cyrilzakka/clinical-trials huggingface dataset:
Cross Education Effect of Balance Program in Patients With Ankle Instability

Researchers recommended that NeuroMuscularControl (NMC) training should not begin immediately after an acute Lateral Ankle Sprain(LAS) because of pain and weight-bearing restrictions. So, there is a need for an alternative way by which we can begin NMC retraining sooner. By training the non-affected ankle (Cross education), clinicians can begin NMC retraining before the individuals can bear weight on the affected ankle, in the acute stage of healing, or even if there is any other precautions or contraindications to exercise due to the injuries. Athletes with more chronic injuries may be able to perform NMC and functional retraining at higher levels than otherwise would be possible by initiating the training on the non affected ankle. Initiating these activities on the non-affected ankle will result in earlier improvements in postural control and function in the affected ankle.

By this way, the rehabilitation times will be short, athletes can return earlier to sport participation or work, health care costs will decrease. Up to the knowledge of the author, there is a gap in research investigating cross education effect of balance program in patients with ankle instability. So, the current study was conducted to reveal the role of this phenomena in such cases and add this phenomenon on the physical therapy field to manage patients with ankle instability (If Cross Education phenomena is effective, this phenomena will be used in rehabilitation).

Thirty five females with Chronic Ankle Instability will be recruited from the Faculty of Physical Therapy, Cairo University by announcements to participate in this study. They will be randomly assigned into three groups; (A) Cross Education (balance training for the non affected side )(n=10), (B) Traditional training(balance training for the affected side) (n=10), (C) control group (no intervention) (n=15). stability indices measured by the Biodex Balance system , Single Leg Stance Test and scores of Star Excursion Balance Test will be assesssed before and after six weeks of Single Leg Balance training.

Eligibility Criteria:
Inclusion Criteria:

* At least 1 ankle sprain, with the initial sprain occurring more than 1 year before the study
* A feeling of ''giving way'' (at least 2 episodes in the 6 months before the study).
* At least two ''yes'' answers on questions four to eight on the Modified Ankle Instability Instrument (MAII)

Exclusion Criteria:

1. - A history of previous surgeries or fractures in either limb of the lower extremities.
2. - Acute injury to musculoskeletal structures of other joints of the lower extremity in the previous three months, which impacted joint integrity and function (ie, sprains, fractures) resulting in at least one interrupted day of desired physical activity.
3. - Balance deficits due to vestibular disorders, such as vertebrabasilar insufficiency and/or visual disorders.
4. - Neuropathies and diabetes
Upright Back Posture Device Study

This is a randomized controlled study to determine if patients between the ages of 18-50 years, with posture related low back pain, who use the Upright device demonstrate improved pain control and self perception of posture compared to those given standard ergonomic instruction.

Back pain is a common complaint among students. For many, back pain is directly related to poor posture while sitting and standing. Those who spend prolonged time sitting in poor posture often develop muscular imbalances leading to tight chest muscles and weakness in back muscles. The Upright system is a device which helps provide a sensory reminder to alert users when their posture is poor. The purpose of this study is to determine if patients who use the upright posture device demonstrate improved pain control and self perception of posture when compared to those given standard ergonomic instruction.

Eligibility Criteria:
Inclusion Criteria:

* Postural-related back pain

Exclusion Criteria:

* A diagnosis of significant scoliosis, herniated/bulging disc, lumbar spondylolysis, radiculitis, facet arthrosis, fibromyalgia, rheumatoid arthritis, seronegative spondyloarthropathy.
* Neurologic deficits on exam
* Currently in physical therapy (PT)
Health Impacts of Street Vended Fruits

This study will employ a randomized controlled intervention design to evaluate the health impacts of consuming fresh-cut street-vended fruits, focusing on microbial contamination and gastrointestinal (GI) symptoms. A total of 300 participants will be recruited and divided into treatment (consuming guava, pineapple, or watermelon) and control groups (no fruit consumption). Fruit samples will be analyzed for microbial contamination, including S. aureus and E. coli, using standard microbiological and molecular techniques. Data on GI symptoms will be collected through questionnaires and analyzed using statistical methods, such as Chi-square tests, Kaplan-Meier survival analysis, and Cox proportional hazards regression. Spearman correlation will identify associations between bacterial presence and specific symptoms. Ethical approval will be obtained, and participant safety will be prioritized. Analytical tools, including IBM SPSS, RStudio, and PyCharm, will be utilized for the analyses.


Eligibility Criteria:
Inclusion Criteria:

* Individuals aged 18-60 years.
* Residents of Mymensingh District, Bangladesh.
* Willing to consume fresh-cut street-vended fruits (guava, pineapple, or watermelon) for five consecutive days.
* Individuals with a self-reported history of gastric acidity issues (for the gastric acidity arms).
* Individuals with no history of gastric acidity (for the non-gastric acidity arms).
* Participants who have not taken antibiotics, proton pump inhibitors (PPIs), or antacids in the last two weeks.
* Willing to provide detailed information on their dietary habits and gastrointestinal symptoms through surveys/questionnaires.
* Participants who provide informed consent for participation.

Exclusion Criteria:

* Individuals under 18 years or over 60 years.
* Pregnant or lactating women.
* Those with a diagnosed gastrointestinal disorder (e.g., peptic ulcer disease, irritable bowel syndrome, Crohn's disease).
* Individuals with a history of chronic infections or immune-compromising conditions (e.g., HIV/AIDS, cancer, diabetes).
* Participants who have taken antibiotics, PPIs, or antacids within the last two weeks.
* Individuals with known allergies to guava, pineapple, or watermelon.
* Those who refuse to consume fresh-cut fruits from street vendors.
* Participants who do not provide informed consent or are unable to complete the study period.
The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors

The investigators propose to evaluate the effects of avocado consumption (by incorporating 1 unit of fruit per day into a healthy diet) on multiple cardiovascular disease (CVD) risk factors. The investigators will compare chronic consumption of a moderate fat blood cholesterol-lowering diet incorporating one avocado per day versus a blood cholesterol-lowering Lower-Fat diet on established CVD risk factors including lipids and lipoproteins, and blood pressure (BP). The investigators also will evaluate the effects of an avocado diet on several emerging CVD risk factors. To elucidate the specific benefits of avocado and its accompanying bioactives on the aforementioned risk factors, the investigators will compare the avocado diet with a diet that has the same macronutrient profile (but without the avocado).

A randomized, 3-period cross-over, controlled feeding study was designed to compare the effects of a moderate fat blood cholesterol-lowering diet that provides one avocado per day (total fat = 34% total energy, MUFA=18%, SFA \<7%) to an Average American diet (AAD), Lower-Fat diet (total fat = 24% total energy, SFA \<7%), and Moderate Fat diet (with equivalent fatty acid profile to the avocado diet) without avocado. The study population consists of 40 overweight (BMI25-35 kg/m2) men and women with moderately elevated LDL-C, between the25-90th percentiles from NHANES. The investigators hypothesize that a moderate fat heart-healthy diet, including 1 avocado per day will reduce CVD risk factors including lipids, lipoproteins, apolipoproteins, lipoprotein particle size, markers of oxidative stress and inflammation, blood pressure and reverse cholesterol transport compared to an AAD, Lower-Fat diet, and moderate fat diet without avocado.

Eligibility Criteria:
Inclusion Criteria:

* healthy non-smoking
* overweight (BMI 25-35 kg/m2) men and women
* LDL-C between the25-90th percentile from NHANES: 105-194mg/dL for males; 98-190mg/dL for females)

Exclusion Criteria:

* BP \>140/90 mmHg;
* A history of myocardial infarction, stroke, diabetes mellitus, liver disease, kidney disease, and thyroid disease (unless controlled on medication);
* Lactation, pregnancy, or desire to become pregnant during the study;
* Cholesterol-lowering medication use;
* Intake of putative cholesterol-lowering supplements (psyllium, fish oil capsules, soy lecithin, niacin, fiber, flax, and phytoestrogens, stanol/sterol supplemented foods);
* Vegetarianism;
* Nut allergies (Other food allergies were reviewed on a case-by-case basis);
* Refusal to discontinue nutritional supplements, herbs or vitamins
A Phase II Trial of Perioperative Chemotherapy With Oxaliplatin, 5-Fluorouracil, Leucovorin(MODIFIED FOLFOX6) in Patients With Locally Advanced Operable Gastric Cancer

The role of perioperative chemotherapy in potentially operable advanced gastric cancer (AGC) with regional lymph node metastasis is still in the area of controversy. The aim of this study is to evaluate the efficacy and toxicity of folinic acid (FA), infusional 5-fluorouracil (5-FU), and oxaliplatin (modified FOLFOX6) in potentially resectable AGC with regional lymph node (LN) metastasis.


Eligibility Criteria:
Inclusion Criteria:

* Previously untreated patients with pathologically proven advanced gastric adenocarcinoma with regional LN metastasis (clinical stage: cT2-4 and N+)
* At least one measurable regional lymph node metastasis according to the Response Evaluation Criteria in Solid Tumors (RECIST v. 1.0)
* age between 18 and 75 years
* Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1
* no prior chemotherapy or radiotherapy
* adequate bone marrow, hepatic and renal function (absolute neutrophil count \[ANC\] ≥ 1.5ⅹ109/L, platelet count ≥ 100ⅹ109/L, total bilirubin ≤ 1.5ⅹupper limit of normal \[ULN\], serum transaminases ≤ 2.5ⅹULN, alkaline phosphatase ≤ 2.5ⅹULN, serum creatinine ≤ 1.5ⅹULN or actual or calculated creatinine clearance ≥ 50 mL/min).

Exclusion Criteria:

* clinical stage T1 tumors
* clinical or radiologic evidence of distant metastasis
* intestinal obstruction or impending obstruction
* active tumor bleeding
* interstitial pneumonitis or symptomatic pulmonary fibrosis
* peripheral neuropathy of National Cancer Institute Common Toxicity Criteria (NCI-CTC) grade ≥1
* pregnant or breastfeeding patients
* other serious diseases
Assessment of Quality of Life of Children With Chronic Idiopathic Thrombocytopenic Purpura (Kid's ITP Tools)

Assessment of quality of life of patient with chronic idiopathic thrombocytopenic purpura according to the type of treatment


Eligibility Criteria:
Inclusion Criteria:

* children with Idiopathic thrombocytopenic purpura
* aged between 1 and 17 year
* Idiopathic thrombocytopenic purpura persistent at 12 months
* obtention of informed consent

Exclusion Criteria:

* Persistant/acute Idiopathic thrombocytopenic purpura
* concomittant chronic disease, stabilized or not
* Concomittant disease with life expectancy \< 1 year
* Person who have not belong to a social security scheme
* Secondary Idiopathic thrombocytopenic purpura
Preoperative Inspiratory Muscle Training Effects on the Perioperative Inflammatory Reaction in Cardiac Surgery.

This study evaluates the impact of preoperative high-intensity inspiratory muscle training (IMThi) before cardiac surgery on perioperative inflammatory response. Half participants will receive high intensity inspiratory muscle training and the others a sham inspiratory muscle therapy.


Eligibility Criteria:
Inclusion Criteria:

* Waiting for thoracic surgery with valve replacement
* Preoperative surgeon consultation between 3 and 6 weeks before surgery

Exclusion Criteria:

* Patient with antecedent of lung surgery
* Patient with neuromuscular or neurovascular disease
* Non anticipated surgery with a time between surgeon consultation and surgery inferior to 3 weeks.
* Inhability to do the preoperative exercises
In-Hospital Hyperglycemia: Effects of Treatment on Glycemic Control and Clinical Outcome

To improve glycemic control of inpatients admitted to the internal medicine wards, the researchers generated a protocol based on intensive insulin treatment for use in all inpatients with hyperglycemia.

The researchers hypothesize that intensive insulin treatment will improve the glycemic control and the outcome of hospitalized patients.

Study Information:

* All patients with a history of diabetes admitted to the internal medicine ward were enrolled in the study.
* At baseline, demographic and clinical information were obtained, including information necessary to determine the severity of the illness. Venous capillary blood glucose levels were checked 4 times a day by glucometer.
* During the pre-intervention period, patients were treated according to the common practice in the hospital without any intervention. The study team collected the baseline data on the glycemic control and treatment of patients admitted with hyperglycemia.
* During the intervention period, the study team visited the ward daily and guided the medical staff as to the use of the treatment protocol.
* During the post-intervention period, the study team collected the data without active intervention in the implementation of the protocol.
* Data was collected on the mode of treatment and glycemic control of all hyperglycemic patients throughout the study. The incidence of hypoglycemia, complications (myocardial infarction, stroke, infections), mortality, transfer to intensive care unit (ICU), length of hospitalization, and disposition at discharge were noted.


Eligibility Criteria:
Inclusion Criteria:

* All patients admitted to the internal medicine ward with hyperglycemia

Exclusion Criteria:

* Patients admitted due to hypoglycemia, hyperosmolar state, and ketoacidosis
The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients

Sleep problems can lead to a bad quality of life and a raise of morbidity, also in dialysis patients. Sleep problems can be caused by a disturbance of circadian rhythms in our body. For a good regulation of these circadian rhythms a uniform external synchronisation is necessary. This is the synchronisation of the biological clock of our body by light and other influences. In case of a disturbance of the external synchronisation, due to for example naps during the day or wake periods at night, internal rhythms can be unlinked. As a result a weakened melatonin rhythm and a problematic sleep-wake cycle can be observed. Most dialysis patients have sleep problems. Their sleep latency is prolonged. They often take a nap during the day and their sleep efficiency is poor. There has only been one study on the melatonin rhythm of dialysis patients. The conclusion of this study was that the melatonin rhythm of dialysis patients is weakened and disturbed, probably caused by renal insufficiency. In this study no link was made between melatonin rhythm and the nature and severity of possible sleep problems. In different studies with non-dialysis patients and a disturbed melatonin rhythm, exogenous melatonin at the right time leads to a recovery of the normal rhythm and the normal biological clock and a better quality of life.

The aim is to research the endogenous melatonin rhythm and to improve sleep problems of hemodialysis patients with a placebo-controlled study with exogenous melatonin. Next to this a substudy is performed, in which the effect of the change of daytime to nocturnal in hospital hemodialysis on sleep and melatonin is researched.


Eligibility Criteria:
Inclusion Criteria:

* Stable Peritoneal dialysis
* Stable Hemodialysis
* Age 18-85 years

Exclusion Criteria:

* use of hypnotics, MAO inhibitors or neuroleptics
* Liver disease
* Participation in drug investigation \< 1 months to start
* Former use of melatonin
* Severe neurological/psychiatric disease
* Allergic to melatonin or additives
Progressive Exercise After Total Knee Arthroplasty (TKA)

Total knee arthroplasty (TKA) is performed more than 7.000 times a year in Finland most often for osteoarthritis (OA). While pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. Quadriceps weakness has been implicated in the development and progression of knee OA and is a significant problem after TKA. Advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after TKA.

The aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary TKA.

Many studies have shown, that after TKA pain decreased significantly, but muscle strength of the operated knee did not recover and may stay under the preoperative level. To find out the effects of progressive exercise program the investigators will perform, 6 weeks after TKA, a randomized clinical trial of lower extremity strength training using two subgroups of people: traditional exercise group and progressive exercise group.

Eligibility Criteria:
Inclusion Criteria:

* primary unilateral TKA for knee osteoarthritis

Exclusion Criteria:

* Rheumatoid arthritis
* Fibromyalgia
* Bilateral TKA
* Heart or lung disease, which prevent training
* Unstable serious disease (cancer)
* Reduced cooperation (drug, alcohol abuse, mental illness)
Ultrasound for Socket Healing Evaluation

The design is a single blinded, dual comparative study of ultrasound versus micro-CT/LASCA in one study group. Up to a total of 140 subjects registered will be recruited. Subjects who are treatment planned for extraction of a hopeless tooth and socket augmentation with bone graft and are planned for a dental implant surgery. The socket will be evaluated before the extraction and multi-time points during healing until an implant is placed with various evaluation tools, including ultrasound.

The design is a single blinded, dual comparative study of ultrasound versus micro-CT/LASCA in one study group. Up to a total of 140 subjects registered will be recruited. Subjects who are treatment planned for extraction of a hopeless tooth and socket augmentation with bone graft and are planned for a dental implant surgery. Qualified subjects will be asked during their pre-assessment visit. Subjects will be scanned with ultrasound and LASCA among other assessments shown in the info-graph and schedule of events. At the day of tooth extraction and socket augmentation (graft placement), clinical exams/measurements are taken, along with other research activities described in the info-graph and schedule of events. Recovery (checkups) from surgery will be monitored at 2 weeks, 1 month and 2 months, and 3 months. The timepoints additional to normal clinical timepoints are needed to gather potentially diagnostic valuable information about graft maturation, which in the future may lead to an early graft failure decision or trigger other clinical steps such as infection management.

Eligibility Criteria:
Inclusion Criteria:

* Patients at least 18 years of age and have at least a tooth that is considered hopeless, planned for an extraction and a bone grafting procedure for subsequent dental implant surgery.

Exclusion Criteria:

* Patients not willing or not able to have an extraction, bone graft and subsequent implant surgery due to health, finance, or any other reasons.
A Qualitative Study on CSII in Children and Adolescents Having Type 1 Diabetes

Using qualitative method; a qualitative case study using semi-structured interviews to explore patients' experiences. Study population of insulin pump patients aged 11-18 years old will be recruited from pediatrics with T1D at Dasman Diabetes Institute; who started using CSII at least one year ago and their parents. Semi-structured interviews will be recorded and then transcribed word by word. Data analysis will be performed using an inductive thematic approach.

SPECIFIC AIMS

1. To explore the experiences of adolescents and their parents and parents ofi children with type 1 diabetes in Kuwait about the use of Insulin Pump Therapy (IPT) in the context of their quality of life.
2. To gain in-depth understanding of the perceptions of adolescents and their parents and parents of children with type 1 diabetes in Kuwait with T1DM about IPT and its use for diabetes management.

Design A qualitative case study methodology will be adopted using semi-structured interviews for data gathering. Interviews will be conducted with a purposive sample including adolescents and their parents and parents of children with type 1 diabetes in Kuwait with T1D, who are on CSII therapy at least 12 months, along with their parents.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of T1 D in Kuwait as specified by their Consultant and in line with the Kuwait Clinical Guidelines diagnosis of T1D (2006) criteria
* Adolescents between the age of 11 and 18 or children between 2 and 10 years old
* Kuwaiti or expats
* Duration of CSII (Insulin Pump Therapy) at least 12 months.
* Prior to starting Insulin Pump Therapy must have been on MDI for a minimum of 12 months
* Attend the Insulin Pump clinic at DDI

Exclusion Criteria:

* Non-English \& non-Arabic speakers
* Presence of a learning disability
* Diagnosis of any diabetes complication before starting the CSII therapy
* Diagnosis of psychological problem
Satraplatin for Patients With Metastatic Breast Cancer (MBC)

To determine the objective response rate (ORR) of oral satraplatin in patients with Metastatic Breast Cancer.

This is a Phase II open label, nonrandomized study for patients with metastatic breast cancer.

WHAT IS SATRAPLATIN:

Satraplatin is a member of the platinum-based class of chemotherapy drugs. Platinum-based drugs have been clinically proven to be one of the most effective classes of anticancer therapies. Unlike the currently marketed platinum-based drugs, satraplatin can be given orally.

Eligibility Criteria:
1. Has cytologically or pathologically confirmed breast cancer that is metastatic
2. Must have had prior HerceptinÒ therapy if patient has HER2+ (overexpressing) breast cancer. HER2 is considered overexpressed if it is 3+ by IHC or if the gene is amplified by Flourescence in situ hybridization (FISH)
3. Has had no more than 1 prior chemotherapy regimen for MBC
4. Has had no prior platinum-based therapy
5. Has an ECOG Performance Status (PS) 0-2