cyrilzakka/clinical-trials huggingface dataset:
Postprandial Effects of High-fat Meals With Different Dairy Products on Lipid Metabolism and Inflammation

The aim of this project is to elucidate how high-fat meals with different kinds of dairy products affect postprandial responses of lipid metabolism and inflammatory markers in healthy and obese subjects.


Eligibility Criteria:
Inclusion Criteria:

* The study will include both men and women aged 18-70 years with the aim of an even age and gender balance.
* Participants in the healthy group will need to have a body mass index (BMI) between 18.5 - 24.9 kg/m2 and a waist circumference (WC) of \<94 cm for men and\<80 cm for women.
* Participants in the obese group will need to have a BMI of ≥25 kg/m2 and a waist circumference of ≥94 cm for men and ≥80 cm for women.
* All subjects must be willing to eat three slices of bread with a dairy product and jam as breakfast.

Exclusion Criteria:

* BMI \<18.5 kg/m2 or \>25 kg/m2 in the healthy group and \<25 kg/m2 in the obese group
* WC ≥94 for men and ≥80 cm for women in the healthy group, \<94/80 cm for men/women in the obese group
* Weight change of ± 5 % of body weight in the last three months
* TG ≥1.3 mmol/L in the healthy group
* CRP \>10 mg/L
* Total cholesterol \>6.1 mmol/L for subjects 18-29 years, \>6.9 mmol/L for subjects 30-49 years and \>7.8 mmol/L for subjects ≥50 years old
* Blood pressure \>160/100 mm Hg
* Comorbidities including diabetes type I and II (blood glucose ≥7 mmol/L fasting), coronary heart disease, haemophilia, anaemia (hemoglobin \<120 gram/L), gastro intestinal disease and hyperthyroidism (TSH \>4 mU/L)
* Pregnant or lactating
* Allergic or intolerant to gluten, milk protein and/or lactose
* Use of medications affecting lipid metabolism or inflammation
* Unwilling to seponate omega-3 rich supplements four weeks prior to screening and during the study period
* Hormone treatment (stabile dose of contraception or thyroxin for the last three months excepted)
* Blood donation two months prior to test day 1 or during the study period
* Tobacco smoking
* Excessive regular alcohol consumption (\>40 grams per day) or prior to the test day
Strados System at Center of Excellence

Listening to breath sounds with the stethoscope/auscultation is used by pulmonary physicians in conjunction with pulmonary function, signs and symptoms, oxygen saturation and diagnostic testing to admit, follow and discharge patients from hospital. Of these, only auscultation routinely ceases upon discharge from Hospital. Healthcare utilization statistics have shown that for more than a decade, readmission after discharge for an exacerbation of COPD or severe asthma (or chronic heart failure) remains a major problem. The Strados System has been designed to extend the range of lung sound recording both geographically and temporally to improve the standard of care when access to continuous monitoring has been replaced by periodic or no monitoring. The primary purpose of this study is to assess the clinical utility of the Strados System in enabling periodic recording and reviewing of breath sounds in patients with chronic respiratory diseases, either in the ICU, or in less continuously monitored settings, including after inpatient discharge.


Eligibility Criteria:
Inclusion Criteria:

Potential study participants will be recruited from within the Einstein Center of Excellence. Individuals who meet all of the following criteria are eligible for enrollment as study participants:

1. Males and females between the ages of 18-80:

   With documented physician-diagnosed COPD (chronic bronchitis dominant) or severe asthma, as defined either by the American Thoracic Society or the World Health Organization who are admitted for exacerbation, including those with active or suspected SARS-COV-2 infection

   OR

   Who are admitted with respiratory distress symptoms associated with SARS-COV-2 infection
2. Able to provide informed consent
3. Able to follow study procedures
4. Clinician assessment of the patient's current SARS-COV-2 status: negative or unlikely to be infected, RTPCR positive, or untested by clinically suspected
5. Accessible by telephone upon discharge

Exclusion Criteria:

Subjects who meet ANY of the following criteria are not eligible for enrollment:

1. Inability or unwillingness of the participant to give written informed consent
2. History of adverse reaction or allergy to Tegaderm
3. Unwillingness or inability to comply with study procedures
4. Scheduled for thoracic procedure
5. Inaccessible by telephone post-discharge
Remodeling of Distal Coronary Vessel in Chronic Total Occlusions: Prediction Based on Hemodynamic Coronary Parameters

Background Revascularization of a chronic total occlusion (CTO) has gained popularity last decade. After recanalization there is an acute gain in vessel diameter, as well as a late lumen gain distal to the stent as a result of positive remodeling. The evolution of a recanalized CTO-vessel is however diverse. Several studies are performed to measure distal lumen gain and hemodynamic coronary parameters of a recanalized CTO, including the novel measurement Absolute Flow. Although the results seem promising, an association between those parameters and distal vessel lumen gain has never been found. The aim of this study is to understand the remodeling of the distal coronary vessel in relation with hemodynamic coronary parameters, establishing baseline predictive factors, adding new information about coronary physiology.

Objectives:

To establish baseline predictive factors for acute and late lumen growth after successful opening of chronic total occlusions. Secondary objectives are 1) Identifying the relation between change in absolute microvascular resistance and late change distal lumen diameter at the end of the index procedure and at 3 months follow-up, 2) Identifying the relation between late lumen growth and stent malapposition, assessed using Optical Coherence Tomography (OCT) and 3) Identifying the relation between angina-related symptoms, assessed using the Seattle Angina Questionnaire-7 (SAQ-7), and absolute microvascular resistance.

Hypothesis:

Acute and late lumen growth are dependent on preprocedural distal coronary artery perfusion pressure, decrease in microvascular resistance and growth of absolute antegrade flow. Late lumen growth predisposes for late stent malapposition.

Study design:

A single-center, prospective, observational cohort study. The center performing this study will be the Radboudumc.

Study Population:

30 patients scheduled for an elective revascularization procedure of a CTO and Heart-team consensus for the indication of a CTO treatment.


Eligibility Criteria:
Inclusion Criteria:

* Scheduled elective revascularization procedure of a CTO, defined as a complete obstruction of a coronary artery with TIMI-0 or TIMI-1 flow and occlusion duration of at least 3 months
* Heart-team consensus for the indication of a CTO treatment, based on viability and ischemia testing (using TTE or MRI)
* Able to give valid, written informed consent

Exclusion Criteria:

* Unsuccessful crossing of the lesion during PCI
* Renal insufficiency defined as eGFR \< 30 ml/min
* Contra-indications to intravenous adenosine
* \< 18 years of age
* Pregnancy
Chronic Intestinal Pathologies Analytical Cohort at TouLouse

In the general population, the percentage of people with at least one digestive disease is 16.7%. Among these digestive diseases, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and patients who should benefit from digestive examinations as part of a screening oriented either by the patient's family history or following the performance of an immunological screening test ( FIT) in the stool will be studied. The aim of this project is to build a biological collection with associated clinical data for research projects.

In the general population, the percentage of people with at least one digestive disease is 16.7%. Among these digestive diseases, two of them namely inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) will be more particularly studied. This interest is based on the increasing frequency of these two pathologies, their chronicities but above all the limited physiopathological data available. In addition, it seems interesting to study a third population, namely patients who should benefit from digestive examinations as part of a screening oriented either by the patient's family history or following the performance of an immunological screening test ( FIT) in the stool. The study of this population is part of an improvement in knowledge on the carcinogenesis of colorectal cancer.

To study these populations, blood, serum, plasma and tissues from colonous biopsies or surgical samples will be collected.

This cohort will make it possible to study, among other things, the pathophysiology of chronic diseases of the small intestine and the colon (IBD, IBS, screening) in order to improve their management through the development of new biomarkers and therapeutic targets.

Eligibility Criteria:
Inclusion Criteria:

* Patient requiring endoscopic explorations for screening or follow-up in the context of a suspected IBS or IBD or colorectal cancer Or
* Patient with IBD requiring surgical management
* Patient over 18 years old
* Patient able to read and understand the information leaflet
* Patients who have given their consent to participate in the study
* Patients affiliated to a social security system (including AME)

Exclusion Criteria:

* Patients who have received antibiotic treatments in the 10 days preceding endoscopic exploration
* Pregnant or breastfeeding patients
* Patients under 18 years old
* Patients under guardianship or curatorship
* Patients unable to sign a free and informed consent
Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis

The purpose of this study is to evaluate whether the investigators can develop a computer algorithm to predict which individual patients will respond to injections of hyaluronic acid (HA) products for knee osteoarthritis.

Background Osteoarthritis (OA) of the knee is a debilitating condition that affects an estimated 21 million Americans. This number is expected to rise steadily as the population ages. The medical expenditures associated with arthritis and other rheumatic conditions in the United States have increased from $50 billion in 1997 to $86 billion in 2003. In 2003, almost 420,000 total knee replacements were performed, primarily for arthritis. Injections of hyaluronic acid (HA) have been shown to provide symptom relief for many OA patients who have failed to respond to conservative interventions. Many other patients, however, experience only slight or no improvement. The results from this study will allow physicians to identify whether a patient is likely or not likely to respond well to HA therapy leading to improved treatment success rates.

Goals This study has two related goals: 1) to identify patient and treatment factors that predict response to intra-articular injections of hyaluronic acid for knee osteoarthritis using multivariable analysis and 2) develop mathematical and statistical models that will predict individual patient response to HA for knee OA.

It is anticipated that the investigators will develop computer software in this study that can support clinical decision making related to viscosupplementation in the treatment of knee OA. If this project yields successful patient predictive models, physicians who are considering a trial of HA for a patient will have some empirical basis for treatment selection. Eventually a physician would be able to assess a relatively small number of variables for a patient and then be provided with predictions regarding treatment response.

\*\*Please note that the study site at the Naval Medical Center in Portsmouth, Virginia can only enroll patients who are eligible to be treated at a military facility.

Eligibility Criteria:
Inclusion Criteria:

* Symptomatic knee osteoarthritis presenting to physician's office
* Radiographic evidence of knee osteoarthritis
* Age 18 years or older
* Failed minimum of 3 months of non-operative treatment, including, but not limited to, Tylenol, anti-inflammatory medication, cortisone injection, physical therapy, bracing, and/or heel wedge
* Symptoms for at least 3 months

Exclusion Criteria:

* Associated ligamentous instability
* History of deep knee infection
* Candidate for total knee arthroplasty or arthroscopy
* Peripheral neuropathy.
* X-rays that are completely negative and only MRI evidence or arthroscopic evidence (from previous arthroscopy) of OA.
* Prior HA injections at any point in the past
* Chondrocalcinosis
* Patients with precautions or contraindications for viscosupplementation use
* Cortisone injection within past 3 months
Attachment and Prognostic Factor: the Implicit Approach

This is a prospective longitudinal study aimed at better understanding the determinants of the prognosis of patients with substance dependence.

5 visits are planned during the study :

* the inclusion visit : during this visit the patient's non-opposition is obtained and then the patient answer to self-administered questionnaires online
* 4 telephone interviews for follow-up by investigator.


Eligibility Criteria:
Inclusion Criteria:

* Patients between 18 and 65 years old
* Patients with a use-related disorder as defined by DSM5
* Patients weaning for a substance, supported within the addictology sector of Henri Laborit Hospital
* Having expressed non-opposition to participating in the study after receiving written information.

Exclusion Criteria:

* Person who cannot read or write
* Simultaneous participation in a therapeutic trial involving oxytocin
* Patients protected by law
* Patients who do not have French as their native language
* Patients who, in the opinion of the investigator, are unable to complete the questionnaires
Ratio of the Cross Sectional Area of Median Nerve to Ulnar Nerve in Diagnosing Carpal Tunnel Syndrome

An innovative diagnostic ultrasound method for carpal tunnel syndrome was proposed and compared between carpal tunnel syndrome patients and healthy volunteers.


Eligibility Criteria:
Inclusion Criteria:

* CTS patients were required to have subjective symptoms of numbness, tingling pain, or dysesthesia over the median nerve innervated area of the involved hand.
* Patients should have positive response in either Tinel's test or Phalen's test during physical examination
* Evidence of median neuropathy at wrist level in NCS.
* Control subjects should have neither symptoms nor signs of CTS along with no abnormal findings in electrodiagnostic study of the median nerve and the ulnar nerve across the wrist joint.

Exclusion Criteria:

* Age younger than 20 years old
* Electrodiagnostic evidence of ulnar neuropathy at the wrist level
* Previous trauma or surgery history of hand
* Medical history of hypothyroidism, diabetes mellitus, uremia, rheumatoid arthritis, amyloidosis, and acromegaly
* Pregnancy
Trial to Reduce Hospitalizations in Children With Medical Complexity

The investigators hypothesize that an intervention, within an established patient-centered medical home, aimed at reducing modifiable risks for hospitalization, can decrease hospital utilization among medically complex children.

The investigators will pilot test an intervention that includes contingency planning and care transitions within an established medical home program caring for children with medical complexity. Children with medical complexity receiving care within the UCLA Medical Home Program will be randomized to the pilot intervention or usual medical home care. The primary goal will be to reduce admissions and readmissions in the intervention group.

Eligibility Criteria:
Inclusion Criteria:

* Children ages 0 to 17 years old who are enrolled in the Pediatric Medical Home Program at UCLA
* English and Spanish-speaking only

Exclusion Criteria:

* Children older than 17 years old who are enrolled in the Pediatric Medical Home Program
* Non-English and Non-Spanish speakers
Epstein-Barr Virus Antibody and Epstein-Barr Virus DNA for Nasopharyngeal Carcinoma Screening

The investigators intend to compare Epstein-Barr virus antibody and Epstein-Barr virus DNA screening efficacy in first-degree relatives of nasopharyngeal carcinoma patients.

The investigators intend to test Epstein-Barr virus antibodies (Viral Capsid Antigen-immunoglobulin A， Epstein-Barr nuclear antigen 1-immunoglobulin A， early antigen-immunoglobulin A， Zta-immunoglobulin A， Rta-immunoglobulin G, Bnlf 2b) by ELISA and Epstein-Barr virus DNA by quantitative polymerase chain reaction, target sequencing and CRISPR-associated protein 12a in nasopharyngeal brushing and plasma of the same population at high-risk of nasopharyngeal carcinoma so as to determine the best method in nasopharyngeal carcinoma screening.

Eligibility Criteria:
Inclusion Criteria:

* residents in Southern China
* 30-62 years old
* male
* a first-degree relative of at least one nasopharyngeal carcinoma patient
* no medical record of nasopharyngeal carcinoma
* Eastern Cooperative Oncology Group score of 0-2
* be able to comprehend, sign, and date the written informed consent document to participate in the study

Exclusion Criteria:

* history of nasopharyngeal carcinoma
* heavy cardiovascular, liver or kidney disease
* on systemic steroid or immunosuppressant treatment or active autoimmune disease
Establishment of Sleep Quality, Physical and Mental Health and Occupational Burnout Management Model for Shift Nursing Staff and Evaluation of Its Effectiveness

The purpose of this study was to investigate the relationship between the personal characteristics and work characteristics of shift nurses and occupational burnout, sleep quality and physical and mental health. Use " acupressure " as an intervention to compare the status of shift nurses before and after intervention and to track after interventional therapy, 1, 2, and 3 months of longitudinal results.

The purpose of this study was to investigate the relationship between the personal characteristics and work characteristics of shift nurses and occupational burnout, sleep quality and physical and mental health. Use " acupressure " as an intervention to compare the status of shift nurses before and after intervention and to track after interventional therapy, 1, 2, and 3 months of longitudinal results. Use the "Smart Care VIP bracelet" to detect physical and mental conditions (psychological stress, physical fatigue) to assess the applicability of the Smart Care VIP bracelet as a "Shift Care Staff Sleep Quality, Physical and Mental Health and Occupational Burnout Management System" and evaluate effectiveness, and establishment of an effective management system.

Most studies in China have shown that the use of acupressure to improve the sleep quality of nursing staff generally has its efficacy, but the lack of research at proves that acupressure is used by nursing staff to improve sleep quality and improve occupational burnout. It is expected to be from May to December 2020. The nursing staff of a medical center in Taipei will be selected for stratified sampling. The conditions for receiving the case are shift nurses who have served in the institution for more than one year. Subjective sleep is assessed using Epworth sleepiness scale. The objective part is to use the "Smart Care VIP Bracelet" to measure sleep time; Chinese version of the Chinese Health Questionnaire-12 (CHQ-12) and occupational burnout scale questionnaire as a tool for discussion. It is planned to randomly assign shift nurses to 42 acupressure groups and control group (sham), and use activity record (Smart Care VIP bracelet) to monitor and record fatigue Index and stress changes.

Eligibility Criteria:
Inclusion Criteria:

1. Shift nursing staff who have been employed in this institution for more than one year, and there have been more than two shift types in the past year. Can fill out the questionnaire and agree to participate in this research and sign the consent form.
2. Chinese Health Questionnaire-12 \> 1.5
3. Epworth sleepiness scale \> 6.5 points

Exclusion Criteria:

1. Long-term (more than one month) taking sleeping pills such as Benzodiazepines, Stilnox, Imovane, etc.
2. Nursing staff in the same ward as the PI.
3. Encountered major life problems one month before the intervention, such as: falling out of love, family member's accident, personal diagnosis of illness, etc.
Effect of Solar Salt Diet in Elderly Hypertensive Patients

High sodium intake causes hypertension. Various efforts for reducing salt consumption are proceeding all over the world. Solar salt contains reduced sodium and abundant mineral, such as calcium, potassium, and magnesium, comparing to ordinary salt. Use of solar salt, instead of ordinary salt, may have beneficial effects to blood pressure.

The investigators are going to conduct a preliminary study that can support antihypertensive effect of solar salt intake.


Eligibility Criteria:
Inclusion Criteria:

* above 50 years elderly hypertensive patients
* possible oral intake

Exclusion Criteria:

* dementia, GDS\>6
* terminal cancer patient
Gene Therapy With Modified Autologous Hematopoietic Stem Cells for the Treatment of Patients With Mucopolysaccharidosis Type I, Hurler Variant

This is a phase I/II study evaluating safety and efficacy of autologous hematopoietic stem and progenitor cells genetically modified with IDUA lentiviral vector encoding for the human α-L-iduronidase gene for the treatment of patients affected by Mucopolysaccharidosis Type I, Hurler variant

Pediatric patients with mucopolysaccharidosis type I will be treated with genetically modified autologous hematopoietic stem cells collected from mobilized peripheral blood (or bone marrow if mobilization is not feasible) and transduced with IDUA lentiviral vector encoding for the human α-L-iduronidase gene.

Patients will be followed for 5 years after gene therapy. After completing participation in this study, subjects will be offered enrollment into an approved long term follow-up (LTFU) study which will enable continued follow-up for up to 15 years post-treatment (per regulatory guidelines for follow up of patients treated with ATMPs).

Eligibility Criteria:
Inclusion Criteria:

* Written informed consent by parent/legal guardian
* Sex: Males and Females
* Age: ≥ 28 days and ≤ 11 years old
* Biochemically and molecularly proven MPS IH
* Lansky index \>80%
* Indication to hematopoietic stem cell transplant
* Lack of a non-heterozygous (for mutated IDUA) HLA-matched sibling donor or a ≥7/8 (4 digits high-resolution typing) HLA-matched cord blood donor with a cellularity ≥5 x 10\^7 Total Nucleated Cells (TNC)/Kg after 1-month search.(This criterion will not apply to patients whose country of origin does not offer unrelated donor cord blood transplantion).
* Adequate cardiac, renal, hepatic and pulmonary functions

Exclusion Criteria:

* Use of other investigational agents within 4 weeks prior to study enrolment (within 6 weeks if use of long-acting agents)
* Severe, active viral, bacterial or fungal infection at eligibility evaluation
* Patients affected by neoplasia or family history of familial cancer syndromes
* Cytogenetic alterations associated with high risk of developing hematological malignancies
* History of uncontrolled seizures
* Patients with end-organ damage or any other severe disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study
* Positivity for HIV (serology or RNA), and/or HbsAg and/or HBV DNA and/or HCV RNA and/or Treponema Pallidum or Mycoplasma active infection
* Patients with DQ/IQ \<70
* Previous allogeneic hematopoietic stem cells transplantation or gene therapy with a different product
* Contraindications to PeIMP (G-CSF, Plerixafor, Busulfan, Fludarabine, Rituximab)