cyrilzakka/clinical-trials huggingface dataset:
Effect of Thera Band Exercises on Adhesive Capsulitis Post Mastectomy

Breast cancer surgeries particularly mastectomy results in limited shoulder movement which can lead to arm, shoulder pain and stiffness. Females who underwent mastectomy have reported a significantly higher incidence of shoulder morbidity

Exercise therapy might help in reduction of pain and restoration of the range, coordination and control of movement in patients with adhesive capsulitis. Graded resistance exercises are effective in decreasing fatigue levels, enhancing functional capacity and muscle strength. Rehabilitation exercises which strengthen the scapular stability can be extremely beneficial in rehabilitation treatment of patients with shoulder pain and problems

Eligibility Criteria:
Inclusion Criteria:

* Age ranged from 40-60 years.
* 2nd stage of adhesive capsulitis,
* Shoulder pain and stiffness for at least 3 months.
* Restriction in shoulder flexion, abduction, internal and external rotation ROM less than 50% when compared to the other shoulder.

Exclusion Criteria:

* Shoulder or acromioclavicular joint osteoarthritis.
* Bone diseases.
* Infection.
* Severe osteoporosis.
* Tumors or metastasis.
* History of previous shoulder trauma or accidental injuries.
* Previous history of dislocation.
* Previous history of surgery on the specific shoulder.
* Any other shoulder problems.
iLook Out for Child Abuse: An Innovative Learning Module for Childcare Providers

This five-year study aims to improve childcare provider (CCP) reporting of suspected child abuse by means of an online learning module, iLook Out for Child Abuse. Using an interactive, video-based story-line (along with follow-up activities), iLookOut engages CCPs emotionally and intellectually to take the first step in addressing the epidemic of child abuse -which in the U.S. claims \>680,000 confirmed victims annually. The consequences of child abuse can be devastating and long-lasting. The purpose of this study is to establish an evidence-based intervention that can help those who care for young children recognize and report suspected child abuse before irreparable harm occurs.

This 5-year study will evaluate the efficacy of an innovative educational intervention, iLook Out for Child Abuse (iLookOut) for increasing rates of accurate child abuse reporting. Grounded in an Experiential Learning conceptual model, iLookOut is a multi-media, online intervention that engages learners emotionally and intellectually through an interactive, video-based story-line that provides education, challenges learners with decision-points, and gives critical feedback. iLookOut uses "gamification" strategies to promote experiential learning through simulation, problem-solving, and practice opportunities to apply new information and understanding. It also will include follow-up activities that promote retention and integration of new knowledge, as well as help CCPs to remain aware and engaged.

Prior studies have demonstrated that iLookOut significantly improves CCP knowledge and attitudes about reporting suspected child abuse, and is very well received by CCPs. To evaluate its impact on actual reporting behavior, the proposed research will randomize CCP sites in southern Maine (total = \~1,300) to receive iLookOut, Standard training, or Control (no intervention).

The primary goal is to increase the number of CCP reports for which either child abuse is confirmed or social services (e.g., therapeutic services, nutritional assistance) are recommended -as these are the kinds of reports that are likely to actually benefit a child.

The secondary goal is to decrease the proportion of reports that don't offer such benefit, and in particular to decrease costs to the state associated with intake and investigation of non-beneficial reports.

Eligibility Criteria:
Inclusion Criteria:

* Works or volunteers at a childcare facility in Maine (i.e., home-based childcare, childcare center, Head Start facility, nursery school, pre-school)
* 18 years of age or older

Exclusion Criteria:

* Does not work or volunteer at a childcare facility in Maine
* Under 18 years of age
High and Low Laser for Subacromial Impingement Syndrome

Shoulder pain is the third most common musculoskeletal problem after lumbar and neck diseases in clinical practice, and the most common cause of shoulder pain is subacromial impingement syndrome. The main goal of treatment is to reduce pain and to solve the mechanical problem that causes functional impairment. Low-level laser treatment is an increasingly used treatment modality in the treatment of subacromial impingement syndrome as in many musculoskeletal diseases, as it promotes cell proliferation and tissue regeneration by its anti-inflammatory and photobiostimulation properties. Also, High-intensity laser therapy is a treatment method that is gaining popularity in the recent years. These ultra-short impulses effect a deep action in the biological tissue (3-4 cm), with a homogeneous distribution of the light source in the irradiated soft tissue, but without excessive thermal enhancements. It reduces pain and edema with photomechanic effects in deep tissues. As far as the investigators know, there are no studies comparing these two treatment modalities in subacromial impingement syndrome yet. This study was planned to compare the efficacy of High-intensity laser therapy and low-intensity laser therapy in treatment of patients with subacromial impingement syndrome.


Eligibility Criteria:
Inclusion Criteria:

* shoulder pain for at least one month
* male and female patients with age range from 25-45 years old
* positive impingement test results
* stage I or II disease according to the Neer classification, confirmed by MRI
* visual analog scale score greater than 40 mm.

Exclusion Criteria:

patients will be excluded if they have:

* major trauma to the shoulder
* stage III subacromial impingement syndrome
* diabetes mellitus
* hypothyroidism
* calcific tendinitis
* adhesive capsulitis (forward flexion less than 160, horizontal abduction less than 160
* installation of cardiac pacemaker
* history of a physical therapy program for the same shoulder in the last 6 months.
A Study Evaluating the Clinical Outcome of a Modified d'Hoore Technique for Laparoscopic Ventral Mesh Rectopexy

The purpose of this observational study is to evaluate the clinical outcome of a modified d'Hoore technique for laparoscopic ventral mesh rectopexy in patients with primary rectal prolapse, rectocele and/or enterocele.The goal of the study will be achieved by reporting the peri- and postoperative complications ((serious) adverse events), recurrences and re-interventions. Pre-operative to postoperative changes in pain, functional outcome and quality of life will be evaluated as well.


Eligibility Criteria:
Inclusion Criteria:

* Female patients.
* Patient ≥ 18 years of age at study entry.
* Patient and investigator signed and dated the informed consent form prior to the index-procedure.
* Patient with primary rectal prolapse (grades I to V according to the Oxford scale), rectocele and/or enterocele.

Exclusion Criteria:

* Patient is unable / unwilling to provide informed consent.
* Patient with recurrent rectal prolapse, rectocele and/or enterocele.
* Patient is unable to comply with the study protocol or proposed follow-up visits.
* Patient has a contra-indication for laparoscopic ventral mesh rectopexy.
A Quality of Life Study in Patients Undergoing Percutaneous Biliary Drainage

The purpose of this study is to compare the participant's health-related quality of life before and after the biliary drainage procedure. The study will also help us learn whether having a drainage catheter or a stent placed during the procedure makes a difference in the participant's quality of life.


Eligibility Criteria:
Inclusion Criteria:

* Patients with known malignancy presenting for treatment of biliary obstruction
* Undergoing initial Interventional Radiology PBD procedure
* Fluent in English to enable instrument completion
* At least18 years of age
* Must be physically and mentally capable of completing instruments
* Must be able to comprehend and execute informed consent

Exclusion Criteria:

* Patients will be excluded if:

  * Indication for drainage is acute, symptomatic cholangitis requiring an emergent procedure
  * Previous PBD procedure
  * Presence of an indwelling biliary stent
* Medical or psychiatric condition that, in the judgment of the consenting professional, prevents appropriate comprehension and execution of either the informed consent or the study instruments
Study of Post-anesthesia Management in Patients Undergoing Neurosurgery

The postoperative complications of neurosurgery are various and complex, which brings heavy economic and social burden to families. Timely detection and early intervention can help reduce the incidence of adverse events and mortality. The main purpose of this study is to analyze the possible factors related to postoperative complications of Neurosurgery, so as to achieve the prospective prevention and treatment of postoperative complications of neurosurgery.


Eligibility Criteria:
Inclusion Criteria:

* Patients received neurosurgery in Beijing Tiantan hospital.

Exclusion Criteria:

* Preoperative severe cognitive dysfunction ；
* Refused to sign informed consent.
A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects

The purposes of this study are to:

1. Learn about the safety of CK-3773274 after a single dose and multiple doses in healthy subjects.
2. Learn how healthy subjects tolerate CK-3773274 after a single dose and multiple doses.
3. Find out how much CK-3773274 is in the blood after a single dose and multiple doses.
4. Determine the effect of doses of CK-3773274 on the pumping function of the heart.
5. Evaluate the effect of cytochrome genetic variants on how the body metabolizes CK-3773274.
6. Evaluate the effect of a meal on how much CK-3773274 is in the blood in healthy adult subjects.
7. Evaluate whether the amount of CK-3773274 in the blood is the similar for both the tablet and granules in capsule forms of the drug.


Eligibility Criteria:
Inclusion Criteria:

1. Males and females (of non-childbearing potential) between 18 and 55 years of age, inclusive
2. Body weight \> 55.0 kg and body mass index within 18.0 to 32.0 kg/m2, inclusive
3. Normal cardiac structure and function, or if abnormalities are present, they are deemed not clinically significant
4. Normal to high left ventricular ejection fraction.
5. Normal electrocardiogram (ECG) or, if abnormalities are present, they are deemed not clinically significant
6. Clinical laboratory findings within normal range
7. Negative hepatitis panel (including hepatitis B surface antigen and hepatitis C antibody), and negative human immunodeficiency virus antibody screens
8. Willing and able to refrain from strenuous exercise (eg, activity which could be expected to cause muscle soreness)
9. For Arms 5 and 6 only: Subject is a CYP2D6 poor metabolizer

Exclusion Criteria:

1. History of any significant illness or disorder
2. History of stomach or intestinal surgery or resection (appendectomy, hernia repair, and/or cholecystectomy will be allowed)
3. A clinically significant illness within 4 weeks of Check-in
4. Inability to swallow capsules or tablets
5. History of or current substance abuse (drug or alcohol), known drug or alcohol dependence within the last 2 years prior to Screening, or positive test for drugs of abuse during the screening period
6. Use of any tobacco-containing or nicotine-containing products within 3 months prior to Check-in
7. Participation in any other investigational study drug trial in which receipt of an investigational study drug occurred within 30 days prior to Check-in
8. Any blood donation within 60 days of dosing, plasma donation within 30 days of dosing, or receipt of blood products within 2 months prior to Check-in
Efficacy of Manual Therapy in the Treatment of Somatic Tinnitus

Somatic tinnitus is an unpleasant perception of sound that occurs in the absence of any external acoustic stimulus. Despite the correct diagnosis of somatic tinnitus, there is currently no specific treatment. The hypothesis of this study is that the application of manual therapy to the cervical region will help to treat tinnitus in patients. This study aims to investigate the effectiveness of manual therapy in the treatment of somatic tinnitus of cervicogenic origin.

Somatic tinnitus is an unpleasant perception of sound that occurs in the absence of any external acoustic stimulus. It results from complex interactions between the somatosensory and auditory systems, which involve the musculoskeletal system rather than the ear. The temporomandibular joint, craniocervical junction, cervical vertebrae and neck and shoulder muscles, in particular the sternocleidomastoid (SCM) muscle, upper trapezius and levator scapula, are anatomical regions that can cause somatic tinnitus.

Despite the correct diagnosis of somatic tinnitus, there is currently no specific treatment. The hypothesis of this study is that the application of manual therapy to the cervical region will help to treat tinnitus in patients. This study aims to investigate the effectiveness of manual therapy in the treatment of somatic tinnitus of cervicogenic origin.

Eligibility Criteria:
Inclusion Criteria:

Patients aged ≥ 18 and ≤ 65 years Patients fulfilling the clinical criteria4 defined for sevichogenic somatic tinnitus

1. Neck pain
2. Cervical joint range of motion limitation (especially rotation)
3. Modulation of tinnitus in relation to head and neck movements and posture
4. Tenderness in the cervico-occipital muscles Patients reporting cervical pain between \>2 and \<7 on a visual analogue scale (VAS) on most days of the last month Patients with stable medical and psychological status Patients willing to participate in the study

Exclusion Criteria:

Objective tinnitus Subjective tinnitus with hearing loss Meniere's disease History of vertigo Middle ear pathologies History of intracranial pathology History of whiplash injury History of cervical spinal surgery History of active infection, malignancy, inflammatory rheumatic disease or fibromyalgia Pregnancy Patients who have undergone any exercise or physiotherapy programme for the cervical region in the last 3 months
Reducing Pesticide Exposure in Minority Families

This is a community-based participatory research program focusing on pesticide contamination in migrant farmworker families.

This is a continuation of a community-based participatory research program focusing on pesticide contamination in migrant farmworker communities. Oregon Health Sciences University's Center for Research on Occupational and Environmental Toxicology and the Oregon Child Development Coalition propose to extend the participatory research model that has been developed to increase community capacity and to build knowledge on the nature and extent of childhood exposures to pesticides and resulting health effects. The project includes involvement from representatives of academic institutions, child and family educational, health, and social services, and the agricultural community. We propose to extend our program of research beyond the state of Oregon to accomplish the following specific aims:

1. Develop and validate a pathway model of organophosphate pesticide exposure for children residing near tree fruit orchards,
2. Conduct a longitudinal investigation of pesticide residue analysis, work practices, home characteristics and biological markers of exposure in migrant families residing in multiple homes and communities throughout a year,
3. Evaluate specific neurobehavioral outcomes in Latino children who speak Spanish and indigenous languages, living in homes with measured pesticide residues and in children living in homes with minimal measurable pesticide residues, and
4. Assess effectiveness of accepted methods of intervention including health education and environmental exposure reduction on changing behavior and reducing pesticide exposure in the migrant agricultural community.

The project also includes mechanisms to strengthen and expand the partnerships among migrant farmworker communities to increase the capacity of the community to address issues of environmental exposures and health. Training opportunities are provided for youth from the Latino farmworker community in environmental issues in affected communities. In addition to measuring the outcome of our research interventions in modifying exposures to pesticides and resulting health effects we have incorporated a comprehensive evaluation plan including measures to document increased research capacity in the community, leveraging by obtaining additional funding for further efforts, sustainability, culturally appropriate tools, policy or systems change, and impact on the field.

Eligibility Criteria:
Working in agriculture.
Efficacy and Safety of Sitravatinib Plus Tislelizumab or Placebo Plus Tislelizumab Versus Placebo as Adjuvant Treatment in Participants With Hepatocellular Carcinoma

The purpose of this study is to compare the efficacy and safety of sitravatinib plus tislelizumab or placebo plus tislelizumab versus placebo. The study will also compare the recurrence-free survival (RFS) in participants with hepatocellular carcinoma (HCC) who are at high risk of recurrence after surgical resection.


Eligibility Criteria:
Key Inclusion Criteria:

1. Participant with a first diagnosis of HCC must have undergone a curative-intent resection within 4 to 12 weeks before randomization and have a documented histological confirmation of HCC diagnosis and negative surgical margins (R0 resection) of the resected tumor
2. Participant must have tumor-free status as assessed by the investigator and have fully recovered from surgical resection before randomization
3. Participant must have no extrahepatic HCC
4. ECOG Performance Status ≤ 1
5. Participant who has undergone surgical resection and is defined as having a high risk of HCC recurrence

Key Exclusion Criteria:

1. Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC histology
2. Evidence of residual, recurrent, or metastatic disease of HCC before randomization
3. Major macrovascular (gross vascular) invasion of the portal vein (Vp3 or Vp4) or any grade of macrovascular invasion in the hepatic vein or inferior vena cava
4. Untreated chronic hepatitis B (HBV) or chronic HBV carriers with HBV DNA ≥ 2000 IU/mL at Screening
5. Untreated or incompletely treated esophageal or gastric varices with bleeding or high risk of bleeding

Note: Other protocol defined Inclusion/Exclusion criteria may apply
Lessons on Urethral Lidocaine in Urodynamics

This trial will assess whether use of intraurethral 2% lidocaine jelly meaningfully impacts sensation during filling (i.e., a change of more than 25% of first sensation, first desire to void, strong desire to void, or maximum cystometric capacity) and determine whether the use of intraurethral 2% lidocaine jelly meaningfully impacts pain/discomfort, filling metrics, and voiding metrics.

This trial is a randomized, double blind, controlled trial for patients undergoing complex cystometric evaluation. Patients will undergo routine complex cystometric evaluation for acquisition of baseline data using a small amount of intraurethral aqueous jelly for catheter lubrication. Then, they will be randomized to instillation of either placebo (additional intraurethral aqueous jelly, 5ml) or intraurethral 2% lidocaine jelly. Participants then undergo complex cystometry a second time. Normal variations in studies with placebo will be compared to variations within the 2% lidocaine jelly group to determine if cystometric parameters are altered in any clinically important ways. Patient discomfort will also be evaluated by both the patient and the urodynamics advanced practice nurse.

Eligibility Criteria:
Inclusion Criteria:

* Female patients
* \>18 years of age
* Already scheduled (or being scheduled) for UDS to assess urinary incontinence
* Able to speak and read in English

Exclusion Criteria:

* Diagnosis of pelvic pain, interstitial cystitis, or bladder pain syndrome
* Known neurogenic disease impacting voiding/ continence (e.g., Parkinson disease, multiple sclerosis, myasthenia gravis, recent stroke)
* Active UTI
* Pelvic organ prolapse that is unable to be easily reduced
* Pregnancy or breastfeeding
* Allergy or hypersensitivity to lidocaine or local anesthetics
Erythropoietin Effect on Ischemic_ Reperfusion Injury in Coronary Artery Bypass Graft Surgery

The aim of this trail is to assess the safety and therapeutic effects of single EPO intervention in different times during coronary surgery in changes of inflammatory response.

In addition to well-known effect of Erythropoietin (EPO) on erythropoiesis in hypoxic conditions, some lines of evidence suggest its protective effects against reperfusion injury in several tissues by its specific receptor.

Preclinical studies have indicated a broad variety of cardioprotective actions for EPO. It improves cardiac function and exercise capacity in congestive heart failure, angiogenesis, limit myocardial inflammatory response, cardiac remodeling, infarct size and apoptosis extension induced by reperfusion injury. Activation of EPO receptor in endothelial and cardiac cells is suggested to attenuate proinflammatory cytokines production and inflammatory cells infiltration, and increasing nitric oxide production through possible mechanisms.

Reperfusion injury is unavoidable event during cardiac surgery using cardiopulmonary bypass.It is associated with inflammation, cell injury and attenuate contractility property.

Although it is an area of concern and many clinical studies have been designed by different interventions, it remains a major challenge. EPO intervention during heart reperfusion (surgery/ percutaneous angioplasty) as a new promise of cardioprotection strategy is the main design of several studies with conflicting results .

Eligibility Criteria:
Inclusion Criteria:

* Revascularization requirement according to angiographic evidence
* Elective coronary artery bypass graft surgery
* First time coronary artery bypass graft surgery
* On-pump coronary artery bypass graft surgery

Exclusion Criteria:

* History of myocardial infarction in the past 3 months
* Previous myocardial trauma or major surgery in the past 3 months
* Cr\>2mg/dl
* Receiving streptokinase or previous reperfusion treatments
* Erythropoietin intake in the recent 6 months
* Known thromboembolic disorder and malignant disease
* Uncontrolled hypertension
* Polycythemia
* Previous valvular surgery
Different Stylet Angles for Orotracheal Intubation Using Glidescope® Video Laryngoscope in Children

The purpose of this study is to evaluate the feasibility of endotracheal intubation via glidescope videolaryngoscope (GVL) using different curve of stylet in 120 children aged between 1 and 5 year old.

Pediatric patients aged 1-5 year old are randomly assigned to one of two groups; standard curve (S) and tip-manipulated curve (T) groups. After routine anesthetic induction, endotracheal intubation is performed with GVL. Size of GVL blade is selected according to weight; GVL 0: \<1.5kg, GVL 1:1.5-3.6kg, GVL 2: 1.8-10kg, GVL 2.5: 10-28kg). Before intubation, stylet curve is differently manipulated according to group. The style is curved in accordance with the curve of GVL blade in S group, whereas the distal tip of style is additionally bended to the left (15-20 degree) in T group.

Time from visualization of glottis with GVL to approaching of endotracheal tube to glottis, and time to completion of intubation are measured. In addition, the easiness of intubation is assessed using Visual Analogue Scale (0: extremely easy, 10: extremely difficult) and will be compared in both groups.

Eligibility Criteria:
Inclusion Criteria:

1. children aged between 1 and 5 years who are scheduled for elective surgery
2. American Society of Anesthesiologist physical status I, II

Exclusion Criteria:

1. History of asthma
2. Active upper respiratory infection
3. Significant cardiopulmonary disease