cyrilzakka/clinical-trials huggingface dataset:
Prescription of Benzodiazepines by General Practitioners: Characteristics of Prescribing Trend and Implementation of an Online Educational Program

Portugal has the highest benzodiazepine utilization compared to other European countries. The high utilization of benzodiazepines has been a concern due to reported side effects of long-term use and dependence. Also, these data demonstrate that doctors are possibly choosing an inadequate treatment to manage anxious and depressive syndromes.

This research aims to develop and implement in primary health care units an online educational program, following a cluster randomized study design; to study the impact of this educational program for changing general practitioner's benzodiazepine prescription pattern; to analyze of barriers and facilitators to the implementation of the e-PrimaPrescribe program.

BZD excessive prescription has long been considered a serious mental health concern in many countries. A large number of interventions using different methodologies have been implemented to change BZD prescription pattern at primary health care settings, with limited positive results.

The investigators propose the implementation of an effectiveness-implementation hybrid type 1 intervention. In the study it was developed an online platform, named ePrimaPrescribe, which was delivered using a Digital Behavior Change Intervention(DBCI).

The investigators included all primary health care units from one region in Portugal which were randomly allocated to receive a Digital Behavior Change Intervention (DBCI) in the format of an online platform to reduce BZD prescription (ePrimaPrescribe) or an online platform concerning communication techniques (control).

The investigators primarily aimed to evaluate the effectiveness of the Digital Behavior Change Intervention (DBCI) using as outcome measure the frequency of BZD prescriptions issued per month. Secondarily the investigators aimed to analyze the effect of ePrimaprescribe on antidepressant prescriptions, to study the effect of ePrimaprescribe on diagnosis definition associated with BZD and antidepressant prescription; to perform a cost analysis considering the monthly National Health Service spending with BZD co-payment. The investigators finally aim to analyze the implementation process using quantitative and qualitative methods.

Eligibility Criteria:
Inclusion Criteria:

* Primary care units using the Portuguese online prescription tool (created by the Portuguese Shared Services of the Ministry of Health and Finance - SPMS)

Exclusion Criteria:

* Primary care units involved in another trial concerning mental health topics directly related with the subject of this thesis
Home-based Training in Obese Individuals

Generally, the enhancement of physical fitness depends on the optimal modulation of different physiological, technical or psychological stimuli and within the factors the would contribute to a decrease performance level, obesity is one of them. In this context, ample evidence shows that obesity is associated with an augmented cardio-metabolic risk, lowered postural control, functional performance and strength-related variables. International guidelines suggests to counteract obesity to respect a minimum dosage of 150 min a week of physical activity at moderate intensity performed with resistance training exercises with a frequency of 2-3 days/week. However, in the aforementioned guidelines there is a little consideration for what concern the quality of motor execution (i.e., "how" an individual performs each movement pattern). In addition, the available literature demonstrates the effectiveness of a "movement-quality" training intervention on fitness parameters and postural control, compared to a mere conventional exercise, in normal-weight individuals . In account to this, the purpose is to evaluate whether a quality of movement protocol would be more effective than a traditional strength training exercise in improving postural control and fitness parameters in subjects with obesity.


Eligibility Criteria:
Inclusion Criteria:

* physical activity frequency at least 1 days per week
* BMI index more than 30 kg/m2
* informed consent signature

Exclusion Criteria:

* aged more than 70 years
* patients with knee pain (Visual Analogue Scale \> 7 a.u.)
* history of hip or knee replacement
* severe hip or knee osteoarthrosis
* cardiac or neurological condition contraindicating physical activity
Semantic Recognition Task (SRT) in Alzheimer Disease

The goal of this study is to observe the outcomes of a semantic recognition task in Alzheimer Disease and discuss what this might add to clinical practice.

In classical memory testing procedures, the outcomes of recognition task is related to hippocampal memory deficits knowing that the recognition task is not purely temporal lobe activity. The aim of this study is to propose a recognition task more specific to temporal lobe activity.

Eligibility Criteria:
Inclusion Criteria:

* to have biomarker analysis for Alzheimer disease (positive or negative).

Exclusion Criteria:

* illiteracy
Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) in Dental Phobia

The purpose of this study is to find out whether Eye Movement Desensitization and Reprocessing (EMDR) is effective in the treatment of patients with dental phobia.

Dental phobia represents a clinical condition that affects 5-15% of the community and is characterized by severe anxiety of dental treatment which leads to avoidance of treatment and, as a consequence, severe dental as well as psychosocial problems.

Eye Movement Desensitization and Reprocessing (EMDR) has been developed for the treatment of patients with post traumatic stress disorder (PTSD). Its efficacy in PTSD patients has often been demonstrated in randomized controlled trials.

Recently it has been demonstrated that dental phobia is often induced by traumatic events during dental treatment and goes along with symptoms of PTSD in numerous patients.

A pilot study (de Jongh et al. 2002) gave hints on the efficacy of EMDR in four dental phobia patients with a history of traumatization during dental treatment.

This randomized wait-list control study aims to evaluate the efficacy of EMDR in a larger sample of dental phobia patients.

Eligibility Criteria:
Inclusion Criteria:

* dental phobia according to the World Health Organization´s International Classification of Diseases, ICD-10 (F40.2)

Exclusion Criteria:

* schizophrenic disorder
* severe depression
* severe dissociative disorder
* organic brain disease
* anorexia nervosa (body mass index, BMI \< 17)
* suicidality
* severe cardio-vascular disease
* ophthalmic disease
* pregnancy and lactation
* psychopharmacological treatment
* substance abuse
Baby Swim As an Intervention for Depressive Symptoms and Lacking Attachment During the Postpartum Period

Mental health issues are very common during and after pregnancy, and studies from around the world indicate that 10-15% of all pregnant and postpartum women experience depression. Risk factors for developing depression include a history of depression, low levels of social support, and stressful life events. The symptoms are the same as for depression during other periods of life, but often include feelings of inadequacy regarding motherhood, along with associated feelings of shame or guilt. Obsessive thoughts directed toward the baby may also be part of the symptomatology. Such thoughts are typically experienced as frightening by the mother but, in the vast majority of cases, do not pose any risk to the child. Maternal depression can also affect a mother's ability to bond with her baby, and difficulties in forming an attachment can, in turn, increase and perpetuate depressive symptoms. In the long term, insecure attachment between mother and child can lead to behavioral problems in the child, such as aggression and avoidance, anxiety and depression in adolescence, negative effects on cognitive development, and trust issues in close relationships.

Baby swimming is a structured form of interaction that takes place in 34-degree Celsius water in a calm environment, aiming to teach the baby vital skills while stimulating social, intellectual, and motor development. At least one parent actively participates and is encouraged to perform various exercises. These activities strengthen the bond between the baby and the parent and contribute to making time in the water a safe and enjoyable experience. Previous studies have shown that baby swimming can improve attachment between parent and child.

In the present project, the aim is to investigate whether baby swimming can be used as an intervention for depressive symptoms in new mothers and whether this intervention can reduce depressive symptoms while also strengthening the bond between mother and child.


Eligibility Criteria:
Inclusion Criteria:

Women who have

* given birth at full term
* are 18 years or older
* have a baby aged 3-7 months at the time of inclusion
* exhibit depressive symptoms according to the EPDS scale.

Exclusion Criteria:

* Multiple pregnancy (twins, triplets)
* Known psychotic disorder or bipolar disorder
* Inability to communicate adequately in Swedish or English, or inability to read and complete digital questionnaires in Swedish or English.
Junior Emergency Physician Learning Curve to Perform Transcranial Doppler on Brain-damage Patients

Transcranial Doppler is a noninvasive tool. Using velocity measurements and pulsatility index it allows the evaluation of cerebral haemodynamics. In patients presenting brain injury cerebral perfusion may be impaired. Indirect cerebral blood flow can be monitored and risk of neurological worsening can be detected using transcranial Doppler. Education and performance of emergency physicians must be evaluated on brain-injured patients because this tool is operator dependent. The main objective of this study is to estimate the average number of exams required to learn transcranial Doppler within junior emergency physicians with the achievement of their learning curve. We will perform a prospective, monocentric, observational study within the neurosurgical resuscitation department of Grenoble Alpes University Hospital.

The transcranial dopplers will be carry out on 75 brain-damaged patients by 13 emergency residents physicians after a theoretical and practical training. They will be evaluated by 8 experts. The primary endpoint will be the mean number of transcranial dopplers required to have an excellent concordance between resident and expert. The concordance between the Doppler findings of the resident and the expert would exceed 0.8 before 30 examinations. The learning curve assessed on the duration necessary to acquire good quality data should decrease rapidly with the repetition of the examinations. Validating the transcranial Doppler learning curve for junior emergency physician would allow them to perform this exam safely and efficiently. Transcranial Doppler may be easy and fast to learn but the persistence of its competency over time should be evaluated.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients : ≥ 18 year and older
* Hospitalized in the neurosurgical resuscitation or intensive care unit
* Brain - damaged patients

Exclusion Criteria:

* Any craniotemporal lesion impeding satisfactory TDC examination : no transtemporal doppler window, patient with craniectomy.
* Patient with meningo-encephalitis
* Patient with cerebral vasculitis
* Patient without health insurance coverage
* Patient subject to a legal protection measure
* Pregnant woman , parturient or nursing
Artificial Intelligence-assisted Glaucoma Screening (AIAGS)

This study will develop an artificial intelligence (AI) program for the screening of glaucoma.

We have realized that the glaucomatous optic neuropathy is irreversible. But if early detection and early intervention can be performed to control the development of the disease, it can greatly reduce the blindness rate of glaucoma, improve the life quality and physiological and mental health of patients, and alleviate the social burden. Therefore, screening and early diagnosis of glaucoma is the focus of glaucoma prevention.

China has a population of 1.3 billion, which greatly increase the difficulty of disease screening. In recent years, the intersection of artificial intelligence (AI) technology and modern medicine has made efficient and rapid disease screening possible.

Eligibility Criteria:
Inclusion Criteria:

* able to complete fundus images

Exclusion Criteria:

* unable to complete fundus images
Reproductive Outcome of EM Treated by GnRH-a Associated With Laparoscopy

This study is a multicenter, randomized-control-trial. This study select 1184 Infertile patients associated with endometriosis diagnosed by laparoscopy surgery. Patients are going to be divided into two groups according to 1:1 ratio randomly assigned to receive GnRH-a. Cumulative pregnancy rate, end of treatment to natural pregnancy time, accept the assisted reproductive treatment rate, miscarriage rate, live birth rate will be recorded.


Eligibility Criteria:
Inclusion Criteria:

* Infertile patients
* Endometriosis I-II phase：according to Revised American Society for Reproductive Medicine classification of endometriosis: 1996
* BMI:19-28 kg/㎡
* Ovarian reserve function is normal（M2-5：bilateral antral follicles≥6 FSH：5-12U/ml）

Exclusion Criteria:

* Male factor causes infertility
* hydrosalpinx or salpingemphraxis
* Uterine malformation
* Uterine cavity lesion
* Contra-indications for GnRH-a
* not willing to participate
An Observational Prospective Study to Understand the Usage Pattern of Ticagrelor With ACS (Acute Coronary Syndrome)

The TREASURE observational study is designed to address the need to understand the usage pattern of Ticagrelor in real life scenario in large number of ACS (Acute Coronary Syndrome) patients in India. The aim of this national study is to understand the usage pattern (including the duration of treatment) of Ticagrelor in various ACS patient population undergoing PCI (Percutaneous Coronary Intervention), CABG (Coronary Artery Bypass Graft) or medical management in a real-life setting in India.

This study is a multi-centre, observational, prospective study to be conducted at 60 hospitals across IndiaThe study will be initiated after obtaining written approval of Independent Ethics Committee (IEC) and written Informed consent of the patient.

Patients who had been hospitalized for ACS and are on ticagrelor on discharge or on Ticagrelor therapy for ≤ 1month will be enrolled in the study and followed up for a period of 12 months. During the follow-up period of up to 12 months (according to the label), assessment visits will follow the routine clinical practice. No visits or measurements will be made mandatory by the protocol

Eligibility Criteria:
Inclusion Criteria:

1. Written informed consent has been provided.
2. Aged 18 years or older.
3. Male/female with ACS on Ticagrelor on discharge or ≤ 1month.
4. Patient underwent PCI, CABG or MM (Medical Management) for ACS.
5. Diagnosis of STEMI, NSTEMI or UA

Exclusion Criteria:

1. Patients with medical history of intracranial hemorrhage
2. All those patients who are not fit to receive Ticagrelor as per the latest prescribing information
Clinical and Radiographic Outcomes of Implant-supported Prostheses With Cantilever Extensions After 10 Years of Function

A retrospective examination was performed on patients who had received treatment with dental implants supporting a prosthesis with a cantilever extension for at least 10 years of function.

The successful use of osseointegrated dental implants in replacing missing teeth has been adequately documented, with multiple studies reporting long-term success exceeding 10 years of function. However, there is still insufficient evidence in cases where availability of adequate bone precludes ideal placement of implants. Examples of cases like these include the posterior maxilla when pneumatization of the maxillary sinus does not allow for placement of implants, or areas of thin bone that would require extensive guided bone regeneration (GBR) techniques and increase patient morbidity. In such cases the use of fixed dental prostheses (FDPC's) with cantilever extension has been suggested in lieu of sinus lift techniques or GBR procedures. However, few studies have actually addressed the long-term success of such FDPC's, both from a surgical and a prosthetic standpoint, especially in posterior areas of the mandible and maxilla where loading forces are expected to be higher.

Two studies addressed this issue in the early 2000's with successful outcomes reported for an observation period of 5 years. Others reported similar outcomes after a mean observation period of 5.6 years. The 5th Consensus Conference of the European Association of Osseointegration (EAO) suggested that such treatment can be recommended to patients, albeit with little available evidence and limited follow-up of cases. Recent studies have delved further into this issue, offering longer follow-up data of more than 10 years of function. They included both 2 unit FDP's anchored on one implant and 3 unit FDP's anchored on two implants with cantilever extensions. They concluded that this treatment modality is a reliable option with long-term stability and few complications, mainly prosthetic.

The aim of this retrospective study is to offer further data on the long-term success and complications when at least two dental implants are used to support a FDPC in the posterior areas of both jaws, after at least 10 years of function.

Eligibility Criteria:
The inclusion criteria were as follows:

* Age 18 years and over
* Systemic health or controlled medical conditions
* Periodontal health, either no periodontal disease, or previously treated periodontal disease and under a supportive periodontal maintenance (SPT) program
* Smokers were included but encouraged to enter a smoking cessation program
* Patients with bruxism or parafunctional habits were included.

The exclusion criteria were as follows:

* Uncontrolled medical conditions
* Active uncontrolled periodontal disease
* Inability to present for the reevaluation appointment
* Immediate implant placement
* Cantilever units that were part of full-arch restorations
* Cantilever units that were connected to a single implant
* Non-existent opposing dentition
A Phase 2, Multicenter, Open-label Study to Assess the Immunogenicity of an Investigational Hib Vaccine (NU300)in Toddlers

Evaluate the safety and tolerability of a single booster dose of NU300, co-administered with Prevnar 13® over a 28 day period following the injection compared to a single booster of ACTHIB co-administered with Prevnar 13® over a 28 day period following the injection.

Evaluate the immunogenicity, as determined by anti-PRP polysaccharide response, of a single booster dose of NU300 co-administered with Prevnar 13® compared to a single booster dose of ActHIB® co-administered with Prevnar 13®.

Evaluate the individual IgG antibody quantitative response to the 13 antigens in Prevnar 13® following NU300 co-administration with Prevnar 13® compared to the IgG antibody response to the pneumococcal polysaccharides following ActHIB® co-administration with Prevnar 13® 28 days following injection.


Eligibility Criteria:
Inclusion Criteria:

1. Written informed consent obtained from the parent or guardian of the subject
2. Male or female subjects 12-15 months of age at the time of booster vaccination, who had previously received complete primary vaccination series with a licensed Hib product and Prevnar 13® in accordance with the FDA approved labels.
3. Subjects for whom the investigator believes that the parent/guardian can and will comply with the requirements of the protocol
4. Subjects free of obvious health problems as established by medical history and clinical examination before entering the study

Exclusion Criteria:

1. Previous booster vaccination against Hib and/or Prevnar 13®
2. Any confirmed or suspected Haemophilus influenzae or pneumococcal illness.
3. Administration of a vaccine not foreseen by the study protocol during the period starting from 30 days before and ending 28 days after administration of study vaccines (before the blood draw at Visit 2).
4. Chronic administration of immunosuppressants or other immune-modifying drugs within 30 days prior to dosing in the study.
5. Any confirmed or suspected immunosuppressive or immunodeficient condition based on medical history and/or clinical examination.
6. Early pre-term birth (delivery before 32 weeks).
7. Major congenital defects or serious chronic diseases, or serious conditions including history of seizures, apnea, etc.
8. Concurrent participation in another clinical study at any time during the study period or within the previous 6 months in which the subject has been or will be exposed to an investigational or non-investigational product (pharmaceutical product, formula, or device)
9. Presence of a moderate or severe illness with or without fever at the time of vaccination (fever is defined as a temperature of ≥ 38.0C \[100.4F\]).
10. Known history of thrombocytopenia or any coagulation disorder.
11. Known hypersensitivity to any of the components of the vaccines.
12. Known hypersensitivity to latex.
13. The subject is unable to provide an adequate blood draw for immunogenicity assays, and safety panels at Visit 1
Study of TQ-F3083 Capsules in Subjects With Type 2 Diabetes Mellitus

TQ-F3083 capsule is a new type inhibitor of DPP-IV, which is currently a very effective target for the treatment of type 2 diabetes mellitus at clinical. In addition, it can promote insulin secretion with low potential toxicity, and half-life is shorter than Linagliptin.


Eligibility Criteria:
Inclusion Criteria:

1.Understood and signed an informed consent form; 2.18 and 70 years old; 3.Body mass index (BMI) of 19 to 37.5 kg/m2; 4.Type 2 diabetes mellitus confirmed at least 6 weeks before screen by WHO (1999) diabetes mellitus diagnostic criteria; 5.Has inadequate glycemic control on diet/exercise therapy and irregular use hypoglycemic agents before screening, HbA1c ≥7.0% and ≤10.0% ; Has regular hypoglycemic agents with stable dose within 6 weeks before screening, HbA1c ≥7.0% and ≤9 %; 6.PFG ≤ 13.3 mmol / L; 7. Adequate laboratory inspection standards.

Exclusion Criteria:

1. Has any contraindications, allergies or hypersensitivity for taking research medication ;
2. Has used at lest two oral medications to treat diabetes mellitus 6 weeks before screening;
3. Has other endocrine-related history or evidence before screening;
4. Has history of organ transplantation;
5. Has mental or neurological diseases;
6. Has received systemic corticosteroids within 2 weeks;
7. Has received GLP-1 analogues, DPP-4 inhibitors or anti-obesity drugs 3 months ;
8. Has alcohol abuse history within 6 months before screening;
9. Has participated in any clinical trial within 3 months;
10. Has received blood transfusions, or blood donation ≥ 400 mL , or got severe blood loss ≥ 400 mL within 8 weeks;
11. Pregnant or lactating woman.