cyrilzakka/clinical-trials huggingface dataset:
Treatment Result of Zirconia Laminate Veneer

This study aims to evaluate the clinical performance of the zirconia laminate veneer, a minimally invasive prosthetic restoration

Patients with indications for single tooth restoration with ceramic laminate veneers are recruited for the study. These indications include spaced, discolored, malformed, root canal-treated, chipped, and mildly crowded teeth. After providing written informed consent, all patients are randomly divided into two groups in a double-blind manner (participants and the outcomes assessor) in a 1:1 ratio, including the Zirconia group (intervention) and the Lithium Disilicate group (control). Each patient's tooth is prepared and restored with the corresponding laminate veneer material, that is, zirconia and lithium disilicate.

Eligibility Criteria:
Inclusion Criteria:

* Spaced tooth
* Discolored tooth
* Malformed tooth
* Root canal-treated tooth
* Chipped tooth
* Mildly crowded tooth

Exclusion Criteria:

* Tooth bruxism
* Inadequate enamel for bonding
* Large restoration exists
* Bad oral habits harming restoration
Clinical Evaluator Outcomes Reliability Study

This study outlines structured Clinical Evaluator (CE) testing techniques that are proposed to be implemented across all sites participating in the Cooperative International Neuromuscular Research Group (CINRG) research studies. The study will determine if the selected techniques are reliable and reproducible across the CINRG network by evaluating the reliability and reproducibility of the measures between CEs


Eligibility Criteria:
Dystrophinopathy Participant Inclusion Criteria:

* Site confirmed genetic diagnosis of a dystrophinopathy
* Aged 6 years and older
* Able to transfer to testing table
* Able to walk 10 meters without an assistive device

Dystrophinopathy Participant Exclusion Criteria:

* Investigator assessment of inability to comply with protocol assessments
* Participants who have attention deficient disorder or other cognitive conditions that may limit attention span to perform protocol assessments
Human Papillomavirus in Cervical Cancer and Pre-cancer in Switzerland: The CIN3+Plus Study

This study will investigate the types of HPV in samples from women with cervical pre-cancer and cancer and gather information to help investigate the impact of HPV vaccination in Switzerland.


Eligibility Criteria:
Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Participant is literate in German, French, Italian or English.
* Female, aged 18 years or above.
* Histologically confirmed CIN3+ lesions, i.e. CIN3, adenocarcinoma in situ and invasive carcinoma of the cervix.
* Participant resides in the canton Zurich, Geneva, Basel, Baselland, Luzern or Ticino.

Exclusion Criteria:

* None
Chinese Herbal Medicine for Dialysis-related Myofascial Pain: Study Protocol for A Pilot Randomized Study

Dialysis-related myofascial pain in hemodialysis (HD) patients is an important issue that is associated with many other psychosomatic problems. Effective interventions are required to alleviate pain problems in this group. Chinese herbal medicine (CHM) has been tried as a potential therapeutic method to improve pain. The aim of this study is to evaluate the effect of a CHM formula intervention on pain intensity, daily function, and quality of life, and safety among HD patients in dialysis center within a southern Taiwan context.


Eligibility Criteria:
Inclusion Criteria:

* Adults (aged ≥ 20 y) undergoing conventional HD three times a week via an AV fistula;
* To have myofascial trigger points (MTrPs) in one or more of the following muscles around the AV fistula: the flexor carpi radialis, palmaris longus, the pronator teres, the palmaris longus, and/or the finger flexor, diagnosed by dialysis-related myofascial pain, which must be experiencing pain during HD \[M1\];
* Onset of symptoms within 1 month before enrollment;
* Capable of giving adequate response to pain;
* Have an exquisite tenderness was found on palpation in the taut band with moderate intensity of pain at baseline (ie, a pain score \> 3 on a numeric rating scale);
* Can commit to not change their medication and dialytic method during the 10 weeks of this study.

Exclusion Criteria:

* Severe chronic or acute disease interfering with attendance for therapy;
* Have comorbid conditions such as rheumatoid arthritis, stroke, tumor, coagulopathy, chronic liver disease, radiculopathies of the upper limb, recent history of cervical/shoulder/arm surgery, or trauma;
* Have depression and/or presence of a psychiatric disorder;
* Have taken painkillers, muscle relaxant, and anti-inflammatory medications or used topical anesthetics in the past week;
* Have allergy to Chinese herbal product;
* Unable to understand or sign an informed consent form.
Influence of Relaxing Breathing Before Each Station of an Objective Structured Clinical Examination

SObjective and Structured Clinical Examinations (OSCEs) has been incorporated recently in the certification process as a final national undergraduate ranking examination. This exam is an additional major stressor for medical students.

The aim of this study was to compare the efficiency on stress reduction of a standardized relaxing breathing occuring during rotation of the OSCE stations just before the start of the next upcoming OSCE station, in medical student, during the OSCE.

Stress generated during the curriculum might have deleterious effects on the wellbeing and the health of medical students. Objective and Structured Clinical Examinations (OSCEs) has been incorporated recently in the certification process as a final national undergraduate ranking examination. This exam is an additional major stressor for medical students.

Stress coping strategies could be implemented to help them better prepare for this examination. The aim of this study was to compare the efficiency on stress reduction of a standardized relaxing breathing as a coping interventions occuring during rotation of the OSCE stations just before the start of the next upcoming OSCE station, in medical student, during the OSCE.

Eligibility Criteria:
Inclusion Criteria:

* all volontary medical students of the second cycle that came for their exam during the sessions of June 2024 from the University of Lyon (Medecine ESt)

Exclusion Criteria:

* no exclusion criteria
Narcotic-Free Percutaneous Nephrolithotomy

This is a randomized control trial comparing oral ketorolac and opioid medication for the use of post-operative analgesia.

This is a randomized control trial comparing oral ketorolac (10mg, Q6 PRN) and oxycodone (5mg, Q6 PRN) medication for the use of post-operative analgesia after kidney stone removal surgery called percutaneous nephrolithotomy (PCNL). Primary endpoints are visual analog pain scores (VAS) for days 1-5 and day 10 post operatively. Secondary endpoints are pill counts, patient-related outcome survey (PROMIS) scores, emergency room visits, and patient telephone calls. 90 subjects will be enrolled, with 45 in each group.

Eligibility Criteria:
Inclusion Criteria:

* Undergoing scheduled unilateral standard (24Fr), PCNL with at least 2cm stone burden, with expected single access

Exclusion Criteria:

* Pregnant women
* History of chronic opioid abuse
* Allergy, hypersensitivity, or other contraindication to NSAID usage such as

  * eGFR \< 60 mL/min
  * Peptic ulcer disease or history of gastric bypass
  * Concurrent use of antiplatelet or anticoagulation therapy (including aspirin)
  * Thrombocytopenia
  * Suspected or confirmed cerebrovascular bleeding, patients with hemorrhagic diathesis, incomplete hemostasis, and those at high risk of bleeding.
  * Concomitant medications:

    * Other NSAIDs
    * Antiplatelet or anticoagulation medications
    * Probenecid
    * Pentoxifylline
* Allergy, hypersensitivity, or other contraindication to opioids:

  * Current opioid prescription/usage for any reason, including active treatment with suboxone or methadone
  * Respiratory depression
  * Patients with acute or severe bronchial asthma or hypercarbia
  * Patients who have or is suspected of having paralytic ileus as PCNL done under general anesthesia
  * Patients with hepatic Impairment
  * Concomitant medications:

    * Monoamine Oxidase Inhibitors (MAOIs)
    * Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics
* Diagnosis of chronic pain disorder
* Reduced sensation of abdomen or pelvis (e.g. patients with spinal cord injury)
* Pre-existing stent or nephrostomy tube
* Urinary tract anomalies such as urinary diversion, horseshoe kidney, solitary kidney, urinary stricture disease, ureteropelvic junction obstruction, pelvic kidney, stone in calyceal diverticulum)
* Pulmonary disease
* Liver disease
* Seizure disorders
* Subjects taking nephrotoxic medications
* Subjects taking medications that can increase sedation risk (benzodiazepines or other sedative hypnotics)
Vaccine Acceptance in Pregnant Minority Women

The purpose of study will be to test two vaccine education strategies to learn how they impact flu and pertussis (Tdap) vaccination rates and attitudes regarding vaccination during pregnancy after participating in the intervention. The education strategies will be based on the elaboration likelihood model (ELM). This model is based on experimental psychology and has been previously used to increase breast cancer screening rates. These education strategies will be delivered through routine prenatal care visits to black/African-American women in Atlanta.


Eligibility Criteria:
Inclusion Criteria:

* Pregnant, expecting delivery between August 31, 2012 and June 30, 2013
* Between the ages of 18-50 years old
* Black/African American

Exclusion Criteria:

* Have received the influenza or Tdap vaccine during the current pregnancy
* Already enrolled in the study
Tai Chi for Improving Functions of Frail Older Adults

The goals of this study are to examine the physical function, cognitive function, and quality of life among frail elderly residing in the community

This randomized clinical trial recruited 100 frail older adults, assigned to either the Tai Chi group or the wait-list control group. Tai Chi intervention will be provided to the Tai Chi group for 12 weeks with 12-week follow-up and pretest and posttest measures will be conducted.

The primary outcome is the function variables (physical function of balance, flexibility, mobility; cognitive function of MOCA-K) The secondary outcome is quality of life measured by SF12.

Eligibility Criteria:
Inclusion Criteria:

* being frail (3 out of the following 5 criteria): feeling fatigued, difficulty climbing 10 stairs without help, difficulty walking 300m without help, more than 5 chronic illness, weight loss 5 % or more past 1-5 years
* living in the community
* able to participate in Tai Chi program twice a week

Exclusion Criteria:

* participated in any formal exercise program past 6 months
* not have transportation to come to the class
Fecal Microbiota in Preterm Birth

We will compeer fecal microbiome in preterm birth with fecal microbiome of team labor


Eligibility Criteria:
Inclusion Criteria:

* Woman after vaginal delivery of singleton

Exclusion Criteria:

* Fetal abnormalities
* Gestational diabetes
* Hypertensive disorder
Four-week Omeprazole Treatment of Non-erosive Reflux Disease in a Japanese Population

The purpose of this study is to study safety and efficacy of omeprazole standard treatment in a Japanese non-erosive reflux disease population.


Eligibility Criteria:
Inclusion Criteria:

* Patients who identified their predominant symptom as heartburn and were classifiend as Grande M or N according to Hoshihara's modofied version of Los Angeles Classification at esophagogastroduodenoscopy.

Exclusion Criteria:

* Patients with any ongoing gastrointestinal bleeding at the time of esopgahogastroduodenoscopy, patients with any history of erosive esophagitis or any other major diseases or concommittant drugs likely to interfere with the evaluation of this study
A Study to Evaluate the Efficacy and Safety of AD-209

The purpose of this study is to evaluate the efficacy and safety of AD-209

Condition or disease : hypertension Intervention/treatment Drug : AD-209 Drug : AD-209-1A Drug : AD-209-1B Drug : AD-209-1C Drug : AD-209 Placebo Drug : AD-209-1 Placebo Phase : Phase 2

Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent
* Other inclusions applied

Exclusion Criteria:

* orthostatic hypotension with symptom
* Other exclusions applied
Correlation Between Oocyte and Embryo Mechanical Properties on Embryo Development and Clinical Pregnancy After In Vitro Fertilization

The purpose of this study is to determine whether oocyte and embryo mechanical properties measured during in vitro fertilization can predict embryo development outcomes and clinical pregnancy.

In the current practice of in vitro fertilization (IVF), clinicians often transfer multiple embryos to the patient at once in an effort to maximize chances of pregnancy. This practice results in a high rate of multiple births which increase the risks of complications for mothers and children.

The investigators in this study have developed a novel, noninvasive marker of embryo viability which is based on measuring embryo mechanical properties at the oocyte or the 1-cell stage. The investigators would like to test whether human oocyte or embryo mechanical properties are predictive of subsequent development, clinical pregnancy, and compare their predictive power to that of a morphological assessment (the current gold standard). Using this approach, clinicians could more confidently move toward single embryo transfer, provided more individualized counseling for patients undergoing oocyte cryopreservation, as well as improve pregnancy rates after IVF.

This is a pilot observational study. Although investigators will measure the mechanical properties of all participant oocytes and embryos, no prediction of embryo viability will be made, and there will be no intervention in choosing which embryos to transfer to participants. The data from this study will eventually be used to find a range of oocyte and embryo mechanical parameters which are predictive of high developmental potential, and will serve as the basis for an interventional study in the future.

Eligibility Criteria:
Inclusion Criteria:

* Between the ages of 21 and 45
* Undergoing intra-cytoplasmic sperm injection (ICSI) at Stanford Fertility, Shenzhen IVF clinic, or Taiwan IVF group between August 2015 and August 2018

Exclusion Criteria:

* Using gestational carrier or donor eggs
* Using cryopreserved eggs
* Fewer than 5 oocytes collected
Can Exercise Training Reduce the Frequency and Severity of Hot Flushes Associated With Breast Cancer Treatment?

In brief, this study sets out to understand if exercise training can reduce the frequency and severity of hot flushes associated with breast cancer treatment.

In detail, the aim of this research project is to investigate whether improving temperature control mechanisms including vascular function, with exercise training is beneficial in alleviating hot flushes in breast cancer patients and their associated quality of life symptoms. Participants will be recruited at least 3-months post breast cancer treatment (surgery, radio-therapy, chemotherapy). This time point has been chosen for this study to allow patients to fully engage in the exercise intervention following treatment. All participants will be asked to attend the laboratory at Liverpool John Moores University on 4 separate occasions; 2 visits pre- and 2 visits following the exercise intervention for data collection including measures of vascular health, physical activity, sedentary behaviour, and fitness. The investigators will also gain information on food intake and incidence of hot flushes across a 7-day period pre- and post the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Able to provide written informed consent
* Pre-menopausal, Peri-menopausal or post-menopausal
* \>4 hot flushes per day
* Female
* Treated with tamoxifen or aromatase inhibitor

Exclusion Criteria:

* Uncontrolled or severe hypertension (blood pressure \> 160/100 mm Hg)
* Any previous injury preventing exercise
* Type 1 or 2 diabetes
* Anti-depressants
* Currently undergoing chemotherapy or radiotherapy
* Current smoker
* Cannot readily read and understand English
MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma

This trial studies how well MoleMapper, Visiomed, and confocal microscopy work in screening participants for melanoma. Analyzing images (photographs) made with three different portable imaging systems may be as good as a visit to a dermatologist's office for finding melanomas before they can spread.

PRIMARY OBJECTIVE:

I. To assess the clinical utility of clinical images, digital dermoscopy images and in-vivo confocal microscopy for teledermatology.

SECONDARY OBJECTIVE:

I. To incorporate in vivo confocal images into the triage system in order to determine to what degree the information gathered in this modality changes the classification of a lesion assigned by a licensed dermatologist.

TERTIARY OBJECTIVE:

I. To assess the potential improvement of virtual patient triage when adding digital dermoscopy images to clinical images presented by patients to their provider (via e-visit or e-consult).

OUTLINE:

Participants undergo imaging of suspicious moles via smartphone application (app) MoleMapper/Sklip app/native smartphone camera app, digital dermoscopy, and confocal microscopy. Participants then receive lidocaine subcutaneously (SC) and undergo shave or punch biopsy of suspected melanomas.

After completion of study intervention, patients are followed up within 1 week.

Eligibility Criteria:
Inclusion Criteria:

* Persons who participate in the free skin cancer screening at the PDX Skincare Festival at Oregon Health \& Science University (OHSU) in 2021/2022 (date pending) and are informed by a provider that they have a pigmented lesion for which a biopsy is recommended are potentially eligible to participate in this study.
* Persons who participate in the free skin cancer screening at the War on Skin Cancer event at OHSU in 2021/2022 (date pending) or other dates and locations and are informed by a provider that they have a clinically benign or atypical nevi are eligible to participate in the imaging portion of this study. No biopsy will be offered to these participants.
* Persons age 18-80 are eligible for the study
* Persons of any sex can be enrolled.
* Persons of any race are eligible but we anticipate that most participants will be Non-Hispanic whites due to the prevalence of melanoma and other skin cancers in this group.
* Only persons who can provide signed statement of informed consent will be enrolled.
* Persons who are identified in OHSU Dermatology clinics or through OHSU e-visit and e-consult platforms as having a skin lesion in need of a biopsy for skin cancer
* Persons identified via the Melanoma Community Registry (MCR) (IRB approved: 00010561)

Exclusion Criteria:

* Allergy to the anesthetic (lidocaine).
Study Of Dalbavancin Drug Levels Achieved In Hospitalized Adolescents Who Are Receiving Antibiotic Therapy For Bacterial Infections

Adolescent subjects hospitalized for the treatment of bacterial infections will be given 1 gram of dalbavancin through their veins and levels of dalbavancin in blood and urine will be measured at different time points. Safety labs will also be checked on a regular basis to assess the safety of dalbavancin.


Eligibility Criteria:
Inclusion Criteria:

* 12 to 17 year old adolescents hospitalized for the treatment of bacterial infections.

Exclusion Criteria:

* Patients being treated with vancomycin.
* Patients with liver and kidney failure.
* Pregnant female subjects.
Austrian Myeloid Registry

The Austrian Myeloid Registry (aMYELOIDr) is a non-interventional study. It collects data from patients with the myeloid diseases, primarily myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).The aMYELOIDr is multi-center database collecting data at various sites in Austria and potentially also at other centers in other countries in future. The registry has an electronic case report form (eCRF), where all data is entered by clinical trial personnel and/or physicians. It is set up to collect real-world experience in the management of patients with these diseases in Austria.


Eligibility Criteria:
Inclusion Criteria:

* Age \>17 years
* Diagnosis of myeloid disease according to WHO 2016
* Signed patient informed consent (IC)

Exclusion Criteria:

* Patient is unable or unwilling to sign IC
Online Patient Navigation Program for Patients with Breast Cancer

The goal of this prospective 1:1 randomized controlled trial is to evaluate if an online patient navigation program, designed to identify targeted supportive care needs and to facilitate referrals and web-based interventions to address these needs, can increase patients' access to supportive care services, compared to traditional in-person patient navigation providing referrals to in-person supportive care services

The main questions it aims to answer are:

* Does online patient navigation increase access to supportive care services by ≥30% among patients with breast cancer?
* Which are the barriers that hinder patients\&#39; access to the supportive care services they require?
* What is patients\&#39; level of satisfaction with online patient navigation?

Researchers will compare the online patient navigation program to traditional in-person patient navigation providing referrals to in-person supportive care services to assess if online patient navigation increases patients' access to supportive care services.

Participants will:

* Participate in an online or in-person patient navigation program for 4 weeks
* Answer the study surveys at baseline and 4 weeks of follow-up


Eligibility Criteria:
Inclusion Criteria:

* Female sex
* Age ≥18 years
* Diagnosis of non-metastatic breast cancer
* Internet access at home or in their mobile phone
* Availability to answer the study surveys
* Provision of signed informed consent

Exclusion Criteria:

* Disease recurrence
* Inability to read or write
Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients

Study to test the hypothesis that aerosolized Infasurf can decrease the need for intubation and instillation of liquid surfactant to the airway.

Treatment will not be masked. The study objective is to document that aerosolized Infasurf is superior to "usual care" and provides for some patients effective surfactant therapy with less need for endotracheal intubation and instillation of a surfactant suspension into the airway. Two cohorts will be recruited: (a) patients who did not receive surfactant at birth who develop RDS in the first hours of life and (b) patients who received instillation of surfactant for RDS in the first hour of life, were extubated, and have continuing RDS.

Eligibility Criteria:
Inclusion Criteria:

RDS Patients

1. NICU patient, ≥1hour of age and \<24 hours of age.
2. Clinical diagnosis of RDS, with or without chest X-ray data.
3. Inspired oxygen ≥21% to maintain adequate oxygen saturation.
4. Not intubated
5. Requiring:

   1. nasal continuous positive airway pressure (nCPAP).

Exclusion Criteria:

1. Congenital anomaly limiting care options or requiring early surgery.
2. Cardiopulmonary decompensation.

   1. hypotension with metabolic acidosis (base excess \< -10 meq/l).
   2. Oxygen saturations \< 88% at start of aerosolization.
   3. PaCO2 ≥ 60 mmHg at start of aerosolization.
3. Grade 3 or Grade 4 intraventricular hemorrhage by cranial ultrasound, if known.
4. Acute hypoxic encephalopathy with or without seizures.