cyrilzakka/clinical-trials huggingface dataset:
Effectiveness of Online Emotional Intelligence Training

The proposed study, titled "Effectiveness of Emotional Intelligence Training among Bangladeshi Youth," aims to evaluate the impact of a 4-week online Emotional Intelligence (EI) training program on the emotional competencies of Bangladeshi youth. Emotional intelligence, which encompasses skills such as self-awareness, self-regulation, social awareness, and relationship management, is crucial for personal and professional success, as well as mental well-being.

The study hypothesizes that targeted EI training can enhance emotional competencies, leading to improved social skills, decision-making, and mental health outcomes. This is particularly significant in the Bangladeshi context, where such programs are scarce, and youth face numerous societal pressures. The research will employ a quantitative, experimental design, comparing pre- and post-training EI levels between an experimental group (participants undergoing EI training) and a control group (participants not receiving the training).

Participants, aged 18 to 30 years, will be recruited from educational institutions across Bangladesh. The study will use the Bengali version of the Emotional Intelligence Scale to assess EI levels and a structured Personal Information Form to collect demographic data. The training program will consist of four weekly sessions, each focusing on a core EI component: self-awareness, self-regulation, social awareness, and relationship management. The sessions will be conducted by experts in public health and psychology.

Data analysis will involve descriptive statistics, t-tests, and regression analysis to evaluate the training's effectiveness and explore the influence of demographic variables. Ethical considerations, including informed consent and data confidentiality, will be strictly maintained.

This study is expected to provide valuable insights into the role of EI training in fostering resilience and mental health among Bangladeshi youth, contributing to healthier communities and informing future policy and program development.


Eligibility Criteria:
Inclusion Criteria:

1. being aged between 18 to 30 years
2. having a stable internet connection
3. agreeing to attend all four training sessions

Exclusion Criteria:

1. Previous experience in EI training
2. inability to attend the complete program
3. serious interruptions during the experiment
Chatbot-based Internet Intervention for Stress Among University Students (Stressbot)

The aim of this study is to verify the efficacy of chatbot internet intervention for reduction of stress and improvement of quality of life among university students through the enhancement of coping self-efficacy.

University students experience high stress levels and mental health risks. Research shows that increasing resources such as coping self-efficacy can reduce stress. Internet interventions can be successfully employed to deliver programs for improving university students' mental health.

The primary objective of this randomized controlled trial is to evaluate short- and long-term efficacy of coping self-efficacy enhancing intervention in reducing university students' stress and improving quality of life. The intervention will be delivered through a Facebook Messenger chat-bot. The secondary goal is to investigate acceptability of a chat-bot delivered intervention.

Participants will be recruited via social media and randomized to 1 of 2 groups: (1) experimental condition increasing coping self-efficacy with a 7-day program delivered through a chat-bot, or (2) waitlist control group. Outcomes include perceived stress and quality of life. Measurements will be taken at baseline (T1), immediately after intervention (T2), at 1 month follow-up (T3), and at 6 months follow-up (T4). Linear mixed effects model will be used to analyze the data.

The study aims to assess Stressbot's potential benefit for improving university students' well-being. Moreover, it will provide insight into feasibility of using chat-bots for delivering smartphone-based e-health treatments.

Eligibility Criteria:
Inclusion Criteria:

* Age of at least 18 years
* University students
* Mobile personal device with internet access

Exclusion Criteria:

* Not meeting at least 1 inclusion criteria
The Development of Novel Clinical Tests to Diagnose and Monitor Asthma in Preschool Children

The study will ascertain the ability of preschool lung function tests to distinguish healthy children from those with wheeze, and to differentiate phenotypes of wheezy children (high and low risk for asthma as defined by API) in order to predict response to therapy, and to explore the correlation between preschool lung function test results and symptoms, in order to develop objective methods for monitoring asthma.

In Canada, the most common chronic disease of childhood is asthma. Childhood asthma places a significant burden on the health care system (refn). No objective preschool asthma diagnostic tools exist, and the current gold-standard, the Asthma Predictive Index, does not provide information about lung function and symptom management. In this study, it is hypothesized that the lung clearance index (LCI), a value derived from the multiple breath washout test, will be the most sensitive, responsive discriminative test for preschool asthma. If it proves useful in the monitoring and diagnosis of preschool asthma, LCI has the potential to improve the clinical management and thus potentially significantly reduce hospitalization rates for preschool children suffering with asthma. In this unique data set, the investigators will also compare the relative utility of the forced oscillation technique (FOT) and preschool spirometry with the LCI in order to detect abnormalities amongst those children at high risk for preschool asthma. In addition, the impact of sleep apnea as a risk factor for and modifier of asthma will be investigated in this study. Furthermore, changes to the composition of the nasal microbiome during and after a wheezing episodes and the role of viral infections in wheezing exacerbations will be explored. Finally, the utility of new methods of diagnosing food allergy, such as the basophil activation test, will be examined in this Canadian cohort.

Eligibility Criteria:
Inclusion Criteria (Wheezing Subjects):

* 3 to 5 years of age (36 to 71 months)
* Diagnosis of Asthma made by a physician in the emergency department
* History of at least two other wheezing episode within the previous 12 months
* Received salbutamol within 4hrs before emergency department visit, during current emergency department visit, or was prescribed salbutamol at discharge from emergency department.

Inclusion Criteria (Healthy Controls):

* 3 to 5 years of age (36 to 71 months)
* Free of a respiratory infection for a minimum of 4 weeks prior to the testing visit

Exclusion Criteria (both subjects and controls):

* History or coexistence of renal, chronic pulmonary, cardiac, neurological or systemic disease
* Born pre-term (\< 35 weeks GA)
* Insufficient command of the English language
Low Dose Corticosteroid Infusion in Vasoplegia After Cardiac Surgery (CORTIVAS-CS)

Vasoplegia is an important determinant for adverse postoperative outcome and is observerd in 5% to 54% of patients undergoing cardiac surgery using cardiopulmonary bypass (CPB).

Postoperative vasoplegia is defined as a state with low systemic vascular resistance despite a normal or high cardiac output, and the need for vasopressor therapy.

Steroids attenuate the inflammatory response to cardiopulmonary bypass,but their effect on clinical outcomes is uncertain.

This is a double-blinded, randomized, clinical trial designed to determine the efficacy of low dose corticosteroid infusion in vasopressor free-days in vasoplegia after cardiac surgery.


Eligibility Criteria:
Inclusion Criteria:

* Cardiac surgery with cardiopulmonary bypass
* Norephinerine treatment in ICU with dose great or equal than 0,1 mcg/kg/min to maintain or restore a MAP over 70 mmHg for at least 30 minutes within 24 hours after surgery

Exclusion Criteria:

* Preoperative vasopressor use (within 72 hours prior to surgery)
* Preoperative steroids use (within 7 days prior to surgery)
* Presence of ventricular assist device other than intraaortic ballon pump
* Transplant procedures
* Emergency procedures
* Aortic repairs
* Congenital procedures
* Endocarditis
* Bacterial or fungal infection in the preceding 30 days
* Active neoplasia
* Pregnancy
* Recent history of gastrointestinal bleeding
* Allergy or intolerance to steroids
* Participation in other study
3D Evaluation of Powerscope Appliance in Treatment of Skeletal Class 2 Malocclusion

The study is aiming to evaluate the efficacy of Powerscope appliance in treatment of skeletal Class 2 malocclusion by three-dimensional image. Powerscope appliance is a hybrid fixed functional appliance used for treatment of Class II malocclusion with a retruded mandible.


Eligibility Criteria:
Inclusion Criteria:

1. Healthy post pubertal female patients of age range 14 to 16 years old, manifesting features of post pubertal cervical vertebrae maturational stages 4, 5 and 6 (deceleration, maturation, and completion).
2. Skeletal class 2 malocclusion of ANB angle greater than 4° with retrognathic mandible.
3. Class II division 1 malocclusion with at least an end-on Class II molar relationship.
4. Presence of all permanent dentition excluding third molars.
5. Good oral hygiene.

Exclusion Criteria:

1. History of previous orthodontic treatment.
2. Any systemic disease that could affect the orthodontic treatment.
3. Patients with periodontal diseases.
4. Patients with temporomandibular disorders.
ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery

The purpose of this study is to determine whether adding clopidogrel to aspirin after coronary bypass operation (CABG) improves graft patency, in patients that have preoperatively increased platelet activity(hypercoagulable) and therefore greater risk of graft occlusion( thrombosis).

Graft patency after CABG is reported to 80-90% worldwide 1 year following surgery. In the immediate period after surgery, and the following month, graft occlusion mainly occurs due to thrombosis.

Patients with platelet hyperreactivity have increased risk of thromboembolic events, including graft occlusion, myocardial infarction and stroke. Therefore intensifying the antiplatelet therapy in these patients, must be anticipated to have beneficial effects.

Hypercoagulable patients are identified with thrombelastography(TEG) as having a Maximal Amplitude(MA)\>69, thereafter randomized to either clopidogrel(3months) and aspirin or aspirin alone. At 3 months postoperative after surgery the coronary graft patency is assessed with Multislice CT scan.

Pre- and postoperatively, and then again at 3month followup, TEG and multiplate aggregometry are performed to assess platelet reactivity and resistance to aspirin and clopidogrel.

Eligibility Criteria:
Inclusion Criteria:

* Elective/subacute multivessel CABG
* Isolated CABG procedure, no concomitant surgery
* age \> 18 years
* Able to give informed consent

Exclusion Criteria:

* Myocardial infarction \<48h of surgery
* Prior CABG surgery within 1 month
* Cardiac Shock within 48h of surgery
* Atrial fibrillation
* Anticoagulation therapy with VKA
* ICH/TCI within 30 days
* Prior peptic ulcer· Platelet count \< 150 E9
* Ongoing bleeding
* Known platelet disease
* Allergic to aspirin or clopidogrel
* Liver disease with elevated ALAT/ASAT\> 1,5x normal
* Creatinine\> 0,120mmol/l
* Contrast allergy
* Alcohol or narcotics abuse
* Pregnancy
* Not able to give informed consent
* Geographically not available for follow up
MRL in the Upper Extremity

Objective: The aim of this study is to examine the feasibility and applicability of the MRL protocol for the upper extremity in Maastricht University Medical Center, and to examine the differences of the lymphatic system between lymphedema patients and healthy volunteers.

Study design: An explorative study of an MRL protocol for the upper extremity in Maastricht University Medical Center+.

Study population: There are two study groups. The first group (n=10) consists of patients with secondary lymphedema in the upper extremity. The second group (n=10) consists of healthy volunteers.

Intervention (if applicable):

All participants will undergo an MRL examination with the same protocol, developed in a previous 'proof of principle' study, in the Maastricht University Medical Center+.

After localizer scans, a T2-weighted sequence is used. Then a T1-weighted sequence will be made before the injection of contrast. After the injection of the contrast agent a T1-weighted sequences of the upper and lower arm are performed alternately.

Main study parameters/endpoints:

The primary outcome is to determine the feasibility and applicability of the MRL protocol by evaluating the images of the upper extremity in patients with secondary lymphedema and healthy subjects.

The secondary outcome is to assess the value of MRL in staging lymphedema.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or older
* informed consent
* BMI \< 30 kg/m2

Group A:

- Secondary lymphedema in the upper extremity

Group B:

- Healthy volunteers

Exclusion Criteria:

* Active skin infection/erysipelas in the arm.
* Known allergy for a contrast agent
* History of surgical intervention in the arm.
* Contraindications for MRI with contrast; pregnancy, metals, prostheses, renal insufficiency, claustrophobia
* Active cancer
* Distant metastases
Comparison of Septal Advancement Flap and Columellar Strut Effect on Nasal Tip

The aim of the study to compare and evaluate the effect of septal advancement flap in preserving and reshaping the nasal tip with columellar strut graft

The ideal tip support graft should support the exact position over time, avoid stiffness of a natural soft structure of the tip, be easily harvested typically septal cartilage, facilitate surgeon control of rotation and projection.

To address these desirable features the septal advancement flap (SAF) was developed. The septal advancement flap (SAF) is a rotational advancement flap of the superior and caudal aspects of the cartilaginous septum that enables the surgeon to create stable and accurate tip shape and position. This is a technically easy and reliable flap mainly applicable to primary rhinoplasty.

so investigator compare between this new technique and old one like columellar strut to know the effect on nasal tip

Eligibility Criteria:
Inclusion Criteria:

* Droopy nasal tip

Exclusion Criteria:

* severely deficient cartilaginous septum.
* previous nasal operations, history of cleft lip or cleft palate.
* bleeding disorders.
A Real World Study Evaluating the Long-Term Quality of Life of Tildrakizumab in Adult Patients With Psoriasis

This is a Phase 4 multicenter, uncontrolled open-label study design. There will be a total of 10 study visits at Screening, Baseline, Week 4, Week 8, Week 12, Week 16, Week 28, Week 40, Week 52 and Week 64, with subjects receiving tildrakizumab injections at Week 0, Week 4, Week 16, Week 28, Week 40, and Week 52. The total study duration will be approximately 64 weeks, excluding a screening period.


Eligibility Criteria:
Inclusion Criteria:

1. Subjects are non-immunocompromised males or females 18 years of age or older.
2. Subjects have ≥3% total body surface area plaque psoriasis.
3. Subjects are candidates for phototherapy or systemic therapy.
4. Subject must be diagnosed at least 6 months prior to entering the study.
5. Females must be surgically sterile, postmenopausal for \>5 years, or using a highly effective form of birth control (\<1% failure rate), for at least 30 days prior to test article exposure, with a negative serum pregnancy test.

Exclusion Criteria:

1. Subject is pregnant, lactating, or is planning to become pregnant during the study.
2. Subject is younger than 18 years of age.
3. Subjects with uncontrolled mental illness or active suicidal ideations based on baseline mental health questionnaire of choice.
4. Subject is known, or suspected of being unable to comply with the study protocol, in the opinion of the investigator.
5. Subject is currently enrolled in an investigational drug or device study.
Serum Resistin Level Following Non-surgical Periodontal Therapy in Diabetic Patients With Chronic Periodontitis

non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.

Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis.

Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.

Eligibility Criteria:
Inclusion Criteria:

* diagnosed with moderate to severe chronic periodontitis.
* Presence of a minimum of 15 natural teeth
* Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm
* agreement to participate in the study and sign a written informed consent

Exclusion Criteria:

* Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation
* A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months
* Pregnancy or use of contraceptives or any medication related to diabetes
* former or current smokers ˂ 5 years.
Aspirin Responsiveness in Women With Coronary Artery Disease

The purpose of this study is to measure the percentage of women with known Coronary Artery Disease (CAD) who are hyporesponsive to low dose (81 mg) aspirin.


Eligibility Criteria:
Inclusion Criteria:

* Able and willing to provide informed consent
* Women at least 45 years old of any race
* Taking 81 mg aspirin daily, for at least one month
* Diagnosed with known or suspected CAD with at least one of the following: angiographic evidence of at least one lesion \> 50% stenosis, history of significant elevation of biomarker troponin or CK-MB, or history of ECG changes in at least 2 contiguous leads characterized by either new ST depression \> 0.1 mV or transient (\<30 min) ST elevation \> 0.1 mV, coronary artery revascularization either by PCI or CABG

Exclusion Criteria:

* \< 45 years or \> 85 years of age
* Clinically unstable: hypotension defined as sustained systolic blood pressure of \<90 mmHg due to cardiac failure with associated symptoms, unstable or severe pulmonary edema, decompensated congestive heart failure, acute mitral regurgitation, acute ventricular septal defect, acute cerebrovascular event or transient ischemic attack (TIA) within the past six months, history of ventricular fibrillation and no implantable cardioverter defibrillator (ICD), sustained supraventricular tachycardia \> 30 seconds or associated with symptoms and no ICD, untreated complete heart block or untreated high grade secondary heart block
* Pregnant, planning to become pregnant, or breastfeeding
* Alcohol abuse or illicit drug abuse
* Allergy or intolerance to salicylates and/or excipients including a history of and/or active GI bleed
* Use of NSAIDs within seven days or planned regular use during the study
* Taking HRT or oral contraceptives within the past 30 days or planned use during study
* Use of heparin, warfarin, ADP inhibitors (clopidogrel, prasugrel, or ticlopidine), or glycoprotein IIb/IIa inhibitors within previous 96 hours or planned use during the study
* Use or planned use of any other medications known to interfere with AA-induced platelet function
* Currently participating in another investigational drug or device study
* Survival less than six months
The Registry Study to Compare the Cardiopulmonary Exercise Test Parameters Before and After Cardiac Rehabilitation in Patients With Chronic Total Occlusion of the Coronary Arteries

The aim of this study is to find strategy for treatment through comparing the cardiopulmonary exercise test parameters before and after cardiac rehabilitation in patients with chronic total occlusion of the coronary arteries.


Eligibility Criteria:
Inclusion Criteria:

* Age 19 and more
* Chronic total occlusion of coronary artery disease
* Cardiac rehabilitation

Exclusion Criteria:

* Not applicable