cyrilzakka/clinical-trials huggingface dataset:
Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis

Purpose: Intracranial atherosclerosis is a common condition in Korean population consisting over 25% of ischemic stroke etiology. American Stroke Association and Korean Stroke Society recommend antiplatelet and statin for the treatment of intracranial atherosclerosis. Besides lowering blood cholesterol levels statin also stabilize atherosclerotic plaque and eventually lower the risk of ischemic stroke. However, little evidence resides on the effect of statin treatment on intracranial atherosclerosis. Recent advance in high-tesla magnetic resonance imaging enables direct imaging of intracranial atherosclerotic plaque and further assessment of treatment efficacy of statin in stabilization of intracranial atherosclerotic plaque became possible.


Eligibility Criteria:
Inclusion Criteria:

* Acute ischemic stroke patients within 7 days of symptom onset
* Symptomatic intracranial artery stenosis (above 30%) at proximal portion of middle cerebral artery (MCA), basilar artery, or intracranial portion of intracranial artery (ICA).
* Not receiving statins (HMA-coA reductase)
* Willing and able to comply with scheduled visits, lifestyle guidelines, treatment plan, laboratory tests, and other study procedures.

Exclusion Criteria:

* Extracranial artery (carotid artery bifurcation, proximal vertebral artery) stenosis above 50%
* Stroke attributable to cardioembolic origin (atrial fibrillation, valvular heart disease, aortic arch atherosclerosis)
* Severe hepatic or renal dysfunction
* Pregnant females as determined by positive urine hCG test or lactating females
* Subjects considered unwilling or unable to comply with the imaging procedures and study visit schedule
Assessment of Visual Performance With Virtual Reality After Cataract Surgery

The proposed randomized clinical trial aims to compare visual performance, measured using VR simulations, in cataract patients implanted either with bilateral trifocal IOL or bilateral monofocal IOL with monovision. The hypothesis is that patients implanted with trifocal IOL would exhibit superior visual performance, in both daytime and nighttime conditions, compared to those with a monofocal IOL with monovision.

Cataract surgery provides an opportunity to restore the quality of life by improving vision. While monofocal intraocular lenses (IOLs) implantation with monovision has been a common approach for cataract surgery, it may result in limited clarity at the intermediate distance and reduced depth perception. The advent of multifocal IOLs has expanded the possibilities, potentially offering increased visual performance in different ranges of vision. However, the benefits of multifocal IOLs in everyday activities are not fully understood due to the lack of task-based investigations.

To address this gap, a virtual reality-based approach is proposed to simulate daily activities and assess visual performance. This innovative method can provide insights into how multifocal IOLs enhance activities requiring good binocular vision at varying distances, a capability monofocal IOLs may lack. A randomized clinical trial is suggested to compare the TECNIS Synergy multi-focal IOL with the TECNIS monofocal IOL in monovision. Unlike its bifocal predecessors, the TECNIS Synergy IOL is trifocal, providing clear vision at near, intermediate, and far distances. The hypothesis is that patients implanted with the TECNIS Synergy IOL will demonstrate superior visual performance in simulated day and night conditions compared to those implanted with monofocal IOLs and monovision.

Eligibility Criteria:
Inclusion Criteria:

* Bilateral cataract
* Regular corneal astigmatism
* Corneal endothelium cell count \>2000 cells/mm2
* Clear intraocular media other than cataract

Exclusion Criteria:

* Concomitant ocular diseases
* Irregular corneal aberration
* Capsular instability
* Systemic disease that may affect vision
* History of other intraocular surgery
Correlation of Antibody Response to COVID-19 Vaccination in Pregnant Woman and Transplacental Passage Into Cord Blood.

The goal of this study is to study the correlation of maternal and cord blood level of Anti SAR-CoV.

The goal of this study is to study the correlation of maternal and cord blood level of Anti SAR-CoV. Sample size is 40 Thai patients at labor room Vachira Phuket Hospital in October - November 2023, who have at least one COVID-19 vaccination before or when pregnant. The Secondary outcome is to study time effect after COVID-19 vaccination and effect of vaccine type on Antibody level.

Eligibility Criteria:
Inclusion Criteria:

* Thai term pregnant women
* 18-45 year old
* At least 1 covid vaccination received
* admission at Vachira Phuket Hospital Labor Room

Exclusion Criteria:

* Do not want to participate
* Unstable or Emergency condition
Study to Analyse the Use of a Digital Platform for the Preparation and Follow-up of Patients With Scheduled Outpatients Colonoscopy

The goal of this clinical trial investigation with device is to to analyze the use of the Caaring® digital platform for the preparation and follow-up of scheduled colonoscopy.

Colonoscopy is a difficult procedure, and it is estimated that bowel preparation is inadequate in about 25% of patients. The main question it aims to answer is if the use of a digital platform (Caaring®) could be an effective tool for reducing the percentage of inadequate bowel preparations in patients with a scheduled colonoscopy. To this end, the application will provide precise instructions to patients.

A prospective, single-center, observational study with software device: The recruitment phase is expected to last two months. Patients will be followed for one month after the colonoscopy and 14 days prior to it.

Additionally, measuring patient experience and monitoring adverse effects after a colonoscopy are crucial to improving the safety of colonoscopies and the quality of healthcare, promoting higher quality colonoscopy services.

For that to happen, participants must have sufficient technological skills to use a smartphone.

A prospective, single-center, observational study with software device. The protocol and informed consent documents have been reviewed and approved by the hospital human subjects reviewboard and the study will be performed in accordance with the Declaration of Helsinki.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 or older.
* Signed informed consent.
* Patients scheduled for outpatient colonoscopy.
* Patients able to complete the study questionnaires.
* Patients who regularly use a smartphone

Exclusion Criteria:

* Patients enrolled in the population-based colorectal cancer screening program with a positive fecal occult blood test.
* Minors or elderly patients (over 80 years of age).
* Patients with prior colorectal surgery.
* Patients who, in the opinion of the researcher, will not be able to commit to follow-up or lack adequate technological skills.
* Inability to provide adequate informed consent.
Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial

Previous clinical studies have confirmed that revascularization or recanalization rate after intravenous thrombolysis is closely related to the formation of thrombus, which also results in poor neurological function after thrombolysis. Platelet activating factor (PAF) strong platelet aggregation may be involved in thrombosis. Formation process. The main components of Ginkgolide injection (Ginkgo) are ginkgolide, ginkgolides A, ginkgolides B and ginkgolides C. Ginkgo biloba lactone can antagonize PAF and has strong anti-platelet aggregation. . Therefore, it can be speculated that ginkgolides injection combined with alteplase intravenous thrombolysis may improve the recanalization rate after thrombolysis and reduce the reocclusion rate.

In addition, clinical studies have also found that ginkgolide injection has a good auxiliary effect on hypertensive intracerebral hemorrhage, which can regulate inflammatory factors such as IL-6, TNF-α and high-sensitivity C-reactive protein (CRP) in patients. Recovery of neurological function in patients. It is well known that TNF-α, IL-β, IL-1, IL-6, IFN-γ, etc. are all inflammatory factors associated with reperfusion injury. Therefore, we speculate that ginkgolides injection may also regulate inflammatory factors associated with reperfusion injury, such as IL-6, TNF-α, thereby reducing reperfusion injury, thereby improving patient prognosis.

The aim of this study was to determine the clinical efficacy of ginkgolides injection combined with alteplase in the treatment of acute ischemic stroke, and to improve the prognosis of patients with thrombolysis.


Eligibility Criteria:
Inclusion Criteria:

1. Age over 18 years old, clinically diagnosed as acute ischemic stroke;
2. in accordance with the indications for intravenous thrombolysis;
3. The patient or family member signs an informed consent form.

Exclusion Criteria:

1. Patients with transient ischemic attack;
2. Imaging examination of patients with cerebral hemorrhage
3. patients with cerebral arteritis
4. ALT, AST ≥ 3 times the upper limit of normal value, Cr ≥ 1.5 times the upper limit of normal value
5. There is a tendency to bleed, and severe bleeding has occurred within 3 months
6. Patients with ginkgo drugs, alcohol, glycerol allergies or allergies
7. Patients with pregnancy plans, pregnancy and breastfeeding
8. Patients who participated in other drug clinical studies in the past month
9. Patients considered by the investigator to be unfit to participate in the clinical study (eg, mental, abnormal, etc.)
Effect of Nepafenac Eye Drops on Intraocular Pressure in Normal Eyes

The Nevanac product information insert says that it can cause increase in eye pressure in 5-10% of patients. There is very little published literature on the effect of topical Nepafenac eye drops on eye pressure in normal people. The purpose of our study is to report this effect with a working hypothesis that there is no increase in eye pressure following use of Nepafenac eye drops.


Eligibility Criteria:
Inclusion Criteria:

* Best corrected visual acuity better than 20/80 in both eyes
* Intraocular pressure ≤21 mmHg in both eyes
* Open angles on 4 mirror gonioscopy without indentation
* Normal optic disc on stereoscopic examination and photographs

Exclusion Criteria:

* Change in the systemic medication profile during the course of the study
* Allergy to nepafenac molecule
* Corneal thinning/corneal infections
* Any intraocular surgery in past 3 months
* Pregnancy or those planning to conceive
* Breast feeding patients
* Unwillingness to participate in the trial
* Concomitant use of any other ocular drug (except artificial tears)
Cervical Activation During Elastic and Manual Resistance

Cervical pain is a condition that affects 14.6% of all adults annually. Of this annual prevalence, 37.3% experience persistent neck pain with periodic recurring episodes. The purpose of this study is to compare muscle activation patterns of the cervical musculature during exercises with elastic versus manual resistance in a neck pain and asymptomatic populations. Methods: A convenience sample of 15 healthy, physically active participants and 15 current patients diagnosed with non-radicular cervical pain will be recruited. Exclusionary criteria will include: current cervical or upper extremity injury (healthy group), history of neck surgery, corticosteroid treatment within the last two weeks, and radicular signs or symptoms. Surface electromyography will be used to quantify the activity level of the bilateral SCM, AS, Cervical Paraspinal (CP), and the Upper Trapezius (UT) muscles while performing a series of 6 exercises with elastic resistance using Thera-Band® Resistance Bands and manual resistance. The area will be prepped and surface electrodes placed on the corresponding muscles. The movement will be standardized by using the peak activation (PA) of each muscle during full flexion-extension movement to create a percentage of peak activation (%PA). The testing battery will consist of 6 exercises with elastic resistance and manual resistance, totaling 12 different trials. Each trial will involve 5 repetitions, each held for 5 seconds. The exercises will include cervical: extension, flexion, left rotation, right rotation, left side bending, and right side bending. The men will use the green and women will use the red Thera-Band® Resistance Band. The order of exercises will be randomized in to two parts to minimize the effect of fatigue. First, cervical flexion and extension with manual and elastic resistance will be randomized. Secondly, the remaining 8 exercises will be randomized. Following each exercise, the patient will rate their perceived level of exertion on the Thera-band® Resistance Intensity Scale for Exercise (RISE).


Eligibility Criteria:
Inclusion Criteria:

* healthy physically active subjects (healthy group)
* patients diagnosed with non-radicular cervical neck pain (neck pain group)
* 18-65

Exclusion Criteria:

* current cervical or upper extremity injury (healthy group)
* history of neck surgery
* corticosteroid treatment within the last two weeks
* radicular signs or symptoms
Patient Satisfaction With Virtual Post Operative Visits: Hip Arthroscopy

This is a prospective, randomized study designed to evaluate the effects of different initial postoperative follow-up modalities. Given the nature of the study, it is not possible for either the surgeons or the subjects to be blinded. Patients will be assigned to either group based on the last digit of their medical record number (MRN). Patients with an even-ending medical record number will be randomized to virtual visit/telemedicine, while patients with an odd-ending medical record number will be randomized to the office visit.

This study aims to evaluate the differences between two forms of postoperative follow-up with respect to patient satisfaction. The primary outcome will be patient satisfaction with their surgeon and with their overall experience. Following their second postoperative visit, the subjects will complete one electronic survey. The survey is designed to assess subject's overall satisfaction and satisfaction with their surgery. This survey is standardized and will be used by both groups.

Eligibility Criteria:
Inclusion Criteria:

* Participants undergoing arthroscopic hip surgery

Exclusion Criteria:

* Age \< 18 years old or Age \> 70 years old
Relationship Between Obstructive Sleep Apnea and Coronary Atherosclerosis

Obstructive sleep apnea (OSA) is a respiratory disorder of sleep characterized by recurrent episodes of complete or partial upper airway obstruction, leading to intermittent oxygen deprivation. This results in sympathetic activation and surges in blood pressure, production of vasoactive substances, as well as activation of the inflammatory and procoagulant pathways. Epidemiological evidence indicates the prevalence of OSA is higher in patients with coronary artery disease than in the general population. The investigators recently showed that 65.7% and 41.9% of the Singapore patients admitted with myocardial infarction were found to have previously undiagnosed OSA and severe OSA, respectively. In a 10-year follow-up epidemiological study, OSA was independently associated with a higher prevalence of fatal and non-fatal cardiovascular events among the otherwise healthy general population. The investigators further showed that in patients who have undergone primary percutaneous coronary intervention for acute myocardial infarction, OSA was an independent predictor of future adverse event rates. Despite the observed association between OSA and adverse cardiovascular outcomes, the underlying pathophysiological mechanisms remain unclear. In this proposal, the investigators aim to elucidate the relationship between OSA and composition of coronary atherosclerotic plaques.


Eligibility Criteria:
Inclusion Criteria:

* Angiogrqaphically documented coronary artery disease
* De novo lesion
* Native coronary artery

Exclusion Criteria:

* known OSA
* intubation and mechanical ventilation
* electrical instability with a high risk of malignant ventricular arrhythmia
* cardiogenic shock
* previous coronary artery bypass surgery
* chronic renal failure on dialysis
* inability to give informed consent
Rehabilitation of the Stroke Hand at Home

The purpose of this research is to evaluate a therapy delivery system for stroke patients that provide accessible, affordable stroke care. User-friendly home therapy robots and a telerehabilitation system are combined to monitor and provide therapy that is accessible for patients in rural and underserved locations. The robotic-based home therapy intervention will produce significantly greater improvement in upper extremity motor function than Usual and Customary Care enhanced with a (non-robotic) home therapy upper extremity rehabilitation program at the end of 8 weeks of home therapy.

The primary purpose of this proposal is to evaluate a combined clinic/home robotic-based stroke therapy delivery and monitoring system in rural and underserved locations that provides accessible, effective and affordable care for stroke survivors with residual limb impairment. The study is a prospective, single-blind, multi-site Randomized Controlled Trial. A total of 96 patients within 6 months post-stroke will be enrolled and randomly assigned to one of two groups: robotic based home therapy or a self administered (non-robotic) home therapy program.

Eligibility Criteria:
Inclusion Criteria:

* Unilateral ischemic or hemorrhagic stroke
* within 6 months of admission to in-patient rehabilitation
* Persistent hemiparesis
* Proximal Upper Extremity voluntary activity
* Preserved cognitive function
* Difficult access to an organized stroke rehabilitation program

Exclusion Criteria:

* Not independent before stroke
* Hemispatial neglect
* Significant other illnesses
Accumulative Effects of Talus Mobilization

The purpose of this study is to verify the effect of anteroposterior talus mobilization on range of motion, pain, and functional capacity in participants with sub-acute and chronic ankle injuries.

The purpose of this study was to verify the acute effect (one session) and chronic (six sessions) and follow-up of the anteroposterior talus mobilization Maitland's grade III on range of motion, pain, and functional capacity in participants with sub-acute and chronic ankle injuries. Thirty eight volunteers subjects (male and female) participated of this study with minimum 18 and maximum 59 years old. The volunteers were allocated in two groups: experimental and control. The variables related to range of motion, pain and functional capacity were measured by biplane goniometer, Visual Analog Scale and Foot and Ankle Ability Measure respectively in four moments: 1- baseline; 2- after the first intervention; 3- after the sixth intervention (two weeks); 4- follow-up (one month). The experimental group received anteroposterior articular mobilization of the talus and the control group received manual contact.

Eligibility Criteria:
Inclusion Criteria:

* unilateral traumatic injury of the ankle with at least two weeks and maximum eight months
* at least a 5º limitation of passive dorsiflexion in comparison to the contralateral side
* do not be under another physical therapy treatment for the lesion
* able to unload partial or total body weight
* do not be in use of analgesic
* provided informed consent after receiving and explanation of all procedures and pertinent information regarding the study

Exclusion Criteria:

* joint blockage by surgical fixation or ankylosis
* presence of vascular, rheumatic, neurological and neoplastic disease in the lower limb
* open or contagious lesion in the ankle region
* pain during palpation in the region anterior of the ankle
Aortic Wall and Left Ventricular Mechanics: Echocardiographic and Hemodynamic Analysis

The purpose of this study is to prospectively determine the relationship between the dimensions of the aorta (the large artery taking off the heart) and blood pressure during cardiac surgery.

The purpose of this study is to prospectively determine the relationship between the dimensions of the aorta (the large artery taking off the heart) and blood pressure during cardiac surgery. Measurements of the aorta are obtained by an ultrasound-based imaging technique called transesophageal echocardiography (TEE), which is routinely performed during cardiac surgery. TEE is an instrument used to monitor the heart and is standard of practice at Weill Cornell Medical College.

Eligibility Criteria:
Inclusion Criteria:

* elective CABG, valvular procedure

Exclusion Criteria:

* non-sinus rhythm (atrial fibrillation, flutter, paced rhythm), pre-operative presence of intra-aortic counterpulsation device, synthetic aortic graft.
Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

This study will evaluate obesity-mediated mechanisms of pancreatic carcinogenesis in minority populations.

This observational study will evaluate obesity-mediated mechanisms of pancreatic carcinogenesis in minority populations consisting of adult males or females, 18 years of age or older, who self-report as African American (AA) or Non-Hispanic White (NHW), and present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor. This study will also include patients who have been previously recruited as part of the FPC study. Our central hypothesis is that adipose tissue (AT) dysfunction contributes to malignant transformation, therapeutic resistance, and poor survival among obese AA pancreatic ductal adenocarcinoma (PDAC) cases and such dysfunction will be characterized by unique biology. The primary objective of this multi-institutional and multidisciplinary translational study is to identify a molecular and imaging profile unique to paired PDAC tumors and AT from AA and harness biological observations to predict therapeutic response and target novel obesity-mediated mechanisms of PDAC development and progression using in vitro, ex vivo, and in vivo techniques and new combinations of drug agents.

Eligibility Criteria:
Inclusion Criteria:

* Adults 18 years of age or older at time of signing informed consent
* Patients who self-report as African American, Non-Hispanic White
* Patients who present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or the University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor.

Exclusion Criteria:

* Patient under 18 years of age
* Has no suspicion or diagnosis of a pancreatic cancer or tumor
* Self-reported race/ethnicity other than African American or Non-Hispanic White.