cyrilzakka/clinical-trials huggingface dataset:
Comparing Calories at Fast Food Restaurants

Rating systems are intended to guide consumer choices. This project will determine if a previously developed scale that evaluates the "healthiness" of a restaurant is correlated with the actual choices consumers make when they patronize the restaurants. The study will also assess whether a restaurant marketed as "healthy" (Subway) rates higher on this scale than another restaurant that makes no such claims (McDonald's). Finally, the investigators will compare the calorie purchases from these two restaurants among youths and their families who eat at each of the restaurants.


Eligibility Criteria:
Inclusion Criteria:

* 12-21 Year Olds that live in local area
* Like to eat at Subway and McDonald's
Grip Effects of Power Ball in Children

A broad definition of visual impairment includes a wide continuum of visual function loss. Aspects of visual function include visual acuity, which is the capacity to resolve detail, and accommodation (capacity to concentrate), field of vision (the area that may be seen), colour perception, and light sensitivity. A child with cerebral blindness can nevertheless be able to perceive motion. There are numerous sources of prevalence information, each of which has drawbacks. One of the fundamental pillars of the major worldwide prevention of blindness project, VISION 2020 the Right to Sight, is the reduction of visual impairment and blindness in children in resource-poor nations. Refraction and poor vision services aid visually impaired children, especially those with genetic or congenital ocular defects and enable vision improvement.

Visual impairment is a broad term that describes a wide continuum of loss in visual function. There are many aspects of visual function e.g., visual acuity(ability to resolve detail),accommodation (ability to focus), field of vision (area which can be seen), colour vision and adapt ability to light. A child with cerebral blindness may have intact perception of movement. Prevalence data can be obtained from a variety of different sources, each of which has limitations. Reducing visual impairment and blindness in children in resource-poor countries is one of the key components of the major global prevention of blindness initiative, VISION 2020 the Right to Sight. Visually impaired children especially with hereditary /congenital ocular anomalies benefit from refraction and low vision services which facilitate vision enhancement and inclusive education. Pediatricians have a key role in early detection and multidisciplinary management to minimise the impact of visual impairment (VI) in childhood.Visually impaired children especially with hereditary /congenital ocular anomalies benefit from refraction and low vision services which facilitate vision enhancement and inclusive Powerball® is such a market existing device that can be used for wrist rehabilitation and also as a sports aid for strengthening the wrist. The Powerball acts as an eccentric exercise tool, generating forces in different directions and thus causing stimulation of the forearm, hand, and wrist musculature. The tools used will be handheld dynamometer and pegboard test. Study will be conducted on Twenty eight patients in two Groups. .Group A will be Control Group that will be provided with conventional physiotherapy (isometric hand grip training exercises) and Group B will be Experimental Group that Conventional treatment with power ball training. Data will be analyzed using spss 22.0

Eligibility Criteria:
Inclusion Criteria:

* Age ranging from 8 to 14 years,
* Both genders (male /female)

Exclusion Criteria:

* Serious medical conditions such as cardiac disease, diabetes, or uncontrolled seizures
* Significant shoulder, elbow, or
* wrist joint contractures preventing grip movement of the hand and fingers.
* Unable to follow the command
* Orthopedic surgery, neurological surgery
The Efficacy and Safety of Ornithine Aspartic Acid Granules in NAFLD Against Silymarin Capsules

This is a multicenter, randomized, double-blind, double-dummy, and positive control clinic trial which explores the efficacy and safety of ornithine aspartate granules in the treatment of non-alcoholic fatty liver disease against silymarin capsules. The hypothesis is that the ornithine aspartate granules have similar or better efficacy than the silymarin capsules.


Eligibility Criteria:
Inclusion Criteria:

* 1. Consistent with NAFLD diagnosis criteria, and during previous one month, the B-mode ultrasonography showed diffuse fatty liver and Fibroscan test showed that CAP value \> 248 db/m;
* 2. During previous one month, serum ALT level was higher than 1.5 times the upper limit of normal.
* 3. BMI is not more than 30 kg/m2.
* 4. Voluntary to participate in the research and signed a written informed consent to comply with the trial protocol.

Exclusion Criteria:

* 1. Hereditary metabolic or autoimmune liver disease, hepatotropic and non-hepatotropic virus infection, drug/toxic/alcoholic/biliary liver injury, or any end-stage liver disease; fatty liver disease caused by one of the following reasons: total parenteral nutrition, inflammatory bowel disease, hypothyroidism, Cushing's syndrome, beta-lipoprotein deficiency and some insulin resistance (IR) related syndromes (lipid atrophic diabetes, Mauriac syndrome);
* 2. Hepatic or extrahepatic malignant tumors;
* 3. Severe heart failure or renal failure (serum creatinine \> 3mg/100mL);
* 4. Allergic constitution, or allergic to amino acid drugs or to ornithine aspartate and its constituents or to silymarin;
* 5. ALT or γ-glutamyl transpeptidase (γ-GT) are greater than 5 times the upper limit of normal, or total bilirubin (TBIL) \> 51 umol/L.;
* 6. Confirmed liver cirrhosis or Fibroscan test showed E value \> 12.5 kilopascal (KPa);
* 7. Triglyceride \> 5.6mmol/L;
* 8. Diabetes diagnosed for more than 5 years, combined with current insulin therapy or taking hypoglycemic drugs with poorly controlled condition (HbA1c \> 9%).
* 9. Women who are pregnant, nursing or preparing for pregnancy;
* 10. Suspected or confirmed excessive drinking (equivalent alcohol amount: male, \> 40g/d; female, \> 20g/d), or history of drug abuse;
* 11. Combined use of drugs with liver protection and anti-inflammatory effects, as well as any Chinese patent medicine, Chinese herbal medicine, or health products that may have liver protection or liver damage effects;
* 12. Taking weight-loss drugs or receiving weight-loss treatment;
* 13. Situations of inappropriate participation judged by researchers.
Southwest Harvest for Health Vegetable Gardening Intervention

"Harvest for Health" is a home-based vegetable gardening intervention that pairs cancer survivors with certified master gardeners (MGs) from the Cooperative Extension System, the education and outreach arm of land-grant universities nationwide.

Few lifestyle behavior change interventions have been successfully translated into practice. Addressing this research-to-practice gap is a significant research and public health priority. "Harvest for Health" is a home-based vegetable gardening intervention that pairs cancer survivors with certified Master Gardeners from the Cooperative Extension System. The parent study was started at the University of Alabama at Birmingham and is currently being conducted throughout the entire state of Alabama. Preliminary findings suggest that this intervention increases vegetable consumption and physical activity, and improves physical functioning and health-related quality of life. We propose a feasibility study to adapt this promising program to the multi-cultural population of cancer survivors and for the local context (physical, social, and cultural environment) of New Mexico. We will then implement the adapted program, "Southwest Harvest for Health" and evaluate feasibility, acceptability, and fidelity. The adaptation phase is a critical first step towards widespread dissemination, implementation, and scale-up of an evidence-based intervention.

Eligibility Criteria:
Inclusion Criteria:

* Age 50 years or older
* Residing in Bernalillo or Sandoval County, New Mexico
* Diagnosed with an invasive cancer (any type)
* Completed primary treatment (surgery, radiation, chemotherapy)(note: endocrine therapy is allowed)
* Able to read, speak, and understand English (The future larger trial will include Spanish-Speaking participants)
* Not told by a physician to limit physical activity and no pre-existing medical condition(s) that would preclude home gardening, e.g., severe orthopedic conditions, hip or knee replacement surgery within 6 months), end-stage renal disease, paralysis, dementia, blindness, unstable angina, untreated stage 3 hypertension, or recent history of myocardial infarction, congestive heart failure, or pulmonary conditions that required oxygen or hospitalization within 6 months.
* Currently not adhering to the recommended number of fruit and vegetable servings per day (consuming fewer than 5 servings of vegetables and fruits/day and not meeting the recommended guidelines for moderate-to-vigorous physical activity (\< 150 minutes/week)
* Reside in a location that can accommodate a 4' x 8' raised garden bed or 4 (29" x 14") garden containers, or adequate (at least 4 hours) of sunlight per day and have access to running water
* No existing or recent (within the past year) experience with vegetable gardening
* Able to participate in the 10-month intervention (all three seasonal gardens; from mid-February through early November 2020)
Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major Depression

Researchers are trying to find out if a Stress Management and Resiliency Training (SMART-D) therapy will help with major depression treatment.


Eligibility Criteria:
Inclusion Criteria:

* Participants will be enrolled for this study from patients attending the Mayo Clinic Depression Center, Mayo Clinic Family Medicine clinics, Behavioral Health and Primary Care Clinic at Mayo Clinic Health System, Austin, MN, with a diagnosis of major depression, in partial or near remission with PHQ-9 scores ≤14
* Participants will be required to be between 25 and 80 years old
* Able to speak English
* Able to provide written informed consent to participate in the study
* Participants must have DSM-V diagnostic confirmation of major depressive disorder (MDD) (American Psychiatric Association 2013).
* Participants will continue taking any prescribed medications from their clinical treatment team.
* Participants with co-morbid secondary diagnoses of persistent depressive disorder and generalized anxiety disorders will be included in the study.
* Participants must consent to audio recording of random group sessions which will be disclosed at the final study session.

Exclusion Criteria:

* Participants with bipolar disorder, active psychosis, active suicidal ideations, and active substance abuse meeting criteria for substance use disorders except nicotine, obsessive compulsive disorder, active panic disorder with agoraphobia or other phobic disorder, active posttraumatic stress disorder, active severe personality disorders will be excluded.
* Pregnant women - because of time duration of the study.
The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery.

Background: Intestinal resections are commonly performed in the pediatric population. Perfusion of the bowel is one of the most important factors determining the viability of an intestinal anastomosis. Up to date, no ideal method to assess intestinal perfusion has proven its superiority.

Objectives:

Primary: The aim of this study is to establish the feasibility and impact of the use of indocyanine green technology on intestinal resection margins during elective and emergency pediatric surgeries.

Secondary: The secondary outcomes of interest include collection of adverse events and difficulties encountered with the use of the indocyanine green (ICG) technology. Postoperative surgical complications will also be recorded.

Study Design: An open observational clinical study will be performed by using a clinical drug (indocyanine green) and medical device (SPY Fluorescence Imaging) to assess intraoperatively intestinal perfusion in a specific pediatric population.


Eligibility Criteria:
Inclusion Criteria:

* Patients \< 16 years old
* Admitted between September 2019 and September 2020
* Patients undergoing a surgery at CHUSJ
* Any diagnosis requiring intra-abdominal intestinal resection (including stoma reversal)
* Written informed consent form from the parents or legal guardian

Exclusion Criteria:

* Patients \> 16 years old
* Patients with known allergy or sensitivity to iodine
* Patients with known kidney or liver failure
* Patients with known severe cardiac or pulmonary diseases
* Informed consent unobtained or impossible due to refusal of parents, language barrier, or diminished comprehension
Intrathecal Pethidine Plus Dexamethasone for Distal Lower Orthopedic Surgeries

Bupivacaine is commonly used as a sole agent for spinal anesthesia unlike pethidine. Pethidine (meperidine) is a unique opioid. In addition to its analgesic activity, it also has significant local anesthetic activity. This property enables it to be used as the sole agent for spinal anesthesia

pethidine compared favorably with bupivacaine as the sole anesthetic agent, providing excellent conditions for lower abdominal and pelvic surgery. Some studies showed that intrathecal pethidine has short motor recovery and prolonged postoperative analgesia in comparison to intrathecal bupivacaine. The side effects of pethidine in spinal anesthesia are pruritus nausea, vomiting and respiratory depression. A dose of 1mg/kg intrathecal pethidine provides surgical anesthesia .However, its effects are not widely available in recent studies.

Dexamethasone is used as an adjuvant to local anesthetic during spinal anesthesia and other techniques of regional anesthesia, it reduces pain and prolongs the duration of post-operative analgesia. It was shown that intrathecal dexamethasone reduces the complications of spinal anesthesia such as arterial hypotension, nausea, vomiting and shivering. The investigators suppose that addition of intrathecal dexamethasone to pethidine may be a better alternative to intrathecal bupivacaine during spinal anesthesia for lower extremity orthopedic surgery with better outcome and less side effects

Eligibility Criteria:
Inclusion Criteria:

* Patient acceptance.
* Patients scheduled for lower extremity orthopedic surgery
* Both sex
* Patient's age \>18 years.
* Patients with American Society of Anaesthesia (ASA)physical status I, II.

Exclusion Criteria:

* Patient's age ≤18 years.
* Uncooperative patients and patients with psychological problems.
* Patients with contraindications to spinal anesthesia.
* Patients with contraindications to bupivacaine or dexamethasone or pethidine.
* Patients with ASA physical status III and IV.
* Morbid obesity (BMI \>35).
Advanced Glaucoma Intervention Study (AGIS)

To assess the long-range outcomes of sequences of interventions involving trabeculectomy and argon laser trabeculoplasty in eyes that have failed initial medical treatment for glaucoma.

In advanced glaucoma, medication alone no longer reduces intraocular pressure adequately, and the eye has field defects. Before 1980, some type of filtering surgery, such as trabeculectomy, was the usual method of intervention. Since then, laser trabeculoplasty has become a popular alternative. Sometimes the first intervention chosen succeeds in controlling pressure for many years; at other times, the success lasts only a few weeks or months. Because success is limited, some patients, over time, need to undergo a sequence of surgical interventions. Little is known about which sequence gives the best long-range outcome.

The Advanced Glaucoma Intervention Study (AGIS) is designed to provide a comprehensive assessment of the long-range outcomes of medical and surgical management in advanced glaucoma. The study uses visual function status to compare two intervention sequences in managing the disease.

Eligible eyes are randomly assigned to one of two intervention sequences: (1) trabeculectomy, followed by argon laser trabeculoplasty (ALT) should trabeculectomy fail, followed by a second trabeculectomy should ALT fail; or (2) ALT, followed by trabeculectomy should ALT fail, followed by another trabeculectomy should the first trabeculectomy fail. Antifibrotic agents may be used as an adjunct to trabeculectomy, but only in eyes with a previous history of invasive surgery. Eyes that fail the entire assigned sequence of interventions are managed at the discretion of the AGIS physician in collaboration with the patient.

Interventions are supplemented with medical treatment as needed. A total of 789 eyes with advanced glaucoma have been enrolled. All patients are being followed under a standardized protocol for a minimum of 5 years to determine degree of visual function loss, failure rates of interventions, rates of complications, and need for supplemental therapy.

After the initial intervention, followup examinations are scheduled at 1 week, 4 weeks, 3 months, 6 months, and every 6 months thereafter. After second and third interventions, followup examinations are scheduled at 1 and 4 weeks. Additional visits are scheduled as necessary for the management of the disease.

The primary outcome variable in AGIS is average percent of eyes with decrease of vision, where decrease of vision is a substantial decline of either visual field or visual acuity attributable to the effect of glaucoma. Secondary outcome variables include sustained decrease of vision, failure of interventions, number of prescribed glaucoma medications, and level of intraocular pressure. An ancillary study is assessing filtering bleb encapsulation.

Eligibility Criteria:
Men and women between the ages of 35 and 80 with open-angle glaucoma that was not successfully controlled by medication were eligible for enrollment.
Study Comparing Piperacillin-tazobactam Versus Piperacillin-tazobactam Plus Glycopeptide in Neutropenic Patients

The aim of this study is to compare the efficacy and tolerance of piperacillin-tazobactam versus piperacillin-tazobactam plus glycopeptide as initial empiric antibiotic treatment for fever in neutropenic patients. Study of consecutive cohorts(2). First the patients will be included in the monotherapy branch until completing the predicted number of cases. When this happens, the Coordinating Center will communicate it to the participant centers and from then the patients will be included in the combined therapy.


Eligibility Criteria:
Inclusion Criteria:

* Patients with hematological malignancy or those who had undergone stem cell transplantation for neoplastic disease.
* Fever (\>38ºC)
* Neutropenia (absolute neutrophil count \< 500 or \< 1000 anticipated to fall below 500 cells within 24-48 hours).

Exclusion Criteria:

* Known allergy to any of the antibiotics used in this trial
* A high probability of death within 48 hours
DHA Supplementation and Pregnancy Outcome

Supplementation with DHA during pregnancy will increase gestational length and improve cognitive development.

This was a trial of supplementation with DHA during pregnancy to increase gestational length. Subjects were provided with 300 mg, 600 mg or placebo (olive oil) in a randomized design from week 24-26 of pregnancy until delivery. Gestational age, birth weight and birth length data were collected and infants growth at 2 and 4 months and cognitive development at 4 months and 1 year were measured.

Eligibility Criteria:
Inclusion Criteria:

* singleton pregnancy
* 18 years of age or older

Exclusion Criteria:

* cervical incompetence
* presence of cervical cerclage
* placenta previa
* intrauterine infection
* known substance abuse
* multiple fetuses
* current pre-eclampsia
* preexisting diabetes
Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP patientsChinese?

The effect of baclofen (GABAB agonist), diltiazem (muscle relaxant) and placebo will be compared in a double-blinded randomized study for the treatment of NCCP. Cerebral cortical, brainstem and spinal evoked potentials before and after treatment will be evaluated. Results of this study will shed lights on pathogenesis and treatment of NCCP in Chinese.We hypothesize that Baclofen alleviates visceral hyperalgesia in NCCP patients by suppressing afferent sensory pathway.


Eligibility Criteria:
Inclusion Criteria:

* Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy
* Age between 18-70
* Gastroesophageal reflux disease
* Psychiatric illness
* Cerebrovascular accident
* Active peptic ulceration
* Heart failure or cardiac bradyarrhythmia
* Epilepsy
* Pregnancy or lactating female
* Previous hypersensitivity to muscle relaxant
Verification of the Root Form Classification of Impacted Lower Third Molars

A clinical study will be conducted to verify the reliability of the root form classification of impacted lower third molars that was put by Abu-Mostafa N (2023) The root forms of partially or fully impacted lower third molars will be classified pre-operatively based on panoramic radiograph, then clinically after extraction, and the identified root classifications will be compared.

According to Abu-Mostafa N, the roots of impacted lower third molars are classified into two types: Fused roots and separated roots. Both have different forms:

Fused roots forms: Straight, Curved distal, Curved mesial, and S-shaped.

Separated roots forms: Straight, Both roots are curved distal, Both roots are curved mesial, Joined roots, One root is straight and one is curved, and More than two roots.

A panoramic radiograph will be taken before extraction, then the roots will be classified by two Oral biologist and Oral and Maxillofacial Surgeon individually. After surgical extraction of the third molar, the roots will be examined clinically and classified according to the same classification.

The two pre-extraction radiographic classifications will be compared together, and then they will be compared with the clinical classification to check if there is a discrepancy.

The surgical extraction procedure:

Local anesthesia will be achieved by inferior alveolar nerve block and buccal infiltration using Lidocaine 2% with Epinephrine 1:100,000. A flap with a distobuccal releasing incision will be done. The bone reduction will be performed by a low-speed surgical handpiece under irrigation with normal saline. Root separation is done of required for the third molars with separated root forms. The tooth will be luxated by straight elevators and then extracted.

The evaluation results will be categorized to:

* Agreement: The two pre-extraction radiographic evaluations and the clinical evaluations are similar
* Discrepancy 1: One pre-extraction radiographic evaluation and the clinical evaluations are similar, but the other radiographic evaluation differs.
* Discrepancy 2: the two pre-extraction radiographic evaluations are similar, but the clinical evaluation differs.
* Disagreement: The three evaluations are different

The results will be analyzed regarding frequencies and association of each category with root forms

Eligibility Criteria:
Inclusion Criteria:

Patients with impacted lower third molars who visit Riyadh Elm University" hospital and have lower third molars which are diagnosed clinically and radiographically as partially or fully impacted. The roots of these third molars have to be fully formed.

Exclusion Criteria:

incomplete apex formation and root resorption