cyrilzakka/clinical-trials huggingface dataset:
Difficult Airway Prediction in Paediatric Anaesthesia

The incidence of difficult airway in paediatric population is up-to date not well described. Difficult airway is connected with significant airway-related morbidity and mortality. The majority of difficult airway in paediatric patients should be predictable. The aim of the study is to evaluate the incidence of difficult airway in paediatric patients scheduled for surgery under general anaesthesia and to test the predictability of the set of prediction tests to reveal the patients with high risk of difficult airway.

At the preanaesthetic visit the paediatric patients will be examined for difficult airway. The Mallampati score, interincisor garp, cervical spine mobility, upper lip bite test and thyromental distance will be measured. The distances will be measured in centimeters and the width of the distal part of the third finger will be measured to obtain the distance according to the patients fingers. The airway management plan will be defined and the incidence of the difficult airway (difficult face mask ventilation - two hand, two operators, desaturation, difficult intubation - Cormack-Leehane 3-4, intubation on 3 and more attempts, difficult laryngeal mask insertion and the incidence of cannot intubate cannot ventilate scenario will be evaluated. The predictability of the test for difficult airway prediction (Cormack-Leehane 3-4, cannot-intubate - cannot ventilate scenario, difficult mask ventilation) will be statistically analyzed.

Eligibility Criteria:
Inclusion Criteria:

- All paediatric patients scheduled for surgery under general anaesthesia On the preanaesthetic examination

Exclusion Criteria:

- Airway already secured by tracheostomy Surgery without securing the airway
Comparison of Two Different Insulin Dose Calculation Algorithms in Type 1 Diabetes

The aim of this study is to compare the impact of carbohydrate counting (CC) method which is standard insulin dose calculation algorithm and food insulin index (FII) method which is a new algorithm on postprandial glucose following a high fat and a high protein meal in adolescent with type 1 diabetes. A randomized, single-blind and crossover trial included 14 adolescents aged 14-18 years with type 1 diabetes. All participants were sent to their homes for 4 consecutive days with a different glycemic index breakfast. The insulin doses of the meals were calculated according to CC and FII methods. Test breakfasts with different GIs and insulin requirements calculated with different algorithms are as follows: High GI calculated by CC (CHGI), low GI calculated by CC (CLGI), high GI calculated by FII (FHGI) and low GI calculated by FII (FLGI).


Eligibility Criteria:
Inclusion Criteria:

* Aged between 14-18 years adolescents
* Type 1 diabetes diagnosed for at least one year
* Performing self-monitoring of blood glucose and doses of insulin at least four times daily
* HbA1c ≤ 9.6% for the last three months
* Negative fasting C-peptide (\<0.1 nmol/L)
* Total daily insulin use of ≥ 0.5 U/kg
* World Health Organization BMI/age z-score of -1 to below 3

Exclusion Criteria:

* Complications of diabetes or other medical conditions including celiac disease
* Treatment with oral hypoglycaemic agents
* Food allergies, intolerances, or eating disorder
* Intestinal malabsorptions
* Delayed gastric emptying
* Viral or bacterial infection
* Physical or mental disability
* Clinical condition related to impaired digestive system such as cystic fibrosis
Safety and Tuberculin Conversion Following BCG Vaccination

The study is an bridging study, observer-blind, randomized, controlled prospective intervention study. The primary objective is evaluate the safety of BCG Vaccine Vial (Bio Farma).

This trial is bridging study, observer blinded, comparative, randomized study. Approximately 220 subjects will be recruited, 110 subjects are the investigational arm and 110 subjects are the active comparator arm.

The objective of the study is to evaluate the safety of BCG Vaccine Vial (Bio Farma), and assess the the local and systemic reactions within 90 days after vaccination in each group, and assess the tuberculin conversion in each group.

Eligibility Criteria:
Inclusion Criteria:

1. Healthy infant aged 0-1 month.
2. Infants born after 37-42 weeks of pregnancy.
3. Infant weighing 2500 gram or more at birth.
4. Father, mother or legally acceptable representative properly informed about the study and having signed the informed consent form.
5. Parents will commit themselves to comply with the instructions of the investigator and with the schedule of the trial.

Exclusion Criteria:

1. Child concomitantly enrolled or scheduled to be enrolled in another trial.
2. Evolving moderate or severe illness, especially infectious diseases or fever (axillary temperature 37.5 celcius degrees).
3. Suspected of allergy to any component of the vaccines.
4. Newborn suspected of congenital or acquired immunodeficiency.
5. Received or plans to receive any treatment likely to alter the immune response intravenous (immunoglobulins, blood-derived products or long term corticotherapy (\> 2 weeks)).
6. Received other vaccination with the exception of OPV and Hepatitis B vaccine.
7. Any abnormality or chronic disease which according to the investigator might interfere with the assessment of the trial objectives.
8. Any skin disease such eczema generalisata other skin infection which makes difficult the assessment of the local reactios.
9. Mothers with HbsAg and HIV positive (by rapid test)
10. Parents planning to move from the study area before the end of study period.
A Health Promotion Intervention for Vulnerable School

The BeE-school (Be Empowered in school) is a cluster-randomised trial that addresses the complexity of the social challenge (vulnerable school-age children). It aims to analyse the effectiveness of the intervention program, based on the promotion of health literacy and lifestyles, specifically on children's: 1-health literacy and infodemic resilience (Aim 1); 2- lifestyles (e.g. dietary intake, 24hmovement behaviour) (Aim 2); 3-overweight and obesity (Aim 3); 4-blood pressure (Aim 4). The project converges multiple disciplines (e.g. public health, informatics, law) and researchers with proven expertise in these fields to provide comprehensive and innovative answers. 478 children (6 schools) aged 6-12years old will participate in this cluster-randomised trial, having schools as the unit of randomisation, assigned into intervention (239-3schools) and the control arm (239 - 3 schools). This project will perform a social listening (online and offline) and bottom-up approach to tackling NCDs, focusing on health literacy and health promotion and recognising children's systems in daily life (e.g. family, teachers). Stakeholders' involvement goes far beyond a merely consultative approach; the researchers are committed to a genuine codevelopment process. Data collection includes sociodemographics, health literacy and infodemic resilience, dietary intake and children's 24-h movement behaviour (e.g. accelerometry), anthropometry (e.g. weight, height and waist circumference) and blood pressure. Data collection will occur at baseline and after the intervention (follow-up, 6 months after the beginning of the intervention). Expected outputs and outcomes include the creation of a model for characterising NCDs and health topics based on artificial intelligence techniques (e.g. deep learning, and social network analysis methods); improved health literacy and infodemic resilience of children, families and teachers; enhanced children's lifestyles (e.g. dietary intake, 24-h movement behaviour); reduction of NCDs' physical risk factors (e.g. overweight, raised blood pressure); feasible intervention program about health promotion and NCDs' prevention for school-aged children with vulnerabilities, and advocacy- policies about health promotion and NCDs' prevention.


Eligibility Criteria:
Inclusion Criteria:

* Children from TEIP schools
* Ages between 5 to 12 years old

Exclusion Criteria:

* Children/families who don't speak/understand Portuguese
Association Between Phthalates Exposure and Renal Function Impairment in TYpe 2 Diabetes

The global incidence of diabetic nephropathy (DN) is increasing, with no appreciable reduction in the percent of patients progressing toward end stage renal disease (ESRD) and dialysis (Tuttle et al, 2014, Winocour et al, 2018). Therefore, identification of modifiable risk factors and early biomarkers of progressive decline in kidney function is an urgent clinical need. Phthalates are environmental and dietary contaminants with a various array of use that are identified in many consumer and industrial products; among them, di-(2-ethylhexyl) phthalate (DEHP) and its metabolites (mono 2-ethylhexyl phthalate (MEHP), 5OH-MEHP (MEHHP) and 5oxo-MEHP (MEOHP)) are widely used (Kato et al 2004, Braun et al, 2013). They partially distribute to the human tissues and their urinary and serum levels are directly related; therefore, urinary concentration of phthalates is commonly used as proxy of their exposure in humans (Kato et al 2004).

While the association between phthalates exposure and development of T2D is currently being explored (Dong et al 2017, Dales et al, 2018), little is known about their role in DN. Recent observations show that DEHP and its metabolites are associated with a higher prevalence of low-grade albuminuria and in children exposed to higher phthalates concentrations (Trasande et al, 2014, Wu et al, 2018), however such association has yet to be verified in adults. The environmental ubiquity of the phthalates enhances the importance of investigating the potential relation between their exposure and different degrees of renal function. (Kato et al 2004, Kataria et al, 2015).

Given this premise, the investigators will explore this potential association in a population of subjects with T2D consecutively referring to the outpatient diabetes clinic in Santa Chiara Hospital, Pisa, enrolled on a volunteer basis. During their routine visit at Santa Chiara Hospital outpatient diabetes clinic participants will provide the results of blood tests prescribed as per standard clinical practice along with a first morning, overnight fasting, urine sample collected in a phthalates-free container.

The investigators will record the participants' clinical history, physical examination and anthropometric measurements, will measure their renal function, evaluated by eGFR (calculated with the CDK-EPI formula), albumin excretion, fasting glucose, HbA1c%, and the exposure to phthalates, assessed by total concentrations of MEHP, MEOHP, MEHHP and adjusted for urinary creatinine. In this way, the investigators aim to point out the relationship of urinary phthalates with higher degrees of albuminuria and/or lower eGFR after adjustment for all potential confounders, including therapies.


Eligibility Criteria:
Inclusion Criteria:

Age 18-85 years, T2D diagnosis, T2D duration \>6 months,

Exclusion Criteria:

occurring acute clinical conditions, eGFR \<15 ml/min/1.73m2, BMI \> 40 Kg/m2.
PT-CY With or Without Low-dose ATG for Lymphoid Malignancies Undergoing Allo-HSCT

All patients received Flu-BU-VP16 as myeloablative conditioning followed by cyclophosphamide (D+3 and +4) and subsequent tacrolimus. For patients with unrelated or haplo-donor received low-dose ATG at Day +15.

For patients with high-risk lymphoid malignancies, patients will undergo allo-HSCT from HLA matched sibling, unrelated (9\~10/10) donor or hallo-identical donors. For all patients will receive myeloablative conditioning with 5-day fludarabine, 2-day VP-16 and 3-day busulifan. For prophylaxis graft versus host disease (GVHD), patients will receive cyclophosphamide 50mg/kg daily on D+3 and +4 with subsequent tacrolimus starting at D+5. For patients receiving HSCT from unrelated or haplo-donor, low-dose ATG 2.5mg/kg will be given on Day +15.

Eligibility Criteria:
Inclusion Criteria:

* patients with lymphoid malignancies: CR1 or CR2 for acute lymphoblastic leukemia; T cell lymphoma (any CR/PR); B cell lymphoma (PR1 or CR2), hodgkin's disease (CR2 or beyond), Sezary syndrome
* patients with HLA matched sibling, unrelated (HLA 9\~10/10 matched) or haplo-identical donor

Exclusion Criteria:

* patients with active infection
* patients with abnormal liver function damage: ALT/AST above 2X normal range
* patients with abnormal renal function damage Scr\>160µmol/L;
* patients with insufficient pulmonary function (FEV1，FVC，DLCO\<50%）and heart failure or with EF \<50%)
* patients with mental instability
* unwilling to give inform consent
Correlation of Social Media Usage With Physical Activity and Academic Performance in Children

Social media are internet-based applications that allow users to exchange messages or user-generated content for the purposes of social connection, entertainment, or education. WhatsApp, Skype, Facebook, Instagram, Telegram, and Twitter are a few of the most well-known and frequently used virtual social networks. In young children and school-age populations have concentrated on the correlation between watching television and playing video games and academic achievement, demonstrating a detrimental impact on physical health. Children who watch television for more than two hours a day tend to perform worse academically and engage in less physical activity.

The study will be conducted as a non-probability convenience sampling with the objective of Social Media Usage on Physical Activity and Academic Performance in Young School-Age Individuals. Patient age range from 10 to 16 years, both genders.

Sample size is 289 students of private and government schools. Collaborate with schools within the selected age range and obtain permission for the study. The patients' assessment includes the use social media addiction scale, Academic performance questionnaire, SAMU DIS-FIT Battery. Data will be analyzed by SPSS version 26. Descriptive statistics will be checked by using frequency, percentage, mean and standard deviation of the variables. Normality of the collected data will be checked by using SPSS version 26. If p value will be more that 0.05 will apply parametric test. if it is less than 0.05 will apply non parametric test. Pearson correlation "r will be applied for parametric data and Spearmon RAO will be used for non-parametric data

Eligibility Criteria:
Inclusion Criteria:• Age of the participant will be 10 to 16 years.(3)

* Male and female both will be included.(25)
* Constantly using screen time with minimum 40 minutes per day.(5)
* Healthy and physical fit participant will be included. • Regular and enrolled students of public and private schools

Exclusion Criteria:

Children with disabilities that are limited in their ability to understand the instructions or the performance of the activities (Cognitive impairment etc.)

* Students with any significant past medical history or surgical history will not be included in this study
The Effect of 7 Days of Letrozole Pretreatment Combined With Misoprostol on the Placental and Decidual Tissues

The present study aims at studying the effect of letrozole in early pregnancy in placenta and decidua including the progesterone receptor and the apoptotic factors.

Twenty healthy subjects requesting legal surgical abortion up to 63 days gestation will be recruited for this study. They will be randomized to receive either placebo tablets or letrozole 10 mg daily for 7 days before suction evacuation. Suction evacuates which include the placenta and some decidua collected by the procedure in these 20 subjects will be used for the laboratory studies.

Eligibility Criteria:
Inclusion Criteria:

* The gestational age should be up to 63 days. An ultrasound assessment would be performed to confirm the gestation.
* The woman is willing and able to participate after the study has been explained
* Age \>18 years old

Exclusion Criteria:

* Criteria for prospective exclusion

Any indication of past or present ill health will be considered a contraindication for recruitment to the study. In particular, subjects should not be recruited if any of the following conditions is present:

1. multiple pregnancies
2. uterine fibroids
3. any significant medical disorder
4. intrauterine contraceptive device in situ
5. contra-indications to the use of letrozole or misoprostol

   * Criteria for exclusion from a secondary analysis

Situation in which subjects who have been formally admitted to the study could be excluded from a secondary analysis include:

1. the use of drugs other than those prescribed by the investigator for the treatment of possible therapy-related side-effects especially drugs with prostaglandin synthetase inhibitory activity such as salicylates, indomethacin or mefenamic acid
2. any violation of the study protocol
3. essential data missing from the subject's records making it impossible to judge the treatment outcome
Intraoperative Cerebral and Renal Tissue Oxygen Saturation and Pediatric Living Donor Liver Transplantation Prognosis.

This rSO2 study is a prospective clinical study. The purpose of the rSO2 study is to investigate whether there is a correlation between the intraoperative cerebral and renal tissue oxygen saturation and the incidence of developmental and socioemotional delay after living donor liver transplantation for children. This study will also investigate whether intraoperative cerebral and renal tissue oxygen saturation are related to postoperative complications.

There is high incidence of developmental and socioemotional delay and postoperative complications in pediatric living donor liver transplantation patients. In this prospective observational clinical study, the investigators aim to investigate the correlation between the intraoperative cerebral and renal tissue oxygen saturation and the incidence of developmental and socioemotional delay and postoperative complications. This study will enroll patients aged from 6 to 36 months old who are scheduled for elective standard living-donor liver transplantation and have signed informed consent before the surgery.

Eligibility Criteria:
Inclusion Criteria:

* Pediatric patients (6 months\< the Moon's age \<36 months) who will receive standard living-donor liver transplantation (LDLT) in Renji Hospital.

Exclusion Criteria:

* Forehead skin infection, A history of liver transplantation, Multivisceral transplantation, Refused to participate the study
Anxiety and Depression Among Gendarmes Posted to French Guiana

This is a mixed-method, single-center study involving two concurrent phases: a quantitative phase with an anonymous self-administered questionnaires, and a qualitative phase with individual contextual interviews and a focus group. The hypothesis underlying this study is that isolated postings are a risk factor for anxiety-depressive disorders. The aim of this study is to provide new information to help propose targeted prevention and health promotion measures.


Eligibility Criteria:
Inclusion Criteria:

* Gendarme in active position
* Age over 18
* Assignment in French Guiana for more than 6 months at the time of the study
* Not opting for study participation

Exclusion Criteria:

* Previously diagnosed psychiatric condition
* People with a reading/writing disability in the French language
* Major incapacity
Effects of Lower Limb Concentric Versus Eccentric Dynamic Resistance Training on Agility and Speed in Badminton Players

With an average heart rate (HR) of more than 90% of the player's maximal HR, football is extremely taxing. The sporadic movements that occur throughout a game place a strain on the anaerobic and aerobic systems, accounting for roughly 30% of the latter's workload and 60% of the former. The capacity to shift directions and accelerate or decelerate on the court in order to make accurate shots and perform better is what determines footwork performance. Plyometric Training is a favored training technique for raising COD performance since it has a reputation for being a simple, quick, and efficient method of training. The core practice of combining resistance conditioning exercises with a dynamic warm-up can improve power output in badminton and create a post-activation performance enhancement (PAPE) impact. According to random sampling and sample size calculated by open epi tool, a total of 68 badminton players will be obtained from the badminton club of a Crescent sports club and Al-Fatah Sports Complex, Faisalabad. They will be divided into group A and group B according to the form of random sampling. Baseline markers for agility and speed will be taken before the start of the training and after the completion of training program. Group A will be engaged in a specially designed 30-minute concentric lower limb training program (squats, lunges and leg extensions) conducted by the researchers, before a 90-minute ordinary badminton training session conducted by the coach, 2 days per week for 8 weeks. Group B will be engaged in a specially designed 30-minute eccentric lower limb training program (wall sit, sitting straddle single leg and full squat) conducted by the researchers, before a 90-minute ordinary badminton training session conducted by the same coach, 2 days per week for 8 weeks.

The aim of the study is to find out the effects of concentric and eccentric dynamic resistance training on agility and speed in badminton players

Eligibility Criteria:
Inclusion Criteria:

* Age 18-35 (12)
* Both male \& female players
* Healthy players/no injuries (8)
* No severe injuries during the last six months (16)
* Player with minimum 1-year experience of badminton (17)

Exclusion Criteria:

* Serious musculoskeletal injuries/disorders(8)
* Participants who will be unable to complete concentric/eccentric dynamic resistance training
* Who will be unwilling to complete six-weeks of training and tests