cyrilzakka/clinical-trials huggingface dataset:
Nutritional Status and Hidradenitis Suppurativa (Acne Inversa)

Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. The objective of this study was to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naïve-treatment patients with HS. In the wake of this evidence, in the study to investigate the relationships between nutritional status, the adherence to the MD, body composition, and the severity of HS in a sample of naïve-treatment patients with HS compared to control group matched for sex, age, and body weight.


Eligibility Criteria:
Inclusion Criteria:

* healthy subjects of both gender
* treatment-naïve patients
* had HS diagnosed ≥6 months before study initiation wash out therapy for at least 3 months

Exclusion Criteria:

* occasional or current of use of drugs for HS, including topical antibiotics and systemic treatments (such as clindamycin-rifampicin, tetracycline, Rifampicin-moxifloxacin-metronidazole, ertapenem, acitretin, cyclosporine A, dapsone, isotretinoin, biologics;
* hypocaloric diet in the last three months or specific nutritional regimens;
* vitamin/mineral or antioxidant supplementation;
* occasional or current of use of drugs that could influence fluid balance, including non-steroidal anti-inflammatory drugs, hormone replacement therapy.
Pathological Classification of Pulmonary Nodules in Images Using Deep Learning

This study aimed to develop a deep-learning model to automatically classify pulmonary nodules based on white-light images and to evaluate the model performance. Besides, suitable operation could be chosen with the help of this model, which could shorten the time of surgery.

All white-light photographs of pulmonary nodules from phones of pathologically confirmed adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) were retrospectively collected from consecutive patients who underwent surgery between June 30, 2020 and September 15, 2021 at Guangdong Provincial People's Hospital.Finally, a total of 1037 white-light images from 973 individuals were included in the study. The entire dataset was divided into training and test datasets, which were mutually exclusive, using random sampling. Of these, 830 images were used as the training dataset and 104 images from were used as the test dataset. The CNN model was used in classifying images, namely, Resnet-50. For the CNN model, pretrained model with the ImageNet Dataset were adopted using transfer learning. After constructing the CNN models using the training dataset, the performance of the models was evaluated using the test dataset and the prospective validation dataset.

Eligibility Criteria:
Inclusion Criteria:

1. Male or female，18 years and older.
2. Patients haven't undergone any therapy.
3. The pulmonary nodules were confirmed AIS, MIA or IAC.
4. The sizes of pulmonary nodules were less than 3cm.
5. The images were jpg format.

Exclusion Criteria:

1. Suffering from other tumor disease before or at the same time.
2. Images with poor quality or low resolution that precluded proper classification.
Methylene Blue as a Third-line Vasopressor in Septic Shock

A randomized, prospective study comparing ProvayBlue® to standard care with multiple sympathomimetic vasopressors.

The study will be an un-blinded, Phase 2, randomized, 1:1, prospective trial comparing patients in septic shock receiving norepinephrine and vasopressin followed by phenylephrine versus ProvayBlue® as the third-line vasopressor. The third line vasopressor will be compared at 1 hour to see if it affects the patient's mean arterial blood pressure (MAP).

Eligibility Criteria:
Inclusion Criteria:

1. Meets Sepsis-3 Criteria (Suspected source of infection plus any 2 criteria of the qSOFA)

2 .Septic Shock (any patient requiring vasopressor therapy to maintain MAP \>65 mmHg or any patient with serum lactate \>2 mmol/dL even in the absence of hypovolemia ).

3) Greater than 18 years old

4 ) ICU Admission

Exclusion Criteria:

Inability to obtain informed consent from an appropriate surrogate decision maker.

Also:

1. Children less than 18 years old
2. Pregnant women or positive urinary pregnancy test in reproductive-aged women
3. Prisoners
4. Evolving myocardial infarction or known cardiomyopathy with documented EF\<35%
5. Known grade 3 diastolic dysfunction document by echocardiogram
6. Known hypersensitivity to thiazine dyes
7. Pulmonary hypertension that is currently requiring vasodilator therapy
8. Concurrent form of shock present or suspected: Obstructive, Neurogenic, Hemorrhagic
9. Known documented history of G6PD deficiency or favism
10. Active prior to admission medication prescription for a SSRI or SNRI , systemic heparin anticoagulation or other medications listed above (under Study Agent). These medications will be listed in the printed enrollment form.
11. Severe renal failure is a contraindication to use of ProvayBlue®.
Effects of Treatment of Sleep Apnea on Metabolic Syndrome

The investigators performed a randomized, cross-over controlled clinical trial comparing 8 weeks of Continuous Positive Airway Pressure (CPAP) to 8 weeks of sham-CPAP in patients with moderate to severe Sleep Disordered Breathing (SDB) and impaired glucose tolerance. A rigorous assessment of metabolic responses to SDB treatment in this group is of great clinical significance because this sample is at high risk for developing diabetes. The paradigm shift of CPAP as a mode of prevention can affect clinical practice in the fields of both primary care and sleep medicine.

There are few controlled studies that address whether treatment of sleep apnea improves glucose tolerance. This is a randomized, double-blind cross-over study of subjects with sleep apnea (apnea hypopnea index \> 15) and impaired glucose tolerance. Subjects will be randomized to 8 weeks of Continuous Positive Airway Pressure (CPAP) or sham-CPAP, followed by the alternate therapy after a one month wash-out. After each treatment, subjects will undergo 2-hour oral glucose tolerance testing, polysomnography, actigraphy, and measurements of indices of glucose control. The investigators intend to analyze the changes in glucose metabolism and insulin sensitivity in patients with sleep apnea with CPAP intervention.

Eligibility Criteria:
Inclusion Criteria:

* moderate to severe Sleep Disordered Breathing (SDB) defined by an Apnea Hypopnea Index (AHI) \> 15
* had evidence of Impaired Glucose Tolerance (IGT) defined by the mean 2-hour Oral Glucose Tolerance Test (OGTT) glucose of \> 140 mg/dl calculated from the two 2-hour OGTTs performed within 3 days of each other
The Investigation of Mechanical Properties in Obesity.

The study will demonstrate the relation between muscle tone and viscoelastic properties with the body mass index.

Obesity is an increasingly important health problem. It can be defined as excessive fat accumulation. Obesity is a low-severity systemic inflammatory condition that predisposes to chronic diseases.Obesity is closely related to adipose tissue, it can have direct or indirect effects on physical activity and musculoskeletal system. The systems working with oscillation techniques, subcutaneous tissue thickness may affect the probe stroke of the device and oscillation in the tissue. In previous studies were investigated mechanical properties, and BMI used as exclusion criteria is over 30 kg/meter square or keeping it at certain intervals (18-28 kg /meter square) but this proof is not demonstrated and still lack.This study is planned to determine the relation of mechanical properties (tone, stiffness and elasticity) obtained by myotonometric assessment with body mass index.

Eligibility Criteria:
Inclusion Criteria:

* Body mass index (range; 18 - 35 kg/meter square)

Exclusion Criteria:

* Had any systemic or metabolic disease, psychological illness, or drug use,
* Had any disease that may cause muscle disease or muscle atrophy,
* musculoskeletal surgery for the last 3 months
Thinking, Walking Outcomes by Type of Exercise

The purpose of this research study is to compare two different exercise treatments for walking problems in older adults. The investigators want to determine if participation in the exercise programs will improve walking and thinking abilities.

Specific Aims We will examine the impact of moderate intensity aerobic and of motor skill exercise interventions on improving gait and cognition in older adults with slow gait and psychomotor slowing. In a thrice weekly, 12 week, randomized clinical trial, we propose the following aims: 1) to define the impact of moderate intensity aerobic and motor skill gait exercise on thinking while walking, and 2) to define the impact of moderate intensity aerobic and motor skill gait exercise on gait and cognition. Brief Background The optimal exercise to improve gait and brain health in older adults is not known. Two types of exercise with potential for affects on gait and brain health, aerobic and motor skill exercise, developed out of distinct disciplines and have been studied separately, but not in older adults with the same age-related, centrally-generated slow gait dysfunction or for their effects on an integrated measure of gait and cognition, 'walking while thinking'. Summary of Methods We propose two parallel, single arm clinical trials to define the impact of aerobic and motor-skill exercise on gait and cognitive functions, in community-dwelling older adults with slow gait and psychomotor slowing, randomly assigned to moderate intensity aerobic gait (n=12) or motor skill gait (n=12) exercise, three times a week, for 12 weeks, in small groups of 2-3 supervised by a physical therapist. Primary outcomes are integrated measures of thinking while walking, with secondary outcomes of specific measures of gait and cognitive function collected pre, 4, 8 and 12 weeks post interventions, to examine impact of exercise and dose-response effects on gait and cognition. Future Use of Data The intent of the proposed pilot is to generate complementary data essential to support an R01 clinical trial grant submission. Specifically in this pilot we will: 1) recruit older adults with both slow gait speed and evidence of psychomotor slowing, 2) explore and define a primary outcome measure that integrates both gait and cognition, and thus better represents the goal of the exercise interventions - thinking while walking, 3) determine potential mean and variability estimates for gait and cognitive outcomes, particularly the less well-characterized gait outcomes of aerobic exercise (energy expenditure for walking, gait variability, gait abnormalities), and cognitive outcomes of motor skill exercise (speed of processing, executive function).

Eligibility Criteria:
Inclusion Criteria:

* slow gait speed (\<= 1.0m/s and \>= .6m/s)
* slow cognitive processing (digit symbol substitution \< age-adjusted norm
* medical clearance from primary physician for participation in exercise

Exclusion Criteria:

* dementia or Mild Cognitive Impairment MCI
* pain while walking that limits walking
* active medical conditions, not controlled or managed
Efficacy and Safety of Ultra Small Dose Decitabine for the Lower Risk MDS Patients With Transfusion Dependent

Myelodysplastic syndrome (MDS) is widely recognized as a clonal hematopoietic stem cell disorder. Decitabine has been approved for the treatment of all subtypes of myelodysplastic syndrome (MDS). However, the use of decitabine is often limited by its severe toxicity represented by myelosuppression even at relatively low doses. In lower-risk patients (including IPSS low and int-1 risk groups), treatment mainly aims at improving cytopenias, especially anemia. However, although several drugs may improve anemia, sometimes durably, most of lower risk MDS eventually require red blood cell (RBC) transfusions during their disease course. Long term RBC transfusions lead to iron overload mainly due to an increase in reticulo-endothelial iron recycling.Cardiac, liver and endocrine (diabetes mellitus) dysfunction due to iron overload and often leading to fatal outcome has been reported in heavily transfused lower risk MDS patients.

To date, the optimal regimen for decitabine treatment is not well established. In this study, we perform a prospective analysis to explore the decitabine schedule for the treatment of lower risk myelodysplastic syndrome patients with transfusion dependent.

The investigators are undertaking a single-center, single-arm study of 50 lower risk myelodysplastic syndrome patients with transfusion dependent from Shandong University Qilu Hospital . All the participants are selected to receive ultra small dose decitabine treatment (given intravenously at a dose of 3.5mg/m2, qd x 5d, every four weeks for one cycle). A routine blood examination is performed twice every week. Bone marrow (BM) is examined with routine aspirate smear and G-banding analysis every 1-2 treatment courses to evaluate responses.Adverse events are also recorded throughout the study.

Eligibility Criteria:
Inclusion Criteria:

* diagnosis of MDS
* The IPSS \[17\] score ≤ 1
* patients with transfusion dependent
* Adequate hepatic and renal function (aspartate aminotransferase \[AST\] ≤ 2.5 x upper normal limit, alanine aminotransferase \[ALT\] ≤ 2.5 x upper normal limit, bilirubin ≤ 1.5 x upper normal limit and creatinine \< 2 x upper normal limit, Ccr \> 60ml/min ).

Exclusion Criteria:

* Decitabine and Arsenic trioxide allergy
* Pregnancy and lactation
* Cardiovascular disease
* ECOG score \> 2
* HCV, HIV, HBsAg seropositive status
Neuroendocrine and Immune Response to Stress in Schizophrenia

This is a pilot study. We are testing the physiologic, immune and chemical responses to stress. We believe the results of all measures to stress will be blunted in schizophrenia compared to healthy controls. We will test sex, early life stress and other factors on the relationship to a stress response.

The proposed study examines the response of neuroimmune and inflammatory responses to a stress in both men and women with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder. The measurements include stress hormones or other elements in the blood which indicate stress . Early childhood trauma/stress (ELS) information will be collected so we can examine differences in those with trauma histories vs. those with none by sex. There will be one visit for screening before the testing visit. The sample will consist of up to 45 clinically stable inpatients and outpatients with DSM-IV schizophrenia or schizoaffective disorder, of which approximately 15 will be women. We will also enroll up to 45 healthy controls without a DSM-IV Axis I or II disorder. Prior to the study all subjects must meet inclusion and exclusion criteria including a medical history.

The (TSST) is a standard and widely used research assessment procedure that is used to reliably induce stress in human research participants. The TSST uses situations where people think they are being socially evaluated during an interview for a job. Participants are told they are competing with other people for this job, and their task is to convince interviewers that they are the best person for the job. Participants are told they have to prepare a speech, and complete a math challenge in their head.

Eligibility Criteria:
Inclusion Criteria:

* DSM-IV diagnosis of schizophrenia or schizoaffective disorder (schizophrenia group)
* No DSM-IV Axis I or II disorder (healthy control group)
* Caucasian or Non-Caucasian

Exclusion Criteria:

* History of Cushing's syndrome, adrenal deficiency, or any condition that may affect cortisol levels in the body.
* Use of steroids
* Pregnancy or lactation. Pregnancy will be determined by urine pregnancy test. Lactation will be determined through patient report.
* Untreated hypertension, cardiac arrthymias or medical condition that could not handle stress.
Fecal Microbiota Transplantation (FMT) in the Management of Hepatic Encephalopathy (HE): a Pilot Study

The purpose of this study is to determine if FMT can reverse Hepatic Encephlopathy (HE) in cirrhotic patients who continue to have breakthrough episodes of HE despite maintenance therapy with lactulose and/or rifaximin or metronidazole.

Subjects receive FMT from a single donor by colonoscopy at Week 0 and by enema at Weeks 1-4. HE is measured by Inhibitory Control Test and Stroop as well as serum ammonia levels.

Eligibility Criteria:
Inclusion Criteria:

1. adult (age \> 18 years of age) cirrhotic patients of various etiology, on lactulose and/or rifaximin or flagyl for at least 4 weeks as secondary prophylaxis
2. abnormal inhibitory control test, defined as greater than 5 lures.
3. an infectious etiology which may cause HE has been ruled out

Exclusion Criteria:

1. those with tense ascites
2. those who do not provide assent
3. those who are judged to have a life expectancy of less than 3 months,
4. those who had TIPS within 3 months,
5. those with neurologic diseases such as dementia, Parkinson's disease, and structural brain lesions
6. pregnancy
7. those with intestinal obstruction
8. those with alcoholic hepatitis
9. those with active alcohol or substance abuse
10. those without stable social support
11. those who have a concurrent infection, such as SBP, pneumonia or UTI
12. those with creatinine clearance less than 50% compared to baseline
13. those with recent hospital admission, defined as within one month of enrollment, for hepatic encephalopathy
Collection of Blood Specimens for Circulating Tumor Cell Analysis

Objective: To test the sensitivity of a proprietary novel filtration device designed to capture and concentrate circulating tumor cells (CTCs).


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years of age
* Written informed consent obtained
* Confirmed diagnosis of stage 2-4 breast, prostate, or colorectal cancer, (OR) no prior history of cancer
* Stage 2-4 treatment naive, metastatic, secondary, and recurrent cancer patients
* Able to undergo blood collection prior to initiation of chemotherapy treatment, (OR) able to provide blood sample if subject is a non-cancer control subject

Exclusion Criteria:

* Patients unable to understand the research protocol and/or provide informed consent.
* Patients with known immunodeficiency, or pregnancy.
Developing and Pre-Testing an eHealth Group Intervention for Young Adult Cancer Survivors

The purpose of this study is to develop and pre-test an eHealth group intervention for young adult cancer survivors.

In the first part of this study, the investigators adapted an evidence-based intervention for improving HRQOL to better meet the needs of young adult cancer survivors, and then conducted focus groups with young adult cancer survivors to get feedback on the adapted intervention. In the second part of the study, the investigators will conduct a single-arm pilot trial in which the adapted intervention will be delivered over videoconference via weekly group meetings with a trained facilitator over the course of 10 weeks.

Eligibility Criteria:
Inclusion Criteria:

* age 18-39 years at the time of participation
* diagnosed with a non-metastatic primary cancer between 18-39 years old
* completed primary cancer treatment (excepting hormone therapy) 1 month to 5 years prior to enrollment
* able to speak and read English
* access to internet or cellular connectivity with sufficient bandwidth to participate in videoconferences

Exclusion Criteria:

* metastatic disease
* psychiatric or neurological disorders that could interfere with study participation
* considered part of a vulnerable population
Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound

This study aims to evaluate the effect of non-invasive ventilation (nIPPV)

, (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates \<37 gestational week with moderate to severe RD using LUS as regard: I. Primary outcomes: Duration of non-Invasive ventilation. II. Secondary outcomes: Evaluation LUS over the 1 st 7 days of life or weaning from ventilation. Need for intubation and invasive ventilation. Duration of respiratory support. Need for surfactant. Oxygen saturation index and oxygen index. Broncho-pulmonary dysplasia; grade. Duration of hospital stay


Eligibility Criteria:
Inclusion Criteria: Preterm \<37 wk. gestational age admitted to the NICU with spontaneous breathing and clinical manifestations of RD (tachypnea, nasal flaring, intercostal and subcostal retraction and or grunting).

Exclusion Criteria:

1. Obvious major congenital abnormalities.
2. Any of the baby intubated for resuscitation or for other reasons.
3. Neonates need invasive mechanical ventilation.
4. Pulmonary hemorrhage.
5. Severe cardiovascular instability.
6. Cardiopulmonary arrest needing prolonged resuscitation.
7. Birth asphyxia (one-minute Apgar score ≤ 3).
8. Major cardiac diseases (not including patent ductus arteriosus).
The Influence of Factors on Accuracy of Reported Dietary Intake

The purpose of this study is to evaluate the influence of dietary restraint, social desirability, and food type on the accuracy of dietary intake reported during a 24-hour recall.

The purpose of this study is to investigate the influence of the interaction among dietary restraint, social desirability, and food type ("healthy" vs. "unhealthy") on the accuracy of reporting consumption of a laboratory meal during a 24-hour dietary recall. The automated multiple-pass method (AMPM) of 24-hour dietary recall is considered the gold standard of dietary assessment however the potential for error and biases is widely acknowledged with a tendency towards underreporting. Underreporting has been linked to many factors including two individual characteristics, dietary restraint and social desirability. Both dietary restraint and social desirability have been extensively studied however the influence of their interaction on reported dietary intake is not fully understood. In addition, a relationship to the types of foods (healthy vs. unhealthy) has also been found. For this study, 40 normal-weight female participants will be recruited at The University of Tennessee using flyers inviting volunteers. Participants will be categorized by dietary restraint, high or low, and social desirability, high or low, based on questions during the initial screening. In a laboratory setting participants will consume a meal of pre-weighed foods, including both "healthy" and "unhealthy" foods. The following day, an AMPM 24-hr dietary recall will be conducted with the participant over the telephone. Accuracy of the reported dietary intake of the laboratory meal will be determined by the equation \[(reported intake - measured intake)\]/measured intake\] x100 for amount (weight or volume) and energy (kilocalories) with comparisons between groups and within food types using mixed factorial analysis of variance.

Eligibility Criteria:
Inclusion Criteria:

* Normal weight status (BMI 18.5-24.9)
* Willing to sample study foods

Exclusion Criteria:

* Individuals majoring in Nutrition or Exercise Science
* Smokers
* Individuals taking medication for ADHD
* Individuals who are pregnant
* Individuals with allergies to food in study
Comparison of Laser Lithotripsy With and Without Steerable Ureteroscopic Renal Evacuation (SURE)

The purpose of the study is to compare the effects, good and/or bad, of a treatment for removing kidney stones called the SURE procedure for stone evacuation to the standard treatment using a basket for stone removal.


Eligibility Criteria:
Inclusion Criteria:

* Candidate for ureteroscopy with laser lithotripsy;
* Presence of renal stone(s);
* Be willing and able to return for all study-related follow up procedures; and,
* Have been informed of the nature of the study, agreeing to its requirements, and have signed the IRB approved informed consent.

Exclusion Criteria:

* BMI \> 45;
* Significant comorbidities;
* Bladder, ureteral or kidney abnormalities;
* Pregnant individuals; or
* Unable to meet the treatment and follow up protocol requirements.