cyrilzakka/clinical-trials huggingface dataset:
Virtual Overdose Response

To help prevent deaths in populations that cannot or will not access physical safer consumption services in Alberta, which may disproportionately include women and those who are not able to self-inject (Potier et al., 2014) the investigators propose to provide virtual (phone-based) supervised consumption services, staffed by people with lived experience.

Designed as a small open label clinical study to demonstrate proof of concept which will follow CONSORT guidelines, the investigators aim to recruit approximately 15 people who are currently using illicit substances and who currently use opioids (illicit or prescription - non-medically). The sample size of 15 balances pragmatic issues (difficulty in recruiting people who are actively using illicit substances) and the need to have a good sample of the population. These participants will be interviewed by the research coordinator in person prior to intervention initiation to determine baseline use; history of overdose; and current harm reduction activities (see appendix). They will then be asked to call the intervention number if they are going to be using alone (see appendix for call flow).

Each time a participant dials the number, the operator will gather (as part of the intervention) the address the participant is at, their name/pseudonym and a phone number that can be used as a call back number in case the call is disconnected. The phone line operator will then ask a) what they planned on using, b) the method of use, c) if the participant is using safe sterile supplies (and provide information on where they can get new supplies in their community), and d) if they have a naloxone kit (overdose reversal kit) available. They will then inform the participant that they will be checking in on them every 5 - 10 minutes and if they do not respond, they will call emergency medical services for them.

If the participant responds to each verbal prompt (calling their name) over a minimum of 30 minutes, the operator will let them know that they are disconnecting the call. The operator will offer to connect the participant to other health services, such as the location of new supplies, social services, addiction treatment and opioid agonist therapy. If the participant fails to respond to a prompt (or the call is disconnected and is not able to be reconnected), the operator will contact the dispatch supervisor and the process for emergency services dispatch will be initiated.

Eligibility Criteria:
Inclusion Criteria:

* Able to give informed consent - able to speak and understand English and over 18 years of age
* Admit to using opioids non-medically: using illicit opioids; using prescription opioids without a current prescription; using doses greater than those prescribed; using opioids recreationally
* Have access to a phone line in the location they primarily use opioids: this can be a land line or a cell phone
* Resident of Calgary

Exclusion Criteria:

* Unable to give informed consent - unable to understand English, under 18 years of age or otherwise not legally able
* Do not knowingly use opioids non-medically
* No access to a phone
* Live outside of Calgary
Female Teacher's Voice During Teaching

Two voice therapy methods are compared. Activity noise levels and vocal load of teachers during teaching in primary school classrooms are evaluated. Acoustic and Workshop Interventions are implemented in order to reduce noise level during lesson.

Due to the voice disorders, teachers are a major customer group for voice therapy. The main part of the study is comparison of two voice therapy methods.

There are several factors in the classroom that increase teacher's risk of voice disorders. One of the most significant is high noise level during lessons. This study explores the noise conditions the teachers are working in and how these conditions are related to the voice parameters and symptoms.

Finally, the study aims to determine whether classroom noise level can be lowered by improving classroom acoustics and by noise reducing workshops for teachers and pupils.

Eligibility Criteria:
Inclusion Criteria:

* Female teachers or teachers of special needs children from elementary schools
* Voice symptoms and willingness to participate in voice therapy
* Mother tongue Finnish
* No hearing loss, no need to use a hearing aid
* Non-smoking
* No neurological diseases
* No voice therapy during past year
* Successful phoniatric examination with rigid laryngoscopy or nasal endoscopy

Exclusion Criteria:

* Mother tongue other than Finnish
* Need to use a hearing aid
* Need for medical treatment in the larynx
* Abnormalities of the larynx
* Vocal cord paresis
* Laryngitis
* Posterior hypertrophy
Hip and Knee Moments Normal and With Scoliosis

Kinetic analysis appears to be useful in providing objective information regarding the gait abilities of scoliotic patients which is difficult to be observed in a clinical setting. Objective: the aim of the study was to analyze the hip and knee peak abductor moments during gait in subjects with idiopathic scoliosis.

The hip and knee abductors' moments normalized to body weight have been investigated in normal subjects and subjects with idiopathic scoliosis. The scoliosis group included a twenty-two-moderate idiopathic dorso-lumbar single scoliotic curve. The control group contained a normal twenty-two subjects. 3D motion analysis system and force plat were used for data collection for hip and knee abductor moment. MANOVA was used to study the difference between normal and scoliotic groups' hip and knee abductor moments in both lower limbs. at alpha level of significance of 0.05.

Eligibility Criteria:
Inclusion Criteria:

* normal subjects free from any musculoskeletal problems
* subjects with moderate idiopathic scoliosis (cobb angle 25-35)

Exclusion Criteria:

* any musculoskeletal affection rather than scoliosis, neurological manifestations, or previous major surgeries
Analgesic Efficacy of Perineural Dexamethasone During Supraclavicular Block for Hand Surgery

The purpose of this study is to determine whether the addition of dexamethasone prolongs analgesia when added to long-acting local anesthetic during single-injection supraclavicular block for outpatient hand surgery.

The goal for pain control after surgery is to provide the best possible pain control for the longest period of time with the least amount of side effects. One type of pain medication is called local anesthetic, which is a numbing medication that is injected in the area surrounding nerves to block pain. This injection is called a nerve block. Ropivacaine is a local anesthetic that is commonly used for nerve blocks and will be used in this study. The effects of ropivacaine may last for 8 to 12 hours after surgery. Recent research studies have shown that adding a medication called dexamethasone (a steroid) may increase the time that the nerve block will provide pain control. The purpose of this study is to see if adding dexamethasone to ropivacaine and injecting this around the nerves during a supraclavicular brachial plexus block increases the duration of pain relief as compared to both placebo control and systemic control groups.

Eligibility Criteria:
Inclusion Criteria:

* Patients 18 years of age and older
* Patients scheduled for elective outpatient hand surgery with same day discharge at the Duke Ambulatory Surgery Center

Exclusion Criteria:

* Patients who refuse regional anesthesia
* Patients in whom peripheral nerve block is contraindicated
* Patients unable to sign/understand consent
* Patients with significant language barriers who cannot comply with data collection process
* Patients with known allergies to local anesthetics
* Pregnancy
* Chronic pain patients or patients requiring chronic opioid treatment
* Patients with a history of diabetes
* Patients with contraindication to steroid administration (allergy, chronic steroid use)
mNGS Was Applied to the Study of Pathogen Identification, Precision Medication and Efficacy Evaluation of Infected Patients

1) prospectively collected the patients with the proposed infection, confirmed the infection or excluded the infection through mNGS detection combined with traditional pathogen detection methods and clinical characteristics, compared the detection performance of mNGS and traditional methods, and explored the significance of mNGS microbial map characteristics for the diagnosis/exclusion of infection; 2) real-time dynamic monitoring of the pathogen and microecology of infected patients during the targeted drug use, and evaluation of the efficacy in combination with other indicators; 3) to explore the significance of the number of pathogen sequences before the clinical withdrawal of drugs to the clinical practice.


Eligibility Criteria:
Inclusion Criteria:

* 18 to 75 years old
* expected length of stay in ICU was \> 24 h
* suspected infected patients (PSI or CPIS, qSOFA or SIRS)

Exclusion Criteria:

* Pregnant and lactating women
* Who has not signed the informed consent
* the researchers considered that others were not suitable for the study
Probiotics on Body Composition and Insulin Resistance in Patients With Obesity and Its Association With Gut Microbiota

This study aims to evaluate the modifications in body composition and insulin resistance state in patients with grade II and III obesity included in an interventional lifestyle changes program and treated with probiotics (1 x 1011 CFU) or placebo for 16 weeks and its associations with intestinal microbiota behaviour

A randomized placebo-controlled clinical trial will take place in which both arms will be included in an interventional lifestyle changes program at the Clinic for Integral Treatment of patients with Diabetes and Obesity. The study group will be treated with probiotics (1 x 1011 CFU) for 16 weeks and will be compared to a control group who will receive placebo.

Changes in body composition (weight, BMI, fat percentage, fat mass, lean body mass) and insulin resistance indexes (HOMA, insulin sensitivity index and Quicki) will be evaluated in patients with obesity receiving probiotics (1 x 1011 CFU) for 16 weeks, and compared to a placebo group.

Changes in metabolic profile (glucose tolerance test, glycosylated haemoglobin, lipid profile, leptin and transaminases) in patients with obesity receiving probiotics (1 x 1011 CFU) for 16 weeks, and compared to a placebo group.

Changes in microRNAs profile (miR-133 and miR-27 in patients with obesity receiving probiotics (1 x 1011 CFU) for 16 weeks, and compared to a placebo group.

The threshold for basic tastes will be evaluated (salted, bitter, acid, sweet) and will be evaluated in those patients receiving probiotics (1 x 1011 CFU) for 16 weeks, and compared to the group receiving only placebo.

Changes in intestinal microbiota behaviour will be evaluated in participants with obesity receiving probiotics (1 x 1011 CFU) for 16 weeks, and compared to the group receiving placebo.

Eligibility Criteria:
Inclusion Criteria:

* Patients with grade II y III obesity (IMC \> or = 35 Kg/m2), who receive the initial evaluation at the Integral Attention Clinic for Diabetes and Obesity at Hospital General de México
* Patients who signed informed consent.

Exclusion Criteria:

* Diabetes mellitus 2
* Secondary causes of obesity (hypothyroidism, Cushing syndrome).
* Patients receiving pharmacological treatment that may affect lipid or glucose metabolism.
* Patients who received broad-spectrum antibiotics during the 4 previous weeks.
* Ingestion of products that contain probiotics.
* Relevant changes in diet habits during the 4 previous weeks
* Intestinal Malabsorption disorders ( inflammatory bowel disease, chronic diarrhea, C. difficile infection).
Clinical Characteristics in Congenital Cataract Eyes

This study involved children with congenial cataract eyes, who underwent cataract surgeries at the Eye Hospital of Wenzhou Medical University (Hangzhou, China). All medical records were reviewed for primary diagnosis. All surgeries were performed by one experienced surgeon (Z.Y.E) and videos were collected for reviews in details. the clinical data after the surgery were also recorded for further analysis.


Eligibility Criteria:
Inclusion Criteria:

* children with congenital cataracts who underwent cataract surgeries at the Eye Hospital of Wenzhou Medical University (Hangzhou, China)

Exclusion Criteria:

* ocular trauma
mHealth ALIBIRD: A Digital Health Care Model

The aim of this pilot study was to evaluate the feasibility and acceptability of the ALIBIRD platform, a new mobile health (mHealth) application prototype design for personalized and remote support on the follow-up of cancer patients. The ALIBIRD platform is a mHealth intervention that tracks PROs, improving symptom control and allowing real-time feedback, and provides personalized recommendations and educational content, promoting empowerment and encourage healthy lifestyle behaviors in patients with thoracic neoplasms in active treatment.

The investigators have developed an innovative mHealth platform that provides personalized recommendations based on Patient Reported Outcomes (PROs) records and the study of patient´s nutrigenomics and gut microbiome. The usability of the ALIBIRD mHealth platform prototype is being tested in a 28-week pilot study carried out at Infanta Sofía Hospital. A small group of stage IV thoracic neoplasms patients (n=20) were asked to participate. All the participants gave informed consent.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with thoracic neoplasms, histologically or cytologically confirmed.
* \< 18 years.
* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
* Patients receiving cancer treatment: chemotherapy, chemotherapy-immunotherapy, immunotherapy or biological therapy.
* Patients with internet access and intermediate level in the use of technology (Smartphone, mobile applications, wearable)
* Signed informed consent.

Exclusion Criteria:

* Patients with symptomatic brain metastases.
* Patients with neurological impairment, dementia or psychiatric disorders.
* Patients unable to follow the protocol due to psychological, social or geographic reasons.
A Study of Language Interpretation Solutions for People With Breast Cancer

The study will be conducted in 2 overlapping phases. In Phase 1, there will be a 3-arm randomized controlled trial of Remote Simultaneous Medical Interpreting/RSMI (Arm 1), versus Remote Consecutive Medical Interpreting/RCMI (Arm 2) and versus Remote Consecutive Video Medical Interpreting/RCVI (Arm 3) in breast cancer outpatient clinical encounters with Spanish- and Mandarin-speaking patients with Limited English Proficiency/LEP (Stages II and III disease) and English- speaking providers (who do not speak Spanish/Mandarin). In Phase 2, there will be a sequential mixed-methods explanatory, multi-stakeholder process evaluation to gather implementation potential data.


Eligibility Criteria:
Inclusion Criteria:

Phase I Patients

* Age \>=18 years (per EMR)
* Preferred language for healthcare is Spanish or Mandarin (per self-report)
* Limited English Proficient; cannot speak English "very well" (per self-report)
* Diagnosis of Stage I, II, III, or IV breast cancer within the past two months (per EMR)
* Will be visiting MSK oncologist for the first or second appointment (per EMR)
* Will be continuing medical oncology visits at MSK (per EMR)
* Agrees to be audio-recorded (per self-report)

Phase 1 Providers

* Breast cancer provider who sees patients (e.g., breast oncologists, advanced practice providers, and/or nurses)
* Does not speak Spanish and/or Mandarin; providers who speak one language and not the other may participate (e.g., speaks Spanish but not Mandarin) (per self-report)
* Agrees to be audio-record (per self-report) Phase 2 (clinic staff only; patient participants will be drawn from Phase 1)
* Is a staff member who works/worked in one of the study clinic sites during the period of Phase 1 RCT study activities
* Agrees to be audio-recorded (per self-report)

Exclusion Criteria:

Phase 1 Patients

* Has significant psychiatric disturbance (i.e., acute psychiatric symptoms) sufficient to preclude completion of the assessments, interviews, or informed consent (per EMR, patient's care team, or study team)
* Presence of cognitive impairment disorder (i.e., delirium or dementia) sufficient to preclude meaningful informed consent and/or data collection (per EMR, patients, care team, or study team)

Phase I Providers

* None

Phase 2 (clinic staff only; Phase 1 patient participants follow above criteria)

* None
Comparison of the Acute Effects of Different Warm-up Protocols in Overhead Athletes With Posterior Shoulder Tightness

The aim of this study is to investigate the immediate effects of different warm-up protocols on Shoulder mobility, Muscle stiffness, Muscle power performance, Shoulder functional ability and Shoulder endurance in overhead athletes with posterior shoulder tightness


Eligibility Criteria:
Inclusion Criteria:

* Recreational or amateur athletes between the ages of 18 and 40
* Training time exceeding four hours per week
* Shoulder internal rotation is reduced by more than 15 degrees compared to the non-dominant side, or the sum of shoulder external rotation and internal rotation is less than 15 degrees compared to the non-dominant side or Shoulder horizontal adduction is reduced by move than 15 degrees compared to the non-dominant side

Exclusion Criteria:

* Shoulder pain within the past three months
* History of shoulder fracture, dislocation, or soft tissue tear surgery in the past
* Contraindications for massage include: open wounds in the treatment area, skin cancer, infections in the treatment area, and severe edema
Psychometric Properties of the Chinese Version of PeNAT

Cancer is a leading cause of death for children. Chemotherapy is the most common treatment for cancer. Notwithstanding the improved survival, children with cancer still have to face a significant amount of symptoms associated with chemotherapy. Two major symptoms induced by chemotherapy are nausea and vomiting. These two symptoms were demonstrated to cause serious disruption in patients' daily function and quality of life. Given these devastating impacts, intervening children with appropriate methods to alleviate nausea and vomiting during chemotherapy is therefore crucial. It is imperative for nurses to develop non-pharmacological interventions to reduce nausea and vomiting, with the goal of improving the QoL of children with cancer when undergoing chemotherapy First, however, careful assessment of nausea and vomiting in children with cancer is a necessary step towards designing appropriate interventions. This study aims to translate and validate an instrument (PeNAT) which can assess nausea and vomiting among Hong Kong Chinese children and adolescents undergoing chemotherapy

Currently, the most effective anti-emetics appear to be 5-HT3 inhibitors, followed by NK1 inhibitors and neuroleptic drugs. Nevertheless, anti-emetics alone are not sufficient to manage these two symptoms. This poor symptom control could be due to healthcare professionals' perception that nausea and vomiting are solely biological problems, and their heavy reliance on pharmacological treatment for management. After literature search, we can identify only one validated instrument, the Pediatric Nausea Assessment tool (PeNAT), assessing chemotherapy-induced nausea and vomiting in children. Yet, this instruments is not available in Chinese. This study aims to translate and validate an instrument (PeNAT) which can assess nausea and vomiting among Hong Kong Chinese children and adolescents undergoing chemotherapy

Eligibility Criteria:
Inclusion Criteria:

* Aged 4 - 17
* A confirmed diagnosis of cancer
* Currently undergoing chemotherapy
* Able to speak Cantonese and read Chinese

Exclusion Criteria:

* Cognitive or behavioral problems in medical records
Effects of Aerobic Thai Dance in Patient With Diabetic Peripheral Neuropathy

The goal of this type of study is clinical trial. This to learn about effects of applied aerobic Thai dance exercise on gait balance and sudomotor function in patient with diabetic peripheral neuropathy. Test variables of gait, balance, function of sudomotor, Physiological data such as pulse, blood pressure, body composition, ankle and leg muscle strength, compare with control and experimental group in diabetes with peripheral neuropathy.

The main question Question 1: Dose Applied aerobic Thai dance exercise affects gait and balance in diabetic patients with peripheral neuropathy? Question 2: Does applied aerobic Thai dance exercise affect sudomotor function in diabetic patients with peripheral neuropathy? Participants will divided into 2 groups: the control group and the experimental group. By randomly sampling 22 people from each group

1. The control group was advised to exercise at home for a period of 12 weeks.
2. The experimental group participated in Applied aerobic Thai dance exercise 60 minutes per session, 3 times per week, for a period of 12 weeks.

After 12 weeks, variable data were collected and to compare within and between groups.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with type 2 diabetes between the ages of 60 and 75.
* The BMI index is between 18.5 - 29.9 kg/m2.
* MNSI score between 2.5 - 7.5 points.
* There were no exercise-related complications from the PAR -Q assessment.
* Light to moderate level of physical activity.
* Not being a person with severe optic neuropathy (Severe-NPDR and Severe-PDR).
* No wounds or infections on the feet.
* No musculoskeletal abnormalities.
* Not being a Pacemaker Implantation Person, No History of Heart Failure, Evaluated New York Heart Association Classification (NYHA) not over Functional Class II, If CAD must be treated, No history of Atrial Fibrillation severely wrong.
* The doctor did not have a plan to adjust the medication in the last 3 months.

Exclusion Criteria:

* MNSI score greater than or equal to 8 points or more.
* Participants lacked more than 20 percent of their exercise program.
* Participants had foot ulcers and infections during the experiment.
* Vitamins B1, 6 and 12 were taken during the trial.
* The subject withdrew from the experiment.