cyrilzakka/clinical-trials huggingface dataset:
Power Training on Muscle Quality and Functional Capacity in Women Aged 65-75.

Muscle power training has proven to be an effective intervention to prevent sarcopenia and frailty in old people. In the last decade, new concepts related to the functionality of old people have been generated, such as muscle quality and functional capacity.

The power training consists of rapid movements of short duration that imply a more specialized neuromuscular response and that improve the functional response reflected in activities of daily life that demand a certain manifestation of muscular power (stand up of a chair, climbing stairs, rebalance, accelerate suddenly, among others). Therefore, it is important to investigate the dose-response relationships in power training in older people and establish how possible improvements in muscle quality can be reflected in functional capacity.

The aim of this study is to compare the effects of power training at two different loads on muscle quality and functional capacity in women aged 65-75

Fifty-six women will be randomly assigned to one of two muscle power training supervised for a physical activity instructor with different velocity loss (VL) thresholds: 10% (VL10) and 30% (VL30). Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min.

Before and after the muscle power training the following tests will be performed: 1) measure of body composition with dual-energy x-ray absorptiometry for determining the lean mass of thighs; 2) three functional test (chair stand test, time up go test with cognitive task and gait speed test); 3)Progressive loading test in a leg extension machine until finding the mean muscle power corresponding to 50% of 1RM (speed of concentric phase of 6.67 ± 0.04 m/s measured using a camera-based optoelectronic system).

Eligibility Criteria:
Inclusion Criteria:

* Women 65 to 75 years.
* Healthy volunteers.
* Have not perform muscle power training in the last six months.

Exclusion Criteria:

* History of asthma.
* History of uncontrolled diabetes.
* History of uncontrolled hypertension.
* History of cardiovascular disease.
* History of coronary heart disease.
* Smoker.
* Arrhythmias.
* Personal history of surgical procedures in the last three months.
* Uncontrolled non-communicable diseases.
* Psychological, sensitive, cognitive, neuromotor and/or osteo-muscular conditions that may affect participation in an exercise program.
* Under medical treatment with anticoagulants, bronchodilators, and/or steroids.
Anti-inflammatory Effect of Atorvastatin on Graft Donor Kidney

Renal Insufficiency is a priority disease in health system, which may require renal replacement therapy based on renal transplantation, which is considered as therapy of choice. During the procedure of renal transplantation, the graft could be damaged by ischemia-reperfusion which generates complications in its function.

Recently the anti-inflammatory and immunomodulatory effects of statins have been emphasized, which could be beneficial in renal transplantation.

Objective: Evaluate anti-inflammatory effect of atorvastatin on renal graft in living donor transplantation.

Material and methods: Controlled, double-blind clinical trial with posterior following for 12 months. Composed by 48 patients, randomized manner, realized at the Transplant Department of Western Medical Center, Mexican Institute of Social Security. Universe was patients accepted as kidney donors. Patients were randomized in two groups (study or control) the intervention was implemented 4 weeks before kidney transplant. Previous surgical procedure, in a blood sample, C-Reactive Protein (C-RP) and laboratory control were measured. During surgical procedure, a biopsy was obtained to measure IL-6 and tumoral necrosis factor alpha by immunohistochemistry. 24 hours after surgical procedure, 3 and 12 months of following, kidney function, complications and graft survival were registered. During surgical procedure, 3 months and 12 months of following, biopsies were obtain to performed histopathological analysis of scale of Banff

The statistical analysis was performed according to the nature of variables, for continuous data using measures of central tendency and dispersion and for the qualitative data with frequencies and percentages.

Eligibility Criteria:
Inclusion Criteria:

* Accepted as kidney donor
* Voluntary participation
* Informed consent accepted
* 85% fulfillment of atorvastatin treatment

Exclusion Criteria:

* Hypersensibility to Atorvastatin
* Smoking
rTMS Improves Functions in Spinocerebellar Ataxia

Spinocerebellar ataxia (SCA) is a group of inherited brain disorders. SCA often result in poor limb coordination. This study aims to discover the effects of repeated transcranial magnetic stimulation (rTMS) on balance \& gait in SCA. The hypothesis of this study is that rTMS might improve SCA limb functional performance.

rTMS has been shown that improves walking speed and balance performance, however, the optimal treatment protocols have not been approved. Past studies used different frequencies 1 Hz, 5 Hz and 10 Hz to improve functional performance. The results might be affected by the types of SCA. In this study, we will focus on the SCA type 3 to assess the effects on high frequency (10 Hz) of rTMS intervention.

Eligibility Criteria:
Inclusion Criteria:

* SCA type 3
* independently walk with/without an assistive device
* SARA greater than 3

Exclusion Criteria:

* Epilepsy history
* Unstable blood pressure
* Brain Trauma
* Alcoholism, drug abuse, antipsychotics drug use
* Metallic hardware (e.g. - cochlear implants, brain stimulators or electrodes, aneurysm clips) anywhere in head.
* Dementia, depression
Pelvic and Hip Morphometry in Piriformis Syndrome

In this case-control study, 23 patients diagnosed as PS by diagnostic injection with ultrasound guidance were selected as the study group. 22 patients who were excluded from the diagnosis of PS and had anteroposterior (AP) direct radiographic imaging were evaluated as the control group. On the AP Pelvic graph, the femoral neck-shaft angle, the distances between predetermined bony landmarks were measured blindly without knowing the diagnosis, and the findings were compared statistically.

This study aims to evaluate whether the anatomical structure of the pelvis predisposes to the etiopathogenesis of the piriformis syndrome.

Piriformis syndrome (PS) is a neuromuscular disorder consisting of pain and symptoms caused by compression of the sciatic nerve and other structures that pass under the piriformis muscle (PM). Due to difficulties in diagnosis, PS is confused with other pathologies such as lumbar disc pathology, lumbosacral radiculopathy, and sacroiliac dysfunction. As a result, patients are exposed to unnecessary and ineffective treatments, even surgery. The main problems in the PS diagnosis are the absence of objective physical examination findings, radiological findings, and a clear etiology. When the pathophysiology and etiology of PS are considered, there is no identifiable cause in most patients. Previous studies suggest that trauma, anatomical variations, and the trigger point in the muscle may cause PS. No study in the literature radiologically examined the pelvis or hip bone morphological features in PS to the best of our knowledge. This study aims to determine whether pelvic or hip bone morphology features pose a risk for PS in this study.

Eligibility Criteria:
For Piriformis syndrome group (study group);

Inclusion Criteria:

* A dramatic relief of pain following piriformis muscle local anesthetic injection

Exclusion Criteria:

* Having a neurological deficiency
* Having lumbar, sacroiliac, hip, and thoracolumbar pathology (inflammatory or degenerative)
* Operation history at the lumbar and hip region
* Being in the gestational or lactational period
* Body mass index of greater than 35
* History of inflammatory or infectious disease
* Active psychiatric illness, severe systemic, vascular or malign disease

For the control group

Inclusion criteria:

-Having Anteroposterior pelvic radiographs for other medical reasons

Exclusion criteria:

* Having a present piriformis syndrome or a history of piriformis syndrome
* Having a neurological deficiency
* Having lumbar, sacroiliac, hip, and thoracolumbar pathology (inflammatory or degenerative)
* Operation history at the lumbar and hip region
* Being in the gestational or lactational period
* Body mass index of greater than 35
* History of inflammatory or infectious disease
* Active psychiatric illness, severe systemic, vascular or malign disease
Surgeon's Performance in Predicting Postoperative Infections

Post-surgical (bacterial) infections are the most frequent post-surgical complications, including deep or superficial wound infections, urinary tract infections, pneumonia, and even sepsis. Approximately 6.5-25% of all surgical patients will develop any type of bacterial infection. To personalize surgical infection management, (Artificial Intelligence) models are in the making to predict which patients are at high or low risk of developing a post-surgical infection. In order to benchmark these prediction models to the predictive capabilities of surgeons, the investigators aim to investigate the performance of surgeons in predicting the risk of a patient developing (any type) of post-surgical infection within 30 days.

A prospective non-interventional study is performed to collect surgeons' predictions on the risk of a patient developing a postoperative infection within 30 days of surgery. Surgeons are asked to fill in a short questionnaire asking about the estimated infection risk. The actual outcome (infection \< 30 days of surgery) of a patient will be collected retrospectively after completion of the study. This study will have no effect on standard care: surgical interventions and postoperative care will be carried out according to standard clinical practice. Besides a one-time estimate of the surgeon, immediately after the surgical procedure, no other interventions will be performed and surgical specialists will carry out their normal post-surgical care, including screening and treating (if necessary) their patients for postoperative infections.

Eligibility Criteria:
Predictions are made for patients with the following inclusion and exclusion criteria:

Inclusion Criteria:

* Adult patients (\>18 years old)
* Acute or elective surgery
* Invasive or minimally invasive surgical procedures

Exclusion Criteria:

* Outpatient procedures or procedures not requiring any form of monitoring/anesthesia
* Procedures for which the primary indication is (treatment for) an infection
* Radiological procedures
* Cardiological catheterization procedures
* Psychiatric treatment under anaesthesia (i.e. electroconvulsive therapy)
* Sole anaesthetic procedures except for implantation of a neurostimulator
* Brachytherapy procedures
* Endoscopic procedures for diagnostic purposes only
* Procedures that only entail the taking of a biopsy for diagnostic purposes
* Patients that are pregnant
* Procedures out of office hours (before 8.00 am or after 5.00 pm)
Effect of Beetroot Juice Supplements on Lower-limb Strength in Females

This study aims to evaluate the effects of beetroot juice supplements on lower-limb strength and muscular endurance in physically active women, due to the presence of NO3- in beetroot juice.

Beetroot juice (BJR) is used as an ergogenic aid, but no study has analyzed its' effects on explosive force production in physically active women. It has been proposed that females could blunt reduction of NO2- to NO based on a higher oxidative skeletal muscle phenotype than males. However, it has been observed a higher increase on plasma NO2- levels after supplementation compared to and a greater enhancement on muscle contractile function.

Based on the absence of any study that has analyzed the effect of NO3- supplements on jump ability and power production on weightlifting on female population; the purpose of this study will be to investigate the possible ergogenic effect of BJR on physically active women on explosive force production and muscular endurance in a lower-limb body weightlifting protocol, due to the presence of NO3- in BJR and its effects.

Eligibility Criteria:
Inclusion Criteria:

* Physically active females with 18-30 years of age
* More than 6 months on RT training programs
* Be familiarized with back squat, leg press and leg extension exercises
* Not consuming any type of nutritional supplement or anabolic substances in the previous three months or during the study
* Not suffering from a musculoskeletal injury that could interfere with the exercise protocol during the investigation

Exclusion Criteria:

* None
Efficacy of EPSW Plus HILT on Carpal Tunnel Syndrome Post Burn Injury

To study the effect of adding ESWT as a noninvasive short-term treatment plus high-level laser therapy for moderate carpal-tunnel syndrome post-burn injuries.

To study the effect of adding ESWT as a noninvasive short-term treatment plus high-level laser therapy for mild to moderate carpal tunnel syndrome post-burn injuries.

The effects of combining EPSW with High-intensity Laser Therapy for improving pain, Symptoms and function of motion, muscle strength, and quality of life in inpatients with carpal tunnel syndrome post-burn injuries

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with carpal tunnel syndrome after thermal burn injuries.
* Patients will be diagnosed with median nerve conduction study and Phalen sign and tinel test.
* Patients age: 20 to 60 years

Exclusion Criteria:

* Patients with severe (absent sensory or motor waves) and mild (sensory nerve latency \>3.5 ms at third digit) CTS according to EMG-NCV study.
* Conditions that could impact upon or impacted by outcome measures or laser intervention (e.g. hypothyroidism, cancer, active infection, pulmonary disease, acquired immunodeficiency syndrome, associated myopathy, myelopathy, history of neck and/or shoulder surgery, drugabuse, corticosteroids consumption, and pregnancy)
* Patients received continuous physical therapy or exercise during the previous two weeks or taking analgesic or anti-inflammatory drugs during the week prior to the baseline assessment
Cupping in Osteoarthritis of the Knee

The purpose of this exploratory randomised trial is to study the effect of pulsatile cupping in osteoarthritis of the knee compared to waiting list control.

Cupping is a traditional therapy in many cultures of the world and is used to treat osteoarthritis of the knee. In this randomised trial we want to study the effect of pulsatile cupping in osteoarthritis of the knee compared to waiting list control. Pulsatile cupping is administered by a special cupping machine (HeVaTec) with silicone cupping glasses to the knee joint. Pulsatile pressure is generated by a pump that generates vacuum.

Eligibility Criteria:
Inclusion Criteria:

* Osteoarthritis of the knee according ACR-criteria
* X-ray classification minimum Kellgren-Lawrence criteria grade 2
* Pain Intensity \> 40 mm VAS
* Only therapy with NSAIDin the last 4 weeks
* Informed consent

Exclusion Criteria:

* Use of anticoagulants (Phenprocoumon, Heparin)
* Coagulopathy
* Cupping in the last 12 months
* Intraarticular injection of corticosteroids or NSAID into the knee joint in the last 4 months
* Use of systemic corticosteroids in the last 4 weeks
* Physical therapy, leeches or acupuncture in the last 4 months
* Other CAM therapies for the osteoarthritis in the last 4 weeks
* Arthroscopy of the knee joint in the last 12 months
* Paracetamol allergy or intolerance
Compare The Effect of Pendulum Exercises With the Kaltenborn Mobilization Among the Patients of Adhesive Capsulitis

To determine the effect of pendulum exercises with the kaltenborn mobilization among the patients of adhesive capsulitis


Eligibility Criteria:
Inclusion Criteria:

* Subjects will be of the age group of 40-60 years.
* Can be male or female
* Diagnosed with adhesive capsulitis by orthopedic or physical therapist.
* Pain, stiffness, and limitation of passive shoulder lateral rotation, abduction, and internal rotation of more than 50% compared with the opposite side for at least 3 months

Exclusion Criteria:

* Presence of neurological disorders (e.g., stroke, Parkinson's disease) leading to deficiency of shoulder muscles activity, Severe trauma related to painful stiff shoulder which leads to bony changes of the affected shoulder on radiographs, Previous surgeries and manipulation under anesthesia of the affected shoulder
Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage

The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI. Assessment of cerebral autoregulation with transcranial Doppler (TCD) may improve the prediction of DCI. The aim of this prospective study was to assess the value of TCD-derived variables to be used alone or in combination for prediction of DCI


Eligibility Criteria:
Inclusion Criteria:

Group 1 : • Patients who presented a ruptured aneurysm by aneurysmal subarachnoid hemorrhage (SAH) older than 72 hours. Diagnosis of SAH was confirmed by computed tomography, magnetic resonance imaging (MRI) or lumbar puncture as recommended

* symptomatic aneurysm treated with endovascular,
* Absence of achieving a lumbar puncture,
* Patients affiliated to a social security scheme,
* Patients who have given their free and informed consent and signed the consent or consent of the family.

Group 2 :

healthy volunteers with cerebrospinal fluid sample

Exclusion Criteria:

* Patients with no readable acoustic temporal bone window
* Patients with previous disease that might impair cerebral autoregulation (e.g., carotid stenosis, history of stroke or head injury).
Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery

This study on minor surgery serves to explore whether a dose-response relationship exists between surgical stress and endothelial dysfunction in the early postoperative period. The aim of this explorative and observational clinical study is to closely examine the endothelial function and its dynamics in the early postoperative period after minor surgery (lap. inguinal hernia repair). The endothelial function will be assessed indirectly by EndoPat and plasma biomarkers of nitric oxide bioavailability. The study will contribute to the understanding of perioperative myocardial injury, which is crucial for optimized treatment of patients at risk of cardiovascular complications.

The investigators will include 60 patients undergoing elective inguinal hernia repair. The endothelial function will be measured before surgery and 4 hours after surgery with the EndoPat system. The NO-bioavailibility will be measured by plasma l-arginine, plasma ADMA and plasma biopterins.

Eligibility Criteria:
Inclusion Criteria:

* Patients scheduled for a laparoscopic inguinal hernia repair
* Patients ≥ 18 years old

Exclusion Criteria:

* Not capable of giving informed consent after oral and written information
* Previously included in the trial ￼￼ - Surgery within 7 days of the trial
Single Focused Shock Wave in the Release od Delayed Onset Muscle Soreness (DOMS)

The study is a single-center, double blinded, randomized controlled trial aimed to investigate the effects of focused extracorporeal shockwave therapy (fESWT) on Delayed Onset Muscle Soreness (DOMS) of the non-dominant biceps brachialis muscle in healthy voluntary adults.

Forty-five participants agreed to participate and signed a written informed consent. After enrollment, muscle soreness was induced and participants were subsequently randomized to receive either (1) focused extracorporeal shockwave therapy (Verum), (2) sham shock wave (Sham) or (3) no treatment (Control). Thereafter, treatments were administered once, only. Measures were repeated after the treatment and at 24, 48 and 72 hours. Main outcome parameter was the pain intensity at rest and in movement as assessed by visual analogue scale (VAS) in the elbow region of the non-dominant arm. Secondary outcome included the pressure pain threshold (PPT) over the biceps muscle belly, the maximum isometric voluntary force (MIVF) of the elbow flexors and the assessing the impairment of activities of the daily living. Participants were followed-up 72 hours after the induction of Delayed Onset Muscle Soreness.

Eligibility Criteria:
Inclusion Criteria:

* healthy subjects
* age 18+
* voluntariness

Exclusion Criteria:

* pain
* pregnancy
* musculoskeletal disease
* systemic neurological disease
* cancer
* coagulation disorder
* mental illness
* drug addiction
* allergy to the ultrasound gel
* cardiac illness
* vascular disease of the limbs or the central nervous system
* regional scars
* regional skin transplants or hypoesthesia
* allergic or other forms of acute dermatitis
* chronic intake of analgesic, neuroleptics, antidepressants, corticoids or alpha2-blockers
* current state of delayed onset muscle soreness
* extracorporeal shockwave therapy within last 2 weeks