cyrilzakka/clinical-trials huggingface dataset:
Investigating the Mortality and the Morbidity Impact of Oral Polio Vaccine at Birth

Our group has discovered that routine vaccinations in childhood may have non-specific and sex-differential effects on overall mortality. The effects are so large that they may have marked effects on overall mortality and seriously distort female-to-male mortality rates in high-mortality settings. We recently experienced periods during which oral polio vaccine (OPV) was lacking. Hence, some children did not get the recommended OPV at birth. We were following all infants as a part of a vitamin A supplementation trial. Surprisingly, we discovered that not receiving OPV was associated with significantly lower mortality in boys, but not in girls. We bled a subgroup of the children. Receiving OPV at birth significantly dampened the immunological response to BCG given at birth in both sexes. Based on these observations, receiving OPV at birth may have two negative effects, first, it may increase male mortality, and second, it may interfere with immunity against tuberculosis. OPV at birth is given for logistic reasons, to boost polio immunity. There have been no polio cases in Guinea-Bissau for the last 10 years. Hence, there is every reason to test in a randomised trial whether not receiving OPV at birth is associated with 1) mortality, morbidity and growth and 2) immunological response to BCG.


Eligibility Criteria:
Inclusion Criteria:Normal birth weight, no overt illness or gross malformations -

Exclusion Criteria:

-
Mulligan's Bent Leg Raise Technique in Healthy Females

To determine the effects of mulligan's bent leg raise technique on hamstring flexibility and lumber spine mobility in healthy females

Flexibility is a pivotal constituent of the physical fitness and held as an integral aspect that capacitate the person to move smoothly and safely. Although the flexibility of all the muscles of the body is essential for normal human function, the flexibility of hamstring muscle is much emphasized. Investigations suggest adequate flexibility of the Hamstring muscles is compulsory for a healthy lower back. Lack of hamstring muscles extensibility conditions a decrease of pelvic mobility. This invariably leads to biomechanical changes in the pressure distribution of the spine and consequent spinal disorders.

This study will be a randomized control trial and will be conducted in health sciences collage in Bahawalpur. The study will be completed within the time duration of six months. Convenient sampling technique will be used to collect the data. The sample size of 48 patients will be taken in this study to find the Effects of Mulligan's bent leg raise technique on hamstring flexibility and lumber spine mobility in healthy females. Patient will be divided into two groups. Static Stretching will be given to both group as a baseline treatment. (Group A will be treated with Mulligan's bent leg raise techniques and static stretching Group B will be treated with static stretching only. Participants will be assessed for hamstring tightness with Active Knee Extension Test (AKET) and readings will be noted and lumbar mobility will be assess using Modified Schober Test (MMST). Assessments will be done at baseline and post intervention on 5th and 10th day. Intervention will be given 5 days per week for two weeks. Data will be analyzed on SPSS 25.

Eligibility Criteria:
Inclusion Criteria:

* Only healthy females will be included.
* Age 18-24 years.
* BMI normal
* Hamstring muscle tightness -90-90 hip active knee extension test positive (AKET).

Exclusion Criteria:

* Any traumatic and infectious condition involving lower limb.
* Pathologies and deformities related to knee and hip joint.
* Any neurological symptoms affecting the lower limbs.
* Subjects performing regular exercises or stretching.
Accuracy of a Mobile Sensor-Based System for the Detection of Chemotherapy Toxicity in Older Adults With Cancer in a Developing Country

Patients with cancer in developing countries face considerable challenges in obtaining access to care due to a lack of human resources and infrastructure. This is particularly pressing for vulnerable populations such as older adults. In this setting, many patients receiving chemotherapy are unable to report the presence of toxicities, and adverse events can go unnoticed for considerable amounts of time. The goal of this study is to assess the accuracy of an objective patient-centered measure of physical function (the number of steps taken per day measured using an accelerometer-equipped smartphone) for the remote detection of chemotherapy toxicity in older adults. This study builds on a pilot trial showing that monitoring older patients remotely utilizing an accelerometer-equipped smartphone is feasible and acceptable, and that a decline in the number of steps detected using the device can be an early sign of chemotherapy toxicity. The hypothesis of this study is that a decline in the number daily steps from a prechemotherapy baseline, measured using an accelerometer-equipped smartphone, will be accurate for detecting chemotherapy toxicity in older adults with cancer. This study will evaluate the ability of a patient-centered measure (a decline in the number of daily steps compared with a pre-chemotherapy baseline) to identify the presence of clinically-significant chemotherapy-related toxicity in Mexican older adults with cancer starting first line chemotherapy. Patients will be provided with an accelerometer-equipped smartphone with an installed pedometer application. Baseline steps per day will be obtained and recorded before starting chemotherapy. The patients' steps will be monitored daily for the first three chemotherapy cycles and compared with baseline recordings. Patients will be contacted daily and chemotherapy toxicity will be assessed by a physician. If significant toxicities are identified, the patient will be prompted to seek medical attention. The optimal cutoff point for detecting chemotherapy toxicity utilizing a decline in the number of daily steps will be chosen and validated. The adherence and satisfaction with the intervention will also be evaluated. This study could improve current methods and transform the way in which cancer care is delivered by demonstrating that a simple patient-centered measure obtained using a commercially available smartphone can aid in the accurate identification of clinically significant toxicities among a vulnerable population such as older adults with cancer.


Eligibility Criteria:
Inclusion Criteria:

* ≥65 years old
* Any solid tumor
* Starting first-line chemotherapy
* Adjuvant, metastatic or recurrent setting
* Any socioeconomic and educational level

Exclusion Criteria:

* Patients with walking disability
* Bedridden patients (ECOG 3)
* Second or subsequent line of chemotherapy
* Inpatients
* Patients receiving radiation concomitantly with chemotherapy
Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes

Type 1 diabetes is associated with many longterm complications as retinopathy,neuropathy and nephropathy. Recently, several studies have linked type 1 diabetes to bone fragility.Studies conducted on patients with type 1 diabetes have concluded that bone is negatively affected in type 1 diabetes with impaired bone density,increased fracture risk and impaired bone turnover markers.


Eligibility Criteria:
Inclusion Criteria:

* childern and adolsecents below 16 years of age diagnsed with type 1 diabetes for at least 1 year age and sex-matched control childern and adolsecents will be included

Exclusion Criteria:

* childern and adolescents with congenital bone disease, those with disorders of the parathyroid gland and those with chronic kidney disease.
99mTc Labeled FAP Targeted Molecular Probe in Early Diagnosis of Tumors

At present, radiopharmaceuticals targeting FAP have been developed for the diagnosis and treatment of various tumors. Considering the problems of fast tumor tissue clearance and short retention time in small molecule FAP inhibitors based on quinoline rings, this project optimized their ligands and developed a new FAP targeted technetium labeled molecular imaging probe for SPECT/CT imaging research to evaluate its safety in clinical application and its effectiveness in tumor diagnosis.


Eligibility Criteria:
Inclusion Criteria:

* Voluntary subjects, patients or their legal representatives sign informed consent;
* Volunteers are of any gender and aged between 18 and 75 years old, including the cut-off value;
* Other imaging methods found tumor occupying;
* Patients with pre-treatment tumors for whom surgery or biopsy may be performed to obtain final pathological results.
* Kidney glomerular filtration rate(GFR)\>50 ml/min, effective renal plasma flow(ERPF)\>280 ml/min, platelet count (PLT) \>75 000/μL, white blood cell (WBC) \>3000/μL, alanine aminotransferase ALT, aspartate aminotransferase AST less than 3 times the normal value.

Exclusion Criteria:

* People who have a history of allergy to similar drugs , allergic constitution or are currently suffering from allergic diseases;
* Is conducting clinical research on other drugs, or has participated in clinical research on any drugs (excluding vitamins and minerals);
* Have other clinical problems that are difficult to control (such as hepatitis C virus infection or active hepatitis B, or other serious chronic infections and serious mental, neurological, cardiovascular, respiratory and other diseases);
* Obvious abnormal liver and kidney function, GFR less than 50 ml/min;
* Tumor load is greater than 50%, or there is obvious spinal cord compression;
* The expected survival period is less than half a year; Chemotherapy was performed within 6 months.
* Have severe acute concomitant diseases or serious refractory mental disorders;
* Pregnant and lactating women (where pregnancy is defined as a positive urine pregnancy study);
* Patients whose physical condition is not suitable for radiological examination;
* Other situations deemed inappropriate by the investigator to participate in the trial.
Recovering Arm Function in Chronic Post-stroke Patients Using Combined HD-tDCS and Virtual Reality Therapy

The study aims to determine the added value of combining high-definition transcranial direct current stimulation (HD-tDCS) in a rehabilitation program based on virtual reality therapy (VRT) to potentiate the effects on neuroplasticity and further improve functional recovery of the arm in chronic stroke patients.

Stroke remains the leading cause of acquired disability in France. Moreover, even after the first 3 months of intense arm rehabilitation, 80% of chronic stroke patients don't use their paretic arm in activities of daily living.

To this day, despite notable developments, techniques of rehabilitation of the arm for chronic stroke patients are still insufficient. In this context, two promising stroke rehabilitation techniques are to be considered:

* Virtual reality-based systems provide specific, intensive, repetitive and motivational therapy with real-time feedback of movement and performance which can promote activity-dependent brain neuroplasticity, and therefore functional arm recovery. Thus, virtual reality therapy (VRT), in addition to usual rehabilitation, would improve the function of the arm more effectively as well as daily activities.
* Non-invasive transcranial direct current stimulation (tDCS) uses constant low intensity (2 mA) continuous electrical currents to modulate the excitability of cortical neurons. Because of its greater focality of neuromodulatory effect that promotes brain neuroplasticity, anodal HD-tDCS to the lesioned hemisphere can improve functional arm recovery after a stroke. In addition, the combined use of the HD-tDCS with a rehabilitation modality, such as constraint induced movement therapy, would potentiate the combined effects of both techniques.

Therefore, the investigators hypothesize that the combination of HD-tDCS in a rehabilitation program based on VRT would potentiate the effects on neuroplasticity and would further improve functional recovery of the paretic arm in chronic stroke patients

Eligibility Criteria:
Inclusion Criteria:

* Patient aged 18 to 90
* Patient with more than 3 months of a first cerebrovascular accident whatever the aetiology
* Patient with paresis of the upper extremity (FM-UE ≥ 15)

Exclusion Criteria:

* Failure to collect written informed consent after a period of reflection
* Not be affiliated with a French social security scheme or beneficiary of such a scheme
* Major deficit of the upper extremity (FM-UE \<15)
* History of epilepsy
* Presence of a pacemaker or a metallic object implanted in the head
* Pregnant or lactating
* Severe neglect or attention deficit disorder (omission of more than 15 bells in the Bell's test)
* Severe cognitive impairment (Mini Mental Score \<24)
* Aphasia with impairment of understanding (Boston Aphasia Quotient \<4/5)
* Under guardianship or curatorship
* Protected by law
Seroimmunity 2007 and Sub Study of the Swedish Population Regarding Vaccine Preventable Disease

This is a randomized cross-sectional study of the Swedish population. Blood samples will be collected from a subpopulation in order to estimate the age specific sero-prevalence of the Swedish population for diseases included in the National Immunization Program (NIP), and to affirm the population's protection against polio. To be able to recommend complementary immunizations to immigrated children, a sub study focusing on foreign born teenagers will also be done and compared to children of the same age born in Sweden.

Besides the main objectives stated in the summary, the study consists of:

Vaccine related objectives:

* To estimate the seroprevalence regarding vaccine preventable diseases in the cohort of children about to enter adulthood (as a "receipt" of the vaccination program's functionality), and thereby form a basis for decision-making regarding recommendations about continuous vaccination in adult age
* To evaluate the concentration of antibodies that full-term newborns receive from their mothers, and to estimate plausible consequences to optimize the schedule of the NIP for each vaccine preventable disease
* To, in different age groups, evaluate changes over time and concentration of antibodies compared to a study conducted in 1997
* To evaluate plausible changes in the seroprevalence, for instance among children, related to an increased use of combined vaccines
* To document the age-specific seroprevalence against other diseases that will be vaccine preventable before start-up of new vaccination program
* To estimate the population seroprevalence against certain diseases against which vaccines have been developed during recent years and that might be introduced into the vaccination program within a couple of decades

Method:

* Adults: one blood sample of 10 mL blood from vein in arm from each individual
* Children: one blood sample of 5-10 mL blood from vein or capillary in arm from each individual
* Cord blood: one blood sample of 10 mL cord blood will be collected from each newborn in connection with childbirth

The objectives of the sub study are:

* To conduct the same type of analysis on foreign born 14-16 year olds as on 14-16 year olds being born in Sweden
* To also examine the immunity and infection situation with regard to Hepatitis B
* To conduct the corresponding examinations and priorities among the 14-16 year olds born in Sweden serving as control group

Eligibility Criteria:
Inclusion Criteria:

* informed written consent (both groups)
* immigrated to Sweden after 6 years of age from a country with polio vaccination coverage \< 85 % (Sub study group)
* living and attending school in Stockholm, Gothenburg or Malmoe (Sub study group)
A Study of SPY001-001 in Healthy Volunteers

This is a Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose, first in human safety, tolerability, and pharmacokinetic study of SPY001-001 in healthy participants.


Eligibility Criteria:
Inclusion Criteria:

* Healthy men and women
* Willing and able to attend the necessary visits to the CRU, comply with all testing requirements, remain at the study site unit for the duration of the confinement period and return for the outpatient visits

Exclusion Criteria:

* Participation in more than one cohort
* Evidence of clinically significant abnormality or disease
* Known history of illicit drug use or drug abuse, harmful alcohol use or alcoholism, and/or smoking or nicotine-containing product use within 3 months prior to the first dose of study drug
* History of severe allergic reactions or hypersensitivity
* Donation or loss of \>1 unit of whole blood within 1 month prior to dosing
Effect of Garlic Extracts on Changes in Cerebral Blood Flow

The purpose of this study is to assess the safety and efficacy of Garlic extracts for improving of cerebral blood flow.


Eligibility Criteria:
Inclusion Criteria:

1. Healthy adults 19 years of age or older as of the screening date
2. Those with no history of treatment for hypertension within the last 3 months
3. A person who voluntarily decides to participate and agrees in writing to abide by the precautions after hearing and fully understanding the detailed explanation of this study

Exclusion Criteria:

1. Those with systolic blood pressure of 160 mmHg or higher or diastolic blood pressure of 100 mmHg or higher
2. Those who have had a stroke, myocardial infarction, percutaneous coronary angioplasty or surgery for coronary angioplasty within the past 6 months
3. Persons with acute and severe cardiovascular diseases such as heart failure, myocardial infarction, and stroke
4. Those with acute/chronic inflammation such as cancer, rheumatic disease, autoimmune disease, gastrointestinal disease, etc.
5. Those who have a history of gastrointestinal diseases (eg Crohn's disease) or gastrointestinal surgery (except simple appendicectomy or hernia surgery) that may affect the absorption of the product for human application testing
6. Persons who have taken prohibited concomitant drugs within the last 3 months
7. Persons with a history of clinically significant hypersensitivity reactions to drugs and health functional foods
8. Those who have received antipsychotic drug treatment within 2 months before the screening test
9. Persons with a history of drug or alcohol abuse
10. Pregnant or lactating women
11. When women of childbearing potential of childbearing potential do not accept the implementation of appropriate contraceptive methods (except for women who have undergone sterilization)
12. Subjects who have participated in health functional food related research or clinical trials within the last 3 months
13. In case the principal investigator judges that it is not appropriate to participate in this study
Near-Infrared Fluorescence Guided Robotic Pulmonary Segmentectomy for Early Stage Lung Cancer

Lungs are made up of individual lobes. When a lung cancer tumour is detected in one of these lobes, surgeons typically perform a Lobectomy. A Lobectomy is the surgery most commonly done to treat early-stage lung cancer and requires removal of an entire lobe of the lung, which removes a large amount of lung tissue For patients with small tumours saving as much healthy lung tissue as possible is important. Each lobe of the lung has smaller sections called segments. When a lung cancer is in one of these segments, it is possible to remove that segment, without removing the entire lobe. This surgery is called a segmentectomy. Compared to a lobectomy, a segmentectomy saves a larger amount of healthy lung tissue.

With the advances in screening technology for lung cancer tumours, an increasing amount of very small lung cancer tumours are being found, and the demand for segmentectomy is increasing. A segmentectomy is a hard surgery to perform robotically because it is difficult to view the tissue lines that separate each segment within the lobe. As a result, it is difficult for the surgeon to see exactly which pieces of tissue should be removed. Because of these challenges, many patients having robotic surgery will have a lobectomy, even if a full lobectomy is not needed.

Near-Infrared Fluorescence (NIF) using indocyanine green (ICG) fluorescent dye is a recent advancement in the robotic platform of robotic surgery. The surgeon will view the CT scan to determine which segment the tumour is located in. Once identified, the surgeon will isolate the segment by cutting off the blood supply to that segment. Then ICG will be injected into a vein. It is expected that the entire lung, except the isolated segment, which will remain 'dark' as it was isolated from blood supply, will fluoresce, giving off a green hue when viewed with the da Vinci Firefly camera. The surgeon will identify 'dark' segment, and will remove it. A pathologist will examine the excised tissue to ensure that the tumour was removed in its entirety. Once confirmed, the surgeon will end the procedure. If the pathologist determines that the segment removed did not contain the entire tumour, then the surgeon will perform a routine lobectomy. This ensures patient safety and confirms that all participants will have the entire tumour removed from their lung.


Eligibility Criteria:
Inclusion Criteria:

1. Age \> 18 years
2. Tumor size \<3 cm
3. Clinical Stage 1 Non-Small Cell Lung Cancer (NSCLC)
4. CT-imaging confirming that the tumour is confined to the one broncho-pulmonary segment, rendering the patient a candidate for segmental resection.

Exclusion Criteria:

1. Hypersensitivity or allergy to ICG, sodium iodide or iodine
2. Women who are currently pregnant or are breast feeding; or women of child bearing potential who are not currently taking adequate birth control.