cyrilzakka/clinical-trials huggingface dataset:
Use of 18F-PSMA-11 PET for Detection of Lesions in Iodine Refractory Thyroid Cancers

Determine the diagnostic value of 18F-PSMA-11 in patients with iodine refractory thyroid cancer.


Eligibility Criteria:
Inclusion Criteria:

* Patient is 18 years or older.
* Signed Informed Consent.
* Subject is diagnosed with a histologically confirmed differentiated thyroid carcinoma, that is considered RAI refractory. There is evidence of persisting or recurrent disease, based on serum thyroglobulin levels and/or medical imaging.
* Subject should have a routine clinical 18F-FDG PET/CT performed within two months prior to the study scan.
* Female patients should be either post-menopausal, surgically sterile, or using highly effective contraceptives (methods that can achieve a failure rate of less than 1%: combined hormonal contraception, progestogen-only hormonal contraception associated with inhibition of ovulation, intrauterine device, intrauterine hormone-releasing system, bilateral tubal occlusion, vasectomized partner, sexual abstinence).

Exclusion Criteria:

* Patient has a known other active malignancy.
* Subject is potentially pregnant (urinary test can be performed in case of doubt) or breastfeeding.
* Patient is mentally or legally incapacitated.
A Human Factor Study To Asses The Usability And Feasibility Of The Peritron+ During Intended Use

In a hospital setting, the self-measurement of intravesical pressure (SMIP) assessment will be conducted at full and empty bladder using the Peritron+ and a ruler-based manometry method. In the home setting a human factor/usability study will be conducted to measure the subject's ability to perform a successful SMIP assessment at full and empty bladder with the Peritron+. This study involves the use of the Peritron+, Air-Trap Tubing, a ruler and a clean intermittent catheter (CIC).


Eligibility Criteria:
Inclusion Criteria:

* Children (2 to 18 years old)
* Subjects who perform CIC regularly
* Must be able to understand English instructions (written or oral)

Exclusion Criteria:

* Subjects suffering from symptomatic bladder infection
Sub Lingual Versus Traditional Oral Administration of Ticagrelor in Acute Coronary Syndrome/Non ST-elevation Myocardial Infarction - A Platelet Reactivity Study

Our goal is to examine sub lingual versus traditional oral administration of ticagrelor in ACS/non ST-elevation Myocardial Infarction (NSTEMI) patients on platelet reactivity.


Eligibility Criteria:
Inclusion Criteria:

1. Patients presenting with ACS/NSTEMI
2. Informed, written consent

Exclusion Criteria:

1. Age \< 18 years or Age \> 90 years
2. Active bleeding; bleeding diathesis; coagulopathy
3. Increased risk of bradycardiac events
4. History of gastrointestinal or genitourinary bleeding \<2 months
5. Major surgery in the last 6 weeks
6. History of intracranial bleeding or structural abnormalities
7. Suspected aortic dissection
8. Any other condition that may put the patient at risk or influence study results or investigator's opinion (severe hemodynamic instability, known malignancies or other comorbid conditions with life expectancy \<1 year)
9. Administration in the week before the index event of clopidogrel, ticlopidine, prasugrel, ticagrelor, thrombolytics, bivalirudin, low-molecular weight heparin or fondaparinux.
10. Concomitant oral or IV therapy with strong CYP3A inhibitors or strong CYP3A inducers, CYP3A with narrow therapeutic windows
11. Known relevant hematological deviations: Hb \<10 g/dl, PLT\<100x10\^9/l
12. Use of coumadin derivatives within the last 7 days
13. Chronic therapy with ticagrelor, prasugrel, clopidogrel or ticlopidine
14. Known severe liver disease, severe renal failure
15. Known allergy to the study medications
16. Pregnancy
17. Human immunodeficiency virus treatment
Graft Patency Outcomes in Patients Undergoing Coronary Artery Bypass Grafting Via Minimally Invasive Coronary Surgery

This clinical study has been developed to evaluate the clinical outcomes in patients undergoing coronary artery bypass grafting via Minimally Invasive Coronary Surgery (MICS); a minimally invasive coronary bypass procedure that is done on a beating heart via a smaller chest incision, thus avoiding the invasiveness of the standard procedure.


Eligibility Criteria:
Inclusion Criteria:

* \> or equal to 18 and \< or equal to 80 years of age
* Suitable minimally invasive coronary surgery (MICS) candidate for non-emergent first time, single or multivessel coronary artery bypass grafting (on pump or off pump)
* Left ventricle ejection fraction \>30%
* Willing and able to provide written informed consent and comply with study requirements

Exclusion Criteria:

* Severe cerebrovascular disease within 90 days of surgery including history of prior stroke.
* Previous cardiac surgery procedures such as CABG revisions, surgical ablations or valve replacements
* Congestive heart failure with a New York Heart Association (NYHA) Class IV
* History of renal insufficiency (i.e. prior serum creatinine of \>2mg/dl) and/or requiring dialysis
* Uncontrolled diabetes (i.e. \>2 serum glucose concentrations of \>350 mg/dl)
* Severe uncontrolled systemic hypertension (i.e. systolic pressure \>160 mmHg)
* Peripheral/systemic active infection excluding the patient from cardiac surgery
* Life expectancy of less than 1 year due to other illness such as cancer or pulmonary, hepatic or renal disease
* Participation in another investigational protocol that may confound the results of this study
* Female of child bearing potential and lactating or intends to become pregnant during the study
* Severe distal disease and small posterior lateral targets
Diagnostic Accuracy of WEARable TECHnology Single-lead ECG in Detecting Cardiac Arrhythmias

Atrial fibrillation (AF) is the most common arrhythmia (irregular heart rhythm), affecting 1-2 million people in the UK. AF significantly increases the risk of an AF-related stroke, heart failure and dementia. A significant proportion of people will have no symptoms, and they may only be found to have AF after suffering an AF-related stroke.

An electrocardiogram (ECG) uses sensors placed on the skin to record the heart's electrical activity. A 12-lead ECG uses 10 sensors and is the gold-standard (best available test) to detect any abnormal heart rhythm disturbances. Until recently, a 12-lead ECG showing an irregular heart rhythm was required to make a diagnosis of AF but as AF episodes are often short and unpredictable it may be missed. Therefore, a small device that continuously records heartbeat and heart rhythm could make the diagnosis of arrhythmias and AF much quicker and easier.

Accessories such as watches or rings - referred to as wearable devices - have extremely good sensors that measure pulse rate by detecting small changes in skin colour during each heartbeat and can perform a single-lead ECG. Algorithms built in the wearable devices can identify irregular heart rhythms, such as atrial fibrillation.

The purpose of this study is to test two new wearable devices - the Skylabs CART-I ring and the Apple Watch - in detecting abnormal heart rhythm recording and recording ECGs. The investigators plan to recruit 500 patients attending Cardiology Departments in several hospitals in the UK and will ask them to wear the Apple Watch and the CART-I and perform 12-lead ECG with each device (two in total). No extra follow-up visits are required. At the end of the study, the investigators will compare interpretation by two cardiologists of the wearable devices' ECGs and the 12-lead ECGs and look at their ability to automatically detect abnormal rhythms.


Eligibility Criteria:
Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the trial.
* Male or female aged 18 years or above.
* Indication for 12-lead ECG.

Exclusion Criteria:

* Unable to comply with instructions.
* Tattoos in the wrists or fingers where the device will be placed.
* Severe skin allergy to silicone (Apple Watch wrist band) or nickel allergies.
EFFECT OF AEROBIC TRAINING VERSUS MYOFACIAL RELEASE ON CLAUDICATION AMONG PREPHERAIL ARTERAIL INSUFFIECENCY PATIENTS

This study is trying to answer the following research question: "Are there any differences between effects of aerobic training and myofascial release on claudication among peripheral arterial insuffiency patients?

Peripheral arterial disease is a systemic disorder and for the most part progressive. The condition is associated with life and limb-threatening complications. Symptoms of PAD range from intermittent claudication-defined as fatigue or discomfort in calf, buttock, or thigh muscles on exertion that is relieved by rest-to critical limb ischemia-defined as distal leg pain at rest with or without ischemic ulcers Despite many advances in endovascular surgery, amputations of digits and limbs are not uncommon. Thus, the present-day approach is to prevent the disorder in the first place. There are many evidences that support changes in lifestyle can significantly decrease the rate of progression of the disease and improve the quality of life in addition to aerobic training exercise and manual therapy .

Eligibility Criteria:
Inclusion Criteria:The patients had been met the following criteria to be involved in this study:

1. Patients from both sexes who were medically diagnosed as peripheral arterial insufficiency with type II claudication at single lower limb 2- Peripheral arterial insufficiency patients, who have ABI inbetween0.90-0.50

1. Age was ranged from 45 -55years.
2. Patients who have intermittent claudicating pain during activities not at rest.
3. BMI between 25-29.9 kg

   -

Exclusion Criteria:

1. patients who was not willing to participate in the study.
2. patients who have severe foot ulcer, and who were diagnosed as Peripheral arterial insufficiency grade III, IV.
3. patients who have the ABI is less than 0.50
4. Patients who have past history of (unstable cardiovascular diseases, marked dyspnea on exertion or with chronic obstructive pulmonary diseases (COPD), liver and kidney diseases).

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Safety and Efficacy of IDP-118 Lotion to Ultravate® in the Treatment of Plaque Psoriasis

Safety and Efficacy of IDP-118 Lotion to Ultravate® Cream, in the Treatment of Plaque Psoriasis

A Phase 2, Multi-Center, Double-Blind, Randomized, Vehicle-Controlled Study to Compare the Safety and Efficacy of IDP-118 Lotion to Ultravate® Cream, in the Treatment of Plaque Psoriasis

Eligibility Criteria:
Key Inclusion Criteria:

* Male or female, of any race, at least 18 years of age (inclusive).
* Freely provides both verbal and written informed consent.
* Has an area of plaque psoriasis appropriate for topical treatment that covers a BSA (Body Surface Area) of at least 3%, but no more than 12%. The face, scalp, palms, soles, axillae, and intertriginous areas are to be excluded in this calculation.
* Is willing and able to avoid prolonged exposure of the treatment area to ultraviolet radiation (natural and artificial) for the duration of the study.
* Has a clinical diagnosis of psoriasis at the Baseline visit with an IGA (Investigators Global Assessment) score of 3 or 4. (The face, scalp, palms, soles, axillae, and intertriginous areas are to be excluded in this assessment, if psoriasis is present.)
* If female and of childbearing potential, must have a negative urine and serum pregnancy test at the Screening visit and negative urine pregnancy at Baseline visit prior to randomization.
* Subject is willing to comply with study instructions and return to the clinic for required visits.

Key Exclusion Criteria:

* Has spontaneously improving or rapidly deteriorating plaque psoriasis or pustular psoriasis, as determined by the investigator.
* Presents with psoriasis that was treated with prescription medication and failed to respond to treatment, even partially or temporarily, as determined by the investigator.
* Presents with any concurrent skin condition that could interfere with the evaluation of the treatment areas, as determined by the investigator.
* Is pregnant, nursing an infant, or planning a pregnancy during the study period.
* Has received treatment with any investigational drug or device within 60 days or 5 drug half-lives (whichever is longer) prior to the Baseline visit, or is concurrently participating in another clinical study with an investigational drug or device.
Interest of Eye Movement Measurements in the Comprehension of Dry Eyes Symptoms

Dry eye syndrome is a benign situation however its impact on patient's quality of live and on health system is not trivial. One problem is the lack of correlation between patient's symptoms and physical sign observed on slit lamp examination. Eye blinking is a parameter of increased interest in this pathology particularly its frequency. To date no treatment of dry eye syndrome has a proven impact on eye blinking frequency. However recording of blinks has mostly been performed on short duration (3 to 5 minutes) and the distribution of intervals between 2 blinks is not gaussian but exponential. In this study, it is proposed to use modern eye-movement recorder to measure the blink frequency on longer duration (12 minutes) while reading on a screen computer and during a face-to-face interview before and after treatment of meibomian gland dysfunction responsible of moderate to severe dry eye syndrome.


Eligibility Criteria:
Inclusion Criteria:

* Moderate to severe dry eye syndrome (Ocular Surface Disease Index\> 30) following a meibomian gland dysfunction
* Not yet properly treated for a meibomian gland dysfunction

Exclusion Criteria:

* History of other ophthalmological or neurological disease
* Pregnant or breastfeeding women
* Patient under 18 years old
* Patient under legal protection
Testing a Provider-Level Feedback Intervention to Optimize Postoperative Prescribing

The objective of this project is to leverage the Michigan Surgical Quality Collaborative's (MSQC) existing network and surgeon performance feedback platform to improve opioid prescribing practices for surgeons within the network found to be prescribing in a manner discordant with published guidelines and to inform best practices for future surgical quality improvement initiatives.

The study is being completed to learn more about the effectiveness, feasibility, and acceptability and that the goal is both to evaluate how effective this intervention and mechanism are for changing surgeon opioid prescribing behavior and to inform best practices for future quality initiatives. The study hypothesizes that provider-level feedback will allow clinicians to tailor postoperative prescribing more closely to patient consumption, and reduce excess postoperative prescribing.

The cohort of surgeons which have been identified as outliers by the Michigan Surgical Quality Collaborative (MSQC) will be be invited to participate in this trial. The study team will send surgeons belonging to sites that signed the Exhibit B-1 form the provider-level push notifications (98 participants). In this study de-identified prescribing data will also be analyzed for sites that do not sign the Exhibit B-1 form (105 participants).

The study team will approach 98 surgeons receiving the provider-level push notifications in one wave.


Eligibility Criteria:
Inclusion Criteria:

* Surgeons already participating in and sharing data with the Michigan Surgical Quality Collaborative (MSQC) who perform procedures of interest
* Surgeons within MSQC who have median prescribing \> 1 pill equivalents over the published recommendation
* Surgeons within MSQC who perform surgeries at a hospital that have agreed to participate in this research

Exclusion Criteria:

* Surgeons not identified in the MSQC data as having a valid National Provider Identifier (NPI)
The Effect of Non-invasive Brian Stimulation on Language Production in Healthy Older Adults

The use of non-invasive brain stimulation techniques like transcranial direct-current stimulation (tDCS) for rehabilitation of language is a growing field that needs further studies to determine how best it can be used to enhance treatment outcomes. It has been shown that tDCS can improve language performance in healthy and brain-injured individuals such as increased naming accuracy.

However, at present, it is not known what effect tDCS has on higher-level language skills like discourse production (i.e. story telling, giving instructions) in healthy, older speakers. Therefore, the aim of this study is to investigate in healthy older adults, the effect of tDCS on discourse production as well as the ideal tDCS electrode placement for improving language at the discourse level. It is hypothesised that tDCS will result in greater language changes and improvements during discourse production compared to no stimulation.


Eligibility Criteria:
Inclusion Criteria:

* At least 65 years of age
* Native English speakers
* Right handed
* Normal aided or unaided visual acuity
* At least secondary school level of education

Exclusion Criteria:

* History of neurological disease or cognitive impairment
* Any contraindication of tDCS (i.e. history of seizures, metal implants)
Evaluation of Difficult Airway With Ultrasonography

As a result of anatomical and physiological changes in obese patients, airway management can be challenging. Ultrasound measurement of neck anterior soft tissues combined with recommended predictive tests may increase the ability to predict the difficult airway. In this study we planned to evaluate the measurement of neck anterior soft tissues by ultrasound in obese patients before anesthesia induction to anticipate difficult mask ventilation, difficult laryngoscopy, and intubation.

Patients with BMI\> 30, schedule elective surgery under general anesthesia, and give consent will be included in the study. In the preoperative evaluation, demographic data of the patients, airway physical examination results (mouth opening, Mallampati score, thyromental distance, neck circumference (from thyroid cartilage level), abnormal upper tooth presence, neck movement restriction\], presence of sleep apnea and STOP-BANG score will be recorded. In the patients taken on the operation table with supine position, ultrasound-guided soft tissue distances will be measured using ultrasound 6-13 Hz linear probe. The distance between the hyoid bone-skin (DSHB), the vocal cord anterior commissura-skin distance (DSAC), the minimum distance of the trachea to the skin at the level of the suprasternal notch (DST), the distance between the thyroid isthmus and the skin (DSI), and the distance between the epiglottis and the skin (DSE) will be measured and recorded. After standard monitoring and anesthesia induction, difficult mask ventilation will be evaluated with Han Scale \[(1) can be ventilated with a mask; 2) can be ventilated with the airway (with or without muscle relaxation); 3) difficult mask ventilation (insufficient, unstable, two practitioners are needed); 4) cannot be ventilated by mask\] and grade 3-4 will be recorded as difficult mask ventilation. Difficult laryngoscopy will be evaluated with Cormack Lehane Scale \[grade 1: vocal cords appear; grade-2: posterior commissura and epiglottis visible; grade-3: only epiglottis are seen; grade-4: glottic structures are not visible\] and grade 3-4 will be recorded as difficult laryngoscopy. Difficult intubation will also be evaluated with the number and duration of intubation attempts with the Macintosh blade. Tracheal intubation will be performed by an anesthesiologist who has at least two years of experience and unaware of ultrasound measurements. The duration of intubation (the time from the first handling of the laryngoscope until the capnography trace appeared) and the number of trials will be recorded.

Eligibility Criteria:
Inclusion Criteria:

* Patients planned to undergo general anesthesia for elective surgery
* American Anesthesiology Association physical classification (ASA) status I-III
* Body mass index (BMI) above 30

Exclusion Criteria:

* Patients with neck mass
* History of previous neck and thyroid surgery, trauma, arthritis, loss of teeth
* History of difficult intubation
* Bearded patients
* Pregnant women
The Study of Pharmacological Treatment Pattern for Cannabis-induced Psychosis

A cross-sectional and retrospective chart review study was conducted at the Princess Mother National Institute on Drug Abuse Treatment (PMNIDAT), Thailand. All patients who admitted at PMNIDAT from October 2013 to September 2019 were included. Patients aged 18-65 years who met the International Classification of Disease-10 (ICD-10) criteria of CIP and Had a positive urine test of cannabis were included. Cannabis use is a component cause of psychosis.More than half of symptoms of cannabis-induced psychosis (CIP) were hallucination, delusion, irritable and anxiety. Antipsychotic drug was still a key psychotropic drugs for treatment of CIP. However, antidepressants and benzodiazepines were commonly used for treatment of other symptoms beyond psychotics


Eligibility Criteria:
Inclusion Criteria:

* Patients ≥ 12 years of age
* Patients who had been diagnosed as Cannabis-induced psychosis by International statistical Classification of Disease and Related Health problem (ICD-10) on 2016 code F12.5
* Patients had history of use of cannabis in medical chart
* Patients had the positive urine screening test of cannabis at the first day of admission

Exclusion Criteria:

* Patients had psychosis from organic psychosis, defined by diagnosis by ICD-10 code F09.6
* Unavailable data for evaluate of outcome especially data of drug use, content of drug use or urine screening test
* Patients who cancel of medical treatment before 7 day after admission.
Comparative Clinical Study for Two Types of Locator Attachments for Mandibular Implant Supported Overdenture

This study aims to evaluate the clinical and radiographic outcomes for mandibular implant-supported overdenture using two different types of locator attachment after 3 years of using the two types of locator attachments


Eligibility Criteria:
Inclusion Criteria:

* 1. All selected patients have two implants placed in the mandibular interforaminal region.

  2. All selected patients have a healthy mucosa and with no clinical complications.

  3. All patients are cooperative and approve the proposed treatment protocol

Exclusion Criteria:

* 1. Patients who reject to participate in the study. 2.Patients who need implant placement as a result of previous implant failure
Phone Intervention for Alcohol (ETOH) Use in Emergency Department Motor Vehicle Crash (ED MVC) Patients

The purpose of this study is to determine if a brief counseling intervention, delivered by telephone, is more effective than standard ED care, to reduce future alcohol related injuries and alcohol related negative consequences, among patients treated in the ED for injuries from an MVC and other injury mechanisms.

Alcohol related motor vehicle crashes (MVC) continue to be a substantial public health problem. Brief interventions for alcohol (BI) for injured ED patients have been demonstrated to be effective, and perhaps more so for MVC patients.

Telephone interventions have been utilized in varying ways in health care. We compared the delivery of two brief interventions by telephone against an assessment only condition. Participants who received the BI and the assessment only condition were contacted 3 and 12 months after recruitment. Data about alcohol use, injuries and high risk behaviors, including drinking and driving behaviors were collected at the 3 and 12 month follow-up assessments.

Eligibility Criteria:
Inclusion Criteria:

* 18 years or older
* Emergency department patient
* Subacute injury
* Motor vehicle crash or other injury
* Alcohol use at harmful and hazardous levels

Exclusion Criteria:

* Younger than 18 years old
* Does not meet alcohol use criteria
* Non-English speaker
* In police custody
* Suicidal
* Psychiatric diagnosis
* No locator
* Injury occurred \> 72 hours prior to ED visit