cyrilzakka/clinical-trials huggingface dataset:
Effectiveness of Mat Pilates Exercises in Individuals With Chronic Nonspecific Low Back Pain

To analyze the effectiveness of mat Pilates compared to no intervention in individuals with chronic nonspecific low back pain.

There is evidence that exercises based on the Pilates method reduce pain in chronic nonspecific low back pain (CNLBP). However, is noticed the lack of studies that compare the effectiveness of mat Pilates to no intervention in the treatment of individual with CNLBP. Therefore, the main objective of the study is to analyze the effectiveness of mat Pilates compared to no intervention in patients with chronic nonspecific low back pain. It is a randomized controlled trial with two arms and double blinded (caregiver, assessor and outcome assessor), composed of 30 patients, aged between 18- 65 years (±22,47) of both sexes, diagnosed with chronic non-specific low back pain persisting for more than three months and pain intensity greater than 3 points in the Pain Numerical Rating Scale. The participants were randomly divided into two groups: Pilates Group (n = 15), intervention based on mat Pilates exercises, and Control Group (n =15) with no intervention. The mat Pilates group performed 16 sessions, twice a week in 60-minute duration each throughout eight weeks, whereas the control group participants kept usual cares until the end of the intervention. Both groups were evaluated before and after the program by a researcher who was unaware of the patients' allocation. The primary assessed outcomes: pain intensity (Pain numerical rating scale, and McGill questionnaire), quality of life (SF-36), and disability (Oswestry Low Back Pain Disability Questionnaire). In addition, the strength and muscle activation of transverse abdominal as secondary outcome assessed through the Stabilizer Pressure Biofeedback Unit test. As a result, the study infers that mat Pilates exercises have significantly improved all the evaluated outcomes. Thus, supporting clinical decisions for the treatment of chronic nonspecific low back pain.

Eligibility Criteria:
Inclusion Criteria:

* Complaining of non-specific low back pain for more than three months without radicular symptoms for a period exceeding 12 months.
* Pain intensity equal to or more than 3 points evaluated by the Pain Numerical Rating Scale in the last seven days.
* Eligibility to practice physical activity responding to the Physical Activity Readiness Questionnaire - PAR-Q

Exclusion Criteria:

* Degenerative or inflammatory pathologies of the spine,
* Acute crisis of pain in the shoulders, knees, ankles and spine
* Spinal tumors
* Recent surgery on the spine, lower and upper limbs
* Herniated disc
* Spondylolysis or spondylolisthesis
* Rheumatologic diseases
* Patients who are in labor dispute
* In treatment involving Pilates, physiotherapy or medication.
* Do not understand the writing and speaking Portuguese.
Treatment Resistance Related With Gene Expression Profile of Diffuse Large B-cell Lymphoma

The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.

1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay

   * Diffuse large B-cell lymphoma patients
   * Paraffin-embedded tissue
   * End points: Progression-free survival, overall survival
   * Statistics: Leave one-out method
2. Nano string assay for microRNA

   * Diffuse large B-cell lymphoma patients
   * Paraffin-embedded tissue
   * End points: Progression-free survival, overall survival
   * Statistics: Leave one-out method

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with diffuse large B-cell lymphoma
* Patients with tissue blocks available for study
* Patients with adequate medical records

Exclusion Criteria:

* Patients diagnosed with other subtypes of lymphoma
A Study to Evaluate the Safety, PK of GC2129A in Healthy Volunteers Under Fed Conditions

The purpose of this study is to evaluate the safety and pharmacokinetics of oral administration of GC2129A in fed conditions to healthy adult volunteers.

This study is an open-label, randomized, fasting, single-dose, 2-group, 2-period, crossover design to evaluate pharmacokinetics that are not affected by blinding. According to the order of administering the investigational drug for each period, 17 people are assigned to each of the two groups and administered.

For healthy subjects, each 17 subjects are assigned to each of the two groups(total 34 subjects). If the subject administrate GC2129A in the first period, the subject will be administrated reference drugs in the second period after washout(over 7 days). Conversely, if the subject administrate reference drugs in the first period, the subject will be administrated with GC2129A in the second period.

Eligibility Criteria:
Inclusion Criteria:

* A person who is 19 years of age or older at the time of a screening visit
* A person with a body mass index (BMI) of 18.0 kg/m2 or more and 30.0 kg/m2 or less with a weight of 50 kg or more (45 kg or more for women) during a screening visit
* A person who has no clinically significant congenital or chronic disease during a screening visit and has no pathological symptoms or findings as a result of internal examination

Exclusion Criteria:

* Persons with clinically significant diseases or history of the digestive system, cardiovascular system, endocrine system, respiratory system, blood and tumor, infectious disease, kidney and urinary reproductive system, mental and nervous system, musculoskeletal system, immune system, otolaryngology, skin system, and ophthalmology.
* A person who has a history of gastrointestinal surgery
* Those who have taken drug metabolism enzymes, such as barbiturate drugs, within one month of the first dose date or who have taken drugs that may interfere with this clinical trial within 10 days of the first dose date
* A person who participates in another clinical trial or biological equivalence test within six months of the first administration date
* A person who has donated whole blood within 8 weeks of the date of first administration, or has donated components within 2 weeks, or has received a blood transfusion within 4 weeks
* A person who is deemed unsuitable for participation in this clinical trial by the principle investigator(or the delegated sub-investigator) for reasons other than the above selection and exclusion criteria
* In the case of female volunteers, a pregnant woman or pregnant woman is suspected
Dual Site-dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Stroke Patients

The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) Single stimulation 1: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional inferior frontal cortex; 3) Single stimulation 2: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional supraorbital area.


Eligibility Criteria:
Inclusion Criteria:

* left hemisphere involved stroke patients
* patients diagnoses as post stroke aphasia

Exclusion Criteria:

* history of psychiatric disease
* patients with metal implants
* history of epilepsy
* pregnancy
* skin defect at the site of electrode attachment
Evaluation of Marginal Bone Loss and Associated Factors Around Ziacom Dental Implants With Different Prosthetic Connection

Dental implants may suffer from bone loss around them, particularly at the upper portion where the prosthesis starts. The connection between both parts of the tooth restoration is key for avoiding micromovement during chewing, bacterial contamination and initiation of bone loss. Thus, investigating factors related to this bone loss in different types of implant-prosthetic connections is key for promoting better use of available therapeutics devices. In this study, we will study marginal bone levels over time as well as bacterial contamination and inflammatory markers in the peri-implant sulcus around implants with connical connection and compare them with those obtained when using implants with internal hexagonal connection. The hypothesis is that bone loss will be higher in implants with hexagonal connection associated with a pathological microbiome in the sulcus that induces a higher inflammatory response.


Eligibility Criteria:
Inclusion Criteria:

* One missing tooth in the premolar or molar area with both opposing and adjacent teeth (mesial and distal).

Exclusion Criteria:

* One-stage bone augmentation.
* Uncontrolled type 1 or 2 diabetes (HgA1c\>8).
* Known auto-immune or inflammatory disease.
* Severe hematologic disorders, such as hemophilia or leukemia.
* Local or systemic infection that may compromise normal healing (e.g., extensive periapical pathology).
* Liver or kidney dysfunction/failure.
* Currently receiving cancer treatment or within 18 months from completion of radio- or chemotherapy.
* Long-term history of oral bisphosphonates use (i.e., 10 years or more).
* History of intravenous bisphosphonates.
* Long-term (\>3 months) history of antibiotics or drugs known to alter the inflammation and/or immunological system 3 months before inclusion.
* Severe osseous diseases (e.g., Paget disease of bone).
* Pregnant women or nursing mothers.
* Not able or not willing to follow instructions related to the study procedures.
Anisotropic Textile Braces for Adolescent Idiopathic Scoliosis

One of the most common types of 3-dimensional spinal deformities with unknown etiology in youths is adolescent idiopathic scoliosis (AIS). The spinal curvature increases as puberty progresses. Generally, rigid orthotic bracewear is prescribed as non-invasive treatment for moderate AIS if treatment begins early and the orthosis is worn with compliance. Obviously, teenage patients are reluctant to accept a rigid orthosis due to aesthetics and the physical constraint. Therefore, semi-rigid and flexible orthoses have been developed, but their efficacy is still controversial and there are other issues, such as high pain scores. There is clearly room for improvement. Therefore, a garment-type of bracewear will be designed and developed to correct spinal deformity, reduce the possibility of spinal curve progression, and satisfy the needs of the patients as well as take their psychological concerns into consideration.

The design of the anisotropic textile braces will provide different mechanisms with rigid, semi-rigid and flexible materials:

1. axial elongation through a close fit of the brace supported with textile composites on the lateral sides of the trunk,
2. 3-point pressure with push and counter-pushes through semi-rigid pads inserted inside the pocket lining,
3. pulling or compression to correct kyphosis or lordosis in the sagittal plane with elastic bands,
4. derotation between the pelvis and shoulders with uneven straps, and
5. an active mechanism with sensors added to the brace to maintain correct posture.

Eligibility Criteria:
Inclusion Criteria:

* Aged 10 to 14 years
* Diagnosis of AIS
* a Cobb's angle between 20 to 30 degrees
* a Risser grade of the iliac crest of ≤ 2
* Pre-menarche or post- menarche by no more than 1 year
* Ability to read and understand English or Chinese
* Physical and mental ability to adhere to anisotropic textile braces protocol

Exclusion Criteria:

* Contraindications for x-ray exposure
* Diagnosis of other musculoskeletal or developmental illness that might be responsible for the spinal curvature
* History of previous surgical or orthotic treatment for AIS
* Contraindications for pulmonary and/ or exercise tests
* Psychiatric disorders
* Recent trauma
* Recent traumatic (emotional) event
A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer

The primary hypothesis of this study is that regular topical oral application of Manuka Honey will reduce the severity and duration of oral mucositis in patients who are undergoing mucotoxic radiation therapy for cancer treatment.

Oral mucositis is a common side-effect of radiation therapy for many head and neck cancers, and can have a very severe impact on quality of life and nutritional status. At least42% of patients treated for head and neck cancers will develop grade 3 or 4 oral mucositis. Although there have been positive trials, no study has had overwhelming data to strongly support any one agent in the prevention or treatment of oral mucositis. A comprehensive review of the literature done in 2004 found only benzydamine (a topical nonsteroidal anti-inflammatory agent) to be beneficial as a palliative treatment for established mucositis. Management essentially consists of pain management, with topical and oral analgesics/anaesthetics and anti-inflammatory agents, and nutritional support, once mucositis is established. Despite the use of these agents, many patients still have severe mucositis, and there is great need for new treatments to reduce this distressing complication of cancer therapy.

Currently, the only standard "treatment" consists of an oral rinse of warm water, salt, and baking soda 4 times a day. This is only to maintain oral hygiene and does not have any impact on the severity or duration of the mucositis itself. Topical fluoride is applied at bedtime to reduce the caries risk. Basic oral care (brushing and flossing as tolerated) is recommended to maintain general mucosal health and to reduce the impact of oral microbial flora.

Study Objectives The primary objective of this study is to see if topical oral Manuka honey reduces the severity of mucositis in patients receiving radiation treatment for head and neck cancer. Secondary objectives are to assess the impact of any demonstrated improvement in mucositis on nutrition, symptom burden, quality of life, and radiotherapy treatment interruptions.

Eligibility Criteria:
Inclusion Criteria:

* Patients commencing radiation therapy of 50 Gy or higher with the dosage field affecting the oral mucosa unilaterally or bilaterally (minimum 3 observable sites affected).
* Patients willing and able to attend weekly assessments throughout their treatment, plus one week after completion of treatment.

Exclusion Criteria:

* Patients unable to understand the consent process (translators will be used if necessary so being English-speaking is not required).
* Patients unable to attend the follow-up visits
* Patients participating in other clinical trials which might affect the severity of mucositis
* Patients allergic to honey, multiple pollens, or to celery
Effects Of Horizontal Versus Vertical Plyometric Exercises On Agility, Speed And Power Among Rugby Players

Participating in rugby demands specialized skills that encompass explosive movements and diverse muscle actions at varying speeds. Attributes like strength, speed, jumping capability, and agility play crucial roles in executing fundamental rugby skills, including sudden changes of direction, acceleration, and deceleration. Previous research has substantiated the positive impacts of plyometric training in young athletes during the in-season period, indicating the significance of targeted training during this timeframe for sustaining or amplifying explosiveness. Moreover, there is supporting evidence that integrating plyometric training into a traditional rugby training regimen yields favorable outcomes, specifically benefiting speed, vertical jumping performance, and agility. To determine the effects of horizontal versus vertical plyometric exercises on agility, speed, and power among rugby players.

This randomized clinical trial, to be carried out in DHA Rugby Stadium, Lahore, will enlist participants aged 18 to 28, encompassing both males and females, with a minimum of 1 year of rugby experience. The study aims to investigate the impact of horizontal and vertical plyometric exercises on agility, speed, and power in rugby players. Participants will be randomly assigned to Group A, receiving horizontal plyometric exercises, or Group B, receiving vertical plyometric exercises. Evaluation will involve the Hexagon test for agility, the 20m Sprint test for speed, and Vertical jump assessment for power. The results aim to contribute substantiated insights into the pre and post effects of these plyometric exercises on rugby players. Data analysis will be conducted using IBM SPSS Statistics 26

To determine effects of horizontal versus vertical plyometric exercises on agility, speed, and power among rugby players.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-28
* Both genders
* Rugby Players (playing 2 to 3 days per week)

Exclusion Criteria:

* Players with any previous injury
* Any congenital disorder
* Not playing for more than 6 months
* Symptoms of coronary artery and pulmonary disease
The Effect of Exercise Training and Arch Supported Insoles on Balance and Vertical Jump Performance in Football Players With Foot Pronation Deformity

This study aims to investigate the effects of foot pronation exercises and arch support insoles on balance and vertical jump test in football players.

The study took place in FootBalance Turkey, which works on foot analysis and insoles.

30 professional football players with pronation who divided into two groups. The football players in the Experimental Group used insoles and also participated the foot core exercise program twice a week for 4 weeks duration. The football players in the Control Group just used the insoles.We used the FootBalance assessmnet system for insoles. Navicular Drop Test, Y Balance Test, Flamingo Testand Vertical Jump Test applied to evalute foot pronation, dynamic balance, static balance and jump performace respectively.

Eligibility Criteria:
Inclusion Criteria:

1. Voluntary participation in research
2. To be between the ages of 18-45
3. Overpronation foot ( navicular drop test over 10 mm and FootBalance device with visual display)
4. Professional football players at least 5 years

Exclusion Criteria:

1. History of surgery for musculoskeletal structures in both lower extremities
2. History of fracture in both lower extremities
3. Acute injury of the musculoskeletal structures of other joints of the lower extremity affecting joint function and integrity in the last 3 months
4. Have any other knee pathology
5. Balance or vestibular disorder
Pilot Study Comparing the Safety and Efficacy of Two Dosing Regimens of TP-03 for the Treatment of MGD

The purpose of this study is to compare the safety and efficacy of TP-03, 0.25%, an eyedrop, BID vs TID dosing regimens for the treatment of meibomian gland dysfunction in patients with Demodex lid infestation.

This Phase 2a study is a randomized, two-arm, double-masked, multicenter, parallel pilot study to compare the safety and efficacy of two dosing regimens of TP-03, BID vs TID, for the treatment of meibomian gland dysfunction in patients with Demodex lid infestation. The primary objective of the study is to assess the safety and efficacy of two dosing regimens of TP-03, 0.25% from Day 1 to Day 85 in adult participants with meibomian gland dysfunction in the presence of Demodex infestation. Efficacy will be determined by assessing lower lid meibomian gland secretion, lid margin erythema, bulbar redness, tear breakup time, ocular surface staining, and dry eye symptoms. Safety will be determined by assessing adverse effects related to the treatment as well as evaluating any changes in visual acuity and slit lamp biomicroscopy from baseline.

Eligibility Criteria:
Inclusion Criteria:

* Be willing to sign the informed consent and deemed capable of complying with the requirements of the study protocol
* Meets all of the following criteria in at least one eye: have more than 10 lashes with collarettes present on the upper lid; have the presence of one or more mites in the upper and lower lids; have evidence of meibomian gland dysfunction; have at least mild erythema of the lower lid; have a tear breakup time of less than 10 seconds; and have intact partial to full meibomian glands in at least 33% of the total meibomian gland area of the lower lid

Exclusion Criteria:

* Have used lid hygiene products within 7 days of Day 1 or unwilling to forego the use of lid hygiene products during the study
* Have used systemic antihistamines within 30 days of Day 1
* Have used artificial eyelashes, eyelash extensions or had other cosmetic eyelash or eyelid procedures within 7 days of Day 1 or be unwilling to forego their use during the study
* Contact lens wear within 7 days of Day 1 or unwilling to forego contact lens wear for the duration of the study
* Be pregnant or lactating at Day 1
Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia

A randomized control trial examining the relationship between changes in hand function and brain plasticity following intensive therapy. Two treatment approaches are used: constraint-induced movement therapy (CIMT) or Hand-Arm Bimanual Intensive Therapy (HABIT). The protocols have been developed at TC Columbia University to be child friendly and draw upon our extensive experience with constraint-induced movement therapy in children with cerebral palsy. Our center has been providing interventions camps for children with cerebral palsy since 1998. The interventions are performed in a 15 day day-camp setting with several children and at least one interventionist per child. The aim of the intervention is to improve the use of the affected hand and quality of overall movement in a fun, social setting. PARTICIPATION IS FREE. Please check out our website for more information: http://www.tc.edu/centers/cit/

Constraint-induced Movement Therapy and Bimanual training are motor-learning based approaches to engage children in fun activities. This study looks at what areas of the brain are responsible for recovery after intensive training. We are trying to understand how the brain responds to movement training and hope that in the future we can develop new treatments for hemiplegia based on what we learn about the brain in this study.

To study the areas of the brain we will use Magnetic Resonance Imaging (MRI) to take pictures of the brain and Transcranial Magnetic Stimulation (TMS) to determine parts of the brain involved in using the hand. TMS uses a brief magnetic field over the scalp by using a wand that looks like a figure 8. The wand can make brief magnetic fields over a series of spots on your child's head to activate the brain cells under the wand. Non-invasive, single pulse TMS will be used in this study, which is considered minimal risk and tolerable to children. If your child has a recurrent history of seizures after two years of age, he/she might not qualify.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of unilateral cerebral palsy

Exclusion Criteria:

* Current medical illness unrelated to CP
* Seizure disorder
* Current use of medications know to lower the seizure threshold
* Metallic object(s) in body, other than dental fillings
* Pregnancy
* Claustrophobia