cyrilzakka/clinical-trials huggingface dataset:
The Effectiveness of Assertive Community Treatment on Schizophrenic Patients

Assertive community treatment (ACT) is a community-based, patient-centered, and rehabilitation-oriented model based on multidisciplinary service teams. It has been proved to be suitable for the management of patients with severe mental disorder in the community. In this study, we aimed to investigate the effectiveness of ACT in an urban district of Shanghai with a larger sample size and a 24-month duration of follow up. We hypothesized that patients assigned into ACT would show better improvement in psychiatric symptoms and social function.

Assertive community treatment (ACT) is a community-based, patient-centered, and rehabilitation-oriented model based on multidisciplinary service teams. It has been proved to be suitable for the management of patients with severe mental disorder in the community. In this study, we aimed to investigate the effectiveness of ACT in an urban district of Shanghai with a larger sample size and a 24-month duration of follow up. We hypothesized that patients assigned into ACT would show better improvement in psychiatric symptoms and social function.The study protocol was approved by the Institutional Review Board in Shanghai Mental Health Center.

Aim of the study: 1.1 To explore the effectiveness of assertive community treatment in patients with schizophrenia. 1.2 The patients were followed up for 24 months to explore the duration of ACT.

Introduction of the study: Patients who previously diagnosed as schizophrenia according to International Classification of Diseases 10th Revision (ICD-10) in the psychiatric hospitals would receive basic public health service in the community. The selected schizophrenic patients were randomly assigned into intervention group and control group by a computer randomization algorithm. During the following 2 years, the control group received basic public health services in the community while the intervention group received ACT. Clinical assessments were conducted at baseline and every 6 months till the end of the 2-year study. A single-blind method was used, in which all the assessments were independently completed by trained psychiatrists who didn't know the grouping.The Positive and Negative Symptoms Scale (PANSS) and the Personal and Social Performance Scale (PSP) were measured at baseline and every 6 months during the study.

Eligibility Criteria:
Inclusion Criteria:

1. aged between 18 and 50 years old;
2. course of disease between 2 and 20 years;
3. living with family members who can function as their caregivers;
4. disease condition was stable and the total score of the Positive and Negative Symptoms Scale (PANSS) is less than 60.

Exclusion Criteria:

1. women during pregnancy;
2. having mental retardation or psychoactive substance-induced mental disorders;
3. having serious physical condition.
Assessment of Pelvic Floor Function in Elderly

The purpose of this study is to demonstrate the importance of functional assessment of the pelvic floor (AFA) in older women, as prognostic factor for Urinary Incontinence (UI).

Incontinence elderly assessment

Eligibility Criteria:
Inclusion Criteria:

* Elderly women
* Urinary incontinence

Exclusion Criteria:

* Cesarean surgery
D081AC00001 Food Interaction With Olaparib Capsule in Patients With Solid Tumours

This is a 2 part study for patients with solid tumours. The purpose of Part A is to measure the amount of olaparib or its breakdown products in the bloodstream for up to 72 hours after eating 3 different breakfasts (high calorie, regular and none). In Part B Patients can take olaparib capsules daily and study assessments will be recorded for 6 months (minimum). Treatment can continue for as long as the patient is benefitting. Throughout the study patients will be monitored for any side effects.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged ≥18 years, male and female
* Able to eat a high-fat breakfast within a 30-minute period, as provided by the study site
* Histologically or, where appropriate, cytologically confirmed malignant solid tumour refractory or resistant to standard therapy and for which no suitable effective standard therapy exists
* ECOG performance status ≤2
* Normal organ and bone marrow function measured within 28 days prior to administration of IP as defined in protocol

Exclusion Criteria:

* Participation in another clinical study with an IP during the last 14 days (or a longer period depending on the defined characteristics of the agents used)
* Patients receiving any systemic chemotherapy or radiotherapy (except for palliative reasons) within 2 weeks prior to study treatment (or a longer period depending on the defined characteristics of the agents used).
* Toxicities (≥CTCAE Grade 2) caused by previous cancer therapy, excluding alopecia
* Patients unable to fast for up to 14 hours or who have type I or type II diabetes
* Patients who have gastric, gastro-oesophageal or oesophageal cancer
Shenfu Injection for Postoperative Delirium (SFI for POD)

Surgery or trauma may cause serious problem to patients, especially for senile ones, like postoperative delirium or more postoperative complications. Here, we conduct a investigation of SFI for preventing the happening of POD or postoperative complications.

SFI(Shenfu Injection), a historical medical herbal medicine of traditional Chinese, which may produced much benefit to clinical patients with furtigue after major surgery, because it was a comment sense to think of energy loss if they experience surgical damage. Here, we administrated intravenously SFI into senile patients, who receiving hip fracture surgery, to avoid bad results or serious postoperative outcomes, in case of enhancing recovery after surgery.

Eligibility Criteria:
Inclusion Criteria:

* hip fracture surgery under epidural anesthesia

Exclusion Criteria:

* Severe dementia, hearing/vision impairment, coma, etc., unable to communicate;
* patients with end-stage diseases such as tumor;
* 3 months after myocardial infarction, cerebral infarction;
* severe heart, liver and renal dysfunction.
The Use of Intensive Care in Critically Ill Cancer Haematological Patients: "TRIAL-OH"

The purpose of this study is to determine:

* Condition of intensive care unit (ICU) admission in patients with haematological malignancies.
* ICU hospital and up to one year mortality.
* Assessment of post ICU burden and health related quality at 90-d and 1 year.

1. To identify prognostic factors of short and medium term mortality, by underlining the respective weights of organ dysfunction and characteristics of underlined malignancy
2. Evaluate the health related quality of life of intensive care survivors(SF36)
3. Impact of intensive care on families burden (HADS, IES).
4. Assess clinicians' satisfaction ( intensivists, haematologists and intensive care nurses) in relation to medical decision-making.
5. Establish the relevance of antifungal treatments.

Eligibility Criteria:
Inclusion Criteria:

* Hematological malignancies
* hospitalization in ICU
* age \>= 18 years

Exclusion Criteria:

* Patients who have already participated to TRIAL-OH
The Impact of Rapid Diagnostic Methods in the Diagnosis of Fungal Infections in Intensive Care Units of Assiut University Hospital

The diagnosis of invasive fungal disease remains challenging in the clinical laboratory. The use of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) for the identification of filamentous fungi as well as its application for antifungal resistance testing and strain typing Will be evaluated.

Fungal infections are life-threatening opportunistic infections that have emerged as a major cause of morbidity and mortality in critically ill patients. Yeast infections,mainly Candida spp., remain much more frequent than mold infections. Among mold infections, Aspergillus spp. represent the most frequently isolated filamentous fungi in these circumstances .Candida species are the most common cause of nosocomial fungal infections and the fourth most common source of hospital-acquired infections. Candidiasis is an infection caused by Candida, mostly limited to the skin, nails and mucous membranes. However, it can cause serious systemic infections. Candidiasis is an opportunistic infection occurring in presence of predisposing factors like extensive and prolonged administration of broad-spectrum antimicrobials, corticosteroids, immunosuppressive agents and cytotoxic drugs, diabetes mellitus, HIV, chronic renal failure, haemodialysis, renal transplantation or indwelling urinary catheter.The pathogenicity of Candida spp. is related to a combination of microbial factors such as their ability to grow at 37°C, polymorphism, biofilm formation, hydrolytic enzyme secretion, and phenotypic switching. Candida species are identified by different phenotypic methods including examination of their morphological features, analysis of their ability of carbohydrates assimilation and/or fermentation, and their ability of assimilating different nitrogen compounds. Numerous antifungal classes are used to treat Candida infections; polyenes, azoles, echinocandins and allylamines. These antifungals are used with varying efficacy depending on the type, site of infection and the susceptibility of different Candida species. Azoles are the most frequently used antifungal drugs to treat Candida infections as they achieve high success rates even over short durations of therapy. However, resistance among previously susceptible Candida species has emerged following the expanded use of antifungal agents. Antifungal susceptibility testing methods including broth dilution, disk diffusion and E test are now available with species-specific breakpoints developed by The Clinical and Laboratory Standards Institute (CLSI) for multiple antifungal agents.

Eligibility Criteria:
Inclusion Criteria:

* Patients of all age group and both sex with clinically suspected fungal infection at intensive care units of Assiut university hospital will be included.

Exclusion Criteria:

* -Patients who are on antifungal treatment and refuse to take part will be excluded from the study.
Construction of a Questionnaire on Panic Disorder and Agoraphobia

For the first time panic disorder and agoraphobia are included as separate disorders in the DSM-5. Thus, agoraphobia no longer represents a subcategory of panic disorder. To diagnose both of the disorders, questionnaires are the method of choice. However, there are no measuring instruments available free of charge in German-speaking countries. In order to improve this situation, the Witten Panic Disorder Questionnaire (WPF) and the Witten Agoraphobia Questionnaire (WAF) are constructed in accordance with the DSM-5 criteria. Both measuring instruments are included as a part of a ten instrument battery. WAF and WPF will be delivered to a patient sample of patients with panic disorder and/or agoraphobia as well as depressed patients (discriminant validity). Factor analyzes and item analyses will be conducted.


Eligibility Criteria:
Inclusion Criteria:

Panic Disorder / Agoraphobia / Depression diagnosis via diagnostic interview

Exclusion Criteria:

-
Dipole Density Right Atrial Mapping and Assessment of Therapy In Cavotricuspid Isthmus Flutter

Study to determine the feasibility of the Acutus Medical System in obtaining data to create Dipole Density Maps of electrical activation in the right atrium in patients with typical atrial flutter.


Eligibility Criteria:
Inclusion Criteria:

* Age 18-75 years
* One documented occurrence of typical AFL within the past 6 months
* Be able and willing to sign informed consent

Exclusion Criteria:

* Contraindication to a non-emergent interventional EP procedure
* Require treatment in or access to left atrium
* Had a myocardial infarction within the prior two months
* Had cardiac surgery within the prior three months
* Intracardiac thrombus
* Permanent pacemaker/ICD leads in/through right atrium
* Clinically significant tricuspid valve regurgitation or stenosis
* Cerebral ischemic event (including TIA) in the prior six months
* Pregnant
* Currently enrolled in any other clinical investigation
* Any other significant uncontrolled or unstable medical condition
Pilates, Postural Global Reeducation and Ball Exercises

The purpose of this study is to evaluate and compare the effects of three Exercise Movement Techniques Global Postural Reeducation(RPG), Pilates method and Segmented Dynamic Exercises (SDE) regarding muscular strength and endurance of the trunk, spine mobility and flexibility of the posterior muscle chain.


Eligibility Criteria:
Inclusion Criteria:

* Men and women
* Healthy young adults who do not practice regular exercise
* The individuals could not have prior experience with the techniques covered in this study
* They could not report a history of pain,disease, neurological or orthopedic surgeries in column , upper or lower limbs, joint laxity, nor have history of injury and hamstring muscles in the lower limbs, neurological disorders, obesity, rheumatic disease, labyrinthitis, deformities of the lower limbs and spine
* Individuals could not make use of drugs that affected his balance and muscle strength
* To be framed the individual should also have restricted movement in the test distance of the third finger to the ground

Exclusion Criteria:

* Individuals with excessive absences (more than 20% of sessions) or those who missed and could not reset the session in the same week were excluded -Individuals who needed to undergo some surgery or any medical treatment during the duration of the study, or those who give up without completing the minimum time of the intervention
Thyroid Cancer and Photoacoustic Imaging

The aim of this study was to evaluate the usefulness of photoacoustic imaging in thyroid nodules. In addition, we would like to confirm the relationship between the results of photoacoustic imaging and histopathologic findings when thyroid nodules were diagnosed as thyroid cancer.


Eligibility Criteria:
Inclusion Criteria:

* All thyroid nodule identified as benign or as thyroid cancer

Exclusion Criteria:

* Patient refuses to participate in the study or withdraws consent
CtDNA Liquid Biopsy for Early Assessment of Residual Disease in HPV-associated Head and Neck Cancer (Clear-HPVca)

The purpose of this study is to test a new liquid biopsy assay for detecting residual disease after surgery in patients with HPV-associated head and neck cancer.

Human papillomavirus associated head and neck squamous cell carcinoma (HPV+HNC) is the most common HPV-associated cancer in the United States. Surgery is a common approach for primary treatment of early-stage HPV+HNC. Many patients who undergo surgery receive adjuvant radiation or chemoradiation therapy to treat potential residual disease, which is currently predicted based on clinicopathologic risk factors including positive margins, extranodal extension, multiple positive lymph nodes, vascular invasion, and lymphatic invasion. However, there are limitations in predicting residual disease based on the use of these features alone - the use of clinicopathologic risk factors for prediction is non-standardized and has poor individualized predictive and prognostic capacity. Currently, there are no established biomarkers to predict residual disease.

Circulating tumor DNA (ctDNA) is an emerging minimally invasive prognostic biomarker, for detecting molecular residual disease (MRD) and predicting recurrence in multiple solid cancers. Prospective trials in cancers such as colorectal cancer have demonstrated not only strong Disease Free Survival (DFS) prognostic capacity but also Overall Survival (OS). Previous studies have demonstrated that HPV+HNCs release circulating tumor HPV DNA (ctHPVDNA) into the blood where it serves as an accurate real-time biomarker of disease status after surgery. In patients without pathological risk factors, ctHPVDNA is rapidly cleared after surgery. In patients with residual disease, ctHPVDNA remains elevated after surgery. However, initial studies have showed that patients with microscopic levels of residual disease are often not detected by current approaches using droplet digital PCR (ddPCR), suggesting significantly more sensitive assays are necessary.

HPV-DeepSeek is an HPV whole genome next-generation sequencing assay which is significantly more sensitive than ddPCR-based approaches. We aim to conduct a prospective observational cohort study of HPV+HNC patients treated with curative intent surgery to test the primary hypothesis that patients with MRD detection after surgery will have inferior 2-year DFS and OS and the secondary hypothesis that patients with MRD detection after treatment completion (surveillance) will have inferior 2-year DFS and OS.

Eligibility Criteria:
Inclusion Criteria:

* Greater than or equal to 18 years of age
* Newly diagnosed, untreated, histologically confirmed HPV-associated head and neck cancer
* Scheduled for curative intent resection as primary treatment
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

Exclusion Criteria:

* Not meeting all inclusion criteria
* Pregnant
* Receiving treatment for concurrent second maligancy
Breast Cancer Patients: A Breast Cancer Rehabilitation and Exercise Laboratory

The proposed study compares the outcomes of a physical activity intervention begun at diagnosis, continuing through active cancer treatment and into six months of survivorship compared to the outcomes of a control group receiving limited information on activity.

Patients (with stage 0 to stage III breast cancer)receiving chemotherapy, radiation or both chemotherapy and radiation will be included in the study.Randomization will be stratified by disease stage at diagnosis, treatment modalities planned, and hormonal status. Each patient will have a weekly goal of 2000 calories burned and 18 MET-hours of exercise which can be achieved in 4 to 7 hours of physical activity per week. Resistance training, using weight machines and aerobic training using treadmills, elliptical trainers and stationary bicycles, will be utilized in the intervention group. The control group will receive basic information on physical activity but not be instructed. Any physical activity in this group will be self-reported. Change in C-reactive protein will be the primary endpoint. Changes in other laboratory values, DEXA measurements, and quality of life measurements will be secondary endpoints.

Eligibility Criteria:
Inclusion Criteria:

1. Consent to participate in study
2. Women aged 18 and older
3. Stage 0 to III breast cancer prior to any treatment and at time of diagnosis
4. Requires treatment that includes chemotherapy, radiation therapy or both chemotherapy and radiation therapy
5. Adequate fitness to participate in a physical activity as assessed by the investigator
6. Willing and able to participate in a prescribed exercise program

Exclusion Criteria:

1. Metastatic breast cancer (Stage IV)
2. Initiation of treatment regimen prior to enrollment
3. Treatment for breast cancer not requiring chemotherapy or radiation therapy
4. Patients who are pregnant (negative urine pregnancy test required at baseline to determine eligibility in women of child bearing potential).
5. Currently lactating
6. Do not read, understand, or speak English

Eligible participants will not be included if they have:

1. known cardiac disease,
2. uncontrolled hypertension,
3. uncontrolled thyroid disease,
4. diabetes mellitus,
5. mental illness,
6. infection,
7. immune or endocrine abnormality,
8. body weight reduction I10% in past 6 months, and
9. positive exercise stress test.
10. Major surgery within last 6 months that requires exercise restriction
Analysis of Change of Optic Nerve Sheath Diameter in in Patients Operated for Urological Reasons

The assessment of the diameter of the optic nerve sheath (ONSD) using ultrasound can be a very helpful tool in the assessment of increased intracranial pressure in patients operated for urological procedures.

Advantages of using ultrasound in the assessment of intracranial pressure:

simple, bedside examination, repetitive, generally available, cheap, no exposure to X-rays, no need to transport the patient to the CT laboratory

Differential diagnosis:

Widening of the size of the optic nerve sheath outside of increased intracranial pressure may occur in the following pathologies:

optic neuritis optic nerve injuries meningioma of the optic nerve arachnoid cyst around the optic nerve tumors of the cavernous sinus Blood edema may occur due to impaired blood flow. The research is to determine whether the patient's position for urological procedures is safe for the patients and whether as a result of staying in such a position there is no development of cerebral edema.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing urologic operation
* Adults 18 to 90 years of age
* American Society of Anesthesiologists Physical grade 1-3

Exclusion Criteria:

* Patients who did not agree to participate in the study
* Patients with ophthalmic diseases
* Patients with previous history of ophthalmic surgery
* Patients with neurological disorders
* Patients with history of head surgery due to neurological disorders
* Patients with history of disease with increased intracranial pressure
* Patients with history of disease with increased intraocular pressure
Vitamin D Supplementation During Lactation

This randomized, placebo-controlled trial in Thai pregnancy is conducted. The study aims to determine whether vitamin D3 1,800 IU/d supplementation in lactating mother improves vitamin D status of breastfed infant.

Vitamin D deficiency in pregnancy increases risk of gestational diabetes mellitus, pre-eclampsia, preterm birth, low birth weight and cesarean section. To against these adverse events, vitamin D supplementation in pregnancy and lactation is recommended, but dose ranges are varied. Then, this study is carried out in lactating mothers and their breastfed infants with maternal 25 Hydroxy-vitamin D (25OHD) levels of 10-30 ng/ml in third trimester. Subjects are divided into 2 groups, one is randomly assigned to 1,800 IU/d compared with maternal and infant controls receiving placebo. Maternal serum 25OHD and milk VitD will be measured by LC-MS/MS during lactation, and on cord blood at 6 weeks breastfed infants. This study is submitted for ethical consideration by relevant Ethics committee.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant Thai women and intends to deliver at Rajavithi Hospital
* Insufficient Vitamin D levels (25(OH)D \< 30ng/ml)
* Gestational age at birth and no complications

Exclusion Criteria:

* Age \< 18 years old
* Unintended to deliver at Rajavithi Hospital
* Insufficient Vitamin D levels (25(OH)D \< 10ng/ml)