cyrilzakka/clinical-trials huggingface dataset:
Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI)

Aortic coarctation is a relatively common cardiovascular condition with high associated mortality if not treated. Even with successful repair, however, close follow up is needed as late complications can result in significant cardiovascular morbidity. MRI, with is ability to provide both anatomic and hemodynamic information, is becoming the imaging option of choice for post-intervention surveillance. Time-resolved, three-dimensional phase contrast magnetic resonance velocity (4D Flow) profiling enables the acquisition of multidirectional blood velocity data. The technique is well suited for evaluation of blood flow patterns in the thoracic aorta. By comparing aortic flow patterns in patients status post coarctation repair with those of healthy volunteers using 4D Flow, this study intends to characterize abnormal flow patterns in these patients with the eventual goal of better understanding and predicting late complications so that preemptive intervention may be taken.

Given the potential use of 4D Flow for evaluation of other types of vascular pathology in the aorta and other vascular regions, we hope to investigate the use of the technique on a limited basis for a broader population of adult patients. Other research groups have had success evaluating peripheral stenoses, as well as intracardiac and intracranial blood flow patterns with 4D Flow.


Eligibility Criteria:
Inclusion Criteria:

Patients: primarily status post intervention for repair of aortic coarctation and undergoing routine MRI follow up, but also adult patients with other vascular pathologies undergoing routine MRI evaluation, who may be good candidates for 4D Flow blood flow analysis.

Healthy subjects: healthy members of the radiology residency program and staff at UCSF.

Exclusion Criteria:

Anyone else.
Intermittent Vibrational Force and Orthodontic Tooth Movement

The aim of this study is to compare the clinical efficiency of conventional fixed appliance orthodontic treatment with that supplemented by the daily application of cyclic forces to the dentition via a removable (AcceleDent) vibrational appliance. The primary outcome measure is rapidity of tooth alignment; whilst secondary outcome measures include pain and discomfort during treatment, rapidity of orthodontic space closure, changes in arch dimensions and root length.


Eligibility Criteria:
Inclusion Criteria:

* Subjects will be recruited from a sample of consecutive cases attending for routine fixed appliance orthodontic treatment with conventional pre-adjusted edgewise brackets that satisfy the following criteria: in the permanent dentition; a requirement for extraction of a premolar unit in each quadrant; incisor irregularity between 5-12 mm.

Exclusion Criteria:

* no medical contraindications; no craniofacial anomalies or cleft lip/palate;
Hybrid Brain Computer Interface for Control of Sensory - Motor Coupling in Post - Stroke Rehabilitation

HYBIS project aims to develop an innovative and unique hybrid Brain-Computer Interface (BCI) system. This BCI system is envisioned as a novel tool for targeted reinforcement of sensory motor coupling, specifically dedicated for upper-limb post-stroke rehabilitation.


Eligibility Criteria:
Inclusion Criteria:

* age over 18 years old at the time of enrolment
* history of cerebrovascular insult verified by computerized tomography or magnetic resonance imaging;
* stoke occurred not more than 6 months prior to study enrolment;
* subject need to be medically and neurologically stable determined by medical history and documented neurological examination;
* ability to understand, communicate and cooperate with the research team;
* ability to sit for at least 45 minutes and the ability to adhere to the study rehabilitation protocol.

Exclusion Criteria:

* any neurologic condition (beyond the stroke) or physical condition that impaired function of the affected arm
* a substantial cardiopulmonary or metabolic disorder or other major medical complication;
* history of seizures;
* moderate to severe hemispatial neglect or anosognosia involving the affected arm;
* severe sensory deficit;
* inability to understand, cooperate, and adhere to the study procedures;
* severe spasticity defined as Ashworth scale score of 4 in the affected arm;
* contraindication to stimulation system placement;
* nursing a child;
* pregnancy.
Effects of Mobile Game on Life Quality of Cancer Patients

The purpose of this study is to determine whether functional games can be used to improve the adherence and quality of life of breast cancer patients with chemotherapy.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with breast cancer
* Receiving breast cancer chemotherapy
* Patients who are using a smartphone and agree to use a mobile functional game

Exclusion Criteria:

* Patient with intellectual disability
* Diagnosed with congenital genetic disease
* Patients with a history of acquired brain injury such as cerebral palsy
* Developmental disorders, including autism
* Patients with language or learning disabilities
The Body Constitution and Quality of Life of Diabetic

Diabetic Mellitus is the fifth cause of death by the report of Department of Health in 2008, and it often cause the severity of other chronic diseases. Neuropathy, retinopathy and renopathy are the most prevalent complications of DM, and they often influence the quality of life.

300 patients with Diabetic neuropathy will be recruited in Taichung Veterans General Hospital endocrine and metabolism clinics. Body Constitution Questionnaire(BCQ), Diabetes Impact Measurement Scales(DIMS), Short Form -36(SF-36) will be asked to filled up, neurological examination (NE), AC sugar, HbA1c, lipid profiles, liver and kidney functions will be measured in order to evaluate the correlation between body constitution and quality of life on patients with diabetic complication.

Diabetic Mellitus is the fifth cause of death by the report of Department of Health in 2008, and it often cause the severity of other chronic diseases. Neuropathy, retinopathy and renopathy are the most prevalent complications of DM, and they often influence the quality of life.

Traditional Chinese Medicine was often prescribed to treat diabetic complications and improve the quality of life .But the study of objective evaluation of diagnostics of Traditional Chinese Medicine was few . It is important to analyze population of specific disease with well developed Traditional Chinese Medicine diagnostic tool with good validation and consistency.

300 patients with Diabetic neuropathy will be recruited in Taichung Veterans General Hospital endocrine and metabolism clinics. Body Constitution Questionnaire(BCQ), Diabetes Impact Measurement Scales(DIMS), Short Form -36(SF-36) will be asked to filled up, neurological examination (NE), AC sugar, HbA1c, lipid profiles, liver and kidney functions will be measured in order to evaluate the correlation between body constitution and quality of life on patients with diabetic complication.

Eligibility Criteria:
Inclusion Criteria:

* There is a history of diabetes and the injection or taking hypoglycemic agents.
* Aged 20 years of age, not limit to male or female .
* Consciousness clear, subjects are willing to sign consent after stating research purpose and process.

Exclusion Criteria:

* Took the Chinese medicine within the past month.
Mobile Phone Reminders (and Photovoice) for Routine Immunization in Nigeria - The MOPING Study

This study aims to implement and test the efficacy of photovoice, Short Messaging Service (SMS) and phone call reminders in improving childhood immunization coverage (uptake, timeliness and completion rates) and reducing incidence of vaccine-preventable diseases (VPDs) among infants in Nigeria

This will be a single-blind three-arm cluster randomized controlled trial involving post-partum mothers and/or caregivers of infants (age 0-12months) attending immunization clinics in 12 randomly selected Primary Health Care Centres (clusters) across Sokoto, Jigawa, Kano, Ogun, Oyo and Lagos States of Nigeria. Additionally, a photovoice methodology will be implemented in 6 community clusters (one in each State) involving group discussions between community members (pregnant women in their third trimester, parents/caregivers of infants age 0-12 months), community leaders, service providers and policy makers on benefits of timely immunization and consequences of non-vaccination. Parent-infant pairs will be followed up for 12 months during which SMS and phone call immunization clinic appointment reminders will be provided to mothers and/or caregivers in intervention arm 1, and photovoice intervention provided at study commencement to participants in intervention arm 2. Respondents in the control group would receive standard care (routine paper-based appointment scheduling alone). The investigators will document and compare immunization uptake (all doses and vaccines), timeliness of receipt and completion rates of scheduled immunization between the three groups, as well as incidence of VPDs between the groups using multivariate statistical analyses.

Eligibility Criteria:
Inclusion Criteria:

* Mothers/caregivers of healthy infants (age 0 - 12 months) who:

  1. Have a mobile phone access
  2. Received antenatal care and/or delivered their babies in a hospital
  3. Plans to receive immunizations at the selected PHCs
* Purposively-selected community sample of pregnant women in their third trimester, parents/caregivers of infants, providers, community gatekeepers and policy makers

Exclusion Criteria:

1. Parents of infants requiring hospital admission due to significant illness, congenital deformity/malformation and prematurity
2. Foreigners
Treatment for Post Acute COVID-19 Syndrome

Post-acute COVID-19 tinnitus has not been treated successfully. As tinnitus may be related to SARS-CoV-2 neurological manifestations. This study aims to investigate if the dopamine receptor antagonists can be used effectively treat COVID-19 induced tinnitus.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative viral pathogen leading to the COVID-19 pandemic. In 2022, after three successive waves of the pandemic, the majority of the human population has been exposed to the SARS-CoV-2 virus. During the two years since the pandemic ensued, multiple reports emerged of patients experiencing COVID-19 emergent symptoms lasting longer than 4 weeks since onset. Up to 15% of patients recovering from COVID-19 experience post-acute COVID-19 induced tinnitus .

To-date, post-acute COVID-19 tinnitus has not been treated successfully. As tinnitus may be related to SARS-CoV-2 neurological manifestations. This study aims to investigate if the dopamine receptor antagonist Pimozide can be used effectively treat COVID-19 induced tinnitus.

Eligibility Criteria:
Inclusion Criteria:

1. Diagnosed with subjective tinnitus post COVID-19
2. Tinnitus persists for at least 4 weeks
3. Prior history of mild or no tinnitus
4. 18 years or older
5. Any gender
6. Females of child bearing age must be on contraception

Exclusion Criteria:

1. Pregnant
2. Patients who participated in any interventional studies in the past 6 months
3. Patients with severe hepatic impairment on admission (alanine aminotransferase higher than fivefold the upper limit)
4. Patients taking any dopamine receptor antagonists
5. Patient having history of hypersensitivity to Pimozide
6. Patients unable to comply with the study schedule
7. Actively using cortiocosteroids
Early Initiation of a Strength Training Based Rehabilitation After Lumbar Spine Fusion Improves Core Muscle Strength

To analyze safety and the effects of early initiation of the rehabilitation. Including the objective measurement outcomes after lumbar spine fusion, based on the principles of strength training.

The 27 patients were recruited for the study, aged 45 to 70 years, who had undergone lumbar spine fusion. The patients were randomized in to two groups. The strength training group started rehabilitation 3 weeks after surgery. The patients exercised two times per week, over 9 weeks. The focus was on muscle activation of lumbopelvic muscles stabilization. The control group followed a standard postoperative protocol, where no exercises were performed at the rehabilitation stage. The functional outcomes and the plain radiographs were evaluated after 3 weeks and subsequently after 3 and 18 months after the surgery.

Eligibility Criteria:
Inclusion Criteria:

* Primary diagnosis of degenerative, low-grade isthmic spondylolisthesis or degenerative disc disease with or without spinal stenosis.

Exclusion Criteria:

* Previous lumbar fusion surgery, degenerative or idiopathic scoliosis, inflammatory disease, and history of malignancy.
Dose Escalation Study of Pasireotide (SOM230) in Patients With Advanced Neuroendocrine Tumors (NETs)

This study designed to determine the Maximum Tolerated Dose (MTD) for patients with advanced Neuroendocrine Tumors (NETs) and to characterize the safety, tolerability, Pharmacokinetics and preliminary efficacy of pasireotide LAR administered i.m. once every 28 days.


Eligibility Criteria:
Inclusion Criteria:

* ≥18 yrs old, histologically confirmed advanced well or moderately differentiated neuroendocrine tumor/carcinoma
* unresectable metastatic NET tumor with measurable disease
* life expectancy ≥ 12 weeks

Exclusion Criteria:

* Patients with CNS metastases who are neurologically unstable or requiring increasing doses of steroids to control their CNS disease
* patients with known hypersensitivity to somatostatin analogs
* patients with symptomatic cholelithiasis in the past 2 months
* patients with history of another known primary malignancy with exception of non-melanoma skin cancer or carcinoma in situ of uterine cervix
* patients with known history of hepatitis C or chronic active hepatitis B
* patients with diagnosis of HIV.

Other protocol-defined inclusion/exclusion criteria may apply
Immunophenotyping of Plasma Cells and Immune Effector Cells in Peripheral Whole Blood and Bone Marrow Samples From Multiple Myeloma (MM) Patients

The objective of this study is to evaluate the immune profile of plasma cells and immune effector cells in paired peripheral whole blood and bone marrow samples from MM patients by standardized flow cytometry. The quantitative and/or qualitative variation of these immune effectors according to the different status of myeloma pathology (diagnosis, relapse or refractory). It is interesting to assess the extent to which a particular immune profile is associated with a better therapeutic response for a given treatment.

In addition, the study will validate the stability of the samples between T0 (\< 4 hours after sampling) and T0 + 72 hours.

Study the biomarkers recorded on plasma cells and normal leukocytes including T lymphocytes (naïve, effectors and memories), B lymphocytes, Treg, NK, monocytes as well as their activation markers (CD25, PD-1) in paired bone marrow and blood samples. Validate the pre-analytical stability of the samples between T0 (\< 4 hours after sampling) and T0 + 72 hours.

Secondary objectives: Validate the strategy of quantification of receptors on plasma cells by direct labeling in flow cytometry. Validate a new method for measuring receptor occupancy by a drug. Validate the pre-analytical stability of the absolute quantitative expression of the receptors and the specific marker CD138 on samples between T0 (\< 4 hours after sampling) and T0 + 72 hours.

The study will be enrolling 20 patients.

Eligibility Criteria:
Inclusion Criteria:

* Multiple myeloma without treatment

Exclusion Criteria:

-
Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses in Healthy

The purpose of this study is to evaluate the safety and tolerbility of ascending multiple oral doses of AGG-523 in healthy subjects and in subjects with osteoarthritis.


Eligibility Criteria:
Inclusion Criteria:

* Healthy men or women, aged 18 to 40 years and subjects with osteoarthritis of the knee, aged 40 to 75 years.
* Women must be of non-childbearing potential, defined as surgically sterile with documentation of ultrasound.
* Must be nonsmoker or smoke less than 10 cigarettes per day.
Nausea and Vomiting In Patients Receiving Consecutive Days of Cisplatin

The purpose of this study is to observe the incidence of nausea with systemic chemotherapy that includes consecutive days (more than one day)of cisplatin medication.

Questionnaires are completed on week of chemotherapy treatment referred to as Dartmouth regimen.

Eligibility Criteria:
Inclusion Criteria:

* confirmed diagnosis metastatic melanoma
* 18 years and older
* undergoing chemotherapy with Dartmouth regimen
* medically stable to receive chemotherapy per physical and clinical laboratory tests

Exclusion Criteria:

* No medical conditions that interfere with assessment of nausea and vomiting during chemotherapy
* No cognitive disorder that impairs symptom assessment
* No other investigational agent
* Inability to swallow medications for nausea and vomiting
* No gastric outlet obstruction
Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease

The purpose of this study is to evaluate treatment in Gastroesophageal Reflux Disease (GERD) patients (aged 18\~75) with endoscopically proven GERD treated with AGSPT201 Tablet.

This study is 4,8 weeks, outpatient, multicenter, randomized, double-blinded, active drug comparative, therapeutic confirmatory clinical study to evaluate the efficacy and safety of AGSPT201 in erosive esophagitis patients.

Eligibility Criteria:
Inclusion Criteria:

* aged 18\~75 years
* Patients whose esophageal lesions graded over LA A grade (The severity of lesions is classified by LA classification)
* Patients whose typical reflux symptoms such as heartburn, acid regurgitation, acid reflux and esophagus irritation during the past 3 month
* Symptoms on at least 2 days of the past 7 days

Exclusion Criteria:

* PPI treatment within 4 weeks before dosing or treatment of H2 blocker, sucralfate, prokinase NSAID (except low dose aspirin) within 2 weeks before dosing.
* Patients whose history of GI tract resection or vagotomy.
* Barrett's oesophagus greater than 3cm in length and high-grade dysplasia.
* Acid irrelevant Heartburn and regurgitation.
* Zollinger Ellison syndrome
* Hypersensitive and/or allergy to Pantoprazole and/or other PPI
* Pregnancy and lactation
* peptic ulcer
* serious hepatic
* any other renal, cardiac or haematological disease.
* Patients participated any other clinical studies during the past 3 months.
The Efficacy and Safety of Topical Vitamin D Drop on Meibomian Gland Function in Patients With Meibomian Gland Dysfunction

In this randomized clinical trial, patients with Meibomian gland dysfunction aged 50 year and more will be enrolled. The Meibomian gland dysfunction diagnosis will confirmed by a cornea specialist. The enrolled patients will be randomly allocated to the treatment and placebo group. The patients in treatment group will receive topical vitamin D every 6 hours daily (25 Microgram/cc or 1000 IU). The control group will receive the same-shape packed drop without vitamin D. The patients in both group will receive the conventional treatment including hot compress and shampoo scrub.

The primary outcome is the change in Ocular surface disease index and 5-Item Dry Eye Questionnaire score assessed before the topical treatment and every one-months until 3 months. The secondary outcome measures are Tear breakup time, Schirmer test, Corneal fluorescein staining, Meibomian gland expressibility.

The grader and the patients will blind to the study group.


Eligibility Criteria:
Inclusion Criteria:

* patients aged more than 50 years old and suffering from dry eye caused by meibomian gland dysfunction.

Exclusion Criteria:

* Patients with Vitamin D deficiency
* Patients taking Vitamin D systemic Supplementation
* Patient with prior ocular surgeries within previous 6 months.
* Patient with other causes of dry eye, such as aqueous tear deficiency or ocular surface disease
UCLA Couples Counseling for Combat Veterans

A pilot intervention of an existing intervention adapted for the returning warfighter population: a couples treatment for PTSD, Structured Approach Therapy (SAT), which emphasizes reducing the PTSD avoidance/numbing symptoms that are corrosive in families.


Eligibility Criteria:
Inclusion Criteria:

* OIF/OEF/ OND veteran with at least one deployment
* In a cohabitating relationship for 6 months or longer
* Cohabitating 50% of the time or more
* Diagnosed with PTSD or meets the diagnosis criteria for PTSD as related to deployment experience (CAPS)
* Ability to make weekly appointments
* Willingness to commit to change

Exclusion Criteria:

* Receiving an evidence-based treatment for PTSD within the past 6 months
* Receiving couples therapy within the last 6 months
* Moderate or excessive physical violence within the past 3 months (CTS)
* Alcohol/substance dependence (SCID)
* Known domestic violence/abuse (CTS)
* Symptoms of psychosis within the past 3 months
* Unstable psychiatric medicine usage or on regimen less than 3 months
Psychiatry and Individual Liberties: a Study of Institutions Characterized by a Reduced Use of Coercion

Psychiatric establishments show significant disparities in terms of coercion: while some use it frequently, others use it only exceptionally. This project aims at a better understanding of the less coercive establishments, which are currently little investigated and whose study may allow to identify the levers of a psychiatry more respectful of individual liberties.

This study aims precisely at understanding the history of less coercive establishments, and at identifying the knowledge as well as the forms of organization, coordination and cooperation that are developed there. To do so, it will consist of an inventory of establishments and practices based on the analysis of scientific literature, and an intensive study of seven less coercive establishments (four establishments on the French national territory, three establishments in the Auvergne-Rhône-Alpes region). The study of these institutions and their environment, which mobilizes nursing research and sociology, is based on a methodological approach combining interviews with professionals and users, observations in the institutions and services, a documentary method, and analysis of data from the RIM-P, the SAE, and the institutions' databases.

Eligibility Criteria:
Inclusion Criteria:

* Professionals who worked in one of the seven establishments identified
* Ex-patients who were hospitalized in these establishments in the two years preceding the survey and whose condition is stabilized

Exclusion Criteria:

* People who refused to participate to the study.