cyrilzakka/clinical-trials huggingface dataset:
Retroperıtoneal Soft-Tıssue Sarcomas

: Soft Tissue Sarcomas are rare mesenchymal tumors with many subtypes. Clean margin-wide resection is recommended for treatment. The guidelines recommend that sarcoma treatments be carried out in sarcoma centers. In this study, the location, histopathological features, clinical and demographic features, recurrence, and prognosis of retroperitoneal sarcomas were investigated.

The demographic, histopathological, and immunohistochemical data of the patients who were operated on with the diagnosis of intraabdominal mass at Istanbul Medeniyet University Göztepe Prof. Dr. Süleyman Yalçın City Hospital from March 2016 to December 2020 were retrospectively evaluated. Ethical approval was obtained from Istanbul Medeniyet University Göztepe Prof. Dr. Süleyman Yalçın City Hospital Ethics Committee.

Patients diagnosed with pathological sarcoma subclass were included in the study. Patients younger than 18 years were excluded from the study. Visceral organ-origin sarcomas and extremity sarcomas were also excluded from the study. GIST's were included in sarcoma subtypes by WHO in 2013. However, they were not included in the study due to their solid organ origin.

The data of 18 patients' whore remained after the exclusion criteria were analyzed retrospectively. Pathology samples of the patients were re-examined by a single pathologist.

The demographic analysis was used for statistics.

Eligibility Criteria:
Inclusion Criteria:

* Patients operated with the diagnosis of intra-abdominal mass
* patients diagnosed with pathological sarcoma subclasses

Exclusion Criteria:

* Patients younger than 18 years
* Visceral organ-origin sarcomas
* extremity sarcomas
* GIST
Normal Range of Measurement of Lumbar Spinal Canal in MSCT

The present study aims to establish a normal range of measurements of lumbar spinal canal.

The knowledge of normal diameter of lumbar spinal canal is very important for diagnosing lumbar spinal canal stenosis and also for performing spinal surgeries at the lumbar level by Neurosurgeons and Orthopedicians. However, it varies widely among ethnic groups and between sexes in the same ethnic group . Spinal canal stenosis (defined as the narrowing of central spinal canal) is a condition in which the anteroposterior (AP) and lateral dimensions of the bony spinal canal are less than normal for corresponding age and sex. Back pain is the commonest manifestation of lumbar canal stenosis which usually results from lumbar spondylosis. Lumber lordosis is a problem of adults, but is now being increasingly seen in youth, probably due to lifestyle changes. Multiple factors play a role in spondylosis, but if it is associated with spinal canal stenosis, its management differs. Radiological evaluation forms an important part in the evaluation and management of lumbar spondylosis. But it requires clear understanding of the normal dimensions of lumbar vertebrae for particular age \& sex . Multislice computed tomography (MSCT) scans provides a noninvasive, non-operator dependent method of direct imaging of the spinal canal without injection of intra thecal contrast and is better than MRI for bony detail as in osteophytes. Though there is a wide variation in the capacity of spinal canal in patients who are clinically and radiologically normal. It is said that those with smaller canals are more likely to have symptoms from nerve root compression . By determining normal ranges of spinal canal diameter investigators can make early diagnosis in individuals who have lower diameters of spinal canal. These individuals are predisposed to spinal canal stenosis, which is a major cause of spinal radiculopathies. The recent use of CT for the measurements of the vertebral dimensions such as canal diameter and vertebral dimension has led to better evaluation of vertebral morphometry as compared with x-ray and cadaveric studies . CT scan measurement of lumbar spine demonstrated a mean AP canal diameter between 12 mm and 14 mm with a measurement of 11.5 mm considered small. On CT scan, electronic measurement of the sagittal diameter of the normal bony canal is 11.5 mm . These differences in dimension of the spinal canal across studies demands necessity of study of dimension of the spinal canal in every ethnic group.

Eligibility Criteria:
Inclusion Criteria:

* Normal population without any known vertebral column pathology or complaints in both sex \& different age groups.
* Patient fit for CT examination.

Exclusion Criteria:

* Pregnancy.
* Patients having sciatic pain with or without pain in the back.
* Patient having past history of back surgery.
* Patients with osteophytes or developmental anomalies, trauma vertebral fracture and known case of lordosis, scoliosis or kyphosis or other abnormalities in lumbar vertebrae.
Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer

To investigate the levels of Relaxin in different types of endometrial preparation for a frozen embryo transfer cycle. Up to now it is unclear, whether ovulation with a functional corpus luteum (CL) will be present in a natural proliferative phase (NPP) endometrial preparation approach.

The last years have seen a distinct shift from fresh (fresh ET) to frozen embryo transfer (FET) cycles. Furthermore it became obvious, that the endometrial preparation approach has a significant impact on the course of the pregnancy and that a HRT endometrial preparation approach is associated with a higher risk for bleeding and miscarriages in early pregnancy and for the development of pregnancy induced hypertension and pre-eclampsia later in pregnancy.

These conditions are attributed to the absence of a CL in the HRT approach. Lately a new endometrial preparation approach is discussed and performed, the so called natural proliferative phase protocol, in which the follicle growth is monitored and when the lining is deemed to have a sufficient thickness and the triple lining pattern, exogeneous progesterone is started to induce secretory transformation before spontaneous ovulation. Despite some studies showing, that exogeneous progesterone administration might induce ovulation, it is not clear whether there will be a CL, producing Relaxin, in the NPP approach.

Eligibility Criteria:
Inclusion Criteria:

* regular menstrual cycles

Exclusion Criteria:

* abnormal findings of the ovaries (e.g endometriosis)
* Intake of any hormones within 3 months of study start
* desire to become pregnant
Comparison of NEOVIST 370 INJ.(Iopromide 768.86mg) With Ultravist 370 INJ.(Iopromide 768.86mg) in Abdominal CT

Comparison of NEOVIST 370 INJ.(Iopromide 768.86mg) with Ultravist 370 INJ.(Iopromide 768.86mg) in abdominal CT


Eligibility Criteria:
Inclusion Criteria:

* Aged 20 to 75 years old.
* Subjects who need CT scan
* Subjects who are willing to participate in the study and to write the informed consent form.

Exclusion Criteria:

* Subjects with severe hepatopathy whose AST or ALT ≥ 1,000 IU/L, Subjects with liver cirrhosis whose AST or ALT ≥ UNL(upper normal limit) X 3
* Severe disorder of thyroid gland
* homocystinuria
* pregnant or breastfeeding female subjects, or female subjects with childbearing potential who are not willing to use proper contraception methods
* Participation in another clinical trial within 30days of enrollment into this study.
The Effect of Hypno-breastfeeding and Solution-oriented Approach

Motivation, which is also necessary for the breastfeeding behavior of mothers in the postpartum period, can affect the success and continuity of breastfeeding. This study was conducted to evaluate the effects of hypno-breastfeeding and solution-oriented approach on breastfeeding motivation and insufficient milk perception in mothers. It is a randomized controlled experimental study. The sample of the study consisted of 90 women who met the inclusion criteria, three groups as the hypno-breastfeeding group, the solution-focused approach group and the control group.

Hypno-breastfeeding, which is a mind-body program that helps to increase breast milk production, is a therapy that includes emotion control, pain management, and positive suggestions that define the mother's role in the breastfeeding process. This method, in comfortable, calm and natural conditions, is effective in increasing the amount of milk by eliminating phobias, anxiety and negative thoughts in the mind of the mother, relaxing and concentrating on breastfeeding. The solution-oriented approach, on the other hand, is a therapeutic counseling practice that does not deal with the problem itself, but focuses on the past successes of the individual and the times when they did not experience the problem. In solution-oriented approach, which argues that each individual can solve their problems with their own internal resources by only directing them to the positive, it focuses on the strengths of the person instead of underlining the weaknesses. No study has been found on the effect of solution-oriented approach on breastfeeding process in the perinatal period. However, there are studies that show that the application of solution-oriented approach, which will make a different contribution to midwifery philosophies, is effective in reducing the fear of birth and reducing the anxiety of mothers who have anxiety about premature baby care. It is thought that with the effective use of the hypno-breastfeeding method and solution-oriented approach by midwives and health personnel, the perception of insufficient milk of mothers during the breastfeeding process can be reduced and breastfeeding motivation will be positively affected. In this context, this study aimed to determine the effect of hypno-breastfeeding and solution-oriented approach on breastfeeding motivation and insufficient milk perception.

Eligibility Criteria:
Inclusion Criteria:

* Single pregnancy
* 35 weeks and above healthy pregnancy
* No communication barrier
* No diagnosed psychiatric problem
* Normal delivery
* No complications of mother and baby

Exclusion Criteria:

* Multiple pregnancy
* 34 weeks and below pregnancy
* Communication barrier
* Clinical diagnosis of psychiatric problem
* Cesarean delivery
* Complications in mother and baby
Study of Anatomic Nerve Sparing Radical Perineal Prostatectomy

Our objective is to evaluate the clinical outcomes for the anatomic radical perineal prostatectomy (RPP) for the surgical management of prostate cancer. We will report the perioperative, oncologic, and functional outcomes in patients undergoing the radical perineal prostatectomy at our institution.

The purpose of our study is to evaluate perioperative, oncologic, and functional outcomes for the anatomic radical perineal prostatectomy. The anatomic radical perineal prostatectomy is standard-of-care surgical approach to the surgical management of localized prostate cancer. The operative technique selected for radical prostatectomy is largely based on patient preference after appropriate counseling, and surgeon recommendation based on surgical considerations and surgeon experience. Outcome data for the anatomic radical perineal prostatectomy will represent a valuable addition to the published body of literature. Our study is a prospective clinical outcome data collection and analysis and we will be looking at data within several domains. First, perioperative data will be collected to evaluate the OR time, blood loss, surgical complications, and length of hospital stay for the anatomic radical perineal prostatectomy. Second, oncologic efficacy of this procedure will be reported, based on margin status of surgical specimens, which will be correlated with tumor features (Gleason score, tumor volume, pre-op PSA score). Third, functional outcomes will be evaluated by comparing urinary, sexual, and bowel function in the pre-op and post-op settings. This third domain will be accomplished by employing the following validated questionnaires (attached - SHIM, IPSS, and EPIC-26). These questionnaires will be filled out at 3 time-points: pre-op, and at 3 months and 12 months post-operatively.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age
* Perineal prostatectomy for prostate cancer at Maimonides Medical Center

Exclusion Criteria:

* Dementia
Influence of Working Length Methods in the Performance of Pulpectomies in Primary Teeth

Verify, through a randomized double-blinded clinical trial, the influence in the performance of pulpectomies in primary teeth, based on two working length methods, electronic and radiographic.

Samples will be composed of children between 6 and 9 years of age, with the need for endodontic treatment in primary teeth. They will be submitted to anamnesis, clinical and radiographic exams for identification of eligibility criteria for the study. These patients will be divided randomly into 2 groups: G1 - pulpectomy with working length method performed through radiography (n=100) and G2 - pulpectomy with working length method performed with the aid of an apex locator (n=100). Endodontic treatment will be done by a single trained operator. After definite restoration and final radiography, an evaluation of the obturation quality will be performed by another blinded operator, who will evaluate the appropriate obturation length. The clinical treatment success and the radiographies will also be analyzed during a period of 24 months through clinical and radiographic exams, also by a blinded operator.

Eligibility Criteria:
Inclusion Criteria:

* Primary molars teeth with caries or defected restorations associated with signs or symptoms of irreversible pulpal inflammation - spontaneous pain or pulpal necrosis - presence of abscess, fistula, edema, periapical or inter-radicular radiolucency

Exclusion Criteria:

* Primary molars teeth previously manipulated, with obliteration of the root canal, with bone reabsorption involving the crypt of the permanent tooth, internal or external pathological or physiological reabsorption involving more then half of the shortest root and unrestorable tooth
Impact of Virtual Reality Hypno-sedation on Functional Recovery and Anxiety in Foot Surgery With Regional Anesthesia

This prospective study aims to evaluate whether the implementation of a virtual reality hypnosedation (VRH)protocol reduces preoperative anxiety and increases patient comfort before, during, and after outpatient foot surgery.

This prospective study aims to evaluate whether the implementation of a virtual reality hypnosedation (VRH) protocol reduces preoperative anxiety and increases patient comfort before, during, and after outpatient foot surgery. The investigators hope to demonstrate a reduction in anxiety, improved postoperative experience and functional recovery according to currently validated scores measuring preoperative and postoperative recovery, anxiety and stress, and experience during a regional anesthesia technique.

The investigators expect that VRH will be more effective than VR alone and conventional pharmacological sedation in reducing preoperative anxiety and in improving experience and functional recovery. If the hypothesis is correct, the investigators could propose to integrate this protocol as a first line in the ambulatory management of elective foot surgery.

Eligibility Criteria:
Inclusion Criteria:

* Major patients, classified as ASA 1-2-3, admitted for foot surgery (metatarsophalangeal arthrodesis or hallux valgus cure), under peripheral locoregional anesthesia (sciatic nerve block at popliteal level).

Exclusion Criteria:

* pregnant women
* patients with peripheral neuropathy or other severe neurological pathology
* allergy or contraindication to local anesthetics or benzodiazepines
* chronic renal failure or severe hepatic failure
* major hemostasis disorders
* severe vision or hearing problems that would render the VR and VRH device useless or unusable, and patient contraindication or refusal to use the VRH headset, such as claustrophobia or kinesiophobia.
Efficacy of Self Vs. Physician Application of Triamcinolone-Econazole in Otomycosis

to analyze the clinical characteristics, types of Fungal Infections, and comparison of the efficacy of patient self-application versus physician application of triamcinolone acetonide econazole cream in otomycosis treatment.

The study analyzes the clinical characteristics, including symptoms and physical examinations, as well as the types of fungal infections. It compares the efficacy of patient self-application versus physician application of triamcinolone acetonide econazole cream in treating otomycosis two weeks after starting treatment. Furthermore, the study also compares the recurrence rates six months after treatment.

Eligibility Criteria:
Inclusion Criteria:

* 1.The chief complaint was ear discomfort, including tinnitus, a feeling of blockage or fullness, pruritis, otalgia, otorrhea and decreased hearing; 2. Physical examination findings:presence of fungal hyphae or accumulations that appear creamy or cheese-like or resembling abnormal earwax (crusts, films) , skin redness, erosion, swelling, or granulation tissue within the ear canal; 3. Positive results in fungal culture.

Exclusion Criteria:

* The exclusion criteria included otitis media, tympanic membrane perforation, and conditions post-radiotherapy.
Minor Traumatic Brain Injury : MRI Examination of Consequences and Social Insertion

Minor traumatic brain injury (mTBI) (Glasgow Coma Scale 13 to 15) represent 70 to 90% of traumatic brain injury. Different disorders may occur after a traumatic minor brain injury (somatic, cognitive or affective) within 2 weeks.

For 10 to 20% these symptoms are persistent and are part of post-concussion syndrome. Today a small amount of tools to predict this syndrome are available. Cerebral CT scan, a routine test for mTBI, isn't relevant to predict the post concussion syndrome.

In order to improve understanding of the evolution toward this complication, it seems relevant to run a multimodal study.

Multiparameter MRI combined to psychological and sociological evaluations cold provide a better global perception.


Eligibility Criteria:
Inclusion Criteria:

* Patients who answered to psychological questionnaires 3 month after mTBI
* Patients with mTBI according to European Federation of Neurological Societies
* Initial CT scan indication according to 2012 French Society of Emergency Medicine and European Federation of Neurological Societies
* Health insurance
* Written consent

Exclusion Criteria:

* Under 18 years
* Psychiatric or neurologic history with long term treatment
* Hospitalization due to extra-cranial wounds or intoxication (except alcool)
* MTBI due to aggression
* MRI contraindication
* Inability to understand french language
* Pregnant or breastfeeding women
* Incapacitated patients in accordance with article L 1121-5 to L1121-8 of the public health code
* Patients in another study's exclusion time
* Inability to have a follow-up
* Patients who can't be reached in case of emergency
MECKI-Amyloidosis: Assessment of the Exercise Capacity and Prognosis of Patients with Cardiac Amyloidosis

This study aims to advance the understanding of cardiac amyloidosis, its effects on exercise capacity, and its prognostic implications. By conducting a systematic investigation with particular emphasis on longitudinal evaluation, we aim to provide valuable insights to guide clinical practice and improve the management of patients with cardiac amyloidosis.

Our study intends to follow patients for a period of two years, evaluating them every six months. This longitudinal approach allows us to monitor changes in exercise capacity and other relevant clinical parameters over time. Furthermore, it enables the development of a prognostic tool similar to the MECKI score, capable of assessing the risk of adverse events in patients with cardiac amyloidosis based on their exercise performance.

By comparing our results with data from heart failure patients already included in the MECKI score database, we also aim to highlight any differences in prognosis between patients with cardiac amyloidosis and those with general heart failure. Finally, we aim to characterize cardiac amyloidosis by differentiating it from general heart failure. By comparing our results with data from heart failure patients already included in the MECKI score database, we can clarify the distinct exercise limitations in cardiac amyloidosis and shed light on how they differ from more conventional heart failure.


Eligibility Criteria:
Inclusion criteria

* Age \> 18 years
* Diagnosis of cardiac amyloidosis obtained by MRI or scintigraphy
* Ability to perform a cardiopulmonary exercise test

Exclusion criteria

* severe obstructive pulmonary disease
* exercise-induced angina
* significant ECG changes
* presence of clinical comorbidities that interfere with exercise performance
Custom Molded Foot Orthoses Effect on Foot Kinematics and Lower Extremity Electromyography During Walking and Running.

The purpose of this study was to determine the effectiveness of two types of in-shoe custom made orthotics in altering the motion of the foot and muscle activity of select muscles of the lower leg in individuals experiencing lower extremity symptoms of a non traumatic origin. We hypothesized that orthotics would decrease the extent of motion of the during walking and running when compared to a barefoot condition. The investigators further hypothesized that orthotics would decrease the amount of muscle activity seen during walking and running when compared to barefoot walking.


Eligibility Criteria:
Inclusion Criteria:

* Subjects must have complaints of lower extremity or foot pain of a non-traumatic, mechanical origin.
* Subjects must have at least 60 degrees of frontal plane forefoot on rearfoot passive range of motion (as determined by a modified Gib test in the symptomatic lower extremity.
* Subjects must be able to walk independently on a treadmill at a speed of 4.8 kmh.
* Subjects must have been referred by a health care professional for an orthosis fitting.

Exclusion Criteria:

* Subjects having less than 60 degrees of forefoot on rearfoot frontal plane passive range of motion.
* Subjects having a history of a fracture of the foot or ankle.
* Subjects having any previous illness, surgery or other characteristic (e.g., cardiovascular, musculoskeletal or neuromuscular problems) that would affect their lower extremity function or ability to walk independently.
* Subjects having knee, lower leg or foot pain of a non-mechanical nature.