cyrilzakka/clinical-trials huggingface dataset:
The Individualized Behavioral Intervention of Smartphone App in the Treatment of Type 2 Diabetes Mellitus

The patients with type 2 diabetes who underwent routine hypoglycemic agents and insulin therapy were evaluated for 48 weeks with maltose software.

This study enrolled 400 patients with type 2 diabetes in five centers in Shandong Province, China. Patients with type 2 diabetes who met the inclusion / exclusion criteria were randomly assigned to the trial group (conventional treatment + maltose app) or the control group (conventional treatment) in a 1: 1 ratio.

The control group: given conventional hypoglycemic drug treatment, the treatment plan by the investigators according to the patient's condition may be, this study does not interfere.

The trial group: the patients were treated with conventional hypoglycemic drugs. The treatment plan was decided by the researcher according to the patient's condition. The intervention was not done in this study.

Interventions include:

1. Weekly diabetes-related science articles.
2. Patients reported hypoglycemia or other adverse reactions, the competent physician to deal with.
3. Questionnaires published out the hospital (2 weeks 1), the feedback for the problem.
4. monitoring of abnormal blood glucose data or the presence of related discomfort, can communicate with the competent physician online.
5. Personalize the development of diet, exercise program.
6. different insulin and oral hypoglycemic drug medication time to remind.
7. hypoglycemic drug side effects query.

Eligibility Criteria:
Inclusion Criteria:

1. Male and female patients diagnosed with type 2 diabetes, age ≥ 18 years and ≤ 65 years;
2. diagnosis of type 2 diabetes ≥6 months;
3. The patient signed an informed consent form and agreed to collect the data. The trial group agreed to apply the maltose app during the trial period to study popular science articles, to receive software reminders and to answer questions regularly;
4. HbA1c≥7.0% in the last one (≤3 months) before enrollment;
5. be able to use Mobile App;
6. The mobile phone used by the patient must support maltose App installation.
7. Receiving regular diabetes education in the hospital.

Exclusion Criteria:

1. Has participated in any randomized controlled clinical study;
2. To long-term use of insulin pump as the main treatment of type 2 diabetes;
3. patients with type 1 diabetes;
4. pregnant or lactating women;
5. doctor, alcohol, drug abuse, schizophrenia, severe vision and hearing impaired;
6. Can not accept software manager;
7. Other investigators considered it inappropriate to participate in the study.
The Impact of Arabic Gamified Mobile Application on Diabetes Control in Egyptian Pediatric Patients With Type 1 Diabetes.

This is a prospective randomized parallel two group pharmacist-led interventional study. The study will involve introduction of the mobile game to pediatric diabetic patients to improve their blood glucose level. The outcomes to be measured are diabetes control and behavioral change in pediatric patients with type1 diabetes mellitus


Eligibility Criteria:
Inclusion Criteria:

1. Pediatric patients age from 7 to 14 years old to be able to deal with and understand the game.
2. Children previously diagnosed with type1 DM.
3. Arabic speaker.
4. Smart phone (android) access at home, either the mobile of the child or his/her parents.

Exclusion Criteria:

1. Severe cognitive or psychiatric conditions that prevent a patient from understanding the game. any disorder that significantly impairs the cognitive function of an individual to the point where normal functioning in society is impossible without treatment ,examples: dementia- developmental disorders-motor skills disorders- amnesia- substance induced cognitive impairment)25
2. Diabetic pediatric patients at goal with HbA1c \< 7.
Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes. Perfusion measurement has been shown to improve sensitivity and predictive value for tumor grading and prognosis, also as a predicator of recovery with reperfusion in patients of acute ischemic stroke.Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Eligibility Criteria:
Inclusion Criteria:

* no hypertension or cerebral vascular diseases,
* no systemic metabolic disease;
* no infection or fever;
* no use of corticosteroid drugs;
* no MRI contraindication.

Exclusion Criteria:
Evaluation of the Cell Detachment Ratio on pH-responsive Chitosan as a Prognostic Factor in Lung Cancer

Biomaterial-based cell culture models have been gaining increasing attention as potential therapeutic strategies. The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients. Through controllable cell-material interaction, this project has the intention to develop an alternative tool for both early diagnosis and accurate prognosis in cancer therapeutics.


Eligibility Criteria:
Inclusion Criteria:

* Lung cancer patient between 20-70 years old who need surgery for the resection of lung lesions.
* Willing to sign the consent form under the informed consent.

Exclusion Criteria:

* Vulnerable subjects included minors, prisoners, aborigines, pregnant women, people with mental disorders, students, and subordinates, etc.
Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery

Caudal block is often performed to relieve postoperative pain in pediatric urological surgery. Recently, pudendal block is also used in penile surgery and it has advantage because of less side effects such as transient weakness of low extremities, but limited to use in penile surgery. Local anesthesia is a single shot injection, so additional analgesic drugs is required when the effect of local anesthetics are disappeared. Dexmedetomidine, an alpha adrenergic agonist, is commonly used in pediatric sedation. It has analgesic effect and potentiates the effect of local anesthetics. There are many studies about the potentiation of the effect of local anesthetics when added to dexmedetomidine in adults, it has been limited in pediatrics. Recent study said that local anesthetics with dexmedetomidine had prolonged duration of analgesia in caudal block, also in ilioinguinal block. Thus it is expected to have a prolonged effect when investigators use dexmedetomidine in pediatrics as well as adults.


Eligibility Criteria:
Inclusion Criteria:

1. The patients aged between 6 months and 6 years in elective penile surgeries (hypospadias, urethral fistula or stricture after hypospadias repair, penile curvature)
2. American Society of Anesthesiologists (ASA) class I, II

Exclusion Criteria:

1. Coagulopathy
2. allergy to local anesthetics
3. meatal island onlay proximal transverse island flap (MIOPTI) (more than 4 h for the surgery)
4. illiteracy, foreigner
The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy

The purpose of the trail is to evaluate the efficacy and safety of PEG-rhG-CSF in primary prophylaxis and secondary prophylaxis of neutropenia after chemotherapy.


Eligibility Criteria:
Inclusion Criteria:

1. Patients with age between 18 and 70 years.
2. Breast cancer, lymphoma, bone tumor or Gynecologic tumor patients.
3. With multi-cycle chemotherapy.
4. With III/IV degree neutropenia after the last cycle of chemotherapy and plans to use the same regimen in the subsequent cycles.FN risk of the chemotherapy regimens is ≥20%，or 10%≤FN risk\<20% and has high risk factors associated with FN.
5. KPS score≥ 70.
6. Expected to survive more than 3 months.
7. No hematologic system disease and ANC≥1.5×10E9/L, PKT≥80×10E9/L, Hb≥ 75g/L, WBC≥3×10E9/L, and no bleeding tendency.
8. Written informed consent are acquired. -

Exclusion Criteria:

1. With infection or systemic antibiotic therapy 72h before chemotherapy.
2. With any abnormal hematopoietic function.
3. Received transplantation within 3 months.
4. Suffered from other malignant tumor or brain metastases.
5. TBIL, ALT,AST \> 2.5×ULN; if it were caused by liver metastases, TBIL, ALT,AST \>5×ULN.
6. Cr \>1.5 ×ULN.
7. Sensitive to the product or other genetically engineered biological products from Escherichia coli strains.
8. Mental or nervous system disorders.
9. Refused to accept contraceptive measures.
10. Other situations that investigators consider as contra-indication for this study.

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Effect of Platelet-rich Fibrin on Rotator Cuff Repair

The objective of this study was to prospectively evaluate the influence of local application of Platelet Rich Fibrin (PRF) on the functional outcome and integrity of the arthroscopically repaired tendons in patients with massive tears of the rotator cuff.

A prospective, randomized clinical trial was performed on 28 patients (22 females, 6 males) with an average age of 65 years (range, 53 to 77) undergoing complete arthroscopic repair of a massive rotator cuff tear. In 14 patients, after the repair was completed, 6 cc. of PRF (vivostat ®) were locally applied to the repair site. In 14 patients no addition of PRF was performed. All patients underwent an arthro-MRI to evaluate the integrity of the repair and a clinical exam one year after the operation. All patients were then followed clinically at a minimum of 2 years. Functional outcome was evaluated with the Constant and DASH scores.

Eligibility Criteria:
Inclusion Criteria:

* Massive rotator cuff tears affecting supraspinatus and infraspinatus
* Failed conservative treatment for at least 6 months
* No hematologic disorder

Exclusion Criteria:

* Rotator cuff affecting subscapularis
* chronic infectious disease
* anemia
* clot disorders
* low platelet count
* history of difficulty in venous puncture
Multiple Doses of Anti-NOGO A in Relapsing Forms of Multiple Sclerosis

This study will investigate an experimental new drug, GSK1223249 in patients diagnosed with relapsing forms of multiple sclerosis. The study will specifically investigate safety (vital signs like heart rate, blood pressure, Magnetic Resonance Imaging (MRI), and other markers of health from blood samples), tolerability (any side effects that occur, if any), and pharmacokinetics (how the body processes the drug and how long the drug stays in the blood, and in cerebro-spinal fluid). The study will also investigate if patients' own immune system interacts with GSK1223249.

This study will be a randomised, placebo-controlled, single-blind (Investigator and Subject), single and repeat ascending dose protocol, in multiple sclerosis patients. The study is designed to evaluate the safety, tolerability, pharmacokinetics, and any potential for immunogenicity of GSK1223249 (a monoclonal antibody raised against Nogo-A), given intravenously in Multiple Sclerosis patients. The study will also evaluate exploratory endpoints including para-clinical activity via magnetic resonance imaging, cerebrospinal fluid pharmacokinetics, and effect of repeat dose administration of GSK1223249 on disability. Furthermore MS symptoms, such as relapses and individual symptom severity will be closely monitored.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with a relapsing form of MS .
* Using one of the following ongoing MS treatment strategies, defined as

  1. Currently receiving Beta-interferon/Copaxone for treatment of MS and have been receiving the current course of therapy for 3 or more months prior to screening, OR
  2. Not currently receiving disease modifying therapies for treatment of MS, and has not received such therapies for at least 3 months prior to screening.
* Demonstrated clinical activity in 2 years prior to screening, whilst receiving current/previous treatment regimen or prior to any treatment regimen
* Expanded Disability Status Scale (EDSS) score ≤6.0 at either the screening or baseline visit.
* Male or female between 18 and 60 years of age inclusive, at the time of signing the informed consent.
* Body weight equal to or greater than: 50 kilogrammes

Exclusion Criteria:

* Complications/History of other diseases that may impact on safety of patients enroling into the study.
* Liver function test outside normal range for patient population
* Treatment with methylprednisolone or any other systemic steroid, for a relapse or otherwise, within 30 days of screening
* Treatment in the past 6 months with any of the following agents: Fingolimod (Gilenya), methotrexate, mitoxantrone, azathioprine, or other small molecule immunosuppressants.
* History of anaphilaxis to protein based therapeutics or mono-clonal antibodies.
* Positive result for Hapatitis B, HIV, and/or drugs of abuse, or excessive alcohol consumption.
* Not able to undergo MRI scanning safely, or Gadolinium (contrast enhancing agents) during MRI.
* Other significant infections e.g. Tuberculosis.
Early Neurodivergent Developmental Trajectories in Autism and in Response to the ESDM Intervention

Early support is thought to be key to ensure a better quality of life for young children on the autism spectrum. Among early support, different evidence-based approaches have combined the principles of developmental and behavioral science within a naturalistic and interactive frame and grouped under the umbrella of Naturalistic Developmental Behavioral Interventions (NDBI). In the context of NDBIs, the Early Start Denver Model is a manualized support that has reported evidence of efficacy for therapist-, group- and caregiver-implemented support, in multiple research as well as community based settings, different countries and languages (Rogers \& Dawson, 2010). Understanding the effects of support characteristics and intensity on individual learning has a major impact on the delivery systems organization and policies, sustainability in low resources community settings and to provide the necessary support to the family. However, a direct comparison among different types and intensity of early support in community setting and relatively low access to standardized and intensive programs, have not been adequately explored. For this reason, the aim of this study is to investigate, in a community setting in the Italian context, the impact of ESDM and support intensity on individual developmental trajectories.


Eligibility Criteria:
Inclusion Criteria:

* unimpaired hand use
* parent agreement to have a caregiver present during all home sessions
* attendance at all intake sessions
* permission to videotape evaluations and ESDM treatment
* Italian as one primary language of the parent
* unimpaired hearing and vision
* developmental quotient of 35 or higher on the Griffith Scale
* meets all of these autism spectrum disorder diagnostic criteria through the Autism Diagnostic Observation Schedule (ADOS; cutoff score of 12 if child produces no words or 10 if child produces some words)

Exclusion Criteria:

* serious parental substance abuse
* parental self-report of bipolar disorder or psychosis
* known genetic syndromes
* serious medical conditions (e.g., encephalitis, concussion, seizure disorder)
* significant sensory impairment
* birth weight \<1600 grams and/or gestational age \< 34 weeks
* history of intraventricular hemorrhage
* known exposure to neurotoxins (including alcohol, drugs)
* non-Italian-speaking parents
After Cancer in the Military: What Happens After Long-term Sick Leave

In recent decades, early diagnosis and improved treatment have led to increased survival for most people with cancer. This improved survival has led to more attention being paid to the quality of life of these people, and to their reintegration into social and professional life. In France, 3.8 million people are treated or in remission from cancer in 2017. Among the 400,000 new patients diagnosed with cancer each year in France, 160,000 (40%) are in professional activity.

Cancer treatments induce after-effects that can be felt several months or even years after the diagnosis and have an impact on life. In a study of patients in remission from cancer at 12 months after diagnosis, 47 to 53% of patients had changed jobs or stopped working. In another Finnish study, 26% of patients had decreased physical ability and 19% had decreased mental ability to work five years after cancer diagnosis.

In France, studies that have evaluated the impact of cancer on employment and the factors associated with return to work after cancer are still rare: the VICAN study showed that among people in work at the time of diagnosis, 20% were no longer working five years later.

With an estimated annual incidence of approximately 400 new cancers per year, the military population is also affected by cancer. Professional reintegration after cancer is of particular concern to the military. The specificity and requirements of the military condition can indeed make this reintegration more difficult. Regular or even intense physical activity is indeed essential but can be difficult after undergoing anti-cancer treatments. Moreover, external operations and many activities are conditioned by the obtaining of medical skills, which are sometimes incompatible with the state of health of patients recently treated for a neoplastic pathology. The studies previously carried out concerning the professional future after cancer do not seem to us to be transposable to the military population. To our knowledge, no study has evaluated occupational reintegration in military personnel after cancer.

The aim of this study is to evaluate the difficulties encountered during the post-cancer professional reintegration of military personnel in terms of fatigue, aptitude and advancement, in order to anticipate them and possibly remedy them. The identification of these difficulties will eventually allow to anticipate them and possibly to remedy them via an adapted post-cancer professional reintegration pathway.


Eligibility Criteria:
Inclusion Criteria:

* French military personnel who were placed on long-term sick leave for the management of a tumor pathology between January 2015 and December 2020,
* French-speaking.

Exclusion Criteria:

* Under 18 years old
Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and heat evoked brain signaling using a quantitative sensory testing device. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.


Eligibility Criteria:
Inclusion Criteria:

* Healthy volunteers, all ethnicities, who understand and speak English.

Exclusion Criteria:

Claustrophobia (scanning environment may be uncomfortable). Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.

Contraindications to CT: pregnancy Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's) History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor) History of head injury resulting in loss of consciousness for \>10 minutes. History of alcohol or drug dependence (through self-report).
Coping, Perceived Meaning, Joy, Horizontal Civility At Work

The aim of this study is to assess and describe employee characteristics associated with perceived horizontal inter-collegial workplace uncivil behavior within nursing services, and identify any relationships with meaning and joy in work (MJW), and assess job satisfaction.

Workplace incivility in the nursing profession interferes with the establishment of a culture of safety, places patient safety at risk, and erodes job satisfaction and a positive staff environment (Kile, Eaton, deValpine, \& Gilbert, 2019). Contemporary research among nurses in Magnet and Pathway to Excellence-designated hospitals reflects that 'nurse coworker incivility is sporadic on average but varies considerably across nurses (Smith, Morin, \& Lake, 2018). However, there needs to be more administrative focus and attention on nurses' work environments to support civil workplaces where the nurses focuses on and provide patient care (Smith et al., 2018). Hence, the proposed study aims to examine intra-organizational incivility, that is incivility 'originating from within the organization' (Cortina, Magley, Williams, \& Langhout, 2001), and will examine nurses' intrapersonal resourcefulness to support or promote proactive self-management in a self-efficacious manner, thus ameliorating workplace incivility, dissatisfaction, and detrimental outcomes. For this study, nursing staff will include registered nurses and other para-professionals employed under nursing services. The para-professionals employed under nursing services are Mental Health Technicians (MHT), Patient Care Technicians (PCT), Surgical Technicians (ST), and Emergency Medical Services (EMS).

Eligibility Criteria:
Inclusion Criteria:

* The sample of participants will include all willing individuals who are registered nurses (full time, part time, and per-diem) or nursing para-professionals employed by MHS and working at the MDMC, MCMC, MLMC, or MMMC campuses.
* Provide direct patient care for more than 50% of work hours.
* All participants must be able to read and understand English.

Exclusion Criteria:

* Excluded from the study will be employees who do not provide direct patient care for at least 50% of the time, educators, managers, leaders, advanced practice nurses, and non-nursing service personnel.