cyrilzakka/clinical-trials huggingface dataset:
Correlation Between Ultrasonography Finding and Shoulder Range of Motion in Stroke Patients

Limitation of range of motion in the shoulder joints is common in stroke patients. The causes are stiffness, CRPS, and frozen shoulder. The purpose of this study was to investigate the relationship between frozen shoulder and shoulder LOM in patients with cerebral infarction using ultrasonography.

Ultrasound examination was performed on 50 patients with limited range of motion of the shoulder joint among inpatients or outpatients in the Department of Rehabilitation Medicine of our hospital, who had a stroke of fewer than 2 years, and the findings suitable for adhesive capsulitis, namely the thickness of the joint capsule in the axillary concave Identify those with thickened findings. Their shoulder power rating, passive range of motion, stiffness evaluation (Modified Ashworth Scale, MAS), and the presence or absence of Reflex Sympathetic Dystrophy (RSD) were evaluated, and the relationship with ultrasound findings was investigated.

Eligibility Criteria:
Inclusion Criteria:

* Those who have been diagnosed with a stroke through CT or MRI within the last 2 years
* Those who are over 19 years old
* Those who have limitations in the range of motion of the shoulder joint

Exclusion Criteria:

* Those diagnosed with adhesive arthritis prior to the onset of stroke
* Patients with a severe shoulder trauma
* Those who performed shoulder surgery
Effects of Evolocumab on Platelet Reactivity in Patients With Diabetes Mellitus

Prospective, single center, double-blind, randomized pharmacodynamic experimental study. The study will enroll 150 subjects with ASCVD on optimal statin therapy as per physician and Diabetes Mellitus (DM) undergoing elective Percutaneous Coronary Intervention (PCI). Eligible patients will be randomized for 30 day treatment to either 1) evolocumab 420 mg ; or 2) placebo.

This is a double-blind randomized clinical trial of evolocumab versus placebo in patients with ASCVD and DM on clopidogrel and aspirin undergoing PCI. The study is aimed to assess

1. the effect of evolocumab therapy on platelet activation and reactivity;
2. the effect of evolocumab on biomarkers of platelet activation and inflammation.

Eligible patients will be randomized prior to start the PCI equally to either:

1. 420 mg evolocumab ; or
2. placebo. The randomized treatment will be administered in subcutaneous injections.

The laboratory assessments will be performed before (baseline), and 16-24 hours and 30-days after randomization.

Subject participation will be 30 days from the randomization.

Eligibility Criteria:
Inclusion Criteria:

* Diabetes Mellitus
* Dyslipidemia
* Undergoing elective PCI

Exclusion Criteria:

* Patients with recent Acute Coronary Syndrome (≤1 month)
* Patients on dual antiplatelet treatment (DAPT) with ticagrelor or prasugrel
* Patients undergoing urgent/emergent PCI for stent thrombosis
* Severe acute or chronic medical or psychiatric condition
* Pregnancy
* Participation in another experimental clinical trial, without formal approval
* Unwillingness or inability to comply with the requirements of this protocol
WristArt Total Wrist Arthroplasty Implant First In Human Study

The WristArt implant will be implanted for the first time in humans' wrists


Eligibility Criteria:
Inclusion Criteria:

1. Subjects suffering from one the following conditions:

   1. Osteoarthritis (OA) of the wrist joint due to various causes (age, trauma, Avascular Necrosis)
   2. Rheumatoid arthritis of the wrist joint or other rheumatological diseases which destroy the wrist joint
   3. Unrepairable previous intraarticular fractures of the distal radius, scaphoid or lunate bones of the wrist joint (i.e., historical fractures that were failed to fuse surgically)
   4. Symptomatic congenital abnormalities around wrist joint such as carpal bones coalition, mild forms of Madelung's deformities etc.
   5. Patients who underwent failed proximal row carpectomy, or failed partial carpal bones fusion
2. Patients who's their wrist x-ray shows no damage to the carpal bones that are not fused as part of the surgery
3. Patient Rated Wrist Evaluation Score (PRWE) at baseline is above 70 points out of 100
4. Visual Analog Pain Score (VAS) at baseline is above 70 points out of 100

Exclusion Criteria:

1. Patients younger than 18 years old
2. Patients for whom bone growth did not complete yet
3. Paralytic hand patients
4. Patients with sensitivity to Titanium (ADD/CHANGE MATERIALS AS NEEDED)
5. Cerebral palsy patients with wrist joint contracture and loss of sensation in the hand
6. Low quality of capitate bone and/or excessively short capitate bone (≥50% destruction) due to various causes (AVN, comminuted fracture, lytic lesions, congenital etc.)
Nasal High Flow to Maintain the Benefits of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients

Chronic obstructive pulmonary disease (COPD) is a major cause of disability and mortality worldwide. This systemic disease progressively leads to dyspnea and exercise capacity impairment. Pulmonary rehabilitation effectively improves exercise capacity, dyspnea and quality of life in patients with COPD. However, its benefits progressively fade over time due to several factors such as the lack of regular exercise activity, dyspnea, airway secretions, hematosis impairment and acute exacerbations which can lead to hospitalization and accelerated muscle wasting.

Nasal high flow (NHF) is a support used to deliver heated and humidified high flow air (up to 60 L/min) through nasal canula providing promising physiological benefits such as positive airway pressure or upper airway carbon dioxide washout. It can be used in association with oxygen and offers the advantage to overtake the patient's inspiratory flow, providing a stable inspired fraction of oxygen. Nasal high flow has widely been studied in pediatric and adult intensive care units and seems better than conventional oxygen therapy and as effective as noninvasive ventilation with regards to mortality to treat hypoxemic acute respiratory failure.

More recently, several studies have shown that long-term nasal high flow could contribute to improve exercise capacity, dyspnea, airway secretion removal, hematosis, reduced acute exacerbations and subsequent hospitalizations in patients with COPD.

Based on these results, the primary aim of this study is to assess whether long-term nasal high flow treatment can help COPD patients to better maintain their endurance capacity following a course of pulmonary rehabilitation.

Experimental design:

Patients achieving their last pulmonary rehabilitation session will be approached to participate in this study.

Eligible patients who agree to participate in the study and sign informed consent will perform two baseline visit assessments:

First visit: Incremental cardiopulmonary exercise testing. Second visit: Other baseline assessment (see outcome section), including a constant workload exercise testing at 75% of the maximal workload achieved during the incremental exercise testing.

Then, patients will then be randomized to one of the following two arms:

* Nasal high flow,
* Usual care.

After 6 months, patients will be invited to perform the same assessment as during the second baseline visit.

Eligibility Criteria:
Inclusion Criteria:

* Chronic obstructive pulmonary disease stage III to IV;
* With or without long-term oxygen therapy;
* Having completed a course of pulmonary rehabilitation within the last 4 weeks (at least 18 sessions).

Exclusion Criteria:

* Did not complete a course of pulmonary rehabilitation;
* Using noninvasive ventilation or constant positive airway pressure treatment;
* Tracheostomy;
* Nasal high flow intolerance;
* Pregnancy or likely to be;
* Unable to consent;
* Patients under guardianship.
Using the Transconjuctival Approach Alone Versus Using it Together With Lateral Canthotomy in Orbital Fractures

All cases will undergo surgery under general anesthesia. Evaluation of patients with suspected orbital fracture should involve radiologic examination, motility test, diplopia field test and exophthalmometry. Plain X-ray films, although rarely used, with the Caldwell and Waters view may be done as a screening evaluation for possible fractures and foreign bodies. An orbital computed tomography, the gold standard in trauma, CT with contiguous thin axial and coronal sections should be ordered to confirm the diagnosis and plan for treatment

Postoperative care:

Proper postoperative instructions will be given the patient, in addition to the postoperative medications including antibiotics, corticosteroids and analgesics.

This study will be carried out on patients attending the outpatient clinic in Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University.

10. Eligibility criteria:

* Inclusion criteria:
* Age group: from 15 to 60 years old.
* Patients with pure blow-out fractures.
* Exclusion criteria:

  * Patients suffering from dermatological diseases,

    11. Interventions:
    1. Pre-operative phase:

       Patients will be subjected to:
       1. Case history including personal data, medical, surgical and family history.
       2. Clinical examination.
       3. Preoperative anesthesia assessment for fitness for general anesthesia.
       4. Treatment planning.
    2. Operative phase:

       All cases will undergo surgery under general anesthesia. The inferior wall can be easily accessed through transcutaneous or transconjunctival approach (with or without lateral canthotomy). The latter avoids a visible scar and is less likely to result in eyelid retraction. The medial wall can be accessed through transcaruncular approach. Careful exploration under the periosteum allows easy visualization of the fracture boundaries as well as correction of the herniated tissue.

       Then various implants can be used to support the orbital soft tissue and prevent recurrent herniation. Porous polyethylene sheets (Medpor) are one of most commonly used implant materials. Other autogenous (cranial, rib or iliac bone graft) or alloplastic (gelatin film, silicone sheet, Teflon, Supramid, titanium mesh or bioresorbable copolymer plates) materials are also available.

       Periocular fractures are often managed first by the ophthalmologist. With good clinical examination and radiographic imaging, an informed decision can be made whether surgical intervention is required.
    3. Postoperative care:

Proper postoperative instructions will be given the patient, in addition to the postoperative medications including antibiotics, corticosteroids and analgesics.

Eligibility Criteria:
* Inclusion criteria:
* Age group: from 15 to 60 years old.
* Patients with blow-out fractures.
* Exclusion criteria:

  * Patients suffering from dermatological diseases,
Skin-to-skin Contact Time and Maternal Psychology

The aim of this study was to determine the effect of postpartum skin-to-skin contact time on fear of childbirth, birth trauma and maternal attachment.

This is a single-blind, randomized controlled trial. Data were collected from 110 women who gave birth in the gynecology clinic of a public hospital in southern Turkey between September 2021 and February 2022. Participants who met the inclusion criteria were informed about the purpose of the study and skin-to-skin contact, informed consent was obtained from those who agreed to participate, and the women were divided into groups according to a 1:1 computer-based randomization program. Data were collected at the time of consent to the study, within the first hour after birth, 24 hours after birth, 4 weeks postpartum, and 4 months postpartum. Collected by the first author. The CONSORT directive was followed in the planning, implementation and writing of the research.

Eligibility Criteria:
Inclusion Criteria

* Must be able to a normal term vaginal delivery,
* Native language is Turkish,
* Have single fetus
* Must be able to skin to skin contact wit her baby

Exclusion Criteria

* Cesarean section,
* Complications,
* Psychological or psychiatric disorder,
Nesiritide Use Following Cardiac Surgery in Infants

The purpose of this study is to determine the effects of nesiritide on urine output and hemodynamics following cardiopulmonary bypass in infants. Safety and pharmacokinetic data will also be obtained.

Nesiritide, a recombinant human B-type natriuretic peptide, has vasodilatory, lusitropic and diuretic properties in healthy humans, and improves hemodynamics and symptoms in adults with decompensated congestive heart failure. Several retrospective case series suggest that nesiritide has beneficial effects on hemodynamics and urine output in adults and children following cardiac surgery.

The purpose of this prospective, randomized, double-blind, crossover study is to evaluate the effects of a continuous infusion of nesiritide on postoperative hemodynamics and urine output in infants with congenital heart disease who undergo cardiac surgery requiring cardiopulmonary bypass (CPB). Patients less than 1 year of age following cardiac surgery will be eligible for the study if they have received two conventional diuretics (furosemide and chlorothiazide) for at least 12 hours, yet are not effectively achieving a negative fluid balance, thus prohibiting sternal closure or tracheal extubation. Patients will be randomized to receive either a 10-hour infusion of nesiritide, a two hour washout period, followed by a 10-hour infusion of placebo, or this study drug sequence in reverse order. During the 24-hour study period, serial cardiac output measurements and BNP levels will be obtained, vital signs and intracardiac filling pressures will be recorded, and urine output will be measured.

Eligibility Criteria:
Inclusion Criteria:

* \> 48 hours after cardiac surgery requiring cardiopulmonary bypass
* \< 1 year of age
* Receiving chlorothiazide and furosemide for \> 12 hours
* Urine output \< 4 cc/kg/hour, or fluid intake \> output for 2 consecutive days
* Receiving mechanical ventilation
* Presence of body wall edema on CXR, defined as a radiologic index of \> 2
* Plan for \> 24 hrs further diuresis before chest closure or extubation

Exclusion Criteria:

* Age \> 365 days at the time of enrollment
* Corrected estimated gestational age \< 35 weeks at the time of enrollment
* Serum creatinine \> 2.0 mg/dL at the time of enrollment
* Significant hemodynamic instability at the time of enrollment
* Lack of dedicated intravenous access for nesiritide infusion
* Lack of arterial line for continuous blood pressure monitoring
* Lack of a Foley catheter for continuous urine collection
* Enrollment in another research study such that the outcomes of either study may be confounded by participation in this study, or such that the amount of blood drawn for research purposes becomes excessive.
Ambulosono Rasagiline Musical Walking Study

This study will investigate the effects of a contingency-based musical walking intervention program called Ambulosono on neural mechanisms in the brain. The investigators will investigate the long-term impact of Ambulosono on brain plasticity with functional MRI technique. Participants will undergo 3 months of Ambulosono training and their pre-training and post-training fMRI brain scans will be compared to understand the neural networks and brain mechanisms following this intervention. The investigators hypothesized that Ambulosono may induce functional compensatory reorganization of neural networks in the brain. This project will allow us to address the important potential confound of placebo influence and to aid in optimizing this intervention program. Additionally, the investigators are hoping to investigate the synergistic effects of rasagiline and exercise; the investigators' hypothesis is that there will be a positive synergistic effect, and that exercise will augment the effectiveness of rasagiline in treating Parkinson's symptoms.


Eligibility Criteria:
Inclusion Criteria:

* Over 19 years of age
* Confirmed diagnosis of Parkinson's Disease
* Can walk 5 to 10 minutes unassisted
* Have a safe place to walk (outdoor or indoor)
* Have mild to moderate Parkinson's disease (HY1-3)
* Be able to lay flat in the scanner for the period of the study
* No reliance on wheelchair or other walking aid for ambulation
* Absence of any other serious medical conditions such as hearing impairment and dementia
* No history of other neurological and psychiatric illnesses
* No recent musculoskeletal impairment or injuries that may prevent walking

Exclusion Criteria:

* Under 19 years of age
* Unconfirmed PD diagnosis
* Require walking aid, wheelchair-bound
* No access to safe walking pathway
* Severe PD (Hoehn \& Yahr stages\>3)
* Impaired hearing
* Atypical Parkinsonism
* Concurrent dementia
* Recent knee, hip or foot injury (need permission from doctor)

Exclusion Criteria for fMRI

* Pacemaker
* Brain aneurysm clip
* Cochlear implant
* Recent surgery within the past 6 weeks
* Possibility of pregnancy
* Electrical stimulator for nerves or bones
* Implanted infusion pump
* History of any eye injury involving metal fragments
* History of working with metals (grinding, machining, or welding)
* Artificial heart valve
* Orthopaedic hardware (artificial joint, plate, screws, rods)
* Other metallic prostheses
* Coil, catheter or filter in any blood vessel
* Ear or eye implant
* Recent tattoos within the past 6 weeks
* Shrapnel, bullets, or other metallic fragments
* Medication releasing skin patches (nicotine, birth control, nitroglycerine)
Efficacy and Safety of Impracor (Ketoprofen 10% Cream) Compared With Placebo in the Treatment of Acute Pain (Flare) Associated With Osteoarthritis of the Knee

The primary objective of the study is to assess analgesic efficacy of Impracor (Ketoprofen 10% Cream) compared to placebo for acute pain associated with OA flare of the knee.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of OA of the knee according to the ACR criteria.
* Kellgren-Lawrence grade 2-3 disease
* Be willing to stop taking all analgesics including NSAIDs and opioids for the duration of the study, with exception of study-specified rescue medication.

Exclusion Criteria:

* Total knee replacement surgery tentatively scheduled within next 6 months.
* Palpable knee effusion.
* Significant pain outside the target knee, including significant hip, back, or contralateral knee pain.
* Any type of orthopedic and/or prosthetic device or any skin abnormalities on the target knee that would prevent evaluations of local tolerability.
* History of asthma, rheumatoid arthritis, chronic inflammatory disease (e.g., colitis), or fibromyalgia.
* History of gastrointestinal bleeding or peptic ulcer disease within the past 3 years.
* Have a positive urine drug test for illegal drug substances, non-prescribed controlled substances, or alcohol at screening.
* Acute or chronic illness that in the opinion of the investigator could compromise the integrity of study data or place the subject at risk by participating in the study.
An Observational Study of Local Relapse After High Grade Osteosarcoma

multicenter retrospective and prospective study in patients with high-grade osteosarcoma

This is a multicenter retrospective and prospective study that will analyze all cases with of diagnosis of local relapse in high-grade osteosarcoma from 01 January 1980 and all new cases referring to each participant site.

Eligibility Criteria:
Inclusion Criteria:

* Patients who experienced LR as first event of recurrence after treatment for localized high-grade osteosarcoma of bone, including cases with synchronous lung metastases
* Adequate patient compliance to follow-up visits
* Written informed consent prior to any study-specific analysis and/or data collection
* No age limits

Exclusion Criteria:

* Cases of LR demonstrated after \> 3 months after metastatic disease
* Impossibility to ensure adequate compliance
Behavior Problems Prevention Using the Online Triple P Parenting Program

The Triple P program is a comprehensive system of parenting and family support of multilevel preventive intervention, developed for families with members up to 16 years of age, whose objective is to improve parenting skills and prevent or modify dysfunctional parenting practices, thus reducing Family risk factors that affect both child abuse, behavioral problems and emotional problems.

Based on the importance that evidence-based parental interventions have acquired and the need from the health field to provide innovative alternatives that facilitate access to this type of services, parental support programs given through the web emerge. There is evidence that supports the idea that parenting programs taught through the web have an influence on reducing disruptive behaviors in children.

Triple P Online (TPOL) is an adaptation of the Positive Parenting Program, Triple P, a program that has been empirically tested. This adaptation is a parental intervention through the web with self-directed modality, which is based on Level 4 of the Triple P parental program and is configured in 8 interactive sessions with online modules. The topics covered are: 1) What is Positive Parenting, 2) Reinforcing the behavior we want, 3) Teaching new skills, 4) Managing negative behaviors, 5) Managing disobedience, 6) Preventing problems through planning, 7) Making fun outings, 8) Raising confident and competent children.

The main results observed in the implementation of the online Triple P program are (Sanders et al, 2012): reduction of problem child behavior, dysfunctional parenting styles, increasing parents' confidence in their parenting role, and reduction of parental anger.

Eligibility Criteria:
Inclusion Criteria:

* Belong to one of the three socio-economic levels according to SIMCE classification (High, Medium and Low).
* Attend to a primary school of the Municipality of Lo Barnechea, Santiago, Chile.
* Previous participation in the instruments validations stages.
* Identification in The Strengths and Difficulties Questionnaire (SDQ) with behavior problems above the 80th percentile.
* Have Internet access.

Exclusion Criteria:

* Attend to a school that is developing or implementing a manualized program for parents associated with the prevention of behavioral problems
* Participating in a similar study.
Detecting Sepsis in Patients With Severe Subarachnoideal Hemorrhage

The study aims to evaluate the suitability of the SOFA score implemented by the Sepsis 3 guideline to detect sepsis in patients suffering from subrarachnoid hemorrhage.


Eligibility Criteria:
Inclusion Criteria:

Critically ill patients suffering from moderate to severe subarachnoid hemorrhage (WFNS \>2).

Exclusion Criteria:

children under the age of 18 years Patients with minor subarachnoid hemorrhage \< WFNS stage 2.