cyrilzakka/clinical-trials huggingface dataset:
Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

This study investigates the psychophysiological correlations of aggression and response to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD). Data was gathered about participants' level of aggression through the Reactive-Proactive Aggression Questionnaire (RPQ). The stimuli that were presented to the participants included 1) a loud sound, 2) threatening photographs from the International Affective Picture System (IAPS), and 3) the Trier Social Stress Task (TSST). Participants' psychophysiological features of heart rate and galvanic skin conductance were measured and analyzed in relation to their RPQ scores and clinical diagnosis.


Eligibility Criteria:
Inclusion Criteria:

1. Subjects between ages 7 and 16 years
2. Subjects who fulfil all criteria for a DSM-IV diagnosis of ADHD, conduct disorder, or oppositional defiant disorder
3. Subjects with willingness to participate in a randomized, double-blind controlled trial
4. Subjects with complete written, informed parental consent and child assent
5. Subjects with IQ of 70 or more

Exclusion Criteria:

1. Subjects who have IQ in the below 70
2. Subjects who are younger than 7 years old or older than 16 years old
3. Those without written parental consent
4. Those with brain pathology such as serious head injury, epilepsy, etc.
The Long-term Value of Preoperative Duplex Before Surgery for Varicose Veins

Duplex imaging is costly and time-consuming, but is used increasingly for preoperative evaluation of varicose veins. Its value in terms of the long-term results of surgery is not clear. 293 patients (343 limbs) with primary varicose veins were randomized to operation with or without preoperative duplex imaging. Reoperation rates, clinical and duplex findings were compared at 2 months and 2 years after surgery. Routine preoperative duplex examination led to an improvement in results. However two years is a short time, and with a longer follow-up other mechanisms for recurrence may become more important, e.g. neovascularization (new vessel formation) or progression of disease, hence the value of a detailed preoperative diagnosis may be diminished. The aim of this phase of the investigation is to study the results after 8 years, in particular what mechanisms for recurrences were most important.


Eligibility Criteria:
Inclusion Criteria:

* patients with primary varicose veins

Exclusion Criteria:

* pure cosmetic complaints
* previous venous surgery or sclerotherapy
* history of suspect or manifest deep venous thrombosis
* active or healed venous ulceration
* peripheral arterial disease
* previous significant trauma to the leg
* general illness
* alcohol or drug abuse
* unable to understand information
STOP? II: Testing of a Toolbox for Structured Communication in the Operating Room

The purpose of the study is to test the impact of the StOP?-protocol - an intra-operative communication briefing, on post-operative mortality and important patient outcomes.

The StOP?-protocol is a communication briefing initiated by the responsible surgeon during a surgical operation. The surgeon informs the team present in the operating room about the current Status of the operation, the Objectives of the next steps and the potential Problems the surgical team may meet; the responsible surgeon encourages the team to voice any question or concern (?).

To test the impact of the StOP?-protocol on patient outcomes, the study is designed as a randomized controlled trial. Surgeons will be randomized either (a) in the intervention group and be trained to perform the StOP?-protocol or (b) in the control group and will communicate as they prefer during their operations. Post-operative patient outcomes of the surgeons in the intervention and the control group will be compared to evaluate the effects of the StOP?-protocol.

Eligibility Criteria:
For the clusters (surgeons)

Inclusion Criteria:

* Board-certified surgeons with specialization in one of the following disciplines: general, visceral, thoracic, vascular surgery, surgical urology, or gynecology.

Exclusion Criteria:

* Surgeons who are already performing StOP?-protocol. (Potentially, surgeons who took part in the first study (StOP-I) may still perform StOP?).
* Surgeon who were previously enrolled in the StOP?-II trial (this is relevant for surgeons who move or rotate between departments/hospitals and might therefore be working at different participating sites).

For the patients:

Inclusion criteria:

* Patients operated by cluster surgeons during the cluster-specific time period
* General consent from the patients, allowing the use of healthcare-related data that are the result of the patient's treatment. In case no written document from the general consent is available despite documented efforts of the participating center, article 34 HRA (Swiss law) will be applied, allowing the use of the healthcare-related patient data.

Exclusion criteria:

* Patient age below 18 years
* Previous operation at the same site up to 30 days prior the index operation
* Procedures not done in operating rooms but in outpatient clinics, on wards, etc.
* Mainly diagnostic endoscopic procedures (e.g. colonoscopy, gastroscopy, bronchoscopy)
* Percutaneous interventions (e.g., transurethral interventions)
* Documented refusal for the use of healthcare related data
Exposure Measurements and Interventions for Aerosol Produced by Gastrointestinal Endoscopy

Study objective: To clarify the risk of exposure to the exhaled aerosol droplets from patients for medical staffs during digestive endoscopy via labelling the oral mucosa with vitamin B2 solution, and evaluate the protective efficacy of personal protective equipment.

Study design: This is a prospective randomized controlled study.

This is a prospective randomized controlled study. Patients who meet the inclusion criteria and do not meet the exclusion criteria are recruited for this trial. They will be randomly divided into the control group and the intervention group (A total of 70 subjects, and 35 per group based on calculation of sample size). The in vitro bionic model next to the doctor simulated a medical staff, which is printed via the stereolithographic appearance 3D printing technique following the morphological structure data of human face and airway obtained by processing CT images, will either wear a mask or not, depending on the intervention group (in the intervention group, in vitro model wears personal protective equipment). Before starting the esophagogastroduodenoscopy (EGD) under anesthesia, vitamin B2 saline solution (vitamin B2 dosage determined by the suggested daily nutrient uptake in China) is dripped in their mouths. When the examination is finished, the dosage of facial mucosa deposition and airway inhalation of the in vitro model is quantified as a cumulative droplet mass (μg) over all the exposure time. The deposited droplets are collected by wiping method, and the inhaled droplets are sampled by a solution-based sampler (SKC, U.S.A.). The dosage is detected by the Fluoro Max-4® fluorophotometer (HORIBA, Japan). By comparing and analyzing the results of the two intervention groups, the researchers try to evaluate the risk of exposure under the personal protective equipment and assess the effectiveness of it.

Eligibility Criteria:
Inclusion Criteria:

* During the study period, patients who were treated in the digestive endoscopy center of Peking Union Medical College Hospital and planned to undergo digestive endoscopy. Age and gender are not limited temporarily.

Exclusion Criteria:

* Patients who have ever been allergic to the medical non-toxic fluorescent agent ( vitamin B2 saline solution).
* Patients who received anti-tumor therapy during the period of digestive endoscopy.
* Patients with poor general conditions, including severe cardiopulmonary diseases, coagulation disorders, or a total of platelet less than 50\*10\^9/L.
* Patients with structural pulmonary disease (chronic obstructive pulmonary disease, asthma, etc.) or airway/pulmonary surgery history
* Patients with intolerance or contraindications to digestive endoscopy.
Prevention of Preterm Birth With a Pessary in Twin Gestations

Preterm birth (PTB) is a major health problem and contributes to more than 50% of the overall perinatal mortality. Twins are at increased risk for PTB. The number of twins births has risen substantially due to the increased use of assisted reproductive technology. The rate of twin births in the United States rose from 18.9 to 32.2 per 100 live births between 1980 and 2004. The increased rate of PTB in twins is associated with increased morbidity and mortality rates. Almost one in four very low birth-weight infants (below 1500 g) born in the United States are twins, as are one in six infants who die in the first month of life. Cervical shortening is a risk factor for PTB. Transvaginal ultrasound measurement of cervical length is a reliable screening test for prediction of PTB. There is currently no effective treatment to decrease the incidence of PTB in women with twin gestations, but there is some evidence that the use of a cervical pessary in women with a short cervix has promise. If effective this approach would be particularly appealing because of the wide availability of pessaries, ease of use, and low cost. Unfortunately, existing studies are inadequate to confirm effectiveness; a well designed, properly powered, prospective randomized trial is warranted prior to widespread implementation in clinical practice. We propose such a trial to study the effectiveness of the pessary in decreasing the incidence of PTB in an inner city Philadelphia population.


Eligibility Criteria:
Inclusion Criteria:

* 18-50 years of age
* Twin pregnancy (limits the participants to female gender)
* Short cervical length (less than or equal to 30 mm) on second trimester ultrasound at 18-27 6/7 weeks gestation

Exclusion Criteria:

* Singleton or higher order than twins multiple gestation
* Monoamniotic twins
* Twin twin transfusion syndrome
* Ruptured membranes
* Lethal fetal structural anomaly
* Fetal chromosomal abnormality
* Cerclage in place (or planned placement)
* Vaginal bleeding
* Suspicion of chorioamnionitis
* Ballooning of membranes outside the cervix into the vagina
* Painful regular uterine contractions
* Labor
* Placenta previa
Hand Lateralization by Using EEG Analysis Method in Amputees

Studies on the improvement of body image or body perception have proven their effectiveness in different clinical situations such as pain management and chronic pain treatment. The aim of this study is to evaluate the hand lateralization cognitive task by recording Electroencephalography (EEG) signals from different personal perspectives in amputees. In this study, the paradigm in which personal perspectives are evaluated over the hand lateralization task will be applied to amputees and healthy volunteer participants. Data will be recorded via EEG and Eprime software program.

The aim of this study is to evaluate the hand lateralization cognitive task by recording Electroencephalography (EEG) signals from different personal perspectives in amputees.

In this study, the paradigm in which personal perspectives are evaluated over the hand lateralization task will be applied to amputees and healthy volunteer participants.

It was planned to enroll two groups to the study. One group is named "amputees" the other one is "control". Control group will be matched in terms of age and gender with the amputees group. Before hand lateralization test, participants will be evaluated regarding eligible criterias and EEG paradigm regarding hand lateralization will be performed for each participant.

Both groups (Amputees and Control) will complete "hand lateralization program" for at least 10 days. The test will be sent each day on an online system. Participants' performances will be recorded via online system.

Following 10-day period, EEG paradigm regarding hand lateralization will be performed for each participant, again.

Before and after comparisons will be analyzed. Data will be recorded via EEG and Eprime software program.

EEG-Event Related Oscillation (power spectrum, phase locking) analysis will be performed for each frequency bands: alpha, theta, beta, gamma.

Eprime analysis will be performed for the data of reaction time and accuracy rate.

Eligibility Criteria:
Control group:

Inclusion Criteria:

* being between ages 18-65,
* consenting,
* with no limitation in mobility or movement disorder,
* A score of 21 or higher on the Montreal Cognitive Assessment Test

Exclusion Criteria:

* refuse to attend to the study,
* Having any mental, neurological or musculoskeletal problems,
* Inability to perform activities that require long-term attention,
* Inability to detect given commands,
* Using sedative drugs and/or derivatives

Amputee group:

Inclusion Criteria:

* between ages 18-65,
* using prosthesis,
* A score of 21 or higher on the Montreal Cognitive Assessment Test

Exclusion Criteria:

* Having phantom pain,
* Having open wound on stump,
* Having any discomfort feeling on stump,
* Having any mental, neurological or musculoskeletal problems,
* Inability to perform activities that require long-term attention,
* Inability to detect given commands,
* Using sedative drugs and/or derivatives
A CCTA Guided Management Strategy Versus a Standard of Care Strategy in Type 2 NSTEMI

This study design is a prospective randomized control trial to compare outcomes between the utilization of coronary computed tomography angiography (CCTA) vs conservative treatment in type 2 NSTEMI. The targeted population is expectedly heterogeneous and inpatient setting who are admitted and diagnosed with type 2 NSTEMI.

This study design is a prospective randomized control trial to compare outcomes between the utilization of coronary computed tomography angiography (CCTA) vs conservative treatment in type 2 NSTEMI. The targeted population is expectedly heterogeneous and inpatient setting who are admitted and diagnosed with type 2 NSTEMI. Patients are randomized into 2 groups. Group 1 undergoes coronary 64-detector row computed tomography angiography (CCTA) and Group 2 receives conservative management and treatment for underlying conditions. The investigators will evaluate cross-sectional and time-varying clinical, laboratory, and imaging characteristics in association with clinical events. The exclusion criteria are an absence of information for follow-up of clinical events, and patients who have absolute and relative contraindications for CCTA. Absolute contraindications are a patient history of severe or anaphylactic reaction to iodinated contrast, inability to cooperate with scan protocols, hemodynamic instability, decompensated heart failure, acute myocardial infarction, and renal impairment with GFR \< 30. Relative contraindications include pregnancy, inability to tolerate heart rate-slowing medications or nitroglycerin, recent phosphodiesterase inhibitor use, severe aortic stenosis, bronchospastic disease, and patient's weight and height.

Eligibility Criteria:
Inclusion Criteria:

* Inpatient with type 2 NSTEMI
* Aged 18-70 years old
* At the University of Louisville and Jewish hospitals

Exclusion Criteria:

* History of severe or anaphylactic reaction to iodinated contrast
* Inability to cooperate with scan protocols
* Hemodynamic instability
* Decompensated heart failure
* Acute myocardial infarction
* Renal impairment with GFR \< 30
* Pregnancy
* Inability to tolerate heart rate-slowing medications or nitroglycerin
* Recent phosphodiesterase inhibitor use
* Severe aortic stenosis
* Bronchospastic disease
* Patient's weight and height
Hepatocellular Carcinoma Registry for Turkey (3K Trial)

This registry study is national, multi-center, prospective study without any interventions to the treatment strategies and/or decisions of the investigators. It is designed in order to determine the general profile of HCC patients in Turkey. Socio-demographic characteristics, family history, medical history and treatment pattern of HCC patients will be evaluated.


Eligibility Criteria:
Inclusion Criteria:

* To be diagnosed with hepatocellular carcinoma in last 3 months
* To be older than 18 years old
* To sign informed consent form (ICF)

Exclusion Criteria:

* Patients that does not sign or withdraw informed consent form.
* According to investigator's opinion; existence of any situation/condition that will significantly complicate patient follow up.
* Currently or previously taking part in 3K observational study
Receptive Music Therapy on Anxiety and Vital Parameters in Hospitalized Covid-19 Patients.

Hospitalized patients for Covid-19 are extremely isolated from their families for a long and uncertain period of time .This traumatic separation makes patients vulnerable to different degrees of stress disorders as well as depression and anxiety , fear of the unknown and dying, sleeplessness, agitation, discomfort, pain, immobility, frustration and inability to relax .

MusicTtherapy has been shown to play a valuable role in the care of patients with serious illness, helping to address physical symptoms and psychological distress .

The aim of this study was to evaluate the feasibility of introducing Music therapy (MT) on site with Covid-19 patients as a supporting complementary/non-pharmacological intervention, to investigate the immediate effects a single MT session has on anxiety, heart rate (HR), oxygen saturation (O2Sat) and satisfaction compared to standard care.

In order to verify the hypotheses of the study, an RCT (mixed-methods approach pre -post design) will be carried out on patients diagnosed with SARS-COV2 admitted to Covid Hospital Bari, randomized into two groups: control group (B) and treatment group (A). .

The study starts on 15th April 2021 and it is expected to run for 1 mounth (15th May 2021).

The study is funding by University of Bari.


Eligibility Criteria:
Inclusion Criteria:

* age over 18 years
* not severe neurological or psychiatric conditions
* not hearing impairment
* not intubated

Exclusion Criteria:

* age under 18 years
* severe neurological or psychiatric conditions
* hearing impairment
* intubated
Treatment of Neck Pain With Transcranial Direct Current Stimulation

This study aim to investigate the effects of Transcranial Direct Current Stimulation for improving pressure pain thresholds (PPTs), range of motion,Neck Disability Index, the multidimensional health related quality of life (SF-12) and the multidimensional health related quality of life and pain in patients with mechanical neck pain (NP).

Fifty-four participants with NP will randomly allocated to either an Transcranial Direct Current Stimulation (ten sessions) or transcutaneous electric nerve stimulation (TENS) (ten sessions) during two weeks. . Visual Analogue Scale (VAS), Neck Disability Index ( NDI), range of motion and (CROM), Questionnaire SF-12 and PPTs in sub-occipital and upper trapezius muscles were measured at baseline, at the end of treatment and at 1 month follow-up. T-tests and a repeated-measures multivariate analysis of variance (RM-MANOVA) were used for VAS, CROM and PPTs, respectively.

Eligibility Criteria:
Inclusion Criteria:

* Patients of both sexes,
* Aged between 18 and 60 years, in an
* Active state of pain and diagnosed with a month of evolution.

Exclusion Criteria:

- Patients who are pregnant, have pacemaker and those Surgically operated cervical spine - Patients who have been treated with Transcranial Direct Current Stimulation a month earlier.
Effects of "Music for the Mind" on Pre-operative Anxiety in Dentistry

To examine the pre-operative effect of music for the mind compared to some other styles of music in patients undergoing dental procedures.

120 patients were sequentially assigned to four groups of 30 subjects. the music groups received Music for the mind, Iranian traditional music and Mozart music through headphone for ten minutes prior to dental procedures, and the control group received silence through headphone. anxiety score and pulse rate and blood pressure were measured before and after receiving music

Eligibility Criteria:
Inclusion Criteria:

* need for dental treatments

Exclusion Criteria:

* usage of anxiety drugs
* usage of psychoactive drugs
* emergency cases
Outcome of Kasai Portoenterostomy in Biliary Atresia in Upper Egypt

Kasai portoenterostomy is the key standard operation for biliary atresia. The aim of the study is to evaluate the short-term outcome of Kasai portoenterostomy for biliary atresia infants in Upper Egypt.

It is a cross-sectional retrospective multicenter study from Upper Egypt. The data will collected from the medical records of three university hospitals in Upper Egypt from January 2019 to December 2019.

Inclusion and exclusion criteria

Inclusion criteria included all neonates diagnosed with biliary atresia in the previous period and managed by Kasai portoenterostomy.

Exclusion criteria were neonates without a confirmed diagnosis of biliary atresia.

Eligibility Criteria:
Inclusion Criteria:

* all neonates diagnosed with biliary atresia in the previous period and managed by Kasai portoenterostomy.

Exclusion Criteria:

* Exclusion criteria were neonates without a confirmed diagnosis of biliary atresia.
Home and School Visits Intervention for Children With DM TYPE 1

Home and school visits by multidisciplinary team will improve metabolic control in kids having insulin dependent diabetes mellitus


Eligibility Criteria:
Inclusion Criteria:

* HbA1c ≥ 8% at baseline, and diabetes duration of at least 7 months.

Exclusion Criteria:

* Patients during honeymoon period
* Patients and their parents who do not speak Hebrew or Arabic
* Patients who were not under any educational system
* Patients who had other severe chronic disorders
Leptin Levels in Papillary Thyroid Cancer

The purpose of this study is to evaluate Leptin levels in females, in the setting of papillary thyroid cancer, benign thyroid nodules, and in normal females without thyroid disease.

There will be three groups in this study, but 2 of the groups are part of another study so will only recruit normal controls.

Eligibility Criteria:
Inclusion Criteria:

* Female
* Age\>/- 19
* Not currently pregnant or lactating
* Normal thyroid gland by history

Exclusion Criteria:

* Male Gender
* Pregnancy
* Lactation
* Age below 19
* Abnormal thyroid gland by history
* Abnormal thyroid gland by structure using ultrasound
* Abnormal thyroid gland by function using TSH, Free T4