cyrilzakka/clinical-trials huggingface dataset:
Goniometry and Goniometric Measurement on Standardised Images in Dupuytren's Disease

Measuring range of motion (ROM) is essential in detecting musculoskeletal deficits, monitoring the effects of treatment and progression of the disease. In Dupuytren's disease the active and passive extension deficits (AED, PED) of digits 4 and 5 are usually clinically measured using a universal, short arm goniometer which is considered the standard of care. Using the goniometer can be time consuming. Measuring the extension deficit on a standardised picture could improve follow up, since it is a faster and easier process to take a picture and upload it to the patients files. Though this gives rise to the question whether this kind of measurement would be equally accurate and reliable in comparison to regular clinical measurement using a goniometer.

Measuring range of motion (ROM) is essential in detecting musculoskeletal deficits, monitoring the effects of treatment and progression of the disease. In Dupuytren's disease the active and passive extension deficits (AED, PED) of digits 4 and 5 are usually clinically measured using a universal, short arm goniometer which is considered the standard of care. Using the goniometer to measure the extension deficit of both fingers, for both the proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joint can be a time consuming process. A lot of clinicians have limited time per patient, which leads to partially or completely missing data due to not performing the measurements. Measuring the extension deficit on a standardised picture could improve follow up, since it is a faster and easier process to take a picture and upload it to the patients files. Though this gives rise to the question whether this kind of measurement would be equally accurate and reliable in comparison to regular clinical measurement using a goniometer. Establishing the difference between both methods is essential to monitor change, which makes a statistical comparison of accuracy of both methods very valuable for patients with Dupuytren's disease. Furthermore, a lot of clinicians have collected and stored standardised pictures of their patient's hands over the years. Therefore this study could solidify the available data through these images, which provide valuable information for future follow up. Furthermore, proper patient education could provide the clinician with standardised images taken by the patient himself, leading to improved follow up, if images and clinical measurement prove to be equally accurate.

Eligibility Criteria:
Inclusion Criteria:

* Older than 18 years of age
* Current AED in digit 4 or 5, in the MCP or PIP joint

Exclusion Criteria:

* Abnormalities to the fingers other than Dupuytren's disease which make goniometry impossible (e.g. amputation, arthrodesis of finger joints, deformations due to rheumatoid arthritis etc.)
* Patient's unable to give a written participating consent.
* Younger than 18 years of age.
Behavioral Exercise Training to Reduce Cardiovascular Disease Risk

To test the preliminary effectiveness of a home-based exercise training (ET) intervention to improve exercise capacity (VO2 peak \& 6-minute walk distance \[6MWD\]) among prostate cancer (PC) patients compared to controls receiving healthy living education (HLE) at 12 weeks.


Eligibility Criteria:
Inclusion Criteria:

* Be diagnosed with stage II/III/IV prostate cancer
* Be currently undergoing treatment with ADT (intermittent or prolonged)
* Have completed local curative-intent treatment, including prostatectomy or definitive radiation;
* Be \>40 years of age up to 85;
* Be willing to sign an informed consent with HIPAA authorization form;
* Not have any hearing or sight impairments that result in the inability to use the telephone or hear normal conversation;
* Must be able to join an intervention group by personal computer, smartphone or telephone call and should agree to recording of an interview;
* Be without any serious medical condition that precludes safe participation in an exercise program;
* Speak English

Exclusion Criteria:

* Be unable to undergo MRI (i.e., ferromagnetic materials in body, inability to lie flat, claustrophobia);
* Have contraindications to exercise testing;
* Have pre-existing overt cardiovascular disease/heart failure;
* Active illness/infection;
* Hemoglobin \< 7.0 grams/dL
* Platelet count \< 10 x 109/L
Virtual Reality and Laser Biostimulation on Pain Perception and Dental Anxiety

Dental anxiety in children can prevent planned treatment from being carried out, negatively affect the child's relationship with the dentist and make the treatment process difficult. The most common sources of directly anticipated anxiety are known to be associated with pain. Painful experiences are anxiety-provoking for people of all ages, especially children.This study aims to evaluate the effect of virtual reality glassess (VR) and low-level laser therapy (LLLT) on dental anxiety and pain perception during local anaesthesia administration in paediatric patients.

This study aims to investigate the combined effects of virtual reality glassess (VR) and low-level laser therapy (LLLT) on dental anxiety and pain perception in paediatric patients undergoing local anaesthesia for dental procedures. Dental anxiety is a common issue in children, often leading to increased pain perception and poor cooperation during treatment. Virtual reality has been proposed as a distraction technique, while LLLT is believed to reduce pain and inflammation. By exploring the effectiveness of these two interventions, the study seeks to determine whether VR and LLLT can serve as effective adjuncts to improve patient comfort, reduce anxiety, and enhance overall treatment experience during the administration of local anaesthesia

Eligibility Criteria:
Inclusion Criteria:

* No history of systemic disease or infectious disease
* Compliant with the dental treatments to be performed in the Children's Dental Hospital and able to answer the questions asked
* Exhibiting 'positive' and 'absolutely positive' behaviours during the examination, compliant according to the Frankl scale,
* Children with no previous experience of dental treatment with local anaesthesia

Exclusion Criteria:

* Children with any systemic condition
* Mentally and physically disabled, unable to co-operate,
* Children allergic to local anaesthesia,
* Previous dental treatment experience with local anaesthesia
* Exhibiting "negative" and "strongly negative" behaviour according to the Frankl scale
* Children with eye diseases such as myopia and astigmatism
Brief Intervention to Reduce Drinking and Intimate Partner Violence in Women

The purpose of this study is to examine whether adding a brief alcohol treatment to standard violence intervention programs for women will result in reduced drinking, reduced partner violence perpetration, and reduced partner violence victimization. We hypothesize that, relative to standard care, women receiving the additional brief alcohol intervention will have better alcohol use and partner violence outcomes.


Eligibility Criteria:
Inclusion Criteria:

* Hazardous drinking
* Participation in a batterer intervention program
Evaluation of Effect of Exercise on Prescription - a Psychological Perspective

The purpose of this study is to evaluate the effect of a primary healthcare intervention called 'Exercise on Prescription' aimed at increasing level of physical activity and psychological parameters in a population of sedentary patients with increased risk of developing lifestyle diseases. The effect is evaluated using patient-reported variables.

Exercise prescriptions are used for initiating a physical active lifestyle in sedentary populations.

A Danish project called 'Exercise on Prescription' (EoP) is implemented in primary healthcare. Patients eligible for EoP are non-institutionalised adults with medically controlled lifestyle diseases or risk factors of lifestyle diseases, who are motivated to change lifestyle, able to improve health status through a physical active lifestyle, and willing to pay a fee of €100 for the intervention.

The purpose of this study is to assess the effect on: 1) Self-efficacy, 2) Readiness to change, 3) Decisional balance, 4) physical activity level, and 5) health related quality of life.

The EoP-group is compared to an intervention group receiving only motivational counselling.

Eligibility Criteria:
Inclusion Criteria:

* All patients referred to the Exercise on Prescription scheme by their general practitioner
* Volunteer to participate in the trial

Exclusion Criteria:

* BMI over 35
Using The HOPES Program in Transition Care

This pilot study will collect information about the the potential to use an evidence-based skills training program designed for older people with serious mental illness (SMI), the Helping Older People Experience Success (HOPES) program, to help nursing home residents with SMI gain the skills needed to successfully live in the community.

This pilot study will collect information about the the potential to use an evidence-based skills training program designed for older people with serious mental illness (SMI), the Helping Older People Experience Success (HOPES) program, to help nursing home residents with SMI gain the skills needed to successfully live in the community. Although HOPES was originally designed to help older people with SMI maintain their residence in the community, the curriculum holds promise for helping nursing home residents with SMI to learn how to return to life in the community. Positive findings would be used to develop a grant application for a larger study of HOPES in nursing home residents with SMI. To evaluate the feasibility and acceptability of HOPES in nursing home settings, the investigators will enroll up to 12 residents of the Glencliff Home in Glencliff, New Hampshire. Participants will be individuals interested in discharge from Glencliff and are willing to attend multiple weekly skills training classes and several assessment sessions. Study participation will last until 6 months after discharge from Glencliff.

Eligibility Criteria:
Inclusion Criteria:

* Primary DSM-IV Axis I diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder as defined in participants' chart
* An expressed willingness to be discharged from Glencliff Home to the community.
* Voluntary informed consent for participation in the study by the participant or by the participant's legally designated guardian

Exclusion Criteria:

* Terminal physical illness OR significant medical instability
* Inability to speak or and understand English
* Primary or co-morbid diagnosis of dementia
Effect of Low-glycemic Index Meals Intake on DM2 Women Under Metformin Therapy

To compare the effect of low-glycemic index versus control lunches and dinners intake on indicators of satiety, metabolic parameters and liver steatosis degree on women with type 2 diabetes under metformin therapy.


Eligibility Criteria:
Inclusion Criteria:

* Subjets with type 2 diabetes mellitus diagnosis under metformin therapy.
* Female sex.
* Aged 30 to 65 years.
* Body Mass Index (BMI) 22 to 34.9 kg / m2.

Exclusion Criteria:

* Women with insulin-releasing drugs or insulin treatment.
* Patients with diabetic nephropathy, retinopathy, chronic kidney disease, stroke.
* Subjects with hypothyroidism without treatment.
* Individuals with food allergies or intolerances.
* Women who present an intake of ≥20 g of alcohol per day quantified through a closed consumption frequency survey.
* Patients with previously diagnosed hepatitis, hepatic cirrhosis or liver cancer.
The Effect of an ASC-seeded Collagen Hydrogel on Cerebrospinal Fluid Leak Rates Following Skull Base Surgery

This project seeks to test whether a cell-seeded collagen hydrogel dressing can reduce CSF leak after skull base surgery. Normally, patients at risk for CSF leak are treated with a commercial collagen matrix called Duragen. In this study, our sterile, cGMP manufactured collagen hydrogel dressing will be seeded with the stromal vascular fraction (SVF) mechanically isolated from lipoaspirate taken intra-operatively. This SVF contains pro-regenerative adipose stem cells (ASCs). The ASC-seeded hydrogel will be used as a supplement to Duragen to reinforce the skull base closure. The goal is to establish safety as well as to secondarily evaluate for effectiveness in reducing CSF leak postoperatively.


Eligibility Criteria:
Inclusion Criteria:

* Age \>/= 18
* Planned for skull base surgery
* Able to understand and willing to sign a written informed consent form

Exclusion Criteria:

* active skull base infection
* no plan for DuraGen repair by operating surgeon
Cognitive Behavioral Smoking Cessation Intervention for Adults With Chronic Pain

Millions of individuals with chronic pain smoke and our preliminary research suggests that currently available strategies to help people quit smoking may not be effective for individuals with chronic pain. This is important in that smokers with chronic pain have worse pain-related health outcomes compared to nonsmokers with chronic pain. The primary aim of this research project is to develop a smoking cessation intervention for specific use in an outpatient clinical setting for smokers with chronic pain.


Eligibility Criteria:
Inclusion Criteria:

* Chronic pain
* Age \> 18 years
* Cigarette smoker \> 10 per day

Exclusion Criteria:

* Concurrent substance use disorder other than nicotine dependence
* Concurrent major psychiatric disorder
Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol Dependence

Purpose: Phase I focus groups with clinicians and patients will gather qualitative data to focus and inform the content of Phase II. In Phase II, 12 weeks of psychotherapy will be offered to evaluate feasibility and potential efficacy of a couples-based, integrated treatment for men with PTSD and alcohol dependence.

Hypotheses: We predict that this experimental psychotherapy, Partners Encouraging Abstinence and Coping with Emotions (PEACE), will reduce patient drinking, reduce PTSD symptoms, and improve relationship functioning.


Eligibility Criteria:
Inclusion Criteria:

* Male patients
* One to six weeks of abstinence from alcohol and other drugs
* Both partners agree to stated goals of abstinence from alcohol and drugs, reduction of PTSD symptoms, and relationship improvement
* Current diagnoses of both alcohol dependence and PTSD
* Receiving treatment for one or both disorders
* Functionally able to participate in outpatient treatment as determined by P.I. "Functionally able" includes access to transportation.
* Alcohol is "drug of choice" (History of other drugs acceptable)
* Married or cohabiting in stable relationship for at least 6 months. Separated couples may participate if attempting to reconcile
* Patient willing to sign release of information allowing researchers to communicate with patient's clinician regarding treatment goals

Exclusion Criteria:

* Spouse or partner also has an alcohol or drug problem as determined by P.I. based on report by patient or partner or as revealed on Alcohol Use Disorders Identification Test (AUDIT) or the Drug Abuse Screening Test (DAST) given to partner at intake assessment
* Mental retardation or learning disorder by clinician report or patient chart
* Psychotic disorder as determined by patient's chart or SCID
* Patient currently receiving methadone or another opiate agonist by patient report or chart
* Current fear of partner or history of severe domestic violence in the past year. An example of severe violence would be a couple reporting an episode of violence that required medical attention. Such couples will be excluded from the study and referred to domestic violence treatment. Couples who have experienced mild to moderate domestic violence may participate in Phase II of the study.
Evaluation of the Effects of Oral QLT091001 in Adults With Impaired Dark Adaptation

This is a Phase IIa proof-of-concept study to evaluate the effects of oral QLT091001 on adults with impaired dark adaptation.

This proof-of-concept study is a randomized, parallel design of two different oral doses of QLT091001 compared to placebo to evaluate treatment effects in patients with impaired dark adaptation.

Approximately 40 subjects will be enrolled in this study at approximately 7 centers in the US.

Eligibility Criteria:
Inclusion Criteria:

* Male or female subjects ≥60 yrs with early age-related macular degeneration (AMD) based on LLLC BCVA criterion or evidence of impaired dark adaptation
* Subjects with high luminance high contrast best-corrected visual acuity (HLHC BCVA) of 40 letters (20/40 Snellen) or better in the study eye
* Capable and willing to provide consent

Exclusion Criteria:

* Women of child bearing potential
* Subjects with late AMD or any other optic neuropathy in the study eye
* Subjects with posterior subcapsular cataract or multifocal intra-ocular lens (IOL) in the study eye
* Subjects who are actively participating in an experimental therapy study or who have received experimental therapy within 60 days of Day 0 or who have taken any prescription/investigational oral retinoid medication within 6 months of Day 0
* Subjects taking age-related eye disease study (AREDS) supplements containing beta-carotene
Feasibility of Treatment for Vaping Cessation

Researchers are gathering information on the feasibility of treating e-cigarette users with 12-weeks of varenicline (Chantix®) in assisting with stopping the use of e-cigarettes.

Because the process of developing nicotine dependence and the reinforcing mechanisms of nicotine delivered in high concentrations are similar between tobacco cigarettes and newer generation electronic cigarettes, the investigators hypothesize that evidence based treatment approaches used in treating tobacco dependence should be effective in treating dependence on electronic cigarettes. Since there is no existing evidence base for treatment of electronic cigarette dependence, preliminary evidence is needed from feasibility and open label studies to guide in the development of future randomized clinical trials. In this study, vaping participants will be treated with a 12 week course of varenicline as well as have nicotine dependence counseling through a certified tobacco treatment specialist followed up 12 weeks post end of medication.

Eligibility Criteria:
Inclusion Criteria:

* ≥18 years and ≤65 years of age;
* No use of tobacco in any form (except E-cigarettes) in the past 3 months;
* currently using e-cigarettes

Exclusion Criteria:

* Current moderate or severe depression
* Use of any treatments for tobacco dependence within the past 30 days;
* Recent history (past 3 months) of abuse of, or dependence on, a substance other than nicotine;
* Women who are pregnant or lactating, or who are of childbearing potential and are likely to become pregnant during the medication phase, or a male who is able to father a child, and are not willing to use a reliable form of contraception,
* Subject describes having a medical history of: a) unstable angina; b) myocardial infarction within the past 3 months; c) coronary angioplasty; or d) an untreated cardiac dysrhythmia;
* Subject currently has cancer \[excluding non-melanoma skin cancer\] not in remission;
* Known allergy to varenicline;
* Subject has a medical condition deemed by the investigators to be exclusionary to the study.
The Israeli Study for Islet Autoantibodies Screening in Families of Type-1 Diabetes Patients

We aim at establishing a research program that will offer screening for the presence of Islet Autoantibodies (IA) in relatives of people with Type 1 Diabetes (T1D).

Relatives of people with diabetes, children, and adults from our clinic and all over Israel will be offered to participate in the study. The presence of IA will be evaluated using the Detection by Agglutination-PCR (ADAP) technology developed by Enable Biosciences, which is 1,000-10,000 times more analytically sensitive than currently used methods.. When positive in the screening, multiple antibodies will be confirmed by a second sample analyzed by the ADAP technology and by a radio binding assay (RBA). People positive for one or more antibodies (stage 1 or 2 T1D) will be referred to attend an educational program at our center. This program will include diabetes education emphasizing DKA prevention as well as stress assessment for the families involved and stress alleviating interventions. After the educational visit, people at risk of developing diabetes will be referred to further follow-up and evaluation under routine medical care at our center.


Eligibility Criteria:
Inclusion Criteria:

* First degree family member (sibling or parent) of a known T1D patient
* Age 2-45 years
* Signing an informed consent

Exclusion Criteria:

* Known diabetes of any kind (type 2, MODY)
* Have a previous history of being treated with insulin or oral diabetes medications.
* Currently be using systemic immunosuppressive agents (topical and inhaled agents are acceptable)
A Study to Evaluate Response of Overactive Bladder Symptom Score (OABSS) to Treatment

This study is to evaluate change of overactive bladder symptom scores (OABSS) between, before and after solifenacin treatment to OAB subjects.


Eligibility Criteria:
Inclusion Criteria:

* Symptoms OAB for 3 months or longer
* At least 3 urgency episode in last 3 days
* Symptoms of OAB as verified by the screening 3-day bladder diary, defined by:

  * Number of micturition ≥8 times/day
  * Number of urgency episodes in 3 days ≥3

Exclusion Criteria:

* Significant stress incontinence or mixed stress/urge incontinence
* Subject with indwelling catheters or practicing intermittent self-catheterization
* Symptomatic urinary tract infection, chronic inflammation
* Diabetic neuropathy
* Subjects who are prohibited from taking solifenacin as contraindications
* Drug or non-drug treatment for OAB was started, quitted or changed in 4 weeks
* Participation in any clinical trial in 30 days except for Part-1 of RESORT
Effects of an ACT-based Psychological Treatment in Patients With Hypersexuality

Investigation of the efficacy of Acceptance and Commitment Therapy (ACT) for the psychological treatment of hypersexuality.

After being informed about the study, all patients giving written informed consent will be assessed to determine eligibility for study entry.

Patients who meet eligibility requirements will receive psychological intervention consisting in an 8-session individual on line-delivered ACT-based treatment.

The participants will be assessed through self-report instruments before and after treatment and at 3 months follow-up.

The clinical trial will not include a control group.

Eligibility Criteria:
Inclusion Criteria:

* older than 18 years-old
* Spanish speaking
* having had a sexual relationship in the last year
* significant score on the HBI Inventory (of 53 or more)
* at least 6 months of problematic pornography use or sexual practices
* clinically significant discomfort related to sexual practices
* degree of interference in his/her life of sexual practices greater than or equal to 5 out of 10
* at least one failure in his attempts to change his sexual life
* desire to improve/reduce excessive sexual behaviour

Exclusion Criteria:

* practicing meditation at least once a week in the last three months
* receiving psychological or psychopharmacological treatment
* intellectual disability
* substance dependence (use not associated with sex)
* personality disorder or other serious or chronic mental disorder diagnosed