cyrilzakka/clinical-trials huggingface dataset:
Measurement of Greenhouse Gas Emissions From Meals of a University Food Operator

Université Laval wishes to raise awareness among students and employees in the university community so that they become aware of the impacts of their consumption choices by equipping them to adopt consumption behaviours that are favourable to the environment and their health. To do this, it is necessary to assess consumers' perception of the information available when choosing a meal to determine, among other things, whether knowledge of greenhouse gas (GHG) emissions influences their selections. In addition to this evaluation criterion, consumer perception of the nutritional quality of food will also be assessed. The nutritional composition of the meals of the characterized week will make it possible to calculate, using a nutritional profiling tool, the nutritional quality score of each meal of the day.

This study consists of an individual meeting with each participant. This meeting will last approximately 1 hour during which each subject will choose a meal and complete various questionnaires. Subjects (male or female) will be randomly assigned to one of the four experimental conditions ("GHG", "nutrition", "GHG+nutrition" and "no logo"). Since subjects could change their eating behaviours if they knew the true purpose of the study, they will be deliberately misled when they enter the study. Participants will be recruited to participate in a market research study in which they will be invited to taste and evaluate a new meal for the cafeteria. At the end of the session, each participant will be informed of the actual objective of the study.

In this context, the general objectives of this second phase of the project are therefore:

1. Evaluate consumer perceptions of the available information on the GHG score (in equivalent C02), the nutritional quality score and the eco-efficiency score (combination of GHG + nutrition), and;
2. Determine if the presence of information (logo on the different scores) influences food choice and consumption among Université Laval students and staff.

Eligibility Criteria:
Inclusion Criteria:

* Study or work at Université Laval

Exclusion Criteria:

* People taking drugs that may affect appetite (e.g., antidepressants, antipsychotics or corticosteroids);
* People with food allergies or intolerances, and pregnant and lactating women;
* People with food aversions to more than 20% of the main meal ingredients from the menu.
Phase 2 Study of XAF5 (XOPH5) Ointment for Reduction of Excess Eyelid Fat (Steatoblepharon)

This study will test whether XAF5 (XOPH5) ointment, applied once daily to the lower eyelids for 10 weeks, reduces the prominence of lower eyelid fat in adults with moderate to severe steatoblepharon (excess eyelid fat).


Eligibility Criteria:
Inclusion Criteria (abbreviated):

* Moderate to severe lower eyelid steatoblepharon (LESS score of 2-4 bilaterally)
* Men and women 40-70 years old
* Healthy facial skin
* Must understand and provide informed consent

Exclusion Criteria (abbreviated):

* Best corrected visual acuity worse than 20/40 in either eye
* Regular use of ophthalmic medication in either eye
* Planned use of contact lenses during the study
* Any history of lower eyelid surgery
Maximizing Energy After Traumatic Brain Injury

Traumatic brain injury (TBI) is the signature injury of the wars in Iraq and Afghanistan. Up to 73% of TBI patients endorse fatigue as their most challenging symptom.

Fatigue leads to decreased participation in everyday life and return to work. The Maximizing Energy (MAX) intervention trains individuals with TBI to manage their fatigue.

The intervention individualizes the Occupational Therapist delivered Energy Conservation Strategies education by using the framework of Problem Solving Therapy. The purpose of this single-blind randomized clinical trial was to test the effect of the Maximizing Energy (MAX) intervention for decreasing the impact and severity of post-TBI fatigue, increasing participation in everyday life and physical activity, and decreasing work disability.

A significant proportion (50-80%) of individuals with traumatic brain injury (TBI) experience persistent fatigue and endorse it as the most distressing and challenging symptom that affects daily life. Chronic fatigue has a devastating impact on individuals because it leads to reduced participation in everyday life. Despite the high incidence of post-TBI fatigue and its impact on everyday life, these is a dearth of studies examining the effectiveness of non-pharmacological interventions for the treatment of post-TBI fatigue. This study is unique in that it will examine the effectiveness of a non-pharmacological intervention to manage post-TBI fatigue. The Maximizing Energy (MAX) Intervention, individuals with post-TBI fatigue will reduce the impact of fatigue on everyday life by actively seeking and implementing solutions for their fatigue-related problems, thus promoting their reintegration into the community.

Eligibility Criteria:
Inclusion Criteria:

1. Age: 18 years or older
2. Patient lives within a 50 miles radius of the University of Pittsburgh in Oakland
3. Diagnosis of TBI atleast 6 months ago: Individuals need time to determine if they have chronic fatigue after CA.
4. Community dwelling: Community dwelling participants are more likely to be able to make environmental changes than those in institutions
5. Vision to operate a computer:
6. Presence of fatigue: Fatigue Severity Scale is a valid and reliable test used to measure the severity of fatigue on 9 fatigue-related statements on a 7 point ordinal scale. A score ≥ 4 signifies fatigue severe enough to limit daily activities.
7. No cognitive impairment
8. Functional English fluency and literacy

Exclusion Criteria:

1. Physical impairment: Individuals scoring \< 65 on the 13 Functional Independence Measure (FIM) motor items will be excluded from the study;
2. Mood and mental health history: Individuals with a recent (less than 3 months) history of major depressive disorder, mania, hypomania, psychosis, or substance abuse as diagnosed by the PRIME-MD and the MiniInternational Neuropsychiatric Interview (MINI) unless treated or in partial remission will be excluded because their self-reports of participation in everyday life may not be reliable; and
3. Disability due to other diagnoses: history of neurologic, traumatic, or psychiatric conditions.
Nasal Allergen Challenge - Reproducibility of Biomarkers and Effect of Topical Steroid Treatment

Subjects with allergic asthma developing the required nasal symptoms in response to nasal allergen titration during a screening period will be randomized 1:1 to one of 2 cohorts. All subjects will have repeated nasal challenges with allergen. One cohort will have nasal saline challenge as control. One cohort will have intranasal corticosteroid intervention.

Eligible subjects will be randomized 1:1 to Cohort A or Cohort B. Each cohort will undergo 3 nasal challenges, each separated by 3 weeks. Cohort A will undergo 2 nasal allergen challenges, and 1 nasal diluent challenge. TNSS, PNIF, spirometry, and samples of blood, urine and nasal secretions will be collected until 24h post-challenge to assess reproducibility. Cohort B will undergo 3 nasal allergen challenges; one of the challenge will be conducted after 14 days treatment with placebo, and one challenge will be conducted after 14 days treatment with triamcinolone acetonide aqueous nasal spray at a dose of 220 mcg administered twice daily for a total daily dose of 440 mcg. TNSS, PNIF, spirometry, and samples of blood, urine, nasal secretions will be collected until 24h post-challenge to determine reproducibility, and nasal tissue will be collected 24h post-challenge to determine effect of steroid treatment.

Eligibility Criteria:
Inclusion Criteria:

* allergic rhinitis + mild asthma

Exclusion Criteria:

* other respiratory disease
* any medication for treatment of asthma/allergic rhinitis with the exception of infrequent beta-2 agonist.
Optimal Timing of Percutaneous Intervention in Non-maturing Dialysis Fistulas

Arteriovenous fistulas (AVFs) are the preferred type of vascular access for dialysis, but many of them fail to mature. The optimal timing of intervention to salvage immature AVFs is unknown.The study proposes a randomized clinical trial comparing the clinical and economic impact of early vs late angioplasty in non-maturing AVFs.

The study proposes a RCT to test the hypothesis that, as compared to early angioplasty of non-maturing AVFs, late angioplasty results in a lower proportion of AVFs being used at 6 months, but a greater long-term AVF patency , lower requirement of subsequent interventions to maintain AVF patency for dialysis, and lower overall cost of access maintenance.

The optimal timing of intervention in non-maturing AVFs remains controversial, and can only be definitively addressed by a randomized clinical trial (RCT) comparing early (6 weeks) vs late (3 months) angioplasty of non-maturing AVFs. The investigators will perform a single-center, prospective RCT. The investigators will recruit 112 patients who initiated hemodialysis with a CVC, then had a new AVF created after commencing dialysis, and then had a 6-week postoperative ultrasound that revealed an immature AVF (diameter \< 4 mm diameter or blood flow \< 500 ml/min). These patients will be randomized to one of two groups: an early intervention group that will undergo a routine PTA at 6 weeks after AVF creation, or a late intervention group in which early PTA will be avoided and subsequently be performed only if the 3-month ultrasound indicates persistent AVF immaturity. These patients will be followed for 2 years.

Eligibility Criteria:
Inclusion Criteria:

* Patients with End stage renal disease (ESRD).
* Patients on hemodialysis.
* Patients using central venous catheter (CVC).
* Patients who had a new AVF created after commencing dialysis.
* Patients who had immature fistula ( 6-week postoperative ultrasound that revealed an immature AVF (diameter \< 4 mm diameter or blood flow \< 500 ml/min).

Exclusion Criteria:

• Children with Age below 18
The Effect of Child Position on the Results of Hyperventilation During Routine Electroencephalography

Electroencephalograhy (EEG) is used as a tool for diagnosing epilepsy/convulsions.

During the recording, especially for childen who are suspected of having abbcence epilepsy the investigators will perform an EEG recording including a provocation test of hyperventilation in order to induce epileptic discharges.

There is no clear instruction about the position of the child during performing this hyperventilation provocation.

Clinical observations showed that this provocation is more effective when it's performed in the siiting position.

No study was previously performed to investigate this issue

The study will include 30 patients at the age of 4-10 years old of both sexes. after signing an informed concent, every child, suspected of having absence seizures, will undergoe an EEG recording including a provocation of hyperventilation.

The study will include two groups:

1. A group of 15 children who will undergoe an EEG recording with 3 minutes of hyperventilation in the prone position, followed by 5 minutes of rest, then after another 5-10 minutes of recording with normal breathing. Finally the participants will performed additional 3 minutes of hyperventilation in the sitting position
2. A group of 15 children who will undergoe an EEG recording with 3 minutes of hyperventilation in the sitting position, followed by 5 minutes of rest, then after another 5-10 minutes of recording with normal breathing. . Finally the participants will performed additional 3 minutes of hyperventilation in the prone position.

Participants who will not be able to perform all the steps of the study will be excluded The analysis of the study results will be performed by a specialist in pediatric neurology and pediatric epilepsy who will confirm whether the EEG recording show epileptic discharge (sharp waves, slow waves, combination of sharp and slow waves, spikes or combination of spikes and slow waves)

Eligibility Criteria:
Inclusion Criteria:

* children suspected of having absence seizures in the ages mentioned above.
* legal guardian approval

Exclusion Criteria:

* inability to perform hyperventilation
* children who have absence seizure under anti-convulsive treatment
Combined Application of Remote and Intra-Coronary Ischemic Conditioning in Acute Myocardial Infarction

Infarct size is a major determinant of prognosis after AMI. Evidence indicates that the combination of intracoronary ischemic conditioning (ICIC) and remote ischemic conditioning (RIC) can significantly reduce infarct size in STEMI patients. Whether the combination of these two interventions may improve clinical outcome after STEMI remains unknown. The objective of the present study is to determine whether combination of ICIC and RIC can improve STEMI patients clinical outcome at 6 months.


Eligibility Criteria:
Inclusion Criteria:

* All (male and female) patients, aged over 18,
* Presenting within 12 hours of the onset of chest pain,
* For whom the clinical decision was made to treat with percutaneous coronary intervention (PCI),
* ST segment elevation ≥ 0.2 mV in two contiguous ECG leads,
* Written informed consent obtained or oral informed consent certified by a third party.

Non inclusion Criteria:

* Patients with cardiogenic shock,
* Patients with uncontrolled (treated or untreated) hypertension (\> 180/110 mmHg),
* Patients with loss of consciousness or confused,
* Patients without health coverage,
* Patient with any legal protection measure,
* Female patients currently pregnant (oral diagnosis) or women of childbearing age who were not using contraception.

Exclusion Criteria:

Patients with main occlusion localized on :

* LAD: distal or ostial segment,
* Non dominant RCA / CX: mid or distal segment,
* Dominant RCA / CX: distal segment,
* Any other arteries apart LAD/CX/RCA; Patients with evidence of coronary collaterals to the risk region (Rentrop score ≥ 2); Patients with an opened (TIMI \> 1) culprit coronary artery on initial admission coronary angiography or a failed PCI (final TIMI=0).
Patient Controlled Remifentanil Analgesia for Normal Labour

Patient controlled remifentanil analgesia might offer comparative overall patient satisfaction and improved quality of analgesia after normal labour with continuous epidural analgesia.

We are aiming to study the effects of patient controlled remifentanil analgesia and epidural analgesia for normal labour in full term parturients on:

* Peripartum analgesia
* Overall patient's satisfaction
* Maternal adverse effects
* Neonatal outcomes

Eligibility Criteria:
Inclusion Criteria:

* Gestational age \> 36 weeks
* American Society of Anesthesiologists physical class I to III

Exclusion Criteria:

* Allergy to study solution
* Contraindications to epidural analgesia
* Non consented parturients
* Communications barriers.
* Intrauterine foetal growth retardation
* Foetal distress
Nutritional Evaluation of Patients With Congestive Heart Failure

This study objective is to assess the nutritional status of Patients With Congestive Heart Failure.


Eligibility Criteria:
Inclusion Criteria:

* Congestive heart failure patients between tne ages 40 to 90,all stages of the disease.

Exclusion Criteria:

* non
Evaluation of a Mind-body Education Program to Enhance Resiliency and Reduce Burnout in Residents

This prospective, waitlist-control study is evaluating the benefits of a stress management and resiliency training program for residents (SMART-R).

The primary aim of this study is to determine whether the SMART-R is effective at increasing coping skills and reducing stress among residents, reflected by changes in constructs such as emotional growth, perceived stress, optimism, and coping styles. Objective parameters (heart rate, galvanized skin response, sleep duration and quality, exercise and actigraphy) measured with the Basis health tracking device will help correlate objective signs to subjective report of stress.

The investigators adapted the Benson-Henry Institute Stress Management and Resiliency Training Program -- Relaxation Response Resiliency Program (SMART-3RP) to create the SMART-R resident wellness curriculum. The actual SMART-3RP is both a clinical program and research intervention. The three prongs of the SMART-R include 1) elicitation of the relaxation response through mind-body techniques 2) reducing overall stress reactivity and 3) increasing connectedness to self and others.

In a waitlist-control design, the SMART-R was implemented into multiple residents programs at Mass General Hospital, NYU Langone Medical Center, and Weill Cornell Medical College. The primary aim is to evaluate the effectiveness of the SMART-R in increasing coping skills and reducing stress among residents in the participating programs. Participants enrolled will be invited to complete 1) a brief questionnaire before, during (q3months) and after participation in the program (5 questionnaires total). The investigators will also collect continuous physiologic data using the Basis Peak Health Tracking device to correlate the physiologic data with self-report measures of stress.

Additionally, objective indicators of daily workload (page frequency, and quantity of notes authored by a resident during a given period) will help control for residents' schedules and busyness, in evaluating perceived stress, wellbeing and other outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Residents in the following participating departments: departments of psychiatry, pediatrics, or neurology at MGH, medicine or psychiatry at NYU, or medicine or psychiatry at Cornell

Exclusion Criteria:

* Not a resident in the participating departments
Efficacy and Safety ofCACXL in the Treatment of Keratoconus With Thin Corneas

The aim of this study is to detect the safety and effectiveness of contact lens assisted corneal cross linking in managing progressive keratoconus with thin corneas CACXL was done for 40 eyes of 30 of keratoconic patients presented to cornea outpatient clinic in Kasr Alainy teaching hospital The UDVA ,BDVA KMAX, thinnest corneal thickness pre-operative and 9 months postoperatively and the endothelial cell count was measured preoperative and 3 months postoperative Demarcation line was measured after 1 month by using ASOCT There was statistical significant difference in UDVA and BDVA, there was stabilization of Kmax there was decrease in endothelial cell count but not statistically significant According to results the procedure seems to be effective and safe un managing progressive keratoconus.

Corneal collagen cross linking showed effective results in stabilizing progressive keratoconic corneas. It is the only treatment that halts progression of keratoconus, It was first described in 1998 by Spoerl et al . A major limitation of the procedure that it cannot be used in corneas with pachymetry less than400 micrometers based on the fact that an irradiance of 0.37 mW/cm2 has been found to be cytotoxic for the endothelial cell layer. Since the absorption coefficient for the human corneas is 70 cm-1 and the intended surface irradiance is 3.0 mW/cm2, the 0.37 mW/cm2 irradiance is reached at 300 microns depth. In a 400 microns thick cornea saturated with riboflavin, the irradiance at the endothelial level is 0.18 mW/cm2, which is a factor of 2 smaller than the damage threshold. Therefore, the 400 microns limit is considered to be a safe limit to protect the endothelium and intraocular structures from the hazards of UV irradiation 12 However , the patients with advanced ectasia who are desperately in need for cxl , are the same ones who have thin corneas often below the threshold which is considered to be safe for CXL treatment However further studies with longer follow up and larger numbers of cases are needed to confirm our findings.

Eligibility Criteria:
Inclusion Criteria:

* Age from 18 to 35years old Mild , moderate and severe keratoconic patients with a corneal thickness from 360-400 µm at the thinnest location .

Exclusion Criteria:

* • Previous corneal surgeries such as rings or crosslinking.

  * Patients with stromal corneal scar.
  * Other ocular pathology such as glaucoma or iridocyclitis.
  * Patient with systemic diseases that likely affects wound healing such as insulin dependent diabetes mellitus.
  * Patients with collagen vascular diseases, autoimmune or immune deficiency diseases.
  * Pregnant or nursing women.
  * Patients taking the following medications ; isotretinoin, amiodarone, sumatriptan.
  * Other corneal pathology rather than keratoconus
Comparison of the Effectiveness of Two Different Squat Exercises in Healthy Individuals

The aim of our study is to compare the effects of two different squatting patterns, with and without the knees passing the toes, on low back pain, muscle strength and balance.

A total of 60 volunteer participants between the ages of 18-30, who are in the active category of the International Physical Activity Assessment Questionnaire Short Form, are planned to be included in the study. Individuals participating in the study will be divided into 3 groups using a computer randomization system and a closed envelope method. Group I (n=20); squatting with the knees passing the toes (PI), Group II (n=20); squatting with the knees not passing the toes (PG) and Group III (n=20); control group (CG). Squatting with the knees passing the toes (PI); squatting with the knees not passing the toes (PG) will be applied to the study groups as a home program for 4 weeks and will be checked with an exercise diary. Participants will be re-evaluated at the end of the exercise program. No training program will be applied to the control group and they will be asked to continue their daily lives and participants will be evaluated at 4-week intervals. The training program of 1 set; 20 repetitions; 30 seconds active contraction/30 seconds rest is applied to the PI and PG groups 3 days a week, every other day for 6 weeks. The training program of the groups is monitored by a physiotherapist for 6 weeks via telerehabilitation technologies. All participants will be evaluated for back pain, knee pain, muscle thickness, muscle strength, function and balance before and at the end of the program and the data obtained will be recorded.

Eligibility Criteria:
Inclusion Criteria:

* Being between the ages of 18-30,
* According to International Physical Activity Questionnaire - Short Form Being physically active
* Not having any psychological, neurological, orthopedic and rheumatic disorders,
* Not having a history of fractures or surgeries affecting the lower extremities in the last year,
* Being able to do at least one traditional squat exercise
* Being able to communicate in Turkish (written and verbal) Exclusion criteria
* Being pregnant or suspected of being pregnant
* Knee valgus diagnosis
* Pes planus or pes cavus diagnosis in the foot
* Hip rotation diagnosis
* Strength deficit between two extremities
* A history of acute osteoarthritis in the knee
* Regular medication use or use of NSAIDs and similar disease-modifying drugs in the last month
* Intra-articular injection (hyaluronic acid/steroid) application in the last 6 months
* Having a comorbid disease that contraindicates exercise (advanced osteoporosis, vertigo, neurological diseases, etc.)