cyrilzakka/clinical-trials huggingface dataset:
Effects of a Treadmill Gait Training Protocol in a Gamified Virtual Reality Environment With tDCS in Parkinson's Disease

The study aims to compare the effects of treadmill gait training in a gamified virtual reality environment with tDCS versus treadmill gait training in a gamified virtual reality environment versus treadmill training in people with Parkinson's Disease.

Treadmill gait training has been stablished as a solid gait rehabilitation option for people with Parkinson's Disease. However, gait training by itself fails to address the cognitive aspect needed for safe walking, which could be affected by situations in which concurrent tasks must be managed simultaneously to gait. It also lacks motivational aspects key to keep people with Parkinson's Disease adhered to treatment. Virtual reality and gamification are posed as useful tools to address both these issues, turning training into a more engaging activity and allowing complicated gait situations to be trained in a safe environment. Transcranial direct current stimulation (tDCS) could be combined with these mentioned treatment options, which could reinforce the learning of motor and cognitive skills during training.

The aim of this study is to evaluate the effects of the inclusion of a gamified virtual reality environment to a treadmill gait training program with tDCS in PD compared to the same training protocol with virtual reality and without it

Eligibility Criteria:
Inclusion Criteria:

* Idiopathic Parkinson's Disease
* Stage II - III in the Hoehn and Yahr Scale during ON state
* Ability to walk for 10 minutes independently without stop

Exclusion Criteria:

* Significant cognitive decline based on mini mental status examination (MMSE \<23)
* Severe auditory or visual deficits
* Other neurological/psychiatric conditions
* Any kind of cardiovascular complications that contraindicates physical activity
* Clinical history of any brain surgery or deep brain stimulation device
Feasibility and Impact of Remote Oximetry in Patients Hospitalized With Covid-19

The objective of MoxiCov is to monitor the oximetry of patients admitted to the Covid nursery to provide a more detailed assistance expecting to reduce the amount of hypoxia in these patients.


Eligibility Criteria:
Inclusion Criteria:

* Over 18 years old
* COVID 19 positive or suspected COVID19
Study of the Effects of Probiotics Upon Infectious Episodes in Subject Aged More Than 60, During Winter.

We put forward that probiotics have an effect on infectious episodes evolution in subjects aged 60 years or over. The main objective of this research is to observe the effect of consumption of the probiotic on the average number of days with infectious episodes.


Eligibility Criteria:
Inclusion Criteria:

* Subjects who accept not to alter their food habits

Exclusion Criteria:

* Food allergy
* Regular consumption of probiotics
* Diabetes
* Respiratory deficiency
* Cardiac deficiency
* Cancer or chronicle disease not stabilized
* Splenectomy, sickle-cell anemia
* Immuno depression or immunodeficiency acquired or congenital
* Immuno depressor or corticoid treatments
Successful Transitions and Reintegration Tools for Veterans (START-VETS)

This study will develop prison reentry materials for Veterans leaving prison.

This study will be conducted in three phases Phase 1is to collect qualitative data from Veterans who have recently been released from prison. The data will focus on their transition experience, stigma (both self and from others), and behaviors that interfered with success. Phase 2a will be to develop a transition program based around the needs identified in phase 1 Phase 2b will be to develop assessment tools to be used with the program Phase 3 will be to perform a two group randomized cross over design pilot study to assess the program

Eligibility Criteria:
Inclusion Criteria:

* Veteran with mental illness and/or substance use disorder released from prison within the past 36 months

Exclusion Criteria:

* psychosis or cognitive impairment precluding active participation
Vinegar Co-ingestion in Type 2 Diabetes

The main objective of this study is to assess the acute effect of co-ingested vinegar on postprandial plasma glucose levels in type 2 diabetes patients.

Plasma glucose and insulin concentrations are assessed over the 2 hr period following ingestion of carbohydrate-rich beverage with or without added vinegar.

Eligibility Criteria:
Inclusion Criteria:

* male type 2 diabetes
* overweight or obese
* 40-70 yrs

Exclusion Criteria:

* incident cardiovascular events during last year
* peptic ulcer, duodenal ulcer, oesophageal reflux
* antacids, H2 receptor blocker, proton pump inhibitors, NSAIDS, prokinetic agents
Photometric Stereo Endoscopy (PSE) as a Tool for Imaging the Rectum and Colon

The goal of this research is to assess photometric stereo endoscopy (PSE) as an endoscopic imaging technique. Specifically, topographical surface contrast reconstructed from the PSE data will be compared to conventional imaging contrast to assess if PSE provides enhanced contrast of abnormal tissue.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing a routine colonoscopy screening
* Patients must be over the age of 18
* Patients must be able to give informed consent

Exclusion Criteria:

* Patients with bleeding/hemostasis disorders
* Patients that are pregnant
* Patients taking any anti-coagulants that would preclude them from undergoing a standard of care colonoscopy, such as Coumadin and Plavix, at the time of the study
* Patients with known colitis or active bleeding will be excluded
Prevalence of Nocturnal Hypoventilation in Neuromuscular Diseases According to Different Definitions

Different definitions of nocturnal hypoventilation are used in the recent literature. The investigators aimed to compare the prevalence of nocturnal hypoventilation in a neuromuscular disease's population according to different definitions issued from the literature.

Different definitions of nocturnal hypoventilation are used in the recent literature. Basing on retrospective data review, we aimed to compare the prevalence of nocturnal hypoventilation in the cohort of neuromuscular disease's patients followed at our reference center, according to different definitions issued from the literature.

Eligibility Criteria:
Inclusion Criteria:

* Neuromuscular disease
* Age ≥18 years
* Non mechanically ventilated

Exclusion Criteria:

* Long-term oxygen therapy
Breathomics: May it Become an Affordable, New Tool for Early Diagnosis and Screening of Lung Cancer?

Breath analysis examining specific patterns of volatile organic compounds (VOCs) has been demonstrated to be able to discriminate lung cancer (LC) patients from healthy controls (HC). However, the existing technology uses complex, expensive, and low throughput analytical platforms to give an offline response, thus preventing its applicability for mass screening. The reliability of a new portable device to enable rapid, on-site LC diagnosis is tested.

The breath of patients with histologically proven NSCLC and healthy controls was sampled into Tedlar bags through a Nafion filter and a one-way mouthpiece. The breath samples in the bags were then analyzed by an automated micro portable gas chromatography device developed in-house, which consisted of a thermal desorption tube, thermal injector, separation column, and photoionization detector, as well as other accessories such as pumps, valves, and a helium cartridge. The chromatograms were analyzed by chemometrics and machine learning techniques.

Eligibility Criteria:
Inclusion Criteria:

* NSCLC histologically proven (for LC group) at any stage of disease
* non-cancer controls who had negative findings on preoperative chest X-rays/chest CT scan (for HC groups)

Exclusion Criteria:

* Patients who had any history of another type of cancer
* who had received neoadjuvant chemo/radiotherapy because of the possible unknown effects on cancer metabolism
* pediatric patients.
The Effect of Early Mobilization Training on Mobility, Pain and Comfort After Abdominal Surgery

The primary aim of this study is to examine the effects of in-bed rotation and early mobilization training given before abdominal surgery on mobility, pain and comfort of patients after surgery. The secondary aim of the study is to examine the effect of mobilization training given before abdominal surgery on the sleep of patients after surgery.

The primary aim of this clinical trial study is to examine the effects of early mobilization training given before abdominal surgery on mobility, pain and comfort of patients after surgery. The secondary aim of the study is to examine the effect of mobilization training given before abdominal surgery on the sleep of patients after surgery. Research Hypotheses are:

H11. There is a difference between the mobility scores of the patients who were given and not given pre-abdominal surgery training.

H12. There is a difference between the comfort scores of patients who were given and not given pre-abdominal surgery training.

H13. There is a difference between the sleep scores of the patients who were given and not given pre-abdominal surgery training.

First, the patient's mobility status in the preoperative period was evaluated with these scales. "Early Mobilization Training" will be given to the patients in the intervention group in the preoperative period. "Early Mobilization Training Material" to be prepared by the researcher will be used as training material. The training content will include information about the techniques and points to be considered about turning from one side to the other in the bed, sitting on the side of the bed, standing on the side of the bed and walking in the patient's room, and the time spent outside the bed on the day of surgery and the first and subsequent days after surgery.

After the patient's mobilization on the first day after the operation, the Patient Mobility Scale, the Postoperative Mobilization, the Visual Analogue Scale (VAS) questions questioning the pain and comfort during lying and sitting, and sleep status will be filled.

Eligibility Criteria:
Inclusion Criteria:

* over 18 years old
* those with abdominal surgery

Exclusion Criteria:

-
Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard

to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation


Eligibility Criteria:
Inclusion Criteria:

* a history of previous exposure to sulfur mustard
* worsening dyspnea during the last 10 days
* respiratory rate \>25/min
* arterial pH\<7.35
* PaCO2 of \>50 mmHg
* PaO2 of \<50 mmHg

Exclusion Criteria:

* recent pneumothorax (\<1 month)
* severe respiratory failure or hemodynamic instability with forthcoming intubation
* FIO2 of \<0.4
* impaired consciousness or absence of patient cooperation
* facial lesions precluding NIV
Effect of Timed-Restricted Eating on Metabolic Health

We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin resistance.

Obesity is an alarming global health issue, with increasing prevalence. Obesity leads to a vast array of disorders, including dyslipidemia, the accumulation of intrahepatic triglycerides (IHTG), multiorgan insulin resistance and type 2 diabetes mellitus. In addition, disruption of the circadian rhythm (circadian misalignment), which is associated with irregular eating schedules, is an important risk factor for the development of obesity, IHTG and type 2 diabetes mellitus. Time restricted eating (TRE) is a form of intermittent fasting, in which the daily eating period is restricted. The beneficial effect of this type of diet might relate to adequate synchronization of food intake and fasting to the internal rhythm of the circadian tissue clocks, improving metabolic handling of nutrients and metabolic flexibility.

Eligibility Criteria:
Inclusion Criteria:

* Ability to provide informed consent;
* BMI \> 30kg/m\^2;
* Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L;
* Stable weight for 3 months prior to study inclusion
* For women, 1 year after last menstrual cycle

Exclusion Criteria:

* Use of any medication, except for those related to treatment of metabolic syndrome;
* Any medical condition interfering with study outcomes or design;
* History of any psychiatric disorder, including eating disorders;
* Performing shift work
* Performing intensive sports (\>3 hours/week);
* Smoking;
* Drugs abuse or alcohol abuse (\>3 units/day);
* Contraindication for MRI;
* Known lactose/gluten intolerance;
* Known soy, egg, milk or peanut allergy;
* Childhood onset of obesity
Augmented Reality Treadmill Training in Patients With Parkinson's Disease

Gait disorder is a disabling symptom in Parkinson's disease (PD) affecting all patients during the course. Three methods of treadmill training (TT) will be compared to assess additional augmented reality (AR), or additional dual task (DT). AR TT, DT TT, and TT alone applied over 3 weeks at each day will be compared for their impact on falls, walking, freezing and attention for 3 months in a double blinded randomized controlled trial during regular neurorehabilitation.


Eligibility Criteria:
Inclusion Criteria:

* Informed Consent as documented by signature
* Parkinson´s disease without dementia and hallucination
* at least one fall within the past 3 months or postural instability
* Gait disorder
* Hoehn and Yahr stages II-IV
* able to perform the treadmill therapy during a study

Exclusion Criteria:

* Contraindications to treadmill therapy (e.g. hip fracture)
* Dementia as defined by an Montreal cognitive assessment (MOCA) \< 20
Use of Public Access Defibrillators by Untrained Bystanders

Survival from out-of-hospital cardiac arrest is time critical and diminishes rapidly without appropriate intervention. Bystander CPR at least doubles the chances of survival and the additional use of a public access defibrillator (PAD) can again double overall survival rates. PADs are designed to be easy and simple to use, but whether untrained bystanders can use them safely and effectively is unknown. This study will aim to assess the ability of untrained bystanders to deploy a PAD in a simulated cardiac arrest.

Survival from out-of-hospital cardiac arrest is time critical and diminishes rapidly without appropriate intervention. Overall survival is no more than 10% in the UK.

Bystander CPR at least doubles the chances of survival and the additional use of a public access defibrillator (PAD) can again double overall survival rates. Because PADs can make such a dramatic increase in chances of survival, public health programmes have encouraged the deployment of PADs in areas of high public density in order to deliver early defibrillation prior to ambulance arrival. Where this can be achieved, survival rates as high as 50% have been reported.

PADs are designed to be easy and simple to use, and in addition to graphical instructions on the device, give verbal instructions to a rescuer in order to ensure the PAD is used correctly. Most bystanders who are first on scene at a cardiac arrest have no first aid training and it is not always possible to wait for someone with first aid training to be available to use a PAD. Several guidelines, such as those from the Resuscitation Council (UK), state that untrained bystanders can use a PAD, but there has been little evaluation to understand whether this can safely and effectively be achieved without specific PAD training.

This study will aim to assess the ability of untrained bystanders to safely and effectively deploy a PAD in a simulated cardiac arrest, specifically aiming to identify differences between the features of different devices that improve their ease of use in order to understand what design features are required for optimal design.

Eligibility Criteria:
Inclusion Criteria:

* Members of the public who have never received any first aid (CPR) training

Exclusion Criteria:

* Those less than 16 yrs age
* Those with any physical disability precluding the use of a PAD
Adenosine Testing to DEtermine the Need for Pacing Therapy

The purpose of this study is to determine whether or not the intravenous adenosine test readily identifies patients with unexplained syncope who would benefit from permanent pacemaker implantation.

The investigation of syncope (transient loss of consciousness with loss of postural tone, collapse and spontaneous recovery) varies widely, is often lengthy and frequently expensive. The intravenous adenosine test has been used in the investigation of syncope and is cheap, safe and free of serious side effects. However, it is unclear what diagnosis the test unearths. There is some evidence that the test readily identifies bradycardia pacing indications.

In this study we plan to perform the adenosine test and implant a pacemaker should the test be positive. In half of the patients we will turn the pacemaker "on" and in the other half the pacemaker "off". The groups will swap over after six months. During this time we will assess the number of syncopal episodes. Also, in those who have a negative adenosine test we will implant a loop recorder to try to discover the cause of syncope.

Eligibility Criteria:
Inclusion Criteria:

* Episode of syncope
* Patient has provided written informed consent for participation in the study prior to any study specific procedures
* Male or female
* Age \> 40 years
* No cause of syncope clearly identified on clinical examination, lying and standing blood pressure measurements and standard 12 lead ECG.

Exclusion Criteria:

* Asthma or chronic obstructive pulmonary disease
* Severe coronary disease (myocardial infarction within 3 months, known coronary stenosis \>70%, NYHA heart failure or angina symptoms Class III or IV)
* Known severe cerebrovascular disease or known significant internal carotid artery stenosis (\>70%)
* Prolonged corrected QT interval
* Unablated accessory pathway
* Pregnancy or lactation
* Use of dipyridamole or any rate-limiting medication that cannot be safely discontinued
* Hypertrophic cardiomyopathy
* Cardiac transplantation
* Concurrent participation in another investigational study or trial
* Inability to give informed consent; carer/proxy assent will be allowed in this study
* Cause of syncope established from initial clinical history and examination, lying and standing blood pressure and ECG
Vitamin C to Reduce Morning Cardiovascular Risk

This study will test the efficacy of Vitamin C to counteract morning cardiovascular (CV) risk markers in a randomized, double blind, placebo controlled crossover pilot study. The participants will also perform morning typical behaviors such as arousal from sleep, change in posture (getting out of bed) and mild intensity physical activity; identical to the stressors encountered in everyday life. Primary dependent variables are markers of cardiovascular risk including vascular endothelial function and oxidative stress.

The investigators plan to test the efficacy of Vitamin C to counteract morning cardiovascular (CV) risk markers in a randomized, double blind, placebo controlled crossover pilot study. The participants will also perform morning typical behaviors such as arousal from sleep, change in posture (getting out of bed) and mild intensity physical activity; identical to the stressors encountered in everyday life. This pilot study is in healthy middle aged adults without a history of CV disease.

Participants will spend two nights in an inpatient hospital suite at Hatfield Research Center. Upon awakening in the morning, they will either ingest Vitamin C or placebo in a randomized order. This will be followed by moderate intensity exercise, recovery, and discharge.

Eligibility Criteria:
Inclusion Criteria:

* Healthy participants
* Normal weight or overweight but not obese (18.5\<BMI\<33 kg/m2)

Exclusion Criteria:

* History of smoking/tobacco use
* Current prescription/non-prescription medications or drugs of abuse
* Acute, chronic, or debilitating medical conditions
* History of working irregular day and night hours, regular night work, or rotating shift work for the six months prior to the study.
Reduction of Cesareans by Nitric Oxide (NO) Donors in Post Term Pregnancies

The purpose of this trial is to determine whether cervical ripening with isosorbide mononitrate reduce caesarean section in women with post term pregnancies.

The purpose of this trial is to determine whether cervical ripening with 40 mg of isosorbide mononitrate given intravaginally at 41+0, 41+2 and 41+4 weeks reduce cesarean section in nullipara with post term pregnancies. Treatments will be administered by midwifes in the maternity wards, women will be allowed to go back home in case of Bishop score\<6. Otherwise labor will be induced with oxytocin. If undelivered at 41+5, women with Bishop score\<6 will be induced with prostaglandins according to local protocols.

Eligibility Criteria:
Inclusion criteria :

* Age \> or = 18 years old
* TAS \> or = 95 mmHg
* Singleton
* Nulliparity
* Term \> or = 41 weeks + 0 day
* Bishop score \< or = 5
* Vertex presentation
* Intact membranes
* No contra-indications of the study treatment
* No maternal or fetal diseases which could indicate immediate labor induction
* Written informed consent

Exclusion criteria :

* Multiple pregnancy
* Multiparity
* Term \< 41 weeks
* Bishop score \> 5
* Breech presentation
* Rupture of the membranes
* Previous cesarean
* Indication to immediate labor induction
* Contraindications to isosorbide mononitrate
* No co-administration of antihypertensive drugs
* No social security