cyrilzakka/clinical-trials huggingface dataset:
Effect of Phototherapy in Individuals With Temporomandibular Disorder.

The present study aims to evaluate the effect of phototherapy with the combination of different sources of light on pain, activity of temporal and masseter muscles, bilateral and joint mobility in subjects with TMD. It will be made a randomized, placebo-controlled and double-blind clinical trial. Individuals participate with myogenic temporomandibular disorder, being allocated into 4 groups randomly and stratified by the method of sealed envelopes. The results will be evaluated using: RDC/TMD, digital caliper, electromyography, and visual analog scale and algometry. The protocols will be used in a single session and will be evaluated in four different moments. The variables that will be investigated are pain, muscle activity and joint mobility. The analyses of the data will be performed by adopting a significance level of 5%.


Eligibility Criteria:
Inclusion Criteria:

* 18 to 40 years.
* Female volunteers.
* Diagnosis of myogenic TMD pain must masseter presenting moderate to severe according to the RDC / TMD.
* Display body mass index (BMI) less than 25 kg/m2 to standardize the sample.
* In addition, volunteers must submit scores of pain greater than 3 cm according to the Visual Analog Scale masticatory muscles.

Exclusion Criteria:

* history of neurological disorders.
* chronic neck pain resulting from a traumatic incident.
* chronic musculoskeletal condition.
* medical diagnosis of fibromyalgia; systemic disease.
* connective tissue disorder.
* having undergone physical therapy use of analgesic, muscle relaxant.
Nephropathy in Patients With Sickle Cell Disease

There are some diseases that give rise to diverse renal manifestations as does sickle cell disease

Such involvement adversely affects virtually all major physiological processes in the kidney, and leads to complications that are common and chronic on the one hand (such as impaired urinary concentrating ability), and those that are rare and uniformly fatal on the other (such as renal medullary carcinoma) This steady adverse renal sequelae shortens the average lifespan of patients with SCD.

Proteinuria and a reduced glomerular filtration rate are risk factors associated with increased mortality among those patients with approximately 16-18% of overall mortality in this patient group is due to kidney disease.

Once end stage renal disease is reached, the mortality of patients who are on haemodialysis and have SCD is increased severalfold relative to the mortality of patients who are on haemodialysis but do not have SCD.

Thus,although the average lifespan of patients with SCD has increased during recent decades owing to improved management of complications outside the kidney,kidney disease contributes substantially to the still increased mortality in SCD.

Eligibility Criteria:
Inclusion Criteria:

* All patients with sickle cell anemia attending the unit will be included in the study.

Exclusion Criteria:

* patient with any underlaying systemic diseases other than sickle cell anaemia
Pilot Test of a Community-based Buprenorphine Treatment Intervention

The main goal of this study is to pilot test the community-based buprenorphine treatment (CBBT) intervention, examining buprenorphine treatment initiation, opioid use, and HIV risk behaviors. Two groups of participants will be followed for 60 days, with 3 research visits. One group will be enrolled prior to the CBBT intervention (pre-intervention), and one group after the CBBT intervention (post-intervention). Data sources will include questionnaires, urine toxicology tests, and medical record data. Investigators hypothesize that compared to the participants in the pre-intervention group, participants in the post-intervention group will be more likely to initiate buprenorphine treatment, reduce opioid use, and reduce high-risk HIV risk behaviors.


Eligibility Criteria:
Inclusion Criteria:

* at least 18 years old
* English or Spanish fluency
* ever injected drugs
* not receiving buprenorphine treatment (no prescribed buprenorphine in the previous 6 months)
* clients of our collaborating community-based organization
* interested in buprenorphine treatment

Exclusion Criteria:

* pregnant
* taking more than 60mg of methadone daily in the previous 30 days
Caregiver Experiences With Tracheostomy

This study aimed to determine the experiences of primary caregivers of patients with tracheostomies on tracheostomy suctioning procedure. This is a semi-structured qualitative study.

The study sample consisted of eleven (11) primary caregivers of patients with tracheostomies who were hospitalized in the otolaryngology clinic of a university hospital in a province located in the northwest of Turkey. This study was conducted using a semi-structured interview technique with the primary caregivers of the patients. Interviews were audio-recorded during the data collection procedure. The content of the audio recordings obtained during each interview was evaluated by the researchers using the content analysis method. The data were categorized, coded, and analyzed by creating themes and sub-themes. It was observed that the primary caregivers of the patients expressed fear, sadness, and anxiety during the suctioning procedure performed by healthcare professionals or themselves during their hospitalization. It was determined that caregivers need information on suctioning practice and insufficient knowledge on emergencies worries them as well.

Eligibility Criteria:
Inclusion Criteria:

* Being a caregiver of patients with tracheostomy over the age of 18
* Volunteer.
* Being the primary caregiver of the patient,
* Ability to communicate verbally
* Normal psychological state.

Exclusion Criteria:

* Being a caregiver of tracheostomy patients younger than 18 years of age
* Rejecting the voluntary event,
* Not being the primary caregiver of the patient,
* Inability to communicate verbally
* Having a psychological disorder
Impact of Time on Sexual Function (FSFI® Score) After Hysterectomy

In France, more than 62 000 hysterectomies are performed each year. Female sexual function is the result of multiple psychological, social and physiological factors. There is no information in the current literature about the optimum time between the surgery and the sexual relation resumption. The primary outcome is to assess the impact of advising time between hysterectomy and sexual relation resumption by using FSFI® score. Secondaries outcomes are: to describe and compare post-operative complications in the two groups of the study, to describe the follow-up of the recommendation concerning time between surgery and sexual relation resumption and to describe why this recommendation was not followed. This study is based on 4 questionnaires: FSFI® pre-operative and post-operative, pre-operative questionnaire and post-operative questionnaire. This is a monocentric, comparative, of superiority, randomised and prospective study. Patients are randomised into two groups: sexual relation resumption advised 4 weeks after surgery, or 8 weeks. The inclusion criteria are more than 18 years, francophone, in sexual activity, scheduled for a total hysterectomy for benign indication (menometrorrhagia, fibroma, adenomyosis, endometriosis, pelvic floor disorders, low-grade endometrial cancer), considering vaginal, laparoscopic and abdominal approach, and a written consent. Non-inclusion criteria are illiteracy, cognitive disorders, without social security, deprived liberty by judicial or administrative decision, psychiatric care, patient with legal protection, patient incapable of giving consent. If our conclusions confirmed our hypothesis, it can improve clinical practices by providing additional informations for surgeon and patient, to undergo this surgery as serenely as possible.


Eligibility Criteria:
Inclusion Criteria:

* Patient ≥ 18 years old,
* Francophone,
* Sexually active,
* Receiving a conservative or non-conservative total hysterectomy for benign pathology\*,
* Having signed a consent form. All surgical approaches are considered, laparoscopic approach with laparoscopic or vaginal closure, vaginal approach and laparotomy.

  \*The indications for the procedure selected for this study include:
* Menometrorrhagia,
* Fibroids,
* Adenomyosis,
* Endometriosis,
* Pelvic statics disorder,
* Cervical dysplasia,
* Endometrial cancer not requiring lymph node dissection or additional treatment.
Green Hospital Awareness

Environmentally conscious hospitals plan their designs as green hospitals and aim to use resources efficiently. Green buildings are defined as buildings that respect nature, are ecological, comfortable and reduce energy consumption. The aim of our study is to investigate the awareness level and satisfaction of the employees of a small private hospital in the city center without a "green hospital" certificate regarding the "green hospital" elements.


Eligibility Criteria:
Inclusion Criteria:

* consisting of health professionals and employees
* working in a small private hospital that does not have a "green hospital" certificate

Exclusion Criteria:

* who refused to participate in the survey
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-3 - 6

The purpose of this study is to assess the abuse liability and examine the reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in healthy, non-drug dependent volunteers.

not available at this time

Eligibility Criteria:
Inclusion Criteria:

Individuals must be healthy, non-drug dependent volunteers, be at least 18 years of age, and have no prior history of drug or alcohol abuse or dependence. Subjects must have had some minimal experience with opioids (e.g. at least two prior exposures)

Exclusion Criteria:

Individuals with evidence of an active Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Axis I psychiatric disorder (e.g. psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g., liver or cardiovascular disease) or pregnant female subjects are excluded from study participation.
Sero-epidemiology of Priority Arboviruses in French Guiana

Dengue is an important public health problem despite the efforts of local health authorities to mitigate the impact of epidemics and the epidemiology of dengue evolved from an endemo-epidemic to a hyper-endemic state. In late 2013, the first local transmission of chikungunya virus in the Americas was identified in Caribbean countries and territories including French Guiana. Rapidly, more than 16,000 suspected local Health authorities had reported cases. In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil. The emergence of Zika virus in South America led to a rapid spread throughout South and Central America, reaching French Guiana in December 2015. With the increasing frequency of epidemics related to arbovirus and the resulting health, social, and economic impacts of dengue, the surveillance of arbovirus have become social, political, and public health challenges that require specific and non-available immune status information.

French Guiana is a 250,000 inhabitant's French overseas department located in South America, the epidemiology of arboviruses has recently evolved and marked by important outbreaks.

Dengue remains an important public health problem despite the efforts of local health authorities to mitigate the impact of epidemics and the epidemiology of dengue evolved from an endemo-epidemic to a hyper-endemic state. In late 2013, the first local transmission of chikungunya virus in the Americas was identified in Caribbean countries and territories including French Guiana. Rapidly, more than 16,000 suspected local Health authorities had reported cases. In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil. The emergence of Zika virus in South America led to a rapid spread throughout South and Central America, reaching French Guiana in December 2015. With the increasing frequency of epidemics related to arbovirus and the resulting health, social, and economic impacts of dengue, the surveillance of arbovirus have become social, political, and public health challenges that require specific and non-available immune status information.

Eligibility Criteria:
Inclusion Criteria:

* Guiana resident for at least 6 months and present during the entire study period
* Age between 2 and 75 years old

Exclusion Criteria:

* Subject under guardianship or deprived of liberty by judicial decision
* Subject with any pathology or health problem not compatible with blood sampling
Study of Preoperative Docetaxel or Cisplatin (CDDP) + Docetaxel for C-stage IB-II Non-Small Cell Lung Cancer (NSCLC)

The purpose of this study is to evaluate the safety and efficacy of the preoperative docetaxel and docetaxel-cisplatin combination in c-stage IB/II NSCLC, and select the optimal preoperative therapy for phase III trials.

Preoperative chemotherapy has substantial theoretical advantage. Several controlled trials are under way in early stage (clinical stage IB-II) nonsmall cell lung cancer (NSCLC). In each trial, platinum-based doublet chemotherapy is employed. Although platinum-based doublet is the treatment of choice for advanced NSCLC, risk/benefit balance might well be different in earlier stages. There have been no prospective randomized trials to choose an optimal preoperative chemotherapy in early stage NSCLC.

Comparison: Preoperative cisplatin-docetaxel combination versus docetaxel monotherapy in clinical stage IB/II NSCLC.

Eligibility Criteria:
Inclusion Criteria:

* Newly diagnosed, pathologically documented NSCLC
* Clinical stages IB (T2N0M0), IIA (T1N1M0) or IIB (T2N1M0 or T3N0M0)
* Ages: 15-74 years old
* ECOG performance status 0 or 1
* Measurable disease
* Ample organ function
* Signed informed consent

Exclusion Criteria:

* Invasion to the first rib or more superior chest wall
* Metastasis to, or involvement of, mediastinal node
* Active concomitant malignancy
* Unstable angina, recent myocardial infarction, or heart failure
* Uncontrolled diabetes or hypertension
* Pregnant or lactating women
* Other severe complications
* Systemic use of corticosteroids
Stress, EEG, ECG, and Chiropractic

The Life University Center for Chiropractic Research is conducting a study to better understand the relationship between subjective stress measures and brain patterns during resting state and an auditory oddball task. A secondary aim is to evaluate the impact of a single session of chiropractic care on the resting state and P300 time locked response after a one-week wait period. An additional outcome assessment for this study will be the recording of an electrocardiogram (ECG) of each participant that will be used to analyze their heart rate variability (HRV). Eligible individuals will receive a physical exam to ensure safety during all procedures. They will then sit for a 6-minute resting state EEG and an auditory oddball task. They will complete a series of questionnaires assessing stress. They will receive a chiropractic adjustment using a handheld instrument called an Activator. They will return one week later for a follow-up assessment consisting of the 6-minute resting state EEG, auditory oddball task, and the questionnaires assessing stress.


Eligibility Criteria:
Inclusion Criteria:

* Individuals between the ages of 18 and 40
* Individuals who can wear an EEG cap for 40 minutes
* Individuals who can sit quietly for at least 15 minutes
* Individuals who have not had a chiropractic adjustment within the last two weeks
* Individuals who have not received any other interventions, such as osteopathic spinal manipulation, physical therapy rehabilitation or manipulation, massage, body movement therapies or acupuncture within the last 2 weeks.

Exclusion Criteria:

* Individuals who have been diagnosed with a serious mental disorder such as schizophrenia or major depressive disorder that could influence EEG results
* Individuals who do not feel they can sit quietly with limited movement for roughly 15 minutes
* Individuals who are on psychotropic medications (e.g. Benzodiazepine medications) that influence EEG readings (Benzodiazepine medications include but are not limited to: alprazolam, chlordiazepoxide, clobazam, clonazepam, clorazepate, diazepam, estazolam, flurazepam, lorazepam, midazolam, oxazepam, temazepam, triazolam, etc.)
* Individuals with any injury or surgery to the skull in the last 6 months, or a history of trauma to the head such as a concussion or stroke
* Individuals with a hearing impairment (due to the auditory stimulus recording being performed)
* Individuals who are currently pregnant
* Individuals with a current litigation related to a physical, health-related injury
* Individuals with untreated diagnosed osteoporosis or articular instability, such as atlanto-axial instability
* Individuals with a known heart condition that results in an aberrant ECG recording
Antibiotic Elution in Total Knee Arthroplasty

The purpose of the study is to characterize and quantify the level of antibiotics eluted from antibiotic laden cement after primary cemented total knee arthroplasty.

Patients will be identified by medical record review to make sure they meet inclusion and exclusion criteria.

Patients that qualify and sign consent will be randomized to 1 of 4 antibiotic cement groups which are pre-mixed tobramycin, hand-mixed tobramycin, hand mixed vancomycin, and hand-mixed tobramycin and hand mixed vancomycin. Study patients will be blinded to their study group. Intraoperative fluid from the knee prior to surgery and postoperative drain fluid from the knee postoperatively will be collected as well.

Patients will be identified by medical record review to make sure they meet inclusion and exclusion criteria.

Patients that qualify and sign consent will be randomized to 1 of 4 antibiotic cement groups which are pre-mixed tobramycin, hand-mixed tobramycin, hand mixed vancomycin, and hand-mixed tobramycin and hand mixed vancomycin. Study patients will be blinded to their study group. Intraoperative fluid from the knee prior to surgery and postoperative drain fluid from the knee postoperatively will be collected as well.

Eligibility Criteria:
Inclusion Criteria:

* Age over 18
* Total knee arthroplasty for primary osteoarthritis performed by Dr. Rick Wright.
* Primary diagnosis of knee osteoarthritis

  * Exclusion Criteria:
* Diminished mental capacity
* Vancomycin allergy
* Tobramycin allergy
* Patient history requiring IV administration of vancomycin or tobramycin perioperatively
* Chronic kidney disease stage III and stage IV
Resistive Expiratory Muscle Training in COPD Patients

* To determine effects of resistive expiratory muscle training on pulmonary functions in Chronic obstructive pulmonary disease (COPD) patients
* To determine effects of resistive expiratory muscle training on maximum expiratory pressure in COPD patients
* To determine effects of resistive expiratory muscle training on quality of life in COPD patients


Eligibility Criteria:
Inclusion Criteria:

* COPD patients (GOLD criteria - moderate, moderately severe)
* Borg scale \< 4

Exclusion Criteria:

* Patients with Orthopedic disease
* Neurological disease,
* Cognitive impairment (Mini-Mental State Examination \< 22) ,
* Heart diseases,
* Pulmonary fibrosis
* Obstructive sleep apnea syndrome.
* Acute and chronic infections
Epidemiology of Psychiatric Disorders in Children and Adolescent at Egypt

Pediatric, developmental and mental health problems are more common than renal, cardiac and renal problems.

Compartmental problems were often conceptualised across two broad spectrums: internalising intrapersonal problems like anxiety, depression and withdrawal and externalising problems such as Interpersonal problems such as hyperactivity and aggression.

Mental disorders with long-term consequences can result in children and adolescents, undermining health compliance and reducing societies' ability to be safe and productive. As, children and adolescent have long-term deteriorating effects of mental health problems are often serious.

Early detection and identification of problems are in the best interest of children, adolescents, their families, and the community as a whole. All three are important.

how epidemiology can help our understanding of children and adolescent mental health: the burden of the community, measurement and tracking highly significant.

This study will display the first large-scale study of psychiatric disorders in children and adolescents in the Egypt . to provide services, including prevention and intervention based on evidence of mental health, a population-representative child survey and adolescent mental estimates disorders were needed urgently


Eligibility Criteria:
Inclusion Criteria:

1. age of children (2-18 years)
2. both males and females.
3. living in Egypt.

Exclusion Criteria:

* unwilling parent to recruited in the study.
Cologne Esophageal Response Prediction Study (CERP-Study)

RATIONALE: The prognosis of patients with advanced esophageal cancer may be improved by preoperative chemoradiation. But only those patients have a benefit from this additional therapy, whose tumor shows a response after chemoradiation. Molecular markers may help to identify before starting the therapy those patients who response.

PURPOSE: This is the first prospective, clinical trial to study the impact of ERCC1 to predict histopathological response to neoadjuvant radiochemotherapy (RTx/CTx) in patients with cancer of the esophagus.


Eligibility Criteria:
Inclusion Criteria:

* informed consent
* newly diagnosed adenocarcinoma or squamous cell carcinoma of the esophagus or cardia

Exclusion Criteria:

* missing informed consent
* prior radiation or chemotherapy
* second malignancy
The Effects of Intubation Via McGrath Videolaryngoscope on Intraocular Pressure

In this study, the investigators aimed to compare the effects of endotracheal intubation via direct laryngoscope (DLS) and McGrath Videolaryngoscope (VL) on intraocular pressure.

Total of 50 American Society of Anesthesiologist Grade 1-2, Mallampati score 1 or 2, age between 18 to 65 patient planned to undergo nonopthalmic surgery will be included to study. Patients with glaucoma, diabetes mellitus, cardiovascular and pulmonary diseases, American Society of Anesthesiologist Grade III and IV, Body mass index more than 35, difficult intubation, undergo obstetrical surgery and propofol, fentanyl, rocuronium contraindicated will be excluded from the study. Patients will be divided randomly into 2 groups as direct laryngoscopic and videolaryngoscopic intubation group. Patients will be preoxygenated with %100 O2 for 3 minutes then anesthesia will be induced using propofol 2 mg / kg, fentanyl 1 mcg/kg, and rocuronium 0,5 mg / kg in both groups. After 3 minutes mask ventilation, patients will be intubated (women with No:7-7,5, men with No:8-8,5 intubation tube) by oral route. systolic blood pressure, diastolic blood pressure, mean arterial pressure, peripheral oxygen saturation, perfusion indexwill be recorded and intraocular pressure measured by ophthalmologist by tonopen device will be recorded pre-induction (basal), after induction, 1,2,3,5 minutes after intubation, respectively. Period between handling of laryngoscope or videolaryngoscope after termination of mask ventilation and obtain end tidal carbon dioxide will be accepted as application time and recorded. Study will be terminated after 5th minute values taken.

Eligibility Criteria:
Inclusion Criteria:

* ASA (American Society of Anesthesiologist) Grade 1-2,
* Mallampati score 1 or 2,
* Age between 18 to 65,
* Patient planned to undergo nonopthalmic surgery

Exclusion Criteria:

* Patients with glaucoma, diabetes mellitus, cardiovascular and pulmonary diseases, ASA Grade III and IV, BMI more than 35,
* Patients with difficult intubation,
* Patients undergoing obstetrical surgery and propofol, fentanyl, rocuronium contraindicated