cyrilzakka/clinical-trials huggingface dataset:
Predictive Factors for a Clinical Diagnosis of Irritable Bowel Syndrome in a Large Cohort of Young Adults.

The prevalence of IBS in the community has been reported in numerous cross-sectional surveys. However, less is known about the incidence of IBS ,mainly due to its slow development and to patients under-reporting. Furthermore, only one study has analyzed data concerning potential risk factors for the diagnosis of IBS. The investigators will examine the incidence of IBS in a large cohort of young adults and will look at the association of socioeconomic, anthropometric and occupational factors with IBS incidence.


Eligibility Criteria:
Inclusion Criteria:

* All Israeli men and women
* aged 18-39 years
* served in active military service (mandatory and career service) between the years 2005-2011

Exclusion Criteria:

* Diagnosis of celiac disease
* Inflammatory bowel disease
* Cancer in the digestive system
Comparison of LMA-Fastrach and I-gel for Blind Tracheal Intubation.

The investigators aim to compare two different types of supraglottic devices for tracheal intubation in patients undergoing elective surgery under general anesthesia.

Our hypothesis is that the use of the I-gel supraglottic airway will result in a higher first attempt success rate of blind tracheal intubation.

Supraglottic airway devices such as LMA-Fastrach and I-gel provide patent airways during general anesthesia.

The LMA-Fastrach is designed to provide a conduit for blind or fiberoptically guided tracheal intubations. However, the success rate of tracheal intubation on the first attempt through this device varies between 50 and 87%.

The I-gel is a newer device for airway management which, with its wide bore, allows direct passage of a tracheal tube. Recent studies suggest that the I-gel is easy to insert and that limited experience is needed before a high success insertion rate is obtained.

In this prospective and randomized study, we will evaluate the performance of both devices for tracheal intubation in patients undergoing elective surgery under general anesthesia.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 and older
* ASA physical status 1-3
* Patients undergoing elective surgery under general anesthesia, requiring endotracheal intubation

Exclusion Criteria:

* ASA physical status 4-5
* Contraindications to muscle relaxation
* Anticipated or known difficult intubation or ventilation
* Patients with limited mouth opening (less than 2 cm)
* Patients at increased risk of aspiration, or having an history of symptomatic gastroesophageal reflux or hiatal hernia.
Postoperative Delirium in the ICU Setting of an Eastern European Centre

The study targets postoperative delirium in patients undergoing major abdominal surgery, with the aim to evaluate the functional baseline and proteomics implicated in pathogenesis, prevention strategies (such as anesthesia depth monitoring) and incidence in certain population groups.


Eligibility Criteria:
Inclusion Criteria:

* ASA risk I-III;
* patients undergoing complex digestive surgery, such as esophagectomy, total gastrectomy, hemicolectomy, cephalic duodenopancreatectomy, hepatic resection.

Exclusion Criteria:

* the impossibility of obtaining the patient's consent/his decisional incapacity;
* patients who underwent neurosurgery for cerebrospinal lesions / cardiac surgery under cardiopulmonary bypass;
* prediagnosed senile/vascular/mixed dementia.
Radiographic and Inflammatory Biomarker Changes in Chronic Low Back Pain

OBJECTIVE: To find and compare the effects of isokinetic training and virtual reality training on pain intensity, trunk muscle strength, radiographical (muscle cross-sectional area and muscle thickness), and biochemical effects in chronic low back pain (LBP) patients.

OBJECTIVE: To find and compare the effects of isokinetic training and virtual reality training on pain intensity, trunk muscle strength, radiographical (muscle cross-sectional area and muscle thickness), and biochemical effects in chronic low back pain (LBP) patients.

METHODS: Randomized, double-blinded controlled study was conducted on 60 LBP patients and they were divided into isokinetic training (IKT; n=20), virtual reality training (VRT; n=20), and a control group (n=20). The VRT group received virtual training for core muscles of the trunk, the IKT group received training for trunk muscles through an Isokinetic dynamometer and the control group received conventional trunk balance exercises. Pain intensity (visual analog scale -VAS), trunk muscle strength, radiographical (muscle cross-sectional area through Magnetic resonance imaging - MRI \& muscle thickness through Ultrasound - US), and biochemical (CRP, TNF-α, IL-2, IL-4, IL-6) variables were measured at baseline and after 4 weeks (short term effect) of training.

Eligibility Criteria:
Inclusion Criteria:

* University male football players
* Age group of 18 - 25 years
* chronic (≥3 months) LBP,
* 4 to 8 pain intensity in visual analog scale (VAS).

Exclusion Criteria:

* Participants with severe musculoskeletal, neural, somatic, and psychiatric conditions,
* Waiting for spine surgery,
* Having alcohol or drug abuse,
* Involved in other weight and balance training programs.
* Participants with other soft tissue injuries, fractures in the lower limbs and pelvic bone, deformities.
Improving Emotion Regulation Flexibility: Testing the Efficacy of an Emotion Regulation Program in College Students

The main objective of this RCT is to test the efficacy of an emotion regulation group program (i.e., ART program) in college students, compared to an active control group (i.e., relaxation program). Using multilevel analyses, we expect an improvement in anxious-depressive symptomatology for both groups. However, we expect the ART group to improve specifically on emotion regulation flexibility ability, and the last to be a mediative variable on mental health.

Emotion regulation (ER) is a process associated with difficulties in mental health. Given its transdiagnostic features, its improvement could facilitate the recovery of various psychological issues. A limit of current studies is the lack of knowledge regarding whether available interventions improve ER flexibility (i.e., the ability to implement ER strategies in line with contextual demands), even though this capacity has been associated with better mental health and well-being. Therefore, the aim of the study is to test the efficacy of a 9-weeks ER group program (the Affect Regulation Training-ART), using the most appropriate measures (i.e., experience sampling method) in a student population. Plus, the goal of the study is to explore the potential mediative role of ER flexibility on mental health improvement.

This RCT will compare the ART program group to an active control group (a relaxation program) in 100 participants. To test the mediative role of ER flexibility on mental health, daily measures will be used before, during, and after the interventions to evaluate the extent to which participants are flexible in their ER.

Using multilevel analyses, we expect an improvement in anxious-depressive symptomatology for both groups. However, we expect the ART group to improve specifically on ER flexibility ability, and the last to be a mediative variable on mental health.

This study will enhance knowledge on interventions for students and the impact of interventions on ER flexibility. Also, this research will improve knowledge on ecological measures for assessing the effect of interventions. Overall, this project represents new opportunities to improve ER skills to improve mental health in undergraduate students.

Eligibility Criteria:
Inclusion Criteria:

* Grenoble Alpes University student
* Having a smartphone that can host PIEL application
* BDI ≥ 10 and ≤ 30
* Reading, understanding, and speaking French
* Signed free and informed consent

Non inclusion Criteria:

* Participation in another study related to emotion regulation
* Participation in other psychotherapies involving cognitive and behavioral intervention (actual or in the past year)
* Changes in drug treatments in the last two months
* Student in psychology
* Individuals concerned in the articles L1121-6 à L1121-8 of CSP (i.e., protected individuals)
* Suicidal risk (BDI II, item suicidal thoughts \> 1 or MINI suicide, low intensity)
* Anorexia nervose (MINI)
* Schizophrenic spectrum disorder (MINI)
* Substance abuse (heroin, cocaine, ecstasy) (MINI)
EMPower: Electronic Media Powering Positive Health Changes in Youth

The purpose of this study is to evaluate the effectiveness of a technology-based behavioral Healthy Lifestyle intervention on adiposity (body mass index z-score), blood pressure (mean clinic systolic BP), and heart size (LVM) in comparison to standard care.


Eligibility Criteria:
Inclusion Criteria:

* Overweight or Obese
* Speaks English

Exclusion Criteria:

* No smart phone / smart phone data plan
* Not willing to send/ receive text messages or download and use the study applications
* Neurological impairment/ developmental delay
* New / changes in anti-hypertensive medication or medication known to affect blood pressure within the last 6 months
* Prior diagnosis of congenital heart disease or cancer
* Pregnancy
* Taking medication with weight gain as a side effect
* Taking medications for weight loss/ participation in another weight loss program
Patogenic Mutation in 5 Genes

This is a pathogenic mutation profile of colorectal patients specifically in 5 genes, i.e. APC, TP53, PIK3CA, KRAS, and MLH1. Single nucleotide variants identified were synchronized with patients' characteristics.


Eligibility Criteria:
Inclusion Criteria:

* FFPE samples fullfilling purity criterion and pass quality control

Exclusion Criteria:

* none
Point of Care, High Resolution and 3-Dimensional Ultrasonography

The overall purpose of this study is to establish an ultrasound technique to aid in oral and dental examination of soft and hard tissues. Ultrasound is currently not used in Dentistry and associated oral examinations and we are exploring its usefulness for clinical practice. This study will investigate the use of ultrasonic imaging for planning and placing dental implants, as well as evaluate the use of ultrasonic imaging for monitoring marginal bone loss around dental implants.


Eligibility Criteria:
Inclusion Criteria:

* Aged 18 years or older
* • Have a dental implant infection (bleeding on probing/exudate and probing depths of at least 5 mm) and are or will be scheduled for revision surgery within 90 days of the screening visit.
* Willing to comply with all study procedures and be available for the duration of the study.

Exclusion Criteria:

* Unwilling or unable to read and sign informed consent form.
* Pregnancy or unsure of their pregnancy status (self-reported)
Treatment Education for Perinatal Women and Their Community Support

The study evaluates the feasibility and acceptability of a 50 minute treatment education session for perinatal women with opioid use disorder and a community support person. The education session provides correct information about opioid agonist medications and neonatal abstinence syndrome.

Perinatal women with opioid disorder often face criticism by social network members for receiving opioid agonist treatment. Feeling stigmatized by others may impact willingness to start and remain in agonist treatment.

The present study evaluates the feasibility and acceptability of a 50 minute treatment education session for perinatal women who are treated using an agonist medication (methadone or buprenorphine) and community support chosen by the patient.

Study participants will be recruited from perinatal women who receive substance abuse treatment at the Center for Addiction and Pregnancy or Addiction Treatment Services at Johns Hopkins Bayview campus. These women will work with a counselor to select a community support person to bring to the program for the education session.

The session will provide correct information on opioid agonist medications and neonatal abstinence syndrome. This session will follow a structured outline.

Eligibility Criteria:
Inclusion Criteria:

* perinatal women treated with agonist medication
* interest in study participation
* interest in community support:
* interest in study participation

Exclusion Criteria:

* perinatal women not treated with agonist medication
* not interested in study participation
* not interested in community support:
* not interested in study participation
Effectiveness of Closed Loop Stimulation (CLS) With His Bundle Lead Placement

This study is a prospective, non-randomized pilot study looking to evaluate the effectiveness of Closed Loop Stimulation (CLS) in sinus node dysfunction patients with HIS bundle placement. Patients with sinus node dysfunction who have previously received a Biotronik pacemaker with His bundle lead placement as part of routine care will be recruited for the study. A hand-grip exercise will be performed at the conclusion of bicycle exercise testing in order to assess the performance of CLS during isometric exercise. After the study exercise testing is completed, data will be collected from the pacemaker.


Eligibility Criteria:
Inclusion Criteria:

* Documented sinus node dysfunction
* Biotronik pacemaker implanted with His bundle lead placement for standard indications
* Implanted at least 30 days
* CLS has been enabled for at least 7 days or will be programmed ON for at least 7 days prior to exercise test
* Leads and device are functioning appropriately

Exclusion Criteria:

* Inability to complete treadmill/bicycle exercise test
* Planned surgical revision or replacement of the device and/or leads
* Patients who are unwilling or unable to provide informed consent
Herbal Patch for Overactive Bladder

Overactive bladder is a clinical syndrome characterized by frequency, with or without urge incontinence, urgency, and nocturia, which affect patients' sleeping quality and rehabilitation program progressing. Current treatments include behavioral therapy (eg, life style adjustment, bladder training, pelvic floor muscle therapy) and medication. Antimuscarinic agents is the most common medications prescribed for OAB, but patients often have side effects like dry mouth and constipation. And there were plenty of herbal medicine which are beneficial to urine frequency and voiding dysfunction in ancient Chinese medicine books and records. In human trial, 62 Subjects diagnosed as overactive bladder will be enrolled and treated with Cinnamon patch. After treatment we will estimate the efficacy and record adverse events to conduct statistically analysis.

Overactive bladder is a clinical syndrome characterized by frequency, with or without urge incontinence, urgency, and nocturia, which affect patients' sleeping quality and rehabilitation program progressing. Current treatments include behavioral therapy (eg, life style adjustment, bladder training, pelvic floor muscle therapy) and medication. Antimuscarinic agents is the most common medications prescribed for OAB, but patients often have side effects like dry mouth and constipation. And there were plenty of herbal medicine which are beneficial to urine frequency and voiding dysfunction in ancient Chinese medicine books and records. In human trial, 62 Subjects diagnosed as overactive bladder will be enrolled and treated with Cinnamon patch. After treatment we will estimate the efficacy and record adverse events to conduct statistically analysis.

The 1st year project: (1) Expect to enroll 62 clinical subjects of OAB. (2) Evaluate subjects 'symptom and proceed patch treatment. (3) Record treatment responses including adverse effect. (4) Conduct statistically analysis.

The 2nd year project: (1) Completing enrollment of 62 clinical subjects of OAB. (2) Finish evaluation and treatment of all subjects. (3) Statistically analysis all collecting data (4) Discuss and analyze the outcome.

Eligibility Criteria:
Inclusion Criteria:

* urgency score of OABSS ≥ 2 or total score of OABSS ≥ 3

Exclusion Criteria:

* suffering from acute urinary tract infection
* recurrent urinary tract infection ≥ 5 times in the last year
* Hematuria or bladder stone disease
* using foley catheter
* Pregnant or breastfeeding women
* Spinal cord injury patients
* Mental illness or substance abuse
* taking medicine for the treatment of overactive bladder within one month
Investigating the Impact of Nudging Cardiologists to Prescribe Guideline-directed Medical Therapy in Heart Failure Patients

This study investigates the impact of a nudge-based intervention on improving guideline directed medical therapy (GDMT) prescription among cardiologists. Using a stepped wedge randomized controlled trial design, we assess whether digital decision support-leveraging home monitoring and clinical data-enhances adherence to guideline-recommended medication titration. The primary outcomes include HF related hospitalization rates and all cause mortality.


Eligibility Criteria:
Inclusion Criteria:

* All heart failure diagnoses
* \>18 years

Exclusion Criteria:

* Not understanding the Dutch Language.
* Allergies that make uptitration impossible.
* Admission to hospice or palliative care.
* Severe psychological disorders.
Efficacy Study of LY2422347 to Treat Insomnia

The purpose of this study is to determine whether a compound known as LY2422347 is effective in treating people diagnosed with primary insomnia (difficulty sleeping with no other significant contributing factor, such as depression).


Eligibility Criteria:
Inclusion Criteria:

* must have been diagnosed with primary insomnia
* must not be significantly overweight
* must be able to visit the study doctor's office once every 2 weeks for 8 weeks and willing to use a handheld electronic device as a sleep diary every day
* must be able to read and speak in English and be able to see well enough to use the handheld electronic device
* the patient's answer to the question "During the past month, how would you rate your sleep quality overall?" must be either "Very Bad" or "Fairly Bad"

Exclusion Criteria:

* cannot have a clinically significant and/or uncontrolled condition or other significant ailment including restless leg syndrome (RLS) or periodic limb movement disorder (PLMD)
* cannot have obstructive sleep apnea (OSA), or be considered by the study doctor to have probable OSA based upon patient history and physical examination
* cannot be currently using antidepressants, antipsychotics, stimulants, antihistaminics, or other medications that are known to effect sleep
* cannot have a current or previous major psychiatric disorder (other than insomnia) such as depression, schizophrenia, bipolar disorder, social anxiety, or another psychotic disorder.
Nutritional Supplement for Patients With Severe Infection

This is a randomized trial testing a supplement that has been approved by Health Canada to support healthy cholesterol levels (i.e. high density lipoprotein (HDL) cholesterol). This trial is proposing to use this approved supplement to determine whether it is able to raise HDL cholesterol in patients treated in the intensive care unit (ICU) with severe infection who have detrimentally low levels of HDL cholesterol. Patients who present to the ICU with severe infection will be approached for consent. If they choose to participate, patients will be given usual care or a 150mL daily nutritional supplement containing lauric acid (15 ml) and Berberine (1000 mg) daily for 14 days. Participants will be followed during their stay in the ICU and will receive follow up phone calls at Day 28 and 90.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of Sepsis
* plasma high density lipoprotein levels less than 1 mM
* receiving enteral nutrition

Exclusion Criteria:

• known pregnancy/intending to get pregnant within 28 days of enrollment in study
The Effect of 10-Week Exercise Training on Children With Asthma

The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma


Eligibility Criteria:
Inclusion Criteria:

* Good health
* Physical activity
* No evidence of disease or disability
* Diagnosed with persistent asthma (asthma subjects)
* BMI\<95 percentile

Exclusion Criteria:

* Use of illegal drugs or alcohol
* Very high physical fitness
* Pregnancy
* More than two asthma attack per week (asthma subjects)
Efficacy of Topical Cyclosporine A for Treatment and Prevention of Graft Rejection in Corneal Grafts With Previous Rejection Episodes

The use of topical Cyclosporine A early after an episode of endothelial graft rejection after penetrating keratoplasty and continuing its administration for 6 months can reduce the course of that episode and recurrence of the rejection.


Eligibility Criteria:
Inclusion Criteria:

* Penetrating keratoplasty in eyes without vascularization

Exclusion Criteria:

* History of previous intraocular surgery
CUHK Jockey Club Tech-based Stroke Rehabilitation Programme - ARR

The Hong Kong Jockey Club Charities Trust has supported CUHK to launch a three-year project 'CUHK Jockey Club HOPE4Care Programme' to implement four evidence-based advanced rehabilitation technologies in 40 local elderly day care centres and rehabilitation centres, to benefit the community.

Our research team had developed the "Augmented Reality (AR) Rehabilitation Training System" that can be used as tools for rehabilitation by individuals who have suffered from a stroke or elderly. The system facilitates an active rehabilitative exercise.


Eligibility Criteria:
Inclusion Criteria

* Diagnosis of ischemic brain injury or intracerebral haemorrhage shown by magnetic resonance imaging or computed tomography after the onset of stroke;
* Motor impairment in upper-limb, lower-limb, and/or balance;
* No or mild spasticity on the lower-limb or upper-limb (MAS≤2);
* Have sufficient cognition to follow the instructions provided by the rehab system.

Exclusion Criteria

* Any additional medical or psychological condition that would affect their ability to comply with the study protocol, e.g., a significant orthopaedic or chronic pain condition, major post-stroke depression, epilepsy, artificial cardiac pacemaker / joint;
* Severe shoulder or arm contracture/pain;
* Severe knee or hip contracture/pain
* Pregnant women