cyrilzakka/clinical-trials huggingface dataset:
Evaluation of State and Shade of White Spot Lesions After Using Different Remineralizing Agents (An in Vivo Study)

The aim of the study is to evaluate the effect of Biomimetic remineralizing agent and resin modified glass ionomer varnish on color shade and state of white spot lesions immediately, after 3 months, and after 6 months. (An in vivo study).


Eligibility Criteria:
Inclusion Criteria:

1. Patients included in this clinical trial were less than 30 years old.
2. Patients with good general health.
3. Patients who will agree to the consent and will commit to follow-up period.
4. Fully erupted anterior teeth with no cavitated lesions.

Exclusion Criteria:

1. Patients with any systemic disease that may affect normal healing.
2. Patient with bad oral hygiene.
3. Tetracycline or florosis staining.
4. Patients who could/would not participate in all times of follow-up.
5. Untreated periodontal disease was not allowed.
6. Active caries or defective Restorations in 6 anterior teeth.
7. Bleaching history
8. Patients participating in more than 1 dental study.
9. Patient received fluoride varnish before.
Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults

The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal weight versus overweight/obese South Asian adults.

Participants will attend a preliminary testing session where height, weight, body fat and waist circumference will be measured. They will be familiarised with a motorised treadmill that will be used during the experimental visit below and will take part in an exercise test to determine a light-intensity walking speed for the experimental visit.

Participants will then attend two experimental visits in a random order:

1. Prolonged sitting: Participants will remain seated for 5 hours and instructed to reduce excessive movement.
2. Breaking up sitting with walking breaks: Participants will rise from the seated position every 30 minutes throughout the experimental period to walk on a motorised treadmill at a light intensity for 3 minutes. After performing walking activity, they will return to the seated position. In addition, blood sample will be taken at the resting position just before each physical activity bout. The activity breaks will be undertaken on 9 occasions, providing a total of 27 min of light intensity activity.

During each visit, blood pressure will be taken 11 times and blood samples will be taken 10 times. Participants will be given a breakfast and lunch meal to consume.

Eligibility Criteria:
Inclusion Criteria:

* Self-identified South Asian ethnicity.
* Self-report sitting at least 7 hours per day.
* Normal weight, overweight or obese.

Exclusion Criteria:

* Unable to speak and read English.
* Contraindications to performing light-intensity walking.
* Diagnosed cardiovascular disease or diabetes.
Assessment of Distal Limbs Fractures With Cone-Beam CT Newtom 5G

ConeBeam scanner (CBCT) is a widely technique used for dental and maxillofacial imaging. Patients can be set up in a sitting or a laying position in the, Newtom 5G CBCT allowing for an analysis of the distal appendicular skeleton. The investigators' hypothesis is that the cone-beam scanner could detect and characterize fractures of the extremities similarly to a multidetector CT (MDCT). 150 patients over 18 years requiring a CT scan for a suspected distal limb fracture or a preoperative assessment will be enrolled. The primary endpointis based on the ability of cone-beam scanner to properly characterize the type of fracture using a classification derived from Maurice E. Müller (AO) classification. Secondary endpoints will concern the depiction of the fracture, the assessment of the soft tissues near the fracture, quality of images, inter and intra-operator reproducibility and tolerance of the patient for the examination. Patients will have a MDCT considered as the reference exam, then a CBCT. Exams will be anonymized and read twice by two trained radiologists with 3-6 week intervals. The inter-observer agreement for the diagnosis of fracture type between the two techniques will be evaluated by a kappa coefficient. The evaluation of diagnostic performance will be achieved by studying the sensitivity, specificity, negative predictive value and positive predictive value, and its likelihood ratio. Kappa test will be performed to evaluate the consistency of the characterization of the fracture and the evaluation of soft tissue near the fracture. A Student t test will be performed for paired data if distributions are normal, a Wilcoxon test if not. To assess patient's tolerance, the percentages of (painful, not painful) will be calculated for each technique and will be compared using the Chi2 test (or Fisher's exact test if the chi can not apply).


Eligibility Criteria:
Inclusion Criteria:

* Patient age 18 years old or above, weight ≤ 160 Kg
* Patient require MDCT for a suspected distal limb fracture or a preoperative assessment
* French spoken an read
* Free and informed consent signed
* Being affiliated to a French social security system or similar.

Exclusion Criteria:

* Patients already included in the study for a previous fracture
* Patient with severe pain and reduced spontaneous mobility that could prevent proper positioning for the cone-beam
* Lack of effective contraception (risk of pregnancy) or pregnancy proven data on interrogations
* Patient on protection of the court, under supervision or trusteeship
* Inability to express a consent
* Patients already enrolled in a study with a conflict of interest with this study.
* The presence of osteosynthesis materiel or capital may interfere with image quality. A sample of 3 to 5 patients may be included at the beginning of the study to test the image quality in presence of material.
Synergy Between Patient and Clinician: Using a Trauma-Informed Care Plan

The goal of this prospective study is to test the: acceptability of trauma-informed care plans; the intervention appropriateness; and the feasibility of the trauma-informed care plans in the electronic health care record. Patient seen in various health care settings and how have complex health care needs will be invited to participate in this study. The aims to are:

Aim 1: Explore the acceptability of trauma-informed care plans, the appropriateness of trauma-informed care plans, and the feasibility of Trauma-Informed Care Plans(TICP) when used by clinicians on the health care team (HCTC). Hypothesis 1: HCTC using the TICP will report its acceptability, feasibility, satisfaction and ease of use. Hypothesis 2: HCTC will report heightened awareness of intersection of trauma and social determinants of health. Hypothesis 3: HCTC will report more awareness of the patient's unique preferences and will be better informed regarding the unique plan of care for their patient.

Aim 2: Explore the impact of having a TICP by patients understanding how the TICP may have improved their experience around care and treatment. Hypothesis 1: patients will report: improved satisfaction with their care. Hypothesis 2: patients will report feeling better known by HCT. Hypothesis 3: will report less stress and anxiety related to health care encounters.


Eligibility Criteria:
Inclusion Criteria:

* patients ( ages 18-60)
* who have frequent health care appointments
* have complex health care needs
* consent to participate in study
* English or spanish speaking.

Exclusion Criteria:

* patients less than 18 and older than 60.
* patients too ill (medically/phytologically) to consent.
* suicidal or homicidal patients.
Ultrasound Device for Hair Removal

The purpose of this study is to evaluate the safety and efficacy of the Cutera UHAIR ultrasound device for hair removal.

The purpose of this study is to evaluate the Cutera UHAIR device for safety and efficacy for removal and long term reduction of unwanted hair on subjects with Fitzpatrick skin types I-IV and dark (black or brown), red, and blonde colored hair.

At investigator's discretion, each subject will receive treatments and will be scheduled for follow-up visits after the final treatment. The treated area(s) will be photographed at each visit for analysis.

Eligibility Criteria:
Inclusion Criteria:

* Male or female at least 18 years of age
* Fitxpatrick skin type I-IV
* Area with unwanted hair
* Subject must be able to read, understand and sign the consent form
* Subject must adhere to the follow-up schedule and study instruction

Exclusion Criteria:

* Simultaneous participation in any other clinical study
* Inability or unwillingness to follow the treatment schedule
* Inability or unwillingness to sign the informed consent
* Infection in the target area
* Any disease or condition that could impair wound healing
* History of keloid formation
* History of malignant tumors in the target area
* Skin abnormalities in the target area, e.g. cuts, scrapes, wounds, scars, large moles
* History of hair removal in target area (light based or electrolysis)
* Pregnant or lactating
Use of a Diary to Assess and Monitor Behavioral and Psychological Symptoms of Dementia ( BPSDiary )

The goal of this randomized clinical trial is to compare the efficacy of the use of a diary to record behavioral and psychological symptoms of dementia (BPSD) in persons with dementia. The main questions it aims to answer are:

* Does the use of a diary lead to a reduction of the caregiver's burden at 3 months, compared with standard care?
* Does the use of a diary lead to a reduction of the neuropsychiatric inventory (NPI) score at 3 months, compared with standard care?
* Does the use of a diary result in less psychotropic drugs prescribed to the patient at 3 months compared with standard care?
* Are physicians and caregivers satisfied with managing patients with the use of a diary?
* Does the use of a diary reduce the caregiver's stress related to BPSD at 3 months, compared with standard care? Participants will be randomly assigned to either the use of a diary or a control group. Caregivers in the diary arm will be asked to fill in a diary with BPSD including triggers, severity, day and hour, to be analyzed by physicians to prescribe appropriate pharmacological or non-pharmacological interventions. The control group will receive usual care (i.e., appropriate interventions will be applied after interviewing the caregiver and/or visiting the patient).


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of cognitive impairment (neurodegenerative or vascular)
* Caregiver and patient willing to participate in the study
* Caregiver living with the patient or able to cover all 24 hours
* Presence of BPSD pertaining to the hyperactivity-irritability-impulsivity-disinhibition cluster (HIDA)
* Signed informed consent before the beginning of the study

Exclusion Criteria:

* Refusal to consent to participate in the study
Discovery and Validate of Multi-genetic Biomarkers for Capecitabine in Chinese Colorectal Patients

At present, chemotherapy is widely used in the adjuvant treatment of colorectal cancer patients after surgery. Capecitabine is one of the main chemotherapeutic drugs. But the effect is not good enough, the adverse reaction is serious, and the individual differences were significant. The present study shows that these problems are related to the differences in the exposure of capecitabine and its metabolites in different patients. The genetic biomarkers for capecitabine include DRD, MTHFR and TYMS. Mutations in these genes directly affect the expression of metabolic enzymes involved in capecitabine and control the concentration of capecitabine and its metabolites. However, these markers have been obtained through clinical trials in the United States, and their role in predicting the effectiveness or safety of capecitabine and its metabolites has not been validated in Chinese cancer patients.The study was based on a case study of patients with colorectal cancer in China, and capecitabine as the primary postoperative chemotherapy regimen to verify whether the available biomarkers can be used to predict the effectiveness and safety of capecitabine. To clarify the effect of capecitabine on endogenous metabolites, and to study the mechanism of its effect, so as to discover new biomarkers.


Eligibility Criteria:
Inclusion Criteria:

1. more than 18 years old;
2. patients with colon cancer diagnosed by biopsy (regardless of cancer stage);
3. received postoperative containing capecitabine chemotherapy;
4. volunteer to participate in the experiment

Exclusion Criteria:

1. pregnant and lactating women;
2. patients with hypersensitivity to fluorouracil or severe metabolic failure;
3. patients with severe infection;
4. patients with other cancers other than colorectal cancer within the first five years of colorectal cancer surgery;
Clinical Relevance of Different Training Intensities in Chronic Heart Failure.

To determine the efficacy of different aerobic exercise training intensities in patients with chronic heart failure.Forty five eligible male patients with chronic heart failure were randomly assigned into three groups( High intensity , moderate intensity and low intensity)groups .

Forty five eligible male patients with chronic heart failure secondary to ischemic heart disease were selected from National Heart Institute heart failure outpatient clinic , their ages ranged from 50-60 years old and their ejection fraction ranged from 30-40% ,they were randomly assigned into three groups :HIT Group: received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.(n=15) MIT Group: received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. .(n=15) LIT Group: received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months, Before and after intervention, the following measures were obtained: Echocardiograph parameter (EF%, and left ventricular internal dimension ) , prognostic biomarkers (proBNP), and quality of life .

Eligibility Criteria:
Inclusion Criteria:

* Patients with following criteria were included :

  * All patients ages were between 50 - 60 years old
  * Fractional shortening \< 25% and ejection fraction \< 40%
  * Sinus rhythm.
  * Heart Failure due to ischemic heart disease.
  * New York Heart Association (NYHA) class II-III.
  * Regular medical treatment.

Exclusion Criteria:

* Patients with following criteria were excluded :

  * Chronic heart failure due to other causes
  * History of pulmonary disease (chronic obstructive lung disease, moderate to severe pulmonary hypertension).
  * Recent acute coronary syndrome or revascularization (3 months).
  * Exercise limited by angina or peripheral arterial occlusive disease;
  * Cerebrovascular or musculoskeletal disease preventing exercise testing or training.
  * Poorly controlled or exercise-induced cardiac arrhythmias
  * Logistic problems to attend regular exercise training sessions. Uncontrolled hypertension.
Interactive Motivational Media for Perinatal Drug Abuse - 3

Interactive Motivational Media for Perinatal Drug Abuse

The goal of this exploratory/developmental proposal is to develop a low-cost, highly adaptable brief motivational intervention for perinatal drug abuse via embedding motivational principles in a self-contained interactive computer system. The Motivation Enhancement System (MES) will utilize a touch-screen, audio enhancement, and an interactive narrator to guide women in the immediate post-partum period through evaluation (thus facilitating self-report) and a one-time motivational intervention. A taxi voucher will be provided to further facilitate entry into treatment, and multiple tailored self-help mailings will be issued following discharge. If validated, this intervention could offer a highly cost-effective, replicable, and prescriptive method for increasing self-change and treatment involvement in drug abusers. Following development of the MES, a preliminary pilot phase will study the use of the MES with post-partum drug-using women and make necessary modifications, using data from participant debriefings and a single-case research design. After optimization of the MES, a clinical trial will randomly assign 120 post-partum drug-using women into treatment or assessment only conditions, with a 3-month blinded follow up to evaluate intervention effects on drug use and treatment involvement. Toxicological and self-report measures, as well as objective analysis of infant development, will be utilized. Participants will be lower socioeconomic status urban women.

Eligibility Criteria:
Woman in immediate postpartum period

Inclusion Criteria:

Screen positive for drug use (self-report)

Exclusion Criteria:

Frank psychosis or other cognitive impairment, fatigue, grief over medically compromised infant, inability to communicate in English
Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients

The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic inflammatory, systemic and auto-imune disorder affecting primarily the joints. In RA, inflammatory synovium causes destruction of cartilage, erosion of the adjacent bone and ultimately loss of function of the affected joint. Newer imaging techniques, such as ultrasound (US), have shown promise in evaluation of RA. Many US scoring system have been used to classify and quantify the synovium, effusion, erosion and cartilage for assessing and monitoring AR. However, its use is considered problematical because there are very few data on normal joints and, at this point, there is no clear definition of excess amount of synovium in normal people.

Eligibility Criteria:
Inclusion Criteria:

* no articular disease (healthy group)
* establish rheumatoid arthritis (RA group)

Exclusion Criteria:

* diabetes
* hypothyroidism- hemophilia
* pregnancy
* previous septic arthritis
* previous articular surgery
* symptomatic osteoarthritis
* no superimposed collagenoses (RA group)
Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Release for Advanced Solid Tumors

To study the safety and clinical effects of intratumor injecting CpG-ODN and in situ release of tumor antigen by interventional ablation or drug-eluting beads to treat advanced solid tumors.

1. Percutaneous microwave ablation or intratumor injection of drug-eluting beads to destroy cancer cells to release tumor-specific antigens
2. Intratumor injection of type A/C CpG-ODN with or without infusion of CAR-T cells secreting scFv against OX40
3. Assessing side effects and therapeutic efficacy after the combined treatments

Eligibility Criteria:
Inclusion Criteria:

* Solid advanced malignant tumors
* Age between18 and 80 years
* Life expectancy is greater than three months

Exclusion Criteria:

* Benign tumor
* Life expectancy is less than three months
* Serious medical comorbidity
* Others
Outcome of COVID-19 Cases Based on Tuberculin Test: Can Previous BCG Alter the Prognosis?

There is no evidence that the Bacille Calmette-Guérin vaccine (BCG) protects people against infection with COVID-19 virus. Two clinical trials addressing this question are underway, and WHO will evaluate the evidence when it is available. In the absence of evidence, WHO does not recommend BCG vaccination for the prevention of COVID-19. WHO continues to recommend neonatal BCG vaccination in countries or settings with a high incidence of tuberculosis. There is experimental evidence from both animal and human studies that the BCG vaccine has non-specific effects on the immune system. These effects have not been well characterized and their clinical relevance is unknown


Eligibility Criteria:
Inclusion Criteria:

* COVID-19 positive cases admitted to hospitals in Upper Egypt

Exclusion Criteria:

* None
Slump Physiotherapy : Effect on the physiologicAl Knee Extension Range-of-motion

Background: The neurodynamics technique seems interesting for increased lower limb flexibility of the lower limbs in healthy subjects. The objective of this study is to assess the physiological effects of the SLUMP sliding technique on the range of knee extension during the SLUMP test.

Methods: 60 physiotherapy students perform measurements during three tutorials. The first involves training in evaluation techniques. The second involves mobilizing the knee, out of the SLUMP position. The third tutorial includes neuronal mobilization in SLUMP.

Knee extension in SLUMP position is measured immediately after completing techniques. The mobilization amplitudes (degrees) will be compared between the techniques by a Student test on paired series, each subject being his own control.

Discussion: The results of this study will provide evidence for the physiological effect of SLUMP sliding techniques performed by physiotherapy students on the range of knee extension during the SLUMP test in asymptomatic subjects.


Eligibility Criteria:
Inclusion Criteria:

* Students enrolled in second year of physiotherapy training in Rouen's physiotherapy Institute, taking part to neurodynamic technique course unit (CU 7)
* Ability to perform daily physiotherapy techniques, assessed by an accredited doctor from regional health agency and a medical examination during the first year of scholarship (occupational medicine service of Rouen's University hospital)
* French commonly spoken and red
* Aged 18 or older
* Registered to the national care \& health system (Social security number)
* Willingness to take part to the study

Exclusion Criteria:

* Person denied of freedom by judicial or administrative decision
* Person requiring a guardian, guardianship or curators
* History of psychological disease/illness or sensorial disease preventing from understanding the recruitment conditions
Evaluation of Empagliflozin vs Standard Care in Veterans With Prediabetes

Prediabetes effects 96 million people 18 years of age or older. It is important to identify treatment options to slow or prevent progression to diabetes. It is also critical to assess the potential of medications like sodium glucose transporter 2 inhibitors to reduce the risk of cardiovascular events and kidney complications, both common and costly complications of diabetes. This is a 12-week, open-label pilot feasibility study assessing the use of empagliflozin in prediabetes.


Eligibility Criteria:
Inclusion Criteria:

Diagnosis of prediabetes defined by HbA1c \>5.7% and \<6.5% or fasting glucose 100-125 mg/dL with documentation of diagnosis (ICD-10 code) within electronic health record at time of enrollment

* Age 35 to 60 years at time of enrollment
* Able to read and speak English

Exclusion Criteria:

* Diagnosis of diabetes (type 2 or type 1)
* Contraindication to SGLT2i medication per medication labeling, prior adverse reaction to SGLT2i medication, or received SGLT2i medication within the 6 months prior to enrollment
* Currently prescribed an antihyperglycemic agent approved for treatment of type 2 diabetes or taking any FDA-approved weight loss agent or over-the-counter supplement promoted for weight loss
* Veterans unable to complete informed consent process (Veterans with impaired decision-making ability or who require use of a legally authorized representative)
* Women who are pregnant or may become pregnant
* Veterans with neurogenic bladder, indwelling catheter, or urinary tract infection within the previous 12 months requiring hospitalization or emergency department visit