cyrilzakka/clinical-trials huggingface dataset:
Evaluating Endostatin Plus TC Regimen in Secondary Malignant Neoplasm of Liver Using Contrast Enhancement Ultrasonography

Contrast enhancement ultrasonography（CEUS）could be used to evaluate the blood flow perfusion liver cancer. In this clinical trial, CEUS was used to evaluated the changes of blood flow perfusion of Secondary Malignant Neoplasm of Liver after treated with endostatin plus paclitaxel and carboplatin regimen.


Eligibility Criteria:
Inclusion Criteria:

* Histologic diagnosis of nasopharyngeal carcinoma or NSCLC
* With an evaluable secondary malignant neoplasm of Liver, diameter≥2cm
* Without transcatheter arterial chemoembolization (TACE) treatment
* Performance status of 0 to 1 on the Eastern Cooperative Oncology Group (ECOG) Scale.
* Estimated life expectancy of at least 3 months
* Patient compliance and geographic proximity that allow adequate follow-up.
* Adequate organ function including the following: Bone marrow: absolute neutrophil count (ANC) \>or= 1.5x10\^9/L, platelets \>or= 100x10\^9/L, hemoglobin \>or= 9g/dL. Hepatic: bilirubin \<1.5 x ULN, alkaline phosphatase, aspartate transaminase (AST) and alanine transaminase (ALT) \< 2.5 x ULN (alkaline phosphatase, AST, ALT \< 5 x ULN is acceptable if liver has tumor involvement). Renal: calculated creatinine clearance \> 45 ml/min.
* Men or women of at least 18 years of age.
* Signed informed consent from patient.

Exclusion Criteria:

* Women who are pregnant or in lactation
* Systemic treatment for another cancer within the year prior to study entry
* Known hypersensitivity to any of the study drugs or to drugs with similar chemical structures
* Use of investigational agents within 28 days of the Baseline visit, or participating simultaneously in any other clinical studies
* Severe co-morbidity of any type that may interfere with assessment of the patient for the study
Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty)

Different techniques of deep anterior lamellar keratoplasty (DALK) have been introduced to create a uniform recipient bed, thereby reducing complications, such as interface irregularity and opacification encountered with conventional lamellar keratoplasty. The big-bubble technique provides a planned, safe, quick and consistent baring of Descemet membrane (DM) by injection of air deep into the stroma. Nevertheless, this technique has a long learning curve with a low success rate of big-bubble formation and a high rate of DM perforation when performed by surgeons in training. Different modifications to the original technique using intraoperative instruments such as corneal pachymetry, anterior segment optical coherence tomography (OCT), and femtosecond laser, have been used to increase the chances of achieving a successful DM detachment from the deep stroma by air injection. Even with these innovations, the rate of successful big-bubble formation did not reach 100%. Recently, the investigators described a modification to the original big-bubble DALK in which a 27-gauge needle was inserted into the stroma peripherally from the trephination site towards the limbus. The investigators found that air injection peripheral to the trephination can effectively and reproducibly separate the corneal stroma from the Descemet membrane (DM). This study was aimed to compare the success rate and complications of big-bubble DALK using central versus peripheral air injection performed by senior cornea fellows under the supervision of an experienced faculty member in an academic hospital.


Eligibility Criteria:
Inclusion Criteria:

* Patients with moderate (48 D \< mean keratometry \< 55 D) to advanced (mean keratometry ≥ 55 D or immeasurable keratometry) keratoconus were enrolled.

Exclusion Criteria:

* History of ocular surgery, concomitant ocular pathologies, such as vernal keratoconjunctivitis, cataract, glaucoma, and retinal abnormalities.
Impact of Training Dental Students for an AI-Based Platform

The emergence of artificial intelligence (AI) and specifically deep learning (DL) have shown great potentials in finding radiographic features and treatment planning in the field of cariology and endodontics . A growing body of literature suggests that DL models might assist dental practitioners in detecting radiographical features such as carious lesions, periapical lesions, as well as predicting the risk of pulp exposure when doing caries excavation therapy. Although, current literature lacks sufficient research on the effect of sufficient training of dental practitioners for using AI-based platforms. This prospective randomized controlled trial aims to assess the performance of students when using an AI-based platform for pulp exposure prediction with and without sufficient preprocedural training. The hypothesis is that participants performance at group with sufficient training is similar to the group without sufficient training.


Eligibility Criteria:
Inclusion Criteria:

* perhaps 4th year and 5th year dental students at the university of Copenhagen who are willing to participate voluntarily and have signed the consent letter.
* Limited or no previous knowledge and experience about AI

Exclusion Criteria:

* None
The Neural Correlates of Cannabis Use

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using \[11-C\]OMAR PET imaging and electroencephalography.

Eligibility Criteria:
Inclusion Criteria: Cannabis Dependent Subjects

* Current cannabis consumption
* Willing to abstain from cannabis use for four weeks

Inclusion Criteria for Healthy Controls

* No current cannabis consumption

Exclusion Criteria:

* MRI metal exclusions and claustrophobia
* Education completed is less than 12 years
The Effects of Cold Water Immersion With Different Dosages (Duration and Temperature Variations) on Heart Rate Variability Post-exercise Recovery

The aim of the present study was to investigate the effects of cold water immersion (CWI) during post-exercise recovery with different durations and temperatures on heart rate variability (HRV) indices. 100 participants performed a protocol of jumps and a Wingate test, and immediately afterwards were immersed in cold water, according to the characteristics of each group (CG: control; G1: 5' at 9±1°C; G2: 5' at 14±1°C; G3: 15' at 9±1°C; G4: 15' at 14±1°C). Analyses were performed at baseline, during the recuperative technique (TRec) by CWI and 20, 30, 40, 50 and 60 minutes post-exercise. The HRV indices average of all RR intervals in each analysis period (Mean RR), standard deviation of normal R-R intervals (SDNN), square root of the mean of the sum of the squares of differences between adjacent R-R intervals (RMSSD), spectral components of very low frequency (VLF), low frequency (LF) and high frequency (HF), scatter of points perpendicular to the line of identity of the Poincaré Plot (SD1) and scatter points along the line of identity (SD2) were assessed. Comparisons between groups and moments were performed using the technique of analysis of variance for repeated measures in two scheme factors. A significance level of p\<0.05 was considered.


Eligibility Criteria:
Inclusion Criteria:

* male sex
* healthy
* aged between 18 and 30 years
* classified as physically active through the International Physical Activity Questionnaire

Exclusion Criteria:

* smokers
* alcoholics
* use drugs that influenced cardiac autonomic activity
* cardiovascular, metabolic or endocrine diseases.
ACRYSOF® ReSTOR® Aspheric +3.0 D Add Power Intraocular Lens (IOL)

Randomized, parallel group, subject masked, multi-center six (6) month follow-up study comparing ACRYSOF® ReSTOR® Aspheric +3.0 D Add Power IOL Model SN6AD1 implanted in both eyes to ACRYSOF® ReSTOR® Aspheric +4.0 D Add Power IOL Model SN6AD3 implanted in both eyes.


Eligibility Criteria:
Inclusion:

* Adults, 21 years of age or older at the time of surgery, of either gender or any race, diagnosed with bilateral cataracts
* Calculated lens power is within the available range
* Willing and able to complete all required postoperative visits
* Planned cataract removal by phacoemulsification and/or liquifacture
* Potential postoperative visual acuity of 0.2 logMAR or better in study eyes
* Preoperative astigmatism of 1.0 Diopter (D) or less, measured by keratometry in study eyes
* Clear intraocular media other than cataract in study eyes
* Able to comprehend and sign a statement of informed consent
* Preoperative Best Corrected Distance Visual Acuity (BCDVA) worse than 0.2 logMAR, or if BCDVA is equal to or better than 0.2 logMAR, BCDVA with a Brightness Acuity Tester (BAT) on "Medium" setting must be worse than 0.2 logMAR

Exclusion:

* Significant irregular corneal aberration as demonstrated by corneal topography
* Subjects with diagnosed degenerative visual disorders (e.g., macular degeneration or other retinal disorders) that are predicted to cause future acuity losses to a level worse than 0.2 logMAR
* Subjects who may reasonably be expected to require laser treatments at any time
* Previous corneal refractive surgery
* Amblyopia
* Clinically severe corneal dystrophy (e.g., epithelial, stromal, or endothelial dystrophy)
* Diabetic retinopathy
* Extremely shallow anterior chamber, not due to swollen cataract
* Microphthalmos
* Previous retinal detachment
* Previous corneal transplant
* Recurrent severe anterior or posterior segment inflammation of unknown etiology
* Rubella or traumatic cataract
* Iris neovascularization
* Glaucoma (uncontrolled or controlled with medication)
* Aniridia
* Optic nerve atrophy
* Pregnancy
* Current or previous usage of an alpha-1-selective adrenoceptor blocking agent or an antagonist of alpha 1A adrenoceptor (e.g.Flomax® (tamsulosin HCL), Hytrin®, or Cardura®)
* Any subject currently participating in another investigational drug or device study that may confound the results of this investigation
Aldosterone in Diabetic Nephropathy

The purpose of this study is to determine whether spironolactone are effective in the reduction of albuminuria and diastolic disfunction of subjects with diabetic nephropathy.


Eligibility Criteria:
Inclusion Criteria:

* Diabetic subjects with maximum ten years after diagnostic
* Diabetic nephropathy with albuminuria
* Normal renal function
* Diastolic disfunction
* Taking a IECA or ARA drug family previously

Exclusion Criteria:

* Diabetics subjects with macroangiopathy
* Acute coronary syndrome in the three months before
* Hyperkalemia \> 5.5 mEq/L
* Pregnancy
Hystrolaparoscopic Findings in Infertile Women with Previous Uterine Surgery

1. to determine the rate and pattern of abnormal laparoscopic finding among the infertile women with history of previous uterine surgery.
2. To detemine the rate and pattern of abnormal hysteroscopic finding among infertile women with with history of previous uterine sergery
3. to evaluate the value of doing combined laparoscopy and hysteroscopy in infertile women with with history of previous uterine surgery.
4. To determine possible risk factors of pelvic adhesions detected during laparoscopy.
5. To determine possible risk factors causing cs niche.

nfertility(1), which refers to the inability of a couple to conceive after one year of regular unprotected sexual intercourse, is the commonest indication for gynacological consultation. primary infertility - where someone who's never conceived a child in the past. secondary infertility(2) - where someone has had 1 or more pregnancies in the past, but is having difficulty conceiving again.there are many causes for infertility. (3)uterine causes as uterine fibroids or malformations.tubal factors as tuboperitoneal adhesions,unilateral or bilateral proximal occlusion unilateral or bilateral hydrosalpinx or pyosalpinx.Ovarian factors ovarian cyst,polycystic ovaries.pelvic causes as adhesions ,endometriosis and miscellaneous. laparoscopy can be used as the gold standard diagnostic tool which allows direct visualization of all pelvic organs. It also helps in detailed assessment of fallopian tubes. The advantage behind using laparoscopy is that the treatment of certain conditions such as tubal obstruction, endometriosis, and pelvic adhesions can be done at the same time during diagnosis. If needed, laparoscopic chromopertubation can also be done for tubal patency during the same sitting. (4)Hysteroscopy is the direct visualization of the uterine cavity using an endoscope. Uterine cavity evaluation is very much needed to do achieve total infertility workup. Uterine abnormalities are present among 10-15% of couples who seek treatment of infertility. For evaluation of endometrial factors,(5) hysteroscopy considered to be a gold standard. Diagnostic h hysteroscopy can detect uterine anomalies which remain undetected in USG and other routine investigations.

Many studies reported the occurrence of pelvic adhesions following cesarean section with its related consequences.

pelvic adhesions may affect both reproductive system anatomy and function, causing various associated conditions. Pelvic adhesions may cause secondary infertility, which might be due to dyspareunia, disturbing tubo-ovarian relationship, or disturbing peristaltic movement of fallopian tube.

Eligibility Criteria:
Inclusion Criteria:

* All women between20 to 35 yrs old with secondary infertiliy for 2 years
* Women with previous uterine surgery

Exclusion Criteria:

* Female with major medical illness(Uncontrolled daibetes, cardiac diseases, uncontrolled thyroid disorders)
* Abnormal semen parameter of the husband.
The Use of Extended Platelet Rich Fibrin in Lateral Sinus Augmentation

thirty implants will be inserted in patients seeking implantation of their lost posterior maxillary teeth (premolar and molars) with limited bone height below the floor of the maxillary sinus, secondary to sinus pneumatization. The patients will be selected from those attending the outpatient clinic of the Oral \& Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University.

1. Clinical Evaluation

   • Implant stability
2. Radiographic Evaluation Vertical bone gain (VBG)


Eligibility Criteria:
Inclusion Criteria:

* Patent ostium of maxillary sinus.
* Patient with missing one or more posterior maxillary teeth.
* Residual bone height of 3-6 mm, measured from the crest of alveolar ridge to the floor of the maxillary sinus at the planned implant site.
* A ridge width at the site of implantation of \<5mm.
* Platelets of normal range.
* Good oral hygiene.
* Patients in the age frame between 20 years and 60 years old.
* No gender preface in selection of the patients.
* A minimum crown height space of 8 mm.

Exclusion Criteria:

* Active sinusitis, cyst, tumors or root tips at the planned surgical site.
* Patients with systemic diseases that contra-indicate the surgical procedure such as uncontrolled diabetes mellitus, bleeding disorders, serious osseous disorders, and mental disorders.
* Heavy smoking and alcoholism.
* Parafunctional habits such as bruxism and clenching.
* Signs of acute infection or pus discharge.
* Disturbed occlusion.
Study of the Expression of Endoplasmic Reticulum Stress During Extracorporeal Circulation in Humans

The links between systemic inflammation, endothelial dysfunction and endoplasmic reticulum (ER) stress in pre-clinical models make it an interesting potential therapeutic target, but there are no data describing SRE during severe inflammation in humans .

For an approach to the study of SRE in humans in a situation of systemic inflammation, the analysis of patients benefiting from an extra-corporeal circulation for a programmed cardiac surgery would allow a study under well described conditions of inflammation, standardized, with the possibility for each patient to be his own witness. Compared to a situation of secondary inflammation (sepsis, acute pancreatitis, trauma ...) the analysis of the patients under CEC allows more precise description of the kinetics of the activation of the SRE because the beginning of the inflammatory mechanism is known with precision.


Eligibility Criteria:
Inclusion Criteria:

* Major patient (age ≥ 18 years)
* Patient undergoing cardiac surgery under extracorporeal circulation (duration of planned CEC \> 1h)
* Informed person, having read and signed his consent preoperatively no later than the day before the procedure.
* Person affiliated with a social security scheme
* Effective contraception in women of childbearing potential. For menopausal women, the diagnosis of menopause will be based on the gynecological history of the patient (age\> 50 years + amenorrhea for more than 12 months).

Exclusion Criteria:

* Patient with urgent cardiac surgery
* Patient with cardiac surgery without extracorporeal circulation
* Patient with surgery under "mini-CEC"
* Patient with simple aortic valve replacement or single / double coronary artery bypass (CEC duration typically \<1h)
* Patient with chronic autoimmune inflammatory disease, eg lupus, rheumatoid arthritis, inflammatory bowel disease ...
* Patient with progressive neoplastic disease
* Patient with underlying heart disease with left ventricular ejection fraction \<30%
* Pregnant or lactating woman
* Person deprived of liberty by an administrative or judicial decision or protected major subject (under tutorship or curatorship)
* Patient participating in another interventional clinical trial
IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea

Patients presented with dysmenorrhea composed the study population. One gram paracetamol and 50 mg dexketoprofen in 100 ml saline with a rapid infusion were compared in ceasing dysmenorrhea in emergency department.

Patients over 18 years old who presented with dysmenorrhea composed the study population. Patients received pain killer within the last six hours, physical findings consistent with peritoneal irritation, allergy to the study drugs, renal or liver failure, drug addiction, pregnancy or woman with lactation and denied to give inform consent were the exclusion criteria. The pain of the study patients are measured with visual analogue scale at baseline, 15th and 30th minutes. At the end of the 30 minutes, rescue drug need is also recorded.

Eligibility Criteria:
Inclusion Criteria:

* Patients with dysmenorrhea
* Patients over 18 years old

Exclusion Criteria:

* denied to give inform consent
* Renal or liver failure
* Allergy to the study drugs
* Receiving pain killer within the last 6 hours.
* Physical examination findings consistent with peritoneal irritation
* Pregnancy or patients with lactation
* Drug addiction
Short Atrioventricular Delay Pacing

We intend to examine the effects of temporary elevation of atrial wall stress by shortening of the atrioventricular delay in patients with dual-chamber pacemakers.


Eligibility Criteria:
Inclusion Criteria:

* Chronically (i.e. implanted for at least six months) dual-chamber pacemaker
* Stable cardiac status (i.e. no hospitalizations or cardiac medication changes within 3 months)
* Ability to provide informed consent

Exclusion Criteria:

* Age \<18 years or \>80 years
* Pregnancy (if pregnancy is suspected, a urine pregnancy test will be performed)
* Recent (within 12 months) left ventricular ejection fraction \<50%
* Significant valvular heart disease (mitral regurgitation of greater than mild severity, any degree of mitral stenosis, aortic stenosis or insufficiency of greater than mild severity)
* Prior coronary artery bypass graft or valve surgery, recent (i.e. within 3 months) acute coronary syndrome or percutaneous coronary intervention, or chronic stable angina
* History of clinically important atrial or ventricular tachyarrhythmias, defined as complex ventricular ectopy (i.e. couplets, triplets, or ventricular tachycardia), AF, atrial tachycardia, or other supraventricular tachycardias not cured with prior ablative therapy).
* Significant chronic systemic inflammatory or neoplastic disease
* Chronic renal or hepatic insufficiency. Renal insufficiency will be defined as a creatinine clearance of less than 20 cc/min. Evidence of hepatic insufficiency will consist of abnormal synthetic function (INR \>1.4 without oral anticoagulant use, albumin \< 3.0 mg/dL) or abnormal clearance function (total bilirubin \>2.0).
* Uncorrected thyroid abnormalities
Diabetes Mellitus and HIV Study in Mwanza

Emerging evidence from high-income countries suggests that diabetes mellitus is become a major health problem among HIV-infected patients. However, due to differences in social, environmental, and genetic factors data from high-income countries can not be extrapolated directly to low-income countries. This study investigates HIV, ART, inflammation, and body composition changes as risk factors for diabetes mellitus among HIV-infected patients in Tanzania.

Access to antiretroviral therapy (ART) is increasing rapidly in low-income countries and HIV-infected patients initiate ART much earlier. As a result, these patients have prolonged life spans and, hence, longer HIV and ART exposure. Emerging data from developed countries suggest that HIV-infected patients have a higher risk than HIV-uninfected people of developing diabetes mellitus (DM) and other non-communicable diseases. The excess diabetes risk is probably related to multiple factors including HIV-associated inflammation, the use of some antiretroviral therapy (ART) regimens, and body composition changes associated with HIV and ART. As a result, HIV-infected populations may develop DM at a younger age and may have a higher mortality if management is not optimal as may be the case in resource-limited countries of Sub-Saharan Africa (SSA).

Most of the data to-date on HIV and DM are from high-income countries, and data in SSA are few and inconsistent. Because of differences in genetic composition as well as environmental factors including high burden of infectious diseases in resource-limited settings, data from high-income countries cannot be extrapolated and reliably used to improve quality of DM care among HIV patients in SSA. The objective of this study is to investigate if HIV, ART, and body composition changes occurring during ART use are associated with higher risk of DM as well as other risk factors for cardiovascular diseases in Tanzanian patients, and examine if HIV increases the risk of DM associated complications. This study is funded by the Danish Ministry of Foreign Affairs from 2016 to 2021.

Eligibility Criteria:
Inclusion Criteria:

* For existing cohorts, patients should come from NUT-TB or NUSTART Cohorts
* For New HIV cohort, patients should be HIV positive ART naive, HIV negative participants will be come from the same neighborhood as newly recruited HIV positive patients
* Age will be 18 years and above
* Mwanza region residency
* Not planning to relocate outside Mwanza within the study period

Exclusion Criteria:

* Very severe illness