cyrilzakka/clinical-trials huggingface dataset:
Periodontal Health and Its Impact on Oral Health-related Quality of Life Among Diabetes Mellitus Patients

Periodontal diseases, encompassing a range of inflammatory conditions affecting the supporting structures of the teeth, have long been recognized as a prevalent comorbidity in individuals with diabetes. The severity of periodontal disease is usually documented by research clinicians using clinical parameters such as bleeding on probing (BOP), probing pocket depth (PPD), and clinical.

Oral health plays a pivotal role in the overall well-being and quality of life of individuals. Any condition affecting oral health can have far-reaching consequences for an individual's daily life.Both periodontitis and diabetes have been reported to have negative impacts on aspects of daily living and health-related quality of life. Evidence suggests that oral health problems can adversely affect an individual's physical functioning, social standing and wellbeing, and that it can be difficult to dissociate oral health from general health with regards to impacts on quality of life. Oral health-related quality of life (OHRQoL) can be assessed using the Oral Health Impact Profile-14 (OHIP-14) questionnaire

Eligibility Criteria:
Inclusion Criteria:

* Individuals diagnosed with Diabetes Mellitus for case group, non diabetic patients for control group, Age range between 18 to 60 years, informed consent, Participants with varying degrees of periodontal health

Exclusion Criteria:

* Participants with severe systemic illnesses and habits that may significantly affect oral health or quality of life, Individuals with severe cognitive impairment or psychiatric conditions that hinder their ability to participate and provide informed consent.
Observational Study on Safety and Efficacy of NovoSeven® in Subjects With Congenital FVII Deficiency

This study is conducted in Japan. The aim of this observational study is to evaluate the long-term safety and efficacy of activated recombinant human factor VII (NovoSeven®) in subjects with congenital FVII deficiency.


Eligibility Criteria:
Inclusion Criteria:

* Congenital FVII deficiency
* Never been treated with NovoSeven® before
* Patients already in treatment with NovoSeven®

Exclusion Criteria:

* History of hypersensitivity to any of the components in NovoSeven®
Study of Health-risk Behaviours (Tobacco, Alcohol or Drug Consumption ; Nutrition ; Sedentary Lifestyle ; Sexual Practices) Among Cancer Survivors

* Cancer is now becoming a chronic condition though it was, until a short time ago, a fatal illness. Thus, according to the French national cancer institute, nearly 4 million French people have been diagnosed with cancer in their lifetime.
* Screening is used to detect the presence of a pathology at an early, infra-clinical stage, or the presence of a risk factor in people who are supposedly healthy.
* There are three organized screening programs in France (breast cancer, colorectal cancer, cervical cancer), as well as many others recommended by learned societies such as the National Authority for Health . However, they are underused, far from European recommendations and government targets.
* According to DREES (research, studies, evaluation and statistic department), public health and primary prevention interventions could have prevented 143 deaths per 100.000 inhabitants, and healthcare interventions could have spared 59 deaths per 100.000 inhabitants, for a total of 202 avoidable deaths per 100.000 inhabitants in France in 2020.
* As for cancers, French national cancer institute estimates the rate of avoidable cancers in France in 2023 at 40%. Breast cancer, for example, is the most common cancer that can be associated with alcohol consumption and estimations suggest that nearly 20.000 breast cancers could be prevented each year (a third of new cancer cases in 2018).
* In France, prevention accounts for 5.5% of healthcare expenses in 2021, with 46% for individual primary prevention, 41% for individual secondary prevention and 12% for collective prevention and prevention programs. These healthcare expenses must be set against the social cost of each risk factor, to see how important they are.
* Relative burden of cancer and noncancer mortality among long-term survivors of breast, prostate, and colorectal cancer in the US has been demonstrated. It shows that "patients with low oncologic risk at the time of diagnosis had at least 3-fold higher risk of noncancer death compared with death from the index cancer".
* In France, medical desertification is a reality. Now, according to the VICAN-5 study, nearly a third of cancer patients are not followed up by general practitioners. Though primary prevention is one of GP's prerogatives and a governmental priority.
* There is a high interest in screening and preventive action to limit the risk of other avoidable pathologies, whether cancerous or not.

The research hypothesis is that a customized screening will enable the implementation of comprehensive preventive action to limit the onset of avoidable diseases (second cancer or other pathology) for cancer survivors.


Eligibility Criteria:
Inclusion Criteria:

* Cancer survivor
* Up to 74 years old
* Less than a year from the end of their heavy treatments
* Participating in JUMP post-cancer day.

Exclusion Criteria:

* Patients with cognitive disorders that limit their ability to understand and complete the questionnaire.
* Patients who do not speak, read and write French.
Pilot: Group Therapy for Children Who Stammer

The aim of the study is to answer the question: Is a large-scale research study of the effectiveness of group speech and language therapy (SALT) for young people who stammer possible?

The study will look at the issues involved in setting up a large-scale investigation of treatment for young people who stammer. It will inform the investigators whether larger studies would be possible and give some early-stage information on the effectiveness of group SALT for these young people. The findings will pave the way for building and testing out treatment programmes where there will be clear positive benefit for young people who stammer and their families.

To answer the research question, the study will tell the investigators (a) how easy/difficult it was to get people to take part, (b) young people and parents'/carers' views on taking part and (c) whether the assessments were able to pick up changes in speech and attitudes towards stammering reported by the young people and their carers.

Sufficient numbers of participants were not recruited to carry out the intended rehearsal pilot RCT study design.


Eligibility Criteria:
Inclusion Criteria:

* Aged between 8;0 years and 15;11 years at 20.07.09
* Currently in treatment, on review or on waiting list for treatment.
* Has had an initial NHS Speech and Language Therapy assessment by Newcastle, Northumberland or North Tyneside Speech and Language Therapy service.
* Has a diagnosis of stammering.
* Has sufficient understanding of spoken (English) language to score at or above the 16th percentile on the Understanding Linguistic Concepts subtest of the CELF-4UK assessment.
* Available to attend treatment for the whole week of 20th July 2009
* Available to attend treatment for the whole week of 24th August 2009

Exclusion Criteria:

* Diagnosis of Attention and/or Hyperactivity Disorders
* Diagnosis of moderate or severe general learning difficulties
* Diagnosis of moderate or severe receptive and/or pragmatic language difficulties
* Parent/carer for whom an interpreter would be required
The Effect of the Massage on Cramp Frequency, Cramp Severity, and Sleep Quality

The aim of this randomized controlled experimental study was to determine the effect of the massage applied to hemodialysis patients with complaint of cramp on the cramp frequency, cramp severity, and sleep quality.

The study was conducted with patients receiving treatment in a total of four hemodialysis units. The sample of the study comprised a total of 36 patients (18 patients in the intervention group and 18 patients in the control group) with complaint of cramp. In the study, intradialytic massage for lower extremity was applied to the intervention group in three sessions a week and a total of six sessions for two weeks. No intervention other than routine care was applied to the control group patients.

In the study, the data were collected using a patient information form, cramp assessment short survey, the "Visual Analog Scale (VAS)", "Pittsburgh Sleep Quality Index" (PUKİ), and patient follow-up forms.

In order to conduct the study, the necessary Ethics Committee approval and institutional permission were obtained. The individuals included in the study informed about the purpose of the research, their verbal consent obtained and the participant's informed consent form signed.

After the intervention and control groups were assigned according to the research criteria, the days and sessions of the groups were determined and recorded in the digital randomization environment.

Eligibility Criteria:
Inclusion Criteria:

* 18 years,
* One or more lower work cramp attacks during/after dialysis
* Have a constant dryness in the last 1 month (few changes weighing more than 2 kg)
* Receiving at least 6 hemodialysis treatments
* Receiving hemodialysis treatment 3 times a week
* Those who have not received sub-massage therapy before

Exclusion Criteria:

* Having one of the diagnoses of chronic obstructive pulmonary disease, cancer, psychiatric disease
* Presence of any soft tissue, nerve and vascular disease in the lower extremities
* Presence of infection, open wound, suspected fracture, dermatitis, burn and edema in the lower extremities
* Having had a lower extremity operation in the past six weeks
* Receiving hemodialysis treatment for less than 6 months (new patients are excluded because the first few months of dialysis treatment are periods of hemodynamic instability)
* Having a fluctuating dry weight (excluded from the study as it may cause cramping)
* Having been diagnosed with neuropathy in the lower extremities
Serratus Anterior Block and Erector Spinae Block in Postoperative Analgesia

90 patients scheduled for thoracic cancer surgeries, allocated in 3 groups for serratus anterior block and erector spinae block and control group. during anaesthesia:total intraoperative fentanyl required will be recorded. After surgery, all patients will be connected to PCA device containing morphine solution, the amount of morphine consumed during the first 24 hours will be recorded.

90 patients scheduled for thoracic cancer surgeries, allocated in 3 groups for serratus anterior block (SAB) and erector spinae block (ESB) and control group. During anaesthesia: total intraoperative fentanyl required will be recorded. After surgery, all patients will be connected to PCA device containing morphine solution, the amount of morphine consumed during the first 24 hours will be recorded. Other secondary outcomes are: numerical rating scales and postoperative pulmonary functions.

Eligibility Criteria:
Inclusion Criteria:

* Patients with class II physical status (American Society of Anaesthesiologists) ,
* Age between 18-70 years,
* Scheduled for thoracic cancer surgery

Exclusion Criteria:

* Patient refusal.
* Local infection at the site of the block.
* Cardiac dysfunction (ejection fraction \<45%).
* Significant respiratory disorders.
* Preexisting neurological or psychiatric disease.
* Allergy to one of the study drugs.
* Pregnancy.
* Coagulopathy
Laryngeal Disorders After Childhood Cardiac Surgery

Laryngeal disorders after childhood cardiac surgery is a complication well described in the literature. However, the long term progression of the affected children has never been studied (all the studies stopped before 2 years of follow up).


Eligibility Criteria:
Inclusion Criteria:

* No opposition from children and parents
* Patient or parents able to understand the ins and outs of the study

Exclusion Criteria:

* None
Smoking Cessation for Smokers With Sleep Problems

This is a pilot research study examining two types of behavioral counseling along with the nicotine patch for smoking cessation. The study is designed to find out whether one of these counseling interventions is more effective for smoking cessation among individuals with sleep problems. The study has three parts: 1) an intake session; 2) a 10-week treatment phase, and 3) a 1-month follow-up.

This is a developmental study to: 1) create and test an integrated cognitive-behavioral smoking cessation and insomnia intervention with 30 smokers who report current insomnia. Participants are randomized to 1 of 2 counseling conditions. The cognitive-behavioral intervention provides standard care smoking counseling along with counseling to address insomnia. The smoking counseling intervention provides standard care smoking counseling adapted from the American Lung Association Freedom from Smoking program. Efficacy data from this trial will be used to determine effect size estimates for biologically confirmed self-reported point prevalence smoking abstinence at the end of treatment and 1 month after completing treatment. Changes in sleep efficiency and self-control to resist smoking urges will also be examined. If the effect size estimates are sufficiently large and medically important to pursue a definitive trial, these data will be used to propose a full scale large study.

Eligibility Criteria:
Inclusion Criteria:

* Between the ages of 18 and 75.
* Smoking 10 or more cigarettes per day for at least 1 year.
* An expired air breath carbon monoxide level \> 10 ppm.
* Motivated to stop smoking.
* Understand English.
* Meet DSM-IV criteria for insomnia.
* Report sleep latency or waking after sleep onset \>30 minutes on ≥6 occasions within past month.

Exclusion Criteria:

* History of allergic reactions to adhesives.
* Unstable psychiatric/medical conditions such as current suicidal or homicidal ideation, acute psychosis, dementia.
* Have a current diagnosis of DSM-IV alcohol or drug dependence other than nicotine.
* Use of tobacco products other than cigarettes or use of marijuana.
* Intention to use nicotine replacement therapy, varenicline, or bupropion during study participation.
* Females of childbearing potential who are pregnant, nursing, or not practicing effective contraception (oral, injectable, or implantable contraceptives, intrauterine device, or barrier method with spermicide).
* New onset of psychiatric disorders or new psychotropic medications within the past 3 months.
* Inability to read/understand English.
* History of sleep apnea based on responses to Berlin Questionnaire.
* History of restless leg syndrome.
* Current night or rotating shift work.
* Proposed travel across 2 or more time zones during study participation.
* Medical/psychiatric conditions contraindicated for sleep restriction (i.e., seizure disorders, severe excessive daytime sleepiness - Epworth Scale \>18, and bipolar disorder).
Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol

Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.


Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists physical status (ASA PS) I-II
* Age 20 - 60 years male and female
* Elective schedule with minor surgery under general anesthesia

Exclusion Criteria:

* Body mass index (BMI) \>= 30 (kg/m2)
* Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history
* Patient with medication affecting on this study
* Patient with general anesthesia history within one month
Vitamin D Supplementation and Immunity/Physical Performance

The purpose of this study is to examine the effect of vitamin D supplementation on vitamin D status, immunity and physical performance.

Vitamin D plays a key role in bone mineralisation and has been linked to immune defence maintenance and muscle function. Vitamin D is primarily obtained from endogenous synthesis in response to skin sunlight exposure and follows a seasonal pattern; whereby, vitamin D levels peak at the end of the summer and fall to a trough during winter. If winter vitamin D levels can be increased to match those found in summer using supplementation, it is proposed sufficient vitamin D levels will improve physical performance and reduce susceptibility to illness in military recruits.

Eligibility Criteria:
Inclusion Criteria:

* Passed medical assessment by medical doctor

Exclusion Criteria:

* Medically deferred by medical doctor
* Regular sun bed use
* Holiday in a hot sunny climate in \<3 months
* Regular vitamin D supplementation
The Impact of Preoperative Supplementation of Zinc

1. Pre operative anthropometric assessment including : weight in kg, height/length and BMI
2. Pre operative Zinc supplementation (dose according to the age) for 7 days preoperatively for cases
3. Postoperative data collection

Postoperative data collection :

* Length of hospital stay
* Complication and sorting of them
* Lab withdrawal of inflammatory markers on 2-3 day postoperatively

Eligibility Criteria:
Inclusion Criteria:

1. All children patients with Hirschsprung disease admitted for surgical intervention with different ( age , sex )
2. Type of surgery : transanal pull through
3. Whose parents or caregivers approve for the participation in the study

Exclusion Criteria:

1. Patients with emergency situations
2. Whose parents or caregivers will not apply for the participation in the study
Outpatient Care for Multiparas After Elective Cesarean Section: an Observational Study

The purpose of the study is to evaluate whether outpatient cesarean section can be performed in multiparous women without significant decrease in the parents' sense of security .


Eligibility Criteria:
Inclusion Criteria:

* Planned elective cesarean section of multiparous women
* Singleton pregnancy
* Age of at least 18
* Gestational age between 37 and 42 weeks
* Internet access at home

Exclusion Criteria:

* Lack of consent
* Women with no or little understanding of Danish and ability to speak Danish.
* Allergies to medicine included in the pain management regimes
* Expected maternal or neonatal complications after delivery
* Birth weight of less than 2500 grams
Effects of ACEI on Bone Turnover

The investigators hypothesize that older persons (≥45 years) treated with ACEI for HTN control will have: i) improved status of bone turnover (decreased P1NP and CTX), and ii) decreased levels of RANKL and RANKL/OPG, compared to those not treated with ACEI and not using RAS-related medications


Eligibility Criteria:
Inclusion Criteria:

* at least 45 years of age
* a diagnosis of (either new or uncontrolled) HTN who will need a new medication for HTN control
* able to consent (no medial issues impairing judgment for consenting based on clinical providers' judgment).

Exclusion Criteria:

* younger than 45 years of age
* a diagnosis of metabolic bone disease
* a diagnosis of osteoporosis or use of medication to treat osteoporosis
* a diagnosis of diabetes mellitus, or renal insufficiency, or cancer
* history of allergy to ACEI or ARB, 6) history of use of ACEI or ARB.
Hairy Cell Leukemia Patient Data Registry

The overall objective is to develop a clinical data registry that can be used to facilitate research with the ultimate goal of reducing the morbidity and/or mortality and improving the quality of life of patients diagnosed or living with hairy cell leukemia. With approximately 1,000 new cases of this rare disease identified in the US each year, HCL represents 2% of all cases of leukemia in adults. Considering the rarity of this chronic leukemia, the Hairy Cell Leukemia Foundation (HCLF), in partnership with investigators from its Centers of Excellence, seeks to develop a registry to help researchers identify new trends in outcomes, recognize the most effective treatments, discover previously unknown complications of the disease, and design clinical trials for new therapies.

This clinical registry is being established to collect de-identified information on this rare disease. The registry created by assimilation of de- identified coded patient data will centralize information that can be used to improve the management of the many complications of this disease and its treatment. This study is focused on collection of clinically and biologically meaningful endpoints across multiple institutions; as such, it is not focused on a specific set of hypotheses but will collect data that will facilitate such analyses. The investigators will collect information related to the symptoms and the clinical course of the disease, to the complications from the disease and its treatment, presence of minimal residual disease, frequency of relapse and subsequent management, data on novel molecular markers associated with the prognosis.

In conjunction with the Department of Bioinformatics at The Ohio State University, the investigators have created a system for safeguarding the confidentiality and the identity of all patients who agree to participate in this research registry. Each participating institution will be responsible for de-identification of the data, using software developed by The Ohio State University, Department of Biomedical Informatics, before it is used in the registry. Each institution will confidentially maintain a code for linking this information to an individual patient.

Each participating institution will have direct control over the data contained in the registry that is associated with their respective patient population. As a result of these measures, should a patient wish to withdraw from the registry, the responsible institution will be able to immediately remove all records related to that patient from the registry.

Eligibility Criteria:
Inclusion:

* Patients with classic hairy cell leukemia
* Patients with the variant of hairy cell leukemia.

Exclusion:

* Children are excluded from the study, since Hairy Cell Leukemia wasn't described in children.
Influencing Factors on Gait Variability in PD

The principal motor features of Parkinson's disease (PD) include rigidity, tremor, bradykinesia, and postural instability. These motor deficits might cause gait dysfunction including reduced gait velocity, stride length, arm swing, and increased gait variability. Among these, increase in gait variability increased fall risk and served as a marker of disease progression. Previous studies reported that some factors might influence gait variability. However, which one contributes most has not yet been verified. Therefore, the purpose of the present study is to identify the more related influencing factors on gait variability in people with PD.


Eligibility Criteria:
Inclusion Criteria:

* Idiopathic PD
* Hoehn and Yahr stages I through III
* Ability to stand and walk 5 m independently with or without any walking aids
* Stable medication usage

Exclusion Criteria:

* Unstable medical conditions
* Any neurological, cardiopulmonary or orthopedic problem/diseases that may interfere with participating the study