cyrilzakka/clinical-trials huggingface dataset:
Application of Artificial Intelligence on the Diagnosis of Helicobacter Pylori Infection and Premalignant Gastric Lesion

The aim of this diagnostic accuracy study is to evaluate the application of artificial intelligence on the diagnosis of Helicobacter pylori infection and premalignant gastric lesions based on upper endoscopic images. We use techniques of artificial intelligence to analyze the correlation between endoscopic images and urea breath test results/histopathological results.

This study had invited patients to undergo urea breath test, upper gastrointestinal endoscopy, and histology examination. The study will collect their tests results, upper gastrointestinal endoscopy images, and histopathological results. Artificial intelligence techniques will be used to analyze the correlation between endoscopic images and urea breath test results/histopathological results. We aim to establish a telemedicine system to assist clinicians in diagnosing Helicobacter pylori infection and detecting premalignant gastric lesion using upper endoscopic images. The system will be implemented as a telemedicine service system in the rural areas, for example Matsu Islands. The baseline histological predictions will be linked to the newly incident gastric cancer.

Eligibility Criteria:
Inclusion Criteria:

1. Age 20-80
2. Scheduled urea breath test and endoscopy

Exclusion Criteria:

1. History of gastric surgery
Evaluation of Novel Biomarkers to Improve Risk Stratification and Patient Selection in Implantable Cardioverter-defibrillator (ICD) Therapy

Implantable cardioverter-defibrillator (ICD) therapy reduces mortality in patients with chronic heart failure and reduced left ventricular ejection fraction (LVEF) \<36%. Nevertheless, patient selection for ICD therapy based on LVEF and NYHA functional class alone seems to have a low specificity and sensitivity: In 100 patients treated, the SCD-HeFT study prevented 7 deaths in 5 years. Therefore 93 patients have a risk of adverse effects, such as operation risk, infection, pneumothorax, lead dislocation, and inadequate icd therapy. On the other hand, patients with advanced or end stage heart failure might rather die off progressive heart failure death and thus not benefit from ICD therapy.

It therefore seems appropriate and necessary to improve the individualized risk stratification in these patients. The aim of this study is to evaluate multiple cardiac biomarkers in a model predicting ventricular arrhythmias in patients on ICD therapy.

Patients having or getting an ICD in the Dept. of Cardiovascular Medicine of the Hannover Medical School will be recruited in the next 2 years. Blood samples of all patients will be obtained at inclusion and at 6 months follow-up. Patients will be followed-up for 1-2 years after inclusion.

Eligibility Criteria:
Inclusion Criteria:

* Patient meeting the current indications for primary or secondary prophylactic ICD/CRT-D therapy
* age 18 years or older

Exclusion Criteria:

* Patient unwilling to participate.
The Utility of Virtual Reality in the Management of Pediatric Functional Constipation With Pelvic Floor Dysfunction.

1. To determine if the adjunctive use of a Virtual Reality (VR) module on diaphragmatic breathing (DB) can improve the quality of life (QOL) and symptoms of children with functional constipation (FC) with pelvic floor dysfunction (PFD) who are receiving standard of care treatment.
2. To assess if a VR module on DB can decrease healthcare utilization for children with FC with PFD.

The investigators will assess if the use a Virtual Reality (VR) module on diaphragmatic breathing (DB) can improve quality of life, constipation symptoms, and decrease healthcare utilization for children with functional constipation (FC) with pelvic floor dysfunction (PFD). FC is a common pediatric condition with a high prevalence and $4.25 billion yearly in healthcare expenditures. FC is often complicated with PFD as seen through stool withholding behaviors. Children with FC with PFD are referred to occupational therapy for biofeedback and DB training as standard of care. Occupational therapy uses to teach children with FC with PFD to relax their abdominal muscles, and subsequently their pelvic floor muscles, facilitating a more complete bowel evacuation. VR is a technology currently employed in rehabilitation services, anesthesiology and surgery. VR can provide a fun, immersive environment with a feedback component for children with FC to learn DB effectively and build a positive association with toileting.

The purpose of this study is to examine if a virtual reality module that teaches children diaphragmatic breathing through an immersive game can improve the quality of life and decrease health care utilization for children with functional constipation and pelvic floor dysfunction.

Eligibility Criteria:
Inclusion Criteria:

* Ages 7 to 21 years old
* Meets Rome IV criteria for functional constipation and pelvic floor dysfunction
* Developmentally appropriate to understand verbal instructions

Exclusion Criteria:

* Co-existing medical conditions that include inflammatory bowel disease, Hirschsprung's Disease, cystic fibrosis, tethered cord, anal stenosis, sacral agenesis, spinal cord anomalies, untreated thyroid disease, untreated celiac disease, neurogenic bowel, cerebral palsy, major bowel surgery.
* Non-English speaking
Use of Lexiscan for Myocardial Stress Perfusion Computed Tomography With a 3rd Generation Dual Source CT System

The purpose of this study is to evaluate the feasibility, tolerability, safety, and image quality of low-radiation, dynamic perfusion CT of the heart in patients with suspected ischemic chest pain and a moderate or severe stenosis seen on coronary CTA. Secondary aims include the assessment of the diagnostic accuracy of CT perfusion imaging compared to either SPECT or invasive angiography.


Eligibility Criteria:
Inclusion Criteria:

1. Subject must present with symptoms (e.g. chest pain) suspicious for cardiac ischemia as determined by treating physician.
2. Subject must have been referred for cardiac CT angiography OR subject must have undergone clinically indicated SPECT with positive or equivocal findings OR subject must have undergone clinically indicated SPECT with prior cardiac CT angiography that showed moderate or severe stenosis.
3. Subject must be 18 - 85 years of age.
4. Subject must provide written informed consent prior to any study-related procedures being performed.
5. Subject must be willing to comply with all clinical study procedures.

Exclusion Criteria:

1. Subject is a pregnant or nursing female. Exclude the possibility of pregnancy:

   * By testing (serum or urine beta HCG) within 24 hours before study agent administration, or
   * By surgical sterilization, or
   * Post menopausal, with minimum one (1) year history without menses.
2. Subject has severe asthma or COPD requiring frequent inhaler use.
3. Subject has prior diagnosis of obstructive CAD that has not been revascularized.
4. Subject with implanted rhythm devices (pacemaker, defibrillator).
5. Subject has significant arrhythmia.
6. Subject has high grade heart block.
7. Subject has resting heart rate \< 45 bpm, systolic blood pressure \<90 mm Hg, or has consumed caffeine within the last 12 hours.
8. Subject has an acute psychiatric disorder.
9. Subject is unwilling to comply with the requirements of the protocol.
10. Subject has previously entered this study.
11. Subject has an allergy against iodinated contrast agents or pharmaceutical stressors used in this study.
12. Subject suffers from claustrophobia.
13. Subject has impaired renal function (creatinine \> 1.5 mg/dl).
14. Subject is in unstable condition.
15. ST-elevations, new transient ST changes greater than 0.05mV or T- wave inversions with symptoms
16. Subject cannot safely be administered Lexiscan™ per prescribing information as determined by investigator
17. Subject has received interventional (PCI, stenting) or surgical (CABG) treatment that may alter the cardiac condition regarding myocardial perfusion status and/or stenosis degree between cardiac CTA, SPECT, and/or CT stress perfusion studies.
Safety and Effectiveness of Left Atrial Appendage Occlusion

This study is to evaluate acute and long-term safety and effectiveness of Left atrial appendage occlusion (LAA)with the AtriCure LAA Occlusion System. This device will be applied in patients with atrial fibrillation (AF), paroxysmal, persistent and permanent, undergoing cardiac surgery with a concomitant Maze/Ablation procedure.


Eligibility Criteria:
Inclusion Criteria:

1. Documented history (paroxysmal, persistent or permanent) of AF \[one episode within the last 12 months of enrollment\]
2. Elective Maze procedure
3. Suitable anatomy
4. Able and willing to sign informed consent
5. Age over 18 years

Exclusion Criteria:

1. Patient from Intensive Care Unit with either:

   1. intra-venous catecholamines
   2. ventilator
   3. cardiac index \<1.8 l/min.
2. Reoperative Cardiac Surgery
3. Systemic or Inflammatory disease
4. Dialysis
5. Recent myocardial infarction (\< 21 days)
6. History of pericarditis
7. Patient taking part in any other device or drug study
8. Patient with known sensitivity or allergy to any of the device components
9. Pregnancy
Enhanced Coordinated Specialty Care for Early Psychosis

The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis. The main question it aims to answer is:

• Does the addition of certain elements of care increase the number of visits in treatment for first-episode psychosis?

Participants will either:

* Receive care as usual (CSC) or
* Receive care as usual (CSC) plus five additional care elements (CSC 2.0):

  1. Individual peer support
  2. Digital outreach
  3. Care coordination
  4. Multi-family group therapy
  5. Cognitive remediation

Researchers will compare the standard of care (CSC) to CSC 2.0 to see if participants receiving CSC 2.0 have more visits to their clinic in their first year.


Eligibility Criteria:
Inclusion Criteria:

* People undergoing an intake evaluation to CSC for first-episode psychosis in one of the following outpatient clinics:
* McLean Hospital OnTrack (OnTrack Clinic)
* Massachusetts General Hospital (FEPP Clinic)
* Boston Medical Center (WRAP Clinic)
* Cambridge Health Alliance (RISE Clinic)
* UMass Memorial Health Care (STEP Clinic)
* ServiceNet (PREP West)

Exclusion Criteria:

* None
The Effect of the Kinesio Tape on the Muscle Power Performance of Elite Weightlifters

This study is aimed to investigate the effect of the Kinesio Tape facilitation technique on the muscle power performance of elite weightlifters.

Most sportsmen require the power of muscles for their performance. Weightlifting exercises such as the snatch or clean and jerk and their variations are frequently included in the power training programs of athletes who contest or participate in sports that need muscle power. The weightlifting exercises require athletes to accelerate the weight throughout the whole second pull phase, causing the barbell to be raised overhead and the athlete's body into the air, a movement in which the feet leave the platform. Furthermore, the movement patterns of the weightlifting exercises are mostly considered to be similar to athletic movements in different sports such as jumping and sprinting in soccer and basketball. Empirically, the kinetic qualities of the second pull phase are similar in both weightlifting and jumping movements. The role of the sport physical therapist is not restricted only to rehabilitation and injuries prevention, but they can also contribute to the performance of the athletes in a different aspect. Therefore, finding tools which may improve the muscle power of the weightlifters could increase the success in performing the sport-specific movements with higher loads. This could make the difference between winning or losing a competition. Thus, if it could be proven that the Kinesio Tape has the capability to improve muscle power, it could be used as a tool by the physiotherapist, either for enhancing the athlete's performance or for accelerating the last stage of the rehabilitation and, therefore, decreasing the number of absent days of athletes from training or matches due to injury.

Eligibility Criteria:
Inclusion Criteria:

* 46 Male weightlifters from 18-35 years old.
* Weightlifters who playing at national weightlifting level.

Exclusion Criteria:

* Musculoskeletal injuries or surgery that may affect performance in the last 6 weeks prior to the study as reported by participant.
* Any neurological problem that may affect performance as reported by the participant.
* Known adverse reactions to taping.
* Any systemic diseases that affect the performance as reported by participant.
Interpersonal Psychotherapy for Depressed Adolescents Engaging in Non-suicidal Self-injury

The purpose of this study is to examine the feasibility of using Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) to treat adolescents who are experiencing symptoms of depression and are engaging in non-suicidal self-injurious behaviors. The trial will include recruiting 10 particpants, administering 12-sessions of individual IPT-A, and determining how the IPT-A protocol needs to be amended to adequately address the self-injury in addition to depression.

Engagement in non-suicidal self-injury (NSSI), purposefully harming oneself without the conscious intent to die such as cutting or burning, is pervasive among adolescents. Lifetime prevalence estimates among community samples of high school students range from 13.0% to 23.2%. Despite the significance of this public health problem, there are no known interventions that successfully reduce the frequency of NSSI or prevent NSSI in adolescents. The goal of the current study is to develop an effective psychosocial intervention for NSSI among adolescents who are engaging in self-injury and have a depressive disorder. Specifically, we will amend Interpersonal Psychotherapy for Depressed Adolescents (IPT-A), a psychotherapy that has demonstrated efficacy in treating depressed adolescents (Mufson et al., 1994, 1999, 2004), for use with adolescents with depression who are engaging in NSSI, with the ultimate goal of curing the depression and NSSI. Ten participants will be administered IPT-A and assessed several times throughout the course of the trial. It is expected that IPT-A will be a useful treatment for co-morbid depression and self-injury, although adaptations to the protocol will likely be needed to address the behavioral aspect of the self-injury. Data analyses will be descriptive in nature and involve examining the individual trajectories of depression and NSSI over time. The data obtained from the current study will lay the groundwork for an ultimate randomized controlled trial in which we plan to compare IPT-A versus nondirective supportive therapy in the treatment of co-morbid depression and NSSI.

Eligibility Criteria:
Inclusion Criteria:

1. 12 to 18 years of age
2. Diagnosis of MDD, Dysthymic Disorder, Depressive Disorder NOS, Adjustment Disorder with depressed Mood
3. Non-suicidal self-injurious behavior
4. CDRS \>= 36
5. C-GAS \<= 65
6. English speaking patient
7. One English speaking caregiver -

Exclusion Criteria:

1. Suicide attempt within past 6 months or actively suicidal
2. Severe incident of non-suicidal self-injury in past 3 months
3. Severe episode of MDD
4. Treatment resistant non-suicidal self-injury
5. Frequent non-suicidal self-injury
6. Mentally retarded
7. Current diagnosis of: PTSD, OCD, Schizophrenia, Bipolar Disorder, Psychosis, Substance Dependence, ADHD
8. Current substance use
9. Currently in active treatment for same condition
10. Currently taking antidepressant medication
11. Medical illness likely to interfere with treatment -
Fecal Microbiota Transplantation As a Potential Treatment for Parkinson's Disease

this pilot study aims to further explore the potential usage of Fecal microbiota transplantation in treating constipation and possibly also motor symptoms in Parkinson's disease (PD) patients, and to increase understanding of the potential relationship between the identities of intestinal microbial communities and PD.

Fecal microbiota transplantation (FMT) is a technique in which intestinal microbiota are transferred from a healthy donor to the patient, with as primary goal to introduce - or restore - a stable and 'healthy' microbial community in the gut.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms and Gastrointestinal dysfunction, in particular constipation, affects up to 80% of PD patients and may precede the onset of motor symptoms by years.

this study include one group of PD patients that will receive FMT. two other groups will serve as controls:

1. PD patients that will not receive FMT
2. healthy people who live with PD patients in the same house and share similar surrounding

Eligibility Criteria:
Inclusion Criteria:

* Subjects aged \> 50 years, diagnosed as suffering from PD and under follow up of the Movement Disorders Clinic in Soroka University Medical Center.
* Subjects complaining of constipation .
* Subjects who did not perform a screening colonoscopy for colon cancer.
* Subjects who are clinically undertreated according to last Movement Disorders specialist's impression at the clinic visit.

Exclusion Criteria:

* Subjects who do not complain of constipation or seem clinically stable properly treated pharmacologically.
* Subjects who already underwent a screening colonoscopy for colon cancer.
* Subjects who suffer from a cognitive decline and could not give their consent, or patients who refuse to undergo a colonoscopy.
A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal

The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.

Despite the frequent use of benzodiazepines for the treatment of alcohol withdrawal, studies comparing the efficacy of long and short half-life benzodiazepines in the treatment of alcohol withdrawal have shown mixed results. Due to the conflicting nature of published reports, clinicians have no clear indication as to which type of agent is preferable. The purpose of this study is to compare the efficacy of two commonly accepted medications in the treatment of alcohol withdrawal, diazepam and lorazepam, which are long and short half-life benzodiazepines, respectively.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of alcohol withdrawal
* History of alcohol use within 24 hours
* Ability to consent to participate in the study

Exclusion Criteria:

* Unwillingness to participate in the study
* Active abuse of other CNS depressants
* Acute intoxication with a CNS activating agent
* Severe hepatic dysfunction
* Pregnancy
* History of dementia
Efficacy and Safety Study of an Oral Contraceptive in Healthy Females

The purpose of this study is to determine whether the study drug is safe and effective in the prevention of pregnancies in a large group of volunteers.

This study has previously been posted by Berlex, Inc. Berlex, Inc. has been renamed to Bayer HealthCare Pharmaceuticals Inc.. Bayer HealthCare Pharmaceuticals Inc. is the sponsor of the trial.

Eligibility Criteria:
Inclusion Criteria:

* Healthy women between the ages of 18 and 35 years requiring contraception

Exclusion Criteria:

* Pregnancy, lactation, and contraindication of combined oral contraceptive
Verbal Instruction for Contraction Pelvic Floor Muscles Among Males

The aim of this study is to compare the effectiveness of different verbal instruction on pelvic floor muscle contraction among males. Pelvic floor contraction will be measured via ultrasound.

This study will examine pelvic floor muscle contraction following six different verbal instructions among males. Physical-therapy students will be recruited to complete a survey and non-invasive transabdominal ultrasound assessment.

A bladder filling protocol will be implemented to ensure subjects will have sufficient fluid in their bladders to allow clear ultrasound imaging. This protocol involved subjects consuming 600-750 ml of water in a 1 hr. period. The participants will be tested in a crook-lying supine position with a pillow under their heads for comfort.

All participants will be given six different verbal instructions to contract pelvic floor muscles. Each contraction will be performed 3 time with rests of 10 sec between contractions. While the first 2 contractions for each verbal instruction will be held for 3 sec. the last contraction will be held as long as the participant can conduct and the time of contraction will be measured as well. The pelvic floor contraction will be measured by assessing bladder displacement via diagnostic ultrasound.

To image the pelvic floor a 5 MHz curved linear array transducer (Mindray M5) will be placed in the transverse plane immediately suprapubically over the lower abdomen angled at 15-30 degrees from the vertical. An on screen caliper and measurement tool will be used to measure bladder displacement.

Eligibility Criteria:
Inclusion Criteria:

* willing to participate in the study

Exclusion Criteria:

* none
Study of Gut Microbiota in Crohn's Disease Patients Suffering From Spondylarthritis

The FLORACROHN project aims to compare gut microbiota of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA).

3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA.

Fecal microbiota will be determined by 16SRNA gene sequencing.


Eligibility Criteria:
Inclusion Criteria:

* Patients with Crohn's disease and axial spondyloarthritis according to the criteria below.

  * Patients with Crohn's disease (CT patients) diagnosed according to clinical, biological, radiological, endoscopic and / or histological criteria for 3 months. With diagnosis of spondyloarthritis exclusion on modified ASAS and / or New York criteria.
  * Patients with axial spondyloarthritis (SpA patients) diagnosed according to the modified ASAS and / or New York criteria with exclusion diagnosis of Crohn's disease.
* Patient with the capacity to give free and informed consent.

Exclusion Criteria:

Antecedent of colonic resection

* Antibiotic or colonic colonoscopy preparation in the 8 weeks prior to stool collection (against temporary indication = collection possible before colic preparation or on the first saddle after the start of the colic preparation).
* Ostomy at time of collection
* BMI\> 30
* extreme diet
* unbalanced diabetes
* Patient under guardianship, under curatorship or under safeguard of justice