cyrilzakka/clinical-trials huggingface dataset:
Eating Phenotypes for Childhood Obesity in the Context of Familial Obesity Risk

Using an integrated approach, this study examines multiple eating traits concurrently under states of hunger and satiety. It examines the impact of short-term appetite and intake regulation on longer-term energy intake control and weight development in a cohort of ethnically diverse normal-weight and obese boys and girls with different familial predispositions to obesity.


Eligibility Criteria:
Inclusion Criteria:

* 7-9 years of age
* Normal-weight or overweight/obese who are at low risk or high risk for obesity based on maternal BMI
* Like most foods served during the study
* Be regular breakfast eaters

Exclusion Criteria:

* Have serious medical conditions known to affect food intake or body weight
* Have any developmental, medical, or psychiatric conditions that might impact study compliance
* Have a learning disability or poor reading ability/comprehension
* Have visual or auditory impairment
* Are taking medications associated with developmental, medical, or psychiatric disorders or medications known to affect appetite, food intake or body weight
* Are underweight
* Have food allergies related to the foods served in the study or are lactose intolerant
* Do not regularly eat breakfast
* Do not like or cannot eat foods served during experimental meal or are unable to finish compulsory preload
* Mothers who are pregnant
Buccal Midazolam Versus Intranasal Dexmedetomidine Plus Oral Chloral Hydrate in Inguinal Hernia Repair

Inguinal hernia surgery is one of the most common surgical procedures in early infancy. Preoperative anxiety remains a vexing issue, and it exists in nearly 50% of pediatric patients

Inguinal hernia surgery is one of the most common surgical procedures in early infancy. Preoperative anxiety remains a vexing issue, and it exists in nearly 50% of pediatric patients.

The administration of sedatives to a child before entering a surgical room is the most common way of reducing the child's distress and allows the child to undergo smooth anesthesia induction.

Chloral hydrate is a widely used sedative for young children undergoing imaging studies, with a high success rate.

Dexmedetomidine is a highly selective alpha-2 agonist for paediatric sedation. It produces sedation like natural non-rapid eye movement sleep and has respiratory-sparing effect.

Eligibility Criteria:
Inclusion Criteria:

* aged 2 to 7
* American Society of Anaesthesiology (ASA) І and П scheduled for inguinal hernia repair

Exclusion Criteria:

* sensitivity to dexmedetomidine or midazolam,
* infection of the upper respiratory tract,
* severe liver or kidney disease, organ dysfunction,
* cardiac arrhythmia or congenital heart disease
Investigation of the Accuracy of Temporal Artery Thermometers

The purpose of this study is to determine whether temporal artery thermometers are accurate tools in temperature measurements of patients presenting to the Emergency Department. The investigators´ hypothesis is that there is a difference of \> 0,3 degrees centigrade (Bland-Altman) between the temperatures measured with the temporal artery thermometers used at the investigators´ hospital (Exergen TAT-5000) and those measured with rectal thermometers (OMRON MC-341-E), which is considered to be the gold standard in Denmark defined by the Danish Center for Clinical Guidelines. The investigators furthermore hypothesize that the difference between these measurements is greater if measured in a patient with hyperthermia (temperature \> 37,9 degrees Centigrade).

Accurate temperature measurement on patients presenting to the Emergency Department is of great importance since it has significant influence on the further treatment of the patient. At Bispebjerg Hospital temporal artery thermometers are being implemented as they provide a fast and comfortable temperature measurement compared to rectal thermometers, who are considered to be the gold standard, defined by the Danish Center for Clinical Guidelines. The scientific proof for their accuracy compared to rectal thermometers in adult patients is insufficient though. The purpose of this study is to determine the difference between temperatures measured by a temporal artery thermometer (Exergen TAT-5000) and a rectal thermometer (OMRON MC-341-E) in patients presenting to the Emergency Department at Copenhagen University Hospital: Bispebjerg. The investigators hypothesize that there will be an average difference of at least 0,3 degrees centigrade between those two types of measurements (Bland-Altman). Based on a significance of 5% and a power of 80% the number of patients was calculated to 385, including an estimated 10% dropout.

Eligibility Criteria:
Inclusion Criteria:

* given informed consent

Exclusion Criteria:

* constipation
* anal disorders
Functional Movement Analysis (FMS) of Diaphragmatic Breathing-Immediate Effect on Shoulder Mobility

The diaphragm is defined as a thin, smooth muscle that separates the thoracic and abdominal cavities. The shoulder and diaphragm muscle have a clear relationship through innervation and myofascial tissue connection. Fascia is often neglected medically, rehabilitatively, or performance as the underlying cause of problems. Bones, organs, and muscles appear to float in the fascial web, a continuous three-dimensional system of connective tissue. Plastic and viscoelastic properties, which can change tension and shape under the influence of manual techniques and movement retraining, ensure that the structural changes are reversible. Functional Movement Analysis (FMS) is a screening system that aims to predict the risk of injury and functional deficiencies. FMS consists of 7 basic motion component tests. It is scored on a scale of zero to three and creates a composite score whose sum ranges from 0 to 21 points. One of the 7 motion models evaluated is shoulder mobility. According to the results of this study, people who perform activities that require shoulder mobility will be guided as to whether the use of diaphragmatic breathing will be effective for preparation, rehabilitation or performance improvement. The aim of the study was to observe whether shoulder mobility increased in healthy individuals taught diaphragm breathing compared to the control group.


Eligibility Criteria:
Inclusion Criteria:

* Volunteer to participate in the study
* Individuals between the ages of 18-30

Exclusion Criteria:

* Have a musculoskeletal injury/operation involving the shoulder area in the last 6 months
* Using drugs that can affect the respiratory system
* Have received aerobic exercise training in the last 6 weeks
Original Protocol of Oral Cavity Care During Long-term Mechanical Ventilation

This is a prospective open label randomized controlled trial of the efficacy of original oral care protocol for prevention of ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT)in adult patients mechanically ventilated for at least 3 days

The study aims to clarify the effect of of the original method of oral cavity care in adult patients of intensive care units on long-term mechanical ventilation due to the assessment of the microbiological landscape of the oral cavity, oral plaque, upper and lower respiratory tract, the incidence of ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT) , depending on the traditional or original protocol of the oral cavity care. Ventilator associated pneumonia is associated with significant morbidity and mortality.Inadequate oral hygiene in intensive care units (ICUs) has been recognized as a critical issue, for it is an important risk factor for ventilator associated pneumonia (VAP). VAP is an aspiration pneumonia that occurs in mechanically ventilated patients, mostly caused by bacteria colonizing the oral cavity and dental plaque. It has been suggested that improvement of oral hygiene in ICU patients could lead to a reduced incidence of VAP. Although diverse oral care measures for ICU patients have been proposed in the literature, there is no evidence that could identify the most efficient ones. Although there are several evidence-based protocols, oral care measures are still performed inconsistently and differ greatly between individual ICUs.The influence of tooth brushing to maintain good oral health in the general population has long been standard practice. However the effect of brushing in the mechanically ventilated and intubated critically ill patients to dislodge organisms from dental plaque remains largely unclear

Eligibility Criteria:
Inclusion Criteria:

1. Age of 18 years or more;
2. Mechanical ventilation more than 24 hours;
3. Expected length of mechanical ventialtion more than 72 hours;

Exclusion Criteria:

1. Aspiration at the prehospital stage
2. Community-acquired pneumonia
3. COPD or specific lung diseases
4. Сhest Injury
5. Hemo and \\or pneumothorax
6. Fat embolism
7. Lung cancer
8. Severe renal and\\or hepatic impairment
9. Blood platelets less than 50 000 / μl
10. Pregnancy and the period of breastfeeding;
11. Other circumstances that the researcher considers inappropriate to participate in this study
Neuro Imaging and Multimodal Alzheimer's Disease

The present study aimed at measuring cerebral changes in Alzheimer Disease (AD) patients, who responded to strict physiological criteria typical of AD pathology. The objective of the present study was to identify the earliest alterations in cerebral connections that could contribute to the initial episodic memory impairment.


Eligibility Criteria:
Inclusion Criteria:

For all subjects :

* Capacities visual, auditory (authorized devices) and oral or written expression sufficient for the proper performance of tests
* Obtain informed written consent of the subject

Patients with AD :

* Outpatient accompanied by a "helping"
* No parenchymal lesions allowing isolation explain the symptoms on brain MRI (T1 and T2) carried more than 6 months prior to enrollment in the study. Patients with more than three hyperintense white matter or visible lacunar infarction or T2 FLAIR will not be included in the study.
* probable Alzheimer's disease diagnosis par with international standards
* Illness in a mild stage (CDR 1, 24 ≥ Mini-Mental State Examination (MMSE)\> 18)
* activity of daily living (ADL) 4 items\> 1/4

Patients with Alzheimer's disease at a pre-dementia stage:

* Alzheimer's Diagnosis pre-dementia based on the search criteria
* Illness in a mild stage (CDR 0.5, 30 ≥ MMSE ≥ 25)
* ADL items ≤ 4 1/4

Control subjects :

* 30 ≥ MMSE ≥ 27
* perfect autonomy in daily living (IADL = 0, CDR = 0)
* Neuropsychological evaluation not highlighting of impaired cognitive performance with focus on memory performance
* No parenchymal lesions on brain MRI.
* Lack of family history (first degree) of Alzheimer's disease

Exclusion Criteria:

* Subjects with a contra-indication to MRI (carrying a pacemaker or cardiac defibrillator, implanted a material activated by an electrical, magnetic or mechanical carriers hemostatic clips intracerebral aneurysms or carotid artery , holders of orthopedic implants, claustrophobia)
* Subjects with clinically significant gastrointestinal, renal, hepatic, endocrine, or cardiovascular
* Subjects with a psychiatric disorder or progressive neurological
* French Language level insufficient to be appropriately involved in neurophysiological evaluation
* less than 5 years Education (insufficient understanding level to participate in the study)
* Administrative problems: unable to give informed about information, not covered by a social security system
* Hypersensitivity to the active substance or to any of the excipients
* unbalanced diabetes mellitus
* Subjects treated by a non-steroidal anti-inflammatory
Renal Magnetic Resonance (MR) Elastography in Healthy Volunteers

MR Elastography is a new technique aimed at non-invasively measuring the stiffness of tissues. It has recently given interesting results in the assessment of liver fibrosis.

The objectives of the current study are:

1. to develop an imaging protocol for MR Elastography of the kidneys;
2. To calculate the stiffness of normal kidneys;
3. To evaluate the variability of the measurements of kidney stiffness by repeating the procedure twice on the same volunteers.


Eligibility Criteria:
Inclusion Criteria:

* Age between 18 and 40
* Signed informed consent form
* Insured by the French Social Security

Exclusion Criteria:

* Pregnancy
* Personal or familial history of kidney disease
* Hypertension
* Diabetes
* Contraindication to MRI
Efficacy and Safety of Single-session Endoscopic Stone Extraction

This is a retrospective study, including approximately 600 patients with acute cholangitis accompanied with choledocholithiasis, who treated with single-session or two-session endoscopic stone extraction at Beijing friendship hospital. The investigators assessed the outcomes of single-stage and two-stage endoscopic stone extraction.

Acute cholangitis is an acute inflammation caused by obstruction of the bile duct, of which choledocholithiasis is the most common cause. Without timely removal of the obstruction or control of the infection, cholangitis can get worse and even become life-threatening. Therefore, timely and effective treatment is essential for patients with acute cholangitis combined with choledocholithiasis. Endoscopic retrograde cholangiography (ERCP) is used as the first-line treatment for choledocholithiasis-associated acute cholangitis. Previous guidelines recommended two-session endoscopic therapy. Endoscopic biliary drainage as the initial treatment, followed by endoscopic stone extraction after cholangitis improved. In recent years, studies have found that single-session endoscopic stone extraction is safe and effective for patients without serious organ function impairment. Meanwhile, single-session endoscopic lithotomy can avoid the second ERCP intervention, which can relieve the pain of patients, reduce medical costs and shorten the length of hospital stay. However, there is still insufficient evidence on the effectiveness and safety of early single-session ERCP lithotomy. The aim of this study is to evaluate the efficacy and safety of single-session endoscopic stone extraction for acute cholangitis associated with choledocholithiasis, so as to provide reference of clinical treatment.

In a retrospective analysis, approximately 600 patients with acute cholangitis accompanied with choledocholithiasis, who treated with single-session or two-session endoscopic stone extraction at Beijing friendship hospital were studied. The investigators assessed the outcomes of single-stage and two-stage endoscopic stone extraction.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥18 years old
2. Patients met the Tokyo Guidelines 2018 (TG18) diagnosis of acute cholangitis
3. Imaging examination confirmed the presence of choledocholithiasis
4. Patients received endoscopic single-session stone extraction or two-session treatment involving stone removal after drainage

Exclusion Criteria:

1. Common bile duct with benign or malignant stenosis
2. Changes in the anatomical structure of the stomach or duodenum
3. Patients complicated with severe acute pancreatitis
4. Patients who underwent endoscopic intervention before admission
5. Patients received percutaneous transhepatic cholangio drainage (PTCD) or other invasive interventions besides endoscopic treatment
VasoStar Vibrational Guidewire System to Facilitate Crossing Coronary Artery Chronic Total Occlusions

The goal of this project is to provide an improvement in wire performance to expedite crossing difficult lesions in the coronary vasculature.

This Early Feasibility Study (EFS) is proposed to evaluate the initial safety and efficacy of the VasoStar guidewire system to cross complex coronary vascular lesions in non-tortuous arterial segments which are resistant to crossing with a traditional interventional guidewire.

Eligibility Criteria:
Inclusion Criteria:

* Male or female, over 18 years of age, presenting with at least one ischemia inducing lesion in a native coronary artery that is refractory to standard guidewire crossing. Chronic total occlusion (CTO) is defined as 100% coronary blockage for over a 3-month duration documented either by prior catheterization or by clinical evaluation
* Suitable candidate for non-emergent, coronary angioplasty
* Documented de-novo or restenotic coronary chronic total occlusion defined as a lesion with TIMI 0 flow for at least 90 days refractory to conventional guidewire crossing
* Left ventricle ejection fraction \> 20% within the last 12 months.
* For antegrade chronic total occlusion procedures, activated clotting time (ACT) should be \> 300 sec
* Chronic total occlusion in a non-tortuous arterial segment
* Voluntarily sign a Patient Informed Consent Form specific to the study.
* Physically and mentally willing to comply with all study requirements.

Exclusion Criteria:

* Successful target lesion crossing with a conventional wire system prior to enrollment
* Prisoners.
* Pregnancy
* Patient has an active implantable.
* Extensive dissection created by refractory guidewire
* Severe ongoing congestive heart failure (New York Heart Association Class IV symptoms)
* Active infection
* Uncontrolled Hypertension (Systolic blood pressure \> 180 mm) at the time of the procedure
* History of severe reaction to contrast media
* Recent myocardial infarction (within 2 weeks)
* In-stent target lesion
* Severe cerebrovascular disease including history of prior stroke or transient ischemic attack within 1 month at the time of the procedure
* Saphenous vein graft (SVG) chronic total occlusion or an in-stent chronic total occlusion
* Short life expectancy due to other illnesses such as cancer or pulmonary, hepatic or renal disease
* Participation in another investigational protocol at the time of the procedure
Efficacy and Safety Study of Ginseng Polysaccharide Extract

Y-75/ginsan is an acidic polysaccharide with a molecular weight of 150,000 Da, isolated from the aqueous Korean Panax ginseng extract. Preclinical laboratory studies have shown its function as an immunomodulatory molecule. The present study performed to evaluate the safety and beneficial effects of Y-75 on immune function in a group of healthy adults.

The focus of this trial was modulation of innate immunity, comprising cytotoxic activity of natural killer cells, phagocytic activity of polymorphonuclear leukocytes and mononuclear phagocytes, and serum levels of monocyte-derived mediators.


Eligibility Criteria:
Inclusion Criteria:

* Good general health

Exclusion Criteria:

* human immunodeficiency virus-1 infection
* malignancy
* active cardiovascular, renal, pulmonary, hepatic, neurological, psychiatric disease
* recent (within 4 weeks) acute respiratory tract symptoms
* immunosuppressive therapy including cytotoxic agents and corticosteroids
* medication (within 4 weeks) deemed likely to interfere with the evaluation
* history of allergic or other adverse reactions to ginseng products
Impact of Music in the Preoperative Stress of Children Undergoing General Surgery

Preoperative anxiety and stress are present in up to 60% of pediatric patients undergoing surgery, having a great physiological and emotional impact on children in both the short and long term. There are many reports on the use of music therapy in the perioperative period as a complementary technique in the preoperative stress and anxiety management. However, there are no assessments of the effect of this intervention on the physiological variables, such as salivary cortisol.

60 patients aged 5-7 years, ASA (American Society of Anesthesiologists) status I-II, scheduled for general surgery at the Hospital of the Catholic University and associate institutions, will be considered for inclusion. 30 will receive music as intervention and 30 will received usual treatment. Salivary cortisol samples will be obtained preoperatively, in the surgical ward (OR), and in the post-anesthesia care unit (PACU). Secondary outcomes will be M-YPAS (Yale Preoperative Anxiety Scale) for children, and STAI (State-Trait Anxiety Inventory) for parents scales.

Eligibility Criteria:
Inclusion Criteria:

* Elective surgery
* ASA I-II
* Parents' consent

Exclusion Criteria:

* History of endocrine diseases (hypothyroidism, treatment with growth hormone, severely obese)
* Taking glucocorticoid inhalers or oral corticosteroids
* Children with severe hearing problems
* Patients requiring emergency surgery
* Refusal to participate in the study
Cognitive-Behavioral Therapy for Disruptive Behavior in Children and Adolescents

This is a randomized controlled study of cognitive-behavioral therapy (CBT) for disruptive behavior such as irritability, anger and aggression in children and adolescents. CBT will be compared to Supportive Psychotherapy (SPT) and participants of this study will be randomly assigned (like the flip of a coin) to receive CBT or SPT. Participants will be also asked to complete functional magnetic resonance imaging (fMRI) and electrophysiological (EEG) tasks (recordings/images of brain activity) before and after treatment.

Cognitive-behavioral therapy (CBT) is a behavioral intervention that consists of 12 weekly sessions. During CBT children are taught various skills for coping with frustration and parents are taught various strategies for managing situations that can be anger provoking for their child. This study is conducted to examine whether reduction of behavioral problems including anger outbursts, irritability, aggression and noncompliance after CBT may be paralleled by changes in areas of the brain responsible for emotion regulation and social perception.

Eligibility Criteria:
Inclusion Criteria:

1. Boys and girls, 8 to 16 years of age.
2. T-Score \> 65 on the parent-rated Aggressive Behavior Scale of the Child Behavior Checklist (CBCL).
3. Unmedicated or on stable medication for aggression, ADHD, anxiety, or depression for at least 6 weeks, with no planned changes for duration of study.
4. Children can speak English sufficiently enough to participate in CBT and study assessments.
5. Children should have 1) no metal medical implants, 2) a body weight of less than 250 lbs. and 3) no claustrophobia. \[These are necessitated by the safety requirements of the fMRI.\]
6. Children should be able to meet fMRI data quality requirements at baseline \[to enable pre- to post-treatment comparison.\]
7. Families can commute to the Yale Child Study Center in New Haven, CT for weekly visits.

Exclusion Criteria:

1. IQ below 85.
2. Children across various DSM diagnoses will be eligible for participation. However, significant levels of psychopathology that require immediate clinical attention such as severe depression or psychosis will be exclusionary because it will require alternative treatments.
3. Significant medical condition such as heart disease, hypertension, liver or renal failure, pulmonary disease, seizure disorder, brain injury based on medical history which can interfere with participation in the study.
4. Concurrent psychotherapy can continue, but CBT for aggression is exclusionary. Subjects will be asked not to initiate any new child psychotherapy during the study.