cyrilzakka/clinical-trials huggingface dataset:
Computer Assisted Lessening of Intrusive Memories in the Emergency Department

During the COVID-19 pandemic, clinical staff working in frontline NHS hospital and pre-hospital departments (e.g. emergency department, intensive care unit, ambulance service) are being faced with difficult and stressful situations, which may be traumatic to them. Staff report high rates of post-traumatic stress symptoms, such as intrusive memories of these incidents, which 'pop into their mind' unexpectedly, are distressing and can impact on work performance. Currently there is a lack of tailored evidence-based interventions for staff struggling with intrusive memories of work-related traumatic events: simple, accessible, remotely-delivered interventions are needed. An intervention which has been found to be effective in reducing intrusive memories is a simple cognitive task that involves briefly bringing to mind the memory and then playing the computer game Tetris with specific ("mental rotation") instructions. This case series study aims to test the intervention in a group of 8-20 staff members working clinically in NHS hospital and pre-hospital departments. The intervention will be delivered remotely (via computer/smartphone/tablet/phone). Participants will record the number of intrusive memories daily over a 3-week period, with the intervention delivered after 1 week (with optional subsequent booster sessions). Symptoms of trauma, anxiety and depression will be assessed weekly over this period, and at 4 weeks after the intervention. It is predicted that participants will have fewer intrusive memories per day/week, and lower clinical symptoms scores, after completing the intervention than before completing the intervention. The study will also investigate how feasible and acceptable the intervention is for NHS staff. Findings will inform the next steps in developing and evaluating a digital intervention to reduce intrusive memories of work-related traumatic events in healthcare staff.


Eligibility Criteria:
Inclusion Criteria:

* aged 18 or above;
* able to read, write and speak in English;
* able and willing to provide informed consent and complete study procedures;
* NHS hospital and pre-hospital clinical staff; experiencing intrusive memories, which are problematic to them (self-report);
* reporting the occurrence of at least two intrusive memories of a work-related traumatic incident in the week prior to beginning the study;
* able and willing to talk about the intrusive memories;
* able and willing to complete an electronic Intrusion Diary over a 2-3 week period;
* able and willing to play Tetris on a hand-held device;
* not currently undergoing treatment for PTSD or its symptoms.

Exclusion Criteria:

* participants will be excluded if they have fewer than two targeted intrusive memories per week during the pre-intervention period;
* participants will be also excluded if they start undergoing treatment for PTSD or its symptoms during the course of the study.
Curcumin Bioavailability in Glioblastoma Patients

Measuring the bioavailability of orally administered curcumin in the tumors of glioblastoma patients.


Eligibility Criteria:
Inclusion Criteria:

* Patients harboring Glioblastoma
* Patient will undergo surgery

Exclusion Criteria:

* BMI \> 30
* Liver and Kidney Function so compromised that medication is prescribed
Food-Effect Bioavailability Study of FDC(Gemigliptin/Metformin HCl Sustained Release) 50/1000mg(25/500mg x 2tablets)

This study is designed to investigate the food-effects on FDC(gemigliptin/metformin HCl sustained release) 50/1000mg(25/500mg x 2tablets)


Eligibility Criteria:
Inclusion Criteria:

* Age between 20 to 45, healthy male subjects(at screening)
* BMI between 19.0 - 27.0
* FPG 70-125mg/dL glucose level(at screening)
* Subject who totally understand the progress of this clinical trials, make decision by his free will, and signed a consent form to follow the progress.

Exclusion Criteria:

* Subject who has past or present history of any diseases following below.(liver including hepatitis virus carrier, kidney, Neurology,immunology,pulmonary,endocrine,hematooncology,cardiology,mental disorder.)
* Subject who had GI tract disease or(ulcer, acute or chronic pancreatitis) surgery.(appendectomy, hernioplasty are not included)
* Subject who had drug hypersensitivity reaction.(Aspirin, antibiotics)
* Subject who already participated in other trials in 90 days
* Subject who had whole blood donation in 60 days, or component blood donation in 30 days or transfusion in 30 days currently.
* Smokers.(but, if the subject did'nt smoke in 3months, can participate the trial)
Molecular Mechanisms of Dutasteride and Dietary Interventions to Prevent Prostate Cancer and Reduce Its Progression

The purpose of this study is to determine whether marine omega-3 fatty acids and 5-alpha-reductase inhibitor are effective in the progression of prostate cancer for low-risk prostate cancer patients.

The study has a duration of 1 year for each participant. Subjects will be first assigned to a dietary or a dutasteride intervention that they will consume for the first 6 months. After 6 months, all men will have a combined intervention of dutasteride and diet to complete follow-up of 12 months. This will allow us to study interactive effects.

Dietary intervention consists on a high w-3 long-chain fatty acids diet without supplement and to reduce intake of saturated and trans fatty acids.

Prostatic biopsies will be taken at time of diagnosis and at 6 and 12 months after the beginning of the study. Blood will be drawn before each prostate biopsy session and urine will be collected before each prostate biopsy and after digital rectal examination.

Eligibility Criteria:
Inclusion Criteria:

* Low-risk prostatic neoplasms
* Candidate for active surveillance
* Informed consent

Exclusion Criteria:

* Current fish oil supplementation
* Current NSAID use
Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users

The proportion of elderly people is expected to increase greatly within the next couple of decades, resulting in a proportional increase in the need for hearing rehabilitation. However, studies suggest that as many as 40% of hearing aids are never or seldom used. Thus, a major challenge for audiological rehabilitation is facilitating the use of fitted hearing aids.

This study has four objectives; 1) to evaluate the effect of advanced notice of a follow-up appointment on hearing aid use, 2) to implement a specialized counselling program based on MI, 3) to identify barriers to hearing aid use, and 4) to objectively assess hearing aid use with datalogging technology.

Hearing impairment is one of the most common health issues among adults in Western countries. Socioeconomic status and level of family support are known to influence help-seeking among older hearing-impaired individuals. Although hearing loss can have significant adverse effects on an individual's quality of life, these effects have been found to be reversible through the use of hearing aids. Even short-time use has been found to improve the emotional and social experience of hearing impaired subjects. Unfortunately, of the approximately 200 000 people who have been provided with hearing aids in Norway, it is estimated that as many as 20-40% seldom or never use them. Lack of follow-up support and low motivation may explain why hearing impaired people do not use their hearing aids, but few research studies have addressed these issues.

The aim of this study is to evaluate two approaches for increasing hearing aid use, to obtain objective estimates of actual hearing aid use, to identify factors barriers to regular use and to study hearing aid use related to age and gender. The study will examine the extent to which follow-up appointments motivate use of hearing aids among people with hearing loss. A randomized controlled design will determine whether hearing aid users who are informed in advance of a follow-up appointment have a different pattern of hearing aid use than a control group that is not preinformed of the follow-up appointment. For decades, the use of hearing aids has been estimated using questionnaires. In the present study, hearing aid use will be objectively measured in hours pr.day using the hearing aid's datalogging. In addition, the study will develop, implement and evaluate a specialized counseling program for hearing aid users. Difficulties with and barriers to hearing aid use will be documented and analyzed.

Eligibility Criteria:
Inclusion Criteria:

* Age 65 + years old
* Subjective and objective need for hearing aids.

Exclusion Criteria:

* Not being able to communicate in Norwegian.
Use of Fish Skin Graft (FSG) to Improve Wound Healing and Expedite Discharge at a County Safety-net Hospital

The purpose of this study is to estimate the effect of FSG (Kerecis) on hospital length of stay among adult patients with surgical wounds of at least 40cm2 requiring surgical debridement


Eligibility Criteria:
Inclusion Criteria:

* Has wound greater than or equal to 40cm2 requiring surgical debridement
* Agreeable to follow up period of up to 1 year

Exclusion Criteria:

* Patients with wounds that do not require surgical debridement.
* Patients with a known allergy or other sensitivity to fish material
* Patients who are deemed unlikely to follow up (e.g., patients who live out of state).
* Patients in police custody/incarcerated.
* Patients unable to communicate in either Spanish or English.
Singapore Healthy Alternative Protein Evaluation Study

The overall aim of this randomized controlled trial is to investigate the effects of consuming a Plant-Based Meat alternative Diet (PBMD) compared to an Animal-Based Meat Diet (ABMD) on cardiometabolic health and protein homeostasis in Chinese men and women in Singapore. This will be achieved through the following specific objectives: (1) To evaluate the effects of dietary protein source on metabolic health and glycemic control(2) To evaluate the effects of dietary protein source on risk factors of cardiovascular diseases (3) To evaluate the effects of dietary protein source on protein homeostasis and metabolism.


Eligibility Criteria:
Inclusion Criteria:

1. Chinese males and females
2. Age \> 30 to \</= 70 years
3. Habitually consuming between 2 and 4 servings of protein-rich foods daily (\~20 g protein per serving)
4. Raised blood glucose (fasting glucose \>/= 5.4 and \</= 7.0 mmol/L) and/or (HbA1c \>/= 5.7 and \</= 6.4 %)
5. Fully vaccinated against COVID-19 (referred to as having completed a minimum of 2 doses Pfizer-BioNTech / Comirnaty / Moderna or 3 doses Sinovac-CoronaVac)
6. Ability to give an informed consent
7. Willing to adhere to study intervention procedures

Exclusion Criteria:

1. Obese: BMI (\>/= 27.5 kg/m2) and/or waist circumference (\>/= 102 cm for male; \>/= 88 cm for female)
2. Significant weight change (± 5 % body weight) during the past 3 months
3. Past bariatric surgery
4. Women who are pregnant, lactating or planning pregnancy
5. History or known present diagnosis of cardiovascular (i.e.hypertension (systolic/diastolic blood pressure: \>/= 140/90 mmHg), endocrine (i.e. type 1 and type 2 diabetes mellitus), gastrointestinal, hematological (G6PD and coagulation disorders), hepatic (hepatitis B and C), malignant, renal, respiratory, thyroid or other relevant disorders which may affect the outcomes of interested in consultation with the researchers involved
6. Prescribed and regularly taking western or traditional medicine which may affect the outcomes of interest in consultation with the researchers involved
7. History or present diagnosis of HIV and/or tuberculosis.
8. Drug abuse within the last 5 years
9. Taking dietary supplements which may affect study outcomes one month prior to their first visit (e.g. protein supplements, omega-3/6 supplements or other nutritional supplements such as Ensure, Anlene etc.)
10. Following any special diets which may interfere with intervention procedures (for medical, aesthetic or religious reasons)
11. Allergy to nuts, seeds, legumes (soy, pea), cereal (wheat gluten), beef, pork, chicken or any other ingredients present in foods provided for intervention
12. Excessive alcoholic beverage consumption \> 2 servings per day (1 serving is defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)
13. Smoking (cigarette, e-cigarette, cigar, pipe) or vaping
14. Exercising vigorously over the past 3 months
15. Staff of Prince September Pte. Ltd. (Pinduoduo Inc.) and/or Singapore Institute of Food and Biotechnology Innovation (SIFBI)
Determination of the Effect of Puzzle Use in Elderly Patients

The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and face-to-face interview techniques.

Aging is a process involving biological, physiological and psychological changes. With aging, deterioration in brain, behavior and cognitive functions is observed. In this process, physical and cognitive deficiencies and slow thinking can be seen. The independence of elderly individuals in meeting their self-care decreases. Over time, individuals become unable to meet their needs and this reduces the quality of life of individuals. With the developing technology, perioperative care techniques began to develop and the number of surgical procedures applied to elderly patients began to increase.One of the most important goals in the field of health today and in the future will be to increase the quality of life of individuals. It is becoming increasingly important to determine the effective factors to protect cognitive functions in elderly individuals.After surgical procedures, patients may experience memory loss and decrease in concentration. Symptoms indicating a decrease in cognitive functions were named as postoperative cognitive dysfunction. Compared to other individuals undergoing surgery, the rate of cognitive changes in the early period is higher in the elderly.Especially, elderly patients who underwent orthopedic surgery are thought to be a risky patient group for postoperative cognitive impairment.Solving jigsaw puzzles is a low-cost, motivating, visuospatial cognitive-challenging activity.This study will be conducted in order to determine the effect of this strain on the cognitive functions of the individual and to investigate the effect of focusing on completing the puzzle on post-operative recovery and quality of life, as it will focus the individual's perception on a certain point.

Eligibility Criteria:
Inclusion Criteria:

* 65 years and older,
* Having been hospitalized in the orthopedic service for at least three days after the operation,
* Having undergone orthopedic surgery,
* No hearing or vision problems,
* Able to communicate,
* No cognitive or psychiatric problems,
* At least primary school graduate,
* Patients who agreed to participate in the study

Exclusion Criteria:

* Using jigsaw puzzles regularly,
* Using drugs that affect memory and thinking

These drugs are:

1. Sedative and Hypnotic Drugs

   * Benzodiazepines
   * Barbiturates
   * Non-barbiturate
   * Other Sedative and Hypnotics (zolpidem, buspirone, hydroxyzine)
2. Anticonvulsant Drugs
3. Drugs Used in Parkinson's Treatment
4. Drugs Used in the Treatment of Psychiatric Diseases
5. Drugs with Narcotic Analgesic Effects
6. Anesthetic Drugs
7. Neuromuscular Blocking Drugs - Patients with cerebrovascular accident or head injury
Pilot Study of Riluzole for Drug-Refractory Irritability in Autism Spectrum Disorders

Determine if riluzole shows evidence of efficacy, safety, and tolerability targeting drug-refractory irritability (DRI) in persons with autism spectrum disorders (ASD).

A randomized, double blind, placebo-controlled, 12-week cross-over study (5-week treatment periods with 2-week washout) of adjunctive riluzole in 12 persons with ASD and DRI between the ages of 12 and 25 years.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 12 and \< 26 years.
* Weight greater than 50 kg.
* Diagnosis of ASD
* Drug-refractory irritability, as defined as screening ABC Irritability subscale (ABC-I) score of ≥18 AND 1) failure of clinically adequate treatment trials of both aripiprazole and risperidone or 2) failure of at least three previous clinically adequate drug trials targeting irritability (one trial must include aripiprazole or risperidone), as confirmed by caregiver reports and medical record review when available.
* Stable dosing of all concomitant psychotropic medications (including those targeting irritability) for four weeks prior to screening visit and during the study.
* Presence of parent/guardian willing to serve as informant for behavioral outcome measures and shipping control sample for Extracellular Signal-Related Kinase biomarker (ERK) assay.

Exclusion Criteria:

* Current use of more than two concomitant psychotropic drugs targeting irritability.
* Current use of valproic acid.
* Current use of drugs with known interaction with riluzole
* Current use of drugs with concomitant glutamatergic or glutamatergic- modulating action medications.
* For female subjects of child bearing potential, a positive serum pregnancy test.
* History of pancreatitis.
* Hemoglobin less than or equal to 8.0 gm/dL.
* Neutropenia with absolute neutrophil count less than or equal to 1.0 K/mcL.
* Problems with kidney functioning, as assessed by lab work
* Any major chronic medical or chronic respiratory illness considered to be uncontrolled by the Principal Investigator.
Chongqing Intracerebral Hemorrhage Study

The Chongqing intracerebral hemorrhage study is a multi-center, prospective, observational study led by professor Qi Li from Chongqing Medical University. Professor Peng Xie will be the senior consultant for the study. The Chongqing intracerebral hemorrhage study will focus on the epidemiology, natural history, pathogenesis, laboratory, radiological aspects, clinical outcomes and the effects of treatment in patients with intracerebral hemorrhage.

The clinical, laboratory, imaging, genetic and outcome data of patients diagnosed with acute intracerebral hemorrhage will be prospectively collected. The prognosis of patients with intracerebral hemorrhage will be assessed by using several outcome measure scales at different time points.

The Chongqing intracerebral hemorrhage study will try to address several key issues in ICH. The baseline clinical data including demographic, disease severity scores, prior drug history and relevant medical history, premorbid mRS scores will be prospectively recorded. The admission and follow-up imaging data of all registered patients will be saved as Dicom format for future use and review. The functional outcomes will be assessed and recorded by experienced neurologists.

Eligibility Criteria:
Inclusion Criteria:

* Age \>= 18 years
* Informed consent to participate in the study
* Patients diagnosed with CT-confirmed spontaneous Intracerebral Hemorrhage (ICH)
* Patients are willing to participate in the follow up assessment

Exclusion Criteria:

* Did not agree to participate in the study
* Secondary ICH to hemorrhagic infarction or tumor bleeding etc.
* Traumatic ICH
Effect of Acupuncture and Low Caloric Diet on Primary Hypothyroidism and Irregular Menstruation in Infertile Women

the goal of this randomize clinical trial is to compare in 60 infertile women with hypothyroidism. selected from national Nutritional institute out clinic. the main question it aims to answer is:

• There an effect of acupuncture and low caloric diet on primary hypothyroidism and irregular menstruation in infertile women.

all participants were received• thyroxine tablets (levothyroxine) • a low caloric diet regime.

researchers compared study group (30 infertile women with hypothyroidism) to see the effect of acupuncture sections on hypothyroidism.

Each woman was instructed carefully about the assessment and treatment procedures and a consent form has been signed by each woman before starting of this study,

* Each patient in the study group was instructed about the beneficial effect of the Acupuncture.
* Each woman in the study group assumed supine position for the points (DU20, GB20, ST9, LI4, RN6, RN4, SP9, ST36, SP6, KI3, LR2). and prone position for DU14, BL15, BL20, BL23, DU4 with uncovered treatment area, which was cleaned with alcohol and hair was removed.

Acupuncture was applied on a room temperature of 37. Fine sterile needles used with a size 0.25x25mm. They were inserted to various depths (2-5 cm) at acupoints points on the body according to site and fat deposition. 16 needles were used in the treatment.

Eligibility Criteria:
Inclusion Criteria:

* Sixty PCOS women will be evaluated for presence of hirsutism, acne, irregular menses. They will be diagnosed for presence of cysts by Ultrasonography apparatus.
* They will complain from primary hypothyroidism. Their thyroid-stimulating hormone (TSH) will be \>4.0mu/l and free tetraiodothyronine (FT4) will be \<0.8ng/dl.
* Their luteinizing hormone / follicle-stimulating hormone (LH/FSH) ratio will be \<1.
* Their age will range from 20-35 years old.
* Their body mass index (BMI) will be \> 25 kg/m2 and \< 39.9 kg/m2.

Exclusion Criteria:

* History of previous neurological disorders, previous thyroidectomy, and surgical removal of uterus.
* Presence of hemorrhage, carcinoma, metal implants and using of immune suppressant drugs.
* Presence of endometriosis, uterine fibroids, primary ovary insufficiency, fallopian tube damage or blockage, pelvic adhesion, autoimmune disorders, implantation failure, and infections.
Biomarkers of Homeopathy in Fibromyalgia

The purpose of this study is to evaluate the efficacy of individualized classical homeopathy in treatment of persons with fibromyalgia and to determine the usefulness of electroencephalographic and electrocardiographic measures to serve as markers of differences between active and placebo treatment.


Eligibility Criteria:
Inclusion criteria:

* ACR diagnosis of fibromyalgia;
* Willing to take daily active or placebo liquid remedy under double blind conditions for 6 months, involving daily succussion and dilution of source liquid from a stock bottle;
* Willingness/ability to comply with dietary and lifestyle restrictions, i.e., no coffee in any form, no comphor or menthol-containing products; no electric blankets, no strong aromatics, no routine vaccinations, no concomitant use of acupuncture, chiropractic, polarity therapy, psychic healing, or magnet therapy;
* No dental drilling, MRI scans unless emergent;
* Withhold food or drink 30 mins before/after therapy;
* Stable conventional care for 2 months prior to entry;
* Willing to undergo 3 diagnostic physical exams, and to permit videotaping of interview sessions;
* Willing to fill out questionnaires

Exclusion criteria:

* Steroid-dependent medical conditions;
* Chronic benzodiazepine or anticonvulsant use;
* Use of tricyclic antidepressants, antihypertensives, and other drugs that alter orthostasis;
* Pregnancy;
* History of seizure disorder or syncope;
* Life-threatening medical conditions;
* Current active asthma;
* History of anaphylactic shock;
* Insulin-dependent diabetes;
* Active suicidal ideation or psychosis.