cyrilzakka/clinical-trials huggingface dataset:
Investigation of the Impact of Burn Injury on Parents

Burn injuries are related to longer hospital stay. Patients who have a burned child are affected prolonged hospitalization. Social life and quality of life are affected by burn injuries. Therefore, the aim of this study is to investigate the effects of burn injury on parents.

Pediatric burn injuries is commonly seen. Burn injuries are extended from minor injuries to severe injuries. The severity of burn injury may affect burn related complications such as scar tissue and duration of hospitalization. This process extremely affect parents. Although parents are part of this prolonged treatments process, there is no study that evaluated of the impact of burn injury on parents. Therefore, the aim of this study is to investigate the effects of burn injury on parents.

Eligibility Criteria:
Inclusion Criteria:

* Parents who have a burned child
* Parents who have a volunteer

Exclusion Criteria:

* Parents who have no confirm to participate this study
Study of Cerebral Vascular Reserve Using Pharmacological Testing With Acetazolamide: A Non-Inferiority Study of PET Method Compared to Conventional Reference Scintigraphy

This study compares two methods for assessing brain blood flow. PET scan will be use with a drug called Acetazolamide and compare its effectiveness to the standard scintigraphy method. The goal is to see if the PET scan is just as good as the traditional method in measuring how well the brain's blood vessels respond to the drug.


Eligibility Criteria:
Inclusion Criteria:

* Chronic stenosing cerebral vascular pathology (stenosis \> 70% on Doppler examination or angiography).
* Patient aged over 18 years.
* Patient who has voluntarily agreed to participate in the study and has signed the written informed consent.
* Patient affiliated with a social security system.

Exclusion Criteria:

* Patient with stenosis less than 70% on Doppler examination or angiography.
* Patient with a contraindication to 18F-FDG PET examinations: severe claustrophobia, poorly controlled diabetes during 18F-FDG PET examinations (fasting capillary blood glucose ≥ 11 mmol/L).
* Patient with a contraindication to scintigraphy.
* Patient with an allergy to sulfonamides (Acetazolamide DIAMOX®).
* Patient enrolled in another clinical study with a specified exclusion period.
* Minor patient.
* Patient unable to give informed consent.
* Vulnerable individuals
Study of Hierarchy of Afferents in Postural Control of Children With Dyslexia

The purpose is to determine the hierarchy of sensory afferents according to different forms of dyslexia in children.

The secondary purpose is to determine sensitive and sufficiently specific posturographic indexes for standard diagnosis of different types of dyslexia.

This study evaluates the postural control and the importance of proprioception, evaluated by static and dynamic posturography, in dyslexic children compared to age-matched control group. Posturographic data and a questionnaire for motion sickness disorder are used as proprioceptive disorder index. This study aims to better characterize the dyslexic population with techniques targeting central integration of sensory proprioceptive afferents. The purpose of this study is not to search for a postural deficiency syndrome, but to study proprioception with posturography, with quantitative and normalized data of analyzed population. Moreover, these data could allow an objective evaluation of reeducation with quantifiable and reproducible parameters in order to judge its effectiveness. The demonstration of the existence of a relationship between proprioceptive disorders and dyslexia will imply a specific reeducation care of patients. A study using validated and standard indexes is necessary. The presence of postural disorders and a major susceptibility to motion sickness could contribute to distinguish different forms of dyslexia and thus be complementary to actual medical, orthophonic and neuropsychological criteria. In this evaluation, it is important to distinguish between visuo-attentional dyslexia from phonological dyslexia involving distinct anatomo-functional neuronal circuits.

Eligibility Criteria:
Inclusion Criteria:

All:

* Parents of child and child having given informed consent
* Affiliation to social security
* Preliminary medical examination

Dyslexia groups:

- Diagnosed and characterized dyslexia

Exclusion Criteria:

All:

* Medical pathology, especially neurological, ophthalmological, otorhinolaryngological or orthopedic, modifying postural control, detected with medical examination
* Insufficient compliance of child especially due to fatigue
* Contact allergy to cutaneous electrodes
* Current treatments: psychotropic drugs and all drugs diminishing awareness or causing dizziness or equilibrium disorders

Control group:

- Patient having a dyslexia or oral or written language disorder
MK0431/ONO-5435 Phase III Clinical Trial -Add-on to Voglibose Study for Patients With Type 2 Diabetes Mellitus (MK0431-104)

The phase III clinical trial examines the efficacy, safety, and tolerability of the addition of MK0431/ONO-5435 to Japanese patients with type 2 diabetes mellitus (T2DM) who have inadequate glycemic control on diet/exercise therapy and voglibose monotherapy


Eligibility Criteria:
Inclusion Criteria:

* Japanese Patients With Type 2 Diabetes Mellitus, Who Have Inadequate Glycemic Control On Diet/Exercise Therapy And Voglibose Monotherapy

Exclusion Criteria:

* Patients Have A History Of Type 1 Diabetes Mellitus
Fecal Microbiota Transplantation for Eradication of CRE

Antibiotic resistance has emerged world wide and is of major concern. Multi-drug resistant (MDR) bacteria is widely spread and is now a major factor in morbidity and mortality in health-care settings. Among MDRs, carbapenem-resistant Enterobacteriaceae (CRE) are of special concern, receiving the highest classification of "urgent threat level" in the US President Report. Consistent mortality rates of 40-50% are observed among inpatients with infections caused by CRE in hospitals worldwide, related mainly to unavailable, delayed or ineffective antibiotic treatment options.

The extremely high mortality rates of patients with CRE infections have driven efforts to prevent the acquisition and spread of these bacteria in hospitals. These include screening for carriage, contact isolation of carriers, cohorting, dedicated healthcare staff and other infection control measures. These strategies have been proven as effective but are cumbersome and expensive. In most locations these strategies failed to completely eradicate CRE endemicity.

CRE decolonization (eradication of colonization) might offer a double benefit - reducing the risk for the individual carrier to develop an infection due to the resistant strain (by that, potentially lowering the mortality risk) and preventing the bacteria from spreading to other patients, exposing them to the same hazard.

Fecal microbiota transplantation (FMT), in which fecal material enriched with commensal microorganisms is transferred from a healthy donor, have proven efficacy in the treatment of recurrent Clostridium difficile infection (CDI) in multiple trails. Major adverse events that has been reported so far are mostly related to the route of administration (aspiration during nasogastric tube administration/colonoscopy). Other adverse events include mostly GI related symptoms (diarrhea, nausea, belching) and are self limited and resolve in few hours. FMT seems to be safe and effective both in immunocompetent and immunocompromised patients.

The high efficacy of FMT in the treatment of a multi-drug resistant pathogen such as Clostridium difficile, suggest that it might be an efficient tool for other MDR pathogens (e.g. CRE).

The authors aim to assess the effects of FMT on colonization and clinical infections with CRE. The potential of FMT to restore the gut microbiome and compete with residual resistant strains offer a novel way to fight the current MDR epidemic.

The authors will apply FMT on a cohort of CRE carriers in a single center in Israel. FMT will be given by capsules for 2 consecutive days followed by rectal sampling at predefined timepoint in the following 6 months.


Eligibility Criteria:
Inclusion Criteria:

* Adult inpatients ≥18 years positive for CRE of any strain and resistance mechanism in rectal surveillance stool samples, with or without CRE clinical samples. A positive rectal swab within one week before randomization will be mandatory.

Exclusion Criteria:

* Pregnant women
* Patients with severe neutropenia (\<100/µl)
* Surgical patients with perfurated viscous
Osteopathic Treatment to Alcohol Withdrawal Syndrome

The alcohol withdrawal syndrome has a hierarchical symptomatology depending on the severity (minor, moderate or severe). These signs express a state of psychic, behavioral and physical deprivation.

The management of withdrawal syndrome involves the establishment of pharmacological and psychosocial interventions.

Osteopathy is an exclusively manual practice whose purpose is to overcome the dysfunction of mobility of tissues of the human body. It can be used as a complementary treatment when a specific support is put in place. The purpose of this study is to examine the effectiveness of osteopathy in reducing alcohol withdrawal symptoms in adult patients.

The use of osteopathic techniques for facial equilibration decreases the severity of withdrawal symptoms experienced by patients hospitalized in a weekday hospital.

Eligibility Criteria:
Inclusion Criteria :

* Age\> 18 years
* Patient hospitalized for a programmed alcohol withdrawal
* Patient not abstinent with alcohol before hospitalization
* Signed informed consent

Exclusion Criteria :

* Minor patient
* Patient with an addiction other than alcohol (except tobacco and benzodiazepines)
* Previous participation in the OSTEOOL study
Dorsal Finger Reconstruction

objective of this study is To compare reversed cross finger flap with reversed island homo-digital flap in distal dorsal finger defect reconstruction regarding reliability \& functional and aesthetic outcomes .

comparative study that will be conducted at Plastic surgery department, Sohag university hospital on 30 patients .The population of the study will be patients with distal dorsal digital defects. We will divide the cases into two equal groups: the first are operated with reversed cross-finger flap and the second are operated with reversed island homo-digital flap.


Eligibility Criteria:
Inclusion Criteria:

* patients with dorsal digital defect distal to distal interphalangeal joint (DIP) joint
* defect size ranged from 1 to 2 cm in width and 1-3 cm in length

Exclusion Criteria:

* chronic heavy smokers,
* traumatic injury to the donor site and perforator .
Goodwill of Central Texas: Fatherhood Works Healthy Marriage and Responsible Fatherhood Program Evaluation

The key goal of this descriptive evaluation is to assess the extent to which participation in the Fatherhood Works Program is positively associated with improved attitudes and behaviors among fathers and father figures in Central Texas. Research questions will focus on whether attitudes and behaviors related to parenting, co-parenting, and employment change after participation in primary program services.

This evaluation seeks to understand the positive and/or negative impacts of an evidence-based core curriculum, Nurturing Fathers (NF), in combination with other workshops and case management services. All participants will receive a range of support services tailored to individuals' needs related to financial planning, career counseling, job search assistance, and occupational skills training. The program facilitator will offer the NF curriculum in both virtual and in-person formats. The evaluation will seek to determine to what extent participation in a program that uses Nurturing Fathers curriculum, in combination with other workshop programming, is associated with changes in parenting and employment attitudes as well as parenting and co-parenting behaviors.

Eligibility Criteria:
Inclusion Criteria:

* Father figure
* Child up to 24 years of age
* Resides in Central Texas
* Adult (age 18 and older)

Exclusion Criteria:

* Minor (under the age of 18)
* Not a father/father figure
* Resides outside of Central Texas
* Child is older than 24 years of age
Prevention of HEMOrhagic Risk in Upper MYOmeCTomy by Use of Misoprostol.

In France, uterine fibroids or leiomyomas are the most common benign tumour in women of childbearing age.

In 30% of cases, fibroids are symptomatic (menorrhagia, anaemia, pain), in which case surgical management is indicated. This is known as myomectomy, and can be performed by hysteroscopy, laparoscopy (laparoscopy) or laparotomy, depending on the number, size and position of the fibroids.

Intraoperative bleeding is the main surgical difficulty. For this reason, a number of studies have focused on ways of minimizing the risk of bleeding.

A good surgical indication, prevention of anaemia (iron deficiency) and transient occlusion of the uterine arteries during surgery help to reduce this risk. There are also drugs available to reduce intraoperative bleeding, but few studies have been carried out to assess their real effectiveness. One such product is Misoprostol, commonly used in gynecology. Its muscle-contracting properties suggest that it could have a beneficial effect on bleeding during surgery. What's more, this treatment has been used for many years and is reputed to be very well tolerated. The most frequent side effects are digestive, with a risk of abdominal pain in the form of cramps, nausea or vomiting.

The investigators therefore decided to set up the HEMOMYOC study to demonstrate a significant reduction in bleeding during laparotomy or laparoscopic myomectomy after taking oral misoprostol in combination with transient occlusion of the uterine arteries, compared with placebo. It would seem that the ease of use and good tolerance of misoprostol, in combination with transient occlusion of the uterine arteries, could be of real benefit in preventing intraoperative morbidity in myomectomies, whatever the surgical approach. To date, no studies have been carried out in this area.


Eligibility Criteria:
Inclusion Criteria:

* Patient aged 18 to 43
* Symptomatic myomas (bleeding, pain or infertility)
* Indication for laparoscopic myomectomy Fibroma ≤ 10cm or number ≤ to 4 fibroids
* Indication for myomectomy by laparotomy Fibroma \> 10cm, Number \> to 4 fibroids
* OTAU possible intraoperatively (Clip on uterine artery and tourniquet placement)
* Speak and understand French
* Affiliated with a social security scheme.

Exclusion Criteria:

* Previous abdominal surgery (excluding appendectomy) or myomectomy (excluding hysteroscopic myomectomy)
* Allergy to misoprostol and lactose
* Patients with hypersensitivity to misoprostol and/or other prostaglandins or to any of the product's excipients.
* Patients taking aspirin or anti-coagulants
* Patients with haemostasis disorders
* Malnourished patients
* Patients with hepatic or renal insufficiency
* Pregnancy, suspected ectopic pregnancy and breast-feeding women.
* Minors
* Guardianship, curatorship, deprived of liberty, safeguard of justice
Parenting Intervention for Pediatric Obesity

The purpose of this study is to see if educational videos about how to help children develop healthy behaviors, paired with treatment in a pediatric obesity clinic, can increase caregiver confidence and improve child behaviors and weight. Caregivers of children between the ages of 4 and 11 years old who are new patients to a pediatric obesity clinic will be invited to take part in the study. All families will receive the standard treatment provided in the pediatric obesity clinic. Half of the caregivers will be assigned to also watch a few educational videos every month for 3 months in between clinic visits.


Eligibility Criteria:
Inclusion Criteria:

* Legal guardian of a new patient to the Nemours pediatric obesity clinic
* Child with body mass index (BMI) greater than the 95th percentile for age and sex
* Child 4-11 years of age

Exclusion Criteria:

* Not proficient in English or Spanish
* Not able to access the internet on any type of device
* Child has a genetic syndrome or primary endocrine disorder associated with obesity
* Child is taking a medication known to impact weight
Characterization of Independant Task Neural Correlates of Different Levels of Mental Workload

The goal is to identify neuro-physiological signatures at several levels of mental workload during the realisation of tasks, performed by all the subjects.

In parallel, there will be a methodological work consisting to develop the classification algorithms, predictives of these levels of mental workload in real time, in purpose to implement a passive brain-machine interface in the best interest of operators that accomplish complex tasks.

Mesures of electro-physiological activity will be recorded in order to approve states of charge in addition to behavioral performances.


Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent
* Medical examination made before search involvement
* Between 20 and 40 years
* Right-handed
* Minimum study level : Baccalauréat
* Membership of the French social security
* Normal vision and hearing (or corrected to normal)

Exclusion Criteria:

* Sujects included in a clinical or therapeutic trial in progress
* Vision or hearing essential disorder
* Neurological or neuropsychiatric pathology current or gone
* Drug treatment which could alter brain activity (antidepressants, benzodiazepine, lithium etc)
* Pregnant, parturient or breast feeding women
* All other category of protected people
Integrating Community Health Workers to Improve Diabetes Prevention

Cluster randomized trial to test the impact of peer health coaches on prediabetic patients. This study will test a scalable model of peer health coaching to address the millions of patients at risk for Diabetes Mellitus, using low cost, culturally congruent personnel to promote prevention of Diabetes Mellitus in patient-centered medical home (PCMH) practice.

This population based trial aims to understand the impact of peer health interventions on panels of patients in a real clinic environment

Investigators will conduct a cluster-randomized trial to test the impact of peer health coaches on prediabetic patients cared for by patient-centered medical home model (PCMH) teams to:

1. Reduce the incidence of type 2 DM in pre-diabetic, PCMH patients;
2. Promote weight loss among pre-diabetic patients;
3. Increase patient activation levels, a measureable construct of engagement, efficacy, skills, and confidence in managing one's health, among pre-DM patients, resulting in:

   1. Improved secondary clinical outcomes: better glycemic and blood pressure control, and lower Framingham risk scores;
   2. Increased utilization of preventive services (e.g. MOVE!, TeleMOVE!, Healthy Lifestyles, etc);
   3. Improved health behaviors (e.g. making dietary and exercise changes); and
4. Develop, implement and assess strategies to recruit, train, and integrate peer CHW health coaches within the PCMH model.

This study will test a scalable model of peer health coaching to address the millions of patients at risk for Diabetes Mellitus (DM),using low cost, culturally congruent personnel to promote prevention of DM in PCMH practice.

Eligibility Criteria:
Inclusion Criteria:

* Having at least one HbA1c result in the prediabetic range (5.7-6.5%) in the 5 years prior to the start date of Phase 2.

Exclusion Criteria:

* A diagnosis of DM, based on ICD-9 codes applied during ambulatory encounters in the 2 years prior to Phase 2
* Treatment with DM medication other than metformin (e.g. insulin or oral agents)
* age greater than 75 years
* exclusion by patient's PCP due to contraindication for lifestyle intervention or CHW outreach.
* Does not speak English or Spanish (necessary to communicate with community health worker)
ANI-guided Intraoperative Analgesia vs Conventional Intraoperative Analgesia

This study evaluates the effects of Analgesia Nociception Index (ANI)-guided intraoperative analgesia on postoperative pain in patients undergoing open gynecologic surgery.

Postoperative pain is one of the most common postoperative complications and is significantly associated with patient's quality of recovery. Analgesia Nociception Index (ANI) is known to analyze the high frequency component of heart rate variability in relation to respiratory frequency, providing the objective information on the degree of pain. However, most previous studies conducted by using ANI were observational studies or small-sized randomized controlled studies. In the present study, the investigators aimed to evaluate the effects of ANI-guided intraoperative analgesia on moderate-to-severe postoperative pain by performing randomized controlled study.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18
* Elective open gynecological surgery
* American Society of Anaesthesiologists physical status classification 1-3

Exclusion Criteria:

* Laparoscopic surgery or robot-assisted surgery
* Patients who had analgesic agents, anti-psychotic agents, anticonvulsants which were related to chronic pain
* Patients who had hypersensitivity to analgesic agents or medications related anesthesia.
* Patients who were required to have mechanical ventilation after surgery
* Patients who had arrhythmia
* Patients who transferred to the surgical intensive care unit immediately after surgery
* Pregnancy
Diagnostic Performance of Endocytoscopy for Colorectal Lesions

Colorectal cancer is the third most common malignancy worldwide and the second leading cause of cancer-related death. About 70% of colorectal cancers develop through the adenoma-cancer pathway. Early detection and resection of colorectal neoplastic lesions significantly reduce the morbidity and mortality of colorectal cancers. Colonoscopy is considered to be the preferred method for screening for colorectal lesions. However, as the number of endoscopic resection increases, the costs associated with pathological diagnosis of endoscopic resection and resection specimens increase year by year. In clinical practice, it will be very important and urgent to correctly judge the nature of colorectal lesions to avoid pathological diagnosis and then realize optical biopsy. Therefore, to clarify the endoscopic diagnosis of colorectal lesions, many endoscopic techniques have been applied clinically. Such as narrow-band imaging, magnifying narrow-band imaging endoscopy, magnifying chromoendoscopy and endocytoscopy. Endocytoscopy has two modes, EC-NBI mode and EC-staining mode. EC-NBI mode is to observe the microvessel on the mucosal surface of colorectal mucosa after switching the endoscopy to NBI mode. EC-V pattern is used to observe microvessels and then endoscopic diagnosis is performed. The EC-staining mode was that the cell nuclei and glandular duct morphology of colorectal lesions could be observed by endocytoscopy after chemical staining. Endocytoscopic diagnosis is performed clinically after observation of glandular ducts and nuclei. However, current studies on the diagnostic value of endoscopy in colorectal lesions are all retrospective studies with small samples, and there is a lack of clinical studies based on chinese population. Therefore, our center intends to conduct a study of a large sample to explore the diagnostic value of endoscopy in colorectal lesions.


Eligibility Criteria:
Inclusion Criteria:

* colorectal lesions

Exclusion Criteria:

* non-epithelial tumors
* a history of inflammatory bowel disease
* lesions without clear EC images
* specific pathological types
* familial adenomatous polyposis