cyrilzakka/clinical-trials huggingface dataset:
The ENERGYCO Study

The aims of this school-based cycling intervention called "ENERGY Commuting to school" (ENERGYCO) will be divided into two phases: Phase I will aim: 1) to design, test, and validate predictive equations for the objective quantification of the energy expenditure related to different modes of commuting to school (i.e., walking, cycling, motorized-vehicle); and 2) to quantify the energy expenditure of each mode of commuting to school using indirect calorimetry in adolescents; and Phase II will aim to evaluate the effect of a school-based cycling intervention on different health-related outcomes, such as energy expenditure, resting metabolic rate, basal metabolism, physical activity levels, body composition, muscle strength, cardiorespiratory fitness, blood pressure, physical literacy, motor competence, and psychosocial outcomes on Spanish adolescents.

The ENERGYCO study is a cluster-randomized controlled trial focused on the energy expenditure associated with commuting to school. Phase I will aim to develop predictive equations for quantifying energy expenditure during different modes of commuting (walking, cycling, motorized-vehicle) and to measure energy expenditure using indirect calorimetry in adolescents. Phase II will assess the impact of a school-based cycling intervention on various health outcomes in Spanish adolescents, including energy expenditure, metabolic rate, physical activity levels, body composition, muscle strength, fitness, blood pressure, physical literacy, motor competence, and psychosocial outcomes. Phase I will involve recruiting approximately 50 adolescents to quantify energy expenditure during walking, cycling, and motorized-vehicle. For Phase II, a random sample of around 300 schoolchildren aged 12-16 from three Spanish cities will undergo a eight-week cycling intervention involving Bikeability sessions and encouragement strategies. Therefore, the ENERGYCO study aims to develop predictive equations for measuring energy expenditure during active commuting to school and assess the impact of a cycling intervention on adolescent health. It is expected to contribute significantly to research and society by providing insights into the effects of active commuting and cycling interventions on adolescent energy expenditure, physical and mental health.

Eligibility Criteria:
Inclusion Criteria:

1. the school has a specific space for parking bicycles and allows for their parking
2. the school does not have a specific school bus route
3. the school has at least two lines per class
4. at least eight students from the school will agree to participate in the study (i.e., presenting a signed parental consent).
Reduction in Clinical Variance Using Targeted Design Changes in Computerized Provider Order Entry Order (CPOE) Sets

Selective redesign of order sets using different ways to frame the order and physician decision-making in a computerized provider order entry system could increase adherence to evidence-based care and reduce population-specific variance.

Variance in ordering of care can be characterized as the lack of uniform use of specific treatments by clinicians for a given medical condition. Unwarranted variance in healthcare has been associated with prolonged length of stay, diminished health and increased cost. Practice variation in the management of asthma can be significant and few investigators have evaluated strategies to reduce this variation. We hypothesized that selective redesign of order sets using different ways to frame the order and physician decision-making in a computerized provider order entry system could increase adherence to evidence-based care and reduce population-specific variance.

Eligibility Criteria:
Inclusion Criteria:

* All patients admitted using an acute asthma exacerbation order set.

Exclusion Criteria:

* Patients who did not have either an admission or discharge diagnosis of asthma exacerbation.
* In addition, patients admitted to the intensive care unit directly or transferred to the intensive care unit within 24-hours were excluded from analysis.
* Finally, patients were excluded from analysis if asthma was not the presenting problem.
Applications of MRI in Kidney Disease

This study has two major purposes:

1. To test developed multiple anatomic and functional MRI methods;
2. To evaluate the potentials of these MRI methods in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction.

These purposes will be achieved by performing pilot studies with cohorts of patients.

This study is observational with no intervention applied for the patients. In this study, multiple anatomic and functional MRI methods will be performed with three cohorts of patients. In addition to anatomic MRI methods, non-contrast enhanced functional MRI methods will also be applied to evaluate tissue perfusion and vascular reactivity in these patients.

Eligibility Criteria:
Inclusion Criteria:

1. English-speaking as primary language
2. Able to complete an approximately 75 to 90 minute cognitive and/or physical tests
3. Capable to consent to studies

Exclusion Criteria:

1. Acute psychiatric illness that would impede cognitive testing
2. Active chemical dependence, such as alcohol, narcotics or other drugs
3. Legally blind or unable to complete cognitive tests due to visual loss or deafness
4. Renal transplant recipient at time of screening or baseline
5. Severe CI unable to complete the Modified Mini-Mental State Examination \[3MSE\]
6. Chronic and acute pulmonary disease
Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans

Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.


Eligibility Criteria:
Inclusion Criteria:

* Healthy men and women
* Aged 20-44 years
* Caucasian origin
* Body mass index (BMI) 19-25 kg/m2
* Used to drinking coffee (similar to study coffee) on a daily basis
* Being able to tolerate a 48-hour coffee abstinence
* Normal oral glucose tolerance test
* Having signed the informed consent form

Exclusion Criteria:

* Taking medication or dietary supplements
* Smoking
* Performing a competitive sport
* Having metabolic disorders
* Long gut transit time (\>24 h)
* Blood donor
* Irregularity in menstrual cycle (for women)
* Pregnancy (for women)
* Subject who cannot be expected to comply with the study procedures.
* Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.
Effect of Sling Suspension Exercises in Proprioception of Patients With Knee Osteoarthritis

Therapeutic exercise is important to patients with knee osteoarthritis. Few studies reported the effect of therapeutic exercise in proprioception for these patients. The purposes of this study were to investigate the training effect of sling suspension exercises, as a proprioception-training tool, for patients with knee osteoarthritis and further, to build up an model of proprioception training.

Therapeutic exercise is important to patients with knee osteoarthritis. Few studies reported the effect of therapeutic exercise in proprioception for these patients. The purposes of this study were to investigate the train-ing effect of sling suspension exercises, as a proprioception-training tool, for patients with knee osteoarthritis and further, to build up an model of proprioception training. Twelve subjects were recruited in this study. The inclusion criteria were aged 50 to 70, both genders, diagnosed as knee osteoarthritis, grading 2 or 3 in Kellgren's scale. After having their consents all subjects received baseline measurements including active joint reposition test, functional ambulating test and self-evaluating with Western Ontario \& McMaster Universities Arthritis Index (WOMAC). Then they were randomly assigned to training group and reference group. Seven subjects in the training group received the treatment of heat, interferential current (IFC), and sling suspension exercises or just only sling suspension exercises. Five subjects in the reference group received the treatment of heat and IFC or no intervention. The training sessions of sling suspension exercises were 3 times per week, lasting for8 weeks. After 8-week training, both groups were given post-test which is completely the same as pre-test. Mann-Whitney U Test was used to test the difference between groups, and Wilcoxon Signed Ranks Test was used to test pre-post difference in both groups. The results showed it was no difference between both groups in all the measurements of pre-test. After 8 weeks, it showed significant difference on joint reposi-tion test (p\<.05) but no difference on functional ambulating test and WOMAC index (p\>.05) between the 2 groups. In the training group, all mea-surements got significant improvement (p\<.05) except one of the functional ambulating tests. However, the reference group only showed significant improvement in pain and physical function subscales of WOMAC (p\<.05). This study concludes that the sling suspension exercises designed for patients with knee osteoarthritis improve the proprioception of knee joint. The con-tent and concept of sling suspension exercises in this study might be a refer-ence of proprioception training for patients with knee osteoarthritis. Increasing case number and elongating the duration of intervention are suggested in further studies.

Eligibility Criteria:
Inclusion Criteria:

* aged 50 to 70, both genders, diagnosed as knee osteoarthritis, grading 2 or 3 in Kellgren's scale

Exclusion Criteria:

-
Perceived Stress and Anxiety Levels of Nurses

This study was conducted to determine the effect of web-based progressive relaxation exercises applied to nurses working in a pandemic hospital on perceived stress and anxiety. In this randomized controlled clinical trial, nurses working in the pandemic hospital were randomly assigned to the control and intervention groups.

The coronavirus disease-2019 (COVID-19) epidemic increases the stress and anxiety level of nurses due to many factors. This study was conducted to determine the effect of web-based progressive relaxation exercises applied to nurses working in a pandemic hospital on perceived stress and anxiety. In this randomized controlled clinical trial, nurses working in the pandemic hospital were randomly assigned to the control and intervention groups. The Web-Based Relaxation Exercises Program was trained and implemented online for 4 weeks by a trainer for the intervention group.The Perceived Stress Scale (PSS) and the State-Trait Anxiety Inventory (STAI) were completed online by participants in both groups before and after the intervention

Eligibility Criteria:
Inclusion Criteria:

* Those between the ages of 18-55
* Nurses working in the pandemic hospital

Exclusion Criteria:

* Nurses who did not agree to participate in the study
* Research Termination Criteria;
* Nurses who begin to receive support from a psychiatrist,
* Nurses who begin to use psychiatric medication,
* Nurses who are COVID positive,
* Moreover, the study was terminated with the nurses who wanted to leave the study.
Normal Versus Dual Wave Insulin Bolus for High-protein Food

Patients receive a standardized high-protein test meal at breakfast time. Insulin is given as bolus (normal or dual-wave (normal plus square) and basal rate using an insulin pump. The 3h post-meal glucose excursions will be recorded by self-blood glucose measurements (SMBG) (every 1 hour) and continuous glucose monitoring system (CGMS). The intervention is taking part under in-patient clinical conditions.

The dual-wave bolus delivers an immediate normal pre-meal insulin bolus followed by square-wave bolus that is evenly delivered over several hours as programmed by the patient. The aim of this study is to compare post-prandial glycaemic excursions following a high-protein meal after administration of insulin by normal vs dual-wave bolus. During this prospective, cross-over, repeated measures study, pediatric patients with type 1 diabetes, treated with insulin pump therapy will be evaluated using the self-blood glucose measurements following standardized high-protein meal and two types of boluses (normal or dual-wave). The required insulin dose will be calculated based on patient's insulin-exchange ratio. A high-protein meal will be given on two subsequent breakfasts and comparisons will be made between normal and dual-wave insulin bolus delivery. Prolonged post-prandial glycaemic excursions will be identified using the CGMS.

Eligibility Criteria:
Inclusion Criteria:

* duration of type 1 diabetes longer than 12 months
* insulin pump therapy longer than 3 months
* written informed consent by patients and parents
* patients must be willing to wear a glucose sensor for two days
* insulin requirement more than 0,5 units/kg/day

Exclusion Criteria:

* concomitant dietary restrictions (e.g. celiac disease or food allergy)
* diabetes related complications (e.g. nephropathy)
* any disease judged by the investigator to affect the trial
* withdrawal of consent to participate in the study
PET-CT Predicting Segement Specific Lymph Nodes Metastasis

This study is a multicenter prospective clinical study that aims to evaluate the predictive value of preoperative PET-CT results (such as SUV uptake, size of tumor lymph nodes, and differences in FDG uptake compared to surrounding tissues) for lymph node metastasis in patients with non-small cell lung cancer. During surgery, all patients underwent systematic mediastinal lymph node dissection. The final pathological results were used to assess the predictive value of PET-CT for segment-specific lymph node metastasis.


Eligibility Criteria:
Inclusion Criteria:

* Solitary tumor, or multiple tumors with only ground-glass nodules (GGNs) apart from the primary lesion.
* Diameter of the primary lesion ≤5cm, with a CTR between 0.5 and 1.
* No enlarged mediastinal lymph nodes observed on preoperative contrast-enhanced CT.
* Pathological confirmation of non-small cell lung cancer (NSCLC) either before or during surgery.
* Systematic lymph node dissection performed during surgery.
* No prior radiotherapy or chemotherapy for initial treatment.
* No history of malignant tumors.

Exclusion Criteria:

* Locally advanced or distant metastasis.
* Pleural dissemination observed during surgery.
* History of malignant tumors.
* Received neoadjuvant therapy.
* Systematic lymph node dissection not performed during surgery.
* Histopathological examination reveals lung malignancies other than non-small cell lung cancer (NSCLC).
Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels

The investigators will study adaptation of motion perception and manual control in altered gravity, including the effects of a drug (promethazine). The investigators will also study whether promethazine affects motion perceptual thresholds.

Adaptation to altered gravity has been of concern from the earliest reports of space motion sickness, through the Apollo exploration era, and into current planning of exploration missions. The proposed research program takes a new approach which could lead to an effective, practical and acceptable protocol for preadapting astronauts to space flight. By using the gravito-inertial alterations possible with centrifugation in different body orientations the investigators will quantify an individual's sensory adaptation capability and use it to predict and to minimize the consequences of movement in any other gravity environment - eventually including weightlessness. The investigators will also study whether a drug (promethazine) affects motion perception and motion sickness.

Eligibility Criteria:
Inclusion Criteria:

* Subjects must be in general good health

Exclusion Criteria:

* Anyone who is not generally in good general health does not qualify
* Cardiovascular disease
* Severe diabetes
* Respiratory condition (e.g. asthma or emphysema)
* Narrow angle glaucoma
* Prostatic hypertrophy
* Gastrointestinal disorders
Evaluation of Gastric Juice Samples During Standard Gastroscopy Procedure

Development of a new diagnostic detection tool for gastrointestinal bleeding.

Literature does not support enough data/knowledge regarding stomach bleeding Hb levels in pathological situations and/or stomach bleeding levels following biopsy. It is important to understand the approximate concentration level of stomach bleeding before proceeding with technology development to insure this technology is capable of detecting such blood levels.

Eligibility Criteria:
Inclusion Criteria:

* Male or female subjects ≥ 18 years old.
* Subject is scheduled for EGD endoscopy which includes biopsy, or,
* Subject is scheduled for EGD endoscopy following a bleeding event.

Exclusion Criteria:

* Subject is either not competent or not willing to provide written informed consent.
A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Adefovir or Entecavir in Patients With HBeAg-Positive Chronic Hepatitis B

This 3 arm study will assess the efficacy and safety of PEGASYS alone, or in combination with Adefovir or Entecavir in patients with HBeAg positive chronic hepatitis B. Patients will be randomized to receive 1)PEGASYS 180 micrograms sc weekly for 48 weeks + placebo from weeks -4 to 2;2)PEGASYS 180 micrograms sc weekly for 48 weeks + Adefovir from weeks -4 to 2; or 3)PEGASYS 180 micrograms sc weekly for 48 weeks + Entecavir from weeks -4 to 2. Treatment will be followed by 24 weeks of treatment-free follow-up.The anticipated time on study treatment is 1 year, and the target sample size is 100-500 individuals.


Eligibility Criteria:
Inclusion Criteria:

* adult patients, 18-65 years of age;
* HBeAg+ve for \>=3 months;
* positive serum HBV DNA within 3 months prior to entry;
* patients with chronic hepatitis B, either naive to HBV treatment, or not responded/relapsed to nucleoside analogues;
* \>=3 months treatment-free interval from nucleotide analogues.

Exclusion Criteria:

* evidence of decompensated liver disease;
* history or other evidence of a medical condition associated with chronic liver disease othr than viral hepatitis;
* co-infection with active hepatitis A,C or D, or HIV.
Comparison of Two Different Treatment Methods

A number of previous studies investigated the effects of kinesiotaping (KT) in subacromial impingement syndrome (SIS).

Subacromial impingement syndrome (SIS) is characterized by shoulder pain that is exacerbated with especially arm elevation or overhead physical activities.

Eligibility Criteria:
Inclusion Criteria:

* Impingement symptoms in clinical tests
* Pain \>1 month

Exclusion Criteria:

* Any shoulder pathology.
* Have chronic systemic diseases or infections.
* History of any surgery shoulder complex.
* steroid injections and therapeutic approaches
Community-Acquired Pneumonia Diagnosis Through Integrating Novel Microbiological Techniques.

To evaluate novel microbiological techniques for enhanced Pathogen Identification, assess the speed and efficiency of the integrated approach in providing timely diagnostic results, aiming to reduce the turnaround time for CAP diagnosis and subsequently improve patient outcomes and evaluate the clinical impact of enhanced precision in CAP diagnosis on treatment decisions, including the potential for targeted and more effective antimicrobial therapy based on accurate pathogen identification.

Community-acquired pneumonia (CAP) is the term used to describe an acute infection of the lungs that develops outside the hospital setting in a patient who has not been recently hospitalized.

Community-acquired pneumonia (CAP) is one of the most common infectious diseases and is a significant cause of mortality and morbidity globally despite preventative measures aimed at combating CAP.

These measures include pneumococcal vaccination of at-risk groups, yearly vaccinations for seasonal influenza viruses and since 2021, SARS-CoV-2 vaccination.

Understanding the etiology of CAP is crucial for accurate empirical antibiotic treatment, updating treatment guidelines, and future vaccine cost-benefit analyses. Currently, microbiological testing for CAP patients does not identify the etiology of most cases.

In contrast, molecular biology techniques, are rapid and sensitive for the diagnosis of pathogens. Furthermore, a multitude of nascent technologies, including multiplex real-time PCR; that detect multiple respiratory pathogens including both bacteria and viruses from a single respiratory tract sample and microarray methodologies, have become accessible for employment in clinical settings.

Improved diagnostics may change the management of CAP infections ,prompt identification of the appropriate organism would allow antibiotic de-escalation, which would decrease cost, adverse drug effects and antibiotic resistance pressure. These clinical interventions potentially translate to a reduced length of stay and financial savings for the patient, as well as an improved therapeutic outcome.

Eligibility Criteria:
Inclusion Criteria:

* All patients with clinical diagnosis of pneumonia among both sexes
* Age \>18 years Old.

Exclusion Criteria:

* Age \<18 years old.
* Patients who refuse to participate in the study.
* patient who acquire infection after hospital admission within 48 hours.
AcuGraph and Digestive Symptoms

This research is designed to study the reliability of the results of an AcuGraph in college students and faculty members with reported digestive symptoms

The specific aim of the study is to test the reliability of the AcuGraph in subjects with irritable bowel syndrome (IBS). The hypothesis is that the AcuGraph will be a reliable method to identify disorders in subjects.

Eligibility Criteria:
Inclusion Criteria:

* Subjects will be required to answer a questionnaire evaluating for a percentage of digestive disorders "disability" based on the subject's answers. If a participant's answers do not qualify as a disability, they will be assigned to the asymptomatic group and will still be examined with an AcuGraph to provide normative data.

Exclusion Criteria:

* heart condition
* kidney disorder
* thyroid disorders
* diabetes
* chronic disease or illness
* neurological diseases
* skin or bleeding disorders
* pregnant
* currently taking drugs or nutritional supplements
* pacemaker and/or