative Syndrome Scale (PANSS) to assess the psychopathology and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to evaluation the cognitive functioning. Patients were interviewed at screening, and at baseline, 4? weeks, 12? weeks.

2.2 Side effects: The side effect rating scale (UKU) was used to assess the side effect at baseline, 4? weeks, and 12? weeks.

2.3 Weight gain measurement: weigh was measured every week.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of schizophrenia by two senior psychiatrists
* Between 18 and 60 years and Han Chinese
* Duration of symptoms at least 12 months
* Current psychotic symptoms of moderate severity

Exclusion Criteria:

* A Diagnostic and Statistical Manual of Mental Disorders IV Axis I diagnosis other than schizophrenia
* Documented disease of physical diseases including, but not limited to stroke, tumor, Parkinson's disease, Huntington's disease, seizure, epilepsy, history of brain trauma；
* Pregnant or breast-feeding female'
* Subjects who suffered from alcohol or illegal durg abuse/dependence
The Treatment Effect of Bio-Three on Children With Enteritis

Diarrhea due to acute enteritis is a common symptom in the children. Lots of patients are infected by rotavirus or salmonella.

Base on the past researches, there is benefit effect of probiotics on patients with diarrhea or acute enteritis. In this clinical study, bio-Three, a probiotic which contains three independent probiotics, will be used in patients with acute diarrhea.

This is a single site, controlled clinical research. About 80 patients will be enrolled into this study to evaluate the benefit effect of bio-Three among patients with acute enteritis due to rotavirus or salmonella or other unknown reason. Patients will be diagnosed and screened by inclusion and exclusion criteria and only eligible patients will be enrolled into this study.

Intervention: Subjects were randomly assigned to receive control treatment (intravenous fluid, oral rice and half strength milk formula) or add-on treatment of the probiotics (Bio-three®) to the control treatment.

Main outcome measures: Quantitative Vesikari scales and qualitative severe diarrhea (Vesikari scale≥11) Exclusion criteria included immunodeficiency, severe abdominal distension with risk of bowel perforation, severe infection or sepsis, history of gastrointestinal tract surgery, and probiotics use in the preceding 1 week.

Eligibility Criteria:
Inclusion Criteria:

* Clinical symptom of diarrhea less than 3 days

Exclusion Criteria:

* Severe abdominal distension with risk of bowel perforation
* Risk for sepsis
* Past history with surgical operation of gastrointestinal tracts
* immunodeficiency
* probiotics use in the preceding 1 week
Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment

Purpose: To evaluate the logical surgical approaches in closing macular holes in eyes of proliferative diabetic retinopathy with retinal detachment

High MH closure rate can be achieved. Other than high myopia, MH with RD may appear in several conditions, such as severe vitreomacular traction, proliferative diabetic retinopathy (PDR).clinical charts were reviewed of patients of proliferative diabetic retinopathy suffering from MH with RD who were treated with vitrectomy combined with inverted epiretinal ILM flap,inverted ILM flaps insertion techniques, or free ILM flaps.Standard 3-port 23 or 25 gauged pars plana vitrectomy was performed. After core vitrectomy, anterior-posterior oriented tractions as well as all fibrovascular tissues were removed as thoroughly as possible.The patients were kept in a facedown position overnight and were allowed to take any positions except supine for approximately one week.Various surgical approaches utilizing in managing macular hole may effectively closing macular holes and reattach retina.

Eligibility Criteria:
Inclusion Criteria:

* Patients were proliferative diabetic retinopathy suffering from MH with RD.

Exclusion Criteria:

* Patients were not proliferative diabetic retinopathy suffering from MH with RD.
A Multicenter Prospective Observational Cohort Based on a Breast Cancer Medical Record Database in China

1. To construct a prospective, multi-center breast cancer treatment cohort in China, and analyze the factors affecting breast cancer diagnosis and treatment.
2. To evaluate the diagnosis and treatment and prognosis of breast cancer among patients in different regions and hospitals.

This research aims to:

A. Understand and analyze the current status of breast cancer diagnosis and treatment; B. Publish an annual report on diagnosis and treatment; C. Data sharing, dynamic evaluation; D. Evaluate consensus and guideline promotion and implementation effects; E. Propose and set clinical quality standards for industry associations, and propose improvement goals; F. Provide a basis for industry associations to formulate specialized training programs; G. To provide assistance in the formulation of health insurance policies; H. Provide a platform for clinical research on breast cancer; I. Provide evidence for the formulation of clinical guidelines and consensus

Eligibility Criteria:
Inclusion Criteria:

* Patients with malignant breast tumors must be diagnosed by cytology or histology, and their pathological types include but are not limited to breast carcinoma in situ, invasive carcinoma, and breast sarcoma.

Exclusion Criteria:

* None