cyrilzakka/clinical-trials huggingface dataset:
HairMax LaserComb Open Label Study to Treat Seborrheic Dermatitis

The purpose of this study is to test whether the stimulation of vascularization and cellular metabolism on the scalp by use of the HairMax LaserComb will produce improvement in the condition of scalp seborrheic dermatitis.

This is an open label pilot study to evaluate the effects of the low-level laser light on seborrheic dermatitis of the scalp. Dandruff assessment scores for scalps with seborrheic dermatitis will be assessed at baseline with monthly evaluations during treatment, until final assessment at end of treatment at week 12.

The trial will involve 10 patients aged 18 years and older with a diagnosis of seborrheic dermatitis. Patients will use the LaserComb device three times per week on non-consecutive days for 12 weeks. No other seborrheic dermatitis products will be used during treatment. The investigator will conduct measurements of dandruff at each study visit, as a measure of efficacy.

The trial consists of 4-5 study visits (screening/baseline, week 4, week 8 and week 12). Dandruff evaluation and adverse event assessments will be performed at each visit.

Safety analysis will be assessed based on the reports of adverse events during the study.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of seborrheic dermatitis of the scalp
* PGA of 2 (mild) or greater at baseline
* TDSS score at baseline of 2 or greater, for both scaling and inflammation
* Must agree to use of non-medicated shampoos during study period; must refrain from use of other medicated scalp products during the trial

Exclusion Criteria:

* Use of any topical or oral products that would affect assessment of the scalp SD condition, in the opinion of the primary investigator, within the following periods prior to baseline:

  * Medicated shampoos within 2 weeks of baseline
  * Topical scalp medications within 2 weeks of baseline
  * Oral medications affecting the scalp within 4 weeks of baseline
  * Other medications determined by the investigator to potentially affect the assessment of SD = washout to be determined by the investigator, as appropriate to the known medication properties
* Any current or past medical condition, including active dermatitis or any other dermatological condition, which might interfere with assessment of dandruff
* Patients using any medications that may increase photosensitivity, and thus pose a risk when undergoing LaserComb therapy
* Patients with known adverse reactions, allergy or hypersensitivity to laser light components/light sensitivity conditions
* Patients who have received any investigational drug within 30 days prior to study entry.
Establish Finite Element Mesh of the Numerical Models of the Thoracic Aorta

This study will be using finite element meshes and averaged algorithms to create the numerical thoracic aorta at different ages.

This study will be using finite element meshes and averaged algorithms to create the numerical thoracic aorta at different ages.

Eligibility Criteria:
Inclusion Criteria:

* Normal thoracic aorta
Hemodynamic in Postreperfusion Period and Functional Recovery in Acute Ischemic Stroke Patients

The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.


Eligibility Criteria:
Inclusion сriteria:

* ischemic stroke diagnosis
* performed intravenous thrombolysis (including "wake up stroke")
* systolic blood pressure \>140 mmHg
* informed consent or council of physician agreement

Exclusion criteria:

* absence of informed consent or council of physician agreement
* pregnancy
* patients participainting in other clinical trial in the last 90 days
* any absolute contraindications to intravenous thrombolysis

Сompletion criteria:

* failure to achieve hemodynamic goal for 20 minutes before the start of intravenous thrombolysis
* failure to achieve hemodynamic goal for 60 minutes in first 24 hours after intravenous thrombolysis
* relative arterial hypotension (SBP \<100 mmHg for 60 minutes in first 24 hours after intravenous thrombolysis)
* unfavorable effect development (e.g. seizures, angioedema)
* informed consent is retracted
Registry of Outcomes From AntiReflux Surgery

Prospective registry comparing outcomes after laparoscopic treatment of gastroesophageal reflux disease and hiatal hernia.

This is a prospective, multi center, observational database of patients that are having surgical laparoscopic antireflux procedure and/or hiatal hernia repair, including laparoscopic Nissen fundoplication and Magnetic Sphincter Augmentation with the LINX device. Patients meeting registry inclusion and exclusion will be followed for 5 years with standardized quality of life surveys and appropriate standard of care testing. Up to 40 sites will participate with total enrollment of 1000 patients.

The main objectives are to collect data from everyday clinical practices and track patients from preoperative assessments to 5 years post surgical intervention to evaluate symptoms, medication use and side effects.

Eligibility Criteria:
Inclusion Criteria:

* Subject must be at least 21years of age and at least the minimum Age of Majority according to applicable state law.
* Subject is a suitable surgical candidate, i.e. is able to undergo appropriate anesthesia and endoscopic procedure or laparoscopic surgery.
* Appropriate indications for and documentation of disease process requiring surgery. (Documented gastroesophageal reflux disease by accepted endoscopic or ambulatory reflux monitoring criteria, or have a hiatal hernia that meets accepted criteria for repair (e.g. large paraesophageal hernia with chest pain)).
* Subject is willing and able to cooperate with follow-up examinations
* Subject has been informed of the study procedures and treatment and has signed an informed consent for the study.

Exclusion Criteria:

* Suspected or confirmed esophageal or gastric cancer.
* Cannot understand trial requirements or is unable to comply with follow-up schedule
* Pregnant or nursing, or plans to become pregnant during the course of the study
* Medical illness (i.e. congestive heart failure) that may cause the subject to be non-compliant with or able to meet the protocol requirements or is associated with limited life expectancy (i.e. less than 3 years)
* Diagnosed psychiatric disorder (e.g. bipolar, schizophrenia, etc.), subjects that exhibit depression that are on appropriate medication(s) are allowable.
Overweight Adults--Ethnic, SES and Behavioral Influences

To examine the effects of ethnicity, socioeconomic status (SES) and behavior in overweight adults.

BACKGROUND:

In 1999, more than 55 percent of United States adults were overweight, an increase of 8 percent in fifteen years. Because overweight is associated with cardiovascular disease (CVD) morbidity and mortality, the alarming increase in overweight underscored the need for innovative and effective weight-loss interventions. Tailored interventions specifically designed for high-risk subgroups can compliment existing population-based approaches. However, before designing such interventions, sociodemographic characteristics of those at high risk must be identified.. Although past studies have shown that ethnicity is associated with overweight, these studies suffered from potential confounding from SES because ethnic minority groups are disproportionately poor. Past studies have been compromised by limited sample size at the extremes of SES such as higher SES Mexican-Americans or Blacks, and/or lower SES Whites.

Weight loss is affected by multiple perceptions and behaviors, such as perceptions of overweight, physical activity, dietary habits, smoking, and alcohol use. Although past epidemiological research has investigated the independent effects of such influences on weight, research to date has not identified whether distinct clusters of weight perceptions and behaviors exist among overweight adults. Given that such clusters may differ by sociodemographic characteristics, identifying clusters may contribute to the design of innovative and tailored weight-loss interventions that address the presence of multiple influences on weight loss and increase the likelihood of successful interventions.

DESIGN NARRATIVE:

The study had four specific aims: (1) to identify subgroups at high risk of overweight based on sociodemographic characteristics (e.g., ethnicity and SES): (2a) to determine whether distinct clusters of weight perceptions and behaviors exist among overweight adults and (2b) to determine whether the clusters differ by sociodemographic characteristics; (3) to determine whether clusters in the overweight sample exist among normal-weight adults, and (4) to propose tailored weight-loss interventions to be tested empirically in the future. Data were analyzed, by gender, for 3203 Black, 2989 Mexican-American, and 3761 white men and women, ages 25-64, who participated in the third National Health and Nutrition Examination Survey (NHANES III), 1988-1994). This national survey of the United States population over-sampled by the two largest ethnic minorities, Blacks and Mexican-Americans, and provided sufficient sample sizes at the extremes of SES.

Eligibility Criteria:
No eligibility criteria
LONGitudinal Multi-omics Phenotyping of KIDney Function Alteration

This is a longitudinal observation of kidney function, immune system and gut microbiota before and 24 weeks after a live kidney transplantation conducted in donor and recipient pairs living in the same household. Outcome measures include kidney function, body composition, blood pressure, gut microbiome composition, metabolomics and immune cell states.


Eligibility Criteria:
Inclusion Criteria:

* Body-Mass-Index 18,5 - 34,9 kg/m2
* Planned living kidney donation / transplantation

Exclusion Criteria:

* Clinically relevant heart, lung, liver, and kidney diseases
* Postoperative phase
* Acute infections
* Vegan diet
* Change of body weight of more than 10% in the month prior to study entry
* Known drug or alcohol abuse
Plasty or Prosthesis to Treat Functional Mitral Regurgitation

Functional Mitral regurgitation is a now well known entity due to tethering of the valve either mono-lateral, as happens in lateral myocardial infarction, or bilateral as happens in dilated cardiomyopathy. Treatment of this pathology, either conserving the valve and addressing regurgitation by mean of restrictive annuloplasty, or implanting a prosthesis remains controversial in terms of mid and long term benefit for the patient. The investigators propose a randomized controlled study to compare the efficacy of both technique in terms of mortality and freedom from reintervention.


Eligibility Criteria:
Inclusion Criteria:

* All patients presenting for surgery due to functional mitral regurgitation

Exclusion Criteria:

* Associated Heart Surgery procedures other than CABG, Tricuspid Regurgitation correction, Atrial Fibrillation Correction
HEMOCC Study. Hemostasis in Cirrhotic Children.

Prospective investigations into the role of hemostatic factors in the risk of variceal bleeding among children with chronic liver disease (thromboelastometry e.g) is still required. A better understanding of these factors would permit better risk stratification and targeted prophylaxis or therapy.

The investigators aim to start a prospective and observational study over a 2 years period.

First, the investigators will identify all children suffering from cirrhosis irrespective of underlying etiology and/or portal hypertension coming into the pediatric hepatogastroenterology unit at Saint-Luc University Clinics. Any patient with a congenital or acquired thrombophilia/haemorrhagic disorder will be excluded. The investigators expect to include 20 to 30 children in the study.

The investigators will meet the parents to give them explanations about this study and its implications. Then the investigators will get the free and informed consent about the participation to this clinical study. Parents are obviously free to refuse to take part in this clinical study and to retire from it at any moment.

Eligibility Criteria:
Inclusion Criteria:

* Children suffering from decompensated cirrhosis and needing an orthotopic liver transplantation
* Children suffering from a compensated cirrhosis (compensated cirrhosis with kasai surgery in biliary atresia patients e.g) or from portal hypertension without cirrhosis (portal vein thrombosis e.g)
* Each patient will have a comprehensive assessment of portal hypertension (abdominal US-Doppler and upper gastrointestinal endoscopy) and hemostasis

Exclusion Criteria:

* No underlying disease which can alter hemostasis (hemophilia, sepsis...)
* No medication which can alter hemostasis (aspirin, anti-inflammatory drugs,...)
NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII Palsy

Traumatic brain injury, stroke and other neurological conditions may result in weakness of the muscles that either open or close the eye. This is generally a result of impaired functioning of the oculomotor or facial cranial nerves. Current treatments to improve eye opening or closing are either invasive or largely ineffective. This study tests a noninvasive means of improving eyelid opening and closing by applying a previously demonstrated safe and effective neuromuscular electrical stimulation (NMES) intervention to the muscles controlling eyelid movement. Participants in this study will either receive the investigational NMES protocol 30 min per day for five days or a sham NMES for the same period. The primary outcome for this study is the participants' ability to open or close their affected eye. Secondary outcomes include additional measures of eye and corneal health.


Eligibility Criteria:
Inclusion Criteria:

* Cranial nerve III (oculomotor nerve) and/or cranial nerve IV (facial nerve) palsy.
* Able to read and communicate in English.

Exclusion Criteria:

* Idiopathic onset of CN III and/or CN IV palsy.
* Traumatic injury to the eye or eyelid.
* Active wounds in the treatment area.
* Presence of swelling or infection in or surrounding the affected eye.
* Diminished sensation in the area to be treated.
Serotonin-norepinephrine Reuptake Inhibitors and Acute Kidney Injury

The purpose of this study is to determine if there is an excess risk of acute kidney injury (AKI) with Serotonin-norepinephrine reuptake inhibitors (SNRIs) as compared to Selective serotonin reuptake inhibitors (SSRIs), two classes of medication used for the treatment of depression.

We plan to conduct retrospective population-based cohort studies within eight administrative databases from Canada, the United States, and the United Kingdom. Within each cohort, a nested case-control analysis will be performed to estimate incidence rate ratios (RR) of AKI associated with SNRIs compared to SSRIs using conditional logistic regression, with adjustment for high-dimensional propensity scores at baseline. The overall effect across sites will then be estimated using meta-analytic methods.

Eligibility Criteria:
Inclusion Criteria:

* A first prescription of an antidepressant of the SNRI or SSRI class of any dose between January 1, 1997 and March 31, 2010.

Exclusion Criteria:

* They were \<12 years old at the time of cohort entry.
* They had less than 1 year of information in the database prior to the date of cohort entry.
* They had a prescription of an SNRI or SSRI in the year before the date of cohort entry.
* They had a prescription for both an SNRI and an SSRI on the day of cohort entry.
* They had a history of chronic kidney disease (including kidney transplantation and dialysis) or AKI in the year preceding cohort entry.
* The subject was previously included in the cohort.
Effects of Intranasal Oxytocin on Emotion Regulation

The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.

In the present study, the investigators plan to conduct a between-subject, double-blind, placebo-controlled experiment to investigate the effects of oxytocin on neural, physiological and behavior activity related to emotion regulation. The emotion regulation ability will be assessed by emotional go-nogo task and cognitive reappraisal task. The neural activity will be explored by functional magnetic resonance imaging (fMRI). And the investigators will record participants' heart rate during fMRI to investigate the effects of oxytocin on heart rate variability in emotion regulation process.

All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration, including Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS), Autism Spectrum Quotient (ASQ), Empathy Quotient (EQ), Interpersonal Reactivity Index (IRI), Action Control Scale (ACS), Emotion Regulation Questionnaire (ERQ), Berkley Expressivity Questionnaire (BEQ), and so on.

Eligibility Criteria:
Inclusion Criteria:

* healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria:

* history of head injury;
* claustrophobia;
* medical or psychiatric illness.
Using Hypnosis to Help Children Undergoing a Difficult Medical Procedure

This study examined whether a hypnosis intervention, compared to standard care, could help reduce distress and pain for children undergoing an invasive medical procedure.


Eligibility Criteria:
Inclusion Criteria:

* The child: (1) was scheduled for an upcoming VCUG ; (2) must have undergone at least one previous VCUG; (3) was at least 4 years of age at the time of the previous VCUG; (4) experienced distress during the previous VCUG; and (5) both child and participating parent were English speaking.

Exclusion Criteria:

* Not meeting any of the above criteria.
Clinical Research of Femtosecond Laser-Assisted Cataract Surgery

Since femtosecond laser was approved for cataract surgery by FDA in 2010, femtosecond laser assisted cataract surgery (FLACS) has demonstrated high precision of capsulotomy, reduced phacoemulsification power and time, and comparable refractive outcome in clinic.

It is still unknown whether there are toxic substances produced due to photochemical or high-energy physical effect of femtosecond laser during FLACS.

Phacoemulsification is one of the main surgical procedures for cataract surgery owing to the advantages of small incisions and rapid recovery. However, the surgical outcome of phacoemulsification can be negatively affected due to the problem of accuracy and repeatability for capsulorhexis, and the corneal endothelial cell damage by ultrasound energy.To overcome those problems from the phacoemulsification, femtosecond laser-assisted cataract surgery (FLACS) had been used in the past few years and showed unique advantages.

The purpose of this study is to investigate the preliminary clinical outcomes of femtosecond laser-assisted cataract surgery.This prospective comparative study enrolled consecutive patients,will be randomly assigned to trial group underwent FLACS and control group underwent conventional cataract surgery.

The phacoemulsification time, energy, and complications during operation were recorded.

The anterior capsule and aqueous humor were collected. Morphology of the cutting edge and cells of anterior capsule was assessed by light microscopy. The proteins in the aqueous humor were identified by mass spectrometry . Electrolyte in the aqueous humor was detected by a chemistry analyzer. Postoperative refraction at 1 day, 1 week, 1 and 3 months, the capsulorhexis size and corneal endothelial density at 1 and 3 months were also measured.

Eligibility Criteria:
Inclusion Criteria:

1. normal cornea
2. dilated pupillary diameter greater than 6mm
3. no local or systemic contraindications to cataract surgery

Exclusion Criteria:

1. corneal pathological changes
2. glaucoma
3. ocular inflammation
4. previous ocular trauma or surgery
Changes of Low Anterior Resection Syndrome and Balance Ability in Patients with Rectal Cancer.

The purposes of this study are to explore the trajectory of symptom distress and balance ability in patients with rectal cancer.


Eligibility Criteria:
Inclusion Criteria:

1. Newly diagnosed rectal cancer
2. Patients already know their condition.
3. Aged 20 years and older.
4. Consciously communicate in Mandarin or Taiwanese.
5. Agreed with the interview and had signed the permit.

Exclusion Criteria:

1. Recurrent rectal cancer.
2. KPS of patients less than 80
Yoga and Aerobic Exercise Effects on Cognition

The purpose of this acute randomized control study is to assess the feasibility of a low-to-moderate intensity Yoga intervention (i.e. sun salutations), and examine its effect on cognitive functioning, compared to engaging in aerobic activity or seated rest. Participants will include individuals who are currently experiencing symptoms of psychosocial stress or general anxiety.

Eligible participants will be randomized to one of three groups: 1. Sun salutations (Yoga), 2. Aerobic exercise (walking on a treadmill), 3. Seated rest (watching educational videos). Each activity will be 30 minutes in duration. Immediately before and after the 30 minute intervention, participants will undergo psychosocial and cognitive assessments. Prior to the intervention, participant's physical activity will be tracked for one week, via a consumer grade accelerometer.

Baseline and post-intervention testing will include a cognitive battery, psychosocial questionnaires, flexibility testing and physiological measures.

Eligibility Criteria:
Inclusion Criteria:

* Anyone between the ages of 18-45 years
* Anyone with a score of 3 or higher on the Generalized Anxiety Disorder symptom checklist of the Diagnostic and Statistical Manual 5. That is, anyone meeting 3 or more symptoms, on more days of the week than not, for the past 6 months:

  1. Restlessness, feeling keyed up or on edge. 2. Being easily fatigued. 3. Difficulty concentrating or mind going blank. 4. Irritability. 5. Muscle tension. 6. Sleep disturbance (difficulty falling or staying asleep, or restless, unsatisfying sleep).
* Ability to exercise at moderate to vigorous activity levels (defined as 50%-75% of the adjusted age-predicted maximum heart rate)
* Access to a smartphone and willingness to allow research staff to install a mobile activity tracker application (and space to allow for installation)
* Willingness to be randomized into one of three groups

Exclusion Criteria:

* Anyone who is physically active (≥30 minutes, 2 or more times/week, for the last 3 months) and/or a regular practitioner of Yoga or mind-body activities (≥30 minutes, 2 or more times/week, for the last 3 months).
* Anyone with serious chronic medical conditions that would preclude them from participating without a physician present, or anyone with a risk of seizure, or anyone having psychiatric and/or neurological disorders.
* Anyone who does not consent to wearing the Fitbit, or does not have a smartphone that allows us to download an app on their phone.
* Pregnant women.
* Anyone incapable of performing the following movements at a moderate intensity- sitting, standing, kicking, pulling, pushing, bending one's elbows, bending the body forward, bending one's knees, lying down and getting up.
* Anyone with blood pressure of 200/105 or more, and anyone who scores 1 or more on the Physical Activity Readiness Questionnaire
* Anyone refusing or unwilling to be randomized into either of the conditions.