cyrilzakka/clinical-trials huggingface dataset:
Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Survey

To determine if women can understand the instructions, carry out the test, and interpret the test results. Women will be recruited to complete a test instruction and comprehension assessment and a usability assessment.

To determine if women can understand the instructions, carry out the test, and interpret the test results. Women will be recruited to complete a test instruction and comprehension assessment and a usability assessment. Study participants will be a convenience sample of women seeking health services. Participants will first be asked to review the instructions for the Congo Red Dot Test and complete a short written questionnaire that assesses their comprehension of the test instructions. Participants will then be asked to perform the test using a test control and to interpret the results obtained by answering a second written questionnaire. After the woman performs the test, a healthcare provider will use a matched control to perform a second test.

Eligibility Criteria:
Inclusion Criteria:

* Eligible to consent for research
* Able to read Spanish well enough to read the test instructions
* Able to give informed consent

Exclusion Criteria:

* None
Safety and Immunogenicity of a Commercially Available Influenza Vaccine (Formulation 2006/2007) When Administered to Subjects 18 Years of Age or Older

The present study aims to evaluate safety and immunogenicity of one dose of a commercially available Surface Antigen, Inactivated Influenza Vaccine, Formulation 2006-2007, in non-elderly adult and elderly subjects.


Eligibility Criteria:
Inclusion Criteria:

* Male and female subjects 18 years of age or older

Exclusion Criteria:

* any auto-immune disease or other serious acute, chronic or progressive disease
* hypersensitivity to eggs, chicken protein, chicken feathers, influenza viral protein, neomycin or polymyxin or any other component of the vaccine
* known or suspected (or high risk of developing) impairment/alteration of immune function
* within the past 7 days any acute disease or infections requiring systemic antibiotic or antiviral therapy
* history of neurological symptoms or signs, or anaphylactic shock following administration of any vaccine
The Effect of Education Given to Primiparous Pregnant Women on Parental Self-Efficacy and Mother-Infant Attachment

This research will be carried out in a quasi-experimental design to determine the effect of maternity care and neonatal care training given to primiparous pregnant women on parental self-efficacy and mother-infant attachment in the postpartum period.

Research Hypotheses:

H0: There is no difference in parental self-efficacy and mother-infant attachment in the postpartum period between pregnant women who received training during pregnancy and did not.

H1: There is a difference in parental self-efficacy and mother-infant attachment in the postpartum period between pregnant women who received and did not receive education during pregnancy.

The number of people to be included in the study was made with the power analysis made considering the previous studies. With the G \* Power (3.1.9.7.) Program, the number of samples for each group was determined as n = 34 at 80% power, 5% error and 95% confidence interval. Considering the losses in data collection, 20% was added to each group and it was decided to recruit a total of 80 people, 40 people for the experimental group and 40 people for the control group.

Pregnant women included in the research sample will be divided into two groups as experimental and control groups. Data will be collected by sending via an online questionnaire created by the researchers. Before the online questionnaire is sent to the experimental and control groups, the experimental-control days will be determined randomly by a lottery drawn by a third person (blinding). Pregnant women who agree to participate in the study will be assigned to the experimental and control groups according to the determined days.

The data obtained in the study will be analyzed using the SPSS (Statistical Package for Social Sciences) for Windows 22.0 program. Significance value will be considered as p \<0.05.

Number, percentage, mean and standard deviation will be used as descriptive statistical methods in the evaluation of data. Pearson correlation and regression analysis will be applied among the continuous variables of the study. The t-test will be used to compare the quantitative continuous data between two independent groups, and the One-way Anova test will be used to compare the quantitative continuous data between more than two independent groups. After the Anova test, the Scheffe test will be used as a complementary post-hoc analysis to determine the differences.

Eligibility Criteria:
Inclusion Criteria:

* Being at 36-40 weeks of gestation
* Being her first pregnancy
* Being literate
* Being over the age of 18

Exclusion Criteria:

* Not in the 36-40 gestational week
* Not a first pregnancy
* Illiterate
* Under 18 years old
Role of BCG as Booster Vaccination

The BCG (bacillus Calmette-Guerin) vaccine is used for the protection against tuberculosis.

Apart from it's protective effect against tuberculosis BCG vaccine has been shown to have non-specific effects on the innate immune system and is in epidemiological studies associated with reduced mortality due to infectious diseases.

Several studies have shown that BCG can boost the effect of other vaccines. The present study aims to investigate the boosting effect of BCG on the response to typhoid fever vaccine (TFV) and to assess the non-specific effects of BCG on the innate immune system at early timepoints by vaccinating volunteers with either TFV alone or BCG followed by TFV 14 days later.

The study hypothesis is that when BCG is given 14 days before typhoid fever vaccine a better vaccination result in terms of antibody production will be accomplished against typhoid fever due to the effects of BCG on the innate immune system.


Eligibility Criteria:
Inclusion Criteria:

* Healthy volunteers

Exclusion Criteria:

* Born in Salmonella typhi endemic country
* Pregnancy
* Oral medication except anticonceptive drugs
* Previous vaccination with BCG and/or TFV
Glycemic Response of Co-ingesting Carbohydrate and Amino Acids

The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).

Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.

Eligibility Criteria:
Inclusion Criteria:

* Male
* Chinese ethnicity
* Age between 21-50 years
* Body mass index (BMI) between 18-24.9 kg/m2
* Waist circumference ≤ 90 cm for men
* Normal blood pressure (\<120/80 mmHg)
* Fasting blood glucose \< 6 mmol/L

Exclusion Criteria:

* dislike the consumption of Essence of Chicken
* participating in competitive sports
* allergic to amino acids and rice
* metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)
* Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency
* on prescription medication
* smokers
Post-marketing Study of KamRAB Administered as a Single Dose With Active Rabies Vaccine in Children Exposed to Rabies

The primary purpose of this study is to confirm the safety of KamRAB (Human Rabies Immunoglobulin) in children ages 0 months to \<17 years, when administered as part of post-Rabies Exposure Prophylaxis (PEP).


Eligibility Criteria:
Inclusion Criteria:

* Healthy children (male and female) ages 0 months to \<17 years.
* Have been exposed or possibly exposed to rabies.
* Are indicated to receive post-exposure prophylaxis (PEP) against rabies infection.
* Have documented informed consent from the child's parent(s) or legal guardian(s) and assent from the child if appropriate.

Exclusion Criteria:

* History of previous administration of rabies vaccine or human rabies immune globulin (HRIG)
* Rabies exposure or possible rabies exposure more than seven days prior to initiation of PEP, or timing of exposure unknown
Ultrasound-guided PNB and DPNB for Pediatric Distal Hypospadias Surgery

Hypospadias repair is a urological surgical operation that is very painful in the postoperative period and requires long-term analgesia. A dorsal penial nerve block (DPNB) and pudendal nerve block (PNB), which are regional anesthesia techniques for this operation, are used to provide postoperative analgesia.

The regional anesthesia techniques used for postoperative analgesia in hypospadias repair include the peripheral nerve blocks of pudendal nerve block (PNB) and dorsal penile nerve block (DPNB). Ultrasound (US) has recently become increasingly popular in regional anesthesia practice and is used to aid these two peripheral nerve block applications in various pediatric urological procedures. US-guided DPNB has been shown to provide effective and long-term analgesia when compared to caudal epidural block in a recent study on hypospadias surgery in the pediatric population.

Eligibility Criteria:
Inclusion Criteria:

* Male patients aged between 1-7 years
* American Society of Anesthesiologists (ASA) I-II group
* Distal hypospadias surgery
* Able to communicate in Turkish
* Willing to participate to the study (parents and children)

Exclusion Criteria:

* Less than 1 or more than 7 years of age
* A neurological deficit, bleeding diathesis, or a history of local anesthetic allergy; an infection or redness in the injection area, congenital low back anomaly, liver disorder, a psychiatric disorder, mental retardation, or communication problems detected during examination
* Unwilling to to participate to the study ((parents or children)
the Indications and Clinical Efficacy of Pelvic Organ Prolapse Surgery

One thousand patients with stage\>2 POP are recruited. The patients are all received surgeries,such as transvaginal synthetic mesh surgery, the sacral fixation, tissue repair surgery and colpocleisis. The patients with POP who have not undergone surgery are excluded. Postoperatively, the investigators investigate the indications and clinical efficacy of pelvic organ prolapse surgery.

Postoperatively, the investigators analyze the patients' subjective and objective recurrent rates. The investigators compare the quality of life by filling out the preoperative and postoperative scoring questionnaires (PISQ 12, PFDI-20, PFIQ-7).The electrical physiological changes will be focused on. The investigators also use Overactive Bladder Symptom Score(OABss) to assess the lower urinary tract symptoms.

Eligibility Criteria:
Inclusion Criteria:

* The patients with stage\>2 POP are recruited.The patients are all received surgeries, which include transvaginal synthetic mesh surgery, the sacral fixation, tissue repair surgery and colpocleisis.

Exclusion Criteria:

* The patients with POP who have not undergone surgery are excluded.
COVID-19 Seroprevalence Study in French Guiana

Serological surveys measuring anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies in the population to assess the extent of the infection and the COVID-19 immunity of the population in French Guiana.

Serological surveys measuring anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies in the population to assess the extent of the infection and the COVID-19 immunity of the population in French Guiana.

This study is a interventional study that present minimal risks and constraints.

The results of the study will allow estimation of COVID-19 virus infection, severity and attack rates, as well as inform public health responses and policy decisions in the French Guiana territory.

Eligibility Criteria:
Inclusion Criteria:

* Person going to a prevention and care center or medical biology analysis laboratory as part of the care, regardless age, regardless of an acute or previous infection with COVID-19;
* State of health compatible with a blood sample as defined in the protocol

Exclusion Criteria:

* Inability to consent
* Person under guardianship or curatorship
* Known pathology or a health problem contraindicated with the collect of blood sample.
Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas

The rationale for the proposed pilot study is to investigate the ability of PET-CT with F18-choline to detect and locate the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory MIBI (Tc-99m sestamibi) and cervical ultrasound, in order to avoid unnecessary bilateral cervical exploration.


Eligibility Criteria:
Inclusion Criteria:

* Patient aged 18 years or more;
* Patient with a primary hyperparathyroidism and witj a negative or non-contriburatory MIBI parathyroid scintigraphy and neck ultrasonography, for which surgical resection is planned;
* Confirmation of the diagnosis of primary hyperparathyroidism on laboratory tests
* Affiliate to a social security system;
* Patient written informed consent.

Exclusion Criteria:

* Patient deprived of liberty, under guardianship;
* Any medical or psychological condition witch could compromise the capacity of the patient to participate in the study;
* Pregnant or breastfeeding
Platelets to Lymphocytes Ratio and Monocytes to Lymphocytes Ratio as Predictors of Response to Treatment in Cirrhotic Patients With Spontaneous Bacterial Peritonitis.

Spontaneous bacterial peritonitis (SBP) is a serious complication of ascites that can lead to death and can be described as an acute infection of ascites without any certain source of infection SBP is considered the most common infection in cirrhotic patients with ascites. SBP is diagnosed by the presence of ≥250 polymorphonuclear leukocyte (PMNL)/mm3 in the ascetic fluid in absence of surgical and treatable causes of intra-abdominal infections .

SBP has many pictures of clinical presentation SBP can be asymptomatic and patients pass unnoticed or can discovered accidentally may have local symptoms and signs of peritonitis such as abdominal pain, and tachypnea or may present with signs of deteriorated liver function in form of gastrointestinal bleeding, shock and renal failure An increasing amount of studies have demonstrated that peripheral blood neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) are indicators of systematic inflammatory response and are widely investigated as useful predictors of the clinical outcomes in various diseases .


Eligibility Criteria:
Inclusion Criteria:

* Cirrhotic patient with ascites.
* Un treated SBP

Exclusion Criteria:

* Ascites without cirrhosis (malignant ascites, chylous ascites, etc...).
* Tuberculous peritonitis.
* Secondary bacterial peritonitis due to any surgical cause.
* Sepsis rather than SBP.
* Patients with unrelated infections e.g. skin, chest infection, etc.
* Patients started treatment of SBP.
* Patients on prophylactic antibiotics for recurrent SBP prevention .
* Patients declining to provide informed consent.
* Patients with hepatocellular carcinoma on top of cirrhosis.
* Patients with other malignancy or any immunological disease
EPIC (Evaluating Perioperative Ischemia Reduction by Clonidine)

In Canada 1 patient in 200 dies within 30 days of an operation. More than half of these deaths are the direct result of a heart related complication. This cause of death happens 4 times more often than in the same people who do not have an operation. We do not have an effective way to stop these heart attacks. Stress causes the heart rate and the blood pressure to go up which causes the heart to work harder and may be the reason for some heart attacks. One group of drugs that stops the heart from working harder and decrease the number of heart related complications are BETA-BLOCKERS. We wish to add another drug, which has been shown to reduce heart rate and blood pressure, will reduce the number of heart attacks after an operation. CLONIDINE has been shown to reduce heart attacks after operations. Since we know it is not a good idea to stop beta-blockers we want to see if giving clonidine as well as a beta-blocker is safe and has the desired effect of decreasing the number of heart attacks. We want to find out how good the combination of these two drugs are at decreasing the number of heart attacks.

Hypothesis: The addition of clonidine to chronic b-blockade will reduce mortality and cardiac morbidity among intermediate-to-high risk patients undergoing non-cardiac surgery.


Eligibility Criteria:
Inclusion Criteria:

1. Age ≥ 45 years
2. Current use of b-blocker therapy\>=30 days prior to surgery
3. Undergoing non-cardiac surgery with an expected length of stay ≥ 48 hours for medical reasons
4. Informed consent
5. Undergoing major vascular surgery (excluding carotid endarterectomy, dialysis shunt, and vein stripping) OR

Meet \>= 2of the following criteria:

1. Coronary artery disease
2. Congestive heart failure
3. Stroke or transient ischemic attack
4. Diabetes mellitus requiring oral hypoglycemic or insulin therapy
5. Preoperative renal insufficiency (creatinine clearance below 60 mL/min)
6. Peripheral vascular disease, as defined by any of the following: history of ischemic intermittent claudication or rest pain, history of revascularization procedure to legs, peripheral arterial obstruction of \>= 50% luminal diameter
7. Age \>=70 years
8. Intermediate-risk surgical procedure: intra-peritoneal, intra-thoracic, carotid endarterectomy, major orthopedic (hip, knee, spine) surgery, radical prostatectomy, or head-and-neck surgery

Exclusion criteria: - if meets any of the following

1. Prior adverse reaction to clonidine or a-2 agonists
2. Current use of Clonidine or a-2 agonists
3. Current congestive heart failure
4. Only b-blocker taken by patient is sotalol
5. Left ventricular ejection fraction \<=40%
6. Systolic blood pressure \< = 90 mmHg
7. Concomitant life-threatening disease likely to limit life expectancy to \<=30 days.
8. Clinically significant aortic stenosis, defined as an aortic valve area \<=1.0 cm2 and/or peak trans-valvular pressure gradient \>= 25 mmHg
Longterm Immunogenicity of the Japanese Encephalitis Vaccine IC51

The study investigates the long term safety and immunogenicity of the Japanese Encephalitis vaccine IC51 up to month 60.


Eligibility Criteria:
Inclusion Criteria:

* Healthy subjects at least 18 years of age
* Written informed consent obtained prior to study entry
* Subjects correctly included and having completed clinical studies IC51-301 (NCT00604708) and IC51-302 (NCT00605085) with at least one vaccination

Exclusion Criteria:

* Inability or unwillingness to provide informed consent and to abide the requirements of the study
How Virtual Reality is Impacting Balance: An Examination of Postural Stability

There are several studies examining the effects of different sensory stimuli on balance in healthy young people. Our study will especially explain how the same environment will affect postural control, when projected into VR environment. In this way, we aim to contribute to the literature and virtual reality programs used in rehabilitation.

Thanks to the development of technology in recent years, virtual reality applications have started to be included in physiotherapy. Virtual reality is used in both clinical and academic studies for the purpose of training rather than evaluation. In the literature, it has been emphasized that traditional balance training does not have any superiority over virtual reality and virtual reality training can be used as a practical alternative in the long term (12,13). Furthermore, the feedback provided by virtual reality games is effective in the patient\&#39;s participation in the treatment. Different visual stimuli created using virtual reality can affect postural control in different ways (14). In addition, there is no study comparing the effect of real image and virtual reality image on postural control by transferring the current environment to virtual reality. The aim of this study is to reflect the real environment to virtual reality; To explain how postural control is affected by eyes closed, eyes open and in virtual reality. Two hypotheses were determined in this study.

H0: There is no significant difference between the real environment and three virtual environment on postural control in healhty subject.

H1: There is a significant difference between the real environment and three virtual environment on postural control in healthy subject.

Eligibility Criteria:
Inclusion Criteria:

* Being between the ages of 18-30
* The absence of any medical diagnosis
* Having visual acurity or corrected visual acurity
* Being volunteer

Exclusion Criteria:

* The presence of any medical diagnosis
* The presence of any neurologic symptoms
* The presence of any sensory problems
* The presence of any balance problems
* The presence of any vestibular problems
* Previous ortophedic surgery
* The use of an additional assistive device
Positioning of Surgical Patients With Sleep Apnea

The study aims to evaluate the effect of non-supine positioning in the treatment of surgical patients with obstructive sleep apnea. The hypothesis is that non-supine positioning will result in a decrease in acute hypoxic events, defined as the number of apneas/hypopneas per hour of sleep.

This is a prospective, randomized controlled trial that will comprise of two stages. Stage 1 is a pilot study of 30 patients at high risk or diagnosed with obstructive sleep apnea who are scheduled for routine surgery. These patients will be randomized 1:1:1 to standard of care (0 degree bed angle), 30 degree bed angle, or 60 degree bed angle. Acute hypoxic events will be analyzed pre and post-op in the randomly assigned bed position. PACU nurses will also be surveyed for patient-favored non-supine positioning (30 vs. 60 degrees). Stage 2 will be a larger, powered trial to evaluate the efficacy of just one bed angle (30 or 60 degrees) based on the Stage 1 results.

Eligibility Criteria:
Inclusion Criteria:

* Minimum 1 night postoperative hospital stay
* More than 18 and less than 80 years old
* Identified as high risk of OSA (SACS \> 15) or a history of OSA without CPAP treatment

Exclusion Criteria:

* Unwilling or unable to give informed consent
* Undergoing nasal, eye, head/neck surgery, intracranial or cardiac/thoracic surgery
* Currently undergoing treatment for sleep apnea including CPAP
* Requiring prolonged postoperative ventilation
* NYHA functional class III and IV
* Valvular heart disease, dilated cardiomyopathy, implanted cardiac pacemaker, or unstable angina
* Myocardial infarction or cardiac surgery within 3 months
* Chronic obstructive pulmonary disease, or asthma
* Presence of tracheostomy, facial, neck, or chest wall abnormalities
* Abdominal aortic aneurysm surgery, chemotherapy, or immunosuppressive therapy within 3 months
* Visiting preoperative clinic less than 3 days before surgery
* Requiring postoperative nasogastric tube