cyrilzakka/clinical-trials huggingface dataset:
"IONTOPHORESIS vs. PHONOPHORESIS" for Treatment of Subacromial Impingement Syndrome

The aim of this study was to compare the effects of iontophoresis and phonophoresis applications added to conventional treatment on pain, range of motion, disability, and functional status in the shoulder region in patients with subacromial impingement syndrome.

Randomization: Forty-seven patients were assessed, and 43 completed the study in this randomized trial. The participants were divided into two groups (Iontophoresis:22 and Phonophoresis:21) using the online randomization software (www.randomizer.org). All patients gave written informed consent after being verbally informed about the study.

Assessment Period: Assessments were conducted twice, at the start and after completion of the 10-session treatment program.

Session Period: All treatment programs were delivered five days per week for two weeks. The total number of sessions was ten.

Analysis: The statistical analysis was performed using version 21 of the Statistical Package for the Social Sciences (SPSS).To verify normal distribution, the Shapiro-Wilk test and histogram curves were utilized. Descriptive statistics for parametric variables included mean, standard deviation, and percentage. Since the data exhibited normal distribution, independent sample T-tests were used for group comparison while paired sample T-tests were used to detect changes within the group. The significance level of p\<0.05 was deemed acceptable for all analyses. For variables with nominal assessments, data were analyzed utilizing Yates Continuity Correction and Fisher's exact chi-square test.

The post hoc power of the study was calculated using Gpower 3.1.9.1 software. The resting VAS scores was taken as reference. In this context, Cohen's effect size was calculated as 1.00. When the alpha error was accepted as 5%, and effect size was 1.00, the post hoc power was found to be 94.27%.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with Stage I-II SIS
* The ages between 18 and 65 years

Exclusion Criteria:

* Having underwent shoulder surgery,
* Participated in a shoulder-related treatment program within the previous six months,
* Failed to adhere to the treatment program by 70% or more
Pregnancy Subsequent to Ventral Hernia Repair

We will examine the outcome of ventral hernia repair with subsequent pregnancy


Eligibility Criteria:
Inclusion Criteria:

* History of ventral hernia repair with subsequent pregnancy
* Born between January 1 1955 and January 1 1995

Exclusion Criteria:

* Registered in the Danish Hernia Database with a non-valid ID-number, i.e. non-Danish resident.
The Visuo-attentional Mediator of Social Facilitation

Social psychology has long established that the mere presence of others influences the investigator's individual behavior and performance. "Social facilitation" refers to any improvement or deterioration of performance due to the presence of others. For more than a century, social psychology has acquired a solid knowledge of the principles governing this fundamental form of social influence.

But the underlying mechanism of social facilitation remains debated, as behavior alone cannot identify it with certainty. This major unresolved problem makes it particularly difficult to translate laboratory results on social facilitation into real applications in areas such as school or work, where others are ubiquitous. The purpose of this study will therefore be to identify the mediator of social facilitation.


Eligibility Criteria:
Inclusion Criteria:

* Male or female
* Aged 18 to 35 years old
* Signed written informed consent
* Insurance coverage

Exclusion Criteria:

* Neurological or psychiatric or ophthalmological disorder
* Non-stabilized medical condition
* Ongoing treatment with drugs that affect the central nervous system

  * Uncorrected visual inadequacy
  * No fluency in French reading
  * Pregnant and / or breastfeeding woman, this exclusion criterion will be sought by questioning the subject
  * Subject commonly in care in a health or social facility for purposes other than that of research
  * Subject under guardianship
  * Subject deprived of liberty by a judicial or administrative decision
  * Incompatibility with the Magnetic Resonance Imaging (MRI) examination determined by answering the following questions:
* Carrier of a neurological stimulator, cardiac (battery) or defibrillator
* Carrier of a cardiac prosthesis (valve, stent ...) or vascular
* Holder of intracranial clips or clamps (staples)
* Carrier of a cerebrospinal fluid bypass
* Presence of metal chips in the eyes
* Metal prosthesis carrier (teeth, knees)
* Pump carrier or infusion system
* Presence of metal tattoo near the head
* Presence of permanent makeup
* Claustrophobia or respiratory disorders
Lymph Node Staging System With a Novel Concept for Gastric Cancer: a Hybrid Type of Topographic and Numeric Ones

For staging the status of lymph node metastasis in gastric cancer, typographic based staging system was applied until last decade, especially in Eastern countries. However the old typographic lymph node staging system in gastric cancer was too complicated and less accurate for predicting the prognosis. Now the numeric based lymph node staging system is used in both East and West, but it include problems: no information on the anatomical extent of the disease, preoperative lymph node staging is nearly impossible, failure to provide an appropriate treatment plan, cannot represent the extent of lymph node dissection. We designed simple and specifically representing the anatomic extent of the disease for staging the status of lymph node in gastric cancer. Thus we compared its prognostic performance of this new staging system with those of the current TNM 7th edition of AJCC/UICC.


Eligibility Criteria:
Inclusion Criteria:

* patients were pathologically confirmed as primary gastric cancer
* patients underwent gastrectomy with curative intent.

Exclusion Criteria:

* Patients underwent minimally invasive surgery
* patients with any distant metastases including peritoneal seeding and para-aortic LNs metastasis)
* when the location of lymph nodes were not divided
* patients underwent chemotherapy preoperatively
* patients had metastatic lymph nodes with unclear location
Awake-Prone Positioning Strategy for Hypoxic Patients With COVID-19

This study aims to determine if a strategy of recommending prone (on stomach) positioning of patients positive or suspected positive for coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, but not mechanically ventilated, Is feasible in the inpatient setting. This study will be performed as a pragmatic pilot clinical trial to gain information relevant to the future conduct of a larger trial.

Severe acute respiratory syndrome coronavirus-2, SARS-CoV-2, the virus causing coronavirus disease 2019 (COVID-19) pandemic, has rapidly led to significant morbidity and mortality worldwide, primarily through lower respiratory tract involvement progressing from hypoxemia to acute respiratory distress syndrome. Novel approaches to improving oxygenation are urgently needed to limit aerosolization concerns and resource scarcity associated with intubation and, to a lesser extent, other forms of advanced respiratory support.

Prone positioning in mechanically ventilated patients with hypoxemic respiratory failure has been associated with improvement in oxygenation and mortality in patients with acute respiratory distress syndrome (ARDS). The prone position appears to provide more uniform lung perfusion, shifting ventilation to well-perfused lung segments and recruitment of dependent atelectatic regions of lung. Physiological alterations associated with the prone position would foreseeably also apply to spontaneously breathing patients and evidence from small observational studies suggests that prone positioning in non-intubated patients is feasible associated with improvement in oxygenation. However, it remains unknown if a prone ventilation strategy is truly beneficial for non-intubated hypoxic Covid-19 patients, and this question has stimulated interest in the conduct of rigorous randomized controlled trials (RCT).

However, the awake prone strategy is a complex medical intervention with multiple implementation nuances such as adoption, feasibility, and tolerability that may affect successful conduct of a definitive RCT. In order to increase the likelihood of a successful future RCT, the investigators will conduct the APPS pilot study. The overall aim of the APPS pilot trial was to assess feasibility and important contextual factors for a large RCT to compare the clinical effectiveness of an Awake-Prone Positioning Strategy (APPS) for respiratory support versus usual care alone for hypoxic adults with Covid-19.

Eligibility Criteria:
Inclusion Criteria:

* hospitalized patients with positive COVID testing during hospitalization or 7 days prior OR Hospitalized with suspected COVID pneumonia
* room air oxygen saturation \<93% or oxygen requirement \> or equal to 3 Liters per minute

Exclusion Criteria:

* unable to turn self, spinal instability, facial or pelvic fractures, open chest or open abdomen, altered mental status, anticipated difficult airway, show signs of respiratory fatigue, or receiving end-of-life care
Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study

Lymphocytic thyroiditis is the most common autoimmune disease, usually affecting young women. Although the aetiology and pathogenesis remain obscure, the most widely accepted hypothesis is an interaction between a genetic predisposition and an environmental trigger factor such as viral infection. Parvovirus infections have been proposed as trigger factors for Hashimoto's thyroiditis and Graves' disease.


Eligibility Criteria:
Inclusion Criteria:

* Graves' disease :patients treated for Graves' disease, the diagnosis date less than 4 months
* Control : patients cared for nodules or goiter

Exclusion Criteria:

* Patients undergoing immunosuppressive therapy including corticosteroids
Intra and Inter- Observer Reproducibility of Ankle Dorsiflexion Measure With a New Tool

The Achilles' tendon is the largest and most resistant tendon in the body. When the triceps contracts, the Achilles' tendon is responsible for plantar flexion of the ankle. When the triceps are not contracted, the Achilles tendon is the main component in limiting dorsiflexion of the ankle, a major component of the gait pattern. The limitation of this dorsiflexion of the ankle can be caused by a shortening of the Achilles tendon.

This equine whose prevalence in the general population is greater than 50% according to Kowalski, appears to be a risk factor in many pathologies of the foot and ankle.

Currently, in clinical practice, the measurement of passive dorsiflexion of the ankle is empirically measured by the Silfverskiold test. However, the definition of a retraction varies according to the authors, in particular because of the absence of normalization of the force applied on the forefoot, or of the absence of uniformization of the angulation applied. This research is based on the hypothesis that a new measurement tool would be more efficient and more reproducible for measuring dorsiflexion of the ankle.

The study includes the measure of dorsiflexion of the ankle with a new tool on volunteers. The measurement will be reproduced three times on each ankle in two positions, with a force applied by three different persons. The measurement will be automatically recorded then analyzed.

Eligibility Criteria:
Inclusion Criteria:

* Man or woman, aged 18 years and more
* Student at the IFMK school (Paris)
* Participant without any trauma at the Achilles' tendon
* Participant who has been given appropriate information about the study objectives and who has given his/her express written and informed consent prior to conduct any study-related procedures.

Exclusion Criteria:

* Participant with a traumatic history of one of the two Achilles tendons
* Participant whose physical and / or psychological health is severely impaired, which according to the investigator may affect the participant's compliance with the study
Airway Data Collection with the Entarik Feeding Tube System

The purpose of this study is to evaluate the airway detection performance of the Entarik Feeding Tube System, and to collect data when the Entarik Feeding Tube is in the Airway for device development.

The study is a prospective, single center, non-blinded, single arm study. Subjects who are scheduled to undergo an elective bronchoscopy procedure will have an Entarik Feeding Tube placed into the airway through an endotracheal tube under direct visualization while temperature and impedance data are collected by the Entarik monitor. Other data will be passively simultaneously collected through the Feeding Tube.

Eligibility Criteria:
Inclusion Criteria:

1. At least 18 years old.
2. Able to provide informed consent.
3. Adults scheduled to undergo a bronchoscopy procedure who will be intubated as part of the standard of care.

Exclusion Criteria:

1. Known major upper airway malformation.
2. Presence of clinically significant respiratory infection.
3. Known bleeding disorder.
4. Currently pregnant.
5. Current basilar skull fracture.
6. Known sensitivities or allergies to the feeding tube components.
7. Deemed unsuitable for enrollment in study by the investigator based on subject's history (e.g., active anticoagulation therapy) or physical examination.
Warfarin Versus Aspirin in Patients With Atrial Fibrillation and Chronic Kidney Disease

In this study, the investigators examine whether aspirin or warfarin is useful for atrial fibrillation patients with chronic kidney disease.

randomised open labelled prospective study

We enroll patients with CHADS2 score 1 non-valvular AF with chronic kidney disease, and analyze all thromboembolic event or major bleeding event during follow-up period. Warfarin group take dose adjusted warfarin (target INR 2.0-3.0) and aspirin group take aspirin 100mg daly.

Thromboembolic events: Ischemic stroke or systemic arterial occlusion Major bleeding: gastrointestinal bleeding or intracranial bleeding (code 430, code 431, code 432 by ICD-9-CM codes)

-\> Only the first event of each case will be used for the analysis

Eligibility Criteria:
Inclusion Criteria:

* CHADS2 score 1 nonvalvular atrial fibrillation patients with chronic kidney disease

Exclusion Criteria:

* HAS-BLED ≥30
* History of syncope or seizure within 1 year
* History of major bleeding event within 6 months
* BP\>180/100
* Abnormal prothrombin time
* Hypersensitivity of aspirin or warfarin
* Folstein mini mental state examination score \<26
* Taking or had taken other anticoagulants
Study Comparing the Safety and Efficacy of IDP-120 Gel and IDP-120 Vehicle Gel in the Treatment of Acne Vulgaris

study designed to assess the safety, tolerability, and efficacy of IDP-120 Gel and IDP-120 Vehicle Gel

This is a multi-center, randomized, double-blind, vehicle-controlled, 12-week study designed to assess the safety, tolerability, and efficacy of IDP-120 Gel and IDP-120 Vehicle Gel at Weeks 2, 4, 8, and 12. To be eligible for the study subjects must be at least 9 years of age and have a clinical diagnosis of moderate to severe acne

Eligibility Criteria:
Inclusion Criteria:

1. Male or female at least 9 years of age and older;
2. Written and verbal informed consent must be obtained. Subjects less than age of consent must sign an assent for the study and a parent or a legal guardian must sign the informed consent (if subject reaches age of consent during the study they should be re-consented at the next study visit);
3. Subject must have a score of 3 (moderate) or 4 (severe) on the Evaluator's Global Severity Score (EGSS) assessment at the baseline visit;
4. Subjects with facial acne inflammatory lesion (papules, pustules, and nodules) count no less than 20 but no more than 50;
5. Subjects with facial acne non-inflammatory lesion (open and closed comedones) count no less than 25 but no more than 100;
6. Subjects with two or fewer facial nodules

Exclusion Criteria:

1. Use of an investigational drug or device within 30 days of enrollment or participation in a research study concurrent with this study;
2. Any dermatological conditions on the face that could interfere with clinical evaluations such as acne conglobata, acne fulminans, secondary acne, perioral dermatitis, clinically significant rosacea, gram-negative folliculitis, dermatitis, eczema;
3. Any underlying disease(s) or some other dermatological condition of the face that requires the use of interfering topical or systemic therapy or makes evaluations and lesion count inconclusive;
4. Subjects with a facial beard or mustache that could interfere with the study assessments;
5. Subjects with more than two (2) facial nodules;
6. Evidence or history of cosmetic-related acne
Short Term Effect of Post Surgical Treatment of Mirror Therapy of Phantom Limb Pain

The aim of the study is the measurement of the short term effect of post surgical mirror therapy concerning pain intensity and frequency of patients with upper or lower amputation in comparison to standard occupational or physical therapy. The hypothesis is that patients in the intervention group (mirror therapy) suffer significantly less from phantom limb pain and pain attacks within a follow-up period of 4-8 weeks.

Aim:

* Measurement of the short term effect of post surgical/ post-operative mirror therapy concerning pain intensity of patients with upper or lower amputation in comparison to standard occupational/ physical therapy
* Hypothesis: patients in the intervention group (mirror therapy) suffer from significant less phantom limb pain and a lower pain frequency within a follow-up period of 4-8 weeks

Methods:

* Design: multicenter, prospective, randomized controlled trial
* Participants: 70, 35 per intervention and con-trol group
* Intervention group: treatment sessions of 60 minutes with mirror therapy over a period of 14 days starting directly post surgical (24-48 hours)
* Control group: receive treatment session of 60 minutes with the same treatment frequency over a period of 14 days
* Measurement tools:

Primary objectives

* pain intensity (11 point NRS, phantom limb in-tensity)
* pain frequency (amount of pain attacks) Secondary objectives
* diary
* daily assessment of mirror and physical thera-py sessions
* analysis:
* in significant differences between the groups a covariance analysis will be performed
* comparison of medians

Eligibility Criteria:
Inclusion Criteria:

* major amputation of lower and upper body
* phantom pain, or pain attacks in combination with a treatment wish
* age of 18 years
* signed informed consent
* linguistic and cognitive comprehension

Exclusion Criteria:

* bilateral amputation
* major neurologic comorbidities (stroke, Parkinson disease)
* morbidities of the contralateral side with functional limitations
* experience with long term standardised mirror therapy
* internal comorbidities (pAVK)
* psychological comorbidities
Prevalence of Hemorrhagic Myocardial Infarction in the United States

Registry analysis for prevalence of hemorrhagic myocardial infarction in the United States


Eligibility Criteria:
Inclusion Criteria:

* Acute Myocardial Infarction - STEMI Primary PCI Availability of lab parameters and/or CMR
Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study

The CORRONA CERTAIN Sub-study of the Consortium of Rheumatology Researchers of North America, Inc. is a Sub-study of the CORRONA Data Collection Program.

The CERTAIN Sub-study is designed to systematically collect and document use patterns, effectiveness, comparative effectiveness and safety of biologic agents used in the management of Rheumatoid Arthritis (RA).

Biologic therapies (including biologic medications like Enbrel, Humira, Remicade, Cimzia, Simponi, Actemra, Rituxan and Orencia) have changed the treatment of RA, but the differences in safety and/or effectiveness of each biologic therapy are not all known. We are doing this study in order to try to see if one or more of these treatments are better than the others. The use of databases like the CORRONA Organization database gives us information that helps us to understand why such drugs are used, reasons for starting or stopping drugs, for whom they are prescribed, and to monitor changes in patients' abilities to perform daily activities and gather information on family or social history.

Eligibility Criteria:
Inclusion Criteria:

* The CORRONA CERTAIN Sub-study is particularly focused on understanding the effectiveness and safety of biologic medications. Male and female patients, who

  1. are at least 18 years of age;
  2. have a documented diagnosis of RA by their treating rheumatologist;
  3. have at least moderate disease activity; and
  4. are initiating a biologic agent that has not be used for their treatment in the past are eligible to participate.

     Moderate disease activity is defined by a CDAI score greater than 10.

     Exclusion Criteria:

     Disease other than RA that do not meet the inclusion criteria
INVESTIGATION AND COMPARISON OF THE EFFECTS OF POSTURE EXERCISES ON DYSFUNCTION, POSTURE AND BALANCE IN INDIVIDUALS WITH POSTERIOR EDENTULOUS AND FULL-TOOTHED TEMPOROMANDIBULAR DISORDER

The aim of this study is to investigate the relationship between neck posture and balance in patients with posterior edentulous and full-toothed temporomandibular disorder and to compare the effectiveness of the physiotherapy program to be applied.

The study was planned as a quasi-experimental controlled study. A total of 26 patients with temporomandibular disorder, aged between 18-70 years, 13 of whom were in the Posterior Edentulous Group (PDG) and 13 were in the Fully Toothed Group (TDG), were included. Posture exercises and manual therapy were applied to both groups twice a week for six weeks. Mandibular range of motion, pain, muscle strength, deep neck flexor endurance, flexibility, shortness, range of motion (ROM), pressure pain threshold (BAE), psychological state, posture and balance were evaluated before and after exercise.

The results of the study showed that six weeks of postural exercises and manual therapy provided significant improvement in all values (p\<0.05). A significant difference was found in pain, muscle strength, ROM, BAE and balance in PDG compared to TDG (p\<0.05).

The results of the study showed that symptoms can be improved by giving posture exercises in patients with tempromandibular disorder. It was concluded that the improvement in PDG was higher than in TDG.

Eligibility Criteria:
Inclusion Criteria:

* Being diagnosed with Myofascial Temporomandibular Disorder according to The Research Diagnostic Criteria for Temporomandibular Disorders
* Complaining of head or neck pain
* Having temporomandibular joint pain for at least 3 months
* Not having used an intraoral plaque before
* Able to follow the treatment protocol regularly
* Ability and willingness to communicate verbally

Exclusion Criteria:

* Being positive for COVID-19
* Sports injuries
* Presence of trauma
* Whiplash
* Degenerative changes
* Signs or symptoms of disc displacement, osteoarthrosis or osteoarthritis of temporomandibular joint
* Post-operative conditions involving the cervical or temporomandibular region
* Burn involving the cervical region and the temporomandibular region
* Patients using analgesics or muscle relaxants up to 8 hours before the physical therapy procedure
* Those with hypermobility in cervical movements
* Those who have received physiotherapy or other treatment from the head / neck area in the last 12 months
* Acute infections or any systemic disorder
* Osteoporosis