cyrilzakka/clinical-trials huggingface dataset:
Dexmedetomidine Combined With Hydromorphone in Tonsillectomy and Adenoidectomy

Tonsillectomy and adenoidectomy is one of the most common pediatric surgeries, and agitation and severe postoperative pain have been considered a very common complications. Dexmedetomidine mainly inhibits the release of norepinephrine by acting on the α-adrenergic receptor of the brainstem nucleus, which can produce good sedative effects. Hydromorphone has a longer duration of action than fentanyl, and it also has a certain sedative effect. The combination of the two is more conducive to the management of postanesthetic agitation and pain. This study was to compare the effect of different doses of dexmedetomidine combined with hydromorphone in the sedation and analgesia after pediatric tonsillectomy and adenoidectomy.

The computer generates random numbers to allocate patients into different group. Trained research staff who are not involved in the study collect the data. The observer who only stayed in PACU was blinded to the allocation and responsible to record the data.

The primary measurement are pain scores, PAED scores, coughing was evaluated on a 9-point scale (1= no coughing, 2= minimal coughing, one or two times, 3-4= moderate coughing, 3-4 times, 5-6= moderate coughing, more than 5 times, 7-8= severe coughing, more than 10 times, 9= laryngospasm), and extubation time. The secondary measurements are the time to discharge from the post-anaesthesia care unit, and the number of postoperative desaturation.

A sample size of 57 was determined by analysis based on the assumption of the decline of extubation time from other similar study and α=0.05,β=0.2.

The continuous variables were presented as means ± SD and the categorical variables were expressed as frequency.

The outcome of interest is extubation time decline.

Eligibility Criteria:
Inclusion Criteria:

* experienced tonsillectomy and adenoidectomy
* ASA physical status I-II
* weight 12-30 kg

Exclusion Criteria:

* respiratory disease
* circulatory or nervous system disease
* hepatic dysfunction
* known adverse reactions to hydromophine and dexmedetomidine
Evaluation of Some Trace Elements in Follicular Fluid in ICSI Cases and Their Effect on ICSI Outcomes

To evaluate concentrations of some trace elements in the follicular fluid and their reproductive outcomes.

To evaluate some trace elements in the follicular fluid and their reproductive outcome

Eligibility Criteria:
Inclusion Criteria:good responders according to NICE guidelines with AMH more than 0.8ng/dl and antral follicular count more than 4 Exclusion Criteria:Poor responders according to ESHRE guidelines as advanced maternal age poor ovarian response and according to NICE guidelines AMH less than 0.8ng/dl
Investigation of the Effect of Kinesiotape Applied With Exercise on Muscle Oxygenation With Moxy Muscle Oxygen Monitor

Kinesio taping (KT) is an elastic adhesive tape with physiological effects, often used in rehabilitation and sports medicine. KT, which can stay in the body for 3 to 5 days, exerts a pulling force on the skin thanks to its wave-like structure and elasticity, and increases the gap between the subcutaneous soft tissue and fascia with its lifting effect. In this way, it reduces the superficial pressure and causes an increase in lymph circulation. In addition, with the effect it creates on the muscles, it allows maximum contraction and relaxation of the muscle and creates positive effects on the deep lymphatics. Another effective approach to increase blood circulation is exercise. Exercise, which is known to have many benefits, has been shown to increase both systemic circulation and muscle blood flow. There are findings in the literature that KT can increase the effectiveness of exercise, but it has been stated that this issue is not clear and more studies are needed. In order to evaluate the effects of KT on increasing the effectiveness of exercise and on circulation, the oxygen saturation of the muscle in the application area can be measured. As a matter of fact, "Moxy muscle oxygen monitor" has been used in the literature, which measures regional oxygen saturation (SmO2) and total hemoglobin (THb) in capillaries under the muscle. The Moxy muscle oxygen monitor is a lightweight (42 g) and small (dimensions: 61 × 44 × 21 mm) device that measures regional blood flow and oxygenation by placing it on the skin non-invasively with near-infrared spectroscopy (NIRS). Its validity in measuring muscle oxygenation was vigorous or fairly good, and its reliability was found to be moderate to high in low-intensity exercises (SROC: r = 0.842-0.993, ICC: r = 0.773-0.992, p \< .01). It is thought that the application of KT, which is known to increase lymphatic and venous circulation, together with exercise will increase the amount of oxygen in the muscles. To the best of our knowledge in the literature, no study has been found in which this effect of KT is presented objectively. For this reason, it is aimed to examine muscle oxygenation with the Moxy muscle oxygen monitor, which provides objective data on KT applied with exercise.


Eligibility Criteria:
Inclusion Criteria:

* Volunteering to participate in the study
* Being between the ages of 18-40
* Being sedentary (\<600 MET-min/week according to the International Physical Activity Questionnaire Short Form)
* BMI \<30kg/cm2
* Subcutaneous fat thickness \<12mm

Exclusion Criteria:

* Having an open wound or infection in the application area
* Having a chronic illness
* Being pregnant
* Having a psychological disorder
* Having a lower extremity injury in the last 6 months
* Having had any surgical operation involving the lower extremity in the last 6 months
A Pilot Study on Usefulness of Probe-based Confocal Laser Endomicroscopy Targeted Gastric Biopsy

The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer cells in biopsy samples is usually 30% or less. Recently, confocal laser endomicroscopy has been introduced for real-time histopathologic diagnosis in various cancers. The investigators aim to evaluate that biopsy using probe-based confocal laser endomicroscopy will increase the percentage of cancer cells in biopsy samples.


Eligibility Criteria:
Inclusion Criteria:

1. Age, between 20 and 80
2. Initial-onset gastric cancer which would be treated with surgery

Exclusion Criteria:

1. Previous subtotal gastrectomy
2. Pregnancy or breast milk feeding
3. Active infection
4. Significant cardiopulmonary disease
5. Active hepatitis or severe hepatic dysfunction
6. Severe renal dysfunction
7. Severe bone marrow dysfunction
8. Severe neurologic or psychotic disorder
E-Nose: Diagnostic Tool for Pleural TB

The purpose of this study is to determine the diagnostic utility of the device 'Electronic Nose' for Pleural TB, which is a Extra pulmonary TB form, compared with pleural biopsy, the current gold standard.

The aim of the study is to determine the diagnostic utility of the device 'Electronic Nose' for Pleural TB, which is a Extra pulmonary TB form.

The patient who qualified for the study, according to the inclusion criteria, after consenting, will be guided through and oriented survey for risk factors, then a complete physical exam, and after that, the patient will breathe for 5 minutes trough the device, which stores the patient information, that later will be download to a computer and will be send to the server's manufacturer company, in Netherlands.

During and after the use of the device, investigators determine the adverse effects of the intervention, according to the CTCEA.

Investigators use the pleural biopsy, which is the gold standard, to determine the diagnostic utility of the test. And, will compare the results with other tests currently perform as the regular diagnostic routine, such as Chest CT, adenosine deaminase value of pleural fluid and cytomorphologic \& cytochemistry of the pleural fluid.

Patient Registries will be keep in an electronic database, as well as handwriting history, with the backup copy in the records of the hospital in which the patient was admitted.

Auditories will be realised by the Ethics Committee in different time frames.

Eligibility Criteria:
Inclusion Criteria

1. Accept to participate in the study through a signed informed consent approved by the Ethical Committee of our Institution.
2. More than 15 years old.
3. Pleural effusion of any etiology

Exclusion Criteria:

1. Severe compromise of the general condition
2. Not capable to exhaled through the E-nose.
3. No possibility to follow-up.
4. By discretion of the research team.
Repeated Versus Varied Simulation Scenarios to Teach Medical Students the Management of a Pediatric Asthma Exacerbation

Repeated exposure to simulated cases has been shown to improve performance, but repeating the same scenario may impair the ability of learners to transfer their knowledge and skills to slightly different situations. The objective of this study is to compare the use of repeated versus varied simulation cases for teaching the management of pediatric asthma exacerbation to 3rd year medical students.


Eligibility Criteria:
Inclusion Criteria:

* Third year medical students from Paris Descartes and Paris Diderot medical faculties.
* Who are not opposed to participated in the study

Exclusion Criteria:

* Opposition to participate in the study
Ameliorating Contrast Induced Nephropathy After Coronary Angiography

Given the limited understanding of the impact of statin and N-acetyl cysteine use before angiography in preventing contrast-induced nephropathy (CIN), the objective of this study is to evaluate the effectiveness of atorvastatin in preventing CIN among patients undergoing coronary angiography.

A multi armed randomized controlled clinical trial to be conducted from June 2023.According to inclusion and exclusion criteria, All patients presenting to the Cardiology department at Ain Shams University hospitals, will be assessed for eligibility. At least 120 patients subjected to elective CT coronary angiography who are at risk of developing contrast-induced renal failure will be enrolled. The participants will be assigned to Three groups (40 patients for each group):

* Three groups
* High-dose Atorvastatin group: 40 patients will receive 80 mg Atorvastatin before coronary angiography and will receive adequate hydration using (1ml/kg/hr)
* N-acetyl cysteine group: 40 patients will receive 200mg 3 times daily 2 days before coronary angiography and 2 days after and will receive adequate hydration using (1ml/kg/hr)
* Control group: 40 patients will receive adequate hydration using (1ml/kg/hr) The blood sample will be collected from all patients before the administration of contrast media and after 24 hours for assessment of the needed parameters.

Eligibility Criteria:
Inclusion Criteria:

* Undergoing elective Coronary angiography who will receive coronary angiography contrast media.
* Must have at least two consecutive serum creatinine measurements (Before and after Contrast exposure)

Exclusion Criteria:

* Pregnant or lactating women
* Patients with Serum creatinine conc of \>2.1 mg/Dl
* Patients undergoing emergency primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.
* Prior exposure to contrast media within 7 days
* Contraindication for a high-dose statin, N-acetyl Cysteine prescription
Aerobic Training With and Without Resistance Training in Polycystic Ovarian Syndrome

Polycystic ovary syndrome (PCOS) characterized by a chronic disorder in ovulation along with hyperandrogenism has become one of the most common endocrine disorders in women of reproductive age with an estimated 5%-15% prevalence. It has the symptoms such as menstrual disorders, infertility, hyperandrogenism, obesity, hirsutism and acne. PCOS is linked to Psychological morbidities e.g. increased risk of stress, depression, low self-esteem, poor body image, and reduced health-related quality of life. Approximately 75% of people with PCOS have a fat accumulation in the central area of the body.

A Randomized controlled trial will be conducted to determine the effects of Aerobic training with and without resistance training on the waist to hip ratio, QoL and menstrual dysfunction in polycystic ovarian syndrome. A sample size of 22 PCOS women's will be taken, Data will be collected from Jinnah Hospital Lahore by using PCOSQ and SF-36 questionnaire. A written consent form will be taken from participants meeting inclusion criteria and will be randomly allocated into two groups of equal members. One group undergoing aerobic with resistance exercise training i.e., the experimental group and other with aerobic exercise i.e., control group. The interventions will be provided for 30 mints for 3 days per week for 2 months. All participants in both groups will be evaluated before and after the treatment programs.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-40yrs
* Waist to hip ratio \>87(20)
* Women who are diagnosed according to Rotterdam criteria e.g. oligo/anovulation, hyperandrogenism, and polycystic ovaries.(21)
* Female who physically able to performs exercise

Exclusion Criteria:

* Women who are smoking and using drugs for depression.
* Married women
* Women with other pathological conditions like diabetes and thyroid diseases.
* Females who are not able to perform resistant exercise
Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depression Episode

The purpose of this study is to evaluate flexible doses (5-30mg) of aripiprazole versus placebo in patients with bipolar depression.


Eligibility Criteria:
* ages 18-65
* Men and women, who have experienced a prior manic episode that required hospitalization, and now meet criteria for a major depressive episode.
Chama Cha MamaToto: a Pilot Study of Peer Support Groups in Kenya

Preventing maternal and newborn deaths remain high on the global agenda. To address this, the Academic Model Providing Access to Healthcare (AMPATH), in partnership with the Government of Kenya, launched Chama cha MamaToto, a community-led peer-support model that groups women together in pregnancy and infancy. Central to the chama approach is the integration of health, social and financial literacy education with a savings/loans program.

To evaluate the feasibility of chamas, we analysed group attendance rates, GISE participation, membership retention, and continuation of the groups beyond the one year. To evaluate the effect of chamas, the investigators compared data from a prospective cohort of women in chamas with a group of controls who did not belong to a chama, matched for age, parity, and location of prenatal care. To evaluate the acceptability of chamas, FGDs were carried out with chama and non-chama participants, health providers and community health workers.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women in communities where chamas were taking place
* Any woman attending chama

Exclusion Criteria:

-
Impact of A Multidimensional Health Education Program on Attention Deficit Hyperactivity Disorder (ADHD)

To measure the impact of a multidimensional health education program on patients' adherence to the healthy life style and behavioral therapy , and to correlate it with severity of ADHD symptoms

Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder whose etiology is the result of complex interactions between multiple factors, including genetic, biological, and environmental influences. Attention deficit hyperactivity disorder (ADHD) is a condition that affects people's behavior. People with ADHD can seem restless, may have trouble concentrating, and may act on impulse. Symptoms of ADHD tend to be noticed at an early age and may become more noticeable when a child's circumstances change, such as when they start school. Most cases are diagnosed when children are 3 to 7 years old, but sometimes it's diagnosed later in childhood .

A mean worldwide prevalence of attention-deficit hyperactivity disorder (ADHD), or hyperkinetic disorder (HKD), of \~2.2% overall (range, 0.1-8.1%) has been estimated in children and adolescents (aged \<18 years) . Regarding the prevalence of ADHD in Arabic countries, results from previous studies showed that it reached 9.4-21.8% in Egypt ,and 11.6% in Saudi Arabia .

Several harmful consequences are associated with ADHD, including deficient academic/work performance, social isolation, aggressive behavior (including delinquency and illegal acts), and even premature death from unnatural causes (such as accidents) Undesirable lifestyle factors could contribute directly to inattention and/or hyperactivity symptoms, numerous mechanisms exist that could mediate such effects, such as secondary effects on energy level, immune function, and epigenetic change.

Study findings showed that children with ADHD were approximately two times as likely to have a healthy lifestyle index that is lower than children without ADHD Multiple studies on alternative interventions for ADHD aim at the prevention of ADHD progression and targeting the underlying triggers (such as stress, poor sleep, overstimulation, technology or dietary plans). On the basis that making adequate lifestyle changes to minimize these triggers could contribute to better control of ADHD symptoms .

Eligibility Criteria:
Inclusion Criteria:

* Patients newly diagnosed with mild and moderate ADHD not receiving medications or behavioral therapy, aged 6-9 years, and parents are motivated to participate in the lifestyle modification program.

Exclusion Criteria:

* Children with severe form of ADHD or with comorbid psychiatric disorders rather than disruptive behavior disorders, and children with an intelligence quotient score below 80 were excluded.
Controlled Randomized Stimulation Versus Resection (CoRaStiR)

Patients will be prospectively randomized to 3 different treatment arms:

* Treatment group 1: patients who undergo medial temporal lobe resection
* Treatment group 2: patients who receive immediate hippocampal neurostimulation
* Treatment group 3: patients who are implanted with an intracranial electrode but in whom hippocampal neurostimulation is delayed for 6 months.

Twelve months after inclusion unblinding will occur. Patients in group 2 and 3 will have the option to choose between continuing neurostimulation treatment or resective surgery.

Study visits will occur every 3 months.


Eligibility Criteria:
Inclusion Criteria:

* Presurgical candidates with pharmacoresistant partial seizures despite optimal medical treatment and history of temporal lobe epilepsy
* Age above 18 years
* TIQ \> 80
* Able to give informed consent
* Average of 2 partial seizures per month during a baseline of 3 months. Recording of seizures must have been done in a prospective manner using standard seizure diaries.
* Able to adequately report seizure frequencies using standard seizure diaries
* Video-EEG characteristics showing temporal lobe seizure onset (left-sided or right-sided seizure onset) in at least one recorded habitual seizure
* Presence of a structural abnormality in the medial temporal lobe, suggestive of hippocampal sclerosis as evidenced by optimum MRI
* Women of child-bearing age will be required to use a reliable method of contraception during the study duration

Exclusion Criteria:

* Extratemporal epilepsy; multifocal epilepsy; evidence of bilateral medial temporal lobe epilepsy
* MR evidence of potentially epileptogenic lesions outside the medial temporal lobe such as dysplasias, tumours or cavernomas
* Prior resective intracranial surgery
* Patients who are candidates for invasive video-EEG recording or have previously been investigated with invasive video-EEG recording
* Patients who previously underwent any other type of neurostimulation for treating epilepsy
* Patients who are unable to fill in questionnaires and comply with protocol requirements
* Progressive neurological or medical conditions
* Medical or psychiatric conditions precluding surgery or compliance
* Patients taking antidepressant medication
* Pregnancy at study onset
* Previous (within the last 3 months), ongoing or planned participation in other treatment study protocols for epilepsy
* Contraindication for intracranial surgery
Staccato Loxapine Pulmonary Safety in Healthy Volunteers

The objective of this trial is to assess the pulmonary safety of 2 inhaled doses of Staccato Loxapine within a day.

The planned study is a multiple dose, double-blind, placebo-controlled, randomized, 2-sequence, 2-period crossover study investigating pulmonary safety in healthy volunteers.

Eligibility Criteria:
Inclusion Criteria:

* nonsmoker subjects in good general health with normal spirometry at screening AND baseline

Exclusion Criteria:

* history of asthma, COPD, or any other acute or chronic pulmonary disease or bronchodilator use
Xenogenic Keratoplasty From Porcine Cornea

Acellular porcine cornea is a valid substitution for human cornea because of its similar biological structure, corneal superficial curvature and good histocompatibility toward human. Facing the lack of human cornea donor, it is hypothesised that using acellular lamellar porcine cornea as an alternative of lamellar human cornea to treat infectious corneal ulcer.

Acellular porcine cornea eligibility criteria:

1. fresh porcine cornea,
2. porcine cornea keeping transparent without scar, neovascularization or corneal ulcer,
3. porcine cornea keeping integrative corneal epithelium and endothelium,
4. acellular porcine cornea keeping transparent.

Eligibility Criteria:
Inclusion Criteria:

* Patients with severe infectious corneal ulcer
* The ulcers can not be controlled with existing antibiotics eye drops or medicine after 1 week treatment
* The infected corneas have risks of penetrating
* The depth of ulcers are less than 400um
* The bridge of the ulcers is away from corneal limbal more than 1mm
* Patients aged 18 or older
* Patients able and willing to sign the informed consent form

Exclusion Criteria:

* Patients with severe infectious corneal ulcer in stable stage
* Patients with corneal ulcers after viruses infection, such as herpes simplex virus
* Patients with corneal ulcers from non-infectious factors, such as toxicity, burn or immunological inflammation
* The ulcers are not cover pupil zone and will not result in visional defect in future
* The depth of ulcer is less than 50um
* Patients has history of keratoplasty surgery
Painless Myocardial Ischemia in Diabetic Patients.

This study aims to investigate the relationship between the concentrations of blood orphanin, norepinephrine and the morbidity of painless myocardial ischemia in patients with diabetes mellitus. Hopefully, the biomarker(s) in the blood of diabetic patients can be found for screening high risk patients in the diabetes sufferers to prevent the painless myocardial ischemia.


Eligibility Criteria:
Inclusion Criteria:

* Subject has diabetes

Exclusion Criteria:

* History of myocardial ischemia
* Symptoms of myocardial ischemia（ECG changes except）
A Late Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes

The purpose of this study is to evaluate the efficacy and safety of KCT-0809 compared to placebo in patients with dry eye syndromes.


Eligibility Criteria:
Inclusion Criteria:

* Corneal and conjunctival damage
* Insufficiency of lacrimal secretion
* Ocular symptom

Exclusion Criteria:

* Severe ophthalmic disorder
* Punctual plugs or surgery for occlusion of the lacrimal puncta