cyrilzakka/clinical-trials huggingface dataset:
Cell Phone Application to Help Adolescents and Young Adults in Their Therapeutic and Educational Journey

About 2000 cancers/year in France are diagnosed in Adolescents and Young Adults (15-25 years old, AYA). The cancer plans and the INCA recommend support during and after cancer, taking into account both medical and psychosocial specificities related to age (supportive care, school learning/training and professional integration, fertility preservation, therapeutic education, addictology, sexology...). The care offered is often heterogeneous for these AYAs in transition between the pediatric and adult worlds. They may be cared for either in pediatric oncology units or in adult structures. In this context, an AYA team has been developed in the Strasbourg center, led by a Nurse Coordinator (IDEC), social workers, psychologists and doctors. Thus, the young patients and their relatives are accompanied by professionals during their therapeutic care. In spite of this global care and closer to the patient, it is still necessary to find connected health tools for these AYA.

In this context, the Strasbourg team has initiated the development of a digital application compatible for any cell phone OnKO-Tips \&Tricks meeting these criteria of necessity. The application is currently in its final phase and requires validation by patients through a feasibility study that will last 6 months. Thus, all patients currently followed or newly diagnosed with liquid or solid cancer and aged between 15 and 25 years old will be included and will have the opportunity to test the application, its practicality as well as its current use and in particular its expected benefits for an optimization of our ETP program.

Eligibility Criteria:
Inclusion criteria:

* Subject whose age is ≥ 15 years and ≤ 25 years
* Subject diagnosed at the Strasbourg center (HUS and ICANS) with solid or liquid cancer
* Subject followed in the Strasbourg center (HUS and ICANS)
* Subject (or his/her legal representatives) having given his/her (their) agreement to participate in the evaluation survey of the OnKO-TnT digital application
* Subject agreeing to complete all satisfaction questionnaires
* The subject understands, speaks and writes French fluently
* Subject having a cell phone capable of downloading the application (developed for any type of cell phone)

Criteria for non-inclusion :

* Opposition of the subject (or the holders of parental authority) to participate in the satisfaction survey
* Subject under legal protection
* Subject under guardianship or curatorship
Non-interventional Study on Compliance of Inhaled Treatment With Ventavis in Patient With Pulmonary Hypertension

Local, prospective, multicenter, non-comparative, non-interventional, observational study. It is planed to assess compliance of patients with PH (pulmonary hypertension) with the physician's recommendation in real practice.


Eligibility Criteria:
Inclusion Criteria:

* Male and female patients ≥ 18 years old
* Diagnosis of PH
* Planned or current treatment with Ventavis (not more than 6 month)

Exclusion Criteria:

* Contraindications for the use of Ventavis in accordance with the local product information
Extension for Community Healthcare Outcomes Autism Replication Evaluation

ECHO Autism was intended to assess rigorously the impact of a 12-session telemedicine training program on participating Primary Care Providers (PCP) knowledge, clinical behavior, and self-efficacy in the screening and care of children with Autism Spectrum Disorder (ASD). Each session is referred to as an "ECHO clinic".

The study involved 10 sites (each referred to as an "ECHO Autism Hub"), each running a 12-session training program using a common curriculum and core lecture, with each site expected to recruit 15 PCPs. Sites were randomized in a stepped-wedge design with 5 clusters (2 sites per cluster) and a staggered start over a 1-year period. Staggering the start allowed for some control for potential temporal trends, as well as allowing the core team to focus on working with each site to ensure smooth startup of the training program at each site.

Outcomes are measured at baseline (Month 0), during the intervention (approximately 3 months after the start of the intervention) and after the end of the intervention (approximately 6 months after the start of the intervention). An additional measurement was made 3 months after the end of the intervention to assess whether deterioration occurs after clinic participation ends.

All participants received the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Current practice as a primary care provider (PCP)
* Currently providing care for children
* Professional training in: general pediatrics, family medicine, advance practice nursing (i.e. nurse practitioner or physician assistant)
* Active medical license in the state of practice
* Patient population is at least 50% underserved

Exclusion Criteria:

* Trainee status (e.g., medical student, intern, resident, or other pre-professional trainee)
* Subspecialist (e.g., psychiatrists, neurologists, developmental and behavioral pediatricians)
* Practicing within the same practice as another PCP participant (i.e., only one PCP participant from any given practice may be enrolled as a research participant in the study)
Retinal Vessel Diameter in Branch Retinal Vein Occlusion

The authors investigated the consecutive change of retinal vessel's diameter in affected eye and fellow eye of Branch Retinal Vein Occlusion.

Twenty five consecutive patients who had undergone intravitreal bevacizumab injection for Branch Retinal Vein Occlusion with macular edema were included in this study. All subjects were enrolled between April, 2012 and April, 2013 in the Department of Ophthalmology, Kyungpook National University Hospital.

Eligibility Criteria:
Inclusion Criteria:

* Best-corrected visual acuity less than 20/40
* Central subfield macular thickness (CSMT) 300 μm or greater on spectral-domain optical coherence tomography

Exclusion Criteria:

* Patients with recurrent BRVO
* History of previous treatments for BRVO including vitreoretinal surgery, intravitreal injection, subtenon injection or laser photocoagulation
* Patients with diabetes or dyslipidemia
* IOP ≥ 22mmHg, treatment for glaucoma, a family history of glaucoma, or optic neuropathy
* High myopia (\<-6 Diopters), high hyperopia (\>6 Diopters) or a history of refractive surgeries
* Co-existing retinal disease other than BRVO
* Corneal diseases include ulcer, keratoconus and a history of corneal laceration
* Cataract and other media opacities resulting in visual impairment or poor fundus images
NB-001 Treatment of Recurrent Herpes Labialis

This is a study to test the hypothesis that time to healing of a cold sore will be lower in the active treatment arm of the study when compared to the vehicle (placebo). Subjects with a history of cold sores will be enrolled and administered active treatment or placebo in a blinded manner. Subjects will then be followed to assess time to healing.


Eligibility Criteria:
Inclusion Criteria:

1. Be a healthy man or woman 18 years of age or older. Women who are pregnant, lactating or may become pregnant may (at the investigator's discretion) be included in the study;
2. Have recurrent herpes labialis as defined by a history of three (3) or more cold sore recurrences on the lips and/or skin surrounding the lips in the previous year. The majority of their cold sore recurrences proceeded by a well-defined history of prodromal symptoms including redness, pain, burning, tingling, itching, swelling or a tight sensation of the lip at the site of the outbreak;
3. Be willing to refrain from using systemic or topical antiviral agents or systemic corticosteroids within 4 weeks prior to study drug administration and for the duration of the cold sore recurrence;
4. Be willing to refrain from using any topical pharmaceutical or cosmetic products other than the study medication in or around the nasal and perioral areas for the duration of the cold sore recurrence;
5. Be willing to refrain from participation in another clinical trial;
6. Be willing and able to use phone or internet to obtain the combination to unlock their study medication kit;
7. Be able to read and write in English and understand and comply with the protocol requirements;
8. Be able to give informed consent and have signed a written informed consent form.

Exclusion Criteria:

1. Known hypersensitivity to one of the drug ingredients, including soybean oil, polysorbate (Tween), alcohol, EDTA, or cetylpyridinium chloride (found in some mouthwashes and lozenges);
2. Severe chronic illness including renal failure, severe respiratory or cardiac disease, chronic infections, immunodeficiency syndrome, uncontrolled diabetes mellitus or untreated severe thyroid disease;
3. Received (within the last 6 months) or receiving chemotherapy;
4. Significant skin disease on the face (such as atopic dermatitis, cystic acne, severe rosacea, eczema, psoriasis or other chronic vesiculobullous disorders) or lesions, wounds, abrasions, piercings, tattoos, irritation or other skin conditions on or around the nasal and perioral areas that would interfere with the treatment or assessment of the primary lesion complex. Subjects with mild controlled psoriasis, eczema, acne or dermatitis or other conditions may be included if the condition does not interfere with the ability to evaluate a herpes labialis lesion or local skin irritation;
5. Previously received herpes vaccine;
6. Active alcohol or drug abuse;
7. Prior randomization into any NanoBio study;
8. Any condition that would potentially make them unable to participate for the entire trial period;
9. Known allergies to topical creams, ointments or other topical medications.
Assessment of Motor Adaptation in Precision Grip Performance of Children

Preterm children usually suffer from mild hand motor performance, however, the problem are rarely detected in time. Identifying the pathology causing deficits in sensorimotor control of a hand helps the occupational therapist to determine appropriate clinical decision-making for intervention. Well-motor performance requires complete sensorimotor control. Understanding hand sensorimotor control mechanism and its neural control can help clinicians find the reason behind hand motor deficits. The analysis of motion adaptation of the precision pinch behavior in the perturbing environment has been regarded as a clinically meaningful tool for evaluating sensorimotor control of a hand, especially for the complex anatomical structure of bone and tendon. The motor adaptation analysis for the precision grip behavior can provide the temporal and spatial parameters of dynamic grip force adjustment. Therefore, the exploration of motor adjustment can provide in-depth understanding of the neural mechanisms that lead to impairment of motor function and skill acquisition of a child, which can assist clinical occupational therapist in identifying the cause and severity of impairment of children's hand skills and provide appropriate strategies and types of treatment. The recent research on children's motor adaptation focuses on the discussion of the efficiency of motor adaptation in unfamiliar or disturbing task situations. Thus, the first purpose of this research is to develop an easy-to-detect apparatus to detect the adjustment efficiency of a responsive grip behavior of children in a disturbing pinch-lifting task and to construct the reliability of its evaluation. The second purpose of the research is to understand the correlation between the efficiency of children's reactive pinch performance adjustment and the results of traditional evaluation of fine motor development scale and sensorimotor control assessments. The third purpose of the research is to analyze the difference in motor adjustment of a precision pinch performance at different ages of preschool children. The fourth purpose is to compare the efficiency of motor adaptation in preterm and term children. In addition, preterm birth is often accompanied by white matter abnormalities and affects future hand motor performance. Investigating white matter imaging markers for predicting motor adaptation can help early detection of problems. Therefore, the fifth objective was to explore whether specific white matter imaging markers can predict the efficiency of reactive motor adaptation.


Eligibility Criteria:
Inclusion Criteria:

1. Must be able to do reach-to-grasp performance
2. Intact comprehension ability

Exclusion Criteria:

1. Diagnosis of cerebral palsy and other genetic or congenital damage
2. Bone and nerve damage in the upper limbs in the past year
3. Un-correctable problems of vision or hearing impairment
Food Safety Educational Training Program to Improve Food Safety Knowledge and Behaviors in Cancer Patients Receiving Treatment

This clinical trial evaluates the impact of a food safety educational training program on food safety knowledge and behaviors in cancer patients receiving treatment. Cancer treatments, such as chemotherapy, can put patients at risk for foodborne infections and despite this risk, it has been reported that patients do not receive any food safety counseling until they are already experiencing low white blood cell counts. A food safety educational training program may help cancer patients make better choices of low-risk foods and prepare foods safely.

PRIMARY OBJECTIVE:

I. Evaluate the efficacy of a food safety education intervention for cancer patients.

OUTLINE:

Patients attend a food safety educational training program over 50 minutes on study.

After completion of study intervention, patients are followed up at 5 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Participants must be at least 18 years of age
* Able to fluently read and converse in English (though it does not have to be their first language)
* All participants must be diagnosed with cancer, any stage, and be receiving some form of treatment at the aforementioned facilities
* Informed consent must be obtained from each patient prior to participation in any aspect of the study

Exclusion Criteria:

* Patients who do not meet these criteria or are not willing or are unable to give informed consent, will be excluded from this study
* Patients with prescribed dietary limitations or currently on neutropenic diet unrelated to this study will not be included
The Effect Of Cervical Muscle Fatigue in Neck Proprioception and Postural Stability

PURPOSE:

To investigate the effect of cervical muscle Fatigue on neck proprioception and postural stability during cervical flexion.

BACKGROUND:

Postural stability is the ability to maintain the body in equilibrium either at rest or in a steady state of motion . Muscle fatigue is the diminished response of muscle to repeated stimulus. Cervical proprioceptive inputs provide important somatosensory information influencing postural stability. Hence, the investigators performed this study to evaluate the effect of experimentally induced fatigue on general cervical musculature on postural stability .

HYPOTHESES:

This study will hypnotize that:

1. Cervical flexor muscle fatigue will have a significant effect on neck proprioception
2. Cervical muscle fatigue will have a significant effect on posture stability

RESEARCH QUESTION:

Will fatigue of cervical flexors have an effect on neck proprioception and postural stability?

the research methodology that will be used

Induction of fatigue using isometric neck flexor muscle endurance test (NET):

An isometric neck muscle endurance test (NME test) will be performed for the deep neck flexors (Rectus Capitus Anterior, Rectus Capitus Lateralis, Longus Capitus, Longus Colli) until exhaustion in all participants occurs. With the subject in hook lying position through CHIN RETRACTION AND HEAD ELEVATED FROM THE COUCH.

All the assessment measurements will be done before and just immediately after performing the cervical muscle fatigue then after 15 minutes of fatigue induction(fatigue recovery) A. Measurement of neck proprioception using cervical joint position error test via OVERHEAD LASER POINTER

B. Measurement of postural stability using :

1. Biodex balance system(limit of stability) to measure postural stability
2. Multi-Directional Reach Test

Eligibility Criteria:
Inclusion Criteria:

* having cervical range of motion 80 to 90 of flextion, 70 degree of extension, 20 to 45 degrees if lateral flextion, and 80 to 90 rotation to both sides.
* having normaluscle test strength for cervical neck flexors according to group manual muscle test
* body mass index ranging from 18.5 to 24.9 kg/m2

Exclusion Criteria:

* any history of pathological truma to the cervical,thoracic or lumbar spine, upper extremity or rib cage.
* surgical condition of the spine
* having any orthopedic, musculoskeletal or neurological disorders around cervical region.
* any vestibular impairment (e.g.vertigo)
* spinal postural deformities as hyper kyphosis \&scoliosis
WEMR With Clinical Decision Support for All Wounds

The goal of this project to begin using a wound research database with clinical decision support features at Winthrop University Hospital. A research database is an electronic computer system that is used to collect patient information. Clinical decision support is the ability for a computer system to provide medical assistance to the doctor through alerts and recommendations based on the information entered. The investigators believe that use of a wound clinical decision support tool, much like a drug, will improve healing in patients with chronic wounds (wounds that fail to heal over the course of weeks) and ultimately lower the risk of death and illness caused by these wounds. In order to develop a useful clinical decision support tool, investigators first need to develop a large research database to determine the data points important for wound healing. The investigators will be using the data collected in this study for future research and publication. Data will be reviewed to answer questions important to wound healing and for the purpose of developing the clinical decision support alert system.

After providing informed consent, participants will be asked a series of questions related to their past medical history, and relevant wound data will be collected. Study staff will photograph the wound at baseline, and once per week until the wound is completely healed, or for a duration of six months.

Participants will be expected to return to Winthrop University Hospital for wound follow-up on a regular basis, or as determined by the Principal Investigator.


Eligibility Criteria:
Inclusion Criteria:

* 21 years or older
* Diagnosed with a wound (defined as a break in the integument)
* Must be willing and able to provide written informed consent

Exclusion Criteria:

* Patients with Diabetic Foot Ulcers
Eliquis Safety Surveillance in Japanese Patients With NonValvular Atrial Fibrillation

The primary objectives of this study are:

* To estimate the incidence rate of unexpected adverse events
* To characterize the bleeding events and assess risk factors of bleeding
* To identify ancillary baseline variables that may also be associated with adverse outcomes


Eligibility Criteria:
For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com.

Inclusion Criteria:

* Patients who are beginning to receive the treatment with this product under the approved indications, dosage, and administration will be included in this study

Exclusion Criteria:

* Patients who are receiving Eliquis outside of its approved indication will be excluded from this study
Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial

The aim of this study is to evaluate the feasibility to perform a future larger clinical trial to analyze whether the mechanical ventilation reconnection for 1 hour after a successful spontaneous breathing trial reduces the risk of reintubation or death at 7 days in participants with more than 72 hours of mechanical ventilation. The study will compare two weaning strategies in critically ill participants admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial:

1. Reconnection to mechanical ventilation for 1 hour followed by extubation;
2. Direct extubation.

Follow-up will be until hospital discharge or death.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years;
* Admission to the intensive care unit;
* Orotracheal intubation;
* Mechanical ventilation for more than 72 hours;
* Spontaneous breathing trial (according to the study protocol) successful and considered able to be extubated.

Exclusion Criteria:

* Patients unable to obey commands;
* Unplanned extubation;
* Neuromuscular disease and cervical spinal cord injury;
* Tracheostomy;
* Contraindication for cardiopulmonary resuscitation or reintubation;
* Absence of informed consent.
Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions

The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with a brain metastasis or primary brain tumour and who will undergo MRI with contrast.

Exclusion Criteria:

* Subject or subject's legally authorized representative is unable or unwilling to consent to the study.
* Subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.
Comparisons of Two Types of Robot Assisted Gait Training

Comparisons of Two Types of Robot Assisted Gait Training: Exoskeleton Type Robot vs. End-effector Type Robot: Randomized Controlled Trial


Eligibility Criteria:
Inclusion Criteria:

* Hemiplegic patients secondary to first cerebrovascular accidents
* Ankle dorsiflexor strength: medical research council scale 2 or 3
* Functional ambulation category score 3

Exclusion Criteria:

* History of surgery of affected lower limb
* Fracture of affected lower limb