cyrilzakka/clinical-trials huggingface dataset:
Motor Learning and tDCS in Parkinson's Disease

The present study sought to examine the efficacy of single session transcranial direct current stimulation applied over the primary motor cortex in people with Parkinson's disease on sequential motor learning performance.

Parkinson's disease is characterised by deficits of motor control triggered by impaired basal ganglia function, such as bradykinesia and tremor. Beyond the visibly recognisable motor symptoms of Parkinson's disease, the ability to learn a sequence of movements is also compromised and poses a significant barrier to effective rehabilitation. In healthy individuals, transcranial direct current stimulation applied over the primary motor cortex during motor task practice has been shown to significantly improve motor learning compared to placebo conditions. The present study sought to examine the effect of a single session of transcranial direct current stimulation applied over the primary motor cortex in people with Parkinson's disease on sequential motor learning performance. Participants learnt two finger tapping sequences, with task difficulty indexed by sequence length, and task consolidation further examined using a dual-task paradigm. Task related cortical haemodynamic activity was recorded using functional near-infrared spectroscopy.

Eligibility Criteria:
Inclusion Criteria:

* Right-handed (Edinburgh Handedness Inventory; ≥50)
* Cognitively capable (Montreal Cognitive Assessment (MoCA); ≥23)
* Mild to moderate Parkinson's disease severity (Hoehn and Yar disease stage 2-3)

Exclusion Criteria:

* History of stroke
* Comorbidity
* Cephalic implants
Anemia Correction and Fibroblast Growth Factor 23 Levels in Chronic Kidney Disease , and Renal Transplant Patient

The fibroblast growth factor-23-bone-kidney axis is part of newly discovered biological systems linking bone to other organ functions through a complex endocrine network that is integrated with the parathormone/vitamin D axis and which plays an equally important role in health and disease . Most of the known physiological function of fibroblast growth factor 23 to regulate mineral metabolism can be accounted for by actions of this hormone on the kidney.In a recent experimental study, fibroblast growth factor-23 was shown to cause pathological hypertrophy in rat cardiomyocytes by "calcineurin-nuclear factor of activated T cells" and treatment with fibroblast growth factor -blockers reduced left ventricular hypertrophy in experimental models of chronic renal failure.The current hypothesis is that, in healthy individuals, iron deficiency stimulates increased production of fibroblast growth factor23. At the same time, iron is thought to be the cofactor of enzymes taking part in the degradation of intact fibroblast growth factor-23 and thought to have a role in the excretion of degraded FGF-23 parts .Studies speculated that Angiotensin Converting Enzyme inhibitors may exert their anti-proteinuria effects at least in part by reducing serum fibroblast growth factor-23 levels although it is difficult from the results of this study to understand which comes first and brings about the other; decrease in proteinuria or fibroblast growth factor-23. Available evidence points to the deleterious effects of increased fibroblast growth factor-23 level in proteinuria, but the precise molecular mechanism still remains to be explored. An intricate and close association exists among parathormone, phosphorus, active vitamin D with FGF23, but the independent role of the latter on proteinuria is the least explored. Elaborately conducted studies that control effects of confounding factors adequately are needed to demonstrate the independent pathogenic role of FGF23.

1. To study the effect of anemia correction and left ventricular hypertrophy in Chronic Kidney Disease patients and renal transplant patients .
2. To study the relation of fibroblast growth factor and Left ventricular hypertrophy in Chronic kidney disease and renal transplant patients.
3. To study the relation between fibroblast growth factor 23 and early endothelial dysfunction in both Chronic kidney disease and renal transplant patients.

Eligibility Criteria:
Inclusion Criteria:

All patients:

1. Above 18 years old
2. Diagnosed as CKD, and renal transplanted patients at Assiut University Hospital in the period 2017-2020 .

Exclusion Criteria:

1. Severely hypocalcaemic patients \< 7mg/dl.
2. Severely hyperphosphatemic patients \>7 mg/dl .
3. Uncontrolled hypertensive patients ( more than 3 antihypertensive drugs).
4. Uncontrolled diabetic patients HBA1C \>8 .
5. Blood transfusion dependent
Associations Between Neck Muscle Fatigue, Joint Position Sense, and Headache in Cervicogenic Headache

This research study aims to better understand the relationships between neck muscle function, neck joint position sense, and headache pain and disability in people with chronic cervicogenic headache. Cervicogenic headache is headache originating from the neck area.

Participants will fill out questionnaires about their headache pain and ability to do daily activities. They will also do tests to measure neck muscle fatigue and neck joint position sense. Researchers will analyze if those with more neck muscle fatigue and poorer joint position sense have worse headache pain and disability.

The results may improve understanding of cervical spine factors related to cervicogenic headache. This could help guide more targeted treatment approaches.

Chronic cervicogenic headache (CGH) is characterized by chronic headache originating from the upper cervical spine and occipital region. CGH is associated with impairments in cervical muscular control and proprioception or joint position sense. However, relationships between these cervical impairments and headache symptoms are not fully elucidated.

This cross-sectional quantitative study aims to investigate associations between neck flexor muscle fatigue, cervical joint position sense, and clinical headache parameters like pain and disability in individuals with CGH.

A sample of 30 adults ages 18-65 years old with CGH longer than 3 months duration and more than 15 headache days per month will be recruited from neurology clinics. Participants will attend a single 2 hour study visit.

Eligibility Criteria:
Inclusion Criteria:

* Ages 18-60 years
* Chronic CGH (\>3 months duration)
* Headache frequency ≥15 days/month

Exclusion Criteria:

* Cervical nerve root compression or other specific pathologies explaining headache
* History of cervical spine surgery
* Botulinum toxin injections in cervical musculature in past 6 months
Validity of 1BPM for Diagnosis of Hypertension

Blood pressure measurement methods and conditions are determinants of hypertension diagnosis. The classical methods such as office blood pressure measurement (OBPM) and home blood pressure monitoring (HBPM) have significant limitations. A recent British guideline recommends systematic 24-hour ambulatory blood pressure monitoring (ABPM). However, these devices are not available at all health centers and they can only be used by one patient per day. The aim this study is to validate a new method, 1-hour blood pressure monitoring (1BPM), to diagnose the hypertension.

Participants with suspected hypertension will be recruited from a population of patients seen at three primary health centers in an urban area. According to the sample size estimation, a minimum sample size of 214 participants would be needed for the study. Four diagnostic tests will be performed: OBPM at three visits, HBPM, AMPM and 1BPM. The test order for the 24-hour monitoring, and 1-hour monitoring, will be set randomly. Daytime records of ABPM will be compared to all other monitoring methods using the correlation coefficients and Bland Altman plots. The Kappa index will be used to calculate degree of agreement. The sensitivity and specificity of the methods will also be calculated.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years
* To visit routinely in the health centres where the study is carried out

Exclusion Criteria:

* Severe physical or cognitive limitations
* Atrial fibrillation or other heart rhythm disorders that could interfere with readings
* Arm Circumference \> 42cm
* Arm with arteriovenous fistula
* Mental disorders
* Intolerance to the method of measurement
* Hospitalization during the study period
Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps.

This is a randomized, cross-over study. The aim of this study is to compare the post-prandial glycaemic variability after pure protein meal following with an administration of square-wave bolus of meal-insulin or without any meal-insulin bolus on the other day.

Prolonged post-prandial glycaemic variability will be identified using the self-monitoring of blood glucose (10-point curve) and CGMS.

The square-wave bolus (for meals rich in fat and/or protein) is evenly delivered over several hours as programmed by the patient. The required insulin dose will be calculated based on patient's insulin-exchange ratio. Pure protein meal will be given 3 hours after a first breakfast.

To provide the minimal impact of the previous breakfast, all patients will receive up to 120 kcal of carbohydrates and \<100 kcal from protein and fat for the first breakfast (without any extended bolus) Patients receive a standardized pure protein meal at a second breakfast time. Meal insulin will be given as a square bolus or no meal -insulin will be given at all. The 5h post-meal glucose excursions will be recorded by self-blood glucose measurements (SMBG) (every 30 minutes) and continuous glucose monitoring system (CGMS). The intervention is taking part under in-patient clinical conditions.

Eligibility Criteria:
Inclusion Criteria:

* duration of type 1 diabetes longer than 12 months
* insulin pump therapy longer than 3 months
* written informed consent by patients and parents
* insulin requirement more than 0,5 units/kg/day

Exclusion Criteria:

* diabetes related complications (e.g. nephropathy)
* chronic kidney diseases
* any disease judged by the investigator to affect the trial
* withdrawal of consent to participate in the study
Factors Associated With Hypoventilation in the Myotonic Dystrophy, Progressive Profile Over 5 Years

The aim of this study is to determine the factors associated with alveolar hypoventilation in terms of cognitive impairment, daytime sleepiness, respiratory function, nocturnal respiratory events This evaluation will clarify the clinical phenotypes of respiratory disease in myotonic steinert dystrophy.


Eligibility Criteria:
Inclusion Criteria:

* Myotonic dystrophy of Steinert genetically confirmed (number of known CTG repeats), in its classical form of adult

Exclusion Criteria:

* Inability to perform EFR assessment or polysomnography
* Moderate to severe asthma according to the GINA classification
* moderate to severe COPD (\> stage 1 of the GOLD recommendations)
* Other significant respiratory pathology
* Patient already on NIV, CPAP or under oxygen therapy
* Impossibility of receiving enlightened information
* Inability to participate in the entire study
Fluocinolone Acetonide Intravitreal Inserts in Geographic Atrophy

This study will compare the safety and efficacy of Medidur FA treatment in one eye to the sham-treated fellow eye of subjects with geographic atrophy secondary to AMD.

Each patient received a sham injection in one eye and active treatment in the other eye. The eye receiving active treatment was selected based on a randomization schedule.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis bilateral GA secondary to AMD of ≥ 0.5 and ≤ 7 MPS disc areas
* Males and non-pregnant females 55 years old or older

Exclusion Criteria:

* GA secondary to any condition other than AMD in either eye
* History of or current CNV in either eye or the need for anti-angiogenic therapy
* Glaucoma or ocular hypertension (IOP \> 21 mmHg OR concurrent therapy at screening with IOP-lowering agents) in either eye
* Treatment with intravitreal, subtenon, or periocular steroid within 6 months prior to enrollment in either eye
* Any change in systemic steroid therapy within 3 months of screening
* History of vitrectomy in either eye
* Any ocular surgery within 12 weeks of screening in either eye
14-day PCAB-based High-dose Dual Therapy and14-day PCAB-based Triple Therapy vs 14-day PPI-based Reverse Hybrid Therapy

1. Test for Helicobacter pylori. The test items include urease test, histology, bacterial culture, serology, and urea breath test. At least two positive results can be used to confirm the diagnosis.
2. To ensure that the research results are not artificially distorted, this trial is a randomized study. Random allocation (which means that the subjects will use the "random number table generated by a computer similar to the lottery" to determine the treatment group) accept one of the following schemes (1:1:1).

Helicobacter pylori (H.pylori) infect more than 50% of humans globally. This study were (1) to test whether the efficacies of 14-day PCAB-based high-dose dual therapy and 14-day PPI-based reverse hybrid therapy can achieve a higher eradication rate than 14-day PCAB-based triple therapy in the first-line treatment of H pylori infection, (2) to compare the eradication rates of 14-day PCAB-based and PPI-based bismuth quadruple therapies in the second-line treatment of H pylori infection, and (3) to examine the impacts of antibiotic resistance of H pylori as well as CYP3A4, CYP2C19 and IL-1B -511 genotypes of host on the eradication efficacies of anti-H pylori treatments.

Eligibility Criteria:
Inclusion Criteria:

Subjects infected with Helicobacter pylori.

Exclusion Criteria:

1. Those who have ever received Helicobacter pylori sterilization treatment.
2. Those who are allergic to the drugs used in this research.
3. Those who have had stomach surgery.
4. Those with severe liver cirrhosis or uremia or malignant tumors.
5. Women who are pregnant or breastfeeding.
Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based Dose

This study aimed to evaluate the effect of Neostigmine partial dose towards neuromuscular blockade of rocuronium

Approval from Ethical Committee of Faculty of Medicine University of Indonesia was acquired prior conducting the study. Subjects were given informed consent before enrolling the study and randomized into two groups. Intravenous (IV) cannula with Ringer Lactate fluid, non-invasive blood pressure monitor, electrocardiogram (ECG) and pulse-oxymetry were set on the subjects in the operation room. After preoxygenation was given with 100% oxygen, general anesthesia induction was done with midazolam 0.01-0.02 mg/kg, fentanyl 3 mcg/kg, propofol 1-2 mg/kg, and rocuronium 0.6 mg/kg. Following induction, endotracheal intubation or laryngeal mask insertion was performed. Maintenance was done by sevoflurane 1.2 vol%, and fentanyl 1.2 mcg/kg. After the surgery had finished, fentanyl drip was stopped. Subjects were then observed until spontaneous breaths occured adequately (tidal volume ≥ 5 ml/kg) before train of four (TOF) ratio was evaluated using acceleromyography (AMG). Before reversal (neostigmine) was given, anesthetic gas was stopped and duration of operation as well as post-operative TOF ratio was recorded. The time since reversal was given then recorded. Group A received neostigmine partial dose (0.02 mg) in combination with atropine 0.4 mg for every milligram of neostigmine. Group B received TOF ratio-based dose of neostigmine in combination with atropine 0.4 mg for every milligram of neostigmine. After administration of neostigmine, TOF ratio was measured every 5 minutes until TOF ratio of ≥ 90% was achieved, and finally definitive airway could be removed. For Group A, another partial dose of neostigmine was given after 10 minutes from the first reversal dose if the TOF ratio of ≥90% had not been reached. For Group B, another TOF ratio-based dose of neostigmine was given after 10 minutes from the first reversal dose if the TOF ratio of ≥90% had not been reached. Subjects were then transported to recovery room. Data was analyzed using Statistical Package for the Social Sciences (SPSS), for numerical data using unpaired T-test or Mann-Whitney-U test, for categorical data using Chi-square test or Fischer Exact's Test. Data normality was tested by Kolmogorov-Smirnov test. Significant value is p\<0.05.

Eligibility Criteria:
Inclusion Criteria:

* patients aged 18-60 years old
* American Society of Anesthesiologists (ASA) physical status I-II who were planned to undergo any elective surgery at operating room in general anesthesia
* subjects had been explained about the study, and agreed to enroll and have signed the informed consent form

Exclusion Criteria:

* BMI ≥ 30
* had any severe kidney or liver disease
* had neuromuscular disease or asthma

Drop out Criteria:

* Duration of operation less than one hour or more than 2 hours
* during surgery received maintenance dose of neuromuscular block
* intraoperative cardiac arrest was occurred
The PK/PD Study of Single Dose of SHR3824 in Healthy Volunteers

SHR3824 is a novel inhibitor of renal sodium-glucose cotransporter 2, allows an insulin-independent approach to improve type 2 diabetes hyperglycemia. In this single-dose study the investigators evaluated the safety, tolerablity and PK/PD profiles of SHR3824 in healthy subjects.


Eligibility Criteria:
Inclusion criteria:

* Chinese male and female subjects aged 18 to 45 years.
* BMI:18 -25 kg/m2 .
* Healthy according to medical history, physical examination findings, 12-lead ECG findings, and clinical laboratory evaluations.

Exclusion criteria:

* History of or current clinically significant medical illness as determined by the Investigator.
* History of clinically significant allergies, especially known hypersensitivity or intolerance to lactose.
* Pregnancy or breastfeeding .
* Significant acute or chronic medical illness, including renal impairment, or recent surgery.
* Donation of blood or plasma within the 4 weeks prior to the start of the study or acception of blood transfusion within 8 weeks.
The Effect of Kangaroo Mother Care on Breastfeeding Success in the Early Postpartum Period

The primary aim of this study was to determine the effect of kangaroo mother care on breastfeeding success in the early postpartum period. The secondary aim was to determine the effect of kangaroo mother care on the vital signs of the mother and the baby.

From the selected sample, assignments to the intervention and control groups will be made by stratified block randomization method and randomizer.org website. Since it is predicted that mothers' previous breastfeeding experiences may affect breastfeeding success, mothers will be stratified in terms of the number of births (first vaginal birth/ two vaginal births). After stratification, block randomization will be performed and mothers will be assigned to the intervention and control groups with similar characteristics.

Eligibility Criteria:
Inclusion Criteria:

* Inclusion criteria for mothers

  * Being over 18 years of age
  * Agree to participate in the survey (those who signed the Informed Consent Form)
  * Having had their first or second normal birth
  * Being literate
  * Having no communication problems
  * Being a singleton pregnancy
  * Having a gestational age of 37-42 weeks
  * Being open to communication and cooperation
  * Having an intact family unit
* Inclusion Criteria for Babies:

  * Birth weight 2500-4000 gr. between
  * Born by normal delivery
  * APGAR score of 7 and above at 1 and 5 minutes
  * No health problems or congenital anomalies
  * Born between 37 and 42 weeks of pregnancy

Exclusion Criteria:

* Exclusion Criteria for Mothers:

  * Being under 18 years of age
  * Do not agree to participate in the study
  * Not being able to read or write
  * Having more than two babies
  * Having breast problems that prevent breastfeeding
  * Being born by Caesarean section
  * Having a diagnosed mental or psychological disorder
* Exclusion Criteria for Babies:

  * Weighing less than 2500 grams
  * Weighing more than 4000 grams
  * Being born by Caesarean section
  * APGAR score of less than 7 at 1 and 5 minutes
  * Being born with a congenital anomaly
  * Born before 37 weeks
Comparison of Peri-implant Tissues Using Socket Shield Technique Versus Xenograft

The aim of this study is to clinically and radiographically evaluate the dimensional changes of soft and hard peri-implant tissues around single immediate post-extraction implants in the esthetic zone.

to compare the efficacy of the socket shield technique in counteracting the dimensional changes of the soft and hard peri-implant tissues to filliing the buccal gap with xenograft.

* Population (P): Patients with single non-restorable tooth in the esthetic zone.
* Intervention (I): Immediate implant placement with socket shield technique.
* Comparator (C): Immediate implant placement and filling the buccal gap with xenograft.
* Primary Outcome (O): Pink Esthetic Score (PES) (Fürhauser et al., 2005).
* Time frame: 9 months (Chu et al., 2015).
* Study design: Randomized controlled clinical trial.

Eligibility Criteria:
Inclusion Criteria:

1. Patient's age was 18 years or older.
2. Non-restorable tooth in the upper inter-bicuspid area.
3. Adequate bone volume for the placement of immediate implant.
4. Following tooth extraction, there was an intact socket bony wall (type I extraction socket).
5. Primary stability of the implant was achieved at the time of the implant placement.

Exclusion Criteria:

1. Patients who reported tobacco use in the past 5 years.
2. Patients who had severe periodontal destruction at the site of implant placement.
3. The presence of any signs of acute infection in the surgical site or the adjacent two natural teeth.
4. Patients who had history of any systemic disease that precludes the placement of implants.
5. Any disease that might affect bone metabolism as osteoporosis.
6. Patients taking medications that might affect bone turn over as bisphosphonates.
7. Physically or mentally handicapped patients.
8. Pregnant females.
9. Teeth with vertical root fractures on the buccal aspect
10. Teeth with any other pathologies affecting the buccal part of the root, for example, external or internal resorptions.
Association of Lunar Phases With Post-surgical Morbidity

The potential influence of lunar phases on human life has been widely discussed by the lay press. The purpose of this study was to evaluate a possible relation between the lunar cycle and the hemorrhagic complication rate and surgical outcome.

PATIENTS AND METHODS:

The investigators tested this hypothesis by evaluating the complication rate for 18760 patients who underwent surgery from January 2001 to December 2008 (103 lunar phases) at the National Institute for Cancer Research in Genoa.

The date of definitive surgery was allocated to the lunar phases.


Eligibility Criteria:
Inclusion Criteria:

* None

Exclusion Criteria:

* None