cyrilzakka/clinical-trials huggingface dataset:
High-dose Dual Therapy with Different Administration Frequencies

This study is a single center, randomized controlled clinical study. The enrolled patients are HP positive. They are diagnosed as HP positive by rapid urease test and/or 13C urea breath test. According to the declaration of Helsinki, 327 patients will be included in this study. After obtaining the written informed consent of the patients, HP culture and drug sensitivity test will be conducted on all the selected patients with the success rate, adverse reactions, compliance, antibiotic resistance of HP and its impact on HP eradication.

According to relevant literature research, amoxicillin TID groups (including before meal group and after meal group) were given Vonorasen (Takeda China) 20mg bid and Amoxicillin 1.0 TID (Zhejiang Jinhua Kangenbei biopharmaceutical Co., Ltd.). Amoxicillin Qid group was given Vonorasen (Takeda China) 20mg bid and Amoxicillin 0.75 Qid (Zhejiang Jinhua Kangenbei biopharmaceutical Co., Ltd.), all the drugs were purchased by the patients from the hospital. The three groups were treated for 14 days respectively, and 13C urea breath test was performed 6 weeks after drug withdrawal. The negative ones were judged as HP eradication.

Eligibility Criteria:
Inclusion Criteria:

* Ability and willingness to participate in the study and to sign and give informed consent
* Confirmed H. pylori infection

Exclusion Criteria:

* Pregnant and lactating women;
* History of gastrointestinal malignancies;
* History of previous subtotal gastrectomy;
* Serious dysfunction of heart, liver, kidney, lung and other important organs and congenital diseases; Such as grade IV cardiac insufficiency, liver failure, uremia, respiratory failure, hemophilia, Wilson disease, etc;
* History of hematological diseases
* People who are allergic to drugs;
* The guardian or patient refused to join the group;
* Alcohol and / or drug abuse (addiction or dependence) or poor compliance judged by doctors;
* No legal capacity or poor self-knowledge
* administration of antibiotics, bismuth, antisecretory drugs, or Chinese herb medicine in the preceding 8 weeks
A Study to Assess the Relative Bioavailability of Oral Tavapadon in Healthy Adult Participants

This study will assess the relative bioavailability of two different Oral formulations of tavapadon in healthy adult participants.


Eligibility Criteria:
Inclusion Criteria:

* Body Mass Index (BMI) ≥ 18.0 to ≤ 32.0 kg/m\^2 after rounding to the tenths decimal at the time of screening. BMI is calculated as weight in kg divided by the square of height measured in meters.
* A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile, and a 12-lead ECG
* Females, Non-Childbearing Potential due to meeting the following criteria:

  * Permanent sterility due to a hysterectomy, bilateral salpingectomy, bilateral oophorectomy.
  * Non-surgical permanent infertility due to Mullerian agenesis, androgen insensitivity, or gonadal dysgenesis; investigator discretion should be applied to determining study entry.
  * Postmenopausal female who is age ≤ 55 years with no menses for 12 or more months without an alternative medical cause AND a follicle-stimulating hormone (FSH) level ≥ 30 IU/L.

Exclusion Criteria:

* History of epilepsy, any clinically significant cardiac, respiratory (except mild asthma as a child), renal, hepatic, gastrointestinal, hematologic or psychiatric disease or disorder, or any uncontrolled medical illness.
* History of suicidal ideation within one year prior to study drug administration as evidenced by answering "yes" to questions 4 or 5 on the suicidal ideation portion of the Columbia-Suicide Severity rating scale (C-SSRS) completed at Screening, or any history of suicide attempts within the last two years.
* Use of tobacco- or nicotine-containing products within 90 days prior to the first dose of study treatment.
The Effect of Intraoperative Magnesium Sulfate Infusion on the Postoperative Recovery

Evaluating analgesic effect of intraoperative magnesium sulfate infusion in the outpatient surgery case


Eligibility Criteria:
Inclusion Criteria:

* aged between 18-65 year-old-patient (ASA I-II) who are planned to undergoing day surgery

Exclusion Criteria:

* ASA class ≥ III
* suspected imbalance of electrolyte
* myocardial damage or conduction delay
* myasthenia gravis or other neuromuscular disease
* impaired renal function
* already using any type of analgesia
* denial of participating in the study or not giving the informed consent
Effect of Zirconia Implant Supported PEKK Crowns Versus Lithium Disilicate Crowns on Esthetics

aim of study is to evaluate esthetic and biomechanical outcome of maxillary anterior single-tooth zirconia implant supported PEKK crowns compared to lithium disilicate crowns on PEKK abutments .

High performance polymers may be a valid alternative to other conventional materials for abutments and crowns over zirconia implants because of their cushioning effect and elastic modulus (5.1GPa), which absorb occlusal forces and avoid overload of the underlying bone from the direct transmission of biting impacts ; which could optimize and preserve osseointegration with time. Zirconia implants with high performance polymers restorations can be considered a good alternative for replacing natural teeth.

For many years lithium disilicate has been the esthetics standard used in Veneers ,Inlays , onlays, occlusal veneers, partial crowns,minimally invasive crowns and Implant superstructures due to its natural-looking tooth colouring and excellent light-optical properties.

Due to the promising esthetics of high performance polymers as it can be veneered with different veneering materials it would successfully restore esthetics.

Eligibility Criteria:
Inclusion Criteria:

* Age \>18 years
* No active intraoral or systemic disease
* No pregnancy or lactation
* controlled periodontal conditions
* Adequate bone volume to place an implant
* Occlusal function with a natural tooth

Exclusion Criteria:

1. Current pregnancy.
2. Psychiatric disorders.
3. Smokers
4. Poor motivation.
5. Several occlusal parafunction.
6. Persistent intraoral infections.
7. Severe mucosal disease.
8. Active periodontitis.
9. Poor oral hygiene.
10. Lack of occluding dentition at implant rehabilitation level
Maintenance of Benefit With Atomoxetine Hydrochloride in Adolescents With ADHD

The purpose of this study is to assess the efficacy, safety and tolerability of atomoxetine administered once daily in the treatment of adolescents with ADHD after 8 weeks and after 52 weeks


Eligibility Criteria:
Inclusion Criteria:

* Patients must have ADHD.
* Must be 13-16 years of age.
* Must be able to swallow capsules.
* Expected to achieve score of 70 or more on IQ test
* Willing and reliable to keep appts. for clinic visits and test

Exclusion Criteria:

* Treatment within last 30 days with a drug that has not received regulatory approval for any indication.
* Patients who weigh less than 40 kg or greater than 70 kg.
* Patients with documented history of Bipolar I or II disorder, or psychosis
* Patients with documented history of autism, asperger's syndrome or pervasive developmental disorder
Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients

Infections on joint replacements remain one of the most serious complications of orthopaedic surgery. Despite improvements in skin preparation and antibiotic prophylaxis procedures, the risk of infection of joint prosthesis is still high, particularly for shoulder prostheses, especially in men. One of the bacteria most often involved in post-operative infections for shoulder prosthesis is Cutibacterium acnes (CA). This bacterium is one of the predominant bacteria in pilosebaceous units. Eradication of this micro-organism remains difficult despite the techniques used in the preoperative phase.

The objective of this protocol is to evaluate the efficacy of applying a 5% benzoyl peroxide topical during the 5 days preceding the procedure in the surgical skin incision area, which is based on local acne treatment, on the reduction of the CA bacterial load in the dermis of the approach to shoulder arthroplasty in men.


Eligibility Criteria:
Inclusion Criteria:

* Male patients, Adult patients,
* Patient without a history of surgical intervention on the operated shoulder,
* Patient managed for glenohumeral, partial (cup or anatomical hemi- arthroplasty) or total (anatomical or inverted) glenohumeral arthroplasty placement for primary osteoarthritis, or secondary to necrosis, massive rotator cuff tear or old fracture.
* Patients affiliated to a social security system
* Patients who have given their informed and written consent

Exclusion Criteria:

* Patient with arthroplasty for resumption of previous shoulder surgery or failure of arthroplasty
* Patient with arthroplasty for acute trauma
* Patient on immunosuppressantsimmunosuppressive drugs
* Patient with inflammatory rheumatism
* Patient with progressive cancer pathology
* Allergies or intolerances concerning the modalities of selected skin preparations (Povidone Iodine, hypersensitivity to benzoyl peroxide)
* Dermatological pathologies in the area to be treated
* Acne treatment in the area to be treated within four weeks before inclusion
* Patient without possible help from a third party for the application of Cutacnyl® 5% in the intervention group if necessary
* Major under guardianship
* Patient under the protection of justice
* Patient not covered by social security
Ketamine Versus Etomidate for Rapid Sequence Intubation

The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).

This study is a randomized controlled trial of etomidate versus ketamine during rapid sequence intubation (RSI). RSI refers to the process by which patients who require emergency airway management undergo sedation and paralysis prior to insertion of an endotracheal tube(airway tube). Patients who require intubation will be randomized to have intubation performed with either ketamine or etomidate. All other care will be at the discretion of the treating physicians. The purpose of this study is to compare the efficacy and safety of ketamine and etomidate during rapid sequence intubation.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age
* Undergoing rapid sequence intubation (RSI) in the Emergency Department

Exclusion Criteria:

* Known contraindication to ketamine or etomidate
* Patient has a condition in which an increase in heart rate or blood pressure would be hazardous, as judged by the treating physician
* Patient is known or suspected of having increased intracranial pressure, based on the history and physical examination performed by the treating physician.
* Females of child-bearing age, defined as 18-50 years, who do not have a documented pregnancy test in this institution confirming that they are not pregnant or who do not have a confirmed surgical procedure preventing pregnancy, i.e., tubal ligation, hysterectomy. The timing of the pregnancy test at which the investigative team will consider a subject to be non-pregnant is a documented negative test during current hospitalization or upon direct transfer from outside institution during current illness.
* Patient declines participation in the trial by wearing a bracelet marked "KvE declined"
* Prisoner
Internet Based Self-help for Problem Gambling Concerned Significant Others

The project aims to evaluate a brief online self-help intervention for Concerned Significant Others of individuals with Problem Gambling. The intervention consists of five modules with texts, films and exercises and is compared to a waiting list.


Eligibility Criteria:
Inclusion Criteria:

* No treatment related to the gambling during the past 3 months for the CSO
* The CSO is at least 18 years old
* The CSO can read and answer questions in Swedish.
* The CSO is assessed as a non-problem gambler according to the Gambling Disorder Identification Test.

Exclusion Criteria:

* Displaying symptoms of severe psychiatric disorders such as psychosis or bipolar disease deemed to needed other treatment options.
Rapid Cadence Cycling for Parkinson's Disease: A Study of Implementation and Efficacy in the Community Setting

Forced cadence cycling (FCC) in which individuals with Parkinson's Disease (PD) pedal with external augmentation at 80-90 revolutions per minute (rpm) has demonstrated significant motor improvement in prior clinical trials. These studies required either a tandem bicycle with second rider or an expensive motorized bicycle, making this therapy inaccessible to most patients. In this pragmatic open-label before and after pilot study investigators examine implementation and effectiveness of (RCC) without tandem or motor augmentation and in a community-based setting. Approximately 30 participants will be recruited to participate in 24 one-hour rapid-cadence spin classes in YMCAs over 8 weeks. Primary outcomes will examine implementation of the intervention and secondary outcomes will examine effectiveness against a historical comparison group.


Eligibility Criteria:
Inclusion Criteria:

1. Adults age 18 or older.
2. Clinically confirmed diagnosis of idiopathic PD by a movement disorder specialist.
3. Hoehn and Yahr stage I-III while ON anti-parkinsonian medication.
4. Stable or absent MAO-B inhibitors (Selegiline, Rasagiline, Zydis selegiline HCL Oral disintegrating) for at least 60 days prior to enrollment; stable or absent other medications for PD motor symptoms (Levodopa, Dopamine agonists, Anticholinergics, Amantadine, COMT-Inhibitors) for at least 30 days prior to enrollment; stable or absent medications for the following PD-non-motor symptoms: depression, anxiety, cognition, sleep, orthostatic hypotension.
5. Agreement to defer any medication changes until after completion of 8-week program and post-test measurements.
6. Written permission by a physician to participate in the program.
7. English language proficiency sufficient to understand and participate in a cycling class taught in English.

Exclusion Criteria:

1. Clinically significant medical disease that would increase the risk of exercise-related complications (eg: cardiac or pulmonary disease, uncontrolled diabetes mellitus, uncontrolled hypertension or stroke) as determined by a treating physician through letter obtained by YMCA or the study investigator.
2. Dementia as evidenced by a score of less than 116 on the Mattis Dementia Rating Scale or dementia in the opinion of the study investigator that would prohibit subject from complying with all study activities.
3. Other medical or musculoskeletal contraindication to exercise.
4. Concurrent participation in another trial of exercise therapy for PD or initiation of a new structured exercise plan during the duration of the study. Note: participants may continue any pre-existing exercise routine (including group-based classes) during the study but will be asked not to start anything new.
Prevalence of Parental Burnout Among Mothers of Children With Cerebral Palsy

This study will be done to determine the prevalence of Parental Burnout among mothers of children with cerebral palsy.

Determine the relation between Parental Burnout syndrome and the motor function levels of children with cerebral palsy.

Cerebral palsy is a significant physical disability in children, affecting 2-5 children per 1,000 live births globally. The prevalence varies between countries and is higher in low- and middle-income countries. Studies suggest a relationship between children's motor impairment and parental stress, which can lead to illness, negative family dynamics, and neglect. Parenting stress and pressure have increased, leading to exhaustion and burnout among parents. This study aims to investigate the prevalence of Parental Bowel Syndrome among mothers of children with CP and its relation to motor function levels.

Eligibility Criteria:
Inclusion Criteria:

* Mothers of children with CP of any age.
* Children diagnosed with CP.
* The age of children will range from 3-18 years old.

Exclusion Criteria:

* Mothers who refuse to participate in the study.
* Mothers of more than one disabled child.
A Study of Bevacizumab (Avastin) in Combination With Dacarbazine in Participants With Unresectable/Metastatic Melanoma

This study will assess the preliminary anti-tumor activity and safety profile of a combination of bevacizumab and dacarbazine in participants with unresectable/metastatic melanoma not previously treated with chemotherapy for metastatic disease.


Eligibility Criteria:
Inclusion Criteria:

* Histologically or cytologically confirmed cutaneous malignant melanoma
* Clinical evidence of metastatic disease and/or unresectable regional lymphatic disease and/or extensive in transit recurrent disease
* Measurable and/or evaluable lesions according to RECIST

Exclusion Criteria:

* Prior interferon alfa and/or cytokine therapy for metastatic disease
* Prior chemotherapy for metastatic disease
* Brain metastases
* Chronic daily treatment with high-dose aspirin (more than 325 milligrams per day)
* Other co-existing malignancies or malignancies diagnosed within the past 5 years with the exception of basal cell cancer or cervical cancer in situ
Patientheque in Patients With a Psychosis .

Establishment of a patient library for patients who have had a first psychotic episode and who have an "at risk" status for psychotic disorder (GRD, APS, BLIPS group) or a psychosis threshold during CAARMS administration. Samples are taken on inclusion, at 2 years, and if relapse or significant clinical event within 5 years of inclusion, on 250 patients for 10 years.

The constitution of this patient library will include results of clinical tests carried out in current practice, neurocognitive tests, blood samples, audio recordings, clinical follow-up, urine samples, fecal samples, brain imaging, EEG.

Eligibility Criteria:
Inclusion Criteria:

* Major and or minor aged 15 to 30 assessed within the CEVUP (Consultation for the Assessment of Psychological Vulnerability) and cared for at the psychiatry center as part of a first psychotic episode (Diagnosis CIM 10: F20 -F29 first hospitalization). These patients are referred by care and medico-social partners (general practitioners, school doctors, school nurses, educators, addictologists, psychiatrists
* "At risk" status for psychotic disorder (GRD, APS, BLIPS group) or psychosis threshold during the CAARMS test (psychometric scale for the assessment of psychotic symptoms)
* Consent of the patient or his legal guardian

Exclusion Criteria:

* History of psychosis for more than one year
* "Not at risk" status for psychotic disorder on the CAARMS (psychometric scale for the assessment of psychotic symptomatology)
* IQ\<70 (WAIS)
* Neurological disorder or other health problem that may explain the disorders
* Refusal to participate - History of psychosis for more than one year
Comparing the Effect of Physical Therapy With Oral Appliance on Temporomandibular Disorder Related Myofascial Pain

the purpose of this study is to compare the effect of physical therapy (PT) program and oral appliance on patients with temporomandibular disorder (TMD)-related myofascial pain (MFP).

The details of each intervention are listed as following:

* physical therapy program group (PT): manual myofascial release over craniomandibular system, chin-in exercise and self-care education
* oral appliance group (splint): custom-made stabilization splint and self-care education

Eligibility Criteria:
Inclusion Criteria:

* (1) 20-65 years old female, (2) diagnosed as MFP subtype of TMD according to Research Diagnostic Criteria for TMD (RDC/TMD), (3) pain duration over 3 month, (4) palpable taut band in masseter, (5) Asymmetrical pain intensity, (6) subsided symptoms of joint inflammation.

Exclusion Criteria:

* (1) traumatic TMD from external impact force, (2) history of traumatic cervical injury, (3) presence of systemic disease, (4) fibromyalgia, (5) co-interventions for cervical problems or TMD during study period, (6) signs of psychosomatic illness, (7) unwilling to be randomized, (8) unable to wear the splint or received intraoral myofascial release, (9)pregnancy.
Signature of the Host Response to a Respiratory Viral Infection, in the Prediction of Bronchiolitis Obliterans

Bronchiolitis obliterans (BO) is the well-known manifestation of the chronic pulmonary graft-versus-host disease(GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The pathophysiology of BO is, however, poorly known. The available data strongly support the role of respiratory viruses, in particular paramyxoviruses (parainfluenzae virus (PIV), respiratory syncytial virus, metapneumovirus). It is likely that the alloimmune response triggered by the respiratory virus is inadequate and leads to the peribronchiolar fibrotic process. The objective is to analyze the kinetics of profiles of the blood and respiratory host responses resulting from a high or low parainfluenza respiratory infection, in order to evaluate if the occurrence of a BO is associated with a specific signature We will evaluate the predictive signature of a BO after a parainfluenza virus infection by characterizing the differences between the patients evolving and those not evolving to a BO at 2 months after the infection.


Eligibility Criteria:
Inclusion Criteria :

* Adults having received a hematopoietic stem cell transplantation for less than two years
* Availability of respiratory function tests prior to infection
* Presence of PIV respiratory infection documented by identification of the virus by PCR in the upper and/or lower respiratory tract
* Symptoms of respiratory infection ≤ 5 days
* Signed informed consent

Exclusion Criteria:

* Presence of a respiratory virus infection other than PIV
* Viral respiratory co-infections
* Bacterial or fungal respiratory infections
* Treatment with ribavirin, oseltamivir or any other antiviral with activity against respiratory viruses
* Patient not affiliated or beneficiary of a social security system
* Patient deprived of liberty or protected
* Pregnant or breastfeeding woman