cyrilzakka/clinical-trials huggingface dataset:
Outcomes of Critically Ill Patients With Severe Acute Kidney Injury Requiring Renal Replacement Therapy

This study assess the vital status, renal function and renal recovery of patients admitted to intensive care unit and requiring renal replacement therapy for acute kidney failure. Patient follow up is up to 3 years after ICU admission when possible.

Up to 50% of critically ill patients develop acute kidney injury and up to 10% require renal replacement therapy in the intensive care unit. This study aims to identify factors associated with mortality and to evaluate renal recovery of patients who had acute kidney failure requiring renal replacement therapy in intensive care unit at 1 and 3 years post intensive care unit admission.

Eligibility Criteria:
Inclusion Criteria:

* Adults admitted to the intensive care
* Acute kidney failure requiring renal replacement therapy

Exclusion Criteria:

* Patients suffering end stage renal failure requiring chronic renal replacement therapy
* Patients under 18 years
Noninvasive Ventilation After Extubation in Hypercapnic Patients

The purpose of this study is to assess the efficacy of noninvasive ventilation (NIV) in the prevention of extubation failure and mortality in patients with either chronic respiratory disorders or hypercapnic respiratory failure during spontaneous breathing.

Reintubation, which occurs in 6 to 23% within 48 to 72 hours after planned extubation, is a relevant consequence of respiratory failure after extubation. Patients with chronic respiratory disorders and invasively mechanically ventilated in intensive care unit, often exhibit hypercapnia, during breathing trial prior extubation. This is associated to increased incidence of extubation failure and mortality. Although the need for reintubation may be a marker of increased severity of illness, this is an independent risk factor for nosocomial pneumonia, increased hospital stay and mortality. NIV does not seem to be beneficial in avoiding reintubation when these patients have developed respiratory failure. However, a recent randomised study demonstrated that the early use of NIV averted respiratory failure after extubation in patients at increased risk. The patients were considered at risk if they had at least one of the following criteria: age \> 65 years, cardiac failure, increased severity assessed by an Acute Physiologic and Chronic Health Evaluation score \> 12. But, the beneficial effects of NIV on survival appear to be restricted to patients with chronic respiratory disorders and hypercapnia during the spontaneous breathing trial. So the beneficial effects of NIV should be confirmed in a trial in this specific population. We planned to conduct a study evaluating the efficacy of NIV in the prevention of extubation failure and mortality in these patients. If no signs of respiratory failure appeared after 120 min of a spontaneous breathing trial, patients will be extubated and randomly allocated after extubation to NIV group or control group. The clinical follow-up will be as follow: the incidence of extubation failure, the reintubation, the ICU and hospital mortality, 28-day survival, the complications associated to mechanical ventilation, ICU and hospital length of stay.

Eligibility Criteria:
Inclusion Criteria:

* Patients intubated for 48 hours or more
* Patients with Chronic respiratory disorders
* And/or hypercapnic respiratory failure during successful spontaneous breathing trial

Exclusion Criteria:

* Face or cranial trauma or surgery
* Home noninvasive ventilation
* Recent gastric or oesophageal surgery
* Tracheostomy or other upper airway disorders
* Upper gastrointestinal bleeding
* Excess respiratory secretions
* Lack of collaboration
* Do not resuscitate order or any decision to limit therapeutic effort in the ICU.
Treatment of Renal Colic in the Emergency Department: Comparison Between Magnesium Sulfate and Lidocaine.

Rate of Intravenous Magnesium Sulfate Vs Lidocaine to treat Renal Colic in the Emergency Department.

Magnesium Sulfate (MgSO4) is a N-Methyl-D-aspartate (NMDA) receptor antagonist and is thought to be involved in the modulation of pain. There has been little direct evidence that MgSO4 relieve neuropathic pain and prevents opioid-induced hyperalgesia in humans.

Intramuscular Diclofenac seems to offer the most effective sustained analgesia for renal colic in the ED and has few side effects.

Lidocain became the agent of choice in visceral and central pain. Intravenous Lidocain is effective in the management of neuropathic pain such as diabetic neuropathy, post-surgical pain, post-herpetic pain, headaches and neurological malignancies. At low doses, Lidocain is known as a relatively safe medication. Lidocain seems an effective treatment who can be administrated in the renal colic.

Objective of study:

Evaluate the analgesic effect of a standard dose of intravenous magnesium added to intramuscular diclofenac compared to intravenous Lidocain combined to intramuscular diclofenac or intramuscular diclofenac alone in patients presenting to the ED with renal colic and whether it can reduce opioid consumption.

Eligibility Criteria:
Inclusion Criteria:

* Informed consent.
* Age between 18 and 65 years .
* Diagnosis of renal colic made by an emergency medicine physician, based on history and clinical findings, and urine analysis or by identifying the urinary tract stone using ultrasonography or radiologic imaging including CT scan .-With moderate to severe pain (visual analogic Scale ≥5 ).

Exclusion Criteria:

* known renal or hepatic dysfunction, use of NSAIDs and/or opioids within 6 h before presentation
* history of bleeding diathesis, history of peptic ulcer disease or gastrointestinal hemorrhage,
* History of cardiac arrhythmia, severe coronary artery disease, seizures, presence of any peritoneal sign, altered mental status, and anticoagulant medication or coagulation disorders.
* Use of any analgesics or spasmolytics in the previous 4 hours before admission, hemodynamic instability, and prior known allergy to lidocaine or morphine .
* Pregnant women , Breast feeding
* Allergy or contraindications to NSAIDs, lidocaine or MgSO 4
The Predictors and Benefits of Multi-discipline Disease Management Program in Heart Failure Patients

The investigator will investigate the predictors includes cardiac biomarkers, endothelial function and cardiopulmonary exercise test in prediction of cardiovascular outcome in patients with heart failure discharged from hospital.

Background: Readmission and mortality are high after heart failure (HF) hospitalization. Heart Failure Multi-discipline disease management program (HFDMP) has shown to decrease 30% in readmission for decompensated heart failure or other cardiovascular causes. This was associated with a decreased in medical cost of care and a trend towards a lower mortality rate. Despite evidence that HFDMPs is effective, however, they are not widely employed in Taiwan. Some HFDMPs did not show improved health status compared with usual care. The "best way" to design and implement a HFDMP is not clear. It is still not clear if HFDMP would benefit all heart failure patients or should instead be targeted to specific subsets. Lysyl oxidase-like 2 (Loxl2) is enzyme, which crosslinks collagen in fibrotic processes such like liver cirrhosis or lung fibrosis. Recently, Lysyl oxidase-like 2 (Loxl2) was also found to participate the process of cardiac interstitial fibrosis and heart failure. Interestingly, the serum level of Loxl2 is in good correlation with the severity of heart failure. However, there is still unknown whether Loxl2 is useful biomarker for predicting the long-term outcome in patient with heart failure. From the mechanism of Loxl2 in the process of heart failure, the serum level of Loxl2 may be a good maker for predict the degree of cardiac remodeling. Our animal study showed the correlation between myocardial fibrosis and Loxl2 serum level. Therefore, The investigator will investigate whether serum Loxl2 level is a good maker for predictor the long-term outcome in patient with heart failure and predictor of cardiac remodeling. The correlation between this novel cardiac biomarker and endothelial function, cardiopulmonary function test will also be evaluated.

Objectives: The investigator will investigate the predictors includes cardiac biomarkers ( such as serum Loxl2 level, B-type natriuretic peptide (BNP), soluble ST2), endothelial function and cardiopulmonary exercise test in prediction of cardiovascular outcome and reverse remodeling in patients with heart failure discharged from hospital.

Design: A prospective cohort study

Eligibility Criteria:
Inclusion Criteria:

1. Patients must give written informed consent before any assessment is performed.
2. Inpatients ≥ 18 years of age, male or female.
3. Patients with a diagnosis of heart failure New York Heart Association (NYHA) class II-IV with BNP \>100 pg/mL

Exclusion Criteria:

1. Estimated survival time \< 6 months
2. Long-term bedridden more than 3 months
3. Cannot tolerance exercise test due to muscular skeletal disorder
4. Cannot co-operate all functional studies
5. Ventilator dependent
6. Terminal heart status
7. Family reject to participate this project
Study of a Simplified Geriatric Evaluation Performed by Oncologists Prior to Cancer Treatment by Radiotherapy or Chemotherapy in Subjects Aged 70 Years or Older With Inoperable Squamous Cell Cancer of the Head and Neck

Use by Oncologists of Validated Geriatric Assessment Tools: G8 Screening Test and Certain Tests for Thorough Geriatric Evaluation


Eligibility Criteria:
Inclusion Criteria:

* Subject aged 70 or over
* Carrier of squamous cell carcinoma of the head and neck, locally advanced undergoing treatment by radiotherapy or metastatic / recurrence not accessible to treatment curative locoregional under treatment with chemotherapy.
* Patient likely to be eligible for ELAN-RT or ELAN-FIT or ELAN-UNFIT trials.
* Patients affiliated to a social security scheme

Exclusion Criteria:

* Person deprived of liberty or under guardianship,
* Presence of a neuro-psychological condition, family, social, or geographical, which may hinder the smooth running of the study.
* Patient expressing opposition to participation in this study
Effect of Insoles in Patients With Systemic Lupus Erythematosus

Demonstrate that custom-made insoles improve painful symptomatology, health and foot function in subjects with SLE and podiatric involvement.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or more.
* Medical diagnosis of LES.
* Foot involvement.

Exclusion Criteria:

* Treatment with foot orthoses.
* LES with acute symptomatic flare.
* Ulcers.
* Skin involvement.
* Neurological problems.
* Cognitive deterioration.
* Need for walking assistance.
* Refused to change footwear to use the foot orthoses.
Comparison of Two Electroencephalogram (EEG)-Derived Indices With Electroencephalogram Signals

Bispectral Index (BIS) and Entropy indices will be compared with each other, and to raw EEG signals in patients receiving sevoflurane anaesthesia. BIS and Entropy numbers often differ significantly from each other during surgery, and the reason for this has not been studied in detail, therefore remaining only poorly understood. BIS and Entropy, together with multi-channel EEG, will be collected and analyzed later on. Course of anaesthesia and surgery will be annotated. All relevant information from anaesthesia monitor will be collected on computer.


Eligibility Criteria:
Inclusion Criteria:

* Planned surgery necessitating general anaesthesia
* Expected duration of anaesthesia 30 min or more
* Need of endotracheal intubation
* ASA status 1, 2 or 3

Exclusion Criteria:

* Significant disorders of the autonomic or central nervous system
* Family history of malignant hyperthermia
* Clinical history of anaphylactic reaction against inhaled anaesthetics
* Disability to communicate with Finnish language
Mechanical Ventilation-Associated Complications and Co-Morbidities in Children Admitted in Pediatric Intensive Care Unit

The goal of this study was to identify the prevalence of mechanical ventilation-associated complications and co-morbidities in pediatric patients admitted to the PICU of Benha University Hospital, uncover how often these problems occur, their types, factors linked to them and to compare the epidemiology of MV-associated complications.

Mechanical ventilation (MV) is used frequently for critically ill children in pediatric intensive care unit (PICU). While respiratory disease is a major indication for invasive mechanical ventilation (IMV), there are also numerous non-respiratory indications for mechanical ventilation, including neurological and neuromuscular pathology, congenital heart disease, hemodynamic shock, and postoperative care and pain management and septic shock.

Although lung-protective ventilation strategies are extensively implemented in the pediatric population, frequent adverse events (AEs) of mechanical ventilation are detected, such as accidental extubation, atelectasis, trauma by aspiration, ventilator-associated pneumonia (VAP), perioral tissue damage, secretion-mediated obstruction of the endotracheal tube (ETT), mucus plugging, air leak syndromes, neuromyopathy, post-extubation stridor, and PICU delirium. Some of these events require the direct intervention of the physician, nurse, or physiotherapist in order to be identified; thus, they are associated with the quality of care.The incidence of these complications among pediatric patients in the PICU is noteworthy, with rates ranging from 27 to 97 adverse events per thousand patients per day. This is mainly associated with hazardous invasive procedures that can lead to unfortunate poor outcome.Few studies focus on the complications of using ventilators in infants and adolescents, especially regarding VAP cases.

The goal of this study was to identify the prevalence of mechanical ventilation-associated complications and co-morbidities in pediatric patients admitted to the PICU of Benha University Hospital, uncover how often these problems occur, their types, factors linked to them and to compare the epidemiology of MV-associated complications.

Eligibility Criteria:
Inclusion Criteria:

* all pediatric patients aged 29 days to 16 years who were admitted to the pediatric intensive care unit and underwent invasive mechanical ventilation for at least 24 hours between January 2021 and December 2023.

Exclusion Criteria:

* newborns (\<29 days old),
* pediatric patients received invasive mechanical ventilation less than 24 hours
* children with chronic respiratory failure or unable to be discharged due to socioeconomic constraints and requiring long-term mechanical ventilation therapy and pediatric patients with incomplete data or transferred to another hospital.
Measurement of the Radiation Dose Cuticles Using Electron Paramagnetic Resonance (EPR)

This study is to test the effectiveness a new method (called EPR dosimetry) that could be used to measure radiation doses to fingernails that occur as a result of unplanned exposure to radiation, such as might occur from the actions of terrorists, or from accidents.

In the event of a radiological exposure incident, such as the detonation of a radiological dispersion device (RDD) in a terrorist attack or accidental exposures to sources of ionizing radiation, it is advantageous to use multiple methods to assess the dosimetry of individuals exposed to this radiation (4). These methods should include a physical assessment of the dosimetry at the exposure site to, 1) identify the type of radiation (e.g., gamma rays, neutrons or radioisotopes), 2) evaluate the distribution of radioisotopes and/or radioactivity at the site, and 3) determine the location of exposed individuals to the source of radiation. For individuals affected by the radiological incident, the monitoring of their clinical signs and symptoms is important for determining whether acute symptoms of radiation sickness are being presented and if immediate medical intervention is required. However, it is recognized that an invaluable aid for the clinical management of exposed individuals is the use of biomarkers that can be readily obtained from the exposed individual and used for assessing dosimetry (4,9). Biomarkers that are most useful to the physician are those produced or expressed within minutes to hours following exposure. With the dosimetry provided through these early phase biomarker measurements, the physician can better assess the clinical signs that are presented by an exposed individual and better determine the need and course of treatment.

Eligibility Criteria:
Inclusion Criteria:

Arm 1:

* Radiation field to include one or more fingernail or toenail;
* KPS \> 70;
* For TBI subjects: sufficient cuticle length (3 mm or greater) on all fingers and/or toes.

Exclusion Criteria:

* Prior therapeutic radiation doses to the fingernails;
* Life expectancy \< 6 months;
* lifetime radiation dose of greater than 0.1 Gy through prior radiation therapy or occupational exposures.
TISSUE SHRINKAGE DEPENDS ON FORMOL SOLUTION IN DIFFERENT GASTRIC LOCATIONS

Generally % 10 formol solution is use to do fixation to all specimens after the surgical operations for the pathological evaluation. It is known that the formol solution cause amount of shrinkage in the tissue volume . This effect of formol solution had researched in colon,breast and prostate previously. But there is no evidence about stomach. The purpose of this research is that find out the formol effect to the gastric tissue and detect the shrinkage percent.

All gastric specimens which removed after Laparoscopic Sleeve Gastrectomy will open from the major curvature and spread down to the table.in operating room..3 cm x 3 cm three tissue samples will collect from the specific locations. These three locations are ; fundus( 1 cm from the top of staple line) , corpus (middle of the major curvature , antrum ( 1 cm far from the bottom of staple line ). All these points 5 mm far from the major curvature. 6 samples will prepare totally. 2 samples for each location ; one mucosa and one all layer of gastric wall for each location .These 3 points will examine about wall thickness(mucosa- submucosa-muscularis propria -serosa ) After saving the measurements in operating room;the gastric specimen will deliver to a pathologist to put the specimen into the % 10 formol solution. After 24 hours ;pathologist will save all of new measurements same in operating room. The measurements of sample are ;height , length , width . After the completion of the measurements the investigator will compare the results found in operating room in fresh specimen with pathologist 's results after formol. After that the investigator will be able to decide the shrinkage of gastric tissue in % 10 formol solution.

Eligibility Criteria:
Inclusion Criteria:

* Patients older than 18 years old who will undergo to Laparoscopic Sleeve Gastrectomy

Exclusion Criteria:

* Patients who has to undergo another bariatric surgery type peroperatively
* Deformation of gastric specimen while removing from the abdomen
Exploring the Effects of Aerobic Exercise Combined with BFRT on Patients with COPD

Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in COPD patients.

The systemic effects of Chronic Obstructive Pulmonary Disease (COPD) can precipitate a series of complications, including cardiovascular disorders, muscle atrophy, and osteoporosis. These comorbid conditions often result in decreased physical activity and suboptimal physical fitness, compelling patients to lead a sedentary lifestyle to mitigate exercise-induced dyspnea. Addressing the limitations in exercise tolerance remains a critical therapeutic goal in the treatment of COPD. According to research, exercise intolerance is caused by both poor pulmonary function and associated skeletal muscle dysfunction. Blood flow restriction training, a new rehabilitation technique, has shown promise in improving muscular strength at lower exercise intensities and in shorter timeframes, presenting a fresh approach to COPD rehabilitation.

The research aims to investigate the impact of incorporating blood flow restriction training into a holistic aerobic exercise program on exercise capacity and quality of life among patients with COPD. The findings are intended to clarify the potential of this innovative training technique as a supplementary therapeutic strategy in the management of COPD.

Eligibility Criteria:
Inclusion Criteria:

1. COPD classified as levels 2-4.
2. Stable condition without worsening in the past three months.
3. No participation in any rehabilitation program within the past six months.
4. Ability to understand and follow verbal commands and cooperate with an exercise training program.

Exclusion Criteria:

1. Unconscious or unable to cooperate with the evaluator.
2. Hospitalization due to acute illness within the past three months.
3. Severe joint diseases or history of lower limb surgery.
4. Severe cardiovascular disease (e.g., presence of a cardiac pacemaker or acute myocardial infarction within the past six months).
5. Dependence on oxygen supply.
The Brain Activation During Different Motor Patterns in Healthy Adults

This study aims to investigate the brain activation during different motor patterns, including motor execution (ME), motor imagery (MI), action observation (AO) and mirror visual feedback (MVF). In addition, the relations between brain activation and motor performance will also be explored. This study includes two parts, which are upper limb and lower limb part. While executing all the tasks, brain activation in primary motor cortex(M1), premotor cortex(PMC), and supplementary motor cortex(SMA) will be monitored by functional near-infrared spectroscopy. One-way ANOVA with repeated measure will be used to detect the differences of brain activation level between each mode. Pearson correlation coefficient will be used to determine the relations of brain activation and motor performance.

In upper limb part, subjects will be instructed to execute functional reaching task in ME, MI, AO, and MVF mode. During ME mode, motor performance including maximum speed, maximum acceleration, and jerk will be collected simultaneously. In the lower limb part, subjects will be instructed to walking over ground in ME, MI, and AO mode. During ME mode, the temporal and spatial gait parameters, including speed, stride time, cadence, and stride length will be collected.

Eligibility Criteria:
* Inclusion Criteria

  1. Age between 20 to 30 years.
  2. Right-handed.
  3. Ability to walk 30 meters independently without an assistive device.
  4. No neurogical, cardiopulmonary, or muscle diseases that might interfere with the experiment.
  5. Mini-Mental State Examination (MMSE) score greater than 24.
* Exclusion Criteria 1. Physiological condition is unstable.