cyrilzakka/clinical-trials huggingface dataset:
Improve SCA Bridge Study

The purpose of the Improve SCA Bridge study is to characterize the care pathway flow of post-acute myocardial infarction (MI) patients as a result of standard assessments of left ventricular ejection fraction (LVEF) in the acute phase (≤14 days post- acute MI) and chronic phase (≥40-90 days post-acute MI).

To determine how many patients are referred for sudden cardiac death (SCD) risk stratification and management, indicated for implantable cardioverter defibrillator (ICD), or cardiac resynchronization therapy- defibrillator (CRT-D) implant, and how many receive such devices within 12 months of experiencing an MI.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 and above (or meet age requirements per local law)
* Patients who have an acute Myocardial Infarction (MI) (STEMI or Non-STEMI) ≤ 30 days of study enrollment and have a LVEF \<50% measurement ≤ 14 days post-acute MI
* Willing and able to give valid Informed Consent

Exclusion Criteria:

* Patient has previously received or currently implanted with an ICD or CRT-D
* Patient has any contraindication for ICD/CRT-D
* Patient has a life expectancy of less than 12 months
* Patient who has had an EP referral within the last 12 months
* Any exclusion criteria required by local law (e.g. pregnancy, breast feeding etc.)
* Patient is unable (e.g. mental disorder) or unwilling to be compliant with the responsibilities as specified in the informed consent form.
* Patient is enrolled in a concurrent study that has not been approved for concurrent enrollment by the Medtronic Clinical Trial Leader
Fasting-mimicking Diet and Immunosenescence

The objective of this study is to test a Fasting-Mimicking Diet (FMD) for its efficacy on improving immune response to flu vaccination in an older adult population (50-75 years of age).

This is a randomized clinical trial to test the safety and efficacy of the fasting-mimicking diet (FMD) in an elderly population (50-75 years of age) receiving their annual influenza vaccination. The study will include two arms: Control (normal diet) and FMD (2 cycles of 5-day fasting-mimicking diet within two months). Participants both arms will receive the standard influenza vaccine.The primary endpoint is anti-influenza antibody titers measured 4 weeks after flu vaccination. Secondary endpoints include: (1) body composition changes, measured as BMI, waist to hip ratio; (2) physiological changes, measured as blood chemistry and motor performance; (3) health outcomes, measured by SF-36 Health survey, dry eye surveys and flu incidents within 12 months of vaccination.

Eligibility Criteria:
Inclusion Criteria:

* Ability and willingness to provide written informed consent;
* Ability and willingness to undergo 2 cycles of a 5-day dietary regimen;
* Ability and willingness to provide blood samples via venipuncture;
* Seeking to get a seasonal influenza vaccine.

Exclusion Criteria:

Concomitant medications

* Received flu (influenza) shot for the flu season;
* Receiving immunosuppressive therapy (i.e., oral prednisone in doses \> 10 mg daily);
* On immunosuppressive drugs for cancer or rheumatologic therapy;
* Receiving insulin or octreotide;
* On hypertension medication. The subject must obtain the treating doctor's approval prior to beginning the study.

Safety-based exclusions:

* Hemoglobin \< 9.0 g/dL;
* White blood cell count \< 3,500/mm\^3;
* Neutrophil count \< 2,000/mm\^3,
* Platelet count \< 125,000/mm\^3;
* Medical conditions that are incompatible with the dietary intervention ;
* Medical conditions that are incompatible with the flu vaccination;
* Pregnant or nursing female;
* Alcohol dependency;
Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans

The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.


Eligibility Criteria:
Inclusion Criteria:

* Self-identify as African American/Black
* Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet
* Age 18-40

Exclusion Criteria:

* History of smoking within 2 years or being a current smoker
* Taking vasoactive medications
* Having overt cardiovascular, metabolic, or neurological disease
* Pregnant individuals
Dexamethasone as an Adjuvant in Supraclavicular Block

The use of dexamethasone perineurally along with local anesthetic has been shown to improve the duration of analgesia .

Acute postoperative pain can be effectively controlled with the use of peripheral nerve blocks. Use of additives further prolongs the duration of analgesia For upper limb surgeries below shoulder joint, the brachial plexus block using supraclavicular approach introduced by Kulenkampff has gained popularity. Supraclavicular approach to brachial plexus block is useful for procedures done at or below the level of elbow.

This technique involves the deposition of local anesthetic near the brachial plexus approached from immediately above the clavicle. Brachial plexus is formed by ventral rami of C5, C6, C7, C8, and T1 which forms the roots.These then continue distally to form trunks, divisions, cords,and branches Local anesthetics used alone in supraclavicular block provide analgesia for 4-8 h.

The use of dexamethasone perineurally along with local anesthetic has been shown to improve the duration of analgesia. Intravenous dexamethasone is also useful in attenuating the postoperative need for analgesics in different clinical settings even in the absence of any nerve blocks.

Hence, it is logical to compare the duration of analgesia with the use of dexamethasone in the setting of supraclavicular brachial plexus block, dexamethasone given either perineurally or intravenously.

Eligibility Criteria:
Inclusion Criteria:

* 1. Patients between 18 and 60 years of age 2. Both male and female gender 3. ASA physical status Classes I and II patients 4. Patients posted for upper limb surgery below shoulder.

Exclusion Criteria:

* 1. Patient refusal 2. Patients with bleeding disorders and those on anticoagulant therapy 3. History of allergy to local anesthetics 4. Infection at the site of block 5. Neuro deficit involving brachial plexus 6. Pregnant women 7. Patients with psychiatric behavior 8. ASA physical status Classes III and IV patients
Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies (ECORAS2023)

The study aims to evaluate the prevalence of thyroid disease, particularly with autoimmune pathogenesis (isolated hyperthyrotropinemia, hyperthyroidism, hypothyroidism, thyroid nodules) and/or morphostructural abnormalities of the thyroid gland in patients with RASopathy genetically confirmed by NGS technique (analysis of the genes: BRAF, CBL, HRAS, KRAS, LZTR1, MAP2K1, MAP2K2, MRAS, NRAS, PPP1CB, PTPN11, RAF1, RIT1, RRAS2, SHOC2, SOS1, SOS2) and to compare the data obtained in our sample with those of the general population.

The secondary aim of the study is to evaluate the association between vitamin D deficiency and/or other abnormalities of bone metabolism and thyroid disease and/or morphostructural anomalies of the thyroid gland in patients with RASopathy.

All patients will undergo blood sampling aimed at studying thyroid function and autoimmunity (TSH, fT3, fT4, anti-TPO, anti-TG, anti-TSH receptor antibodies) and biomarkers of bone metabolism (calcium, phosphorus, ALP isoenzyme bone, PTH, osteocalcin, vitamin D) and a systematic color Doppler ultrasound examination of the thyroid gland in order to evaluate dimensions, echostructure and echogenicity of the thyroid parenchyma, presence of nodular lesions, vascularization and laterocervical lymphadenopathy.

Eligibility Criteria:
Inclusion Criteria:

* Genetically confirmed RASopathy
* Age 3-25 years

Exclusion Criteria:

* Previous radiotherapy treatments, known exposure to ionizing radiation
* Iodine deficiency
* Use of iodine-based compounds or drugs that interfere with thyroid function
* Congenital hypothyroidism/hyperthyroidism
* Severe obesity with metabolic complications
Effect of Strength Training for Chronic Low Back Pain Patients (IRMA20)

Low back pain (LBP) is common in the population and has great socioeconomic consequences for societies across Europe and the United States. About a third of working-age adults have frequent LBP, and for about 10% the pain becomes chronic with consequences for work and leisure activities. A Cochrane review from April 2017 concluded that physical exercise is an intervention with few adverse events and positive outcomes on pain and function in adults with chronic pain. However, when scrutinizing the specific studies of the review there are large differences in adherence to the exercise interventions and consequently in the results obtained. Thus, there is a need for simple exercises that the patients can easily adhere to.


Eligibility Criteria:
Inclusion Criteria:

* Non-specific Chronic low back pain patient (more than 3 months) at the hospital Arnau de Vilanova

Exclusion Criteria:

* Spine surgery
* neurologic or psyquiatric disorders
* Low back traumastism
* Recent participation in a similar training program
Renal Sympathetic Modification in Patients With Metabolic Syndrome

The purpose of this study is to observe the incident of composite cardiovascular events after renal sympathetic modification using THERMOCOOL® catheter in patients with metabolic syndrome, and evaluate safety and efficacy of the intervention.

Metabolic syndrome is combination risk factors of serial cardiovascular and metabolic disease, included central obesity, insulin resistance, dyslipidemia, and hypertension. Basic studies suggested that sympathetic nerves over activity played an important role in the development and perpetuation of metabolic syndrome. Clinical therapies occurred by complication treatment and therapeutic life-style changes. Present study of renal ablation for sympathetic modification shows a new method to decrease sympathetic nerves activity. We assume that modifying renal sympathetic activity by ablation is effective and safe in treatment of metabolic syndrome. This trial is going to recruit 200 patients (Ablation group VS Control group = 1:1) with a follow-up duration of 3 years. Patients in ablation group will receive additional necessary medications besides expectant intervention, and patients in control group will receive appropriate medications only. We aim to observe the incident of composite cardiovascular events after renal sympathetic modification using THERMOCOOL® catheter in patients with hypertension, and evaluate safety and efficacy of the intervention.

Eligibility Criteria:
Inclusion Criteria:

* ≥ 18 years old, and ≤ 75 years old of age
* abnormal metabolism: 1) body mass index (BMI) of ≥ 25 kg/m2; 2) total triglyceride (TG) of ≥ 1.70mmol/l (150mg/dl); 3) high density lipoprotein- cholesterol (HDL-C) of male \<0.91mmol/l (35mg/dl), and of female \<1.01mmol/l (39mg/dl); 4)fasting blood glucose 6.1mmol/l (110mg/dl), or glucose tolerance test of 2 hours ≥ 7.8 mmol/l (140mg/dl); 5), or history of diabetes mellitus
* estimated glomerular filtration rate (eGFR) of ≥ 45mL/min
* is competent and willing to provide written, informed consent to participate in this clinical study

Exclusion Criteria:

* secondary hypertension
* type 1 diabetes mellitus
* estimated glomerular filtration rate (eGFR) of \< 45mL/min
* has the history of renal restenosis or renal stents implantation
* has experienced AMI (old myocardial infarction is not excluded), unstable angina pectoris, cerebrovascular accidents, and alimentary tract hemorrhage within 3 months
* patients with sick sinus syndrome
* pregnant women
* mental disorders
* patients that have allergy to contrast agent
* patients that do not go with follow-up
* others such as researcher considers it is not appropriate to be included into the study
House Dust Mite Treatment of Asthma. The MITRA Trial House Dust Mite Treatment of Asthma

The purpose of this trial is to investigate if treatment with house dust mite allergen immunotherapy tablet can reduce the risk of asthma exacerbation in subjects with house dust mite induced asthma.


Eligibility Criteria:
Key Inclusion Criteria:

* A clinical relevant history consistent with house dust mite induced asthma of at least 1 year prior to trial entry.
* Use of an appropriate amount of inhaled corticosteroid for the control of asthma symptoms.
* Documented reversible airway obstruction.
* Suitable level of asthma control.
* FEV1 ≥ 70% of predicted value.
* Positive Skin Prick Test response to Der pte and/or Der far.
* Positive specific IgE against Der pte and/or Der far (≥ IgE Class 2; ≥ 0.70 KU/L).

Key Exclusion Criteria:

* A clinical history of persistent allergic asthma or rhinitis caused by an allergen to which the subject is regularly exposed and sensitised (except house dust mites).
* A clinical history of intermittent allergic asthma or rhinitis if the seasonal allergen is causing symptoms in the period from October to March.
* Any clinically relevant chronic disease.
Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions

Determine the pharmacokinetics and optimize study design for subsequent studies with morphine sulfate tablets and solution.


Eligibility Criteria:
Inclusion Criteria:

* No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening.

Exclusion Criteria:

* Positive test for HIV, Hepatitis B, or Hepatitis C.
* Treatment with known enzyme altering drugs.
* History of allergic or adverse response to morphine sulfate or any comparable or similar product.
Vibration Response Imaging in Healthy Subjects

The primary purpose is to test intersubject variability and establish the qualitative features of normal VRI images and the range of normality of the VRI quantitative lung data values that may be used to differentiate normal from abnormal breath sound distribution. Our hypothesis was that VRI breath sound images of healthy subjects are similar in a qualitative and quantitative manner.

Computerized analyses have shown that normal lung sounds have distinctive characteristic that can be differentiated from abnormal lung sounds.However, technical issues and complicated display modes have restricted the use of computerized lung sound analyses in the clinical environment.

The VRI provides dynamic gray-scale images and quantitative lung data showing the breath sound distribution of healthy individuals. Typical features that are discerned by trained raters and quantitative lung data may serve as a reference for comparison to abnormal breath sound images.

Eligibility Criteria:
Inclusion Criteria:

* Able and willing to read, understands, and provides written Informed Consent;
* Male or Female in the age range of 18-85 years;
* Subject is healthy and has not exhibited symptoms of acute respiratory tract disease for the past two months;
* Subject has normal chest X-ray and normal lung function during the past 6 months that were judged stable;
* BMI \> 21.

Exclusion Criteria:

* Subject has a history of a chronic condition that affects the lungs or heart (e.g.chronic obstructive pulmonary disease, asthma, congestive heart failure) or is suspected of having such a condition;
* Subject has a chest cage deformation;
* Subject has spine deformation (including severe scoliosis);
* Subject is Hirsute;
* Subject has a skin lesion (potentially contagious) on the back;
* Subject has a cardiac pacemaker or implantable defibrillator;
Assessing the Histological Quality of Biopsy Samples Obtained With Multibite Forceps

Biopsies are routinely taken during endoscopy and colonoscopy in order to facilitate histological analysis of various disease processes. The current practice of obtaining biopsies involves taking a maximum of two biopsies at a single time (ie. with a single pass). When investigating certain diseases, such as celiac disease, there is a need to obtain several biopsies (sometimes greater than 6) and the current practice of taking one to two biopsies at a time can lengthen endoscopy time. This study investigates a new approved multiple bite forceps that has the ability to retrieve six biopsies during a single pass which could reduce endoscopy time and improve diagnostic yield. This study will assess the histological quality of multiple biopsies when taken with the multiple bite forceps compared to the standard double bite forceps. This multiple bite forcep is approved for clinical use in Canada.

This will be a prospective randomized noninferiority study that will take place at Hotel Dieu Hospital. Based on a statistical power calculation, a total of 100 patients are required for enrollment. Enrollment will take place at the outpatient endoscopy suite at Hotel Dieu Hospital. Patients will be reviewed for eligibility as per the inclusion and exclusion criteria and those deemed eligible will consent for participation. Members of the research time will attempt to contact patients two to three weeks prior to their schedule endoscopy for consent. If unable to reach them after two attempts, they will then be consented for their participation during the day of their endoscopy at Hotel Dieu Hospital. Once enrolled in the study, each patient will be randomly allocated to one of two groups (group A and group B) using a computer randomizer generator. The aim is to have equal numbers in both groups (ie. 50 patients in each group). Participants in group A will have their biopsies during endoscopy taken with the conventional double bite forceps. On the other hand, participants in group B will have their biopsies taken with the multiple bite forceps. Each patient in both groups will have at least six biopsies taken. In both groups, biopsies will be taken for assessment of H. pylori and/or celiac disease. Patients recruited will be those who would require these biopsies to be taken regardless of this study. The samples will be sent to pathology where two independent expert gastrointestinal pathologists will examine the slides and grade each specimen using a five-point scale. The overall histological score given to samples will then be assessed to compare those retrieved with the multiple bite forceps and conventional forceps.

Eligibility Criteria:
Inclusion Criteria:

* Patients who were referred for outpatient upper endoscopy at Hotel Dieu Hospital requiring biopsies to investigate for celiac disease or H. Pylori infection.

Exclusion Criteria:

* Patients with clinical or endoscopic evidence of gastric mucosal atrophy.
Screening for Abdominal Aortic Aneurysm Using a Portable Transthoracic Echocardiography Among Patients With Acute Coronary Syndrome

The prevalence of Abdominal Aortic Aneurysm among 65 years old individuals worldwide is 1-2%. when diagnosis is confirmed by abdominal Ultrasound the prevalence is 5.5% in men and 1% in women.

As abdominal aortic aneurysm and coronary heart disease share common risk factors, patients with acute coronary syndrome represent a high risk population in which screening for another atherosclerotic site is recommended.

Patients admitted for ACS undergo routinely TTE. during the same study, TTE may offer the opportunity to evaluate the cardiac morphology and function and to screen for Abdominal Aortic aneurysm. It was reported by different studies that the Sensitivity of this technique was between 91-96% for AAA screening.

In addition, this method is cheap, available and requires only 2-3 minutes to be added to the standard TTE.

we plan to examine patients admitted with ACS in our Intensive Care Unit for screening AAA by TTE in subcostal views in addition to the standard TTE examination.


Eligibility Criteria:
Inclusion Criteria:

* patients over 65 years old with ACS. patients capable of reading, understanding and signing informed concent

Exclusion Criteria:

* suboptimal TTE windows
Influence of Gender Difference on Knee Proprioception in Non-Specific Low Back Pain Among Young Adults

the aim of the study is to investigate the impact of gender difference on knee proprioception among non specific low back pain young adults.

Low back pain (LBP) is one of the most common musculoskeletal disorders and the leading causes of disability and work absence globally. LBP notonly causes individual suffering, but also a heavy burden to the society. Despite this, up to 85% patients with LBP cannot be clearly diagnosed and are classified as non-specific LBP (NSLBP). Proprioception plays an important role in the planning of precise and coordinated movements, in maintaining balance and controlling body posture. It also exerts its influence on motor learning and re-education. Proprioception deficit has been identified in people with LBP and it has been suggested that these deficits might be associated with causes and mechanisms of LBP. Although the local investigation of proprioception is important, the proprioceptive deficits due to LBP may not be restricted only to the lumbar region. Anatomical and biomechanical associations between the knee and lower back segments imply that the knee might be adversely affected in patients with LBP.

there is a gap in the literature concerning sex differences in the knee joint proprioception. Although biomechanical and hormonal differences between males and females are suspected to be responsible for increasing this incidence.

Eligibility Criteria:
Inclusion Criteria:

1. Forty-one Patients from each gender participated in the study.
2. Subject's age ranged from 18-26 years old, with Body Mass Index (BMI) less than 30Kg/m2
3. The dominant knees of the subjects (defined as the leg used for kicking) are tested.
4. Pain between three and eight using numerical pain rating scale NPRS, and Oswestry Disability Index score less than 20.
5. All the subjects sign an informed consent form. 6. able to comprehend and follow the examiner's instructions.

Exclusion Criteria:

1. limitation of active and passive knee joint motion.
2. clinical signs of an impairment or abnormality in the knee (such as abnormal range of motion, muscle weakness, or malalignment).
3. injury to the knee that required medical attention.
4. current pain in the knee or previous surgery on the knee.
5. not able to understand and follow the commands of the examiner.