cyrilzakka/clinical-trials huggingface dataset:
Maitland Mobilization Versus Mulligan Mobilization in Sub-Acute and Chronic Non-Specific Neck Pain

This study investigate the short term effect of Maitland in comparison to Mulligan mobilization with sub-acute and chronic non specific neck pain to improve neck pain, pain pressure threshold, rang of motion, joint position sense, disability, and to evaluate the interaction with psychological factors.

Study design: experimental study

44 patients with sub-acute or chronic neck pain will be randomized into Maitland group: 22 patients receive central postro anterior or unilateral postero anterior. Mulligan group: 22 patients receive sustain natural apophyseal glides. The treatment will be 2 times /week for three weeks. Measurement will be taken pre intervention and after three weeks for neck pain, pain pressure threshold, range of motion, joint position sense, and disability using a numeric pain rating scale, pain pressure threshold test, cervical range of motion device, and neck disability index, depression, anxiety, fear avoidance believe and pain catestrophizing respectively.

Eligibility Criteria:
Inclusion Criteria:

* • Patients aged between 20 to 50 years.

  * Neck pain more than one week without radicular symptoms.
  * Pain on posterior neck from superior nuchal line to first thoracic vertebra.

Exclusion Criteria:

* • Patient contraindicate to mobilization (pregnancy, whiplash injury, tumor, fracture, metabolic diseases, rheumatoid arthritis, osteoporosis and resting blood pressure higher than 140/90 mmHg).

  * Cervical radiculopathy.
  * Fibromyalgia pain syndrome.
  * Previous neck surgery.
  * Neck pain associate with vertigo caused by vertebrobasilar insufficiency or chronic headache.
  * Patient received physical therapy treatment in the previous three months.
  * Psychiatric disorders.
  * Vestibular system deficits.
INVSENSOR00027 Clinical Performance Study

This study assesses the investigational sensor's (INVSENSOR00027) performance for detection of subjects' position and posture in bed, along with heart rate and respiratory rate.


Eligibility Criteria:
Inclusion Criteria:

* 18 to 80 years old
* Physical status of ASA I or II
* Subjects must be able to read and communicate in English
* Has signed all necessary related documents, e.g. written informed consent, volunteer payment form, confidentiality agreement
* Has completed Health Assessment Questionnaire and passed health assessment screening

Exclusion Criteria:

* Subject has any medical condition which in the judgment of the investigator, renders them inappropriate for participation in this study
* Inability to tolerate sitting still or minimal movement for at least 30 minutes
* Nursing female volunteers
* Excluded at the Principal Investigator's discretion
* Refusal to take the pregnancy test (for female subjects)
* Positive pregnancy test for female subjects of child bearing potential. This is done for the safety of this population.
* Refusal to shave hair (neck, chest) off areas where sensors will be applied (male subjects)
The Effect of Diet Composition on Performance, Expenditure, Blood Lipids, and Appetite Hormones in Highly Trained Cyclists

This study employs a crossover design to evaluate the effect of two different diets (high carbohydrate vs. ketogenic) and corresponding test meals on endurance exercise performance, energy expenditure including resting metabolic rate and thermic effect of food, postprandial responses of blood lipids, glucose and appetite hormones, and cognitive function and mood states.

Traditionally, a high carbohydrate diet is recommended for elite endurance athletes and sub-elite, highly trained recreational athletes competing in endurance events. However, recently the ketogenic diet (extremely low carbohydrate content) has become popular in these populations. The effect on endurance exercise performance, energy expenditure, postprandial blood profiles, and cognitive function and mood states requires further investigation.

In this study, highly trained recreational cyclists and triathletes will adhere to each diet (high-carbohydrate and ketogenic) for 14 days in a crossover design. Experimental trials at baseline and after each diet will evaluate endurance cycling performance (time trial), resting energy expenditure, the thermic effect of food of test meals corresponding in composition to each diet, postprandial responses of blood lipids, glucose and appetite hormones, and cognitive function and mood states.

Eligibility Criteria:
Inclusion Criteria:

* \>100-150km of cycling per week
* VO2max \> 80th percentile for sex and age (adjusted for cycle ergometry)
* apparently healthy

Exclusion Criteria:

* weight loss supplements/medications/diet
* extreme dietary patterns (e.g. extremely high or low carbohydrate)
* nicotine use
* heavy alcohol use (\>7 drinks/week female; \>14 drinks/week male)
* food allergies
* diabetes
* heart disease
* stroke
* liver/kidney/thyroid disease
* anemia
* eating disorders
* uncontrolled hypertension
* pulmonary/orthopedic/musculoskeletal problems that prevent exercise
* surgery that affects swallowing and digestion
* claustrophobia
Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy

Macrohemodynamic impact of fluid removal with net ultrafiltration in patients with continuous renal replacement therapy. A monocentric ancillary study of the EarlyDry randomized controlled trial.


Eligibility Criteria:
Inclusion Criteria:

* Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days,
* At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or vasopressors administration\>12 hours),
* Cumulative UF net less than 1000ml before inclusion,
* Norepinephrine \< 0,5 µg/kg/min,
* Absence of hypoperfusion signs,
* Fluid overload defined as follows: fluid overload \> 5% of base weight (based on cumulative fluid balance or a weight gain) and/or peripheral edema (AKIKI edema scale \> 2).

Exclusion Criteria:

* Chronic renal failure hemodialyzed before admission to the ICU,
* Mechanical circulatory support (ECMO, LVAD),
* Pregnant, child -bearing age or lactating women,
* Stroke less than 30 days,
* Intestinal ischemia less than 7 days documented non-operated,
* Interventional study participation or exclusion period on going,
* Guardianship, curatorship or safeguard of justice,
* Absence of signature of free and informed consent by the patient and/or relative,
* Patients not affiliated to a social security scheme or beneficiaries of a similar scheme
* Absence of transpulmonary thermodilution monitoring
Moderate Whole Body Hyperthermia for Patients Undergoing Re-irradiation for Head and Neck Cancer -Influence on the Tumor Microenvironment

The aim of the study is to determine the feasibility and efficacy of moderate weekly whole Body hyperthermia Treatment during radiochemotherapy for pre-irradiated locally or regionally recurrent head and neck squamous cell carcinomas.

The Primary aim of the study is feasibility, defined as 80% of patients completing at least four applications of hyperthermia.

Secondary endpoints include an increase of Tumor Perfusion by the use of hyperthermia, measured by magnetic resonance Imaging during week two of Treatment and reduction of Tumor hypoxia, measured by hypoxia specific Positron emission tomography.

Previously irradiated patients with loco/ loco-regional recurrent head and neck squamous cell carcinomas usually undergo re-irradiation. However prognosis of these patients is unfavourable, especially for non-human papilloma virus associated cancers. Moderate whole body hyperthermia will be performed by water-filtered IR-A-radiation using a Heckel-HT3000 device.

Preclinical data have indicated that moderate whole body hyperthermia decreases intratumoral interstitial fluid pressure and leads to increased perfusion of the tumor. The study investigates if this holds also true in patients and leads to a marked decrease of tumor hypoxia, measured by 18F-Fluoromisonidazole PET.

The Primary aim of the study is feasibility, defined as 80% of patients completing at least four applications of hyperthermia.

Secondary endpoints include an increase of Tumor Perfusion by the use of hyperthermia, measured by magnetic resonance Imaging during week two of Treatment and reduction of Tumor hypoxia, measured by hypoxia specific Positron emission tomography.

Eligibility Criteria:
Inclusion Criteria:

* patients with unresectable local, regional or loco-regional recurrent non HPV-associated squamous cell head and neck cancer with prior high-dose radiotherapy of the head and neck region
* time interval of 6 months to 5 years after completion of last radiotherapy of the head and neck region
* Completed staging examinations, preferentially 18f-fluorodeoxyglucose (FDG) PET of the whole body
* general health condition according to ECOG status of 0,1 or 2
* age between 18 and 75 years
* written informed consent

Exclusion Criteria:

* HPV associated primary tumor or recurrent tumor
* recurrence more than 5 years after end of previous radiotherapy
* Any medical circumstances impeding the application of radiotherapy, concomitant chemotherapy or whole body hyperthermia
Effectiveness of Urethral Stent Irrigation in Preventing Surgical Site Infections in Adolescents with Hypospadias

This prospective, cluster-randomized, crossover, two-arm controlled clinical trial aims to determine whether urethral stent tube irrigation, combined with urinary catheter drainage, prevents postoperative wound infections compared to urinary catheter drainage alone in adolescents with hypospadias.

Hypospadias is one of the most common genital developmental malformations in pediatric patients, with a prevalence of approximately 0.5%. The primary manifestations of hypospadias include an ectopic urethral opening, penile recurvature, and abnormal distribution of the prepuce. Currently, urethroplasty is the only treatment for hypospadias, with surgery recommended within the first three years of life. However, due to economic, cultural, and social factors, many children miss the optimal age for surgery and require initial or re-repair surgery during puberty. Additionally, some children who underwent hypospadias repair before puberty develop penile recurvature and other complications during adolescence, necessitating reoperation. Physiological changes during puberty, such as penile growth, pubic hair development, increased skin appendages, secretions, and frequency of erections, increase the risk of wound infection and poor healing post-surgery. To address these issues, we placed a stent in the reconstructed urethra of adolescents with hypospadias and performed urethral irrigation postoperatively.

Eligibility Criteria:
Inclusion Criteria:

1. Patients diagnosed with hypospadias and in Tanner stages II-V at the Department of Urology, Affiliated Children's Hospital of Chongqing Medical University.
2. Patients and their guardians have been informed about the nature of the study, understand the protocol, can ensure compliance, and have signed an informed consent form.

Exclusion Criteria:

1. Patients undergoing meatal advancement and glanuloplasty (MAGPI) only.
2. Patients undergoing penile recurvature correction only.
3. Patients undergoing urethrostomy only.
4. Patients with contraindications to the procedure, such as severe cardiac disease, systemic or localized infection, thrombocytopenia, coagulation disorders, congenital immunodeficiencies, or uncontrolled diabetes mellitus.
5. Patients already enrolled in or during the follow-up of other clinical studies. Patients who do not wish to participate in this study or demonstrate poor compliance with follow-up requirements.
Frequency of Methods of Local Invasion of Pancreatic Adenocarcinoma

Pancreatic cancer often spreads through local invasion into local structures, including fat, blood vessels, nerves, and nearby organs (stomach, duodenum, spleen, bile duct). Local microscopic invasion is associated with recurrence of pancreatic cancer after pancreatic resection, such that even if the original cancer is surgically removed, microscopic areas of cancer often remain. Data on the patterns of local invasion by pancreatic cancer have not been published. In this study, The investigators hope to investigate the frequency of the various methods of local invasion of pancreatic adenocarcinoma. This would help the investigators better understand how pancreatic cancer spreads, and determine what cancers are not resectable.

Pancreatic cancer is the eighth most common malignancy, and the fifth leading cause of cancer-related death, in the United States. Unfortunately, patients often present late in the course of the disease. Accordingly, the 1- year survival rate is approximately 20%, and the 5-year survival rate is less than 4%. Even in patients with local disease who are surgical candidates, survival at five years remains only 10-25%. Staging for pancreatic adenocarcinoma typically utilizes the TNM classification, where "T" represents tumor size, "N" represents regional lymph node metastasis, and "M" represents distant metastasis. This type of staging can usually only be done after operative resection. Unfortunately, up to 25% of patients are found to be unresectable at the time of surgical exploration. This is most often due to local invasion or metastatic disease. Local microscopic invasion is associated with recurrence of pancreatic cancer after pancreatic resection. Comprehensive data on the patterns of local invasion by pancreatic cancer have not been published. The investigators believe that it would be beneficial to investigate the frequency of the various methods of local invasion of pancreatic adenocarcinoma. A clearer understanding of the natural history of local invasion could potentially lead to a better determination of what constitutes unresectability.

Eligibility Criteria:
Inclusion Criteria:

* Tissue confirmed diagnosis of pancreatic adenocarcinoma.
* Underwent surgical resection for adenocarcinoma at the Columbia University Medical Center between 2001-2009.

Exclusion Criteria:

* Did not undergo surgery.
Adenoid Cystic Carcinoma and Carbon Ion Only Irradiation

Adenoid cystic tumors are rare tumors of the head and neck region. Despite their slow growth, re-irradiation is often necessary due to the high metastatic risk. Patients are usually irradiated with photons or, as here at the Heidelberg University Hospital, with a combination of carbon ions and photons. So far, there is no data from Europe available for the sole irradiation with carbon ions. The present ACCO (Adenoid Cystic Carcinoma and Carbon ion Only irradiation) study, a prospective, open-label, phase II, single-arm, investigator-initiated study, will therefore investigate the sole radiotherapy of carbon ions in this tumor entity. Irradiation is applied - significantly shorter than the combination therapy - in about 4 weeks (22 fractions); patients are followed up for further 5 years after the start of therapy. Carbon ions alone are expected to increase local tumor control rates from 60% to 70% after 5 years (primary objective criterion of this study). In order to reject the null hypothesis with a power of 80% and a significance level of 5%, 175 patients are included (including a drop-out rate of 15%). Secondary objective criteria are progression-free survival, overall survival, acute and late toxicity, and quality of life.


Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed adenoid cystic carcinoma in the head and neck area
* Indication for irradiation:
* non-operable or
* R1/R2 resected or
* perineural sheat invasion (Pn+) or
* pT3/pT4
* Informed consent
* KI \> 60% or ECOG 0/1 (minimum: self-sufficiency, normal activity or work not possible)
* Age 18-80 years

Exclusion Criteria:

* rejection of the study by the patient
* Patient is not able to consent
* Stage IV (distant metastases), except lung metastases \< 1cm
* lymph node involvement (clinical or pathological)
* Previous radiotherapy in the head and neck area
* Active medical implants for which there is no ion radiation authorization at the time of treatment (e.g., cardiac pacemaker, defibrillator, ...)
* Contraindication to MR imaging
* Simultaneous participation in another clinical study that could influence the outcome of this study or the other study
* Pregnancy
Impact of Perioperative Anesthetic Management on Renal Cancer Progression.

The relationship between perioperative drugs, including preoperative medications, anesthetics, and analgesics, and postoperative outcomes in cancer patients is a complex and evolving field of study. Understanding how those medications might impact outcomes such as pain, acute kidney injury, and recurrence is crucial for optimizing perioperative care in renal cancer patients.

This retrospective study will investigate the association of perioperative drugs on short and long-term postoperative outcomes in patients undergoing kidney surgeries for renal cell carcinoma.

Eligibility Criteria:
Inclusion Criteria:

1. Adult Participants (18 years of age or older)
2. Participants having radical or partial nephrectomies with curative intent.

Exclusion Criteria:

1. Patients with distant metastatic disease and those with multiple (more than 1) primary tumors at the time of the nephrectomy
2. Biopsies
3. Participants who had radiofrequency or microwave ablations.
Use of Glidesheath Slender to Reduce Radial Artery Occlusion Following 7 French Transradial Coronary Intervention

The objective of this study is to determine the rate of early radial artery occlusion following 7-French(7-Fr) transradial coronary intervention using a new Terumo (Tokyo, Japan) Glidesheath Slender, in comparison with the currently used 7-Fr radial sheath.

Based on previously reported studies the rates of radial artery occlusion using a standard 7-Fr sheath is around 12%, compared to the previous studies of the Glidesheath Slender (see reference in the citations), the rate of radial artery occlusion was reported less than 5%. To prove Slender sheaths are superior to traditional ones, the sample size was estimated according to this, the class I error (α) is set as 0.05 on both sides, and the test efficiency (β) is set as 80%, then at least 248 patients are needed in each group.

This study will be a prospective randomized, single-blinded (patient-blinded) study, comparing the rate of radial artery occlusion between the 7-Fr Glidesheath Slender (Terumo, Japan) and the standard 7-Fr radial sheath (cordis, USA) in patients undergoing complex transradial coronary intervention.

The study will enroll patients who will undergo elective complex percutaneous coronary intervention (PCI) via 7-Fr transradial approach at Fuwai Hospital National Center for Cardiovascular Diseases.

A baseline clinical vascular \& ultrasound assessment will be performed prior to the procedure to document patency of the radial artery.

Patients will be randomized in 1:1 fashion to either receive the 7-Fr Terumo Glidesheath Slender versus the currently used 7-Fr sheath.

The standard angiogram/ PCI will be performed as per usual practice. Following the PCI, clinical vascular assessment as well as an ultrasound will be performed prior to discharge.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing coronary PCI via 7-Fr transradial approach
* Informed consent
* the patency of radial artery confirmed by ultrasound

Exclusion Criteria:

* The abnormal of radial artery confirmed by ultrasound
* Previous failed radial access.
* Known bleeding disorder or hypercoagulable condition
* Cardiogenic shock
Peristomal Skin Complications and Quality of Life

This study is a single blind semi-experimental study.

Aim: To investigate the effect of standardized care on peristomal skin complications and quality of life in colorectal cancer patients undergoing ostomy surgery.

H1: Standard stoma care which is established evidence-based guides and complication algorithm, reduces peristomal skin complications in patients with colorectal cancer and an ostomy.

H2: Standard stoma care which is established evidence-based guides and complication algorithm, increases the quality of life in patients with colorectal cancer and an ostomy.

In order to ensure blindness in the study design, patients were not informed about which group they belonged to.

Patient with ostomy in the study group were trained in accordance with the Standard Stoma Care.

Patient with ostomy in the control group only skill and discharge training has been provided in accordance with the hospital procedure.

All patients were followed up at 2, 6, and 12 weeks. Peristomal complications were evaluated by the researcher with the Peristomal Skin Tool at the 2nd, 6th and 12th weeks. The patients were asked to fill the Stoma Quality of Life Scale in the 2nd, 6th and 12th weeks.

Eligibility Criteria:
Inclusion Criteria:

* undergoing colorectal surgery,
* permanent or temporary ileostomy or colostomy
* end or loop ileostomy or colostomy

Exclusion Criteria:

* individuals who have previously had stoma surgery,
* having two or more stoma,
* individuals with crohn's disease
* individuals who do not want to participate in the study
Effect of Kinesio Tape on Oral and Pharangeal Swallowing Phases in Children With Spastic Cerebral Palsy

The purpose of current study is to investigate the effect of kinesio tape in children with spastic cerebral palsy having oropharyngeal dysphagia

The study tageted rhe children with spastic cerebral palsy from both sexes will be selected from hospital of Tanta university

Inclusion criteria:

1. Age ranges from 2 to 7 years.
2. The degree of dysphagia ranges from 4 to 6 level according to functional oral intake scale (appendix II).
3. Diagnosed as spastic diplegia or quadriplegia.
4. Able to understand and follow instructions.

Exclusion criteria:

Children will be excluded if they have any of the following criteria:

1. Severe visual and auditory problems.
2. History of maxillary, head or neck surgical procedures.
3. Botulinum toxin treatment of upper esophageal sphincter dysfunction, esophageal dysphagia and/or gastroesophageal reflux disease during the previous six months.

Eligibility Criteria:
Inclusion Criteria:

1. Age ranges from 3 to 7 years.
2. The degree of dysphagia ranges from 4 to 6 level according to functional oral intake scale (appendix II).
3. Diagnosed as spastic diplegia or quadriplegia.
4. Able to understand and follow instructions.

Exclusion Criteria:

Children will be excluded if they have any of the following criteria:

1. Severe visual and auditory problems.
2. History of maxillary, head or neck surgical procedures.
3. Botulinum toxin treatment of upper esophageal sphincter dysfunction, esophageal dysphagia and/or gastroesophageal reflux disease during the previous six months.
Better Lifestyle Counseling for African American Women During Pregnancy

The purpose of this randomized controlled trial is to establish the effectiveness of a culturally targeted and individually tailored behavioral intervention to promote maternal glucose metabolism in African American women.

This is a randomized controlled parallel-group trial with two arms. Potential subjects will be identified from the OB Clinics at UI health systems, the University of Illinois at Chicago. After baseline assessments, the subjects will be randomized to the attention control arm (Birth-Prep) or BETTER intervention.

Eligibility Criteria:
Inclusion Criteria:

* African American pregnant woman.
* Women between 16 and 22 GWs.
* Overweight or obese - pregravid Body Mass Index \>25.0 kg/m2.
* Singleton gestation.
* Established prenatal care at The University of Illinois Hospital \& Health Sciences.
* System Obstetric (UIHHSS' OB) clinics. Able to understand, speak and write in English.

Exclusion Criteria:

* Multiple gestations.
* Night-shift work.
* Diagnosed sleep disorders.
* Known fetal chromosomal or anatomical abnormalities.
* Diagnosed mood disorders.
* Gestational diabetes in early pregnancy.
* Glycated Hemoglobin (HbA1c) ≥ 6.5%.
* Hypoglycemic medications.
* Stimulant medication or taking a sleeping aid.
* Active drug abuse/excessive alcohol intake.