cyrilzakka/clinical-trials huggingface dataset:
Comparison of Different Acceleration Modes of Transcranial Magnetic Stimulation

To compare the efficacy and safety of 6 times a day, 10 times a day acceleration mode and sham stimulation intervention for TRD, and to explore the antidepressant mechanism of accelerated mode, so as to provide a more simple and effective rapid treatment plan for TRD patients.


Eligibility Criteria:
Inclusion Criteria:

1. The current episode met the DSM-5 diagnostic criteria for major depression, without psychotic symptoms of the first or recurrent drug-free depressive subjects
2. After a full course of treatment with two or more antidepressants, the patient had no response, and the level of treatment resistance was moderate to severe as assessed by the Maudsley staging method

3.24-item Hamilton depression Scale score ≥20

4.The age ranged from 18 to 45 years, both sexes

5.Right handed

6.Written informed consent was obtained and patients volunteered to participate in the study and be evaluated.

Exclusion Criteria:

* 1. Comorbidity with other mental disorders, including schizophrenia, mental retardation, substance dependence, etc.

  2. Suffering from serious or unstable physical diseases

  3, pregnant, lactating women, women of childbearing age screening period urine HCG test results are positive

  4. Subjects with metal objects in the body or other contraindications to MRI scanning

  5. There are other conditions considered by the investigator to be inappropriate for participation in the clinical trial.
A Double-blind, Randomized, Parallel Design Study to Compare the Effectiveness of Sugammadex Versus Neostigmine in Improving Surgical Condition in Subjects Undergoing Laryngeal Microsurgery

Investigators hypothesized that the surgical condition will be improved with the use of sugammadex in patients undergoing laryngeal microsurgery. Investigators will compare the effect of sugammadex and neostigmine on the surgical condition during laryngeal microsurgery.


Eligibility Criteria:
Inclusion Criteria:

* adult patients of age over 20 years
* scheduled for laryngeal microsurgery under general anesthesia

Exclusion Criteria:

* anticipated difficult intubation, cervical spine disease, neuromuscular disease, acute or chronic renal failure, liver cirrhosis or liver failure
* history of allergy to nondepolarizing muscle relaxant
* history of malignant hyperthermia
* pregnant woman
* body mass index over 35 kg/m2
Reduced Total Blood Loss and Blood Transfusion in Non-Septic Revision Knee Arthroplasty Using a Bipolar Sealer

To investigate if the use of a bipolar sealer for skin and capsula incision results in decreased total blood loss and/or less blood transfusion in non-septic knee arthroplasty.

In patients undergoing primary total knee arthroplasty, perioperative anemia is highly prevalent. In a systematic review, preoperative anemia was found in 24 +/- 9% and postoperative anemia in 51% +/- 10%. Perioperative anemia was associated with a blood transfusion rate of 45 +/- 25%, postoperative infections, poorer physical functioning and recovery, and increased length of hospital stay (LOS) and mortality. Although the best transfusion trigger in elective patients remains unknown, restrictive transfusion protocols are recommended and avoidance of blood transfusion if possible.

The only non-systemic modality capable of reducing blood loss before it occurs is a bipolar sealer (Aquamantys). By pre-incisional treatment of the soft tissue, bleeding (and potentially total blood loss and transfusion) is reduced without tissue charring.

Previously studies on the use of Aquamantys in primary knee arthroplasty have had various outcomes, the most recent being negative while the former 3 were positive regarding reduction in blood loss, drop in hgb and transfusions. No published date exist on potential outcomes in revision knee arthroplasty where blood loss and transfusion needs exceeds that of primary total knee arthroplasty by far. Aquamantys hence would theoretically benefit the most in a revision setting without the use of a tourniquet - and would be an interesting modality in modern contemporary fast-track revision if shown effective despite/on top of the use of additional blood saving modalities. The present study is therefore motivated by investigating this aspect.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing Non septic knee-arthroplasty revision.
* Musk speak and understand Danish

Exclusion Criteria:

* Age below 18.
Radiofrequency Ablation in Resectable Colorectal Lung Metastasis

Lung metastasectomy is the only therapeutic option to provide a long-survival in patients with colorectal lung metastases. Recent studies have shown that radiofrequency (RF) ablation is a safe and useful therapeutic option for the treatment of unresectable lung metastases. In this phase-II trial, clinical utility of lung RF ablation will be evaluated in patients with resectable colorectal lung metastases.

This will be a phase-II clinical trial.

Lung metastasectomy is the only therapeutic option to provide a long-survival in patients with colorectal lung metastases. Recent studies have shown that radiofrequency (RF) ablation is a safe and useful therapeutic option for the treatment of unresectable lung metastases. In this clinical trial, clinical utility of lung RF ablation will be evaluated.

Patients with resectable lung metastases will receive lung RF ablation.

All subjects will be followed for overall survival, safety, change in respiratory function, cancer-specific survival, and local tumor progression.

Eligibility Criteria:
Inclusion Criteria:

* Primary lesions (colorectal cancer) are resected.
* Lung metastases appear.
* No extrapulmonary metastases or after locoregional treatments.
* Lung metastasis is considered to be controllable either by metastasectomy or radiofrequency (RF) ablation.
* Five or less lung metastases measuring 3cm or smaller.
* PET study within 8 weeks before metastasectomy or RF ablation.
* White blood count of 3000/mm3 or more.
* Platelet count of 100,000/mm3 or more.
* Hemoglobin level of 8.0 g/dl.
* Serum creatinine level of 2.0 mg/dl or less.
* PaO2 of 70 mm Hg or more（Room air）or SpO2 of 93%.
* Serum bilirubin level of 2.0 mg/dl or less.
* Performance status of 0 or 1.
* Expected survival of 1 year or more.
* Age of 20 years or more.
* Informed consent from the patient.

Exclusion Criteria:

* Risk to injure lung vessels 5 mm or larger.
* Lung metastases adjacent to the heart, trachea, esophagus, and aorta.
* Association of uncontrollable malignancies.
* Lung hilar lymph node metastasis.
* One lung.
* Pulmonary hypertension.
* Coagulopathy.
* Impossible to stop using anticoagulants.
* Active infection or C-reactive protein of 3 or higher.
* Association of active inflammation.
* Fever (higher than 38 degrees celsius).
* Previous external-beam radiotherapy for the treated lung.
* Pregnant.
* Judgment to be an inappropriate candidate by a attending physician.
The Project of Gestational Hypertension and Preeclampsia Screening and Prevention Center

Preeclampsia is the main cause of illness and death in pregnant women and fetuses. Currently, there is no effective treatment for preeclampsia in clinical practice, and the fundamental treatment is still termination of pregnancy and placental delivery.

Therefore, early prediction of preeclampsia and targeted strengthening of high-risk pregnant women supervision, early intervention and diagnosis and treatment can greatly reduce the serious obstetric complications and perinatal maternal and fetal deaths caused by preeclampsia, which has significant social and clinical significance.

The purpose of this study is to evaluate the influence of pre-eclampsia risk screening scheme based on maternal high-risk factors or pre-eclampsia risk assessment and management plan based on placental growth factor (PIGF) detection in the real medical world on the incidence of pre-eclampsia, maternal mortality and severe complications of pre-eclampsia, and to establish appropriate pre-eclampsia risk screening and prevention standards and guidelines for China population, so as to reduce the probability of maternal and fetal death and long-term chronic diseases.

Eligibility Criteria:
Inclusion Criteria:

* 1) Pregnant women who have been screened for pre-eclampsia risk according to the clinical risk factors listed in NICE guidelines (2019);
* 2) Based on the authoritative guideline of Figo and the consensus of experts in China, pregnant women who routinely use maternal factor +MAP＋PLGF±UtA-PI in the first trimester or PLGF or sFlt-1/PLGF in the second and third trimesters to assess the risk of preeclampsia.
* 3) Meet any of the above conditions, join the group voluntarily, and sign the informed consent form.

Exclusion Criteria:

* 1) Severe fetal malformation or abnormality (no fetal heartbeat);
* 2) Those who regularly use aspirin before joining the group;
* 3) There are obvious other abnormal signs, laboratory tests or other clinical d• iseases, which are judged by the researcher to be not suitable for participating in researchers;
* 4) Unable to obtain follow-up and delivery information.
An Observational Clinical Study Plan on the Effects of Radiotherapy on the Immune System of Patients With Malignant Tumors.

To explore the impact of radiotherapy on peripheral blood myeloid-derived suppressor cells (MDSCs), T cells and extramedullary erythroid precursor cells in patients with malignant tumors, and to evaluate the correlation between changes in the proportion of these cells before and after radiotherapy and the efficacy of radiotherapy in patients.

To clarify the impact of radiotherapy (and/or other treatment combinations) on the proportion of myeloid-derived suppressor cells (MDSCs), T cells and extramedullary erythroid precursor cells in the peripheral blood of patients with malignant tumors, and to evaluate the changes in the proportion of these cells before and after radiotherapy and the relationship between the patients Correlation with the efficacy of radiotherapy. On this basis, it provides theoretical guidance for the determination of new clinical treatment plans.

Eligibility Criteria:
Inclusion Criteria:

1. Over 18 years old, diagnosed with breast cancer, nasopharyngeal cancer, colorectal cancer, cervical cancer, lung cancer, head and neck cancer and requiring radiotherapy, and the above malignant tumors have not metastasized.
2. Complete inspection information.
3. No other serious complications.
4. No infectious diseases.
5. Able and willing to take blood tests.
6. All researchers gave informed consent and signed an informed consent form, which complied with the requirements of the Medical Ethics Committee.

Exclusion Criteria:

1. People with mental illness.
2. People with autoimmune system diseases.
3. Those combined with serious diseases of other organs.
4. Those with severe alcoholism and drug abuse.
5. Research subjects who voluntarily withdraw from the study.
Efficacy and Safety of 6 Months Treatment With Paricalcitol Injection or Oral in Patients With Secondary Hyperparathyroidism on Dialysis

Prospective, non-randomized, multi-center study to assess the efficacy and safety of paricalcitol injection or oral administered over 6 months to patients with secondary hyperparathyroidism on dialysis.


Eligibility Criteria:
Inclusion Criteria:

* Patients \>=18 years with secondary hyperparathyroidism (iPTH \>= 300 pg/mL)
* Patients in a chronic hemodialysis or peritoneal dialysis program previously treated with vitamin D metabolites or without previous treatment
* Patients in which treatment with paricalcitol injection or oral is clinically indicated according to the criteria of the participating investigator
* Patients providing their signed informed consent to participate in the trial

Exclusion Criteria:

* Patients with severe hyperparathyroidism (iPTH \> 3,000 pg/ml)
* Patients with hypercalcaemia (calcium \>=11.0 mg/dl, adjusted according to Albumin level), hyperphosphataemia (phosphorus \>= 6.5 mg/dl) or patients with calcium x phosphorus \>= 70
* Known hypersensitivity and/or toxicity to vitamin D metabolites and/or other product ingredients
* Patients who have participated in clinical studies within the last month or who are currently enrolled in clinical studies
* Patients who cannot tolerate or take phosphorus binders that do not contain Calcium and/or Aluminum
* Patients that in the opinion of the investigator, for any reason, are not good candidates for therapy with Synthetic Analogues of Vitamin D
Endoscopic Treatment for Isolated, Single Suture Craniosynostosis

This is a prospective study to evaluate outcomes in patients undergoing endoscopic craniectomy for isolated, single-suture craniosynostosis.


Eligibility Criteria:
Inclusion Criteria:

* Infants 1 to 6 months of age with isolated, single-suture craniosynostosis.

Exclusion Criteria:

* Multiple suture craniosynostosis and infants older than 6 months of age.
AQP-1 Polymorphism on Fluid Status in Hemodialysis Patients

It is a cross sectional observational study. It is to investigate whether AQP-1 polymorphism has any impact on fluid status in hemodialysis patients. The long term stable HD patients in the current center will be enrolled to the study after informed consent. Blood samples will be collected for gene-typing. Fluid status including blood pressure, weekly UF and intra-dialysis body weight change will be collected through their clinical records.


Eligibility Criteria:
Inclusion Criteria:

* age 18-70
* ESRD
* maintained HD
* no target weight change during the last week of entering the study and achieve target weight at the end of HD section
* informed consented

Exclusion Criteria:

* expected survival time less than 3 months
Screening and Prevalence of Adolescent Idiopathic Scoliosis in Selected Urban and Countryside Schools in Egypt

Early detection of scoliosis and determination of which areas are more affected urban or countryside will help in early management. Also, this will guide the government and the community for early intervention to decrease the factors that leads to this postural abnormality. This also will guide another clinician to search for the cause of these posture deformities and to concentrate screening for special areas with special cultures.

Scoliosis may have an impact on the Egyptian society as children between 10-15 years old represent 9.5 % of the population which is the third large category appendix (3). So without the early detection of adolescent idiopathic scoliosis for that age group, bad impacts will be implemented for Egyptian society by causing disabilities and psychological problems for these children.

The early detection of scoliosis is of a great importance as curve detection before skeletal maturation gives a good opportunity for early treatment or prevention of curve progression. Scoliosis has a bad effect on cosmetic appearance, quality of life, Psychological well-being, disability, back Pain, breathing function. It may also progress in adulthood and need further treatment. So a multidimensional and comprehensive evaluation of scoliosis patients is necessary to design a complete therapeutic approach.

Eligibility Criteria:
Inclusion criteria:

1. Age range from 10 to 15 years.
2. Males students.
3. Students who have structural scoliosis.

Exclusion criteria:

1. Congenital deformities.
2. Recent fracture and there is a fixation in the upper or the lower extremities
3. Neuromuscular disorder (Cerebral palsy and spinal muscle atrophy).
4. Syndromic disorders (Muscular dystrophy, Osteogenesis imperfect, and Spina-bifida).
Effectiveness of a Community Health Worker Delivered Care Intervention for Hypertension Control in Uganda

Over 80% of the morbidity and mortality related to non-communicable diseases (NCDs) occurs in low-income and middle-income countries (LMICs). Community health workers (CHWs) may improve disease control and medication adherence among patients with NCDs in LMICs, but data are scarce, particularly in sub-Saharan African settings. In Uganda, and the majority of LMICs, management of uncontrolled blood pressure remains limited in constrained health systems. Intervening at the primary care level, using CHWs to improve medical treatment outcomes has not been well studied. The investigators aim to determine the effectiveness of a CHW-led intervention in blood pressure control among confirmed hypertensive patients and patient-related factors associated with uncontrolled hypertension. Methods: Conduction of a stepped-wedge cluster randomized controlled trial study of 869 adult patients with hypertension attending two NCD clinics to test the effectiveness, acceptability and fidelity of a CHW-led intervention. The multi-component intervention will be centered on monthly household visits by trained CHWs for a period of seven months, consisting of the following; (1) blood pressure and sugar monitoring; (2) BMI monitoring; (3) cardiovascular disease risk assessment; (4) Using checklists to guide monitoring and referral to clinics; (5) healthy lifestyle counselling and education. During home visits, CHWs will remind patients of follow-up visits. The investigators will measure blood pressure at baseline and 3-monthly for the entire cohort. The investigators will additionally test acceptability of the intervention and fidelity over the course of the intervention. The investigators will conduct individual-level mixed effects analyses of study data, adjusting for time and clustering by patient and community. Conclusion: The results of this study will inform community delivered hypertension management across a range of LMIC settings.


Eligibility Criteria:
Inclusion Criteria:

* Participants with hypertension (Systolic \>140 and/or Diastolic \>90)
* Participants attending the two NCD clinics
* Adults 18 years and above
* Participants residing in the three sub counties (Nakaseke Town Council, Nakaseke Sub County and Kasangombe of Nakaseke district)
* Participants able to give informed consent.

Exclusion Criteria:

* Patients diagnosed with hypertension but already controlled
* Pregnant women
* Patients with an expected life expectancy of less than one year
Near Infrared Fluorescence Imaging With Indocyanine Green

This research study will evaluate how Near Infrared Fluorescence imaging (NIFI) with indocyanine green (ICG) contrast dye can assist in the identification and diagnosis of lung nodules during surgery. NIFI is an intraoperative imaging technology that utilizes a coupled camera/fluorophore (ICG) system to fluoresce tissues of interest. Intravenous ICG is a fluorophore with a long-standing high safety profile.

This research study is a pilot test of the effectiveness of a near infrared fluorescence imaging (NIFI) system in the detection and diagnosis of pulmonary nodules. Patients selected for enrollment in this study will be adults (≥18 years) that have been scheduled for surgical biopsy and/or resection of a primary lung nodule identified by prior imaging. Patients will receive an injection of indocyanine green (ICG) contrast dye one day prior to their surgery. Intraoperatively, the NIFI system will be used to visualize and characterize the fluorescence patterns given off by these lung nodules, as well as look for additional undiagnosed nodules. These nodules will then be resected and receive histological characterization, as per standard of care. The NIFI system will be evaluated for its ability to 1) visualize nodules and their margins 2) differentiate between benign and malignant nodules and 3) identify additional undiagnosed nodules.

Eligibility Criteria:
Inclusion Criteria:

* Subjects must be willing to undergo surgical biopsy and/or resection of pulmonary nodule(s).
* Women and men at least 18 years of age
* Subjects must have a CT scan of the chest within 8 weeks of surgery

Exclusion Criteria:

* Previous thoracic surgery
* Inoperable tumor/nodule
* Unable to tolerate surgery
* History of allergies to iodides
* Breast feeding
* Pregnant
Conservative vs Surgical Treatment for Proximal Humerus Fractures in the Elderly

This is a randomized trial comparing conservative with surgical treatment (with open reduction and locking plate fixation) for proximal humeral fractures in patients aged more than 60 years.

Different methods have been used in the treatment of proximal humeral fractures. Usually, treatment choice depends on fracture displacement, patient age, osteoporosis, and other characteristics. Locking plate fixation has become the most widely used method among surgical techniques, while partial arthroplasty is reserved for older patients and comminuted articular fractures. Generally, nonsurgical treatment involves a brief period with sling immobilization and physiotherapy rehabilitation.

A recent multicenter study showed no difference between conservative and surgical treatments, including internal fixation with locking plates. Two other randomized studies showed mixed results, with no relevant clinical differences between the methods. No previous trial has evaluated the quality of reduction in surgically treated fractures and its relation to outcomes. Our study aims to compare both techniques with a detailed radiographic and tomographic evaluation, in elderly patients. We also aim to evaluate the influence of reduction and plate positioning on clinical outcomes. This is a single center trial, in which surgeries will be performed by only two experienced surgeons.

Eligibility Criteria:
Inclusion Criteria:

* Proximal humeral fractures, involving humeral head, with at least one of the following parameters:
* Head-shaft angle between 100-200° or \>175° on coronal plane;
* Shaft translation (on coronal or sagittal plane) \> 1cm;
* Tuberosity displacement \> 0,5cm;
* Head shaft angulation \>45° in axial or sagittal plane;
* Less then 30 days

Exclusion Criteria:

* No contact between shaft and humeral head
* Head-shaft angle \<100° on coronal plane
* Articular head fracture with displacement \> 2mm
* Fracture-dislocation
* Bilateral fracture
* Open fracture
* Ipsilateral or contralateral superior limb fracture
* Pathological fracture (tumors or bone disease, except for osteoporosis)
* Previous rotator cuff complete tear
* Previous infection
* Neurological injury
* Previous shoulder surgery
* Inability to answer subjective scores
Virtual Reality Distraction During Phlebotomy in Children

This randomized controlled study was conducted to evaluate the effect of distraction methods using virtual reality on the emotional appearance, pain, fear, and anxiety associated with the procedure during phlebotomy in children aged 6-12 in a private blood collection unit.

The data of the study was collected with Socio-demographic Data Collection Form, Emotional Appearance Scale for Children, Facial Expression Rating Scale, Child Anxiety Scale-State, and Child Fear Scale. Demographic data and mean scores obtained from the scales were compared between the virtual reality groups, and the control group.

Eligibility Criteria:
Inclusion Criteria:

* The child agrees to participate in the study voluntarily.
* The parent agrees to participate in the study voluntarily.
* Obtaining consent forms from the child and parent

Exclusion Criteria:

* The child has a physical and psychological deficit that will prevent him from wearing the glasses that will be placed on his head to watch virtual reality.
* Having fever (\>37.5C) and severe dehydration
* The patient did not take analgesics before the intervention