cyrilzakka/clinical-trials huggingface dataset:
Echocardiographic Prediction of Fluid Responsiveness After a Mini-fluid Challenge in Non-ventilated Patients With Shock

The main objective of this study is to show that the variation of the subaortic velocity time integral after a mini test by filling 100 cc of normal saline over 1 minute (ΔITV100) is predictive of response to filling (defined as an increase in aortic velocity time integral measured by transthoracic ultrasound over 15% after administration of 500 cc of normal saline over 15 minutes) in non-ventilated shock patients.

The secondary objectives of this study include:

* To determine the sensitivity and specificity of the variation of the velocity time integral after administration of 100 cc of normal saline over 1 minute (ΔITV100) to predict the response to the filling.
* To study the inter-observer variation of ΔITV100 measurement.
* To compare ΔITV100 to other clinical and radiological parameters for predicting response to filling (initial value of the subaortic velocity time integral, variation in mitral E wave, E / A, respiratory variation of the diameter of the inferior vena cava, marbling clinical evolution score.

Eligibility Criteria:
Inclusion Criteria:

* The patient must have given his/her informed and signed consent
* The patient must be insured or beneficiary of a health insurance plan
* Systolic blood pressure (SBP) \< 90 mmHg
* Signs of inadequate cardiac output: urine output \<0.5 ml / kg / h for more than two hours, hyperlactataemia
* Requires amines to maintain an SBP ≥ 90 mmHg or inability to lower amines or requires an increase in amines

Exclusion Criteria:

* The patient is participating in another study
* The patient is in an exclusion period determined by a previous study
* The patient is under judicial protection, under tutorship or curatorship
* The patient (or his/her person-of-trust) refuses to sign the consent
* It is impossible to correctly inform the patient
* The patient is pregnant, parturient, or breastfeeding
* The patients has a contraindication for a treatment necessary for this study
* Cardiogenic shock
* Acute pulmonary edema
* Moribund patient
* Non echogenic patient
* Patient with cardiac arrhythmia
* Patients for whom the passive leg raising test is contraindicated (hyper intra-abdominal pressure, pelvic or lower limb trauma)
HygiRelief Procedure and HygiSample Evaluation for Functional Constipation

This study has a single center, prospective, open label design. The population will include patients diagnosed with Rome IV Functional Constipation who are at the time of study enrollment being managed with a stable dose of Linzess. They will stop taking their Linzess, undergo monitoring of bowel habits for 2 weeks, have a HygiRelief procedure and then undergo an additional 2 weeks of bowel habit monitoring.

After undergoing a 5-7 day Linzess washout period, patients will record their bowel habits in a daily diary for 2 weeks. Patients will have the HygiRelief procedure with a HygiSample evaluation, then they will record their bowel habits in a daily diary for 2 weeks following the HygiRelief procedure.

HygiSamples (stool samples) will be collected throughout the HygiRelief procedure and the samples will be sent for microbiome evaluation.

Patients will complete multiple questionnaires - Happiness Scale, Hospital Anxiety and Depression Scale (HADS), and a personal assessment which includes the Constipation Symptom Score and Adverse Event Screening. These will be completed at Baseline, after the 2 week PRE-HygiRelief period, and after the 2 week POST-HygiRelief period.

Eligibility Criteria:
Inclusion Criteria:

1. Patient's age is between 18 and 80 years old
2. Patient diagnosed with Rome IV Functional Constipation (Attachment C2)
3. Patient is currently managed with Linzess and willing to stop taking it for study duration

Exclusion Criteria:

1. Patient has functional bowel disorders characterized by alternating bowel habits (diarrhea/constipation)
2. Patient has any other condition that, in the opinion of the investigator, may adversely affect the compliance or safety of the patient or would limit the patient's ability to complete the study
3. Patient has any of the contraindications listed below:

   1. Cardiac: Congestive heart failure (NYHA class III or IV or EF \<50%)
   2. GI: Intestinal perforation, carcinoma of the rectum, fissures or fistula, severe hemorrhoids, abdominal hernia, recent colon, rectal, or abdominal surgery
   3. GU: Renal insufficiency (CC \< 60 ml/min/173m2), cirrhosis with ascites
   4. Abdominal surgery within the last 6 months
   5. Pregnancy
4. Patient took antibiotics within two months of starting the study
The Genetic and Affective Prediction Study

A major proportion of patients admitted to psychiatric acute and emergency departments have symptoms, behaviors or function influenced by implicit or explicit suicidal intention (tendency towards self-harm, or suicide attempt). There is an increased risk of suicide in the acute phase during in-patient stay and after discharge. At present there is no satisfactory tool to predict post-discharge suicide risk.

Multidimensional rating is expected to have better predictive properties than one-dimensional rating for suicidal behavior during in -patient stay and two years after discharge. Multidimensional rating assesses anxiety, panic, agitation, suicidal thoughts and ideations, as well as therapist's reactions during interviews. In the present study the predictive properties of two rating scales for suicidal behavior during in-patient stay and two years after will be compared. One of these is a multidimensional scale: "Multidimensional Assessment of Suicide Risk" (MARIS).


Eligibility Criteria:
Inclusion Criteria:

* acute agitated condition
* informed consent

Exclusion Criteria:

* Drug abuse
* in-patient stay for a fixed time at regular intervals
Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment

The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.

Limited data is available regarding the effects of various periodontal treatment protocols on GCF t-PA and PAI-1 levels, and the extent to which LLLT in conjunction with NSPT affects these levels in patients with Stage 3-4, Grade C periodontitis is unknown. Therefore, this study measured standard clinical outcomes and GCF t-PA and PAI-1 levels in patients with Stage 3-4 Grade, C periodontitis in order to assess the use of LLLT as an adjunct to standard NSPT.

This split-mouth study was conducted with 15 Stage 3-4, Grade C periodontitis patients and 15 healthy individuals matched for age and sex. Participants were grouped as follows: Periodontitis/NSPT (Sham); Periodontitis/NSPT+LLLT (LLLT); Periodontally Healthy (Control). LLLT was applied following NSPT and again on post-treatment Days 2 and 7. Clinical parameters were recorded at baseline (i.e. before NSPT) and on Day 30. Gingival crevicular fluid (GCF) samples were collected at baseline and during follow-up visits on Days 7, 14 and 30. GCF t-PA and PAI-1 levels were measured with ELISA.

Eligibility Criteria:
Inclusion Criteria:

* Stage 3-4, Grade C periodontitis (at least one site with probing depth (PD) and clinical attachment level (CAL) ≥5 mm in their incisors and/or first molars and at least 6 other teeth with similar PD and CAL measurements, with alveolar bone loss confirmed by radiography; familial aggregation;
* presence of ≥16 teeth;
* no periodontal treatment in the 6 months prior to data collection;
* non-smoker

Exclusion Criteria:

* systemic problems, including a medical history of cancer, rheumatoid arthritis, diabetes mellitus, or cardiovascular disease;
* compromised immune system;
* pregnancy, menopause, or lactation;
* ongoing drug therapy that might affect the clinical characteristics of periodontitis;
* use of systemic antimicrobials during the 6 weeks prior to data collection
SPRING - Assess the Clinical Care Pathway of Population With T2D and CKD in Four European Countries Using Real-world Data

This study is being carried out in 4 countries (France, Italy, Spain and the UK) to understand the clinical care pathway of population living with type 2 diabetes who also have evidence of chronic kidney disease.

The primary objective is to describe the population with T2D and CKD in terms of demography, clinical characteristics and medication use by CKD stage.


Eligibility Criteria:
Inclusion Criteria:

1. Adults (18 years old or older) diagnosed with T2D and treated with an antidiabetic medication before or at index date, set up on 1 January 2021
2. With evidence of Kidney damage before or at index date:

   1. diagnosed with CKD
   2. or with a record of eGFR below 60 ml/min/1.73 m\^2
   3. or with a record of uACR above 30 mg/g
3. Consulting a GP (all countries) or an Endocrinologist (France, Spain, Italy) or a Nephrologist (Spain) of the THIN® network.

Exclusion Criteria:

1. aged less than 18 years old at index date
2. less than 360 days prior index date
3. less than 360 days after index date
Registry Study to Evaluate the Clinical Outcome of Cancer Patients and Benign Diseases Treated with Radiation

Registry database repository for determining clinical outcomes primarily of patients who have received or have been evaluated for radiation treatment in either the definitive or palliative setting for both malignant and benign etiologies.

To compare the outcomes with National Cancer Data Base (NCDB) of the American College of Surgeon(ACS).

Investigator will retrospectively collect and evaluate information from patients with cancer or benign etiologies to improve future clinical outcomes and help identify prospective outcomes study questions. This information will include patients' name, medical record number, medical history, diagnosis, treatment, laboratory test results, diagnostic test results, pathology reports, therapeutic and nontherapeutic results, surgical results, radiology results, radiation therapy details (dose, techniques, toxicity), concurrent use of chemotherapy/systemic therapy, quality of life outcomes,cachexia status, and primarily last follow-up data. All information will be collected after their standard of care visits.

Eligibility Criteria:
Inclusion Criteria:

Any patient who received or was potentially evaluated for radiotherapy since 2000 for benign or malignant etiologies in the definitive or palliative setting.

Patients with comparatively similar diagnosis and disease status at UTSW, but electing not to undergo radiation therapy, treated with surgical or systemic therapy, or best supportive care, being followed by an oncology specialist at UT Southwestern Medical Center will also be eligible for evaluation. -

Exclusion Criteria:

None
the Prevalence of "Wearing-off" in Patients With Parkinson's Disease in Shanghai

The study would be designed as a multi-center cross-sectional investigation on the prevalence of Wearing-off in Parkinson's patients in Shanghai as well as related influencing factors.

PD patients would be randomly recruited into this investigation from around thirty hospital covering the 16 districts of Shanghai. The wearing off would be defined by two methods: the doctors' judgement or the WOQ-9 questionnaire which was a patient-determining tool. The investigation also includes the medicine, the severity of PD symptoms, the demographic factors. The study would be designed with the purpose of clarifying the prevalence of the "wearing-off" and its related influencing factors.

Eligibility Criteria:
Inclusion Criteria:

* have been clinical diagnosed with Parkinson's disease
* have received stable anti-Parkinson's treatment before being recruited to the study.

Exclusion Criteria:

* being suspicious of atypical Parkinson syndrome or secondary Parkinson syndromes
* have not received anti Parkinsonian treatment.
* being combined with serious cognitive dysfunction or psychiatric symptoms
* unable to complete the investigations.
Adjusting Challenge-Skill Balance to Improve the Elderly's Quality of Life

The purpose of this study was to clarify the effects on health-related QOL of occupational therapy involving the adjustment of challenge-skill balance in the activity of elderly clients.

This study was single-blind, randomized controlled trial. Clients were randomly assigned by blocked randomization (block size 4) to either the experimental group (occupational therapy that included assessment and adjustment of the challenge-skill balance of the activities) or to the control group (occupational therapy as normally conducted at the day care center). Randomization was stratified by sex and EuroQol visual analogue scale, resulting in four layers. The primary outcome was change in health-related quality of life after 10 sessions of occupational therapy. Clients were assessed before the intervention (pre-test) and after the 10th session (post-test). Significant differences were observed in the EuroQol-5 Dimension (EQ-5D) score and in the Medical Outcome Study 8-Item Short-Form Health Survey (SF-8) scores for general health, physical functioning , and vitality.

Eligibility Criteria:
Inclusion Criteria:

* age \>60 years
* occupational therapy at the center for \>3 months

Exclusion Criteria:

* dementia
* visual impairment
PAROMIP Pilot Study PAROdontites & MIcrobiota Periodontal

A new classification of periodontal diseases was created in 2018. the investigators want to know if this clinical classification is based, or not, on a biological reality. To do this, the investigators will collect data from the clinical examination (clinical assessment and radiological assessment) as well as non-invasive samples of subgingival plaque and crevicular gingival fluid (CGF). The subgingival plaque samples will be analyzed to define the microbiotic profiles of the patients and the CGF determined to define their inflammatory expression profiles. These results will then be linked to the diagnosis of severity of periodontitis.

In the new classification of periodontal disease, the investigators will seek to know whether there is a specific bacterial signature associated with the severity of damage on the one hand, and the other hand, the investigators will search for cytokinic biomarkers which can be correlated with the severity of the damage.

In this study, the investigators propose to include 25 patients with periodontitis stage I and II versus stage III and IV according to Chicago classification (2018)

Eligibility Criteria:
Inclusion Criteria:

* Men and women speaking and understanding French
* Aged over 18
* with generalized periodontitis (more than 30% of affected sites)
* Requiring non-surgical periodontal therapy
* with a minimum of 12 teeth (3 per quadrant), fitted or not
* Having given his oral consent to participate in the study
* Having given his written consent to participate in a biocollection

Exclusion Criteria:

* Less than 12 teeth present (3 teeth per quadrant)
* Presence of acute oral lesions (periodontal abscesses, endodontic abscesses, infectious or mycotic lesions...)
* Presence of ulcerative-necrotic gingivitis or periodontitis
* Presence of endo-periodontal lesions
* Chronic or systemic pathology or treatment that can influence the periodontal microbiota : immunotherapy, corticosteroid therapy, biotherapy, unbalanced diabetes, acute inflammatory rheumatism, neurological impairment...
* Antibiotic during the 3 month preceding inclusion
* Psychological or linguistic disability preventing good understanding of the study
* Minors
* Major patients under legal protection
* Patients deprived of their liberty
* Pregnant or lactating woman
* Patient not affiliated to a health insurance scheme
Association of Urinary Incontinence With Depression, Insomnia, Frailty and Falls in Older Adults

The aim of our study is to provide a holistic analysis of the geriatric syndromes associated with urinary incontinence, which can result in significant adverse outcomes in the elderly, and to explore the gender-specific relationships within these associations. The study revealed that urinary incontinence is highly prevalent among the older adults, particularly in women, and is associated strongly with depression, insomnia, frailty, and falls. Moreover, while older women with urinary incontinence exhibited more depressive symptoms than men, urinary incontinence was associated with similar frequencies of insomnia in both sexes. Considering the negative outcomes of depression, insomnia, frailty, and falls in older adults, as well as a decline in functionality, cognitive impairment, and prolonged hospitalizations and even mortality they cause, it becomes evident that urinary incontinence must be routinely assessed and treated by clinicians.


Eligibility Criteria:
Inclusion Criteria:

* The patients with comprehensive geriatric assessment data

Exclusion Criteria:

* dementia,
* those who experienced cerebrovascular occlusion with resulting neuromuscular paralysis
* active infections,
* schizoaffective disorder,
* epilepsy
* neuromuscular disorders
* those who were wheelchair or bed-bound,
* advanced chronic obstructive pulmonary disease (COPD)
* advanced chronic heart failure (CHF)
Study for Using Radiosurgery on Limited Metastases of Breast Cancer

The purpose of this study is to evaluate whether radiosurgery, along with standard chemotherapy, immunotherapy (the treatment of cancer by modulating the immune system and immune response), or hormonal therapy, affects the quality and length of life. The standard therapy is surgery, radiation therapy, or chemotherapy alone or in any combination. A second purpose of this study is to determine if the levels of a special type of protein (called cytokines) found in the blood are related to the quality of life while on this treatment.

Before treatment begins, you will have a physical exam and blood tests. Physical evaluations and blood tests will be done each week while you are receiving treatment, and at follow-up visits. You will be seen for follow-up evaluations 4 weeks after treatment is completed, and every three months thereafter. You will be asked to fill out a Quality of Life questionnaire, which should take 5-10 minutes to complete. This will be done prior to treatment and at your follow-up visits. You will receive high dose radiation therapy directed at the site of metastasis. This treatment will be given once a day, 5 times a week (Monday through Friday) for one to four weeks depending on the location and size of the disease to be treated.

Eligibility Criteria:
Inclusion Criteria:

* Age: no limit
* Karnofsky performance status (KPS) ≥ 70
* No more than 5 metastatic sites involving one or more different organs (liver, lung or bone).
* The size of the lesion must be such that it can be safely treated to sterilizing radiation doses according to the rules in the protocol.
* Previously treated lesions are not eligible unless the prescribed dose can be safely delivered.
* Concurrent therapy is allowed and recommended. The chemotherapy protocol type and schedule are at the discretion of the medical oncologist.
* Informed consent must be obtained.
* Pregnancy test must be negative for women of child bearing potential

Exclusion Criteria:

* Inability of patient to be followed longitudinally as specified by protocol.
* Technical inability to achieve required dose based on safe dose constraints required for radiosurgery.
* Women who are pregnant or nursing.
* Failure to meet requirements in Inclusion Criteria
* Contraindications to radiation.
Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer

Double bypass (hepaticojejunostomy + gastrojejunostomy) is compared to stent strategy in patients planned for curative pancreatic resection in whom peroperative findings makes resection impossible.


Eligibility Criteria:
Inclusion Criteria:

1. Preoperatively

   * Patients with stent treated tumor in the pancreatic head or periampullary planned for pancreaticoduodenectomy
   * The patient jaundice should have worn off and there should be no signs of duodenal obstruction
   * The patient has given informed consent after verbal and written information in accordance with approved ethics application
   * The patient has no anatomical conditions making endoscopic therapy impossible such as previous Billroth II or Gastric Bypass.
2. Intraoperatively

   * Peroperative findings of of carcinomatosis, metastases or local irresectability who oppose radical surgery
   * Surgical double bypass should be technically feasible
   * The patient has given informed consent after verbal and written information in accordance with approved ethics application

Exclusion Criteria:

* Peroperative signs of dysfunction on biliary stent
* Peroperative findings of gastric outlet obstruction
* Surgical double bypass not technically feasible
Evaluation of a Preoperative Education Class for Colorectal Surgery Patients

The purpose of the study is to evaluate the value and effectiveness of a newly-implemented preoperative education class for patients undergoing colorectal surgery.

This is a non-randomized study to be conducted in a cohort of patients who are scheduled to undergo colorectal surgical procedures at Carolinas Medical Center (CMC)-Main. The primary objective of this study is to determine the effect of preoperative education classes on postoperative compliance with mobilization guidelines. Secondary objectives of this study are to evaluate the effect of the preoperative education class on patient knowledge, anxiety, and satisfaction, and postoperative outcomes such as inpatient length of stay, postoperative complications, and 30-day readmission rates. Data will be compared between patients who are scheduled to attend the class and attend and those who are scheduled to attend the class and do not.

Eligibility Criteria:
Inclusion Criteria:

* Scheduled to undergo surgical operations of the colon or rectum at Carolinas Medical Center Main

Exclusion Criteria:

* A medical condition, laboratory finding, or physical exam finding that precludes participation
* Develop a significant intra- or postoperative complication that precludes or delays participation for longer than 4 weeks; or
* Have anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.