cyrilzakka/clinical-trials huggingface dataset:
Attitudes and Stigma Towards Suicidal Behavior in Intensive Care and Emergency Service Nurses

The aim of this study is to determine the attitudes and stigmatization levels of nurses working in the intensive care and emergency departments towards suicidal behavior.

Suicide is an important and priority public health problem. In the last 45 years, the suicide rate in the world has increased by 60%. About 800,000 people die each year due to suicide. Suicide can be prevented with timely, evidence-based, and often low-cost interventions. The first places that individuals who attempt suicide apply are often the emergency departments of hospitals. These individuals are then referred to intensive care units for close follow-up of physical findings and treatment according to the results of the suicide attempt. Nurses working in the emergency room and general intensive care unit should consider the need for psychosocial support while taking precautions against the physiological consequences of suicide in order for the individual to survive. In the care of an individual who has attempted suicide, the nurse has responsibilities such as providing education to the patient, creating a safety plan, counseling for the restriction of deadly vehicles, quick referral to the necessary places, and providing contact with post-discharge care. It is a priority in the care of the individual that the nurse reduces the sense of hopelessness of the individual who comes with a suicide attempt, re-establishes the sense of commitment to other people, increases compliance with the treatment, motivates for change, and establishes therapeutic communication. In this regard, the knowledge level of healthcare professionals and nurses who provide primary care to patients, and their attitudes towards suicide are important. When the literature is examined, studies on the attitudes of health professionals working in the emergency room toward suicide attempts have been observed, but no research has been found that determines both the attitudes and stigmatization levels of intensive care and emergency room nurses toward suicidal behavior. For this reason, this study was planned to determine the attitudes and stigmatization levels of nurses working in the general intensive care and emergency departments towards suicidal behavior.

Eligibility Criteria:
Inclusion Criteria:

* Having no barriers in oral and written communication in Turkish
* Volunteering to participate in research
* Working in the general intensive care or emergency department of the hospital

Exclusion Criteria:

* Giving incomplete or incorrect information to forms
PDE-4 Inhibitor Roflumilast and GLP-1 Agonist Liraglutide in Polycystic Ovary Syndrome

The purpose of this study was to determine whether monotherapy treatment with phosphodiesterase-4 (PDE-4) inhibitor roflumilast is more effective than treatment with glucagon-like protein 1 (GLP-1) liraglutide or treatment with metformin as monotherapy in the treatment of obese women with polycystic ovary syndrome (PCOS) regarding weight reduction who have not been treated before. The investigators anticipated greater changes in body weight in patients on roflumilast treatment than in liraglutide or metformin.


Eligibility Criteria:
Inclusion Criteria:

* 18 years old to menopause
* polycystic ovary syndrome (NICHD criteria)
* BMI of 30 kg/m² or higher

Exclusion Criteria:

* depression
* type 1 or type 2 diabetes mellitus
* history of carcinoma
* history of pancreatitis
* Cushing's syndrome or congenital (non-classic) adrenal hyperplasia
* significant cardiovascular, kidney or hepatic disease
* the use of medications other than metformin known or suspected to affect reproductive or metabolic functions
* the use of statins, within 90 days prior to study entry
Survey Study About Endoscopy During COVID-19 Pandemic for IBD Doctors

Performance of diagnostic or therapeutic endoscopic procedures in inflammatory bowel disease (IBD) patients can be challenging during a viral pandemic; the main concerns being the safety and protection of patients and health care providers (HCP). The aim of this study is to identify endoscopic practice patterns and outcomes of IBD and coronavirus disease 19 (COVID-19) with a worldwide survey of HCP.

The 20-item survey questionnaire was sent to physician members of the American Society for Gastrointestinal Endoscopy Special Interest Group in Interventional IBD, Chinese IBD Society Endoscopy Interest Group, and the China Crohn's and Colitis Foundation. The data of the survey was collected and analyzed.

Eligibility Criteria:
Inclusion Criteria:

1. Doctors who are involved in the endoscopic treatment of IBD patients;
2. The endoscopist reads and signs an informed consent online. -

Exclusion Criteria:

1. Doctors who are not involved in the endoscopic treatment of IBD patients
2. Doctors who need the help of an agent, a witness, or someone else who can not complete the questionnaire independently.
3. Other conditions that the researchers considered unsuitable for inclusion or influenced the participants'ability to complete the study.-
Endothelin Antagonism in ANCA Vasculitis

Patients with vasculitis commonly develop cardiovascular disease. The reasons for this are not clear and is not adequately treated with current drugs. It is thus understand the reasons why patients with vasculitis develop cardiovascular disease in order to develop new drugs to reduced this risk.

Endothelin is a chemical produced by blood vessels that contributes to the development of hypertension and cardiovascular disease Higher than normal levels of endothelin are seen in patients with vasculitis but how this contributes to cardiovascular disease in patients with vasculitis is not clear. By using drugs that block the effects of endothelin ('endothelin receptor antagonists') the investigators can hopefully reduce the risk of cardiovascular disease in patients with vasculitis. The purpose of the study is to ascertain if endothelin receptor antagonists improve blood vessel function in patients with vasculitis.

Vasculitis patients and healthy controls matched for age, sex will be enrolled into the study. Patients will attend for 4 study days \>1 week apart, whereas controls will attend for single day. Circulating Mφ and other immune cells will be confirmed using FACS prior each study.

Study 1 Both patients and control will attend for visit 1: assessment of vascular function using forearm plethysmography as part of case control study.

Vasculitis patients will then attend for visits 2, 3 \& 4 as part of randomised three way crossover study (randomised \& infusions given in a double-blind method): comparison of the effects of selective ETA receptor antagonism (BQ123; 1000nmol/min for 15min iv), mixed ETA/B antagonism (BQ123/788; 1000 nmol/min \& 300 nmol/min for 15 min), and placebo on systemic haemodynamics.

Eligibility Criteria:
Inclusion Criteria:

* Male or female
* Age 18 years and over
* Body mass index ≤35
* Normal serum albumin

Exclusion Criteria:

* Subject with diabetes or current smoking or chronic kidney disease (eGFR \<60ml/min)
* Subject with pre-existing cardiovascular disease
* Subject is below the age of legal consent, or is mentally or legally incapacitated
* History of multiple and/or severe allergic reactions to drugs (including study drugs)
* The subject has donated blood (450 ml) within the last 4 weeks
* Past or present drug or alcohol abuse including intravenous drug abuse at any time
* Participation in another clinical trial within 1 month
* Considered to be at high risk of HIV or hepatitis B
* Women of child-bearing potential (only women who are post-menopausal or surgically-sterilised will be included in the study)
Dual-task Performance in Young-onset PD

This study aimed to investigate the effects of Game based dual-task training with treadmill on executive function and dual-task performance in individuals with early-onset PD and discuss the correlation between the change values of executive function and dual-task performance after training. Besides, investigate cortical activation after training.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed as PD and Hoehn and Yahr stage between 1\~3
* Age between 20 to 80
* Able to walk 10 m independently without an assistive device
* A score of greater than or equal to 24 on the mini-mental state examination (MMSE)
* In stable medical condition allowing participation in the testing protocol and intervention

Exclusion Criteria:

* Any comorbidity or disability other than PD that would preclude gait training
* Any uncontrolled health condition for which exercise was contraindicated
* Any neurological or orthopedic disease that might interfere with the study
* Server freezing of gait, FOG questionnaire \> 15
Radiostereometric Analysis of Acetabular Wear and Periprosthetic Bone Mineral Density Changes in Hemiarthroplasties

Substudy and continuation of HEMI-SAB-UUS (NCT00491673)

Study on radiostereometric measurements of acetabular wear in bipolar hemiarthroplasties and measurements of periprosthetic bone mineral density in cemented and uncemented hemiarthroplasties in patients with femoral neck fractures.

Null hypothesis: No difference in acetabular wear or in bone mineral density changes between cemented and uncemented hemiarthroplasties

Patients are randomised to treatment with cemented or uncemented bipolar hemiarthroplasty. 1mm tantalum markers are inserted in the pelvis during surgery. RSA X-rays and DEXA measurements conducted postoperatively, after 3 and 12 months. Follow-up visits and clinical examination at 3 and 12 months.

Eligibility Criteria:
Inclusion Criteria:

* Femoral neck fracture
* 65 years or older
* Able to walk independently

Exclusion Criteria:

* Cognitive dysfunction
* Infection
* Fracture caused by malignant disease
Advanced Social Relations Training

Advanced social relations protocol is aimed at young people with autism aged 9-12 years with an intelligence quotient (IQ) ≥ 80. There will be an experimental group in which technology will be used and a control group in which activities will be carried out in the traditional way. The protocol will be carried out once a week for a duration of 45 minutes. The aim is to enhance communication and social skills within the group. A total of 23 sessions are planned. From the first to the third session the participants will acquire skills for communicating and conversing in an appropriate way. Thereafter from the fourth to the eleventh session social stories illustrating scenes from everyday life will be shown, with the aim of learning and managing the dynamics in which they find themselves on a daily basis. At the end of each story shown they will be asked to impersonate the protagonists depicted in the stories, each participant involved in turn will play all the roles shown in the stories, thus working in the mode of role playing.

The last part, which includes sessions from the twelfth to the twenty-third, will be dedicated to the correct and conscious use of social networks with a focus on the risks that can be encountered and the correct ways to make good use of them.


Eligibility Criteria:
Inclusion Criteria:

* diagnosis of autism
* intelligence quotient ≥ 80

Exclusion Criteria:

* presence of other medical disorders
Dermacyd Infantile (Lactic Acid) - Photo Evaluation.

Primary Objective:

To demonstrate the absence of photo irritation and photosensitization potential of the product Dermacyd Infantile (Lactic Acid).


Eligibility Criteria:
Inclusion criteria:

* Phototype Skin I, II, III and IV
* Integral skin test in the region
* Willingness in following the study procedures and to be present in the clinic at the days and scheduled time for medical evaluations and for application of occlusion.

Exclusion criteria:

* Use of Anti-inflammatory, immunosuppressant or anti-histaminic drugs
* Lactation or gestation
* Use of Anti-inflammatory drugs 30 days and/or immunosuppressant drugs during 3 months before the selection
* Diseases which can cause immunity decrease, such as HIV, diabetes
* Previous atopy
* History of sensitivity or irritation for topic products
* Active cutaneous diseases which can interfere in the study results
* Use of new drugs and/ or cosmetics during the study
* Cutaneous reactivity
* Previous participation in studies, which had used the product
* Volunteers who have immunodeficiency congenital or acquired.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Trans-cutaneous Vagal Nerve Electrical Stimulation and Irritable Bowel Syndrome

This pilot study plan to investigate the sympathovagal balance in women affected by Irritable Bowel Syndrome (IBS), and to evaluate the effect of 6 months of trans-cutaneous vagal nerve electrical stimulation on digestive physiology (intestinal transit time, intestinal mucosal permeability, systemic and local inflammation), symptoms and quality of life.

The safety of the electrical stimulation of the left vagal nerve will also be evaluated.

Ten women, age between 18 and 60, will be included.


Eligibility Criteria:
Inclusion Criteria:

* women aged 18-60,
* clinical Rome III criteria for IBS

Exclusion Criteria:

* pregnancy,
* low intensity symptoms (Francis score between 75-150)
* IBD, coeliac disease
* past history of abdominal surgery (appendectomy and cholecystectomy allowed)
* chronic use of analgesics, anti-depressants
Effects of Flourish on Recurrent Urinary Tract Infection

An over-the-counter vaginal care system is being tested to see if it may be effective in preventing recurrence of symptomatic urinary tract infection (UTI) in women who have had multiple UTIs within the past year.

Women who have a urinary tract infection (UTI) may experience a recurrence within weeks or months of treatment. Some women may experience 8 or more UTIs in a single year, leading to multiple rounds of antibiotics, with the individual risks to organs and risk of antibiotic resistance growing with each round. Alternative methods for prevention of recurrent UTI is therefore desirable. This study will test whether women who use a commercially available, over-the-counter vaginal care system may be able to reduce recurrences of UTI over a six-month period. This is a pilot study designed to determine whether a larger randomized controlled trial in the future would be justified.

Eligibility Criteria:
Inclusion Criteria:

1. Premenopausal cis women aged 18-52 who are in generally good health
2. History of at least 2 UTIs in the past six months, or three prior UTIs in the past year, documented in the medical record. At least one must be culture-proven.

Exclusion Criteria:

1. Pregnant or trying to become pregnant
2. Lactating
3. Immunosuppressed
4. Known allergies to aloe vera or to other components of Restore®, Balance or BiopHresh®
5. Known vaginal infection other than BV or yeast infection at time of screening
6. Women who have needed changes to medical intervention or in-office procedures in the last 3 months
7. Women using vaginal acidifying agents or spermicides for contraception
8. Women who wear a pessary
Study of Guselkumab and Ustekinumab Following a Single Intravenous or Subcutaneous Administration in Healthy Chinese Participants

The purpose of this study is to evaluate the pharmacokinetics (PK) of guselkumab following a single intravenous (IV) or subcutaneous (SC) administration in healthy Chinese participants; to evaluate the PK of ustekinumab following a single IV administration in healthy participants.


Eligibility Criteria:
Inclusion Criteria:

* Participants must be healthy with no clinically significant abnormalities as determined by medical history, physical examination, blood chemistry assessments, hematologic assessments, urinalysis, measurement of vital signs, and electrocardiogram (ECG)
* A woman must have a negative highly sensitive serum (beta-human chorionic gonadotropin \[beta-hCG\]) at screening and Day-1
* Must agree to use an adequate contraception method as deemed appropriate by the investigator; to always use a condom during intercourse and to not donate sperm during the study and for 16 weeks after study drug administration
* Must be a nonsmoker or agree to smoke no more than 10 cigarettes or 2 cigars per day throughout the study. However, during the inpatient portion of the study if smoking is not allowed in the inpatient unit, smokers will not be allowed to smoke cannot use nicotine replacement products
* Must agree to abstain from alcohol intake 48 hours before study drug administration and during the inpatient period of the study. After this time, participants must not consume more than 10 grams of alcohol (e.g. 250 milliliter (mL) beer with 5 percent (%) alcohol content) per day for the duration of the study

Exclusion Criteria:

* History of or current clinically significant medical illness including (but not limited to) cardiac arrhythmias or other cardiac disease, hematologic disease, coagulation disorders (including any abnormal bleeding or blood dyscrasias), lipid abnormalities, significant pulmonary disease, including bronchospastic respiratory disease, diabetes mellitus, renal or hepatic insufficiency, thyroid disease, neurologic or psychiatric disease, infection, gastro-intestinal disease, or any other illness that the investigator considers should exclude the participant or that could interfere with the interpretation of the study results
* Has had major surgery, (for example, requiring general anesthesia) within 12 weeks before screening, or will not have fully recovered from surgery, or has surgery planned during the time the participant is expected to participate in the study
* Has known allergies, hypersensitivity, or intolerance to guselkumab or its excipients
* Has received an experimental antibody or biologic therapy within the previous 6 months
* Has a history of, or ongoing, chronic, or recurrent infectious disease, including but not limited to, chronic renal infection, chronic chest infection, recurrent urinary tract infection
Bedside Assessment of Fall Risk in Emergency Department Elders

The purpose of this study is to assess the risk for falls among elderly Emergency Department (ED) patients.This study will use 2 tests of balance, the Bertec Balance Screening Test and the "Up and Go" test. These tests measure how steady a person is while standing, walking, and turning 180 degrees. After patients have returned home, they will be contacted at 7 days, 30 days and 6 months to determine if they have sustained a fall during these intervals in order to find out how predictive the balance tests are in determining the risk of future falls.

Falls are one of the most significant health risks to older Americans. In the U.S., 30-60% of community dwelling elders will fall each year.Studies have found rates of serious injury among elders who fall to range from 5-24%. Five percent of those who fall are hospitalized. Among elders, falls cause 2/3 of the deaths due to unintentional injury, the 6th leading cause of death in this age group. Additional major morbidity due to falls includes loss of independence as well as anxiety due to fear of falling. This results in limitation of function and often in a requirement for long-term care. Up to 40% of nursing home admissions are due to falls or fear of falling. Expenditures for fall-related injuries account for 6% of all medical expenditures in geriatric patients. Several interventions have been proven effective to reduce rates of fall. Implementation of these interventions requires physician appreciation of the risk for falls in individual patients. The emergency department (ED) may provide a location to identify patients at increased risk of falling. Unfortunately, successful ED based studies to identify and intervene on at-risk elders have been rare and not widely reproducible. The results of these previous ED studies demonstrate that a rapid, efficient, measurable assessment of balance is required if emergency physicians are to regularly consider such factors in their care plans and disposition decisions. Development of a single, simple screening test to identify ED elders at who fall may improve falls screening in the ED and prevent unnecessary morbidity and mortality by facilitating early identification and intervention.

Eligibility Criteria:
Inclusion Criteria:

* Age \> 59 years
* Discharge from Emergency Department
* Self-reported weight \< 300 pounds
* Patient resides in the community or a personal care home
* Patients must also confirm that they are able to walk 30 feet without help of another person.They may do this with use of an assistive device.

Exclusion Criteria:

* Age \<60 years
* Subject is incarcerated
* Non-English speaking
* Lack of ability of patient to give consent or complete the study tasks
* Patient resides in a nursing home or rehabilitation facility
* Primary evaluation by the trauma team
* Inability to walk 30 feet without assistance from another person
PADN to Treat Severe Obstructive Sleep Apnea

This project is focused on the treatment of severe obstructive sleep apnea with pulmonary artery denervation (PADN). Although it has now been proved that continuous positive airway pressure (CPAP) is the primary treatment for obstructive sleep apnea, on the other hand, there is evidence that 25 to 50% of patients can not tolerate CPAP.

The investigators previously reported the safety and efficacy of pulmonary artery denervation (PADN) for treatment of pulmonary hypertension. Excessive sympathetic activation play an important role in the occurrence and development of OSA and cause cardiovascular events. It is worth evaluating the feasibility and tolerance of introducing PADN at the severe stage of obstructive sleep apnea. Therefore, the purpose of our study is to evaluate the safety and feasibility of PADN in the treatment of severe OSA.


Eligibility Criteria:
Inclusion Criteria:

* Apnea hypopnea index more than 30, not tolerated or refused continuous positive airway pressure;

Exclusion Criteria:

* Acute coronary syndrome;
* Pregnant;
* Expected life less than 12 months;