cyrilzakka/clinical-trials huggingface dataset:
Effects of Transcutaneous Tibial Nerve Stimulation for Overactive Bladder Symptoms in Adults

For overactive bladder symptoms, there are numerous physiotherapy techniques have been found to be beneficial. Transcutaneous electrical stimulation of the tibial nerve is one of those treatment options, that is entirely a non-invasive, easy to apply, and cost-effective technique.

Transcutaneous stimulation of the tibial nerve targets the sacral nerve plexus that contracts the pelvic floor muscles and controls the bladder function.

This research aims to study the effectiveness of transcutaneous tibial nerve stimulation in adults with overactive bladder symptoms along with the conventional physiotherapy for overactive bladder (pelvic floor muscle training through Kegel's exercises) among 60 patients with overactive bladder symptoms on the basis of non-probability purposive sampling technique with screening for study criteria through a consultant urologist. After taking informed consent, all participants will be randomly allocated into two groups. Group A will receive pelvic floor muscles training through Kegels exercises along with transcutaneous electrical stimulation of the tibial nerve and Group B will receive pelvic floor muscles training through Kegels exercises. The treatment duration will of six weeks. Outcomes will be assessed before the start of the treatment and after the end of the treatment sessions.


Eligibility Criteria:
Inclusion Criteria:

* Clinically diagnosed overactive bladder
* A total OABSS score of 3 or more and an urgency score of 2 or more
* 30-65 years old

Exclusion Criteria:

* Pregnancy
* Acute urinary tract infection (within 15 days)
* Any surgical procedure for urinary incontinence
* Genito-urinary cancer history
* Stage II pelvic organ prolapse according to pelvic organ prolapse-quantification system
* Lesion on the site of stimulation or around it
* Pelvic pacemakers
* Lower limbs prostheses
* Patients who will not be able to perform Kegel's exercises
* An impaired sensation at the site of stimulation.
* Patients receiving any treatment other than the prescribed medications by the referring physician (that will be the same for all patients of both groups) will be excluded.
The Effect of Nonstress Test Device Noise Level on Stress Parameters in Primiparous Pregnant Women

Introduction: Prenatal tests can increase the stress levels of pregnant women. One of the tests performed to evaluate fetal health during pregnancy is the Nonstress Test (NST).

Objective: To evaluate the effect of NST device noise level on stress parameters in primiparous pregnant women.

Method: A randomized controlled, prospective study was conducted with 44 pregnant women in a State Hospital in Istanbul/Turkey between 01.02.2021 and 01.10.2021.

Personal Information Form, Spielberger State Anxiety Inventory, Hillrom Welch Allyn Connex Spot Monitor, Gluco Dr Glucometer, Extech SL 400 Personal Noise Dosimeter, Sennheiser HD 450BT ANC Over-Ear Bluetooth Headset, Eppendorf Tube, Philips Avalon FM20 NST were used to collect data. A p value of \<.05 was considered significant in the statistical evaluation.

A number of tests are used to evaluate fetal health during pregnancy. One of these tests is the NST. NST is a frequently used fetal evaluation method in gynecology clinics/services during pregnancy and labor. The sound levels of the NST device are created in a way that the healthcare professional can adjust, and at the same time, the average dB(A) range of the sound levels is not known. It has been stated in many studies that noise causes stress in individuals, and that the stress experienced in pregnant women is associated with negative maternal and neonatal outcomes. It is important to evaluate NST noise levels and stress parameters in order to maintain NST, which is a frequently used fetal evaluation method in the prenatal period in clinical practice, without causing maternal stress and to prevent possible negative consequences. With the information to be obtained in line with the results of the research, it is aimed to maintain the noise level of the NST device used by the midwives in the most appropriate sound range for the pregnant women and thus to ensure that the stress levels of the pregnant women are at the lowest level during the procedure.

This study was carried out to evaluate the effect of NST device noise level on stress parameters in primiparous pregnant women.

Eligibility Criteria:
Inclusion Criteria:

* Voluntarily agreeing to participate in the research,
* Over 18 years old,
* Literate,
* Fluent in Turkish
* 32-42 of your pregnancy. in the week,
* Having a healthy pregnancy,
* No adrenal insufficiency,
* No problems with hearing,
* No psychiatric diagnosis during or before pregnancy,
* No history of infertility,
* Coming to routine pregnancy and NST control,
* Have not had any food or drink for at least two hours before the procedure,
* Primiparous pregnant women without contractions were included.

Exclusion Criteria:

* Pregnant women whose contractions are detected during the NST procedure,
* Pregnant women with deceleration detected in the NST procedure were excluded from the study.
Transcutaneous Electrostimulation for Intermittent Claudication Supervised Walking Therapy for Intermittent cLAudication

Prospective mono-centric trial on patients with peripheral arterial disease and intermittent claudication that receive supervised exercise therapy (group 1) vs. supervised exercise therapy + daily transcutaneous electro-stimulation of the calf muscles.

The investigators conduct a prospective mono-centric trial on all patient with peripheral arterial disease with intermittent claudication that receive supervised exercise therapy (SET) and additional transcutaneous electric stimulation (TES) of the calf muscle. SET program consists in once weekly walking training for 75 min under supervision of a professional trainer. Patients are encouraged to continue the training modules at home. TES is performed using the mobile "Veinoplus arterial" device (AdRem Technology, France) on a daily base for 60-120 min at home. Patient outcome will be compared to the retrospectively analyzed results of patients, that received the same SET program alone in the past.

Eligibility Criteria:
Inclusion Criteria:

* intermittent claudication due to peripheral arterial disease
* ankle brachial index \</=0.9
* occlusion or stenosis of the superficial femoral artery

Exclusion Criteria:

* rest pain or peripheral arterial lesions
* contraindications for supervised walking therapy
* non-vascular conditions that limit patients´ walking ability
* patients that have already received supervised walking therapy
* occlusion of the deep femoral artery
* occlusion or high-grade stenoses of the iliac arteries
* stroke in the last 12 months
* premenopausal women
* diabetes mellitus, dialysis, sclerodermia and other conditions that impair leg perfusion
* active cilostazol therapy or alprostadil-infusion in the last 3 months
* pacemaker, defibrillator systems, life vest
* visible muscle contraction is not achieved without pain
The Correlation of Heart Hemodynamic Status Between 320 Multidetector Computed Tomography, Echocardiography and Cardiac Catheterization in Patients With Coronary Artery Disease

With the advances in multidetector computed tomography (MDCT) technology, CT angiography (CTA) of the coronary arteries using 64-slice or dual-source CT systems has evolved into a robust, alternative, noninvasive imaging technique to rule out coronary artery disease (CAD). Reported sensitivities and specificities of coronary CTA can compete with those of catheter angiography.

Because CT is the major source of ionizing radiation in medicine, dual isotope myocardial perfusion scintigraphy and coronary CTA 16-, 64-slice MDCT and DSCT scanners are associated with the highest amount of radiation dose. Recently, a new generation of MDCT machines with even more detector row (320) has become clinically available. The maximum detector width of 16 cm enables the entire heart to be examined in a single rotation and within a single heartbeat and is expected to substantially reduce artifacts from breathing and body motion. Due to high volume coverage, 320-slice CT machines are able to perform a nonspiral, ECG-gated examination of the heart within a single breath-hold.

The purpose of this study was to investigate the correlation of hemodynamic status of 320 MDCT, echocardiography, and coronary catheterization in patients who suspected coronary artery disease.


Eligibility Criteria:
Inclusion Criteria:

1. Intermediate or high risk for coronary artery disease
2. Healthy volunteers

Exclusion Criteria:

1. Unstable angina
2. Acute myocardial infarction
3. Active cancer status
4. Renal failure(Creatinine \> 1.5 mg/dl)
5. Contrast allergy history
6. Pregnancy
Crestal Bone Level After Allogenic Bone Ring With Simultaneous Dental Implant Placement

This trial is aiming to answer a question whether in Patients with severely atrophied, distal mandibular regions, the use of allogenic bone rings with simultaneous dental implants, compared to autogenous bone rings, give successful clinical and radiographic outcomes without donor site morbidity


Eligibility Criteria:
Inclusion Criteria:

1. Medically free form any systemic diseases that contraindicate the surgical procedures or affect predictable outcomes and non-smoker subjects.
2. Atrophic mandibular distal region requiring vertical augmentation.
3. Good oral hygiene and healthy keratinized mucosa.

Exclusion Criteria:

1. Presence of acute dentoalveolar infection or any pathologic lesions.
2. Totally edentulous patients and patients requiring massive reconstruction and augmentation procedures.
3. Patients with history of previously failed augmentation procedures, or failed implant placement at the intended augmentation region.
Placental Volume, Flow, and Vascularity Study

The purpose of this preliminary study is to implement an automated and standardized computer-based method that accurately measures placental volume, blood flow, and vascularity. This will be accomplished by using the digital data obtained at the time of a first-trimester 3D image volume. This information will then be used to further investigate whether placental volume, blood flow, and vascularity can be used to predict the risk of preeclampsia in conjunction with maternal history and serum blood markers obtained at the time of their ultrasound.

Preeclampsia is defined as a multi-system disorder typically characterized by hypertension, proteinuria, and/or end organ damage. Preeclampsia can develop rapidly at any time after 20 weeks gestation and into the postpartum period and can at times lead to systemic complications and even death. Preeclampsia continues to be a leading cause of maternal morbidity and mortality secondary to the development of hypertensive disorders, systemic inflammatory changes affecting the endothelium, and hemorrhagic complications. It also contributes indirectly to neonatal morbidity and mortality by leading to premature delivery. Our current ability to screen patients for the risk of developing preeclampsia relies on clinical factors as recommended by ACOG and the USPHS. At this time, if a patient is deemed high risk, our only intervention for prevention of preeclampsia is to prescribe low-dose aspirin. Being able to identify the population at higher risk for preeclampsia would allow for implementation of new management options among these persons. The purpose of this preliminary study is to implement an automated and standardized computer-based method that accurately measures placental volume, blood flow, and vascularity. This will be accomplished by using the digital data obtained at the time of a first-trimester 3D image volume. This information will then be used to further investigate whether placental volume, blood flow, and vascularity can be used to predict the risk of preeclampsia in conjunction with maternal history and serum blood markers obtained at the time of their ultrasound.

Eligibility Criteria:
Inclusion Criteria:

* Singleton gestation
* Qualify for a first-trimester screen at the time of enrollment. Criteria for the screen include pregnancy with gestational age between 10 weeks 3 days and 13 weeks 6 days of gestation as well as a crown-rump length between 40 and 84 mm.
* Complete a first-trimester ultrasound at the qualifying M Health Fairview Maternal Fetal Medicine Clinics, which include University Riverside, Ridges, South Dale, and Health East sites
* Provide a blood sample for either completion of the first-trimester screen and/or for the completion of the research study

Exclusion Criteria:

* Multi-fetal gestation or pregnancy with major fetal congenital anomalies and/or known fetal aneuploidy
* Unwilling to complete a first-trimester ultrasound and/or unwilling to provide a serum sample
The Effect of Lidocaine on Smooth Emergence With Double Lumen Tube

Cough suppression during emergence and tracheal extubation from general anaesthesia has become an important issue as part of patient safety. Cough arised from the mechanical irritation of endotracheal tube and cuff could be accompanied by various adverse effects such as laryngospasm, hypertension, tachycardia, arrhythmia and increase of intracranial, intraocular, or intra-abdominal pressure.

Several cough-preventing strategies have been proposed for smooth emergence, such as opioids, dexmedetomidine or lidocaine. Maintenance of remifentanil infusion during emergence has been reported to be an effective method in reducing cough and cardiovascular change without delay of recovery. In previous studies, the effetive effect-site concentraions for 95% of adults (EC95) for preventing cough are a little different depending on anaestheic agent, type of surgery and sex, ranged from 2.14 to 2.94 ng/ml. However, since most of these studies are for sing lumen endotracheal tube, similar preventing effect would not be expected for double lumen tube (DLT) because of its large diameter and long length. Another problem is higher concentration of remifentanil more than 2.5 ng/ml could not guarantee the safety after extubation. The efficacy of a single IV bolus of lidocaine for the prevention of cough has been the subject of numerous trials.

Therefore, combined use of lidocaine and remifentanil could effectively prevent emergence cough for DLT without the risk of high concentration of remifentanil.


Eligibility Criteria:
Inclusion Criteria:

* Patients needs for double lumen tube intubation for one lung ventilation during surgery with ASA (American society of Anesthesiologists) class I or II

Exclusion Criteria:

* Gastroesophageal reflux disease
* Obese patients (BMI \> 30)
* Recent upper respiratory infection history (within 3 weeks)
* Asthma history
* Anticipating difficult airway
Empyema Following Pneumonectomy for Non Small Cell Lung Cancer (NSCLC)

Empyema following pneumonectomy for Non Small Cell Lung Cancer (NSCLC) is a known problem that occurs in about 2% of pneumonectomy patients.

The development of an empyema following pneumonectomy is a devastating complication, especially if associated with an underlying fistula. Whilst the perioperative mortality of pneumonectomy overall is now less than 5%, this rises to around 25% when complicated by empyema, and about 50% when associated with fistula. In addition, there is the morbidity and social cost of long-term drainage, chronic sepsis and often multiple operations.

Eligibility Criteria:
Inclusion Criteria:

* Pneumonectomy for NSCLC

Exclusion Criteria:

* Pneumonectomy for other reasons (infectious pathology, trauma, mesothelioma, ...)
Study Comparing Tigecycline and Vancomycin With Aztreonam in Complicated Skin and Skin Structure Infections

To compare the safety and the efficacy of tigecycline to vancomycin with aztreonam in treating hospitalized patients with complicated skin and/or skin structure infections.


Eligibility Criteria:
Inclusion Criteria:

* Anticipated need for intravenous antibiotic therapy of 5 days or longer.
* Patients known or suspected to have a complicated skin and skin structure infection. Complicated skin/skin structure infection includes infections either involving deeper soft tissue or requiring significant surgical intervention or a significant underlying disease state (such as diabetes mellitus, peripheral vascular disease, peripheral neuropathy, lower venous insufficiency) that complicates response to treatment.

Other inclusion applies

Exclusion Criteria:

* Patients with any concomitant condition that, in the opinion of the investigator, would preclude an evaluation of a response or make it unlikely that the contemplated course of therapy could be completed.
* Patients with severely impaired arterial blood supply and insufficiency such that the likelihood of amputation of the infected anatomical site within one month is likely.
* Infected diabetic foot ulcers or decubitus ulcers where the infection is present for greater than one week's duration or chronically infected decubitus ulcers in patients who can not be compliant with measures necessary for chronic wound healing.
* Necrotizing fasciitis or gangrene.

Other exclusion applies.
Immediate Loading of Implants in the Partially or Completely Edentulous Jaw

The investigators aim to evaluate the biological and mechanical short- and long-term outcome of IL in partially or completely edentulous patients. Moreover, the investigators aim to detect potential influencing risk factors predicting undesirable prosthetic outcome.

Since its introduction in the late 1990s, immediate implant loading concepts (IL) have become a frequent alternative for delayed implant procedures. IL concepts reduce chair time, the number of surgical interventions and pain, and offer instant comfort to the patient. Its reduced treatment time results in obvious socioeconomic advantages. Although there is at present abundant evidence that supports IL, evaluation of long-term biological and mechanical stability outcomes of large patient populations could allow quality improvement and more accurate patient selection. The Departments of Oral and Maxillofacial Surgery and the Department of Dentistry of the General Hospital Saint-John Bruges act as one of the pioneers of IL in Belgium, routinely performing the concept since 2001.

The investigators aim to evaluate the biological and mechanical short- and long-term outcome of IL in partially or completely edentulous patients. Moreover, the investigators aim to detect potential influencing risk factors predicting undesirable prosthetic outcome.

Eligibility Criteria:
Inclusion Criteria:

* patients of all ages
* patients of all genders
* patients with partially or complete edentulous jaw
* patients treated at the department between 01/01/2001 and 31/12/2015

Exclusion Criteria:

* patients not eligible according to abovementioned criteria
* patients who required horizontal bone augmentation procedures of the complete alveolar bone
* patients who required a jaw reconstruction after tumor resection, osteoradionecrosis or medication-related osteonecrosis of the jaw
Endobronchial Valve in Patients With Heterogeneous Emphysema

To compare the clinical outcomes of Endoscopic Lung Volume Reduction using Pulmonx Zephyr Endobronchial Valve (EBV) vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema patients in a controlled trial design setting.

The aim of this prospective, randomized, controlled, one-way crossover study is to assess and compare the efficacy of the Zephyr endobronchial valves vs. Standard of Care (SoC) in patients suffering from COPD with Heterogeneous Emphysema. Patients will be followed up for 6 months after randomization. Patients in the SoC arm will crossover to the EBV treatment arm after the 6-month visit and will be followed up for 6 additional months.The primary objective is the variation of FEV1 between baseline and 3-month follow-up visit. The secondary objectives will evaluate quality of life, exercise capacity, dyspnea (including BODE index) changes, target lobe volume reduction, as well as safety outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Consent form signed
* Heterogeneous emphysema on Chest CT Scanner
* Intact interlobar fissures adjacent to the target lobe on Chest CT or collateral ventilation negative in the target lobe by Chartis assessment
* Post bronchodilator Forced expiratory volume in 1 second (FEV1) \< 50% predicted
* Total Lung Capacity \> 100% predicted
* Residual Volume \> 150% predicted
* PaO2 \> 45mmHg
* Post rehabilitation 6 minute walk test \> 140m
* No COPD exacerbation for at least 6 weeks
* Stopped cigarette smoking for more than 3 months

Exclusion Criteria:

* Contraindication to bronchoscopy
* Tuberculosis, pleural effusion, or clinically significant bronchiectasis
* Lung carcinoma or pulmonary nodule on CT scan requiring Chest CT scan follow-up
* Active pulmonary infection
* Prior lung transplant, LVRS, median sternotomy, bullectomy or lobectomy
* Any extrapulmonary diseases compromising survival or evaluation within the protocol (severe cardiac disease, severe renal insufficiency, cancer...)
* Inclusion in an other study assessing respiratory treatments
* Pregnant or lactating woman
Paracetamol Hypothermia Children

Transient Acetaminophen Induced Hypothermia in Pediatrics Population Undergoing General Anesthesia


Eligibility Criteria:
Inclusion Criteria:

-

Exclusion Criteria:

-
Corneal Elastography and Patient Specific Modeling

The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as LASIK will have their eyes imaged to assess their mechanical properties and will have computational simulations performed to predict the response to treatment. One aim of the study is to test the hypothesis that computational models can predict the cornea's shape changes within clinically acceptable limits of error.

The mechanical condition of the cornea is an important but elusive property of the eye to characterize. Weakness in the cornea is thought to be one of the primary causes of corneal ectasia, a major cause of visual impairment worldwide. Corneal weakness is also important to identify in refractive surgery candidates since such surgeries often involve tissue removal that could lead to corneal instability in certain predisposed patients.

In this study, subjects will undergo imaging with an optical coherence tomography (OCT)-based system to characterize corneal biomechanical properties. In addition, computational representations of the eye will be built from images and interventions will be simulated and compared to actual treatment outcomes. No investigational procedures or study-specific interventions other than imaging are involved.

Eligibility Criteria:
Inclusion Criteria:

* Any patient with keratoconus diagnosed by standard criteria, including topographic steepness, irregular astigmatism with a pattern consistent with keratoconus.
* Any patient deemed a candidate for LASIK (laser vision correction) and scheduled for surgery.

Exclusion Criteria:

* Inability to provide informed consent, including non-English speaking (if interpreter not available) and cognitively/mentally impaired (if legal guardian not available).