cyrilzakka/clinical-trials huggingface dataset:
Peri-conception Key Nutritional Factors and Congenital Heart Disease

The study is a nested case-control study and the purpose is to describe the status of key nutrients(eg.folic acid and vitamins) supplementation among pregnant women in Shanghai, to find out the association between the level of serum key nutrients during peri-conceptional period and the incidence of congenital heart defects (CHD) in newborn, and to provide better preconception care.

Congenital heart defects (CHD) are among the most common major congenital anomalies with an incidence of about 8-12/1,000 live births worldwide. The mechanism of CHD is still unclear. Many studies indicated that the level of key nutrients (eg.folic acid and vitamins) during peri-conceptional period might affect the incidence of CHD, but the evidence is limited. The study aimed to explore the association between serum key nutrients during peri-conceptional period and the incidence of CHD in newborn. All couples attending pre-pregnancy physical examination from 11 districts (Minhang District, Huangpu District, Xuhui District, Changning District, Jingan District, Putuo District, Yangpu District, Jiading District, Pudong District，Songjiang District, Qingpu District) in Shanghai from March 2016, are recruited and their blood samples and questionnaires about the supplementation of key nutrients are collected. During the gestation, venous blood of pregnant women at all of three trimesters is taken. Besides, questionnaires about the supplementation of key nutrients at the first antenatal visit are also obtained. The level of serum folic acid, vitamin A and vitamin B12 at preconception and during gestation are measured. Finally, investigators identifies those whose newborns developed CHD during follow-up as the cases. Then, investigators selects four controls for each case from the rest of the cohort by matching on constitutional determinants of CHD such as age and sex. Participants are identified by national identification number during the follow up. The level of serum key nutrients is compared in cases and controls. Univariate and multivariate association analyses will be performed to identify risk factors to CHD by using multivariate logistic regression model.

Eligibility Criteria:
Inclusion Criteria:

* attend pre-pregnancy physical examination from 11 districts in Shanghai, OR pregnant women present at first antenatal care \< 14 week of gestation
* plan to deliver in Shanghai

Exclusion Criteria:

* none
Inter- and Intra-observer Variability in First-trimester Uterine Artery Doppler Measurements.

The aim of this study is to investigate the inter- and intra-observer variability of first-trimester Uterine Artery Doppler ultrasound measurements in pregnancies between 11+0 and 13+0 weeks of gestation. Participants will undergo a measurement protocol (six sets of Doppler ultrasounds measurements of right and left uterine artery) performed alternately by two observers (sonographers or physicians who perform these ultrasounds frequently in clinical practice at the outpatient clinic).

Doppler ultrasound measurements are increasingly performed in clinical practice to detect high-risk pregnancies. First-trimester uterine artery Doppler measurement might be a potential predictor for the development of maternal hypertensive disorders later on in pregnancy. However, before implementing this measurement into clinical practice and prediction models, the test characteristics of this first-trimester Doppler measurements should be adequately studied. The objective is to assess the inter- and intra-observer variability of first-trimester uterine Doppler ultrasound measurements.

Eligibility Criteria:
Inclusion Criteria:

* Singleton pregnancy
* Gestational age from 11+0 weeks to 13+6 weeks

Exclusion Criteria:

* Maternal age \<18 years

  * Inability to give informed consent
  * Multiple pregnancy
  * Abnormal fetal heart tracings
  * Non-viable pregnancy
Knowledge, Practice and Attitude of Paediatricians Regarding Early Childhood Caries

To assess the knowledge, practice and attitude of paediatricians regarding early childhood caries and infant's oral health.

According to The American Academy of Pediatric Dentistry, Early Childhood Caries ECC is defined as the presence of one or more decayed (noncavitated or cavitated lesions), missing (due to caries), or filled tooth surfaces in any primary tooth in a child under the age of six Early Childhood Caries is a serious oral health problem worldwide with a prevalence of 61.4% in preschool children in Egypt. Bottle-feeding during night-sleep, unhealthy diet with high sugar consumption, lack of parental awareness regarding their children oral health, low socioeconomic status and lack of access for dental care were all reported as risk factors for ECC .

ECC might lead to adverse effects on children's physical, psychological and social well-being, as the associated dental pain and tooth loss can negatively influence children's nutrition, phonetics, socializing and sleeping. Moreover, treating ECC represents a financial burden for both the family and health care organizations, as it usually necessitates the aid of general anaesthesia . Therefore, more attention and efforts should be made to obtain an early assessment of oral health status of infants and children and reach the high-risk groups of ECC within populations, in order to reduce the prevalence of ECC and consequently to improve the quality of life of these children .

Paediatricians are the first to contact the infants and their families and infants often have frequent and regular visits to them than to the dentists. Therefore the paediatricians have to recognize their role in the promotion of children's oral health by several means such as; assessing the child's risk of developing dental caries, providing basic screening services for early detection of dental problems, parental education, and referral of required conditions . This is in accordance to the American Academy of Paediatric Dentistry guidelines which recommends the utilization of different preventive strategies for the prevention and early detection of ECC and also emphasizes the importance of its initiation in the primary health care provider's. .

Gaining information about the knowledge, practice and attitude of paediatricians regarding early childhood caries and infant's oral health will help identifying the points of weakness and improving their knowledge which will facilitate the early assessment of the oral health status and delivery of preventive oral measures to the infants and children which in turn may reduce or even eliminate oral diseases.

Eligibility Criteria:
Inclusion Criteria:

* Paediatricians working in hospitals. Paediatricians treating infants and children less than 6 years.

Exclusion Criteria:

* Under graduate students and interns
Influence of Dogs on Learning in Children

In a randomised controlled cross-over study, the influence of interacting with a dog on children's learning performance is investigated.


Eligibility Criteria:
Inclusion Criteria:

* healthy
* 7 - 14 years old
* willingness to participate

Exclusion Criteria:

* medical or psychiatric diagnosis
* medication
* allergia (dogs)
* phobia (dogs)
Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic Cholecystectomy

This study will be carried out to compare the efficacy of dexmedetomidine, propofol or lidocaine infusions in attenuation of hemodynamic responses to pneumoperitoneum during adult laparoscopic cholecystectomy using electrical cardiometry.

Many drug infusions have been used to control hemodynamic responses to laparoscopic surgeries like propofol, fentanyl, esmolol with varying degrees of success.

Dexmedetomidine has sedative and analgesic properties seems to be appropriate enough to control the sympathetic response as well as provide a stable hemodynamics

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists I patients.
* Patients between the ages of ≥ 20 and ≤ 60 years of both sexes.

Exclusion Criteria:

* Hypersensitivity to dexmedetomidine, propofol or lidocaine.
* Diabetic patients (Hemoglobin A1C ≥ 7).
* Hypertensive patients (Blood presssure ≥ 140/90 mmHg) or patients on medications that affect hemodynamics as clonidine, methyldopa, β blockers and calcium channel blockers.
* Impaired liver function (serum albumin ≤ 3.5 g/dl, International normalized ratio≥ 1.3, total bilirubin \>1mg/dl).
* Impaired renal function (serum creatinine \>1.2 mg/dl, blood urea \>20mg/dl).
* Morbidly obese patients with body mass index ≥ 40.
* Patients with acute cholecystitis or active infection.
* Patients taking medications that may impair cognition.
* History of seizures.
The Efficacy of Pain Management With Self-reporting Pain Monitoring System in Cancer Patient

To compare the pain scales between clinician evaluated and reported with wearable device by patients.

To compare the pain scales between clinician evaluated and reported with wearable device by patients with cancer of advanced stage.

Eligibility Criteria:
Inclusion Criteria:

* over 20 year old
* cancer pain with visual analog scale or numeric rating scale score \>/- 4
* opioids candidates
* with informed consent form

Exclusion Criteria:

* life expectancy within 3 months
Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results

Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to restore the complacency of the suture and correct the stenotic compensatory cranial deformity.

This paper proposes the combination of a helicoid osteotomy distraction osteogenesis provided by the use of springs distracting.

As demonstrated by some authors, the curved shape of the helix fits perfectly the remodeling of a curved surface as well as the skullcap. If you do not receive fixation, however, trace the helicoid of the bone osteotomy can turn on a spring that can expand or contract depending on the direction of the force that is received. This form of osteotomy was therefore chosen by the authors to induce bone compliance areas of secondary defect that should expand or compress indirectly during the process of dynamic remodeling of primary defect with springs.

Eligibility Criteria:
Inclusion Criteria:

* age between 6 months to 13 years

Exclusion Criteria:

* absence of clinical conditions for the surgical treatment
Clinical Efficacy of Cryolipolysis on the Fat of Thigh in Korean Women

The aim of this study is to evaluate the clinical efficacy of reduction of local fat on ipsilateral thigh through cryolipolysis (zeltiq) and controlateral thigh using by amplitude modulated frequency (conventional) method.

Cryolipolysis is a new concept to reduce fat since Zeltiq machine had been introduced several years ago. Several different trials such as high frequency, liposuction and chemical lipolysis to remove fat had been emerged and tried. Therefore, we would like to know the clinical efficacy of cryolipolysis through comparative experiment with former frequency method on each thigh on healthy Korean women.

Healthy premenopausal women who want to reduce the fat on thigh were included. 28 healthy volunteered women recruited for this study, 15 subjects among participated after interviewing, sampling their metabolic variables at initial visit. A total of 15 subjects would be investigated through food diary(24hour), femoral CT, anthropometric, metabolic variables at initial, 4th, 12th week. Histological examination under skin(initial and 12th week), questionnaire(4th, 12th week) for satisfaction, adverse events would be monitored during 3 month.

Eligibility Criteria:
Inclusion Criteria:

* premenopausal healthy women
* subjects with body mass index \>= 18.
* subjects with visible fat on both thigh
* subjects to understand and agree to this study protocol

Exclusion Criteria:

* subjects with cryoglobulinemia, cold urticaria, or paroxysmal cold hemogobulinemia
* subjects with pregnancy or lactation within 6 months or next 3 months
* subjects with any laboratory, or metabolic abnormalities
* uncooperative subjects to comply with the study protocol
* women taking any medication over 6 months
* subjects with menstrual irregularities
* subjects to change over 10% of the former weight within the past 6 months - any procedure such as liposuction, or another surgical procedure or mesotherapy to reduce fat within 6 months
* subjects with any dermatologic abnormalities on the target area (thigh)
* subjects with any injection into the area of intended treatment (e.g. cortisone) within 6 months
Brain Mechanism and Intervention of Executive-control Dysfunction Among Gambling Disorder

The investigators assume that transcranial Alternating Current Stimulation (tACS) could improve gambling disorder patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral striatum pathway. This study intends to test the effect of tACS treatment. Three-month follow-up assessment will be conducted to test the changing of the executive-control function and its mechanism.

Gambling disorder is become a major social and public health problem in China. Executive-control dysfunction is the main symptom of behavioral addiction like gambling disorder. Previous studies have demonstrated the relationship between cognitive dysfunction and prefrontal-ventral striatum pathway. Studies have shown that abnormal phase synchronization and phase-amplitude coupling (PAC) induced the impairment of cognition, and transcranial Alternating Current Stimulation (tACS) could improve executive-control function by adjusting the abnormal synchronization. However, it has not been verified among gambling disorder patients. The investigators assume that tACS could improve gambling disorder patients' executive-control function by adjusting the synchronization patterns and enhancing the functional connectivity of the prefrontal-ventral striatum pathway. This study intends to test the effect of tACS treatment. Three-month follow-up assessment will be conducted to test the changing of the executive-control function and its mechanism. This study will provide a practical and theoretical basis for developing a novel treatment for gambling disorder.

Eligibility Criteria:
Inclusion Criteria:

* Aged 18-60, male or female, with 9 or more years of education, and able to complete questionnaire evaluation and behavioral tests
* Meet DSM-5 (Diagnostic and Statistical Manual of mental disorders，DSM) diagnostic criteria for gambling disorder
* Have gambled for at least one year (at least once a week)
* Normal vision and hearing, or within the normal range after correction
* Agree to cooperate in the follow-up evaluation
* No metal implantation in the head, no history of nerve problems or head injury, and no skin sensitivity

Exclusion Criteria:

* Have severe cognitive impairment, such as a history of head trauma, cerebrovascular disease, epilepsy, etc.
* Have used drugs promoting cognitive function in the last 6 months
* Have impaired intelligence (Intelligence Quotient\<70)
* Abuse or dependence of psychoactive substances (except nicotine) in the last 5 years
Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)

This study aims to determine the positive predictive value of incidental cardiac uptake on bone scintigraphy for diagnosing transthyretin cardiac amyloidosis, in patients who underwent scintigraphy for reasons other than suspected amyloidosis. The study is an observational, descriptive, multicenter, national study using retrospective data from routine care. Patients with incidental cardiac uptake will be recalled for further diagnostic assessment.


Eligibility Criteria:
Inclusion Criteria:

* Adults (≥ 18 years)
* Patients who underwent bone scintigraphy with 99mTc-HMDP/DPD/PYP for any indication
* Incidental cardiac uptake (Perugini grade ≥2) confirmed by a nuclear medicine specialist

Exclusion Criteria:

* Patients under legal protection
* Patients refusing the reuse of their data after individual information
Micafungin Versus Amphotercine B in Treatment of Invasive Fungal Infection

The incidence of fungal infection has increased dramatically over the past few decades.This is due to increase in survival rates of preterm neonates, advances in medical technology and drug therapy, broad spectrum antibiotics and parenteral nutrition . The resistance to antifungal agents has increased. This study will assess the efficacy of micafungin versus amphotericin B in neonates with positive fungal culture.

Neonatal candidiasis is associated with significant mortality and morbidity and high rates of neuro-developmental impairment on follow up Prevalence of invasive fungal infection (IFI) has increased in neonates during the last two decades due to increased survival rate even in the extremely premature neonates. Candida albicans and Candida parapsilosis are responsible for the majority of candidiasis in the neonatal intensive care unit (NICU) According to the European Society for Clinical Microbiology and Infectious Diseases (ESCMID)guidelines published in 2012, Micafungin, amphotericin B deoxycholate, and fluconazole are recommended as first line treatment of invasive candidiasis in neonates Currently, fluconazole and micafungin are among the most frequently used antifungal agents for the treatment of neonatal invasive candidiasis High dose of micafungin (8 to 15 mg/kg/day) can be used with neonates and infant with invasive candidiasis In this study we will explore the effectiveness and safety of micafungin for treatment of candidiasis after fluconazole for preterm neonates with invasive fungal infection and to compare it with amphotericin B.

Eligibility Criteria:
Inclusion Criteria:

* Patient less than 36 weeks gestational age
* started fluconazole either prophylactic or therapeutic dose
* and blood culture is positive for fungal infection.

Exclusion Criteria:

* Any neonate with hepatic dysfunction for any cause (hepatitis or hepatic failure), or with elevation in AST, ALT, alkhaline phosphatase
* Any neonate hypertensive, neutropenic, thrombocytopenic
* Any neonate with elevated renal function
* Any neonate with arrythmia
Effects of Repeated Attachment Security Priming on Depressed Mood: a Clinical Study

The purpose of this study is to explore whether asking participants to visualise a secure attachment figure or a neutral event leads to differences in self-reported felt security or depressed mood. Furthermore, the investigators aim to explore whether it is possible to keep a secure prime activated over 3 days via text message visualisation tasks.


Eligibility Criteria:
Inclusion Criteria:

-Anxiety and depressive symptoms

Exclusion Criteria:

-Bipolar disorder
A Study Of Treatment Patterns And Clinical Outcomes In Patients Diagnosed With Acute Myeloid Leukemia Who Received Mylotarg in the Real-World

The aim of this observational study is to describe treatment patterns and effectiveness outcomes in a sample of oncology patients treated for AML with Mylotarg through up to two additional relapsed/refractory (R/R)-based lines of therapy (through third-line therapy). The study will use United States oncology electronic medical record (EMR) data. All study data are secondary data and will have been collected retrospectively from existing clinical data originally collected as part of routine care.


Eligibility Criteria:
Inclusion Criteria:

* Confirmed diagnosis of acute myeloid leukemia (AML) on or after 01 December 2014 through Clinical Research Nurse (CRN) review of provider documentation of AML diagnosis in the medical record;
* Receipt of Mylotarg at any point during first three lines of therapy following initial AML diagnosis;
* Age greater than or equal to 18 years at initial diagnosis of AML.

Exclusion Criteria:

- Record of 1 or more of the following confounding diagnoses at any point before or after AML diagnosis: Acute lymphoblastic leukemia; acute promyelocytic leukemia, aggressive systemic mastocytosis; hypereosinophilic syndrome and/or chronic eosinophilic leukemia; dermatofibrosarcoma protuberans; gastrointestinal stromal tumors.
Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis

The clinical trial will be carried out at the Dr. Moh. Hoesin Central Hospital, Palembang and planned from October 2022 to March 2023.

This study aims to compare the efficacy of Platelet Rich Plasma, Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell (MSC) Culture Secretome and hyaluronic acid for the Treatment of Knee Osteoarthritis

In this, prospective, Open-label study, patients with mild to moderate symptomatic knee osteoarthritis will be randomized to receive either a series of platelet-rich plasma or hyaluronic acid or Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell (MSC) Culture Secretome injections under ultrasound guidance. Each of the groups were given 5 times injection 3 cc platelet-rich plasma or 2 cc hyaluronic acid or 2cc Conditioned Medium From Umbilical Cord MSC Secretome at intervals 1 weeks.

Clinical data in the form of subjective outcome measures will be collected pre-treatment and 6 months after injection.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 30-60 years
* Suffering from grade 2 and 3 osteoarthritis (OA) was identified by two observers who differed accordingly the Kellgren and Lawrence research scale
* Patient with knee pain that had been continuing for at least 12 months with no relief using anti-inﬂammatory medications and that deteriorated with weight-bearing
* Patients can understand the nature of the study and written informed consent is given to patients

Exclusion Criteria:

* Age \> 60 years
* Acute Knee Osteoarthritis Effusions
* Patients are not willing to obey the study protocol
* There are signs of infection local or general infection or positive serology for HIV, hepatitis and syphilis
* There is a congenital disease that causes significant deformity of the knee can interfere with cell applications and interpret results
* Articular injection of the knee by any drug during the previous 3 months
* Participate in any clinical trial or treatment 30 days before the study
* Other conditions may, according to medical criteria, not support participation in this research (The recent history of knee trauma, Autoimmune rheumatic diseases, Uncontrolled systemic diseases such as diabetes or hypertension, patient with Immunosuppressive or anticoagulant treatment and cancer)