cyrilzakka/clinical-trials huggingface dataset:
Effectiveness of EMDR in Borderline Personality Disorder: a RCT Single-blind Study in a Real-world Care Setting

Borderline personality disorder (BPD) is a severe mental disorder characterized by four major symptomatological domains: interpersonal instability, perceptive and identity disorders, emotional and behavioural dysregulation. Considering a multifactorial etiological model, it has been suggested that the interaction between behavioral, environmental and genetic factors may promote the development of BPD. Early life stress events (ELS) in childhood and adolescence are highly prevalent in this population and constitute an environmental risk factor for the development of BPD. This correlates with the fact that Post-traumatic Stress Disorder (PTSD) is frequently comorbid in BPD leading to more severe symptoms and worse psychosocial functioning. At the therapeutic level, the treatment of BPD is an open challenge as psychotherapeutic interventions are of limited effectiveness and characterized by high drop-out rates. Eye Movement Desensitization and Reprocessing (EMDR) is the gold standard for treating PTSD. However, scientific evidence on the application of EMDR in patients with BPD is limited. This study aims to assess the feasibility and effectiveness of an EMDR protocol on the nuclear symptomatology of BPD (emotional and behavioral dysregulation) in a group of DBP patients with/without PTSD comorbidity, through a systematic assessment of the peculiar dimensions of the disorder. The basic hypothesis is that EMDR, through a short-term intervention, can act both on the traumatic PTSD-like experiences reported by patients and on the clinical manifestations peculiar to DBP, in particular by improving the emotional regulation capacity of patients with BPD.


Eligibility Criteria:
Inclusion Criteria:

* Patients must be over 18 years old
* A current diagnosis of PBD according to the DSM-5 was confirmed using the SCID-5-CV and SCID-5-PD diagnostic scale

Exclusion Criteria:

* Suicidal ideation in the last 3 months (suicidal thoughts active intentionally but without specific planning or suicidal thoughts active with planning and intentionality)
* Intellectual disability
* Any active disturbance from use of substances or alcohol
* Any other diagnosis of Axis I, except for Depressive Disorders, Anxious Spectrum Disorders, Obsessive-Compulsive Disorder.
Serum Proteomics Analysis for Sepsis

Serum proteomics is a very useful tool to identify various disease. The purpose of the present study was to find differential proteins among patient with normal, SIRS, sepsis, severe sepsis, death and to screen potential biomarkers for their dynamic changes. Serum proteins were identified by iTRAQ labeling and LC-MS/MS. The bioinformatics analysis was performed with the Mascot software and the International Protein Index (IPI) and the Gene Ontology (GO) Database and KEGG pathway Database. The differentially expressed proteins were verified by Western blot by another sample collected from clinical.


Eligibility Criteria:
Inclusion Criteria:

* Male and female aged 18 years old and over;
* clinically confirmed infection;
* fulfilled at least two criteria of systemic inflammatory response syndrome
* (a) core temperature higher than 38 °C or lower than 36 °C
* (b)respiratory rate above 20/min, or PCO2 below 32 mmHg
* (c) pulse rate above 90/min, and
* (d) white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands.

Exclusion Criteria:

* younger than 18 years of age;
* acquired immunodeficiency syndrome;
* reduced polymorphonuclear granulocyte counts (\< 500 μL-1);
* died within 24h after admission into the ICU, or refused to participate in the study, or declined treatment during the period of observation.
Effect of Subarachnoid Block and Femoropopliteal Block to Limb Perfusion in PAD Patients

This pilot study investigates the effects of femoropopliteal and subarachnoid nerve blocks on tissue oxygen saturation (StO2) in patients with Peripheral Arterial Disease (PAD) during lower limb surgeries. Using Near-Infrared Spectroscopy (NIRS), the study compares changes in StO2 post-block. Although no significant differences were found between the two block types at most time points, subarachnoid blocks generally led to higher StO2 increases compared to femoropopliteal blocks, with significant differences observed at 5 and 15 minutes post-block.

This pilot study explored the impact of femoropopliteal and subarachnoid nerve blocks on tissue oxygen saturation (StO2) in patients with Peripheral Arterial Disease (PAD) during lower limb surgeries, using Near-Infrared Spectroscopy (NIRS) for non-invasive monitoring. The study compared StO2 changes at baseline, 5, 15, and 30 minutes post-block in two groups: those receiving femoropopliteal blocks and those receiving subarachnoid blocks.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-80 years old who are scheduled to undergo lower limb debridement surgery.
* Diagnosis of Peripheral Arterial Disease (PAD).
* Lesion located below the knee.

Exclusion Criteria:

* Consuming opioids before hospital admission.
* Having allergies to the medications used in the study.
* Presence of infection at the injection site.
Evaluation of ClearLLab Leukemia and Lymphoma Panels

Multi-center study of specimens from subjects presenting to the flow cytometry laboratory as part of their standard of care for hematological diseases work-up.

Multi-center study of specimens from subjects presenting for flow cytometry immunophenotyping as part of their standard of care for hematological diseases work-up. Residual specimens will be tested using the ClearLLab Panels to determine the presence or absence of an abnormal phenotype and compare results to clinical impression (hematological malignancy or non-malignancy).

Eligibility Criteria:
Inclusion Criteria:

* Residual samples from patients with hematological abnormalities being evaluated by Flow Cytometry for the presence or absence of an abnormal population associated with a hematological malignancy. All subjects of any ethnicity, age and racial background will be included.

Exclusion Criteria:

* Specimens and/or spent samples that are visibly hemolyzed
* Specimens and/or spent samples that are visibly clotted
* Specimens and/or spent samples collected in K2EDTA anticoagulant older than 24 hours from time of collection
* Specimens and/or spent samples collected in Heparin or ACD anticoagulant older than 48 hours from time of collection
* Samples with insufficient volume to complete the protocol tests
The Effect of Breast Cancer and Breast Self-Examination

Background: Somali women face extremely high mortality and incidence rates for breast cancer (BC). One of the suggested techniques for screening for breast cancer early detection is breast self-examination, or BSE. Studies have revealed that Somalian women, however, lack sufficient understanding and practice about BC and BSE. In this study, female students at a university in Mogadishu, Somalia, had their knowledge, attitudes, health beliefs, and BSE practices evaluated with reference to the effects of health belief model-based health education addressing BC and BSE.

Methods: It was conducted as a randomized controlled study on 86 female university students in Mogadishu, Somalia, between September 2021 and June 2022. Randomization was used to assign participants to the intervention group (n = 43) and control group (n = 43). Data were gathered using two instruments: a self-administered questionnaire was the first tool used to gather information on individuals\&#39; sociodemographic and level of awareness about BC and BSE. The health belief model scale is the second instrument. A validated checklist and a modified structured questionnaire were used to gather data. Subsequently, the students in the experimental group took part in the three 90-minute training sessions that made up the program. The control group did not receive any intervention. Three months later, further student data were gathered. Data analysis was performed using IBM-SPSS software version 20, descriptive and inferential statistical tests (T-test, chi-square, repeated measures).


Eligibility Criteria:
Inclusion Criteria:

* Turkish and Somali instructors work together at the faculty and students are given education in Turkish. If students are successful in one year of Turkish preparation, they can then continue to the department of their choice. The population of the research consisted of 500 female students over the age of 18 studying at the Recep Tayyip Erdoğan Faculty of Health Sciences in Mogadishu, Somalia.

Exclusion Criteria:

-
Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery

The goal of this clinical trial is to test the use of a laxative before surgery in women having surgery to fix pelvic prolapse that do not have constipation.

The main question it aims to answer is: Does use of a laxative before surgery lessen the discomfort of bowel movements after surgery? Participants will be asked to complete questionnaires before and after surgery. Researchers will compare using the laxative before and after surgery versus only after surgery to see if there is less discomfort with bowel movements after surgery.

The purpose of this study is to evaluate if there is a difference in bother related to constipation between a pre-operative versus post-operative start of a bowel regimen for patients undergoing surgery for pelvic organ prolapse This will be a multi-institution, single-blind, randomized control trial utilizing questionnaires and chart review to evaluate effect of pre-operative bowel regimen on post-operative constipation.

1. Study team and surgeons will be blinded to group assignments, participants will not be.
2. Participants will be randomized after consent is obtained, and at least 1 week prior to planned surgery, via computer-generated blocks in a 1:1 ratio between study group (pre-operative and post-operative use) and control group (post-operative only use) of polyethylene glycol 3350 (PEG)

Eligibility Criteria:
Inclusion Criteria:

* Patients assigned female sex at birth undergoing an apical prolapse procedure including: sacrocolpopexy, sacrospinous ligament suspension, uterosacral ligament suspension, or colpocleisis. Planned urogynecologic procedure may include hysterectomy, adnexectomy, colporrhaphy, perineorrhaphy, or treatment of stress urinary incontinence.
* Planning to undergo primary procedure as above via minimally invasive route: vaginal or laparoscopic (including robotic-assisted). Including those that have an unplanned conversion intraoperatively of minimally invasive route to open laparotomy.

Exclusion Criteria:

* Diagnosis of irritable bowel syndrome, inflammatory bowel disease, slow transit constipation, obstructed defecation, or symptomatic constipation at time of study screening and recruitment. (Slow transit constipation and obstructed defecation defined as per American Gastroenterological Association 2013 constipation statement. Symptomatic constipation defined as any of the following: Bristol Stool Scale score of 1 or 2, PAC-SYM score greater than 1.0, self-reported 2 or less bowel movements per week.)
* Current use of pharmacologic laxative agent ≥1x/week (prescription or OTC) for the treatment of constipation symptoms
* Allergy or intolerance to polyethylene glycol 3350
* Planning to undergo surgery via laparotomy
* Scheduled for any concurrent non-urogynecologic procedure, ex abdominoplasty
* History of large bowel resection, surgical treatment of constipation, or anal sphincter surgery
* History of sacral neuromodulation
* Current or prior radiation therapy to the abdomen or pelvis
* Current or prior diagnosis of malignancy
* Unable to provide informed consent
Physical Rehabilitation Evaluation and Optimal Physical Therapy (PRE-OPT)

Phase 1: The investigators will conduct a prospective study to quantify the association between axillary web syndrome (AWS) and metastatic disease and chronic morbidities such as lymphedema, shoulder dysfunction, and pain comparing women (i) with AWS and (ii) without AWS in two cohorts of women. (n=200) Phase 2: This is a randomized controlled trial to 1) quantify the effects of (i) physical therapy compared to (ii) a control group in individuals with AWS following breast cancer surgery related to physical activity and physical impairments such as lymphedema, shoulder motion, function, and pain (n=44, 22 in each group). Funding to progress to Phase 2 of this trial has been obtained. It is anticipated 120 subjects participating in Phase 1 will be screened for eligibility for Phase 2 (separate consent and eligibility from Phase 1).


Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18
* Patients (female or male) with a tissue diagnosis of non-invasive or invasive breast cancer
* Planned surgical breast cancer treatment (lumpectomy or mastectomy) with a minimum removal of one axillary lymph node by sentinel node biopsy. Contralateral prophylactic mastectomy or bilateral mastectomy is allowed.
* Voluntary written consent signed before performance of any study-related procedure not part of normal medical care

Exclusion Criteria:

* Patients (patients unable to travel easily to the University of Minnesota Medical Center for post-surgery visits).
* Synchronous bilateral breast cancer
* Presence of a medical complication that would prevent the patient from being able to participate in the study, such as terminal cancer
* Previous history of upper extremity deep vein thrombosis
* Breast cancer surgery without lymph node removal
Pain, Physical Activity, Posture and Quality of Life in Post-COVID-19 Individuals With Idiopathic Scoliosis

It is not known to what extent the COVID-19 virus affects individuals with scoliosis during the prolonged COVID-19 pandemic. Therefore, in this study it was aimed to comparatively investigate pain severity, posture disorders that can be assessed by artificial intelligence, physical activity levels and quality of life in individuals with idiopathic scoliosis with and without COVID-19.

Various physical and psychological disorders observed in individuals with scoliosis have worsened during the pandemic period. However, it is still not fully known to what extent the COVID-19 virus affects individuals with scoliosis during the prolonged COVID-19 pandemic. For this reason, this study aimed to comparatively investigate pain severity, posture disorders that can be assessed by artificial intelligence, physical activity levels and quality of life in individuals with idiopathic scoliosis with and without COVID-19.

With the findings obtained from this way, it is expect that artificial intelligence technology will shed light on a new approach to the rehabilitation of individuals with idiopathic scoliosis who have suffered from COVID-19. In addition, if there is more pain, posture disorders, physical inactivity and quality of life disorders in individuals with scoliosis who have previously experienced COVID-19, it is also aimed to bring them to light. In this way, it will be possible to provide more specific direction to the rehabilitation of these individuals.

Eligibility Criteria:
Inclusion Criteria for individuals with idiopathic scoliosis who have experienced COVID-19:

* being 18 years of age or older
* Volunteering to participate in the study
* Having been diagnosed with idiopathic scoliosis
* Being able to walk independently
* Having been diagnosed with COVID-19 and having recovered and been discharged.

Inclusion criteria for individuals with idiopathic scoliosis who have not had COVID-19;

* being 18 years of age or older
* Volunteering to participate in the study
* Being diagnosed with idiopathic scoliosis

Exclusion criteria for individuals with idiopathic scoliosis who have had COVID-19;

* Having been diagnosed with COVID-19 in the last 15 days
* Being suspected of COVID-19
* Having mental problems that may affect cooperation
* Having an acute or chronic infection that may affect the evaluations to be made within the scope of the study.
* Participating in any professional sports activity
* Having any surgery to prevent walking, having a chronic disease, orthopedic/neurological/cardiopulmonary disease, physical or mental disability and/or cognitive impairment
* Using analgesics and other interactive drugs that will affect assessments
* Being pregnant

Exclusion criteria for individuals with idiopathic scoliosis who have not had COVID-19;

* Having had at least one COVID-19
* Being suspected of COVID-19
* Having any mental or physical disability
* Having any acute or chronic illness
* Having analgesic drug use that will affect the evaluations . Being pregnant
Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude

The purpose of the study is to investigate the effect of nasal continuous positive airway pressure in combination with acetazolamide as a treatment for sleep related breathing disturbances in patients with the obstructive sleep apnea syndrome living at low altitude during a sojourn at moderate altitude.


Eligibility Criteria:
Inclusion Criteria:

* Obstructive sleep apnea syndrome, successfully on CPAP therapy
* Residence at low altitude (\< 800 m)
* Obstructive apnea/hypopnea index \>20/h and a complaint of excessive daytime sleepiness before introduction of CPAP therapy
* \> 15 oxygen desaturations/h (\> 3% dips) during an ambulatory nocturnal pulse oximetry performed at the end of a 4-night period without CPAP

Exclusion Criteria:

* Sleep disorders other than OSA
* More than mild cardiovascular disease, unstable cardiovascular disease
* Any lung disease, pulmonary hypertension
* Chronic rhinitis
* Treatment with drugs that affect respiratory center drive (benzodiazepines or other sedatives or sleep inducing drugs, morphine or codeine derivates), stimulants (modafinil, methylphenidate, theophylline)
* Internal, neurologic or psychiatric disease that interfere with sleep quality
* Previous intolerance to moderate or low altitude (\< 2600 m)
* Exposure to altitudes \> 1500m for \> 1 day within the last 4 weeks before the study
Cost Effectiveness of OMT for Chronic Low Back Pain

The specific aim of this study is to conduct a prospective, multicenter cohort study over four months to compare the cost of standard of allopathic care (control group, N=90) versus standard of care plus osteopathic manipulative treatment (experimental group, N=90) in a cohort of 180 consecutive patients seeking treatment for chronic low back pain at three osteopathic clinics and three allopathic medical clinics (offering only standard care) located in three different regions of the United States.


Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with chronic low back pain (lasting more than 3 months) who are between 18 to 84 years old will be eligible for the study. Inclusion criteria will be specified by the following the 2017/2018 International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes associated with chronic low back pain:
* M54.16 Lumbar radiculopathy
* G57.01 Lesion of sciatic nerve, right lower limb
* G57.02 Lesion of sciatic nerve, left lower limb
* M48.061 Lumbar spinal stenosis, without neurogenic claudication
* M48.062 Lumbar spinal stenosis, with neurogenic claudication
* M47.816 Lumbar spondylosis
* M48.07 Lumbar spinal stenosis, lumbosacral
* M54.41 Lumbago with sciatica, right side
* M54.42 Lumbago with sciatica, left side

Exclusion Criteria:

* Patients with diabetic neuropathy, congenital lumbar and sacral abnormalities, lumbar fracture, multiple myeloma, metastatic bone disease, history of spinal and/or pain lasting less than three months will be excluded from the study.
A Study of tDCS for Unilateral Neglect in Stroke Patients

The primary objective of this study is to confirm and compare the effect of methods of transcranial direct current stimulation(tDCS) in the unilateral neglect of stroke patients

Total 105 patients were recruited and randomized to receive either real or sham-tDCS. Real experimental groups were divided into two types; Pre-tDCS group and Simultaneous tDCS group. Two groups are again divided into three groups; Dual stimulation group, Unilateral stimulation group and Sham control group, respectively.

In Pre-tDCS group, total a sessions of the tDCS stimulation was done for each three subgroups and visual inattention training was followed after that. In Simultaneous tDCS group, tDCS and visual inattention training was done simultaneously. For each subgroups, tDCS was attached at following locations; unilateral cathodal tDCS on unaffected PPC(postparietal cortex), P3 , dual cathodal tDCS on P3 and anodal tDCS on affected PPC, P4.

The patients were initially evaluated at baseline, immediately, 60min, 120min, 24 hrs after the training session.

Eligibility Criteria:
Inclusion Criteria

* Subjects who have diagnosed as primary stroke by physician's physical exam or radiologic diagnosis
* Subjects who have cortical or subcortical brain lesion
* Subjects ages older than 18years old
* Subjects who have 19 of K-MMSE score
* Subjects who has unilateral neglect with BIT-C less than 129
* Subjects who understand the purpose of the study and acquired the consent of the patient or caregiver
* Subjects who had no effect from brain stimulation or electrical stimulation therapy
* Subjects whose dominant side are confirm by Edinburgh Handedness Inventory

Exclusion criteria

* Subjects who have pre-existing and active major neurological disease
* Subjects who have pre-existing and active major psychiatric disease, such as major depression, schizophrenia, bipolar disease, or dementia
* Subjects who have brain lesion except cortex or subcortex area
* Subjects who have any metal component after brain surgery, low threshold to pain, history of seizure
* Subjects who is estimated as not appropriate for the study by the investigators
Study of Anxiety After a Session of Energy Resonance by Cutaneous Stimulation

Performing a breast macrobiopsy can be extremely delicate and anxiety-provoking. It can have an impact on the course of future examinations.

Patients' emotional feelings also have a definite impact on the nursing staff. The purpose of the MBRESC study is to evaluate Energy Resonance by Cutaneous Stimulation , a manual acupressure technique, in the management of anxiety prior to breast macrobiopsy.


Eligibility Criteria:
Inclusion Criteria:

* Patient has received full information on the organization and purpose of the research, and has signed an informed consent form.
* Patient over 18 years of age
* Patient undergoing a diagnostic breast macrobiopsy for suspected breast cancer
* Patient undergoing a macro breast biopsy for the first time
* Patient affiliated to or benefiting from a social security schem

Exclusion Criteria:

* Patient with a history of breast cancer or other pathologies requiring invasive procedures
* Patient with several lesions to be biopsied
* Patient with psychiatric pathology
* Patient under anxiolytic or psychotropic treatment initiated in the month before the breast macrobiopsy