cyrilzakka/clinical-trials huggingface dataset:
The Homeogenomic Trial

A randomized double-blind placebo controlled homeopathic pathogenetic trial (HPT) will be carried out on 30 healthy adult volunteers. The remedy used for the proving will be administered in a potency of 30C. The remedy being used is a common homeopathic remedy commercially available in the US, but the exact remedy is not disclosed to participants.The purpose of the proving is twofold: 1) to determine if there is a difference in symptoms between those receiving an active versus placebo medicine, and 2) to see if there is a difference in gene expression between those who receive the homeopathic remedy or placebo. It is hypothesized that participants receiving the active medication will have more symptoms characteristic of the remedy and have specific patterns of gene expression in whole blood that are different from those in placebo recipients. Participants will record symptoms in a diary for 3 days prior to administration of study medications, during 3 day of its administration and for 3 days following completion of the study medication. Blood will be drawn for gene expression studies on the day that the study medication is started and again after taking the study medication for approximately 48 hours. An additional, optional blood draw for possible future analysis of gene expression will be done at the end of the study period.


Eligibility Criteria:
Inclusion Criteria:

* Read and Speak English

Exclusion Criteria:

* Acute illness in last 7 days
* Chronic illness requiring daily medication
* Use of homeopathic remedy within 4 weeks
* Use of homeopathic remedy of 200C potency in past 2 months
* Women who are pregnant or breastfeeding an infant
Earned Income Tax Credit Access Study

The EITC Access Study an intervention study provided to families in 7 counties in Michigan.The intervention involves appending a concentrated benefits advocacy intervention onto an existing home visiting program. There are 5 treatment counties and 2 control counties that will survey families in the home visiting program to compare the relative benefits of the added benefits advocacy intervention on the outcomes of parent mental health, intimate partner violence, economic hardship, earned income tax credit take-up, and child maltreatment.


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age, has a child in their home

Exclusion Criteria:

* Does not speak or read English, Spanish, Burmese, or Arabic
Effectiveness of Metal Protheses Covered in "Diabolo" in Treatment of Necrosis of Origin Pancreatic: Trial "DIABOLOPIG"

Endoscopic treatment of pancreatic necrosis complicated by trans digestive track (duodenal or gastric) has become a standard technique validated. The rate of high technical and clinical success (76 to 91% in 3 months) and the lower morbidity in the literature explains that validation. However this treatment is done at the cost of a higher median number of treatment sessions (4-5) explaining prolonged hospitalization, delays in rehabilitation and potentially high costs. The constant improvement of therapeutic endoscopy equipment was allowed to see the advent of metal prosthesis completely covered by a membrane allowing them endoscopic extraction with ease. It has thus been recently developed short prostheses, of large diameter (up to 15/16 mm), with broad flange (or stent "diabolo") to be considered for use in the drainage of digestive peri collections. Few studies respectively determined the effectiveness of this type of prosthesis in the drainage of peri digestive collections Under echo endoscopy and treatment of necrosis of pancreatic origin. The purpose of this work is to evaluate multicenter prospective clinical and technical efficiency of laying completely covered stent "diabolo" in echo endoscopy for the treatment of necrosis of pancreatic origin.


Eligibility Criteria:
Inclusion Criteria:

Presence of peri gastric or duodenal collection type WOPN to imaging according to the Atlanta criteria (Banks Gut 2013) with predominantly solid component (\> 50%) for imaging, requiring necrosectomy for:

* Pain and / or,
* necrosis infection (positive necrosis culture, gas bubble presence in the collection on imaging, persistent sepsis or deterioration of the patient's condition despite optimal reanimation support without documented infection) and / or,
* High Occlusion (vomiting, food intolerance and gastric stasis at imaging)

Exclusion Criteria:

* Severe coagulation disorders or hemostasis
Effects of Prolonged DAPT After Lower Extremity Percutaneous Transluminal Angioplasty (PTA) in Patients With LE-PAD

The objective of the present study was to evaluate the prognostic impact of prolonged dual antiplatelet therapy (DAPT) with acetylsalicylic acid plus clopidogrel on the incidence of major adverse cardiovascular events and major adverse limb events after percutaneous lower extremity revascularization in patients with lower extremity peripheral arterial disease (LE-PAD).


Eligibility Criteria:
Inclusion Criteria:

* LE-PAD at stage 2 of Fontaine's classification (intermittent claudication)
* successful PTA of aorto-iliac, femoro-popliteal ore below-the-knee segments

Exclusion Criteria:

* critical limb ischemia
* recent acute coronary syndrome (\< 12 months)
* recent cerebrovascular event (\< 12 months)
* recent myocardial, carotid or peripheral revascularization (\< 12 months)
* recent history of bleeding (\< 12 months)
* other indication for clopidogrel therapy
* indication for anticoagulation
* de-compensated heart failure
* malignant neoplasm
Evaluation of Abdominal Wall Thickness at Possible Trocar Sites Based on Body Mass Index

The purpose of this research study is to determine which sites are best suited for laparoscopic entry of bariatric trocars in the morbidly obese population.

Patients already scheduled for laparoscopy will be approached for participation prior to surgery. During laparoscopy, the investigators routinely inject port sites with a 21-gauge needle and inject sites with local anesthetic prior to trocar placement. In the study the investigators will insert a 21-gauge 3.5inch spinal needle perpendicular to the abdominal wall at each possible trocar site. The seven insertion sites are the umbilicus; 12cm lateral to umbilicus on right; 12cm lateral to umbilicus on left; Left lower quadrant lateral to inferior epigastric; Right lower quadrant lateral to inferior epigastric, Lower midline of abdomen; Left upper quadrant at Palmer's Point. The needle will be placed after the abdomen is insufflated under direct visualization with the laparoscopic camera. The needle will be inserted to the level of the peritoneum and a hemostat will be place on the needle at the level of the epidermis. The abdominal wall thickness will be measured with a ruler and recorded to the nearest millimeter. The information will be recorded on the case report form attached. The case report form will be kept in a binder in the research coordinators office.

Eligibility Criteria:
Inclusion Criteria:

* Patients between the age of 18-64; BMI greater than 18.5

Exclusion Criteria:

* Abdominal hernias
Impact of Screen Size on Colorectal Adenoma Detection

The purpose of this study is to assess whether the use of large screen during colonoscopy will increase adenoma detection rate.

Colorectal cancer is the 3rd most common cancer in the world. Recently in Hong Kong it has surpassed lung cancer to be the most common cancer. Hence it is essential not only to have up-to-date surgical and oncological treatment but also a need an effective preventative strategy.

In the past few decades, removal of pre-malignant colonic lesions such as adenomas have been shown to prevent development of colorectal cancers. Colonoscopy is currently the only technique which can perform both detection and treatment during the same procedure. However, concerns have been raised about the effectiveness of colonoscopy in the prevention of CRC after several studies reported unexpected high incidence rates of interval carcinomas (IC), especially in the proximal colon. Most ICs are suspected to arise from missed colon lesions during colonoscopy. Factors concerning missed colonic lesions are multifactorial such as adequate bowel preparation, skill level of endoscopists, the number of endoscopy staff in the room as "eyes" to help with polyp detection and withdrawal time.

Following a pilot study in our endoscopy unit, we believe the size of the screen projecting the endoscopic image may have a positive influence on adenoma detection. Therefore, we feel that a well-designed and adequately powered randomised controlled trial may help to confirm this.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 years or above
* Referred to the endoscopy unit for diagnostic or surveillance colonoscopy

Exclusion Criteria:

* Familial history of Familial adenomatous polyposis or Hereditary non-polyposis colorectal cancer
* Known history of inflammatory bowel disease
* Emergency endoscopy of any nature (such as for gastrointestinal bleeding, assessment of large bowel investigation and colonic decompression)
* Patients with colostomy
* Previously incomplete colonoscopy (not including insufficient preparation)
* Patients with known palliative colorectal malignant disease Patients with coagulopathies Inability to give informed consent
Use of Dermal Matrix in Breast Reconstruction

We propose to evaluate the question of whether there is a significant difference between the traditional method of serratus flap tissue expander reconstruction and the acellular matrix method.

We propose a double blinded, randomized study of 60 women comparing outcomes which will include postoperative pain, complication rates and aesthetic outcome as assessed by the patient and a plastic surgeon blinded to the method of reconstruction.

Eligibility Criteria:
Inclusion Criteria:

* All women who are candidates for breast reconstruction using tissue expanders after mastectomy

Exclusion Criteria:

* Other forms of breast reconstruction after mastectomy
Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder

This study evaluates underlying psychological and biological mediators in Internet-delivered cognitive behavior therapy for adults with social anxiety disorder.

Internet-delivered cognitive behavior therapy for social anxiety disorder has previously demonstrated to target and affect the brain´s fear network, typically neural response in the amygdala ameliorate after effective psychological treatment. Commonly, neuroimaging studies have performed brain imaging at pre- and post-intervention, yet, longitudinal study designs including several repeated measures of neural response over the course of treatment are currently missing in anxiety disorder. In the current study the participants will undergo magnetic resonance imaging (MRI) at four occasion. a) Twice before treatment initiation (9 weeks apart), b) at week 4 (during treatment), c) and directly after treatment termination.

Biological aging can be quantified at the individual cell level by measuring telomere length in peripheral immune cells (leukocytes). Telomeres are located at the end of each chromosome and protect the genetic material during cell division. Telomerase is an enzyme that can lengthen telomeres, and have in this way a protective function against accelerated cellular aging. Variations in these bodily processes have been associated with psychiatric manifestations such as anxiety and depression. In the current study the participant´s telomere length and telomerase activity will be assessed at three occasion. a) Twice before treatment initiation (9 weeks apart), and b) directly after treatment termination.

Eligibility Criteria:
Inclusion Criteria:

* Social Anxiety Disorder as primary diagnosis (DSM-5)
* Otherwise somatically healthy
* Willingness to participate in a symptom provocation brain imaging trial

Exclusion Criteria:

* Concurrent psychological treatment
* Treatment of social anxiety within the three months preceding the study
* Chronic use of prescribed medication that could influence the results (anxiolytic or antidepressant drugs, certain hypnotics or herbs like St Johns Wort)
* Contraindications for MRI investigation (implants or other metal objects in the body, brain and heart operations)
* Pregnancy or planned pregnancy during the first 6 months of the study period
* Postmenopausal women
* Any neurological disorders
* Depressive symptoms, as determined by scoring more than 20 on the MADRS questionnaire (self-report version)
* Suicidal ideation (scoring more than 2) on the self-report version of MADRS, item 9
* Suicide at moderate risk (MINI v7)
* Bipolar disorder (MINI v7)
* Psychotic syndromes (MINI v7)
* Substance abuse disorders (MINI v7)
* Alcohol abuse (MINI v7)
* Any eating disorder (MINI v7)
* Antisocial personality disorder (MINI v7)
Correlation Between NOL Index After Stimulus and Post-operative Opioid, Pain, Pre-operative Phenotype

This study evaluates the correlation between NoL index response to standardized stimulus under general anesthesia and the post-operative pain, assessed by opioid consumption and numerical pain scores after video-assisted thoracoscopy (VATS).

The NoL index, a nociception monitor using a multiparametric approach, has shown an excellent sensitivity and specificity in detecting noxious stimuli under general anesthesia. This monitor is better than any other parameter in grading nociception under general anesthesia. More recently, it has recently been shown a strong correlation between NoL index response to nociceptive stimulus and the level of opioid analgesia during surgery. No study has evaluated that NoL could predict post-operative pain so far. It has not yet been proven that NoL was correlated with post-operative opioid consumption or with post-operative pain scores.

Some phenotypic factors were previously shown to correlate with post-operative pain and opioid consumption, such as psychological factors and tests, or also assessment of some pre-operative nociceptive thresholds (NT). Pain catastrophizing was proven in several studies to correlate with acute post-operative pain.

So far, no study compared each of these preoperative psychological factors or nociceptif thresholds to the NoL index response to intraoperative standardized pain stimulus in terms of correlation with post-operative opioid requirements and pain scores.

Moreover, there is no study evaluating the pro-inflammatory protein profiles that might likely be correlated to inter-individual differences in NoL response after this standardized nociceptive stimulus under general anesthesia.

This study will assess the level of correlation between NoL index response to standardized stimulus under general anesthesia and the post-operative pain, assessed by opioid consumption and numerical pain scores after video-assisted thoracoscopy (VATS). It also evaluates the correlation between NoL index response to standardized stimulus under general anesthesia and pre-operative phenotype and post-operative pain biomarkers.

Eligibility Criteria:
Inclusion Criteria:

* Adult patient (Age 18 or older)
* ASA status I, II or III
* elective video assisted thoracoscopy under general anesthesia

Exclusion Criteria:

* history of coronary artery disease
* serious cardiac arrhythmia (including atrial fibrillation),
* history of substance abuse,
* chronic use of psychotropic and/or opioid drugs,
* use of drugs that act on the autonomic nervous system (including β-blockers),
* history of psychiatric diseases,
* allergy to any drug used in the study protocol,
* refusal of the patient
* unexpected difficult airway requesting excessive, possibly painful airway manipulations
* unexpected intraoperative complications requiring strong hemodynamic support (transfusions, vasopressors, inotropes)
* conversion to thoracotomy
Determinants of the Effectiveness of Robot-assisted Hand Movement Training

The investigators would like to investigate the effectiveness of somatosensory training for robot-assisted hand motor rehabilitation after stroke.

From previous studies, the investigators learned that stroke survivors with impaired finger proprioception did not achieve as large a functional benefit from robotic finger training. For this study, the investigators would like to determine if and the extent of finger proprioception can be improved through targeted robotic proprioceptive training combined with robotic finger movement training. The investigators would also include imagining studies via Electroencephalogram (EEG) and other baseline predictors to provide insight to determine who responds best to proprioceptive training.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 to 85 years
* Suffered from a single ischemic stroke (radiologically confirmed) at least 6-months prior to enrollment
* An ability to score at least 3 blocks on the Box and Block Test

Exclusion Criteria:

* A substantial decrease in alertness, language reception or attention
* Pregnant or lactating
* Advanced liver, kidney, cardiac or pulmonary disease
* Plan to alter any current participation in other rehabilitation therapy in the time period of the study
* A terminal medical diagnosis consistent with survival \< 1 year
* Coexistent major neurological disease
* Coexistent major psychiatric disease
* A history of significant alcohol or drug abuse in the prior 3 years
* Current enrollment in another study related to stroke or stroke recovery
* Any other medical contraindication to participation in this study evaluated by our team physician.
LAGB as a Treatment for Morbid Obesity in Adolescents

Laparoscopic adjustable gastric banding (LAGB) has been used worldwide to help selected morbidly obese adults to lose weight. The FDA has approved LAGB only for patients 18 years or older. Our hypothesis that LAGB can be used to assist selected adolescents between 14 and 17 years lose weight and that the procedure can be performed safely in this age group. We are also evaluating the effects of weight loss after LAGB on known comorbid conditions such as sleep apnea syndrome and insulin resistance, and also on psychological health.

Seventy to ninety-eight percent of obese children become obese adults. Comorbidities of obesity such as type II diabetes, fatty liver disease, hyperlipidemia, hypertension, asthma, sleep apnea, and depression are becoming increasing common in adolescents as more adolescents become obese. The only consistently durable and effective weight loss programs for the morbidly obese patients are those that include bariatric surgical procedures. The investigators believe that the best initial bariatric surgical option for adolescents is LAGB because of its low complication rates, adjustability, and reversibility. Obese adolescents ages 14-17 who meet criteria for entry will be enrolled to determine the degree of success of LAGB as measured by % excess weight loss, decreased % body fat, decreased body mass index (BMI), reduction in comorbid conditions, and metabolic parameters (including serum lipids and glucose tolerance) at intervals of 3 months, 6 months, 1 year, then annually for a total of 5 years postoperatively. Eligible patients will have been followed for 6 months by physicians in the Center for Adolescent Bariatric Surgery and: 1) will attended a minimum of 75% of visits and 2) will have failed to lose at least 20% of excess weight. Following evaluation by the team (which will include evaluations by a nutritionist, an endocrinologist, a psychologist/psychiatrist, a pediatric nurse practitioner, and a surgeon) a patient may be offered LAGB.

Eligibility Criteria:
Inclusion Criteria:

* Ages 13-17 upon entry
* BMI \>40 or \>35 with associated medical comorbidities (e.g., sleep apnea, hypertension

Exclusion Criteria:

* severe psychiatric illness
* eating disorder with purging
* previous weight loss surgery
* stated inability to comply with pre-op and post-op visits
Psoas Compartment Block Versus Fascia Iliaca Block After Total Hip Arthroplasty

A psoas compartment block has been used with good results for postoperative pain relief after total hip arthroplasty (THA). However, case reports describing serious complications after the use of this block, have been reported. The fascia iliaca compartment block (FICB) has been shown to be a reliable block for postoperative pain relief for procedures and injuries involving the hip. The investigators have not found any literature that has compared these two blocks. This study will compare the two blocks when used for post-operative pain relief after THA.


Eligibility Criteria:
Inclusion Criteria:

* ASA Class I-III
* Patients undergoing THA for osteoarthritis

Exclusion Criteria:

* Skin infections adjacent to block site
* Allergy to local analgesics
* Patient unable to understand visual analogue scale (VAS)
Minimal Invasive Treatment of Achilles Tendinopathy: Focus on Percutaneous Release (Maffulli)

To evaluate the outcome of percutaneous paratenon release for chronic midportion Achilles tendinopathy.

Since 2011 the percutaneous procedure took the place of the open release of the paratenon for the surgical treatment for chronic midportion Achilles tendinopathy in the investigators' center. In this study the investigators re-evaluate the patients undergoing percutaneous surgery since then in order to compare the outcome with the excellent results cited in literature. The patients will be contacted and asked to participate completing a VAS-score, a VISA-A score and agreeing with a clinical examination.

Approving by the Ethical Committee of UZLeuven is pending.

Eligibility Criteria:
Inclusion Criteria:

* patients that underwent percutaneous paratenon release for chronic midportion Achilles tendinopathy

Exclusion Criteria:

* insertional tendinopathy
* open intervention
* (partial) Achilles tendon rupture
Comparing Suprainguinal Fascia Iliaca Block With Erector Spinae Plane Block in Hip and Proximal Femur Surgery

Most hip fractures occur in the elderly population. Opioid-related respiratory depression is more common in the elderly population but can cause severe brain damage or death. Reducing the amount of opioids administered before, during and after surgery by adding a regional block may increase the postoperative quality of recovery, reduce chronic pain syndromes, and may potentially facilitate the participation of patients in rehabilitation.

Despite their potential advantages, peripheral nerve blocks are still not widely used in people with hip fractures.

The primary objective of this study is to compare patients' postoperative pain scores and opioid consumption.


Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years old, undergoing hip fracture surgery

Exclusion Criteria:

* Patients with solid organ dysfunction, chronic opioid or corticosteroid use, bleeding diathesis, patients receiving inpatient medication, patients with psychiatric disorders and patients who cannot be contacted after surgery.