cyrilzakka/clinical-trials huggingface dataset:
The Effect of BMI on Gluteus Maximum Activity in Adulthood With Sacroiliac Dysfunction

PURPOSE:

This study will be conducted to investigate the effect of BMI on gluteus maximum activity in adulthood with sacroiliac dysfunction BACKGROUND: Sacroiliac joint (SIJ) pain is pain arising from SIJ structures and SIJ dysfunction (SIJD) generally refers to aberrant position or movement of SIJ structures . An estimated 15-30% of all low back pain cases are due to SIJ pain The present study will be conducted to add a new information to the body of knowledge of physical therapy profession as it will investigate the effect of BMI on gluteus maximum activity in adulthood with sacroiliac dysfunction

HYPOTHESES:

. •There will be no effect of BMI on gluteus maximum activity in adulthood with sacroiliac dysfunction

RESEARCH QUESTION:

* Do BMI has an effect on gluteus maximum activity in adulthood with sacroiliac dysfunction?


Eligibility Criteria:
Inclusion Criteria:

- adulthood with sacroiliac dysfunction

* Their ages will range from 20-40 years old.
* Their BMI will be less than 20- 30kg/m2.
* All of them suffer from mild to moderate degree of sacroiliac pain.
* The subjects complain from sacroiliac pain for 1 month ago

Exclusion Criteria:

* Exclusion criteria were a history of any of the following condition:

  * inflammatory diseases or any rheumatic disorders,
  * a history of vertebral fractures
  * surgical spinal fixation.
  * •any neurological disorders like MS
Safety of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke

This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. The primary objective was to assess the safety and tolerability of NXY-059 compared to placebo.


Eligibility Criteria:
Inclusion Criteria:

* Males and females
* Intracerebral Hemorrhage as the cause of stroke symptoms
* Onset of symptoms within 6 hours
* Full functional independence prior to the present stroke

Exclusion Criteria:

* Unconsciousness
* Subjects who are unlikely to complete the infusion of investigational product and/or are unlikely to undergo active medical management during that period due to a severe clinical condition.
* Severe illness with life expectancy less than 6 months.
* Known severe kidney disorder.
* Current known alcohol or illicit drug abuse or dependence.
* Pregnant or breast-feeding.
* Treatment with acetazolamide and methotrexate is not permitted during the infusion
* Participation in a previous clinical study within 7 days.
* Meets all other exclusion criteria
Validation of a Virtual Model of Service Delivery for Choroidal Nevi

Choroidal nevomelanocytic lesions have a high prevalence affecting up to 7% of the entire population and are increasingly incidentally identified during routine eye check- ups in community optometry services. Given the tendency to err on the side of caution, there is evidence of excessive referrals challenging service delivery in both tertiary eye units and specialist ocular oncology services. Although previous studies have examined the natural history and risk factors for growth of choroidal nevomelanocytic lesions, optimal delivery of management remains uncertain. Management approaches display diversity with respect to the number and type of baseline investigations, the duration and frequency of monitoring of relevant patients. Utilisation of the skills of allied health professionals in appropriate cases would allow streamlining service delivery in a socialised healthcare system, maximise capacity, and allow community services to play an enhanced role. However, the evidence for this model of delivery is lacking. Within existing models of care for these lesions, patients are faced with delays, need for more than one attendances to the hospital and increased anxiety around prognosis.

This project aims to answer the question of whether these low-risk, bland incidental findings might possibly be managed by allied health professionals with the use of clinical imaging and specific algorithms to make appropriate management decisions. We aim to validate a model of service delivery on a virtual basis that will accommodate for capacity pressures to accept all relevant referrals, while offering a safe service and optimising patient experience of care. We will thus validate the setting up of a virtual choroidal nevomelanocytic clinic in terms of safety and patient acceptability. More specifically, the degree of agreement between management decisions made by non-medical graders on the basis of imaging data alone as opposed to gold standard decisions (clinical and imaging tests combined) is examined. Health economics analysis of the proposed service delivery model will be undertaken to demonstrate cost-effectiveness.


Eligibility Criteria:
All patients attending the CNL clinics of MREH/MEH who have offered informed consent will be included in the study. Patients who are then diagnosed with alternate pathologies other than CNL (erroneous referrals) will be excluded from agreement analysis. Recognition of alternate pathologies by non-medical graders will, however, be an additional outcome measure for this project. Cases of Congenital Hypertrophy of the Retinal Pigment Epithelium (CHRPE) will be classified as 'alternate pathology' for the purposes of this study. Exclusion criteria will be media opacities (cornea, lens, vitreous body) precluding adequate visualisation of fundus and incomplete set of imaging data.
Ranolazine Cardioprotection in PCI

The investigators will test if upfront dosing of Ranolazine can reduce myocardial biomarker release (CK-MB, Troponin) post percutaneous coronary intervention (PCI).

Ranolazine has been demonstrated to decrease angina, ischemia on perfusion imaging, improve diastolic function, and cardiac metabolism. Furthermore it has been associated with reduced cardiac arrhythmias, including non-sustained ventricular tachycardia and atrial fibrillation. It has not been studied as an acute cardioprotective agent in percutaneous coronary intervention (PCI).

We hypothesize that upfront administration of Ranolazine could decrease the myocardial injury associated with PCI due to all the factors listed above (i.e. precondition the myocardium). We plan to screen all patients scheduled for an elective coronary angiogram. Those who meet criteria and consent will be randomized to either receive Ranolazine or placebo twice a day for 3 days leading up to the PCI.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 or older
* Patients undergoing Coronary Angiography with possible PCI
* Able and willing to give consent
* Able to read and write English

Exclusion Criteria:

* Current EKG or Biomarker of Acute Myocardial Infarction (MI) or Acute Coronary Syndromes (ACS)
* History of Allergy to Ranolazine
* Pregnant or Nursing
* Currently taking Ranolazine
Epidemiology, Management, Prognosis and Medical Cost Analysis of IHCA and OHCA

The study is a retrospective analysis of Taiwan national health insurance in cardiac arrest patients. The factors related to the outcomes of cardiac arrest patients were analyzed.


Eligibility Criteria:
Inclusion Criteria:

* out-of-hospital cardiac arrest,

Exclusion Criteria:

-
The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2 diabetes, using the arteriovenous difference technique.

Subjects with IGT or type 2 diabetes will be randomised to consume 20ml vinegar (6% acetic acid) or placebo before a mixed meal. Plasma samples will be taken for 300min from the radial artery and from a forearm vein for measurements of glucose, insulin, triglycerides, non-esterified fatty acids (NEFA) and glycerol. Muscle blood flow will be measured with strain-gauge plethysmography. Glucose flux will be calculated as the arteriovenous difference of glucose multiplied by the blood flow rates.

Eligibility Criteria:
Inclusion Criteria:

1. Subjects with impaired glucose tolerance or newly diagnosed type 2 diabetes before the initiation of medication therapy
2. Recreationally active
3. With stable body weight and diet during the last two months.

Exclusion Criteria:

1. Any systemic disease (besides glucose abnormalities)
2. Any medication therapy
3. Diabetic complications
Study on Application of Suturing Parathyroid Markers in Thyroid Cancer Surgery

To study the protective effect of suture parathyroid marker method on the function of parathyroid gland in thyroid cancer surgery

This is a prospective randomized controlled study.In the experimental group, the suture parathyroid marker method was used to mark the parathyroid gland at the first time when it shows, and this marker was further used to identify and locating the inferior parathyroid marker in subsequent central region dissection. In the control group, the central area was routinely cleaned without suture parathyroid marker .

Eligibility Criteria:
Inclusion Criteria:

* Patients with thyroid cancer who need central compartment dissection
* Routine neck incision surgery
* Patients undergoing primary neck surgery

Exclusion Criteria:

* Benign thyroid tumor patients
* Selecting patients with endoscopes, small incisions, or robotic surgery
* Patients with hyperparathyroidism
Endoscopy/Robotic Assisted Nipple Skin Sparing Mastectomy

Non-inferiority study of video-assisted (endoscopic or robotic) skin- and nipple-sparing mastectomy compared to open mastectomy. The feasibility of the technique, oncological safety and cosmetic results will be studied.


Eligibility Criteria:
Inclusion Criteria:

* Women who require a mastectomy and who do not require skin reduction or resection are included. Women with both breast cancer and those at high risk for breast cancer are included.

Exclusion Criteria:

* Sarcomas of the breast.
* Benign breast tumors.
* Prepectoral reconstruction with expansion.
* Impossibility to preserve the skin.
* Need for reduction pattern
* Inability to perform an MRI during follow-up (obesity, claustrophobia, etc.).
* Inability to complete the BREAST-Q™ questionnaire due to the patient's cognitive alterations.
* Refusal of the patient to participate in the study.
Pharmacokinetics and Safety/Tolerability Profiles of DA-5206 Versus Talion® Under Fasting and Fed States in Healthy Male Subjects

This is Open-label, Randomized, 3-sequence study to compare of pharmacokinetics and safety/tolerability profiles betweens DA-5206, a SR formulation of bepotastine besilate and Talion®, a IR formulation of bepotastine besilate under fasting and fed states in healthy male subjects


Eligibility Criteria:
Inclusion Criteria:

* Healthy male volunteer 19 years to 45 years
* Body mass index in the range of 18 to 29 kg/m2 and body weight greater than 50 kg
* The subjects personally signed and dated informed consent document after informed of all pertinent aspects of the study, fully understanding and determided spontaneously to participate

Exclusion Criteria:

* Subject with serious active cardiovascular, respiratory, hepatologic, renal, hematologic, endocrine, urologic, immunologic, dermal, neurologic, or psychological disease or history of such disease
* Subject with acute disease within 28 days before the first dose of Investigational product
* Subject with known for history of disease which affect on the absorption, distribution, metabolism, excretion of drug
* Subjects who are unwilling or unable to use highly effective methods of contraception as outlined in this protocol for the duration of the study
Trefoil Peptides in Lung Diseases

The study focuses on trefoil family factor (TFF) peptides in sputum in lung diseases. The investigators hypothesize that TFF peptides are upregulated in lung diseases characterized by mucus hypersecretion.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 years or older
* Informed consent

Exclusion Criteria:

* Upper and lower airway infection 2 weeks prior to visit 1
Effect of Addition of Dexmedetomidine During Ultrasound Guided Bilateral Single Shot Erector Spinae Plane Block in Patients Undergoing Posterior Lumbar Interbody Fusion Under General Anesthesia

Posterior lumbar interbody fusion (PLIF) is the management of choice in double level lumbar (L) spondylolisthesis (L3-L5) after ineffective conservative treatment. We evaluated bilateral ultrasound (US)-guided single shot erector spinae plane (ESP) block at the level of lumbar 3 (L3) vertebra with or without dexmedetomidine (Dex).

Objectives: Posterior lumbar interbody fusion (PLIF) is the management of choice in double level lumbar (L) spondylolisthesis (L3-L5) after ineffective conservative treatment. We evaluated bilateral ultrasound (US)-guided single shot erector spinae plane (ESP) block at the level of lumbar 3 (L3) vertebra with or without dexmedetomidine (Dex).

Methods: A prospective controlled randomized, double-blind study comparing two groups of patients; each group included 20 patients of double level spondylolisthesis (L3-L5) scheduled for (PLIF) under general anesthesia combined with bilateral US-guided ESP single shot block at (L3). Group I received 20 ml of 0. 25% bupivacaine plus one mL normal saline bilaterally. Group II received 20 ml of 0.25% bupivacaine with supplementation of 1 mL containing 100µg dexmedetomidine bilaterally. Post-Anesthesia Care Unit (PACU) length of stay, the total dose of postoperative analgesics need, postoperative visual analogue score (VAS) at 1h, 6h, 12h, and 24 h after the operation and postoperative complications which related to block or opioids were recorded.

ESP block at combined with (Dex) is a safe, effective block with no complications. Addition of 100µg Dex to preoperative ESP block provided good postoperative opioid-sparing analgesia, facilitated the early emergence and shortened the length of stay in the PACU during (PLIF) for double level spondylolisthesis (L3-L5).

Eligibility Criteria:
Inclusion Criteria:

* belonged to the American Society of Anesthesiologists (ASA) physical status I or II
* either sex
* aged 18-60 years
* body mass index less 35 kg/m2
* complaining from double level lumbar spondylolisthesis (L3-L5)
* scheduled for elective surgical intervention aimed at lumbar spine fixation by PLIF - under general anesthesia.

Exclusion Criteria:

* obesity (body mass index \> 35 kg/m2)
* infection of the skin at the site of the needle puncture
* allergies to either of the study drugs
* bleeding disorder
* and recent use of opioid.
Effects of Aloe Vera Toothpaste on Periodontal Parameters

This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis.

The single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days . This order was reversed in group 2.

Toothpastes are used with tooth brushing to better control microbial plaque. Herbal toothpastes have recently gained attention. This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis.

This single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days and then their plaque index (PI) and gingival index (GI) were recorded. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days and underwent PI and GI assessment again. This order was reversed in group 2. Wilcoxon-Sign Rank and two way Repeated Measure ANOVA tests were applied for statistical analysis.

Eligibility Criteria:
Inclusion Criteria:

* Subjects were selected among dental students with at least 20 natural teeth without systemic disease
* No periodontal treatment at least 6 months to the study
* No use of systemic antibiotic and anti-inflammatory drugs within the last 3 months, nonsmokers, no pregnancy or lactating women
* Subjects with PD≤3mm, (clinical attachment level)CAL\<1mm, PI≥2 and gingival bleeding in more than 30% of the tested areas were enrolled with the diagnosis of plaque-related gingivitis.

Exclusion Criteria:

* Subjects with orthodontic appliances ,multiple bridges, partial denture, multiple caries were excluded from the study
Inmediate Feeding Tolerance in Acute Pancreatitis

Objective: Determine tolerance of immediate oral intake (8 hours posterior to the beginning of treatment) against traditional management (early feeding at 48hr) in patients with mild acute pancreatitis of biliary origin.

Double blind, randomized clinical trial

The investigators included patients 15 - 85 years old, any sex. Diagnosis of mild acute pancreatitis according to the Ranson, APACHE II and BISAP.

Signed infromed consent to participate in the study. All participants had a hepatic and biliary ultrasound to determine the biliary etiology.

The investigators excluded patients with pancreatitis of nonbiliary etiology, pregnant, severe pancreatitis, cholangitis or choledocholithiasis demonstrated during the hospital stay or with other comorbidities.

Eligibility Criteria:
Inclusion Criteria:

Patients older than 15 years.

* Patients with a diagnosis of mild acute pancreatitis biliary.
* Patients who agree to enter the protocol.

Exclusion Criteria:

* Patients managed at another institution.

  * Patients with a diagnosis of pancreatitis of non-biliary etiology.
  * Patients with heart disease or lung disease.
  * Patients with organic failure.
  * Patients with pregnancy.
  * Patients with cholangitis.
Investigating the Physiological Effects of Weight Loss on Male Fertility

The purpose of this study is to determine the physiological effects of weight loss on seminal parameters in male participants with reduced reproductive capacity. Learning more about the physiological role of weight loss on reproductive function and metabolic profile of overweight and obese men may give us a better understanding of male fertility and improve the management of patients with reduced fertility. The effects of weight loss on seminal quality are not well understood.

Participants will receive dietary supplements or National Health Service (NHS) advice on healthy eating to achieve weight loss.

Eligibility Criteria:
Inclusion Criteria:

* Body mass index (BMI) ≥ 30 kg/m\^2 \[Part: 1, 2\& 3\]
* Evidence of reduced reproductive capacity (e.g. reduced sperm concentration \[applicable for study B\]

Exclusion Criteria:

* History of undescended testes, testicular surgery or mumps infection
* Hormonal therapy such as testosterone or selective oestrogen receptor modulators
* History of systemic cytotoxic therapy or pelvic radiotherapy
* Chronic systemic disease, such as cardiac, renal or liver failure
* At least one of the following:

Alcohol intake \>30 units per week Smoking daily Recreational drug use at a frequency not less than weekly

* Acute illness likely to affect the result of study
* Impaired ability to provide full consent to take part in the study
* An occupation requiring strenuous physical exercise that may require a high energy diet
Efficacy and Mechanisms of Mobile-Delivered Alcohol Attentional Bias Modification

This study evaluates the efficacy as well as psychological and neurobiological mechanisms of mobile-delivered alcohol attentional bias modification among heavy drinking adults.

By testing the efficacy and neurobiological mechanisms of behavior change (MOBC) following attentional bias modification among heavy drinking adults, the proposed study has the potential to unify dual process models and neurobiological models of addiction. The cognitive retraining will be delivered via mobile electronic devices to ensure the cost-effectiveness of these procedures, to allow a large amount of retraining to be delivered in an ecologically valid manner, and to facilitate broad dissemination of such procedures if found to be efficacious. Using an intensive longitudinal experimental design, subjects will be randomly assigned into one of 2 groups (attentional bias modification vs. attentional bias control). Ecological momentary assessment (EMA) data will be used to assess changes in cognitive and behavioral measures in situ, and functional magnetic resonance imaging (fMRI) scans before and after cognitive retraining will be used to examine neural changes in specific regions of interest (ROI).

Eligibility Criteria:
Inclusion Criteria:

* Alcohol Use Disorders Identification Test greater than or equal to 8
* right-handed

Exclusion Criteria:

* history of treatment for or diagnosis of alcohol use disorder/substance use disorder
* history of brain injury
* for females, currently pregnant
* any MRI safety contraindication
InSpace™ System in Comparison to Best Repair of Massive Rotator Cuff Tear.

This is a post-marketing study to further assess the safety and effectiveness of the InSpace™ device implantation in comparison to surgical repair of full thickness Massive Rotator Cuff Tear .

This is a post-marketing study to further assess the safety and effectiveness of the InSpace™ device implantation in comparison to surgical repair of full thickness Massive Rotator Cuff Tear .

The effectiveness will be assessed by comparing the shoulder outcome scores of each treatment arm ( ASES, Constant and Quick DASH) from pre-operation (baseline) up to 2 years post-operation, with respect to pain reduction, improvement of activity of daily living (ADL) and improvement of range of motion (ROM).

The safety will be asses by comparing the Adverse event rate between the treatment arms.

Eligibility Criteria:
Main Inclusion Criteria:

* Age 40 or older.
* Positive diagnostic imaging of the affected shoulder indicating full thickness Massive RCT involving more than one tendon.
* Persistent pain and functional disability of the affected shoulder for at least 3 months.

Main Exclusion Criteria :

* Known allergy to the balloon material (copolymer of PLA and -θ-caprolactone).
* Evidence of significant osteoarthritis or cartilage damage in the shoulder
* Evidence of gleno-humeral instability
* Previous surgery of the shoulder in the past 2 years, excluding diagnostic arthroscopy
* Evidence of major joint trauma, infection, or necrosis in the shoulder
* Partial-thickness tears of the rotator cuff
Social Cognition Training in Schizophrenia

People with schizophrenia show deficits in social cognition, the ability to process information about other people such as identifying their emotional expressions. Social cognition is associated with everyday life functioning and could therefore be an important treatment target. Several social cognitive training programs have been developed during the last years. Results indicate that social cognitive performance can be ameliorated through commonly used intervention techniques. However, it is less clear whether this improvement generalizes to everyday life. The purpose of this study is to investigate if a social cognitive training program (Training in Affect Recognition) improves performance on social cognitive and neuropsychological tests and leads to improved everyday life functioning in persons with schizophrenia. The study also aims at examining if an improvement is present three months after completion of the training intervention.


Eligibility Criteria:
Inclusion Criteria:

* age 18-55
* diagnosis of schizophrenia or schizoaffective disorder
* IQ \> 69
* sufficient mastery of Norwegian to undergo assessments

Exclusion Criteria:

* history of head trauma
* neurological/medical condition known to interfere with central nervous system
* receiving outpatient care at time of recruitment