cyrilzakka/clinical-trials huggingface dataset:
Clinical Evaluation of Two Toric Contact Lenses

The study objective was to compare short-term clinical performance data of two toric contact lenses.

The aim of this non-dispensing fitting study was to evaluate the short-term clinical performance of a monthly toric contact lens when compared to a daily disposable toric contact lens after 15 minutes of daily wear each.

Eligibility Criteria:
Inclusion Criteria:

* Is between 18 and 40 years of age (inclusive)
* Has had a self-reported visual exam in the last two years
* Is an adapted soft contact lens wearer
* Is not a habitual wearer of either study lens
* Has a contact lens spherical prescription between +4.00 to -9.00 (inclusive) best corrected visual acuity of 20/30 or better in either eye
* Have contact lens prescription of no less than -0.75D of astigmatism and no more than -2.25 D in both eyes.
* Can achieve best corrected spectacle distance visual acuity of 20/25 (0.10 logMAR) or better in each eye.
* Can achieve a distance visual acuity of 20/30 (0.18 logMAR) or better in each eye with the study contact lenses.
* Has clear corneas and no active ocular disease
* Has read, understood and signed the information consent letter.
* Patient contact lens refraction should fit within the available parameters of the study lenses.
* Is willing to comply with the wear schedule (at least 5 days per week, \> 8 hours/day assuming there are no contraindications for doing so).
* Is willing to comply with the visit schedule

Exclusion Criteria:

* Has a CL prescription outside the range of the available parameters of the study lenses.
* Has a spectacle cylinder less than -0.75D or more than -2.50 D of cylinder in either eye.
* Has a history of not achieving comfortable CL wear (5 days per week; \> 8 hours/day)
* Has contact lens best corrected distance vision worse than 20/25 (0.10 logMAR) in either eye.
* Presence of clinically significant (grade 2-4) anterior segment abnormalities
* Presence of ocular or systemic disease or need of medications which might interfere with contact lens wear.
* Slit lamp findings that would contraindicate contact lens wear such as:
* Pathological dry eye or associated findings
* Pterygium, pinguecula, or corneal scars within the visual axis
* Neovascularization \> 0.75 mm in from of the limbus
* Giant papillary conjunctivitis (GCP) worse than grade 1
* Anterior uveitis or iritis (past or present)
* Seborrheic eczema, Seborrheic conjunctivitis
* History of corneal ulcers or fungal infections
* Poor personal hygiene
* Has a known history of corneal hypoesthesia (reduced corneal sensitivity)
* Has aphakia, keratoconus or a highly irregular cornea.
* Has Presbyopia or has dependence on spectacles for near work over the contact lenses.
* Has undergone corneal refractive surgery.
* Is participating in any other type of eye related clinical or research study.
Evaluation of The Accuracy of Zygomatico- Maxillary Complex (ZMC) Fractures Reduction Using Patient Specific Guide (PSG) Versus Conventional Technique

Evaluation of The Accuracy of Zygomatico- Maxillary Complex (ZMC) Fractures reduction Using Patient Specific Guide (PSG) Versus Conventional Technique


Eligibility Criteria:
Inclusion Criteria:

* • Zygomatic Fracture Type III, IV and V according to rowe and killey classification(13)

  * Age (18-60 years)
  * Recent fracture (less than 2 weeks)

Exclusion Criteria:

* • Zygomatic Fracture Type I, II and VI according to rowe and killey classification(13)

  * Medical compromised patient
  * Patient on radiotherapy
  * Bone disease
Underutilization of Hospice Care in Older Black Adults

This study will sample older Black adults to test their knowledge and opinions of hospice.

Short stays in hospice strain the Medicare system. Black adults over age 65 are one of the fastest growing groups in the US. Despite greater disease burden than their White peers, older Black adults are less likely to enroll in hospice. Misconceptions about hospice and mistrust may contribute to this disparity. The research will seek to understand older Black adults' decision-making processes around hospice. The PtDA is a tool to assist in this decision-making process. The influence of this tool will be measured as well. The sample of older Black adults will represent the national population. The research will explore various subgroups, which previous research has been unable to address. This study will use four validated survey batteries. About 200 of the 400 participants will also review the decision aid. These adults will complete a second survey. About 20 of these adults will also complete an interview about the decision aid. Through the surveys and interviews, this research will explore barriers to hospice usage for older Black adults.

Eligibility Criteria:
Inclusion Criteria:

* Identifies as Black or African American
* Can read and write English

Exclusion Criteria:

* Unable to read/write English
* Have a cognitive impairment that prevents them from providing informed consent
Effects of Rhythmic Stabilization With and Without Closed Kinetic Chain Exercises Among Fast Bowlers

Effects of Rhythmic stabilization with and without Closed Kinetic Chain Exercises on upper body strength, endurance and balance among fast bowlers

The literature mostly ignores the specific needs of fast bowlers in favor of concentrating on general strength and fitness for cricket players. Exercises for rhythmical stabilization, which improve neuromuscular control and stability, are not given much attention. There is not enough research done on closed chain workouts in cricket-specific contexts. Closed chain exercises replicate the weight transfer and ground response forces during quick bowling. There is a paucity of literature offering fast bowlers-specific evidence-based training routines, despite the unique demands of cricket. Coaches and practitioners are less able to create interventions that target the specifics of the fast bowling motion in the literature because there aren't many exercises specifically designed for cricket.

Eligibility Criteria:
Inclusion Criteria: Male athlete (16) Age of 18-35 years (17) Minimum of 6 months training experience (18) Healthy weight with BMI in category of 18.5 to 24.9 (15).

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Exclusion Criteria: Joint or bone disease such as rheumatoid arthritis or osteoarthritis of the upper extremity (19).

Cervical spine pathology (20) Serious injury or history of surgery in the past year Any recent upper limb fracture Chronic limb discomfort or limitations that had a negative effect on exercises (e.g., shoulder pain and lateral epicondylitis) (20) Shoulder instability to be tested via load and shift test (21).
ACT-HF: Attention, Cognition and Self-Management in Heart Failure

This study is designed to determine if a relationship exists between problems with memory, attention, learning, insight and executive function and self management in heart failure.

Eligible participants are those 75 years of age or less, with left ventricular ejection fractions of 40% or less, english speaking and no known cognitive deficits. Participants will be administered the Repeatable Battery for the Assessment of Neuropsychological Status and the Controlled Oral Word Association test at the study visit. They will also be asked to complete the Self-Care in Heart Failure Index and the Anosognosia Questionnaire for Dementia at their convenience and mail back to investigator. Participants will be contacted in 90 days to determine if they have been hospitalized, and if so, for how many days.

Eligibility Criteria:
Inclusion Criteria:

* 75 years of age or less
* ejection fraction 40% or less
* heart failure 6 months or more
* English speaking
* no known dementia
* no active substance abuse
* presence of caregiver/support

Exclusion Criteria:

* neurologic disorders potentially causing cognitive dysfunction
Health and Health Care Utilization Effects of Medical Debt Forgiveness

The goal of this study is to estimate the direct, causal impact of medical debt on health care utilization, mental health, and wellbeing of patients. The investigators will conduct a survey to measure the impact of the debt forgiveness on health care use, mental health, and wellbeing. The survey will be administered to approximately 17,000 subjects of a recent medical financial intervention. In that prior intervention, a non-profit charity, RIP Medical Debt, purchased and abolished medical debt for a randomly selected about 6,000 (out of the 17,000) individuals. In this current protocol, the investigators will administer the survey, and will compare surveyed outcomes of subjects who received and did not receive the intervention.

This study will estimate the direct, causal impact of medical debt on health care utilization, mental health, and wellbeing of patients. To do so, the investigators will administer a survey to approximately 17,000 subjects of a recent medical financial intervention. In that intervention, a non-profit charity, RIP Medical Debt, purchased and abolished medical debt for a randomly selected about 6,000 (out of the 17,000) study subjects. In this current protocol, the investigators will compare surveyed outcomes of subjects who received and did not receive the medical debt abolishment intervention. Because debt abolishment was randomized, comparing surveyed outcomes of treated and control subjects in the cross-section will allow the study to estimate the causal impact of the medical debt abolishment. The survey will measure the effects of medical debt on three sets of outcomes: (i) health care utilization, as measured by medical care visits, prescription drug utilization and adherence, and unmet need for medical care; (ii) mental health, as measured by validated screens for depression and anxiety; and (iii) subjective wellbeing, as measured by self-reported health, forgone consumption, and financial strain. This study would be the first to provide a direct, causal connection between the rising personal debt associated with U.S. health care and the health outcomes of its recipients.

Eligibility Criteria:
Inclusion Criteria:

* Individuals ages 18 and over who owed medical debt to FFAM, a debt collections agency

Exclusion Criteria:

* Excluded individuals who owed less than $500 in medical debt to FFAM
* Excluded individuals with missing social security numbers
The Feasibility of the Peer-based Recovery Program

Recovery-oriented services are currently the mainstream in the field of mental health around the world. Peer services are an alternative service option promoted by recovery advocates. Western countries have invested abundant resources in promoting peer services and providing training for peer support workers. However, peer services in Taiwan have just started. More resources need to be added to make mental health services catch up with the world trend so that people with mental illness in Taiwan can have more choices. Hence, this study aims to investigate the feasibility of the Grow to Recovery program-Short Version co-led by a peer.

The study will verify the feasibility of the Grow to Recovery program-Short Version co-led by a peer. Based on the previous interview data and related literature, a peer leader training course will be established. One to three peers will be recruited to receive the training, and colead the Grow to Recovery program-Short Version with one trained professional. The pre- and post-test as well as course questionnaire data collected from program participants will be used to establish the feasibility.

Eligibility Criteria:
Inclusion Criteria:

* Professionals:

  1. working in the community psychiatric rehabilitation organizations
  2. being willing to co-lead the recovery program with a peer
* Peers:

  1. having a diagnosis of mental illness over 1 year
  2. living in the community
  3. being age 18 yr or older
  4. having good communication skills
  5. being willing to co-lead the recovery program with a professional
* People with mental illness

  1. having a diagnosis of mental illness over 1 year
  2. living in the community
  3. being age 18 yr or older
  4. filling out the scales independently
  5. being able to participate in a recovery group and follow the group rules

Exclusion Criteria:

* People with mental illness 1. attending another recovery-related group
MOON Onsite MRI 10 Years After ACL Reconstruction

In this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study already will be called back to have MRI. PROMs and other information of these subjects will be collected through the MOON study.

In this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study already will be called back to have MRI. PROMs and other information of these subjects will be collected through the MOON study.

In addition, 30 age-, sex- and BMI-matched control subjects (10 from each site) will be recruited and scanned for MRI. PROMs (KOOS, IKDC, Marx, SF-36) will be collected from these controls.

Among the 10 controls recruited locally at CCF, five will also travel to OSU and Vanderbilt to be scanned at the other two sites for cross-validation among the three sites. There will be a separate consent for the 5 controls that will be traveling to each of the 3 sites for the scans. The remaining 25 controls will be tested at only their local site.

Eligibility Criteria:
Inclusion Criteria:

* Enrolled in MOON Onsite Study
* 12-33 years old at baseline (22-45 years for this study);
* ACL tear during a sport; no previous knee injury;
* No graft rupture during follow-up;
* No history of surgery on the contralateral knee;
* No MRI contraindications

Exclusion Criteria:

* History of surgery on contralateral knee
* Afraid of enclosed spaces
Weight Watchers Online

The purpose of this study is to conduct a randomized controlled trial to compare the weight losses produced by the Weight Watchers Online program (WWO) and WWO plus the Philips ActiveLink physical activity system, over a 1-year period, compared to a control group.


Eligibility Criteria:
Inclusion Criteria:

* Body mass index (BMI) between 27 and 40 kg/m2
* All ethnic groups will be recruited
* English speaking
* Have access to the Internet via a computer, and basic computer skills

Exclusion Criteria:

* Report health problems that make weight loss or unsupervised exercise unsafe or unreasonable
* Report a heart condition, chest pain during periods of activity or rest, or loss of consciousness on the Physical Activity Readiness Questionnaire
* Are currently pregnant or breastfeeding, or intend to become pregnant in the next 12 months
* Are planning to move outside of the state within the next 12 months
* Report any cognitive or physical limitations that preclude use of a personal computer
* Have participated in a study conducted by the WCDRC or UT in the past 2 years
* Have followed a commercial weight-loss program within the previous 6 months or who are currently following a commercial weight loss program
* Weight loss of ≥ 5% of initial body weight in the last 6 months
* History of clinically diagnosed eating disorder excluding Binge Eating Disorder.
* Previous surgical procedure for weight loss
* Currently taking weight loss medication
* Treatment of cancer within the last 6 months
Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)

Adolescent idiopathic scoliosis (AIS) is a complex deformity with different curves. These different curves may be distinguished by different physiopathologic mechanisms.

Without fully convincing model of the emergence and development of AIS, their multifactorial nature seems evident. Several pathophysiological theories involving the central nervous system have been proposed: the AIS would be associated with disturbances of proprioceptive or sensory perception, and/or with integration of this information. This would result in an abnormal body image, responsible for sensorimotor asymmetry that may promote or cause the deformation.

The Main aim of this study is to find cortical and subcortical morphometric differences in the most common population of AIS (right thoracic AIS) compared to healthy adolescent control girls.

Secondary Objectives are to study the cerebral white matter of the same groups (fractional anisotropy in the main white matter tracts), and activation of sensorimotor neural networks (fMRI activation and functional brain connectivity).

Abnormalities of the studied parameters may be used as biomarkers for AIS diagnosis and classification.


Eligibility Criteria:
Inclusion Criteria:

* female
* between 14 and 16 years old
* normal neurological examination
* right handed
* informed consent
* informed consent form signed by a parent or a holder of parental authority
* affiliated to medical insurance
* negative urine pregnancy test For patients (A-STD) : right thoracic scoliosis with a Cobb angle between 20 and 40° For healthy volunteers (A-N) : no clinical scoliosis

Exclusion Criteria:

* pregnant or lactating woman
* antecedents of cranial trauma or cranial intervention, of migraine, of spinal trauma, of scoliosis intervention
* no idiopathic scoliosis
* contraindications to MRI
* patient with a legal protection measure
Detecting the Changes of Swallowing Function in Oral Cancer Patients

The evidence of swallowing changes in tongue cancer patients is still limited. This study aimed to investigated the swallowing changes in these patients by using the videofluoroscopy (VFSS) and high resolution impedance manometry (HRIM).

Objective: to investigated the swallowing changes in tongue cancer patients by using the videofluoroscopy (VFSS) and high resolution impedance manometry (HRIM).

Methods: 1. patients are fulfilled tongue cancer diagnosis; 2.they will undergo VFSS and HRIM examinations before or after surgery if they experience discomfort while swallowing.

Eligibility Criteria:
Inclusion Criteria:

* patients elective received oral cancer surgery and suitable to receive mandibular-lip split or pull-through resection surgeries

Exclusion Criteria:

* 1. patients had major underlying disease, ex: heart, brain, lung, liver disease
* 2. coagulopathy
* 3.pregnancy
* 4. the patients could not have good compliance
Improving the Quality of Care for Atrial Fibrillation by Promoting Patient-Centered Decision Making

The primary aim of this proposal is to determine the effectiveness of a decision support tool on improving the process of shared decision-making for treatment on nonvalvular atrial fibrillation (NVAF) compared to receipt of usual care.

Decision-making regarding appropriate therapy for non-valvular atrial fibrillation (NVAF) is a complex process. Different options carry with them different profiles of risks and benefits, and choosing the "right" therapy depends upon the patient's understanding of these risks and benefits and a consideration of the risks and benefits according to the patient's values and preferences. Studies have shown that patients' preferred therapy frequently disagrees with what is recommended by disease management guidelines.

The purpose of this study is to examine an intervention to improve the quality of decision-making for NVAF compared to usual care. The intervention has several components, including: a) educating the patient about why values and preferences are important to the decision-making process, b) providing an individualized assessment of the risks and benefits of each of the treatment options, c) exploring patients' values and preferences as they relate to the risks and benefits of each of the treatment options, d) preparing the patient to discuss his/her preferences with the physician.

Eligibility Criteria:
Inclusion Criteria:

* 45 years or older
* Be scheduled to see primary Doctor at VA
* Diagnosis of atrial fibrillation
* English speaking

Exclusion Criteria:

* Have valvular disease as the cause of Afib
* Be on warfarin for a condition other than NVAF
* Have a contraindication to warfin
* Have a contraindication to ASA
* Life expectancy of less than 12 months
* Cognitive impairment
* Receiving anti-platelet agent other than aspirin
* Receiving care in a supervised resident clinic or from an attending physician who refuses participation in the study
* Bleed with identified source in the last 12 months
* Bleed with an unidentified source
* History of intracerebral hemorrhage
* Severe hearing impairment
* Severe visual impairment
Chronic Pain After Video-assisted Thoracoscopic Surgery (VATS) Surgery for Pneumothorax

The study will investigate characteristics of chronic pain after VATS surgery with two different sizes of videoscopic equipment.


Eligibility Criteria:
Inclusion Criteria:

* PSP
* Able to understand and give consent
* Can read
* Residing in Denmark

Exclusion Criteria:

* Unable to understand the written information in Danish
* Abuse (Medicine, Drugs, Alcohol)
* Severe psychiatric Illness
* Conflicting neurological disease
* Conversion to open surgery
* Use of neuroaxial analgesia
* Use of electric cauterizer necessitated
* Additional thoracic surgery in the investigation period
Regulation and Signaling of Red Blood Cell (RBC) Endothelial Nitric Oxide Synthase (eNOS) in Patients With Stable and Unstable Coronary Artery Disease

The aim of this study is measurement of expression and activity of RBC eNOS in different clinical cohorts of patients with coronary artery disease and acute coronary syndrome and to investigate the importance of the NO-stimulated reaction cascade in terms of sGC and PKG.


Eligibility Criteria:
Inclusion Criteria:

* informed consent
* for ACS(acute coronary syndrome)-Group: angiographic coronary artery disease; acute coronary syndrome, defined by EITHER unstable angina pectoris with significant coronary stenosis (troponin negative, without significant ST-elevation) OR low-risk NSTEMI (Troponin positive, without significant ST-elevation)
* for stable CAD-Group: angiographic coronary artery disease; no acute coronary syndrome within the last 3 months
* healthy control group: No clinical or angiographical signs of apparent atherosclerosis

Exclusion Criteria:

* acute inflammation (CRP \> 1 mg/dl, leukocyte \> 11.000/µl)
* malignant diseases
* pregnancy
* medication with NO-donors ( e.g.isosorbide mononitrate, isosorbide dinitrate, glyceryl trinitrate, Molsidomin, Ranexa)
* patients with STEMI or high-risk NSTEMI
OPIOID Study - Pain With Osmotic Dilators

Comparison of pain levels and pain medications utilized following insertion of two different types of osmotic dilators.

This is a randomized controlled trial to assess and compare pain levels and pain medication needs following placement of Laminaria versus Dilapan-S for cervical preparation prior to second-trimester dilation and evacuation (D\&E) procedures. Pain levels and medication usage will also be assessed following the D\&E procedure itself, up to 7 days after the procedure.

Eligibility Criteria:
Inclusion Criteria:

* scheduled D\&E for 15+0 to 23+6 wga
* ability to speak and read in English
* ownership of smartphone with internet access and data plan

Exclusion Criteria:

- chronic pain, fibromyalgia, active pelvic infection, inability to take NSAIDS, current use of narcotics
Recombinant Factor VIIa in Acute Intracerebral Haemorrhage

This trial is conducted in North America, Europe, Asia and Oceania. The purpose of this study is to evaluate safety and efficacy of Recombinant Factor VIIa in patients with acute intracerebral bleeding.


Eligibility Criteria:
Inclusion Criteria:

* Spontaneous intracranial haemorrhage (ICH) within 3 hours after first symptom

Exclusion Criteria:

* Patients with secondary ICH
* Pre-existing disability
* Haemophilia