cyrilzakka/clinical-trials huggingface dataset:
RELATIONSHIP BETWEEN FORWARD HEAD POSTURE and HAMSTRING TIGHTNESS

The purpose of this study will be to investigate:

1. Relationship between forward head posture and hamstring tightness in young adults
2. The gender specific effect (female versus male) on the relationship between forward head posture and hamstring tightness in young adults

Forward head posture imposes approximately 3.6 times more pressure on the neck than proper posture, and the prolonged burden of supporting the increased head weight can potentially cause neck pain, fatigue, and chronic musculoskeletal disorders. Hamstring tightness can cause posterior pelvic tilt, which leads to decreased lordosis of lumbar spine and resulting in LBP. Hamstring tightness can contribute to various issues, including muscle strains,loss of lumbar spine curvature, sacroiliac joint disorders, and plantar fasciitis. These problems primarily arise due to misalignment of the body and imbalanced force distribution between muscles and joints. Hamstring and sub-occipital muscles are connected by a neural system and sub-occipital muscles pass through the dura mater. this is called superficial back line (SBL), which connects the lower extremities, trunk, neck, and head protects the body's entire posterior surface and provides an important function of up-righting the body. There is still lack of research work about the relationship between FHP and hamstring muscle tightness and the gender-specific effect (female versus male) on the relationship between FHP and hamstring tightness in young adults.

Eligibility Criteria:
Inclusion Criteria:

* Both genders were included, with an age ranged between 18 and 25 years old.
* Participants with a CVA equal to or less than 49° were included (Haytham M. Elhafez, 2023).
* Body mass index was between 18 and 25 kg. /m2 (Haytham M. Elhafez, 2023).

Exclusion Criteria:

* Systemic disease
* History of hamstring injury within the last 2 years
* Previous knee injury
* Fracture in the spine or lower limb
* Spinal or lower limb surgery
* Pregnancy
* Congenital deformity
* Leg length discrepancy more than 2cm
* Acute spasm of hamstring muscles
* Neuromuscular disorders of the lower extremity, like stroke, muscular dystrophy and peripheral neuropathy
* History of any malignancy or infectious disease
* Spinal or limb deformities
Modulation of an Experimental Prolonged Pain Model Using High Definition Transcranial Direct Current Stimulation

The purpose of this double-blinded, parallel group randomized controlled trial is to investigate the effects of high definition transcranial direct current stimulation (HD-tDCS) on an experimental prolonged pain model in healthy subjects.

The purpose of this double-blinded, parallel group randomized controlled trial is to investigate the effects of high definition transcranial direct current stimulation (HD-tDCS) on an experimental prolonged pain model in healthy subjects. Forty healthy participants are administered the compound Nerve Growth Factor (NGF) in the right first dorsal interosseous muscle (FDI), which produced prolonged muscle soreness and hyperalgesia.

The forty participants are randomly allocated to either the control group receiving a Sham-tDCS paradigm, or the intervention group receiving three consecutive days of multimodal HD-tDCS targeting primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) simultaneously.

The somatosensory profile is assessed at baseline, before administration of NGF as well as prior and post each HD-tDCS session using standardised quantitative sensory testing.

It is hypothesised that the active HD-tDCS will modulate the neurological changes induced by the experimental pain condition, which will alleviate the hyperalgesia and hypersensitivity.

Eligibility Criteria:
Inclusion Criteria:

* Healthy men and women.
* Able to speak, read and understand English or Danish.

Exclusion Criteria:

* Pregnancy
* Drug addiction defined as the use of cannabis, opioids or other drugs
* Current use of opioids, antipsychotics, benzodiazepines
* Previous or current neurological, musculoskeletal, rheumatic, malignant, inflammatory or mental illnesses
* Current or prior chronic pain conditions
* Lack of ability to cooperate
Barbed Suture Versus Traditional Suture Material for Laparoscopic Myomectomy

The objective of this study is to determine if the use of a new type of barbed suture material for laparoscopic myomectomy (surgical removal of fibroids) versus the traditional approach of suturing with conventional suture material to close the uterine defect once the fibroid has been removed, improves surgical outcomes. Specifically, the investigators will investigate the effect of barbed suture on operative time, blood loss, adverse post-operative events and hospital stay.

Although the laparoscopic myomectomy has benefits over the abdominal approach, such as less blood loss, less hemoglobin drop post-operatively, decreased post-operative pain and fewer overall complications, it is a difficult procedure, which often requires greater operative time to perform. In the current climate of attempting to reduce health care expenditures, even though the minimally invasive approach offers the advantage of reduced hospital stay, a deterrent for hospital administration and surgeons may be the increased operative time it may require. Barbed suture is a relatively new material available in gynecologic surgery. Barbs are cut into the suture with the barbs facing in a direction opposite that of the needle. The barbs allow for anchoring of the suture in tissues, which prevents migration and allows suturing without knot tying. This study will be a single-centre non-blinded randomized controlled trial comparing laparoscopic myomectomy with barbed suture versus traditional suture material.

Eligibility Criteria:
Inclusion Criteria:

* women who are planning to undergo laparoscopic myomectomy

Exclusion Criteria:

* greater than five fibroids
* uterus extending beyond the umbilicus
* major medical comorbidity or psychiatric illness, which could affect follow-up and/or compliance
* patients undergoing concomitant surgical procedures at the time of myomectomy (such as resection of endometriosis or ovarian cystectomy)
* pregnancy (all patients will have serum pregnancy testing prior to surgery)
* patients with any suggestion of abnormal pathology on imaging or endometrial biopsy
A Comparison Between Lumen-apposing Metal Stent and Double-pigtail Plastic Stents for Treatment of Walled-off Necrosis

Walled-off necrosis (WON) is defined as an encapsulated collection of solid and liquid necrotic material that is usually formed 4 weeks after an episode of acute necrotizing pancreatitis. As the advances in endoscopic techniques and accessories, Endoscopic ultrasound (EUS)-guided transluminal drainage has evolved to become the treatment of choice for symptomatic pancreatic walled-off necrosis (WON). This article aims to compare the efficacy and safety of a double mushroom head metal stent and a double pigtail plastic stent in the treatment of encapsulated necrosis of the pancreas.

According to the revised Atlanta classification, pancreatic fluid collections (PFCs) include acute peripancreatic fluid collections(APFCs) and acute necrotic collections(ANCs), which, over time, turn into pancreatic pseudocysts (PPs) and walled-off pancreatic necrosis (WON). Drainage of these PP and WON is required when they increase in size and become infected or become symptomatic.

Traditionally, WON has been managed surgically, however, surgical necrosectomy is associated with substantial morbidity and mortality, particularly when pursued early. In recent years, with the development of minimally invasive techniques, Endoscopic ultrasound (EUS)-guided transluminal drainage has evolved to become the treatment of choice for symptomatic pancreatic walled-off necrosis (WON).

Double-pigtail plastic stents(DPPS) is the earliest stent used for WON drainage in ultrasound endoscopy, however, These stents are limited by their small diameter leading to increased risk of stent obstruction. Recently, lumen-apposing metal stents (LAMS) have been increasingly used because of the advantage of better lumen apposition and wider diameter, improving access for endoscopic debridement. However, more adverse events(AEs) such as bleeding have been reported.

This article aims to compare the efficacy and safety of DPPS and LAMS in the treatment of Walled-off necrosis

Eligibility Criteria:
Inclusion Criteria:

* Obtention of a written informed consent
* According to Revised Atlanta Classification, abdominal CT/MRI and EUS were diagnosed as WON
* The diameter of WON ≥6cm
* Patient capable of fill in the quality of life questionnaire
* The distance between the EUS-probe and WON was \< 1 cm.

Exclusion Criteria:

* No written informed consent
* pancreatic cystic tumor, pancreatic cancer and other benign and malignant tumors
* pancreatic pseudocyst
* WON too far from the stomach and duodenum to perform endoscopic drainage
* Serious abnormalities in liver and kidney function and coagulation function
* Pregnant, parturient or breastfeeding women
Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

The main purpose of this prospective study is to demonstrate the therapeutic equivalence of topical brinzolamide dosed three times daily compared with AzoptTM (brinzolamide ophthalmic suspension 1%) dosed three times daily in IOP reduction in patients with POAG or OH.


Eligibility Criteria:
Inclusion Criteria:

* Male and females 18 years of age or older,
* diagnosed with primary open-angle glaucoma or ocular hypertension.

Exclusion Criteria:

* Patients with any form of glaucoma (such as secondary, congenital, juvenile or normal tension glaucoma, angle closure glaucoma) in either eye other than primary open-angle glaucoma,
* ocular hypertension.
Efficiency And Tolerance Of Hazelnut Oral Immunotherapy Protocol In Hazelnut Allergic Children

Prevalence of food allergy in the world has been inscreasing in recent years. Among nut allergy, hazelnut allergy is the most widespread in Europe and particularly in France. The current treatment for hazelnut allergy is based on eviction and wearing of an emergency kit with adrenaline auto-injector pens, to be used in the event of severe anaphylactic reaction. Oral immunotherapy (OIT) is a treatment that is now increasingly being offered as an alternatice to eviction. There are few published data concerning hazelnut OIT in Europe, where its consumption is nevertheless very high.

The main objective of our study is to evaluate the clinical efficacy of the hazelnut OIT protocol, implemented since 2015 in the pneumology and allergology-paediatric department of the Mother and Child Hospital in Bron, in hazelnut allergic children under 18 years old.

The secondary objectives will be to evaluate the biological efficacy and clinical tolerance of the protocol.

The study is retrospective and observational, and is based on the collection of medical data from patient records.


Eligibility Criteria:
Inclusion Criteria:

* Aged Under eighteen years old
* Hazelnut allergy (clinically and biologically)
* Under IOT hazelnut protocol in Pneumo/allergology-paediatric departement of the Mother and Child hospital in Bron

Exclusion Criteria:

* Lack of consent to be included in the study (by their parents)
* Age \> 18 years old
YM598 in Patients With Rising PSA After Initial Therapy for Localized Prostate Cancer

The purpose of this study is to determine the optimal dosage of YM598 for slowing down disease progression in patients with rising PSA after initial therapy for localized prostate cancer.


Eligibility Criteria:
Perioperative Use of a Selective COX2 Inhibitor in Patients Undergoing Elective Colorectal Surgery: the Effect on Post-operative Bowel Motility and Post-operative Pain

Perioperative Celecoxib to promote bowel movement and to reduce post-operative pain after elective colonic resection.

Post-operative ileus is a common surgical complication occurring in with up to 20% of patients, with a significant clinical and economical effect.

Many preventative measures have been tested to promote gastrointestinal motility following intestinal surgery have been suggested.

The medical intervention in the proposed study includes administration of a selective COX-2 inhibitor, specifically Celecoxib, in the peri-operative period following an elective colon resection. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic therapeutic effects.

The drug is approved for use in by the ministry of health in Israel and in the United states. The study aims to assess the use of this widely used medication for evaluation of the clinical effect on post-operative bowel transit, as well as the drugs' effect on post-operative pain.

Eligibility Criteria:
Inclusion Criteria:

* Patients between the age of 18 and 80
* Patients planned for elective colorectal surgery with primary anastomosis
* ASA score of 1-3
* Patients that are able to sign an informed consent and comply with the protocol

Exclusion Criteria:

* Patients with inflammatory bowel disease
* Patients that require emergency surgery
* Patients with renal failure, measured by Creatinine level \> 1.5 mg/dL (\>106.1 micro mol/l)
* Patients with significant liver failure (known cirrhosis, Bilirubin level\>2 mg/dL or 34.2 µmol/L)
* Patients with known allergy to any medication from the non-steroidal anti-inflammatory drug group.
* Patients treated chronically with any type of COX inhibitor.
* Patients treated with NSAIDS including Aspirin 7 days prior to the date of surgery.
* Patients with active peptic disease
* Patient expected to take muscle relaxants, tricyclic antidepressants, tranquilizers, sedatives, hypnotics or neuroleptics in the postoperative period
* Patient with dysphagia or that have a difficulty swallowing capsules or tablets, or is unable to tolerate oral medication
* Pregnant / lactating women.
* Patients participating in any other interventional clinical trial
MYREPTIC-N® or MY-REPT® in Stable Patients After Kidney Transplant Recipients

The purpose of this study is to Evaluate the Efficacy and Safety of MYREPTIC-N® or MY-REPT® in Stable Patients after Kidney Transplant Recipients

This study is a multi-center, Randomized, Open-label and phase IV clinical trial that evaluates the efficacy and safety of MYREPTIC-N® or MY-REPT® administration for 24 weeks in renal transplant patients combined Calcineurin inhibitor.

Eligibility Criteria:
Inclusion Criteria:

1. Over 19 years old
2. Patients who at least 1 year after kidney transplant
3. serum creatinine ≤2.3 mg/dL
4. Patients on immunosuppressive maintenance therapy using combination of Calcineurin Inhibitor and Mycophenolate Mofetil after kidney transplantation

Exclusion Criteria:

1. Patients who had received treatment Acute rejection within 4 weeks
2. Patients who had discontinued corticosteroid within 4 weeks
3. At the time of Screening

   * Treatment with active liver disease or Liver function test(T-bilirubin, AST, ALT)is over 3 times than upper normal limit
   * WBC\< 2,500/mm\^3, or platelet \< 75,000/mm\^3, or ANC \< 1,300/ mm\^3
4. In investigator's judgement
Impact of the Coordinated Intervention of the Healthcare Facilities Pharmacist and the Dispensary Pharmacist on the Care Pathway for Cancer Patients Treated With Oral Therapy

The rise of oral therapies in the management of cancers has considerably changed the patient care path. If the oral route is preferred by patients because it offers a better quality of life, it is not without impact for patients and the health professionals involved in their management in their care. Indeed, the use of the oral route shifts part of the responsibility for monitoring treatment towards the patient, thereby leading to compliance problems, drug interactions and the management of adverse effects.These risks can cause complications or compromise the effectiveness of treatment, and generate additional costs for the investigator's health system. The study proposes to involve Healthcare Facilities Pharmacist and the Dispensary Pharmacist with all other health professionals.First, the hospital pharmacist will operate before the initiation of an oral route to perform a clinical pharmaceutical analysis of drug prescriptions. Then after the primary prescription and finally during a follow-up consultation 3 months after the initiation of treatment. The hypothesis of the study is that the coordinated intervention of the hospital pharmacist and of the dispensary pharmacist would improve the tolerance of oral treatments by reducing the number of serious adverse effects found, as well as improve the, quality of life, patient and professional satisfaction


Eligibility Criteria:
Inclusion Criteria:

* Patient aged 18 years old or more
* Having given his written consent to participate in the study
* Patients with advanced or metastatic solid tumor or relapsed hematologic malignancy
* With an initiation of oral therapy
* Performance Status 0, 1 or 2

Exclusion Criteria:

* Patient receiving ongoing intravenous (IV) or subcutaneous (SC) anticancer treatment
* Patient receiving ongoing oral therapy
* Patient receiving first-generation hormone therapy
* Patient receiving ongoing a coordinated pharmaceutical path
* Patient participating in a therapeutic education program including a pharmacist
* Patient already included in an interventional clinical trial
* Oral therapy with Temporary Authorisation
* Patient in a health or medico-social institution
* Patient protected, under guardianship or unable to give free and informed consent
* Patient does not speak French
* Patient unable to read French
* Patient unable to undergo the medical monitoring of the trial for geographical, social or psychological reasons.
* Patients 70 years old with cognitive disorders identified by the G-CODE
Sedation vs. Intubation for Endovascular Stroke TreAtment

Sedation vs Intubation for Endovascular Stroke TreAtment Trial (SIESTA) is a prospective, randomised controlled, monocentric, two-armed, comparative trial. Patients are randomized 1 : 1 to either non-intubated state or to intubated state for endovascular stroke treatment. Otherwise, no principal differences in intensive care treatment are intended, and standard operating procedures are applied to ensure uniform management decisions in fields such as ventilation, sedation, cardio-vascular and cerebral monitoring and management.

Early recanalization is an important, if not the most important, factor concerning reconstitution of patients´ health in ischaemic stroke. This is the reason why patients with extended stroke are increasingly subjected to an endovascular stroke therapy (EST).

Matter of ongoing debate is how to sedate these patients during intervention. Some clinicians prefer an intubation due to a reduction of patients´movements and therefore potentially lowering complication rates (injury by catheter, aspiration e.g.).

On the other hand retrospective investigations hypothesize that general anaesthesia is associated with peri-interventional hypotension followed by poorer clinical outcome.

The best anaesthaesiologic management in endovascular stroke therapy to this point of time is not known. The investigators therefore designed this study comparing intubated state with general anaesthesia vs. non-intubated state with conscious sedation during EST, focusing on patients´ outcome.

Eligibility Criteria:
Inclusion Criteria:

* age ≥18 years
* acute stroke in anterior circulation
* occlusion of carotid artery and/ or middle cerebral artery
* planned mechanical recanalisation
* informed consent from patient or legal representative

Exclusion Criteria:

* age \< 18 years
* informed consent not obtainable
* coma
* agitation
* vomiting
* difficult airway management
* additional cerebral hemorrhage
The Impact of WeChat Group Patient Education on the Eradication Rate of Helicobacter Pylori

In this study, effects of oral and written education, WeChat education plus oral and written education on Helicobacter pylori eradication will be compared in a randomized way.

There are two randomized parallel groups in this study, control group and Wechat group.All of the patients will be treated with Amoxicillin + Clarithromycin + Bismuth + Vonoprazan fumarate. In control group,the patients will be educated by oral and written way about the regimen. In Wechat group, the patients will be educated by Wechat oral and written way. Then, the eradication rates, compliance, adverse events, patients' satisfaction and experience will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

1. aged between 18 and 75 years old;
2. H. pylori infection confirmed by any two positive outcomes of rapid urease test (RUT), 13C-urea breath test (UBT) or histopathology.

Exclusion Criteria:

1. previous therapy for H. pylori;
2. with significant underlying disease (e.g. decompensated liver cirrhosis, renal failure or malignant tumors) that may interfere the study;
3. history of gastric surgery,
4. pregnancy or lactation;
5. the use of PPI or antibiotics during the 4 weeks prior to enrolment;
6. previous history of allergic reactions to any of the medications used in this protocol;
7. unable to use smartphone and wechat
8. unwilling or incapable to provide informed consents.
Is the Measured Diameter of the Optic Nerve Sheath by Cerebral Scan in Patients With Early-phase Meningeal Hemorrhage, Due to a Ruptured Aneurysm, a Prognostic 6-month Mortality Factor ?

Sub Arachnoid Hemorrhage (SAH) is a public health concern because of its high incidence (7/100 000 inhab.), its mortality rate (25%), and its morbidity rate (50%).

Sub Arachnoid Hemorrhage (SAH) is a public health concern because of its high incidence (7/100 000 inhab.), its mortality rate (25%), and its morbidity rate (50%).

Prognostic tools are indispensable in guiding and optimizing the care of these patients.

Some diagnostic factors have been identified (e.g. age, comorbidities, ACSOS , GCS, ICP, occurrence of complications) as well as some classification schemes used for grading seriousness of the disease (Hunt and Hess, World Federation of NeuroSurgery).

A tool that is simple, reliable, reproducible, non costly, non invasive, and simple to perform (including remote methods and without changing planned patient care) would be ideal.

The measurement of the Optic Nerve Sheath Diameter (ONSD,) correlated by MRI and ultrasound in previous studies, with intra-cranial pressure (ICP: a fundamental prognostic factor for SAH) could be one of these tools.

This measurement, previously demonstrated using ultrasound, could be carried out at the time of the patient's initial cerebral scan.

In practice, at admission each patient undergoes a cerebral CT scan much more often than an ultrasound (faster, less costly, less technical training required).

Two preliminary studies seem to suggest that this measurement of ONSD on CTc is a predictive factor for morbi-morbidity in patients having serious traumatic skull fractures.The measurement is reliable, reproducible, non invasive, and non costly, with good sensitivity and specificity.

Proving that it is also applicable to SAH could be particularly useful.

Eligibility Criteria:
Inclusion Criteria:

* Patients 18 years or older
* Patient admitted to the Neurosurgical Urgent Care Unit for SAH following a ruptured aneurysm
* Patients or one of their loved ones providing written informed consent
* Patients with healthcare coverage

Exclusion Criteria:

* Unavailability of a CTc in the initial phase (within the first 12 hours) or absence of 1-mm slices from the scan
* Trauma to the optic globe or optic nerve pathology
* Preexisting anomalies of ICP or history of neurosurgical cerebral pathologies
* SAH of non aneurysm origin (e.g. arterio-venous malformation (AVM), tumor, trauma, sepsis)
* Patients under legal protection