cyrilzakka/clinical-trials huggingface dataset:
Magnetic Resonance Elastography in Infants

MRI \& MRE in infants

The purpose of the present pilot study is to determine the feasibility of using MRI and MRE to evaluate the liver in infants with suspected liver disease.

Eligibility Criteria:
Inclusion Criteria:

* Infants \< 6 months of age
* Known liver disease based (liver enzymes, bilirubin, and/or GGT at least twice the upper limit of normal for age)
* Parental/LAR permission obtained

Exclusion Criteria:

* Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology
* Severe coagulopathy (INR \> 3 or platelets \<50,000)
Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery

The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing thyroidectomy
* Age 20-65
* American Society of Anesthesiologists physical status classification I or II

Exclusion Criteria:

* History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs
* History of drug \& alcohol abuse
* Psychiatric disorder
* Use of opioids within 24hrs
* Renal disease with decreased glomerular filtrate ratio
* Neuromuscular disease, Severe cardiac disease
Local Anesthetics for Pain Reduction Prior to IV Line Placement

The purpose of this study is to compare the pain level felt by patients when receiving placement of a peripheral intravenous catheter (IV line) following the administration of a local anesthetic. The local anesthetics tested will be lidocaine, buffered lidocaine, and bacteriostatic normal saline. Lidocaine is commonly used as a premedication for reducing the pain upon insertion of peripheral IV lines. However, due to its acidic nature, the lidocaine itself may cause pain upon administration. To help counter this discomfort, pharmacies can "buffer" the lidocaine using sodium bicarbonate, which increases the pH to a neutral value, resulting in less pain. Bacteriostatic normal saline has also been used for local anesthesia with peripheral IV placement, particularly in patients with a lidocaine allergy, as it contains benzyl alcohol which acts as a local anesthetic.

There are minimal reports from the literature that directly compare patient reported pain of all three agents to one another, although studies do exist that have compared buffered lidocaine versus lidocaine and buffered lidocaine versus bacteriostatic normal saline. To address this comparison gap, the following research questions need to be asked: which anesthetic agent is the superior premedication for reducing the amount of pain upon administration of the local anesthetic itself and for the pain associated with the peripheral insertion of the catheter? The hypothesis of the investigators is that there is not a significant difference in the degree of pain scales between the anesthetic agents to justify the pharmacoeconomic costs associated with compounding buffered lidocaine.

The primary outcome measured in this study will be the level of pain reported by the patient upon administration of the local anesthetic and upon insertion of the peripheral intravenous catheter. A secondary outcome includes a pharmacoeconomic analysis that will look specifically at the cost-savings of using one agent over the other and will take into account the daily time allocated to pharmacy technicians and pharmacists for compounding and verifying buffered lidocaine.


Eligibility Criteria:
Inclusion Criteria:

* Males or females \> 18 y.o.
* Ability to speak, read, an/or understand English
* Ability to communicate a level of pain via the specified pain scale
* A written order exists for an intravenous peripheral catheter insertion for the patient

Exclusion Criteria:

* Lidocaine allergy
* Buffered lidocaine allergy
* Benzyl alcohol allergy
* Non-English speaking
* Non-responsive or unable to understand or report pain score (ex. intubated in the ICU)
* Inability to place catheter
Kinematic- Versus Ligament-balanced Mechanical Alignment in TKA

A promising new approach in total knee arthroplasty (TKA) for severe osteoarthritis of the knee joint is the the kinematic aligned procedure (KA). This technique provides prosthesis-positioning based on natural and individual axes of movement.

Although first series have shown satisfying results, further verification by prospective studies and final meta-analyses will be required.

Thus, the kinematic alignment represents one of the few new developments in TKA.

Provided that patients are willing to participate in the study, patients data are collected preoperatively and during routine follow-up examinations and evaluated prospectively. Patients will receive either a conventionally mechanical aligned arthroplasty or a kinematical aligned TKA, according to a randomized procedure.

The kinematic alignment will be achieved by the use of custom-made cutting-blocks. Therefore, the patients will undergo a computed tomography of the whole leg on the affected side. This is mandatory in order to provide the individually produced cutting blocks.

In order to ensure comparability, patients are stratified regarding their age and gender before inclusion.

Outcome will be measured by the use of standard scoring systems regarding function, pain and ROM (range of motion) three, six and 12 months after surgery.

This study is a monocentric, prospective, randomized and controlled open study.


Eligibility Criteria:
Inclusion Criteria:

- Severe osteoarthritis of the knee joint, intended for total knee arthroplasty

Exclusion Criteria:

- malalignment with varus of more than 5° or valgus malpositioning, joint instability
Neuraxial Versus Systemic Analgesia for Latent Phase Labor Effect on Rate of Operative Delivery

The purpose of this study in nulliparous women undergoing induction of labor is to determine whether initiation of neuraxial analgesia compared to systemic opioid analgesia early in labor (\< 4 cm cervical dilation)affects the cesarean delivery rate.

Women in early labor frequently request pain medication. Obstetricians may prescribe narcotics (administered as an intravenous (IV) or intramuscular (IM) injection). However, IV or IM narcotics provide incomplete pain relief and have maternal and fetal/neonatal side effects, e.g., maternal drowsiness, respiratory depression, nausea, vomiting, and neonatal respiratory depression. Other obstetricians allow their patients to request early neuraxial (spinal or epidural) analgesia. The results of several studies comparing patients who received epidural versus IV/IM narcotic labor analgesia (not specifically in early labor)suggest that initiation of early neuraxial analgesia may be associated with higher Cesarean delivery rates. It has been hypothesized that epidural/spinal local anesthetics may induce pelvic musculature relaxation leading to failure of fetal descent and rotation. However, early pain may be a marker for other factors that increase the risk of Cesarean delivery, e.g., large or malpositioned baby, or dysfunctional labor. Whether or not early neuraxial analgesia (particularly if narcotic based, which would not cause pelvic muscle paralysis) compared to IV/IM narcotics, adversely affects the outcome of labor has not been studied in a randomized, prospective fashion. The purpose of this study is to compare Cesarean and forcep delivery rates, and quality of pain relief, in first-time mothers undergoing induction of labor who receive neuraxial versus IV/IM analgesia for early labor (cervical dilation \< 4 cm).

Eligibility Criteria:
Inclusion Criteria:

* induction of labor
* nulliparity
* \>36 weeks gestation
* singleton
* vertex position
* cervical dilation \< 4 cm at first request for analgesia
* desires neuraxial analgesia

Exclusion Criteria:

* spontaneously laboring
* multiparity
* nonvertex presentation
* at or \>4cm at analgesia request
* chronic opioid therapy
* acute opioid therapy within 4 hours of analgesia request
* allergy to study drugs (hydromorphone, fentanyl, bupivacaine, lidocaine)
The Effect of North American Ginseng on Blood Pressure in Individuals With Hypertension

To determine the effect of North American ginseng on blood pressure in individuals with hypertension.

Ginseng lacks proper clinical scrutiny for its effect on blood pressure (BP), in spite of observational evidence linking its intake to hypertension. This should be addressed considering the potential overlap between the prevalence of ginseng use and hypertension.

We undertook a single centre, randomized, controlled, double-blinded, crossover trial to determine the effect of North American ginseng (NAG) on 24-hour BP and renal function. After a 4-week placebo run-in, we randomly assigned participants to NAG or placebo treatment for 12-weeks at a dose of 3g/day. This was followed by an 8-week washout, and a subsequent 12-week period in which the opposite treatment was consumed. At run-in, and at weeks 0 and 12 of each treatment period, participants were fitted with an ambulatory BP monitor to assess 24-hour BP and serum cystatin C was measured.

Eligibility Criteria:
Inclusion Criteria:

* aged 18 to 85 years
* hypertension as defined by the use of antihypertensive drugs or a seated systolic blood pressure greater than or equal to 140 mm Hg or a diastolic BP greater than or equal to 90 mm Hg at each of 3 pre-study visits.

Exclusion Criteria:

* secondary hypertension
* diabetes
* kidney
* liver disease
* unstable angina
* ginseng use for two months prior to or during the study
* any changes in the type or dose of antihypertensive drugs one month prior to or during the study
Diagnosis of Pulmonary Embolism by Doppler Signals

The LDS may contain information of significant diagnostic and physiological value regarding the pulmonary parenchyma and vasculature, as well as the cardio- vascular system in general. In pilot clinical studies of patients with acute decompensated heart failure (ADHF) as well as patients with Pulmonary Hypertension, LDS signals patterns unique to these conditions were identified. We believe that these newly discovered ultrasound signals might provide a non-invasive radiation-free means to diagnose and monitor patients with Pulmonary Embolism.

The purpose of this study is to assess the utility of noninvasive assessment of lung Doppler signals performed via transthoracic parametric Doppler. The objective of the study is to evaluate the lung Doppler signals (LDS) in patients diagnosed with acute PE, in order to determine the potential assessment value of this non-invasive method in this potentially life threatening condition.


Eligibility Criteria:
Inclusion Criteria:

* Confirmed diagnosis of acute PE on CTA

Exclusion Criteria:

* Pregnant women
* Inability to consent
* Patients with severe chest wall deformity
* Previously diagnosed PE
* Pneumonia
* Pulmonary edema
* Pneumothorax
* Severe COPD (gold class III, IV)
* Hemodynamically unstable patients
The Effect of Exercise Training on Gait and Quality of Life in Parkinson's Disease

The project aims to evaluate the effects of 24 weeks of treadmill training (TT), with and without a strengthening component, on functional mobility, gait and quality of life in patients with Parkinson's disease (PD). The rationale for a study of this type stems from the hypothesis that treadmill training may act as an external "pacemaker" and enhance some properties of gait. There is a need for larger scale randomized controlled trials comparing the effects of treadmill training to control groups that receive similar amounts of attention. To date, no study has combined TT and muscle strengthening, likely the optimal form of therapy. A kinesiologist supervises the training, 3 times per week, for a total of 72 one-hour exercise sessions. It is hypothesized that at the end of 6 months, treadmill training will considerably improve walking parameters and the well being of people with PD.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of idiopathic Parkinson's disease
* Stage of II or less on Hoehn and Yahr scale

Exclusion Criteria:

* Having musculoskeletal impairments or having excessive pain in any joint that could limit participation in exercise program
* Dementia (MMSE\<24)
* Having balance problems
* Live beyond 45 minutes from Laval University
Causes of Non-invasive Fungal Sinusitis as Presented in Sohag University Hospital

in this study, the investigators will collect data from patients with non-invasive fungal sinusitis to know what causes it

In this study, the investigators will try to know the epidemiology of noninvasive fungal sinusitis, especially in recurrent cases This study will be carried out at sohag university hospital. Retrospective study Study period: 5 years (from August 2016 to August 2021. )

Eligibility Criteria:
Inclusion Criteria:

* Patients with Acute fungal sinusitis.
* Patients with chronic granulomatous sinusitis.
* Patients with sinus mycetomas.

Exclusion Criteria:

* Immunocompromised patients.
* invasive fungal sinusitis.
Metabolic Modulation as Treatment in Acute Heart Failure

The primary objective of this study is to evaluate whether metabolic modulation improves hemodynamics and outcome in acute heart failure

Acute heart failure is a serious disease that despite modern therapies carries a high mortality. Inotropic drugs improve patient status but yield a higher risk of death. Previous studies have shown that myocardial contractility improves when glucose fermentation is up regulated and decreases when Free Fatty Acids are high. In a placebo-controlled design we wish to shift myocardial substrate metabolism towards increased glucose uptake and utilization and measure hemodynamics and biochemical markers of metabolism and prognosis.

Eligibility Criteria:
Inclusion Criteria:

* Acute heart failure
* NYHA class III - IV.
* ejection fraction \<35

Exclusion Criteria:

* Age \<18 år or \>85 år,
* allergy
* renal failure
* recently developed brady- or tachy-arrythmias
* Serious infection
* Heart failure due to restrictive or hypertrophic cardiomyopathy or stenotic valvular heart disease
* Recent Myocardial infarction (\<6 Weeks)
* Pulmonary Wedge pressure \>30 mm Hg
* diabetes mellitus treated with insulin
* peptic ulcer
* pregnancy
Levetiracetam in the Treatment of Neuroleptic-induced Tardive Dyskinesia

An 8-week study to examine safety and efficacy of levetiracetam in patients with neuroleptic-induced tardive dyskinesia


Eligibility Criteria:
Inclusion Criteria:

* Subjects between ages 18 and 80 years
* Subjects must have a diagnosis of stable axis I psychiatric disorder at least 6 months prior to screening
* Subjects must have a stable neuroleptic-induced tardive dyskinesia at least 1 month prior to screening and meet tardive dyskinesia severity criteria
* Subjects must have used antipsychotics for at least 6 cumulative months, and, be on a stable dose for 1 month prior to screening

Exclusion Criteria:

* Presence of any axis II condition within 6 months prior to screening
* Huntington´s disease, idiopathic dystonia, Wilson´s disease, Sydenham´s chorea, thyroid dysfunction, spontaneous dyskinesia
* Start of drugs-other than neuroleptics- that can cause dyskinesia
* Presence of additional major disease such as cardiac, renal or hepatic dysfunction or terminal illness
The Children and Adolescents Nasopharyngeal Carcinoma Survivor Study

The Children and Adolescents Nasopharyngeal Carcinoma Survivor Study will investigate the long-term effects of nasopharyngeal carcinoma (NPC) and its associated therapies. A prospective and retrospective cohort study will be conducted through a multi-institutional collaboration. This project will study children and adolescents exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

The study will focus on the following objectives:

* Characterize survivors' health with respect to disease- and treatment-related factors.
* Investigate the consequences of various intensities of exposure to chemotherapy and/or radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc...).
* Compare the mortality experience of survivors with the general population.
* Characterize the health-related behaviors, patterns of medical care, and medical follow-up needs of survivors.
* Describe patterns of familial aggregation of cancer, including known (and variations of) cancer family syndromes.
* Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate with health outcomes and use for future research.

Eligibility Criteria:
Inclusion Criteria:

* Patients or their siblings must be informed of the investigational nature of this study and give written informed consent.

  * Patients with histologically confirmed non-keratinizing nasopharyngeal carcinoma (including differentiated type and undifferentiated type, WHO II or III) before age 21 years at one of participating centers.

Exclusion Criteria:

* Already involved in other blind clinical trial.
* The information of tumour response evaluation and survival data cannot be obtained.
Documentation of Cardiac Arrhythmias After Open Heart Surgery

This study aims at recording cardiac arrhythmias in patients after open heart surgery. The arrhythmias will be monitored during the entire first postoperative period, till six weeks after surgery.

Approximately 30-50% of patients after cardiac surgery develop cardiac arrhythmias, most often atrial, and most frequently atrial fibrillation (AF).

Various risk factors, inter alia, the type of surgery itself are risk factors. The major additional risk factors for postoperative atrial fibrillation are: age, valvular involvement, length of cardiopulmonary bypass and cross-clamp times.

Postoperative atrial fibrillation is associated with increased length of stay, higher morbidity and mortality including stroke.

Documentation of postopertive atrial fibrillation is well gathered during the postopertive length of stay, but scarce information exists regarding the development and occurence of atrial arrhythmias after the patient's discharge.

Additionally, the various management protocols which exists with regard to postoperative atrial fibrillation, rely on continuous treatment of the patients with amiodarone or various other anti-arrhythmic agents for the initial postoperative period, and the initial first month after discharge.

So far there is not an unambiguous recommendation regarding the duration of treatment required with amiodarone after releasing the patient.

The aim of this study is to document and record cardiac arrhythmias in patients after open-heart surgery within the time window since the release from hospital and up to six weeks after surgery.

Results of the study will allow us to fully characterize postoperative arrhythmias and their risk factors.

Eligibility Criteria:
Inclusion Criteria:

1. 18 years or older.
2. Patients after open-heart surgery (any type of surgery).

Exclusion Criteria:

1. Patients with internal pacemaker.
2. patients with known basic arrhythmia (pre-surgery) or patients who are discharged with some arrhythmias.
3. Patients with low response which it is expected that there will not be able to use the monitoring device
Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis

This study will evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease.

The primary purpose of this study is to evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease. This study will also investigate the link between oral and systemic inflammation in patients diagnosed with depression and periodontal disease. Researcher will collect gingival crevicular fluid, plaque, tissue and blood serum samples to evaluate the link between these two diseases. The collection of gingival crevicular fluid, plaque and blood serum is relatively non-invasive, elicits minimal discomfort and does not require use of any anesthesia. The soft tissue sample will be collected as part of an otherwise planned periodontal surgical procedure under local anesthesia. In periodontal therapy (surgical procedures i.e. gum surgery, tooth extraction and or dental implant surgery) there is enough availability of remnant tissue for the collection of samples, which is otherwise discarded.

Eligibility Criteria:
Inclusion Criteria:

* At least 18 years old
* Must be a patient of the UAB Dental School
* Able to read and understand informed consent document
* Good general health as evidenced by medical history
* Minimum of 18 teeth, excluding third molars
* Having moderate to severe periodontal disease according to AAP definition (teeth ≥5 mm PD and ≥3 mm CAL)
* Having \>30 percent bleeding sites upon probing
* Patients taking depression medication with chronic periodontitis
* Patients without depression with chronic periodontitis
* Patients who have not had a dental cleaning in the past 3 months prior to procedure
* Patients scheduled for surgical procedures (i.e. gum surgery, tooth extraction, or dental implants)

Exclusion Criteria:

* Non-English speaking
* Less than 18 years old
* Smokers/tobacco users (\>10 cigarettes/day)
* Any dental condition that requires immediate treatment, such as emergency care
* Chronic use (≥3 times/week) of anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs, steroids). Low-dose aspirin (less than 325 mg daily)
* Immunocompromised subjects
* Any medical history or any concomitant medication that might affect the assessment of the study treatment or periodontal tissues, such as uncontrolled diabetes, nifedipine, phenytoin (Dilantin), subjects with arthritis and morbidly obese (BMI ≥ 40)