cyrilzakka/clinical-trials huggingface dataset:
Measurement of Muscle Relaxation of the Hand in From Two Muscles and Two Hand Positions

Does movement of hand from supination to pronation affect the cut threshold for electomyography (EMG) relaxation measurement Does the threshold level differ between adductor pollucis and dorsal interosseus muscle


Eligibility Criteria:
Inclusion Criteria:

* age 18-65 years
* American society of anesthesiology (ASA) classification 1-2
* Elective surgery under general anesteshia with no planned need for muscle relaxation
* Body mass index \<35 kg/m3

Exclusion Criteria:

* Know central nervous system disease
* Know central nervous system impairment
* known medication affection peripheral nervous system
Evaluate the Neurological Effects of EryDex on Subjects With A-T

This is an international, multi-center, randomized, prospective, double-blind, placebo-controlled, Phase 3 study, designed to assess the effect of EryDex (dexamethasone sodium phosphate \[DSP\] in autologous erythrocytes), administered by intravenous (IV) infusion once every 28 days, on neurological symptoms of patients with Ataxia Telangiectasia (A-T).

The EryDex System (EDS) is a combination product that is used to load dexamethasone sodium phosphate (DSP) into autologous erythrocytes (EryDex) which is infused into the patient.

In the placebo arm, the subjects will receive autologous erythrocytes prepared with the EDS process using a placebo solution.

Upon completion of all screening assessments for eligibility, subjects meeting all selection criteria at baseline will be randomized in a 1:1 fashion to EryDex or placebo. Approximately 86 subjects 6- to 9-years-old, approximately 43 per group, will be randomized. Approximately 20 subjects 10 years of age and above, 10 per treatment group, may also be enrolled.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of A-T
* In autonomous gait or is helped by periodic use of a support
* Genetic confirmation of A-T
* Body weight ≥15 kg

Exclusion Criteria:

* Participation in another clinical study
* Immune impairment
* History of severe impairment of the immunological system
* Current neoplastic disease or previous neoplastic disease not in remission for at least 2 years
* Severe or unstable pulmonary disease
* Uncontrolled diabetes
* Current chronic or acute significant renal and/or hepatic impairment
* Any previous oral or parenteral steroid use within 6 weeks before Baseline. Treatment with inhaled or intranasal steroids for asthma or allergies, as well as use of topical steroids will be permitted
* A disability that may prevent the subject from completing all study requirements
Resolution of Liver Fat in Non-alcoholic Fatty Liver Disease

The major adverse health consequences of obesity occur only when non-alcoholic fatty liver disease (NAFLD) also develops. NAFLD is characterized by abnormal hepatic accumulation of triglycerides and other lipids. The first-line approach to NAFLD management is caloric restriction and weight loss, but these remain difficult to achieve. Little attention has been given to dietary carbohydrate restriction, despite recent reports showing that hepatic de novo lipogenesis, a process that converts dietary carbohydrates into fatty acids in the postprandial state, accounts for approximately 25% of liver triglyceride content in hyperinsulinemic subjects with NAFLD. For comparison, only 15% of the liver triglycerides were derived from dietary fatty acids in patients with NAFLD who had consumed a standardized 30% fat diet for four days before being assessed.

To establish the time-course of hepatic fat loss in NAFLD subjects on a carbohydrate-restricted diet (\<20 g/day), a serial assessments of liver fat during two week diet will be performed. Also, markers of lipid and insulin metabolism, liver function test and changes in gut microbiota during rapid metabolic improvement will be assessed.

The overall aim is to exploit this unique set of human material to determine the specific cellular and molecular pathways that are modified in the early stages of metabolic improvement and fatty liver regression.

Eligibility Criteria:
Inclusion Criteria:

* increased liver fat above 5 % in magnetic resonance spectroscopy
* body mass index 27-39.9 kg/m2

Exclusion Criteria:

* liver cirrhosis
* portal hypertension
* chronic liver disease other than NAFLD
* diabetes mellitus or other significant endocrine disease
* any medication acting on nuclear hormone receptors or inducing liver enzymes or self-administration of supplements other than calcium or vitamins/trace elements
* any significant cardiovascular co-morbidity
* history of non-compliance
* genotype (PNPLA3-MM and TM6SF2-TT) promoting liver fat accumulation
Drug Transporter Interaction Study PHENTRA_2015_KPUK

The objective of the present study is to contribute to establishing in vivo phenotyping procedures for organic anionic transporter polypeptide 1B1 (OATP1B1), organic cation transporters 1 and 2 (OCT1/2), multidrug and toxic compound extrusion transporters 1 and 2,kidney splice variant (MATE1/2K), organic anion transporters 1 and 3 (OAT1/3), and p-glycoprotein (P-gp) transporters via a cocktail approach. To this end, marker substrates for each of the respective transporters are administered as single doses in one period each and as a cocktail in one period to 24 healthy volunteers, and phenotyping metrics are derived from plasma and urine concentrations.

Blood sampling: - 0:15 h pre-dose, 0:15, 0:30, 0:45, 1:00, 1:20, 1:40, 2:00, 2:20, 2:40, 3:00, 3:30, 4:00, 5:00, 6:00, 8:00, 12:00, 16:00, 24:00 hours post-dose

Urine Sampling: Pre-dose, 0-4 hours, 4-8 hours, 8-12 hours, 12-16 hours, 16-24 hours

Drug analysis: by liquid chromatography - tandem mass spectrometry (LC-MS/MS)

Pharmacokinetic Characteristics: Evaluation is carried out using standard noncompartmental characteristics including: area under the plasma concentration vs. time curve truncated at time t (AUC0-t), area under the plasma concentration vs. time curve extrapolated to infinity (AUC0-∞), peak plasma concentration (Cmax), time of occurrence of Cmax (tmax), apparent elimination half-life (t½), clearance over bioavailability (CL/F), renal clearance (CLr) and renal secretion. The evaluation may be completed by compartmental population pharmacokinetic approaches.

Statistical evaluation: Pharmacokinetic characteristics are compared for cocktail administration vs. individual administration by standard average bioequivalence assessment.

Safety, tolerability: Adverse events, laboratory and clinical parameters and vital signs will be assessed.

Eligibility Criteria:
Inclusion Criteria:

* Caucasian
* Body mass index (BMI) between and inclusive 18.5 and 30 kg/m2
* Willing and capable to confirm written consent prior to enrolment after ample information has been provided
* Normal findings in the medical history unless the principal investigator considers an abnormality to be clinically relevant.
* Considered to be healthy by the principal investigator on the basis of extensive pre-study screening-

Exclusion Criteria:

Standard for healthy volunteers, including:

* Female subjects only: positive results in pregnancy test
* Female subjects only: lactating women
* Female subjects only: subjects who do not use or do not agree to use appropriate contraceptive methods during the study as defined in Note for Guidance on Non-Clinical Safety Studies for the Conduct of Human Clinical Trials for Pharmaceuticals (CHMP/ICH/286/95 modification)
Lymphadenectomy for Pancreatic Head Cancer: Standard or Extended?

The purpose of this study is to compare outcomes of patients undergoing standard or extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer


Eligibility Criteria:
Inclusion Criteria:

* Pathologic diagnosis of pancreatic ductal adenocarcinoma
* Signed the informed consents

Exclusion Criteria:

* Pathologic diagnosis of other pancreatic cancers
* Pre-operative anti-cancer treatment
* Recurrence patients
* Patients with contraindication(hepatic/ respiratory/ renal dysfunction, etc )
* Pre operative exam: Total bilirubin more than 250µmol/L
* AJCC stage IV
* Operation non radical
Comparative Effects of Motor Control and Isolated Strengthening Lumbar Exercises on Functional Outcomes in Patients with Chronic Low Back Pain

Comparative effects of motor control and isolated strengthening lumbar exercises on functional outcomes in patients with chronic low back pain

As there is an increasing population of low back pain because of the stress and workload that lead to poor posture. Poor posture leads to tightening of flexor muscles and weakness of lumbar extensors that knowns as lower cross syndrome and it will become the chronic low back pain if not treated on time. Most of the therapist only work on the pain management but not focus on the functional outcome of the patient so the isolated lumbar extensor strengthening exercises and motor control exercises should be evaluated to know the effectiveness in improving the functional outcome of patients.

To compare the effects of motor control and isolated strengthening lumbar exercises on functional outcome in patients with chronic low back pain. A randomized controlled trial with a sample of 35 patients with chronic low back pain will be taken from Physiotherapy OPDs of Madinah Teaching Hospital, Allied hospital, In motion physiotherapy clinic and The Physio Rehab clinic. Participants will be randomly divided into two groups using convenient sampling technique. Both groups will be experimental groups. Patients in Group A will do Motor control exercises. Patients in Group B will do isolated strengthening lumbar exercises. Hot pack will be applied for 15 minutes and Ultrasound therapy (1MHz) for 3-5 minutes as baseline treatment in both groups. Patients will be included based on inclusion and exclusion criteria. Assessment will be done by using NPRS and Oswestry disability Index Questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* LBP for more than 3 months

Both male and females.

Age between 20-50 years old.

Moderate to severe pain (VAS; 3-7)

Currently seeking care for LBP.

Exclusion Criteria:

* Spinal surgery

Pregnancy

Prostatectomy

Engaged in any sports activities

Any evidence of nerve root compression
Tacrolimus Adjustment by NFAT-related Gene Expression in Lung Allograft Recipients.

This is a non-interventional cohort study to assess a novel assay to detect excessive or insufficient immunosuppression from the drug tacrolimus in lung transplant recipients. The assay measures mean residual expression (MRE) of genes downstream of nuclear factor of activated T cells (NFAT), a transcription factor regulated by tacrolimus. The investigators will assess whether MRE levels identify subjects at risk for rejection (insufficient immunosuppression) or infection (excessive immunosuppression).


Eligibility Criteria:
Inclusion criteria:

The study will include lung allograft recipients within 2 months of transplantation at UCSF.

Exclusion criteria:

Subjects will be excluded who are (a) unable to provide consent or (b) if treating clinicians do not anticipate subject will start on tacrolimus. Recruitment and enrollment in this study are targeted equally between women and minorities and the study will not exclude any gender or racial/ethnic group. This study does not involve vulnerable populations.
Cognitive Changes With Gabapentin Treatment

This is a single-cohort, prospective, observational study evaluating the effects of gabapentin on cognition. The goal of the study is to determine whether there is a measurable change in cognitive function from baseline in patients who are prescribed gabapentin for the treatment of neuropathic pain.


Eligibility Criteria:
Inclusion Criteria:

1. Age between 18 and 85
2. Diagnosis of neuropathic pain
3. Patient report of average daily pain intensity in the last week \>3 on 0-10 Numerical Rating Scale (NRS).
4. Able and willing to sign an IRB-approved written informed consent

Exclusion Criteria:

1. Current pregabalin treatment
2. Patient has started taking a new pain medication, or has changed their pain medication dose, in the past 4 weeks.
3. Treatment with opioids exceeding 60mg MME.
4. Severe cognitive impairment that is documented in medical chart.
Initiation of CPAP for Newly Diagnosed OSA in Hospitalized Heart Failure Patients

The study aimed to examine the effect of Continuous Positive Airway Pressure (CPAP) initiation for newly diagnosed obstructive sleep apnea (OSA) in hospitalized heart failure patients on reducing 30-day hospital readmission rate through a clinical trial.

Following consent adult patients hospitalized with a medical history of heart failure and meeting study eligibility criteria will be screened for obstructive sleep apnea using the Ohio Sleep Medicine Institute Preoperative Questionnaire.

If the probability of sleep apnea is high (Sleep apnea clinical Score \>15) then participants will complete the Epworth Daytime Sleepiness scale and the Minnesota Living with HeartFailure questionnaire. The patient will then be evaluated by the sleep medicine team with a portable polysomnography monitor which has been shown to be equivalent to standard in-laboratory polysomnography. All participants with apnea-hypopnea index (AHI) ≥ 5events/h in whom sleep disordered breathing is confirmed by sleep medicine physician will be eligible for randomization.

Participants will be randomized into an auto-adjusting Continuous Positive Airway Pressure (CPAP) group or standard of care (control) group.

CPAP Arm (Intervention): CPAP education and discharge with auto-adjusting Continuous Positive Airway Pressure (CPAP) in addition to usual standards of clinical care for heart failure. The auto-CPAP group will be scheduled for follow-up with a phone call at 2 - 3 weeks post discharge, then in sleep medicine clinic at 1 month (+2 weeks) and 6 months (+2 weeks) to assess their progress on CPAP.

Standard of Care Arm (Comparator): CPAP initiation per standard of care based on approval by insurance company and DME company with management as per usual standards of clinical care for heart failure. This group will be scheduled for follow-up with a phone call at 2- 3 weeks post discharge and then in sleep medicine clinic at 1 month (+2 weeks) and 6 months (+2 weeks) to assess their progress.

Eligibility Criteria:
Inclusion Criteria:

* Hospitalized having a documented history of heart failure
* Anticipated hospitalization of more than 24 hours
* Subject has obtained a score of \> 15 on the Ohio Sleep Medicine Institute Preoperative questionnaire.
* Subject has an apnea-hypopneas index (AHI) of \> 5/h as confirmed by sleep medicine physician

Exclusion Criteria:

* The presence of any conditions that the investigator feels will interfere with the use of CPAP
Cryoanesthesia for Intravitreal Injections

The cryoanesthesia (CA) device is designed to provide anesthesia to a focal area on the surface of the eye immediately prior to intraocular injections.

The investigators plan to carry out a pilot study to collect preliminary data on the effectiveness of the cryoanesthesia (CA) device in minimizing the pain caused by intravitreal injections (IVT).


Eligibility Criteria:
Inclusion Criteria:

* Bilateral macular disease due to either exudative macular degeneration or diabetic retinopathy requiring bilateral intravitreal injections
* Have had at least one prior intravitreal injection
* Able to give informed consent

Exclusion Criteria:

* Unilateral disease
* Unable to provide consent
* Preexisting conjunctival, episcleral or scleral defects or disease
Coaching Language to Improve Endoscopy Training Quality

The goal of this randomized control study is to determine if the use of standardized coaching language by faculty trainers for teaching colonoscopy is associated with improved colonoscopy performance. The main questions it aims to answer are:

* If the use of standardized coaching language is effective in improving colonoscopy training?
* If the use of standardized coaching language influences the clarity of instructions by the faculty trainers during colonoscopy teaching Participants will take part in simulated colonoscopy teaching encounter using a virtual reality simulator for 1 hour in 2 different sessions 2 weeks apart.

Researchers will compare 2 groups of faculty trainers to to see if the standardized coaching language effects the colonoscopy training quality.


Eligibility Criteria:
Inclusion Criteria:

* Faculty members who are endoscopy trainers in either pediatric or adult gastroenterology division at University of Texas Southwestern Medical Center or Children's Medical Center, Dallas
* Fellow trainees in pediatric or adult gastroenterology division at University of Texas Southwestern Medical Center or Children's Medical Center, Dallas

Exclusion Criteria:

* Advanced endoscopy fellows
* Fellows beyond Post-Graduate Year-6 (PGY-6)
Motivational Interview for Daily Living Activities in Elderly People Undergoing Total Knee Replacement

Purpose: In this study, it was aimed to examine the effect of motivational interview on daily living activities on physical adaptation and quality of life in elderly people who underwent total knee replacement.it was aimed to examine the effect of motivational interview on daily living activities on physical adaptation and quality of life in elderly people who underwent total knee replacement.

Design: The research was planned as a pretest, posttest, randomized controlled study in order to determine the effect of the motivational interviews on the life quality and physical activity of old patients.

H1: After total knee replacement, the target for daily living activities is higher than the patients who applied the hand and those who did not.

H2: Patients with targeted daily living activities with total knee replacement begin to get used to it and begin earlier than those who do not.


Eligibility Criteria:
Inclusion Criteria:

* Those aged 65 and over,
* Having total knee replacement,
* The non-spiritual system (the peasant of the sick),
* A person who can read and write can cope at a level that prevents conversation,
* First time system add-on,
* They are viewed as agreeing to participate in the research.

Exclusion Criteria:

* Neurological (such as dementia) and psychiatric (such as schizophrenia) medical diagnoses that affect cognitive status
* Patients who did not participate in the motivational interviews and who wanted to leave the study were determined.
The Predictive Value of Hepatocyte Growth Factor and Soluble Receptor s-Met in Sepsis

To observe the changes of plasma hepatocyte growth factor and soluble receptor s-Met levels in patients with sepsis, and to explore its clinical significance.

90 patients who diagnosed as sepsis were included in this study. Then keep blood samples from these patients in the first day, the third day, detect the hepatocyte growth factor and soluble receptor s-Met level in plasma byenzyme-linked immuno sorbent assay. Record Severity of illness and survival status of every patient within 28 days. Objective to evaluate the correlation between the level of hepatocyte growth factor and soluble receptor s-Met in plasma and the prognosis of the patients.

Eligibility Criteria:
Inclusion Criteria:

1. Patients admitted to ICU diagnosed of sepsis(sepsis3.0 criteria)
2. Patients signing informed consent

Exclusion Criteria:

1. Age is less than 18 years old or more than 80 years old
2. Pregnant women
3. Patients with tumor、hepatitis、liver cirrhosis、acute myocardial infarction、chronic renal tubular nephritis、interstitial pneumonia、acute pancreatitis、systemic lupus erythenatosus、ulcerative colitis、crohn's disease、HELLP syndrome
4. Prothrombin time is extension in patients with after liver transplantation
5. Patients with chronic renal failure
6. Patients after kidney transplantation
Three-Dimensional Printed Customized Titanium Mesh for Mandibular Augmentation

Completely or partially edentulous patients suffer from resorption of the alveolar bone, they always seek rehabilitation which becomes challenging. Alveolar ridge augmentation is widely done now to offer these patients functional and esthetic restoration. Many techniques have been proposed to obtain good results of ridge augmentation. Titanium Mesh (TiMe) is widely used, also digital and computer-guided surgery now plays an important role to improve the techniques and results in ridge augmentation procedures.


Eligibility Criteria:
Inclusion Criteria:

* Patients will have a posterior mandibular atrophic ridge
* Distance between the crest of the ridge and the superior border of the inferior alveolar canal will be from 5 mm to 7 m
* Adequate inter-arch space

Exclusion Criteria:

* Patients who have any uncontrolled systemic disease contraindicated to oral surgery ( Diabetes, hypertension, and patients under chemotherapy treatment )
* Patients who have any relevant bone disease.
* Patients who are smokers
Traditional Medicine Use in Low Back Pain

Chronic low back pain (CLBP) is classified as one of the leading causes of disability worldwide. Furthermore, the painful experience of CLBP can be influenced by some already established factors, such as beliefs, self-efficacy, and kinesiophobia. Beliefs are pre-established ideas that can influence physical functionality, pain experience, social functioning, and adherence to CLBP treatment Clique ou toque aqui para inserir o texto. Among them is Traditional Medicine, a practice carried out by some populations that continue to trust their own popular medicine to meet their health demands. According to the WHO, Traditional Medicine (MT) or Popular Medicine (MP) is a practice reproduced in different cultures and based on beliefs, the sum of experiences and knowledge, whose objective is to prevent, treat or cure illnesses, whether physical or mental. This habit includes the use of home remedies, which are based on the manipulation of plant, animal, and mineral extracts for therapeutic purposes. Furthermore, it is important to point out that, as it is a chronic condition, individuals living with CLBP are strongly influenced by psychological factors, such as kinesiophobia (avoidance of exercise), catastrophizing (intensifying fear of movement, as they feel that pain is a threat), and low self-efficacy in processing and modulating pain, increasing levels of pain and disability. Also, in addition to this, socioeconomic level is one of the determinants of the incidence and intensity of chronic pain. In short, although the practice of TM has been recognized for decades, it is not known whether there is a relationship between this belief and the levels of self-efficacy, kinesiophobia and catastrophizing of individuals with CLBP in Northern Brazil. Therefore, this study aims to identify the use of TM and its impacts on the functional activities and quality of life of individuals with CLBP in the northern region of Brazil. This is a cross-sectional observational study. Individuals participating in this research will be invited to respond online to the questionnaire prepared by the authors of this study. Continuous data will be analyzed descriptively using mean and standard deviation; categorical data will be described in frequency form, and the normality of the data will be analyzed to identify the possibility of using parametric or non-parametric statistical tests.


Eligibility Criteria:
Inclusion Criteria:

* individuals over 18 years of age
* both genders
* diagnosed with chronic low back pain
* who have had pain for at least three months
* who are natives of the Northern region of Brazil

Exclusion Criteria:

* Individuals with low back pain of oncological origin
* recent traumas that may have caused the pain (such as falls, car accidents, and fractures)
* patients in the postoperative period
* bedridden patients.