cyrilzakka/clinical-trials huggingface dataset:
Comparison Between Different Horizontal Ridge Augmentation Techniques

Sixteen patients were selected from the Outpatient Clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University for replacement of missed single tooth / teeth in posterior atrophic mandible by dental implant.

Patients' grouping:

Patients were divided randomly into two equal uniform groups as follow:

Group I:

Eight implants were placed in patients of missing single tooth / teeth in posterior mandible with subsequent horizontal ridge augmentation by decompression technique.

Group II:

Eight implants were placed in patients of missing single tooth / teeth in posterior mandible with subsequent horizontal ridge augmentation by ridge splitting technique using piezosurgery.

All patients were evaluated clinically and radiographically at regular time interval immediately, 6 and 12 months after surgery.


Eligibility Criteria:
Inclusion Criteria:

* Patient's cooperation, motivation and good oral hygiene.
* Patient medically free from systemic diseases that absolutely contraindicate implant surgery.
* Moderately atrophic posterior mandible (horizontal alveolar dimension is not more than 4 mm at the crest), with minimum 10 mm vertical height.
* Patients prepared to comply with the follow-up and maintenance programme.
* Free from history of bruxism / parafunctional habits.

Exclusion Criteria:

* Patients with local pathological disease such as cyst, tumor at the planned surgical site.
* Pregnant patients.
* Heavy smoker patients.
Determination of Utility of Intergluteal Cleft as Landmark for Neuraxial Midline in Obstetrics

Our aim is to investigate whether a novel landmark, the groove between the buttocks or the intergluteal cleft, can facilitate the identification of the neuraxial midline in obstetric patients when compared to ultrasound as the reference standard for the determination of this midline

Determine if the intergluteal cleft, when compared to ultrasound as the reference standard, can be used to identify the neuraxial midline in obstetric patients

Difference in horizontal distance between the vertical lines of the intergluteal cleft and the neuraxial midline, the latter measured with ultrasound

Eligibility Criteria:
Inclusion criteria

* Female
* 18 years of age or older
* Gestation of 37 weeks or above

Exclusion criteria

* Acute or chronic confusional state
* Allergy to ultrasound gel
* Positive for COVID-19 and/or presence of symptoms consistent with SARS-Cov-2, such as anosmia, cough or fever
* History of previous surgery to the spine
* Scoliosis
* Unable to speak and/or understand English
Global Postural Reeducation Versus Neck Stabilization Training on Text Neck Syndrome.

The study will be randomized control trial. The study will be conducted in Iqbal Mehmooda Trust Hospital. Group A will be treated with global postural reeducation. Group B will be treated with neck stabilization training. Non probability consecutive sampling technique will be used. Patient below 20-40 years, participants who use smart phones for 8 hours per day(guidelines), angle of forward head pasture above 15, screening picture tool.

Neurological defects, trauma, tumor, shoulder injury, cervical disc disease. REBA questionnaire, NDI, Goniometry, NPRS will be used as a tool. The global postural reeducation will be applied on group A while neck stabilization training will be applied on group B. The aim of this study will be to compare the effects of of global postural reeducation and neck stabilization training on text neck syndrome.

''Text neck syndrome'' describes the neck pain and looking down at the smart gadgets repeatedly and for prolonged duration that leads to damage of various structures. The cervical spine consists of bundles of nerves, bones, joints and muscles. If nerves are compressed then pain can radiate to shoulder, arm and hand. 79% of the population between the age of 18-44 use their cell phones almost all the time except only 2 hours of their walking time without the usage of their cell phones. The forward head posture/Turtle neck posture causes strain on the muscles, ligaments and joints that leads to compression of nerves and it causes tingling and numbness in the hands. The usage of smart gadgets for prolonged duration has negative impact on our anxiety and depression. Excessive use of smart phones leads to postural problems like forward neck posture, slouched posture or rounded shoulders.

Eligibility Criteria:
Inclusion Criteria:

* Patient below 20-40 years
* Participants who use smart phones for 8 hours per day(guidelines)
* Angle of forward head posture above 15
* Screening picture tool

Exclusion Criteria:

* Neurological defects
* Trauma
* Tumor
* Shoulder injury
* Cervical disc disease
Clinical Trial of the TQB2930 Injection in Patients With Advanced Cancers

TQB2930 is an anti-HER2 (Human Epidermal Growth Factor Receptor 2) bispecific antibody that can simultaneously bind two epitopes of HER2, leading to a dual HER2 signal blockage. This is a phase I study to evaluate the safety, tolerability and effectiveness of TQB2930 injection in subjects with advanced malignancies.


Eligibility Criteria:
Inclusion Criteria:

* 1 Evidence of a personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study;
* 2 Male or female patient 18 to 75 years of age, an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1, and life expectancy ≥12 weeks;
* 3 Histologically or cytologically confirmed, locally advanced tumors, Priority will be given to subjects with HER2 positive solid tumor;
* 4 Malignant tumor that failed from standard treatment or had no standard treatment;
* 5 According to the RECIST 1.1 standard, patient with at least one evaluable lesion;
* 6 The main organs function well;
* 7 Male or female patient had no plans to become pregnant and voluntarily took effective contraceptive measures from agree with the study to at least 6 months after the last dose of study drug.

Exclusion Criteria:

* 1 Concurrent secondary malignancy. or other malignancy with no evidence of disease for more than 3 years;
* 2 History of uncontrolled intercurrent illness;
* 3 Major surgical procedure, radiotherapy, chemotherapy, or immunotherapy within 4 weeks prior to first dose;
* 4 Patients with known symptomatic brain metastases;
* 5 Receiving any other investigational agent within 4 weeks before first dose;
* 6 Unstable or serious concurrent medical conditions, as assessed by the Investigators, that would substantially increase the risk-benefit ratio of participating in the study.
Systems of Support Study for Childhood Depression

This study is designed to compare two treatments for depression in pre-adolescent (7-13 year old) children. A family-focused treatment will be compared to an individual child-focused treatment in this 14-week intervention.

Childhood-onset depression is an impairing and often recurrent and persistent disorder that impacts current and later development resulting in high personal, social, and economic costs. Despite the costs of early-onset depression, the emphasis in current practice parameters on an initial course of psychosocial treatment, and extensive research on adolescent depression, we currently lack randomized controlled trials evaluating psychosocial treatments for children with depressive disorders.

The present proposal aims to address this gap in knowledge regarding optimal psychosocial treatment strategies for children suffering from depressive disorders. We propose a 2-site randomized controlled trial to evaluate the efficacy of Family Focused Treatment (FFT), as compared to an individual client-centered psychotherapy (IP) modeled after "usual" community care. FFT adopts an interpersonal model for understanding how depressive symptoms are maintained, emphasizes developing family skills/strategies for altering interpersonal processes, and works on building a family environment that supports recovery and enhances stress resistance and resilience. This approach may be particularly appropriate to the developmental needs of depressed children, given their dependence on parents, the potential of FFT to address the needs of multiple family members, and our data supporting benefits on depression, functioning, and other co-occurring symptoms.

The proposed project will enroll 140 children (ages 8-12) with depressive disorders. Children will be randomly assigned to receive a 14-week trial of either FFT or IP. At study entry, immediately post-treatment, and at a 9-month post-treatment follow-up all participants will undergo intensive evaluation of clinical state and psychosocial and family functioning.

Eligibility Criteria:
Inclusion Criteria:

* current Depressive Disorder
* ages 7-13 years
* living with at least one biological parent willing to participate

Exclusion Criteria:

* thought disturbance
* severe conduct disorders
* unstable on antidepressant medications
* continuation in current non-study treatment
* non-English speaking
Wide-awake Local Anesthesia and no Tourniquet (WALANT) in Plastic Surgery

Wide-awake local anesthesia no tourniquet (WALANT) was proposed and performed in hand operations.

Aim of this study is to present the use of WALANT in operations performed on the upper and lower limbs, evaluate its efficacy in terms of feasibility, total operation time, total operating room time, bleeding, patient discomfort and satisfaction and control for potential drawbacks. The hypothesis is that WALANT is a viable option in common operations performed by plastic surgeons on the upper and lower limbs.

Wide-awake local anesthesia no tourniquet (WALANT) was proposed and performed in hand operations. Little has been studied, regarding its indications and efficacy in general plastic surgery operations.

Aim of this study is to present the use of WALANT in operations performed on the upper and lower limbs, evaluate its efficacy in terms of feasibility, total operation time, total operating room time, bleeding, patient discomfort and satisfaction and control for potential drawbacks. The hypothesis is that WALANT is a viable option in common operations performed by plastic surgeons on the upper and lower limbs.

A prospective study will be conducted comparing the use of WALANT in operations performed on the upper and lower limbs to the traditional use of tourniquet with general or regional anesthesia.

Eligibility Criteria:
Inclusion Criteria:

* upper or lower limb operation
* indication for flap or skin grafting
* operated by the principal investigator

Exclusion Criteria:

* other concomitant operations performed
* known allergy to any of the ingredients of local anesthesia mixture
Collection, Evaluation and Assessment of Adverse Drug Reactions on the Oncology Ward

The proposed cohort study collected within a 5-month observation period adverse drug reaction (Adverse Drug Events - ADE) in patients at the Department of Oncology at the University of Zurich. ADE have been recorded using prospective monitoring and assessed using standardized algorithms regarding causality and severity. Data sources included information from the medical records, laboratory values and internal rounds. Additional information has been collected using a standardized patient questionnaire.

The primary endpoints of this study are to determine the frequency of ADE, the comparison of the quality of data sources and collection methods for the detection of ADE in regard to patient characteristics, size, number of medications, the category of ADE, severity, causation, diagnosis, hospitalization, cause of hospitalization and medication cause. Secondary endpoint is the assessment of the ADE causality, severity and predictability.


Eligibility Criteria:
Inclusion criteria:

* German-speaking patients,
* At least 18 years old.

Exclusion criteria:

* Patients who could not give her consent, or have given, and any minor patient.
Observational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy

Pre-eclampsia and intra uterine growth restriction (IUGR) represent major complications for pregnant women, with a high related maternal and fetal morbidity and mortality. It is now widely admitted that these pathologies, which can concern up to 7% of pregnancies, are in relation with hypo-perfusion of the placenta because of an early deficient trophoblast invasion and uterine vascular remodelling.Advances in ultrasound imaging now permit non invasive 3D volume and Doppler signal quantification using automatic acquisitions.Quantitative comparison of volumes and Doppler parameters between control pregnancies and IUGR ought to confirm the theory of UTERO-placental hypo-perfusion. This technique might allow an earlier prediction for IUGR. The aim of this study is to evaluate the interest of 3D Doppler quantification as a new screening tool for pre eclampsia and IUGR.

One hundred high risk women and 70 low risk women will be included. Inclusion criteria for the high risk group are: personal history of pre eclampsia and/or IUGR in a previous pregnancy, diabetes, auto-immune syndrome such as LUPUS, hypertension, renal insufficiency, and anti-phospholipid syndrome.Patients (over 18 years old) will be included between 11 and 14(+6days) WG. Only singletons pregnancies will be included.3D Doppler standardized acquisitions of the UTERO-placental unit will be performed at each usual ultrasound examination of the pregnancy.Data will be analysed after delivery, in terms of quantified Doppler values, comparing two groups: pregnancies with pre eclampsia / IUGR (group with pathology) and normal pregnancies (control group).This is an observational study.

Eligibility Criteria:
Inclusion Criteria:

* Age eligible for study up to 18 years
* Gestational age between 11 to 14 weeks for the first visit (first-trimester pregnancy).-Singleton pregnancy
* Consent to participate in the study
* Patients affiliated to social security

Group 1:

-Personal History of:

* Preeclampsia during a previous pregnancy: Blood pressure more than 140 mmHg systolic and/or 90 mmHg diastolic + proteinuria
* Diabetes
* IUGR during a previous pregnancy (birth weight \< 10th centile)
* Hypertension
* Renal insufficiency
* Autoimmune Disease : Antiphospholipid syndrome

Group 2:Absence of all the Group 1 affiliation criteria.

Exclusion Criteria:

* Participating in the study
* Unability to understand the study
* Set back of patient consent.
China Red Eye Study on Allergic Conjunctivitis

This study is the first multi-center cross-sectional study on the diagnosis and misdiagnosis of allergic conjunctivitis in the ophthalmology clinic in China. It provides a clinical basis for the standardized diagnosis and treatment of allergic eye diseases.

Allergic conjunctivitis is a common disease in ophthalmology. The European Allergy Association, Japan, the United States and other countries have clear diagnostic criteria or guidelines for the definition and diagnosis of allergic diseases and allergic conjunctivitis. However, China is currently lacking related guidelines. Allergic conjunctivitis has some of the same symptoms and signs as other infections/non-infectious conjunctival inflammation. When the symptoms and signs are atypical, it is prone to missed diagnosis and misdiagnosis, resulting in prolonged disease duration, drug abuse and waste of medical resources.

The current abuse of antibiotics is considered to be a huge problem in the treatment of ocular surface diseases. A study in our country believes that the rate of misdiagnosis of dry eye is as high as 66.2%, and most of them are misdiagnosed as chronic conjunctivitis, resulting in frequent using a variety of antibiotic eye drops. At present, the misdiagnosis of allergic conjunctivitis and the abuse of antibiotics caused by misdiagnosis in China are still unclear, therefore clinical research is urgently needed. We intend to use this study to understand the status of diagnosis and treatment of allergic conjunctivitis in China, and provide clinical evidence for the standard diagnosis and treatment of allergic eye diseases.

Eligibility Criteria:
Inclusion Criteria:

* Patients whose clinical diagnosis is allergic conjunctivitis.

Exclusion Criteria:

* The investigator believes that there are any unsuitable reasons for participating in the trial.
Wellness of Osteopathic Medical Students Throughout Their Training (Well-COM)

The Well-COM Research Project addresses a critical gap in our understanding of the holistic health of medical students, over the entirety of the medical school experience. While the rigorous demands of medical education and its effects on the well-being of medical students are well-documented, there is a lack of long-term study assessing the mental, physical, and metabolic health of medical students from entry into medical school through their training and into residency. By collecting holistic health data from new first-year medical students, and over a minimum period of 10 years, the Well-COM project aims to provide invaluable insights into the changes in health and wellness experienced by medical students, thereby informing future interventions and support systems to promote overall health and resilience in medical school students.


Eligibility Criteria:
Inclusion Criteria:

* Medical student enrolled in SHSU college of osteopathic medicine.

Exclusion Criteria:

-
Economic Evaluation and Communication in Remote Monitoring of People With Pacemakers

The purpose of this research is to estimate the outcomes in health and cost of the follow-up of patients with pacemakers.

The initial hypothesize of this study is that remote monitoring of pacemaker will show a best relation of outcomes in costs and effectiveness than the conventional follow-up in hospital.

Cardiovascular Diseases are a major cause of global morbidity and mortality, being responsible according to the World Health Organization of the 30% of overall mortality.

Since 2001 that the first pacemaker of remote monitoring was implanted in Europe, more than 300,000 pacemaker have been implanted around the world. Despite this sharp expansion, the scientific evidence on economic evaluations of pacemaker with remote monitoring is very limited, and in our knowledge, studies including informal costs have not been conducted.

In the field of cardiology, telemedicine allows consultations with patients through monitoring systems and remote communication analyzing the ongoing heart rates of people with pacemakers, implantable cardioverter defibrillators, cardiac resynchronization therapy and subcutaneous Holter. The use of remote monitoring may save time and efforts to both healthcare professionals and patients, including their informal caregivers, reducing the number of follow up visits to the hospital and reducing the associated costs with patient follow-up, which will help to improve sustainability of healthcare services.

During the 06 months of study, the patients with implant of pacemakers of both groups will be assessed of the same parameters, in 3 different moments (pre-implant and months 1, and 6 post-implantation).

Pacemakers that are going to be used in the project:

1. Remote monitoring group: Biotronik Estella SR-T and DR-T \& Biotronik Evia SR-T and DR-T.
2. Hospital monitoring group: St Jude Medical Endurity SR and DR \& Sorin Reply 200 SR and DR.

The study will estimate: 1) The Clinical features of the patients. 2) The effectiveness through of administration of Health-Related Quality of Life questionnaires and 3) Finally, hospital and informal costs of patients with pacemakers will be estimated by the researches.

Eligibility Criteria:
Inclusion Criteria:

* Be 18 years of age
* Have a pacemaker implanted
* Understand and be able to properly perform self-monitoring at home

Exclusion Criteria:

* Be participating in another study
* Refuse to participate in the study
* Have implanted a different cardiac device to the pacemaker
The Correlation Between Degeneration of Paraspinal Muscle and Outcome of Patients With Lumbar Spinal Stenosis

The photographical and functional parameters of paravertebral muscle in patients with lumbar spinal stenosis will be measured to investigate the correlation between paravertebral muscle degeneration and symptoms and prognosis of patients.By measuring the parameters of paravertebral muscle with normal people, the differences between the patients and normal people will be compared to establish an appropriate paravertebral muscle evaluation method.

It is a prospective observational study. This study will recruit 200 patients with lumbar spinal stenosis who will undertake posterior lumbar decompression and fusion surgery in our hospital.They all take preoperative lumbar mri examination and waist and back muscle strength test as well as recording their preoperative visual analogue scale,oswestry disability index, lumbar stiffness disability index score.All patients will receive a follow-up lasting for 1 year,and we will record patients outcomes,such as visual analogue scale,oswestry disability index and lumbar stiffness disability index score at each follow-up time. At the same time,we will recruit 100 healthy subjects without lumbar diseases or chronic lumbar pain. The difference of their age with patients was less than 5 years. Meanwhile, lumbar dorsal muscle strength test and lumbar mri examination were conducted, and visual analogue scale as well as oswestry disability index and lumbar stiffness disability index score was recorded in healthy subjects.

Eligibility Criteria:
Inclusion Criteria:

* patients with lumbar spinal stenosis
* age\>45 years old
* without other spinal disease
* without history of former spinal surgery

Exclusion Criteria:

* With neuromuscular diseases
* With hip joint or knee joint disease
* Acute or severe chronic back pain of spinal stenosis that could interfere with the evaluation of endurance
* Other serious diseases impacting the evaluation of endurance