cyrilzakka/clinical-trials huggingface dataset:
Follow-up the Health Condition , Investigation of the Immuno-regulation , and the Study for Interaction of Viral Hepatitis--- Among Patients With or After Dengue Fever Infection

Originally test host's to understand the tracking healthily and immune change of the dengue fever in Taiwan. Blood drawing 20 c.c for liver examination, kidney and other biochemical function, analyze host immunity adjusts and controls the gene, and the reciprocation that may be produced with the virus hepatitis, besides collected 10 c.c urine at the same time. Urine check is in order to compare acute infect and infected over three month person, the change of chemical composition.

This plan expect to collect 150 healthy, 150 dengue fever infected and 150 dengue fever bleed hot or dengue fever shock disease group's patient, goal to understand health state and immunity of follow-up adjust and control the difference of the gene and the reciprocation may produce to virus hepatitis of light disease and serious disease.

The dengue fever is an important tropical infectious disease in the south of Taiwan, cause and threaten of public health at Kaohsiung and Ping-Dong all over the years, this will cause patient's death, the default of clinical change of dengue fever, acute infect, infect influence, host immunity adjust and control, and the reciprocation of virus hepatitis, will be a very urgent in basic research.

Originally test host's to understand the tracking healthily and immune change of the dengue fever in Taiwan. Blood drawing 20 c.c for liver examination, kidney and other biochemical function, analyze host immunity adjusts and controls the gene, and the reciprocation that may be produced with the virus hepatitis, besides collected 10 c.c urine at the same time.

This plan expect to collect 150 healthy, 150 dengue fever infected and 150 dengue fever bleed hot or dengue fever shock disease group's patient, goal to understand health state and immunity of follow-up adjust and control the difference of the gene and the reciprocation may produce to virus hepatitis of light disease and serious disease.

Urine check is in order to compare acute infect and infected over three month person, the change of chemical composition. The result of study can help doctor to understand the factor of immune regulation and control of the host and health change after the dengue fever is infected with, possible reciprocation with virus hepatitis. Researchers have collect 100 dengue fever bleed hot or dengue fever shock syndrome groups of patient, it is estimated that can collect and expect the case will be counted within two years.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of Dengue Fever
Whitsundays (Nasal) Mask Take Home Study (90 Days)

The goal of this multi-site, prospective, randomized, double arm study without blinding is to test the usability of the Whitsundays mask system at home by patients with Obstructive Sleep Apnea. The main questions it aims to answer are:

* How the Whitsundays masks performs in the home environment
* What is the subject's first impression of the Whitsundays mask and what is their preference compared to their own mask
* What is the difference between the subject's objective therapy data when using the Whitsundays mask compared to their own mask
* Is there wear and tear of the Whitsundays mask and how frequently do the cushions need replacement Participants will be asked to use the Whitsundays mask for 90 days, answer questionnaires about the initial impression of the mask, the performance of the mask, and their preference compared to their own mask. Researchers will compare one group of subjects who will be provided with cushion replacements to another group who will only be provided with cushion replacements upon request to determine the need for cushion replacement, its frequency, and the reasons for cushion replacement during home usage.


Eligibility Criteria:
Inclusion Criteria:

* Patients willing to give written informed consent
* Patients who can read and comprehend English
* Patients who ≥ 18 years of age
* Patients being treated for OSA with a PAP device for ≥ 6 months
* Patients currently using a ResMed PAP device (S9, AirSense 10 \& AirSense 11) compatible with AirView (with cellular data connectivity and has been sending device data to the cloud)
* Patients currently using ResMed AirFit N30i or Philips DreamWear™ Nasal
* Patients who are willing to try the prototype mask for up to 90 nights
* Patients who are willing to take photos of the prototype mask every 2 weeks for the duration of the study
* Patients who reside in the USA and intend to stay in the USA for the next 6 months
* Patients with access to the internet (such as a smartphone or laptop) to complete online surveys

Exclusion Criteria:

* Patients using Bilevel flow generators
* Patients who are or may be pregnant
* Patients with a preexisting lung disease/condition that would predispose them to pneumothorax (for example: COPD, lung cancer; fibrosis of the lungs; recent (\< 2years) case of pneumonia or lung infection; lung injury.
* If you are pregnant or planning to become pregnant
* Patients believed to be unsuitable for inclusion by the researcher
Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.


Eligibility Criteria:
Inclusion Criteria:

For the exercise studies of leg glucose uptake - "insulin sensitive" group:

* Sedentary, normal weight, premenopausal women.
* Sedentary, age-matched normal weight men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.
* For the exercise studies of leg glucose uptake - "insulin resistant" group:

For the exercise studies of leg glucose uptake - "insulin resistant" group:

* Upper body obese (UBO) premenopausal women.
* Age-matched upper body obese (UBO) men.
* Weight stable for two (2) months prior to study.
* Willing to provide written, informed consent.

Exclusion Criteria:

* Age \< 18 or \> 55 years (premenopausal women and age-matched men).
* Use of glucose-lowering agents.
* For female subjects: positive pregnancy test at the time of enrollment or study
* History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
* Active systemic illness or malignancy.
* Symptomatic macrovascular or microvascular disease.
Association Between Antidepressant Use and Falls in Older Adults: Analysis of the World Health Organization Global Database

The incidence of fall in older adults aged 65 and over is estimated at 30%, and 50% of the people aged 80 and over with at least one fall a year. Falls are associated with significant morbidity and mortality.

The origin falls is often multifactorial, involving intrinsic and extrinsic factors. Few studies have investigated the association with all antidepressants. Potential adverse effects of antidepressants such as hyponatremia, sedation, orthostatic hypotension, extrapyramidal symptoms are known risk factors for falls. Due to multimorbidity, polypharmacy including interaction risks, and aging-related changes in pharmacokinetic and pharmacodynamic of drugs, antidepressants may further increase this risk in older patients.

Based on the World Health Organization global database, the main objective of this study is to investigate the association between antidepressants classes and the occurrence of falls reported in the database.

A disproportionality analysis will be performed. It will aim to assess whether some classes of antidepressants, and within these classes some molecules, are associated with a greater risk of falls.

A mediation analysis will also be performed. It will aim to examine some of the mediators involved in the association between antidepressants classes and falls.


Eligibility Criteria:
Inclusion Criteria:

* be over 65 years old
* take antidepressants
* have already presented falls

Exclusion Criteria:

-
Validation of the Turkish Version of the Modified Early Obstetric Warning Systems (MEOWS) Charts

It was aimed to study MEOWS on patients in the obstetrics clinic and to evaluate the performance of this scale as a screening tool and to contribute to its usability in Turkey by translating MEOWS into Turkish.

The Modified Early Obstetric Warning System (MEOWS) is a score-based or color-coded system used to detect changes in physiological parameters and enable earlier recognition and management of deteriorating patients.It was first validated by Sigh et al., then its validity and reliability were demonstrated in many countries, especially in countries with low socio-economic status.Early warning systems are not routinely used in obstetrics clinics in Turkey, and there is no Turkish version of MEOWS in the literature. In this study, it was aimed to study MEOWS on patients in obstetrics clinics and to evaluate the performance of this scale as a screening tool and to validate MEOWS by translating it into Turkish.

The study was carried out in 3 stages. The first stage is the translation of MEOWS into Turkish and its cultural adaptation, the second stage is the use of the study scale and the elimination of deficiencies by conducting a pilot study on 30 patients, and the third stage is the collection and evaluation of patient data until the specified sample size is reached.

Eligibility Criteria:
Inclusion Criteria:

* Obstetric patients receiving inpatient treatment in obstetrics and gynecology clinics
* Patients whose pregnancy is older than 28 weeks and between 6 weeks postpartum
* Patients who agreed to participate in the study

Exclusion Criteria:

* Patients who did not agree to participate in the study
* Patients under the age of 18
* Outpatients
Environmental Factors and Thyroid Cancer

Thyroid cancer incidence has been steadily increasing and has nearly tripled since the 1970's in the US and worldwide. Early detection of small, papillary thyroid cancers using high quality diagnostic imaging explains only about 50% of this increased incidence, suggesting that there is a true increase in the occurrence of thyroid cancer and that changes in the prevalence of environmental risk factors might play a role in thyroid cancer etiology and progression. Yet, the cascade of environmental triggers linked to thyroid cancer remains elusive.

'Exposomics' studies all health relevant chemical exposures that an individual experiences, and leverages metabolomic platforms to estimate the "internal" environment, informing both exogenous exposures and the metabolic products that lead to, or arise from, disease. Besides exposure to ionizing radiation as known modifiable risk factor, epidemiological evidence suggests that exposure to endocrine disrupting chemicals may be a potential thyroid cancer risk factor due to their known effects on thyroid function. However, these studies relied either on exposure questionnaires which are susceptible to recall bias, or used a limited set of targeted biomarkers measured after diagnosis for testing associations with case-control status, and not thyroid cancer prognosis. Further, the molecular basis for observed associations with thyroid cancer remains unclear.

To address the overall hypothesis that environmental exposures alter metabolic pathways and therefore affect thyroid cancer prognosis, small amounts of blood will be collected using dried blood microsampler technology (e.g. Mitra® sampling devices), which is minimally invasive and can be used to collect repeated blood measurements at home, without the need for specialized training. These dried blood samples will be used to perform metabolomics experiments, which describe the sum of exogenous exposures, metabolic alterations, and biological response. Additional exposure assessment will be performed using an exposure questionnaire. These results will be associated with thyroid cancer prognosis, e.g. disease-specific survival, disease recurrence, and mutational profiles, thus investigating the role of environmental exposures in the development of more aggressive forms of thyroid cancer.


Eligibility Criteria:
Inclusion criteria:

* Bethesda category III, IV, V or VI following Fine Needle Aspiration; if a patient has a benign tumor following surgery, patient data/ samples will be stored to serve as benign control in potential future projects.
* Age 18 years and older
* Surgical candidate
* Ability to provide informed consent

Exclusion criteria:

* History of thyroid cancer
* Completion surgery candidate
* Pregnant women or other vulnerable patients (e.g. wards of the state, prisoners)
Ingestion of Beta-alanine Effects in Well-trained Tennis Players

Beta-alanine is considered as ergogenic aids with good to strong evidence for improving sports performance in specific sports context scenarios. However, most of the studies has been realized in endurance, with limited evidence in intermittent sports, especially in racket sports. Thus, the aim of this study was to explore the effects of 4-weeks ingestion of beta-alanine on neuromuscular performance in well-trained tennis players.

Fourteen tennis players (23.3 ±3.7 years) between 50-250 national tennis ranking participated in this study. Participants were randomly divided into two groups that realized a neuromuscular battery after beta-alanine (4.8 gr/daily during 4-weeks) or placebo (i.e., fructose) (4.8 grams/daily during 4-weeks). Before and after the supplementation period tennis performed a neuromuscular test battery in a tennis court consisted in different test such as; serve velocity, countermovement jump, isometric handgrip strength, 10-m sprint, modified 5-0-5 agility test and repeated sprint ability. After 48 h of the realization of neuromuscular test battery, tennis players performed VO2max consumption test (i.e., treadmill).

Eligibility Criteria:
Inclusion Criteria:

* Well-trained tennis players, between 18-35 years old (50-200 between tennis ranking)

Exclusion Criteria:

* Suffering from any chronic pathology or an injury in the month prior to the investigation.
* Intolerance to beta-alanine ingestion
* Amateur tennis players.
Mental Practice in Parkinson's Disease

Introduction Although drug therapy is the mainstay of treatment for Parkinson's disease, the therapy also has its importance by means of exercises which maintains the muscular activity and preserve mobility. One of the techniques that has been used for physical therapy is the mental practice of the mental simulation of movement, aiming at learning or improvement of motor skills through the cortex areas of activation responsible for the movement of preparation before it is executed. In patients with Parkinson's disease motor anticipation this system is compromised, culminating in the march changes and increased risk of falls. Objective: To evaluate the effects of mental practice on physical therapy on the march and the risk of falls in people with Parkinson's disease. Method: The study is defined as a randomized clinical trial with systematic recruitment. Recruitment will be conducted at the Clinic of Neurology, Hospital das clinics Federal University of Pernambuco (Pro-Parkinson Project: Neurology) and the intervention will be held at the same hospital physiotherapy clinic. Both the control group and the trial will be subjected to 15 therapy sessions twice a week, lasting 40 minutes for physical therapy and 15 for mental practice.


Eligibility Criteria:
Inclusion Criteria:

* Patients with clinical diagnosis of idiopathic Parkinson's disease
* Male and female
* Stage 1-3 of the Hoehn and Yahr scale.

Exclusion Criteria:

* Have other neurological diseases
* They have decompensated systemic diseases
* Musculoskeletal changes that prevent the achievement of movements
* With lowering of the cognitive level assessed using the Mini-Mental State Examination with cutoff point according to education
* With respiratory impairment
* With medical restrictions for performing exercises
* Do not get hold motor imagination during the application of Visual and Kinesthetic Imagery Questionnaire-10
* In physical therapy, occupational therapy service for 3 months or more;
* Patients with moderate to severe depression assessed by inventory Beck Depression Inventory
3D-printed Reconstruction Automated Matching System Predicts Size of Double-lumen Tube: a Prospective Double-blinded Randomized Controlled Trial

Lung isolation techniques are commonly used to facilitate surgical exposure and to provide single-lung ventilation for patients. We have developed an automatic comparison software for 3D reconstruction based on CT data (3DRACS). It reconstructs the trachea and bronchus and compares them with the DLT, predicting the most suitable size and depth of the DLT for lung isolation.The aim of this study was to compare whether the use of 3DRACS to select a DLT size compared to conventional empirical selection methods could improve incidence of DLT intubation success and reduce airway injury.

Lung isolation techniques are commonly used to facilitate surgical exposure and to provide single-lung ventilation for patients undergoing various intra-thoracic procedures. Lung isolation is primarily accomplished with a double-lumen tube (DLT) or bronchial blocker. One published study showed that residents with limited experience had a 40% error rate in accurately placing a DLT. The accurate choice of the size of DLT is a prerequisite for good lung isolation.Currently, There is lack of proper objective criteria for selecting size of DLT. DLT size selection is estimated empirically using the patient's height and sex, and studies have shown that the size of DLT according CT images of the chest is more accurate than experience. we have developed an automatic comparison software for 3D reconstruction based on CT data (3DRACS). It reconstructs the trachea and bronchus and compares them with the DLT, predicting the most suitable size and depth of the DLT for lung isolation. The aim of this study was to compare whether the use of 3DRACS to select a DLT size compared to conventional empirical selection methods could improve incidence of DLT intubation success and reduce airway injury.

Eligibility Criteria:
Inclusion Criteria:

1. Aged between 18 and 75 years.
2. American Society of Anesthesiologists Physical Status (ASA-PS) I-III.
3. Planned to receive lung resection surgery during lung isolation techniques by using DLT.
4. Signed informed written consent.

Exclusion Criteria:

The participant experiences any of the following：

1. Spinal malformation,
2. Expected difficult airway
3. Tracheal stenosis
4. Tracheal tumor
5. Bronchial tumor
6. Distorted airway anatomy
7. Tumors of the mouth or neck
SurgiMend Mesh at the Hiatus

Prospective, single-arm, open-label study to evaluate re-occurrence and quality of life in subjects undergoing primary Hiatal hernia repair using SurgiMend biological mesh. Up to 15, with a target of 10, subjects are planned to be enrolled at one site. All subjects will receive the SurgiMend mesh during surgery. Data collected will be compared to historical data.

Subjects will complete a pre-operative visit. After surgery, in addition to any standard of care visits, subjects will complete 3- and 6-month follow-ups involving a phone QOL survey and will have an upper GI series at 6 months.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of type 3 or 4 hiatal hernia (8)
* Subject is able to give informed consent
* Adults at least 18 years of age

Exclusion Criteria:

* Currently pregnant
* Prior hiatal hernia repair
* Prior gastric surgery
* Prior foregut surgery
* Known esophageal dysfunction or dysmotility
* Cirrhosis or ascites
* Known malignancy
* Known allergy to biologic mesh
* Known allergy to barium or other contrast material used in UGI
* Religious objection to animal implant
* Cognitive impairment
* Prisoners
24-hour Blood Pressure Dynamics and Autonomic Adrenergic Regulation in Type 2 Diabetics

Autonomic neuropathy is a common complication of type 2 diabetes mellitus. Symptoms from cardiovascular autonomic neuropathy include, dizziness, orthostatic hypotension and insufficient heart rate and blood pressure (BP) regulation during physical exertion. The degree of cardiovascular autonomic neuropathy is most commonly measured as cardiac autonomic neuropathy based on at least two abnormal cardiac reflex tests, which primarily measures parasympathetic indices of the autonomic nervous system (ANS).

Few measures are available for quantifying the sympathetic/adrenergic branch of the ANS.

Circadian changes in BP is a documented measure of BP variability, regulated centrally by a multitude of centers. A growing number of studies indicate that a diminished BP variability is associated with increased cardiovascular risk and injury. The ANS plays a pivotal role in the execution of these circadian BP changes, mainly through sympathetic adrenergic nerve fibers

Few studies have investigated the applicability of 24-hour indices as predictor for autonomic adrenergic dysfunction. No previous studies have investigated the association between clinical markers of adrenergic function, and 24-hour blood pressure indices in type 2 diabetes.


Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetes
* Normal 12-lead ECG

Exclusion Criteria:

* Significant cardiovascular, muscular, lung, kidney or psychiatric disease
* Pregnancy
* Malignant disease, HIV, alcoholism or drug abuse
* Parkinson disease
* Ischemic heart disease
* Vital medicine that can affect the autonomic nervous system
Role of MDSCs and Cancer Stem Cells and Their Cross Talks in NSCLC

Immunotherapy have revolutionized the field of oncology, but response rates are low and all patients relapse, due to cellular and soluble immunosuppressive mechanisms. MDSC are one of the most important immunosuppressive cells, that also harbour non immunologic functions, favouring cancer invasion. These non immunologic functions of MDSC in lung cancer will be better characterized. Indeed, cellular mechanisms will be analysed by in vitro studies, assessing the effect of immunosuppressive cells, provided by fresh tumor samples, on phenotype and functions of lung cancer cell lines. The aim of this study is to better characterize immunosuppressive landscape of NSCLC and mechanisms involved in their protumor functions.

In recent years, immune-based therapies have revolutionized the field of oncology by significantly improving survival of cancer patients. Despite sustained responses, only 20% to 40% of cancer patients respond. It has become clear that the immunosuppressive environment induced by tumor through cellular and/or soluble pathways critically contribute to hinder efficient antitumor immunity. The inhibition of these immunosuppressive networks thus represents an essential prerequisite for the improvement of responses to anticancer immunotherapies. Several immune cell populations have been identified as key actors of tumor-induced immunosuppression, among which are myeloid-derived suppressor cells (MDSC) and regulatory T lymphocytes (Treg). However, in non-small cell lung cancers (NSCLC), the prognostic role of these cells, the mechanisms underlying their immunosuppressive functions, their "non-immunological" protumoral functions and their role in dampening the efficacy of immunotherapies in clinical practice are less characterized. The aim of this project is to better characterize the non immunologic functions of MDSC. We propose to assess in vitro the non-immunological pro-tumor functions of MDSC isolated from lung cancer patients

Eligibility Criteria:
Inclusion Criteria:

* consecutive patients
* lung carcinoma surgically treated by surgery only

Exclusion Criteria:

* patient receiving chemotherapy, radiotherapy or immunotherapy in the neoadjuvant setting (all objectives)
* patient with concomitant or previous cancer (in the 2 years)