cyrilzakka/clinical-trials huggingface dataset:
Mobile Education for Emergency Ultrasound

The investigators aim to investigate the feasibility of using mobile application platform for sonographic education.

Junior physicians at the National Taiwan University Hospital will be enrolled in this study. To design and develop a secure mobile application platform (consisting of mobile device and a cloud-based server) for interactive teaching, remote social-based consultation and discussion. The information exchange through the platform carries images and simulated cases.

This pioneer study can provide experience of mobile sonographic education and contribute to current medical education. Moreover, it can improve decision-making process and quality of care, and could lessen crowdedness at emergency departments. Furthermore, the integrated platform can be used in other educational programs in the future.

As usual, it takes time for junior emergency physicians to have good diagnostic accuracy through traditional sonographic education. Applying the technology built in this project, junior emergency physicians will be provided with intelligent learning programs anywhere and anytime.

Junior physicians at the National Taiwan University Hospital will be enrolled in this study.

Eligibility Criteria:
Inclusion criteria:

The junior physicians of the department of emergency medicine of the National Taiwan University Hospital.

Exclusion criteria:

The junior physicians of the department of emergency medicine of the National Taiwan University Hospital, refused to enter the study.
Efficacy and Safety of LAS41003 in the Treatment of Inflammatory Tinea Pedis

The aim of this study is to determine the efficacy and safety of a topical application of the combinational cream LAS41003 compared to application of its mono-substances after once daily treatment in patients with inflammatory tinea pedis.


Eligibility Criteria:
Inclusion Criteria:

* presence of tinea pedis caused by dermatophytes on one or both feet, characterized by physician's global assessment score of 2 ("notable signs and symptoms exist") or 3 ("prominent signs and symptoms exist") at baseline;
* the physical examination must be without other disease findings unless the investigator considers an abnormality to be irrelevant to the outcome of the study;
* female volunteers of childbearing potential must either be surgically sterile (hysterectomy or tubal ligation) or agree to use a reliable method of contraception with a failure rate of less than 1 % per year when used consistently and correctly such as implants, injectables, combined oral contraceptives, some intra uterine devices \[IUDs\], sexual abstinence or vasectomized partner;
* patients must be willing and able to comply with the requirements of the trial protocol;
* written informed consent obtained.

Exclusion Criteria:

* patients with hyperkeratotic chronic plantar tinea pedis (moccasin type);
* receiving systemic therapy with cytotoxic or immunosuppressive drugs either concurrently or within 12 weeks before the baseline visit;
* oral antifungal therapies within three months before study entry (8 months for oral terbinafine), systemic antibiotic or corticosteroid treatment, topical corticosteroids within 30 days before study entry;
* patients with diabetes;
* patients with compromised circulation;
* evidence of drug or alcohol abuse;
* pregnancy or nursing;
* symptoms of a clinically significant illness that may influence the outcome of the study in the four weeks before the treatment phase and during the study;
* participation in the treatment phase of another clinical study within the last four weeks prior to the first administration of investigational drug in this study;
* known allergic reactions to components of the study preparations, hypersensitivity against cetylstearyl alcohol;
* treatment with systemic or locally acting medications which might counter or influence the study aim within two weeks before the treatment phase of the study (e.g. glucocorticosteroids);
An Emotional Regulation Brief Procedure (PbRE) for Fibromyalgia Using ICT's

The study aims is to test the efficacy of an emotional regulation procedure for fibromyalgia patients using Information and Communications Technologies (ICTs). This procedure is based in a task that implies exposition to emotional words. The principal hypothesis is that exposition will improve the clinical symptomatology because the procedure restore an adequate emotional regulation.

Previous studies have demonstrated that FM patients have difficulties to process emotional words when they are compared to normal subjects (Mercado et al., 2013). This dysfunctional emotion regulation could show attentional bias and it could be a way to increase FM symptomatology as pain, and fatigue (Duscheck et al., 2014).

The emotion generation and its regulation through an experimental task as reading words is a well stablished procedure (Lang, Bradley y Cuthbert, 1997). This paradigm has been shown efficacy in clinical context, to reduce anxiety in social phobia (Masia et al., 1999; Baños, Quero y Botella, 2008), generalized anxiety disorders (Fracalanza, Kroner y Antony, 2014), personality disorders (Arntz et al., 2012), and depression (Chuang et al., 2016). To address the gap between the experimental results of this form of emotional regulation in FM patients, and its clinical application, the aim of this study is to evaluate the efficacy of a Brief Procedure of Emotional Regulation for Fibromyalgia (PbRE)

PbRE is a word reading task implementing through an App developed for smartphones. The patient will choose emotional positive and negative words related to personal and clinical characteristics. This exercise has been shown useful in analogous tasks in relational frame theory (Hussey y Barnes-Holmes (2012) or in bias computer training (Salemink et al., 2014).

Eligibility Criteria:
Inclusion Criteria:

* Met the American College of Rheumatology (ACR) 2010 research classification criteria for FM (Wolfe et al., 2010, 2011); as confirmed by a rheumatologist
* A minimum of 18 years of age
* Showed adequate reading comprehension
* Were able to use a smartphone
* Were able to sign an informed consent form.

Exclusion Criteria:

* Had any mental disorder treated by a psychiatrist
* Were scheduled for surgery in the next 3 months.
Prospective, Observational Study of Low-risk Criteria for Node Metastasis in Endometrial Cancer

The purpose of this study is to evaluate the efficacy of low risk criteria for lymph node metastasis, that was determined by KGOG-2014 retrospective study, in women with endometrial cancer.

The Korean Gynecologic Oncology Group (KGOG) undertook a multi-center retrospective study to develop a preoperative prediction model for lymph node metastasis in endometrial cancer (KGOG-2014). This retrospective multi-center study showed that the accurate identification of a low-risk group for lymph node metastasis among the patients with endometrial cancer can be achieved with the new criteria using preoperative MRI and serum CA-125 assay. In this study, serum CA125 levels and three MRI parameters (deep myometrial invasion, lymph node enlargement, and extension beyond uterine corpus) were found to be independent risk factors for nodal metastasis. Based on the success of KGOG-2014, Korean Gynecologic Oncology Group initiated this prospective, multi-center observational study to validate our prior prediction model.

Eligibility Criteria:
Inclusion Criteria:

* Patients with a histologic diagnosis of endometrial cancer before surgical staging.
* Patients with a preoperative magnetic resonance imaging (MRI) and serum CA-125 within 4 weeks from surgical staging.
* Patients who underwent adequate systemic lymph node dissection during surgical staging.

Exclusion Criteria:

* Patients with a histologic feature suggesting sarcoma or squamous cell carcinoma
Peri-operative Prediction of Prolonged Stay in the Cardiac Intensive Care Unit for Adult Cardiac Surgery

The purpose of this study is to create a model using intra-operative modified SOFA score and peri-operative clinical factors to predict prolonged stay in the cardiac intensive care unit (CICU) for adult cardiac surgery with heart-lung machine

Cardiac surgery using cardiopulmonary bypass (CPB) is commonly associated with a systemic inflammatory response that exacerbates peri-operative life-threatening complications and multiple organ dysfunction syndromes. These features can prolong the stay in the CICU. Many peri-operative clinical risk factors contribute to those adverse outcomes resulting in prolonged CICU stay. If the investigators can create a model to identify the effects of these intra-operative clinical risk factors to prolonged CICU stay

Eligibility Criteria:
Inclusion Criteria:

* adult patients who had undergone elective cardiac surgery with CPB

Exclusion Criteria:

* under 18 years of age
* needing emergency surgery
* needing intra-aortic balloon pump
Effect of Pneumoperitoneum on the Continuous and Non-invasive Hemoglobin Monitoring

The primary purpose of this study is to investigate the effect of pneumoperitoneum on the continuous and non-invasive hemoglobin monitoring during laparoscopic gastrectomy


Eligibility Criteria:
Inclusion Criteria:

* Laparoscopic gastrectomy under general anesthesia

Exclusion Criteria:

* atypical hemoglobin disease, infective state, cardiovascular disease, peripheral vascular disease
Compensatory Strategies Applied to Cognitive Impairment in Schizophrenia

The purpose of this study is to determine whether Cognitive Adaptation Training are effective in comparison with conventional treatment, focusing on social functions, symptoms, relapse, re-hospitalisation, and quality of life in outpatients with schizophrenia.

It is estimated that approximately 80% of patients with schizophrenia have reduced cognitive functions, representing problems with attention, verbal memory, short-term memory and executive functions (1-3). These impairments might have an impact on the patients ability to complete rehabilitation programmes, apply learned strategies to social problems, develop work skills and manage daily life (4,5). The effect of Cognitive Adaptation Training has been tested as a psychosocial treatment including training of compensatory strategies in order to sequence patient's adaptive behaviour, showing promising results concerning improved social functions (6). There are however no solid evidence for these statements. The existing few studies investigating the effect of Cognitive Adaptation Training (6-8) are underpowered (small sample sizes) and have a lack of younger patients, which limits the conclusions that can be drawn from the results of the improvement. The present trial employs a prospective design of 26 weeks with a follow-up period of 9 months after inclusion. The study will enroll 164 consecutively recruited participants from three Danish out-patient teams for young adults with a first episode of psychosis.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of schizophrenia.
* More than one year from referral to the psychiatric clinic.
* Receive mental medication and continual psychosocial treatment.
* Participants who have signed informed consent.

Exclusion Criteria:

* Participants who don't understand or speak Danish.
* Participants who live at an institution or who are long-term hospitalized.
* Participants who are unwillingly to complete protocol.
The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction

The purpose of this study is to evaluate the response of a treatment with testosterone undecanoate and determine the levels of total and free testosterone in hypogonadal patients with erectile dysfunction.

Hypogonadism is a pathophysiologic and clinical factor in a substantial number of patients with ED,and data indicate that a threshold level of testosterone is necessary for normal erectile function.Testosterone therapy is clearly indicated in hypogonadal patients and is beneficial in other patients with ED and hypogonadism.However,testosterone efficacy as monotherapy for ED could be limited,and combination therapy with testosterone and other ED treatments,such as PDE-5 inhibitors may be valuable in certain subpopulations of patients.

Eligibility Criteria:
Inclusion Criteria:

1. Patients with ED over 3 months (specify using IIEF score)
2. Age \>= 18 years.
3. Stable sexual relationship
4. With low or low normal serum testosterone level (either total or bioavailable testosterone) TT \<= 4 ng/ml and/or BT \<= 1 ng/ml
5. Aging Male Symptom scale with total score starting at 37 points (must not replace TT \< 4 ng/ml)
6. Eligible subjects who previously took the oral androgen or PDE5 inhibitor must have discontinued their use for 1 month

Exclusion Criteria:

1. Contraindication to treatment with Testosterone according to the SPC
2. Hypersensitivity to the active substances or any of the excipients of Nebido
3. Diagnosed or suspected carcinoma of the prostate or the male breast cancer
4. Past or present liver tumors
5. Acute or chronic hepatic diseases
6. Severe cardiac, hepatic or renal insufficiency
7. History of penile implant or significant penile deformity
8. Diagnosed sleep apnea
9. Polycythemia (Hematocrit \>50%)
10. Prolactin \>25 ng/ml
11. Organic hypothalamic-pituitary pathology
12. Any unstable medical, psychiatric or drug/alcohol abuse disorder
13. Prostate specific antigen (PSA)\>= 4 ng/ml
14. Severe symptomatic benign prostatic hyperplasia (IPSS) sum score \>=20)
15. Diabetes mellitus which is uncontrolled (HbAlc level \>10%)
16. Epilepsy not adequately controlled by treatment
17. Patients requiring fertility treatment
18. Hypertension which is not adequately controlled on therapy
19. Clinically significant chronic hematological disease which may lead to priapism such as sickle cell anemia, multiple myeloma or leukemia
20. Hypersensitivity to PDE-5 inhibitors
21. Concomitant Medication:

    * Nitrites or Nitric oxide donors
    * Anti-androgens
    * anti-coagulants, with the exception of anti-platelet agents
    * Any of potent inhibitors of cytochrome P-450 3A4:such as HIV protease inhibitors (Ritonavir or Indinavir); Anti-mycotic agent (Itraconazole and Ketoconazole)-topical application allowed; or Erythromycin.
TD-1473 Long-Term Safety (LTS) Ulcerative Colitis (UC) Study

A 3-Year Multi-Center, Long-Term Safety (LTS) Study to Evaluate the Safety and Tolerability of TD-1473 in Subjects with Ulcerative Colitis who have participated in the Maintenance Study of Protocol 0157

This is a multi-center, long-term safety study to evaluate the safety and tolerability of TD-1473 for up to 156 weeks (3 years) + 4 week follow-up in subjects with moderate to severe UC exiting the preceding Maintenance Study of Protocol 0157 (NCT03758443).

Eligibility Criteria:
Inclusion Criteria:

To be eligible for the study, subjects are required to enter the LTS Study within 14 days of exiting the Maintenance Study of Protocol 0157 and must meet all the following criteria:

* Capable of providing informed consent, which must be obtained prior to any study related procedures.
* One of the following:

  * Those who demonstrated persistent loss of response (no improvement 8 weeks after meeting loss of response criteria) OR
  * Two Clinical Flares after an episode of loss of response during the Maintenance Study OR
  * Those who have completed the Maintenance Study and confirmation of clinical remission status results are available
* During the study and for 7 days after receiving the last dose of the study drug, females of childbearing potential or men capable of fathering children must agree to use highly effective birth control measures (failure rate \<1% when used consistently and correctly)) or agree to abstain from sexual intercourse. Females of childbearing potential must test negative for pregnancy at Day 1
* All male subjects must agree to refrain from semen donation during the study and for 7 days after the last dose of study drug.
* Must be able and willing to adhere to the study visit schedule and comply with other study requirements.

Exclusion Criteria:

* Has symptoms suggestive of fulminant colitis, megacolon or intestinal perforation
* Likely to require surgery for UC or other major surgeries
* Has previously received / is currently receiving prohibited medications
* Has been diagnosed during Protocol 0157 with Crohn's disease, other colitis conditions or the subject has a current or past diagnosis of a fistula or abdominal abscess
* Has endoscopic findings during Protocol 0157 of colitis-associated colonic dysplasia (with the exception of subjects with non-colitis associated spontaneous adenomas that have been completely resected)
* Has clinically significant abnormalities in laboratory evaluations
* Additional exclusion criteria apply
Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence

The purpose of this study is to determine patient satisfaction with LATISSE® treatment for increasing eyelash prominence.


Eligibility Criteria:
Inclusion Criteria:

* Have inadequate eyelashes
* Never used prescription eyelash growth products

Exclusion Criteria:

* No visible eyelashes
* Permanent eyeliner or eyelash implants
* Semi-permanent eyelash tint, dye, or extensions within 3 months
* Over-the-counter eyelash growth products within 6 months
* Any disease, infection or abnormality of the eye or area around the eye
* Eye surgery within 3 months, or the anticipated need for eye surgery during the study
* Unable or unwilling to keep contact lenses out during drug application and for 30 minutes after application
Doll Therapy for Agitated Elderly Dementia People

This study is designed to determine the effect of doll therapy on the levels of agitation, nutrition, and daily living activities in elderly patients with dementia and agitation.

Elderly patients with agitation and dementia incur significant costs for healthcare services. Additionally, it is known that agitation can impose a burden on caregivers and has the potential to cause harm to the individual and those around them. This study is planned to determine the effect of doll therapy on the levels of agitation, nutrition, and daily living activities in elderly patients with dementia and agitation.

Eligibility Criteria:
Inclusion Criteria:

* Patients with dementia
* be 65 years of age or older
* having met the DSM-IV standard for dementia diagnosis
* having a moderate dementia diagnosis
* having a severe dementia diagnosis
* having enough manual skills to hold and care for the doll
* visual acuity is sufficient to recognize the doll
* there is no communication problem
* volunteered to participate in the research
* to have the consent of the relatives patients to participate in the research.

Exclusion Criteria:

* having a mild dementia diagnosis
* the presence of systemic disease in the period of acute exacerbation
* who has a psychological disorder
* elderly people who experienced difficulties after two attempts in accepting a baby and forming a relationship
* elderly people who left the doll after a while despite accepting it
* elderly people who stated that dolls have a bad connotation in themselves.
Respiration Rate Monitoring in COPD Patients

Assess the feasibility of using remote respiration rate monitoring as a component of home care, how respiration rate data may be used in combination with other data to potentially improve response to symptoms, and to generate data to inform the endpoints and effect sizes of future studies.

The research question is whether monitoring of respiration rates and variability can be helpful in management of COPD patients in conjunction with or separately from self-reported symptom scores using the COPD Co-PILOT application. Current techniques (such as patient's self-reported symptoms) have limited sensitivity and specificity with regard to predicting decompensation. Measurement of respiration parameters and the variability of the parameters may detect worsening COPD. Changes in respiration patterns may occur sufficiently far in advance of decompensation (e.g. \>5 days prior to patient symptoms) such that it would allow an opportunity for earlier intervention with medical assessment and current therapeutic approaches.

The specific primary aim includes evaluation of the correlation of respiration rate parameters to indicators of healthcare utilization including drug changes, office or ER visits, hospitalization, or other clinical interventions. Secondary aims include evaluation of (i) the sensitivity and specificity of respiration rate monitoring results to predict COPD worsening requiring medical intervention, (ii) the sensitivity and specificity of respiration rate monitoring results in conjunction with COPD Co-PILOT scores or components to predict COPD worsening requiring medical intervention, and the correlation of respiration rate parameters to episode duration as defined by number of days from COPD Co-PILOT Score \>1 to resolution (COPD Co-PILOT Score \<1 for 7 consecutive days).

Eligibility Criteria:
Inclusion Criteria:

* Males or females age ≥35 years old
* Documented diagnosis of moderate to very severe COPD (GOLD Level II-IV)
* Weight ≥35 kg
* Currently using the COPD Co-PILOT application (at least 3 months with 70% compliance)
* Must be able to read and understand English and consent for themselves

Exclusion Criteria:

* Currently using any form of non-invasive positive airway pressure ventilation
* Diagnosis of significant heart failure (NYHA Class III or IV)
* Cognitive impairment (determined by physician) that will make it hard to follow instructions regarding device usage
* BMI ≥45.5
* Residing in hospice care, Skilled Nursing Facilities or Long Term Acute Care facilities
* Currently using a wearable drug infusion pump to deliver medication
* Planned procedures at time of enrollment that will occur within timeframe of study and require hospitalization etc.
* Declines to participate at any time.
* In the opinion of the Investigator, may be non-compliant with study schedules or procedures
* No cellular coverage at their primary residence
Changing Opioid Users' Negative Attitudes Toward Medication Assisted Treatment

In this treatment development project, the investigators propose to develop and assess the feasibility and acceptability of a narrative-based video intervention and accompanying workbook (entitled MATTeRS: Medication Assisted Treatments: Telling Real Stories) designed to be used by people in inpatient opioid detoxification. Using the Health Belief Model as a framework, videos will provide information about the uses and outcomes of Medication Assisted Treatments (MATs) compared to other or no post-detoxification treatment through the use of narratives from real people's lives.


Eligibility Criteria:
Inclusion Criteria:

1. Currently undergoing inpatient opioid detoxification;
2. Qualify for use of one or more MATs;
3. Have health insurance;
4. Able to read and speak English;
5. Aged 18 or older;
6. No suicide ideation or behavior requiring immediate attention;
7. Live in the Rhode Island or Massachusetts area and have a working telephone;
8. Able to provide two contact persons to verify location and in case we are unable to reach the participant during the study;
9. Do not have probation/parole requirements that might interfere with protocol participation.