cyrilzakka/clinical-trials huggingface dataset:
Exploring the Distribution Patterns and Infrared Characteristics of Force-sensitive Acupoints in Different Lumbar Nerve Segments in Patients With LDH Based on "Press Quickly" Theory

Utilizing the "responsive acupoint palpation" technique and infrared thermography, we investigated the distribution patterns of pressure-sensitive acupoints across different lumbar spinal segments in patients with lumbar disc herniation (LDH). Methodology: The Finger TPS tactile pressure measurement system was employed to conduct sensitivity examinations on the acupoints of the L1\~L5 lumbar spine in 80 LDH patients (Group 1) and 80 healthy individuals (Group 2), applying a standardized force of 60N. When a sensation of comfort was elicited, the points were marked on a human cutaneous nerve segment map. We then utilized infrared thermography to collect and compare the temperature differences of the top 10 most frequently responsive acupoint areas in the experimental group against those in the control group.


Eligibility Criteria:
Inclusion Criteria:

* Age range of 18 to 65 years, regardless of gender.
* Radiological confirmation of central type L4\~L5 intervertebral disc herniation.
* Meeting the diagnostic criteria for lumbar disc herniation, primarily manifesting as lower back pain, radicular pain, and numbness or weakness in the lower limbs, with imaging findings consistent with neurological localization.
* Patients in the non-acute phase of mild to moderate pain and functional impairment (onset more than 2 weeks ago), with a visual analog scale (VAS) score greater than 4 points and a Japanese Orthopaedic Association (JOA) score less than 15 points.
* No consumption of analgesics, neurotrophic drugs, or sedatives, and no systemic treatment in the past week.
* Willing participants in the study who have signed an informed consent form.

Exclusion Criteria:

* Concomitant internist and gynecological diseases that can cause lower back pain, such as nephritis, urinary tract stones, gynecological inflammations, and uterine pathologies.
* Individuals with severe primary diseases of the cardiovascular, cerebrovascular, liver, kidney, etc.
* Patients with neurosis or psychiatric disorders, or those with a history of cranial trauma or coma.
* Patients with primary or ankylosing sciatica.
* Individuals with concomitant lumbar spondylolisthesis.
* Patients with lumbar spine tumors or tuberculosis.
* Individuals with consciousness disorders, severe impairments in vision, hearing, or speech, or any other condition that prevents the completion of a health assessment.
Cardiac Structure, Function, and Clinical Manifestations in MINOCA

The purpose of this study is to improve the differential diagnosis and clinical outcomes of acute coronary syndrome with non-obstructive coronary arteries, to investigate the relationship between the structural and functional state of the heart and the clinical course of the disease.

Up to 14% of patients with acute myocardial infarction do not have obstructive changes in the coronary arteries according to invasive coronary angiography (defined as stenosis of \> 50% by ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation, 2017). Elevation of highly sensitive Troponin I is a marker of damage to cardiomyocytes, but it is not an underlying mechanism of myocardial damage. Forty patients with acute coronary syndrome are planned to be enrolled in the non-randomized open controlled study. On admission, patients will receive the standard treatment for ACS with and without ST elevation. Within 24 hours, they will undergo diagnostic coronary angiography. In case of nonstenotic atherosclerosis of coronary arteries (normal / stenosis \< 50%), patients are planned for cardiac contrast MRI, which will identify both ischemic and non-ischemic causes of acute coronary syndrome; MSCT will be performed to study the coronary arteries and the structure of atherosclerotic plaques; scintigraphy of the myocardium will be performed to characterize the perfusion defect. The frequencies of carrying the genetic alleles associated with the factors that predispose to thrombosis will be studied. Significance of these alleles in the development of thrombosis in acute myocardial infarction will be identified. The profiles of proinflammatory and anti-inflammatory response markers will be determined. Significance of these profiles in the development of acute myocardial infarction in patients with non-obstructive coronary atherosclerosis will be determined in comparison with control group. At one-year follow up, structural and functional characteristics of the heart will be studied again to assess dynamic changes in cardiac state. At one-year follow up, repeated studies will be perform to dynamically assess the structural and functional state of the heart.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years at time of enrolment (18 years and older)
* Patients with ACS with and without ST-segment elevation who underwent coronary angiography within 24 h after onset of the disease
* High cardiovascular risk by GRACE Risk Score
* The absence of obstructive coronary atherosclerosis (normal coronary artery / plaques \<50%) is based on the results of coronary angiography
* Sinus rhythm on electrocardiogram
* Written informed consent to participate in research

Exclusion Criteria:

* Patients previously undergone endovascular / surgical revascularization of coronary artery
* Severe comorbidity
* Severe renal failure (eGFR \< 30)
* Patients with cardiac pacing and claustrophobia
* Contacts / Locations
Observational, Postmarketing Surveillance Study of Spinraza Injection (Nusinersen Sodium)

The primary objective is to evaluate the safety of nusinersen sodium injection in the postmarketing setting in Korea. The secondary objective is to evaluate the effectiveness of nusinersen sodium injection in the postmarketing setting in Korea.


Eligibility Criteria:
Key Inclusion Criteria:

* Currently receiving or about to initiate treatment with commercial Spinraza in the postmarketing setting
* Genetic documentation of 5q-linked SMA

Key Exclusion Criteria:

* Hypersensitivity to the active substance or any of the excipients of Spinraza
* Ongoing participation or participation within 6 months or 5 half-lives of the agent (whichever is longer) of enrollment in other interventional clinical trials for the treatment of SMA
* Inability to comply with study requirements

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Positive Affect Promotion to Empower Optimal Adherence to HIV Therapy

This study assesses the feasibility and acceptability of the APPEAL program, a 3-session intervention designed to promote positive affect among men and women living with HIV infection. Forty participants will be randomly assigned to receive the APPEAL program, and another 40 will receive standard of care. All participants will complete self-reported assessments at baseline and at 3 and 6 months, and will have their HIV antiretroviral medication adherence monitored as part of study participation.

There is strong reason to expand the scope of current adherence programs to include consideration of a group of health protective variables known as 'psychosocial assets'. These assets include cognitive factors, such as optimism, emotional factors, such as positive affect, and positive social relationships. Increased psychosocial assets such as positive affect are associated with reduced morbidity and mortality, slower slower HIV progression, and reduced burden of depression symptoms. However, there has been limited translation of positive affect interventions to support patient self-management. In this study, we extend previous research on positive affect and adherence through the APPEAL program. The Affect, Promoting Positive Engagement, and Adherence for Life (APPEAL) program is an intervention that combines positive affect approaches to promote adherence in patients who have suboptimal adherence. We seek to implement the program, assess its feasibility, and describe associations with theoretically derived mechanisms of change, including positive affect.

Eligibility Criteria:
Inclusion Criteria:

* Receiving HIV care at site of recruitment
* Prescribed an HIV antiretroviral regimen
* HIV RNA viral load less than 200 copies/mL in last six months

Exclusion Criteria:

* Unable to communicate in English
* Prior participation in formative components of the study
* Plans to move outside of New York City in next six months
* Has cognitive impairment that would limit ability to provide informed consent
Sensorimotor Dysfunction of Individuals With Neck Pain

Systematically assessing the proprioception-coordination capacity of the spine in patients with different severity of neck disability could reveal how the dysfunction of the sensory-motor system was progressed. From the result of the research, a prospective study would be designed to test the hypotheses that described the mechanism of neck pain based on the results to the present study.

The purposes of this research were to investigate the effect of age and chronic neck pain on cervical proprioception, the change of ultrasonographic (USD) patterns in deep neck muscle and superficial neck muscles. The hypotheses of this research included: 1) the alteration of neck proprioception is determined predominantly by the changed activation deep neck muscles and superficial neck muscles. 2) Age factor contributes to the alteration of cervicocephalic sensibility, USD pattern of deep and superficial muscles. 3) Chronic pain contributes to the alteration of cervicocephalic sensibility, USD pattern of deep and superficial muscles.

Neck proprioception is measured by an ultrasound-based coordinate measuring system (CMS 70P, Zebris, Germany) by asking the subjects to performed head repositioning to the neutral head position or to a target position in three cardinal plane. These repositioning error expressed in root mean square errors could represent the craniocervical kinesthetic sensibility. The change of muscle thickness (mm) of the superficial (Trapezium, Splenius) and deep (semispinalis cervicis and multifidus) dorsal neck muscle is measured by a real-time ultrasonographic scanner (HDI 5000, ATL Ultrasound, USA). Image is obtained for each cervical level, and the thickness of the muscle is identified manually using a custom-written C++ computer graphic program. The measurements of pain intensity and pain frequency are modified from the symptoms questionnaire to indicate the intensity, location, frequency and duration of pain and disability of the subjects. The age and pain effects for each independent variables measured in patients with chronic neck pain (pain: intensity, location, frequency, and duration, NDI), will be tested with the General Linear Model (GLM; age and pain factors). The confounding factors such as gender, range of motion, body height and weight are controlled in the regression model.

Eligibility Criteria:
Inclusion Criteria:

* posterior neck pain with duration over 3 months

Exclusion Criteria:

* surgery on cervical spine
* achilosing spondylitis
* diabetes mellitus
* traumatic injury directly over head and neck area
* progressing neurological disease
Study of Sunobinop on Craving in Alcohol Use Disorder

The purpose of this study is to evaluate the efficacy of sunobinop compared to placebo on alcohol craving in subjects with moderate to severe alcohol use disorder and these subjects are seeking treatment.


Eligibility Criteria:
Key Inclusion Criteria include:

* Male and female age ≥18 years.
* Diagnosis of moderate or severe alcohol use disorder.
* Currently seeking treatment for alcohol use disorder.
* Has 4 or more heavy drinking days (HDD) in each of the 4 weeks prior to baseline visit.

Key Exclusion Criteria include:

* Subjects that meet current DSM-5 criteria for moderate or severe substance use disorder other than alcohol and nicotine.

Other protocol-specific inclusion and exclusion criteria may apply.
Adherence to Otezla

Most people with psoriasis have very limited disease, yet that disease may still have a large impact on their lives. While limited psoriasis may be amenable to topical treatment, patients are exceptionally poorly adherent to topical treatment, especially over the long run.

Psoriasis patients prefer oral treatments and are more adherent to orals than to topicals, but adherence to oral treatment of psoriasis may still be limited, compromising treatment outcomes. How well the medication works in the patients who take treatment regularly is not well characterized.

Eligibility Criteria:
Inclusion Criteria:

* Adult 18 years or older
* Diagnosis of mild psoriasis with Otezla recommendation
* Non-pregnant
* English speaking

Exclusion Criteria:

* Under 18 years of age
* Not diagnosis of mild psoriasis
* Pregnant
* Non-English speaking
Effect Of High-Intensity Focused Ultrasound On Abdominal Skin Laxity Post Sleeve Gastrectomy

The purpose of the study is to evaluate the therapeutic effect of High intensity focused ultrasound in treatment of abdominal skin laxity post sleeve gastrectomy.

Lax skin is a common consequence of bariatric weight loss, and it may require one or more plastic interventions.

This study carried out to investigate the effectiveness of High-intensity focused ultrasound (HIFU) in treatment of abdominal skin laxity post sleeve gastrectomy.

Eligibility Criteria:
Inclusion Criteria:

The subject selection will be according to the following criteria:

* Age range between 30-45 years.
* Female patients will participate in the study.
* All patients will have post sleeve gastrectomy abdominal skin laxity mild to moderate degree according to skin laxity scale Randomized images were evaluated by three clinical specialists for the degree of skin laxity (0-3 scale; 0 = no laxity, 1 = mild, 2 = moderate, 3 = severe).
* All patients enrolled to the study will have their informed consent.

Exclusion Criteria:

The potential participants will be excluded if they meet one of the following criteria:

* Age more than 45 years or less than 30 years.
* Patients have acute viral diseases, acute tuberculosis, mental disorders
* Older people with more extensive photo-aging, severe skin laxity.
* Open skin lesions at the target area.
* Severe or cystic acne.
* Metallic implants in the treatment area.
* Genetic disease
* Skin infectious diseases.
* Sociological diseases.
* Pregnant.
Herpes Zoster Prevalence in Frailty Consultations

Herpes zoster and post herpetic pain are common causes of morbidity in the elderly. Herpes zoster is caused by reactivation of the virus varicella zoster of latent infection in sensory ganglia. The acute phase of herpes zoster usually occurs ≤ 30 days after rash onset. However, the most common complication of herpes zoster is the post herpetic pain, which is usually defined as a persistent chronic pain for ≥ 3 months after rash onset. The risk of herpes zoster in life is 25-30%, but this figure rises to 50% among those aged ≥ 85 years. Similarly, the risk of experiencing post herpetic pain increases with age.

Despite treatment with antiviral drugs, post herpetic pain has been reported in 10-20% of all patients with herpes zoster, but its incidence increases significantly in elderly patients over 60 years. It can be particularly harmful when it occurs on a particular field, elderly multiple pathologies, fragile and with multiple treatment. In this context of decompensation "cascade" greatly exacerbate the impact of the initial local disease. Ophthalmologic involvement is rare but clinically worrisome and generates significant costs.

The annual incidence of herpes zoster in France is estimated at 3.4-4.4 cases per 1 000 people in the general population regardless of the history of Herpes zoster. The highest incidence concerns people aged 65 and over with an incidence estimated between 8-10 cases per 1 000 people, representing more than 100 000 cases of herpes zoster.

Due to the increasing number of older people in the French population, the number of herpes zoster should thus parallel increase in the coming years. The risk factors are well identified for certain (age, ethnicity ...) but for others less well defined (diabetes, composite criteria multiple pathologies ...) and insufficient to explain why some people exposed to the same risk factors will not make shingles during their lifetime.

Post herpetic pain is the leading complication of this disease with a higher risk in patients over 70 years causing a risk of autonomy loss. In fact, besides the disability of the pain itself, post herpetic pain often requires a combination of high-dose painkillers. The main therapeutic classes of analgesics used are antiepileptic in high doses (Gabapentin, Pregabalin), tricyclic antidepressants (amitriptyline), or opiates. The prevention with herpes zoster vaccine showed a reduction by 2 of risk and could therefore prevent addiction caused by induced recurrences of herpes zoster and treatment of post herpetic pain.

A study of importance is needed to further define the prevalence of this disease in the population of frail elderly and to identify factors associated with the occurrence of herpes zoster, post herpetic pain and ophthalmic zoster.

Eligibility Criteria:
Inclusion Criteria:

* Patients consulting at the daily hospital of fragility and dependence prevention during inclusion period

Exclusion Criteria:

* Patients not consulting daily hospital of fragility and dependence prevention
* Patients consulting outside the inclusion period dates
* Patients vaccinated against zoster
Shortened Depression Assessment Study

Participants will be asked to fill out an online questionnaire about their demographics information and all 42 items from the Depression Anxiety Stress Scale (DASS-42). A series of machine learning techniques will be applied to the dataset to develop a shortened assessment using the most important demographics and DASS-42 items from the original questionnaire, to predict depression levels indicated by DASS-42.

Clinical depression affects 5-10% of the world population each year and is a serious mental health issue globally. There are many traditional psychological scales that assess levels of depression in adults, where their items are often redundant in the information they carry, and their scoring is not necessarily linear to the item scores. Thus, machine learning techniques can help find the redundancy in the items, as well as the nonlinear relationship between the item scores and the final prediction. Using the Depression Anxiety Stress Scale 42 (DASS-42) as the basis, participants will be asked to fill out an online questionnaire about their demographics information (age, gender, country of residence, race, etc.) and all 42 items of DASS-42 to provide a dataset for this study. Feature selection techniques such as MRMR and Gini feature importance were applied to identify the most important features in the dataset. Then, using machine learning methods such as Logistic Regression, XGBoost, and Ensemble models, models will be fitted on the most important features to develop a shortened depression scale (7-9 items consisting of demographics items and DASS items) that accurately predicted the levels of depression (as measured by the AUC, ROC and F1 scores.

Eligibility Criteria:
Inclusion Criteria:

* Adults aged 18 and above
* Must be able to read English
* Must have access to the Internet worldwide

Exclusion Criteria:

* Children aged 17 and under
* Persons who cannot read English
* Persons that do not have access to Internet
Performance of the Travoprost Intraocular Implant

To evaluate the performance of the Travoprost Intracameral Implant by determining residual drug in explanted implants of the Travoprost Intracameral Implant and by determining aqueous humor concentrations of travoprost free acid at specified timepoints post administration through 24 months


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of either open angle glaucoma (i.e. primary, pseudoexfoliation, or pigmentary glaucoma) or ocular hypertenson
* Zero to three topical intraocular pressure lowering medications at the time of Visit 1 (Screening) exam.
* Best spectacle corrected visual acuity of 16 letters or more correctly read at 4 meters or better in each eye.
* Open angle as defined by Shaffer grade ≥ 3 at slit-lamp at the planned implantation site

Exclusion Criteria:

* Traumatic, uveitic, neovascular, or angle-closure glaucoma; or glaucoma associated with vascular disorders
* Active ocular inflammation, infection or edema
* Clinically significant dystrophy (e.g., bullous keratopathy, Fuch's dystrophy) or clinically significant guttata
Long-term Open-Label Safety Study to Evaluate EN3409

The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended period of time.


Eligibility Criteria:
Inclusion Criteria:

* Female subjects who are practicing abstinence or using a medically acceptable form of contraception or have been postmenopausal, biologically sterile, or surgically sterile for more than 1 year
* Male subjects who are practicing abstinence, surgically sterile, or are using a medically acceptable form of contraception
* De Novo subject with a clinical diagnosis of moderate to severe noncancer-related CP (eg, CLBP, OA, neuropathic pain) for ≥ 3 months
* De Novo subject that is treating their CP with a stable daily maintenance dose of ATC opioid analgesic medication equivalent to ≥ 60 mg and ≤ 160 mg Morphine Sulfate Equivalent (MSE) per day for ≥ 4 weeks
* Stable health, as determined by the Principal Investigator
* Subject is willing and able to comply with all protocol required visits and assessments
* Rollover subject who has completed the 12-week Double-blind Treatment Phase in the EN3409-307/308 clinical study

Exclusion Criteria:

* A history or current evidence of any clinically significant disorder or any other condition, which in the opinion of the investigator, would jeopardize the safety of the subject or impact the validity of the study results
* Females who are pregnant, breastfeeding, or plan to become pregnant during the study
* Current cancer-related pain or received chemotherapy within 6 months of screening
* Subjects receiving opioid analgesic medication \< 60 mg MSE per day within 28 days of screening
* De novo subjects receiving opioid analgesic medication at doses of \> 160 mg MSE per day within 28 days of screening
* Subjects with a history of other chronic painful conditions, other than the index CP condition, which require frequent analgesic medication
* Reflex sympathetic dystrophy or causalgia (complex regional pain syndrome), acute spinal cord compression, cauda equina compression, acute nerve root compression, meningitis, or discitis
* History of allergy or contraindications to any opioid or acetaminophen
* Surgical procedure for relief of pain within 6 months, or nerve/plexus block within 28 days of screening
* Hypokalemia or clinically unstable cardiac disease
* Moderate to severe hepatic impairment
* Moderate to severe renal impairment
* Current or past history of alcohol or substance
* Positive urine toxicology screen for drugs of abuse
* History of abnormalities on physical exam, vital signs, ECG, or lab values