cyrilzakka/clinical-trials huggingface dataset:
Burden of Urinary Incontinence in Home Care Patients in the State of Geneva

Urinary incontinence (UI) is a frequent problem in community-dwelling older adults and has a huge burden on health complications and healthcare costs. Although effective treatments exist, UI is frequently neglected resulting in unmet needs for continence treatment and potential negative health outcomes. The impact of UI in older patients receiving home care services has not been extensively explored. In a recent study we observed that UI was identified in 46% of 699 patients followed by the "Fondation des Services d'Aide et de Soins à Domicile" in Geneva but the impact of UI on outcome such as institutionalization, hospitalization or death is unknown.


Eligibility Criteria:
Inclusion Criteria:

* Between July 2004 and December 2004
* 699 adults patients followed by the "Fondation des Services d'Aide et de Soins à Domicile" in Geneva (two region in the state of Geneva: Meyrin and St-Jean)
Recovery - a Collaborative Project

In Norway, official guidelines and policies state that recovery oriented services in the field of mental health and substance abuse services is a desirable goal.

This collaborative research project aims to provide in-depth knowledge of how recovery oriented practices and collaboration in the mental health and substance abuse services in the municipality of New Drammen develop over a three-year period.

Using qualitative methods, the main aim of the study is to explore what recovery orientation of services in mental health and substance abuse presupposes and involves related to roles, collaboration and knowledge.

To explore these issues, service users will be interviewed together with their primary mental health professional.

The study will also apply observational fieldwork in order to observe recovery oriented practices between service users and professionals and between professionals.

An advisory group consisting of people with background as service users, mental health clinicians and service leaders will contribute throughout the project.

.


Eligibility Criteria:
1. Adults who have received community mental health and / or substance abuse services for the past year or longer, due to moderate or severe mental health and / or substance abuse problems.

   Inclusion Criteria:
   * receives community mental health services due to mental health and /or substance abuse related problems
   * Above 18 years old

   Exclusion Criteria:
   * Under the age of 18
2. Mental health workers in the municipality, working in mental health and substance abuse services
Physical Performance Measures for Manual Wheelchair Users

The project is intended to modify the Functional Independence Measure (FIM) for manual wheelchair users. It will determine if the new measure is a better measure of community independence for manual wheelchair users than the FIM. During the Phase 1 of the study it will then use this new measure to determine whether a home exercise program increases functional independence in wheelchair users. In Phases II and III of the study 120 manual wheelchair users will participate to test and validate the new measure and to test the effectiveness of therapeutic exercise. Subjects will range in age from 20 to 79 yrs. and have a variety of disabilities.


Eligibility Criteria:
Wheelchair users
BASKA Mask Versus Endo Tracheal Tube in Gynecological Laparoscopic Surgery

The BASKA mask (Logikal Health Products PTY Ltd., Morisset, NSW, Australia) is a novel supraglottic airway device. It has many of the features of other supraglottic airways, with a number of innovations. These include; A non-inflatable cuff, that it is continuous with the central channel of the device. As the pressure increases with positive pressure ventilation, the cuff itself is 'inflated', this may improve the seal, reduce leak, and make ventilation more efficient.

The BASKA mask incorporates an inlet that fits into the upper esophagus, and the dorsal surface of the cuff is moulded to direct any oropharyngeal contents away from the glottis and towards the side channels to which suction can be attached to facilitate aspiration of this space (Fig.1c). These features may reduce the risk of pulmonary aspiration of secretions or gastric contents that accumulate in the supraglottic area.

Compared with previous versions, these modifications have made BASKA mask airway a fairly safe and effective airway device in low-risk patients undergoing gynecologic laparoscopic surgeries

Eligibility Criteria:
Inclusion Criteria:

Sex: Female patients scheduled for elective gynecological laparoscopic surgery.

* Age: 18-60 years.
* BMI\< 30kg/m2.
* ASA physical status: I-II.
* Operation: gynecological laparoscopic surgery under general anesthesia of an anticipated duration\<1h.

Exclusion Criteria:

* Patient refusal.
* History of cardiac disease, psychological disorders, respiratory diseases including asthma, renal or hepatic failure.
* Patients who have high risk of regurgitation or aspiration based on history of gastro esophageal reflux, hiatus hernia, diabetes and gross obesity.
* Neck pathology.
* Patients who predicted difficult airway (based on a history of difficult airway, mouth opening was less than 2.5 cm, inter-incisor distance \< 20 mm, cervical spine pathology, modified Mallampati class III/IV, or thyromental distance \< 65 mm).
* Allergy to any of the anesthetic agents used.
* The possibility of being pregnant.
* Heavy smoker.
* Preoperative sore throat.
Efficacy of Two Physiotherapy Intervention Methods Applied in Subjects in the Social-healthcare Setting With Nonspecific Neck Pain.

The overall objective of this study is to compare the effectiveness of two physiotherapy treatments, one based on the application of massage most current analgesic TENS compared to a second massage treatment based on more specific stretching techniques in subject in th social-health care setting with non-specific neck pain.

The subjects included in the sample will be evaluated according to the above-mentioned parameters by researchers trained and assigned for this purpose.

The data collection of the different variables will be carried out before and after the completion of the programs designed for the study. The programs designed for the experimental groups have a duration of 10 sessions, twice a week.

Eligibility Criteria:
Inclusion Criteria:

* Age range between 18-60 years.
* Cervical pain of non-specific origin or Cervicalgia type I and II according to the Quebec - Task Force on Spinal Disorders.
* Be willing to participate in the study and sign the informed consent form.
* Have at least one year of seniority in the company exercising the current professional activity within the team of socio-health personnel.

Exclusion Criteria:

* Cervicalgia with neurological involvement or caused by pathologies such as: inflammatory disease, neurological disease, rheumatic disease, severe osteoporosis, fracture, dislocation, vertebro-basilar insufficiency, neoplasia or infection.
* Spine surgery.
* Present metallic implants at the spinal column level.
* Have received physiotherapy or alternative treatment in the last 6 months before starting the study.
* To present any type of inconvenience to the application of electrotherapy (score ≥45 points in EAPP).
Asian Clinical Evaluation of an Investigational Contact Lens for Cosmetic Effect

The purpose of this study is to compare the cosmetic appearance of two different contact lenses on Asian eyes.

Participants will be asked to evaluate the cosmetic appearance of two different contact lenses worn contralaterally for 20 minutes. No vision or comfort variables will be assessed in this cosmetic appearance and lens fit non-dispensing study.

Eligibility Criteria:
Inclusion Criteria:

* Female between 18 and 30 years of age (inclusive).
* If under 21 years of age, subject must sign informed assent and have written consent of parent or guardian to participate.
* Sign written Informed Consent.
* Chinese, Japanese, or Korean descent.
* Brown eye color.
* Spherical equivalent refractive error of -0.50 diopter (D) and between (-1.50 to -2.50D), (-3.50 to -4.50D) and (-5.50 to -6.50D).
* Other protocol-defined inclusion criteria may apply.

Exclusion Criteria:

* Eye injury or surgery within twelve weeks prior to enrollment.
* Pre-existing ocular irritation that would preclude contact lens fitting.
* Currently enrolled in any clinical ophthalmic trial.
* Evidence of systemic or ocular abnormality, infection or disease which is likely to affect successful wear of contact lenses or use of accessory solutions as determined by the investigator.
* Any use of medications for which contact lens wear could be contraindicated as determined by the investigator.
* Other protocol-defined exclusion criteria may apply.
Effectiveness of a Health Education Programme for Prevention of Chronic Migraine: A Randomized Clinical Trial

Chronic migraine (CM) is a common and frequent disorder, which has a major impact on the quality of life of migraine sufferers, interfering with physical function, productivity at work, personal life and leisure, lifestyle and psychological well-being.

The use of a prophylactic drug treatment is recommended if headache is present more than 8 days per month. In addition, several studies have shown benefits of non-pharmacological interventions such as self-management strategies, manual therapy and exercise. However, no studies have been found that analyse the beneficial effect of a combination of a preventive drug treatment and a health education programme.

Thus, this project would offer a service of health education through a telerehabilitation programme for patients with chronic migraine under prophylactic drug treatment.

The aim of this study is to compare the combination of a prophylactic drug therapy and a health education programme in the preventive treatment of patients with chronic migraine.based on the hypothesis that a health education program for chronic migraine patients could decrease the number of migraine days.

Design:

A randomised, double-blind, controlled clinical trial will be conducted in two parallel groups, in which all patients with migraine chronic are receiving prophylactic drug treatment with Fremanezumab or Erenumab as prescribed by a physician. Moreover, patients in the experimental group will receive a health education programme and patients in the control group will receive a programme of general recommendations.

Intervention:

A 4-week baseline data collection period is included to record the frequency and intensity of migraine pain before starting the study.

The intervention will be carried out for 6 months with a follow-up at 1, 3 and 12 months.

Experimental group:

Patients will receive health education through video-tutorials that can be watched on the HEFORA platform. Each video-tutorial will contain the content of an educational session, including health information in the areas of pain education, migraine neurophysiology, relaxation techniques, sleep habits, eating habits, physical exercise, coping strategies and emotion management.

Control group:

Patients will receive video-tutorials with general recommendations though HEFORA platform.

Eligibility Criteria:
Inclusion Criteria:

* Age range 18-65 years.
* Patients diagnosed with CM following the ICHD-III criteria.
* Patients with migraine onset before the age of 50 years.
* Patients who have been diagnosed with chronic migraine for at least 1 year.

Exclusion Criteria:

* Women who are pregnant or breastfeeding.
* Women with menstrual migraine.
* Patients with severe or unstable psychiatric pathology that contraindicates the use of drug treatment.
* Allergic patients or those who show sensitivity to components of the drug treatment.
* Patients who refuse to sign the informed consent form or to participate in the study.
* Patients who decide not to continue in the study.
Bird Watching to Reduce Stress in University Students

The goal of this study is to learn if birdwatching can reduce stress in university students. It will also explore students\&#39; experiences with the intervention. The main questions it aims to answer are:

Does birdwatching reduce students\&#39; perceived stress levels? What are the experiences of students who participate in the birdwatching intervention? Why do some students drop out of the study? Researchers will compare a group of students who participate in birdwatching outings to a control group that does not receive the intervention to determine if birdwatching is effective in reducing stress.

Participants will:

Either participate in birdwatching outings or be in a control group with no intervention Complete a perceived stress scale (PSS-10) to measure their stress levels Take part in semi-structured interviews to discuss their experiences with the intervention or their reasons for dropping out of the study


Eligibility Criteria:
Inclusion Criteria:

* University students who meet the following inclusion criteria will be included in the study: being 18 years of age or older, being enrolled in any undergraduate program at the Universidad Industrial de Santander, having a score of 10 or higher on the Perceived Stress Scale (PSS-10), and having access to WhatsApp.

Exclusion Criteria:

* University students with a medical diagnosis of any mental illness under pharmacological or non-pharmacological treatment, with health conditions that prevent them from seeing, hearing, or moving, as well as students who have engaged in birdwatching in the last six months, will not be included.
Prediction of Delivery With Transperineal Ultrasound in Women With Prolonged Labour. Multicentre Study

Objectives

1. To assess if head-perineum distance and angle of progression measured with transperineal ultrasound by the obstetrician on call can predict delivery mode in primiparous women with prolonged first stage of labour.
2. To compare ultrasound assessments and clinical examinations.

Variables Digitally assessed cervical dilatation, fetal station and position Ultrasound measured fetal head-perineum distance. Ultrasound measured angle of progression Ultrasound assessed position

Possible confounders Ethnicity, maternal age, gestational age, BMI, induction of labour, augmentation, epidural analgesia, birth weight, head circumference

A two-dimensional ultrasound measurement will be obtained with the ultrasound device available in the delivery department. Fetal head descent is measured as the shortest distance between the outer bony limit of the fetal skull and the perineum with a curved transabdominal transducer placed transperineally between the labia in a transverse view (1).

The fetal descent will also be assessed measuring "angle of progression" as suggested by Barbera et al. The ultrasound transducer will be placed on the perineum in a mid-sagittal position between the labia below the pubic symphysis. The angle between a line through the symphysis and a line from the posterior part of the symphysis tangentially to the fetal skull contour will be measured (2)

A transabdominal scan will also be performed determining the fetal position as described previously. Positions ≥ 02.30 and ≤ 03.30 hours should be recorded as left occiput transverse and positions ≥ 08.30 and ≤ 09.30 as right occiput transverse. Positions \> 03.30 and \<08.30 should be recorded as occiput posterior and positions \> 09.30 and \< 02.30 as occiput anterior.(3).

Eligibility Criteria:
Inclusion Criteria:

* Primiparous women with single pregnancies and gestation age \> 37 weeks and prolonged first stage of labor

Exclusion Criteria:

* High risk pregnancies,
* premature deliveries,
* multiple pregnancies
Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence

This is a randomized, controlled trial with 50 veterans diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence. Veterans will be randomized to receive either zonisamide (400 mg) or placebo for 12 weeks in a double blind fashion. Randomization will be done using 3:1 ratio and will be performed by our research pharmacy using a random assignment in blocks of 4- 3 will be assigned to active medication and 1 to placebo. Medication will be titrated over a 6 week titration phase followed by a 6 week treatment phase. All veterans will receive E-CPT-C therapy for the 12 weeks of treatment; E-CPT-C will be provided by trained and qualified clinicians with extensive experience providing E-CPT-C. Veterans will be recruited primarily through advertisement, but also through the clinical facilities at the VA and from other collaborators.


Eligibility Criteria:
Inclusion Criteria:

* Current alcohol dependence, as determined by a structured clinical interview (Structured Clinical Interview for DSM-IV Axis I Disorders) (SCID)
* Current PTSD as determined by a structured clinical interview (SCID)
* Veterans with current alcohol dependence, with at least one recent episode of heavy drinking over the past 14 days.
* Medically and neurologically healthy on the basis of history, physical examination, EKG, screening laboratories
* For women, negative pregnancy test and use of acceptable method of contraception

Exclusion Criteria:

* Females who are pregnant or lactating.
* Veterans with a current unstable medical condition such as neurological, cardiovascular, endocrine, renal, liver, or thyroid pathology, which in the opinion of the physician would preclude the subject from fully cooperating or be of potential harm during the course of the study
* Veterans who meet current SCID criteria for a major Axis I diagnosis (Bipolar Disorders, Schizophrenia and Schizophrenia-type Disorders).
* History of substance dependence (other than alcohol, tobacco or cannabis) by DSM-IV criteria in the last 90 days.
* Veterans taking mood stabilizers and antipsychotic medications for specific psychiatric disorders.
* Veterans with a history of allergy to zonisamide.
* Veterans already receiving CPT.
Yoga/Pranayama for Posttraumatic Stress Disorder

This study aims to investigate the effect of a pranayama focused yoga intervention on post-traumatic symptom severity in patients with post-traumatic stress disorder undergoing standard psychotherapy/ trauma-focused cognitive-behavioral therapy (TF-CBT). Therefore, short pranayama sessions of 5-10 minutes will be provided to the patients directly at the begin of each of standard TF-CBT unit, while the control group will get standard TF-CBT alone. It should further be investigated, whether pranayama can enhance the affective tolerance of patients with post-traumatic stress disorder towards the used exposure techniques of TF-CBT.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed PTSD according to ICD-10
* PCL-5 Score of at least 33 points
* Undergoing outpatient CBT
* Physical and mental ability to perform Pranayama

Exclusion Criteria:

* Severe comorbid mental or somatic disease that did not allow the patient to perform Pranayama
* Pregnancy
* Regular practice of Yoga or Pilates in the last 12 months
Eligibility Screening for National Institute of Dental and Craniofacial Research Studies

This screening protocol is designed to evaluate patients for participation in clinical studies in the Gene Therapy and Therapeutics Branch (GTTB) of the National Institute of Dental and Craniofacial Research. To participate, patients must meet the specific requirements of at least one of the available research studies; this protocol serves as a first step for admitting patients to an appropriate program.

People with diagnosed or undiagnosed conditions may participate in this screening protocol. They will undergo procedures that may include questionnaires, a physical examination, routine laboratory tests, and diagnostic imaging or radiological studies. Eligibility screening will be limited to three visits within 12 months of entry into the protocol. If an appropriate study is not found by the end of this time, the candidate's participation in the screening program will terminate. No experimental treatments are offered under the screening protocol.

Patients who are found eligible for a current GTTB study will be notified of their options and invited to enroll.

This protocol is designed to screen patients with either diagnosed or undiagnosed conditions, and provides for determining eligibility for approved protocols within the Gene Therapy and Therapeutics Branch (GTTB), National Institute of Dental and Craniofacial Research. The purpose of the protocol is to allow evaluation of patients who do not meet the requirements for other screening protocols, such as the screening protocol for Sjogren's syndrome patients.

Each subject will be evaluated to determine whether they are suitable candidates for inclusion in any protocols in the GTTB. The screening evaluation will include past and current medical history, and an appropriate physical examination. Further routine diagnostic tests may also be performed to determine eligibility for approved studies. The tests and procedures are of minimal risk. When the screening has been completed, subjects will be informed of the options available at the time for participation in available, approved research protocols.

Eligibility Criteria:
INCLUSION CRITERIA:

All patients who may be eligible for other currently approved protocols.

Inclusion and exclusion criteria will vary according to the protocol(s) for which the patient is being screened.

Patients may be eligible if they have rare, unusual, interesting or unknown conditions that require diagnosis.