cyrilzakka/clinical-trials huggingface dataset:
Early Onset and Familial Gastric Cancer Registry

The purpose of this study is to establish a gastric cancer registry. A registry is a database of information. With the registry, we can learn more about the genetic causes of gastric cancer in order to develop better methods of early diagnosis, prevention, and treatment of gastric cancers. As part of this study, you will be asked to join a registry of families who are affected with various forms of gastric cancer. These registries are important because they may help physicians better manage gastric cancer now and in the future. Participating in the Early Onset and Familial Gastric Cancer Registry can also be educational for families, since it will provide important information to patients, families, and physicians. All of this will help to further our understanding of genetic causes of gastric cancer and eventually, help determine better ways to diagnose, treat, and survey patients with gastric cancer and people who may have a higher risk for gastric cancer.


Eligibility Criteria:
Inclusion Criteria:

Patient/Relative Cohort:

Must meet one or more criteria below:

1. A person with a diagnosis of gastric or gastroesophageal junction (GEJ) adenocarcinoma confirmed at the treating institution.
2. A person without gastric or GEJ adenocarcinoma who has or had a first degree relative eligible for a High Risk Genetic sub-group (EOGC/FGC).

   1. Early Onset Gastric Cancer - diagnosis of gastric cancer before the age of 50 without a family history of the disease.
   2. Familial Gastric Cancer - having a family history of gastric cancer as defined as one first degree relative or 2 second degree relatives.
3. A person without gastric or GEJ adenocarcinoma who has a personal family history of a genetic mutation associated with the development of gastric or GEJ adenocarcinoma (i.e. family history of CDH1 mutation).

II. Must be willing to provide a blood sample for germline DNA. These individuals will sign the "Patient/Relative Consent". Following enrollment, we will assign individuals to the appropriate High Genetic Risk or Low Genetic Risk groups based on the age of diagnosis and their family history.

Subject Exclusion Criteria

Patients are ineligible for the study if they:

* Have any condition, which in the opinion of the primary MSK clinician or investigators precludes their ability to provide informed consent.
* Relatives of patients that are not eligible for the High Genetic Risk Cohorts who are less than 18 years of age are excluded.
* Relatives of patients eligible for the High Genetic Risk Cohorts who do not have a proband available to join the study are excluded. (Unless there is a known CDH1 mutation in the family).
Efficacy of Prolotherapy and Hydrodilatation for Frozen Shoulder

Objective: To determine whether ultrasound-guided Intra-Articular Hypertonic Dextrose and hydrodilatation improves pain and function in patients with frozen shoulder(FS)

Setting: a medical center hospital. Participants: Subjects with primary FS with shoulder pain more than 3 months. Interventions: Participants randomly be assigned into A and B group: group A received ultrasound-guided hydrodilatation with hypertonic Dextrose with a mixture of 2mL of 50%, 1mL of 2% lidocaine, and 6ml normative saline ; group B : ultrasound-guided hydrodilatation with 9 mL of normative saline and 1 mL of 2% lidocaine.

Main Outcome Measures: The primary outcome measure was the Shoulder Pain and Disability Index score. Secondary outcomes were the VAS of shoulder pain level, muscle power and angles of shoulder passive range of motion, including flexion, abduction, extension, external rotation, and internal rotation at pretreatment and weeks 2, 4, 8, 12 and 24 of post-treatment.

Eligibility Criteria:
Participants diagnosed with primary FS who had experienced shoulder pain for more than 6 months and a reduction \> 30° in passive ROM of the affected shoulder in at least two directions (forward flexion, abduction, or external rotation) compared with the contralateral side were evaluated for eligibility. 23 Subjects with any degree of tear or calcified tendinitis of rotator cuff tendons, previous shoulder surgery, previous intra-articular injection for the affected shoulder within 3 months of the study; or any secondary FS caused by metabolic, rheumatic, infectious arthritis, stroke, tumor, shoulder fracture/dislocation, or acute cervical radiculopathy were excluded. 23

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Aldosterone Blockade to Prevent Myocardial Remodeling In Patients With Controlled Essential Hypertension

The goal of this project is to investigate the effects that the addition of aldosterone blockade with eplerenone will have on the progression of diastolic dysfunction in patients with controlled essential hypertension.

The purpose of this project is to determine if eplerenone, an aldosterone blocker, prevents remodelling of the heart in patients with controlled essential hypertension, defined as having a blood pressure of equal to or less than 130/80 in diabetics and equal to or less than 140/90 in non-diabetics. This study will investigate if the addition of 25 milligrams of eplerenone daily to a subject's hypertension medication regimen will prevent the progression or development of diastolic dysfunction. Echocardiography will be used to measure the changes in heart structure of subjects receiving eplerenone versus subjects receiving placebo (a drug that may resemble the study drug but contains no active ingredient). Approximately 30 subjects will take part in this study.

Eligibility Criteria:
Inclusion Criteria:

* Treated and controlled hypertension
* Less than 140/90 in non-diabetics
* Less than 130/80 in diabetics

Exclusion Criteria:

* currently receiving an aldosterone blocker
* clinical evidence of congestive heart failure
* prior myocardial infarction
* renal dysfunction with a creatinine clearance of less than 40ml/min
* serum potassium \> 5.5meq/L at initiation
* concomitant use of a medication that inhibits the CYP3A4 enzyme (ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir)
Pain After Buffered Vs Non Buffered Articaine

Pain after buffered versus non buffered articaine.


Eligibility Criteria:
Inclusion Criteria:

* Males and females, age- 18 to 60 yrs.
* Medically free.
* Need a dental treatment in the upper anterior region.

Exclusion Criteria:

* Periodontally affected teeth.
* Radiographic bone loss.
* Upnormal length of the teeth.
Evaluation of Fatigue Severity, Mood, and Quality of Life in Post-Polio Syndrome

The aim of this study is to investigate the differences in the severity of fatigue, impact on quality of life, and mood between individuals with post-polio syndrome and healthy volunteer groups. Additionally, the interrelationships of these parameters within the post-polio syndrome patient group will be examined. The goal is to raise awareness during the follow-up process for individuals with post-polio syndrome by questioning fatigue and mood symptoms, and to facilitate the implementation of necessary precautions.

Our research is designed as a case-control study. 20 patients diagnosed with post-polio syndrome who present to the Istanbul Physical Medicine and Rehabilitation Training and Research Hospital clinics and 20 healthy volunteers will be included in the study. The sociodemographic data of patients and volunteers, such as age, gender, height, weight, body mass index, education level, and occupation, will be recorded. The age at which polio was contracted, the time elapsed since polio, and any accompanying illnesses will be documented. Additionally, if patients experience new symptoms such as pain, weakness, or fatigue, the severity of these symptoms will be assessed using the Visual Analog Scale. The frequency of falls and the presence of fractures caused by falls, ambulation method, and devices used will be noted. Muscle weakness in the extremities will be identified by applying the Manual Muscle Test through physical examination. Subsequently, the patient's current symptoms related to depression and anxiety will be evaluated using the Hospital Anxiety and Depression Scale (HADS), fatigue level will be assessed using the Fatigue Severity Scale (FSS), and quality of life will be evaluated using the Short Form-36 (SF-36).

Eligibility Criteria:
Inclusion Criteria:

* Individuals aged between 18 and 60 with post-polio syndrome.
* Healthy volunteers aged between 18 and 60

Exclusion Criteria:

* fibromyalgia,
* chronic fatigue syndrome,
* presence of chronic decompensated cardiac, renal, and hepatic insufficiency,
* known psychiatric disorders,
* rheumatological diseases,
* presence of other known neurological diseases,
* use of medications aimed at improving physical performance or alleviating fatigue.
Promoting Physical Activity in Chronic Obstructive Pulmonary Disease (COPD) Through New Technology and Health Coaching

The objective of this project is to validate the proposed smartphone-based activity monitor and to test its use for Motivational Interviewing based counseling for physical activity in Chronic Obstructive Pulmonary Disease (COPD).


Eligibility Criteria:
Inclusion Criteria:

* Men and women age 40 years and older
* Current or former smoker of at least 10 pack-years
* Diagnosis of GOLD stage II to IV COPD as documented by pulmonary function testing (FEV1 (Forced expiratory volume in 1 second) \<80 percent predicted, FEV1/FVC(Forced vital capacity)\<0.71)
* Able to walk independently or with a walking aid (e.g. wheeled walker, cane, standard walker)

Exclusion Criteria:

* Unable to walk without assistance of another person
* Patients with a high likelihood of being lost to follow-up or contact (patients with active chemical dependency), are planning to move out of the state, are not living in the healthcare area.
* Patients with an inability to provide good data or follow commands (patients who are disoriented, have a severe neurologic or psychiatric condition).
Acceptance and Commitment Therapy in the Treatment of Obesity: Pilot.

Obesity is an 'epidemic' within the UK. Individuals living with obseity are at risk of developing cancer, heart problems and dieing. Furthermore, obesity impacts on psychological wellbeing via lowered self-efficacy, self-esteem, body image and overall quality of life (QoL). A pilot randomised controlled trial (RCT) is proposed to investigate the additional benefit of a psychological intervention alongside treatment as usual (TAU) in a weight management service. Patients routinely attending an outpatient clinic will be randomised into TAU with or without additional acceptance and commitment Therapy (ACT) group based-input and their outcomes monitored over time.

Overweight and obesity is reported as an 'epidemic' problem within the UK as well as the world. Individuals living with this may be at higher risk of developing co-morbidities, such as cancers, heart problems or diabetes, and higher mortality rates are reported in this group. Furthermore, overweight and obesity can also impact on a person's psychological wellbeing, such as their self-efficacy, self-esteem and body image as well as have a negative effect on their overall quality of life (QoL). Therefore, a pilot randomised controlled trial (RCT) is proposed to investigate the additional benefit of a psychological intervention alongside treatment as usual (TAU) in a weight management service. Patients routinely attending an outpatient clinic will be randomised into TAU with or without additional Acceptance and Commitment Therapy (ACT) group based-input.

Eligibility Criteria:
Inclusion Criteria:

* Individuals will be willing and able to give informed consent for participation in the study;
* Male or Female, aged 18 years or above.
* Individuals will have a Body Mass Index (BMI) of over 40 (or over 35 if they are from a black or other minority ethic (BME) group or have a co-existing physical health problem);
* Individuals will be on a waiting list for a weight loss management programme in the UK;
* Individuals will have English as a written language.

Exclusion Criteria:

* Individuals who are currently pregnant or breastfeeding;
* Individuals with current drug or alcohol abuse, such that would prevent them from engaging in a weight management programme;
* Individuals who are acutely mentally unwell, such that would prevent them from engaging in a weight management programme;
* Individuals who at time of referral are at significant risk to themselves of others, such that would prevent them from engaging in a weight management programme;
* Individuals who are acutely physically unwell and/or hospitalised, such that would prevent them from engaging in a weight management programme;
* Individuals who have a learning disability or cognitive impairment, such that would prevent them from engaging in a weight management programme.
* Currently in receipt of psychiatric services.
The Use of Faster Acting Aspart in Type 1 Diabetes Patients

Data on switching from traditional mealtime insulins to fast-acting insulin aspart (Fiasp) in routine clinical practice are sparse. The aim was to evaluate the efficacy and safety of switching from traditional mealtime insulin to Fiasp in a "real-world" clinical practice setting in people with type 1 diabetes in Belgium.

The primary endpoint was the evolution of time in range (TIR, 70-180 mg/dl) at 6 and 12 months. Secondary endpoints included change in HbA1c, BMI, insulin doses, time below range (T\<70 and T\<54 mg/dl) and time above range (T\>180 and T\>250 mg/dl).

Retrospective analysis Two-center study

Eligibility Criteria:
Inclusion Criteria:

* Type 1 diabetes patients
* Duration of diabetes \> 2 years
* Using CGM for \> 6 months

Exclusion Criteria:

* Using SMBG
* Pregnancy
* Using glucocorticoids or immunosuppressive agents
* Active oncological problem
A Micro-randomized Trial of HeartSteps, an mHealth Intervention for Increasing Physical Activity

The aim of this research is to evaluate the efficacy of contextually tailored activity suggestions and activity planning for increasing physical activity among sedentary adults.

Physical activity is a key behavioral strategy for prevention of non-communicable diseases such as diabetes and heart disease. Mobile health (mHealth) interventions have shown promise for supporting physical activity adoption and maintenance in ways that are highly acceptable to users, scalable, and cost-efficient. This study examines two intervention strategies-contextually tailored activity suggestions and daily planning of the activity for the next day-that a mobile health intervention can use to encourage physical activity in sedentary adults.

Study participants use HeartSteps, an mHealth physical intervention developed by the research team, in their daily lives for six weeks. Over the course of the study both of the HeartSteps intervention components-contextually-tailored activity suggestions and activity planning-are micro-randomized for each participant on each of the day of the study, in order the effects on physical activity of each component separately and how those effects change over time.

The primary hypothesis for suggestions is that providing a contextually tailored activity suggestion increases participant step count over the subsequent 30 minutes following message delivery.

The first secondary hypothesis for suggestions is that the proximal effect of the contextually tailored activity suggestions on the subsequent 30-minute step count will decrease with duration in the study.

The primary hypothesis for planning is that receiving evening planning will increase step count on the following day.

The primary analyses will use the methods developed in Boruvka et al. (2017). The primary longitudinal outcome for activity suggestions will be the log of the step count in the 30 minutes subsequent to decision points. The log of the step count in the 30 minutes prior to randomization will be included as a control variable. The primary longitudinal outcome for planning will be the square root of the step count on the day following the randomization of planning treatment.

All missing but "available" minute-by-minute step counts from the wrist band will be imputed as 0. See "Allocation" section for the definition of availability. Sensitivity analyses using step counts from the mobile phone (secondary data source) will be conducted.

Eligibility Criteria:
Inclusion Criteria:

* English speakers,
* between 18 and 60 years of age,
* could walk for exercise without discomfort, and
* either had a full-time daytime job or a regular schedule outside the home (e.g., students)
* have a personal phone running Android 5.0 or higher or willing to use a study-provided phone as their primary phone for the duration of the study.

Exclusion Criteria:

* Need medical supervision to exercise
* Currently using an activity tracker (e.g., FitBit)
Acute Effects of Endurance Exercise on Breast Milk Composition in Women With Overweight/Obesity

The investigators will determine the acute effect of exercise on breastmilk composition. Participants will come in to the lab on three different days, out of which they will exercise on two of these days and rest in the lab on the third day. The conditions will be randomly allocated to each participant. Breastmilk samples will be obtained in the morning of each test day, as well as immediately after, one hour after and four hours after the exercise/rest condition. Dietary intake will be standardized on the test days.


Eligibility Criteria:
Inclusion Criteria:

* 6 weeks postpartum
* Exclusively breastfeeding
* Term birth
* Singleton baby

Exclusion Criteria:

* Known cardiovascular disease
* Known type 1 or type 2 diabetes
* Limited ability to exercise
Ultrasound Study of the Uterine Healing Process After Cesarean Delivery

Our hypothesis is that there is no difference in the healing process in those women who have a one- or two-layer uterine closure at the time of cesarean delivery.

We are recruiting women who are presenting for their first (primary) cesarean delivery. They will be randomized to one- or two-layer myometrial closure at the time of their cesarean delivery. Ultrasound will be used to serially assess the myometrial thickness and myometrial remodeling process.

Eligibility Criteria:
Inclusion Criteria:

* singleton gestation
* term pregnancy
* Kerr uterine incision employed
* age \> 18

Exclusion Criteria:

* Pain score \> 4
* Current cesarean delivery for non-reassuring fetal status or other emergent situation (eg. maternal bleeding, etc.)
* Prior cesarean section
* Prior uterine surgery
* Hysterotomy other than Kerr (low transverse) incision in current cesarean
* Extension of the uterine incision in current cesarean
* Multifetal pregnancy
* Maternal diabetes mellitus
* Maternal connective tissue disorder
* Uterine malformation
* Uterine myomas (fibroids) in the anterior lower uterine segment
* Chorioamnionitis
* Non-English speaking
MRD Assay Evaluates Recurrence and Response Via a Tumor Informed Assessment

This study recruits patient with solid tumor types for sample collection and monitoring. Participants will provide blood and archival tissue samples in order to create a Personalized Cancer Monitoring (PCM) assay. This assay will be used to detect circulating tumor DNA (ctDNA) levels in the blood over time and hopefully contribute to improvements in residual disease detection methods for future patients.

Results from this assay will be provided to participants and providers but providers are not asked to change patient care based on this information.

This study involves collection of tumor tissue (from a standard biopsy and/or surgery) as well as blood samples over time in order to allow the creation of a Personalized Cancer Monitoring (PCM) assay. Additional blood samples are taken throughout the patient's treatment and follow-up period.

Each participant will submit one blood sample when they begin participation in the research study. Participants will be asked to submit follow up samples several times per year (annually, at minimum), with the exact frequency varying by stage and type of cancer. In general, participants will not be asked to come into the clinic more frequently than their already needed clinic visits.

If the cancer-specific mutations identified by the PCM are detected in the blood samples provided as part of the study, this may would suggests that residual cancer may be present. This is an observational study comparing MRD results to standard of care methods and collecting provider and patient perspectives, using surveys. Physicians will be informed of all PCM results in the form of a clinical report. Physicians are not asked to base treatment decisions on these results.

Eligibility Criteria:
Inclusion Criteria

1. Stated ability to give informed consent by participant.
2. Stated health status of participant as healthy enough to provide Biological Material.
3. Individuals diagnosed with solid cancer of any type, including but not limited to colorectal, non-small cell lung, breast, ovarian and bladder cancers, regardless of the length of time since diagnosis and regardless of previous therapies.
4. Participant is of any biological sex and \>18 years of age
5. Participant has not undergone a blood transfusion within the previous three weeks

Exclusion Criteria

1. Participants who are deemed medically unstable
2. Participants who are deemed to be "difficult to draw" blood from.
3. Participants who are \<18 years of age
4. Participants diagnosed with CNS cancers, sarcomas or hematologic malignancies such as leukemia or lymphoma .
5. Participants with more than one primary cancer
6. Participants with FFPE slides older than 10 years
7. Participants who are pregnant
8. Any other reason that, in the Investigator's judgment, that would preclude the participant from being able to participate in the study
9. Participants for which a pathology report is not available