cyrilzakka/clinical-trials huggingface dataset:
The Diagnostic Value of APTT/Fibrinogen Ratio in Pulmonary Embolism

From January 1, 2023 to December 30, 2023, patients who were suspected of pulmonary embolism and underwent CTPA examination at Nanyang Hospital of Southern Medical University were divided into pulmonary embolism group and non pulmonary embolism group. 1. Collect relevant data, including gender, age, primary disease, CTPA imaging and reports, BNP, troponin, electrocardiogram, cardiac ultrasound, PT, APTT, TT, fibrinogen, D-dimer, etc., and analyze demographic data, pulmonary embolism risk grading, APTT/fibrinogen ratio, and determine their cut-off values through statistical analysis of the two groups. 2. Follow up on the APTT/fibrinogen ratio after anticoagulation treatment and bleeding in the pulmonary embolism group.


Eligibility Criteria:
Inclusion Criteria:

1. Voluntary signing of informed consent form;
2. When signing the informed consent form, the age is equal to or greater than 18 years old, regardless of gender;
3. From January 1, 2023 to December 30, 2023, the patient was diagnosed with suspected pulmonary embolism at the Southern Hospital of Southern Medical University and underwent enhanced pulmonary artery scanning examination.

Exclusion Criteria:

1. Patients with gastrointestinal bleeding, severe trauma, acute coronary syndrome, severe liver disease (childC grade), and coagulation dysfunction;
2. Patients with pulmonary embolism diagnosed outside the hospital and regular anticoagulation;
3. Patients undergoing regular anticoagulant therapy such as atrial fibrillation and valve replacement;
4. Patients deemed unsuitable for participation in this study by the researchers.
Frailty and Post-operative Complications in Older Surgical Patients: The Implication of Frailty and Preoperative Risk Assessment

Frailty is prevalent in older adults and may be a better predictor of post-operative morbidity and mortality than chronological age. Preoperative risk factors and physiological reserves were assessed on patients more than 70 years old who are scheduled for surgery under general or regional anesthesia. The aim of this retrospective analysis was to examine the impact of relevant geriatric assessments on adverse outcomes in older surgical patients.

The goal of this study is to analyze the effect of frailty status on postoperative outcomes. These include postoperative complications (only ICD-10 coded diagnoses), length of hospitalization (ward/ICU), disposition, and survival. The project will also attempt to find synergism between a positive frailty status and common medical conditions (e.g. diabetes, congestive heart failure, coronary artery disease, dementia, and kidney disease), as well as anesthesiological and surgical processes (e.g. duration and type of anesthesia, surgical risk, and surgical discipline). Different assessment tools will be analyzed regarding their predictive power and clinical practicability. This should help improve preoperative risk assessment and allow for the multidimensional (physical, cognitive, social) identification of relevant frailty characteristics in the perioperative setting. All outcome parameters, including admission and discharge periods, will be collected using coded information from our hospital database. There will be no follow-up measurements after hospital discharge.

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients with age 70 years and above scheduled for surgery in the Department of Anesthesiology and Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin
Optimizing Resuscitation After Cardiac Arrest in the Community

Resuscitative efforts have been shown to be unsuccessful in most cases of out-of-hospital cardiac arrest (OHCA), and survivors who do recover cardiac function often sustain severe hypoxic brain damage. Time to efficacious care is a primary determinant of disability-free survival. In the Jerusalem district, only 9% of OHCA patients present with ventricular tachycardia/ventricular fibrillation (VT/VF) as the primary rhythm, whereas 77% present with asystole; this seems primarily to be the result of long collapse-to-arrival times. Nevertheless, overly zealous resuscitation is undertaken in a high proportion of arrests with a futile prognosis, leading to excessive costs.

Study hypotheses:

1. Subpopulations for whom intervention is futile/counter-productive are identifiable
2. Substantial waste of resources can be avoided
3. Optimization of emergency medical services (EMS) reorganization without adding resources is an achievable goal


Eligibility Criteria:
Inclusion Criteria:

* All victims of non-traumatic out-of hospital cardiopulmonary arrest (defined as the absence of either spontaneous respiration or palpable pulse or both) within the Jerusalem district.

Exclusion Criteria:

* Patients with do-not-resuscitate orders or an advance directive to that effect.
GMK-UNI Anatomical UKA: Fixation of Cemented Vs Cementless Designs

Unicompartmental knee arthroplasty (UKA) is the principal surgical alternative to the total knee arthroplasty (TKA) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee. The current comparative randomized study aims to evaluate the fixation of cemented and cementless designs of GMK-UNI unicompartmental knee prosthesis over a 5-year time period.

The Primary objective is to compare the quality of fixation of cemented and cementless designs of GMK-UNI unicompartmental knee replacement at 2 years of follow-up.

The Secondary objectives include the evaluation of the patient improvement (subjective and objective) using the new Knee Society Score (KSS); the patient's anterior pain following UKA and any eventual patella-femoral disorder; Implant survival rate using the Kaplan Meier analysis; Post-op radiological findings and Adverse Events.

The Primary outcome aims to compare the occurrence of radiolucency's lines (both partial and complete) between the two study groups. Secondary outcomes include New KSS, OKS, Kaplan Meier analysis and stability and fixation of UNI prosthesis.

All patients who meet the inclusion criteria to take part in the current clinical study will be invited to participate before the surgery.

Subjects will be randomized during the screening; half of them will receive the cemented GMK-UNI anatomical UKA and the other half the cementless GMK-UNI anatomical UKA.

Clinical data will be recorded on CRF at those time-points:

* Before the surgery
* During the surgery
* After the surgery at 3 months, 1, 2, 3 and 5 years.

Eligibility Criteria:
Inclusion criteria:

* Patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee that meet the indications for use according to Medacta implants included in this study (on-label use);
* Those suffering from unilateral osteoarthritis or osteonecrosis of the medial compartment;
* Frontal deformity \< 10° (evaluated on weight-bearing long-axis x-rays);
* Flexion contracture \< 10°;
* Intact ligaments;
* Patients who are willing and able to provide written informed consent for participation in the study. Written informed consent must be obtained prior to the patient's surgery;
* Patient's age over 18 years old;
* Patient with BMI \< 40 kg/m2;
* Patients must be willing to comply with the pre and post-operative evaluation schedule.

Exclusion criteria:

* Patients with one or more medical conditions identified as a contraindication defined by the labelling on any Medacta implants used in this study;
* Any patient who cannot or will not provide informed consent for participation in the study;
* Patients who need to undergo lateral unicompartmental knee arthroplasty;
* Patients who need a revision surgery;
* Patients who need a patella-femoral joint prosthesis;
* Patients who had previously undergone high tibial osteotomy or ACL reconstruction;
* Patients with BMI ≥ 40 kg/m2;
* Patients unable to understand and take action;
* Any case not described in the inclusion criteria;
* Patients aged under 18 years;
A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED)

The purpose of this study is to determine the mumps virus strength at the end of shelf-life (expiration date) of an approved vaccine.


Eligibility Criteria:
Inclusion Criteria:

* Healthy children 12 to 18 months of age

Exclusion Criteria:

* History or prior exposure to measles, mumps, rubella or varicella
* History of anaphylactoid reactions or hypersensitivity to any component of the vaccine, including gelatin and neomycin
Gross Motor Function and Living Skills in CP

Cerebral palsy (CP) is non-progressive disorder, which undergoes mishap to the developing brain and it affects a person's ability to move and maintain balance and posture. Old name of CP is "Little's disease".Through social and community participation, children and youth with cerebral palsy (CP) form friendships, gain knowledge, learn skills, express creativity, and determine meaning and purpose in life. The purpose of this study is (1) to determine whether social and community participation of children and youth with CP differ based on age, sex, and gross motor function, and (2) to identify the types of activities in which social and community participation are highest

Those participants will be excluded having any unstable medical condition that precluded safe community physical activity, any orthopedic or neurological surgery in the previous 6 months, moderate to profound intellectual disability, moderate to severe communication disability, severe visual impairment, any sensory impairment or psychological disorder. The tools that will be used are WHODAS 2.0(WHO Disability Assessment Schedule), Washington Group Short Set of Disability Questions, Child and Adolescent Scale of Participation Activities of Daily Living, Functional Mobility and Participation. Data will be analyzed on SPSS version 25, normality of the data will be checked and data will be presented in the form of descriptive statistics, mean, SD range correlation.

Eligibility Criteria:
Inclusion Criteria:

Washington Group on Disability Statistics (WG) score greater than or equal to 12.

* Children with age group of 6 to 12 years.
* With diagnosis of CP.
* WHOdas Cognition - score 2.5.
* Mobility - score 2.5.
* Self-care - score 2.5 attending to one's hygiene, dressing, eating and staying alone.
* Getting along -score 2.5 interacting with other people.
* Life activities -score 2.5 domestic responsibilities, leisure, work and school.
* Participation - score 2.5 joining in community activities, participating in society

Exclusion Criteria:

Any unstable medical condition that precluded safe community physical activity.

* Having any orthopedic or neurological surgery in the previous 6 months.
* Moderate to profound Intellectual disability.
* Moderate to severe communication disability.
* Severe visual impairmen
Intravenous Lidocaine for Laparoscopic Cholecystectomy

Intravenous lidocaine has been shown to have analgesic, antinflammatory, antihyperalgesic, antithrombotics and neuroprotective properties. In a previous study conducted in patients undergoing laparoscopic cholecystectomy under general anesthesia with desflurane and fentanyl, intraoperative i.v. infusion of lidocaine spared opioids consumption in the recovery room by 30%.

The purpose of this study was to determine if an i.v. infusion of lidocaine without intraoperative opioids would reduce the amount of fentanyl to the same extent and opioids-related side effects.


Eligibility Criteria:
Inclusion Criteria:

* patients undergoing laparoscopic cholecystectomy

Exclusion Criteria:

* age \<18 yr or \> 85 yr,
* ASA physical status 3 and greater, history of hepatic failure (Child \& Pug A-C),
* renal failure (creatinine outside the normal range) or cardiac failure (NYHA I-IV),
* Adams-Stoke syndrome,
* severe degrees of sinoatrial, atrioventricular or intraventricular block,
* organ transplant,
* diabetes mellitus type 1 and 2,
* morbid obesity (BMI \> 40),
* chronic use of opioids and beta-blockers,
* known seizures,
* severe mental impairment,
* allergy to local anesthetics and to all the medications used in the study, or
* inability to understand pain assessment.
Correlation Between Quadratus Lumborum , Pelvic Floor Muscles and Diaphragm in Patients With Urinary Incontinence

The purpose of this study is to investigate Correlation between quadratus lumborum , pelvic floor muscles and diaphragm in patients with urinary incontinence

50 patients were distributed randomly into two groups. The first group measured ultrasound imaging for quadratus lumborum , pelvic floor muscles and diaphragm urinary incontinence female The second group measured ultrasound imaging for quadratus lumborum , pelvic floor muscles and diaphragm urinary incontinence female normal females.

Patients examined with medical ultrasound imaging .

Eligibility Criteria:
Inclusion Criteria:

* - Their ages varied from 30to 40years, their body mass index (BMI) was 25-30 kg/m2 and a number of parities ≤ three normal vaginal deliveries, at least two years and Subjects hadn't received drugs , urinary incontinence mild or modrate

Exclusion Criteria:

- 1. History of spinal surgery or spinal fracture. 2. Volunteers with a history of a recto-vaginal or vesico-vaginal fistula, undiagnosed uterine bleeding urinary tract infection, diabetes, intrauterine device, chest and/or cardiac disease and using any drugs for urinary incontinence 3. Serious diseases, such as heart disease, kidney, liver diseases, gastric ulcer or duodenal ulcer.

4. A history of bronchial asthma or any chest disease. 5. Uncontrolled diabetes or hypertension. 6. Patients with peacemaker or any metal implant on the treated area. 7. Cancer or patient with past history of tumor excision.
The Effect of Dairy on Bone Mass and Body Composition in 4th-8th Grade Boys and Girls

Building stronger bones during pubertal growth could reduce lifelong fracture risk. This project is an 18 month dairy intervention study for overweight and healthy weight 4th-8th grade boys and girls. Half of the girls will receive dairy products to add to their habitual diet (milk, yogurt, and cheese) to equal three products per day, while the other half will remain on their normal diet. All participants will attend four study visits, each 6 months apart. At these visits height, weight, bone density and geometry, and fat and lean mass will be measured. This study aims to show that meeting calcium requirements by eating dairy products builds bigger, stronger bones, and that this effect may be enhanced in overweight boys and girls. The effect of the dairy intervention on body fat, lean mass, and weight, as well as the mechanisms and predictors of changes in bone mass and size and body composition will also be evaluated.


Eligibility Criteria:
Inclusion Criteria:

* Males and females in 4th-8th grade
* Generally healthy
* BMI percentile 5-70% for age or \>85% for age
* Baseline calcium intake less than or equal to 800mg/d

Exclusion Criteria:

* History of any illness known to affect bone mass accrual (diabetes, inflammatory bowel disease, childhood malignancy).
* A broken bone in the last six months.
* Consume more than 800 mg Calcium/d.
Berberine Effect on Cytokine, CRP, Metabolic Disturbance as an Adjunctive Therapy in Schizophrenia Patients

The etiology and pathogenesis of schizophrenia remains unclear. Immune dysfunction hypothesis for schizophrenia has attracted increasing attention of the researchers, substantial evidences suggested the levels of C-reaction protein and cytokine such as IL-1β, IL-6, TNF-α markedly elevated in patients with schizophrenia which may be particularly relevant for the cognitive impairment and metabolic disturbance of schizophrenia. In recent years, it has been demonstrated the beneficial effects of berberine on regulating lipid and glucose metabolism, reducing the proinflammatory status and improving cognition. As the investigators known, the report of berberine being used in schizophrenia is rare. This protocol is aim to evaluate berberine, as an adjunctive therapy, on inflammatory markers, lipid and glucose metabolism, cognition in patients with schizophrenia.


Eligibility Criteria:
Inclusion Criteria:

* Individuals who age 18 to 60 years diagnose schizophrenia according the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID).
* The patients have illness for less than 5 years and have stable dose of the current antipsychotic drug for at least one month.
* Well established compliance with inpatient treatment per treating clinician's judgment. On baseline, at least 60 for Positive and Negative Syndrome Scale (PANSS) total score.
* Able to complete the cognitive assessment battery Female subjects will be eligible to participate in the study if they are of non-childbearing potential or of child-bearing potential and willing to practice appropriate birth control methods during the study.

Exclusion Criteria:

* Individuals who refuse to provide informed consent.
* Currently substance abuse or psychiatrically unstable per treating clinician's judgment.
* One with significant medical illnesses including uncontrolled hypertension, diabetes, seizure disorder, severe cardiovascular, cerebrovascular, pulmonary, or thyroid diseases also not suitable for this trial.
* Currently on anti-inflammatory or immunosuppressant medication including oral steroids and history of chronic infection (including tuberculosis, HIV and hepatitis), malignancy, organ transplantation, blood dyscrasia, central nervous system demyelinating disorder, and any other known autoimmune or inflammatory condition pregnancy or breastfeeding.
Evaluation of SGLT2-i Effectivness and Safety in Elderly Type 2 Diabetes Patients

The aim of the study is to evaluate the benefits, documented in experimental settings, of treatment with SGLT2-i in subjects with type 2 diabetes and older than 70 years in normal clinical practice.

The type of study does not involve immediate risks or direct benefits for the subjects taking part in it. The potential benefits for clinicians and healthcare systems are: greater knowledge of diabetic disease and the study of new treatment options. However, the analysis of the data will allow us to better identify which patients benefit most from treatment with glycosurics.

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) may have important benefits for the elderly with type 2 diabetes (T2D), however some safety concerns still limit their use in patients over 70 years of age. The SOLD study (SGLT2-i in Older Diabetic patients) aim to evaluate which basal characteristics of the patients are more frequently related to the suspension of treatment with SGLT2-i in a real-life setting.

Eligibility Criteria:
Inclusion Criteria:

* Informed consent issued before any other activity related to the study (i.e. any activity related to data collection according to the study protocol);
* Diagnosis of type II diabetes mellitus, according to ADA indications for at least 3 months
* Males or females \> 70 years old
* Stable therapy for at least 3 months with oral hypoglycemic agents / insulin
* Prescription of SGLT2 inhibitors, in accordance with normal clinical practice and local drug prescription / reimbursement guidelines.

Exclusion Criteria:

* Mental incapacity, unavailability or language barriers that preclude adequate understanding or cooperation;
* Diagnosis of type 1 diabetes mellitus, MODY (maturity-onset diabetes of the young), LADA (latent autoimmune diabetes in adults), gestational diabetes mellitus, secondary diabetes mellitus or any other hyperglycemic state other than T2D;
* Previous participation in the study. Participation is defined by having given informed consent to the study;
* Participation in another clinical study on T2D that includes any clinical intervention or administration of an investigational drug within 3 months prior to enrollment in the study
Distance Healing in Wound Healing

This trial examines the impact of patients' knowledge of an experienced distant healer's efforts to heal them on measures of wound healing, psychosocial functioning, and physiological symptoms after plastic surgery.


Eligibility Criteria:
Inclusion Criteria:

* Women undergoing major plastic surgery (\> 2 hours in length)
* Health status is excellent with no systemic disease, no limitation on activity, no danger of death or disease of one body system, well-controlled underlying disease

Exclusion Criteria:

* Remove history of breast or other cancers
* History of radiation therapy to the abdomen or any radiation within the past three months
* Non-English speaking
* Unable or unwilling to fill out questionnaires
* Current smoker
* Morbid obesity
* Circulatory inadequacies (i.e., diabetes, hypovolemia)
* Nutritional deficits as evidenced by neutropenia (WBC \<2500/ml) or hypoalbuminemia (albumin \<3.3mmg/dl) / chart review
Cola Ingestion for Esophageal Bolus Impaction

The aim of the study is to observe whether cola ingestion can improve the 24-hour remission rate of acute esophageal impaction in patients with esophageal cancer.


Eligibility Criteria:
Inclusion Criteria:

1. Patients with primary esophageal lesions diagnosed by pathology, being able to consume at least a liquid diet normally before and diagnosed by a physician with acute esophageal impaction (acute esophageal impaction refers to the sudden occurrence of complete obstruction of eating within the past week)
2. Prior to enrollment, the patient did not consume carbonated beverages such as cola, or any other treatment for esophageal impaction.
3. Age ≥ 18 years old, ECOG score is 0-2 points.
4. The subjects voluntarily enrolled and obtained an informed consent form signed by the patient or their legal representative.

Exclusion Criteria:

1. It is known that complete esophageal obstruction is caused by tumor progression.
2. Patients who have been diagnosed with or highly suspected of having esophageal fistula through endoscopy or imaging prior to enrollment.
3. Patients with nasogastric nutrition tube and esophageal stent implantation
4. Patients who have symptoms such as coughing and are unable to drink cola, or who are at serious risk of aspiration (Glasgow Coma Scale\<14 or previous history of aspiration).
5. Benign diseases such as gastroesophageal reflux, cardiac arrest, and congenital esophageal stenosis that can easily lead to foreign body impaction in the esophagus.
6. Patients with coagulation dysfunction, thrombocytopenia, or taking anticoagulant drugs that are medically considered contraindications for endoscopic examination and treatment.
7. According to the researchers' assessment, patients may not be able to cooperate with the examination and treatment, or there may be other factors that could force them to terminate the study midway, such as having other serious illnesses (including mental illnesses) that require concomitant treatment, severe abnormal laboratory test values, family or social factors, which may affect the safety of the patients or the collection of experimental data.
Assessment of the Prosthetic System Impact on Mental Workload in Above-knee Lower Limb Amputees.

New generation of lower limb prosthesis provide improved functionalities. They are usually studied in the scope of biomechanics, sometimes PROMs like quality of life. Following users feedback, it is desirable to better understand why and how mental workload is impacted by new technologies or features. This clinical investigation will try to measure a difference between different prosthetic systems, in lab and in daily life.

Multicentric, national, observational, prospective study, using AB type SCED.

Eligibility Criteria:
Inclusion Criteria:

* above-knee lower limb amputation
* using an above-knee prosthesis with prosthetic knee and foot
* eligible to use Synsys
* able to design therapeutic objectives for the GAS
* having a smartphone

Exclusion Criteria:

* protected person
* pregnant or breast-feeding lady
* knee-to-ground height lower than 43cm
* weighting more than 125kg
* using their prosthesis for less than 2 weeks
* not covered by health insurance
* aged less than 18 or more than 84 years old
* bilateral amputee or hip disarticulated