cyrilzakka/clinical-trials huggingface dataset:
Scapular Upward Rotation Exercises for Subjects With Deperessed Scapular Alignment

It was hypothesized that:

There is no statistical significant effects of a scapular vupward rotation exercise (SURE) on scapular alignment in subjects with scapular downward rotation syndrome (SDRS).

There is no statistical significant effects a scapular upward rotation exercise (SURE) on mechanosensitivity of the upper limb peripheral nervous system in a depressed scapular alignment subjects.

There is no statistical significant effects a scapular upward rotation exercise (SURE) on pressure Pain Threshold in a depressed scapular alignment subjects.

There is no statistical significant effects a scapular upward rotation exercise (SURE)on Strenght Duration Curve measurement in a depressed scapular alignment subjects.

This study was conducted to investigate the effects of scapular upward rotation exercises on strength duration curve and pressure pain threshold (PPT) in subjects with scapular downward rotation syndrome.

Thirty subjects with age range of 18 to 30 years with scapular downward rotation were recruited in this study.

Thirty subjects of both gender with scapular downward rotation were recruited in this study.

All recruited subjects were examined to exclude defined pathological conditions.

All subjects were assessed by screening examination for downward rotation of scapula.

Pressure pain threshold was measured using pressure algometer. Mechanosensitivity of neural tissue was measured using neurodynamic test. Pain was measured using strength-duration (SD) curve. Treatment program consisted of 3 sessions/week, for 6 weeks. All measurements were taken pre and post the treatment period.

Eligibility Criteria:
Inclusion Criteria:

* University population were screened for subjects with scapular downward rotation, those who met the following criteria was recruited in this study. The inclusion criteria for subject selection in this study was based on the literature (Caldwell et al., 2007; Ha et al., 2011) which included:

  1. The scapula was downwardly rotated by visual appraisal.We examined the root of spine of scapulae (superior angle) and inferior angle of scapulae. If scapulae was downwardly rotated, inferior angle closer to spine than root of spine of scapulae (superior angle).
  2. The clavicle appeared to be horizontal or the acromioclavicular joint was lower than the sternoclavicular joint by visual appraisal.
  3. The vertebral borders of the scapula was less than 3 inches from the spine by tape measure.

Exclusion Criteria:

* Subject who has any of the following criteria was excluded from the study:

  1. Subjects with cervical spinal fractures.
  2. Neck-rotation ROM of \<20º.
  3. Radiating pain to an upper extremity.
  4. Scoliosis.
  5. Leg length discrepancy.
  6. A history of unresolved cancer.
  7. Diabetes Miletus.
  8. Polyneuropathy.
  9. Myofascial Pain Syndrome.
  10. Fibromyalgia.
Haptic Devices Impact on Laparoscopic Simulators

The study investigates the impact haptic devices have on reaching proficiency on a laparoscopic simulator as well as investigation if there is a difference in retention of the acquired skills.


Eligibility Criteria:
Inclusion Criteria:

* Must be a junior doctor working in a surgical department

Exclusion Criteria:

* Having performed any laparoscopic surgeries as primary surgeon
* Lack of Basic Danish on a conversational basis
Application of Ectoin Containing Lozenges (EHT02) in Patients With Acute, Viral Pharyngitis.

The goal of this non-interventional study is to investigate the safety, efficacy and tolerability of Ectoin Lozenges Honey Lemon (EHT02) compared to lozenges containing hyaluronic acid and islandic moss in the treatment of acute viral pharyngitis.

The current non-interventional study aims to investigate the efficacy and tolerability of Ectoin Lozenges Honey Lemon in patients suffering from acute viral pharyngitis. Participants receive treatments as part of routine medical care, and participants can choose one of two treatment options: a) Ectoin Lozenges Honey Lemon or b) lozenges containing hyaluronic acid and icelandic moss.

Efficacy will be studied by documentation of the following symptoms:

* pain on swallowing
* hoarseness
* urge to cough
* dry mouth and throat
* redness of oropharynx and larynx
* sore throat
* impairment of free breathing
* general feeling of illness

In parallel, participating patients will document their symptoms over the entire study duration in patient diaries.

The observation takes place over a period of seven days.

Eligibility Criteria:
Inclusion Criteria:

* patients with acute viral pharyngitis

Exclusion Criteria:

* patients with known intolerance to one of the substances used
* Pregnancy
* Surgical Procedures in the mouth and throat region prior to the study
* Bacterial Pharyngitis
* symptoms in the throat since more than 5 days
* Contraindications according to the instructions for use
Acute Effect of Instrument-Assisted Soft Tissue Mobilization on Hamstring Flexibility Via Fascial Chain

Instrument assisted soft tissue mobilization (IASTM) is one of the methods used to achieve fascial release. In this study, it will be examined whether there will be an increase in hamstring flexibility by releasing the superficial posterior fascial chain as a result of the IASTM technique to be applied over the triceps surae muscle and plantar fascia. Sociodemographic information of individuals who meet the inclusion criteria and volunteer to participate in the study will be obtained, and straight leg lift test and popliteal angle measurement will be performed with the digital inclinometer (Baseline Digital Inclinometer) to be provided within the scope of the project to measure hamstring flexibility. Then, IASTM will be applied to the triceps surae muscle and plantar fascia for 15 minutes. Measurements will be repeated after the application.


Eligibility Criteria:
Inclusion Criteria:

* Healthy individuals with a straight leg lift test less than 80° and a popliteal angle greater than 15° will be included in the study.

Exclusion Criteria:

* Individuals with a history of lower extremity fractures, lumbar disc herniation, acute pain, a history of lesion in the hamstring muscles at least 1 month before the study, knee or hip prosthesis, and those using drugs that may affect the measurements (e.g., muscle relaxants) will not be included in the study.
Efficacy of TopClosure(C)System in Healing Complicated Pacemaker Wounds

Patients receiving oral anticoagulation or anti-platelet therapy are at high risk of hematoma after device implantation. This study intends to examine the efficacy of the TopClosure(c) System in wound healing in these patients.


Eligibility Criteria:
Inclusion Criteria:

* Patients treated with anticoagulant therapy
* Patients treated with antiplatelet therapy

Exclusion Criteria:

* None
A Trial of SAMe for Treatment-Resistant Bipolar Depression

S-adenosyl-L-methionine (SAMe) is a dietary supplement with antidepressant properties. SAMe's mechanism of action remains unclear, but it appears to be distinct from that of conventional antidepressants. The purpose of this study is to examine the effect of these properties on the mood of bipolar subjects with persistent major depression that has been unresponsive to standard pharmacotherapy.

Depression in bipolar disorder is a significant source of disease-related debility; with bipolar individuals typically spending three fold as much time depressed as manic or hypomanic. Clinicians treating bipolar disorder often struggle to provide relief from depressive symptoms that are more often treatment resistant than in unipolar depression. To complicate matters further, the risk/benefit ratio of currently available antidepressants is a source of debate within the field of psychiatry.

S-adenosyl-L-methionine (SAMe) is a dietary supplement with well-established antidepressant properties. SAMe's mechanism of action remains unclear, but it appears to be distinct from that of conventional antidepressants. The purpose of this study is to examine the effect of these properties on the mood of bipolar subjects with persistent major depression that has been unresponsive to standard pharmacotherapy.

An unusual aspect of the current study design is the schedule of SAMe dosing. SAMe tablets will be administered intermittently and in steadily increasing dosages. The purpose of this gradual and intermittent dosage titration is to lessen the risk of antidepressant-induced mania by seeking the minimum effective oral dose of SAMe.

Eligibility Criteria:
Inclusion Criteria:

* bipolar disorder
* depressed for 3-12 months
* mood unresponsive to at least 2 treatments
* currently on mood stabilizer at therapeutic doses

Exclusion Criteria:

* history of mania while on adequate mood stabilizer
* rapid cycling bipolar disorder
* previous use of SAMe during current episode
* unstable medical illness including parkinson's disease
* methotrexate use
* pregnancy
* substance abuse/dependence
Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency

The purpose of this study is to determine if the supplement, Fisetin, can be used as a treatment option for common variable immunodeficiency (CVID) by comparing its efficacy to placebo.


Eligibility Criteria:
Inclusion Criteria:

* Patient must have received a diagnosis of CVID according to the international consensus document (ICON) at least 30 days before enrollment.
* Physician diagnosis of possible GLILD associated with CVID.
* IgA results.
* Female patient is either not of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile. (A negative pregnancy test for women whose menopausal status is determined by self-reported absence of menstrual periods in the past 12 months will be required within 72 hours prior to randomization).
* Patient must be able and willing to comply with the requirements of this study protocol.

Exclusion Criteria:

* Unable or unwilling to give informed consent.
* Presence of any condition that the Investigator or the subject's attending physician believes would put the subject at risk or would preclude the patient from successfully completing the trial.
* Pregnant and/or lactating. Women of childbearing potential (WCBP) must have a negative pregnancy test within 72 hours prior to randomization.

WCBP who are unwilling to abstain from sex or use an adequate method of contraception from the time of the first IP administration through 48 hours after the last IP administration.

* Men who are unwilling to abstain from sex with WCBP or use an adequate method of contraception from the time of the first IP administration through 48 hours after the last IP administration.
* Prisoners, institutionalized individuals, or others who may be considered vulnerable populations, such as individuals with dementia.
* Patient currently hospitalized or under immediate consideration for hospitalization.
* Current use of tobacco products or as per clinical judgement.
* Current excessive caffeine intake (400 mg or more per day).
Silastic Stent Study

Endoscopic skull base surgery is a relatively new procedure that is now a standard of care for surgeries at the base of the skull; however there are no studies that examine the healing process of the nasal lining with the use of silastic (silicone) stents (or splints) that might be placed at the time of surgery. While there is some evidence to suggest that the use of stents improves wound healing, the decision to use a stent or not is currently up to the preference of the surgeon. To investigate the impact of stents on post-surgical healing, the investigators at Vancouver General Hospital will compare patients undergoing trans-sphenoidal pituitary surgeries with septal flap reconstruction with the use of silastic stents to line the septal donor site, and compare their recovery to those who did not receive stents. The investigators hypothesize that the use of silastic stents in endonasal surgery increases the rate of mucosal healing, and better quality mucosal regeneration, and with no effect on the patients experience after surgery. In this randomized control trial the investigators aim to recruit 26 (13 in each arm) study participants. The primary outcome is to determine the effect of silastic stunting on healing of the naso-septal flap donor site. This objective will be achieved by assessment of endoscopic photographs of healing tissue and histologic assessment of healing tissues. The secondary outcome involves questionnaires that measure the patient's subjective nasal symptoms prior to and following endoscopic skull based surgery. Total time commitment for the study participant is about 4 months across 4 study visits (all of which are part of standard of care): the assessment visit, surgery, 4 weeks post-operative follow up visit and 12 week post-operative follow up visit.


Eligibility Criteria:
Inclusion Criteria:

* patients undergoing trans-sphenoidal endoscopic pituitary surgery at their first post-operative appointment

Exclusion Criteria:

* patients with inflammatory sinus conditions
* patients having undergone extensive skull base reconstructions
* patients having received previous radiotherapy
Epidemiology of Osteoarthritis (OA) Pain

Chronic pain, by definition, persists over long periods of time, but both sufferers of pain and their caregivers are aware that pain levels can fluctuate greatly over time. Being able to define pain variability and its underlying causes would be an important advance in our understanding of chronic pain, and would in turn lead to better approaches to the treatment of chronic pain. In this study, the investigators propose to evaluate in 60 people with chronic pain of the knee due to osteoarthritis over 3 months, collecting data regarding magnitude of pain, physical activity level, and medication status twice daily during this period of time. The investigators then will assess the variability in pain levels over time, the frequency of "flares" of osteoarthritis (OA) pain and their relationship to physical activity, medications, and clinical descriptors of the population, e.g., age, gender, body mass index (BMI). Additionally, evaluations will be made regarding temporal patterns of OA knee pain as well as assessment of subgroups of patients with the overall group being studied.


Eligibility Criteria:
Inclusion Criteria:

1. Men and women, age 40 years and above
2. Knee pain most days of the week for the past month
3. Diagnosis of knee OA
4. Meet ACR criteria for knee OA
5. No significant limitations in physical activity
6. Own and able to use a cellular phone capable of text messaging
7. Able to return for all clinic visits
8. Able to read and understand the informed consent document

Exclusion Criteria:

1. Use of a walker to ambulate or inability to ambulate (use of cane is allowed)
2. Other forms of arthritis
3. Other major causes of pain that could be expected to interfere with assessment of pain during this trial, e.g., recurrent migraine, back pain, fibromyalgia
4. Scheduled for and likely to need joint replacement surgery in the next 3 months
5. Any medical condition that in the judgment of the investigator would make the participant not suitable for the study
6. Living in a long-term care facility
A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer

The study consists of a Phase1b lead-in portion to determine the maximum tolerated dose (MTD) of OMP-59R5 in combination with nab-paclitaxel and gemcitabine followed by a Phase 2, multicenter, randomized, placebo-controlled portion to evaluate the efficacy and safety of OMP-59R5 in combination with nab-paclitaxel and gemcitabine in subjects with previously untreated stage IV pancreatic cancer.


Eligibility Criteria:
Inclusion Criteria:

Subjects must meet all of the following major inclusion criteria to be eligible for the study:

1. 18 years of age or older
2. Histologically or cytologically documented stage IV ductal adenocarcinoma of the pancreas.
3. Performance Status (ECOG) 0 or 1
4. FFPE tumor tissue from metastatic site(s
5. Adequate organ function
6. Written consent on an IRB/IEC-approved Informed Consent Form prior to any study-specific evaluation.
7. For women of child-bearing potential, negative serum pregnancy test at screening and use of physician-approved method of birth control from 30 days prior to the first study drug administration to 30 days following the last study drug administration.
8. Male subjects must be surgically sterile or must agree to use physician-approved contraception from 30 days prior to the first study drug administration to 30 days following the last study drug administration.

Exclusion Criteria:

Subjects who meet any of the following major exclusion criteria will not be eligible for participation in the study:

1. Neuroendocrine tumors (i.e., carcinoid, islet cell cancer) of the pancreas.
2. Known brain metastases.
3. Prior therapy, including systemic therapy, surgical resection or radiation for newly diagnosed stage IV pancreatic cancer.
4. Presence of any serious or unstable concomitant systemic disorder incompatible with the clinical study (e.g., substance abuse, uncontrolled intercurrent illness including active infection, arterial thrombosis, symptomatic pulmonary embolism).
5. Any disorder that would significantly compromise protocol compliance.
6. Prior non-pancreatic malignancy treated with chemotherapy. Prior malignancies treated with surgery and/or radiotherapy alone must be in remission ≥3 years. The following prior malignancies are allowable irrespective of when they occurred: in situ carcinoma of the cervix, in situ ductal breast cancer, low-grade local bladder cancer, and nonmelanotic skin cancer.
7. Known human immunodeficiency virus (HIV) infection.
8. Females who are pregnant or breastfeeding.
A Modified Esophagogastric Reconstruction Method After Laparoscopic Proximal Gastrectomy

The double-flap technique (DFT) is an effective digestive tract reconstruction method after proximal gastrectomy (PG) to reduce the incidence of postoperative reflux esophagitis. But its clinical application is restricted due to the technical complexity. Our surgical team devise a modified esophagogastric reconstructive method which we term the "arch-bridge-type" reconstruction based on the principle of DFT. The aim of this single-arm prospective study is to assess the safety and feasibility of the "arch-bridge-type" reconstruction after PG.

1. The lymphadenectomy is performed according to the Japanese Gastric Cancer Treatment Guidelines.
2. Transection of the esophagus is performed using a linear stapler 2cm away from the proximal end of the tumor.
3. Creating the seromuscular flap ("arch-bridge"):

(1) The stomach is resected by a linear stapling device. (2) A "匚" shaped seromuscularflap (3.0cm×4.0cm) is created utilizing electrocautery extracorporeally by dissecting submocosal and muscular layer of the anterior wall of the remnant stomach.

(3) The opening of the flap is interrupted sutured by 4-0 absorbable suture, then the "arch-bridge" is created.

4.The remnant stomach is then inserted into the abdominal cavity, and pneumoperitoneum is re-established to perform the intracorporeal anastomosis.

Eligibility Criteria:
Inclusion Criteria:

* histologically proven proximal gastric cancer or adenocarcinoma of esophagogastric junction
* diameter of the tumor less than 4cm
* ECOG performance status score ≤2
* no distant metastasis
* informed consent is signed

Exclusion Criteria:

* metastatic gastric cancer or metastatic adenocarcinoma of esophagogastric junction
* remnant gastric cancer
* patient requires emergency surgery
Screening for Acute Malnutrition

This project includes a pilot cluster-randomized trial of the efficacy of training caregivers to screen for acute malnutrition (AM) in children aged 6-59 months using mid-upper arm circumference (MUAC) in Burkina Faso. The pilot will be conducted to establish the feasibility of procedures and preliminary outcome data to inform the sample size calculations and design of a future longer-term, fully powered cluster-randomized trial. Forty communities enrolled in the Bill \& Melinda Gates Foundation-funded Child Health with Azithromycin Treatment (CHAT) trial will be randomly selected for this pilot and randomized to receive the caregiver training intervention or no additional intervention. All communities will continue to receive standard of care screening for AM according to national guidelines, which includes community-based screening for AM by community health workers using MUAC every 6 months. A baseline census will be conducted before randomization to enumerate the eligible population of caregivers and children 6-59 months old and measure MUAC. A final census with MUAC measurement will be conducted 6 months later (primary outcome). Data will be collected on all children presenting to the Centre de Santé et Promotion Sociale (CSPS) for malnutrition to track secondary outcomes.

During intervention training, we will also conduct a diagnostic accuracy study to evaluate the validity of caregiver screening by comparing the MUAC measurements of caregivers against the gold standard measurement of the experienced health personnel conducting the training. Also during training, intervention communities will be randomized to one of two training approaches: training by caregivers or training by health agents and adherence to the protocol during follow-up monitoring visits will be compared to determine effectiveness of training.


Eligibility Criteria:
Cluster level:

* Enrollment in the CHAT trial
* Location outside of the Health and Demographic Surveillance System (HDSS)
* Population size \< 2000 people
* Verbal consent of the village leader

Individual level:

* Residence in a village participating in the CHAT trial
* Caregiver or guardian of children aged 6-59 months (for intervention training)
* Age 6-59 months (for MUAC screening and some outcome assessments)
* Verbal consent from caregiver or guardian