cyrilzakka/clinical-trials huggingface dataset:
Compare the Prognostic Differences Between SBRT and Surgery for NSCLC Patients With Interlobular Fissure Invasion.

The goal of this observational study is to compare the prognostic differences between SBRT and Surgery for NSCLC patients with interlobular fissure invasion. The main questions it aims to answer are:

1. Explore the survival differences.
2. Explore of the lung function changes before and after different treatments.

Main purpose:

Explore the survival differences between SBRT and surgery for NSCLC patients with interlobular pleural invasion.

Secondary purpose:

1. Longitudinal exploration of the differences in heart and lung function changes before and after treatment between SBRT and surgery of NSCLC patients with interlobular pleural invasion
2. Longitudinal exploration of dynamic changes in lung lobe volume before and after treatment in NSCLC patients with interlobular pleural invasion treated with SBRT and surgical intervention.

Eligibility Criteria:
Inclusion Criteria:

1. Voluntarily participate and sign an informed consent form in writing;
2. Age 18 and above, regardless of gender;
3. Diagnosed as primary lung cancer through imaging/pathology, meeting the indications for SBRT and surgical treatment;
4. The clinical staging is cIB-IIIB stage (cT2-3N0M0), regardless of whether the staging is overestimated or underestimated as confirmed by pathology;
5. Imaging diagnosis of NSCLC patients with tumor invasion of interlobular pleura;
6. No serious abnormalities in the blood system, heart, lungs, liver, kidney function, or immune deficiency;
7. There are no restrictions on surgical methods, and both VATS and open chest surgery are acceptable;
8. Physical condition score ECOG level 0-2;
9. Expected survival time\>3 months.

Exclusion Criteria:

1. Pathological confirmation of small cell lung cancer;
2. Non solitary lung cancer, non primary lung cancer, with distant metastasis;
3. Individuals with a history of severe lung or heart disease;
4. Severe comorbidities, such as uncontrolled hypertension, heart failure, etc;
5. Pregnant or lactating women;
6. Previous history of malignant tumors;
7. Refusal or inability to sign the informed consent form for participating in the trial.
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing blood pressure and orthostatic tolerance in these patients, and to compare them with those of the standard of care midodrine. The investigators will test the hypothesis that abdominal compression will blunt the exaggerated fall in stroke volume and the increase in abdominal vascular volume during head up tilt.

Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing) due to severe impairment of the autonomic nervous system. Compression garments such as waist-high stockings and abdominal binders have been shown to improve orthostatic hypotension in these patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing blood pressure and orthostatic tolerance in these patients, and to compare them with those of the standard of care midodrine. The investigators will test the hypothesis that abdominal compression will blunt the exaggerated fall in stroke volume and the increase in abdominal vascular volume during head up tilt. This study will help us better understand the contribution of the abdominal veins to orthostatic hypotension and the mechanisms underlying this non-pharmacological therapeutic approach.

Participants will be studied in a tilt table in two separate days in a randomized, crossover fashion with sham abdominal compression (\~5 mmHg) and active compression (\~40 mmHg).

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients,
* between 18-80 yrs.,
* with neurogenic orthostatic hypotension associated with primary autonomic failure (Parkinson Disease, Multiple System Atrophy and Pure Autonomic Failure). Orthostatic hypotension will be defined as ≥20 mmHg decrease in systolic BP or ≥10 mmHg of diastolic BP within 3 minutes on standing associated with impaired autonomic reflexes determined by autonomic testing in the absence of other identifiable causes (Freeman et al., 2011).
* Patients able and willing to provide informed consent.

Exclusion Criteria:

* Pregnancy.
* Significant cardiac, renal or hepatic illness, or with contraindications to administration of pressor agents or external abdominal compression will be excluded.
* Clinically unstable coronary artery disease, or major cardiovascular or neurological event in the past 6 months, and; other factors which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing
Promoting Safer Sex in HIV+ Homosexual and Bisexual Men Who Use Methamphetamine

This project studies the effectiveness of a sexual risk reduction intervention among HIV+ Men who have Sex with Men (MSM) and who use methamphetamine.


Eligibility Criteria:
Inclusion Criteria:

* HIV+
* Men who have sex with men

Exclusion Criteria:
Post-endodontic Pain Survey

As part of root canal treatment, canals should be sealed to prevent further contaminations. There are multiple accepted techniques to fill-obturate canals. In the past, different obturation techniques have been compared. The most current technique used, a single cone with bioceramic sealer, has not been compared. This clinical investigation will compare the postoperative pain of this technique to another common technique used in our clinic. Postoperative pain after one-visit root-canal treatment on teeth with vital pulps: Comparison of three different obturation techniques.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of asymptomatic or symptomatic irreversible pulpitis according to AAE consensus. The diagnosis was based on clinical examinations and confirmed upon accessing the teeth.
* Consenting adults age 18 years and older
* Non-contributory medical history (ASA Class I \& II)
* Included patients were given oral and written information agreed for participation and signed the informed consent

Exclusion Criteria:

* Non-consenting patients and patients below 18 years of age
* Medical history with ASA Class III \& IV
* Non-restorable teeth
* Teeth with a non-vital pulp
* Periodontal probing depths were more than 4mm
* Pre-medication with antibiotics and/or analgesics 24 hours before the treatment
* Patients taking analgesics routinely for non-dental reasons
A Study of Fluconazole in the Prevention of Fungal Infections in HIV-Infected Patients Living in Areas Where Fungal Infections Are Common

To compare the efficacy of fluconazole versus placebo in preventing the development of active coccidioidomycosis and other systemic fungal infections among HIV-infected patients with CD4 lymphocyte counts \< 250 cells/mm3 who are living in the coccidioidal endemic area.

Patients are randomized to receive either fluconazole or placebo daily.

Eligibility Criteria:
Inclusion Criteria

Patients must have:

* Documented HIV infection.
* CD4 count \< 250 cells/mm3.
* No active coccidioidomycosis or other fungal disease requiring systemic antifungal therapy.
* Residence in area considered to be endemic for Coccidioides immitis.
* Consent of parent or guardian if under legal age of consent.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

* Unable to take oral medication.
* Positive serum cryptococcal antigen.

Concurrent Medication:

Excluded:

* Systemic antifungal therapy.

Patients with the following prior conditions are excluded:

History of hypersensitivity to azole or imidazole compounds.

Prior Medication:

Excluded:

* Systemic antifungal agents within 2 weeks prior to study entry.
Evaluation of Pain Intensity During Bone Marrow Biopsy Performed With Inhalation of Pre-Mixed 50 Per Cent Nitrous Oxide and Oxygen Mixture.

Bone marrow biopsy is a painful medical procedure often performed with local anesthetic.

Therefore a double-blind, randomized, controlled trial was carried out in 330 adult patients who where referred for bone marrow biopsy and aspiration. 164 were assigned to inhale an equimolar mixture of nitrous oxide and oxygen and 166 to inhale a placebo. Pain measurement used visual-analogue pain scales, which involve rating the intensity of pain on a horizontal ruler

The efficacy of an inhaled equimolar mixture of nitrous oxide and oxygen to prevent procedural pain during lumbar puncture in children has been demonstrated. In adults the use of an inhaled equimolar mixture could prevent pain.

Although nitrous oxide was initially considered innocuous, evidence began to be gathered later that it had potentially side effect. It has been demonstrated that nitrous oxide inactivates the vitamin B12-dependent enzyme methionine synthetase and impairs DNA synthesis in bone marrow cells.

Therefore this prospective, multicenter randomized placebo controlled, double-blind trial was design to determine whether an inhaled equimolar mixture of nitrous oxide and oxygen would significantly reduce pain during bone marrow biopsy with aspiration. In addition we performed a careful cytological examination of bone marrow samples in order to evaluate the quality of the picture sample.

Eligibility Criteria:
Inclusion Criteria:

* Patients 18 years of age or older
* with a good clinical condition (score ECOG \< 2)
* without contra indication for the use of nitrous oxide or previous medical history of allergy to Xylocaïne.
* Informed consent signed up.

Exclusion Criteria:

* pregnancy,
* prior exposure to nitrous oxide,
* patients with neurological illness and those on anti depressant medications or with congestive heart failure or significant respiratory disease.
* patients on analgesia for other medical conditions or whose with the inability to provided consent of an assessment of pain.
* patients with platelet dysfunction or related coagulation disorders, aspirin or warfarin therapy
Comparison of Sutureless Vs. Standard Biological Prostheses for Surgical Aortic Valve Replacement

Multicenter randomised study which aims to compare sutureless Vs. standard bio- prostheses (1:1) among patients undergoing surgical aortic valve replacement in terms of:

* 6 -month hemodynamic performance.
* 6 month clinical outcomes including all cause mortality, stroke, myocardial infarction, valve reoperation and major/life threatening bleeding
* Cost effectiveness

This study is aimed to compare clinical and hemodynamic performance of conventional sutured stented bio-prostheses among patients undergoing a surgical aortic valve replacement. The prostheses are not pre specified to be provided by a specific manufacturer, so that any bio prosthesis but transcatheter and scentless aortic valves can be implanted.

The estimated sample size is 350 patients. They will be randomised 1:1 to any of the two arms of the study (standard Vs. sutureless prostheses). The randomisation will be stratified according to the need for a concomitant coronary artery bypass grafting procedure.

Six hospitals in Madrid (Spain) will take part in the study. The period of recruitment will start as soon as June 2019 and is supposed to finish by June 2020 or earlier.

The main outcomes of the study will be measured 6 months after the aortic valve implantation

Eligibility Criteria:
Inclusion Criteria:

* Patients older than 18
* Pure aortic stenosis or combined aortic stenosis/regurgitation
* Aortic annulus \>18 mm and \< 27 mm

Exclusion Criteria:

* Pregnancy
* Willing to receive some other prosthesis
* Concomitant surgery of the ascending aorta or left ventricle outflow tract
* Endocarditis
* Emergency
* Some other concomitant procedure
* Participation in any other study
* Previous surgery
Assessment of the Effectiveness of the NECT Program

Self-stigma refers to the transformation process wherein a person's previously held social identity is progressively replaced by a devalued and stigmatized view of oneself termed "illness identity". Self-Stigma is a severe problem in Serious Mental Illness (SMI). Self-stigma prevalence is high (41.7% of the 1229 participants with SZ and 21.7% of the 1182 participants with mood disorders had moderate to high levels of IS in the GAMIAN-Europe study). Self-stigma was negatively associated with self-esteem, social function, wellbeing, quality of life or personal recovery and positively associated with psychiatric symptoms and depression. Several psychosocial interventions (mostly combinations of psychoeducation and cognitive behaviour therapy) have been designed to reduce self-stigma and its impact on clinical and functional outcomes, with preliminary effects on self-stigma, insight and self-efficacy.

Narrative Enhancement and Cognitive Therapy (NECT) is a manualized structured 20-session group-based intervention . Conducted by two trained facilitators the sessions combine psychoeducation, cognitive restructuring and story-telling exercises to reduce self-stigma. Developed in USA, NECT was adapted in Israel and Sweden. NECT showed effectiveness in reducing self-stigma and in improving self-esteem and quality of life. Despite being effective on changing coping strategies, NECT effectiveness on social function is still unclear.

The present study aims to validate NECT French adaptation and to evaluate its effectiveness on social function, self-stigma, psychiatric symptoms, self-esteem, wellbeing, quality of life and personal recovery in SMI participants (schizophrenia, bipolar disorder, borderline personality disorder)


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of schizophrenia, schizoaffective disorder, schizotypal disorder, schizophreniform disorder, bipolar I or II disorder, borderline personality disorder (DSM-V criteria, APA, 2013).
* Clinical stability since 3 months (total PANSS score \<120, MADRS score \<15 and YMRS \<12 for patients with schizophrenia and MADRS score \<15 and YMRS \<12 for patients with bipolar disorder).
* Patients who gave informed consent to participate in the study.
* Affiliated to a social security scheme or beneficiary of such a scheme.

Exclusion Criteria:

* Pregnant or lactating women.
* Criteria relating to the associated pathologies entailing particular risks:
* Neurological disorders of vascular, infectious or neurodegenerative origin.
* Taking somatic drugs with a cerebral or mental impact (eg corticosteroids).
* Presence of an associated intellectual disability.
* Prohibited treatments and procedures:
* Subject in exclusion period of another study.
* Simultaneous participation in other programs having an impact on social functioning or self-stigmatization: remediation of social cognition, individual and group care targeting self-stigmatization and training in social skills.
The Effects of Cannabis on Visual Functions in Healthy and Retinitis Pigmentosa Patients

Medical Marijuana is used widely, and its effects on the visual system and the function of the retina have not been investigated thoroughly. Some evidence suggests that cannabinoids may be beneficial in certain degenerative diseases of the retina.

The purpose of the study is

1. To determine whether cannabis derivatives affect the visual functions in healthy adults
2. To examine the effect of cannabis derivatives on the retina of retinitis pigmentosa patients

Twenty five healthy subjects and 25 retinitis pigmentosa patients will be recruited and will sign an informed consent form. An initial eye exam will include visual acuity and stereo vision, eye movements and eye movement recording, a full slit lamp eye exam, intra-ocular pressure measurement, visual field, OCT and electrophysiology. The subjects will receive a single sublingual dose of cannabis (THC:CBD 1:1, THC 5 mg, or THE:CBD 1:40, THC 5 mg), and will undergo the above examination again. Subjects will be monitored for 5 hours after the administration of cannabis.

Eligibility Criteria:
Inclusion Criteria:

* consenting adults
* generally healthy with or without retinitis pigmentosa

Exclusion Criteria:

* chronic or acute disease other than retinitis pigmentosa
* use of medication
* congestive heart failure
* recent use of illicit drugs (past month)
* history of drug dependency
* history of psychiatric disorder in subject or immediate relatives
* pregnancy
Validation of the French Version of the Hearing Aid Benefit Measurement COSI and IOI-HA Questionnaires

Estimating patient satisfaction is essential in modern day-to-day medical practice. This is particularly true in the field of audiology where evaluating the benefit of patients' devices makes it possible to improve settings and increase patient satisfaction and therefore compliance. Questionnaires measuring hearing aid benefit such as the IOI-HA (International Outcome Inventory for Hearing Aids) and the COSI (Client Oriented Scale of Improvement) are used in everyday practice and promote cooperation between researchers by providing comparable data. Unlike other countries, these questionnaires have never been validated in French by psychometric studies. The objective of this study is to validate the translation of the IOI-HA questionnaire already used in the clinic and to adapt the COSI into French and statistically validate its translation.

Recruitment of cases via the otological consultation of the ENT department, among patients consulting for hearing aids. Inclusion will be suspended once 100 tests and at least 35 re-tests have been completed.

Inclusion (D0):

* Audiometry (as part of treatment)
* Clinical evaluation (as part of treatment)
* Passing the French version of the COSI and IOI-HA questionnaires Visit 1 (D0 +3±1 week): only for 35 patients Second administration of the French version of the COSI and IOI-HA questionnaires either by telephone, or during a second consultation or hospitalization, if this occurs within a compatible time frame.

Eligibility Criteria:
Inclusion Criteria:

* Patients \> 18 years old
* Diagnosis of deafness with unilateral or bilateral hearing aid
* Informed consent to participate in the study
* Good understanding of French
* Non-opposition to participation in the study

Exclusion Criteria:

* Comorbidity that may hamper the interpretation of results (e.g. disabling cognitive disorder)
Does Supplementing of Quadriceps Strength With Exoskeleton After Total Knee Arthroplasty in High Risk Population Reduce Transfer to Extended Care Facility (ECF)

This study involves an exoskeleton which is believed to increase quadriceps muscle strength in the rehabilitation phase after TKA and reduce the discharge the such patients in Extended care facility (ECF) . The purpose of this study is to access efficacy of the robotic exoskeleton device wrapped around the operated knee on patients


Eligibility Criteria:
Inclusion criteria

1. Patients undergoing unilateral primary knee replacement surgery
2. Patients who pre-operatively desire discharged to ECF
3. Patients willing and capable to sign the written informed consent

Exclusion criteria

1. Patients undergoing bilateral primary knee replacement surgery
2. Patients undergoing revision knee replacement surgery
3. Patients who pre-operatively desire discharged to Home
4. Patients not willing and capable to sign the written informed consent
Trial of Quetiapine in Anorexia Nervosa

This research study is being held at UCSD to determine whether the medication Quetiapine helps people suffering from anorexia nervosa by reducing core eating disorders symptoms. This study will see if the medication Quetiapine helps symptoms of anxiety, depression, and obsessionality, in addition to increasing BMI. Men and women between the ages of 18-65 and are currently suffering from anorexia nervosa are needed.


Eligibility Criteria:
Inclusion Criteria:

* Meet criteria for DSM-IV anorexia nervosa (restricting or binge-eating/purging types)
* At least 15% below ideal body weight
* Judged to be reliable to keep clinic visits and able to take all tests and examinations required by the protocol and be able to understand and decide whether or not to sign the Informed Consent.

Exclusion Criteria:

Subjects will not be included in the study who present with any of the following:

* Schizophrenia or schizoaffective disorder (DSM-IV)
* Any ECG abnormality considered clinically significant by the investigator
* Subjects with liver enzymes elevated two times or more above normal
* Other laboratory abnormalities considered clinically significant by the investigator including laboratory deviations requiring acute medical intervention
* Pregnant women, women of childbearing potential not using medically accepted means of contraception (abstinence, IUD, birth control pills, barrier devices or implanted progesterone rods stabilized for at least three months), and lactating women
* Serious suicide risk
* Any medical condition that would preclude the outpatient treatment of anorexia nervosa or the use of quetiapine
* Organic brain disease
* History of severe allergies
* Multiple adverse drug reactions or known allergy to quetiapine
* Use of neuroleptic medications (except benzodiazepines) within 7 days preceding randomization
* History of alcohol or substance abuse disorder as defined in the DSM-IV within the past 3 months.
Evaluation of Emergency Computed Tomography in Suspected Renal Colic. This is an Observational Retrospective Study Aimed to Evaluate Emergency Computed Tomography in Patients At the Emergency Department in Helsingborg, Sweden, with Suspected Acute Renal Colic.

The goal of this observational study is to learn more about diagnostics in patients with suspected acute renal colic at the emergency department. The main questions it aims to answer are:

* How many patients with symtoms of urolithiasis have a stone in the urinary tract at the emergency computed tomography (CT)
* Location and size of the stones.
* Evaluate time to intervention and closure and if this has changed due to emergency CT.

Participants are patients with symtoms of suspected acute renal colic at the emergency department in Helsingborg with an emergency CT within 24 hours.

Since October 2022 The National Guidelines in Sweden recommend emergency CT for patients with suspected acute renal colic at the emergency department. In May 2023 the Department of Urology implemented this new regime with emergency CT for these patients in collaboration with the Department of Emergency and the Department of Radiology. This study aims to evaluate the first year (May 2023 to May 2024) with this new regime. Data regarding these patients where gathered regarding decriptive data, data regarding the stone, interventions and follow up. The investigators aim to compare the data with data from a soon to be published (Scandinavian Journal of Urology) article evaluating the situation regarding these patients during one year 2018-2019.

Eligibility Criteria:
Inclusion Criteria:

* Patient at the emergency department with suspected acute renal colic and an emergency CT within 24 hours 10 May 2023 to 9 May 2024.

Exclusion Criteria:

* None