cyrilzakka/clinical-trials huggingface dataset:
Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer

This study is designed to evaluate the short-term and long-term results after single incision laparoscopic surgery for colorectal cancer（SILSC） compared with conventional laparoscopic surgery for colorectal cancer（CLSC）.

In order to improve cosmetic effect and reduce postoperative pain, single-incision laparoscopic surgery (SILS) is attracting increasing attention. SILS is considered to be the next major advance in the progress of minimally invasive surgical approaches to colorectal disease that is more feasible in generalized use. In most previous studies, SILS for colorectal cancer was feasible and short-term safe compared to conventional laparoscopic surgery (CLS) . However, there is still controversy over its potential better cosmetic effect and less postoperative pain. Moreover, the long-term oncologic outcomes are still inconclusive as only a few studies showed long-term survival data. Up to now, most studies were limited to their retrospective nature and small samples. So more studies, especially large-scale, randomized controlled trials are needed to establish the best indications for SILS for colorectal cancer.

Eligibility Criteria:
Inclusion Criteria:

* Inclusion Criteria:
* 18 years \< age ≤85 years
* Tumor located in colon and high rectum ( the lower border of the tumor is above the peritoneal reflection)
* Pathological colorectal carcinoma
* Clinically diagnosed cT1-4aN0-2 M0 lesions according to the 8th Edition of AJCC Cancer Staging Manual
* Tumor size of 5 cm or less
* ECOG score is 0-1
* ASA score is Ⅰ-Ⅲ
* Informed consent

Exclusion Criteria:

* Body mass index (BMI) \>35 kg/m2
* The lower border of the tumor is located distal to the peritoneal reflection
* Pregnant woman or lactating woman
* Severe mental disease
* Previous abdominal surgery（except appendectomy and cholecystotomy）
* Emergency operation due to complication (bleeding, perforation or obstruction) caused by colorectal cancer
* Requirement of simultaneous surgery for other disease
Oral Penicillin Challenge and Allergy De-labeling in Children

The primary purpose of this study is to investigate the portion of penicillin allergy labels that are not true allergies using oral amoxicillin challenges among pediatric patients. The secondary purpose is to evaluate the safety and feasibility of administering oral penicillin allergy challenges in the Pediatric Emergency Department.


Eligibility Criteria:
Inclusion Criteria:

1. Patients in the pediatric emergency department who are 2-17 yo and labeled as penicillin-allergic (including amoxicillin or other penicillin allergies)
2. Patients at low risk of anaphylaxis as determined by the study questionnaire
3. Patients who would normally be prescribed amoxicillin, amoxicillin-clavulanate or another penicillin for their current bacterial infection, including otitis media, Group A Streptococcal pharyngitis, pneumonia. sinusitis, dog and cat bite wounds, regimens for Helicobacter pylori eradication, or other acute infections deemed susceptible.
4. Patients who are interested in participating
5. Patients who have an acceptable surrogate to give consent on the subject's behalf
6. Patients whose surrogate (parent/caregiver) speaks English or Spanish

Exclusion Criteria:

1. Patients who are uninterested in participating, or their parents/caregivers are not interested in having them participate
2. Patients who have multiple drug allergies
SU011248 In The Treatment Of Patients With Bevacizumab (Avastin)-Refractory Metastatic Renal Cell Carcinoma

The purpose of this study is to test whether sunitinib (SU011248) has activity and is safe in patients with renal cell carcinoma (RCC) who have failed prior therapy with bevacizumab (Avastin) -based treatment.


Eligibility Criteria:
Inclusion Criteria:

* Histologically proven renal cell carcinoma of clear cell histology with metastases
* Evidence of measurable disease
* Radiographic evidence of disease progression during or within 3 months of completion of bevacizumab-based treatment
* Prior radical or partial nephrectomy

Exclusion Criteria:

* Prior treatment with any other anti-angiogenic therapy other than bevacizumab
* Prior systemic treatment for RCC \> 2 regimens
* History of or known brain metastases
* Serious acute or chronic illness or recent history of significant cardiac abnormality
Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)

Individuals with spinal cord injury sustain significant loss of bone mass in their lower extremities (20-40% or more). This study evaluates the ability of PTH and weight-bearing, two interventions that build bone, to increase bone mass in this population.

This pilot project aims to evaluate PTH with weight-bearing in a group of individuals with chronic SCI and loss of bone mass in their lower extremities. A convenience sample of 12 people with SCI will be enrolled into a 6 month study assessing the effects of a weight-bearing regime plus daily PTH (Forteo 20ug sc) on BMD and bone markers. Subjects will be evaluated at 3 and 6 months after initiating treatment with measurement of bone density as well as bone markers of formation and resorption. An optional extension to 12 months will be offered to all subjects.

Eligibility Criteria:
Inclusion Criteria:

1. Age 18-75 years
2. Complete SCI - total loss of motor function below level of lesion
3. Capable of positioning to have DEXA performed
4. Capable of undertaking the weight-bearing exercise regime
5. Capable of reading and understanding informed consent document
6. Able to self-administer PTH or have someone in the family who can do so
7. T score \<-2.5 or Z score \<-1.5 on evaluation of total hip BMD
8. No known endocrinopathies
9. Normal TSH levels
10. Normal 25-OH vitamin D levels
11. Normal calcium levels
12. Normal renal function (creatinine \<2.0mg/dl)
13. Able to return for all follow-up visits

Exclusion Criteria:

1. Surgical or other intervention resulting in metal or anatomy precluding obtaining DEXA and/or MRI measurements
2. Other medical conditions that in the opinion of the investigator would preclude the subject from completing the study
3. History of malignancy
4. History of radiation therapy
5. Unable to self-administer PTH or have it administered
6. Elevated liver function tests \>2x normal
7. For males, significantly abnormal free testosterone levels
8. Currently being prescribed anti-convulsants
9. Currently being prescribed glucocorticoids, other than inhaled glucocorticoids
10. Currently being prescribed any bone-active agents, including any bisphosphonate, raloxifene, hormone therapy (estrogen and estrogen/progestin), calcitonin or strontium-containing compounds.
11. No previous history of bisphosphonate use
12. No previous use of other bone-specific agents during past 2 years
Prevention and Pharmacological Management of Cardiac Adverse Drug Reactions Induced by Drugs Used in Oncology.

Recently, the medical management of cancer patients has considerably improved the prognosis of these patients and today some cancers are becoming "chronic diseases". As a result, new adverse effects (AEs) are observed, particularly cardiac.

These "new" cardiac AEs are the consequence of a significant increase in patients life expectancy (delayed AEs not previously seen) but also the use of new pharmacological classes of anticancer drugs such as kinase inhibitors. The incidence of these cardiac AEs varies according to the patient profile and the anticancer molecules used, but their impact on the morbidity and mortality of the patients is significant.

In this context, we started at the University Hospital of Caen Normandy in September 2017 a cardio-oncology program entitled "prevention and pharmacological management of cardiac adverse effects induced by drugs used in Oncology" (PICARO program). This program involves the pharmacology department (opening of a dedicated consultation), the cardiology department (opening of a dedicated ultrasound consultation), vascular medicine departement (opening of a dedicated consultation) and the oncology federation. This program aims to be regional in the future. We therefore propose to build a cohort backed up to the PICARO program to assess the regional impact of cardiac AEs of anticancer drugs and thus to be better able to specify the number of AEs, the incidence and regional prevalence of these drugs. .

The constitution of this cohort is only the first step towards the constitution in the near future (2 years) of an observatory and then a regional registry of cardiac AEs induced by anticancer drugs. The objectives associated with the establishment of such a registry would be to reduce the number of cardiac AEs, the hospitalizations caused by these AEs, a better information of health professionals and patients, an improvement in the screening of patients at risk, all coming back in the context of health, clinical, epidemiological and pharmacological surveillance.


Eligibility Criteria:
Inclusion Criteria:

* Patient ≥ 18 years,
* Attents of cancer,
* Addressed for the first time to one of the PICARO program consultations at the University Hospital of Caen Normandy,
* Written informed consent,
* Patient beneficiary of the french social insurance.

Exclusion Criteria:

* Minor and major protected patients
* pregnant or nursing women
* patient already included in the PICARO cohort
* Patients under guardianship, curatorship, safeguard of justice or legal protection.
Breathing Techniques and Meditation for Health Care Workers During COVID-19 Pandemic

This phase I trial investigates breathing techniques and meditation for health care workers during COVID-19 pandemic. Breathing techniques and medication may help manage stress and improve lung health. The goal of this trial is to learn if breathing techniques and meditation may help to reduce stress and improve lung health in health care workers during the COVID-19 pandemic.

PRIMARY OBJECTIVE:

I. To demonstrate the feasibility of a short pranayama or breathing techniques and meditation during Covid-19 pandemic.

SECONDARY OBJECTIVES:

I. To determine the adherence to the practice assessed as at least 50% of participants implement the intervention for 3 or more times in a week by the end of week 1/day 7 (+ 3 days).

II. To determine the change in resilience, perceived stress and psychological impact from day 0 today 28 as measured by the Brief Resilient Coping Scale (BRCS), Perceived Stress Scale (PSS4), and COVID-19 Stress among health care workers questionnaire.

III. To determine the changes in breath holding time measured weekly for 4 weeks.

IV. To determine the differences in breath holding time between those who are adherent and those who are not adherent to the practice.

OUTLINE:

Patients view an instructional video on breathing techniques and meditation. Patients then perform breathing techniques over 3 minutes and meditation over 2 minutes twice daily (BID) for 28 days.

Eligibility Criteria:
Inclusion Criteria:

* Participants must be able to read and understand English
* Must be employed at MD Anderson Cancer Center

Exclusion Criteria:

* Epilepsy
* Brain tumor
* Brain aneurysm
* Pregnant or trying to get pregnant
* Brain bleeding in the past 1 year
* Recent abdominal surgery and not cleared to exercise
Trial of Decongestive Lymphatic Therapy for Lymphedema in Women With Breast Cancer "DELTA STUDY"

The purpose of this study is to evaluate the efficacy, safety and impact on quality of life of decongestive lymphatic therapy (DLT) in women who have completed treatment for breast cancer and present with lymphedema.

This is a multicentre trial enrolling 100 patients randomized to receive conservative care for arm lymphedema (Canadian Guidelines) with or without decongestive lymphatic therapy performed by a professional who has received training and certification in the technique of lymphatic draining massage.

Duration: One year after the last patient is randomized.

Randomized patients receive either standard of care or standard of care plus DLT (five massage sessions per week for 4 consecutive weeks). Primary evaluation of all patients is recorded six weeks after randomization by measuring the affected limb and comparing with the unaffected one. There is an extended follow-up of one year.

Eligibility Criteria:
Inclusion Criteria:

* Women with a histological diagnosis of breast cancer experiencing edema in the ipsilateral arm such that there is a minimum 15% increase in arm volume over the opposite arm.
* Patients must have completed all primary and adjuvant treatments (surgery, chemotherapy, radiotherapy) prior to randomization. This is to ensure that scheduling difficulties with daily treatments do not arise. Patients may be currently taking tamoxifen or similar hormonal treatment.

Exclusion Criteria:

* Clinical or radiological evidence of active disease, either local or metastatic.
* History of contralateral cancer, axillary surgery, radiation or bilateral arm edema. (Edema volume will be taken as the increase in volume compared to the unaffected arm; previous therapy in the opposite arm will reduce the accuracy of measuring excess volume related to lymphedema.)
* Previous surgery involving nodal dissection or radiotherapy to other major node-bearing areas in the body such as the mediastinum or pelvis. Disruption of lymphatic flow in these potentially alternate routes may be compromised by such interventions. Patients are eligible after a simple hysterectomy (+/- oophorectomy).
* Previously undergone massage therapy for arm edema, or has used compression sleeve within the last month.
* Serious non-malignant disease, such as renal or cardiac failure, which would preclude daily treatment and follow up.
* Patients for whom massage is contraindicated, such as those with untreated infections or thromboses in the affected arm.
* Unable to commence therapy within 7 days of randomization.
* Psychiatric or addictive disorders which preclude obtaining informed consent or adherence to the protocol.
The Kunshan Elderly Health Study

The Kunshan Elderly Health Study (KEHS) is a community-based prospective cohort study of chronic disease, mortality and associated factors among elderly adults in Kunshan, Eastern China.

The Kunshan Elderly Health Study (KEHS) is a project organized by the Soochow University, in collaboration with the Kunshan \& Suzhou Centers for Disease Control and Prevention. It was primarily designed to assess risk factors (nutritional, metabolic, lifestyle, etc.) for chronic diseases and mortality among community residents aged 65 years and above, and explore effective intervention measures, so as to ultimately reduce the burden of disease and promote healthy aging. In addition, findings of this study would contribute to further understanding of pathogenesis of the chronic diseases and provide new ideas for precise prevention, drug development and risk prediction.

Eligibility Criteria:
Inclusion Criteria:

* Locally registered-residents in Kunshan
* Aged 65 years or above
* Voluntary agreement to participate in the study (with written informed consent)

Exclusion Criteria:

* Patients with stroke, coronary heart disease or cancer
* Patients with severe physical or mental illness
* People unable to complete the survey
Benefits of the Xiaxi Postural Hammock and a Xiaxi Exercise Program

Chronic low back pain is one of the main causes of pain, dysfunction and disability worldwide. In Spain, 93% of the population has had back pain in the last year, and it is estimated that 50% of sick leave is due to this cause. This entails a great socioeconomic burden, since it is the main cause of absenteeism from work and the excessive use of therapeutic services.

Musculoskeletal disorders are related and associated with psychologically stressful jobs, that is, with psychosocial factors at work and related work stressors, such as time pressure, low job control, poor social or supervisor support, effort-reward imbalance or work-life conflict. Clinical management of both situations encompasses a variety of approaches, including medication and early physical exercise, which have shown promise in reducing pain and improving function.

A novel approach to address these problems is the use of Xiaxi, a patented postural hammock with multiple angles of inclination that promotes relaxation and elongation of the posterior chain, thereby improving overall well-being. Combining the use of Xiaxi with a comprehensive program of strengthening, stretching and relaxation exercises could offer benefits in the prevention and reduction of back pain.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years.
* Presence of back pain.

Exclusion Criteria:

* Have undergone surgery of the spine, ischiosural muscles, psoas-iliac, pectoral and rotator cuff.

  * to have any structured spinal spine alteration diagnosed by health personnel.
  * have had a rupture of the ischiosural, psoas-iliac, pectoral and rotator cuff muscles in the last year or during the intervention.
  * have any type of injury that prevents you from performing the initial assessment in the first week of the procedure.
  * to have practiced vigorous physical exercise on the day of the investigation or 24 hours before the initial or final assessment.
  * having eaten large meals on the days of the investigation
  * less than two hours had elapsed since any prolonged recumbent rest at the start of the assessment.
Study on High-sensitivity Troponin 0h/1h for Rapid Diagnosis of Non-ST-segment Elevation Myocardial Infarction in the Chinese Population

The purpose of the study is to establish a high-sensitivity troponin 0h/1h process for the diagnosis of patients suspected of NSTEMI for the Chinese population, obtain the inclusion and exclusion criteria for diagnosis of these patients and compare the new process with the existing diagnosing methods and processes, including the 3h and 6h processes more extensively used at present and the ECG combined with troponin diagnosis, so as to explore a confirmation model suitable for the Chinese population.


Eligibility Criteria:
Inclusion Criteria:

1. Patients experiencing acute chest pain or angina pectoris symptom within 12 hours before visiting the hospital;
2. Or those experiencing acute chest pain or angina pectoris peak within 12 hours before visiting the hospital.

Exclusion Criteria:

Patients showing ST-segment elevation during ECG and pregnant women.
Domain-general and Domain-specific Contributions to the Development of Numerical Cognition

Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention. Recorded fMRI.

Using T2\*-weighted eip imaging, we measured BOLD response in two cohorts of healthy children while they were doing different cognitive tasks in the scanner. These tasks included solving non-symbolic (i.e. sets of elements) and symbolic (i.e. Arabic digits) addition and subtraction problems, a color control task, an attentional task measuring different facets of spatial attention, and a task measuring inhibition. We also recorded a high-resolution anatomical scan of the brain.

Eligibility Criteria:
Inclusion Criteria:

* school enrollment
* French as mother tongue
* right-handed
* normal medical, neurological and neuroradiological examinations - parents affiliated to a social security scheme

Exclusion Criteria:

* not within age range
* monocygotic twins
* - contraindications to an MRI examination (neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nerve structures, metal prostheses, patient agitation: uncooperative or agitated patients, claustrophobic subjects, ventriculoperitoneal neurosurgical shunt valves, dental apparatus, etc.).
* sudden onset of cognitive problems that could indicate a stroke; a history of head trauma with loss of consciousness lasting more than 1 hour, or encephalitis; - a chronic neurological, psychiatric, endocrine, hepatic or infectious condition
* a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrinological or immunological disorders, cancer); - medication likely to interfere with brain imaging measurements
* color blindness or uncorrected visual disorders
* inability to take part in the study for geographical or psychiatric reasons
* presence of pervasive developmental and/or acquisition disorders identified by parents or legal guardians and/or teachers
* cerebral palsy
* impaired fine motor skills
* parents or legal guardians not affiliated to a social security scheme
* unaccompanied by parent(s) or legal guardian(s) during visits.
* tattoo not compatible with MRI
* children and parents under legal protection
The Effects of Lower Body Resistance Training on Balance and Fall Prevention in the Elderly

The aim of the study is to prevent falls related to poor lower body strength adn balance in the elderly.

The purpose of the study is to determine the effects of a structured lower body resistance training program on balance in an elderly population. Our hypothesis is that elderly adults will improve their balance following a structured lower body strength training program compared to those who do not engage in a lower body strength training program.

Eligibility Criteria:
Inclusion Criteria:

* Healthy male and female adults 65 or older with physician consent to participate

Exclusion Criteria:

* Unable to obtain physician consent to participate
Efficacy and Safety of PRC-4016 in Subjects With Mixed Dyslipidemia

The objective of this study is

* To evaluate the efficacy of PRC-4016 by assessment of the percentage change in blood lipids and lipoprotein parameter from baseline after 12 weeks of treatment
* To evaluate the safety of PRC-4016 as assessed by adverse events and other safety parameters

6-8 weeks screening period with diet/lifestyle stabilization and lipid qualification

Eligibility Criteria:
Main Inclusion Criteria:

* Fasting triglycerides 200-499 mg/dl
* Non-HDL-C \> 130 mg/dl
* Stable statin treatment

Exclusion Criteria:

* Type I diabetes or uncontrolled type II diabetes
* Recent cardiovascular or coronary event
* History of pancreatitis
* History or evidence of major and clinically significant diseases that would interfere with the conduct of the study or interpretation of data
* Uncontrolled hypertension