cyrilzakka/clinical-trials huggingface dataset:
Evaluation of Astaxanthin Properties on Anti-fatigue

Ten young, healthy, physically active male college students were crossed over for AST or placebo supplements randomized into placebo or AST trials and orally consumed placebo or AST (28 mg/d) supplements for four days. Short-term AST supplementation enhanced endurance performance and effectively reversed cycling challenge-induced muscle damage and lipid peroxidation.

AST is composed of two β-ionone ring systems that are linked by a polyene chain and contain oxygenated keto and hydroxyl moieties, which are responsible for its powerful antioxidant activity. AST has been shown to have numerous health benefits in humans, including improved antioxidant and inflammatory status under different stress conditions. Therefore, this study will explore AST supplement to improve exercise-induced muscle damage and/or physiological anomalies in adults. Ten physically active male adults were randomized into placebo or AST trials and consumed placebo or AST (28 mg/d) supplements orally for 4 days. On day-4, participants performed an exhaustive cycling challenge at 75% V̇O2max, and the time to exhaustion (TTE) was recorded. Blood and gaseous samples were collected before, during, and immediately after cycling to determine changes in muscle damage, inflammation, oxidative stress, and substrate utilization.

Eligibility Criteria:
Inclusion Criteria:

* Recruit people who are healthy are 20-40 years male and have exercise habits in college students

Exclusion Criteria:

* Have smoking and drinking habits.
* Those who have implanted artificial joints in the past six months and have had recent surgery.
* People who feel unwell due to other reasons during the experiment.
* Take any drugs or Nutrition supplements in the past 3 months.
PUFAs in Preterm Infants

The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic attributes of PUFAs in premature infants and their interplay with the onset of diseases. This study anticipates furnishing a theoretical foundation for the rationalization of PUFAs supplementation in premature infants and for informing strategies related to disease prevention and management.


Eligibility Criteria:
Inclusion Criteria:

Infants born between 24 and 36 weeks of gestational age who are admitted within 24 hours of birth, including both premature and full-term newborns.

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Exclusion Criteria:

Infants with severe congenital developmental abnormalities, those requiring external supplementation of PUFAs in addition to standard intravenous nutrition and breastfeeding, and those with a severe prognosis indicating non-survival during their hospitalization.

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Pulmonary Disease Requiring Ambulatory Oxygen Therapy -Resilience and Quality of Life

Dyspnea is common symptom in pulmonary diseases, like chronic obstructive pulmonary disease (COPD) or other pulmonary disease. Ambulatory oxygen therapy is often prescribed to these patients. In these patients resilience, health related quality of life, life satisfaction are measured and the effect and patient satisfaction to ambulatory oxygen therapy are studied.

Dyspnea is a common symptom in pulmonary disease patients, such as chronic obstructive pulmonary disease (COPD) and interstitial lung diseases. These patients often have low health-related quality of life (HRQoL) and life satisfaction (LS), and high levels of anxiety and depression.

Oxygen therapy is used in severe pulmonary diseases to improve HRQoL and prolong survival. Ambulatory oxygen therapy is prescribed to patients who become transiently hypoxemic, e.g. during exercise or normal outdoors activities. However, only 46 % of COPD patients were adherent to long-term oxygen therapy. Proper adaptation to a serious illness, such as advanced COPD and interstitial lung diseases, necessitates resilience. Resilience is an ability to adapt appropriately in difficulties in life. This ability is based on a person's psychological resources, and it can be learned and improved with time and effort. Evaluation of resilience is commonly applied in psychological examinations and research, but less attention has been paid in medical context even though resilience capacity is closely connected to recovery abilities and adaptation.

The main aim is to measure resilience in pulmonary disease patients receiving ambulatory oxygen therapy and how it correlates with other measures of HRQoL and LS. Also anxiety and depression are surveyed and satisfaction to ambulatory oxygen therapy devices and associated services.Investigators also compare the HRQoL of pulmonary disease patients receiving ambulatory oxygen therapy to an age and gender matched sample of the general population. Primary outcome measure was the proportion of patients with low resilience, and secondary outcomes were how resilience correlated with HRQoL, LS, anxiety and depression in patients prescribed ambulatory oxygen therapy.

Eligibility Criteria:
Inclusion Criteria:

* Patient with pulmonary disease (e.g. COPD) who has ambulatory oxygen
* Patient with pulmonary disease (e.g. COPD) who is starting to use ambulatory oxygen
* Adult patient
* Informed consent of the patient received

Exclusion Criteria:

* Ambulatory oxygen prescribe for treatment of other than pulmonary disease.
* Age less than 18 years
* Dementia or other cognitive impairment that disables understanding of the study
* No informed consent
Internal Carotid Artery Blood Flow in Pediatric Moyamoya Patients

Little is known about how general anesthesia-induced decrease in cerebral blood flow in pediatric moyamoya pateints. We investigated this question in patients undergoing moyamoya surgery, hypothesizing that cardiorespiratory changes during this procedure would reduce cerebral perfusion.


Eligibility Criteria:
Inclusion Criteria:

* pediatric patients undergoing encephaloduroarteriosynangiosis surgery for moyamoya disease

Exclusion Criteria:

* cutaneous lesion on the neck
Childhood Body Composition and Brain Structure and Function

The specific aim of this research project is to use MRI methods to evaluate and compare brain structure and function in normal weight and obese children age 8-10 years.


Eligibility Criteria:
Inclusion Criteria:

* Healthy normal weight or obese children
* Parental report of full-term gestation
* Parental report of birth weight between 5th-95th percentiles
* Parental report of breastfeeding or cow's milk formula fed during infancy
* Right hand dominance

Exclusion Criteria:

* Maternal diabetes
* Maternal alcohol, tobacco or drug use during pregnancy
* Chronic sleep disorder
* History of psychological or psychiatric diagnosis
* History of neurological impairment or injury
* Surgical implant or other foreign object in the body which may be a MRI safety concern
* Dental work which may cause artifacts in MRI
* Claustrophobia
* High likelihood of inability to tolerate loud noise from the MRI scanner
Study of Motor Representations in Healthy Subjects and Amnestic MCI

Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.

Eligibility Criteria:
Inclusion Criteria:

* Obtaining the signature of consent to participation in the study
* Age above 18 years
* Lack dementia as NICDS-ADRDA criteria
* Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
* Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
* No cons-indication for performing a brain MRI.
* Witennses, population of young (\<40 years)
* Witnesses ,population of older subjects (\> 60 years)
* Witnesses Lack of MCI
* MCI patients, criteria MCI criteria according to Dubois

Exclusion Criteria :

* Refusal of MRI.
* Contraindications to brain MRI.
Comparison of Two Protocols of Misoprostol (PGE1) and the Rate of Cesarean Section Due to Failed Induction.

To compare two protocols of misoprostol use for cervical ripening: 3 doses (25 ug vaginal each) or up to six doses, every six hours, until an adequate cervical condititon was achieved (BIshop score \> 6). In the first group, after 3 doses, the patient was sent to the delivery room for induction with oxytocin and in case of failure, a cesarean section was indicated for this reason. In the second group, up to six doses were used in a similar fashion. Rates of success were evaluated, as well as maternal and fetal complications.


Eligibility Criteria:
Inclusion Criteria:

* Pregnant women between 34 and 42 weeks of gestation.
* Obstetric indication for termination of pregnancy.
* No fetal evidence of fetal distress

Exclusion Criteria:

* Any contraindication for the use of misoprostol.
* Oligohydramnios.
Association of Centre of Excellence Self-Administered Questionnaire (CESAM) Score and Frailty Levels

This study evaluates the association of the Self-Administered questionnaire (CESAM) score and its stratification of frailty in four levels with incident adverse health events in older community dwellers and to compare this association with three validated frailty indexes which are the Cardiovascular Health Study frailty index, Study of Osteoporotic Fracture index and Rockwood frailty index.

Older adults' health and functional status is heterogeneous because of the various cumulative effects of chronic diseases and physiologic decline, contributing to a vicious cycle of increased frailty. Thanks to advances in medicine and hygiene, a growing number of older adults spend more years with a greater range of disorders causing disability but not mortality. Health systems thus need to face this new challenge. Quantification of frailty and its association with the occurrence of adverse health events is crucial to understand how efficiently health systems may respond to this situation.

This study aims to examine the association of the CESAM score and its stratification of frailty in four levels with incident adverse health events in older community dwellers and to compare this association with a) five validated frailty indexes which are the Cardiovascular Health Study frailty index, Study of Osteoporotic Fracture index, Rockwood frailty index, 6-item brief geriatric assessment (BGA) and "Program of Research on the Integration of Services for the Maintenance of Autonomy" (PRISMA-7) and b) two new frailty indexes developed over the COVID-19 pandemic which are "Évaluation SOcio-GÉriatrique" (ESOGER) and "CriblAge et REcommandations" (CARE).

Eligibility Criteria:
Inclusion Criteria:

-Healthy community-dwellers from Quebec, Canada

Exclusion Criteria:

-Community-dwellers from outside Quebec, Canada
Investigating if a Stronger tDCS Intensity is More Effective for Improving Naming Ability in People Living With Alzheimer's Disease

There is currently little symptomatic therapy for Alzheimer's Disease (AD) and nothing effective for individuals with Frontotemporal dementia (FTD). However, neuromodulation with transcranial direct current stimulation (tDCS) has the potential to be a clinically effective therapy for both AD and FTD. The challenge now is to specify the parameters and conditions under which tDCS is most effective to transition from the laboratory to clinical medicine. tDCS studies typically report significant group effects despite the variability demonstrated among participants, with some showing clear, meaningful improvement, while others only show statistical improvement or none at all. These variable results may be related to the conventional stimulation intensity level of 2mA. The investigators predict that administering tDCS at 4.0 mA, a more significant number of participants would show a meaningful response, and those who improve at 2mA may improve even more from 4.0mA due to having a larger electric field produced. The investigators aim to test this hypothesis in people with Alzheimer's Disease.


Eligibility Criteria:
Inclusion Criteria:

* Mild to Moderate AD
* Score between 18 and 25 on the MoCA
* Score on the Cambridge Naming Task during the pre-assessment

Exclusion Criteria:

* No history of stroke or TBI
* No shunts or metal in the body
* No history of significant heart disease, alcoholism and drug use
ASXL-Related Disorders Natural History Study

A registry focused on the natural history, management and treatment of patients with Bohring-Opitz Syndrome (ASXL1), Shashi-Pena Syndrome (ASXL2) and Bainbridge-Ropers Syndrome (ASXL3).

Study participants will be asked to complete a series of brief surveys over time about their medical condition. The researchers will also attain primary medical records.The registry is based at UCLA as the IRB of record with collaborating sites at Boston Children's Hospital, Cincinnati Children's Hospital, and Duke University in a partnership with the Bohring-Opitz Syndrome (BOS) Foundation and ASXL-Rare Research Endowment (ARRE). The BOS Foundation and ARRE are non-profit organizations run by families of patients with ASXL-related disorders that are focused on supporting research. The data is co-managed by the researchers and the family groups. Aggregate data from the Registry will be shared with the participants as well as used for publication. The Registry is HIPPA compliant and follows all the IRB requirements regarding securing and managing patient data.

Eligibility Criteria:
Inclusion Criteria:

* Clinical or molecular diagnosis of an ASXL related disorder

Exclusion Criteria:

* No clinical or molecular diagnosis of an ASXL related disorder
Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2

The goal of this study type: clinical trial\] is to learn the effect of Botulinum Toxin _A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth .

Primary outcome is keratinzed tissue width. Researchers will compare Coronally Advanced flap with De-epithelized free gingival graft and Botulinum toxin-A injection in Mentalis muscle with coronally advanced flap with De-epithelized free gingival graft alone .

The outcome will be measured at baseline, after 3 months and after 6 mobths _medical history

* 3 mm horizontal incisions, then two vertical incisions
* deepitheliztion of anatomical papillae
* superficial and deep incisions
* harvesting DFGG
* Suturing
* BOTOX injection


Eligibility Criteria:
Inclusion Criteria:

* Single or multiple RT1, RT2 GR patient
* patients ≥18 years
* systemically healthy, full mouth plaque score, full mouth bleeding score ≤ 15% after phase I therapy
* clinical indication and/or patient request for recession coverage
* well motivated patients, maintaining oral hygiene throughout study

Exclusion Criteria:

* Pregnant or lactating women
* Smokers' patients
* Teeth with cervical restorations/abrasion.
* Patients had a systemic condition affect blood components and healing
Treatment of Zollinger-Ellison Syndrome With Prevacid

The purpose of this study is to study the safety and efficacy of high dose Prevacid in the long-term treatment of patients who secrete abnormally large amounts of gastric acid.

The aim of this protocol is to study the medical management of acid hypersecretory states including Zollinger-Ellison using Prevacid. The immediate objective is to heal peptic ulcers and eliminate symptoms and in the long term to prevent relapse of symptoms, lesions and complications. Other objectives include observation of the efficacy in controlling gastric acid production and of the safety of high dose, long-term use of Prevacid.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with Zollinger-Ellison syndrome

Exclusion Criteria:

* Pregnant or lactating females
Anatomic Relationship Of the Popliteal Vessels In Open Wedge Osteotomy

The Aim Is To Study The Anatomic Relationship Of The Popliteal Vesseles In Two Types Of (OWHTO) Techniques (Monoplanar VS Biplanar) Which Provide More Safe Technique To The PV

Open wedge High tibial osteotomy (OWHTO) is a common surgical Procedure that is utilized to correct knee varus deformity and prevent development or advancement of medial compatment knee osteoarthritis.

By turning the mechanical weight-bearing axis to the lateral side it correct lower limb alignment,decrease medial compartment load,pain,arthritic changes, postpone the need for arthroplasty and allow cartilage regeneration.

Like any other surgical procedure (OWHTO) has its own complications.injury to the popliteal vessels (PV) is catastrophic and limb threatening compliation that had been reported with prevalence rate ranging from 0.4% to 1.7% PV runs close to the posterior tibial cortex it might be injured while taking osteotomy cut. To avoid this problem many studies with different tools done to define PV position and its relations to provide safe technique for osteotomy.

(OWHTO) has different methods: Monoplanar and Biplanar osteotomy are most popular,both techniques differ in cut level and shape.

In this study the investigators compare between the two methods (Monoplanar VS Biplanar) concerning their proximity and safety to the PV .

Our hypothesis is that there is increase in the distance between the PV and the posterior tibial cortex the more distal the osteotomy level.

Previous studies cadaveric or preoperative studies provide useful informations with some different results , to the best of our knowledge postoperative studies rarely reported in this subject , the investigators hope this study could provide valuable informations,recommend safer technique and improve surgical outcomes from this procedure.

Eligibility Criteria:
Inclusion Criteria:

* age 30-60
* BMI less than 30
* isolated medial compartment OA
* mild to moderate degree OA Grade 2 to 3 according to kellgren\&Lawrence classification
* near normal lateral and patellofemoral compartment
* intact lateral meniscus
* varus malalignment less than 15 degree
* functional range of motion

Exclusion Criteria:

* inflammatory arthritis
* post traumatic arthritis
* patients with previous peripheral arterial injury
* disease or prior insertion of metallic stent in the PV
* patient allergic to contrast agent
* patient with renal impairement
* Patients who refuse to participate in the study
* Patients who are not available for follow up
NEurocontrolled BIdirectional Artificial Upper Limb and Hand prosthesiS

The NEBIAS ("NEurocontrolled BIdirectional Artificial upper limb and hand prosthesiS") proposal aims at developing and clinically evaluating (in selected amputees) a neuro-controlled upper limb prosthesis intuitively controlled and felt by the amputee as the natural one. This will be possible by means of a novel neural interface able to provide a stable and very selective connection with the nervous system. This goal will be achieved by combining microtechnology and material science and will allow, on one side, recording of the motor-related signals governing the actions of the amputated hand/arm for the motion control of a mechanical prosthesis, and on the other providing sensory feedback from tactile and kinesthetic sensors through neuromorphic stimulation of the adequate afferent pathway within the residual limb. The NEBIAS proposal is also aimed at finding out the 'language' intrinsically linking central nervous system with peripheral nerve signals in order to govern simple and complex hand/fingers movements. To reach this goal, a variety of techniques exploring brain and nerve functions will be assembled and integrated; this includes the analysis of electromagnetic brain and nerve signals, as well as of movement-related changes in brain's blood flow/metabolism.


Eligibility Criteria:
Inclusion Criteria:

* Adult man or woman \>18 yrs and \< 71 yrs.
* Transradial amputation or Congenital Hand Hypoplasia
* Amputation in the chronic stable phase
* Good functionality of muscles of the stump
* Absence of severe stump pain (VAS\<3)

Exclusion Criteria:

* Cognitive impairment
* Current or prior psychological impairments: Major personality disturbance (i.e. borderline, antisocial), Major depression, Bipolar I
* Pregnancy
* History of or active substance abuse disorder
* Acquired brain injury with residual impairment
* Intellectual Disability (IQ \< 70)
* Prior neurological or musculo-skeletal disease
* Current or prior dermatological conditions
* Excessive sensitivity to electrical stimulation (people afraid of electrical stimulation or pain)
* Persons with other diseases that may affect the function of the nervous system. (Diabetes, HIV, Renal Failure)
* Persons with pacemakers
* People affected by autoimmune and chronic infective diseases in treatment with immunosuppressive drugs
Safety Evaluation of Advantage Anti-Caries Varnish

The purpose of the study is to confirm the safety of Advantage Anti-Caries Varnish.

This is an open-label Phase 1 study. The active ingredients are Povidone Iodine and Sodium Fluoride \[Therametrics Technologies, Inc, Noblesville, IN, USA\]. The oral soft tissues and teeth of the children will be examined and the test varnish to the teeth. The child will be re-examined at 24-48 hours for the presence of adverse oral soft tissue changes. At the follow-up, a qualified dental provider will ask questions focused on adverse events.

Eligibility Criteria:
Inclusion Criteria:

* Healthy

Exclusion Criteria:

* Weight less than 15 kg or hypersensitivity to iodine
Is There an Allergy to Pure Metallic Gold Microparticles?

The investigators hypothesize gold is inert and thereby there is no pure-gold allergy. The primary aim of this study is to measure the prevalence of allergy to metallic pure gold microparticles and allergy to GSTS.

TRUE test panel which includes gold sodium thiosulphate (GSTS), 1 % w/v in petrolatum, and gold microparticles, 20-micron diameter, 1 % w/v in petrolatum, will be added added to the baseline series. It will be applied to the upper back of healthy adults in aluminum Finn Chamber for 48 hours. Clinical evaluation will be performed 24 hours after removal the test according to standard procedures for evaluation of epi-cutaneous challenging (Johansen 2015).

Eligibility Criteria:
Inclusion Criteria:

* Patients with chronic dermatitis

Exclusion Criteria:

* age \< 18