cyrilzakka/clinical-trials huggingface dataset:
Anesthesia for Pain After Ankle Fracture Surgery

This pilot study will test the hypothesis that prolonged regional peripheral nerve block will reduce development of chronic pain in patients undergoing surgery for ankle fracture compared to standard of care. Subjects will be followed for one year.

This pilot study will test the hypothesis that prolonged regional peripheral nerve block will reduce development of chronic pain in patients undergoing surgery for ankle fracture. Regional nerve block using local anesthetics delivered by ambulatory pump is used in some types of surgeries but is not routine for ankle fracture patients in our hospitals. Patients will be randomized to standard care (single shot peripheral nerve block prior to surgery) or experimental (the same single shot nerve block, followed by continuous popliteal nerve block with ropivacaine starting just after surgery). The primary outcome will be scores on a validated ankle/foot pain questionnaire that includes questions on function. Subjects will be followed for one year. Secondary outcome will be postoperative opioid use.

Eligibility Criteria:
Inclusion Criteria:

* Referred for surgery for open reduction and internal fixation for ankle fracture

Exclusion Criteria:

* Unable to give informed consent in English
* Unable to complete surveys in English
* Unable to understand instructions for using pump in English
* Unavailable for followup
* Polytrauma; undergoing other surgeries or having other orthopedic injuries related to the precipitating cause of the ankle fracture
* Infection
* Peripheral vascular disease
* Diabetes
* Currently undergoing chemotherapy
* Pregnancy
* Currently lactating
* Heart disease or heart rhythm disorder or taking anti-arrhythmic drugs
* Severe renal impairment (Class 3 or worse kidney disease)
* Liver disease (cirrhosis or liver failure)
* Prior allergic reaction to any type of local anesthetic
* Taking therapeutic doses of anti-coagulants or anti-platelet therapy (prophylactic doses started because of hospital admission are not an exclusion)
* Currently taking antidepressants or other psychiatric medications
* Single shot local nerve block prior to surgery was ineffective
* Selected for neuraxial anesthesia rather than general anesthesia for the open reduction surgery
* Already receiving chronic analgesic therapy for a separate chronic pain condition
Nurses Education Using Virtual Social Network

Regardless of the method used to measure BP, initial and ongoing training of technicians and healthcare providers and the use of validated and calibrated devices are critical for obtaining accurate BP measurements.

Shortage of human resources and the importance of remaining up-to-date to provide healthcare services highlighted the development of distance education for nurses. In addition information presented via the distance learning method via software systems was more stable than the face-to-face method via lecture, and it saved time and energy. Nurses are responsible for BP monitoring and assessment in the clinical setting. Finding new strategies for distance education is of great concern and ,compared with traditional face-to-face interventions, those carried out through social networks have the advantage that the participant does not need to attend the sessions in person, and offers unlimited access to the intervention materials whenever they wish.

Eligibility Criteria:
Inclusion Criteria:

* Only permanent staff nurses working in the two cardiac units.
* Nurses of both sexes .
* Nurses who use a smart phone or any other digital device with the ability to install the social network of whatsapp.

Exclusion Criteria:

* Inaccessibility to wireless net work
* Unwillingness to participate in study
* Failure to fill pretest questionnaire
Honey Used as Adjunct Therapy to Tylenol for Post-Op Tonsillectomy Patients

Tonsillectomies are the second most common surgery with over half a million procedures in the United States for 2006. Tonsillectomies are considered a painful surgical procedure performed on children resulting in pain and nausea/vomiting for up to 7 days postoperatively. Up until recently, doctors have been prescribing upwards of ten days' worth of opioid pain medication for children following tonsillectomies due to the high incidence of pain expected afterwards. Effective July 1st, 2018, new laws regarding opioid restrictions came into place that restricted doctor's abilities to write for more than three days' worth of opioid pain medication without having to fill out sizeable amounts of additional paperwork. This law was put in place to combat the ongoing opioid epidemic that plagues this country. What the investigators are left with for the treatment of pain following these procedures are simply Tylenol and Motrin with a limited amount of opioid. With this being considered a highly painful surgery with a difficult recovery, more options are needed to effectively treat pain and reduce the incidence of emergency room visits and phone calls to the clinic regarding pain control in the postoperative period.

Studies in Europe have shown that honey is an effective adjunct treatment option in the reduction of pain in pediatric postoperative tonsillectomies. These studies are few and far between and more research needs to be conducted to validate these claims particularly in the United States where research on this subject has been extremely limited. Further, the extent to which families and health care providers in the United States would be receptive to using honey for children's postoperative pain is unclear since honey is considered a complementary and alternative medicine (CAM) intervention.


Eligibility Criteria:
Inclusion Criteria:

* English-speaking families
* male or female
* 2-17 years old undergoing a routine tonsillectomy procedure.
* English speaking families in the waiting room whose children are having any type of surgery during the time period we are enrolling the tonsillectomy patients.

Exclusion Criteria:

* Subjects will be excluded for any of the following reasons: Any child undergoing or has already undergone a tonsillectomy who has a genetic syndrome or developmental disability (e.g., Trisomy 21, Angelman Syndrome, etc.) which could impact the course of postoperative pain management.
* Any child who has an allergy to honey.
* Non English speaking families.
Reaching Out to the UNdiagnosed People Infected With Blood Borne Viral Infections

Title Reaching out to the UNdiagnosed people infected with blood-borne viral infections (RUNtoBBV) Objectives 1. To study the efficacy of an outreach methodology to increase the uptake for screening, linkage to care and treatment in (active or former) people who use drugs (PWUD) Trial design Prospective multicenter interventional cohort design Number of subjects 336 inclusions (with prevalence of HCV Ab: 30%)

* 168 Antwerp
* 168 Limburg

Selection criteria Inclusion criteria:

* 18 years of age
* History of/ or active drug use
* Written informed consent obtained Exclusion criteria
* Currently enrolled in centralized OST program of Free Clinic or CAD Limburg Endpoints The following endpoints will be compared between the centers in Limburg and Antwerp: (Main outcome in bold)

Main objectives:

* Prevalence of blood-borne viral infections in Belgian (former or active) PWUD:

  * HCV infection (number of HCV Ab+ / number of screened PWUD)
  * HBV infection (number of HBsAg+/number of screened PWUD)
  * HIV infection (number of HIV Ab+/number of screened PWUD)
* Analysis of linkage to care to hepatologist/ infectiologist (number of patients who adhered to their consultation/number of referred patients)

Secondary objectives:

* Analysis of risk behavior/sociodemographics linked to presence of BBV infections
* Analysis of uptake of anti(retro)viral treatment (number of patients started on treatment/number of patients needing treatment)
* Analysis of treatment adherence (adherence to treatment consultations/total planned consultations)
* Analysis of treatment outcome (total number of cured or virally suppressed patients/total number of treated patients)


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age
* History of drug use
* Active drug use
* Written informed consent obtained

Exclusion Criteria:

* Currently enrolled in OST program of Free Clinic or CAD Limburg (centralized OST provision)
Efficacy and Safety of Vildagliptin Compared to Placebo in Patients With Type 2 Diabetes and Mild Hyperglycemia

This study is not being conducted in the United States. Key long-term clinical studies have shown that people with type 2 diabetes should try to achieve overall blood glucose levels as close to normal as possible. The purpose of this study is to assess the safety and effectiveness of vildagliptin, an unapproved drug, compared to placebo in lowering overall blood glucose levels in people with type 2 diabetes who have not been previously treated with drug therapy to lower their blood sugar and whose blood glucose levels are close to normal.


Eligibility Criteria:
Inclusion Criteria:

* Blood glucose criteria must be met
* Not currently on drug therapy for type 2 diabetes
* Body mass index (BMI) in the range 22-45
* Diagnosis of type 2 diabetes for at least 8 weeks

Exclusion Criteria:

* Pregnancy or lactation
* Type 1 diabetes
* Evidence of serious diabetic complications
* Evidence of serious cardiovascular complications
* Significant laboratory abnormalities as defined by the protocol
* Other protocol-defined exclusion criteria may apply
Brain Ion Homeostasis, Lithium and Bipolar Disorder

In this project, investigators intend to carry out the first simultaneous, in vivo, imaging study of lithium content and sodium ion homeostasis in the brain of Bipolar Disorder (BPD) patients under Lithium therapy.

The purpose of this study is to validate a new method for the measurement of the amount of lithium (also known as lithium concentration) in the brain of subjects undergoing lithium treatment for bipolar disorder. The method involves the use of Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) techniques. These are non-invasive techniques, with no known harmful effects, that allow investigators to measure the amount of lithium in an individual's brain. There will be no contrast dye used in this study.

Eligibility Criteria:
Inclusion Criteria:

* Psychiatrically stable patients (diagnosed according to the Diagnostic and Statistical Manual, DSM-IV, criteria)
* On steady state serum lithium levels (0.8-1.2mEq/L)

Exclusion Criteria:

* Subjects who have a history of head trauma
* Subjects who have a contraindication for an MRI exam, including a claustrophobia, surgical or vascular implants, pregnancy, pacemakers, neurostimulators, history of metal in the eyes, and orthodontia or extensive bridgework (with have a particular impact on gradient echo imaging).
Mitochondrial Diseases - Long-read Genome and Transcriptome Sequencing in Cases Unresolved After Short-read Genomics

The MiDiSeq project will enroll 20 unresolved index patients with suspected mitochondrial disease prioritized for genomic analysis.

In the MiDiSeq (monocentric, prospective, open-label diagnostic) project, patients with suspected mitochondrial disease prioritized for i) high a priori probability for a genetic basis (e.g. positive family history) as well as availability of (ii) fibroblast cell lines with a biochemically defined phenotype, (iii) parental samples, (iv) short read whole genome and transcriptome datasets and (v) optional additional metabolomics and proteomics data.

The following questions will be leading the project:

i) to systematically benchmark different sequencing technologies to detect genetic and epigenetic variation and their impact on gene regulation.

(ii) to further develop algorithms for integrative analyses of different 'omics datasets.

(iii) to expand the analysis from coding Single-Nucleotide Variants (SNVs) and regulatory mutations to structural variants (SVs), repeat expansions and contractions, low complexity regions and epigenetic signatures.

(iv) to identify novel alterations and disease mechanisms. (v) to gain fundamental new insights into disease mechanisms and cellular biology.

(vi) to improve genetic diagnostics of future rare disease patients and to evaluate personalized therapeutic options.

Eligibility Criteria:
Inclusion Criteria:

Unclear diagnosis Suspected genetic cause of the disease

Exclusion Criteria:

Missing informed consent of the patient/ legal guardian
Diagnostic Values of Lung Ultrasound for Perioperative Atelectasis

Lung ultrasound offers a novel, reliable and radiation-free tool for diagnosing perioperative atelectasis and evaluating its severity in adult patients undergoing general anesthesia in the operating room.

Atelectases occur in up to 90% of patients undergoing general anesthesia and intubation. The aim of the present observational study was designed to further to evaluate the diagnostic performance of lung ultrasound (LUS) in detection of postoperative atelectasis in adult patients undergoing general anesthesia. Results of LUS as the experimental method will be compared to the results of computed tomography (CT) as the reference technique for the detection of atelectasis. The investigators want to confirm former findings of the appearance of perioperative atelectases and to prove that ultrasound is a valid tool for detection of atelectases.

Eligibility Criteria:
Inclusion Criteria:

1. Aged 18 years and older;
2. American Society of Anesthesiologists (ASA) physical status within class I-III;
3. Scheduled for selective neurosurgical operation with general anesthesia;
4. Need of mechanical ventilation more than 2 hours;

Exclusion Criteria:

1. Patients decline to participate;
2. Pregnancy;
3. Previous thoracic procedures (thoracic drain, thoracotomy, thoracoscopy);
4. A history of pulmonary diseases within last two weeks with abnormal manifestation of lung CT (pulmonary parenchyma or/and interstitial lesions );
5. Pneumothorax or subcutaneous emphysema during peri-operation;
6. Patients with a body mass index (BMI) more than 30 kg/m2;
7. Emergency operation.
Effects of Propofol Induction Anaesthesia on the Heart Rate Variability

The ANS plays an important role in the regulation of hemodynamics during anesthesia. Manually blous of propofol during induction anesthesia is reported to reduce both sympathetic and parasympathetic tone; however, it is not clear whether the changes in heart rate variability are associated with propofol concentration.

Because the ANS, especially the sympathetic nervous system, plays a major role in regulating cardiovascular homeostasis, knowledge of how anesthetic agents modify sympathetic activity is important for understanding subsequent cardiovascular responses.

Spectral analysis of heart rate variability (HRV) is a promising new approach, widely used, noninvasive technique to assess the autonomic indexes of neural cardiac control and has been correlated to the integrity and balance of the sympathetic and parasympathetic activation status. The presence of low-frequency (LF) and high-frequency (HF) oscillatory rhythms in the variability of the R-R interval (RRI) is well established. To date, it is believed that LF is mediated by the parasympathetic and sympathetic systems, whereas HF is mediated primarily by the parasympathetic system. There has been a lot of methodological analysis developed to evaluate the ANS function during anesthesia. In this study, Continuous Wavelet Transform (CWT), believed as a reliable and robust method to access cardiorespiratory dynamics of the ANS due to its adaptability and adjustability between spectral and temporal scale using a window of variable width, was used as a method for analyzing dynamic cardiovascular signals during anesthesia.

Eligibility Criteria:
Inclusion Criteria:

* The subjects were selected from patients scheduled for surgery under general anesthesia.

Exclusion Criteria:

* recent administration of sedative or opioid drugs, emergency surgery and impairment of renal, hepatic, cardiac or respiratory function.
Emotional Disorders and Outcomes in Adults With Type 2 Diabetes Mellitus at Primary Care

This study aims to determine which factors are related to change in diabetes-related distress and change in depressive symptoms after three years of follow-up in Asian adults with type 2 diabetes mellitus in primary care. The investigators will explore the impact of patient demographics, cardiometabolic control, medications adherence, health-related quality of life, self-efficacy and self-management behaviors on diabetes-related distress and depressive symptoms.

Patients with type 2 diabetes mellitus (T2DM) have been shown to experience psychological burden and distorted illness perception. These psychological burden include feeling of burned-out, fatigue, distress and depression, and in addition of distorted illness perception often lead to difficulty in coping with the demands of life-style changes and adherence to medication. Diabetes-related distress (DRD) and depressive symptoms (DS) were associated with glycaemic control and medication adherence, and life-styles behaviors, respectively. However, evidence on the relationships between DRD, DS and clinically significant outcomes are scarce in Asian adults with T2DM. Primary care patients who participated before will be re-invited. This is a repeated cross-sectional study of a cohorts of 700 patients who were first studied in 2013 (Emotional Distress in adults with type 2 Diabetes Mellitus \& Quality of Life \[EDDMQoL\] study with the National Medical Research Register (NMRR) identification number: NMRR-12-1167-14158). Demographic data (age, gender, ethnicity, religion, educational level, occupation and monthly income), smoking status, self-perceive social support and health literacy will be collected by questionnaires.

Eligibility Criteria:
Inclusion Criteria:

1. Those who participated in the EDDMQoL study
2. Adults aged at least 30 year-old
3. Diagnosed of T2DM more than three years ago
4. On regular follow-up with at least three visits in the previous year

Exclusion Criteria:

1. Patients who are pregnant or lactating
2. Having psychiatric/psychological disorders that could impair judgments and memory
3. Patients who cannot read or understand English, Malay or Mandarin
Simplification of Complex Insulin Regimens With Preserving Good Glycemic Control in Type 2 Diabetes

This study examines prospectively the safety and efficacy of switching from multiple daily insulin injections (MDI) to once daily IDegLira (insulin degludec and liraglutide fix ratio combination), a fixed-ratio combination of insulin degludec and liraglutide, in relatively well controlled (HbA1c\<7.5%) subjects with type 2 diabetes using low total daily insulin dose (TDD).

Type 2 diabetic patients suffering from severe hyperglycemia are often apply multiple daily insulin injections (MDI). If glucose toxicity resolves, the regimen may potentially be simplified, but there are no specific guidelines regarding this and a lot of patients are left on MDI.

The Investigators aimed to examine prospectively the safety and efficacy of switching from MDI to once daily IDegLira, a fixed-ratio combination of insulin degludec and liraglutide, in relatively well controlled (HbA1c\<7.5%) subjects with type 2 diabetes using low total daily insulin dose (TDD).

The investigators hypothesize that in everyday clinical practice switching from low dose MDI to IDegLira in patients of different ages with well-controlled (or overcontrolled) type 2 diabetes is safe, may induce weight loss and result in similar or better glycemic control.

Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetic (T2D) patients \>18 years old
* detectable random, non-fasting serum C-peptide levels
* HbA1c=\< 7.5%
* treated with MDI (with stable daily doses of insulin at least for 90 days prior to baseline visit)
* using relatively low total daily insulin dose (TDD), at baseline visit low TDD is defined as TDD\<70 IU/day and TDD\<0.6 IU/kg/day at the same time.

Exclusion Criteria:

* Type 1 diabetes
* treatment of T2D with any medication for diabetes other than insulin or metformin during 90 days before baseline visit
* active cancer
* anaemia (haemoglobin \<100g/l)
* acute or chronic kidney disease with an estimated glomerular filtration rate \<30 mL/min/1.73 m2
Renal Failure Following Lung Transplantation in Cystic Fibrosis Patients

With this retrospective observational cohort study, we performed a longitudinal assessment of the renal function of the adult CF patients who underwent LUTX, aiming 1) to describe possible risk factors associated with perioperative AKI and 2) to describe AKI short and long term effects on clinical outcomes.

This study is a retrospective analysis of prospectively collected data from medical records of all consecutive CF patients who underwent LUTX at our Institution from January 2013 to December 2018.

Eligibility Criteria:
Inclusion Criteria:

* All patients with CF who underwent LUTX during the study period were considered.

Exclusion Criteria:

* single LUTX
* re-transplantation
* missing medical records;
* age \< 18 years old
Impact of EUS Guided Treatment of Gastric Varices

The purpose of the study is to determine the clinical impact of cyanoacrylate tissue adhesive treatment for Gastric Varices performed by Indiana University EUS physicians.

Using an IRB approved database (IU IRB#1209009522; NCT02037659), data collected from the database will be evaluated to identify complications, risk of rebleeding, death within 1 year of treatment, varices eradication and need for re-intervention associated with cyanoacrylate tissue adhesive (Dermabond) treatment performed by Indiana University Endoscopic Ultrasound (EUS) physicians.

Eligibility Criteria:
Inclusion Criteria:

* Any subject enrolled into the existing database (IU IRB#1209009522; NCT02037659).

Exclusion Criteria:

* Not enrolled into the database.