cyrilzakka/clinical-trials huggingface dataset:
Investigation of Activation of Latissimus Dorsi Muscle Segments During Functional Reach Activity in Chronic Stroke Patients

Latissimus Dorsi (LD); Medial sacrum, lumbar vertebrae and lower thoracic vertebrae 10-12 lateral to the spinous processus. It is a fan-like wide muscle that connects to the inferior angle of the scapula and ribs, adheres to the anterior surface of the proximal humerus and continues with aponeurosis of the contralateral Gluteus Maximus below. The activation of the LD muscle during the functional reach activity, which we use most frequently in daily living activities, affects the upper extremity and trunk movements. Therefore it is important muscle that affects the quality of movement.

The study include individuals with stroke that diagnosed by the neurologist and include healthy subjects. During sitting activity, they will be required to reach three different distances in the sagittal and scapular plane: arm length, 125% of the arm length and end point where it can reach the modified functional reach test. During the activity, electromyography (EMG) activation of latissimus dorsi, anterior deltoid and erector spina muscles will be examined with electromyographic device.

Hypothesis originating from the investigation:

H1: Latissimus dorsi muscle segments show different activation during functional reach activity.

H2: Activation of latissimus dorsi muscle segments is affected by reaching direction during functional reach activity.

H3: Activation of latissimus dorsi muscle segments is affected by reaching distance during functional reach activity.

Measurements will be made during the sitting activity of the individuals included in the study. Individuals will be asked to reach midsternal height cups in two separate planes, sagittal and scapular, at arm's end, 125% of arm's distance and end point where it can reach according to modified functional reach test.

Muscle activation of latissimus dorsi, erector spina and anterior deltoid muscles will be measured by superficial electromyographic measurement. Muscle activation according to SENIAM for erector spina and anterior deltoid will be evaluated. For latissimus dorsi, activation will be measured in six segments separated according to anatomic dissection.

Reach activity will be performed 3 times on each side and at 1 minute intervals.

Eligibility Criteria:
Inclusion Criteria:

* diagnosed with stroke by a neurologist
* least 6 mounts after stroke
* Fugl Meyer Upper Extremity Motor Rating Scale with a value of 40 and above,
* independent sitting,
* Mini Mental Status Scale (MMSE)\> 24,
* 30-67 age.

Exclusion Criteria:

* neurodegenerative disease other than stroke
* presence of neglect
* presence of apraxia
* uncorrected visual impairment
* neuromusculoskeletal pathologies
* neck and shoulder pain lasting more than 3 months
Molecular Effects of Vitamin B3 (Niacinamide) in Acute Kidney Injury

This is a single center, randomized, single-blind, placebo-controlled study to evaluate the safety and biochemical effects of niacinamide on metabolic parameters of the kidney in patients undergoing cardiac surgery.


Eligibility Criteria:
Inclusion criteria

1. All patients undergoing cardiac surgery with the use of cardiopulmonary bypass at high risk for acute kidney injury. A Cleveland score of 6 or more is used to define patients at high risk for acute kidney injury
2. Age ≥ 18
3. Signed informed consent

Exclusion criteria

1. Pre-existing acute kidney injury
2. Kidney transplantation
3. Off-pump heart surgery
4. Pregnancy
5. End stage renal disease
6. Pregnancy (female subjects of childbearing potential must have a negative serum pregnancy test)
7. Subjects with any kind of dependency on the investigator (e.g. any subject who is under direct supervision of the investigator/co-investigators or employed by the investigator/co-investigators) 8 Subjects held in an institution by legal or official order (e.g. subjects in jail, prison, juvenile offender facility, or treatment facility including those who are in hospitals, alcohol, and drug treatment facilities under court order, and individuals with psychiatric illnesses who have been committed involuntarily to an institution)
Holmium: YAG Versus Cold Knife Internal Urethrotomy in Management of Short Urethral Strictures

Urethral stricture disease is defined as narrowing of the urethral lumen because of fibrosis, which occurs in urethral mucosa and surrounding tissues. The etiology could be congenital, iatrogenic, infectious, or idiopathic.

Several techniques are currently available for minimally invasive treatment of urethral strictures, including cold-knife incision, electrocautery, and various types of laser incisions. An incision with the cold knife does not cause any thermal effect on surrounding tissues but should create a mechanical injury that may lead to recurrence in long term. An incision with the electrocautery should cause a significant thermal effect on healthy surrounding tissues resulting in recurrent strictures during follow-up. Laser treatment modalities have gained popularity in the last two decades.

the aim of this trial is to evaluate the safety and efficacy of endo-urethrotomy with Holmium laser and cold knife endo-urethrotomy

Urethral stricture disease (USD) is the narrowing of the urethra from scar tissue, related to genitourinary tract infections, inflammatory skin conditions, traumatic urethral injury, pelvic radiation, and urinary tract instrumentation. It has an estimated prevalence rate of 0.6%.1-3 USD is a common and challenging problem for urologists. Multiple treatment modalities are available for the management of urethral strictures depending on the site and length of stricture, this includes simple urethral dilatation, urethral stenting, endoscopic visual internal urethrotomy (VIU), or open reconstruction.

Since 1974, Sachse's internal urethrotomy has been considered the treatment of choice for USD which is fast and simple to carry out and is associated with a short recovery time. The success rates are 33%-60%.

Bulow et al in 1979 introduced the laser for internal urethrotomy. The obvious dominance of Ho: YAG are clear vision, less bleeding, precise incision and ablation of scar tissue, and short hospital admission, however, most literature assessing the adequacy of the laser in contrast to cold-knife urethrotomy show no difference in final results.

The aim of this trial is to assess the efficacy, safety, complications, and results of Holmium laser urethrotomy and cold knife internal urethrotomy for urethral stricture.

Eligibility Criteria:
Inclusion Criteria:

* men with urethral stricture above the age of eighteen were included in our trial. the length of the urethral stricture was less than 1.5 cm.

Exclusion Criteria:

* patient with complete urethral stricture with a suprapubic catheter in place.
* patients whom internal urethrotomy is not applicable like multiple urethral strictures or balanitis xerotica obliterans.
Quantitative Diffusion and Fat Imaging of the Spine

Primary Objective:

The purpose of this study is to determine whether or not combined quantitative diffusion and fat MR imaging techniques can differentiate between benign and malignant vertebral fractures.

Researchers believe that they may be able to use MRI scans to tell if fractures of the bones in the spine are due to cancer. They believe this can be done by looking at MRIs of diffusion (the random motion of molecules) and fat. For benign and malignant processes, either diffusion or fat, or both of them, can be different, because the cell density (which affects diffusion) and bone marrow content (which affects fat) are expected to be different.

All patients in this study will have already been scheduled for MRI exams of the spine at UTMDACC.

You will have one extra MRI sequence done to look for relative fat, and a second extra MRI sequence done to look for the diffusion. The extra time required for the study should be less than 10 minutes, and the total imaging time should fall within a standard MRI time slot.

Available data from your medical record, including imaging data, will be used to set up guidelines and clear examples for checking spinal fractures.

This is an investigational study. A total of 48 patients will take part in the study. All will be enrolled at UTMDACC.

Eligibility Criteria:
Inclusion Criteria:

1. Patients with suspected vertebral compression fractures scheduled a standard of care MRI of the spine.

Exclusion Criteria:

1. Patients who are contraindicated for MRI (such as due to metal implants, cardiac pacemaker).
2. Patients who are unable to give informed consent
3. Patients who are younger than 18 years of age since the disease (osteoporosis) is not present in children.
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Oral Doses of GLPG0634 in Healthy Subjects

The purpose of the study is to evaluate the safety and tolerability of multiple ascending oral doses of GLPG0634 given to healthy subjects for 10 days compared to placebo.

During the course of the study, the amount of GLPG0634 present in the blood (pharmacokinetics) as well as the effects of GLPG0634 on mechanism of action-related parameters in the blood (pharmacodynamics) will be characterized.


Eligibility Criteria:
Inclusion Criteria:

* Healthy male, age 40-60 years
* BMI between 18-30 kg/m2

Exclusion Criteria:

* Any condition that might interfere with the procedures or tests in this study
* Drug or alcohol abuse
* Smoking
Tissue Eosinophils in Non-Small Cell Lung Cancer (the TEN Study)

The primary objective is to describe eosinophil infiltration in resected (early stage) NSCLC.

Secondary objectives are:

* to investigate the correlation of T-Eos and B-Eos in the aforementioned patient population;
* to investigate the correlation between T-Eos and overall \& disease-free survival;
* to investigate the localization of T-Eos (periphery vs. center of the tumor lesions).


Eligibility Criteria:
Inclusion Criteria:

* Resected, early stage NSCLC between 01-01-2015 and 30-04-2022 with available tumour tissue

Exclusion Criteria:

* Inclusion in a clinical study contraindicating enrollment in the present study
Self-guided Treatment for Depression

This study will examine the efficacy and safety of a self-guided digital therapeutic app for the adjunct treatment of Major Depressive Disorder compared to a control app in adolescents and adults.

This study aims to examine the efficacy of a self-guided digital therapeutic app for depression compared to a control app in individuals aged 13 and older with a diagnosis of Major Depressive Disorder. The primary outcomes are patient- and clinician-reported depression symptom severity after 5 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Positive self report screen for depression
* Participant is at least 13 years of age
* Willing and able to provide informed consent; if under 18 years of age, willing and able to provide assent, and has a legal guardian willing and able to provide consent
* Primary diagnosis of Major Depressive Disorder (MDD)
* Under the care of a United States (U.S.)-based licensed healthcare provider and willing and able to provide contact information for the provider and sign a HIPAA release that allows investigator to contact provider
* Fluent and literate in English
* Has access to a compatible device and operating system (i.e., capable of installing the app from the Google Play or Apple App Store) and regular internet access
* Located in the continental U.S., Hawaii, or Alaska, and not planning to leave the U.S. during the primary study period

Exclusion Criteria:

* Has changed or initiated psychotherapy with a mental health professional within 30 days prior to eligibility screening
* Has received certain types of psychotherapy within the last 6 months
* Has changed prescribed psychotropic medication (initiation or change in dose) within the past 30 days
* Plans to initiate or change treatment (e.g., psychotherapy, psychotropic medication, and/or other psychosocial treatment) for a mental health disorder during study intervention period
* Suicidal behavior within the past year
* Active suicide ideation with intent within the past 3 months
* Previously participated in user testing or a clinical study at Limbix Health Inc. or Big Health Inc. (such as the STAND study or Rise study), or have used a Limbix app
* Participated in any other clinical research involving an intervention or treatment within the past 60 days
* Plans to participate in any other clinical research involving an intervention or treatment during the study intervention period
* Living in the same household as another participant in the study (e.g., a sibling)
* Has a diagnosis of MDD with psychotic features or comorbid Psychotic Disorder
* Has a concurrent diagnosis of (or has been treated for) bipolar disorder I and II or severe substance use disorder within the past year
* Has treatment resistant depression
* Is employed by Big Health Inc., or is a collaborator, associate, or relation of Big Health Inc. staff
* Any condition, comorbidity, or event (other than the above) that, in the opinion of the investigator, will prevent the participant from adhering to the protocol or benefitting from the intervention, or will prevent investigators from being able to ensure safety
Retrospective Analysis of Factors Affecting Chronic Postoperative Pain After Thoracotomy

The aim of this retrospective study is to determine the factors affecting the development of chronic pain in patients with thoracotomy in the Thoracic Surgery Operating Rooms of İbn-i Sina Hospital. By identifying these factors, it is aimed to apply the necessary treatments to prevent the development of chronic pain and to improve patient outcomes.

The study included 229 patients ASA 1, 2 and 3, 18 years of age and older, who underwent elective thoracotomy in Ankara University İbn-i Sina Hospital, Thoracic Surgery operating room between 01.01.2016 and 31.12.2020. The medical files and electronic records of the patients were scanned from the system. Age, gender, weight, ASA score, smoking, comorbidities (hypertension, diabetes), drug use, malignancy, chemotherapy history, radiotherapy history, intraoperative and postoperative analgesia method, duration of acute pain, type of surgery, duration of surgery, duration of anesthesia, rib resection, number of chest tubes and duration time, time to apply to the pain clinic, and the analgesic method applied were recorded.

Eligibility Criteria:
Inclusion Criteria:

* asa 1,2 and 3
* 18 year of age and older
* underwent elective thoracotomy

Exclusion Criteria:

* ASA 4 and 5, emergency or trauma thoracotomy, patients with malignancy infiltrating the chest wall, more than one thoracotomy performed, patients whose cardiovascular or cerebrovascular or musculoskeletal system was affected at a level that would affect their daily activities after surgery, and patients with insufficient data for various reasons
Surgical Site Infections at a West Cameroon Hospital

Surgical site infections (SSI) constitute an important health concern in low and middle income countries, leading to prolonged hospital stay and increased costs. Previous studies indicate that in Africa up to 1/3 of patients undergoing surgery may be affected by a postoperative infection. The development and implementation of context-specific SSI prevention guidelines is important to reduce this complication. To deploy efficient context-specific measures, data on epidemiology and microbiology of these infections are needed. This means to adapt the prevention measures to the context-specific risk factors for surgical site infections in resource-limited settings, and to give locally adapted recommendations on antimicrobial therapy based on local resistance patterns. However, data in this respect are scarce in low and middle income countries. This present study will contribute to the needed epidemiology and microbiology data on SSI in Cameroon. It will be carried out as a prospective cohort study at the Mbouo Protestant hospital in the West Region of Cameroon. The incidence, microbial spectrum and respective antimicrobial resistance of SSI as well as the risk factors of SSI will be systematically investigated. The study will include 300 patients at the Hôpital Protestant de Mbouo (HPM) who underwent surgery and gave their informed consent for inclusion, the timeframe is 04/2021 - 11/2021. An active SSI surveillance system will be put in place for 30 postoperative days to diagnose SSI.

Expected outcomes:

The incidence of SSI is likely to be higher than 10%. Concerning risk factors, preoperative bodywashing and perioperative antibioprophylaxis is expected to be protective against SSI. Up to 1/3 of SSI are expected to occur after hospital discharge. For the microbial spectrum, a high proportion of Staphylococcus aureus is likely to be found. For the antimicrobial resistance no estimation can be give as data is non-existent in that region from the literature.


Eligibility Criteria:
Inclusion Criteria:

* Patient underwent surgery at the hospital during study period

Exclusion Criteria:

* Unconscious patients, mentally ill patients
Observational Study of Early Contact With Palliative Care Unit for Patients Receiving First Line Palliative Chemotherapy With Cancer in Upper Gastrointestinal Canal, or Second Line Palliative Chemotherapy in Patients With Colorectal Cancer - an Open, Randomised Investigator Initiated Trial.

In this trial, patients with cancer in the upper gastrointestinal canal who are going to receive first line palliative chemotherapy and patients with colorectal cancer who are going to receive second line palliative chemotherapy will be included. Participating patients will be randomized between early contact with a palliative care unit, or contact with a palliative care unit when needed. The objectives with the trial is to investigate if an early establishment with a palliative care unit will have a positive impact on the patients quality of life, this also applies for the nearest relative, survival, and if a difference in numbers of chemotherapy cycles can be detected.


Eligibility Criteria:
Inclusion Criteria:

* Patients with tumor in upper gastrointestinal canal, who is going to start treatment with first line palliative chemotherapy
* Patients with colorectal cancer, who is going to start treatment with second line palliative chemotherapy
* Signed written informed concent

Exclusion Criteria:

* Patients with neuroendocrine tumor
* Patients with already ongoing chemotherapy
* Patients with already established contact with palliative care unit
Focal Prostate Ablation Versus Radical Prostatectomy

This study aims to compare the treatment results of HIFU and Radical prostatectomy.

The FARP randomized control study will compare focal ablation of prostate using High Intensity Focused Ultrasound (HIFU) applied by FocalOne® or TULSA® device versus Radical Prostatectomy (RP) in patients with unilateral, intermediate risk prostate cancer.

Eligibility Criteria:
Inclusion Criteria:

* Positive MRI (PIRAD 3-5) and biopsy proven unilateral prostate cancer classified as ISUP 1 (with cancer core length \> 5mm) or ISUP 2-3 (any length) not eligible to active surveillance or watchful waiting
* PSA ≤ 20 ng/ml
* Treatment naive patients with localized prostate cancer (stage ≤ T2b)

Exclusion Criteria:

* Clinical stage T\> 2b
* Metastatic lymph node on imaging
* Patients already treated for Pca (hormone therapy, EBRT)
* Patients with contra-indications to MRI
* Patients with active inflammatory bowel disease or previous rectal fistula
* History of previous pelvic radiotherapy
* History of bladder cancer
* History of bladder neck or urethral stricture
* Urogenital infection in progress
* Allergy to latex or gadolinium
* Patients on life support or suffering form unstable neurological diseases
Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants

The purposes of this study are to compare the outcomes of the biodegradable implants for the fixation of ankle fracture and those of metallic implants, and to assess the problems of the biodegradable implants. Null hypothesis is that the clinical outcomes of biodegradable plate and screws for ankle fracture are not different from those of metallic implants.


Eligibility Criteria:
Inclusion Criteria:

* skeletally mature subjects (≥16 years old) with unilateral ankle fractures

Exclusion Criteria:

* subjects less than 16 years old,
* subjects not followed up at this hospital,
* multiple injuries,
* bilateral ankle fractures,
* open fractures,
* pathologic fractures,
* concomitant tibial shaft fractures,
* previous history of immobilization due to significant injury or a fracture of either ankle,
* significant peripheral neuropathy,
* soft tissue infection in the region on either injured ankle,
* or inability to complete the study protocol
Donepezil Trial for Motor Recovery in Acute Stroke

AIMS: To establish: 1) whether motor deficits in acute stroke improve more in patients taking donepezil, relative to placebo, for 12 weeks; 2) whether brain functional MRI changes as a result of donepezil after 12 weeks.

Stroke is a major personal and social burden, being the commonest cause of severe adult disability. Recovery has been shown in animal models to be dependent upon adequate levels of acetylcholine within the brain - which in stroke is likely to be deficient. This is because acetylcholine-producing nerve cells in the brain are often damaged by strokes.

Consequently, the investigators hypothesise that recovery may be improved by boosting acetylcholine levels in the brain - that can be readily achieved by treating with donepezil.

Eligibility Criteria:
Inclusion Criteria:

1. Patients diagnosed with acute stroke diagnosed on clinical and neuroimaging grounds who can enter the trial within the 1st week of stroke onset, and who have new motor dysfunction of an upper limb. Motor impairment should be moderate - severe (UE-FM Score ≤50 out of a total of 66).
2. Age: above 18 years old.
3. Patients able and willing to partake in motor tests, and to return for follow-up visit at 12 weeks.
4. Able to understand English.

Exclusion Criteria:

1. Contraindications for donepezil: pregnancy (\* Female patients \<50 years old will be asked if there is any possibility that they might be pregnant. If there is any uncertainty, or a likelihood that they are pregnant, this will qualify as an exclusion criterion)\*; moderate - severe asthma (i.e. regular treatment prescribed for this); bradycardia, syncope, 2nd or 3rd degree heart block, acute or decompensated heart failure; peptic ulcer diagnosed endoscopically and on treatment for this; epilepsy; Parkinson's disease; end-stage renal failure or creatinine \> 300 micromol/l; genitourinary tract or gastrointestinal tract obstruction; gastrointestinal tract hemorrhage; myasthenia gravis
2. Other: functionally-significant cognitive impairment (i.e. dementia); significant receptive aphasia (i.e. such that cannot understand purpose or details of trial, and will be unable to cooperate with task instructions); significant physical infirmity as judged by treating physician (e.g. severe organ failure; terminal cancer).
3. Contraindications for MRI (this only pertains for the subset of patients entering the MRI substudy, but is not a contra-indication to the main study providing a diagnosis of stroke is clear from CT): phobia, metal implants including pacemaker.