cyrilzakka/clinical-trials huggingface dataset:
Artificial Intelligence Algorithms for Discriminating Between COVID-19 and Influenza Pneumonitis Using Chest X-Rays

This project aims to use artificial intelligence (image discrimination) algorithms, specifically convolutional neural networks (CNNs) for scanning chest radiographs in the emergency department (triage) in patients with suspected respiratory symptoms (fever, cough, myalgia) of coronavirus infection COVID 19. The objective is to create and validate a software solution that discriminates on the basis of the chest x-ray between Covid-19 pneumonitis and influenza

This project aims to use artificial intelligence (image discrimination) algorithms;

* specifically convolutional neural networks (CNNs) for scanning chest radiographs in the emergency department (triage) in patients with suspected respiratory symptoms (fever, cough, myalgia) of coronavirus infection COVID 19;
* the objective is to create and validate a software solution that discriminates on the basis of the chest x-ray between Covid-19 pneumonitis and influenza;
* this software will be trained by introducing X-Rays from patients with/without COVID-19 pneumonitis and/or flu pneumonitis;
* the same AI algorithm will run on future X-Ray scans for predicting possible COVID-19 pneumonitis

Eligibility Criteria:
Inclusion Criteria:

* flu-like symptoms: myalgia, cough, fever, sputum
* Chest X-Rays
* COVID-19 biological tests

Exclusion Criteria:

* patient refusal
* uncertain radiographs
* uncertain tests results
The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar in young and elderly adults. This study involves direct vaccination of human volunteers. The endpoints will be determining how vaccination affects neutrophil responses and linking those neutrophil responses to antibody responses following vaccination. The main results will be:

1. Elucidating how neutrophils kill bacteria before and after vaccination
2. Elucidate the phenotype of neutrophils before and after vaccination
3. Elucidate how neutrophils interact with B and T cell in vitro before and after vaccination
4. Measure antibody levels and function before and after vaccination
5. Correlate neutrophil responses to antibody levels and function

Eligibility Criteria:
Inclusion Criteria:

* Both sexes
* Have not been vaccinated with any licensed or experimental pneumococcal vaccine
* Ages 21-40; and ≥65. Individuals \>60 years old will also be recruited in case we find no unvaccinated people ≥65 years old
* Free of acute infections within the last 2 weeks
* Did not take any anti-inflammatory medicine in the last week
* Did not ingest alcohol in the last 24 hours
* Ability and willingness to provide consent

Exclusion Criteria:

* Previous vaccination with any licensed or experimental pneumococcal vaccine
* Known hypersensitivity to vaccination and vaccine components
* Immune deficiency
* Use of immune-modulating or suppressive drugs
* Malignancies within the last 2 years
* Known hematological, rheumatic and inflammatory diseases
* Known chronic infections
* Poorly controlled chronic cardiovascular and metabolic conditions
* Pregnancy
* Dementia
OXXYNEA® GS: Study for Glycaemia Management

The aim of this study is to develop a proof of concept establishing a causal relationship between glycemia improvement through combination of polyphenols-rich botanical extracts or polyphenols-rich botanical extracts associated with white kidney bean extract and chromimum picolinate + zinc bisglycinate with chronic supplementation. Chronic glycemia improvement will be assessed by following the evolution of HbA1c, postprandial glucose and insulin kinetics, and questionnaires. The study design is double blinded randomized with 3 arms and 29 volunteers per arm.


Eligibility Criteria:
Inclusion Criteria:

* Fasting Plasma Glucose 75 - 125 mg/dL
* HbA1c: 5.-6.5 %
* Both sexes
* Overweight BMI range (25-30 Kg/m2)
* Age: 20-50 years old

Exclusion Criteria:

* Metabolic/Chronical disease
* Menopausal women
* Being pregnant, breastfeeding or wanting to have a baby
* Former obese with a history of yoyo effect
* Have been involved in a weight loss program in the past 12 months or subjected to weight reduction surgery
* Having started or quit smoking, having a high alcohol consumption
* Have in the past been in a long-term antibiotherapy (1 month or more) and/or a regular antibiotherapy in the past 12 months
* Allergy to olive, blackcurrant, pomegranate, grapefruit, white kidney bean, or corn.
Application of Multimodal Endoscopic Functional Imaging Technology in the Diagnosis of Common Gastrointestinal Diseases

We plan the study to explore the application of endoscopic laser speckle imaging and multispectral blood oxygen imaging to observe gastrointestinal lesions, as well as the differences in the morphology, density and functional status of mucosal surfaces and deep blood vessels of different gastrointestinal lesions, also to explore the role of endoscopic multimodal functional imaging in common gastrointestinal diseases, especially in the early diagnosis of gastrointestinal tumors.

The current focus of electronic endoscopy is on the morphology and fine structure of the mucosal surface, and there is no effective observation method for the deep structure of the mucosa and the function of blood oxygen binding. However, the multilayer morphology and functions of mucosal vessels under different conditions of digestive tract lesions should be different. Therefore, we propose a method of endoscopic multimodal functional imaging to the conventional endoscopic examinations observing the mucosa of the digestive tract, which is based on the existing electronic endoscope, laser speckle contrast imaging and multispectral blood oxygen imaging technology. Laser irradiation was given to obtain the information of coherent light on the mucosal surface and deep scattering of coherent light to obtain multi-level vascular distribution information, and multispectral irradiation imaging was carried out to obtain the oxygenation situation of the mucosa. Finally, we may find the differences of images of deep blood vessels among common gastrointestinal diseases, which could help us to make early diagnosis of gastrointestinal tumors noninvasively.

Eligibility Criteria:
Inclusion Criteria:

1. Age: 18-80 years old, gender is not limited
2. Diagnosed or suspected of one of the following common gastrointestinal mucosal diseases: Chronic non-atrophic gastritis, chronic atrophic gastritis, gastric polyps, early gastric cancer, advanced gastric cancer, colon polyps, colon melanosis, inflammatory bowel disease, early colon cancer, advanced colon cancer
3. Sign the informed consent form -

Exclusion Criteria:

1. Combined with cardiovascular and cerebrovascular diseases, or severe impairment of liver, kidney and hematopoietic system;
2. mentally ill;
3. the presence of bleeding disorders;
4. Platelet count\<50×10\^9/L;
5. Inability to tolerate or cooperate with endoscopy;
6. Patients with serious complications, such as severe infection, gastrointestinal bleeding, obstruction, perforation, etc.;
7. Pregnant or lactating women.
8. Refuse to sign the informed consent form
Safety, Tolerability and Relative Bioavailability of Pegvisomant in Healthy Subjects

The hypothesis to be tested is that the bioavailability of the new 30-mg vial is similar to that of the current approved 15 -mg vials. In addition, the SC injection using the new 30-mg vial is safe and well-tolerated.


Eligibility Criteria:
Inclusion Criteria:

* Healthy males or females between the ages of 21 and 55 years

Exclusion Criteria:

* Positive urine drug screen
* Excessive use of alcohol or nicotine-containing products
* Pregnant or nursing females
Prostaglandins Use Before Mirena IUD Insertion in Prev CS Women During Lactational Amenorrhea

This is a prospective randomized controlled study to determine the effect of prostaglandin intake before Mirena IUD insertion It was conducted at the Department of Obstetrics \& Gynecology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University,

The study aiming to measure the estimate difficulty of insertion of the Mirena IUD by using prostaglandins 2 hours before the procedure and the effect of prostaglandins to make this procedure easy with other side effects and complications as bleeding perforation, nausea, vomiting, failure of insertion and comparing them with a placebo group who didn't receive prostaglandins

Eligibility Criteria:
Inclusion Criteria:

* 1- Women in lactational amenoeehea with pregnancy test negative 2- Women who had caesarean section within 6 monthes of IUD insertion 3- No medical disorders

Exclusion Criteria:

* 1- Women in regular menses 2- Medical disorders 3- Nulligravida or muligravida with NVD 4- Women with history of Previous CS more than one CS 5- Any congenital uterine anomalies, fibroids and adenomysis 6- Chronic pelvic pain 7- Intrauterine adhesions 8- Spasmodic dysmenohrrea 9- Allergy to misoprostol
Reducing Cesarean Delivery Rate in Obese Patients Using the Peanut Ball

This study aims to determine if using the peanut ball during labor reduces the cesarean delivery rate when compared to normal intrapartum management (no peanut ball) in the obese patient population.

Currently at Geisinger Medical Center Danville, use of the peanut ball is at the discretion of attending or resident physicians, or obstetric nurses on the Labor and delivery team for the day. Despite the common use of this labor adjuvant tool, a well-designed prospective study is necessary to investigate if the peanut ball provides any benefit during the labor process for the obese gravida. If this simple tool is shown to reduce the rate of cesarean delivery, then hospital protocols could be changed to ensure its use during labor. This has the potential to decrease the rate of cesarean delivery in the most vulnerable patient population. The investigators propose a randomized controlled trial (RCT) to determine if using the peanut ball during labor provides a reduction in the cesarean delivery rate in the obese patient population. The investigators will compare cesarean delivery rates in patients using the peanut ball to patients receiving routine intrapartum management without the use of the peanut ball. Singleton pregnancies complicated by obesity, defined by pre-pregnancy BMI \> 30kg/m2, will be included.

Study participants will be randomized to one of the two study arms. The peanut ball arm (also referred to as study arm 1) will be managed according to the parameters specified for use of the peanut ball. The participants in the Control arm (also referred to as study arm 2) will be managed according to the standard intrapartum management as defined by Geisinger's Labor \& Delivery protocol and per the OB providers. The objective of the study is to determine if use of the peanut ball during labor reduces the cesarean delivery rate in the obese patient population. Secondary outcomes of interest include rate of cervical dilation, rate of operative deliveries, fetal position (occiput anterior vs. occiput posterior) at complete dilation (10 cm), and patient satisfaction.

Eligibility Criteria:
Inclusion Criteria:

* Admitted for delivery
* Pre-pregnancy BMI \> 30kg/m2
* Planned vaginal delivery at Geisinger Medical Center (GMC)
* Gestational age \> 37 weeks 0 days
* Singleton pregnancy
* Cephalic presentation
* English speaking

Exclusion Criteria:

* Pre-pregnancy BMI \< 30kg/m2
* Contraindication to vaginal delivery
* Planned cesarean delivery (i.e., an elective primary or repeat cesarean delivery)
* Gestational age \< 37 weeks 0 days
* Multifetal gestation
* Intrauterine fetal demise
* Non-English speaking
* Greater than 9cm at the time of randomization
Anti-calculus Efficacy of a Dentrifice Containing Sodium Pyrophosphate and Potassium Pyrophosphate in Heavy Calculus Formers

The purpose of this study was to determine the anti-calculus effect of dentrifice containing 5% sodium pyrophosphate and potassium pyrophosphate in a triple-mask placebo controlled randomized clinical trial.


Eligibility Criteria:
Inclusion Criteria:

1. Age group 15-30 years.
2. Subjects who have not received periodontal therapy within preceding 1year.
3. Heavy calculus formers with simplified calculus index score 1.5-3 .

Exclusion Criteria:

1. Age group 15-30 years.
2. Subjects who have not received periodontal therapy within preceding 1year.
3. Heavy calculus formers with simplified calculus index score 1.5-3 .
HZA113091 Efficacy and Safety of Fluticasone Furoate/Vilanterol (GW642444) in Adults and Adolescents

The purpose of the study is to compare the efficacy and safety of fluticasone furoate/vilanterol (GW642444) inhalation powder administered once daily with fluticasone propionate/salmeterol administered twice daily in adolescent and adult subjects 12 years of age and older with persistent bronchial asthma over a 24-week period.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of asthma
* Reversibility of at least 12% and at least 200mLs within 10-40 minutes following 2-4 inhalations of albuterol
* FEV1 of 40-85% predicted normal
* Currently using inhaled corticosteroid therapy

Exclusion Criteria:

* History of life-threatening asthma within previous 5 years (requiring intubation and/or was associated with hypercapnoea, respiratory arrest or hypoxic seizures)
* Respiratory infection or oral candidiasis
* Asthma exacerbation requiring oral corticosteroids or that resulted in overnight hospitalisation requiring additional asthma treatment
* Uncontrolled disease or clinical abnormality
* Allergies
* Taking another investigational medication or prohibited medication
* Night shift workers
* Current smokers or subjects with smoking history of at least 10 pack years
BUCYE Conditioning Regimen for PCNSL Undergoing Auto-HSCT

The purpose of this study is to evaluate the safety and efficacy of BUCYE conditioning regimens in primary central nervous system lymphoma undergoing autologous hematopoietic stem cell transplantation.

The prognosis of patients with primary central nervous system lymphoma (PCNSL) is poor. Recent studies have demonstrated that autologous hematopoietic stem cell transplantation (auto-HSCT) could improve the prognosis of these patients. However, the optimal conditioning regimen of auto-HSCT remains unclear. In this study, the investigators evaluated the safety and efficacy of BUCYE conditioning regimens in PCNSL undergoing auto-HSCT.

Eligibility Criteria:
Inclusion Criteria:

* Primary central nervous system lymphoma patients
* Achieving CR or PR, then mobilizing and collecting of peripheral blood stem cells

Exclusion Criteria:

* Any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure)
* Patients with any conditions not suitable for the trial (investigators' decision)
Effect of Caldine® on Renal Function in Balanced Hypertension

The study aimed at comparing the evolution of renal function in patients showing a hypertension treated by various therapeutic strategies.

Due to the contract research organisation (CRO) decision in September 2000, the database was locked and not accessible for Boehringer Ingelheim France. Consequently it was decided to stop the study and not proceed to the analysis. Thus, only safety data were processed in the safety database.


Eligibility Criteria:
Inclusion Criteria:

* patients with hypertension requiring treatment

Exclusion Criteria:

* none
Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic Purpura

The study was a Phase III, double-blind, placebo-controlled, randomized study to evaluate the efficacy of caplacizumab in more rapidly restoring normal platelet counts as measure of prevention of further microvascular thrombosis


Eligibility Criteria:
Inclusion Criteria:

1. Adult male or female ≥ 18 years of age at the time of signing the informed consent form (ICF).
2. Clinical diagnosis of acquired thrombotic thrombocytopenic purpura (aTTP) (initial or recurrent), which included thrombocytopenia and microscopic evidence of red blood cell fragmentation (e.g., schistocytes).
3. Required initiation of daily PE treatment and had received 1 PE treatment prior to randomization
4. Others as defined in the protocol

Exclusion Criteria:

1. Platelet count ≥100×10E9/L.
2. Serum creatinine level \>200 µmol/L in case platelet count is \> 30×10E9/L
3. Known other causes of thrombocytopenia
4. Congenital TTP (known at the time of study entry).
5. Pregnancy or breast-feeding.
6. Subjects who were previously enrolled in a clinical study with caplacizumab and received caplacizumab or for whom the assigned treatment arm is unknown
7. Others as defined in the protocol
Effectiveness of Upper Quarter Biodex Training

Strength, and proprioception training of upper body following injuries is commonly recommended. However, there are no previous studies investigated the effects of Biodex balance training on the strength, stability and function of the upper quarter. So, the purpose of this study will investigate the effect of Biodex balance training on improving the strength, dynamic stability and function of the upper quarter in young recreational weightlifters.

Study design This is randomized controlled study. There are two groups classified randomly (group A \& group B); group (A); will receive upper extremities biodex balance training. 3 times/week for 8 weeks and group B that receive no treatment just assessment pre and post. Both groups will receive their regular weightlifting training exercises 4times/week.

Procedures Testing procedures Data collection from the testing procedures in the pre and post interventional phase will take place over two days to avoid the impact of fatigue on the participants' physical performance. In the first day, descriptive data will be measured and recorded for each subject including age, height, weight, upper extremity dominance (defined as the hand reported to be preferred for ball throwing). This will be followed by the upper quarter Y- balance (UQ-YBT) and the Dynamic limits of stability (DLOS) using the Biodex balance system. In the second day, data will be collected from the 2-minutes 90° push-up test and the one-arm hop test. The order of days and testing procedures will be randomized for all participants.

Training procedure Total number of 24 training sessions will be scheduled to the participants in group A over a period of eight weeks (three sessions/week). The Rating of perceived exertion (RPE) or Modified Borg scale (MBS) was used to monitor and guide exercise intensity. The scale allowed participants to subjectively rate their level of exertion during training. It starts at number 0 where training is causing no breathing difficulty at all and progress through to number 10 where breathing difficulty is maximal. Training will start with the current level of balance of each participant at which he reports exertion level of ≥ 5 based on modified Borg scale and progressed towards the more difficult ones. The Biodex display screen will be connected to a computer screen that will be positioned at a level to allow visual feedback to the participants during training The transition from one level to the more difficult one will be based on composite score of \> 95% at the present level. Each training session will consist of three minutes training and one-minute rest, repeated for a total of 20 minutes.

Eligibility Criteria:
Inclusion Criteria:

* Healthy recreational male weightlifters aged between 19 and 25 years

Exclusion Criteria:

* if they took any hormonal supplements, participated in professional bodybuilding or power lifting competition, had shoulder pain or history of surgery or musculoskeletal injuries and if they dropped out their gym workout for more than three weeks in the last six months.
Comparable Study of Different Radiation Dose in Esophageal Carcinoma

Radiation therapy plus concurrent chemotherapy is now the standard therapy for patients with localized carcinoma of the esophagus selected for nonsurgical treatment. The standard radiation dose is 50-50.4Gy/1.8-2.0Gy/F.All of this were based on 2D radiation technology. Entering new century, 3D-CRT or IMRT has used on esophageal cancer. In China,the recommend radiation dose of concurrent chemoradiation was 60Gy. The study is a clinical phase III, randomized trial to compare the different radiation dose(60Gy vs 50Gy) of concurrent chemoradiation using 3D-CRT or IMRT in patients with unresectable esophageal carcinoma.


Eligibility Criteria:
Inclusion Criteria:

* Histological or cytologic diagnosis of esophageal carcinoma
* ECOG performance status 0-1
* Age:18-70 years
* Joined the study voluntarily and signed informed consent form
* Patients must not have received any prior anticancer therapy
* Unresectable disease, or refuse surgery.Stage Ⅰ-ⅣA（AJCC 2009）
* Target lesions can be measured according to RECIST criteria
* No serious system dysfunction and immuno-deficiency, Adequate organ function including the following: Hemoglobin ≥9 g/dL, WBC≥3x109/L, Neutrophils (ANC )≥1.5x109/L, platelet count ≥100x 109/L, TBIL\<1.5 x ULN, ALT and AST ≦ 2.5 x ULN, creatinine ≦ 1.5 x ULN
* Use of an effective contraceptive for adults to prevent pregnancy
* Life expectancy of more than 3 months

Exclusion Criteria:

* Multiple carcinomas of the esophagus,
* Biopsy-proven invasion of the tracheobronchial tree or tracheoesophageal fistula,
* Metastatic disease (M1),
* A primary tumor that extended to within 2 cm of the gastroesophageal junction,
* Prior chemotherapy, prior thoracic radiation, surgical resection of the primary tumor,
* Concurrent pregnancy or lactation, history of a second malignancy other than nonmelanoma skin cancer
A Study of Chidamide With AZA in MRD Positive AML After Transplant

acute myeloid leukemia (AML) is a malignant tumor of the hematopoietic system with high heterogeneity in cytogenetics and molecular biology.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still the primary treatment option for patients with AML and the most effective method for radical treatment of AML.Despite considerable progress in allo-HSCT over the past decade, 30%-40% of patients still relapse, and post-transplant relapse remains the leading cause of death in patients with AML.

Investigators proposed Chidamide combined with azacitidine as the prospective treatment for MRD-positive AML patients before and after transplantation, hoping to reduce the recurrence rate of transplantation and improve the transplantation effect. The efficacy and safety of the method will be verified by this clinical study.

Eligibility Criteria:
Inclusion Criteria:

1. Patients diagnosed with AML (diagnostic criteria refer to WHO2016 criteria, except M3) can detect small residual lesions (MRD) positive after allogeneic hematopoietic stem cell transplantation (allo-HSCT);
2. ≥18 years old;
3. ECOG≤3;
4. lifespan≥3 months;
5. Take contraceptive measures;
6. Sign informed consent.

Exclusion Criteria:

1. Allergic to the study drug;
2. A gastrointestinal condition that prevents oral medication;
3. active infection;
4. Dysfunction of vital organs;
5. other malignancies;
6. HIV infection;
7. HBV or HCV;
8. The QT interval is prolonged;
9. Pregnant or lactating women;
10. Is participating in other clinical studies;
11. The researchers did not consider it appropriate to participate in this study.