cyrilzakka/clinical-trials huggingface dataset:
Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia

The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways.

The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects.

The coherence between structural and functional anomalies will be especially studied.


Eligibility Criteria:
Inclusion criteria (controls):

* Aged from 18-65 Y
* Right handed

Additional inclusion criteria for patients:

* Schizophrenia according to the DSM5
* Either periodic catatonia or cataphasia according to the WKL classification
* Under stable medication regimen (\> 1M)

Exclusion criteria:

* Current substance abuse
* Contraindication to MRI
* Past records susceptible to affect brain integrity
* Severe, unstable medical condition
* Pregnancy
* Patients deprived of their rights
Multifactorial Intervention on Frailty in Vulnerable Older Adults

Frailty is a highly prevalent, progressive condition in older adults that is characterized by multisystem physiologic impairments and vulnerability to stressful events, leading to increased risk of geriatric conditions, disability, falls, hospitalization, and mortality. An effective public health intervention to improve frailty in a rural aging population with limited resources remains unknown. The purpose of our study is to evaluate the effectiveness of multidimensional public health intervention to reduce frailty and related geriatric conditions in older adults in rural communities. Our hypotheses are that a multidimensional intervention consisting of group exercise, nutritional support, depression management, polypharmacy, and home safety intervention over a 6-month period will improve frailty and selected geriatric conditions in older adults who are in low socioeconomic status or living alone in a rural community. Our primary outcome is short physical performance battery at 6 month. Secondary outcomes include frailty status, nutritional status, depression, falls, sarcopenia, and health care utilization. The investigators will conduct a designed delay trial by implementing our intervention in one town for the first 6 months (intervention group), while measuring the outcomes without any intervention in another town (serving as a control group); in the following 6 months, the investigators will implement the 6-month intervention in the control town. The findings from our study will inform us to find effective public health interventions to promote healthy aging in resource-limited, rural populations.


Eligibility Criteria:
Inclusion Criteria:

1. Currently living in the PyeongChang county, GangWon province, South Korea
2. Aged 65 years or older
3. Living alone or receiving Medical aid services
4. Sign informed consent

Exclusion Criteria:

1. Unable to walk 100 meters, with or without assistive devices
2. Institutionalized for the past 6 months
3. Known metastatic cancer, end-stage heart disease, end-stage renal disease
4. Moderate to severe cognitive impairment (MMSE ≤ 18)
5. Plan to move out of the current residence in the next 6 months
TeleRehab to Restore Upper Limb Function in People With Chronic TBI

The study aims to inform the subsequent large-scale clinical trial focused on using telerehabilitation techniques and technologies to improve upper limb function and quality of life.

Upper limb (UL) function is often impaired and not fully recovered after moderate-to-severe traumatic brain injury (TBI), leading to devastating consequences and reducing quality of life. Clinicians have been encouraged to include UL rehabilitation, but existing evidence is insufficient to inform specific treatments for the TBI population. There is urgency to broaden the scientific evidence critical to advancing UL rehabilitation for TBI survivors, especially those living in the community with chronic UL impairment.

The study will examine two UL exercise programs through tele-rehabilitation (TeleRehab) techniques. Both programs are focused on functional tasks and daily activities. One program is implemented directly in the real-life home environment, the home-based arm and hand exercise (HAHE) program. The other program is delivered through simulated real-world scenarios, the exercise video game (Exergame) program. The HAHE program consists of UL exercises based on real-life activities that involve materials and objects readily available at home or easily obtained in regular stores. The Exergame program packages UL exercises into game-like activities delivered through a non-immersive virtual reality device.

Individuals with chronic UL impairment after moderate-to-severe TBI will participate in the proposed study. They will be randomly assigned to the HAHE or the Exergame program. Patients will complete 30 sessions of the assigned program over 6 weeks at home, with no immediate supervision. An occupational therapist will review the progress, assist in goal setting, and provide consultation to patients at the beginning of each week via a video call. The investigators will determine which of the programs is effective, and whether the programs lead to similar or different outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Time post injury \> 12 months
* Moderate-to-severe TBI
* One upper limb (UL) is more affected than the other, and the participant reports impaired UL function because of the more affected limb.
* The more affected limb is at the Brunnstrom Stage 3, 4, or 5 of Arm Recovery .
* Meeting the following technology requirements: possessing and using a smartphone, Internet connection at home, and having a TV at home

Exclusion Criteria:

* \< 18 years old at the time of injury
* A history of previous neurological disorder
* A history of substance abuse requiring inpatient treatment
* The more affected limb is at the Brunnstrom Stage 1, 2, 6, or 7 of Arm Recovery.
* Experiencing severe pain during the Brunnstrom Stage evaluation
* Active subluxation of the shoulders
* Living outside of the 50-mile radius of Kessler Foundation (West Orange, NJ)
Interest of Intravenous Cholangiography With Indocyanine Green in the Context of Laparoscopic Cholecystectomy for Grade 1 and 2 Acute Gallstone Cholecystitis

Acute lithiasis cholecystitis (ALC) is the third most common cause of surgical emergency admission. The initial treatment of ALC associates a medical support and a cholecystectomy, preferentially performed laparoscopically in the first 5 days of evolution. During the surgery, intraoperative cholangiography (CPO) using a contrast product is the "gold standard" to identify the bile ducts. However CPO is performed in approximately 30% of laparoscopic cholecystectomy.

Laparoscopic cholecystectomy for ALC is associated with an increase in the rate of biliary ducts injuries compared with cholecystectomy for symptomatic vesicular lithiasis, evaluated at 0.8 % versus 0.1 %. Its higher rate is related to local inflammation that alters the biliary anatomy and complicates the identification of the bile ducts. Indocyanine green facilitates the visualization of extrahepatic biliary structures, which could reduce the risk of biliary wound and shorten the operating time.


Eligibility Criteria:
Inclusion Criteria:

* Adults patient (\>18 years old)
* Patients requiring laparoscopic cholecystectomy for grade 1 or 2 acute gallstone cholecystitis according to Tokyo recommendations confirmed by radiological morphological examination
* Acute lithiasis cholecystitis (ALC) evolving for less than 5 days
* Patients affiliated to a social security scheme

Exclusion Criteria:

* Antecedent of biliary tract surgery
* Antecedent of cholecystectomy
* Contraindication to laparoscopy
* Contraindication to surgery
* Cholecystectomy by laparotomy out of hand
* Grade 3 cholecystitis according to Tokyo recommendations
* Acute alithiasis cholecystitis
* Cirrhosis
* Conversion for gangrenous ALC
* Patient with an allergy to indocyanine green
* Pregnant or lactating woman, childbearing age without effective contraception
* Minor patient
* Physical or psychological state that does not allow participation in the study, patient under guardianship or curatorship or patient deprived of liberty by a judicial or administrative decision (according with articles L 1121-6 and L 1121-8 of the French Public Health Code)
The Optimal Timing Of Primaquine To Prevent Malaria Transmission After Artemisinin-Combination Therapy

The investigators' Hypothesis is that "The correct timing of gametocytocidal drug in combination with an effective Artemisinin Combination Therapy can limit the infectiousness of malaria-infected individuals to less than one week after initiation of treatment"

Global malaria elimination is back on the agenda, gametocytocidal drugs such as primaquine are currently advocated for use in the interventions that aim to interrupt malaria transmission and hence elimination. Mature gametocytes are responsible for malaria transmission. Artemisinin based combination therapies (ACTs) has limited effect on the young gametocytes. Primaquine is able to clear mature gametocytes that remain after treatment with ACTs. Complete clearance of mature gametocytes will depend on the ideal time primaquine is given after ACT. It is important therefore that is administered at optimal time in order to have significant impact on clearing gametocytes to interrupt malaria transmission. An additional consideration is operational administration of Primaquine and compliance both of which are likely to be enhanced if the drug is administered on the day of diagnosis.

In this study, the investigators aim to determine optimal timing of primaquine administration in addition to ACT by comparing administration on day 0 with administration on day 2.

The investigators' primary end points are gametocyte prevalence and density by microscopy and Quantitative Nucleic Acid Based Amplification (QT-NASBA) on day 14, which will be compared between the two primaquine treatment arms.

Eligibility Criteria:
Inclusion Criteria:

* Age 3 years - 17 years
* Residents of research area
* Willingness to come for complete scheduled follow-up.
* Uncomplicated malaria with P. falciparum mono-infection
* Axillary temperature \> 37.5°C and \< 39.5°C, or history of fever in previous 48 hours.
* No history of adverse reactions to study medication
* Understanding of the procedures of the study by parent or guardian and willing to participate by signing written informed consent forms

Exclusion Criteria:

* Haemoglobin below 9g/dl
* Inability to take drugs orally
* Known hypersensitivity to any of the drugs given
* Reported treatment with antimalarial chemotherapy in the past 2 weeks
* Evidence of chronic disease or acute infection other than malaria
* Domicile outside the study area
* Signs of severe malaria( such as respiratory distress, altered consciousness deep breathing, anaemia)
* Participating in other malaria studies conducted in the region
* Mixed malaria parasite species infection
* Positive pregnant test by Urine (UPT) if participant is female aged above 12 years
* G6PD deficient using the fluorescence spot test
Impaired Decision Making in Pedophilic Offenders

Pedophilic behaviors represent a public health problem with serious consequences. The investigators hypothesize a disruption in the decision-making strategies among sex offenders pedophiles. Highlight this type of abnormality would offer a specific treatment of a possible neuropsychological deficit (with cognitive remediation for instance) and perhaps avoid recurrences of this type of behavior.

Cross-sectional study, comparing a group of 64 pedophilic offenders inmates condamned with a group of 64 volunteers non-pedophiles matched by age and level of study.

Eligibility Criteria:
Inclusion Criteria:

* For the controls, lack of diagnosis of disorders of sexual behavior (paraphilias) current or past (DSM IV)
* For the pedophilic offenders:

  * Placement and conviction for rape or sexual assault of a minor under 15 years
  * Recognition of the facts
  * Existence of a current or past diagnosis of pedophilia (according to the DSM IV).

Exclusion Criteria:

* Presence of a current major depressive episode (DSM IV - MINI)
* History of cerebral neurological disorder or a cranial trauma with loss of consciousness current
* IGT test already done
* Schizophrenia or Other current psychotic disorders(according to the criteria DSM IV of MINI test).
* taking psychoactive drug
Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy

The purpose of this pilot study is to employ multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin lesions for characterization of their morphologic and functional features. .

This study is performed using a multiphoton microscopy-based tomograph (MPTflex) developed by JenLab, GmbH (Germany) to image non-invasively normal and lesional skin. Skin lesions are imaged by multiphoton microscopy and images are compared to those obtained from histopathology through standard of care processed skin biopsies.

Any biopsies will be performed by the health care provider as a standard of care procedure.

Eligibility Criteria:
Inclusion Criteria:

* Male or Female all age groups
* Ability to understand and carry out subject instructions

Exclusion Criteria:

* Pregnant women
Functional Importance of a Powered Multifunction Wrist Protocol

The focus of this study is to conduct a clinical study in individuals with transradial amputations to compare function using a 1-DOF or 2-DOF wrist. All prostheses will be attached to a single DOF Otto Bock hand and controlled using a pattern recognition system equivalent to the Coapt system. This study will enable the investigator to quantify the relative functional value of powered wrist flexion during both in-laboratory testing and home use. In addition, the investigators will address the effectiveness of different hand-wrist combinations to enhance patient-centered clinical decision making.

The primary objective of this project is to evaluate the functional importance of a multi function wrist compared to a single degree of freedom wrist. This will be accomplished through in laboratory testing and an 8-week home trial. The first aim will involve in-laboratory functional performance testing with a 1-DOF or a 2-DOF wrist and a one degree of freedom hand.

Changes in performance will be assessed with multiple outcome measures that include both quantitative and qualitative testing of prosthesis control and functional performance. The second aim will determine how a 2-DOF wrist impacts control and home use of a one degree of freedom hand. Subjects will compete an 8 week home based trial. Participants will be instructed to complete a written home log of activities and electronic logging usage data will also be collected for each experimental condition. The investigators hypothesize that adding a wrist flexion/extension module to a wrist rotation module and a single-DOF terminal device will provide significant improvements in function for transradial amputees.

Eligibility Criteria:
Inclusion Criteria:

* Ages 18-95
* A unilateral upper limb amputation or absence below the elbow
* English speaking

Exclusion Criteria:

* Significant new injury that would prevent use of a prosthesis: The ability to consistently wear a prosthesis and perform activities of daily living and specific performance tasks is necessary to evaluate the relative benefits of the interventions.
* Cognitive impairment sufficient to adversely affect understanding of or compliance with study requirements, ability to communicate experiences, or ability to give informed consent: The ability to understand and comply with requirements of the study is essential in order for the study to generate useable, reliable data. The ability to obtain relevant user feedback through questionnaires and informal discussion adds significant value to this study.
* Significant other comorbidity: Any other medical issues or injuries that would preclude completion of the study, use of the prostheses, or that would otherwise prevent acquisition of useable data by researchers
Salivary Calcium in Post-menopausal Women and Prevalence of Dental Caries

Different phases of a woman's life are puberty, menses, pregnancy, and menopause. Menopause is one of the normal developmental stages in a woman's life, marks the permanent cessation of menstruation. It occurs due to irreversible changes in the hormones.The gradual variation and circulating sex hormones affect women's psychological balance and quality of life. The hormonal changes affect the reproductory system and affect the bone integrity and overall health of the individual. The only source of oocytes in women is an ovary. That is the primary source of oestrogens and progesterone, majorly the androgens. Therefore, various systemic health concerns like vasomotor symptoms, cardiovascular diseases, cancer, sexual problems, osteoporosis, and poor oral health

The presence of estrogen receptors detected through immunohistochemistry in the oral cavity plays a significant role in associating the effect of post-menopausal conditions to variations in the oral environment like salivary hypofunction, oral discomfort, and oral mucosal disorders. The vaginal mucosa and oral mucosa are similar histologically due to stratified squamous epithelium and desquamative growth pattern. Therefore, the variation in hormonal status in post-menopausal women may lead to the proliferation and maturation of oral epithelium in response to circulating estrogens. The keratinocytes and fibroblasts in the gingival tissues are majorly targeted by estrogen leading to periodontitis, fibroblastic hyperplasia, and desquamatic lesions. Therefore, it is a proven fact that gingiva is a traditional estrogen target, leading to the destruction of supporting structures of a tooth, causing periodontitis and thereby exposing tooth structure. Another primary oral manifestation in menopausal women is xerostomia/dryness of the mouth. The salivary components provide defense by maintaining the desired pH and decreasing the prevalence of caries, but estrogen levels directly decrease the salivary flow rate. Thus, the prevalent acidic pH causes demineralization and destruction of enamel, dentin making it more susceptible to dental caries.

A correlation between bone mineral density, salivary calcium levels, and estrogen levels is already established. Hence, the salivary calcium levels can indicate increased demineralization of tooth surface and osteoporosis in menopausal. Hence, the present focuses on estimating salivary calcium levels and their association with the prevalence of dental caries in post-menopausal women.

Eligibility Criteria:
Inclusion Criteria:

* No metabolic disorders
* No medications taken in the past 3 months
* No periodontal disease

Exclusion Criteria:

* Periodontal disease present
* Metabolic disease present
* Medications taken in the past 3 months
Seoul National University Prospectively Enrolled Registry for Prostate Cancer With Active Surveillance

In this study, the investigators aim to establish the prostate cancer active surveillance prospective cohort in our institution, and finally investigate the 5 year rates of reclassification during active surveillance as the primary endpoint of the current study.

Prostate cancer (PCa) remains one of the most commonly diagnosed malignancies in men worldwide. Early diagnosis and definitive therapy seem to improve oncological outcomes in men with high-risk disease, but significant concerns exist in terms of the overdiagnosis and overtreatment of patients with lower-risk tumors. In this context, active surveillance (AS) has recently emerged as a alternative treatment strategy in PCa patients with low risk cancers. However, published data are based on Western population with different protocol, and therefore; well-controlled data with well-organized and prospective cohort are urgently needed in Korean patients with low-risk PCa because Korean patients have significantly different tumor characteristics compared to Western patients. Here, the investigators have a plan to establish the Seoul National University Enrolled Registry for Prostate Cancer with Active Surveillance, and finally provide the concrete evidence for the clinical outcomes of active surveillance program as the primary therapeutic strategy for low-risk PCa in Korean men.

Eligibility Criteria:
Inclusion Criteria:

1. Men \< 80 years
2. Pathologically proven adenocarcinoma of the prostate by transrectal prostate biopsy ≥ 10 cores
3. Pre-Bx PSA ≤ 10ng/ml
4. PSA density \< 0.15ng/ml/ml
5. Clinical stage T1-2a
6. Biopsy Gleason score ≤ 6
7. No. of positive cores ≤ 2
8. Maximum cancer involvement in any one core ≤ 20%.
9. No PIRADS 5 lesion on multiparametric prostate MRI (1.5T or 3T)
10. Participants must be willing to attend the follow-up visits - T1a-b disease should be confirmed by systematic TRUS-Bx ≥ 10 cores

Exclusion Criteria:

1. A former therapy for prostate cancer.
The Efficiency of Writing Endoscopic Reports by Artificial Intelligence and Physicians: a Randomized Controlled Trial

The purpose of this study is to compare the efficiency of writing endoscopic reports by artificial intelligence and physicians through a randomized controlled trial.

Digestive endoscopy permits early detection of gastrointestinal diseases and improving the patients' quality of life. However, writing endoscopic report takes a lot of manpower and time, reducing the efficiency of endoscopy. Our center has developed a structured diagnostic report generation system for digestive endoscopy, which can generates the report by artificial intelligence. Here, we compare the efficiency of writing endoscopic reports by artificial intelligence and physicians through a randomized controlled trial.

Eligibility Criteria:
Inclusion Criteria:

* patients aged between 18 and 80 years；
* patients undergoing gastroscopy and colonoscopy examination with anesthesia；
* patients able to give informed consent

Exclusion Criteria:

* patients with the contraindications to endoscopic examination;
* a history of gastrointestinal cancers;
* allergic to anaesthetics in previous medical history;
* the endoscopic procedure cannot be completed due to stenosis, obstruction, solid food or complications of anaesthesia.
A Registry of De Winter Symdrome of Single Center

This registry started January 1,2018 to collect patients who diagnosed as De Winter Symdrome for the first time in Hainan General Hospital.All enrolled patients will receive 30 days followed-up.


Eligibility Criteria:
Inclusion Criteria:

* Index ECG ST segment showed a 1- to 3-mm upsloping ST-segment depression at the J point in leads V1 to V6 that continued into tall, positive symmetrical T waves
* Received coronary angiography during hospitalization

Exclusion Criteria:

-No coronary angiography results was available during hospitalization
Use of Theater to Invoke Empathy and Reduce Bias in Medical Students

The effect of medical humanities on medical student bias and clinical management is unclear. This study characterized medical student attitudes toward obese individuals and whether reading a play employing empathic characters can modulate negative reactions.


Eligibility Criteria:
Inclusion Criteria:

* medical student at UC Davis, UC Irvine, or Mayo Medical School

Exclusion Criteria:

* none