cyrilzakka/clinical-trials huggingface dataset:
Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD

The purpose of the study is to examine the developmental trajectory of response control in boys and girls with ADHD entering adolescence. The investigators also want to determine the developmental trajectory of brain anatomy and brain connectivity in boys and girls with ADHD entering adolescence.

Children with Attention Deficit Hyperactivity Disorder (ADHD) are at risk for a host of deleterious outcomes including impaired social relations, academic difficulties, criminality, and comorbid psychopathology (substance use, depression, anxiety). Many of these difficulties emerge and exacerbate during adolescence; therefore, it is crucial to understand the developmental trajectory of ADHD-associated changes in brain and behavior during this sensitive period. Further, there is increasing recognition that sex may be an important moderator of the clinical manifestations of ADHD, with adolescent boys showing more impulsive risk-taking while girls show more emotional dysregulation.

Identification of patterns of brain and behavioral development associated with risk for poor outcome in both boys and girls with ADHD shows the profound public health significance of our research. Furthermore, the investigators are proposing to examine the dimensional construct of response control in children with ADHD from multiple levels of analysis including neural structure and connectivity, behavioral expression, and relation to functional outcomes, with the ultimate goal of identifying bio-behavioral markers of impairment and adjustment in children with ADHD.

Our objectives:

Aim 1: To examine the developmental trajectory of response control in boys and girls with ADHD entering adolescence.

Aim 2: To examine how baseline abnormalities in response control and brain structure and function, as well as development trajectories for these measures, differentially predict functional outcomes in adolescent boys and girls with ADHD.

Aim 3: To examine how intrinsic functional connectivity relates to brain structure, structural connectivity, and response control in adolescent boys and girls with ADHD.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with or without Attention Deficit Hyperactivity Disorder
* Must be able to attend a follow-up after 18 months after initial visit

Exclusion Criteria:

* Diagnosed with Autism Spectrum Disorder (ASD)
* Diagnosed with Schizophrenia, Conduct Disorder, and/or Bipolar Disorder
* Diagnosed with a genetic disorder
* Premature birth (less than 36 weeks)
The PIV5Rights Safety and Quality Bundle

Purpose of this study is to see if a Peripheral Intravenous Catheter PIVC will last longer if inserted by a Registered Nurse (RN) who specializes in inserting PIVCs. Main question it aims to answer:

1. We believe that the use of the ultrasound, an RN who specializes in PIVC placement with the use of ultrasound and the use of best of class medical technology, may improve first stick success with PIVC insertion and the length of time the PIVC stays in place without showing any related complications

After being informed about the study and potential risks, all patients giving written informed consent, patients will be randomized using Research Randomizer. At that time, the IV Therapist will insert a PIVC using standard of care medical equipment (control) or use ultrasound guidance, if needed, to insert a PIVC using the bundle with the best of class medical devices. Daily, a research RN will round, assess the site and take a picture. When therapy is complete or the PIVC malfunctions, the research RN will document the reason why the PIVC failed and that patient will no longer remain in the study.

Eligibility Criteria:
Inclusion Criteria:

* 18 years or older with not upper limit
* requires an IV for fluid and or medication administration
* able to read and write English and willing to complete written, informed consent

Exclusion Criteria:

* Unable to speak and read English
* Vulnerable populations such as minors (under age of 18)
* Incompetent or mentally challenged
* Prisoners
* Pregnant women or the unborn
* presented in the hospital prior to study start date
To Identify KRAS Gene and Safe Margin in Association With Outcome in Colorectal Liver Metastases Following Ultrasound-guided Radiofrequency Ablation

To investigate the clinical effect of radiofrequency ablation on colorectal cancer liver metastases with different KRAS gene status


Eligibility Criteria:
Inclusion Criteria:

1. Diagnosed as liver metastasis of colorectal cancer;
2. There are no more than 3 liver metastases and all the lesions are not more than 5 cm; or no more than 6 liver metastases and all the lesions are not more than 3.0 cm;
3. The primary lesion of colorectal cancer has been treated curatively or is planned to undergo curative treatment;
4. KRAS gene test results can be obtained for primary or metastatic foci;
5. Signing informed consent voluntarily;
6. Men or women who have reached the age of 18;
7. Ultrasound or ultrasound contrast can clearly show the lesion and guide RFA treatment;
8. Platelet count\> 50,000/mm3, prothrombin activity\> 50%;
9. Child-Pugh grade A or B of liver disease, but no hepatic encephalopathy or/and ascites;
10. Subjects are willing to return to the research center for research follow-up;
11. Life expectancy ≥ 6 months-

Exclusion Criteria:

1. suffer from but not limited to the following serious diseases: congestive heart failure, myocardial infarction or cerebrovascular accident, or life-threatening arrhythmia in the past 6 months;
2. During pregnancy or lactation. Before receiving research treatment, women of childbearing age must have a negative serum pregnancy test;
3. Any known allergic reactions to the intravenous imaging agent used in this study;
4. There is portal vein or hepatic vein tumor infiltration/carcinoma;
5. International normalized ratio of prothrombin\> 1.5 times the upper limit of normal value (UNL) of the research center;
6. Platelet count \<50,000/mm3, absolute neutrophil count \<1500/mm3, or heme value \<10.0g/dL;
7. Serum creatinine ≥2.5mg/dL or calculated creatinine clearance (CrCl) ≤25.0ml/min;
8. Serum bilirubin\>3.0mg/dL;
9. Serum albumin \<2.8g/dL;
10. Body temperature \>101°F (38.3°C) immediately before study treatment;
11. being treated with other research drugs;
12. Heart failure NYHA function grade is III or IV .
Efficacy of First MTPJ Arthrodesis as a Treatment in Hallux Rigidus

A randomised, controlled trial will be performed by allocating 40 years or older patients with symptomatic hallux rigidus to arthrodesis or watchful waiting group in a ratio of 1:1. Our primary outcome will be pain during walking, assessed by the 0-10 Numeric Rating Scale (NRS) at one year after randomisation. Our secondary outcomes will be pain in rest (NRS), physical function (MOXFQ), patient satisfaction in terms of Patient-accepted Symptom State (PASS), health-related quality of life (EQ-5D-5L), activity level (The Foot and Ankle Ability Measure Sports subscale), use of analgesics or orthoses and rate of complications. Our null hypothesis is that there will be no difference between arthrodesis and watchful waiting in treatment of hallux rigidus. Our primary analysis will be done using intention-to-treat principle.


Eligibility Criteria:
Inclusion Criteria:

* Age 40 years or over
* Diagnosis of hallux rigidus: Persistent pain on movement of the first MTPJ AND Osteoarthritic first MTPJ in plain X-rays
* Duration of symptoms ≥1 year
* Pain-NRS during walking of 4 or more on a scale 0-10 (higher is worse)
* No substantial pain in other joints of the foot in clinical examination
* Willingness to accept both treatment options
* Ability to understand trial information and answer outcome assessments in Finnish
* Signed informed consent

Exclusion Criteria:

* ASA\* physical status classification level III or higher
* Patients with weak co-operation (dementia, schizophrenia, etc.)
* Patients with neuropathy, i.e. unable to feel 10g monofilament pressure in less than 8 out of 10 standard testing sites
* Active bacterial infection or ulcer of the lower limb
* Diabetes mellitus with insulin treatment
* Diabetes mellitus and GHb-A1C \>64 mmol/mol (regardless of treatment)
* History of rheumatoid arthritis, gout or other inflammatory arthritis of the foot
* Hallux valgus angle \>15° in weight-bearing X-ray
* Hallux varus in weight-bearing X-ray
* Large bone cysts in X-ray probably requiring bone grafting in surgery
* Pain in passive manipulation of ipsilateral first toe IP joint
* Patients with severe circulatory disorder of the lower limb: absence of palpable pulses in the foot (both dorsalis pedis artery and tibialis posterior artery)
* History of surgery of the foot in question
* Neuropathic pain of the foot in question (i.e., use of neuropathic analgesics)
* Activity limiting symptoms from an earlier fracture or ligament injury of the foot
* Patient is not willing to accept the operation within the planned time limits (3 to 12 weeks post-randomisation)
Enhancement of Methylphenidate Treatment by Psychosocial Intervention and Support

The main purpose of this study is to evaluate the effectiveness of a parenting enhancement training (PET) for parents with children diagnosed with Attention Deficit-/Hyperactivity Disorder (ADHD) who are already medicated with methylphenidate.

The main purpose of this study is to evaluate the effectiveness of a parenting enhancement training (PET) for parents with children diagnosed with Attention Deficit-/Hyperactivity Disorder (ADHD) already medicated with methylphenidate (MPH). This particular PET was developed at the Department of Child and Adolescent Psychiatry and Psychotherapy at the University of Cologne and has already been evaluated in several studies. MPH treatment has been proven to be efficacious in the reduction of ADHD symptoms. However, despite optimal titration a substantial percentage of children still suffer from residual symptoms and impairment in psychosocial functioning. Therefore, there is still room for improvement in satisfaction with medication. Moreover, a substantial rate of patients with good treatment effects fails to comply with medication during the course of treatment. This parenting enhancement training (PET) mainly conducted via written materials and telephone support will be introduced in patients already treated with MPH. Effects are expected on symptoms of ADHD as well as on comorbid oppositional symptoms. Further outcome parameters are satisfaction with medication and medication compliance of MPH treatment, psychosocial functioning as well as parenting skills. Parenting skills are a main focus of the PET and ADHD symptoms shall be improved through improving parenting skills. Besides focusing on symptoms, recent research often focuses on improvement of quality of life and impairment in psychosocial functioning (e. g. family, school, leisure time) as well. Not only suffer patients from the main symptoms. Many patients suffer as well from the symptoms' consequences, which is often an overall impairment. Satisfaction with medication and medication compliance are fundamental conditions for the success of a long term medical therapy. However, many studies show a lack of compliance.

Eligibility Criteria:
Inclusion Criteria:

* The child attends school and is aged 6 to 12
* Primary diagnosis of ADHD
* Medication with methylphenidate in stable doses for at least two months
* Currently, no change of medication is planned
* The parents are motivated to participate in the parenting enhancement training
* The parents have a command of written and spoken German
* Psychosocial impairment measured with WFIRS-P

Exclusion criteria:

- the family takes presumably part in psychotherapy with an intensive parenting training component during the duration of the intervention
Electrical Impedance Imaging of Patients on Mechanical Ventilation

The goal of this study is to evaluate the sensitivity and specificity of Electrical Impedance Tomography (EIT) as a bedside diagnostic tool for lung pathologies in patients who are mechanically ventilated. In electrical impedance tomography low amplitude, low frequency current is applied on electrodes, and the resulting voltage is measured and used to computed the electrical properties of the interior of the chest as they change in time. The computed properties are used to form an image, which can then be used for monitoring and diagnosis.

The goal of this study is to characterize the ability of the electrical impedance tomography system (hardware and software) to distinguish between lung pathologies by assessing the sensitivity and specificity as well as the overall agreement with the CT scan in terms of spatial resolution. The study will test, as well as refine, the mathematical algorithms needed to create meaningful outputs on adult patients receiving mechanical ventilation and who also have received or will be receiving a CT scan as part of their standard of care.

Eligibility Criteria:
Inclusion Criteria:

* Patients admitted to the ICU at Medical Center of the Rockies and on mechanical ventilation
* Age greater than or equal to 18
* Computed Tomography of the chest during normal course of hospital admission

Exclusion Criteria:

* Age \<18
* Any skin disorder that would prevent placement of the electrodes on the chest wall
* Hemodynamic instability prohibiting patient from being moved to place the device
Local Infiltration Analgesia for Hip Arthroscopy

The purpose of this study is to examine if ultrasound guided infiltration of local anesthetic solution around the hip joint will provide effective pain control after hip arthroscopy.


Eligibility Criteria:
Inclusion Criteria:

* hip arthroscopy
* ages 18-80

Exclusion Criteria:

* history of neurological disease
* diabetes
* pregnancy
* neuropathy
* chronic narcotic use
* allergy to local anesthetic solution
* inability to give consent or cooperate with the study protocol
Study of 1cm Versus 2cm Margins for the Surgical Treatment of cT2N0M0 Melanoma

This is a randomized non-blinded pilot study for patients with melanoma staging cT2N0M0 who are candidates for surgical resection. The primary objective is to determine the feasibility of randomizing participants with cT2N0M0 malignant melanoma to surgical treatment with 1cm versus 2cm margins. Study will try to determine overall survival for cT2N0M0 malignant melanoma after surgical treatment with 1cm versus 2cm margins.

After randomization, participants will undergo surgery with wide local excision with either 1cm or 2cm margins. The margin will be based upon the previous biopsy site or area of pigmentation. The skin and subcutaneous tissue (down to fascia) will be resected. Closure considerations may require removal of additional tissue for non-oncologic purposes. As per standard of care, sentinel lymph node biopsy will be performed using a dual tracer technique (technetium radiolabeled sulfur colloid and isosulfan blue) with or without lymphoscintigraphy.

Eligibility Criteria:
Inclusion Criteria:

* Biopsy proven T2 malignant melanoma.
* Eastern Cooperative Oncology Group (ECOG) score of 0-2.

Exclusion Criteria:

* Visible additional disease that suggests a greater than T2 malignant melanoma
* Unable to tolerate general anesthesia
* Evidence of distant metastatic disease
* Melanoma located on face or digits
CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma

T cell lymphoma is a heterogenic malignancy with poor outcome. Five-year PFS and OS of the patients recieved classic CHOP regimen(cyclophosphamide,vincristin,doxorubicin and predisone)is less than 30%.High dose intensive chemotherapy doesn't demonstrate better response. At present, there is no standardized treatment protocol for this kind of lymphoma.

Between 1994 and 1998,the Scotland and Newcastle Lymphoma Group prospectively collected data on newly diagnosed patients with enteropathy associated T-cell lymphoma (EATL)in the Northern Region of England and Scotland,which is a rare and aggressive type of peripheral T-cell lymphoma.The novel regimen IVE/MTX (ifosfamide, vincristine, etoposide/methotrexate)-ASCT was piloted for patients eligible for intensive treatment,followed by auto-stem cell transplantation.Five-years PFS and OS were 52% and 60% respectively, significantly improved compared with the historical group treated with anthracycline-based chemotherapy. The encouraged results were extended to the peripherial T cell lymphoma-non specified(PTCL-nos).

Past studies suggested pirarubicin was more active to the T cell lymphoma than doxorubicin in vitro based on its high concentration in tumor cells. Clinical data also presented equivalent even superior efficacy of pirarubicin with lower toxicity than doxorubicin. The aim of our study is to compare the response and survival rate of CTOP/ITE/MTX (cyclophosphamide, vincristin,pirarubicin and predisone/ ifosfamide, pirarubicin, etoposide/methotrexate) with those of CHOP regimen,looking forward to its superiority in efficacy and safety for the de novo young patients with T cell lymphoma.


Eligibility Criteria:
Inclusion Criteria:

* pathologic verified mature T cell lymphoma,including ALK-negative anaplastic large cell lymphoma,peripherial T cell lymphoma-non specific type,angioimmunoblastic T cell lymphoma,enteropathy associated T cell lymphoma and hepatosplenic T cell lymphoma
* SGOT/SGPT no more than 2 times of UNL
* serum creatinine no more than 1.5 times of UNL
* signed informed consent

Exclusion Criteria:

* woman in pregnancy or lactation
* allergic to any intervention drug
* insuitable to the study due to severe complication
* enrolled to other study during the past 6 months
Impact of Neuromodulation on Language Impairments in Stroke Patients

Up to 40% of stroke survivors suffer from aphasia, making recovery of language abilities a top priority in stroke rehabilitation. Conventional speech and language therapy may have limited effectiveness. Leveraging multimodal data (behavioral, neuroimaging, and genetics), this study aims to 1) evaluate the efficacy of combining tDCS with speech therapy, 2) examine neural changes associated with recovery, 3) identify factors influencing response to treatment.

Approximately one million people in the United States are living with aphasia, an acquired neurological disorder affecting the ability to use and/or understand language. This communication impairment affects up to 40% of stroke patients. Stroke victims usually prioritize speaking, writing, and walking as the three most important rehabilitation goals, two of these goals therefore involving communication. Conventional speech therapy strategies have nevertheless limited effectiveness in post-stroke aphasia. Indeed, approximately half of those affected will remain in this state despite intensive speech therapy. Effective novel treatment is therefore warranted to improve recovery in these patients. Recent evidence suggests that transcranial direct current stimulation (tDCS), a non-invasive, low-cost neuromodulation technique, applied in conjunction with speech therapy may be more effective in promoting language recovery than behavioral intervention alone.

A double-blind quasi-randomized controlled study will be carried out in chronic post-stroke aphasics. Participants will be assigned to either the tDCS group or to the sham (placebo) group and will receive 20 minutes of concurrent speech and language therapy by a trained speech therapist over five consecutive days. Behavioral, EEG, and MRI data will be acquired within one week before and after intervention. Genetic samples will be collected once. Secondary behavioral outcome measures will be performed again 3 months following tDCS/sham intervention to assess long-term benefits.

Eligibility Criteria:
Inclusion Criteria:

* Between ages 18-85
* At least 12 months post stroke
* Diagnosed with aphasia due to ischemic or hemorrhagic stroke
* English speaking
* Right handed prior to stroke

Exclusion Criteria:

* Nonverbal
* Other neurological diseases/disorders
* Not MRI-compatible (e.g. claustrophobia, metal implants in the head)
Psychobiological Interventions in Pregnancy

This randomized control trial will evaluate whether a physical activity intervention can improve mental health and biologic markers of stress in pregnant people with depressive or anxiety symptoms. The study will enroll participants if they are presenting for prenatal care at Stanford Children's Health Obstetrics Clinic with a singleton gestation.


Eligibility Criteria:
Inclusion Criteria:

* Able to read and write in English or Spanish
* Presenting for a prenatal visit with a viable singleton gestation (no known lethal fetal anomaly or plan for pregnancy termination) between 18 and 20 weeks 0 days
* Any history of depression or anxiety, defined as: 1) documented depression or anxiety in the medical record within the preceding 2 years; 2) baseline EPDS score \>=10 at intake prenatal visit; 3) baseline EPDS anxiety subscale 3A score \>=5

Exclusion Criteria:

* Known allergy to steel or rubber
* Implantable medical device
* Contraindication to physical activity such as a pre-existing cardiovascular condition or arrhythmia
* Plan to relocate and/or deliver at another institution
* Concurrent severe mental illness (diagnosis of bipolar disorder or schizophrenia)
* Known lethal fetal anomaly or nonviable pregnancy
* Baseline \>30 min per week of vigorous physical activity (from Pregnancy Physical Activity Questionnaire, PPAQ)
Examining the Effects of (MiM) Treatment on Emotional and Cognitive Functioning of Residents in Long-term Care

To examine the effects of a music, imagery, and movement (MiM) intervention on emotional and cognitive functioning in residents living in a community-based adult long-term care facility.

Hypothesis 1: Residents who participate in the MiM group will improve in emotional functioning, as compared to residents in the control group.

Hypothesis 2: Residents who participate in the MiM group will improve in cognitive functioning, as compared to residents in the control group.

To implement a community-based integrated music, art and imagery, and movement intervention to improve mood and promote cognitive functioning in older adult residents living in a long-term care facility.

Eligibility Criteria:
Inclusion Criteria:

* Resident in assisted living at long-term care facility with MMSE score above 20

Exclusion Criteria:

* co-morbid psychiatric diagnosis and/or staff clinical evaluation that determines inappropriateness for study inclusion
Visual Training and and Reaction Time in Tennis

Tennis is situational sport in which the result of the game is directly influenced by the interaction with the opponent. In fact, athletes have to respond in a short-time period to change the way of playing by fast analyzing speed, rotation and direction of the tennis ball. Therefore, it is extremely complicated to predict exactly what will happen during games and matches. According to literature goof visual skills, players can receive and process information quickly and can optimize the performance with extreme precision and dexterity. For this reason, visuomotor training aims to improve reaction times, but its efficiency during playing tennis has not yet been investigated. Therefore, the aim of this study is to investigate how this training method could affect the improvement of visuomotor performance in young people between 12 and 18 years old.

Two armed, parallel group, randomized control trial.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥12 years old.
* Playing career of 4 years.

Exclusion Criteria:

* Serious injury in the 6 mouth before the study.
* Subject that already took part to a visual training