cyrilzakka/clinical-trials huggingface dataset:
Transurethral Versus Percutaneous Endoscopic Management of Bladder Stones in Boys

To compare safety and efficacy of trans urethral and per cutaneous approaches in endoscopic management of bladder stones in boys younger than 14 years

Pediatric urolithiasis remains endemic in developing nations, affecting children at ages less than 1 year to adolescence. The prevalence rate is high at 5% to 15% compared with 1% to 5% in developed countries. Recent studies have shown that the percentage of bladder stones in pediatric urolithiasis is 30%.

Open cystolithotomy has been the traditional modality to treat bladder stones. It has the inherent problems of a long scar, prolonged catheterization and hospitalization and risk of wound infection .The advent of improved endoscopic techniques in the form of gradual decrease in endoscopic sizes and the development of effective lithotripters have made trans urethral endoscopic management of bladder stones feasible. Excellent stone-free rates with trans urethral lithotripsy with minimal complications make it a preferred treatment option . However, in children especially boys, the small caliber of urethra raise concerns about the ability of stone fragments clearance and the possibility of iatrogenic urethral stricture occurrence. This renders trans urethral cystolithotripsy to be more difficult and unfavorable .

Per cutaneous cystolithotomy (PCCL) can be a safe alternative with low morbidity and complication rate. It has been performed safely for bladder stones up to 5 cm in size. This procedure may carry many advantages in the form of short operative time, more feasible stone fragments retrieval and less need for stone disintegration with its possible sequel as mucosal perforation or stone escaping inside the bladder that prolong the operative time.

On the other hand PCCL has important disadvantages such as the presence of an incision, the need to dilate a tract and the potential need for a urethral catheter or supra pubic tube. There are other reported complications including paralytic ileus, abdominal distention from escape of irrigating fluid into the abdominal cavity and urine leakage. It also carries a risk of bowel injury especially if there is a history of abdominal or pelvic surgery.

To the best of our knowledge, no previous prospective studies compared between per cutaneous and trans urethral approaches for endoscopic management of bladder stones in male children.

The aim of the study is to compare safety and efficacy of trans urethral and per cutaneous approaches in endoscopic management of bladder stones in boys younger than 14 years.

Eligibility Criteria:
Inclusion Criteria:

* Boys less than 14 yrs old age with bladder or urethral stones less than 3 cm.

Exclusion Criteria:

* Neurogenic bladder. Augmented bladder. Upper urinary tract stones that needs simultaneous ureteroscopy, PNL or ureteral stent insertion.

Bleeding tendency. Urethral stricture. Stone in fossa navicularis that can be extracted after meatotomy.
Study to Investigate the Causes of Fever in Children Living in Urban Dar es Salaam and Rural Ifakara

The goal is to improve the evidence-based management of fever cases seen in outpatient clinics in malaria endemic countries, through a better understanding of the value of accurate malaria diagnosis, and through an improved understanding of the other causes of fever in children. The objective is to describe systematically (as much as possible) the etiologies of fever in children in an urban and in a rural environment of sub-Saharan Africa.


Eligibility Criteria:
Inclusion Criteria:

* axillary temperature of 38°C or more
* first consultation for the present problem
* history of fever lasting for one week or less
* main complaint was not an injury or trauma
* no report of an antimalarial or antibiotic medicine taken during the previous week

Exclusion Criteria:

* severe malnutrition
* categorized as P1 (requiring immediate live saving procedures)
Long-term Outcomes of Endoscopic Papillary Balloon Dilation for 8-12mm Bile Duct Stones: a Prospective Study

The investigators prospectively evaluated long-term outcomes of ELBPD+EST for CBD stones up to 8-12mm.

EPBD+EST in patients with CBD stones up to 8-12mm appears to be associated with a very low (\<3%) rate of long-term stone recurrence. The efficacy of EPBD for 8-12mm stones warrants further exploration in randomized trials.

Consecutive patients with CBD stones up to 8-12mm successfully treated by EPBD+EST from September 2018 to August 2020 were prospectively followed for at least 12 months. CBD stone recurrence was defined as recurrent stones confirmed by ERCP during the follow-up period. The maximum diameter of the balloon used was 15mm.

Overall, 72 patients (mean age: 67 years, 52.8% males) were included, of whom 22 (30.5%) had multiple CBD stones, 23 (31.9%) had a history of cholecystectomy, 13 (18.1%) had a periampullary diverticulum and 22 (30.5%) had a previous EST. The mean CBD diameter was 11.6±1mm, whereas a tapered duct was noted in 7 (9.7%). Post-procedural bleeding occurred in one case, treated successfully a with a fully covered metal stent. Mild cholangitis occurred in two cases. No cases with perforation or PEP were observed. During a mean follow-up of 22.4±6.2 months (range 13-36), CBD stones recurred in 2/72 (2.7%).

EPBD+EST in patients with CBD stones up to 8-12mm appears to be associated with a very low (\<3%) rate of long-term stone recurrence. The efficacy of EPBD for 8-12mm stones warrants further exploration in randomized trials.

Eligibility Criteria:
Inclusion Criteria:patients with ELBPD+EST for CBD stones up to 8-12mm from September 2018 to August 2020 -

Exclusion Criteria: Patients with bile duct stones less than 8mm or more than 12mm.

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Virtual Rehabilitation and PNF in the Recovery of the Motor Function Post Stroke

The purpose of this study is to determine the effects of use the Nintendo Wii® (NW) and therapeutic exercises by the method Proprioceptive Neuromuscular Facilitation (PNF) in the recovery of the motor function of poststroke hemiparesis patients.

Randomised clinical trial (RCT) will be held in following the recommendations of the CONSORT (Consolidated Standards of Reporting Trials). This RCT have longitudinal and prospective feature, held at the Neurosciences Clinic located at the Clinic Professor Francisco Magalhães Neto the HUPES Complex / Federal University of Bahia from June 2015 until June 2016.

In the initial evaluation were obtained by a trained examiner and blinded to the allocation of participants, all personal data of all patients, as well as evaluations of balance and quality of life through specific validated scales:

1. Fugl Meyer scale (FMS);

The investigators employ an experimental program of therapeutic exercises for the PNF method and virtual rehabilitation with NW, for a period of two months, with sessions two times a week for 50 minutes (a total of 16 sessions).

Eligibility Criteria:
Inclusion Criteria:

* age between 18 and 80 years, of both sexes; neurological clinical diagnosis of stroke;
* owning grade 2-4 spasticity according to the Ashworth scale;
* hemiparetic patients after 6 months of onset of stroke;
* deficit moderate gait according to Functional Ambulation Classification (values ≥ 2).

Exclusion Criteria:

* score \<24 on the Mini Mental State Examination;
* other associated neurological diseases, as well as orthopedic and no visual or hearing impairment;
* participation in other rehabilitation programs.
Behavioral Therapy for Reduction in Smoking Craving

The objective of this pilot research is to investigate the effects of two behavioral smoking cessation programs on aspects of cue-induced cigarette craving, and to further investigate the neural bases of such effects.

The objective of this pilot research is to investigate the effects of two behavioral smoking cessation programs on aspects of cue-induced cigarette craving, and to further investigate the neural bases of such effects. The specific objectives of the study include 1) to investigate the effects of behavioral therapy on cue induced craving using a cognitive task and a fMRI paradigm 2) to pilot test questionnaires and study procedures, and 3) to gather preliminary estimates of the effect size of the novel behavioral therapy for smoking cessation in order to inform the design of a larger trial. A secondary goal of this research is 1) to determine the impact of two cognitive coping techniques on attentional bias to smoking related cues as measured by behavioral responses and patterns of neural activation and 2) to determine the impact of two cognitive coping techniques on cue-induced cigarette craving as measured by self-report and patterns of neural activation. Daily smokers desiring to quit smoking were randomized to one of two behavioral smoking cessation programs: (1) standard cognitive behavioral therapy or (2) mindfulness-based cognitive therapy. Participants completed questionnaires and a brief computer-based cognitive testing paradigm. Participants also underwent a fMRI scan at quit day (week 5). A randomly assigned subset of the participants (n= 18), underwent two additional scans at baseline (week 1) and end-of-therapy (week 8). The study has thus used self-report measures, cognitive testing (Stroop task), and fMRI (functional magnetic resonance imaging) assessments.

Eligibility Criteria:
Inclusion Criteria:

* Currently be cigarette smokers who desire to quit in the next 30 days (preparation phase).
* Subjects must smoke at least 10 cigarettes per day
* Must be at least 18 years old
* English speaking
* Able to read, understand, and complete a written questionnaire
* Must be willing to attend 8 sessions of behavioral therapy and perform daily home practice
* Must not currently be using pharmacologic therapy to quit
* Must also be willing to abstain from pharmacologic therapy for the duration of the study, which is 8 weeks from the time of enrollment.
* Only strongly right-handed subjects will be included

Exclusion Criteria:

* Pregnant women
* Have metal permanently in or on the body (aneurysm clips, permanent piercings, permanent dental work)
* Weigh over 300 pounds
* Known problem of claustrophobia
Mixed Chimera Allogeneic Transplantation From Matched Unrelated Donors For The Treatment Of Multiple Myeloma

The purpose of the study is to determine the toxicity and feasibility of non-myeloablative allogeneic hematopoietic cell transplants for multiple myeloma from unrelated donors.

The primary objective of the protocol is to evaluate the toxicity and tolerability of this mixed chimerism matched unrelated donor allogeneic transplant approach for patients with multiple myeloma. Response, toxicity, survival and graft-versus-host disease will be evaluated.

Eligibility Criteria:
Inclusion Criteria:a) Multiple myeloma which is responsive to therapy. Eligible patients may have early or relapsed disease. Patients must have Stage II-III disease or have progression after initial treatment of Stage I disease. Patients who have relapsed following autologous transplantation may be eligible for this protocol.

b) Age \<= 60 years. c) No prior therapy which would preclude the use of low-dose total body irradiation.

d) Patients must have their pathology reviewed and the diagnosis confirmed at Stanford University Medical Center. Patients with smoldering multiple myeloma, monoclonal gammopathy of unknown significance, or amyloidosis will be excluded from this study.

e) Patients must have a Karnofsky performance status \> 70%. f) DLCO \>= 60% predicted. g) ALT and AST must be \< 2X normal. Total bilirubin less than 2 mg/dl. h) Serum creatinine \< 2.0 or 24-hour creatinine clearance \>= 50 ml/min. i) Patients must be HIV negative. j) Pregnant or lactating women will not be eligible to participate. k) Patients must provide signed, informed consent. Exclusion Criteria:a) Severe psychological or medical illness b) Patients who have undergone prior allogeneic hematopoietic cell transplantation will not be eligible for this study.

c) Patients who have an HLA-identical sibling donor will be excluded
Prognostic Effect of Body Composition in Cancer Survivors

This study aims to evaluate the association between body composition and mortality risk among the US population based on data from the National Health and Nutrition Examination Survey (NHANES), a nationally representative cohort.


Eligibility Criteria:
Inclusion Criteria:

* Participants with cancer diagnosis beyond 18 years old.

Exclusion Criteria:

* Participants with missing cancer investigations and incomplete DXA body composition data were excluded from the study.
Real World Experience With Mogamulizumab in the Treatment of Cutaneous T-cell Lymphoma

This study is designed to describe the clinical activity and safety profile of mogamulizumab at standard dose in the treatment of CTCL patients in real world setting

Mogamulizumab (anti-CCR4) has been recently approved and reimbursed in Italy for the treatment of Cutaneous T-cell lymphoma (CTCL) after 1 previous systemic treatment based on the favourable results of the MAVORIC clinical trial. To date, no real-world data on significant series of patients treated routinely with mogamulizumab in clinical practice are available. As real-life data are essential to confirm the preliminary evidence displayed in phase III trials, this study aims at describing the clinical activity and safety profile of mogamulizumab at standard dose in the treatment of CTCL patients in real world settings.

Eligibility Criteria:
Inclusion Criteria:

* Confirmed diagnosis of CTCL according to the EORTC 2017 update criteria (Trautinger et al, Eur J Cancer, 2017)
* Age ≥18 years
* Have failed at least one previous line of systemic therapy
* Have received mogamulizumab in real life setting after the approval and reimbursement of the drug from the National Health System in December 2020
* Have received first dose of mogamulizumab between 01/01/2021 and 31/01/2023
* Have received mogamulizumab at the standard approved dose (1.0 mg/kg intravenously on days 1, 8, 15 and 22 of the first cycle and on days 1 and 15 of subsequent cycles)
* Availability of complete medical records.

Exclusion Criteria:

• Patients not meeting the above-mentioned inclusion criteria
Role of SGLT2I in Patients With Myocardial Infarction

Role of sglt2I in diabetic patients with myocardial infarction


Eligibility Criteria:
Inclusion Criteria:

1. Acute myocardial infarction patients
2. Type 2 diabetics.

Exclusion Criteria:

1. Patients undergoing coronary artery bypass grafting (CABG).
2. Severe valvular heart disease.
3. Contraindications of secondary medical preventive therapy for myocardial infarction, such as β-blockers, angiotensin-converting enzyme inhibitors (ACEI)/ angiotensin-converting enzyme inhibitors (ARBs), antiplatelets, and statins.
4. Previously used SGLT2i.
5. Severe hepatic and renal insufficiency.
Tissue Sample Collection From Patients With Fanconi Anemia

RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.

OBJECTIVES:

* Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute.
* Study repository tissue using a variety of molecular methods, including gene microarrays.
* Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia.

OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived.

PROJECTED ACCRUAL: Not specified.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Confirmed Fanconi anemia
* Confirmed malignant solid tumor
* Biopsy of tumor tissue available

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified
Health Promotion Model, Fertility Awareness, Preconception Knowledge and Attitude

The effect of education given to preconceptional women in line with the health promotion model on fertility awareness, preconceptional knowledge and attitude levels

The research is a randomized controlled trial. The research will conducted with 128 women (intervention group n=64, control group n=64). It will consist of women between the ages of 18-35 who applied to the community health unit of Güneysınır District Health Directorate between December 2024-May 2025.

Women who accept the research and are assigned to the intervention group will be given a five-day training to increase fertility awareness and preconceptional knowledge levels in line with the health promotion model. At the end of the fifth day, the Fertility Awareness Scale, Preconceptional Knowledge and Attitude Scale, and the Clinical Evaluation Form of the Health Promotion Plan for the Health Promotion Model will be applied to women who complete the training with a face-to-face interview technique. The women in the intervention group will be reached by phone at the end of the first and second months to remind them of their health promotion behaviors and to answer their questions and carry out follow-ups. At the end of the third month, women who have completed the training will be invited to the institution and the forms will be filled out again.

Eligibility Criteria:
Inclusion Criteria:

* Women between the ages of 18-35,
* Planning to get pregnant within a year,
* Literate,
* Can understand and speak Turkish,
* Agree to participate in the research.

Exclusion Criteria:

* Women who are pregnant,
* Women who are breastfeeding,
* Women who have been diagnosed with infertility,
* Women who have a history of chronic disease (hypertension, diabetes mellitus, hypothyroidism, etc.),
* Women who have a sexually transmitted disease (HIV, HPV, etc.),
* Women who have a physical disability,
* Women who have a psychiatric disease,
* Women who have a history of gynecological disease.
The Missouri Health Literacy and Diabetes Communication Initiative

Objective: to evaluate the efficacy of the American College of Physicians Foundation (ACPF) Diabetes Guide (Living with Diabetes: An Everyday Guide for You and Your Family) to improve diabetes self-management.

Study Sites: Nine Federally-qualified health centers or safety-net clinics at three sites in Missouri. Sites are urban (St. Louis), midsize (Columbia) and rural (Kirksville). Three FQHCs or safety net clinics are located at each of the sites.

Methods Overview and Design: A randomized controlled trial will be conducted. Patients will be recruited from identified health centers. As the intervention itself is directed to the clinic and not patient, the clinics will be randomly assigned to either 1) usual care (no treatment), 2) "Carve-In" - patients receive the Diabetes Guide and clinic staff follow-up and work with patients to create and complete action plans or 3)"Carve-Out" - patients receive the Diabetes Guide and a diabetes educator in Chicago follows up and works with patients to create and complete action plans. Recruited subjects will be administered a baseline assessment, and 3-month and 1-year follow-up assessments.

Sample: The investigators will recruit a total of 1,080 patients (n=120 per clinic) anticipating 80 percent retention through both follow-up assessments (final estimated number of patients = 720). Eligibility to participate will be defined as patients 1) ages 30 and older (to better represent disease distribution), 2) English or Spanish-speaking, 3) a confirmed (by chart) diagnosis of uncontrolled diabetes (HBA1c 7.0 or more).


Eligibility Criteria:
Inclusion Criteria:

* Uncontrolled diabetes patients (defined as HbA1c 6.0 or greater).
* 25 years or older
* English or Spanish speaking

Exclusion Criteria:

* Uncorrectable hearing or visual impairment
* Moderate to severe cognitive deficits
Stamford Group Family Nurture Intervention

The purpose of this current study is to investigate the efficacy of a group model of Family Nurture Intervention in ameliorating behavioral problems in preschool-aged children. The behavioral, neurobiological and clinical insights gained from this project may eventually lead to better treatment of emotional, behavioral, and developmental disorders. The investigator hypothesizes that the children who are treated with Family Nurture Intervention (FNI), which incorporates interactive touch with vocal soothing, and family practice in comforting, will show increased emotional connection and mother child co-regulation with better results in the outcome measures in the short term and long term.

There are several early intervention programs that are available for children with emotional, behavioral and developmental disorders, ranging from behavioral treatment and sensory exposure therapy to pharmaceutical treatments. Although improvements in behavior have resulted from these interventions, they are limited in numerous ways. They are usually time-consuming, both for the child and the teacher or clinician providing the intervention. In order to see an effect of the intervention, most children must engage in the intervention procedure for several years. Moreover, the effects of most current intervention procedures are minimal to moderate. Pharmaceutical prescriptions are often accompanied by undesirable side effects that may modulate behavior, emotion, and physiological functions. The behavioral, neurobiological, and clinical insights gained from this project may eventually lead to better treatment of emotional, behavioral and developmental disorders.

Eligibility Criteria:
Inclusion Criteria:

* Child is a singleton
* Mother can speak, read and write in English or Spanish
* Child is between the ages of 2-4 1/2 years at date of enrollment
* Mother is 18 years of age or older at the time of consent
* Child resides with mother
* Child demonstrates developmental deficit as measured by the Strengths and Difficulties Questionnaire (13 or higher on behavioral questions or 4 or less on prosocial questions)
* Mother and child deemed "emotionally unconnected" using the Welch Emotional Connection Scale (WECS) to score their five minute Welch Lap Test video
* Mother is able to commit to study schedule

Exclusion Criteria:

* The child has severe congenital anomalies or chromosomal anomalies including Downs syndrome and Cerebral palsy
* Child has a motor disability
* Mother sees or hears things that other people do not seem to see or hear
* Mother has trouble distinguishing whether something is real or part of imagination or dreams
* Mother is currently taking antipsychotic medications
* Mother or child have any medical conditions that might prevent them from participating in block play, mother holding child, or child sitting on mother's lap
* Mother has any current drug and/or alcohol abuse
* Mother is more than 4 months pregnant
* Mother is currently involved with Department of Children and Families
* The child has a diagnosis of Autism