cyrilzakka/clinical-trials huggingface dataset:
Incentive Spirometer as a Visual Feedback in Children With Spastic Cerebral Palsy

Objective: To compare the effects of incentive spirometer as a visual feedback versus deep breathing via mirror mediated therapy on pulmonary function in children with spastic cerebral palsy. To determine the effects of incentive spirometer as a visual feedback versus deep breathing via mirror mediated therapy on sleep and quality of life in children with spastic cerebral palsy.


Eligibility Criteria:
Inclusion Criteria:

* Participants falling in this category would be recruited into the study.
* Spastic diplegic, age above 5.
* According to modified Ashworth scale, moderate spasticity 1 to 3.
* Adequate cognition (will be assessed by using MMSE scale) in order to follow the instructions to use Incentive Spirometry and also able to comprehend single verbal command for breathing.
* Able to attend all sessions. (mentally and physically capable of attending session).
* Able to sit with support.

Exclusion Criteria:

* Participant falling in this category would be excluded of the study.
* Patients with any respiratory or cardiac disease that can affect their respiratory function.
* Patients with beta blockers or bronchodilators.
* Children with any cognitive impairment who are unable to follow instructions.
* Children with bone deformities, such as scoliosis or kyphosis.
* Children with any sort of auditory and visual defects.
Total Hip Arthroplasty: Fluoroscopy vs Freehand

The aim of the study is to compare total hip arthroplasty intervention executed with or without the use of intraoperative fluoroscopy in terms of positioning of the hip prosthesis. The comparison will be made on post-operative follow-up X-ray performed as per clinical practice, in order to verify if intraoperative fluoroscopy provides better prosthesis components positioning or not.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing unilateral primary THA through DAA
* Patients aged 18-90 years old.
* Patients with a BMI \>18 and \<35.
* Patients able to provide informed consent.
* Informed consent as documented by signature.

Exclusion Criteria:

* Revision THA.
* Women who are pregnant or breast feeding.
* Presence of other clinically significant concomitant disease states (ASA IV).
* Previous enrolment into the current study.
* Enrolment of the investigator, his/her family members, employees and other dependent persons.
Feasibility, Safety and QoL After Merendino Procedure

The purpose of this study is to analyse retrospectively the early postoperative and functional outcome of patients (pts) after Merendino procedure for benign or early malignant lesions of the distal part of the esophagus or the gastroesophageal junction.

Between 2004 and 2013, 14 pts had transhiatal resection of median 8 (6-10) cm of distal esophagus including the gastroesophageal junction. Locoregional lymphadenectomy was performed in all patients with (suspected) early adenocarcinoma. In case of vagus nerve resection, pyloromyectomy and cholecystectomy were done. A pediculated isoperistaltic jejunal segment of 15-18 cm length was interponed between esophageal stump and remaining stomach by end-to-side anastomoses. At least one postoperative contrast examination of the anastomoses was done in all pts. Quality of life was assessed by using the EORTC QLQ-OES18 survey, recording patients' general activity and condition and specific gastrointestinal symptoms.

Eligibility Criteria:
Inclusion Criteria:

* alive
* MER or CON procedure
* informed consent
* CON patients were matched according to diagnosis, Age and ASA score

Exclusion Criteria:

* withdrawal of informed consent
* legal incapacity
* limitations in mental state or medical condition precluding questioning (only QoL data)
Blood Flow Restriction Training in Pre-frail and Frail Older Adults

Frailty is most often defined as a syndrome of physiological decline in late life, characterized by marked vulnerability to adverse health outcomes. Intervention such as exercise, especially resistance exercise, has proven to be effective to improve frail condition in the elderly in the previous literature. However, blood flow restriction (BFR) training, a new resistance exercise training method, need merely lower resistance power and shorter training duration compared with traditional resistance exercise. Previous researches also demonstrated BFR can increase muscle mass and muscle strength in the healthy elderly but the effect of BFR training on the pre-frail or frail elderly is unknown. The aim of this study will test the effect of BFR training on muscle strength and functional performance in pre-frail or frail elderly. Participants aged over 60 years old with clinical frailty score between 3 to 5 will be recruited. Participants will be assigned to two groups using randomized block design with BFR training and control group. Structured questionnaire and physical function measurement will be used to assess the pre-intervention condition and outcome of different interventions. The participants will be assessed before training (pre-test), 3 weeks after training, and 6 weeks after training (post-test), and followed up at one and three months after training. Physical function measurement will include hand grip, muscle mass over trunk and extremity, muscle strength of lower extremity, gait speed and timed up and go test. Two-way repeated measures analysis of variance will be used to test the pre-test, 3-week, post-test and follow-ups difference between the two groups.


Eligibility Criteria:
Inclusion Criteria:

* Aged over 60 years old
* Fried frailty index fulfill 1-2 criteria
* Able to walk 6 meters independently
* Able to understand and follow ≥ 3 instructions

Exclusion Criteria:

* Severe hypertension (\>180/110mmHg)
* Peripheral neuropathy
* History of deep-vein thrombosis (DVT)
* Cardiovascular diseases (i.e. Heart failure NYHA Classification III or IV, myocardial infarction, pulmonary hypertension, coronary artery stenosis)
* Neuromuscular diseases (i.e. Stroke, Parkinsons' disease)
* History of resisted exercise training program within the last 6 months before screening
Feasibility of Fluorescence Imaging with Bevacizumab-800CW During Bronchoscopy

In this feasibility study, bronchoscopy will be combined with fluorescence molecular imaging using the near-infrared fluorescence (NIRF) tracer bevacizumab-800CW for assessment of pulmonary lesions and/or lymph nodes considered to be malignant.


Eligibility Criteria:
Inclusion Criteria:

1. Signed informed consent prior to participation in the study.
2. Age ≥ 18 years.
3. Patient has at least one intrabronchial, near-to-airway located or peripheral pulmonary nodule - with or without pathological lymph nodes - which is considered malignant (independent of its primary origin).
4. Patient is considered fit to undergo a diagnostic and/or therapeutic bronchoscopy (with or without addition of virtual navigation and/or endobronchial ultrasound; including propofol sedation or general anesthesia if either is indicated) to obtain tumor material according to standard care protocols.

Exclusion Criteria:

1. History of infusion reactions to bevacizumab.
2. Medical or psychiatric conditions that compromise the patient's ability to give informed consent.
Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). While genetic testing has become central to prostate cancer care, African American men are less likely seek testing due to lack of awareness, cultural beliefs, financial limitations, fear of discrimination, and mistrust in the healthcare system. A network of peer genetic coaches may help address barriers, beliefs, and needs of African American men in the community and provide navigation to increase engagement in genetic testing.

PRIMARY OBJECTIVES:

I. Identify and train 6 African American (AA) men as peer genetic coaches (PGCs) for the Extending Prostate Genetic Awareness, Navigation, and Delivery (EXPAND) Network. (Train peer genetic coaches) II. Conduct a feasibility study of peer genetic coaching. (Provide individual coaching)

SECONDARY OBJECTIVE:

I. Patient-related outcomes will include change in decisional conflict for genetic counseling, acceptability/attitude toward genetic counseling and testing, and change of genetics knowledge.

OUTLINE:

AIM 1: Peer genetic coaches undergo training and education on study.

AIM 2: Patients receive an educational booklet and attend a discussion with a peer genetic coach on study.

Eligibility Criteria:
Inclusion Criteria:

* AIM 1: Are 18 years old or older
* AIM 1: Are able to read and speak English comfortably
* AIM 1: Men who have experience with both prostate cancer (PCA) and genetic counseling and testing will be a priority for training, as well as men who have considerable peer education or navigation experience
* AIM 2: Are 18 years old or older
* AIM 2: Are African American
* AIM 2: Are able to read and speak English comfortably
* AIM 2: Men who meet any one of the following criteria: (1) metastatic prostate cancer; (2) prostate cancer with high-risk features (T3 or higher, Gleason 8 or higher, node positive disease); (3) with or without a diagnosis of prostate cancer with strong family history (2 or more first-degree or second-degree relatives) with prostate cancer (particularly metastatic prostate cancer or died from prostate cancer), breast cancer, ovarian cancer, pancreatic cancer, colorectal cancer, uterine cancer, renal cancer, urothelial cancer, or upper bowel cancer

Exclusion Criteria:

* Patients that do not meet the inclusion criteria
* Children under the age of 18
* Anyone who has trouble understanding the consent or with significant anxiety detected during the consent process
Investigation of the Clinical Outcomes of Endocrowns Manufactured From Three Different Materials

The goal of this clinical trial is to examine the durability of endocrowns, created using various materials and manufacturing techniques with a fully digital workflow, and their ability to maintain functionality and aesthetics in the oral cavity.

The main questions it aims to answer were does effect of different materials on clinical success?

Based on the power analysis, it was determined that restorations would be applied to 11 teeth in each of the three material groups (lithium-disilicate reinforced glass-ceramic, polymer infiltrated ceramic, and 3D-printed permanent hybrid resin) as well as the control group (n=11). A total of 33 teeth received endocrown restorations. Additionally, 11 patients were directly restored with composite resin in molar teeth with MOD cavities.

The digital impressions of the patients receiving endocrown restorations were recorded using an intraoral optical scanner and sent to a specialized dental laboratory. For two of the groups (lithium disilicate-reinforced glass-ceramic, polymer infiltrated ceramic), restorations were fabricated using block milling, while for the third group (permanent hybrid resin), restorations were produced through 3D printing. The restorations were cemented adhesively. The restorations were evaluated using the Modified FDI and Modified USPHS criteria at baseline (0) and at the 6-month follow-up, and the data were subjected to statistical analysis.

At the 6-month evaluation, a statistically significant difference in color match was found between the groups based on the Modified FDI criteria, whereas no statistically significant differences were observed for any of the Modified USPHS criteria. All endocrowns produced with the three different materials survived and showed clinical success at the 6-month follow-up. Nevertheless, additional clinical studies with extended follow-up durations are required.

Eligibility Criteria:
Inclusion Criteria:

* Must be a lower or upper molar tooth
* Must be periodontal healthy
* There must be at least two axial walls in the relevant tooth
* Gingival steps should be at gum level
* There must be neighboring teeth mesial and distal to the relevant tooth.
* The place where it occludes must be the opposing tooth and the tooth must be a natural or filled tooth without a prosthesis.
* No systemic acut or chronic conditions (Thyroid disease, Alzheimer's Disease, Insulin dependent diabetes, etc.)

Exclusion Criteria:

* Inadequate oral hygiene, bleeding on probing, pocket deeper than 3 mm mobility presence
* Sensitivity to percussion after root canal treatment
* Insufficient enamel tissue remaining in the relevant tooth
* Presence of radiographically abnormal periodontal space
* Teeth with inadequate bone support
* Teeth with root resorption and fracture
CPAP Adherence Pilot Study Among African Americans

The goal of the study is to determine the feasibility of a behavioral intervention to improve CPAP adherence among African American patients with obstructive sleep apnea.

The Investigators propose to pilot test a couple-oriented intervention in a randomized controlled trial of 20 African American patients diagnosed with moderate to severe OSA and their partners. Half of the patients will receive optimal usual care currently implemented at MetroHealth, consisting of sleep therapist-initiated standardized education about OSA, sleep hygiene, and CPAP use; personalized mask fittings; and follow-up at 1 week to troubleshoot problems with CPAP utilization. Participants will follow up with their sleep providers per usual. The remaining patients and their bed partners will receive a couple-oriented intervention consisting of guideline-recommended best practices for improving CPAP adherence consisting of sleep therapist-initiated standardized education for couples about OSA, sleep hygiene, and CPAP use; personalized mask fittings; and follow-up at 1 week to troubleshoot problems with CPAP utilization. Couples will participate in two couple-oriented support groups led by an African American patient with long standing OSA treated with CPAP and their partner. Patients and partners will receive tailored text messages encouraging adherence. In addition, couples will receive five 60-minute virtual cognitive behavioral couple therapy sessions with a health psychologist trained in behavioral sleep medicine that will focus on enhancing couples' knowledge of CPAP, patients' self-efficacy to use CPAP, couple's relationship dynamics, and partners' skill and self-efficacy in assisting the patient with CPAP adherence.

Eligibility Criteria:
Inclusion Criteria:

* Must have same bed partner(s) for at least 6 months.
* Must be at least 18 years of age

Exclusion Criteria:

* Must be Proficient in speaking English
* Non-compliance to management of OSA
* Apnea hypopnea Index ≥ 15 events/hours
* Terminally ill
* Mentally incompetent
* unstable housing
* need for BPAP or VPAP\\PAP).
Fluoride Varnish for Treatment of White Spot Lesions

Study will look at ability of fluoride varnish to remineralize white spot enamel lesions that can occur around the edge of fixed orthodontic brackets.

To determine the efficacy of 5% sodium fluoride varnish with tricalcium phosphate in reverting white spot lesions after fixed orthodontic treatment, compared with a fluoride gel.

Eligibility Criteria:
Inclusion Criteria:

* no systemic disease
* has completed fixed orthodontic treatment, brackets debonded
* has at least two teeth with whitre spot lesions
* has received conventional periodontal therapy after orthodontic tretament

Exclusion Criteria:

* presence of enamel hypoplasia or dental fluorosis
* presence of tetracycline pigmentation
* periodontal pocketing of 3mm or greater
* taking antibiotics
* presence of carious cavities
* allergy to fluoride gel / varnish being used in study
Proprioceptive Neuromuscular Facilitation Combined With Postural Education in Upper Cross Syndrome

The aim of this study was to investigate the effectiveness of PNF and conventional neck stretching, combined with a postural education program in improving forward head posture in students with clinical signs and symptoms of UCS. The study included a sample of undergraduate Gulf Medical University students with clinical signs and symptoms of UCS. A total of 24 samples were divided into two groups of 12. Group A received PNF pattern neck stretching and self-resisted neck PNF pattern, whereas Group B received Conventional neck stretches along with isometric strengthening of the neck muscles. Both groups were given a common postural education program. The intervention duration was 5 days per week for 4 weeks.

Collegiate students are prone to adopt slouched posture and develop muscular imbalance which is considered as a causative factor for the development of UCS. Studies have shown that students in medical universities have a higher risk of developing UCS. Even though PNF is considered to be simple and effective to improve inter and intramuscular coordination, its application to collegiate students with UCS is limited. Application of PNF combined with postural education programs may benefit the students to reduce UCS-associated clinical problems such as reduced forward head posture, pain intensity and improving muscle strength etc. Our current study might open the door of simple and effective management of UCS among collegiate students. Therefore, our study was conducted to find out the effect of PNF and active muscle stretching, both in combination with postural education programs, on forward head posture of the students with upper crossed syndrome.

Objectives:

● To compare the effect of PNF with active muscle stretching, both in combination with postural education programs on forward head posture of students with upper cross syndrome.

Eligibility Criteria:
Inclusion Criteria:

* Students of Gulf Medical University.
* Both genders.
* Age between 18 - 30 years.
* Presence of clinical signs and symptoms of UCS.
* Presence of FHP with CVA of 49 degrees and below.

Exclusion Criteria:

* Musculoskeletal disorder such as strain, sprain, scoliosis.
* Students participating in any other interventions.
* Nutritional deficiencies.
* Unwilling participate.
* Degenerative joint disorder
* Neurologically unstable individuals
Vaccination Study of Abatacept (BMS-188667) for Normal Healthy Volunteers

Study to assess the ability of healthy subjects to build anitbodies to tetanus and pneumococcal vaccines after receiving a single intravenous dose of Abatacept, a drug which is being developed for the treatment of Rheumatoid Arthritis and which can affect the immune system.


Eligibility Criteria:
Inclusion Criteria:

* Healthy Subjects
* Body Weight between 60 and 100 kg.
* Males and Females must be using adequate contraceptive methods during study and for 10 weeks after dose of study mediciation.

Exclusion Criteria:

* Females who are prgnant or breastfeeding
* History of autoimmune disorder, immunodeficiency, or infection within past 3 months.
* Active TB requiring treatment within the previous 3 years.
* Positive breast cancer screen, PPD test.
* Vaccination with tetanus or pneumococcal vaccine within 5 years.
* Vaccination with any live vaccine within 4 weeks.
* History of drug or alcohol abuse.
* Any significant allergy.
Hemodiasis Patients Using Virtual Reality Video

VR, with its developing technology, is a new technique used in the healthcare industry combined with cognitive technology to reduce the symptoms experienced by patients and to relieve the patient. This study investigates whether virtual tour environments created using virtual reality glasses have an effect on patients\&#39; vital signs, symptoms and comfort during the hemodialysis session. It is aimed to evaluate the effect of Virtual Reality Based Videos applied during hemodialysis treatment on Hemodialysis Symptoms, vital signs and Comfort.

Hemodialysis (HD) is one of the treatment options used to regulate renal functions in the treatment of chronic renal failure. In hemodialysis, patients have to cope with many problems during the treatment process as well as the disease. In addition, patients require HD treatment, which lasts three to four hours, three times a week on average. Factors such as having to go to a dialysis center for these treatments, patients having to continue their lives depending on the machine, restriction of movements during the session, increased dependency of the patient, deterioration in their adaptation to professional and social relationships affect the patients\&#39; daily life activities and reduce their comfort. With the developing technology, virtual reality, a new technique in the healthcare industry, has begun to be used in nursing care in order to reduce the symptoms experienced by patients and to comfort the patient.

The virtual reality device removes the patient from the environment with the glasses and headphones attached to the person\&#39;s head, along with the image on the screen and simultaneous sounds, and focuses his/her attention on the virtual video images. This study was planned as a randomized controlled study to evaluate the effect of virtual reality-based videos on hemodialysis symptoms and comfort in hemodialysis patients. The research was planned to be conducted with 50 hemodialysis patients. \&#34;Patient Introduction Form\&#34;, \&#34;Dialysis Symptom Index (DSI)\&#34;, \&#34;Vital Signs Monitoring Form\&#34;, \&#34;Hemodialysis Comfort Scale Version II\&#34; will be used to collect data. After the scales were applied, patients in the experimental group were exposed to virtual reality glasses for 30 minutes, twice a week for 8 weeks. The video will be watched. At the end of 8 weeks, the scales will be applied again and compared with the initial scale results.

As a result, in line with the findings obtained from the research, the effect of virtual reality application on dialysis symptoms, vital signs and comfort during hemodialysis treatment will be determined and suggestions will be made to encourage patients to use virtual reality methods in the environments where they are treated.

Eligibility Criteria:
Inclusion Criteria:

- Voluntarily over 18 years

Exclusion Criteria:

* reluctant
FAST Learning Methods

Training paramedics in new skills via classroom-based teaching has inherent costs and time constraints. The investigators sought to evaluate whether web-based didactics result in similar knowledge improvement and retention of FAST (Focused Assessment with Sonography for Trauma) compared with the traditional method.

Paramedics were randomized into a classroom group with traditional lectures and a web group that watched narrated lectures online. All participants completed a pre- and post-test, and a second post-test four weeks later. Both groups underwent hands-on training after the first post-test. A control group completed the two initial tests without didactic intervention.

Eligibility Criteria:
Inclusion Criteria:

* give voluntary consent to participate in the study emergency medical professionals (paramedics, nurses, physicians)

Exclusion Criteria:

* not meet the above criteria