cyrilzakka/clinical-trials huggingface dataset:
Virtual Reality for Panic Disorder With Agoraphobia

Panic disorder with agoraphobia (PDA) is associated with considerable personal distress, functional disability and societal costs. A large number of studies have shown that Cognitive Behavior Therapy (CBT) is a highly effective treatment for PDA. However, the CBT-protocols proven to be most effective involves repeated exposure to the particular environments the agoraphobic patient fears such as trains, tunnels, lifts and shops. This cause great practical problems for health care services as such therapeutic efforts involves spending considerable time outside the clinic. For primary care services this is particularly challenging due to the large number of patients expected to be seen. Normally clinicians meet up to 7 patients daily which makes it almost practically impossible to offer 2-hour sessions, which is necessary to carry out the relevant exposure tasks. Hence, the treatment proven to be most effective, which primary care services are commissioned to deliver, is too comprehensive and time consuming to be applied in real practice.

The investigators believe that a possible solution to the above problem is to provide evidence-based CBT but with the exposure components carried out through Virtual Reality (VR) rather than in vivo. Some research has already been done with virtual reality and exposure therapy for anxiety disorders with promising results. The aim of this pilot study is to treat patients with agoraphobia with or with a history of panic disorder with a standardized exposure-based CBT-protocol through VR. The virtual environments that are used for the study are live sequences filmed in 360°. The investigators hypothesize that CBT with VR will be effective and lead to improvements on measures of panic disorder and agoraphobia.


Eligibility Criteria:
Inclusion:

* A primary diagnosis of Agoraphobia with or with a history of panic disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5).
* Minimum 18 years of age.
* Able to read and write in Swedish

Exclusion:

* Other primary axis-I disorder
* Ongoing substance abuse or addiction
* Current or previous episode of psychosis or bipolar disorder
* Severe major depressive disorder:
* Moderate to severe suicidal risk
* Non-stable antidepressant medication (changed during the last month) or not agreeing to keep dosage constant throughout the study
* Ongoing concurrent psychological treatment
* Having received previous high quality Cognitive Therapy or Cognitive Behavior Therapy for agoraphobia during the recent year
Effect of Taurine on Portal Hemodynamics in Patients With Advanced Liver Cirrhosis

The investigators want to analyze the effect of Taurin on portal hemodynamics in patients with advanced liver cirrhosis.

28 days of 6 grams Taurine versus Placebo (randomization 1:1).

Eligibility Criteria:
Inclusion Criteria:

* Patients (male and female) aged older than 18 years with advanced liver cirrhosis (Child's Grade B and Child's Grade C), regardless of the disease origin (viral, alcoholic, idiopathic), who are scheduled for hepatic hemodynamic investigation
* Negative pregnancy test of women with childbearing potential
* Patient without beta blocker therapy: due to: intolerance of the medication, preexisting contraindication against beta blocker therapy, endoscopic band ligation as prophylaxis

Exclusion Criteria:

* History of variceal bleeding without endoscopic band ligation
* History of endoscopically diagnosed large varices with red spots without previous bleeding and without endoscopic band ligation
* HVPG \< 10 mmHg
* HVPG \> 20 mmHg and varices, unless ligated and treated in an eradication program within 6 months
* Beta Blocker therapy
* History of hypersensitivity to the trial drugs and contrast agent or to drugs with similar chemical structure
* Treatment with vasoactive or non-steroidal anti-inflammatory drugs or systematic antibiotics one week before the study
* Exclusion criteria for hepatic hemodynamic investigation
* Cardiac, renal or respiratory failure
* Previous surgical or transjugular intrahepatic portosystemic shunt
* Breast-feeding or pregnant women
Evaluation and Risk Factors of Post-traumatic Endophthalmitis

1. identify the incidence of post-traumatic endophthalmitis and the related risk factors influencing its development.
2. study the clinical- microbiological profile and evaluate the functional and anatomical outcomes of post-traumatic endophthalmitis (PPTE).


Eligibility Criteria:
Inclusion Criteria:

* Patients exposed to eye trauma and developed post-traumatic endophthalmitis

Exclusion Criteria:

* Patients who refuse to sign informed consent in this study
Post-Marketing Follow-Up of Long-term Type Ureteral Stent Set

Ureteral stents have been widely used in many urological operations. Although there are several reports regarding the effectiveness of long-term ureteral stents for malignancy ureteral obstruction, ureteral stricture and urolithiasis, the experience is limited about the long-term ureteral stents made by Taiwan. The investigators have to propose the 5-year post-market survey report. Though this observation study, The investigators can further understand the clinical safety and effectiveness of placing ureteral stents

Ureteral stents have been widely used in many urological operations. The main purposes of placing ureteral stents include improvement of ureteral obstruction, protecting renal function and drainage of infection. Although there are several reports regarding the effectiveness of long-term ureteral stents for malignancy ureteral obstruction, ureteral stricture and urolithiasis, the experience is limited about the long-term ureteral stents made by Taiwan. Thus, The investigators will conduct this post-marketing survey to observe and investigate the changes of ureteral stents, e.g. hydronephrosis, infection and stone formation. Now this product has been approved by European Medical Device Administration. The investigators have to propose the 5-year post-market survey report. Though this observation study, The investigators can further understand the clinical safety and effectiveness of placing ureteral stents

Eligibility Criteria:
Inclusion Criteria:

1. Patients who used " Bioteq" Ureteral Stent Set (Long-Term Type) in their treatments.
2. Patients with complete basic parameters.

Exclusion Criteria:

1. Patients with any of the following conditions are excluded from this clinical study:

   Patients with incomplete basic parameters.
2. The minorities, children and special populations
Transitioning Care: Perspectives of Older Women With Early Breast Cancer on Current Telemedicine Modalities

Explosive growth in the use of telemedicine (video or telephone visits) has followed the onset of the coronavirus disease 2019 (COVID-19) pandemic in order to meet healthcare needs while avoiding unnecessary exposure risks in ambulatory care spaces. Accordingly, in March 2020, the Centers for Medicare \& Medicaid Services expanded reimbursement for telemedicine visits to equal that of in-person services. The policy and infrastructure that enabled this emergency transition is laying the groundwork for enduring expansion of elective telemedicine, a technology that could significantly decrease the burden of medical care in older patients with cancer. To benefit from telehealth, patients must have a certain level of knowledge and capacity to engage with technology, which can be a challenge for some older adults because of inexperience, access, and disability. As cancer is mainly a disease of older adults, with a median age of 65 at diagnosis for most cancer types, this is a significant limitation on the utility of telemedicine in oncology.

The goal of our study is to better understand older breast cancer patients' experiences with telephone and video telemedicine with regard to visit convenience, completeness, and interpersonal satisfaction through semi-structured interviews with patients.

Methods:

30 participants will be consented in this study. 20 will have participated in video telemedicine appointments with their treating breast cancer oncologists, and 10 will have used telephone. Semi-structured interviews lasting no more than 30 minutes will be conducted to ascertain the participant's (1) reason for choosing a certain telemedicine modality, (2) perception of telemedicine visit convenience, completeness, and interpersonal satisfaction compared to in-person visits, and (3) use of peripheral virtual support from healthcare team, such as messaging in MyChart. After the interview has been conducted, the patient will be asked complete the patient-reported portion of the Geriatric Assessment (GA) either through an internet link, or verbally with the research staff reading the questions and recording the answers. Data pertaining to the participant's breast cancer diagnosis and treatment will be extracted from Epic@UNC.

Eligibility Criteria:
Inclusion Criteria:

* female
* age 65 or older
* diagnosed with early breast cancer (Stage I-III)
* completed primary treatment (surgery, chemotherapy, radiation treatment)
* received in-person outpatient care at North Caroline Cancer Hospital before transitioning to telemedicine after March 2020
* providing written informed consent
* able to understand and speak English.

Exclusion Criteria:

* Patients who do not meet the inclusion criteria stated above will be excluded. There will be no further exclusion criteria.
a Lifestyle Intervention Programme Using Mobile Application vs Booklet for Adults With Metabolic Syndrome

The study aims to compare the effect of a lifestyle intervention programme (LIP) using mobile application (MetS app) vs using booklet for MetS adults living in the community.

The study aims to compare the effect of a lifestyle intervention programme (LIP) using mobile application (MetS app) vs using booklet for MetS adults living in the community.

Methods A multi-site randomized controlled trial (RCT) with three arms, namely, MetS app group (Group A), booklet group (Group B), and control group (group C). Three hundred and sixty subjects will be recruited from six community centers and randomized into either one arm. Inclusion criteria are those MetS adult, able to use a smart phone. Group a participants will receive a 30-minute educational session and a MetS app while Group B will receive same educational session and a MetS booklet and the control group receive a placebo booklet only. The MetS app or booklet, has been well developed by the team with the support of internal grant, aims to support MetS individual's self- monitoring and record of health measures (body weight, blood pressure, waist circumference) and exercise. The primary outcomes of this study include the body weight and total physical exercise (GSLTPAQ). The secondary outcomes include cardiometabolic risk factors, cardiovascular endurance, self-efficacy for exercise (SEE) and stress level (PSS-10). Data will be collected at baseline (T1), 4 week (T2) and week 12 (T3) and week 24 (T4). SPSS and Generalized Estimating equations (GEE) model will be employed for data analysis.

Significance This study will provide empirical evidence and inform about the effective way to enhance patient's self-management of MetS, exercise sustainability that will be beneficial to clients' health.

Eligibility Criteria:
Inclusion Criteria:

1. Ethnic Chinese client who has a smart phone.
2. Adult age 18 or over
3. MetS Clients with central obesity (male \>90 cm , female \> 80cm ) plus two items of the followings :

   * Raised triglycerides ≥ 150 mg/dL (1.7 mmol/L) or specific treatment for this lipid abnormality
   * Reduced HDL cholesterol \< 40 mg/dL (1.03 mmol/L) in males \< 50 mg/dL (1.29 mmol/L) in females or treatment for this lipid abnormality
   * Raised blood pressure systolic BP ≥ 130 or diastolic BP ≥ 85 mm Hg or treatment of previously diagnosed hypertension (HT)
4. Raised fasting plasma glucose (FPG) ≥ 100 mg/dL (5.6 mmol/L), or previously diagnosed type 2 diabetes (DM) -

Exclusion Criteria:

* Clients with physical, mental, visual, or cognitive impairments with regular medical follow-ups and treatment, and those who have musculoskeletal disorders or other disabling diseases that may limit the practice of walking exercise will be excluded. Client receiving prescription of medication for weight reduction will be excluded as well.
Impact of Prokinetic Use After Emergency Intestinal Anastomosis on Postoperative Clinical Outcomes

Prokinetic drugs used to accelerate healing of intestinal anastomosis of urgent cases which not prepared preoperative by increase intestinal motility and gastric emptying and decrease postoperative adhesions They are many types of prokinetics as cholinergic agonists, dopamine antagonist, serotonergic agonists and macrolides Agents of prokinetics administered immediately post operation and at the time of hospitalization

By evaluation the effect of prokinetic use versus non use after emergency intestinal intestinal anastomosis on short and long term clinical outcome It will be prospective cohort study which conducted in sohag university hospital Study will include patients presented with urgent anastomosis Inclusion criteria: all adults underwent emergency intestinal anastomosis Exclusion criteria: pediatrics, patients with comorbidities and patients with electively resection and anastomosis.

Primary goals are to detect effect of prokinetics on incidence of leakage rate Secondary outcomes include early bowel opening, enteral feeding, post operative pain, wound infection and adhesion formation rate.

Eligibility Criteria:
Inclusion Criteria:

* all adult patients

Exclusion Criteria:

* pediatrics
* patients associated with comorbidities
* patients with electively resection and anastomosis
Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers

The purpose of this study is to determine if there is a correlation between tumor response after 3 doses of chemotherapy by induction using Docetaxel, Cisplatine and 5-Fluorouracile for advanced stage epidermoid carcinomas of the upper aero digestive tract and the presence of one or a combination of 3 genetic polymorphisms and/or 5 intra-tumoral transcriptional modifications.


Eligibility Criteria:
Inclusion Criteria:

* Squamous cell carcinoma originating in the mouth, oropharynx, larynx or hypopharynx has been histologically documented.
* The disease is at one of the following UICC 2002 stages, regardless of ganglion status: T3 MO or T4 MO
* Treatment via chemotherapy, radiotherapy or surgery (except for the diagnostic biopsy) has not started
* The pluridisciplinary committee as ruled out surgical options for technical or functional reasons
* Absence of distant metastases
* OMS general health status between 0 and 2
* Patient has given informed consent
* Patient is affiliated with a social security system

Exclusion Criteria:

* Undifferentiated squamous cell carcinomas in the nasopharynx (UCNT)
* Another cancer priorly treated with one of the following chemotherapies: Docetaxel, Cisplatin, 5-Fluorouracile
* Creatininemia \> 2 mg/dl and/or creatinine clearance \< 60ml/min
* Patient under guardianship
* Presence of another severe pathology including:

  * severe or chronic cardiac, renal and/or hepatic insufficiencies
  * severe medullary hypoplasia
  * severe autoimmune disease
  * psychosis or senility
Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey

Nationwide descriptive epidemiology survey aiming to determine lower limb OA prevalence, based on a validated method previously used to assess inflammatory rheumatism (rheumatoid arthritis and spondylarthropathy) prevalence in France.

Osteoarthritis (OA) is a degenerative disease progressively affecting joint cartilage and subchondral bone, leading to pain, limited range of motion and functional impairment. Knee and hip are the more frequently affected joints. There is no treatment able to cure OA or at least to slow down cartilage damage. Thus, when symptomatic treatments become ineffective, joint prosthetic replacement is the unique solution.

There is a substantial lack of information about osteoarthritis (OA) epidemiology in France, as well as in other European countries, which becomes more and more critical with population aging. The need for additional knowledge was outlined in the law about public health priorities in France, published on August 9th, 2004. In this document, a specific call is made for additional investigation on functional limitations, disability and quality of life modification of people affected by OA.

Up to now, available information is mainly limited to short- or medium-term studies, conducted in clinic-based samples. Thus, based on demography and public health conclusions, implementing population-based epidemiologic studies is required in order to improve scientific knowledge with regards to :

* prevalence of symptomatic OA,
* its natural history over years and potential prognostic factors influencing the disease,
* its impact in terms of quality of life changes, disability, lack of autonomy and health resource use.

Our expert group, which has a substantial experience in osteoarthritis, epidemiology and health service research, has developed a 2-part research program aiming to help answering to OA-related public health questions:

* Part 1: a nationwide descriptive epidemiology survey aiming to determine lower limb OA prevalence, based on a validated method previously used to assess inflammatory rheumatism (rheumatoid arthritis and spondylarthropathy) prevalence in France.
* Part 2: the constitution of a population-based cohort of OA patients, aiming to collect clinical, biologic and radiological data about OA natural history, predictors of structural progression, consequences on quality of life, function and health resource use.

The present study is the part 1 of the program

Eligibility Criteria:
Inclusion Criteria:

* age 40-75
* adults in households representative of the French population for age, sex, area of living and number of household members.

Exclusion Criteria:
Effects of Combined Exercises on Primary Dysmenorrhea

Dysmenorrhea is one of the most common gynecological problem in adolescents and young women. Symptoms of dysmenorrhea include pelvic / abdominal pain, back pain, headache, nausea, vomiting, diarrhea. These symptoms occur before menstrual bleeding or with bleeding and lasts in 12-74 hours. The objective of this study to investigate the effects of combined exercises on dysmenorrhea symptoms. Exercise protocol aerobic, stretching, kegels, pelvic motions and relaxation exercises.

Women with a positive primary dysmenorrhoea symptom between 18 and 30 years of age living in the Turkish Republic of Northern Cyprus will be included in the study. According to the result of the power analysis, 14 subjet for control and 14subjet intervention group were decided.

The eligibility criteria for this study are:

* The Visual Analogue Scale value is at least 5 per day when the dysmenorrhea symptoms are the most painful,
* To have the regular menstrual cycle (24-35 days),
* To be sedentary

The exclusion criteria for this study are:

* Women with secondary dysmenorrhea,
* The women who gave birth or abortion,
* People with active sexual experience,
* Women who use intrauterine devices,
* Individuals with regular drug use,
* Serious psychological problems
* Acute musculoskeletal problems,
* People with neurological or cardiopulmonary disease

This research will consist of exercise and control groups. An exercise protocol consisting of a combination of various exercises will be applied to the exercise group and no exercises will be done for the control group. women in the exercise group will perform two menstrual cycles, three times a week in the presence of a physiotherapist.

Assessments will be made on the day that the symptoms are seen to be the most severe in order to determine the symptoms of the women in both groups. After baseline assements exercises will start at 3rd day of cycle. Assesments will repeat at second and third menstrual bleedings.

Visual Analogue Scale, Menstrual symptom questionnarie and Pittsburgh Sleep Quality Index will be use.

Eligibility Criteria:
Inclusion Criteria:

* The Visual Analogue Scale value is at least 5 per day when the dysmenorrhea symptoms are the most painful,
* To have the regular menstrual cycle (24-35 days),
* Being a sedentary (not participating in any regular exercise program).

Exclusion Criteria:

* Women with secondary dysmenorrhea,
* The women who gave birth or abortion,
* People with active sexual experience,
* Women who use intrauterine devices,
* Individuals with regular drug use,
* Serious psychological problems
* Acute musculoskeletal problems,
* People with neurological or cardiopulmonary disease.
CPAP (Continuous Positive Airway Pressure) Study Educational Materials and Usage Feedback to Promote CPAP Adherence

The study hypothesis: in groups receiving tailored education and feedback in a style that matches their psychological profile, will show a higher CPAP adherence rates than groups receiving mismatched tailored education / feedback, and groups that receive no tailored education and feedback (standard of care).

Three group, randomized, controlled clinical trial assessing the extent to which tailoring a CPAP intervention entailing education and feedback to the psychological profile of new CPAP users can enhance the impact of the intervention in terms of adherence-related behavior.

Eligibility Criteria:
Inclusion Criteria:

* Males or females, ages 21-80 years
* Prescribed to start CPAP treatment and diagnosed with mild to severe OSA.
* Recently (within study period) diagnosed with Mild to Severe OSA defined as an Apnea-Hypopnea Index of equal to or greater than 10 events per hour of sleep.
* CPAP treatment naïve

Exclusion Criteria:

* Inability to provide informed consent
* Presence of a comorbid condition that may potentially complicate CPAP adherence, such as:

  * Unstable depressive disorder
  * Unstable anxiety disorder
  * Dementia
  * Unable to understand study information
  * Obesity Hypoventilation Syndrome
  * Central Sleep Apnea or Complex Sleep Apnea
  * Facial musculoskeletal disorder

    * Unwillingness or inability to use CPAP therapy
    * Unable to return for follow up appointment
    * Use of supplemental oxygen
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

The aim of this study is to compare progression free survival (PFS) in treatment-naïve Participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC) receiving sotorasib, panitumumab and FOLFIRI vs FOLFIRI with or without bevacizumab-awwb.


Eligibility Criteria:
Inclusion Criteria:

* Pathologically documented metastatic colorectal adenocarcinoma with KRAS p.G12C mutation by a locally validated assay.
* Central confirmation of KRAS p.G12C mutation
* Measurable metastatic disease per RECIST v1.1 criteria.
* Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1.
* Adequate organ function.

Exclusion Criteria:

* Active, untreated brain metastases.
* Leptomeningeal disease
* Previous treatment with a KRAS p.G12C inhibitor
* History of interstitial pneumonitis or pulmonary fibrosis or evidence of interstitial pneumonitis or pulmonary fibrosis on baseline CT scan