cyrilzakka/clinical-trials huggingface dataset:
Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital Versus Conventional Stabilization Splints

This randomized controlled research aimed to analyse the occlusion and assist the enamel wear before and after using of the stabilization splints produced by the conventional methods with the fully digitally fabricated stabilization splints.

Research question: Will the fully digital stabilization splint offer significantly better occlusal equilibration and enamel wear compared to the conventional stabilization splint? the primary outcome will be Digital occlusal analysis, and secondary outcome will be enamel wear assessment

This randomized controlled clinical trial investigates the effectiveness of fully digitally fabricated stabilization splints (FD-SS) versus conventionally manufactured stabilization splints (C-SS) in patients with temporomandibular disorders (TMD). The study focuses on two primary outcomes: digital occlusal analysis and enamel wear assessment over a 6-month period.

Participants are TMD patients aged 18-40 with stable jaw relations and intact dentition, randomly assigned (1:1) to the FD-SS or C-SS group. Digital occlusal analysis is performed using OccluSense technology, which captures bite force distribution and contact points dynamically and statically. Enamel wear is assessed quantitatively using an intraoral scanner paired with Geomagic Control X 3D software for surface matching analysis. Baseline and follow-up STL datasets are compared to quantify volumetric enamel loss with micrometer precision.

In the FD-SS group, fully digital stabilization splints are fabricated using a digital workflow that includes intraoral scanning, jaw tracking with Zebris JMA devices, and CAD/CAM design in Exocad software. Splints are manufactured using 3D printing technology. In the C-SS group, conventional splints are fabricated using alginate impressions, plaster casts, and manual adjustments on a semi-adjustable articulator.

This study aims to advance the understanding of digital technologies in managing TMD, providing evidence for their efficacy in improving occlusal balance and minimizing enamel wear.

Eligibility Criteria:
Inclusion Criteria:

1. 18-40 years old
2. complete dentition
3. intact tooth
4. no occlusal disorder
5. stable jaw relation
6. No ongoing dental therapy, such as orthodontic or prosthodontics treatment.

Exclusion Criteria:

1. pregnant/lactating women
2. temporomandibular joint lesions found on clinical palpation or medical imaging examination
3. dentoalveolar pathology or ongoing treatment related to TMD
4. jaw opening less than 3 fingers
5. patients with occlusal dysfunctions
6. Patients with severe or moderate periodontitis.
7. Unable to undergo examination or treatment due to the presence of a psychological or mental disorder.
8. Severe jaw functional limitations.
9. Removable dentures or partially dentate patients
10. Trauma of recent date towards face, head or neck
MRI Findings of Epiphyseal Growth Plate in Healthy Children

The purpose of the study is to determine if by using MRI changes can be identified changes early on in the knees of young children that may be at risk for developing osteochondritis dissecans. If MRI can identify changes then better council can be offered about the risks of future activity and treatment options.

Each subject will be asked to undergo an MRI at enrollment, six,12, and 18 months. Subjects will be monitored for evidence of osteochondritis dissecans in order to determine if we can identify it and then create a treatment program to allow these children to avoid developing definitive disease

Eligibility Criteria:
Inclusion Criteria:

6-10-year-old children with a sibling with known OCD and 6-10-year-old children with a known OCD in the contralateral knee

Exclusion Criteria:

Unable to undergo an MRI
Meaning of Life in HIV-infected Youths

Logotherapy has never been evaluated in HIV-infected teenagers. In this study, we will evaluate the meaning of life by using The Purpose in Life Test and the affect of logotherapy in HIV infected youth at HIV-NAT, Thai Red Cross AIDS Research Centre and King Chulalongkorn Memorial Hospital.

In the HAART era, HIV infected children can live longer and will grow up to become teenagers. However, some may develop psychosocial problems because they have lost family members, experienced poverty, social discrimination etc. Being a normal teenager is tough and is the most complex period of his/her life. This is the period when most teenagers will find their identity and reasons for living. Therefore it is believed that interventions may help HIV-infected teenagers better deal with life. For this study, logotherapy, a therapy that will help a person to discover his/her purpose in life, live meaningful life, and attain self-esteem was used. The success of the intervention was evaluated by using The Purpose in Life Test.

Eligibility Criteria:
Inclusion Criteria:

1. Age 16-24 years
2. HIV seropositive
3. HIV disclosed
4. Understand Thai language
5. Parent signed written informed consent

Exclusion Criteria:

1. Mental or psychological disorder or having active suicidal idea or attempt
2. Having no permanent address
Behavioral Economic Purchasing Decisions for Cigarettes of Varied Compositions

The purpose of this study is to determine whether the abuse liability of cigarettes with altered composition (cigarettes differing in composition; e.g., tar levels, amount of sugar, casings) is reduced relative to standard composition cigarettes.

The proposed study will determine the abuse liability of altered composition cigarettes compared to standard cigarettes using a behavioral economics abuse-liability approach. Behavioral economic demand analysis constitutes a comprehensive examination of drug reinforcement and abuse liability. Laboratory determination of cigarette consumption under various response requirements will occur before and after 3 weeks of at-home exposure, with participants randomized to cigarettes varying in composition to determine the role of experience on the abuse-liability of various cigarettes. Abuse liability will be assessed by 2 essential demand metrics: lower demand intensity and increased demand elasticity, as well as other demand metrics and subjective ratings of "liking". The study will also determine the degree to which altered composition cigarettes may substitute for standard composition cigarettes - testing whether an altered composition policy would achieve the goal of reducing standard cigarette consumption.

Eligibility Criteria:
Inclusion Criteria:

1. Age 18 years or older
2. Smoke at least five cigarettes per day
3. Have an expired carbon monoxide level of more than 8 ppm or a urinary cotinine level of more than 100 ng per milliliter
4. Have a Fagerström Test for Nicotine Dependence score of at least 5 upon screening

Exclusion Criteria:

1. The intention to quit smoking in the next 30 days
2. The use of other tobacco products in addition to machine-manufactured cigarettes on more than 9 of the previous 30 days
3. Use of "roll your own" cigarettes as an exclusive form of smoking
4. A serious medical or psychiatric disorder or unstable condition
5. Any positive toxicological screening for illicit drugs other than cannabis will be excluded
6. Women who are pregnant, plan to become pregnant or are breast-feeding
HDCT and Stem Cell Transplantation for Mantle Cell and Relapsed Low Grade Non-hodgkin's Lymphoma

Low grade lymphoma patients receive R-ICE reinduction therapy followed by allogeneic stem cell transplanation.

Low grade lymphoma patients receive R-ICE reinduction therapy followed by allogeneic stem cell transplanation if they have an HLA matched sibling, or an autologous transplant if they do not.

Eligibility Criteria:
Inclusion Criteria:

* indolent histology lymphomas after relapse 1 or 2 LVEF \> 50% Creatinine \< 150 umol/L bilirubin \< 30 umol/L wbc \>3.5X10\^9/L platelets \>100X10\^9/L other medical condition as controlled

Exclusion Criteria:

* pregnant lactating HIV positive CNS involvement by lymphoma other malignancy
Investigating the Effects of Mindfulness-Based Self-Compassion Training Given to Parents of Children with Cerebral Palsy on Parents' Self-Efficacy, Caregiver Burden, and Emotion Regulation

The purpose of this observational study is to learn the effects of Mindfulness-Based Self-Compassion Training given to parents of children with Cerebral Palsy. The main question it aims to answer is:

-Is Mindfulness-Based Self-Compassion Training effective on parents' caregiver burden, self-efficacy, and emotion regulation? Parents who receive self-compassion training will answer survey questions before and after the training.


Eligibility Criteria:
Inclusion Criteria(For parents):

* Having a child diagnosed with cerebral palsy between the ages of 1-18,
* Being literate,
* Not having communication problems,
* Being between the ages of 18-65.

Inclusion Criteria(For childs):

* Having been diagnosed with Cerebral Palsy,
* Being registered in a special education and rehabilitation center.

Exclusion Criteria:

* Caring for other dependents (elderly, disabled, etc.),
* Having a mental illness (major depression, psychosis, etc.),
* Having communication problems,
* Not continuing education.
Prevalence of SARS-CoV-2 Genome in Tears of Asymptomatic and Moderately Symptomatic COVID-19 Patients

To evaluate the prevalence of SARS-CoV-2 genome in patients with asymptomatic and moderately symptomatic COVID19.

Patients attending to the COVID19 screening facility of Paris South University hospital and willing to participate to the study will have both nasopharyngeal and conjunctival swab for SARS-CV-2 genome detection using PCR. The project will evaluate the prevalence of positive conjunctival swabs in patients with positive nasopharyngeal swab. These results will be corelated to symptoms of disease assessed with a standardized questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* Patients receiving diagnostic nasopharyngeal PCR for COVID-19 as part of the usual care
* Age ≥ 18.
* Information and signature of consent
* Affiliated with a social security scheme or entitled

Exclusion Criteria:

* Refusal to participate in the study
* Eye surgery less than 3 months old
* Unable to give informed consent
* No coverage through the health insurance system
* Patient under judicial protection
* Patient on AME
Effect of Coadministration of Ume Paste (Prunus Mume) and Ginger Powder

This study is designed to evaluate the effect of ume paste and ginger powder on glucose metabolism in prediabetic subjects.


Eligibility Criteria:
Inclusion Criteria:

* Fasting plasma glucose 105-125 mg/dL

Exclusion Criteria:

* Taking anti-diabetic drugs
* Taking drugs or functional food that may affect blood glucose level
* Pregnant or nursing a child
* Participation in any clinical trial within 90 days of the commencement of the trial
* Renal or hepatic dysfunction
* Heart disease
* History of severe disease and/or major surgery
The Effect of Theophylline in the Treatment of Bronchiectasis

Theophylline was well recommended in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. However, there is no supporting evidence for their efficacy in the treatment of bronchiectasis. Our hypothesis is that theophylline will play a role in bronchiectasis. Our purpose is to examine the efficacy and safety of 24 weeks treatment with theophylline in subjects with non-cystic fibrosis bronchiectasis.

For the reasons of lack of sufficient clinical trial evidences, there are no standard therapy recommendations for bronchiectasis. Currently the treatments for bronchiectasis are mostly based on experience gained from the treatment of COPD and cystic fibrosis(CF). The aims of treatment for bronchiectasis are to improve the health-related quality of life, to slow down the decrease of lung function, to reduce the exacerbation frequence and the mortality. The mechanism of treatment are including: treating the underlying disease; improving drainage of sputum; anti-infection; anti-inflammation; treating airway obstruction. A review written by Peter J. Barnes describes that as a bronchodilator in COPD, theophylline may relax human airways smooth muscle, have an anti-inflammation rols, and have an additional effect on mucociliary clearance. Besides, theophylline can improve the activity of histone deacetylase, which will reverse the resistant of corticosteroids. We hypothesis that theophylline will have the same effect in subjects with NCF-bronchiectasis as in subjects with COPD. Our trial may give an evidence of using theophylline in treatment of bronchiectasis.

Eligibility Criteria:
Inclusion Criteria:

* Patients between 18-70 years old with non-CF bronchiectasis ,free from acute exacerbations for at least 3 months.Stable phase of the disease.

Exclusion Criteria:

* Patients with a cigarette smoking history of more than 10 packs-year. Patients with COPD. Patients with traction bronchiectasis due to advanced fibrosis. Patients with known intolerance for theophylline. Patients with asthma. Patients with other disease disturbing outcomes of the trials. Patients without consent.
Evening Primrose Oil Efficacy in Second Trimester Abortion

efficacy of evening primrose oil in shortening the duration of induction in 2nd trimesteric missed abortion


Eligibility Criteria:
Inclusion Criteria:

* Primiparous women

Exclusion Criteria:

* Previous uterine incision( Cs, myomectomy,)
* Contraindications to medical or surgical uterine evacuations (eg, hemodynamically unstable, coagulopathy)
* Evidence of intra-uterine infection
* Rupture of fetal membranes.
* Intrauterine device in place.
* Allergy to prostaglandins or EPO
Total Body Irradiation Treatments for Patients Treated at European Institute of Oncology

Patients eligible undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplant.

Total Body Irradiation (TBI) is an oncological radiotherapy technique that has been used for several decades in patients undergoing bone marrow or peripheral stem cell transplantation.

The role of TBI is:

To suppress the recipient's immune system to prevent rejection of the donor's bone marrow, whether familial or non-familial.

To eradicate residual neoplastic cells following chemotherapy treatments.

TBI is typically employed in both neoplastic and non-neoplastic disorders affecting blood cell elements (e.g., acute and chronic leukemias, aplastic anemia, lymphomas, etc.), as well as other conditions such as neuroblastoma, Ewing's tumor, and pediatric sarcomas with a poor prognosis.

Treatment choice is usually established following multidisciplinary discussions, based on disease characteristics and stage, concurrent pathologies and pharmacological treatments, patient preferences, and functional aspects. Data collection related to radiotherapy plays a crucial role in understanding various clinical aspects of the treatment itself. The availability of data from an increasing number of patients will allow the identification of clinical situations or technical parameters of radiotherapy correlated with treatment tolerance and effectiveness, aiming to identify the best treatment for these oncological pathologies.

This project aims to collect data related to total body irradiation treatments for scientific dissemination with the goal of establishing the basis for evaluating achieved results over time and deriving from these elements useful for guiding the most effective treatment strategies and appropriate operational protocols.

Eligibility Criteria:
Inclusion Criteria:

1. Patients undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplantation.
2. Signed informed consent

Exclusion Criteria:

* Patients who do not undergo total body irradiation
Home Based Massage and Relaxation for Sickle Cell Pain

The purpose of this study is to compare the effects of in-home, family-administered massage and in-home relaxation training on measures of physical status and health care utilization in a sample of African American adolescents age 15 years and older and adults with chronic pain associated with sickle cell disease who have been randomly assigned to six sessions of either family-administered massage or progressive muscle relaxation training.


Eligibility Criteria:
Inclusion criteria:

* Medically diagnosed with sickle cell disease, including hemoglobin SS disease, hemoglobin SD disease, hemoglobin SC disease, or sickle-thalassemia
* Self-report of having experienced chronic pain related to sickle cell disease during the past 30 days.
* Availability of a family member or friend who agrees to be trained to administer massages if the participant is randomized to the massage arm of the study.

Exclusion Criteria:

* Sickle cell trait instead of sickle cell disease diagnosis.
* Diagnosis of disease in addition to sickle cell disease which requires regular use of pain medication. (Please note, regular use of pain medication for sickle cell pain is NOT an exclusion)
Assessment of Bone Micro-Architecture Using HR-pQCT

In the context of male osteoporosis, we hypothesize that regional changes in trabecular bone, as well as changes in cortical porosity will play a major role, and thus also affect bone strength. In developing therapeutics the response of individual compartments, regional variations post-therapy will have considerable impact on selecting the therapies as well as monitoring response to therapy. This study, a precursor to other therapeutic trials, will lay the ground-work for the future.

We will recruit 80 subjects who will be stratified into groups based on their T-scores. All subjects will be imaged at Baseline and 12 months. Measures of bone micro-architecture in the tibia and radius using peripheral computed tomography, bone strength measures through finite element analysis will be obtained at all time points. DXA measures at the spine, femur and forearm will be obtained as reference measures. In addition whole body DXA scans will be performed for assessment of body composition.

Eligibility Criteria:
Inclusion Criteria:

1. Men 50-85 years old
2. Patients must be willing to undergo a DXA scan.
3. Patients should be willing to undergo HRpQCT scan of the radius and tibia.

Exclusion Criteria:

1. Inability to tolerate CT scans
2. Use of medications known to impact bone and mineral metabolism:

   * use of a bisphosphonate or teriparatide in the last year or for \>12 months ever;
   * current calcitonin;
   * prednisone \>5 mg daily or the equivalent glucocorticoid for \>10 days in the last 3 months;
   * current testosterone therapy;
   * current thiazolidinedione (TZD);
   * current androgen deprivation therapy;
   * current use of an antiepileptic agent that alters hepatic vitamin D clearance;
   * use of thyroid hormone replacement with current thyroid stimulating hormone \<0.1 mIU/L
3. Disease known to affect bone (e.g., primary hyperparathyroidism, Pagets disease, clinically significant liver disease)
4. Illicit drug use or alcohol use \>3 drinks/day
5. Serum calcium \>10.2 mg/dL or calculated creatinine clearance \<30 mL/min
6. Weight \>350 pounds (the maximum weight limit of the DXA)
7. Hardware in the lumbar spine
8. History of bilateral hip replacement, or bilateral wrist or ankle fracture
Saeboflex Dynamic Hand Orthosis for Inpatient Rehabilitation Stroke Patients

The purpose of this study is to determine what the potential utility of the Functional Tone Management (F.T.M) Arm Training Program using the SaeboFlex in an inpatient stroke rehabiliation hospital

Therapeutic interventions for the recovery of hand function after a neurological injury have historically been very limited. A significant body of research now supports the use of an upper extremity retraining approach for functional recovery after neurological injury. Few therapeutic approaches offer any intervention specifically focused on grasp and release retraining. In an effort to address this deficit, the SaeboFlex dynamic hand orthosis was developed by occupational therapists. The F.T.M. Arm Training Program has been safely used by hundreds of occupational and physical therapists on over one thousand patients in outpatient neurological rehabilitation over the last 2 years. It is currently an accepted modality of treatment for the management of hand paresis in the acquired brain injury outpatient population. Two factors, other than the severity of the initial injury, have been clinically identified as having a significant affect on the outcomes achieved in F.T.M. Arm Training treatment. They are learned non-use and soft tissue shortening of the finger flexors. All treatment delivered to the subjects that partake in this study will be clinical care and the only research component of this study will be the assessment of outcomes. The purpose of this study is to explore the potential patient population that may qualify to use the SaeboFlex Dynamic Hand Orthosis as a therapeutic option in the inpatient population.

Eligibility Criteria:
Inclusion Criterion:

* All patients admitted to the Stroke Rehabilitation Program at the Kessler Institute for Rehabilitation locations (East Orange, Saddlebrook, and Chester).
* Approval from treating physician.
Polyunsaturated Fatty Acids (PUFA) Status and Cognitive Function in Healthy Young Adults

To date, the relationship between omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cognitively intact individuals has only been examined in a limited number of studies; it is at present unknown whether supplementation with n-3 PUFAs can improve cognitive function and mood in this population. Further to this, it still remains to be established whether a relationship exists between peripheral fatty acid status-reflective of dietary n-3 PUFA intake-and cognitive function in this population. The current study therefore aims to address this issue by exploring the relationship between serum PUFAs and specific cognitive functions in a sample of healthy adults. To this end, participants will complete a range of cognitive tasks evaluating performance across the domains of attention, memory and executive function. Self-report mood assessments will be included as secondary measures.


Eligibility Criteria:
Inclusion Criteria:

* Male/Female
* 18-35 years
* Healthy
* No herbal supplements/prescription medications (excl. contraceptive pill)
* Non smoker
* Native English speaker

Exclusion Criteria:

* BMI ≥ 30