cyrilzakka/clinical-trials huggingface dataset:
EMG Biofeedback and NMES of Deltoid in Patients With rTSA

The effect of NMES and surface electromyography (sEMG) biofeedback on the deltoid and associated scapular muscles in scapular kinematics and muscle activation in individual post rTSA

Reverse total shoulder arthroplasty (rTSA) has been the optimal treatment for massive irreparable rotator cuff tears and cuff tear arthropathy. Since scapular kinematics alteration was associated with shoulder disorders, scapular kinematics had been characterized in individuals post rTSA with more upward rotation, external rotation, and posterior tilt of the scapula. In addition, the average scapulohumeral rhythm ranged from 1.1 to 1.6, indicating lower glenohumeral joint movements and higher scapulothoracic movements. It supposed that more scapula upward rotation without adequate humeral elevation can result in the scapula notching. Therefore, strategy to decrease scapular movement or increase humeral movements during arm movements may prevent scapula notching. To compensate for rotator cuff deficiency, the deltoid muscle plays a crucial role post rTSA. Enhancing deltoid function can be accomplished through the use of biofeedback or neuromuscular electrical stimulation (NMES). However, the effect of NMES and surface electromyography (sEMG) biofeedback on the deltoid and associated scapular muscles in scapular kinematics, muscle activation, and muscle balance ratio in individual post rTSA remained unclear. Therefore, the objectives in this study would to (1) determine the immediate effects of NMES with EMG biofeedback to deltoid (D) on the muscle activation of upper trapezius (UT), lower Trapezius (LT) and serratus Anterior (SA) as well as the scapular kinematics (upward/downward rotation, external/internal rotation, anterior/posterior tilting) (2) evaluate the immediate effects of NMES with EMG biofeedback on the muscle balance ratios (D/UT, D/LT, D/SA) and the scapulohumeral rhythm (SHR) during arm elevation in the scapular plane at different range of motion.

Eligibility Criteria:
Inclusion Criteria:

* (1) age between 20 to 85 years old
* (2) undergoing primary reverse shoulder arthroplasty
* (3) shoulder abduction in scapular plane above 90 degrees
* (4) above 3 months following rTSA

Exclusion Criteria:

* (1) a history of other shoulder surgery on the rTSA shoulder
* (2) a revision rTSA
* (3) a surgery shoulder muscle tendon transfer
* (4) neuromuscular diseases
* (5) cognitive disorders
* (6) contraindications for NMES
DCP (RaDiCo Cohort) (RaDiCo-DCP)

Primary Ciliary Dyskinesias (PCD) are rare, autosomal recessive respiratory diseases, due to a defect in mucociliary clearance linked to abnormalities in the structure and/or function of the cilia. The variety of ciliary abnormalities identified reflects the genetic heterogeneity of PCDs. The thirty or so genes currently implicated explain the pathology in about half of the patients. PCDs are characterized by recurrent infections of the upper (rhinosinusitis) and lower (bronchitis) airways, beginning in early childhood and progressing respectively to nasal polyposis and bronchial dilatation. In half of the cases, there is a lateralization defect of the organs (situs inversus) corresponding to Kartagener's syndrome. There is more frequent infertility in men (immobility of spermatozoa) than in women (miscarriages and tubal pregnancies). About a third of patients progress to respiratory failure. The identification of predictive factors of severity, specific to PCDs, would improve patient care. It is also important to assess the quality of life of patients with PCD, particularly at the ENT level.

Data from prevalent patients are currently integrated into three separate and complementary databases: the "e-RespiRare" database, the "DCP Cils" database and the "DCP genes" database. The first step is therefore to constitute the RaDiCo-DCP database which will include data from prevalent and incident patients whose diagnosis of PCD is certain.

The cohort aims to improve the routine care of PCD patients, in particular by highlighting predictive factors of severity, allowing early and personalized care, to assess the social impact (quality of life) and medical conditions of ENT impairment, as well as adult infertility, to finely characterize the ciliary phenotype. The study also aims to search for new DCP genes and to allow genotype/phenotype correlation studies.


Eligibility Criteria:
Inclusion Criteria:

* Patient fulfilling at least one of the following criteria for PCD confirmed diagnosis: Kartagener's syndrome and/or specific anomaly of the ciliary ultrastructure and/or an unambiguous mutation in a PCD gene
* Having at least one annual follow-up visit

Non-inclusion Criteria:

* Patients with an unconfirmed diagnosis of PCD
* Patients with an evolving concomitant pathology that may interfere with the assessment of PCD-related manifestations
Two Year Study With Robotic-Arm Assisted Hip Surgery.

This study will involve a quantitative assessment of prospectively collected computed tomography, radiographic and patient outcomes data from multiple centers. Specifically looking at acetabular cup placement during Total Hip Arthroplasty by either traditional or robotic-arm assisted placement.

The incidence of dislocation following total hip arthroplasty (THA) has been reported to be from 1% to as much as 3.2%. The demand for THA is expected to increase. Post- dislocation solutions include closed reduction, open reduction, THA revision, and constrained cup, conversion to hemiarthroplasty, allograft or girdlestone resection. These solutions are often costly, painful and can involve substantial additional risks and complications. Acetabular cup placement is an important factor in the stability of the THA. Cup malpositioning has been associated with bearing surface ware and dislocation. For most patients, acceptable angles for abduction are 40° abduction (±10°) and 20° (±5°) version. However, malpositioning continues to occur resulting in cup angles outside acceptable ranges and leaving patients with an increased risk of dislocation.

This objective of this study is to examine the acetabular cup placement of THA patients and compare results for patients who undergo THA with robotic-arm assistance with those who undergo traditional THA.

Eligibility Criteria:
Inclusion Criteria:

1. Patients requiring primary total hip arthroplasty
2. Patients willing and able to comply with follow-up requirements
3. Patients willing to sign an Institutional Review Board approved informed consent form.

Exclusion Criteria:

1. Patients with Body Mass Index \>45
2. Patients who are \<18 years of age
3. Patients with an active infection or suspected latent infection in or about the hip joint
4. Bone stock that is inadequate for support or fixation of the prosthesis
5. Previous major hip surgery excluding hip arthroscopy
6. Total hip arthroplasty using cement fixation or resurfacing
Urine Drug Levels Related to Source of Water for Irrigation for Vegetable Crops Among Healthy Israeli Volunteers

Over 60% of crops in Israel are grown in recycled treated waste water. This study aims to determine whether minute quantities of drugs such as Carbamazepine can be found in individuals who ingest vegetables grown in waste water.

40 healthy volunteers will undergo a food frequency questionnaire and ask to undergo a daily food diary.They will also be asked about drug exposure.

At baseline they will provide a urine and hair sample to determine presence of pharmaceuticals.

They will then undergo a crossover trial wih one week exposure to vegetables grown in recycled waste water or fresh water, with a three day wash out period. Participants will be asked to ingest a minimal amount of lettuce, carrots, peppers, tomatoes and lettuce during the study period.

During this period questionnaires will continue and urine samples will be collected every three days. The first compound to be tested will be carbamazepine, as it is stable in water.

It is important to note that vegetables provided to the participants are available in regular grocery stores.

Participants will be asked to drink bottled water throughout the study period . A sample of their home drinking water will also be tested for Carbamazepine as will a sample of the vegetables they consume.

Eligibility Criteria:
Inclusion Criteria:

* men and women
* age 18-68

Exclusion Criteria:

* ingestion of carbamazepine,
* pregnancy
* vegetarian
* pure organic diet
Adaptive Servo-Ventilation in "Real Life" Conditions : the OTRLASV Study

Adaptive Servo-Ventilation (ASV) treatment is routinely prescribed in France. In order to be reimbursed according to the French Social Security rules, the patient treated with an ASV needs to be examined each year. In this observational transversal single-visit study, the investigators aim to describe the clinical characteristics of patients treated with ASV and the associated device settings.

The purpose of this study is to evaluate in "real life conditions" the use of Adaptative Servo-Ventilation (ASV) treatment. ASV treatment is routinely prescribed in France in patients with various sleep disorders breathing (Chronic Heart Failure (CHF) and Central Sleep Apnea Syndrome (CSAS), CHF and central and obstructive sleep apnea (COSA), Obstructive Sleep Apnea Syndrome (OSAS) and complex sleep apnea syndrome (compSAS), idiopathic or drug induced periodic breathing.

In order to be reimbursed according to the French Social Security rules, the patient treated with an ASV needs to be examined each year. In this observational transversal single-visit study, the aim is to describe the clinical characteristics of patients treated with ASV and the associated device settings. The aim is to evaluate the safety and efficacy issues in real life conditions of the ASV prescription.Depending of the data, data are obtained after analysis of the six latest months data of the ASV device, after questioning the patient, after analysis of the polygraphy/oximetry (if prescribed by the doctor for the renewal consultation of the ASV care and reimbursement by the French Social Security). All the data are obtained during the annual consultation required by the French Social Security.

Eligibility Criteria:
Inclusion Criteria:

* Written informed consent
* Age more than 18 years (inclusive)
* Patient treated with ASV for at least one year,and eligible for care and for the reimbursement by the French Social Security rules.
* Patient presenting at the annual control consultation for the continuation of the ASV treatment according to the French Social Security rules.

Exclusion Criteria:

* Pregnancy, intention of being pregnant, breastfeeding.
* Inability to understand the nature and aims of the study or to communicate with the investigator
* Simultaneous participation in another trial with an exclusion clause to participate to an other trial.
* No affiliation to the French social security
* Loss of personal capacity resulting in state protection
* Deprivation of liberty by judicial or administrative decision
The Effect of NAC in Decreasing the Incidence of Linezolid-induced Thrombocytopenia in Critically Ill Patients

* Study the effect of acetylcysteine on decreasing the incidence of LIT in critically ill patients.
* Study the impact of acetylcysteine on the time to onset of LIT and the time to recovery of platelets.

Primary outcome: difference in incidence of LIT between patients who received NAC and patients who didn't.

* Primary outcome definition: Defined as platelets \< 150000 OR decrease \> 50% of baseline platelets.
* Secondary outcome: difference in Time to onset of LIT and time to recovery between the 2 groups.
* Secondary outcome definitions: after having thrombocytopenia, regardless of discontinuation of linezolid, recovery is defined as the restoration and maintenance of platelet counts \> 70% of baseline values.

Eligibility Criteria:
Inclusion Criteria:

* All adult patients, age \> or = 18 years old, admitted to the ICU with different indications.
* Candidates for intravenous linezolid therapy for \> or =1 day.

Exclusion Criteria:

* Taking any myelosuppressive drug.
* Baseline platelets \< 50000.
* Patients with hematological malignancy.
* COVID-19 patients.
* Patients with immune thrombocytopenia.
* Patients who refused to sign the informed consent
Intra-muscular Botulinum Toxin A in Chronic Athletic Pubalgia

Chronic athletic pubalgia is a frequent sport condition in which the effectiveness of medical treatment has not been proven. Intra-muscular injection of botulinum toxin A may have positive effects on pain in some chronic tendinitis.

The investigators hypothesized that similar analgesic effect of intra-muscular botulinum toxin A may be observed in individuals with chronic AP. In the present study, the investigators aimed to describe the short-term evolution of pain and of activity limitations and quality of life, after an injection of the adductor longus with botulinum toxin A, in individuals with chronic AP, for whom medical and/or surgical treatments have failed.

The investigators included consecutive individuals with chronic athletic pubalgia for whom medical and/or surgical treatments have failed and who were treated with an intra-muscular injection of botulinum toxin A under ultrasound guidance. Participants were assessed 50 days after injection for pain using a numerical rating scale (NRS) (0, no pain, and 100, maximal pain) and for activity limitations and quality of life using the Copenhagen Hip and Groin Outcome Score (HAGOS) (0, worse outcome, and 100, most favorable outcome). Participants were also asked to self-report adverse events.

Eligibility Criteria:
Inclusion Criteria:

* chronic AP
* symptom duration ≥ 3 months
* consistent clinical and magnetic resonance imaging findings according to the clinician
* failure of medical and/or surgical treatments with persistent pain and inability to return to play
* treatment with an intra-muscular injection of botulinum toxin A injection

Exclusion Criteria:

* age under 18 years
* ongoing pregnancy or breastfeeding
* treatments by anticoagulants
* muscular disorder (e.g. polymyositis, myopathy or other neuromuscular conditions)
* guardianship or curatorship
* individuals who had received botulinum toxin type A treatment for less than one year
Tissue and Serum Collection From Colorectal Cancer Patients

To establish a serum and tissue bank with specimens form patients with colorectal cancer, for subsequent immunological and biochemical analysis.


Eligibility Criteria:
Inclusion Criteria:

* Patients must be undergoing surgery for resection of their primary tumor, resection of hepatic metastases, or hepatic artery catheter and pump implant for unresectable hepatic metastases.
* For and tumor specimen removed at surgery ,the lesion must be large enough to allow for routine pathological analysis, with excision from residual otherwise discarded material for the tumor bank.

Exclusion Criteria:

N/A
Fluid Balance Study in Sick Neonates

The purpose of this study is to determine if routinely recording fluid balance in sick neonates admitted to the pediatric ward is reliable and useful. The investigators' hypothesis is that it is not useful and reliable.

Fluid balance charts are commonly used, in the Netherlands, to assess patient fluid volume status. Some disadvantages of recording fluid intake and output are that it is time-consuming and complex. If it would give reliable and accurate information about the fluid volume status there would be a good reason for all this effort. In the few researches that have investigated this subject a low correlation has been found between the fluid balance and the weight changes of an adult patient. Own experience gives reasons to doubt about the reliability of the fluid balance in children, not rarely there is a discrepancy between the fluid balance and the weight measurement. We are interested in the relevance of recording fluid balance in neonates.

Eligibility Criteria:
Inclusion Criteria:

* Sick neonates admitted to the neonatal ward

Exclusion Criteria:

* Admitted elsewhere before admission to the neonatal ward
* Indication for recording fluid balance
* Impossibility to measure the weight every day
* No consent parents
Evaluating the Optimal Volume Voided for Passage of a Backfill-Assisted Voiding Trial Following Urogynecologic Surgery

Urinary retention can lead to bladder over-distention, ischemia, and long-term voiding dysfunction, and early identification of urinary retention can help prevent these adverse events

Postoperative voiding trials (VT) can identify as well as prevent postoperative urinary retention. Voiding trial protocols vary by provider and healthcare facilities/institutions as there is no consensus on how to prevent postoperative urinary retention optimally. Identification of an optimal VT could not only help decrease adverse events associated with urinary retention but also decrease postoperative catheter-associated urinary tract infection (CAUTI) rates, unplanned hospital or clinic visits, and decrease patient discomfort while increasing patient satisfaction.

Eligibility Criteria:
Inclusion Criteria:

* Nonpregnant women \>18yo undergoing pelvic organ prolapse or urinary incontinence surgery

Exclusion Criteria:

* Patients undergoing fistula repair or sacral neuromodulation
* Voiding dysfunction preoperatively that requires intermittent self-catheterization
* Intraoperative bladder injury
* Pregnancy
* Preoperative UTI (culture proven within 7 days prior to surgery)
Effects of Peanut Intake on Cognitive Functions

The study will test the effects of Peanuts on task-related brain activation and cognitive functions in older adults with memory complaints.

The purpose of the study is to determine the effects of peanuts on cognitive performance and task-related brain activation on functional magnetic resonance imaging (fMRI) in older adults. The specific aim of the study is to explore the neuroprotective effects of a peanut-enriched diet (2-3 oz of peanuts to replace 20% of the total energy of the habitual diet) for 12 weeks compared to a peanut-excluded habitual diet in elderly men and women with increased risk for CVD and self-reported memory complaints. The study population is older adults 60-80 years in age.

Eligibility Criteria:
Inclusion Criteria:

* Non-demented elderly between 60-80 years of age
* Self-reported memory complaints
* Two cardiovascular risk factors
* Stable weight for at least 6 months prior to recruitment

Exclusion Criteria:

* Peanut allergy
* Smoker
* Endocrine, metabolic and neuropsychological disorders
* Ineligible to get an MRI
* Consuming more than 3 servings/week of nuts including peanuts
High-intensity Functional Circuit Training and Cognitive Function

The study investigates the acute effects of one bout of high-intensity functional circuit training on cognitive function against no-activity control and aerobic exercise.

Exercise has been shown to acutely improve cognitive function (CF). However, it is unknown as to how high-intensity functional circuit training (HIFCT) affects CF. This study aims to compare the acute effects of one HIFCT bout against an inactive control condition as well as against one bout of conventional aerobic exercise.

Healthy participants will be randomly allocated to either a HIFCT group, an aerobic exercise group (walking) or an inactive control group. In the HIFCT group, participants perform a 15-minute workout, which is composed of functional exercise mimicking activities of daily living (e.g. squat, step-ups) and conducted in a circuit format. Each exercise is performed at all-out intensity for 20 seconds, followed by a 10-second break. Thus, the 15-min workout consists of 30 exercise intervals.

In the control group, participants will be inactively seated for 15 minutes, reading sports brochures and literature.

In the walking group, participants will walk at moderate intensity on a treadmill for 15 minutes.

Outcomes assessed pre and post-workout include the stroop test, trail making test, stop-signal task, heart rate, subjective arousal, rate of perceived exertion and exercise enjoyment.

Eligibility Criteria:
Inclusion Criteria:

* 18-40 years

Exclusion Criteria:

* severe orthopaedic, psychiatric, neurological, endocrine or cardiovascular disorders
* acute illness, not completely healed injuries
* muscle soreness
* pregnancy/nursing period
Magnetic Prefrontal Stimulation for Studying the Role of the Cortex in High-level Cognition Processes and Reward System

The investigators intend to study the role of the cortex in high- level cognition processes and sensory adaptation, by the use of non-invasive Transcranial Magnetic stimulation and various cognitive tests.


Eligibility Criteria:
Inclusion Criteria:

* healthy men and women, age of 18-60
* answered negatively to questions of TMS safety questionnaire
* signed and declared about their agreement to participate in the study
* hebrew speaker

Exclusion Criteria:

* self history of significant mental disorder
* self history or first-degree relatives history of epilepsy
Sea Swimming for Treatment of Depression and Anxiety

There is a developing evidence to suggest that open cold water swimming could have an impact on depression and anxiety:

* anecdotal reports of benefits to mental wellbeing as a result of regular open water bathing
* research suggesting exercise is as effective as medication and talking therapies in the treatment of depression
* ecotherapy (offering therapeutic intervention in nature) has a developing evidence base
* cold water may have an impact on the inflammatory system which has been linked to depression

The aim of this study is to recruit 10 people with mild to moderately severe depression to a sea swimming course, alongside their standard care. The course would involve two groups of 5, participating in eight sea sessions under the guidance and supervision of swim instructors and lifeguards.

The primary aim of the course is to determine the recruitment rate and compliance with the course.

The secondary aims of the course are to determine the impact on mental health through questionnaires for depression (PHQ9), anxiety (GAD7), functioning in daily life (WSAS). The inflammatory marker - C- reactive protein (CRP), will also be measured to monitor the inflammatory process in relation to psychological outcomes and the timeline of the course.

Participants will need to commit to two sessions a week. It is anticipated that participants will need to commit around 2 hours of their time to the study each week.

It would take around ten months from recruitment to follow-up. Participants would be able to leave the study at any time. Participants would engage in routine care alongside the course.

Sea swimming can be a dangerous activity but participants would be well supported, in small groups and would only sea swim in safe conditions. Participants will be asked to report any medical conditions to ensure they could not be adversely effected.


Eligibility Criteria:
Inclusion Criteria:

* Adults living in North Devon and able to attend the course.
* PHQ-9 score 5-19
* Able to swim two lengths of a 25m pool

Exclusion Criteria:

* Physical health problems that would make cold water immersion a risk including significant heart problems, inadequately treated high blood pressure e.g. new diagnosis not on stable medication, significantly reduced mobility.
* Experience of other mental health problems at a significant level
* Not able to swim or very anxious about getting into water
* Suicide risk
* Unable to speak English (as the sea swimming course will be conducted in English)
* Unable to consent due to lack of capacity