cyrilzakka/clinical-trials huggingface dataset:
Complete Decongestive Therapy Versus Compression Bandaging in Advanced Secondary Lymphedema

The purpose of this study is to:

Find out the efficacy of using complete decongestive physiotherapy on limb volume in advanced secondary upper and lower extremity lymphedema patients.

Find out the efficacy of compression bandaging on limb volume in advanced lymphedema patients.

This study was conducted to compare between the efficacy of complete decongestive therapy (CDT) and compression bandaging in advanced secondary lower extremity lymphedema.

The study was conducted at the department of plastic surgery, Kasr Al-Ainy hospital. Sixty patients of both genders aged from 40 to 55 years old were participated in this study, and they were randomly assigned to two study groups.

Group I: Thirty patients received CDT (60 min of manual lymph drainage MLD, compression bandaging, exercises, and skin care).

Group II: Thirty patients received compression bandaging alone. The same bandaging scheme used for both groups. The therapy included 12 interventions performed 5 days a week, during the first two weeks in addition to another successive two sessions at the third week, i.e., for a total of twelve sessions.

Evaluation of limb volume using water volumetry and 4-cm truncated cone circumferential measurements were done before treatment application, after 6 sessions (post 1) and after 12 sessions (post 2).

Eligibility Criteria:
Inclusion Criteria:

Patients with lower limb lymphedema (stage II and III) secondary lymphedema aged from 40 to 55 years old, with BMI less than 35 and duration of illness ranged from 3-9 years were included in the study

Exclusion Criteria:

the patients were excluded if they have acute erysipelas, acute thrombophlebitis phlebothrombosis and decompensated heart failure.
Evaluation of the Efficacy of Permanent Course Combined Therapy With CYTOFLAVIN® Intravenous Solution and CYTOFLAVIN Tablets, at 2-3 Stages of Rehabilitation of Patients With Post Intensive Care Syndrome

Post intensive care syndrome (PIC syndrome) is an important problem in modern intensive care strategy. Understanding the mechanisms of PIC syndrome helps prevent it in patients with respiratory, neuromuscular transmission, and cognitive impairments that require prolonged support of vital functions. Significant role in the formation and severity of PIC syndrome is played by the severity of the systemic inflammatory response, which is an individual reaction of the body, and this determines the degree of neurological and psychological deficits. Chronic diseases such as diabetes mellitus, especially in the context of metabolic syndrome, worsen the course of PIC syndrome and delays recovery. Early initiation of rehabilitation measures in the intensive care unit and subsequent expansion of the individual rehabilitation program contributes to the rapid and successful recovery of not only vital functions, but also cognitive, motor and emotional disorders. This shortens the hospital stay of patient and improves their quality of life after discharge.


Eligibility Criteria:
Inclusion Criteria:

* Men and women over 18 years of age and older;
* Stay in the ITU and (or) intensive care unit for at least 3 days;
* Diagnosed "post intensive care" syndrome (PIC syndrome) with moderate-to-severe severity \>3\<6 points
* Diagnosed modalities "critical illness polyneuropathy, respiratory neuropathy, dysphagia" of the domain "Neuromuscular complications" of PIC syndrome at 2-3 stages of the rehabilitation route at any value of PICS severity index
* Diagnosed modalities "decreased gravitational gradient, decreased exercise tolerance" in the domain "Vegetative-metabolic complications" at 2-3 stages of the rehabilitation route at any value of PICS severity index

Exclusion Criteria:

* Premorbid level of vital activity when assessed on the rehabilitation routing scale 4-5 points;
* Hematocrit ≤30%;
* Hemoglobin level ≤80 g/L;
* Acute cardiac failure;
* Acute respiratory failure;
* Acute renal failure;
* Acute liver cell failure;
* Use of drugs from "metabolic agents" pharmacotherapeutic group at the time of inclusion in the study
* Life expectancy of 6 months or less or presence of incurable diseases in decompensation stage
A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

The purpose of this study is to compare the efficacy and safety of pirtobrutinib (LOXO-305; Arm A) compared to BR (Arm B) in patients with CLL/SLL who have not been treated. Participation could last up to five years.


Eligibility Criteria:
Inclusion Criteria:

* Confirmed diagnosis of CLL/SLL requiring therapy, per iwCLL 2018 criteria
* Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
* Adequate organ function
* Platelets greater than or equal to (≥)75 x 10⁹/liter (L) (≥50 × 10⁹/L for patients with evidence of bone marrow infiltrate), hemoglobin ≥8 grams/deciliter (g/dL), and absolute neutrophil count ≥0.75 x 10⁹/L
* Kidney function: Estimated creatinine clearance ≥40 milliliters per minute (mL/min)

Exclusion Criteria:

* Known or suspected Richter's transformation at any time preceding enrollment
* Prior systemic therapy for CLL/SLL
* Presence of 17p deletion
* Central nervous system (CNS) involvement
* Active uncontrolled auto-immune cytopenia (e.g., autoimmune hemolytic anemia \[AIHA\], idiopathic thrombocytopenic purpura \[ITP\])
* Significant cardiovascular disease
* Active hepatitis B or hepatitis C
* Active cytomegalovirus (CMV) infection
* Active uncontrolled systemic bacterial, viral, fungal, or parasitic infection
* Known human immunodeficiency virus (HIV) infection, regardless of cluster of differentiation 4 (CD4) count
* Concurrent use of investigational agent or anticancer therapy except hormonal therapy
* Patients requiring therapeutic anticoagulation with warfarin or another Vitamin K antagonist
* Vaccination with a live vaccine within 28 days prior to randomization
* Patients with the following hypersensitivity:

  * Known hypersensitivity, including anaphylaxis, to any component or excipient of pirtobrutinib or bendamustine
  * Prior significant hypersensitivity to rituximab
Effectiveness of eHealth on the Self-management of Health Status and QOL Among CAD Patients

This article uses the smart medical case management tracking system, combined with various terminal devices to fully record the measured data (pulse, blood pressure) for case home care tracking to prevent the occurrence and deterioration of the disease. Therefore, with the promotion of the eHealth medical staff and members of the family can instantly grasp the health of the body and cultivate the habits of self-health management and enhance the quality of care. Therefore, we hope to use the Smart Health Cloud as an interventional measure to improve the care of patients with coronary artery disease, improve self-management ability and quality of life.

The World Health Organization points out that cardiovascular disease is the number one killer of global deaths, killing 17.1 million people worldwide each year, accounting for 31% of the world's total deaths. Heart disease is the second leading cause of death in China. Coronary artery disease (CAD) is the majority, and coronary artery disease is the most common cardiovascular disease. Good self-management can reduce disease risk factors and improve related prognosis. It is also an important issue in health promotion around the world. This article uses the smart medical case management tracking system, combined with various terminal devices to fully record the measured data (pulse, blood pressure) for case home care tracking to prevent the occurrence and deterioration of the disease. Therefore, with the promotion of the eHealth medical staff and members of the family can instantly grasp the health of the body and cultivate the habits of self-health management and enhance the quality of care. Therefore, we hope to use the Smart Health Cloud as an interventional measure to improve the care of patients with coronary artery disease, improve self-management ability and quality of life.

Eligibility Criteria:
Inclusion Criteria:

* A patient who is 20 years of age or older and has a Coronary computed tomography angiography \>50% vascular stenosis, has been PTCA、stent or CABG
* Taiwanese, understand Chinese

Exclusion Criteria:

* Those who can't express their wishes clearly (such as Azheimer's disease, mental dysfunction)
* mental disorder
* infectious diseases
* Patients who participate in other research projects
Body Awareness and Spinal Stability in Scoliosis

Thirty volunteer patients diagnosed with scoliosis by a specialist physician at Gazi University Hospital Orthopedics and Traumatology Department and subsequently referred to Gazi University Physiotherapy and Rehabilitation Department for exercise training will be included in the study. The lumbar Pressure Measurement Test with Stabilizer and Rotation Stability Tests will be utilized to evaluate the spinal stability of the patients. Body awareness will be assessed using the Body Awareness Survey, comprising 18 questions. All assessments will be conducted at the Orthopedic Rehabilitation Clinic within the relevant department.

The results obtained from this study will elucidate the relationship between body awareness and spinal stability in individuals with scoliosis.

The data obtained from the study will be analyzed using the Statistical Package for the Social Sciences (SPSS) software (IBM Corp., Armonk, NY, USA). Results will be presented as Mean ± Standard Deviation (X ± SD), percentage (%), or median with interquartile range (IQR), depending on their distribution normality. Data conforming to a normal distribution will be compared using the Independent Samples Student's t-test, while those not conforming will be analyzed using the Mann-Whitney U test. The relationship between variables will be assessed using the Spearman Correlation Test. A significance level of p \< 0.05 will be utilized to determine statistical significance.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of idiopathic scoliosis by an orthopedist
* The Cobb angle measured on the standard scoliosis radiograph should fall within the range of 10°-45°.

Exclusion Criteria:

* Presence of any orthopedic or neurological disease affecting trunk and extremity mobility, excluding scoliosis.
* History of previous spine or orthopedic surgery.
The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery

The purpose of study is to compare the incidence of acute kidney injury in patients receiving perioperative dexmedetomidine or placebo undergoing valvular heart surgery.


Eligibility Criteria:
Inclusion Criteria:

* adult patients over the age of 20 scheduled for valvular heart surgery

Exclusion Criteria:

* Left ventricular-ejection fraction \< 30%
* Preexisting congestive heart failure
* Severe coronary artery disease
* Hemodynamically unstable arrhythmia
* Cardiogenic shock during perioperative period
* Ventricular assist device
* Severe renal dysfunction (eGFR \< 15ml/min per 1.73m2)
Cognitively Enriched Walking Program

Dementia currently affects more than 47 million people worldwide, its prevalence is forecasted to triple by 2050, and it has been reported to be one of the most costly disorders in Belgium. There is good scientific evidence that the cognitive impairments associated with the development of dementia can be lessened or even reversed thanks to the plasticity of the brain (rewiring). Recent research has shown that physical activity combined with performing cognitively challenging tasks is a very potent way to induce this rewiring of the brain, which can enable people to improve their cognitive functions. Yet, so far, these studies are mainly limited to controlled laboratory conditions. The investigators developed a real-life cognitively enriched walking program, with input from experts and end-users. In this study, the investigators will examine the added value of enriching physical activity (walking) with cognitive exercises in improving cognition of older adults by conducting a six-month community-based randomized controlled trial. The investigators will also examine the longer term effectiveness in a follow-up measurement visit six months after the program. The investigators will focus on the following outcomes: cognitive functioning (i.e., objective, subjective and cognitive activity), psychosocial wellbeing (i.e., loneliness, social support, depressive symptomatology, positive wellbeing and expectations regarding aging), physical activity (i.e. both objective and subjective) and general health.


Eligibility Criteria:
Inclusion Criteria:

1. male and female volunteers
2. aged 65 years and older
3. community-dwelling

Exclusion Criteria:

1. Have a neurodegenerative disorder (i.e. Alzheimer's disease, Parkinson's disease, Multiple Sclerosis,...);
2. Are diagnosed with mild cognitive impairment (MCI);
3. Are diagnosed with a psychiatric disorder (e.g. schizophrenia, bipolar disorder, borderline personality disorder,...);
4. Are currently having a depressive episode;
5. Have had a serious brain injury in the past year, or before and still experience consequences (i.e. traumatic brain injury, stroke, brain haemorrhage);
6. Have a history of, or current, addiction to drugs or excessive alcohol abuse;
7. Are not able to walk approximately three kilometres in one hour (at an average walking pace);
8. Make use of a walking aid (i.e. a cane, a (rollator) walker, or a wheelchair);
9. One or both of their parents were diagnosed with juvenile dementia;
10. Know in advance that they will not be will not be present for one or more periods of longer than one month (e.g. because of a long holiday).
Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant Pleural Effusions.

Aim of this study is to compare two methods of pleurodesis for refractory malignant pleural effusions, in terms of safety and efficacy.

The study compares prospectively two groups of patients with refractory maignant pleural effusion. Group A consists of patients undergoing video-assisted hyperthermic pleural chemoperfusion (with a pump machine) and group B includes patients undergoing bed-side tube thoracostomy and talc slurry pleurodesis.

Eligibility Criteria:
Inclusion Criteria:

* Recurrent symptomatic malignant pleural effusion
* No prior intrapleural therapy
* Abscence of bronchial obstruction or fibrosis preventing lung reexpansion
* No systemic chemotherapy immediately prior to or during the first 30-day interval following pleurodesis

Exclusion Criteria:

* Poor Karnofsky Performance Status
Improving Aspirin Use Among Adults at Risk for Cardiovascular Disease (CVD)

The investigators' aim is to implement an intervention to increase aspirin prophylaxis use among patients that is patient initiated, optimizes use of physician and staff time, appropriately compensates staff, provides clinicians with tools necessary for managing aspiring prophylaxis, and ensures continuous management.

This intervention addresses a fundamental question of how clinicians need to be directly involved in motivating behavior change (i.e., aspirin prophylaxis). While complex behavior change likely demands high levels of involvement, a single simple action (aspirin prophylaxis) may not require such complex interactions.

We propose to compare the effectiveness of three models of care in a rigorous randomized controlled trial that will consist of a 3-arm, within-clinic design in which patients will be randomized to either the physician-initiated, the patient-initiated model, or to a control group in which usual care is delivered. In a patient-initiated model, patients are active participants in their own care and receive a pre-visit summary that contains an individualized risk assessment and patient education. In the physician-initiated model, patients receive the pre-visit summary and the physician uses a clinical decision support tool through the electronic health record that details the patient risk of CVD.

The specific aims of the proposed work are to compare the reliability and overall effectiveness of two different methods for motivating patients to take aspirin to prevent stroke and heart attacks as well as to develop a plan for translating the intervention into a process that is suitable for a paper-based clinic.

Eligibility Criteria:
Inclusion Criteria:

Patients with an appointment in the Geisinger clinic who:

* are between the ages of 45-70 (male) or 50-70 (female), and
* have one of the following risk factors:

  1. Smoke
  2. Direct LDL \> 160 mg/dl
  3. HDL \< 45 mg/dl (males) HDL \< 35 mg/dl (females)
  4. Diabetes diagnosis
  5. Hypertension diagnosis
  6. CAD diagnosis

Exclusion Criteria:

* \> 70 years
* Stomach Ulcer History
* Aspirin Allergy
* Anti-coagulation Therapy History
* Clotting Disorder Diagnosis
* Hypersensitivity to non-steroidal anti-inflammatory agents such as Ibuprofen, Aleve, or Motrin
* Hemorrhagic Stroke History
* Current Aspirin use
* 1st Outpatient Visit
The Effectiveness of Bu Zhong Yi Qi Tang in Patients with Myasthenia Gravis

Research Background: According to the Myasthenia Gravis Foundation of America (MGFA, 2015), the estimated prevalence of myasthenia gravis is 14-20 per 100,000 people, with a higher prevalence in young female individuals compared to males. However, as individuals age, especially after the age of 50, the prevalence in males becomes higher than in females. myasthenia gravis patients often experience varying degrees of disability, leading to the need for long-term medical care, medication, and lifestyle adjustments. This also gives rise to subsequent challenges in caregiving, affecting both the patients' families and society.

:This study aims to assess the effectiveness of using a combination of traditional Chinese and Western medicine,to improve the meridian energy and autonomic nervous system function of myasthenia gravis patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with ocular myasthenia by a doctor
* Western medicine prescriptions only take oral Mestinon (Pyrido stigmine Bromide)
* Patients over 20 years old
* Can understand and understand Those who can speak Mandarin or Taiwanese
* those with a clear state of consciousness and no diagnosis of mental illness
* patients and their families who are willing to receive precise integrated treatment of traditional Chinese and Western medicine.

Exclusion Criteria:

* Patients with liver failure or kidney failure
* Allergy symptoms to traditional Chinese medicine, such as skin itching and redness
* Patients with malignant tumors
* Patients currently undergoing radiotherapy and chemotherapy
* Pregnant
* Cardiac rhythm device implementer
Interference of Endurance Training on Strength Development and Neuromuscular Adaptations

This study aims to find out if performing combined strength and endurance exercise in the same program (called concurrent training-CT) leads to similar long-term improvements in neuromuscular function as doing each type of exercise separately. The main questions it seeks to answer are:

Does performing CT result in similar improvements in strength and power as doing just strength training? Does performing CT result in similar improvements in cardiorespiratory fitness as doing just endurance training? Are neuromuscular adaptations similar between CT and just strength training? Researchers will compare the results between three groups: the CT group, the endurance training group (E), and the strength training group (S) to answer these questions.

This study looks at how different types of exercise affect neuromuscular and cardiorespiratory improvements over time. It aims to see how combining strength and endurance training (concurrent training - CT) affects neuromuscular and cardiorespiratory adaptations compared to doing just strength or endurance training. Participants who regularly do both types of exercise will be split into three groups: Concurrent training (CT), endurance training (E), or strength training (S) and will be involved in 11 weeks of supervised training, three days a week:

Endurance training involves 30 minutes of continuous running, three days a week, at an intensity corresponding to the heavy domain (between the first and second ventilatory threshold) Strength training includes weightlifting three days a week, focusing on building both strength and power.

Concurrent training incorporates both strength and endurance exercises in the same session, three days a week, with strength training being executed prior to endurance training.

Researchers will collect data at three time-points during the 11 weeks: before starting the program (Baseline), at the end of week 5 (Week 5), and at the end of the program (Week 11). Measurements include lower-body strength and power, aerobic capacity, nerve evoked responses, and muscle structure if the quadriceps femoris.

Researchers will then compare the CT, E, and S groups at each measurement point to see which type of training elicited the best adaptations for the different neuromuscular and cardiorespiratory outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Active training status (strength and endurance (running) exercise at least 2 times per week over the last three months prior to inclusion in the study)

Exclusion Criteria:

* Active smoking status
* Orthopedic injuries
* On medication
* Known cardiovascular or respiratory disease
Quantra® System With the QStat® Cartridge in Trauma

This is a prospective, single-center, observational study to assess the Quantra QStat System in trauma patients.

This is a prospective, single-center, observational study to assess the performance of the Quantra QStat System in trauma patients.

Eligibility Criteria:
Inclusion Criteria:

* Subject is \> 18 years; Children under the age of 18 are protected by adults under guardianship or by court order.
* Subject is a trauma patient experiencing traumatic injuries requiring a full trauma team response according to site's level 1of trauma team activation criteria.
* Subject, or subject's legally authorized representative (LAR), is willing to provide informed consent, either prospectively or by deferred consent.

Exclusion Criteria

* Subject is pregnant.
* Subject is currently enrolled in a distinct study that might confound the result of the proposed study.
* Subject is not covered by social security.
Fibreoptic Intubation With and Without Sellick´s Maneuver

The goal of this study is to evaluate the effect of Sellick´s Maneuver, a firm pressure on the throat, just below the Adams apple, to occlude the esophagus, in order to prevent aspiration of gastric contents, on intubation with a flexible fiberscope. The result of this study will be participate in the discussion of the importance of Sellick´s Maneuver.

The patients included in this study has volunteered after sufficient information, and must be ASA-class I-II, 18 years or more, and must not have indications for a rapid sequence induction.

The patient will be intubated twice, with and without Sellick´s maneuver. It is blinded to the intubating physician, in which order this pressure is applied.

The outcomes measures will be time of intubation, oxygen saturation before and after intubation and a Cormack Scale graduation of the visibility of the vocal cords. The intubation will be failed, if it cannot be performed under 120 seconds, or if the patients desaturate to 95% or less.

Eligibility Criteria:
Inclusion Criteria:

* ASA I-II
* Informed consent to participate in the study
* Age 18 or older
* Predicted difficult airways

Exclusion Criteria:

* Body mass index more then 35
* Patients with an indication for a rapid sequence induction (reflux, Hiatus herniation, Gastric bypass)