cyrilzakka/clinical-trials huggingface dataset:
Peer Support Group for Adolescent and Young Adult (AYA) Allogeneic Stem Cell Transplant Recipients

Allogeneic Haemopoietic Stem Cell Transplant (Allo-HSCT) is a potentially curative option for patients with both malignant and non-malignant hematological disorders. There appears to be unique experiences that adolescents and young adults (AYA) face when undergoing transplant. There is literature to suggest that peer support for young adults is associated with improvements in mental health including greater happiness, self-esteem and effective coping, as well as reductions in depression, loneliness and anxiety.

Our primary objective is to determine the feasibility and acceptability of an AYA peer support program for patients undergoing Allo-HSCT. Our secondary objective is to explore the impact of the AYA peer support program on sense of support/connectivity, anxiety, and depression.


Eligibility Criteria:
Inclusion Criteria:

* 18-39 years of age
* \>3 months post Allo-HSCT
* any malignant /non-malignant indication for Allo-HSCT

Exclusion Criteria:

- Non-English speaking
A Study of Predictors of the Effectiveness of Pegylated Interferon in a Cohort of Participants With Hepatitis C

This prospective observational study will investigate predictive values of virological response in pegylated interferon alfa-2a (Pegasys)/ribavirin (Copegus) treatment-naive participants with chronic hepatitis C. Participants will be treated with pegylated interferon alfa-2a and ribavirin as prescribed by the physician. Data will be collected for a maximum of 96 weeks.


Eligibility Criteria:
Inclusion Criteria:

- Diagnosis of chronic hepatitis C infection

Exclusion Criteria:

* Co-infection with human immunodeficiency virus (HIV) and/or hepatitis B
* Participants previously treated with pegylated interferon alfa-2a/ribavirin
* Participation in another clinical study within 30 days prior to study start of ML25544
Recurrent Neovascular Age-related Macular Degeneration After Therapy Suspension

The purpose of this study is to investigate prospectively the recurrence rate of active macular neovascularization (MNV) and the visual outcome in patients with nAMD previously on a Treat and Extend regimen where treatment has been discontinued due to disease stability.

All study subjects had nAMD and were treated at diagnosis with three monthly aflibercept injections and then subsequently followed in a treat and extend regimen with extensions by two weeks if no signs of disease activity were seen. Hemorrhage, intraretinal macular edema or subretinal fluid were considered signs of disease activity. Patients reaching 12-week intervals without any evidence of disease activity on three consecutive visits, a BCVA between 35-88 letters (Snellen 20/200- 20/20) and a near vision of at least 24 points were eligible for study inclusion.

If there were signs of recurrent disease activity during the follow-up, study participation was concluded at that point and intravitreal therapy was resumed. Between scheduled visits patients were encouraged to monitor their vision at home using monocular visual assessments and were advised to return earlier than planned if symptoms of visual deterioration or metamorphopsia occurred. At baseline and at every follow-up visit all patients had a full dilated ophthalmic examination. Optical coherence tomography (OCT) images were obtained by using the Zeiss Cirrus OCT instrument (Carl Zeiss Meditec, Inc.,Dublin, Ca). A pigment epithelial detachment (PED) was identified as an elevation of the RPE band and included both serous and fibrovascular PED. Near vision was tested at 40cm with the addition of +3 dioptres to the BCVA refraction. For near vision assessment we used the LIX adult A chart (Ortho-KM, Lund, Sweden) graded in typographical points, the largest text being 24 points and the smallest 4 points.

Eligibility Criteria:
Inclusion Criteria:

* Patients with inactive neovascular AMD reaching 12-week intervals in a treat and extend regimen without any evidence of disease activity on three consecutive visits.
* BCVA between 35-88 letters (Snellen 20/200- 20/20)
* Near vision of at least 24 points

Exclusion Criteria:

• Active neovascular AMD
Study of Tumor Samples in Patients Undergoing Radiation Therapy or Surgery For Primary Melanoma of the Eye

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This clinical trial is studying tumor samples in patients undergoing surgery or radiation therapy for primary melanoma of the eye.

OBJECTIVES:

Primary

* To establish the feasibility of using fine needle aspiration (FNA) and FISH to determine tumor genotype in patients with primary uveal melanoma.

Secondary

* To characterize ophthalmic complication rate of FNA for FISH analysis in patients undergoing plaque radiotherapy.
* To estimate disease-free survival in patients with and without tumor monosomy 3 and/or 8q amplification.
* To explore the relationship between tumor monosomy 3 and 8q amplification and plasma levels of tumor immune escape and invasion biomarkers (e.g., circulating granulysin, beta2-microglobulin, autotoxin, lysophosphatidic acid, matrix metalloproteinase-7, tissue inhibitor of matrix metalloproteinase, and soluble E- cadherin).
* To explore the psychological impact of prognostication in uveal melanoma.

OUTLINE: Patients undergo plaque radiotherapy, enucleation, or tumor resection based upon standard of care guidelines.

Trans-scleral fine needle aspiration (FNA) is performed at the time of plaque radiotherapy and ex vivo FNA is performed on enucleation and tumor resection specimens. Tissue samples are analyzed by fluorescence in situ hybridization (FISH). Blood samples are also collected for further analysis.

After completion of study therapy, patients are followed up periodically.

Eligibility Criteria:
Inclusion Criteria

* Patients must have a clinical diagnosis of melanoma of the iris, ciliary body and/or choroids
* Patients must have had a hepatic ultrasound and/or other suitable imaging studies to eliminate metastatic disease
* Patients must not have received any local or systemic therapy for uveal melanoma
* All patients must be informed of the investigational nature of this study and must provide written informed consent in accordance with institutional and federal guidelines. A copy of the informed consent document signed by the patient must be given to the patient
* Patients must have the following pretreatment laboratory findings:

  * Bilirubin (total) \</= 1.5 ml/dl
  * AST \</= 2 x normal
  * ALT \</= 2 x normal
  * Alkaline phosphatase \</= 2 x normal

Exclusion Criteria

* Patients with metastasis
* Patients under the age of 18
Effects of Virtual Reality Based Rehabilitation in Acute Stroke Patients in an Inpatient Rehab Setting

To evaluate the effects of virtual reality-based rehabilitation (Neofect Glove) for newly diagnosed cognitively intact adult dominant hemisphere stroke patients with paresis of their hand in supplementation with conventional occupational therapy to assess whether it improves motor function and speed recovery during inpatient rehabilitation versus conventional occupational therapy alone. Also, what impact does this have on quality of life.

The American Stroke Association states that stroke is 5th leading cause of death in the United States and one of the leading causes of disability and loss of motor function. Approximately 80% of stroke survivors have upper extremity limitations where the distal upper extremity motor function is severely affected and is the last body part to recover. Restoration of arm function is essential to regaining activities of daily living (ADL) such as holding objects like utensils, turning a doorknob, writing or telephone use. Literature search shows that intensive and repetitive training may be necessary to modify neural organization and recover functional motor skills. Along with traditional rehabilitation methods, virtual reality (VR) based rehabilitation has emerged in recent years. VR-based rehabilitation is more intensive, of longer duration and more repetitive. Using VR rehabilitation, repetitive dull exercises can turn into a more challenging and motivating tasks such as games. Moreover, VR-based rehabilitation can provide a quantitative measure of the rehabilitation progress.

The investigators propose a study comparing conventional occupational services versus virtual reality-based rehabilitation intervention for participants during acute phase of stroke in the inpatient rehabilitation setting. The investigators hypothesize that by using VRA, will see a significant increase in the overall motor function, shorter hospital course and improved quality of life for the participants.

Eligibility Criteria:
Inclusion Criteria

* Minimum age of 18 years' old
* Unilateral upper extremity functional deficits after stroke
* First ever clinical diagnosis of stroke in the dominant hemisphere
* Diagnosis of ischemic or hemorrhagic stroke with unilateral paresis of dominant hand

Exclusion Criteria:

* Age less than 18 years' old
* Cognitive impairment resulting in inability to participate
* Severe aphasia resulting in inability to communicate to give consent or participate.
The Use of Gastrografin in Chronic Radiation Enteropathy With Small Bowel Obstruction

Chronic radiation enteropathy (CRE) is a major issue for long-term cancer survivors. The aim of this study was to clarify the diagnostic and therapeutic effect of the Gastrografin (GG) challenge for patients with CRE induced small bowel obstruction SBO.


Eligibility Criteria:
Inclusion Criteria:

* with a first diagnosis of CRE combined with SBO and ASBO that was determined by clinical history, computed tomography (CT) manifestation, and conﬁrmed by intraoperative and histologic ﬁndings.
* radiation therapy completed at least 6 months before enrolment.

Exclusion Criteria:

* a colostomy or ileostomy;
* large bowel obstruction;
* with a known history of either allergy or hypersensitivity to iodinated contrast agents;
* with signs of strangulation;
* metastatic disease;
* obstruction within 4 weeks after a recent operation or serious comorbidity.
Can a Digital Education Program in Radiographic Imaging Technique for Dental Professionals Improve Image Quality?

The goal of this clinical trial is to learn if a digital education program designed for dental professionals can lead to radiographic examinations of better quality. The main questions it aims to answer are:

Does the digital education program lead to more radiographic examinations of good quality? Does the digital education program lead to better theoretical and practical understanding regarding image quality among dental professionals?

Researchers will compare answers from a theoretical test and image quality in radiographic examinations between participants with respectively without access to the digital education program.

Participants will:

* have access to the digital education program for three months
* after three months all study participants are invited to answer a theoretical test

The present study aims to evaluate a digital education programs effect on image quality in intraoral radiographic examinations performed by dental professionals. The present study is part of an on-going cross sectional descriptive project where dental professionals employed in general dental care in the county of Västerbotten, Sweden constitute the study population. The purpose of the project is to gain a broader understanding of a digital education programs impact on the theoretical and practical competencies among dental professionals regarding intraoral dental radiographic examinations.

Approximately 80 dental professionals have provided written informed consent regarding study participation. In the present study, approximately 40 participants will for three months be offered the intervention and join a digital education program. Approximately 40 participants will during the same period not be offered the intervention and constitute the control group. Effects on practical competencies between groups will be evaluated when analyzing image quality of intraoral radiographic examinations. Effects on theoretical competencies between groups will be analyzed with a theoretical test.

Cluster randomization of dental clinics will be made for study included participants to either intervention group or control group. Recruitment of study participants will end in August 2024.

The investigators hypothesize that the digital education program will improve the theoretical competence and radiographic image quality in intraoral radiographic examinations.

Eligibility Criteria:
Inclusion Criteria:

• Dental professionals performing radiographic examinations employed in general dentistry in the County Council of Västerbotten, Sweden

Exclusion Criteria:

• Dental professionals not performing radiographic examinations
Transcutaneous Electrical Nerve Stimulation After Total Hip Arthroplasty

Transcutaneous electrical nerve stimulation (TENS) is characterized by the application of an electric pulsed current through electrodes positioned on the skin. It can be an alternative for pain management after surgery for total hip arthroplasty (THA), since it is a safe and cost-effective therapeutic tool, allowing the patient to move early due to pain relief. Therefore, the study aims to evaluate the acute effects of TENS associated with standard physical therapy compared with standard physical therapy on the intensity of pain, hip range of motion and morphine consumption in the rehabilitation of patients after THA.

The study included patients who underwent THA surgery in the Hospital de Clínicas de Porto Alegre (HCPA) and met the study eligibility criteria. The sample was randomly divided into experimental group, which received conventional physical therapy associated with the application of TENS, and control group, which held only conventional physical therapy, both on the first day after the surgery. The pain level, the range of motion of the operated hip and the administration of morphine. The experimental group received TENS application held by four self-adhesive electrodes size 5x9cm positioned about five centimeters from the edges of the surgical scar. TENS was applied in conventional mode, emitting a pulsed biphasic, symmetrical rectangular wave with frequency of 100 Hz and pulse duration of 100 µs, for 30 minutes. The intensity was set according to the tolerance of the patient and was gradually increased during the application. The device used was the Neurodyn II model, by Ibramed. Subsequently, the conventional physical therapy was performed. The patients realized active exercises of plantar flexion and dorsal flexion of the ankles, flexion and extension of the knees and adduction and abduction of the hips, in both lower limbs. All exercises were performed with the patient in the supine position in the bed, in one serie of 10 repetitions. Control group received only conventional therapy consisting of the exercises in both lower limbs, identical to those performed in the experimental group.

Eligibility Criteria:
Inclusion Criteria:

* patients who underwent THA surgery due to primary or secondary coxarthrosis; both sexes; age between 40 and 90 years.

Exclusion Criteria:

* patients who refused to participate of the study; THA indication for fractures and bone tumors; THA review surgery; postoperative infection; congenital anatomical alterations; neurological disorders; lack of understanding of commands; sensitivity alterations in the lower limbs; decompensated heart disease or cardiac pacemaker use.
Pentoxifylline and Endometriosis

To prove efficacy of an immunomodulator called pentoxifylline in the treatment of endometriosis in infertile patients undergoing laparoscopy surgery


Eligibility Criteria:
Inclusion Criteria:

* Infertile patients having early endometriosis as the only factor of their infertility

Exclusion Criteria:

* Previous treatment for endometriosis or patients having pelvic disorders in addition to endometriosis
Exploring the Effectiveness of Interventions on Menstrual Hygiene Awareness in Slum Communities of Karachi, A Quasi- Experimental Analysis

Proper menstrual hygiene knowledge and practices are crucial among women. People of urban slum's areas have no or less knowledge and practices of Menstruation hygiene due to low socio-economic status. This study helps in Improving menstrual hygiene knowledge and practices and can empower individuals to manage their periods with dignity and comfort. This study also contributes in creating a more open and supportive environment for menstruation by addressing stigma and misconception. The study also helps in reducing the risk of reproductive tract infections.


Eligibility Criteria:
Inclusion Criteria:

* Woman age in between 15-45years of age
* Those who used reusable items for menstruations
* Those who are willing to participate voluntarily will be included in the study

Exclusion Criteria:

* Participants who are suffering from any serious medical condition.
* live in other than slums area of Karachi will be excluded from the study.
An Observational Study of GP Verbal Reminders Upon Cervical Screening

Cervical cancer screening is offered to all women in the United Kingdom (UK) between the ages of 24.5 and 64 years of age. The majority of screening is performed in primary care and the rate remains stubbornly below 80%, despite an automated national invitation system. This study is designed to assess the effectiveness of a physician invitation during a telephone or face-to-face primary care appointment upon non responders of automated invitations, to increase the uptake of cervical screening.

It is estimated that between 800 and 2,000 deaths a year are now prevented due to the effectiveness of the UK's national cervical screening programme and mortality rates have dropped by over 75% since the 1970s. These statistics corroborate the importance of the screening programme in reducing mortality from cervical cancer. Cervical screening rates in the UK remains stubbornly below 80% and interventions are needed to attract the 20% who are missing out on screening. This prospective observational study is designed to measure the impact of a physician intervention in a usual healthcare environment, amongst a heterogeneous patient population to yield replicable real-world results. The intervention arm will receive a physician intervention to inform them of their overdue screening status, remind them of the importance of cervical screening and guide them to book a screening appointment. The screening rate in the intervention arm will be compared to a control made up of patients seen by other clinicians and receiving unstructured reminders. The results will assist physicians in deciding whether a structured intervention is anymore effective than the unstructured advice currently given at improving screening rates in the non responder population.

Eligibility Criteria:
Inclusion Criteria:

* Registered patient with a cervix
* Non responder to cervical screening invitation

Exclusion Criteria:

* Incorrectly reminded i. Coding errors ii. Human error
* Temporary patients i. Did not remain registered for minimum of 6 months following intervention
* Screening refusal
* Inappropriate to include i. Terminal illness ii. Prolonged hospitalisation iii. Death due to non-cervical cancer attributable cause
JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation

This Phase 3 study will evaluate the efficacy of JAB-21822+JAB-3312 versus tislelizumab (PD-1 Ab) combined with pemetrexed+carboplatin as the first line treatment in subjects with KRAS G12C mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).


Eligibility Criteria:
Inclusion Criteria:

* A signed written informed consent is required before performing any study-related operations
* Age greater than or equal to 18 years old
* Histologically or cytologically confirmed locally advanced/metastatic, unresectable non-squamous NSCLC with KRAS p. G12C mutation confirmed by the central lab
* No history of systemic anticancer therapy to the local advanced/metastatic disease
* Expected survival period greater than or equal to 3 months
* Having at least one target lesion according to RECIST 1.1
* Eastern Cooperative Oncology Group (ECOG) ≤ 1

Exclusion Criteria:

* Previous (≤2 years) or current solid tumors or hematologic tumors of other pathological types
* Carry other driver gene mutations with available target therapy, or carry other KRAS mutations
* Subjects with untreated central nervous system (CNS) metastases were excluded;
* Uncontrolled pleural effusion, pericardial effusion, and ascites
* Subjects with impaired heart function or clinically significant heart disease
Study Evaluating Inhibitor Specificity in Hemophilia A

This investigation will utilize a systematic determination of anti-FVIII antibody specificity in PTPs (\> 50 ED) with hemophilia A who have developed inhibitors in response to treatment with any FVIII product(s). A group of patients with hemophilia A, who have no evidence of current or prior FVIII inhibitor will be included for comparison. The objective of this study is to describe the patterns of antibodies and associated epitopes in the study population.


Eligibility Criteria:
Inclusion Criteria:

· Patients with moderate or severe congenital hemophilia A, a current FVIII inhibitor, who have taken at least two different FVIII products during their lifetime.

Exclusion Criteria:

* Patients who have had an inhibitor prior to their current inhibitor.
* Patients with immune disorders.