cyrilzakka/clinical-trials huggingface dataset:
Postural Based Telerehabilitation in Mechanic Neck Pain

It has been reported that staying in the same posture for a long time causes musculoskeletal system problems, and the use of mobile phones and other electronic devices continuously, especially in the internet age, causes postural problems in many people. Physiotherapy applications including strengthening, stretching, yoga, pain-oriented applications, and behavioral treatments are performed for an ideal posture to regulate postural problems. When the literature is examined, it has been seen that the studies carried out after the Covid 19 pandemic have developed especially in the direction of telerehabilitation, but there is a need for studies showing the effect of exercise applications developed for individuals with mechanical neck pain. This study was conducted to investigate the effect of 12-week telerehabilitation on posture, energy consumption, and performance in individuals with mechanical neck pain.

This cross-sectional study was conducted at the Faculty of Physiotherapy and Rehabilitation, University of Health Sciences. All evaluations were performed in the university physiotherapy laboratories. All of the participants were informed about the study and provided written informed consent. This study was performed in accordance with the 1964 Helsinki declaration, its later amendments.110 people over the age of 18 were included in the study. Posture-oriented exercises were applied online 3 times a week for 12 weeks. Postural measurements, performance, and energy consumption levels were determined for each participant before and after the intervention. Craniovertebral angle and shoulder angle were measured with a smartphone application and muscle shortness was measured with clinical tests among postural measurements. Performance measurement was evaluated with the 6-minute walking test, and energy consumption was evaluated with the Physiological Cost Index. Individuals diagnosed with mechanical neck pain who applied to the university's wellness center for exercise between September 2021 and December 2021 were determined by physiotherapists who are experts in their fields. A cross-sectional selection of 110 individuals met the inclusion criteria. This study was conducted with assessments made before and after posture-based telerehabilitation.

Eligibility Criteria:
Inclusion Criteria:

* Inclusion criteria were being aged 18 years or over,
* Volunteering to take part in the study,
* Being a student of online education,
* without a history of any neurological or orthopedic problem,
* with resting neck pain (as measured by the Visual Analogue Scale) lasting ≤30 days and that is aggravated by movement without extending distal to the shoulders.

Exclusion Criteria:

* The exclusion criteria were neck pain that included inflammatory rheumatological diseases, malignancy, or structural deformity, previous surgery related to the cervical spine,
* Severe referred pain (greater than 7 on a 0-to-10 Visual Analogue Scale-VAS).
Effectivity of Bilateral Transversus Thoracis Muscle Plane Block After Open Heart Surgery

This Study aimed to assess The Effectivity of Bilateral Transversus Thoracis Muscle Plane Block to Reduce Pain and Stress Response After Open Heart Surgery

This is a double blind randomized controlled trial. Thirty-two subject will be recruited with non-probability consecutive sampling method. Subjects who meet all inclusion criteria and do not have exclusion criteria will be asked to sign the informed consent form before included in this study. Subjects will be randomized into two groups. The first group is the treatment group who will get Bilateral Transversus Thoracis Muscle Plane Block after induction of anesthesia and the second group will be the control group who will not get any regional block during surgery. After surgery, time to first morphine dose, total morphine consumption in 24 hours, extubation time, and adverse events will be recorded for both group.

Eligibility Criteria:
Inclusion criteria:

1. Age 19-75 years old
2. Patients who will undergo elective open heart surgery with median sternotomy approach

Exclusion criteria:

1. Patient who does not agree to be included in this study
2. weight \<45kg or \>75 kg
3. Patient with chronic obstructive pulmonary disease
4. Patient with chronic kidney disease who needs regular hemodialysis.
5. Patient with local infection in the injection area for transversus thoracis muscle plane block
6. Patient with chronic pain
7. Patient with history of chronic analgetics drugs usage
8. Patient who is contraindicated for local anesthetics
9. Patient with communication disability
10. Patient with cognitive disorders
11. Patient with severe psychiatrics disorders, such as schizophrenia and bipolar disorder
Coronary Heart Disease Risk in Type 2 Diabetes

The primary objective of the CORDIA study is to use an effective evidence-based self-management intervention (SMI) for type 2 diabetes, with and without a novel test to give a personalised genetic and lifestyle risk of coronary heart disease, to examine their capacity to reduce the risk of coronary heart disease (CHD) and improve diabetes management in primary care patients with type 2 diabetes. The effect of these interventions on clinical, behavioural and psychological outcomes will be investigated.


Eligibility Criteria:
Inclusion Criteria:

* Males and females aged 25-70 years diagnosed with type 2 diabetes
* White, Afro-Caribbean or Asian-Indian ethnicity
* Most previous or baseline HbA1c ≥6.5% or 48 mmol/mol
* Fluency in written and spoken English

Exclusion Criteria:

* Diagnosis of ischemic heart disease, stroke, Transient Ischaemic Attack (TIA) or peripheral vascular disease
* Serious or enduring mental health problems that would prevent the patient from completing the study
* Currently receiving treatment for a life-threatening condition (e.g., cancer) or in the terminal stages of a condition
* Adults who cannot consent for themselves
Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate Measurements in the Intensive Care Unit

The purpose of this study is to see if blood obtained from a vein (smaller blood vessel) can be used instead of blood obtained from an artery (larger blood vessel).


Eligibility Criteria:
Inclusion Criteria:

* Patients admitted to the ICU and requiring both an arterial line and central venous line as prt of their clinical care

Exclusion Criteria:

* Patient did not desire to participate
The Role of Computerized Training in Post-Traumatic Stress Disorder

The purpose of this study is to determine whether a computerized training, "Cognitive Bias Modification" targetting appraisals (CBM-App), can reduce dysfunctional appraisals of trauma in patients with Post-Traumatic Stress Disorder (PTSD), compared to a control condition. Other outcomes measured include symptoms of PTSD and trauma-relevant dysfunctional cognitions. Participants are recruited from inpatients with PTSD admitted to the Clinic for Psychosomatic Medicine and Psychotherapy, LWL University Clinic of Ruhr University of Bochum.


Eligibility Criteria:
Inclusion Criteria:

* Primary diagnosis of Post-Traumatic Stress Disorder according to ICD-10 (F43.1), and DSM-5 (as assessed via Clinician Adminstered PTSD Scale for DSM-5)
* motivated and willing to take part in the study (including questionnaire measures, computer training, filling out questionnaires after discharge)
* aged 18-60 years, male or female
* fluent in German

Exclusion Criteria:

* Substance abuse/ substance dependence currently or in the past six months
* active suicidal thoughts or intentions
* psychotic disorder (past or present)
* learning disability/ intellectual impairment
* red-green colour blindness
Early Breastfeeding Cessation - is It Possible to Prevent?

The purpose of this study is to investigate if a postnatal public health breastfeeding intervention relying on the importance of the psychosocial factors can prolong the period with exclusive breastfeeding duration among mothers who want to breastfeed.

Breastfeeding is a complex learned behaviour and not a capability which comes naturally with motherhood. Different types of professional recommendations have been used to support the new mother in this process.

Randomised studies have shown that postnatal support can influence the breastfeeding duration positively. Various studies has offered different kinds of interventions with home visits and/or telephone calls as the generally used approach, but the proper follow-up on the breastfeeding support in the postnatal period after the mother leaves the hospital is not yet clear.

Eligibility Criteria:
Inclusion Criteria:

* Danish mother, single child, gestational age of not less than 37 full weeks

Exclusion Criteria:

* Mothers with an ethic background other than Danish, preterm delivery,twin birth
Analytical Treatment Interruption in a Patient With HIV Post Allogeneic Stem Cell Transplantation From a CCR5 delta32 Homozygous Donor

Patients who have Human Immunodeficiency Virus-1 (HIV-1) infection, who also had a stem cell transplant may have achieved cure of their HIV infection. Once the patients blood shows no detectable levels of HIV virus in their blood collected from a process called leukapheresis, they will be closely monitored while discontinuing their HIV treatment which is know as antiretroviral therapy or, ART. They will be tested regularly and monitored for up to 52 weeks at which point they may be considered cured of their HIV.

On week -1, a HIV VL and CD4 count will be drawn. If VL remains undetectable, at study week 0, and no other exclusion criteria noted, subject will discontinue ART and enter ATI phase of the study. HIV-1 plasma VL will be monitored every 2 weeks for 52 weeks, then patient returns under the care of their HIV provider. CD4 T cell count will be monitored every 4 weeks.

Depressions symptom check with PHQ-9 check monthly with study visits. Since patients might be cured and at risk of acquiring HIV during the period of treatment interruption, they will be offered Prep on Demand (Truvada) to be used no more than once a month (with notification of study PI when it happens). When Prep on Demand is used, we will ask patient to come in for ART drug level measurement same week.

If patient meets any of the restart ART criteria during the interruption phase, they will discontinue the ATI phase of study and re-start ART and enter the follow up ART phase. If subject maintains undetectable plasma HIV VL (assay quantification threshold 20 copies/mL), they will remain off ART and continue to be monitored until restart criteria are met. If patient meets the restart criteria, they will be followed for 12 months post re-initiation of therapy by their HIV provider. The first month post restart of therapy will require weekly visits, followed by monthly visits thereafter until HIV VL is back \<50 copies/mL. Leukapheresis (per previously approved protocol that patient consented to) will be performed at 6 months and 12 months post ATI if in continued viral remission.

Eligibility Criteria:
Inclusion Criteria:

* Positive HIV testing
* Has undergone a stem cell transplant

Exclusion Criteria:

* under 18 years of age
* unwilling to comply with protocol
Comparison of Low-dose Spiral Breast CT with MRI in Major Indications of MRI for Breast Diagnostics

Comparison between two diagnostic modalities for breast cancer diagnosis. Two different imaging systems are compared to evaluate the performance of the two systems

The diagnostic quality of MRI of the breast has made this method a gold standard in the imaging of senologic lesions. Low-dose dedicated breast CT (BCT) with single photon-detection (nu:view, developed by AB-CT - Advanced Breast-CT GmbH) has emerged as a fully 3D imaging modality that uses ionizing radiation comparable to 2D mammography and has its intended use in helping with diagnosis in diagnostic breast imaging.

The investigation is designed as a prospective non-randomized intra-individual cohort procedure comparison between the imaging platforms, nu:view and MRI. Across 3 hospital-based study sites in two countries, study participants (patients who meet study criteria and have consented) sequentially receive nu:view imaging and, with a delay of up to one week (preferably on the same day), MRI imaging. At both times, patients receive contrast agent. Images generated from breasts are evaluated by three independent radiologists and their scores and interpretations are statistically evaluated. The research aim is to demonstrate non-inferiority of BCT compared with MRI in major indications of MRI for breast diagnostics.

The perceived gain in the study is to generate data on clinical performance of the BCT device nu:view and on the procedure that could be supportive of a tailored use of nu:view in patients with major indications of MRI for breast diagnostics.

Eligibility Criteria:
Inclusion Criteria:

1. Sex: female
2. Age: at least 18 years
3. Inconclusive findings in conventional imaging or preoperative staging or evaluation of therapy response in the neoadjuvant chemotherapy setting or imaging of the breast after breast-conserving therapy or finding the cause of hemorrhagic nipple discharge or prosthesis imaging or screening of women with hereditary or familial increased risk for the development of breast cancer or axillary lymph node metastasis suspected to originate from breast tissue
4. Persons able and willing to understand and sign informed consent form

Exclusion Criteria:

1. Known pregnancy or breastfeeding
2. Presence of BRCA1 or BRCA2 allele
3. Insufficient renal function (MDRD)
4. Dysfunction of the thyroid gland (TSH degradation)
5. Known allergy or intolerance against iodine-containing contrast enhancing agents or MRI contrast enhancing agents
6. Patients with paramagnetic or magnetic material inside the breast, claustrophobia
Effect of Bridge Exercise Performed at Different Knee Angles

Stabilization exercises help increase strength, stability, balance, gait, and endurance through effective abdominal training. Bridge exercise, which is one of the closed kinetic exercises, is one of the most used spinal stabilization exercises. Although that exercise affects on the trunk muscles, it has been stated that it is related to all muscles of the lower extremity.There are some studies, which are examining the activation of the gluteus maximus, quadriceps, rectus abdominus, iliocostalis lumborum, iliocostalis thoracis, and gastrocnemius muscles while exercising the bridge. Although there are some studies investigating the activation of muscles at different knee angles, there is no study in the literature examining the effect of bridge exercise performed at different knee angles on the strength and endurance of lower extremity and trunk muscles. For these reasons, this study aimed to examine the effect of bridging exercises performed at different knee angles on muscle strength and endurance in healthy subjects.

Participants included in the study will randomly divide into 3 different groups by using simple sealed envelope randomization method. Participants in the first group will perform exercise at knee angle was 45⁰ flexion, the participants in the second group will perform to exercise at knee angle 60⁰ flexion and the participants in the third group will perform exercise knee angle at 90⁰ flexion. All participants will include in a bridging exercise program by a blind researcher at predetermined knee angles (45⁰, 60⁰ 90⁰), 3 sets of 15 repetitions per day, 3 days a week for 6 weeks. Evaluations will be done by a blinded researcher 1 week before starting the 6-week exercise program and 1 week after they finished the program. All evaluations will be made by the same physiotherapist by meeting with participants face to face. Inclusion in the research will be on a voluntary basis. As outcome measures, muscle strength assessment and core Endurance Assessment will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

* Being between the ages of 18-27
* Not having any health problems diagnosed in terms of starting the exercise program
* Individuals who do not exercise regularly

Exclusion Criteria:

* Having any identified health problem that would prevent the exercise
* Individuals who exercise regularly
Prolongation of Pain Free Time by the Use of Dexamethasone in Peripheral Nerve Blockade

The main aim of the study is to investigate the proven effect of dexamethsone on the duration of the interscalene block. The investigators try to define optimal dose and volume for ropivacaine, when used together with dexamethsone. The current literature uses often very high volumes of ropivacain when used together with dexamethasone. The investigators try to research the effect of using dexamethsone together with low volume, high concentration ropivacaine for interscalene blockade. The investigators' hypothesis is that dexamethasone has an positive effect on the pain free after used together with ropivacaine at the scalene block.


Eligibility Criteria:
Inclusion Criteria:

* atroscopy of the shoulder
* repair of the RM

Exclusion Criteria:

* patient under 18 years
* patient is fertile
* chronic opiat use more than 30mg oxycodone per day
* operations at the shoulder that involves the bone
* usage of cortisone for more than 2 weeks
* risk greater as asa III
* damage to nerves
* neuropathy at the target arm
The Effects of Intraoperative Dexmedetomidine Infusion on Postoperative Bowel Movement in Patients Undergoing Laparoscopic Gastrectomy

The investigators hypothesized that sympatholytic effect of dexmedetomidine would attenuate the hemodynamic instability and decrease in the splanchnic blood flow caused by pneumoperitoneum during laparoscopic surgery. This study is to investigate the effect of intraoperative dexmedetomidine infusion on postoperative bowel movement in patients undergoing laparoscopic gastrectomy.


Eligibility Criteria:
Inclusion Criteria:

* patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
* gastric cancer patient undergoing laparoscopic gastrectomy

Exclusion Criteria:

* ASA physical status Ⅳ
* bradycardia (\< 60 bpm), arrhythmia
* uncompensated heart failure
* hepatic failure (Child-Pugh score B 이상)
* renal failure (eGFR MDRD \< 60 ml/min/1.73m2)
Safety and Efficacy of LUMIGAN® RC Versus DuoTrav® in Patients Who Require Further Intraocular Pressure (IOP) Reduction

This non-inferiority study will assess safety and efficacy of LUMIGAN® RC (bimatoprost ophthalmic solution 0.01%) versus DuoTrav® (travoprost 0.004%/timolol 0.5% combination ophthalmic solution) in patients previously on Travatan® Z (travoprost ophthalmic solution 0.004%) monotherapy.


Eligibility Criteria:
Inclusion Criteria:

* Open angle glaucoma or ocular hypertension
* Best corrected visual acuity of 20/100 or better in both eyes

Exclusion Criteria:

* Ocular surgery within 3 months, or anticipated ocular surgery within 12 weeks
* Previous treatment with LUMIGAN® RC or DuoTrav®
* History of LASIK, LASEK, RK or PRK in the study eye(s)
* Active ocular inflammation
Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy

This prospective, randomized, controlled, multi-center clinical trial will evaluate the effect and security of reh-acteoside therapy for patients of IgA nephropathy.

Reh-acteoside (general acteoside of rehmanniae leaves) contains more than 10 kinds of bio-active mucopolysaeccharide, among which acteoside is the most effective ingredient, constituting 30 percent. It has been reported that acteoside can reduce mesangium lesion of IgA nephrology-model ddy-mice, mainly by reducing the expressing of TGF-β1, reducing proliferation of mesangial cell and glomerular sclerosis. Research also suggested that conjunctive use of reh-acteoside and benazepril showed better effect on reducing proteinurine than single use of benazepril, with no obvious side effect at the same time. Thus, we start this clinical trial to evaluate the effect and security of reh-acteoside therapy for patients of IgA nephropathy. We set 3 groups: methylprednisolone group, reh-acteoside group and methylprednisolone with reh-acteoside group. After followed-up for 8 weeks, remission of proteinuria and change of renal function will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

Age 14\~70 years, regardless of gender Clinical evaluation and renal biopsy diagnostic for IgA nephropathy. Average urinary protein excretion of 1.0\~3.5g/24h on two successive examinations.

eGFR ≥ 50 ml/min/1.73 m2 Willingness to sign an informed consent (patients under 18 years old need legal guardian to sign).

Exclusion Criteria:

Secondary IgAN such as systemic lupus erythematosus, Henoch-Schonlein purpuric nephritis and hepatitis B -associated nephritis.

Rapidly progressive nephritic syndrome (crescent formation≥50%). Acute renal failure, including rapidly progressive IgAN. Renal biopsy suggests active pathological change (cellular crescent, loop necrosis, micro-thrombosis formation) Current or recent (within 30 days) exposure to steroids or immunosuppressive therapy (CTX、MMF、CsA、FK506).

Recent acute hepatitis (in 2 weeks), chronic active hepatitis (hepatitis B or hepatitis C infection), a rise more than 2.5 folds of current ALT, AST or TBil level.

History of significant gastrointestinal disorders (e.g. severe chronic diarrhea or active peptic ulcer disease).

Any Active systemic infection or history of serious infection within one month. Other major organ system disease (e.g. serious cardiovascular diseases including congestive heart failure , chronic obstructive pulmonary disease, asthma requiring oral steroid treatment or central nervous system diseases).

Active tuberculosis Malignant hypertension that is difficult to be controlled by oral drugs. Known allergy, contraindication or intolerance to the steroids. Pregnancy or breast feeding at the time of entry or unwillingness to comply with measures for contraception.

Malignant tumors Excessive drinking or drug abuse Mental aberrations Current or recent (within 30 days) exposure to any other investigational drugs.