cyrilzakka/clinical-trials huggingface dataset:
Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates

The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation. The current protocol for coronary artery disease assessment at UCSF before liver and lung transplantation involves screening with stress tests and/or coronary angiograms in patients with increased risk of coronary artery disease. Coronary angiogram will be used as gold standard for assessment of coronary CTA accuracy.


Eligibility Criteria:
Inclusion Criteria:

1. Liver transplant candidates referred for invasive coronary angiography which include:

   * Patients with suspicious symptoms for CAD or;
   * Asymptomatic patients;
   * Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF \< 60% on echo.
2. Lung transplant candidates referred for invasive coronary angiography which include:

   * Patients with suspicious symptoms for CAD or;
   * Asymptomatic patients;
   * Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF \< 60% on echo in patients with low SVR (typical for ESLD).
3. Any ethnic background is acceptable.

Exclusion Criteria:

1. Patients with contraindications for the use of iodinated contrast (allergic reaction, renal failure, multiple myeloma, etc) will be excluded.
2. Children and pregnant women will be excluded because of risks associated with radiation exposure.
3. Patients must have no atrial fibrillation, as this will interfere with cardiac gating for the examination.
4. Patients unable to give informed consent will be excluded as well.
A VR Intervention for Prosocial Behavior and Well-being Among Adolescents

The aim of this project is to examine the effectiveness of a gamified prosocial VR intervention.

There are two parts in this study. In the first part of the study, participants will be first directed to complete a background survey online (approximately 20 minutes). In the second part of the study, participants will participate in a 5-session gamified training program, one session a week for five consecutive weeks, each session lasts between 10-15 minutes. Upon completion of each session, participants will be required to complete a short 5-minute online survey. A daily diary study will be conducted during the intervention to monitor the nuance behavioral and attitudinal changes.

Eligibility Criteria:
Inclusion Criteria:

* School students aged 10-16 (i.e., primary 5 to secondary 5);
* Able to communicate in Chinese.

Exclusion Criteria:

* Significant cognitive impairment;
* Self-reported severe motion sickness;
* Uncorrected visual impairment.
Handwriting Analysis in Movement Disorders.

Movement disorders are a group of neurological conditions that cause problems with movement, either in the form of excessive, reduced, or slow movements. Some commonly known movement disorders include Parkinson disease, dystonia, ataxia, and Tourette syndrome. Multiple movement disorders have unique handwriting characteristics that can be measured using an inkless pen and a digitalized tablet. Handwriting is a complex skill that requires a combination of cognition, motor planning, and visuomotor integration. Handwriting deteriorates in patients with neurodegenerative diseases.

This study aims to discern variations in the kinematics (movement patterns) involved in handwriting between individuals with movement disorders and healthy controls. Participants will be invited to carry out a series of handwriting tasks. The pen motions will be captured using an inkless pen and a digitizing tablet linked to a laptop. The entire set of tasks is designed to be completed within 30 minutes. The data will then be collected, processed, and analyzed utilizing a handwriting analysis software.

Background: Handwriting is a complex skill that requires a combination of cognition, motor planning, and visuomotor integration. Various brain structures including the cerebral cortex, basal ganglia, and cerebellum are involved in learning and performing handwriting. Many neurological disorders impact these brain structures in unique ways, leading to distinct effects on handwriting. Changes in handwriting performance are a prominent feature of Parkinson disease (PD), ataxias, and other movement disorders. Handwriting analysis can serve as a tool to distinguish and monitor the progression of movement disorders. Patients suffering from PD exhibit impairments of previously learned motor skills, including handwriting. It has been demonstrated that patients in the early stages of Parkinson disease exhibit variations in handwriting when compared to healthy individuals. The current research will investigate kinematics, visuospatial adaptation, and learning in different movement disorders through handwriting analysis.

Data collection and Measurement techniques: The subject will be seated comfortably at a table with the digitalized tablet positioned to allow a natural writing position for the subject. Pen movements will be recorded using a non-inking pen and Wacom Cintiq 16-inch digitizing tablet connected to a laptop. A practice session will be provided to each participant to familiarize them with the inkless writing pen and tablet. Before each task, participants will be given instructions on how to perform the task. Participants will be instructed to complete several writing exercises aimed at evaluating various aspects of their handwriting skills. Each task will be repeated multiple times and the entire set of handwriting exercises will be completed within 30 minutes.

Eligibility Criteria:
Inclusion Criteria:

(1) Diagnosed with a movement disorder.

Exclusion Criteria:

1. Action tremor or weakness in the dominant hand interfering with writing task.
2. Unable to write or understand English
The Factors That Affect the Infection of COVID-19

The number of new Coronavirus-2019 (Covid-19) cases is increasing day by day despite the warnings "Stay at home! Wear a mask! Keep social distance!". The aim of this descriptive study is to determine the risk factors that affect the Covid-19 infection in Turkey.

The online link of the form created on Google forms was sent to the participants' phones between 18.10.2020 and 18.11.2020.

The number of new Coronavirus-2019 (Covid-19) cases is increasing day by day despite the warnings "Stay at home! Wear a mask! Keep social distance!". The aim of this descriptive study is to determine the risk factors that affect the Covid-19 infection in Turkey.

The majority of the lands within the Republic of Turkey cover Anatolia, while a minor part covers Thrace, the southeast extension of the Balkan Peninsula. The population of Turkey is 83,154,997. Based on the natural, human and financial characteristics, the country consists of seven regions: Mediterranean, Eastern Anatolia, Aegean, Southeastern Anatolia, Central Anatolia, Marmara, and Black Sea. The majority of the population lives in the Marmara Region. The online link of the form created on Google forms was sent to the participants' phones between 18.10.2020 and 18.11.2020 and participants' informed consent was obtained.

A 43-item questionnaire form which had two sections and was prepared by the researcher in line with the literature was used in data collection. The first section questioned participants' personal characteristics (first letters of participants' names and surnames, date of birth, profession, employment status, risk of Covid-19 infection, family type, etc.), while the second section questioned the practices of following 14 rules declared by the Turkish Ministry of Health to prevent the Covid-19 pandemic (using a mask, observing the hand hygiene and social distance, etc.) and whether participants were diagnosed with Covid-19. Identity details that could help identify the participants were not questioned.

Eligibility Criteria:
Inclusion Criteria:

* Being over the age of 18
* Be in good mental and mental health
* To be able to read and write

Exclusion Criteria:

* Being under the age of 18
ERAS Swallowing Rehabilitation in Elder Patients

The investigators studied that swallowing function of patients receiving the Early Recovery Accelerated Swallowing (ERAS-W program) training will recover fast than that of patients in the control group. The ERAS program training will be initiated before surgery and continue to after surgery.

The older patients (≥65 years old) with OFI-8≥4 undergoing elective orthopedic surgery requiring tracheal intubation will be recruited. Patients will be randomized into an intervention and a control group. Patients in the intervention groups will received the ERAS-W program, while those in the control group will receive the swallowing education video.

Eligibility Criteria:
Inclusion Criteria:

* elective surgery
* general anesthesia with endotracheal intubation

Exclusion Criteria:

* major organ dysfunction, ex: chronic kidney disease, hear failure
* bleeding tendency
Epidemiological Observatory on the Health Conditions of Inpatients Aged 65 or Older at the INRCA Research Hospitals

The goal of this research study is to collect clinical data, comprehensive geriatric assessment, risk factors, biological data and blood samples from inpatients aged 65 and older at the INRCA research hospitals (Italy). All data will be stored in a research bank and used to better clarify the mechanisms underlying the condition of "frailty" in aged patients. The database will be created on the INRCA server platform by establishing a safe HTTPS protocol.

Life expectancy is continuously increasing in Italy. Aging is generally linked to adaptive modifications of organs and systems that reduce the functional reserve and increase the vulnerability to disease and addiction. This framework constitutes the condition of "frailty", which is associated to an increased risk of multiple adverse events as falls, fractures, disability, institutionalisation and death. To reduce the burden of disability and diseases affecting the quality of life of the elderly and, at the same time weighs heavily on health costs, a high level of managerial efficiency has to be achieved, planning the necessary health and care services and implementing measures to prevent disability in the fragile elderly. Indeed a strongly expanding area of gerontological and geriatric research is focusing on successful aging, that is characterised by a low probability of diseases and related disabilities, by a high level of physical and cognitive functionality and by an active social involvement in daily life. For this reason the project is based on the implementation of a validated system of comprehensive geriatric assessment able to provide detailed measures of the different possible interactions among risk factors. The study aimed at the descriptive-epidemiological collection of the health conditions of older in-patients at the different INRCA research hospitals (Italy). The data set will include personal data, information from the comprehensive geriatric assessment, clinical-care, biological and diagnostic data, collected routinely as well as ad hoc during hospitalisation. Moreover, a blood sample will be taken to performing biomarkers and genetic analyses.

Eligibility Criteria:
Inclusion Criteria:

* Aged 65 or older
* Inpatients at the different INRCA research hospital facilities (Italy)

Exclusion Criteria:

* Inpatients who have not/for those the informed consent was not given
Randomized-controlled Trial of Preoperative Inspiratory Muscle Training on Postoperative Complications

Rehabilitation strategies after abdominal surgery enhance recovery and improve outcome. A cornerstone of rehabilitation is respiratory physiotherapy with inspiratory muscle training to enhance pulmonary function. Prehabilitation is the process of enhancing functional capacity before surgery in order to compensate for the stress of surgery and postoperative recovery. There is growing interest in deploying pre-habilitation interventions prior to surgery.

The aim of this study is to assess the impact of preoperative inspiratory muscle training on postoperative overall morbidity. The question is, whether inspiratory muscle training prior to elective abdominal surgery reduces the number of postoperative complications and their severity grade.

INSPIRA is a prospective randomized-controlled single-center trial, non-blinded The aim of this study is to assess the impact of preoperative inspiratory muscle training on postoperative overall morbidity. The question is, whether inspiratory muscle training prior to elective abdominal surgery reduces the number of post-operative complications and their severity grade.

Furthermore, the impact of preoperative inspiratory muscle training on postoperative physiotherapeutic performance as surrogate of convalescence is assessed, too.

Patients will be instructed by physiotherapists to perform inspiratory muscle training containing of 30 breaths twice a day for 14-18 days before surgery using Power®Breathe KHP2.

Primary outcome is Comprehensive Complication Index (CCI) at 90 days after surgery. The CCI expresses morbidity on a con-tinuous numeric scale from 0 (no complication) to 100 (death) by weighing all postoperative complications according to the Clavien-Dindo classification for their respective severity.

Eligibility Criteria:
Inclusion Criteria:

* Informed Consent as documented by signature (Appendix Patient Informed Consent Form)
* Planned abdominal surgery with planned duration \>2hours (disease localization: upper vs. lower gastro intestinal, HPB, hernia, others)
* Planned surgery at least two weeks after inclusion at outpatient clinic
* Male and female patient over 18 years

Exclusion Criteria:

* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, of the participant
* Known or suspected non-compliance, drug or alcohol abuse,
* Previous enrolment into the current study
* Participation in another study with inspiratory muscle training within 30 days preceding or during this study
Urinary Infection in Pregnant Women with Urinary Infection

Urine analysis and culture in patients with threatened preterm labour

UTI is an infection of the kidneys, bladder, or urethra. Infectious cystitis is the most common type of UTI, which is caused by a bacterial infection of the bladder. Lifetime incidence of UTIs is 50% to 60% in adult women.UTIs are among the most common conditions encountered in primary care, hospitals, and extended care facilities . Total direct costs of UTI treatment (without cultures) have been estimated at US $25.5 billion annually.Despite an exceptionally high prevalence of bacteriuria in the population, these infections rarely cause significant renal damage.Sexual intercourse is the strongest risk factor. Any lifetime sexual activity and any sexual activity during the past year are strongly associated with recurrent UTI. Even the relatively small amounts of spermicide coating condoms increases the risk of UTI. Post-menopausal absence of oestrogen is a risk factor for UTIs. Topical oestrogen reduces UTIs in post-menopausal women; Oestrogenisation of the vaginal mucosa promotes lactobacilli colonisation, which reduces the presence of uropathogens and thus the risk of UTIs and is not recommended over the use of topical oestrogen therapy. Urinary incontinence and oestrogen supplementation have also been associated with UTI in older women, although the reasons for this are incompletely understood. positive family history of UTIs is associated with a two- to fourfold increase in risk of recurrent UTI . Bacteriuria occurs in the presence of indwelling or intermittent catheters, and asymptomatic bacteriuria does not require treatment. Gestational and pregestational diabetes are considered a more predominant risk factor in older women.

Eligibility Criteria:
Inclusion Criteria:

* pregnant women with preterm labor

Exclusion Criteria:

* renal disease Intrauterine fetal death
EPI, a Missed Opportunity for Postpartum Family Planning Utilization

The global unmet need for postpartum family planning remains high, while immunization services are among the most widely utilized health services. Most women in the extended postpartum period want to delay or avoid future pregnancies but many are not using a modern contraceptive method. Establishing systematic screening, counseling, and referral systems from different contact points particularly from infant immunization units may improve family planning access and uptake in the extended postpartum period. Hence, this study is aimed to assess the effect of counseling for family planning at immunization units on postpartum contraceptive uptake during the extended postpartum period.

Background: The global unmet need for postpartum family planning remains high, while immunization services are among the most widely utilized health services. Most women in the extended postpartum period want to delay or avoid future pregnancies but many are not using a modern contraceptive method. Establishing systematic screening, counseling, and referral systems from different contact points particularly from Expanded Program for Immunization (EPI) units may improve family planning access and uptake in the extended perinatal period.

Therefore, this study is proposed to assess the effect of counseling for family planning at immunization units on postpartum contraceptive uptake during the extended postpartum period.

To do this, a before-and-after type of quasi-experimental study will be conducted in purposively selected health centers in Sidama, South Ethiopia. All mothers coming to the selected health centers for infant immunization services will be screened for, counseled, and referred for family planning. A structured interviewer-administered questionnaire will be used to collect quantitative data from a total of 1474 randomly selected women coming to purposively selected health centers before and after the intervention. Bivariate and multivariable logistic regression analysis adjusting for possible confounding variables will be computed.

Eligibility Criteria:
Inclusion Criteria:

* all women visiting the selected health facilities at least two times during the pre-intervention period will be included

Exclusion Criteria:

* No exclussion critera
Hormonal Stimulation of Spermatogenesis

Urologists and reproductive specialists are often challenged when facing patients with severe male infertility scenarios. In particular, the treatment of men with NOA demands a deeper insight. In such cases, .

The hormonal stimulation of spermatogenesis is still being explored. Thus, there is still little knowledge regarding the type of patient who might benefit from medical treatment, the optimal medication,

the regimen, and the duration of treatment. In male infertility, the induction for treatment with follicle stimulating hormone (FSH) in the induction and maintenance of spermatogenesis in patient with hypogonadotopic hypogonaism. As these patients are normally azoospermic without gonadotropin stimulation and during testosterone therapy

The presence of high numbers of progressively motile and normally formed sperms in the ejaculate during exogenous gonadotropin therapy might result in the desired clinical pregnancy for many infertile couples on an experimental basis and in some places already in clinical routine. FSH preparation are also used for treatment of normogonadotopic infertile men with idiopathic impairment of spermatogemesis.

Pulstile GnRH or exogenous gonadotropins are usually used to induce spermatogenesis and promote testicular enlargement .The regimen for gonadotropin replacement includes an initial use of human chorionic gonadotropin (HCG) for 6 to 12 months and then addition of FSH or human menopausal gonadotropins (HMG) until pregnancy

Eligibility Criteria:
Inclusion Criteria:

* Men with primary infertility due to non-obstructive azoospermia in two seminal analysis

Exclusion Criteria:

1. Patients with non-obstructive azoospermia with normal or low level of FSH.
2. Patients with serum testosterone lower than 3 nmol/L.
Physiological Pacing for AV Block to Prevent Pacemaker-induced Cardiomyopathy

The implantation of a pacemaker and conventional cardiac pacing from the right ventricle (apex or septum) is an effective and safe therapy for the treatment of patients with atrioventricular block and bradycardia.

Pacemaker implantation and conventional cardiac stimulation from the right ventricle is an effective and safe therapy for the treatment of patients with atrioventricular block and bradycardia. But it can cause worsening of heart function, with a significant drop in LV ejection fraction, known as pacemaker-induced cardiomyopathy (PICM).

Conduction system pacing (either by his or left bundle branch pacing) causes a physiological left ventricular activation through the normal conduction system thus correcting the electrical and mechanical asynchrony caused by conventional pacing. Conduction system pacing may prevent the appareance of PICM.

Clinical, electrocardiographic, echocardiographic follow-up will be performed for 1 year.

Eligibility Criteria:
Inclusion Criteria:

* The patient must be ≥ 18 years of age.
* The patient must indicate their acceptance to participate in the study by signing an informed consent document.
* Patients with EF\> 50% and indication for pacemaker implantation due to atrial-ventricular block according to current clinical guidelines.

Exclusion Criteria:

* Inability to understand and sign the informed consent.
* Patients with severe comorbidities and life expectancy \<1 year.
* Patients with severe cognitive impairment or other comorbidities resulting in dependence for basic activities of daily life.
* Patients who cannot come to our center to carry out the follow-up of the study.
Effect of Intracameral Phenylephrine/Ketorolac on Intraoperative Pain

To compare the effect of intraoperative intracameral Omidria (Phenylephrine and Ketorolac 1.0%/0.3%) verses 1% Lidocaine on pain reduction during and after cataract surgery.


Eligibility Criteria:
Inclusion Criteria:

* Individuals with a cataract in the surgical eye

Exclusion Criteria:

* Patients that have previously exhibited sensitivities to acetylsalicylic acid, phenylacetic acid derivative, and other nonsteroidal anti-inflammatory drugs (NSAIDs)
* Those with a past medical history of asthma
* Those systemically using opioids or nonsteroidal anti-inflammatory drugs
* Those prescribed additional topical mydriatics, topical steroids, pilocarpine, or prostaglandins in the week preceding surgery
* Those with a history of alpha-1-adrenergic antagonist use
* Those with excisional, intraocular surgery in the planned surgical eye in the preceding year
* Those with a history of iris damage
* Those requiring iris expanding device or those with an acute or chronic uncontrolled eye condition, or those unable to effectively remember surgery or complete the post-operative assessment.
* Additionally, individuals less than 21 will be excluded.