cyrilzakka/clinical-trials huggingface dataset:
Post-ERCP Pancreatitis Severity Indication (PEPSI) Study

This study plans to directly address the problem of post-ERCP pancreatitis to gauge the various factors involved in its development and genetic variability in the immune response to an isolated pancreatic insult. In addition, the investigators hope to study markers of the early immune response to this injury and to develop a risk-assessment model.

Endoscopic Retrograde Cholangiopancreaticography (ERCP) is an important diagnostic and therapeutic tool in the management of pancreatic and biliary diseases. However, it carries up to 10% risk of developing acute pancreatitis, 10% of which will be severe. Current models to predict the severity of acute pancreatitis are incomplete and unable to prognosticate early in the course of the disease because they are based on biomarkers of late immune response. Recent findings suggest that polymorphisms in the gene coding for MCP-1 (Monocyte Chemotactic Protein-1) play an important role in the early immune response leading to either mild versus severe acute pancreatitis of various etiologies.

This study plans to directly address the problem of post-ERCP pancreatitis to gauge the various factors involved in its development and genetic variability in the immune response to an isolated pancreatic insult. In addition, we hope to study markers of the early immune response to this injury and to develop a risk-assessment model.

Eligibility Criteria:
Inclusion Criteria:

1. All people presenting for ERCP procedures.
2. Males and females of 14 years of age and older.
3. Willingness to participate in the study and sign the informed consent. (Children will require a representative to sign the informed consent).
4. People in whom therapeutic pancreatic interventions are planned during the ERCP procedure.
5. Intact papilla

Exclusion Criteria:

1. Persons unwilling to sign the informed consent
2. Disorientation secondary to irreversible organic brain damage.
3. Hemoglobin of less than 11 gm/dl in children of 10 years of age to puberty and hemoglobin of 12 gm/dl in pubertal males and females.
4. Mean corpuscular volume (MCV) of less than 77 in all children of 18 years or younger.
5. ERCP scheduled for stent change
6. Previous diagnosis of pancreatic cancer or cholangiocarcinoma
7. History of chronic pancreatitis
8. Active Acute Pancreatitis prior to ERCP (typical pain and amylase or lipase \>3 times UNL)or smoldering pancreatitis
9. History of Recurrent Acute Pancreatitis with chronic pain between acute attacks of \>5/10 more than 3 days per week.
10. Previous sphincterotomy
11. Post surgical anatomy
12. History of organ transplant
13. On medications for the treatment of HIV
Independent Walking for Brain Health

Physical activity interventions with older adults can improve brain health; however most interventions have been performed in gym-like settings that reach a small sector of the senior population. Since not everyone can access a gym, it is important to study whether brisk walking in real world environments can also help brain health. This study will use mobile health devices to help older adults independently walk for brain health, thus representing a critical step towards the dissemination of physical activity intervention programs aimed at preserving cognitive function in aging.

Physical activity interventions conducted in supervised settings (laboratories and group settings) with older adults have consistently shown improved cardiovascular and cerebrovascular health and improved cognitive function. What is lacking is the development of interventions that take place in real world environments and that take advantage of new technologies to help objectively track real time physical activity behaviors. Real world physical activity interventions have the potential to reach a larger segment of the population and to enhance maintenance after the intervention period ends. This study will develop a novel physical activity intervention using mobile health technologies to promote physical activity levels likely to affect cerebral blood flow and cognition in real world environments in cognitively normal older adults. A randomized controlled trial will be conducted with 30 participants being assigned to the mobile health physical activity condition (walking in free-living environments tracked via mobile health technologies) and another 30 to an education control condition (at home reading about healthy aging materials) for 3 months.

Eligibility Criteria:
Inclusion Criteria:

* Men and women between the ages of 65-80
* Ability to obtain a signed physician's clearance for participation in this study
* English-speaking as needed to complete cognitive testing and follow study procedures
* Cognitively normal (based on comprehensive neuropsychological assessment)
* No contraindications for Magnetic Resonance Imaging (MRI)
* Must be ambulatory and able to walk independently

Exclusion Criteria:

* History of head injury involving loss of consciousness within the past 6 months and/or history of severe traumatic brain injury
* Major neurological disorders (dementia, multiple sclerosis, epilepsy, etc)
* Chronic major psychiatric disorders (schizophrenia, major recurrent affective disorder)
* History of major vascular events (myocardial infarction, stroke, etc),
* History of diabetes
* History of falls in the last year resulting in hospitalization
* Unstable or poorly controlled medical problems e.g. heart failure, diabetes (poorly controlled or on insulin), uncontrolled hypertension, pulmonary disease with hypoxia or hypercapnia, significant liver problems or renal failure, treatment of cancer in the past 2 years (other than non-melanoma skin cancer), HIV positive
* Objective evidence of cognitive impairment based on neuropsychological assessment
Bronchiectasis: Evaluation of an Educational Intervention

A study of an educational intervention of primary care practice physicians to assist in the identification of patients who have Bronchiectasis and to assess the effectiveness of the specific didactic educational intervention targeting primary care physicians in the recognition of Bronchiectasis.

A pilot study will be conducted for the purpose of evaluating an educational intervention (Description in Appendix A). As part of the educational intervention, primary care physician(s) will be trained in the use of an algorithm to guide assessment of patients seen with a respiratory chief complaint, and who have not previously been identified as having a diagnosis of BE. We propose an evaluation of three primary care practice(s) to compare the number of patients identified in three three-month periods as having a diagnosis of BE.

The evaluation periods will be as follows: Period 1) the three-month period immediately following the intervention, Period 2) the three-month period immediately preceding the intervention, Period 3) the three month period starting one year prior to the intervention.

Eligibility Criteria:
Inclusion Criteria:

1. Respiratory is the chief complaint
2. Patient \> 35 years of age
3. Seen in practice for \> 12 months

Exclusion Criteria:

1) Prior diagnosis with bronchiectasis
Plasmatic Concentrations of Propofol and Remifentanil in Obese and Non Obese Patients.

This prospective monocentric phamacokinetics study aims to compare plasmatic concentrations of Propofol and Remifentanil required to target a specific range of monitored anesthesia and analgesia during sus-mesocolic surgery in obese and non obese patients.

Remifentanil and Propofol are administered intravenously as an opioid pain reliever and hypnotic pain reliever during anesthesia. Their advantages are numerous: short half-life allowing anesthesia and rapid awakening, little accumulation, allowing to adapt the level of anesthesia or sedation to each patient, few side effects.

Entropy° is an index derived from the electroencephalographic signal of patients, validated for the evaluation of the level of narcosis during general anesthesia.

ANI ° (nociception index analgesia) is an index using the ventilatory physiological variability of the sinus rhythm validated to monitor patient's analgesia during general anesthesia.

These non-invasive means of analgesia and sedation monitoring allows the clinician to ensure satisfactory levels of anesthesia by administering products at minimum effective doses.

The authors propose to determine whether, for a comparable target effect (analgesia and monitored sedation), plasmatic concentrations and administration rates of propofol and remifentanil necessary during general anesthesia for a comparable surgical stimulus are the same in populations of obese and non obese patients.

Eligibility Criteria:
Inclusion Criteria:

Obese patients group:

* Age ≥ 18 years old
* Severe and morbidly obese patients (35kg / m2≤IMC \<55kg / m2).
* Patients undergoing general anesthesia for laparoscopic susmesocolic surgery (bariatric surgery or cholecystectomy).
* Patients who have given their consent in the manner described by the public health law of August 9, 2004.
* Patients benefiting from a Social Security scheme.

Group of non-obese patients:

* Age ≥ 18 years old
* Patients with normal weight or slightly overweight (19 \<BMI \<30).
* Patients receiving general anesthesia for laparoscopic susmesocolic surgery (cholecystectomy).
* Patients who have given their consent in the manner described by the public health law of August 9, 2004.
* Patients benefiting from a Social Security scheme.

Exclusion Criteria:

* Patient refusal
* Age \<18 years old
* Protected adults and vulnerable persons
* Pace maker
* General anesthesia in the 24 hours preceding this surgery
* Proven or suspected dysautonomia
* Premedication by gabapentin Neurontin °
* Locoregional peri-medullary analgesia technique used concomitantly during the pre- and intraoperative period.
* Unbalanced dysrhythmic heart disease (AC / FA; extrasystoles; non-sinus rhythm)
* Pregnant or breastfeeding woman
* Intubation impossible planned
* Hypersensitivity to the products used
* Allergy to peanut or soy
Study of the Outcomes of Intraoperative Margin Assessment With MarginProbe

The combination of breast conserving surgery (lumpectomy) with radiation therapy has been shown to result in equivalent overall survival rates compared to mastectomy for the local treatment of breast cancer. As a result, the majority of patients diagnosed with breast cancer in the United States undergo lumpectomy as their primary surgical therapy. Multiple studies have demonstrated the association between positive lumpectomy margins and an increased risk of ipsilateral breast tumor recurrence, even with postoperative radiation. Studies report 20-40% of lumpectomy procedures result in one or more involved (positive) surgical margins, leading to the need for further surgery, emotional distress, poorer cosmesis, delay to adjuvant treatments, and increased cost. Current available intraoperative margin assessment techniques include specimen Xray, gross pathology, frozen section, and touch prep cytology. To reduce the incidence of positive margins, the MarginProbe (Dune Medical Devices, Caesarea, Israel) was developed to provide real-time, intraoperative assessment of the presence of tumor at the lumpectomy margin. In the current study, the investigators aim to determine the effectiveness of MarginProbe as an adjunctive tool to standard practice for intraoperative identification of tumor at lumpectomy margins, and its ability to reduce positive margins and decrease the need for additional surgical procedures.

In the current study, the investigators aim to determine the effectiveness of MarginProbe as an adjunctive tool to standard practice for intraoperative identification of tumor at lumpectomy margins, and its ability to reduce positive margins and decrease the need for additional surgical procedures.

Aims of the study:

Primary objectives

1. Determine positive margin rate following lumpectomy

Secondary objectives

1. Determine accuracy of intraoperative margin assessment with use of MarginProbe plus standard of care (gross pathologic examination and/or intraoperative specimen Xray) versus standard of care (gross pathologic examination and/or intraoperative specimen Xray) alone.
2. Determine impact of MarginProbe on total tissue volume removed
3. Determine the impact of MarginProbe on the need for additional surgical procedures.

Eligibility Criteria:
Inclusion Criteria:

1. Subjects able to read and understand the informed consent

Exclusion Criteria:

1. Subjects unable to read or understand the informed consent.
Prevalence of and Factors Associated With Metabolic Syndrome in Schizophrenia

Patients with schizophrenia are more likely to have metabolic syndrome compared to general population. The criterion for metabolic syndrome in Asian people including: elevated waist circumference (male ≥ 90cm, female ≥ 80cm), elevated triglycerides ≥ 150mg/dL, reduced HDL cholesterol: male \< 40mg/dL, female \< 50mg/dL, elevated blood pressure: ≥ 130/85 mmHg, elevated fasting glucose: ≥ 100mg/dL. Several factors have been found to be associated with metabolic syndrome in schizophrenia, e.g. age, antipsychotic drugs, smoking, family history of metabolic disorder, stress, and quality of life.

However, little is known about the prevalence of and factors associated in Asian. This study aimed to:

1. Identify the prevalence of metabolic syndrome in patients with schizophrenia.
2. Identify the factors associated with metabolic syndrome in patients with schizophrenia.

Patients with schizophrenia are more likely to have metabolic syndrome compared to general population. The criterion for metabolic syndrome in Asian people including: elevated waist circumference (male ≥ 90cm, female ≥ 80cm), elevated triglycerides ≥ 150mg/dL, reduced HDL cholesterol: male \< 40mg/dL, female \< 50mg/dL, elevated blood pressure: ≥ 130/85 mmHg, elevated fasting glucose: ≥ 100mg/dL. Several factors have been found to be associated with metabolic syndrome in schizophrenia, e.g. age, antipsychotic drugs, smoking, family history of metabolic disorder, stress, and quality of life.

However, little is known about the prevalence of and factors associated in Asian. This study aimed to:

1. Identify the prevalence of metabolic syndrome in patients with schizophrenia.
2. Identify the factors associated with metabolic syndrome in patients with schizophrenia.

Method This study is a cross-sectional study conducting at the Faculty of Medicine, Chiang Mai University. Eighty participants will be recruited with the inclusion criteria of having diagnosed with schizophrenia according to DSM-IV-TR and aged 18 years or over. The exclusion criterion is having organic brain syndrome.

Measurements PANSS CDSS WHOQOL-BREF-THAI

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of schizophrenia according to DSM-IV-TR
* Aged 18 years-old or over

Exclusion Criteria:

* Having organic brain syndromes
CPAP Titration Using an Artificial Neural Network: A Randomized Controlled Study

The purpose of the study is to determine the validity of the prediction model in reducing the rate of CPAP titration failure and in achieving a shorter time to optimal pressure

In order to derive the most effective pressure, CPAP titration is performed in the sleep laboratory during which the pressure is gradually increased until apneas and hypopneas are abolished in all sleep stages and in all body positions. The technique is however time consuming and labor intensive. Furthermore, the duration of the study may not be sufficient to attain this goal because of patient's poor ability to sleep in this environment or due to difficulty in attaining an appropriate pressure. A predictive algorithm based on demographic, anthropometric, and polysomnographic data was developed to facilitate the selection of a starting pressure during the overnight titration study. Yet, the performance of this model was inconsistent when validated by other centers. One of the potential reasons for the lack of reproducibility is the complex relation of behavioral processes with nonlinear attributes. In areas of complex interactions, the artificial neural network (ANN) has been found to be a more appropriate alternative to linear, parametric statistical tools due to its inherent property of seeking information embedded in relations among variables thought to be independent.

Comparison: time to achieve optimal pressure in the conventional technique versus the intervention model

Eligibility Criteria:
Inclusion Criteria:

1. patients 18 years of age and older,
2. documented OSA by sleep study defined as AHI \> 5/hr

Exclusion Criteria:

1. previously treated OSA,
2. unwilling to undergo a titration study,
3. unable or unwilling to sign an informed consent.
High Definition Endoscopy and Virtual Chromoendoscopy Versus Standard Resolution Endoscopy in Detection of Colon Polyps

Over the last years a number of new endoscopic imaging modalities have been introduced (high-definition and virtual chromoendoscopy). Given the theoretical advantage of these new imaging techniques, the investigators aimed to investigate their use for the detection of polyps during colonoscopy.


Eligibility Criteria:
Inclusion Criteria:

* referred for colonoscopy
* signed informed consent

Exclusion Criteria:

* subtotal colectomy
* known colorectal tumor or polyp prior to colonoscopy
* genetic predisposition to colon cancer namely FAP, HNPCC, Hyperplastic polyposis syndrome, juvenile polyposis, Peutz-Jeghers syndrome
* inflammatory bowel disease
* primary sclerosering cholangitis
Effects of Isotretinoin on the Growth Rate and Thickness of the Nail Plate

The nail is an important skin appendage which can provide information about the person's overall health status in addition to having several important functions such as protection, tactile sensation, grasping. Many nail abnormalities which can have considerable psychological impact are side effects of drug administration. Retinoids have various effects on nails. Although isotretinoin as a retinoid has been associated with both decreased and increased nail growth, the great majority of such associations are not evidence-based. So, it was aimed to investigate the effects of isotretinoin on morphology, growth rate, and thickness of the nail plate.

Isotretinoin has various side effects that affect many organ systems. Some side effects such as nail changes, which do not require treatment cessation, can limit the use of isotretinoin by impairing the patient's quality of life. Although it is known that isotretinoin has various effects on the nails, there is very limited data on effects of isotretinoin on the nails. Therefore, it was aimed to investigate the effect of isotretinoin on the morphology, growth rate, and thickness of the nail plate. The patients aged 18-45 that were planned to begin treatment with isotretinoin for acne in the outpatient clinic and a control group consisting of healthy volunteers are planned to be included in the study. A dermatological examination of skin and nails is conducted in all participants. Isotretinoin treatment at 0.5 mg/kg per day in 2 divided doses will be started to patients with acne. The length and thickness of nail plate are measured by digital caliper before isotretinoin treatment, and repeated during the control visits of the participants at 30 day intervals for 6 months. All the examination and measurements are carried out in both groups.

Eligibility Criteria:
Inclusion Criteria:

* The patients that were planned to begin treatment with isotretinoin for acne

Exclusion Criteria:

* Having known diseases (dermatological or systemic disorders) affecting the growth rate and thickness of nail plate
* Using systemic or topical drugs with known effects on nail
* Having traumatic nail abnormalities (onychotillomania, nail biting, habit-tic deformity)
* Having no visible lunula
* Describing any trauma (including cutting or filing nails) between the two measurements
Ketamine Prevent POCD

Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent. In present study investigators hypothesized that low dose ketamine would prevent the cognition decline after orthopedic surgery in aged patients.


Eligibility Criteria:
Inclusion Criteria:

* Elder than 60
* Easily communicated with Chinese
* Selected to kneel or hip replacement
* Agree to take part into this clinical trail

Exclusion Criteria:

* Existing cerebral disease， or have a history of neurological and psychiatric disease including AD, stroke and psychosis
* Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
* Several audition or vision disorder
* Preoperative systolic Blood pressure over 190mmHg or diastolic pressure \>100mmHg
* Existing a history of hyperthyroidism
* Patient with glaucoma
* Unwillingness to comply with the protocol or procedures
Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score: Prospective, Randomized Trial

The aim of this study is to evaluate the effects of three different postsesarean analgesia techniques, including instillation of local anesthetic into the peritoneum with infiltration into all layers of the anterior abdominal wall, intrathecal morphine injection with local anesthetic, and quadrotus lumborum type 1 block, on the postoperative recovery of women using the ObsQoR-10 score..

This study will be planned on women who will undergo elective cesarean section surgery with neuraxial anesthesia, after obtaining ethics committee approval and written informed consent from the patients.Parturients will be randomized by the statistician using a computerized random numbers table and divided into 3 equal groups: Group IPLA + LWI, Group QLB 1 and Group M.Postoperatively, patients' ObsQoR-10 scores will be evaluated and recorded at the 24th and 48th hours.

Eligibility Criteria:
Inclusion Criteria:

* Elective cesarean section under spinal anesthesia
* Full-term singleton pregnancy
* Agree to participate in the study
* American Society of Anaesthesiology Score of II

Exclusion Criteria:

* Contrindication for neuraxial anesthesia
* ASA≥3, diabetes, preeclampsia, cardiovascular disease, chronic pain and neuropathic pain
* Age\< 18 or \> 50
* Multiple pregnancy
* Presence of psychiatric diseases
* Gave a history of allergic to any medication in the study protocol
* Gave a history of chronic pain
* Unable to consent
* BMI\>35 kg/m2
* Those who were given opioids during the operation due to intraoperative pain
* Those who have had previous abdominal surgery
* Patients who failed spinal anesthesia and switched to general anesthesia
* Those who have excessive bleeding or uterine atony during the operation
* Does not understand VAS
* Those who have a drain placed in the area to be infiltrated
* Gave a history of drug addiction
Fecal Microbiota Transplantation and Newly Diagnosed Ulcerative Colitis (UC)

In this FinUC study we are trying to find out the efficacy and safety of the Fecal microbiota transplantation (FMT) in newly diagnosed active ulcerative colitis patients. The study group with newly diagnosed active ulcerative colitis receive an FMT via colonoscopy from a tested general donor, frozen and thawed from a fecal bank at week 0 and at week 4 as an enema at the study nurse´s visit. The control group will be given colored water. The main aim of the FinUC study is to determine how the FMT change of the gut microbiota composition in newly diagnosed active ulcerative colitis patients. The other aim is to determine efficacy and mechanisms of fecal microbiota transplantation.


Eligibility Criteria:
Inclusion Criteria:

* Over 18 years
* Active newly diagnosed colitis (Mayo score \<11)
* Signed informed consent

Exclusion Criteria:

* Fulminant severe colitis (Mayo score 11-12 or Truelove and Witts criteria)
* Gastrointestinal infection
* Pregnancy
* Antibiotic therapy at the baseline
* On-going probiotic medication
* Unable to provide signed informed consent