cyrilzakka/clinical-trials huggingface dataset:
Abbreviated MRI for HCC Surveillance

This study aims to investigate the clinical feasibility of abbreviated liver MRI for HCC surveillance in a high-risk group.


Eligibility Criteria:
Inclusion Criteria:

* high risk of HCC development (chronic hepatitis B, chronic hepatitis C, liver cirrhosis)
* no history of HCC
* on surveillance of HCC using ultrasonography
* sign informed consent

Exclusion Criteria:

* history of HCC
* congestive hepatopathy
* iron deposition
* any absolute or relative contra-indication of contrast-enhanced MRI
Autonomic Nervous System Activity and Oculocardiac Reflex.

Pulling the eyeball during ophthalmic surgery provokes decrease in heart rate. This phenomenon is called oculocardiac reflex. In some patients asystole may occur. Other cardiac features of this reflex include hypotension, dysrhythmias, atrioventricular block. These cardiovascular disturbances may lead to decreased perfusion and ischemia of vital organs. Patients with existing cardiovascular disease are in risk of complications. Cardiovascular system is mainly innervated with autonomic nervous system (ANS). Sympathetic/parasympathetic activity may be determined by Heart Rate Variability (HRV). HRV analysis based on short 5 minutes electrocardiography has been found useful for prediction of hypotension and bradycardia during induction of general anaesthesia and during spinal block. The aim of this study is to verify whether it is possible to predict oculocardiac reflex with the use of HRV analysis for ANS activity assessment, measured prior to the ophthalmic surgery.


Eligibility Criteria:
Inclusion Criteria:

* planned surgery
* over 18 years of age
* surgery under general anaesthesia

Exclusion Criteria:

* urgent surgery
* under 18 years of age and over 65
* patients with generalised, nontreated disease
* patients receiving beta blockers or calcium channel blocker
* diabetic patients
* patients operated under peri or retrobulbar anaesthesia
An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial

The study compares two widely used treatments in closing the wound after open carpal tunnel release surgery: absorbable and non-absorbable sutures. It is conducted as a randomized controlled trial, where the participants are divided into two research groups. The visual outcome of the scar will be evaluated a year after the surgery.

Absorbable sutures are more cost efficient and eliminate the need for suture removal both reducing costs and abolishing suture removal pain. We will study the difference in the visual outcome between the two groups. Based on former study the primary hypothesis is that there is no difference between the groups. The patients will evaluate their scars on a VAS-scale one year after the surgery. Secondarily we will focus on pain caused by the two sutures and take the suture removal pain into consideration. We expect therefore the non-absorbable suture to cause more pain in total. The evaluation will happen 2 weeks after the surgery by the patients.

Eligibility Criteria:
Inclusion Criteria

* carpal tunnel syndrome diagnosed with electro near my-graphs
* symptoms typical of carpal tunnel syndrome
* referral to carpal tunnel release
* informed consent signed
* the ability to receive the virtual questionnaire via email and answer it
* the ability to understand and answer the Finnish questionnaires

Exclusion Criteria

* repeat surgery
* known allergy to suture materials
* ongoing systemic steroid treatment
* ongoing chemotherapy
* ongoing immunomodulatory treatment
* past hypertrophic or keloid scars or other severe disturbances in wound healing
* age under 18, pregnancy or breastfeeding
Maternal Diabetes in Newborns With Hearing Loss

This study aims to investigate the presence and characteristics of maternal diabetes as a risk factor in newborns with hearing loss.

Hearing loss is one of the most common congenital anomalies among newborns. The newborn hearing screening program is important for early diagnosis in newborns with hearing loss.Gestational diabetes, on the other hand, is a metabolic disease that occurs during pregnancy and can cause complications as in other diabetes mellitus patients.

Despite our knowledge of major complications, the effect of the hyperglycemic intrauterine environment on hearing outcomes has not been adequately studied. The inner ear does not store energy, so it has a particularly high sensitivity to altered blood sugar and insulin. Altered inner ear metabolism leads to auditory and balance disorders.

There is no study in the literature comparing uncomplicated gestational diabetes and pregestational diabetes as a prenatal complication that poses a risk of hearing loss.


Eligibility Criteria:
Inclusion Criteria:

* POSTNATAL AGE BETWEEN 0-28 DAYS
* BIRTH WEIGHT ≥2000GR
* TO HAVE TESTED ON THE NEWBORN HEARING SCREENING UNIT AT ANKARA CITY HOSPITAL

Exclusion Criteria:

* PRETERMS
* CRANIOFACIAL ANOMALIES
* INTRAUTERINE INFECTIONS
* BIRTH WEIGHT \<2000 GR
Strong Hearts: A Remote, App-Enabled, Exercise Program for Patients With Congenital Heart Disease (Strong Hearts App)

The overall goal of this program is to create a remote, mobile application enabled exercise program for patients with Congenital Heart Disease (CHD). Pilot trials will consist of a remote exercise program with app-embedded exercise modules designed to promote and encourage safe and healthy exercise habits across a range of CHD anatomies. This app-enabled program will allow for real time data collection integrating wearable devices, as well as compliance and safety monitoring to enhance research capabilities. The app-enabled program will be versatile and may be applied in the future to patients with non-cardiac conditions.


Eligibility Criteria:
Inclusion Criteria:

* Repaired or unrepaired Congenital Heart Disease (CHD)
* Between ages 10 and 50, inclusive, at time of consent
* Android or Apple smartphone that meets the operating systems below with the ability to download applications from either Google Play or the Apple store

  * Android: 6.0 or higher
  * Apple: iPhone Operating System (iOS) 13 or higher

Exclusion Criteria:

* Physical or mental disabilities preventing exercise participation
* Uncontrolled systemic hypertension (symptomatic or greater than Stage 2 hypertension while on therapy)
* Poorly controlled arrhythmia
* Clinically unstable heart failure
* Known pregnancy at the time of enrollment
Community Pharmacists Behaviour During Covid-19

During the COVID-19 pandemic, governments issued movement restrictions and placed areas into quarantine to reduce the spread of the disease.Community pharmacists and their teams are a vital healthcare provider during the outbreak; they remain on the frontline of public health by serving as direct points of access for their patients. The retail pharmacists should provide public community, costumers and patients with right and trusted information about covid-19. They also should have role in awareness spreading regarding personnel safety and hygiene

The survey will enroll as many community pharmacists as possible in the survey portion of the study - The number of participates have no limitations, at least 50 participants.

The survey will be enrolled in online google form, face to face interview \& semi-structured telephone interviews if possible.

The research procedures:

1. An online survey link will include questions regarding the impact of role and behavior of retail pharmacists during covid-19 outbreak.
2. Face to face and semi-structured interviews if possible: For those pharmacists who state that they would like to participate in an interview, a random sample will be contacted.

Inclusion Criteria:

1. Post graduated pharmacist.
2. Community pharmacists.

Exclusion Criteria:

1. under graduated students.
2. not pharmacist.

Eligibility Criteria:
Inclusion Criteria:

* Post graduated pharmacist. Community pharmacists.

Exclusion Criteria:

* under graduated students. not pharmacist.
A Study of Rivaroxaban for Early Discharge of Low Risk Pulmonary Embolism From the Emergency Department

The purpose of the study is to evaluate that low risk Pulmonary Embolism (PE) participants who are discharged from the Emergency Department (ED) to the home environment and treated with rivaroxaban as outpatients have fewer total days in the hospital for bleeding and/or venous thromboembolism (VTE) events through Day 30 compared to participants who are treated with initial hospitalization and standard-of-care.

This is a randomized (study medication is assigned by chance), open-label (all people know the identity of the intervention), parallel-group, multicenter (study conducted at multiple sites) study to evaluate that low risk PE participants who are discharged from the ED and treated with rivaroxaban compared to participants who are treated with initial hospitalization and standard-of-care. The study consists of a Screening and Randomization Period, followed by a 90-day open-label treatment period, and an end of study/early withdrawal (EOS) visit. The duration of study participation for each participant is approximately 3 months. The participants will be randomized in a 1:1 ratio to one of two treatments. Safety will be monitored during the study.

Eligibility Criteria:
Inclusion Criteria:

* Have confirmed acute symptomatic Pulmonary Embolism (PE) with or without symptomatic deep vein thrombosis (DVT)
* A PE participant diagnosed in the Emergency Department (ED) who is deemed to be at low risk of clinical deterioration as determined by the Hestia criteria
* Have no contraindications to and be able to complete randomized treatment and all study assessments
* Have a life expectancy of at least 6 months
* Must be willing and able to adhere to the prohibitions and restrictions specified in this protocol

Exclusion Criteria:

* Having received any Combined P-gp (P-glycoprotein) and strong CYP3A4 (Cytochrome P450) inhibitors (such as but not limited to ketoconazole, telithromycin or protease inhibitors) use within 4 days before randomization, or planned use during the study. Itraconazole use within 7 days before randomization or planned use during the study
* Having received any Combined P-gp and strong CYP3A4 inducers (such as but not limited to rifampin/rifampicin, rifabutin, rifapentine, phenytoin, phenobarbital, carbamazepine, or St. John's Wort) use within 2 weeks before randomization or planned use during the study
* Who Has contraindications to the use of any anticoagulant therapy (example, bleeding diathesis, history of gastrointestinal bleeding within 1 year or coagulopathy documented at Screening)
* Who Has known allergies, hypersensitivity, or intolerance to rivaroxaban or its excipients
* Woman who is pregnant, or breast-feeding, or planning to become pregnant
Screening, Treatment, and Eradication of Hep C

The aim of this study is to assess the HCV screening rate in Arizona by identification of potential HCV patients/subjects through different methods of communication - text message, email, social media, radio, newspaper ads, and flyers.

The study will focus on various methods of communication to reach the population of Arizona from the most prevalent counties to lowest prevalence. The study is organized into phases focusing on the various communication methods beginning with direct communication through mass text messages and mass emails followed by indirect communication through social media (YouTube, Facebook), newspaper, radio, Alcoholics Anonymous meetings, Narcotics Anonymous meetings, and homeless shelters. Each phase will consist of four cycles of a monthly intervention period in which communication will be active and a two-month gap that will be used to assess effectiveness of the communication method. Subjects will receive information on HCV, contact information for the study coordinator at the Liver Institute PLLC to address questions or concerns, and a code that will allow them to receive a free HCV screening test at their local Sonora Quest Lab. This code can be used at the time of receipt or a few months later, whenever the subject is ready for testing. This timeline allows to enhance subject compliance. The results from Sonora Quest Lab will be transmitted to the study coordinator at the Liver Institute PLLC and depending on the subject's insurance status will link the subject to a treatment center. Ideally it will be their primary care physician but if the subject does not have one then it will be the closest treatment center. Alternatively, the Liver Institute PLLC is also equipped to provide telemedicine appointments to evaluate the subject and provide treatment depending on insurance status. Those that are uninsured will be provided with available options for treatment. All subjects will receive information on the disease to reduce transmission and encourage friends/family to get tested. This study will function on a version of the test-and-treat approach to help reduce the spread of HCV in the Arizona population.

Eligibility Criteria:
Inclusion Criteria:

* Subjects must sign the consent to screen and take part in the study.
* Subjects must be at least 15 years of age

Exclusion Criteria:

* Patients will only be enrolled once
* Patients who do not meet the inclusion criteria
* Patients with a current HCV diagnosis
* Patients who underwent a liver transplant
External Versus Internal Feedback in Patients With Chronic Ankle Instability

Although altered biomechanics has been well documented as an impairment associated with chronic ankle instability (CAI), effective interventions targeting biomechanics with long-term outcomes measuring patient-reported outcomes (PROs) are absent. Evidence suggests that external focus of attention (ExFOCUS), internal focus of attention (InFOCUS) feedback, and auditory feedback during movement training can alter biomechanics in other patient populations, with ExFOCUS and auditory enhancing retention of learned biomechanics. Therefore, this randomized controlled trial will determine if a 4-week (12 session) impairment-based rehabilitation program that includes feedback (ExFOCUS or InFOCUS or Auditory) can (1) decrease ankle inversion kinematics and lateral plantar pressure during walking and (2) improve self-reported function.


Eligibility Criteria:
Inclusion Criteria:

* Characterized as having chronic ankle instability (CAI) by reporting a history of recurrent ankle sprains, with the first sprain occurring longer than 12 months ago. Participants will have lingering symptoms, and disability, but have not actively sought treatment for their CAI.
* All participants will be physically active: Participating in some form of physical activity for at least 20 min per day, three times per week.

Exclusion Criteria:

* Neurological or vestibular disorders affecting balance
* Currently seeking medical care for CAI
* History of ankle surgery
* History of ankle sprain within the past 6 weeks
* History of other musculoskeletal injuries within the past 6 weeks
* Current/previous self-reported disability due to lower extremity pathology that may adversely affect neuromuscular function
Pre-conception Interventions to Reduce Blood Pressure Before Pregnancy

The study proposes to evaluate the feasibility of a preconception intervention comprising two proven interventions for reducing blood pressure; Beetroot juice; a source of dietary nitrate which reduces BP by 8/4mmHg after 4 weeks(6); Personalised resistance and endurance exercise programme (as per CMO recommendations) which reduces BP by \~10/5mm Hg over 8-12 weeks (7).

A feasibility study will be conducted for a randomised, controlled trial of preconception interventions.

The study will advertise using posters, social media and on departmental emails at Imperial College Healthcare NHS Trust or Imperial College for women aged 18-45 planning a pregnancy at any time in the future.

The study will randomise women to 1 of 4 arms Arm 1: Exercise intervention for weeks 1-12 Arm 2: Beetroot juice for weeks 1-12 Arm 3. Exercise and Beetroot juice for weeks 1-12 Arm 4: Control group

Women will be provided with daily Beetroot juice shots (as per study arm), membership to an Everybody Active centre close to their home, personal training sessions to tailor an exercise program to them (2 initial sessions then monthly), a wearable to track their physical activity and a home BP monitor.

Eligibility Criteria:
Inclusion Criteria:

* Aged 18-45
* considering pregnancy at some time in the future
* no health contra-indications to moderate-vigorous exercise
* employed by ICHT NHS Trust or Imperial College.

Exclusion Criteria:

* Currently pregnant
* planning pregnancy during the study period, or becoming pregnant during the study period.
The Effect of Mindfulness Training on Premenstrual Syndrome Symptoms and Quality of Life

Premenstrual syndrome (PMS) is an important health problem that negatively affects women's quality of life by reducing their daily activities, sleep quality, cognitive functioning, interpersonal relationships, academic performance, work and school attendance. Studies show that PMS is associated with unhealthy life behaviors and that PMS can be reduced through the development of healthy life behaviors. Midwives can benefit from mindfulness-based programs while providing quality health care services to develop a healthy lifestyle in the prevention and treatment of PMS in women. In the literature, there is no study examining the effectiveness of mindfulness-based healthy life behaviors training on PMS. To the best of our knowledge, our study is the first study to examine the effect of a mindfulness-based healthy life behaviors training program on premenstrual syndrome symptoms and quality of life.


Eligibility Criteria:
Inclusion Criteria:

Being a student at Gülhane Faculty of Health Sciences, University of Health Sciences Regular menstruation Experiencing moderate PMS Agreeing to participate in the study

Exclusion Criteria:

Being a student in the Department of Midwifery Having a psychiatric diagnosis or gynecological disease Kontraseptif medication use Having a health problem Receiving treatment for PMS
Follow-up of Endovascular Aneurysm Treatment - The FEAT Trial

After endovascular abdominal aortic aneurysm repair, life-long follow-up is needed to monitor the effectiveness of exclusion of the aneurysm sac from blood flow. For this reason, aneurysm diameter and the presence of endoleaks is evaluated with CT angiography yearly after Endovascular Aneurysm Repair (EVAR).

The aim of this study is to investigate the value of MRA examinations for the follow-up of these patients. The advantages of MRA with respect to CTA are no use of ionizing radiation, use of less nephrotoxic contrast agents.

The FEAT trial (Follow-up of Endovascular Aneurysm Treatment) is designed as a prospective, single-center, follow-up study. 100 Patients will be enrolled in this study. These patients will undergo additional MRA-examinations the day before EVAR, the day after EVAR, 6 months and 1 year after EVAR. These patients also participate in the conventional CTA follow-up scheme which comprises a pre- and post-operative CTA and a CTA yearly thereafter. Coagulation parameters in the blood will be measured before and 1 year after EVAR.

Eligibility Criteria:
Inclusion Criteria:

* Patient is planned for endovascular abdominal aortic aneurysm repair

Exclusion Criteria:

* contraindication for MRI examination

  * claustrophobia
  * pacemaker
  * other non-MRI compatible implants
Influence of Pilates-based Exercises on Postural Balance

The study of the behavior of the mechanisms of body balance with a workout based on the Pilates method can facilitate the development of more accurate rehabilitation approaches. However, there is still little scientific information on its effects on the locomotor system and it's necessary to search for new methods to evaluate its strategies more specifically. Thus, this study aims to determine whether an exercise program based on Pilates method has influence on the static and dynamic postural balance of sedentary adults. This is a randomized controlled trial, which will be developed with an initial sample of 20 subjects of both sexes, aged between 18 and 30 years, divided into two groups: a control group and an experimental group. Participants with physical activity time up to 150 minutes per week will be included, assessed by the International Physical Activity Questionnaire (IPAQ), and those who have no experience with the Pilates method. In the experimental group a workout program will be done for 6 weeks with individual classes including exercises based on the Pilates method, during 1-hour, twice a week. Assessments will be made prior and after the training program with anamnesis, anthropometric measurements and also the Balance Error Scoring System and the Star Excursion Balance Test Y to assess postural balance. During the tests and training program exercises the muscle activity of paraspinals and transversus abdominis will be analyzed using surface electromyography (sEMG), and body mass center displacement will be measured with a triaxial accelerometer positioned on the fifth lumbar vertebra. The data will be entered in a spreadsheet and statistically tested with SPSS software. The tests will include the comparison of means, association, correlation and effect size, which will be chosen according to the distribution of the data and will use the 5% significance level for all tests.


Eligibility Criteria:
Inclusion Criteria:

* Sedentary
* healthy
* with no pilates experience

Exclusion Criteria:

* Physically active
* with history of injuries and surgery
Cognitive-Existential Group Therapy to Reduce Fear of Cancer Recurrence: A RCT Study

Studies show that cancer survivors have unmet needs, the most frequently cited being fear of recurrence (FCR). Moderate to high levels of FCR have been reported by as much as 49% of cancer patients and are more prevalent among women. FCR is associated with psychological distress, lower quality of life, and increased health care utilization. Little evidence exists that these problems are being addressed by current medical management.

The present study aims to further test this cognitive-existential group intervention for FCR in a randomized control clinical trial with women with breast or gynecological cancer. Participants will be recruited from Princess Margaret Hospital, Mount Sinai Hospital, the Jewish General Hospital, and the Ottawa Hospital. 144 cancer patients will be randomized to either receive the 6 week cognitive-existential group intervention or to a control group. The control group will also consist of six weekly sessions during which participants will discuss the challenges of living with a cancer diagnosis, but without a clear focus on FCR. Women randomized to participate in the study will a) be 18 years or older; b) have a first diagnosis of breast or gynecological cancer with stages between IIII; c) be disease free at the start of the group; d) gave clinical levels of fear of cancer recurrence; e) have clinical levels of distress; and f) have completed their cancer treatment.

Eligibility Criteria:
Inclusion Criteria:

1. first diagnosis of BC or GC with stages between I-III;
2. disease-free at the start of the group;
3. women aged 18 years or older;
4. completion of treatment, with the exception of adjuvant chemotherapy or hormonal replacement therapy

Exclusion Criteria:

1. non-English speakers
2. previous cancer recurrence
3. enrolled in another group psychotherapy at the time of the start of the study or during the course of the 6 sessions
4. unresolved mental health disorder judged to be clinically contra-indicated and/or likely to affect the group work, based on disclosure by the potential participant or clinically identified by the group leader.