cyrilzakka/clinical-trials huggingface dataset:
Ilioinguinal Nerve Excision in Open Mesh Repair of Inguinal Hernia,a Randomized Clinical Trial

this study was designed to evaluate the effect of routine excision of the ilioinguinal nerve in an attempt to decrease the incidence of chronic inguinodynia in patients who undergo open anterior hernia mesh repair.

As chronic pain is the 2nd most common complication following open hernia repairs and it causes limitations and dysfunctions for the patients and also according to some previous studies elective ilioinguinal neurectomy could result in less postoperative pain,we decided to perform a randomized double blind clinical trial.The primary goal of this study was evaluation of the effect of this type of neurectomy on postoperative pain and hyposthesia.

Eligibility Criteria:
Inclusion Criteria:

* having an age of over 18 years

Exclusion Criteria:

* Those with diabetes, incarcerated, bilateral and recurrent hernias and visual problems were excluded from the investigation.
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia

This research is studying the long term use of a nasal airway device (self-supporting nasopharyngeal airway; "ssNPA") in children with hypotonic upper airway obstruction to learn about its effectiveness and tolerability as a treatment for obstructive sleep apnea.


Eligibility Criteria:
Inclusion Criteria:

* Children with Hypotonic Upper Airway Obstruction (HUAO) that took part in the original study (HUM00189669/NCT04846400 or HUM00220966/NCT05527652 trials)
* Willingness to continue device usage.
* Confirmed diagnosis of OSA (apnea/hypopnea index; AHI \&gt; 10 or AHI \&gt;5 with lowest oxygen level ≤75%)
* At least one symptom of OSA (such as frequent snoring, daytime sleepiness, or hyperactive/inattentive behaviors)
* Previous adenotonsillectomy (unless tonsillectomy not possible)
* Tonsil size 2+ or smaller

Exclusion Criteria:

* Participants that were non-compliant with the Self-Supporting Nasopharyngeal Airway (ssNPA) device during participation in the parent study listed above
* Any medical reason why ssNPA therapy may not be suitable
* Active COVID 19 infections Moderate/severe tracheobronchomalacia
* Need for anticoagulative therapy
* Bleeding disorder
* Restrictive thoracic disorders
A Study of ABT-751 in Patients With Colorectal Cancer

The purpose of the study is to determine if ABT-751 will decrease tumors, and determine how long the tumor shrinkage can be maintained in patients with colorectal cancer. Patients will receive ABT-751 by mouth daily for 21 days. Patients will be off drug for 7 days before starting the next cycle of drug.


Eligibility Criteria:
Inclusion Criteria

* Colorectal cancer.
* Recurrent tumor following treatment with irinotecan and/or oxaliplatin.
* Able to tolerate normal activities of daily living.
* Adequate bone marrow, kidney, and liver function.

Exclusion Criteria

* Pregnant or breast feeding.
* Anti-tumor therapy within 4 weeks of the start of ABT-751 administration.
* Prior radiation therapy.
* CNS metastasis.
Pain Related to Head and Neck Cancer (HNC); Implementation and Evaluation of Self-care Measure Due to the Same Illness

The purpose of this study is to evaluate the effect of individual education and individual self-care measures on pain intensity, perceived health, mood and sleep during and after treatment with radiotherapy for head and neck cancer.

The purpose of this study is to evaluate the effect of individual education and individual self-care measures on pain intensity, perceived health, mood and sleep during and after treatment with radiotherapy for head and neck cancer

Eligibility Criteria:
Inclusion Criteria:

All HNC patients who went through RT and were referred to the Pain and Rehabilitation Centre at the University Hospital (Linköping, Sweden) were invited to participate in the study which run from January 2015 - March 2017.

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Exclusion Criteria:

Non Swedish speaking individuals, severe social and/or psychological disorders, severe cognitive conditions,other serious medical conditions.

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Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhalation to Improve Host Defense and Pulmonary Barrier Restoration

This trial evaluates efficacy and safety of inhaled molgramostim (rhGM-CSF) in 45 patients with pneumonia associated acute respiratory distress syndrome (ARDS). A third of the patients will receive 150 mcg inhaled molgramostim, another third 450 mcg and the remaining third will receive inhaled placebo for 3 days. The patients will be followed for 28 days.


Eligibility Criteria:
Inclusion Criteria:

1. Signed informed consent form by the patient or a legal representative according to local regulations
2. Man or woman 18 to 75 years of age, inclusive
3. Women who have been post-menopausal for more than 1 year or women of childbearing potential period using a highly efficient method of contraception (i.e. a method with less than 1% failure rate such as combined hormonal contraception, progesterone-only hormonal contraception, intrauterine device, intrauterine hormone-releasing system, bilateral tube occlusion, vasectomized partner, sexual abstinence) during dosing and hospitalisation. Women must have a negative serum or urine pregnancy test before the first dose of study medication and must not be lactating.
4. Diagnosis of pneumonia-associated ARDS, where the underlying condition is Community-Acquired Pneumonia (CAP) or Hospital-Acquired Pneumonia (HAP) in patients not on invasive ventilation upon diagnosis of HAP.
5. Diagnosis of ARDS according to the Berlin ARDS definition.
6. Requirement for positive pressure ventilation (non-invasive or via endotracheal tube) for more than 72 hours in total with inspiratory oxygen concentration (FiO2) ≥ 50% (or less when on additional ECMO therapy) not longer than 14 days

Exclusion Criteria:

1. Receiving vasopressors of \>100 µg/min
2. History of liver cirrhosis Child Pugh C, chronic hemodialysis (before severe pneumonia/ARDS), lung cancer
3. Malignancy with expected survival time of less than 6 months
4. History of or listing for lung transplantation
5. Highly immunosuppressive therapy or anti-malignant combination chemotherapy within 3 weeks prior to first dose of study drug
6. Any anti-malignant chemotherapy within 24 hours prior to first dose of study drug
7. AIDS or known history of HIV infection
8. Pregnancy
9. Autoimmune thrombocytopenia, myelodysplastic syndromes with \> 20% marrow blast cells
10. History or presence of hypersensitivity or idiosyncratic reaction to molgramostim or to related compounds (i.e., Growgen®, Leucomax®, Leukine™, Topleucon™)
11. Participation in another clinical trial within 90 days prior to the first dose of study drug
Does Engagement with Heritage Sites Have the Potential to Improve Sub-clinical Levels of Low Wellbeing in NHS Staff: a Feasibility Study. the HerWellNHS Study

This feasibility study will focus on assessing and identifying the wellbeing effects of self-directed (unmediated) visits to heritage sites for a high-risk population, specifically NHS staff at PHU self-reporting sub-clinical levels of low wellbeing. In particular, it seeks to understand whether wellbeing effects can be derived from unmediated visits to heritage sites, how much exposure to heritage is necessary to experience wellbeing effects, whether and how benefits may be accumulated, how long wellbeing effects may last following visits, and the nature of these wellbeing effects. In addition, it will establish appropriate psychological measures (qualitative and quantitative), test a web-based data collection interface, examine participant choices and their characteristics, and assess participant adherence and response rates prior to developing a clinical trial.

This feasibility study will use quantitative and qualitative psychological measures to examine participant choices of heritage sites and their characteristics, as well as assessing participant adherence and response rates prior to development of a future clinical trial.

It will act as proof of concept, generating a case for the promise of unmediated heritage visits as an effective mental health intervention.

The project will focus on assessing and identifying the wellbeing effects of unmediated visits to heritage sites for NHS staff, and seeks to understand how much exposure to heritage is necessary to experience wellbeing effects, how benefits may be accumulated, how long wellbeing effects may last following a visit, and what the nature of these wellbeing effects may be. The study also seeks to capture the staff experience of engaging with heritage sites, what are the aspects which might result in positive change as a result of the interactions as well if there are any potential risks associated with such interventions.

This project is funded by Historic England. The project partners are as follows: Portsmouth University NHS Hospitals, The Royal Navy National Museum, The Mary Rose Museum, Wessex Archaeology, Portsmouth City Council, Art as Media and the University of Southampton.

Eligibility Criteria:
Inclusion Criteria:

The participant must meet ALL of the following criteria to be considered eligible for the study:

* Male or Female, aged 18 years or above.
* Self-reported subclinical levels of low wellbeing
* Participant is willing and able to give informed consent for participation in the study.
* NHS Staff at Portsmouth Hospitals University NHS Trust

Exclusion Criteria:

The participant may not enter the study if ANY of the following apply:

* Having been diagnosed with and/or received treatment for any mental health issues in the past 12 months
* Under 18
* Unable to give informed consent for participation in the study
Administration of Probiotics in Cirrhotic Patients Listed for Liver Transplantation

The aim of this study was to evaluate the impact of the administration of probiotics on outcomes of patients qualified for liver transplantation, both in the pre-transplant period and in the early postoperative period.

Gut microflora plays an important role in the pathogenesis of complications of liver cirrhosis, mainly due to microbial translocation. According to several studies, administration of probiotics in patients with cirrhosis has positive effect on minimal hepatic encephalopathy. The aim of this study was to evaluate the impact of probiotics administration on outcomes of patients qualified for liver transplantation, both in the pre-transplant period and in the early postoperative period. This study will be performed on 200 patients randomized into the probiotic and placebo groups. Daily administration of either probiotics or placebo will be continued from the date of inclusion in the study until the date of liver transplantation. A quantitative and qualitative analyses of faecal microflora will be performed in each patient before and after 10 week period (or shorter, depending on the time on the waiting list) of administration of either probiotic or placebo. Microbiological analyses of air samples from patients' home environment will be performed in each case. Both groups of patients will be compared with respect to primary and secondary outcome measures.

Eligibility Criteria:
Inclusion Criteria:

* Liver cirrhosis
* Active status on the waiting list for liver transplantation
* Confirmed etiology of liver disease

Exclusion Criteria:

* Malignancy
* Human Immunodeficiency Virus infection
* Immunosuppressive treatment prior to liver transplantation
* Cystic fibrosis
* Creatinine clearance rate \< 50 mL/min
Online-supervised Exercise Program in Elderly People With Diabetes

This study was conducted to determine the effect of an online-supervised exercise program on fasting blood sugar, psychological resilience, and quality of life in elderly people with diabetes. A parallel-group, randomized controlled trial design was used. The study was conducted in a public hospital with 70 patients with elderly type 2 diabetes between Nowember 2021 and May 2022. A Personal Information Form, The Brief Resilience Scale and A Measure of Quality of Life in the Elderly were used to collect data.


Eligibility Criteria:
Inclusion Criteria:

* Having a diagnosis of Type 2 diabetes mellitus for at least 6 months,
* Being aged \>50 years,
* Receiving oral antidiabetic and/or insulin therapy,
* Having a smartphone or a computer,
* Volunteering to participate in the study,

Exclusion Criteria:

* Individuals who had type 2 DM, but were illiterate
* Had vision and hearing loss
* Did not volunteer to participate in the study
Evaluation of Crestal Bone Loss Around Short Dental Implants As Affected By Two Suprastructure Materials

The aim of the study is to evaluate the crestal bone loss developed around short dental implants after using screw retained Hybrid ceramic crowns when compare to screw retained Lithium Di silicate based ceramic crowns.

This study will be conducted on patients requiring single implant replacement in the posterior regions of the mandible, admitted to the Outpatient Clinic of Fixed Prosthodontics Department, Faculty of Oral and Dental medicine, Cairo University.

Examination and diagnosis:

1. Selection and examination of the patients according to inclusion and exclusion criteria.
2. Preoperative Cone Beam Computed Tomography (CBCT) to all patients.
3. Primary impression will be taken to produce study cast.
4. Taking a professional photo for the examined posterior area.
5. Patients will be divided into two group:

G1: Short implants will be restored by screw retained Hybrid ceramic crowns G2: Short implants will be restored by screw retained Lithium Di silicate based ceramic crowns

Surgical procedures:

* Implants will be placed following standardized protocol.
* After 4 months the patients re-attended for placement of healing abutments for about (10-14) days and prosthesis fabrication.

Data collection and post operative radio-logical assessment:

-Taking standardized digital peri-apical radio-graph by paralleling technique and film holding device for follow up at 12 months after crowns loading to evaluate crestal bone loss.

Eligibility Criteria:
Inclusion Criteria:

1. Patients within age group of ≥ 18.
2. There should be absence of any systemic diseases.
3. Patients have missing simple posterior tooth
4. Adequate interarch space.
5. Inadequate residual bone height to place standard length implant.
6. Patients with good oral hygiene.

Exclusion Criteria:

1. A history that would complicate the outcome of the study, such as alcohol or drug dependency, smoking, poor health, or any other medical, physical or psychological reason that might affect the surgical procedure or the subsequent prosthodontics treatment and required follow-up.
2. Heavy smokers.
3. Poorly controlled diabetes mellitus.
4. Patients on radiotherapy.
5. Patients with temporomandibular disorders
Pioglitazone Tablets Specified Drug-use Survey <Survey on Glycemic Control in Type 2 Diabetic Patients With a History of Cerebral Infarction>

The purpose of this survey is to evaluate the effects on glycemic control and to evaluate the safety of long-term use of pioglitazone tablets (Actos Tablets) in type 2 diabetic patients with inadequate glycemic control and a prior history of cerebral infarction.

This survey was designed to evaluate the effects on glycemic control and to evaluate the safety of long-term use of pioglitazone tablets (Actos Tablets) in type 2 diabetic patients with inadequate glycemic control and a prior history of cerebral infarction.

For adults, 15-30 mg of pioglitazone is usually administered orally once daily before or after breakfast. The dose should be adjusted depending on sex, age, and symptoms; however, the maximum daily dose should not exceed 45 mg.

Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetic patients with a prior history of cerebral infarction who meet all the following conditions, \[1\] to \[3\], at the time of enrollment in the survey:

  1. First onset of cerebral infarction was at least 24 weeks prior to enrollment
  2. HbA1c values ≥ 6.5% within 12 weeks prior to the start of treatment with Pioglitazone Tablets
  3. No prior history of treatment with Pioglitazone Tablets since the first onset of cerebral infarction

Exclusion Criteria:

* Patients who meet any of the following conditions, \[1\] to \[5\], shall be excluded from the survey:

  1. Contraindication for Actos Tablets
  2. Prior history of recurrence of cerebral infarction
  3. Prior history of cerebral hemorrhage or subarachnoid hemorrhage
  4. Complications or prior history of myocardial infarction, angina pectoris, cardiomyopathy, hypertensive heart disease, atrial fibrillation, atrial flutter, or valvular disease
  5. Reduced cardiac function (defined as an ejection fraction \[EF\] ≤ 40%)
Evaluation of Patients With Statin Myopathy Using an N of 1 Trial Design

This study consists of a series of prospective, randomized placebo-controlled n of 1 trials to objectively evaluate the reproducibility of subjective and objective symptoms among patients with a history of statin-related myopathy.


Eligibility Criteria:
Inclusion Criteria:

* history of muscle symptoms occuring within 3 weeks of starting a statin
* need for statin therapy to achieve LDL target according to the 2009 Canadian Lipid Guidelines
* willingness to re-try statin therapy

Exclusion Criteria:

* currently tolerant of statin therapy
* metabolic or inflammatory myopathy
* known neuropathy
* CK elevation \>3 times upper limit of normal (ULN) previously on a statin or history of rhabdomyolysis
* pregnant, breastfeeding, or wanting to become pregnant in the near future
* participation in another clinical trial
* other medical condition associated with decreased life span
* inability to adhere to stringent regimen
* unwilling to stop consumption of grapefruit juice

Subset of 5 patients also completing neuromuscular testing:

Inclusion Criteria:

- same as above

Exclusion Criteria:

* same as above but also:
* angina III of IV
* decompensated heart failure
* history of orthopedic problems
* have any skin ulcers or other non-healed skin areas or infections in the arm or leg
SEGMENTAL AND GENERAL STABILIZATION EXERCISES IN CHRONIC LOW BACK PAIN

Chronic low back pain effects more than 50% of general population. It's prevalence is higher is young adults that are economically active adults.

Its significance is often underestimated because usually young adults ignore these initial episodes of low back pain due to their busy life style or life full of commitments. Approximately 70% of adults have at least one episode of low back pain during their lifetimes.

It will be randomized control trial with 60 patients with chronic low back pain divided into 2 groups. One group will be given segmental stabilization whose purpose is to achieve segmental control over primary stabilizers. Second group will be given just generalized lumber stabilization exercises as it includes close chain exercises with low velocity as well as low load. This study will be conducted in Rehabilitation setup of Benazir Bhutto hospital Rawalpindi and IIRS that is Rehabilitation dept. at Al Nafees medical college and hospital, Islamabad. Non probability Convenience Sampling technique will be utilized

Eligibility Criteria:
Inclusion Criteria:

* Both males and females will be included in the study

Exclusion Criteria:

* Age limits of subjects will be between 15 to 60
Sleep Disordered Breathing, Endothelial Function, and Adverse Events in Pregnancy

This is a prospective longitudinal cohort study whereby pregnant individuals are asked to complete an 8-day testing protocol to measure their sleep and cardiovascular health at two timepoints during pregnancy.

The goal of this observational study is to examine the effect of sleep disordered breathing on the health of the heart and blood vessels of the mother during pregnancy. The main questions it aims to answer are:

* Is sleep disordered breathing associated with impaired the function of the heart and blood vessels in pregnancy?
* Is higher levels of physical activity associated with a reduced risk of sleep disordered breathing in pregnancy?

Participants will complete an 8 day long study protocol at two time points during pregnancy (20-24 weeks gestation and 28-36 weeks gestation). During each testing period they will be asked to:

* Complete one night of at-home sleep testing and and one night of overnight vital signs monitoring (ambulatory blood pressure and heart rate monitoring devices)
* Wear two accelerometers and complete a 7-day sleep log
* Complete a set of questionnaires
* Visit the laboratory for a fasted blood draw and ultrasound assessment of their cardiovascular health (resting heart rate and blood pressure, flow mediated dilation and pulse wave velocity tests)

Participants will also be asked to complete a short follow-up survey in the postpartum period.

Eligibility Criteria:
Inclusion Criteria:

* over 18 years of age
* pregnant (20-24 weeks gestation at enrollment)

Exclusion Criteria:

* worked shift work past 11pm in the previous month
* previously diagnosed with a sleep disorder by a physician
Incremental Value of Magnetic Resonance Imaging in Selection of Pancreatic Cancer Patients for Surgery

The aim of the study is to examine the incremental value of using magnetic resonance imaging (MRI) in addition to computed tomography (CT) in the diagnostic workup of pancreatic cancer patients.

The aim of the study is to examine the incremental value of using magnetic resonance imaging (MRI) in addition to computed tomography (CT) in the diagnostic workup of pancreatic cancer patients. We will conduct a nationwide, prospective clinical trial to examine the incremental value of using MRI for identification of liver metastases in pancreatic cancer patients.

Eligibility Criteria:
Inclusion criteria:

* Pancreatic cancer patients considered to have a locally resectable or borderline resectable tumor by the local hepato-pancreato-biliary multidisciplinary team board
* No liver metastases on CT
* At least 18 years old and able to provide informed consent
* Expected pancreatic ductal adenocarcinoma based on CT scan

Exclusion criteria:

* Metastatic disease
* Prior receipt of neoadjuvant chemotherapy or downstaging/-sizing treatment
* Comorbidity rendering major surgery unfeasible (inoperable)
* No informed consent
* Unable to undergo MRI (Kidney insufficiency (eGFR \< 60 ml/min/1.73 m2 body surface ar-ea); Claustrophobia; Cardiac pacemaker)
* Postoperative histology other than adenocarcinoma of pancreato-biliary origin.
* MRI with liver-specific contrast performed during standard workup.