cyrilzakka/clinical-trials huggingface dataset:
Effect of Electrical Stimulation on Forward Head Posture

The study aims are:

1. To investigate the effect of electrical stimulation (interferential current) on forward head posture and protracted shoulder in adolescents.
2. To investigate the effect of electrical stimulation on cervical pain, cervical ROM, neck muscle strength, and quality of life in adolescents with forward head posture and protracted shoulder.

Forward head posture (FHP) is commonly defined as the protrusion of the head in the sagittal plane so that the head is placed anterior to the trunk. It can occur because of anterior translation of the head, and it is claimed to be associated with an increase in upper cervical extension, lower cervical flexion, or both.

Patients with FHP often experience neck pain and disability, it is associated with shortening of the upper trapezius, the posterior cervical extensor muscles, the sternocleidomastoid muscle, and levator scapulae muscle. Thus, FHP may contribute to neck and shoulder pain.

The prolonged uses of mobile phones and computers have led to a variety of musculoskeletal disorders, especially related to the neck as: Forward Head Posture (FHP), rounded shoulders (RS), upper cross syndrome, mechanical neck pain etc. FHP is one in which the upper cervical convexity is increased and the lower cervical convexity is decreased causing anterior weight bearing of the cervical spine. It is also known as Scholar's neck or Reading neck.

Electrical muscle stimulation (EMS) has been used as a complementary training method, applied either locally or to the whole body. It activates muscles artificially through various electrical current forms, which are delivered through electrodes on the target muscles.

Interferential current (IFC) is an established therapy which is used to treat pain and also effective for providing relaxation of muscles. The application of IFC at the medium frequency which suggests higher penetration of the electrical stimulation in the tissue by reducing tissue impedance

Eligibility Criteria:
Inclusion Criteria:

* Girls aged between (15-18) years old.
* Normal weight with BMI ranging from (16-25).
* Adolescents with mild and moderate forward head posture(FHP).
* Adolescents with mild and moderate neck pain.
* Adolescents with protracted shoulder.

Exclusion Criteria:

* Cervical disc.
* Previous Shoulder trauma within last 6months.
* Shoulder surgery.
* Cervical fracture.
* Congenital posture deformity.
* Inflammatory disease, spinal tumor, spinal compression, spinal cord infection.
* Taking any medication for pain
Pilot Study Testing a New Strategy for Management of Spontaneous Preterm Birth

Preterm birth is a major public health problem, and actual treatments are not very efficient. The purpose of this study is to test the efficiency of a combined use of Montelukast and Nifedipine to treat preterm labor. Investigators aim to reduce uterine contractions more efficiently than with the use of Nifedipine only.

An inflammatory process is involved in 60% of preterm births. Moreover, investigators previously demonstrated that enzymes of lipoxygenase pathway are present in uterine smooth muscle, and that an additive tocolytic effect can be obtained from the combined use of Montelukast and Nifedipine.

Methods:

This is a double-blinded randomized controlled assay performed at the CHUS on two groups of 50 women. Women will be selected when admitted for preterm labor with a gestational age between 26 and 34 weeks.

The first group will receive Nifedipine for 48 hours, as described by the standard protocol at the CHUS, in addition to 10 mg of Montelukast per day, until delivery or 35 weeks of pregnancy.

The second group will receive Nifedipine for 48 hours, as described by the standard protocol at the CHUS, in addition to a placebo per day, until delivery or 35 weeks of pregnancy.

Cervical secretions and urine will be sample at the admission, after one week and every two weeks during treatment.

Eligibility Criteria:
Inclusion Criteria:

* women with 24-34 weeks of pregnancy
* indication for tocolysis

Exclusion Criteria:

* preterm labor before 26 or after 34 weeks of pregnancy
* minor patients
* patients with other obstetrical pathology
* twin pregnancies
* fetal distress
* severe congenital fetal malformation
* anti-phospholipid syndrome
* lupus
* gestational diabetes
* nephropathy
* congenital heart disease
* obvious causes of infection associated with prematurity
* patients with viral infections (HIV, hepatitis)
* patients already treated with Montelukast
Fecal Microbiota Transplantation in Patients With Ulcerative Colitis

The purpose of this study is to find out whether a single fecal microbiota transplantation is an effective and safe treatment as an adjunct to standard therapy in patients with ulcerative colitis.


Eligibility Criteria:
Inclusion Criteria:

* active ulcerative colitis (PUCAI 10-64) in whom fecal microbiota transplantation via colonoscope can be performed

Exclusion Criteria:

* severe ulcerative colitis (PUCAI \> 65)
Immersive Virtual Reality Exergaming Program in Adolescents Diagnosed With Juvenile Idiopathic Arthritis

The aim of the study is to investigate the effect of home-based exercise program versus personalized IVR exergame (Fit-XR) program on physical fitness, functional capacity and physical activity in adolescents with Juvenile idiopathic arthritis. Patients followed up by four tertiary pediatric rheumatology centers will be included in the project. Two different exercise programs will be applied to the patients by experienced physiotherapists. Fit-XR program will be 25-30 minutes a day and will be applied 2 days a week for 8 weeks under the supervision of a physiotherapist in the clinic. The total points obtained by the participants during the FiT-XR games will be recorded after each training session. In the second group, a personalized multicomponent (balance, strength, agility, endurance) home- based exercise program will be applied according to the physical fitness level of the children.


Eligibility Criteria:
Inclusion Criteria:

* Having a definitive diagnosis of JIA according to the ILAR classification at least 6 months ago
* Being between the ages of 13-18

Exclusion Criteria:

* JIA diagnosis was made less than a month ago
* Having had a surgical or arthroscopic operation within the last year
* Presence of active synovitis or arthritis
* Have a disease that may limit the ability to exercise or increase the cardiovascular risk of exercise, including cardiovascular, pulmonary, musculoskeletal, or metabolic disorders
* Having active vestibular disease
* Having a neurological disease that prevents walking and exercising
* Having been exercising regularly for the last 6 months
* Having severe vision and hearing problems
* Use of any medication or supplement known to increase anabolic responses
* Having mental inability to understand the exercises
Transcranial Magnetic Stimulation in Depression

The study examines efficacy of repetitive transcranial magnetic stimulation in treating severely depressed patients who are medicated.

Medicated, treatment resistant, depressed patients are randomized to active or sham repetitive transcranial magnetic stimulation (rTMS). Responding patients go into a six months follow-up period.

Eligibility Criteria:
severe treatment-resistant depression
Oral State of Patients Affected by an Oral Cancer Before and After Radiotherapy - 3-years Prospective Study

Context: the oral cancer is the 5th cancer in order of frequency for human in France. It is the country where the mortality by oral cancer is the most raised in Europe. The most frequent location concerns the oral cavity prevalency of which is one of higher in the world. The main risk factors are the tobacco and the alcohol.

The oral cancer is treated in the great majority of the cases by radiotherapy which is going to pull xerostomy, responsible for the degradation of the oral state. Furthermore, it will increase the risk of appearance of osteoradionecrosis (ORN) when the patient is carrier of buccal lesions and\\or when he will have to undergo surgical acts. Consequently, the initial oral state of the patients is to be estimated so as to eliminate any source of the infection. An unfavourable initial state will increase the risk of degradation of this one and appearance of ORN. However, at present few epidemiological data are available concerning the oral state of the patients presenting an oral cancer.

Objective: the main objective of this study is to describe, before radiotherapy, the oral state of the patients presenting an oral cancer and to follow the evolution of this oral state for three years and to register the patients quality of life. The secondary objectives are to describe the distribution of risk factors of the degradation of the oral state (oral hygiene, food habits, xerostomy, consumption of tobacco and alcohol) in this population and to register the impact of the dental restorations on the radiological assessment.

Methods: this prospective epidemiological study of observation will be realized in the service of odontology of the Timone hospital (Marseille, France) in association with the services of ORL and maxillofacial surgery of Timone as well as the services of radiotherapy and medical oncology of Timone and Paoli Calmettes institute (IPC). All the toothed patients affected by an oral cancer untreated will be included, or treated surgically only, of more than 18 years old and for whom an initial dental assessment will be realized. The main assessment criteria will be the CAD index and the parodontal state.

Expected results and perspectives: This study will allow to have epidemiological data concerning patients' oral state affected by an oral cancer before and after radiotherapy. It will allow to set up a consensus of good practice.


Eligibility Criteria:
Inclusion Criteria:

* Patient with a first oral cancer
* Patient with teeth
* Patient not yet treated for the oral cancer

Exclusion Criteria:

* Patient with a cancer already treated or with an oral cancer ongoing treatment.
* Patient without teeth
* Patient with trouble for comprehention and without capabilities for brushing teeth
Complementary and Alternative Medicine Among Outpatients With Inflammatory Rheumatic Diseases in Western Sweden

This is an observational study aiming to study the use of complementary and alternative medicine (CAM) drugs and methods among patients with inflammatory rheumatic diseases, at Rheumatology clinics in western Sweden and also to investigate possible associations between CAM using habits and other characteristics of the patients.

Complementary and alternative medicine (CAM) is treatment that primarily is given outside the institutions where conventional medicine is practised. CAM drugs are substances that often have a natural origin and are taken orally or used topically, for self-treatment. CAM methods are therapies where the patient often goes to a practitioner, for example acupuncture, massage, homeopathy or chiropractics.

Most cultures have their own history of traditional treatments, with herbal medicine or spiritual healers.

The use of complementary and alternative medicine (CAM) is widespread and increasing in many countries. The sales figures in Sweden for CAM drugs, functional foods and dietary supplements have increased from 450 million to 4250 million SEK between 1980 and 2007. Many people of today use CAM as a complement, rather than an alternative, to conventional healthcare. Some alternative methods, like acupuncture and massage, have also been integrated into conventional medicine.

The biological effects of drugs containing herbs or animal parts are often unknown and there is a hazard of interaction with prescribed medication.

The use of CAM drugs is often not communicated by the patient to the physician. A Swedish point observation study of patients admitted to Sahlgrenska hospital 2004 showed that 69 % of the patients had used CAM drugs at any time in their life, but only 27,5% had informed their doctor about it. The use of CAM drugs was seldom documented in the medical records of the patient.

The utilization of CAM among patients with rheumatic diseases in Sweden has never been studied before.

The aim of this trial was to study the use of CAM methods and CAM drugs among patients seen at rheumatology practises in the west of Sweden. To investigate which methods and drugs that are being used and to see if there are connections between using habits and factors like gender, age, rheumatic diagnoses, disease activity, medication and the patients experience of pain, fatigue and general health. We were also interested in finding out the reason for use of CAM, and if the patients had experienced beneficial effects or side effects of the use.

Eligibility Criteria:
Inclusion Criteria:

* Patients were eligible for inclusion if they were attending the rheumatology clinic and had had an appointment there before.

Exclusion Criteria:

* Patients were excluded if they were on their first visit to the practice, had dementia or had difficulties understanding Swedish.
Endoscopic Plantar Fascia Release in Cases of Chronic Resistant Plantar Fasciopathy

The plantar fascia is a thick tissue band that connects the heel bone (the medial tubercle of the under surface of the calcaneus) to the metatarsophalangeal joints, forming the medial arch of the foot, which supports the foot during walking. Irritation and scarring of the plantar fascia is one of the most common causes of heel pain .

Plantar fasciopathy accounts for 11% to 15% of all foot disorders in both athletes and sedentary patients .

Although commonly referred to using incorrect nomenclature as plantar fasciitis ,it is degenerative process (i.e. fasciopathy).The etiology of plantar fasciopathy is not clear. It can result from irritation due to overstrain of the fascia, which induces mucoid degeneration The pathologic ﬁndings include degenerative tissue changes without inﬂammatory mediators .

The diagnosis of plantar fasciopathy is determined by the medical history and physical examination ﬁndings. Typically, patients present with heel pain during weight bearing , especially in the early morning and with the ﬁrst steps after a period of inactivity .

Patients will usually have tenderness around the site of the plantar aponeurosis . The pain can be reproduced by stretching the diseased plantar aponeurosis by passive hyperextension of the metatarsophalangeal joints .

Endoscopic plantar fasciotomy is a relatively new procedure, involves an endoscopic approach to the heel, allowing a plantar aponeurosis release to be performed with delicate instruments, minimal dissection, and immediate weight bearing


Eligibility Criteria:
Inclusion Criteria:

* Adults more than 18 years old presented by a single site heel pain with local pressure at the origin of plantar fascia on the medial Calcaneal tuberosity for one year, with failure of at least two lines of conservative treatment including:

Non-steroidal anti-inflammatory drugs (NSAIDs), Corticosteroid injections, physical therapy, exercise program (Achilles tendon and plantar fascia stretching exercises) and orthotic devices (heel cup, molded shoe insert or night splint) for at least 3 months.

Exclusion Criteria:

* Patients younger than 18 years.
* Patients who had a local infection or a metabolic disorder especially diabetes, generalized polyarthritis, sero-negative arthropathy, , tarsal tunnel syndrome.
* Patients with congenital anomalies e.g pesplanus, pescavus, limb length discrepancy, in-toeing, neuro-muscular disorders.
* Patients with an ipsilateral or contralateral vascular or neurological abnormalities, or malignancies.
* Recent trauma or foot and ankle deformity or fractures.
* Active anticoagulation therapy or bleeding disorders
* Patients who received a corticosteroid injection within the previous four weeks.
Brain Vital Signs M-Score: Point-of-care Monitoring for Motor Recovery After Stroke

The purpose of this study is to investigate brain signals relating to motor function, using electroencephalography (EEG) technology. The aims of the study can be separated into 3 specific study objectives:

1. Record EEG data from control participants and individuals with stroke during basic motor tasks and build a database of EEG signals to enable analysis of motor control.
2. Apply signal processing algorithms to extract EEG features related to motor control.
3. Develop a framework/the motor score (M-Score) that uses the EEG signals, in combination with machine learning approaches, to quantify motor control ability.


Eligibility Criteria:
Inclusion Criteria:

* Age requirements:

  * Younger adult control participants (19-40 years old)
  * Older adult control participants (41-80 years old)
  * Individuals with stroke (19-80 years old)
* Capacity to follow single stage commands
* Stroke specific inclusion criteria

  * Upper-limb disability as a result of a stroke (\>1 month ago)

Exclusion Criteria:

* Cognitive difficulties that undermine ability to give informed consent (Montreal Cognitive Assessment (MoCA) score below 23).
* Severe paralysis such that the participant cannot perform simple movements (such as finger tapping, clicking a mouse, etc.)
* History of head trauma, a major psychiatric diagnosis, neurodegenerative disorder or substance abuse
Mechanism of Dipyridamole Action in Platelets: in Vivo Study With Healthy Volunteers

Investigation of the mechanism of dipyridamole action in platelets in an in-vivo study with healthy volunteers treated Aggrenox in comparison with volunteers treated with Persantin Retard or Acetylsalicylic Acid using platelet Vasodilator-Stimulated-Phosphoprotein (VASP)-phosphorylation as indication for an action and measurements of dipyridamole plasma levels


Eligibility Criteria:
Inclusion Criteria:

* Healthy females/males
* Age range from 18 to 60
* Volunteers will have given their written informed consent in accordance with local ethics committee and local legislation

Exclusion Criteria:

* Known gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders
* Diseases of the nervous system (such as epilepsy) or with psychiatric disorders or neurological disorders
* Known history of orthostatic hypotension, fainting spells or blackouts
* Chronic or relevant acute infections
* History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator
* Drug intake with long half-life (\> 24 hours), \< 1 month prior to administration or during the trial
* Volunteers received any other drugs which might influence the results of the trial, \< 10 days prior to administration or during the trial
* Participation in another study with an investigational drug, \< 1 month prior to administration or during the trial
* Smoking more than 15 cigarettes or 4 cigars or 4 pipes/day
* Drinking more than 60 g of alcohol per day
* Unable to refrain from excessive consumption of methylxanthine containing drinks or food
* Drug addiction
* Blood donation (\> 400 ml), \< 4 weeks prior to administration or during the trial
* Participation in excessive physical activities, \< 5 days prior to administration or during the trial

For female volunteers:

* Pregnancy
* Positive pregnancy test
* No adequate contraception (acceptable: oral contraceptives, condoms, etc.)
* Lactation period
Transcutaneous Bilirubinometry and Phototherapy

A randomized Controlled trial comparing the use of transcutaneous bilirubinometry to serum bilirubin measurements (via blooddraws = standard care) in neonates born after a gestational age \> 32 weeks and \< 15 days of age treated with Phototherapy for neonatal hyperbilrubinemia.

A randomized Controlled trial comparing the use of transcutaneous bilirubinometry to serum bilirubin measurements (via blooddraws = standard care) in neonates born after a gestational age \> 32 weeks and \< 15 days of age treated with Phototherapy for neonatal hyperbilrubinemia. Main outcome measurement is the number of blooddraws for measurement of bilirubin. Secondary outcome measurements are duration of phototherapy and hospitalisation.

Eligibility Criteria:
Inclusion Criteria:

* Neonates with indication for phototherapy for treatment of hyperbilirubinemia

Exclusion Criteria:

* skinlesions located on the sternum interfering with transcutaneous measurement
* exchange transfusion
Bright IDEAS for Pediatric Palliative Care: A Problem-Solving Skills Intervention to Empower Parent Resilience

The goal of this or clinical trial is to test in the feasibility, acceptability and preliminary efficacy of the bright IDEAS problem solving skills training for parents of children in palliative care. The main questions it aims to answer are:

* Is bright IDEAS problem solving skills training feasible and acceptable for parents of children referred to pediatric palliative care?
* Does bright IDEAS reduce psychological distress in parents compared to parents receiving standard palliative care support?

Participants will:

* Participate in 6-8 sessions of the bright IDEAS program.
* Complete self report measures of psychological distress and well being.

If there is a comparison group: Researchers will compare bright IDEAS to standard palliative care support.


Eligibility Criteria:
Parent

Inclusion Criteria:

* Parents or legal guardians of male and female children (ages 0-21) of any race or ethnicity and of any underlying medical diagnosis
* Child received at least one consult from the Comfort and Palliative Care team within the past month
* One parent or primary caregiver per child
* Able to speak, read, and write English or Spanish, and give informed consent

Exclusion Criteria:

* Parent age less than 18 years old
* Concurrent enrollment on another research study testing psychoeducational interventions for parents and/or patients
* Child has an estimated life expectancy of less than 4 months at time of study recruitment

Child

Inclusion Criteria:

* Children 8-17 years of age whose primary caregiver has consented to participate
* Able to read and write English or Spanish and assent

Exclusion Criteria:

• Parent refusal to participate
Evaluation of Two Different Types of Zirconia Crowns Used in Carious Primary Anterior Teeth

Evaluation of two different types of zirconia crowns ( Kinder Krown , Nusmile crown) used in carious primary anterior teeth

Assess the clinical and radiographic evaluation of Kinder Krowns and Nusmile crowns in restoring carious primary canines And compare between the two crowns used

Eligibility Criteria:
Inclusion Criteria:

* Children age ranging from 7 to 10 years
* Deep carious primary upper canines
* The tooth need pulpal treatment
* The tooth need a crown restoration
* The tooth not submerged
* The tooth is not mobile

Exclusion Criteria:

* Children with bruxism or deep bite
* Children with especial need
* Presence of pathological root resorption in preoperative x-ray
* Presence of tooth wear (abrasion/attrition) on the opposing teeth