cyrilzakka/clinical-trials huggingface dataset:
Effectiveness of Video-based Yoga Practices for Sedentary Women in Pandemic Days

This is an observational study aiming to Examine the effects of video-based yoga compared to face-to-face yoga and physical exercise practices on the physical features, respiratory capacity and sleep quality of sedentary women in pandemic days.

The pranayama (respiration), asana (poses), and meditation were given to the face-to-face yoga group, and the same exercises of the face-to-face yoga group were recorded in the video for the video-based yoga group. The exercises for respiration, muscle strengthening, stabilization, and flexibility were given face-to-face to the physical exercise group.

This is an observational study aiming to Examine the effects of video-based yoga compared to face-to-face yoga and physical exercise practices on the physical features, respiratory capacity and sleep quality of sedentary women in pandemic days.

The respiration, poses, and meditation were given to the face-to-face yoga group, and the same exercises of the face-to-face yoga group were recorded in the video for the video-based yoga group. The exercises for respiration, muscle strengthening, stabilization, and flexibility were given face-to-face to the physical exercise group. The sessions for each group were given for a total of 6 weeks (2days/week) as 12 sessions, and 60 min. Their respiration (spirometer Pony-Fx), sleep (Pittsburgh Sleep Quality Index), posture (New York Posture Rating Chart), balance (Single Leg Stance Assessment, Functional Reach Distance), functional strength (5X Sit-to-Stand test), fatigue (Fatigue Severity Scale) and quality of life (WHOQOL-BREF) were evaluated at the beginning and end of the 6 weeks. The data were assessed statistically.

Eligibility Criteria:
Inclusion Criteria:

* being between the age of 18 - 60 years,
* not having any history of a systemic disease, such as musculoskeletal or neurological problems, cardiac or lung diseases, diabetes and no history of recent surgery
* not having participated in a regular exercise program in the last 6 months and
* not having a history of active sports engagement

Exclusion Criteria:

* not being voluntary to join the study and
* missing more than three sessions during the study period
Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.

The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.

Eligibility Criteria:
Inclusion criteria:

* Emergency surgery:

  1. Vascular
  2. Intra-abdominal
  3. Orthopedic

     Exclusion Criteria:
* Patients unable to provide informed consent
* Thoracic surgery
* Trauma surgery
Incidence of Descemet Membrane Detachment Post GATT by AS OCT

detection of Incidence of Descemet membrane detachment post gonioscopy-assisted transluminal trabeculotomy by anterior segment optical coherence tomography in patients with open angle glaucoma.

In our study, which should include 30 eyes with OAG who underwent 360 GATT Screening for Descemet Membrane Detachment will be done by Anterior Segment Optical coherence Tomography using SD-OCT: Optovue RTVue (Optovue Inc., Fremont, CA, USA) for the angle day 1 post operative for all patients and 1 week post operative in cases with Descemet membrane detachment to check for spontaneous resolution.

One month post-operative the patients underwent

* Best corrected visual acuity (BCVA) using decimal.
* IOP measurement using GAT.

Eligibility Criteria:
Inclusion Criteria:

1. Age 18 - 70 years.
2. Patients with open angle glaucoma undergoing gonioscopy assisted transluminal trabeculotomy.

Exclusion Criteria:

1. Patients with with open angle glaucoma and aphakia.
2. Patients with Congenital Glaucoma.
3. Patients with open angle glaucoma undergoing phaco -gonioscopy-assisted transluminal trabeculotomy.
4. Patients with neovascular glaucoma.
5. Patients with pigmentary Glaucoma.
Immediate Effects of Stepping Training Using External Feedback in Spinal Cord Injury Patients

* Does stepping training with or without external feedback change functional ability of ambulatory patients with iSCI immediately after training?
* Are there significant differences between the immediate effects of stepping training with or without external feedback in ambulatory patients with iSCI?

To compare immediate effects of stepping training with or without the utility of external feedback on functional ability relating to walking in ambulatory patients with iSCI (between-group comparison).

Secondary objective To compare immediate effects in a group of stepping training with or without the utility of external feedback on functional ability relating to walking in ambulatory patients with iSCI (within-group comparison).

Eligibility Criteria:
Inclusion Criteria:

* Independent ambulatory patients with iSCI at a chronic stage (Post-injury time \> 12 months)
* Traumatic cause or non-progressive disease
* Independent walking with or without assistive devices at least 17 meters (Functional Independence Measure Locomotor (FIM-L) scores 5-7)
* Age at least 18 years
* Body mass index (BMI) between 18.5 - 29.9 kg/m2.

Exclusion Criteria:

* Any conditions or disorders that might affect ability to participate in the study and/or ambulatory ability of the subjects such as

  * Brain function disorders
  * Visual deficits that cannot be corrected using glasses or contact lens
  * Musculoskeletal pain (with an intensity of pain more than 5 out of 10 on a numerical rating pain scale)
  * Deformity of the musculoskeletal system
  * Unable to follow a command of the tests
  * Unstable medical conditions
  * Color blindness
The ROAM Research Study Therapy (LTOT) Version

The purpose of this research is to test a device being developed that can see how patients use oxygen therapy over a long period of time. This study will focus on developing a new display part called ROAM module which will be attached to your oxygen source. The display will provide easily-accessible information that can show how you interact with your supplies and the oxygen machine automatically without connecting the oxygen source to the internet or other devices.

The Respiratory Oxygen Adherence Monitor (ROAM) system objectively determines the duration and pattern of adherence to oxygen therapy on a minute-by-minute basis and provides feedback of usage metrics to patients and their clinicians. The purpose of the ROAM monitor is, ultimately, to improve the clinical management of patients with chronic obstructive pulmonary disease (COPD) and patients requiring long-term oxygen therapy (LTOT), to improve health outcomes in these patients, and to reduce costs that arise from the expensive and preventable exacerbations associated with patient non-adherence. The prevalence of COPD poses an enormous burden to the U.S. healthcare system. LTOT is a well-established treatment for patients with oxygen desaturation due to COPD and other cardiopulmonary diseases. The benefits of adequate adherence to LTOT are substantial both to COPD patients (in terms of reduced morbidity and mortality) and to society (in terms of healthcare cost savings). Despite these benefits, patient adherence to LTOT remains poor. The lack of a method to objectively and reliably quantify LTOT usage complicates the challenge of managing these patients. Furthermore, current adherence metrics (e.g., power-on time) fail to provide information regarding the timing of oxygen use within each 24-hour interval. The ROAM system combines several unobtrusive sensing modalities with adaptive algorithms that detect breathing. In this study, the team will develop a patient-ready product prototype targeted at improving patient LTOT adherence.

Eligibility Criteria:
Inclusion Criteria:

Post-Bronchodilator FEV1/FVC \<.80

* Race demographics of the recruitment area reflect the population of the Charlottesville Metropolitan Statistical Area (MSA).
* Due to underrepresentation in local demographics, special effort (via targeted advertising) will be made to recruit Hispanic participants to better match national percentages.
* Participants with medical history of COPD
* Subjects has to have a prescription for oxygen use via nasal cannula or mask at home
* At baseline of health with no hospitalization/exacerbation within the past 6 weeks
* Use of Continuous oxygen at baseline

Exclusion Criteria:

Post -Bronchodilator FEV1 \< 25%

* Intermittent oxygen use at home
* Inability to understand simple instructions
* No respiratory infections and exacerbation within 6 weeks of study
Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment

This study involves the comparison of two treatment approaches for patients with chronic pain who are entering methadone maintenance treatment (MMT) for opioid addiction: (a) an integrated counseling that addresses both chronic pain and opioid dependence(POD)and (b) a counseling intervention that addresses opioid dependence only.


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* prescription opioid or heroin addiction
* moderate to severe chronic pain
* enrolled in methadone maintenance at the APT Foundation for opioid addiction
* understand English

Exclusion Criteria:

* current suicide or homicide risk
* life-threatening or unstable medical problem
Study Of SU011248 In Combination With Paclitaxel/Carboplatin In Patients With Advanced Solid Tumors

The purpose of this study is to test SU011248 (sunitinib) in combination with paclitaxel/carboplatin. This combination regimen will be tested for safety and antitumor activity.


Eligibility Criteria:
Inclusion Criteria:

* Histologically or cytologically proven diagnosis of any advanced solid malignancy that is not amenable to treatment with curative intent
* Candidates for treatment with carboplatin and paclitaxel with maximum of 2 prior chemotherapy regimens
* ECOG performance status 0 or 1

Exclusion Criteria:

* Prior chemotherapy, radiation therapy or surgery within 4 weeks prior to study entry except palliative radiotherapy to non-target, metastatic lesions
* Diagnosis of any second malignancy within the past 3 years
Physical Capacity in Hodgkin Lymphoma Survivors

The study aims to investigate if physical capacity obtained in the cardiopulmonary exercise test can predict cardiovascular alterations in Hodgkin Lymphoma (HL) Survivors. In addition, to study the effects of exercise training on physical capacity and cardiovascular responses in these patients.

Hodgkin Lymphoma (HL) is a hematological neoplasia that mainly affects young people. Anthracycline-based chemotherapy, followed or not by mediastinal radiotherapy, substantially improves prognosis in this set of patients. Observational studies have shown that cardiovascular disease is the most non oncologic cause of death in this population. Coronary artery disease (CAD) affects 26% of survivors after 10 years of absence of HL . However, the early intervention and the assessment to predict the cardiovascular risk remain little known. In this study, the investigators will test the hypothesis that physical capacity can predict the cardiovascular alterations in HL Survivors. In addition, exercise training improves physical capacity and heart rate responses in this set of patients.

Eligibility Criteria:
Inclusion Criteria:

* Hodgkin Lymphoma Survivors
* Over 18 years old
* Chemotherapy with anthracycline and mediastinal radiotherapy in the last 5 years or more

Exclusion Criteria:

* Renal insufficiency
* Pregnant women,
* Iodinated contrast allergy,
* Life expectancy less than 1 year.
Effectiveness of Respiratory Muscle Training by Spirotiger in Chronic Patients

The reduction in effort tolerance as result of a decreased efficiency in ventilation is common both in patients affected by COPD (McKenzie) and chronic heart failure (CHF) (Ribeiro, Frankenstein). One of the most common cause is the reduced respiratory muscle strength and endurance. Some studies have evaluated the effect of a specific training on the muscular strength both in pulmonary (Battaglia, Powell) and cardiac patients (Winkelmann, Chiappa). Moreover, only few studies investigated a specific training for such patients (Koppers, Sherer) because of the complicated equipment needed to prevent hypocapnia. Up to date, portable and economic systems for isocapnic hyperpnea have been developed for respiratory muscle training.

Primary aim of the study was to evaluate the effectiveness of the respiratory muscle training -by the technique of the isocapnic hyperpnea- on the effort tolerance and endurance in patients with COPD and CHF

Secondary aims were: A.to quantify the number of patients with deficit of respiratory muscles endurance and B.to verify different response of training between COPD and CHF patients

All consecutive stable patients with diagnosis of COPD or CHF and normal MMSE, admitted in Foundation S. Maugeri in Lumezzane (Brescia, Italy) for routinary rehabilitation at Respiratory and Cardiac Rehabilitative Divisions are enrolled.

All patients who met the inclusion criteria (see above)are informed about the aim of the project, sign an informed consent and are enrolled in the study.

40 patients are enrolled. They are divided in two groups of 20 each (10 cardiac and 10 respiratory patients) named:

1. Spirotiger Group: these patients perform 20 sessions of usual training (cyclette and calisthenic exercises) and specific training (further 20 sessions) for respiratory muscles with SPIROTIGER
2. Control Group: these patients perform 20 sessions of usual training (cyclette and calisthenic exercises) and additional 20 sessions with a placebo device (Threshold)

Eligibility Criteria:
Inclusion Criteria:

* Ability to perform 6-min walking test.
* Emogas analysis at rest (with PaO2\>60mmHg and PCO2\<45 mmHg)
* Mini Mental State Examination (MMSE) \> 25
* Absence of major events in the last month (i.e. respiratory exacerbation treated with antibiotic therapy, CHF unstabilization with administration of vasopressor drugs to support the cardiac pump).
* Maximum Voluntary Ventilation (MVV) as evaluation of endurance \<90%.

Exclusion Criteria:

* Haemodynamic instability
A Trial Comparing the Effect of Exercise on Blood Glucose in Subjects With Type 1 Diabetes, Who Are Treated With Either Insulin Degludec or Insulin Glargine

This trial is conducted in Europe. The aim of the trial is to compare the effect of exercise on blood glucose in subjects with type 1 diabetes, who are treated with either insulin degludec (IDeg) or insulin glargine (IGlar).


Eligibility Criteria:
Inclusion Criteria:

* Type 1 diabetes mellitus (as diagnosed clinically) for at least 12 months
* Body mass index 18.0-27.0 kg/m\^2 (both inclusive)
* Subjects performing regular physical cardiorespiratory activity
* Glycosylated haemoglobin (HbA1c) below or equal to 9.5 %

Exclusion Criteria:

* Subject who has donated any blood or plasma in the past month or more than 500 mL within 3 months prior to screening
* Smoker (defined as a subject who is smoking more than 5 cigarettes or the equivalent per day)
* Not able or willing to refrain from smoking and use of nicotine substitute products during the inpatient period
* Supine blood pressure at screening (after resting for at least 5 minutes) outside the range of 90-140 mmHg for systolic or 50-90 mmHg for diastolic
A Pilot Study at a Single-Institution of Pregabalin in the Management of Mucositis Pain in Patients Undergoing Chemoradiation Therapy to the Head and Neck.

To assess the efficacy of pregabalin in the management of mucositis pain in patients receiving radiotherapy to the head and neck. Eligible study subjects will be enrolled among those being treated for oropharyngeal cancer with definitive chemotherapy and radiation therapy (photons) to the head and neck in the Department of Radiation Oncology at the University of Pennsylvania.


Eligibility Criteria:
Inclusion Criteria:

* Patients being treated for oropharyngeal cancer with undergoing concurrent chemotherapy and radiation therapy (photons) for a histological diagnosis of squamous cell carcinoma to the head and neck at the University of Pennsylvania
* Age at least 18 years old
* Treatment entails significant risk for symptomatic mucositis likely to require opioid analgesia, as per the discretion of treating physician/NP
* Subjects are capable of giving informed consent

Exclusion Criteria:

* Patients anticipated to receive radiation therapy with Protons
* History of hypersensitivity to pregabalin or gabapentin
* History of seizure or currently taking anti-epileptic medication
* Creatinine clearance of less than 30 mL/min by Cockcroft-Gault estimate
* Has another painful condition requiring chronic use of opioid analgesic, gabapentin, or pregabalin
* History of serious mood disorder or attempted suicide as determined by patients history and physical and by using theDepression Screening
* Subjects with a score of greater than 10 or those answering #5 with scores greater than a "0" will be deemed ineligible to be enrolled on study
* History of angioedema
* New York Heart Association class III or IV heart failure
* Platelets of less than 150 mg/dL or history of thrombocytopenia
* The patient has any uncontrolled intercurrent illness including but not limited to psychiatric illness/social situations that would limit compliance or interfere with their ability to participate
Serum Biomarkers Associated With Postpartum T2DM in Women With GDM

Gestational diabetes mellitus (GDM) is commonly linked to the development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with GDM in order to find novel biomarkers for T2DM.

GDM, a common complication of pregnancy, affects 17.8% of pregnancies worldwide per year. Women with a history of GDM have an approximately 7-fold higher risk for developing T2DM in the future than women without GDM. However, data on the factors associated with the development of T2DM in women with GDM are not widely available.

Eligibility Criteria:
Inclusion Criteria:

* Women who were dignosed GDM.
* Women with singleton pregnancy.
* Give birth in the First Affiliated Hospital in Sun Yat-sen University.

Exclusion Criteria:

* Women who were diagnosed PGDM.
* Younger than 18 years old.
* Older than 45 years old.
* Multiple pregnancy.
* Diagnosed DM before.
* Complicationg other diseases, like hypertension, thyroid diseases, etc.
* Taking any drug affect glucose and lipid metabolism.
Early Increase in Blood Supply in Patients With Barrett's Esophagus

The purpose of this study is to determine if early Barrett's specialized intestinal metaplasia can be detected by measuring early increased blood supply of the esophageal tissue, with 4 Dimensional Elastic Light-Scattering Fingerprinting, (4D-ELF) technology in real time.


Eligibility Criteria:
Inclusion Criteria:

* age 18 years or older,
* informed written consent,
* patient scheduled for previously planned upper endoscopy

Exclusion Criteria:

* liver disease;
* gastric antral vascular ectasia (GAVE);any known non-esophageal aerodigestive malignancy;
* severe cardiopulmonary disease precluding endoscopy; presence of conditions not allowing biopsy (e.g. coagulation disorder);
* known familial polyposis syndrome (FAP, HNPCC, Juvenile polyposis, etc.);
* known pregnancy or sexually active females of childbearing age who are not practicing an accepted form of birth control.
Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock

The aim of the study was to investigate whether CVVH, in comparison to intermittent haemodialysis (IHD), is able to improve regional perfusion in septic shock patients studied by muscle microdialysis

A prospective, randomized, clinical study ,including septic shock patients with acute renal failure, aged over 16 years. Patients were randomized to receive either CVVH or IHD for renal replacement therapy. Intermittent haemodialysis was carried out during the first 4 h at day 1 and day 2 of the study period. Systemic haemodynamics and interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12,18 and 24 hours after initiation of renal replacement by using muscle microdialysis.

Eligibility Criteria:
Inclusion Criteria:

* septic shock

Exclusion Criteria:

-
The Effects of Valsalva Maneuver on Head, Neck and Upper Extremity Arterial Systems

The aim of this study is to determine the relation between arterial diameter and flow of carotis interna, brachial artery and radial artery before and after valsalva maneuver.

The aim of this study is to determine the relation between arterial diameter and flow of carotis interna, brachial artery and radial artery before and after valsalva maneuver. A total of 70 patients in preoperative period will enroll in this study. After a deep inspiration, patients will asked to exhale to a valf system with a flow pressure of 20-40 mmHg and duration of 15 seconds. During valsalva maneuver, the diameter and flow rates of carotis interna, brachial artery and radial artery will measure using ultrasound. All data will be recorded.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists score of I, II, III

Exclusion Criteria:

* Morbid obesity (body mass index over 40)
* Not to participate in the study
* Psychiatric diseases
* Peripheral vascular diseases
Integrating the Genetic and Metabolic Faces of Obesity

The goal of this study is to determine why some obese individuals develop insulin resistance and others do not. We hypothesize that an impairment in differentiation of fat cells (adipocytes) is responsible for the development of insulin resistance in select obese individuals. This study will evaluate obese individuals at baseline with respect to characteristics of adipocytes, including gene expression, and will then entail randomizing subjects to either weight loss or treatment with an insulin sensitizing drug (pioglitazone). Changes in insulin resistance will be associated with changes in adipocyte morphology and gene expression.

Healthy overweight/obese individuals will be screened for insulin resistance. Both insulin resistant individuals and insulin sensitive individuals (to serve as controls) will be eligible to enroll. Fat cel biopsy and CT scan of the abdomen is required at baseline and after an intervention with either weight loss or pioglitazone (drug to improve insulin resistance). Subjects will repeat insulin resistance test after the intervention as well. Subjects will learn much about their metabolism in this study, and will have an opportunity to improve their insulin resistance.

Eligibility Criteria:
Inclusion Criteria:

* nondiabetic defined as fasting plasma glucose \< 126 mg/dL
* body mass index 27 to 35 kg/m2
* no major organ diseases
* able to come to Stanford for regular clinical research center visits
* English speaking or has own translator

Exclusion Criteria:

* pregnancy/lactation
* history of eating disorder or major psychiatric illness
* allergy to thiazolidinedione
* elevation of liver enzymes (\> 2.5 times upper normal limit)