cyrilzakka/clinical-trials huggingface dataset:
Efficacy and Safety of Danzhen

The purpose is to evaluate the effectiveness and safety profile of Danzhen for the prophylaxis of migraine in a "real-world" setting.

In adults between 18- and 65-years in China,the prevalence of migraine is 9.3% in general. Migraine is a heterogeneous condition that may produce a range of symptom profiles and various degrees of disability.The disability resulting from migraine can be severe imposing a considerable health burden upon the sufferer and society. The purpose of this study, using topiramate as the control, is to evaluate the effectiveness and safety of Danzhen for the prophylaxis of migraine in a "real-world"setting.Patients are asked to maintain a detailed headache diary via headache diary APP throughout the treatment period.

Eligibility Criteria:
Inclusion Criteria:

* Patients older than or equal to 18 years and less than 70 years.
* The diagnosis of migraine is made according to 2004 The International Classification of Headache Disorders: 2nd edition (ICHD-II) .
* Consent form signed by the participant or his/her authorized surrogate.

Exclusion Criteria:

* Patients had primary or secondary headache disorders other than migraine.
* Female subjects of childbearing age will be excluded if they were pregnant, lactating or planning apregnancy in the next year or if they were not using an adequate form of birth control.
* Patients will be excluded if they had significant medical or psychiatric disease,or taking another antidepressant for any reason and not able to discontinue.
* Patients used other preventive pharmacological agents during the 1 month prior to baseline period.
Immunotherapy of CD8+NKG2D+ AKT Cell With Chemotherapy to Pancreatic Cancer

A Prospective Study on the Efficacy and Safety of CD8+NKG2D+ AKT cell immunotherapy to the pancreatic cancer patients treated with adjuvant chemotherapy.


Eligibility Criteria:
Inclusion Criteria:

* 1. Diagnosed as stage II-III pancreatic ductal adenocarcinoma patients by pathologic histology;
* 2. Pancreatic cancer after radical resection;
* 3. Eastern Cooperative Oncology Group Performance Status less than 2;
* 4. Without radiotherapy or neoadjuvant chemotherapy;
* 5. The man or the gestation and lactation women Age between 18 to 80 years old;
* 6. Bone marrow functioned well: ANC more than 1.5\*10\^9/ L, PLT more than 100\*10\^9/LHgb more than 9 g/dL;
* 7. Blood biochemical indicators: AST（SGOT）less than 1.5 ULNALT（SGPT）less than 1.5 ULN, TBIL less than 1.5 ULN;
* 8. PT and PPT are in normal ranges;
* 9. Three months prior to clinical research did not receive any other clinical research trials;
* 10. patients are voluntary, and willing to sign informed consent.

Exclusion Criteria:

* 1. Patients with other malignant tumors in the past five years;
* 2. Active viral or bacterial infection and cannot be controlled with appropriate anti-infection treatment;
* 3. Known as HIV infection, active hepatitis B virus or hepatitis C virus infection;
* 4. Known allergy to any kind of component of study drugs;
* 5. History of connective tissue disease(Such as lupus, scleroderma, nodular arteritis);
* 6. Patients with a history of interstitial pneumoniaSlowly progressive difficulty in breathing and hoose Sarcoidosissilicosis Fibrose pulmonaire idiopathiquehylactic pneumonia or A variety of allergy;
* 7. Suffering from mental illness or other illness, such as heart or lung disease, diabetes, etc. that can not be controlled, and can not cope with study treatment and monitoring requirements;
* 8. At the same time Patients participate in any other use of interventional medicine clinical research or checkers.
Effect of Mirror Therapy on the Arteriovenous Fistula Cannulation-related Pain and Anxiety

Pharmacological and non-pharmacological methods are frequently used to reduce cannulation-related pain in patients with fistulas. Non-pharmacological approaches have been more favored than pharmacological approaches for some reasons, including ease of use and fewer side effects. Patients describe worry about the success of needling and resigned acceptance of pain and anxiety about dialysis needles. With this background in mind, mirror therapy has been introduced as one of the non-pharmacological interventions in the domain of pain management.

Patients undergoing hemodialysis experience pain, anxiety and stress due to large-gauge needle punctures necessary to ensure efficient arteriovenous fistula flow. In addition, anxiety disorders are prevalent in hemodialysis patients, primarily caused by invasive procedures and dialysis machine alarm sounds. Patients describe worry about the success of needling and resigned acceptance of pain and anxiety about dialysis needles. Therefore, when performing an AVF puncture, nursing care should prioritise the management of pain and anxiety. With this background in mind, mirror therapy has been introduced as one of the non-pharmacological interventions in the domain of pain management. It has been reported that viewing the picture of a healthy limb could moderate pain perception in the affected one

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 years and older
* Patients who received hemodialysis (HD) treatment with an arteriovenous fistula (AVF) for at least 3 months
* Patients receiving HD treatment 3 days a week for 4 hours each session
* Patients with a pain score of ⩾1 during AVF cannulation, measured by a visual analog scale (VAS)
* Patients able to communicate in Turkish
* Patients without psychiatric disorders that impair communication
* Patients who agreed to participate in the study

Exclusion Criteria:

* Patients who were known to present difficulties with fistula cannulation (requiring multiple cannulations)
* Patients with a history of hematoma or stenosis in the arteriovenous fistula (AVF)
* Patients with an infection at the fistula site
* Patients who took painkillers within 3 hours prior to treatment
* Patients unable to maintain a sitting position on the bed
* Patients with low vision or visual disturbances (30 cm or less)
* Patients who did not wish to participate in the study
Early Detection of Prostate Cancer by FACS

Early detection of prostrate cancer and development of metastases. The research will attempt to match the SCM test (structuredness of the cytoplasmic matrix) in lymphocytes as an early cancer detection test using Florescent Activated Cell Sorting (FACS) as a replacement for the CellScan instrument. The test is based on measurement of cellular changes in response to the specific prostate antigen, PSA.


Eligibility Criteria:
Inclusion Criteria:

Experimental group : Males between the ages of 60-90 years, with medical diagnosis of prostate cancer according to both clinical and hematological examinations, before receiving any medical treatment.

Control Group 1: Males between the ages of 60-90 years, with diagnosed benign prostate hyperplasia -BPH.

Control Group 2: Males between the ages of 60-90 years, medically diagnosed as healthy.

Control Group 3: Males between the ages of 60-90 years, medically diagnosed with another form of cancer, not prostate.

Exclusion Criteria:

Experimental group: Other known cancer or systemic infection. Control Group 1: Other known cancer or systemic infection. Control Group 2:Past hematological disorders nor cancer growth history. other known systemic infection, nor urinary tract infection. Patients hospitalized for orthopedic injuries of any type who are otherwise free of urinary tract infections.

Control Group 3:Other known systemic infection, nor urinary tract infection.

-
Physical Function and Activities of Daily Living in Cancer Patients During Chemotherapy

The study is a randomized controlled trial with the aim to examine the feasibility and the effects of a home-based exercise intervention program on activities of daily living (ADL) in patients with advanced gastrointestinal cancer undergoing chemotherapeutic treatment. Further outcomes include functional and body status, quality of life, body composition, and chemotherapy completion rate. Study participants will be randomized to an exercise intervention group or a wait-list control group

A randomised longitudinal study. A total of 44 gastrointestinal cancer patients before their first-line chemotherapy are recruited and randomised into one of two treatment groups A: Home based- physical activity or B: wait-control. The intervention period is 12 weeks. Primary outcome are the ADLs (iADL 1-8; FIM 1-7).Secondary outcomes are the physical activity, quality of life, peripheral polyneuropathy, chemotherapy regimen, gait speed, postural stability, maximal isometric voluntary force of the upper extremity, Maximal isometric voluntary force (MIVF) and strength endurance of the lower extremity, nutritional state, body composition and perceive functional ability. All measurements are standardized and are performed before chemotherapy, after 2 cycles of chemotherapy (4-6weeks) and after 12 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Histologically classified gastrointestinal cancer
* UICC III-IV
* Prior to (planned) first-line chemotherapy (curative und palliative)
* ≥50 years

Exclusion Criteria:

* ECOG \> 2
* Systemic diseases (MS, ALS)
* disorders (neurological, skeletal, muscular, mental or cognitive) or drug use (irrespective of the cancer therapy) that may affect gait, balance or muscular strength
* chronic infection, uncontrolled hypertension (diastolic pressure over 95 mmHg)
* vestibulopathies
* uncorrected visual deficits
Effect of Early Range of Motion Following First Time Patellar Dislocation

Do teen-age patients with a dislocated knee cap do better with or without a brace?

This study will look at two different ways to treat teen-age patients who have had a dislocation of their knee cap. Both groups will receive the physical therapy treatment for knee cap dislocation but one group will first be in a brace for a week and the other group will start moving in therapy right away.

Eligibility Criteria:
Inclusion Criteria:

* Male and female adolescents between 11-17 years
* Medical diagnosis of 1st time lateral patellar instability episode (dislocation or subluxation)
* Subjective history of knee shifting, instability, popping out, knee effusion
* Apprehension test is positive and has medial patellar tenderness
* Referred to the Texas Children's Hospital (TCH) outpatient sports medicine clinic from an emergency room facility, urgent care or pediatrician within 10 days of the injury.
* Free of co-morbidities that would prevent or limit rehabilitation including cardiac, pulmonary, psychiatric (except Attention Deficit Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD), orthopedic, neurological
* Must be able to follow directions and participate in rehabilitation protocol for the 3-month study period.

Exclusion Criteria:

* Imaging or clinical findings suggest surgical intervention is needed i.e. fracture, osteochondral defect, Lachman or other positive knee ligament special tests.
A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer SES Safety and Effectiveness in CAD Treatment

research topic:helios After registration of clinical research bidders:kinhely bio-tech Co.Ltd study design:A prospective single treatment group multicenter clinical study Number of patients:Included in the subjects of 800 cases Main research purpose:Evaluation of safety and effectiveness Mainly studies the finish:1 year target lesion of the failure

Inclusion criteria :

one:Gender not limited at the age of 18 to 80 two:myocardial ischemia or angina symptoms of coronary artery disease three:A narrow is less than 50% treated with stents four:Comply with the instructions five:Voluntarily signed the informed consent form exclusion criteria: one:Pregnant women two:cardiac shock three:Against a suppository medicines or allergies four:Participated in other test research in the first 6 months five:Within 6 months after PCI plans to accept non cardiac surgery six:Non-compliant patient Follow-up time:A month for 6 months and 9 months to 1 year to 2 years follow-up progress plan:All center within 6 months after start of complete into the group

no desired

Eligibility Criteria:
Inclusion Criteria:

* Any age 18 to 80 sex Myocardial ischemia or angina pectoris of coronary artery disease An application stents diameter stenosis greater than 50% Comply with the instructions Voluntarily signed the informed consent form

Exclusion Criteria:

* Pregnant women cardiac shock Intolerance to antithrombotic therapy or allergies 6 months prior to the start of the study involved in other studies Within 6 months after PCI plans to accept non cardiac surgery Non-compliant patient
Small Airway Chronic Obstructive Disease Syndrome Following Exposure to WTC Dust

Many "Survivors" in the World Trade Center (WTC) clinical program have a clinical syndrome characterized by chronic obstruction in small airways and persistence of lower respiratory symptoms despite therapy. This study will test the hypothesis that persistent symptoms in WTC "Survivors" are associated with abnormal small airways whose dysfunction is amplified during exercise and is associated with biologic evidence of inflammation and remodeling. The results from this study will have important treatment implications for our WTC population with potential applicability to larger populations with either inhalational lung injury and/or airway diseases such as asthma and chronic obstructive pulmonary disease.


Eligibility Criteria:
Inclusion Criteria:

sACOS patients

* Previously participated in ULRS study and signed consent to be recontacted, or
* Patient in the WTC EHC and signed consent to be recontacted
* Onset of lower respiratory symptoms (LRS) after 9/11/01
* ACT \< 20 at WTC EHC Monitoring visit
* Presence of LRS on Study Visit 1
* ACT\<20 at Study Visit 1
* FEV1 \> 70% predicted Study Visit 1
* Using ICS/LABA (Advair HFA equivalent \> 115/21 mcg bid) or Fluticasone (110 mcg bid or equivalent) for at least 1 month before Study Visit 1
* CXR without parenchymal abnormalities

Control

* Patient in the WTC EHC and signed consent to be recontacted
* of lower respiratory symptoms on WTC EHC Monitoring Visit of WTC EHC
* Absence of lower respiratory symptoms on Study Visit 1
* FEV1 \> 70% predicted on monitoring
* Not on any ICS/LABA/LAMA

Exclusion Criteria:

sACOS

* \>10py tobacco use
* Unstable cardiac disease
* Systolic BP \> 180 mmHg or Diastolic BP \> 120 mmHg
* Oxygen saturation \< 90%
* Uncontrolled HTN, DM
* Musculoskeletal inability to exercise
* Use of long acting muscarinic antagonist in the past 2 weeks
* Current use of oral corticosteroids
* Other pulmonary disease, including sarcoidosis, ILD
* Currently pregnant or with plans to become pregnant or lactating
* History of narrow angle glaucoma
* Known prostate hyperplasia or bladder-neck obstruction

Control

* \>10py tobacco use
* Unstable cardiac disease
* Systolic BP \> 180 mmHg or Diastolic BP \> 120 mmHg
* Oxygen saturation \< 90%
* Uncontrolled HTN, DM
* Musculoskeletal inability to exercise
* Use of ICS/LABA/SABA/LAMA individually or in combined formulation
* Current use of oral corticosteroids
* Other pulmonary disease, including sarcoidosis, ILD
* Currently pregnant or with plans to become pregnant or lactating
* History of narrow angle glaucoma
* Known prostate hyperplasia or bladder-neck obstruction
Docosahexaenoic Acid on Breath Holding Spells in Children

DHA on Breath Holding Spells

Effect of DHA on Breath Holding Spells

Eligibility Criteria:
Inclusion Criteria:

* Children with newly diagnosed sprlls

Exclusion Criteria Other treatment as iron and piracetam
Efficacy of WB-EMS in Frail Older People

Exercise in general and resistance training (RT) in particular have demonstrated positive effects on frailty outcomes, including physical functioning. However, frail older people with functional impairments are among the least physically active and have problems reaching high-intensity levels. Whole-body electromyostimulation (WB-EMS) allows the simultaneous innervation of all large muscle groups by external electrical stimulation, inducing a high-intensity RT at a low subjective effort level. The efficacy of WB-EMS in frail older people has yet to be determined.

The primary objective of this study is to investigate the efficacy of WB-EMS in frail older people.


Eligibility Criteria:
Inclusion Criteria:

* aged 65 years and older
* frail according to Tilburg Frailty Indicator
* residing in assisted living facility or nursing home
* able to walk 4m w/o walking aid but without personal assistance
* no prior WB-EMS exposure

Exclusion Criteria:

* severe visual or hearing impairments
* major cognitive impairment (MMSE \<10)
* medications with muscle-anabolic effects
* medical conditions affecting trainability of muscles (e.g. Myasthenia gravis, Cushing syndrome, Morbus McArdle)
* surgery within past two months
* history of rhabdomyolysis
* medical conditions affecting sensation of electrical stimuli (e.g. severe polyneuropathy)
* severe renal insufficiency (eGFR\<30 ml/min/1.73m²)
* electronic implants
* acute or untreated abdominal wall or inguinal hernia
* Ventricular arrhythmias requiring therapy
Effectiveness of Chronic Kidney Disease Nurse-led Self-management Program (CKD-NLSM)

This study aims to develop, implement and evaluate the effectiveness of a theory-driven nurse-led self-management intervention program compared to standard usual care in people with CKD stages 3-4 on CKD knowledge, self-management behavior, self-efficacy and HRQoL using valid and reliable instruments in Malaysia.

Patients aged ≥ 18 years with CKD stages 3-4 will be recruited between July 2019 - October 2019. Participants will be randomly allocated into either the intervention (N = 77) or control group (N = 77). The control group will receive standard usual care, while the intervention group will receive standard usual care plus a self-management program delivered by renal nurse educators. The intervention will be guided by social cognitive theory and include group-based educational sessions, CKD booklet and follow-up phone calls. Both groups will be followed for 12 weeks. Data will be analyzed using SPSS version 25. The primary outcomes are improving in knowledge and self-management, while the secondary outcomes are improving in self-confidence, quality of life and clinical outcomes of the participants.

Eligibility Criteria:
Inclusion Criteria:

* The inclusion criteria are CKD (stages 3-4), aged ≥ 18 years, could speak, read, and understand Malay language, able to give informed consent, had never participated in any structured education program before, willing to participate in the study and most importantly not expected to start dialysis during the study.

Exclusion Criteria:

* Participants will be excluded if they had ESRD, were receiving dialysis or were cognitively impaired.
Parallel-Arm Study to Compare AD109 to Placebo With Patients With OSA (SynAIRgy Study)

This is a Phase 3 Randomized Double-Blind Placebo-Controlled 6-month Parallel-Arm Study to Compare a Fixed Dose Combination of AD109 to Placebo in Obstructive Sleep Apnea.


Eligibility Criteria:
Inclusion Criteria:

1. ≥18 years of age at the time of informed consent.
2. PSG criteria: AHI of ≥10 and ≤45; ≤ 25% central or mixed apneas; and PLM arousal index ≤15
3. PROMIS-Fatigue: raw score ≥17
4. PAP intolerance or current PAP refusal.
5. BMI between 18.5 and 40 kg/m2 for men, or 42 kg/m2 for women, inclusive.

Exclusion Criteria:

1. Narcolepsy, restless leg syndrome, REM sleep behavior disorder
2. Insomnia disorder characterized by difficulty initiating or maintaining sleep, or use within the past month of sedative-hypnotics or other medication for the purpose of treating or avoiding insomnia symptoms.
3. Pierre Robin, Treacher Collins, or other craniofacial malformation syndrome, or grade ≥3 tonsillar hypertrophy.
4. Clinically significant cardiac disease, e.g., ventricular arrhythmia, untreated or unstable coronary artery disease, cardiac failure. Stable atrial arrhythmia is allowed.
5. Neuromuscular disorder (e.g., motor neuron disease, muscular dystrophy or myopathy, myasthenic syndrome); epilepsy; Parkinson, Alzheimer, or other neurodegenerative disease.

Exclusion Criteria:

-
Promoting Physical Activity Behavior in Persons With Multiple Sclerosis

The purpose of this research study is to evaluate whether tailored print material can promote physical activity and exercise, and subsequently improve quality of life and fitness levels among people with multiple sclerosis (MS). Research suggests that routine physical activity is beneficial in people with mild to moderate MS. However, people with MS may face many barriers for engaging in regular physical activity. Prescribing a home exercise program and receiving tailored motivational print material may help people engage in physical activity. Thus, the investigators hope to figure out whether tailored print material can be used as strategy to promote physical activity and improve physical function in people with MS.

The objective of the proposed study is to further our understanding of methods to promote physical activity (PA) in people with multiple sclerosis (MS). The investigators will evaluate the efficacy of a print-based multifaceted intervention that consists of prescribing an exercise program and teaching self-management strategies.

Eligibility Criteria:
Inclusion Criteria:

* A physician-confirmed diagnosis of relapsing-remitting MS

Exclusion Criteria:

* Exercise more than 150 minutes per week
* Pregnant
* Metabolic or cardiopulmonary disease that puts patient at high risk for engaging in a home exercise program (patients with controlled diabetes and high blood pressure will still be considered eligible)
* Four or more falls in the past 6 months
* Be able to walk 25 feet with or without a cane
* Severe cognitive deficits
* Unable to read at a 6th grade level
* A condition besides MS that had lead to hospitalization in the past year
Lung Cancer Screening Using DNA Methylation Changes in Circulated Tumor and PBMC DNA

A central challenge in the fight against lung cancers is how to detect disease in a noninvasive manner before it is detectable by imaging methods. Although inroads have been made with more sensitive imaging techniques for earlier detection of breast and lung cancers, these techniques are limited by the size of lesion that could be detected. Alternatively, several blood proteomic biomarkers have been proposed but none offer as of yet sufficient predictive power. Consequently, effective non-invasive tools as prognostic indicators and biomarkers of lung cancer is urgently needed.

The purpose of this study is to develop and test non-invasive biomarkers based on methylation changes in PBMC and circulated tumor DNA in lung cancer patients.


Eligibility Criteria:
Inclusion Criteria:

* Histological confirmed lung cancer

Exclusion Criteria:

* Pregnant women
* Minors (subjects less than 18 years of age)
* Prisoners
* Patients with known infectious disease, such as human immunodeficiency virus (HIV), tuberculosis (TB), or hepatitis B, C
* Patients having other than one cancer
* Subjects unable to consent for themselves