IN-USE TOLERANCE STUDY UNDER DERMATOLOGICAL AND OPHTHALMOLOGICAL CONTROLS AND EFFICACY ASSESSMENT (Face Cream)

The aim of this study is to assess the dermatological and ophthalmological tolerance of the investigational product Crème visage / Face cream RV4941A - RY1987 after 21 days of twice daily use on the study areas, under normal conditions of use.

The aim of this study is also to:

* evaluate the cutaneous sensitivity by a stinging test at D1 T0 and D22.
* evaluate the cutaneous sensitivity by a sensitive scale at D1 T0, D1 Timm\*, D8 and D22.
* evaluate the soothing efficacy by an efficacy questionnaire at D1 Timm\*, D8 and D22.
* evaluate the cosmetic acceptability by a questionnaire at D22.

This study is conducted as a national, monocentric, non-randomized open trial. The 33 subjects in this study present hypersensitive, reactive and intolerant skin on face. They are stinger subjects, with a normal to combination skin.

Timm\*: 10 to 30 minutes after first application

This study is a national, monocentric, non-randomized open trial, conducted in adults presenting hypersensitive, reactive and intolerant skin on the face, with a normal to combination skin.

The study includes 3 visits, including subjects' selection:

* V1: Baseline inclusion
* V2: 1 week, intermediate visit
* V3: 3 weeks, study end

The maximal study duration is 25 days.

The evaluation is at 3 times: D1 baseline, D8 at 1 week and D22 at 3 weeks of application of RV4941A - RY1987 with comparison of each time versus baseline.

There are twice-daily applications (morning and evening) of the test product on the face.

Eligibility Criteria:
Inclusion Criteria:

1. Criteria related to the population:

   * Male or Female aged between 18 and 65 years included
   * Asian population (Chinese origin)
   * Normal to combination skin on the face
   * Subject with phototype I to IV included
   * Subject having signed his/her written informed consent for his/her participation in the study
   * Subject who is currently not participating in another clinical study
   * Subject affiliated to a social security system or health insurance, or is a beneficiary
   * For woman of childbearing potential: use of an effective method of contraception and using it during the whole duration of the study
2. Criteria related to diseases and general health:

   * Stinger subjects (evaluated by a stinger test)
   * Subject with hypersensitive, reactive and intolerant skin on face
   * Subject having a score superior to 4 on a sensitive scale for tightness parameter on the face
   * Subject having a score superior to 4 on a sensitive scale for general discomfort parameter on the face

Exclusion Criteria:

1. Criteria related to the population:

   * For woman of childbearing potential: subject pregnant or breastfeeding or planning to be pregnant during the study
   * Having a dermatological condition liable to interfere with the study data or considered by the Investigator hazardous for the subject or incompatible with the study requirements
   * Having an ophthalmological condition liable to interfere with the study data or considered by the Investigator hazardous for the subject or incompatible with the study requirements
   * Having personal medical history liable to interfere with the study data for the subject or incompatible with the study requirements
   * Having history of abnormal reactions from exposure to sunlight
   * Having taken any previous treatment considered by the Investigator liable to interfere with the study data or incompatible with the study requirements
   * Being under any treatment considered by the Investigator liable to interfere with the study data or incompatible with the study requirements
   * Subject who is not likely to be compliant with study-related requirements
   * Subject deprived of freedom by administrative or legal decision or under guardianship
2. Criteria related to investigational product application areas:

   * Having had any surgery, chemical or significant invasive dermo-treatment on the experimental area considered by the Investigator liable to interfere with the study data, before the inclusion visit or foreseeing it for the duration of the study
   * Having applied a skincare or make up product on the study areas the day of the inclusion visit. The usual cleanser is allowed
   * Having received, on the study areas, artificial UV exposure or excessive exposure to natural sunlight within the 2 weeks before the inclusion visit (at Investigator's opinion)