cyrilzakka/clinical-trials huggingface dataset:
To Determine the Efficacy of Neurokinin 1 Receptor Antagonist as a Therapeutic Tool Against Cytokine Storm and Respiratory Failure in Covid-19 Patients

This is a randomized, randomized controlled trial to investigate the efficacy and safety of Neurokinin-1 Receptor (NK-1R) 80 mg orally given daily to treat cytokine storm causing inflammatory lung injury and respiratory failure associated with severe or critical COVID-19 infection. NK-1R is the receptor of Substance P (SP) and responsible for its functionality. Here, we propose that SP via its tachykinin receptor, NK-1R may cause inflammation in Covid-19 infection. It may initiate the cytokine storming via binding to its receptor NK-1 and many inflammatory mediators are released. If SP release is reduced by NK-1R antagonist, it may control the cytokine storming and hence the hyper-responsiveness of the respiratory tract through reduction in cytokine storming It may serve as the treatment strategy for Covid-19 infected patients.

Patients fulfilling the inclusion criteria will be enrolled after giving consent. They wll be randomized to treatment with either NK-1R antagonist or placebo in addition to Dexamethasone as a standard treatment given to both groups for Covid-19 infection as per the protocol at the treating hospital. Inflammatory lab markers as detailed should be collected once per day in the morning, preferably at the same time every morning. All enrolled participants will have whole blood collected for whole genome sequencing.

Objective:

To evaluate the clinical outcomes of Neurokinin 1 Receptor antagonist in Covid-19 patients against the usual treatments as controls

Dosage Aprepitant capsules may be given to patients from 3-5 days fosaprepitant dimeglumine (Injection 115mg, prodrug form of aprepitant) may be substituted for oral drug in case of critical patients May be taken with or without food

Administration One capsule of Aprepitant once a day for 3-5 days

Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 yrs
* Both genders
* Lab Confirmed COVID-19 infection by PCR or plasma positive of specific antibody against COVID-19
* In hospital treatment ≥ 72 hours
* Admitted patients
* Severe Disease (Respiratory rate \>=30/min; or (b) Rest SPO2\<=90%; or (c) PaO2/FiO2\<=300 mmHg) or
* Critical Phase (Respiratory failure and needs mechanical ventilation; or Shock occurs; or Multiple organ failure and needs ICU monitoring)

Exclusion Criteria:

* Patients who are not willing to give consent
* known HIV,HBV, HCV infection
* pregnancy
A Decade of Sleeve Gastrectomy: Analysis of Short and Long-term Outcome of 562 Patients

Obesity is a chronic disease and its treatment requires close follow-up to accurately assess the efficacy and durability of any treatment strategy. It is widely accepted that bariatric surgery patients require lifetime follow-up to assess for weight loss, co-morbidity changes, and nutritional deficiencies.

The study objective was to ascertain efficacy of weight loss and complication rates in 562 consecutive cases of laparoscopic sleeve gastrectomy (LSG) in a single surgeon practice.

Obesity is a major healthcare problem reaching epidemic proportion and affecting people of all age (1). The only treatment that proven effective option for a significant substantial long-term weight loss and that cures or durably improves comorbidities is still bariatric surgery (2, 3). Because obesity is a chronic disease, it is widely accepted that to accurately assess the efficacy and durability of any type of bariatric surgery requires lifetime follow-up to assess for weight loss, co-morbidity changes, and nutritional deficiencies.

Despite initially performed as a first part of the staged procedures, the laparoscopic sleeve gastrectomy (LSG) has since introduced as a stand-alone bariatric operation associated with good, short and mid-term weight loss and satisfactory complication rates when conducted in experienced hands. Although simplicity and the overall efficacy of the procedure supported by meta-analysis and systematic review (4, 5), there are still limited long-term outcome data (6). Due to publication bias or multiple controversies regarding the technique of LSG, some of the available data may have underreported which has also been resulted in questioning the long-term weight loss efficacy of the procedure.

Although addressed by a recent consensus document,12 there are multiple controversies regarding the technique of LSG, and this may in part be what has led to the variable published results.

The study objective was to assess the long-term (≥ 5 years) as well as short (1 to ≤ 3 years) and mid-term (\> 3 to \< 5 years) results in regard to the BMI change, resolution of co-morbidities and complications in 562 consecutive morbidly obese patients undergoing LSG as a primary procedure.

Eligibility Criteria:
Inclusion Criteria:

* underwent LSG for morbid obesity and related morbidities as a primary procedure

Exclusion Criteria:

* previous history of obesity surgery
The Effect of Serious Game and Video-Assisted Education on Nursing Students

Aim: This study was conducted to evaluate the effect of a serious game and video-assisted training program developed for parenteral drug administration education on nursing students' psychomotor skill development, perception of clinical stress, satisfaction, and self-confidence in learning.

Material and Method: The study was carried out as a randomized controlled experimental research design between June 2023 and April 2025 at the Faculty of Nursing, İnönü University. All students enrolled in the Nursing Department during the Spring Semester of the 2023-2024 academic year constituted the study population. The sample consisted of 99 students (33 in the serious game group, 33 in the video group, and 33 in the control group), determined by power analysis. Data were collected using the "Psychomotor Skills Evaluation Checklists," the "Perceived Stress Scale for Nursing Students," and the "Student Satisfaction and Self-Confidence in Learning Scale."

Serious games help to develop participants' problem solving, critical thinking and communication skills, while enriching the learning experience. Serious gaming is a learning-first approach that mimics reality using virtual simulation. These games can be used to optimise the acquisition of clinical skills, stimulate student motivation by completing the simulation and allow teachers to assess students' progress.Video-assisted learning provides learners with a visual tool that facilitates the understanding of abilities and skills. It is often used to illustrate how a teacher or expert addresses a topic, process or skill. The content can then be followed, learnt and applied by learners. In this study, both methods were evaluated together and their effects on the development of nursing students' competencies for parenteral drug adminstrantion practices were evaluated

Eligibility Criteria:
Inclusion Criteria:

* Being a 1st year nursing student,
* Receiving training on parenteral drug applications for the first time,
* Not having any physical disabilities related to vision, hearing and motor skills,
* Having a smart mobile phone with Android/IOS operating system, and
* Volunteering to participate in the study.

Exclusion Criteria:

* Students who made vertical transfer to the department with DGS because they may have taken the subject of parenteral drug applications in an associate degree programme before,
* Students who did not have a smart mobile phone with Android / IOS operating system and
* Students who did not volunteer to participate in the study were excluded from the study.
RSA vs. Nonop for 3 & 4-Part Proximal Humerus Fractures

There is currently no consensus amongst orthopedic specialists on the best way to treat 3- and 4-part proximal humerus fractures. No surgery and surgery with a type of shoulder replacement called a reverse total shoulder arthroplasty are two options that many orthopedists use. This study is being performed to evaluate the differences in short- and long-term pain and functional outcomes between patients who are treated with these two different options.


Eligibility Criteria:
Inclusion criteria

* Displaced 3- and 4-part proximal humerus fractures.
* Age greater than or equal to 65 years old.

Exclusion Criteria

* Less than 65 years old.
* Medical comorbidities precluding surgical treatment or anesthesia
* Dementia or inability to provide adequate follow up.
* Pathologic fractures
* Open fractures
* Associated injuries: fracture dislocations, multiple or complex injuries of the ipsilateral limb, complete brachial plexopathy, vascular injury and polytrauma.
A Biomarker Screening Protocol for Participants With Solid Tumors

Biomarker Screening Protocol for Preliminary Eligibility Determination for Adoptive T-cell Therapy Trials:This is a decentralized, multi-site, US-based biomarker screening study to identify participants who have specific disease indications and tumor expression of target(s) of interest that may inform eligibility for active and future Lyell clinical trials. No investigational treatments will be administered in this non-interventional screening study. Only previously obtained archival tumor tissue will be allowed on this study for biomarker analysis. Fresh tumor biopsies are not permitted on this study. The study will be conducted virtually and participants will utilize telehealth and e-consent modules. If participants tumors express the biomarkers of interest they can be referred to open and enrolling clinical trials. Participation on the screening study does not guarantee enrollment or treatment on an interventional clinical trial.


Eligibility Criteria:
Inclusion Criteria:

1. Participants aged ≥ 18 years at time of informed consent
2. Able to provide informed consent
3. Histologically or cytologically confirmed diagnosis of advanced or metastatic solid tumor malignancy.The Sponsor will indicate which solid tumor disease indications are open to enrollment.
4. Ability to provide a tumor tissue sample collected within 3 years prior to enrollment. The sample must consist, at minimum, of 5 freshly cut, unstained 4-5 μM sections cut from a formalin-fixed paraffin-embedded (FFPE) tissue block. The sample must contain sufficient tumor tissue to allow for the evaluation of biomarker expression

Exclusion Criteria:

1. Prior solid organ transplantation
2. Prior treatment with any adoptive cell therapy
3. Uncontrolled medical, psychological, familial, sociological, or geographical conditions that do not permit compliance with a clinical study, as judged by the Investigator or Sponsor's Medical Monitor
Selective Head-and-neck Cooling on Biomarker Levels and Symptom Rating Following a Boxing Bout

Young, healthy elite boxers ≥ 18 years old are recruited. Prior to, and immediately after a competitive boxing bout over 3x2 or 3x3 minutes, blood samples are drawn. Boxers are randomized to intervention or control management by 1:1 allocation prior to baseline testing. After the initial post-fight blood sample is drawn and symptom rating using the sports concussion assessment tool-5 (SCAT-5) has been collected, the boxers receive either acute selective head-and-neck cooling for 45 min, or routine post-fight management. The number of head impacts are counted in all boxers on match video recordings. In both groups, blood samples are drawn 45 minutes after the initial post-bout blood sample, as well as 3 and 6 days post-fight.


Eligibility Criteria:
Inclusion Criteria:

1. Male and female elite boxers ≥18 years old
2. Cleared for participation by the medical staff of the Swedish Boxing Association.
3. Informed consent by each participant prior to the competitive event
4. No boxing fights or match sparring during the initial 6 days after their last boxing fight
5. Signed informed consent.

Exclusion Criteria:

1. \>40 years old or \<18 years old
2. Participation in competitive fights, match-sparring or any training causing additional head impacts during the first six post-fight days after being included in the study.
3. History of autoimmune neurological diseases or a neurodegenerative disorder.
4. History of previous traumatic brain injury resulting in an intracranial haemorrhage.
Comparison of the Effect of Cervical Mucus Cleaning Method Applied Before Embryo Transfer on Pregnancy Rates.

To assess the impact of cervical mucus cleansing before embryo transfer and compare two different instruments for this purpose.

All patients will be informed about the study and those who give written consent will be included in the study.

Women undergoing good quality embryo transfer will be assigned to one of the 3 arms of the study according to the previously determined randomization chart. The first evaluation of the patient will be made on the 12th day after embryo transfer. Pregnancy status will be evaluated with serum βhcg value. If pregnancy is confirmed by serum βhcg value, fetal viability will be evaluated by ultrasound 4 weeks after transfer.

Eligibility Criteria:
Inclusion Criteria:

* 21-40 years old women,
* Women undergoing good quality embryo transfer,
* Women who are eligible for a single or double embryo transfer.

Exclusion Criteria:

* If there is a diagnosis of a uterine anomaly,
* If there is a diagnosis of myoma uteri,
* If there is a diagnosis of rheumatological disease,
* Women to be transferred other than good quality embryo,
* Hİstory of previous pelvic, gynecological operation.
Local Anesthesia Before Bulkamid Injection

While recommended pre-anesthesia for polyacylamide hydrogel (PAHG, Bulkamid) injections for stress urinary incontinence and intrinsic sphincter deficiency can include intraurethral anesthetic gel with or without periurethral block, there is no existing literature to guide choice of anesthesia. This is a single-blinded randomized control trial to evaluate post-procedure pain with choice of anesthesia before PAHG injection.


Eligibility Criteria:
Inclusion Criteria:

* Women ≥ 18 years old with stress urinary incontinence, intrinsic sphincter deficiency, or stress-predominant mixed urinary incontinence desiring PAHG
* English-speaking
* Scheduled in outpatient clinic or OR without sedation, general, or neuraxial anesthesia

Exclusion Criteria:

* Pregnancy
* Neurogenic bladder
* Pre-existing need for intermittent catheterization or indwelling catheter
* Bladder or urothelial malignancy
* Prior radiation to pelvic floor
* Known allergy/sensitivity to PAHG
Psychiatric and Social Impacts of IVF

To asses psychiatric impacts of In vitro fertilization.

Infertility and its treatment represent a global health area of increasing importance. Individuals experiencing infertility represent around 8-10% of couples worldwide.

The demand for assisted reproduction techniques such as in-vitro fertilization (IVF) has increased in developed countries over the past decades, and is predicted to increase further in those to come .

This could be further boosted by numbers in resource-limited settings of the developing world, where an estimated 180 million couples are experiencing infertility.

The efficacy of IVF among the assisted fertility options has led an increasing number of individuals to seek this specific treatment. More than a half million babies are now born each year from IVF, as a result of over two million estimated annual treatment cycles . Yet it is also a relatively invasive and disruptive process that can be both physically and psychologically demanding .

Infertility itself has been associated with a higher prevalence of depression and anxiety, lower quality of life, and lower self-esteem .

The IVF process-which includes injectable medication and multiple blood tests, clinic appointments and procedures, waiting periods and anticipation of outcomes at each phase-may lead to further psychological stress. This can be exacerbated by disturbances to an individual's work and routine and the financial pressure of this costly treatment , and may be worse after multiple failed cycles .

Eligibility Criteria:
Inclusion Criteria:

* Couples who perform or planning or failed to perform in vitro fertilization.
* Age from 18y To 40y .

Exclusion Criteria:

* Couples with any Psychiatric disorders prior to marriage.
* Couples with any physical or mental handcapes.
* refusal of couples to give consent to join the study.
Role of Bile Duct Resection in Major Hepatectomy Due to Intrahepatic Cholangiocarcinoma

To investigate the prognosis due to presence or absence of bile duct resection in intrahepatic cholangiocarcinoma that require hepatic lobectomy.

The bile duct resection in hepatic lobectomy due to cholangiocarcinoma, mass forming type, is still controversial. We retrospectively evaluated the effect of bile duct resection in this surgery.

Eligibility Criteria:
Inclusion Criteria:

* Cases of major hepatectomy due to intrahepatic cholangiocarcinoma

Exclusion Criteria:

-
The Applying of Acupressure and Abdominal Massage to Improving Constipation in Stroke Patients.

Experimental research design with two-group repeated-measure design. Experimental group was pressing the Hegu (LI 4), Zusanli (ST 36) , Tianshu(ST 25) and abdominal massage for eight minutes total, press once in the morning and afternoon, seven days total and two days for follow the trail. Control group was pressing sham ponits. Research tools to self semi-structured questionnaire collected data on patient's diet, activity, medication, defecation patterns, subjective defecation feelingauscultation bowel sounds like.

Experimental research design with two-group repeated-measure design. The investigators estimate there are recruit fifty patients from related rehabilitation hospital of a medical center in Taichung, central Taiwan, using randomization put patients in experimental group and control group. Experimental group Pressing the Hegu (LI 4), Zusanli (ST 36) , Tianshu(ST 25) and abdominal massage for eight minutes total, press once in the morning and afternoon, seven days total and two days for follow the trail. Control group was pressing sham ponits. Research tools to self semi-structured questionnaire collected data on patient's diet, activity, medication, defecation patterns, subjective defecation feelings, and auscultation bowel sounds like. The investigators expected the results of this study can provide clinical nursing care for stroke patients of reference, to improve quality of care, and increase acupressure to improve the empirical data of stroke in patients with constipation.

Eligibility Criteria:
Inclusion Criteria:

1. patients who were diagnosed as stroke, and in stability phase.
2. patients who had constipation symptoms.
3. patients whose platelets counts more than 150,000 / μ.

Exclusion Criteria:

1. Consciousness is not clear.
2. The physician diagnosed with irritable bowel syndrome.
Almond Butter and Fasting Glucose

A two-period randomized crossover study will be conducted to determine the effect of almond butter as an evening snack on fasting blood glucose in adults with type 2 diabetes, not taking insulin.

Control of fasting blood glucose is a challenge for many individuals with diabetes. Researchers want to better understand how a nighttime snack can affect morning fasting blood glucose. A two-period randomized crossover trial will be conducted. Participants will be randomized to receive each treatment for 1 week. During the almond butter treatment, participants will consume 2 tbsp of almond butter per day as an evening snack. The control treatments will be a no-snack control. Fasting blood glucose, as well as glucose trends, will be measured using Continuous Glucose Monitor (CGM). Participants will also be asked to take simple cognitive tests on a study-provided smartphone each day of the study and report their daily food intake and physical activity.

Eligibility Criteria:
Inclusion Criteria:

* Individuals with diagnosed type 2 diabetes
* Not on insulin therapy
* On stable does of oral antihyperglycemic agent (no dose change for 6 months)
* Currently monitoring blood glucose at home via glucometer
* Willing and able to adhere to study protocol

Exclusion Criteria:

* Individuals with type 1 diabetes, cardiovascular disease, kidney disease, liver disease, cancer or inflammatory conditions (e.g. GI disorders, rheumatoid arthritis)
* Women who are pregnant, breastfeeding, or have been pregnant within the last 6 months or breastfeeding within the last 6 weeks
* Individuals who smoke or use tobacco products
* Use of insulin therapy or sulfonylurea medications
* Allergy to any tree nut
* Liver or kidney disease
* Allergy to Dexcom CGM adhesive
Serum Proteomic Profiling for the Early Diagnosis of Colorectal Cancer

No ideal serum biomarker currently exists for the early diagnosis of colorectal cancer (CRC). Therefore, it is urgent that accurate and reliable serum biomarkers be identified.

Magnetic bead-based fractionation coupled with matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) was used to screen serum samples from CRC patients and healthy controls.

Eligibility Criteria:
Patients with colorectal cancer

Inclusion criteria

* histologically confirmed colorectal cancer
* aged 18 years or older
* have provided written informed consent

Exclusion criteria

* refusal to participate

Healthy controls

Inclusion criteria

* no cancer history
* aged 18 years or older
* have provided written informed consent

Exclusion criteria

* refusal to participate
* have first-degree relative with a known history of colorectal cancer