cyrilzakka/clinical-trials huggingface dataset:
Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral Sclerosis

The investigators hypothesize a relevant impact of cognitive status over gait performance in patients with amyotrophic lateral sclerosis (ALS), contributing to poor mobility and representing a relevant risk for falls. The present observational, cross-sectional study on ambulatory patients with ALS will evaluate gait performance using different sets of dual-task conditions to demonstrate the importance of cognitive aspects in rehabilitation programs for these patients. The dual-task conditions to be assessed during gait performance will include: counting backwards by 3 (executive simple task); counting backwards by 7 (executive complex task); mnemonic recall of the Rey's Auditory Verbal Learning Test (RAVLT). Patients' performance will be compared with a group of healthy controls with similar age and sex distribution in order to highlight the specific effects of the disease.


Eligibility Criteria:
Patient inclusion criteria:

* Age ≥ 18 years;
* Clinical diagnosis of ALS or other MND phenotype;
* Able to walk unassisted for at least 1 minute consecutively;
* Oral and written informed consent to study participation.

Healthy control inclusion criteria:

1. Age ≥ 18 years;
2. Age and sex distribution similar to patients (age range: mean age of patients years ± 15 years);
3. Able to walk unassisted for at least 1 minute consecutively;
4. Oral and written informed consent to study participation.

Exclusion Criteria

An individual (either patient or healthy control) who meets any of the following criteria will be excluded from participation in this study:

1. Diagnosis of dementia;
2. Medical conditions or substance abuse that could interfere with cognition;
3. Any (other) major systemic, psychiatric, neurological, visual, and musculoskeletal disturbances or other causes of walking inability.
Anesthetists After the Pandemic in the Eyes of the Public

Anaesthesia and anesthesiologist from the very beginning has obtained "Behind the screen" role. This is of great concern as the field of Anesthesiology has expanded its services to various specialities like intensive care, postoperative pain management, labour analgesia, accident and trauma management, casualty etc. the role assigned to the anesthesiologist remains inaccurate even during COVID 19 pandemic.

The aim of this study was to evaluate general publics' perception about anesthesiologist\& anesthesia in operating and especially intensive care units during COVID 19 pandemic.

Method: A questionnaire consisting of 27 questions was asked to fill by the general population via the social media. The questionnaire consists of two parts: The first part includes demographic data such as age, gender, education level, occupation; the second part includes the questions about anesthesia experience and knowledge.

Eligibility Criteria:
Inclusion Criteria:

- Subjects older than 16 years of age and not working in any health sector will be included in the study.

Exclusion Criteria:

* if she/he doesn't want to join
Effects of Varied Estrogen Doses on Endometrial Receptivity

This study will help determine the effect of varied estradiol levels on the uterine lining in healthy humans that are not undergoing a stimulated in vitro fertilization (IVF) cycle.

Volunteers who wish to participate in the study, will undergo a diagnostic and screening phase to determine their eligibility. Once eligibility is determined, participants will undergo three, separate "endometrial preparatory cycles". These cycles will consist of estrogen supplementation to mimic normal, above normal, and highly elevated estradiol levels. Once supplementation is complete uterine procedures will be done to hopefully determine the effects of the estrogen levels on the uterine lining. Subcutaneous leuprolide injections, intramuscular estrogen, and progesterone injections will be used to mimic the levels needed. Blood draws will monitor the needed estradiol and progesterone levels during the injection phase of the cycle. Once the injection phase is complete, transvaginal ultrasound, uterine aspiration, and endometrial biopsy will be done.

Eligibility Criteria:
Inclusion Criteria:

* Regular menstrual cycles
* Age 18-50
* Normal Baseline ultrasound
* No intra-uterine procedures in prior 90 days

Exclusion Criteria:

* Any contraindications to undergoing estrogen stimulation of the endometrium
* Age ≥35 years and smoking ≥15 cigarettes per day
* Multiple risk factors for arterial cardiovascular disease (smoking, diabetes, and hypertension)
* Hypertension (systolic ≥140 mmHg or diastolic ≥90 mmHg)
* Venous thromboembolism (current or history of)
* Known thrombogenic mutations
* Known ischemic heart disease
* History of stroke
* Complicated valvular heart disease (pulmonary hypertension, risk for atrial fibrillation, history of subacute bacterial endocarditis)
* Systemic lupus erythematosus (positive or unknown antiphospholipid antibodies)
* Migraine with aura at any age
* Breast cancer
* Cirrhosis
* Hepatocellular adenoma or malignant hepatoma
* History of undiagnosed abnormal uterine bleeding.
* Allergic reaction to any study drug
* Known pregnancy or delivery within the past 6 months
* Breastfeeding
* Obesity \>35 kg/m2
A Study of Optical Imaging With Light From Radiotracers in Cancer Patients

The purpose of this study is to test Cerenkov luminescence imaging, which is a different way to take pictures of thyroid cancer and/or any tumors with (existing or suspected) nodal metastases in the neck, supraclavicular, axillary and/or inguinal region.


Eligibility Criteria:
Inclusion Criteria:

* Participant is 18 years of age or old
* Participant must meet one of the following:

  * Patients with thyroid cancer scheduled for thyroid ablation therapy with 131I
  * Patients with any tumors with (existing or suspected) nodal metastases in the neck, supraclavicular, axillary and/or inguinal region who are scheduled to receive a clinical FDG PET/CT scan
  * Patients with metastatic prostate cancer who are schedule for Xofigo therapy with 223Ra
  * Patients scheduled to receive a standard of care 66Ga-DOTA-TATE or \[18f\]-PARPi PET scan in the Nuclear Medicine Clinic
  * Patient undergoing Lu-DOTA TATE treatment in the Nuclear Medicine Clinic

Exclusion Criteria:

* Patients imaged for Cerenkov luminescence are going to be required to be in a darkened enclosure for at least 10 minutes and sit still during image acquisition. Any conditions that would prevent this will exclude the patients. This includes patients who unable to sit in a dark environment, have claustrophobic, inability to sit still for a few minutes
* Any other past medical, physiological or demographic concerns. This includes any patients with skin blemishes that are present at the dermis over the tumor, as these are of particular interest for use of this technique. This also includes open wounds on the area of interest.
Effects of Calamansi on Blood Glucose

It is important to bring the blood glucose levels of those with type 2 diabetes mellitus (T2DM) back to normal levels as this can stop the condition from worsening and prevent other conditions that are related to T2DM from developing. One way to maintain healthy blood glucose level is the use of the glycaemic index (GI), which ranks food according to how the body responds to its carbohydrate content. Low GI foods corresponds to low increase in blood glucose levels. Calamansi is a citrus that is believed not to induce an increase in blood glucose levels. Since beverages from calamansi are available and diabetes is a health concern in the community, it is important to investigate the effect of consuming this drink. Finger prick blood were tested in order to obtain the blood glucose levels for calculating the GI for the calamansi drink.


Eligibility Criteria:
Inclusion Criteria:

* non-smoker
* BMI between 18.5 and 24.99 kg/m2
* waist circumference less than 102 cm
* random blood glucose less than 7.8 mmol/L
* negative urine dipstick result
* not on any medications
* no family history of inherited diseases
* no heart conditions (angina, arrhythmia or heart failure)
* no history of acute medical or surgical event within the past 6 months.

Exclusion Criteria:

* pre-existing conditions such as HIV, hepatitis, inflammatory bowel diseases, diabetes mellitus, kidney disease, blood disorders (such as thalassaemia)
Neoadjuvant Trial of Capecitabine for Axillary Lymph Node Positive Operable Breast Cancer

This randomized phase II trial compared pathologic response rates (pCR) of early breast cancer following neoadjuvant fluorouracil-epirubicin-cyclophosphamide(FEC) and capecitabine-epirubicin-cyclophosphamide (XEC).


Eligibility Criteria:
Inclusion Criteria:

* Females aged 18-70 with histologically proven, core-biopsied, Stage II-III invasive breast cancer
* No distant disease

Exclusion Criteria:

- Inadequate heart or liver or kidney function
Assessment of Utility of accelerateIQ in the Care of Patients Participating in a Pulmonary Rehabilitation Program

The proposed study seeks to assess the performance of continuous biosensor data and machine learning analytics in assessment of health patient status in a pulmonary rehabilitation program.

It is hypothesized that using continuous physiologic biosensor data and machine learning analytics to detect changes in physiology may play a role in managing patients in the pulmonary rehabilitation setting.


Eligibility Criteria:
Inclusion Criteria:

* Male or female, at least 40 years of age;
* Diagnosis of Chronic Obstructive Pulmonary Disease (COPD);
* Enrolled in the study site's 12-week pulmonary rehabilitation program;
* Capable of completing a 6-minute walk test;
* Willing and able to comply with scheduled protocol procedures and follow up;
* Signed and dated informed consent and HIPAA materials indicating that the patient has agreed to participate in this study and has been informed of all pertinent aspects of the trial.

Exclusion Criteria:

* Patient has cognitive or physical limitations that, in the opinion of the investigator, limit the patient's ability to utilize the System as instructed;
* Patient is actively enrolled in another clinical investigation that, in the opinion of the investigator, interferes with or compromises either that patient's ability to participation in this study or the ability for the study to generate results;
* Patients who have implanted defibrillators or pacemakers;
* Patient is allergic to hydrocolloid adhesive;
* Patient does not speak English.
Impact of COVID 19 on Psoriasis Patients

The main objective of this work is to investigate the effect of COVID-19 pandemic on psoriasis patients.

This work is designed as a cross-sectional survey based on a questionnaire directed to Egyptian psoriasis patients.


Eligibility Criteria:
Inclusion Criteria:

* Psoriaisis patients

Exclusion Criteria:

* Children
Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats

Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass grafting(CABG) patients. Patients who were eligible received either hypertonic lactate solution or Ringer's Lactate post-CABG in the ICU when fluid resuscitation was needed.

Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass grafting(CABG) patients. Patients who were eligible received either hypertonic lactate solution or Ringer's Lactate post-CABG observed in the first 12 hours in the ICU when fluid resuscitation was needed.

Eligibility Criteria:
Inclusion Criteria:

* Patients who have given their written informed consent.
* Male or female, aged 18-75 years.
* Post-operative CABG on pump or off pump in ICU.
* Patients who need fluid resuscitation.

Exclusion Criteria:

* Combined operations.
* Need for intra aortic balloon pump (IABP).
* Patients with severe arrhythmia (VT, AF rapid response, heart block).
* Severe hemodynamic imbalance.
* Severe bleeding and/or re-operation.
* Liver dysfunction(SGOT and SGPT 2x normal).
* Renal failure (Creatinine \>2 mg%).
Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC)

Observational, multicentre, retrospective study on patients taken care according to the national guidelines. The objective is to define, after the diagnosis confirmation, the frequency of PD-L1 expression in patients with large-cell lung neuroendocrine carcinoma (NEC), whatever the stage of the disease, and to correlate this parameter to clinical data at the time of diagnosis, therapeutic response and survival. Large-cell NECs present a bad prognostic and there is no evidence of treatment for these patients with advanced disease in second ligne of treatment at that time. To demonstrate the PD-L1 expression in this type of cancer might have a major therapeutic impact in a close future to access immunotherapies.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged \> or = 18 years
* Diagnosis of Large-cell NEC confirmed by centralised reading
* Tumoral materials available and readable for PD-L1 labeling

Exclusion Criteria:

* Other type of Lung cancers
* Tumoral material not available or not readable for centralised reading
* Tumoral material not available or not readable for PD-L1 labeling
ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy

Evaluate the feasibility of using a chatbot combined with continuous activity monitoring to proactively identify, appropriately triage and help manage patients' symptoms during cancer treatment Determine whether such an early outpatient clinic-based intervention can decrease rates of excess triage visits

Correlate changes in activity and early symptom management to emergency department visits, unplanned inpatient hospitalizations and treatment breaks


Eligibility Criteria:
Inclusion Criteria:

* Adults (age \>18 years) with a diagnosis of a head and neck, lung, gastrointestinal cancer, that are receiving concurrent chemotherapy and radiation treatment.
* Possession of a mobile device that can receive SMS texts and can deliver FitBit data wirelessly
* Ability read and respond in English
* Ability to provide informed consent to participate in the study

Exclusion Criteria:

* Patients who are bed bound at baseline (ECOG 4)
* Patients who rely on a wheelchair for ambulation
Pulmonary Contusion Flail Chest Complex

The study included 20 adult patients presented by multiple fractured ribs (flail segment) with thoracic trauma severity score (TTSS) between 5 and 15. All patients received mid-thoracic epidural analgesia with 0.125% Bupivacaine and 1 μg/ml fentanyl. The patients were ventilated using non-invasive positive pressure ventilation (NIPPV). Follow up arterial blood gases, chest X-ray and CT scan were obtained. Parameters to be recorded: Patient's characteristics and clinical data including pulmonary contusion, number of fractured ribs, pleural involvement, PaO2/FiO2 ratio on admission, weaning outcome, duration of NIPPV, length of stay in ICU (LOS ICU), complications and mortality rate.

20 Patients fulfilling the inclusion criteria were submitted to strapping and packing in the form of dressing and fixing with elastoplast. All patients were ventilated using NIPPV (Engstrom Carestation), which was delivered to the patient through full-face mask and was started with pressure support of 8-12 cmH2O and PEEP of 3-5 cmH2O and gradually increased in 2 cmH2O steps. When patients tolerate FiO2 ≤ 0.5 with pressure support ≤ 8 cmH2O and PEEP ≤ 5 cmH2O for \> 6 consecutive hours, withdrawal from NIPPV was attempted daily in 30 minutes spontaneous breathing trials. Therapy was considered successful if endotracheal intubation was avoided and the patient could be discharged from the ICU. During this period follow up arterial blood gases, chest X-rays and CT scans were obtained.

Eligibility Criteria:
Inclusion Criteria:

* Patients with multiple fractured ribs with flail segment presented by acute respiratory distress that had deteriorated despite effective pain management, their age more than 18 years and less than 70 years, with thoracic trauma severity score (TTSS) between 5 and 15

Exclusion Criteria:

* Patients requiring endotracheal intubation or emergency surgery following admission, severe associated trauma to other systems, respiratory failure caused by neurological disease or asthmatic attack or any contraindication for NIPPV.
Characterization of Visual Characteristics in Allergic Contact Dermatitis Using the Skincam® Tool

Contact dermatitis (CD) is a common inflammatory skin disease, affecting approximately 15-20% of the general population in industrialized countries and ranking first among occupational diseases in many European countries.

The patch test method aims at reproducing the eczematous lesions by applying occlusive patches containing the suspected allergens to the patient's healthy skin. It requires experienced medical staff to read the reaction.

Newtones Technologies society has developed a new tool, the SkinCam®, able to capture high resolution cross and parallel images, allowing a quantification of color and relief of skin.

This study aims to illustrate patch test results, describing skin appearance (color, roughness, shine), using photographs taken by the SkinCam®.

Contact dermatitis (CD) is a common inflammatory skin disease, affecting approximately 15-20% of the general population in industrialized countries and ranking first among occupational diseases in many European countries.

Allergic contact dermatitis (ACD) typically presents as a severe skin inflammation with redness, edema, oozing and crusting. It is characterized by a delayed type IV hypersensitivity response mediated by allergen-specific T cells in sensitized individuals. Current diagnosis relies on clinical investigations by diagnostic patch testing with suspected allergenic chemicals.

The patch test method aims at reproducing the eczematous lesions by applying occlusive patches containing the suspected allergens to the patient's healthy skin. It requires experienced medical staff to read the reaction.

Newtones Technologies society has developed a new tool, the SkinCam®, able to capture high resolution cross and parallel images, allowing a quantification of color and relief of skin.

This study aims to illustrate patch test results, describing skin appearance (color, roughness, shine), using photographs taken by the SkinCam®.

Eligibility Criteria:
Inclusion Criteria:

* Patient, male or female, over 18 years of age
* Patients called for reading patch test, applied 72 or 96 hours ago
* Patients agreeing to have unidentified photographs of patchs tests
* Patient affiliated to or benefiting from a social security regime
* Patient having been informed and not having opposed

Exclusion Criteria:

* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision
* Pregnant woman
Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease

Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is normal they will undergo a second and final scan four weeks later. If abnormal they will undergo two further scans with either nebulized bronchodilator or nebulized saline prior to their second and third scans. Each time they will have repeat lung function tests prior to scanning. We will examine the regional changes in ventilation and perfusion and there relationship to lung function.

As in Brief description

Eligibility Criteria:
Inclusion Criteria:

* FEV1 \< 70% predicted at baseline on spirometry
* significant smoking history or alpha 1 antitrypsin deficiency
* no evidence of current infection or restrictive lung disease

Exclusion Criteria:

* history of other significant respiratory disease
* significant respiratory infection within 6 weeks
* history of significant physical or mental illness rendering them unfit for the study in the opinion of the investigator
* taken part in any other research within the past 12 months, or received exposure to ionizing radiation
Plant-based Ingredient on Post Prandial Glucose in Type II Diabetes

Effects of a plant based ingredient on blood glucose in Type II diabetes patients.

The study is designed to determine the extend to which a plant based ingredient in a food format affects blood glucose responses in untreated Type II diabetes patients.

Eligibility Criteria:
Inclusion Criteria:

* Male and female volunteers with confirmed Type II diabetes not treated with pharmaceutical-based glucose lowering treatment for past three months (controlled solely through diet and exercise);
* Age ≥ 20 and ≤ 65 year at screening;
* Body Mass Index (BMI) between ≥18 and ≤ 32 kg/m2;
* HbA1c ≥48 mmol/mol and ≤53 mmol/mol (≥ 6.5% and ≤ 7.0%). At discretion of the study physician, subjects with HbA1c \>53 mmol/mol and \<58 mmol/mol (\>7.0% and \< 7.5%) controlled solely through diet and exercise are also allowed to participate.

Exclusion Criteria:

* Being an employee of Unilever or research site;
* Chronic smokers, tobacco chewers and drinkers;
* No medication, including vitamins and tonics, except for cholesterol, as determined by the physician;
* Reported weight loss/gain ≥ 10% of body weight in the 6 months preceding screening;
* Allergy to any food or cosmetics;
* If female, not being pregnant or planning pregnancy during the study period;
* If female, lactating or has been lactating for 6 weeks before pre-study investigation and/or during the study period.
Effect of Intake of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement

This study was conducted to investigate the effects of daily supplementation of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement

This study was a 8 weeks, randomized, double-blind, placebo-controlled human trial. 40 subjects were randomly divided into Allium Cepa L. Peel Heated Water Extract or a placebo group. Immunity Enhancement profiles before and after the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Age 19-75 years
* Symptoms of upper respiratory infection at least once within past 12 months

Exclusion Criteria:

* Cardio-cerebrovascular, endocrine, immune, respiratory, musculoskeletal, inflammatory, hematologic, tumorigenic, gastrointestinal diseases, etc.
* Vaccination within past 2 months
* BMI \< 18.5 kg/m2 or 35 kg/m2 ≤ BMI
* Immunity enhancement agents within past one months
* Allergic or hypersensitive to any of the ingredients in the test products
* Antipsychotic drugs therapy within past 3 months
* History of alcoholism or drug abuse
* Participation in any other clinical trials within past 3 months
* Pregnant or lactating women
* Judged ineligible to participate in the trial by the principal investigator