cyrilzakka/clinical-trials huggingface dataset:
Comparing Use of a Prehospital Ultrasound System and Standard Prehospital Care in Thoracoabdominal Trauma

The NanoMaxx Ultrasound System (SonoSite) in connection with the RP-Xpress (InTouch Technologies) provides a means of transmitting ultrasound images, video, and audio to a remote location in real-time. It has been envisioned that this system be used to diagnose trauma patients with suspected pleural effusion, hemothorax, pneumothorax, or abdominal blockage during prehospital care; under the guidance of in-hospital physicians, paramedics would perform an Focused Assessment with Sonography for Trauma (FAST) examination while trauma patients are transported to hospital via ambulance. The investigators hypothesize that in-hospital physicians interpreting ultrasound images obtained by paramedics during trauma patients' transportation to hospital will reduce time to diagnosis; thus, preparations by emergency physicians, surgeons, and operating room teams to receive critically injured patients may begin earlier, reducing time to intervention during a critical period in patient care. Data will also be collected regarding quality of images obtained in-ambulance and the interaction between paramedics and physicians using the remote-presence system.


Eligibility Criteria:
Inclusion Criteria for FAST cohort:

* Patient is 18 years of age or older
* Patient presenting with blunt or penetrating trauma to the thorax or abdomen
* Patient transported by MD Ambulance to Royal University Hospital
* Patient being transported by a paramedic who has received training in the above ultrasound system and who has with them a NanoMaxx Ultrasound System (SonoSite) to be used in connection with the RP-Xpress (InTouch Technologies)
* Patient will take longer than 10 minutes to transport to hospital
* Patient's care will not be compromised in completing a FAST exam - opinion of paramedic
* Patient's care will not be compromised in completing a FAST exam - opinion of ER physician

Inclusion Criteria for Controls:

* Patient is 18 years of age or older
* Patient presenting with blunt or penetrating trauma to the thorax or abdomen
* Patient transported by MD Ambulance to Royal University Hospital
* Patient will take longer than 10 minutes to transport to hospital

Exclusion Criteria:

* Patients under the age of 18
* Patients whose care would be compromised if other procedures of higher priority (as determined by paramedics and/or remotely-present physicians) were not be able to be executed due to time involved in completing a FAST exam
* Patients who are not being transported to Royal University Hospital
* Patients whose expected transport time from scene to hospital is less than 10 minutes
Effects of Tele Speech Therapy on the Treatment of Stammering in Adults Who Stutter

The aim of the study is to determine the effectiveness of telespeech therapy on the treatment of stammering.


Eligibility Criteria:
Inclusion Criteria:

* Both Genders
* Adults With stuttering 15 to 40 years according to WHO criteria

Exclusion Criteria:

- Stammering with any comorbid are excluded eg. Visual and Hearing Impairment
Effect of a Female Strength & Conditioning Specialist on High School Girls' Health

The majority of today's youth do not engage in enough physical activity (PA) to maintain good health. Low PA levels are associated with poor health (e.g. diabetes, high blood pressure) and early mortality. Girls are less likely than boys to be active, and their rates of participation drop off more steeply during adolescence. Girls report many barriers to exercise, including transportation issues and feeling self-conscious about their appearance and abilities. School-based PA programs that try to improve health, mainly through aerobic exercise and education, have had a small effect to date. However, the few programs that included resistance training as the focus showed strong improvements in health related measures. In this project, we will examine the effect of a female strength and conditioning specialist on decreasing barriers and increasing the overall health of high school girls, with the delivery of in-school, girls-only resistance training programs. We will see if physical and mental health changes with the training, and how the presence of the S \& C specialist affects the girls' social interactions within the school. The results will help individuals in the education sector plan programs and services to improve overall youth and school health.


Eligibility Criteria:
Inclusion Criteria:

* Grades 7 to 12 at Grant Park High School
* do not participate on organized sports teams
* self-report as not meeting the recommended amount of 60 min of Moderate-Vigorous Physical Activity per day

Exclusion Criteria:

* engaged in regular resistance training activities within the previous 6 months
* health condition or injury that would put them at risk during testing/training
A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne

The purpose of this study is to compare the tolerability of topical combination therapies in the treatment of facial acne.

The purpose of this study is to compare the tolerability of topical combination therapies in the treatment of facial acne.

Eligibility Criteria:
Inclusion Criteria:

* Male or female subjects at least 21 years of age, in good general health with documented diagnosis of acne vulgaris.
* Female subjects of childbearing potential must have a negative pregnancy test. Sexually active women of childbearing potential participating in the study must use a medically acceptable form of contraception Abstinence is considered an acceptable method of contraception.
* Inflammatory (papules and pustules) and non-inflammatory (open and closed comedones) facial lesions.
* The ability and willingness to follow all study procedures, attend all scheduled visits, and successfully complete the study
* Capable of understanding and willing to provide signed and dated written voluntary informed consent (and any local or national authorization requirements) before any protocol specific procedures are performed

Exclusion Criteria:

* Female subjects who are pregnant, trying to become pregnant or breastfeeding.
* Subjects who have any clinically relevant finding at their baseline physical other than acne vulgaris.
* History or presence of regional enteritis or inflammatory bowel disease (eg, ulcerative colitis, pseudomembranous colitis, chronic diarrhea, or a history of antibiotic-associated colitis) or similar symptoms.
* Use of topical antibiotics or anti-acne medications on the face and systemic antibiotics within the past 2 and 4 weeks, respectively.
* Use of topical corticosteroids on the face or systemic corticosteroids within the past 4 weeks. Use of inhaled, intra-articular or intra-lesional (other than for facial acne lesions) steroids is acceptable.
* Use of systemic retinoids within the past 6 months.
* Facial procedures performed by an esthetician, beautician, physician, nurse, or other practitioner, within the past 4 weeks or during the conduct of the study.
* Known hypersensitivity or previous allergic reaction to any of the active components, lincomycin, adapalene, clindamycin, benzoyl peroxide or excipients of the study product.
Mechanical Thrombectomy for Acute Lower Limb Deep Vein Thrombosis in Tumor Patients

This study will conduct a prospective single blind controlled study on the clinical efficacy and safety indicators of 50 cancer patients with acute lower limb deep vein thrombosis (DVT). The patients were randomly divided into an experimental group (improved mechanical thrombectomy (PMT) group) and a control group (traditional simple anticoagulation group) using the "envelope method", with 25 cases each. After the end of treatment, clinical prognosis evaluations were conducted on the patient's vital signs, symptoms and signs, lower limb Doppler ultrasound examination, patient PTS score (Villalta score), quality of life score (QOL), etc. at 3, 6, and 12 months. Adverse events, the presence or absence of thrombus recurrence, and re surgical intervention were recorded. This study is expected to propose a new strategy for the treatment of acute DVT in cancer patients, thereby improving the overall level of VTE prevention and treatment.


Eligibility Criteria:
Inclusion Criteria:

* 1) Between the ages of 18 and 75; 2) Suffering from acute lower limb deep vein thrombosis (DVT) with a duration of less than 14 days from onset; 3) Thrombosis involving the iliac vein, femoral vein, or popliteal vein; 4) The patient has been diagnosed with tumors, including benign or malignant tumors, including surgical or conservative treatment; 5) Sign an informed consent form.

Exclusion Criteria:

* 1) Patients with a history of deep vein thrombosis of the same lower limb in the past; 2) Patients with plasma Cr levels greater than 180umol/L; 3) Patients with contraindications to thrombolytic drugs; 4) Patients with concomitant inferior vena cava thrombosis or simple calf intermuscular vein thrombosis; 5) Patients who are known to be allergic to heparin, low molecular weight heparin, contrast agents, etc; 6) Patients who have participated in clinical trials of drugs or other medical devices that interfere with this clinical trial within the past 3 months; 7) Pregnant and lactating women; 8) Patients with a life expectancy of less than 6 months, or those with other diseases that may cause difficulty in testing or significantly shorten the patient's life expectancy (\<1 year), including severe liver disease, cardiac insufficiency, etc; 9) Patients with autoimmune thrombotic disease; 10) Patients who are unable or unwilling to participate in this trial.
ENVISION: A Study to Evaluate the Efficacy and Safety of Givosiran (ALN-AS1) in Patients With Acute Hepatic Porphyrias (AHP)

The purpose of this study is to evaluate the effect of subcutaneous givosiran (ALN-AS1), compared to placebo, on the rate of porphyria attacks in patients with Acute Hepatic Porphyrias (AHP).


Eligibility Criteria:
Inclusion Criteria:

* ≥ 12 years of age
* Diagnosed with Acute Hepatic Porphyria (Acute Intermittent Porphyria, Hereditary Corproporhyria, Variegate Porphyria, aminolevulinic acid (ALA) dehydratase deficient porphyria)
* Elevated urinary or plasma porphobilinogen (PBG) or ALA values within the past year,
* Have active disease, with at least 2 documented porphyria attacks within the last 6 months
* Willing to discontinue or not initiate the use of prophylactic hemin throughout the study.
* Women of child bearing potential must have a negative serum pregnancy test, not be nursing, and use acceptable contraception

Exclusion Criteria:

* Clinically significant abnormal laboratory results
* Anticipated liver transplantation
* History of multiple drug allergies or intolerance to subcutaneous injections
* Active HIV, hepatitis C virus, or hepatitis B virus infection(s)
* History of recurrent pancreatitis
The Effect of Modular Education on Individuals Diagnosed With Hypertension

Aim:This study focused on patients with hypertension to investigate the effect of a nurse-led counseling program on their self-efficacy and disease adherence.

This study adopted a randomized-controlled and intervention research method. Data were collected between September 2022 and February 2023 at the internal medicine outpatient clinic of Adana City Hospital.

Participants were recruited using random sampling. Simple randomization was used to allocate both groups equally and randomly (https://www.randomizer.org/). The researcher first created a randomization list. Then, she assigned participants to the intervention and control groups according to the list. Blinding was impossible because the research involved a training program. A power analysis (G\*Power 3.1.9.4) was performed based on the effect size (d = 0.93) reported by Zhang et al. (Zhang et al., 2021). The results showed that a sample of 62 would be large enough to detect significant between-group differences (power 95%, margin of error 5%, and confidence interval 95%). The results showed that a sample of 42 was large enough to detect significant differences \[alpha= 0.05 and power (1- beta) 0.80\]. However, each group comprised 23 participants to avoid missing data and the execute parametric tests.Data were collected using a personal information form, the Hypertension Self-Efficacy Scale (HSES), the Modified Morisky Scale (MMS), and the Adaptation to Chronic Illness Scale (ACIS). The inclusion criteria were (1) having had hypertension at least for six months, (2) being an adult (over 18), (3) not having received training on hypertension before, (4) having no communication problems, (5) not being pregnant, and (6) volunteering.

Eligibility Criteria:
Inclusion Criteria:

* Having had hypertension at least for six months
* Being an adult (over 18),
* Not having received training on hypertension before,
* Having no communication problems,
* Not being pregnant,
* Volunteering

Exclusion Criteria:

* Hypertension diagnosis duration is less than 6 months
* Having verbal communication problems
* Not volunteering to participate in the study
National Snapshot Study Adhesive Small Bowel Obstruction (ASBO)

Over 63-90% of patients develop peritoneal adhesions after abdominal or pelvic surgery. Which makes it the most common complication after abdominal or pelvic surgery. Adhesions comprise a lifelong risk of adhesion related complications.The most frequent emergency complication of adhesion is an episode of adhesive small bowel obstruction (ASBO). Over 1 in 5 patients experiences at least 1 episode of ASBO in the 10 years following initial abdominal surgery. Despite the high incidence of ASBO, diagnosis and treatment of an episode of ASBO varies greatly between hospitals and even between doctors. Until now, optimal treatment patterns are unknown. The aim of this study is mapping of care for patients with a suspected episode of ASBO. With the collected data new hypothesis will be generated for the ideal diagnostic and therapeutic workflow for patients with a suspicion of an episode of ASBO.


Eligibility Criteria:
Inclusion Criteria:

* Suspicion ASBO
* Age 18 years or older

Exclusion Criteria:

* Clear other cause of small bowel obstruction (e.g. tumor, hernia)
Pharmacy-based PrEP for Young Women Who Sell Sex in Zimbabwe

Pharmacy-based PrEP for Young Women who Sell Sex in Zimbabwe is a cluster-randomized control trial and pilot study co-led by Dr. Euphemia Sibanda, Reader (Associate Professor) of Global Health and Epidemiology at Liverpool School of Tropical Medicine, UK and Research Director at the Centre for Sexual Health and HIV Research (CeSHHAR Zimbabwe) and Dr. Sandra McCoy, Professor of Epidemiology and Biostatistics at the University of California, Berkeley. The goal of the proposed study is to optimize, refine and pilot a pharmacy-based PrEP intervention for female sex workers (FSW) in Zimbabwe. Despite efforts to reach the most impacted and vulnerable populations with PrEP, retention rates, particularly among FSW in Africa, are very low. Relatively high levels of uptake indicate that FSW are interested in PrEP and ready to initiate it, but in most cases fewer than 50% of those who initiate return for medication refills by month 4. Pharmacy-based PrEP has the potential to address known barriers to PrEP retention among FSW such as stigma and access, and coupled with a small escalating incentive in the form of a gift card incentive, could also boost motivation for effective use of PrEP.


Eligibility Criteria:
Inclusion Criteria:

* 1) Exchanged sexual intercourse for money or gifts in past 6 months
* 2) Age 16 or older
* 3) HIV negative (via rapid test per national guidelines) at enrollment and no signs/symptoms of acute HIV infection
Feasibility Clinical Study of NLA Tool

The study is to evaluate the feasibility of the NLA tool, a combined assessment of nutritional and physical functional status, to provide personalized advice for the independence and mobility of elderly.


Eligibility Criteria:
Inclusion Criteria:

1. aged between 65 and 90 years,
2. able to walk with or without walking aid,
3. having obtained the subject's written informed consent
4. free of cognitive impairment,

Exclusion Criteria:

1. restricted by a doctor to exercise.
2. unable to carry out performance tests and questionnaires correctly,
3. lower or upper extremity surgery or fracture in the last 3 months
4. having history of neurological disease (e.g., Parkinson disease, stroke) with residual impairment
Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study

The best management of the acute cholecystitis is to do laparoscopic cholecystectomy. The hypothesis is that to do it as an early intervention after patient admission is better than delayed cholecystectomy regarding the hospital stay, interval for antibiotic, the easiness of the operative maneuver reflected by operative time, conversion and intraoperative complications.

Doing laparoscopic cholecystectomy for patients with acute cholecystitis as an early intervention after patient admission ( first group) or to do it after a while of treatment and conservation as a delayed cholecystectomy (second group) points of study include the hospital stay, interval for antibiotic, the easiness of the operative maneuver reflected by operative time, conversion and intraoperative complications.

Eligibility Criteria:
Inclusion Criteria:

* Proved acute cholecystitis clinical, radiologic

Exclusion Criteria:

* Evidence of peritonitis
* ASA III or IV
* Previous upper abdominal surgery
* Pregnancy
Culinary Medicine vs. Nutrition Education in Diabetes

This pragmatic trial compares the effectiveness of virtual culinary medicine classes vs. standard of care medical nutrition visits to improve glycemic control in patients with uncontrolled type 2 diabetes . Culinary medicine teaches healthy eating principles through a combination of experiential cooking classes and focused didactic sessions. The primary study outcome is glycemic improvement (A1c). Qualitative evaluation will assess participant experience, impact, and durability of behavior changes related to nutrition. A short term cost analysis will be conducted to inform program costs and cost effectiveness.

A total of 130 participants with uncontrolled type 2 diabetes will be recruited from a safety-net health system that provides comprehensive care for the uninsured and underinsured residents of Dallas County, Texas. Eligible participants will be actively engaged in primary care and recruited from clinical practice. Participants will be randomized to two arms: Culinary Medicine and standard of care medical nutrition therapy (MNT). Certified culinary medicine instructors will deliver a series of 6 monthly Culinary Medicine classes virtually with participants cooking in their own homes. A series of 6 standard of care medical nutrition sessions will be delivered by the health system using a combination of individual and group sessions both in person and virtually. All participants will be enrolled in a 12 month food assistance program in partnership with community based partners to provide access to healthy foods. Classes will be delivered over 6 months, and participants will be followed for an additional 6 months to assess the durability of glycemic response and behavior changes. A cost analysis will examine the system cost to deliver the intervention and the short term cost effectiveness examining the cost per participant achieving a clinically meaningful reduction in A1c.

Eligibility Criteria:
Inclusion Criteria:

* No nutrition visit in the past 12 months.
* Hemoglobin A1C ≥ 7.5% within the past six months.
* Diagnosed with established Type 2 Diabetes \> 12 months
* Receiving primary care at Hatcher Station Health Center and an assigned primary care provider within the past 18 months.
* Completion of at least 2 of the 4 Health Living with Diabetes (HLWD) virtual and/or in-person sessions.

Exclusion Criteria:

* Patients who cannot hear virtual and/or in-person instruction
* Patients who cannot read or speak English or Spanish
* Patients who are unable to understand study information
* Patients younger than 18 years of age
* Patients who are unable to communicate with voice (for participation in phone surveys, focus groups and semi-structured interviews)
* Patients without access to a smart phone or other device with internet and/or data capability to participate in virtual classes
* We will exclude patients with chronic kidney disease (CKD) stage 4 or 5 (eGFR \< 30 or on dialysis) because their renal function may require additional nutritional counseling and dietary modifications beyond the scope of the proposed culinary medicine and nutrition sessions delivered in this study.
Theta Burst Stimulation for Alcohol Use Disorder

The study will examine the effects of two continuous theta burst stimulation (cTBS) sessions (given in a single day) on resting state functional MRI (fMRI), alcohol cue related attentional bias and alcohol craving in patients with alcohol use disorder (AUD).

Although pharmacotherapy and behavioral treatments have been approved for AUD, their effects sizes are modest. Noninvasive neuromodulation like Transcranial magnetic stimulation (TMS) can offer an alternative treatment option for AUD. TMS is a method of noninvasive neuromodulation that utilizes a magnetic field to focal electrical current in the brain. When these electrical currents are focused on specific brain regions, pertinent to the neurobiology of AUD it leads to modulation of behavior and plausibly decrease in alcohol craving and use. Previous TMS studies have used heterogenous parameters, including frequencies ranging from 1 Hz to 20 Hz. Regions targeted by these studies encompassed ventromedial prefrontal cortex, left dorsolateral prefrontal cortex (left dlPFC) and right dorsolateral prefrontal cortex. Two studies used a TMS paradigm with greater efficiency than other routine TMS paradigms, called continuous theta burst stimulation. These studies delivered 3600 pulses of cTBS to the left frontal pole/ventromedial prefrontal cortex and showed significant reduction in alcohol cue reactivity and corroborative changes in both resting state and task based functional connectivity. Of these two studies, one was notable in comparing active cTBS (3600 pulses per session, one session every day for ten days over two weeks) versus sham cTBS. A deep TMS (dTMS) study that compared dTMS (15 sessions, five sessions every week for three weeks) to sham dTMS using an H7 coil (targeting medial prefrontal and anterior cingulate cortices). This study showed decreased craving after treatment and percentage of heavy drinking days in the active versus sham control group. Active dTMS was associated with decreased resting-state functional connectivity of the dorsal anterior cingulate cortex with the caudate nucleus and decreased connectivity of the medial prefrontal cortex to the subgenual anterior cingulate cortex. No study has done multiple sessions of cTBS in a single day. In addition, no study has previously delivered cTBS to the left dlPFC, to modulate alcohol craving and alcohol cue based attentional bias.

Eligibility Criteria:
Inclusion criteria.

* Patients seen at a clinic within the University of Kentucky Healthcare
* 21-60 years of age
* male or female gender
* Able to read, understand and communicate in English
* willing to adhere to the general rules of the UK Healthcare
* Must fulfill criteria for moderate alcohol use disorder.

Exclusion criteria

* Positive pregnancy test for females
* traumatic brain injury, history of seizure disorder, history of or current diagnosis of schizophrenia
* intracranial metal shrapnel
* previous adverse effect with TMS
* sub-threshold consistency while performing behavioral tasks
* failure to show baseline attentional bias to alcohol versus neutral cues.