cyrilzakka/clinical-trials huggingface dataset:
Dry Needling and Spinal Manipulation vs. Conventional PT for Lumbar Spinal Stenosis

The purpose of this research is to compare two different approaches for treating patients with lumbar spinal stenosis: electric dry needling and thrust manipulation versus impairment-based manual therapy, stretching, strengthening and electrothermal modalities. Physical therapists commonly use all of these techniques to treat lumbar spinal stenosis. This study is attempting to find out if one treatment strategy is more effective than the other.

Patients with lumbar spinal stenosis will be randomized to receive 1-2 treatment sessions per week for 6 weeks (up to 12 sessions total) of either: (1) electric dry needling and thrust manipulation or (2) impairment-based manual therapy, stretching, strengthening and electrothermal modalities

Eligibility Criteria:
Inclusion Criteria:

1. Adult over the age of 50 years old that is able to read, write and speak English
2. Symptoms of neurogenic claudication (pain in the buttock, thigh, or leg during ambulation that improves with rest) or radicular leg symptoms with associated neurological deficits on the physical examination for at least 12 weeks.
3. Confirmatory imaging (i.e. magnetic resonance imaging (MRI), computed tomography (CT), myelography, ultrasound or X-ray of either central or lateral (foraminal) lumbar spinal stenosis at one or more levels in the lumbar spine.

Exclusion Criteria:

1. Report of red flags to manual physical therapy to include: severe hypertension, infection, ankylosing spondylitis, neoplasm, uncontrolled diabetes, peripheral neuropathy, heart disease, stroke, chronic, ischemia, edema, severe varicosities, tumor, metabolic disease, prolonged steroid use, fracture, RA, osteoporosis, severe vascular disease, malignancy, etc.
2. Severe vascular, pulmonary, or coronary artery disease limiting participation in exercise, to include a walking program (including presence of absolute contraindications to submaximal exercise testing)
3. Severe degenerative stenosis with intractable pain and progressive neurological dysfunction
4. Lumbar spinal stenosis not caused by degeneration
5. Radiographic evidence of instability, degenerative spondylolisthesis, fracture or scoliosis of more than 15°
6. Lumbar herniated disc diagnosis during the last 12 months.
7. Previous lumbar surgery for lumbar spinal stenosis or instability (i.e. previous lumbar fusion, lumbar microdiscectomy, lumbar foraminotomy, lumbar laminectomy, etc.)
8. Psychiatric disorder or cognitively impaired.
9. Pregnancy
Sleep and Stent Study: a Multicentre, Prospective Study

Elucidating the effects of obstructive sleep apnea (OSA) on cardiovascular outcomes is crucial in risk assessments and therapeutic recommendations for affected individuals. The Sleep and Stent Study is a multi-center observational study investigating the relationships between OSA and cardiovascular outcomes in patients treated with percutaneous coronary intervention (PCI).

Preliminary data suggest that OSA may lead to adverse cardiovascular outcomes after PCI. However, existing data were generated from small-scale, single-center studies. Therefore, in the Sleep and Stent Study, the investigators aim to conduct a large-scale multi-national cohort study to determine the association between OSA and the incidence of adverse cardiovascular outcomes over a long-term follow-up period. The investigators hypothesize that OSA is an independent risk factor for the development of major adverse cardiovascular and cerebrovascular events (MACCEs) in coronary artery disease patients treated with PCI. Results from the Sleep and Stent Study will advance the fundamental understanding of the burden and prognostic implications of OSA in patients undergoing PCI for coronary artery disease.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years old and \< 80 years old
* Successful PCI to at least one of the epicardial coronary arteries

Exclusion Criteria:

* Known OSA on CPAP treatment
* Intubation for mechanical ventilation
* Intra-aortic balloon pump or other hemodynamic support device
* Sedation or other muscle relaxant given before overnight sleep study
* Perceived high risk of malignant ventricular arrhythmia
* Cardiogenic shock with systolic blood pressure \<90 mmHg
* Clinical heart failure requiring oxygen supplementation
* Pregnancy
* History of malignancy (except non-melanoma skin cancer, cervical in-situ carcinoma, breast ductal carcinoma in situ or stage 1 prostate carcinoma)
Influencing Factors on Training Efficacy in Healthy Adults

The purpose of this study is to investigate the effects of carbohydrate intake on training efficacy and health parameters of an endurance training program in healthy adults.

Carbohydrate availability in endurance exercise seems to attenuate exercise-induced perturbations of cellular homeostasis and consequently diminishes the stimulus for training adaptation. Therefore, a negative relationship with exercise efficacy seems plausible. However, experimental evidence is rare and far from conclusive. Therefore, the present study aims to test the influence of carbohydrate intake on the efficacy of a typical preventive training program.

Eligibility Criteria:
Inclusion Criteria:

* no diseases
* nonsmoker
* BMI 25-30 kg/m²
* blood pressure \<160/100 mm/Hg
* unmedicated
* untrained status
* V̇O2max \< 50 mL/kg/min
Estimation of Perioperative Atelectasis

This study will compare an oxygenation test based on arterial blood gas analysis with computed tomography for estimating the extent of atelectasis.

Computed tomography of the lungs is the gold standard for investigating the extent of atelectasis, which is common in the perioperative setting. Atelectasis increase the risk of postoperative pulmonary complications and result in pulmonary shunt, which is one of the two major causes of impaired oxygenation. The other cause is admixture of venous blood from poorly ventilated regions of the lungs. The investigators have developed an oxygenation test utilizing arterial blood gas analysis at different inspired fractions of oxygen, which may be used to distinguish between these two causes. This observational study aims to establish the agreement between computed tomography and the oxygenation test for estimating the extent of atelectasis.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiology (ASA) class I-II.
* Non-abdominal day case surgery under general anesthesia.
* Patients enrolled in study registered in ClinicalTrials with NCT ID.

Exclusion Criteria:

* Arterial oxygen saturation (SpO2) \<90 % with 40% Venturi mask.
* Unstable postoperative condition needing immediate treatment.
Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia

The purpose of this study is verify the safety and efficacy of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Spinocerebellar Ataxia, and in addition, explore the possible mechanisms of UC-MSC therapy in Spinocerebellar Ataxia.

This is a random, open label, and parallel controled experiment. 45 patients are selected and sign consent forms, then divided into three groups. Doctors collect the basic information of patient (including age,height, mental condition, vital sign, history of disease, pharmaco-history, genotype test, and so on.) All patients receive laboratory and image examination as baseline. Then, they will give cell treatment based on the clinical protocol. Doctors have follow-up visit on 1, 2, 3, 6, and 12 months after treatment, and do efficacy evaluation.

Eligibility Criteria:
Inclusion Criteria:

* Clinical and genomic test diagnoses as spinocerebellar ataxias (SCA) (include SCA 1, SCA 2, SCA 3, SCA 6), SARA (Scale for Assessment and Rating of Ataxia) score is 2-5, can complete 8-meter walking test（8MW）
* Do not receive stem cells treatment in 6 months
* Participants sign the consent form based on the experiment process and statement

Exclusion Criteria:

* Cardiac, renal, hepatic insufficiency; total bilirubin is 1.5 times higher than normal value, aspartate transaminase（AST）or alanine aminotransferase（ALT）is 2.5 times higher than normal value
* Hemogram: total white blood cells \<3.0 \* 10\^9 cells/L, blood platelet \<75 \* 10\^9/L, hemoglobin \<100g/L
* pneumonia, or severe infection
* With severe allergic history
* Brain organic disorder, like brain tumor
* Serum with HIV, syphilis antibody positive
* Severe mental disease, cognitive disorder patients
* Other severe system or organ organic disease
* Pregnant, breast feeding, or planning pregnant women
* Participate other clinical experiments in 3 months
* With some other conditions that doctor propose not to participate
Placebo-Controlled Study of ONO-2333Ms in Patients With Recurrent Major Depressive Disorder

The purpose of this study is to evaluate the safety and efficacy of ONO-2333Ms in patients with Recurrent Major Depressive Disorder


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with recurrent major depressive disorder

Exclusion Criteria:

* Patients with treatment resistance for depression
* History of alcohol abuse/dependence, substance abuse/dependence within 6 months
* Has clinically significant unstable medical condition
* Has significant risk of suicide
Evaluation of Total Disability (I.T.T.) in Victims of Psychotraumatism.

The increase in psychological violence in our society, but also and above all the search for the best possible reparation for this violence, leads increasingly to questioning the evaluation of psychotraumatisms. In practice, there is no consensus as to the method of assessing psychological repercussions and determining ITI. This topic concerns any physician

The increase in psychological violence in our society (psychological repercussions of physical violence, situations of harassment, psychotraumatism linked to the series of attacks suffered in France), but also and above all, the search for the best possible reparation for this violence The victims and the society), leads increasingly to question the evaluation of psychotraumatisms. In practice, there is no consensus as to the method of assessing psychological repercussions and determining ITI. This topic concerns any physician involved in the care of victims, whether he is a doctor in primary care or in specialized care.

Eligibility Criteria:
Inclusion criteria:

* Patients over 18 years of age taken in charge at the Médico-Judiciaire Unit of the CHU Montpellier following a physical and / or psychological traumatism. - - Starting up between 01.01.2016 and 31.12.2016.
* Patients who have undergone a double assessment (medical and psychological).

Exclusion criteria:

* Patients under the age of 18 years.
* Consultation within the framework of a takeover started before 01.01.2016.
* Absence of double medical and psychological evaluation.
A Clinical Study on the Feasibility and Safety of Abdominal Endoscopic Single-port Surgery System to Assist Gynecological Day Surgery

In this study, a prospective study is used to select patients who will undergo intra-abdominal endoscopic single-port surgery system for benign gynecological diseases from February 2025 to December 2026 in the Second Affiliated Hospital of Wenzhou Medical University, including hysterectomy, myomectomy, ovarian cyst removal and adnexectomy. The study will perform statistical analysis to evaluate the feasibility and the main factors affecting the safety of intra-abdominal endoscopic single-port surgery system(SR-ENS-600) used in gynecological day surgery.


Eligibility Criteria:
Inclusion Criteria:

1. Women aged 18 to 75 years old, with a body mass index (BMI) of no more than 32 kg/m2;
2. Conscious, no history of mental illness, accompanied by an adult during the perioperative period;
3. Educate the subjects, who are willing to undergo day surgery, understand and accept the surgical method and anesthesia method;
4. Subjects and families understand perioperative care and are willing and able to complete post-discharge care;
5. Elective surgery, no serious complications affecting the operation and prognosis, aCCI age adjusted comorbidity index 0 points;
6. According to the adhesion risk scoring system of European Anti-Adhesions in Gynaecology Expert Panel (ANGEL), the adhesion risk was divided into three levels: high, medium and low. Subjects with low risk (0 to 12 points) and abdominal wall scarring and pelvic cavity B-ultrasonography do not indicate obvious pelvic cavity adhesion wiil be included.

Exclusion Criteria:

1. Moderate and high-risk patients will be excluded based on ANGEL adhesion risk scoring system;
2. Subjects with hemorrhagic rupture of ectopic pregnancy and unstable vital signs;
3. Genital tract infection or in the acute phase of systemic infection;
4. Subjects on long-term anticoagulant therapy or with coagulation dysfunction;
5. Subjects have severe heart and lung disease, liver and kidney dysfunction, and cannot tolerate anesthesia;
6. A history of abdominal or diaphragmatic hernia, abnormal umbilical cord development, or umbilical surgery;
7. Not willing to undergo endoscopic surgery;
8. Participated in other drug and device clinical trials within 3 months before surgery.
Acetaminophen's Efficacy For Post-operative Pain

The purpose of this study is to compare IV acetaminophen to oral acetaminophen for pain control in children undergoing tonsillectomy with or without adenoidectomy.

Tonsillectomy with or without adenoidectomy is a common surgical procedure in children and adolescents. Usually performed for recurrent tonsillitis or symptoms of airway obstruction, the procedure can result in significant post-operative pain. Common analgesic techniques include the use of oral acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen by mouth (PO) or ketorolac intravenous (IV), and narcotics. Acetaminophen has been shown to be effective in reducing pain and post-operative opioid requirements. Its administration can be oral, rectal, or intravenous. NSAIDs, though effective for pain control, have been shown to increase bleeding risk and disrupt hemostasis. Narcotics are effective for pain control but increase the risk of nausea and vomiting. They also have the potential to cause respiratory depression.

IV acetaminophen (OFIRMEV) is indicated for management of mild to moderate pain, and as an adjunct to opioids for severe pain. Several studies have examined the efficacy of IV acetaminophen vs placebo and/or active controls (meperidine, rectal acetaminophen (PR), tramadol). IV acetaminophen has been shown to be superior to placebo for pain control. Though there is data regarding peak plasma and Cerebral Spinal Fluid (CSF) concentration of acetaminophen when given by different routes (PO vs IV vs PR), there is no data comparing the efficacy of oral vs IV administration for pain control post-tonsillectomy in children.

Eligibility Criteria:
Inclusion Criteria:

* Children 5-13 years of age
* Surgical procedure: tonsillectomy with or without adenoidectomy
* American Society of Anesthesiologists physical status classification 1 and 2 (patients that have either no systemic illness or mild systemic disease that is well-controlled, e.g. mild asthma)

Exclusion Criteria:

* Known allergy to study medication(s)
* Known genetic abnormality
* Known hepatitis
* Children with other physical, mental or medical conditions which, in the opinion of the PI, make study participation inadvisable or impairs pain assessment
* Children who have taken any analgesic within 24 hours prior to surgery
* Enrollment in concurrent research study
* Pregnant patients\*
* Students/trainees/staff\*
* Mentally disabled/cognitively impaired\*
Research Into the Quality of the Dying Phase

The aim of this study is to get insight in the quality of life at the end of life and quality of dying for patients died at the hospital in the department Groningen (the Netherlands).

The primary endpoint is the quality of life at the end of life and the secondary endpoint is the quality of dying. Both according a numerical rating scale.

An explorative analysis will be done for differences for the hospitals in Groningen, effect of using the Liverpool care Pathway for the dying, effect of using consultation by the palliative consultation team, effect of using the Hospice@UMCG intervention, correlation with the quality of life at the end of life and quality of dying according to nurses and doctors.

Three hospitals in the department Groningen (the Netherlands) will participate in this study. When a patient died in one of these hospitals (except the emergency department, child ward and intensive care unit) the bereaved relatives will get an information letter. After about 12 weeks a questionnaire will be sent to the bereaved relative. This questionnaire is developed to evaluate the end of life care at the hospital.

Shortly after the patient died at the hospital, also the nurse and doctor of this patient are requested to fill out a questionnaire.

The questionnaire for the bereaved relatives consists of items, divided in groups: a general part, followed by questions of the last days of life, existing symptoms (physical, psychological, existential and social), the care and treatment and the loss.

The questionnaire for the nurses exists of similar items. Special attention for recognizing the impending dying and problems, care and therapy at the end of life.

In all questionnaires there are also 2 main questions: What is your opinion of the quality of life during the last days of life and What is your opinion of the quality of dying.

In the three hospitals the end of life care is managed at somehow different ways: the use of the Liverpool care Pathway of the dying, the hospice@UMCG intervention and consultation by the palliative team of the hospital.

Eligibility Criteria:
Inclusion Criteria:

* patients dying in the hospital

Exclusion Criteria:

* patients dying at the child ward, emergency dept. and intensive care dept.
Clinical Performance of Bulk Fill Composite With Activa Bioactive Liner

electromyographic activity as well as clinical performance of bulk-Fill composite resins with Activa Bioactive Liner


Eligibility Criteria:
Inclusion Criteria:

* Patients between the ages of 18-40 years and cooperative patient.
* Good oral hygiene.
* Normal occlusal relation with normal dentition.

Exclusion Criteria:

* Patient with severe medical problems.
* Tenderness with percussion or pre-operative pulpal pain.
* Mobile tooth and tooth with gingival recession.
* Pregnant or lactating females.
* Cracked teeth or teeth with deep periodontal pockets.
* Tooth with previous restoration.
* Allergy to resin materials.
* Defective restorations adjacent or opposing to tooth.
* Patient with bruxism
Learn to Quit-HIV Pilot Study

The study team will conduct a feasibility, acceptability, and preliminary efficacy trial comparing Learn to Quit-HIV (n=30) to an app based on U.S. Clinical Practice Guidelines only (NCI QuitGuide; n=30) among HIV-positive smokers. Both apps will be integrated with NRT and ongoing HIV clinical care.


Eligibility Criteria:
Inclusion Criteria:

* HIV-positive
* Currently engaged with an HIV care provider
* Self-report smoking 5 cigarettes or more per day during the past 30 days
* Age 18 years or older
* Current interest in quitting smoking
* Currently own a functioning Android or Apple smartphone

Exclusion Criteria:

* No desire to quit smoking
* Inability to attend study sessions
* Inability to provide informed consent
* Any medical condition or concomitant medication that could compromise subject safety or treatment, as determined by the Principal Investigators and/or Study Physician
* Presence of contraindications for nicotine patch
* Previous allergic reaction or hypersensitivity to nicotine patch (lifetime)
* Current use of nicotine replacement therapy or other smoking cessation treatment (e.g., bupropion, varenicline)
* Pregnant, planning to become pregnant, nursing, or becoming pregnant during the study
* Current untreated and unstable diagnosis of alcohol/substance abuse or dependence (eligible if past abuse/dependence and if receiving treatment and stable for \>30 days)
Mycophenolate Mofetil in Membranous Nephropathy and Focal Segmental

This is a prospective randomized open-label pilot study to investigate the effect of mycophenolate mofetil treatment in patients with abnormal urine protein excretion due to membranous nephropathy (MN) or focal segmental glomerulosclerosis (FSGS). The change in urine protein excretion will be the primary outcome studied. The treatment regimen comprising prednisolone and mycophenolate mofetil will be compared with prednisolone and chlorambucil in MN, and compared with prednisolone in FSGS. The study duration will be 12 months for each patient.


Eligibility Criteria:
Inclusion Criteria:

* abnormal urine protein excretion and biopsy-proven idiopathic membranous nephropathy or focal segmental glomerulosclerosis
An Epidemiological Registry Study to Evaluate Clinical Practice Treatment in Patients With Bipolar Disorder

The aim of this study is to describe the treatment pattern and patient characteristics in real life setting in patients with Bipolar disorder treated with Seroquel XR and/or Seroquel IR in Sweden.

An epidemiological registry study to evaluate clinical practice treatment in patients with Bipolar Disorder treated with quetiapine XR and/or quetiapine IR

Eligibility Criteria:
Inclusion Criteria:

* Patients with a diagnosis of BD.

Exclusion Criteria:

* Patients with a diagnosis of any schizophrenia spectrum disorder after the diagnosis of bipolar disorder.
Impact of Nimodipine on Sublingual Microcirculation in Patients With Hemorrhage - a Prospective Monocentric Observational Study

Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.

SAH group - in patients with SAH and documented vasospasms by digital subtraction angiography (DSA) of trans-cranial doppler imaging (TCD) of arteria cerebri media nimodipine is indicated because it is proven to improve the clinical outcome. The disfunction of cerebral microcirculation in rats with SAH has been documented \[1-6\]. Changes in sublingual microcirculation in patients with SAH with documented vasospasms with nimodipine has not been described.

Eligibility Criteria:
Inclusion Criteria:

* adulthood
* ICU admission
* diagnosis of non-traumatic subarachnoid hemorrhage

Exclusion Criteria:

* inherited coagulation disorder
* rheumatic disease
* microangiopathy
* patient of representative refusal
Pharmacokinetic Study of SH-1028 Tablets in Healthy Subjects Under Fasting and Fed Conditions

To evaluate the food-effect of SH-1028 Tablets by pharmacokinetics in healthy subjects under fasting and fed conditions.

By analyzing safety and pharmacokinetics of SH-1028 Tablets in healthy subjects, pharmacokinetic characteristic will be evaluated mainly under fasting and fed conditions.Safety including AE/SAE is also a significant secondary objective.

Eligibility Criteria:
Inclusion Criteria:

1. Healthy Subject with acceptable laboratory results.
2. BMI between 19 and 26; Weight between 50 and 80 kg
3. Not allowed to smoke or drink during the trial.
4. Subject should be willing to contracept during the study and until 6 months after completion of study.

Exclusion Criteria:

1. Any clinically relevant abnormalities in physical examination, vital signs, hematology, clinical chemistry, urinalysis or ECG at baseline in the opinion of the Investigator.
2. History of severe allergy/hypersensitivity or or ongoing allergy/hypersensitivity
3. Addicted to smoking and drinking.
4. Hemorrhage over 200mL in 3 months before the trial.
5. Other conditions not suitable for trial, by judgement of investigator.