cyrilzakka/clinical-trials huggingface dataset:
The Effect of High-Volume Walking With Visual Cues (VC) in Parkinson´s Disease (PD)

People with disease (PD) tend to walk with short steps, decreased velocity, and increased stride time variability. Short steps and increased variability are related to greater fall risk. In addition, concurrent performance of a cognitive task (dual-task (DT)) has marked effects on gait in people with PD which is considered to reflect an impaired automaticity of gait.

Objective: To investigate short and long term effects of high-volume walking with visual spatial cues (VSC) on gait variables, automaticity, and functional mobility, in people with Parkinson´s Disease (PD), compared with walking without VSC.


Eligibility Criteria:
Inclusion Criteria:

* a confirmed diagnosis of PD according to the UK Parkinson´s Disease Society Brain Bank Clinical Diagnostic Criteria (18)
* \<80 years of age
* community residing
* Hoehn and Yahr (HY) stage 2-3
* Mini Mental State Examination (MMSE) score of \>23
* ability to walk without walking aids for a total of 20 minutes over a 30-minute period

Exclusion Criteria:

* major modifications of Parkinson´s medication (Madopar \>200 mg/d or \>20% increase in Dopamine agonists) 3 weeks prior to baseline assessment
* comorbidities or disabilities, which might influence walking
* a history of brain surgery
Ankle Sprain Rehabilitation With the Wii Balance Board

Physical activity and in particular sport is beneficial to health. Nevertheless, some of these activities may create a risk of injury. Ankle sprain is the most common sport related injury. Sports that are causing the highest number of ankle sprains are: football (30%), handball-basketball-volleyball-rugby (24%), gymnastics sports (6%), skiing (6%), cycling (6%), athletics (4%) and contact sports (4%). A recent study in the Netherlands identified a total of 1.3 million sports injuries. 47% of these patients required medical care. The total costs (direct and indirect) were assessed 84.240.000 EUR per year.

Prospective studies demonstrated that athletes with a ankle sprain have a twofold risk of re-injury during the first year after the trauma, and in half of patients with an ankle sprain recurrence this could lead to instability or chronic pain of the ankle.

The Wii Balance Board ® is a tool that is increasingly used in the field of health. In some hospitals, therapists are beginning to use it for the rehabilitation of patients after surgery, fractures or strokes.

Patients are asked to complete their physical therapy session by practicing "sports" via video games such as skiing, bowling or hula hoop. Currently, there are no randomized controlled studies that publish on the effectiveness of this tool. Recently, a study investigated the efficacy of the Wii Balance Board ® to improve balance, strength, joint mobility and level of physical activity. After 10 weeks of training, people an increased strength and balance was found. However, these results still require statistical confirmation. Thus this objectives of this study are

* To assess the efficacy of exercise training with the Wii Balance Board ® Platform
* To evaluate the effectiveness of physical therapy (based on current guidelines)
* To compare these two types of care (conventional physiotherapy versus Wii) to a control group (non-treatment).


Eligibility Criteria:
Inclusion Criteria:

* Patients with an ankle sprain (grad 1 or 2), between 18 and 65 years old,

Exclusion Criteria:

* The subjects will not be included in the study if they are under 18 years
* They have other neurological or orthopedic disorders
* If taking medications (other than analgesics +/- NSAIDs prescribed during a sprain) that may influence the measurements.
* The patients with recurrent sprain of the ankle which was less than 12 months or who require surgery were also excluded.
Comparison Between Hemitrapeziectomy and Total Trapeziectomy With Ligament Reconstruction and Tendon Interposition in Trapeziometacarpal Osteoarthritis II-III Eaton-Littler

1. Introduction:

   Investigators think that surgery with preservation of healthy joints (hemitrapeziectomy) in trapeziometacarpal osteoarthritis without affecting sapho-trapezo-trapezoid joints, is better for scaphoid stability by preventing its collapse and thus preserving the stability of the carpus.
2. Objectives and Hypothesis:

   Ligamentoplasty with partial trapeziectomy in grades II-III Eaton presents better results in the pollicis-lateral pinch (key pinch) strength than ligamentoplasty with total trapeziectomy.

   Main Objective:

   To demonstrate using the dynamometer that the postoperative key pinch strength higher using ligamentoplasty with partial trapeziectomy in grades II-III Eaton.

   Secondary objectives:

   To measure the collapse of the first column of thumb using calibrated radiographic analysis. Pain (E.V.A Scale). Range of motion (measured with goniometer). Quality of life (DISABILITIES OF THE ARM, SHOULDER AND HAND questionnaire).
3. Methodology:

It is a single-center randomized trial, parallel-group, in which two types of surgical techniques (TT - TP) will be compared. Patients will be randomized in this two techniques will be followed for one year, in routine clinical practice.


Eligibility Criteria:
Inclusion Criteria:

* Patients with Osteoarthritis in the trapeziometacarpal joint determined by the classification of Eaton-Littler (stages II-III) with trapeziometacarpal joint pain, loss of function, that were included in surgical waiting list and have accepted under informed consent, including the study.

Exclusion Criteria:

* Patients with osteoarthritis Eaton-Littler (stage IV).
* Patients with huge affection of trapezium subchondral cysts and poor quality of trabecular bone.
* Cognitive impairment.
* Old fracture with impairment of the same extremity.
* Rheumatic active illness.
* Patients who withdraw their informed consent, or in case of impossibility of opinion by clinical status, whose legal guardians or close relatives to withdraw their informed consent to participate in the study.
* Patients who for any reason not related to the indication needed discontinue study participation or impossible to carry out assessments under more than two follow-up visits.
* Patients in whom it is considered that participation in the clinical study can be a prejudice, the physician responsible for patient care opinion.
Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples

The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.


Eligibility Criteria:
Inclusion Criteria:

* type 2 diabetic patients
* prediabetic patients
* women with gestational diabetes
* healthy control subjects without diabetes
* healthy pregnant women

Exclusion Criteria:

* cancer disease
* infectious diseases such as hepatitis or HIV
* malignoms
* patients with claustrophoby
A Study to Assess Adverse Events and Change in Disease State in Adult Participants Being Treated With Humira in Participants Diagnosed With Pyoderma Gangrenosum (PG)

Pyoderma Gangrenosum (PG) is a rapidly progressive disease and presents as painful, single or multiple lesions, with several clinical variants, in different locations, with a nonspecific histology, which makes the diagnosis challenging and often delayed. The main objective of this study is to estimate the incidence proportion of all the infection reported as adverse drug reaction (ADR) of Humira with PG participants.

Humira is the only drug approved for the treatment of Pyoderma Gangrenosum (PG) in Japan. Approximately 60 adult participants with PG at approximately 60 sites in Japan.

Participants will receive injectable Humira (Adalimumab) as prescribed by the physician prior to enrolling in this study.

There may be a higher burden for participants in this study compared to standard of care. Participants will attend regular visits per routine clinical practice. The effect of the treatment will be checked by medical assessments, checking for side effects, and by verbal interview.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with Pyoderma Gangrenosum (PG).
* Have been prescribed Humira for PG treatment within 14 days.

Exclusion Criteria:

- Have Pyoderma Gangrenosum (PG) in previous treatment with Humira.
PCR Techniques of Dried Sputum Using a Spotcard

Molecular testing for mutations in M. tuberculosis genes associated to resistance of anti tuberculosis (TB) drugs is already part of standard laboratory TB diagnostic.

This implicates earlier knowledge of possible resistance and thus prevents unnecessary treatment and the chance of treatment failure or treatment related toxicity.

The molecular laboratory diagnostics is widely spread in high income, low TB endemic countries. However, the low income countries lack widespread facilities to test for susceptibility, either genotypic or phenotypic. Performing molecular diagnostics on sputum collected with a spot card could improve accessibility to molecular testing.

This study examines if sputum collected and put on spot cards could be used for multiple molecular tests for the detection, identification and susceptibility prediction of TB. This means that DNA extraction of the sputum from the spot card should be feasible.

The study is a pilot study with adult patients of the tuberculosis department of University Medical Centre Groningen (UMCG) Beatrixoord, Haren as subjects. The sputum produced will be collected, dried on spot cards, and DNA extraction from the card will be tested. If molecular detection is positive for the tuberculosis bacteria additional tests will be performed. Based on the present/absent of mutations in the genes associated to resistance susceptibility can be preditec, different molecular techniques will be performed to identify possible mutations. Furthermore, sputum will be collected as patients produce so. Sputum samples with low bacterial load can be tested as well and can test the sensitivity of the procedure.

Lastly, techniques like RNA detection will be tested to identify the bacterial load. This can be done if more than one sample of patients were collected.

Subjects will be selected on age, participation in standard TDM and drug use. Demographic parameters will be analysed. Sputum samples will be taken twice a week (on Tuesday and Friday).


Eligibility Criteria:
Inclusion Criteria:

* Patients is 18 years or older
* Pulmonary TB confirmed by culture or molecular test
* Producing sputum
* Signed informed consent

Exclusion Criteria:

* Extrapulmonary TB
* Pulmonary TB without production of sputum
Influence of Kinetic Chain Training on the Treatment Outcome of Overhead Athletes With Impingement

A randomized controlled trial will be conducted to examine the effectiveness of a traditional home exercise program versus 2 kinetic chain home exercise programs on treatment outcome of overhead athletes with shoulder impingement syndrome. Primary outcome measures are reduction of pain and disability, and improvement in functionality and sports performance. Secondary outcome measures are strength, mobility, flexibility and functional performance.

Participant are randomly assigned in 3 home exercise groups.

1. The traditional program: consists of solely strengthening the rotator cuff muscles and scapular muscles (e.g. external rotation)
2. Separate kinetic chain program: same exercises as the first group but they also receive an exercise program to separately train the core and lower body. (e.g. external rotation separately and squat separately)
3. Integrated kinetic chain program: same exercises as the first group but all exercises are performed while simultaneously activating the kinetic chain. (e.g. external rotation while squatting).

Eligibility Criteria:
Inclusion Criteria:

* Symptoms of shoulder impingement on the dominant side for at least 3 months and at least 3 of the following tests are considered positive

  * Jobe
  * Hawkins
  * Neer
  * Painful arc during elevation
  * Pain or lack of force production with isometric external rotation
  * Apprehension test
  * Relocation test
* Performing overhead sports at least 3 hours/week
* Shoulder pain interferes with sports activities
* They have not had treatment for this shoulder pain

Exclusion Criteria:

* History of shoulder dislocation or subluxation
* History of orthopedic surgery
* No complaints of pain or dysfunction in the upper limb (except impingement related complaints in the dominant shoulder), lower limb or spine at the last 6 months
* Currently taking nonsteroidal anti-inflammatory medication
* Received a steroid injection in the past 12 months
* Participating in another study
* Known systemic diseases
* Known structural diseases
Exercise Perceptions and Preferences Among Rheumatoid Arthritis Patients

The purpose of the study is to analyse exercise behaviour of rheumatoid arthritis patients.


Eligibility Criteria:
Inclusion Criteria:

* Rheumatoid arthritis
* Age 30 to 80 years

Exclusion Criteria:

* Language difficulties and no help from family members or friends
The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes

The present study evaluates skin microvascular reactivity and coronary physiology in the same coronary artery disease (CAD) patients.

This study is expected to find associations between systemic microvascular reactivity, measured non-invasively at the skin surface, and coronary reserve evaluated by the invasive angiographic method.

Introduction: Microvascular reactivity (MR) evaluated in the skin has been proposed as representative of systemic endothelial function, including coronary circulation. There is a lack of studies investigating the association between skin MR and invasive evaluation of coronary reserve. Objective: To evaluate skin MR and coronary physiology in the same coronary artery disease (CAD) patients. Methods: Transversal study, recruiting adult patients with indication for elective coronary angiographic study for the evaluation of CAD by an independent medical team. The evaluation of microvascular cutaneous blood flow of the forearm will use laser speckle contrast imaging (LSCI) coupled with acetylcholine iontophoresis. Coronary physiology will be evaluated in the same patients and in the same day with coronary angiography with lesion assessment by fractional flow reserve (FFR, after intracoronary adenosine administration) and contrast fractional flow reserve (cFFR, after intracoronary contrast media administration), with measurements of hyperemic intravascular pressures. FFR and cFFR will be performed in vessels with intermediate lesions, as evaluated in quantitative angiography. Expected results: This study is expected to find associations between systemic MR, measured non-invasively at the skin surface, and coronary reserve evaluated by the invasive angiographic method.

Eligibility Criteria:
Inclusion Criteria:

* Patients with intermediate obstructive coronary artery disease (40-80% lumen obstruction of epicardial vessels or 30-60% obstruction of left main coronary artery).

Exclusion Criteria:

* ST elevation myocardial infarction in the first 72 hours of evolution.
* Allergy to contrast media or adenosine
* Asthma or chronic obstructive pulmonary artery disease diagnosis
* Ongoing acute coronary syndrome
* Systolic blood pressure under 90mmHg
* Baseline arrhythmias or advanced atrioventricular blockade
* Advanced arterial calcification
* Renal failure (defined as serum creatinine above 1.5mg/dl)
* Saphenous graft or mammary artery graft anastomosis stenosis
* Severe left ventricular systolic dysfunction.
The Effect of Sympathetic Dysfunction on Muscle Spindle in Fibromyalgia

This study aims to reveal whether there is an impairment in the sympathetic regulation of muscle spindle sensitivity in patients with fibromyalgia syndrome (FMS).

The common muscle pain and fatigue symptoms of FMS can be explained by impaired sympathetic regulation of muscle spindle sensitivity. The aim of this study is to reveal whether there is an impairment in the sympathetic regulation of muscle spindle sensitivity in FMS patients.

Material method:

In the first stage, resting sympathetic tone measurement and resting H-reflex and T-reflex recordings will be taken in all cases. Sympathetic tone measurement will be performed and H-reflex and T-reflex recordings will be taken during and after sympathetic stimulation maneuvers (mental arithmetic calculation and cold application) in FMS patients and healthy control subjects. In the second phase, the first dose of pregabalin will be given to patients diagnosed with FMS and prescribed pregabalin. Pregabalin is known to reduce sympathetic activity in FMS. After oral administration of pregabalin, its peak plasma concentration is reached in 0.9-1.3 hours. Therefore, 1.5 hours later, sympathetic tone measurement will be made at rest and during the sympathetic stimulation maneuver, and H-reflex and T-reflex recordings will be taken. Patients in the healthy control group will not be given pregabalin.

Eligibility Criteria:
Inclusion Criteria:

For the fibromyalgia group

* Patients diagnosed with FMS based on the American college of rheumatology - 2016 criteria
* Between the ages of 20-50
* Being a woman
* Patients prescribed pregabalin for the treatment

For the Healthy Control group

* Between the ages of 20-50
* Being a woman
* Being healthy

Exclusion Criteria:

* Those with medical problems in the right upper and lower extremities (skin, neuromuscular, joint, vascular pathologies)
* Cases that cannot perform arithmetic operations
* Cold allergy
* Heart disease (arrhythmia, ischemic heart disease, heart failure)
* Hypertension
* Epilepsy
Bandebereho Father Groups Randomized Control Trial in Rwanda

This study seeks to assess the impact of the MenCare+/Bandebereho fathers'/couples' group education intervention on men's attitudes towards, and participation in, sexual and reproductive health, maternal, newborn and child health, and equitable and non-violent relationships with their children and partners.

This study seeks to assess the impact of the MenCare+/Bandebereho fathers'/couples' group education intervention on men's attitudes towards, and participation in, sexual and reproductive health, maternal, newborn and child health, and equitable and non-violent relationships with their children and partners. The MenCare+/ Bandebereho program is a multi-component comprehensive intervention being implemented by the Rwanda Men's Resource Center (RWAMREC) and Promundo-US, in collaboration with the Rwanda Ministry of Health and local authorities in Karongi, Musanze, Nyaruguru and Rwamagana districts. The proposed study will evaluate one component of the program, a 15-session group education intervention targeting young fathers and mothers. The impact of the fathers' group education will be assessed through a randomized control trial design with an intervention arm of men and women participating in the father groups and a control arm of men and women who do not participate in the intervention. The study will collect quantitative and qualitative data over a period of approximately three years.

Eligibility Criteria:
Inclusion Criteria:

* Men aged 21-35 years
* Living with a partner
* Expectant (or soon to be) father or father of young children under-5
* Living in an area with a group facilitator

Exclusion Criteria:

- Participated in previous cycles of the same intervention
Metabolomics Characterization of Biomarkers of Different Types of Myocardial Infarction in Different Time.

To find new biomarkers through Metabonomics Study of different types of myocardial infarction in Different Time.

In recent years, with the deepening understanding of the mechanism of myocardial infarction, in addition to the early understanding of plaque rupture, plaque erosion and other mechanisms, studies have found that inflammation, immunity, metabolism and other factors also play an increasingly important role in the occurrence and development of myocardial infarction. The LoDoCo2 study published at the 2020 ESC annual meeting and the COLCOT study previously published confirmed for the first time the therapeutic effect of anti-inflammatory drug colchicine in chronic coronary disease and acute myocardial infarction. At the same time, the fourth international definition of myocardial infarction also defines three different types of acute ST segment elevation myocardial infarction (STEMI), acute non ST segment elevation myocardial infarction (NSTEMI) and non infarct acute myocardial infarction (MINOCA). However, there are no clear research results on the mechanism, especially the mechanism of MINOCA. Therefore, the study of acute myocardial infarction in three groups is of great significance.

Eligibility Criteria:
Inclusion Criteria:

1.The patient clearly had acute myocardial infarction. 2.The patient's serum cardiac markers (mainly troponin) were elevated (at least above the upper limit of 99% reference value) and accompanied by one of the following clinical indicators：

1. Ischemic symptoms
2. New ischemic ECG changes, new ST-T changes or left bundle branch block（LBBB）.
3. Pathological Q wave formation in ECG
4. Imaging evidence showed new loss of myocardial activity or new regional wall motion abnormalities.
5. The thrombus was confirmed by coronary angiography. 3．The patient had chest pain symptoms, but coronary angiography showed normal coronary artery (such as intercostal neuralgia, cervical spondylosis, chest pain of unknown origin, etc.)

Exclusion Criteria:

1. Refusal to sign informed consent.
2. Surgical treatment was performed in the last three months.
3. Patients with a history of the following diseases or consider the diagnosis of the following diseases：Stress cardiomyopathy, myocarditis, pericarditis, pneumonia, pulmonary embolism, aortic dissection.
4. Severe heart failure, grade IV cardiac function.
5. Liver and kidney dysfunction.
6. blood-borne diseases, including HIV / AIDS, hepatitis B, hepatitis C, etc.
7. Patients with a history of malignancies, autoimmune diseases, severe infectious diseases and trauma.
8. Previous history of myocardial infarction and stroke.
Study on Music Intervention of Non-clinical College Students

The purpose of this trial is to understand whether a mindfulness-integrated volleyball team sports program can effectively intervene in the mental health of college students. The main questions it aims to answer is:

Does the music group effectively intervene in the participants' mental health levels, including indicators such as anxiety and depression?

Participants will:

Attend a music group once a week for 1.5 hours each session, for a total of 6 weeks.

Complete a psychological questionnaire every 3 weeks and a follow-up questionnaire every 2 weeks after the program concludes for twice.


Eligibility Criteria:
Inclusion Criteria:

* Participants aged 16 years or older.
* Able to communicate in Mandarin and voluntarily participate in the study.
* Agree to consistently participate in each session.

Exclusion Criteria:

* Disagree to consistently participate in each mindfulness-integrated volleyball course.
* Individuals unable to commit to participating in each mindfulness-integrated volleyball course.