cyrilzakka/clinical-trials huggingface dataset:
Serious Game Interventions to Reduce Viral Hepatitis C Among PLWH-MSM

The study is aimed to provide high-risk, HIV-infection, men who have sex with men (MSM) with healthcare education regarding viral hepatitis C, through either serious game intervention or traditional online health education. After the education, each participants will be followed for 48 weeks and the change of risky sexual behaviors, acquisition of HCV and other STIs will be followed during the study periods.

High-risk MSM living with HIV were participated in our study will be assigned (by randomization) to either:

1. Serious game intervention: 1 single session of serious game for the participants to play (estimation to take 25-40 minutes). Hepatitis C virus (HCV)-related healthcare informations, including the severity of illness, route of transmission, preventive strategies and treatment options, would be embedded in the game.
2. Traditional online health education (reading materials): 1 single session of healthcare education regarding HCV (with similar contents) will be provided.

After the healthcare intervention, each participants will be followed for 48 weeks. Assessment of risky sexual practice (by questionnaire), test of plasma HCV RNA and serological test of syphilis (optional), and detection of sexually-transmitted bacterial pathogens (optional) will be performed at the enrollment and then every 12 weeks during the observation.

Eligibility Criteria:
Inclusion Criteria:

* High-risk MSM living with HIV, defined as:

  1. Had prior HCV infection, and had cleared HCV through treatment or spontaneously
  2. Had any STI within the past 12 months
  3. Had any unexplained elevation of liver transaminase in the past 6 months
  4. Had at least 1 unprotected anal sex during the past 6 months
* Being able to use mobile smartphone and understand study materials
* Repeat entry of study is permitted, but the interval between health education intervention should \>52 weeks.

Exclusion Criteria:

* HCV RNA positive and yet clear virus (nor reaching SVR12).
* Admission for any acute illness (including AIDS-defining conditions)
Midostaurin (PKC412) for Locally Advanced Rectal Cancer

This study combines midostaurin (PKC412) with radiation and a standard chemotherapy drug call 5-Fluorouracil (5-FU) for subjects with advanced rectal cancer. Midostaurin is a type of kinase inhibitor which works by blocking proteins associated with cancer cell growth. Previous studies also suggest that midostaurin may help increase the effectiveness of radiation therapy. In this research we are looking for the highest dose of midostaurin that can be given safely in combination with standard chemoradiation.

Midostaurin capsules will be taken by mouth for 8 weeks. For the first 2 weeks midostaurin will be taken alone (no chemoradiation). After 2 weeks standard chemoradiation will be added to the midostaurin regimen. Subjects receive midostaurin and chemoradiation for an additional 6 weeks. Physical exams will be done weekly. Blood samples will be taken and an optional tumor biopsy will be performed in week 2.

4-5 weeks after completing chemoradiation and midostaurin subjects will undergo surgery as standard of care. Tumor tissue from the surgery will be used for research purposes. A Ct scan of chest, abdomen, and pelvis will be performed.

After completion of surgery, subjects will have an end of study visit with physical exam, blood tests. CT scans of chest, abdomen, and pelvis will be performed yearly for 5 years.

Eligibility Criteria:
Inclusion Criteria:

* Adenocarcinoma of the rectum
* T3/4 or N+ disease
* Life expectancy \> 3 months
* Normal organ and marrow function

Exclusion Criteria:

* Metastatic disease
* Pregnant or breastfeeding
* Prior radiotherapy
* Receiving other investigational agents
* History of inflammatory bowel disease
* Active scleroderma or CREST syndrome
* Uncontrolled intercurrent illness
* History of a different malignancy unless disease free for at least 5 years
* HIV or active viral hepatitis
* Impaired cardiac function
OSSEODENSIFICATION BY DENSAH BURS WITH ACTIVATED PLASMA ALBUMIN GEL FOR SINUS LIFTING WITH SIMULTANEOUS IMPLANT PLACEMENT

Aim of the current study is to evaluate clinically and radiographically transcrestal sinus lifting with densah burs with the use of activated plasma albumin gel associated with simultaneous implant placement.


Eligibility Criteria:
Inclusion Criteria:

* Patient with missing maxillary premolars and molars.
* Vertical bone height of 3-5 mm.
* Good oral hygiene.
* Non smokers.

Exclusion Criteria:

* Bad oral hygiene.
* Presence of infection or periapical lesions in adjacent teeth.
* Acute maxillary sinusitis.
* Bruxism or clenching.
* Medically compromised patients with a condition that affects the procedure (patients with bone diseases such as osteogenesis imperfecta and polyarthritis and patients on radiotherapy and chemotherapy)
Resumption of Enteral Feeding After Bowel Anastomosis

Resumption of oral feeding after small intestine surgery is a matter of controversy .Some surgeons advocate early resumption while others don't.early feeding is initiated as soon as the patient recovers from effects of anaesthesia, while late resumption is started after 24-48 hours after surgery.Recent studies and guidelines suggest early feeding. The aim of this study is to compare the early and late resumption of oral feeding.


Eligibility Criteria:
Inclusion Criteria:

* All patients undergoing small bowel anastomosis for any indication in elective setting
* Patients of age between 15 to 65 years.
* All genders

Exclusion Criteria:

* Patient using glucocorticoids or other immunosuppressive drugs
* non conseting individuals
* Patient having history of gastrectomy
The Study of MicroRNA Genomics of Blood Stasis Syndrome and of Coronary Heart Disease

In this study, typical cases of blood stasis syndrome of coronary heart disease are selected, by using microRNA chip, cDNA microarray and other bioinformatics technologies to filter and verify related miRNA and its target gene of Coronary Heart disease. Meanwhile, intervene by Xuesaitong soft capsules to investigate related miRNA and its target gene of Coronary Heart disease.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of coronary angiography unstable angina
* Clinical diagnosis of unstable angina
* Age of 30 to 75 years old
* Not use thrombolysis, dilate coronary drugs within two weeks
* Tongue dark
* Sign the consent

Exclusion Criteria:

* Severe valvular heart disease
* Insulin-dependent diabetes
* mental disease
* Combined with severe liver, kidney, hematopoietic system disorder
* Patients with malignant tumors
* Pregnancy or breast-feeding women
* Recent history of trauma
* Drug allergy
Combination of Irreversible Electroporation and NK Immunotherapy for Recurrent Liver Cancer

The aim of this study is the safety and efficacy of irreversible electroporation (IRE) plus natural killer (NK) immunotherapy to recurrent liver cancer.

By enrolling patients with recurrent liver cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of the combined therapy using IRE and NK cells.

The safety will be evaluated by statistics of adverse reactions. The efficacy will be evaluated according to local relief degree, progress free survival (PFS) and overall survival (OS).

Eligibility Criteria:
Inclusion Criteria:

* All standard therapies have failed according to NCCN guidelines or the patient refuses standard therapies after cancer recurrence
* Body tumor 1-6, the maximum tumor length \< 5 cm
* KPS ≥ 70, lifespan \> 6 months
* Platelet count ≥ 80×109/L，white blood cell count ≥ 3×109/L, neutrophil count ≥ 2×109/L, hemoglobin ≥ 80 g/L

Exclusion Criteria:

* Patients with cardiac pacemaker
* Patients with brain metastasis
* Patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction
IBSR Meditation Technique for Teachers' Burnout

The purpose of this study is to investigate the effect of Inquiry based stress reduction (IBSR) meditation technique on levels of burnout and wellbeing among teachers.

Teachers' burnout is a well-known phenomenon with personal and professional implications. The current study investigates the effect of inquiry based stress reduction (IBSR) technique on burnout and well-being among teachers.

Eligibility Criteria:
Inclusion Criteria:

* All the teachers working in 'Begin' high-school, Rosh Hayin, Israel
* agreed to sign an informed consent form

Exclusion Criteria:

* Teachers with previous experience with IBSR technique
The Relationship Between Upper Extremity Functionality, Trunk Control and Balance in Children With Cerebral Palsy

The aim of this study is to examine the relationship between trunk control, upper extremity functionality and balance in children with cerebral palsy and to compare this relationship with healthy sedentary children.This study is carried out through Eastern Mediterranean University Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Pediatric Rehabilitation Unit.

23 children with Cerebral Palsy and 30 healthy children will be included in the study, and the families of all children participating in the study will sign an informed consent form.After signing the consent form from the families of the children included in the study, their demographic information will be recorded and their Gross Motor Function Classification System levels will be determined.

Children's upper extremity functionality will be evaluated with the Quality of Upper Extremity Skills Test. To determine their functional balance, the Single-Leg Stance Test and the Four Step Square Test are measured. Additionally, balances will be determined by the Trunk Control Measurement Scale. Evaluations are made using tables and chairs. Evaluations take approximately 60 minutes, depending on the condition of the children, and all evaluations will be made one-on-one by the physiotherapist. In the study where power analysis was performed, 50 child evaluations were deemed appropriate. Statistical Package for the Social Sciences package program is used to analyze the data. Whether the data complies with normal distribution will be evaluated using the Shapiro Wilk Test and histogram graphs. Descriptive statistics are given as mean, standard deviation, median, number and percentage. Numerical data between groups are compared using Student's t test and Mann Whitney U test. Categorical data will be compared using the Chi Square test. Spearman's correlation test was used for correlation analysis, p value \<0.05 will be considered statistically significant.

Eligibility Criteria:
Inclusion Criteria:

* Between the ages of 8-18,
* Gross Motor Function Classification System level 1-2,
* Do not have severe visual or hearing impairment,
* Does not have any cooperation problems that would hinder communication,
* Children who have had Botulinum Toxin-A injection

Exclusion Criteria:

* Those with GMFC level 3-4-5,
* Children who had surgery within the last six months were not included in the study.
Observational Post-Authorisation Study on the Use of Bemfola® in Human Assisted Reproductive Techniques in Spain.

Non-comparative, observational, ambispective post-authorisation study (EPA-SP).


Eligibility Criteria:
Inclusion Criteria:

* Women aged ≥ 18 years
* Currently undergoing an IVF or ICSI cycle or are oocyte-donors
* Have completed controlled ovarian stimulation
* Have received at least 5 doses of Bemfola®
* Are pituitary suppressed with a GnRH antagonist
* Have undergone oocyte retrieval
* Have signed the Informed Consent Form

Exclusion Criteria:

* Hypersensitivity to the active substance follitropin alfa, FSH or to any of the excipients listed
* Presence of tumours of the hypothalamus or pituitary gland
EEG@HOME (Phase 3a of the Project, Comparison of EEG-recordings)

The goal of this project is the development of an EEG-cap (min. 21 electrodes) with user-friendly active dry electrodes that meets the expectations of the users regarding comfort and esthetics, without losing sight of the functional and technical demands for recording high quality EEG signals. The purpose is to use the EEG-cap to investigate clinical neurological disorders (e.g. epilepsy). The EEG-cap could also be used at home so that hospital admission in the EMU can be avoided for some patients and an increasing number of patients can be examined.

Phase 3 of the Project will be divided into a Phase 3a and Phase 3b.

Phase 3a of the project will comprise of an EEG-registration with the different types of electrodes in epilepsy patients with prominent interictal epileptiform discharges (IEDs) on EEG. For each epilepsy patient the EEG-recording with dry electrodes will be compared to the EEG-recordings with conventionally used wet electrodes (bridge and cup electrodes). Each EEG-recording will take approximately 10 minutes.

Minimum 2 - maximum 10 epilepsy patients will be included.

There will be an visual and clinical evaluation of the EEG-signals (blinded) and a technical evaluation of the EEG-signals. User experience will also be collected.


Eligibility Criteria:
Inclusion Criteria:

* Epilepsy patients with prominent interictal epileptiform discharges (IEDs) on EEG

Exclusion Criteria:

* Epilepsy patients with no prominent interictal epileptiform discharges (IEDs) on EEG
Evidence-based Intervention for Improved Head Impact Safety in Youth Football - Aim 1 and Aim 3

Two middle school (ages 11-14) football teams will be in Aim 1 of this study. All interested athletes on these teams will be invited to voluntarily participate in biomechanical data collection; of those enrolled, 15-20 per team will be randomly selected for instrumentation with head impact sensors. In aim 3, two youth football teams at the middle school level will be recruited to pilot an intervention developed this study. The football coaches of each team will be prospectively recruited and enrolled. All interested athletes on these teams will be enrolled; of those enrolled, 15-20 per team will be randomly selected for instrumentation with head impact sensors. Baseline and post-season neurocognitive data will be collected.

This study hypothesizes that (a) determinants at the individual (athlete), interpersonal (team \& coach), and community levels (built \& social environment) of the social ecological model may be identified and targeted to reduce head impact exposure in youth football practices, and (b) an evidence-based strategy to reduce head impact exposure in practices may be developed and pilot tested using a community-engaged approach.

Eligibility Criteria:
Inclusion Criteria:

* All athletes participating on the prospective teams will be eligible for the study, including those with braces longer than 6 months.

Exclusion Criteria:

* Athletes will be excluded from participation if they have had braces less than 6 months, or have dental appliances that may impede the fit of the mouthpiece device (e.g., Herbst Appliance).
Dose Response Trial of Pergolide for Cocaine Dependence - 1

The purpose of this study is to evaluate the efficacy and safety of pergolide for treatment of cocaine dependence.


Eligibility Criteria:
Please contact site for information.
Long Endotracheal Tube vs. Aintree Intubating Catheter for Fiberoptic-guided Intubation in Manikin

In difficult airway situation, fiberoptic-guided endotracheal intubation through laryngeal mask airway(LMA) is one of option. Aintree catheter is a device to help change LMA to endotracheal tube, but it needs complex and multiple process. Long endotracheal tube can solve this problem of Aintree catheter. The purpose of this study is proving the efficacy of long endotracheal tube compared to Aintree cathter in fiberoptic-guided intubation through LMA.

In difficult aiway situation, fiberoptic-guided endotracheal intubation through laryngeal mask airway(LMA) is one of option according to Difficult intubation guidelines. First, insert LMA and insert fiberoptic through LMA. Second, insert endotracheal tube using fiberoptic as a guide. This process has several problem. Removal of LMA is impossible, so there is a risk of dislodging of endotracheal tube.

Aintree catheter is developed to this problem. Insert Aintree catheter through LMA using fiberoptic, and remove LMA, finally insert endotracheal tube throug Aintree catheter. But the problem of this method is that the whole process is complex and takes long time. And there is a risk of impeding of endotracheal tube at glottis level because the difference of diameters between endotracheal tube and aintree catheter.

Long endotracheal tube could solve the problems mentioned above. Through LMA, insert endotracheal tube using fiberoptic as a guide. Tube is long enough to remove LMA without a risk of dislodging. And after removal of LMA, tube can be cut for optimizing length.

So the purpose of this study is comparing the efficacy of Aintree catheter method and Long tube method in manikin.

Eligibility Criteria:
Inclusion Criteria:

* Residents of Anesthesiology
* Who has less than 10 times of experience of fiberoptic intubation

Exclusion Criteria:

* Who has more than 10 times of experience of fiberoptic intubation
* Who deny participating in the study
Resistance Rates and Mechanisms of Resistance to Imipenem and Meropenem at UPMC

The isolate samples will be collected over a period of one year once IRB approval has been obtained. These isolates were collected as part of the patient's clinical care and once all clinical testing is complete, all isolates will be discarded. The honest broker of our area will collect the isolates and deidentify all information once all clinical testing is complete. The isolates will be obtained from the microbiology lab.

The study will collect two hundred pseudomonas and 20 acinetobacter baumanti consecutive bacterial isolates from microbiology. These isolates are collected as part of the patient's clinical care and are discarded once all clinical testing is complete. The honest broker will obtain these samples after all clinical testing is complete. All isolates will be deidentified. These isolates will be tested using standardized susceptibility methods for meropenem and imipenem. The activity of doripenem, a carbapenem currently being studied, and arbekacin an aminoglycoside, will also be tested. The honest broker will also collect limited patient data including underlying condition, presence of a solid organ transplant, ward location, and antibiotic history over the three months prior to organism isolation. For resistant isolates found, analytical and molecular techniques will be performed to determine the mechanisms of resistance and whether resistant isolates are coming from a single source/being transmitted from person to person.

Eligibility Criteria:
Inclusion Criteria:

* Samples" for the purpose of this study are Gram negative bacteria in a Petri dish of growth media.
Study In Patients With Overactive Bladder Treated With Toviaz® After Failure Of Previous Therapy

This is a observational study in patients treated with fesoterodine (Toviaz), who have failed on previous treatment for overactive bladder. It will collect epidemiological data and investigate the efficacy and tolerability of fesoterodine.

patients older than 18 years with overactive bladder after failure of previous antimuscarinic therapy (due to lack of efficacy or intolerance)

Eligibility Criteria:
Inclusion Criteria:

* Patients older than 18 years
* Patients with OAB after failure of previous antimuscarinic therapy - due to lack of efficacy: persistence of storage symptoms.
* Required symptoms: micturition frequency 8 and more / 24 hours and urgency episodes ≥2 per day subjectively perceived as bothersome
* Due to intolerance: persistent and/or unacceptable adverse events

Exclusion Criteria:

* Hypersensitivity to the active substance or to peanut or soya or any of the excipients.
* History of acute urinary retention (requiring catheterisation)
* Gastric retention
* Uncontrolled narrow angle glaucoma
* Myasthenia gravis
* Severe hepatic impairment (Child Pugh C)
* Concomitant use of potent CYP3A4 inhibitors in subjects with moderate to severe hepatic or renal impairment
* Severe ulcerative colitis
* Toxic megacolon.
Can Novel Oxygenation Indices Guide the Diagnosis of Acute Respiratory Distress Syndrome

This study aims to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.

Recent studies have shown that mechanical power (MP) values below 17 J/min and driving pressure (DP) values below 15 cmH2O reduce intensive care unit (ICU) mortality. Asar et al. have introduced six new oxygenation indices utilizing MP and DP instead of Pmean (OSI-MPtot, OI-MPtot, OSI-ΔPinsp, OI-ΔPinsp, OSI-MPdyn, OI-MPdyn). They compared the predictive abilities of these new indices for ICU mortality in Covid-ARDS (C-ARDS) patients with conventional oxygenation indices (P/F, SpO2/FiO2, OI, OSI, PaO2/(FiO2xPEEP), and SpO2/FiO2xPEEP). OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices exhibited the highest predictive power for ICU mortality. However, cut-off values for the diagnosis and severity determination (mild, moderate, and severe) of ARDS patients have not been investigated.

In this study, our objective is to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.

Eligibility Criteria:
Inclusion Criteria:

1. Patients admitted to intensive care units diagnosed with ARDS / C-ARDS according to the Berlin criteria.
2. Adult patients aged between 18 and 80 years

Exclusion Criteria:

1. Patients under the age of 18
2. Pregnant patients
3. Patients without ARDS
4. Patients with missing data
5. Patients transferred to another hospital
6. Patients discharged from the ICU within 72 hours
7. Patients receiving extracorporeal membrane oxygenation (ECMO) support.
8. Patients were on mechanical ventilation for less than 24 hours
Drug-drug Interaction Study of Ruzasvir and Bemnifosbuvir

Drug-drug interaction study of Ruzasvir and Bemnifosbuvir


Eligibility Criteria:
Inclusion Criteria:

* Must agree to use two methods of birth control from Screening through 90 days after administration of the last dose of study drug.
* Minimum body weight of 50 kg and body mass index (BMI) of 18-29 kg/m2.
* Willing to comply with the study requirements and to provide written informed consent.

Exclusion Criteria:

* Infected with hepatitis B virus, hepatitis C virus, HIV or SARS-CoV-2.
* Abuse of alcohol or drugs.
* Use of other investigational drugs within 28 days of dosing.
* Concomitant use of prescription medications, or systemic over-the-counter medications.
* Other clinically significant medical conditions or laboratory abnormalities.
Lymphoma and T Helper 2 Cytokines Relationship With Prognostic Markers

The investigators hypothesized that Non Hodgkin lymphoma is using T helper 2 pathways. So that the investigators decided to study of cytokines related to T helper 2 pathways. It is well known that parasites and allergic situations also use T helper 2 pathways. Because that the investigators excluded the patients have parasites and allergic situations. All the patients were over 18. The investigators included the patients with non Hodgkin lymphoma which new diagnosed. It is observational study. The investigators took blood before chemotherapy and four months later. The investigators did not interfere with which chemotherapy will be given to patients. This decision was belong to hematologist or oncologist who will treat the patient.


Eligibility Criteria:
Inclusion Criteria:

* newly diagnosed non hodgkin lymphoma
* Diffuse large B cell lymphoma and T cell lymphoma patients

Exclusion Criteria:

* under 18 age
* parasitosis
* allergic status