cyrilzakka/clinical-trials huggingface dataset:
Sex Differences, Cognitive Training & Emotion Processing

This pilot project addresses two understudied questions related to neurocognitive deficits observed in treatment-seeking alcoholics. First, whether cognitive training improves performance and outcomes in alcoholics, and whether men and women differ in their response to this training. The second is whether directed training using affective materials (e.g., emotional faces) is differentially effective compared to that using traditional (i.e., neutral) stimuli.

This pilot project leverages the team's expertise in neurobehavioral assessment and focus on sex differences to examine the potential efficacy of cognitive training in treatment-seeking men and women with alcohol use disorders (AUDs). Specifically, the ask whether cognitive training interventions derived from current methods and conceptual models has differential benefits for treatment-seeking women vs. men. Although neurocognitive improvement during training is desired, of practical import is whether gains achieved transfer to other tasks and settings. Therefore, transfer of gains to tasks/domains varying in their similarity to training are assessed. Given noted sex differences in emotional processing and the purported role of emotional factors in women's substance use, training engaging emotional processing via the use of affective stimuli (faces and words) is included, predicting that women may differentially benefit from such training. Equal numbers of treatment-seeking men and women with AUDs will be randomly assigned to one of two active training interventions (neutral or affective stimuli). To control for abstinence-related recovery, a third group of participants, meeting identical selection criteria, will complete pre and post-intervention testing, but will not undergo the training intervention. Ss will complete baseline, 3 wks training (for active groups) and post-intervention testing and will be contacted monthly for 3 months after discharge.

Eligibility Criteria:
Inclusion Criteria:

* Minimum of 10 years of education
* Subjects must have 20/40 or better corrected vision (determined by Snellen chart)
* have no significant hearing impairment as determined by self-report and audiometric testing
* must meet criteria for DSM-IV alcohol dependence using the computerized Diagnostic Interview Schedule - IV
* A craving index is also administered to allow discussion in terms of DSM 5 classification.
* Comorbid substance use including nicotine use is not exclusionary.

Exclusion Criteria:

* May not have medical or psychiatric histories which would confound participation or data interpretation, e.g., epilepsy, stroke, untreated hypertension, psychotic disorders, anxiolytic medications.
* not be color blind (as determined by psuedoisochromatic plates)
* Endorsement of suicidal intent
Trial of Robotic Versus Laparoscopic-assisted Radical Resection for Rectal Cancer

This study compared robot-assisted total mesorectal excision (RTME) and laparoscopic total mesorectal excision (LTME) with regard to urinary function, sexual function and sphincter- preservation outcomes for low rectal cancer.

Urinary and sexual dysfunction are recognized complications of rectal cancer surgery in men. This study compared robot-assisted total mesorectal excision (RTME) and laparoscopic total mesorectal excision(LTME) with regard to these functional outcomes.Sphincter- preservation outcomes for low rectal cancer was observed as well.

Eligibility Criteria:
Inclusion Criteria:

* 1. Patients who are acceptable to two surgical procedures for the robot- assisted or laparoscopy-assisted rectal cancer, are willing to randomized trial;
* 2. Matching the diagnostic criteria;
* 3. Aged 18-70 years old;
* 4. Preoperative TNM staging (CT, laparoscopic exploration): cT1-3N0-3M0 (excluding M1, T4);
* 5. Preoperative ASA 3 scores;
* 6. There was no history of malignancy, no other malignant tumors by preoperative examination;
* 7. Without undergoing definitive treatment, such as radiotherapy, chemotherapy or immunotherapy preoperatively;
* 8. The informed consent form was signed by the patient himself(herself)or his principal agent;
* 9. In accordance with the international erectile function questionnaire (IIEF) urinary function scale, The urinary sexual function are normal.

Exclusion Criteria:

* 1. Age less than 18 years old or more than 70 years old;
* 2. Previous psychiatric patients or patients refused to sign the informed consent;
* 3. Attending other related clinical studies on surgical treatment of rectal cancer;
* 4. The patient has a history of malignant tumor, or a combination of other malignant tumors;
* 5. Patients have been treated with definitive treatment: radiotherapy, chemotherapy or immunotherapy;
* 6. Patients had received otherper abdominal operations (except for laparoscopic cholecystectomy);
* 7. ASA \>3;
* 8. Laparoscopic surgical contraindications: such as severe heart lung disease; abdominal wall hernia; diaphragmatic hernia; coagulation disorder; portal hypertension; pregnancy, etc.;
* 9. Those who has been confirmed to be unable to do a radical resection (T4 stage) for local advanced tumor;
* 10. Those who have urination sexual dysfunction preoperatively.
Rare Subtypes of Gastrointestinal Cancers

A single-arm prospective observational translational study of biomarkers in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal Tract.

In this study, the investigators seek to investigate biological aspects in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal.

The targeted treatment will be given as per standard of care. Translational blood samples will be drawn pre-treatment, before the third cycle of chemotherapy, and hereafter corresponding to the planned imaging during treatment and follow up.

The total cell free DNA will be quantified in all samples. The samples will be analyzed for tumor specific mutations such as the KRAS, BRAF, and NRAS oncogenes, by ddPCR. Circulating tumor DNA will also be identified by hypermethylation markers, and a focused panel of next generation sequencing can be applied. The samples will also be analyzed for immune-related biomarkers.

The investigators expect to include up to 130 patients.

This is a purely observational translational study. Results will be analysed in relation to outcome data.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of a rare subtype of GI cancer including BRAF V600E mutation, MSI-H, HER2 and others
* Diagnosis of cancer of the gastrointestinal tract may be made by histo- or cyto-pathology, or by clinical and imaging criteria
* Planned for targeted treatment
* Age 18 years or older
* Able to understand written information
* Consent to samples for translational research

Exclusion Criteria:

* Conditions precluding translational blood sampling
* Another concomitant cancer
Evaluation of the Measurement of Cardiac Output by the NEXFIN HD Monitor in Peroperative

Continuous perioperative cardiac output (DC) and blood pressure (PA) monitoring contributes to hemodynamic stability and ensures adequate perfusion pressure, resulting in a reduction in morbidity and mortality and length of hospital stay.

The monitors usually used in perioperative are either semi-invasive and difficult for calibration (oesophageal Doppler) or invasive (arterial catheter).

The Nexfin HD allows these two measurements and it is completely non-invasive, remains to validate its use in peroperative.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients candidate for surgery under general anesthesia requiring oesophageal Doppler or arterial catheter hemodynamic monitoring.

Exclusion Criteria:

* Patients with cardiac and thoracic surgery,
* patients for whom access to the head is impossible,
* facial trauma patients,
* patients with aortic malformation, dilation or coarctation,
* patients with aortic dissection,
* patients with vascular surgery with aortic clamping,
* patients with a tumor, stenosis or varices of the esophagus,
* patients with severe oesophagitis,
* patients with thoracic radiotherapy
* patients under guardianship or curatorship or deprived of liberty.
Treatment and Outcomes of Atrial Fibrillation and Acute Coronary Syndrome in Sweden

Many people who suffer from irregular heartbeats (atrial fibrillation) which might cause stroke, need to take blood thinners to prevent it. However, people with atrial fibrillation are also at increased risk of acute myocardial infarction or unstable angina pectoris (another heart condition marked by a chest pain, comprising so-called acute coronary syndrome for which another type of treatment that prevents blood from clotting (antiplatelet treatment) is indicated. In particularly if such patients undergo percutaneous coronary intervention, a procedure aimed to open up diseased blood vessels and hence to treat acute coronary syndrome, this treatment is needed. If a patients takes several anti-clotting blood drugs, the risk of bleeding is high. The number of possible drug combinations and treatment durations is large. This study will help us to understand which anti-clotting drug combinations are prescribed in real life among patients with atrial fibrillation and acute coronary syndrome, how effective and safe they are for patients. The study will look into the data that are already available in several very large Swedish databases which contain information needed for the research.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of ACS defined by a hospital discharge (ICD-10 code of I21 for myocardial infarction or I20.0 for unstable angina pectoris (with or without sub-codes) during the study period and a diagnosis of AF (ICD-10 code I48 with or without sub-codes) in the Patient Register before or on the same day as the patient was discharged for ACS.

Exclusion Criteria:

- No exclusions will be made as the registries capture the entire life-time of entire population of Sweden.
The Relationship Between Sense of Coherence and Wound Healing.

The study aimed to investigate the relationship between sence of coherence (SOC) and surgery-related oral wound healing.

The study was consisted of one hundred and sixty patients of both sexes (female,male) who were scheduled for oral surgery. Pre-operatively the patients were asked to complete a questionnaire designed to measure their Sense of Coherence (SOC). The wound healing was evaluated after 4 days, 14 days and 6 weeks after surgical operation. The results were analyzed statistically.

Many factors play a role in wound healing (WH) including physiologic factors. The concept of Sense of Coherence (SOC), reflects an individual's capacity to respond to stressful situations. High SOC scores indicate a strong SOC, and individuals with strong SOC are reported to tolerate stress better. Additionally, a strong SOC has been associated with fewer symptoms and significantly fewer issues related to oral condition. The aim of this study is to evaluate the relationship between SOC and wound healing following oral surgery. The study included 160 patients of both sexes (female,male). An informed consent form was obtained from all participants. Pre-operatively the patients were asked to complete a questionnaire designed to measure their Sense of Coherence (SOC). A blinded operator, who was not involved in the operation, recorded all data of the patients pre-operatively. All patients were undergone oral surgery. All surgical procedures were performed by the second maxillofacial surgeon. The first blinded operatoand conducted postoperative measurements. The wound healing was evaluated after 4 days, 14 days and 6 weeks after surgical operation. To evaluate of wound healing, a scale named Inflammatory Proliferative Remodeling (IPR) Scale was used. According to this scale, patients were recalled 3 days, 14 days and 6 weeks after surgical operation. The third blinded researcher was responsible for the analysis data.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients aged between 18-65 years
* Patients classified as American Society of Anesthesiologists (ASA) physical status ASA I
* Patients scheduled to undergo oral surgery

Exclusion Criteria:

* Not consenting to participate
* Intake of steroid, bisphosphonate or immune-suppressive medication
* Receiving radiotherapy in the head and neck area
* Pregnancy
* Inability to self-evaluate, and inability to communicate verbally and in writing.
Comparative Study on the Efficacy and Safety of Ondansetron Oral Membrane for the Prevention of Vomiting During Moderate Hypoemetic Chemotherapy

Children aged 4-15 years scheduled to receive Moderate or low emetic chemotherapy were randomly assigned to arm-A (Ondansetron mouth soluble film) or arm-B (Ondansetron tablet). Children recruited to arm-A received ondansetron mouth soluble film plus dexamethasone. Children recruited to arm-B received Ondansetron tablet plus dexamethasone. Ondansetron and dexamethasone were given continuously until 48hours after completion of chemotherapy. The primary end point of the study was to determine the proportion of patients who achieved a CR, defined as no vomiting, no retching, and no use of rescue medication, the proportion of patients who achieved a CR during the acute phase (0-24 hours) after administration of the last dose of chemotherapy. Secondary end points were the proportion of patients who achieved a CR during the 24-120 hours (delayed phase) and overall after administration of the last dose of chemotherapy


Eligibility Criteria:
Inclusion Criteria:

* Patients aged 4 to 15 years who have been diagnosed with malignant tumor through pathological examination and need to receive chemotherapy, gender is not limited;
* Receive moderate and low grade emetic chemotherapy;
* Patients with a score greater than 60 or higher have a life expectancy greater than 3 months;
* The patients were enrolled voluntarily, and the family members signed the informed consent, and the family members had good compliance and accurately recorded the vomiting diary.

Exclusion Criteria:

* Children allergic to 5HT3 antagonists;
* Active infection;
* Abnormal bone marrow function (absolute neutrophil count \<1000/mm3 platelet count \<100000/mm3);
* Abnormal renal function in serum creatinine beyond the upper age limit of normal (ULN);
* Abnormal liver function of serum aspartate aminotransferase and alanine aminotransferase, age and serum bilirubin are 1.5 times that of ULN;
* vomiting 24 hours before chemotherapy begins;
* Start systemic corticosteroid therapy within 72 hours prior to study drug use, or plan to receive corticosteroids as part of a chemotherapy regimen;
* Patients with benzodiazepines or opioids
Study of Levofloxacin-based Concomitant Therapy for H. Pylori Eradication in Diabetic Patients

The study aims to evaluate H. pylori eradication rate in diabetic patients by using novel 10-day levofloxacin-based concomitant therapy compared with conventional 10-day sequential therapy.


Eligibility Criteria:
Inclusion Criteria:

* Diabetic patients with Helicobacter pylori infection

Exclusion Criteria:

* Pregnancy or physically poor performance status
* Patients with contraindication for upper endoscopy
* Severe coagulopathy for endoscopic biopsy
* Chronic kidney disease (eGFR \< 50) or end stage renal disease
* Known allergy to interventional drugs
* Previous eradication failure
Effects of Platelet-Rich Fibrin in Patients With Anterior Cruciate Ligament Reconstruction

The study was conducted to investigate the effects of platelet-rich fibrin on knee stability, knee muscle strength and knee function in patients with ACL reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups. Patients were assessed preoperative and at the postoperative 1-year.

The study was conducted yo investigate the effects of platelet-rich fibrin (PRF) on the knee stability and function in patients with anterior cruciate ligament (ACL) reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups (PRF group and control group). Hamstring tendon autograft was used in all patients for the reconstruction of the teared ACL. A standardized postoperative rehabilitation program was applied to all patients. Patients' knee stability, knee muscle strength and knee function were assessed preoperatively and one-year postoperatively. Knee stability was assessed using KT-2000 Knee Arthrometer. Quadriceps femoris and hamstring muscle strength measurements were conducted with an isokinetic dynamometer at 60˚/sec and 180˚/sec angular velocities. One Leg Hop (OLH) and Y-Balance tests, and International Knee Documentation Committee (IKDC) were used to evaluate the knee function.

Eligibility Criteria:
Inclusion Criteria:

* Being isolated ACL reconstruction,
* Being between the ages of 18-45 years,
* Performing sports recreationally or professionally

Exclusion Criteria:

* Having previous knee surgery,
* Having systematic disease,
* Having multiple ligament injury on the knee or additional cartilage injuries
Difficult Intubation and Anthropometric Measurement

OBJECTIVE: This study aimed to determine the sensitivity and specificity of various anatomic measurements alone or in combination in predicting difficult intubation. The investigators hypothesized that goniomastoid distance, thyrogonial distance and tongue movements are sensitive and specific tests for predicting difficult intubation MATERIALS AND METHODS: The investigators included the data of 170 patients (85 difficult intubation and 85 easy intubation) who underwent an abdominal surgery under general anesthesia. Patients in difficult intubation (n=85) and easy intubation (n=85) groups were matched by age, BMI, and gender. Intubation difficulty scale (IDS) scores were recorded. Upward and downward maximal protrusions of tongue (UMPT and DMPT, respectively) were evaluated in all patients. Anthropometric measurements were measured.

To define the tongue protrusion tests, anatomic landmarks and horizontal lines were used. The first horizontal line (lower target line) was passing through the midpoint of the distance between stomion to mentum (mandible height) and the second horizontal line (upper target line) was passing through the midpoint of the distance from subnasal to stomion (upper lip height). The horizontal lines were drawn with an erasable marker pen on the each patient's face. In the sitting position, patients were asked to make maximal tongue protrusion upward (UMPT) and downward (DMPT) in anatomical neutral position. The inability of the tip of the tongue to reach to the target line was scored "1" and ability of the tongue tip to reach or pass the target line was scored "2

Eligibility Criteria:
Inclusion Criteria:

* Undergoing abdominal surgery with general anesthesia
* Able to sit

Exclusion Criteria:

* Enable to sit,
* Patients had head or neck surgery,
* Patients with unstable cardiological and respiratory hemodynamic symptoms,
* Dental prosthesis
Stress Management and Resiliency Training Following Acute Myocardial Infarction

The goal of this pilot study is to use total body PET/CT imaging to examine the relationships between stress, amygdala activation, and arterial wall inflammation in participants before and after participating in a multi-modal stress reduction program.


Eligibility Criteria:
Inclusion Criteria:

* Concurrently enrolled in an observational study of patients who have had an acute myocardial infarction
* Score on PSS-10 of 14 or greater during screening
* Willing and able to access the internet to participate in the online SMART Program

Exclusion Criteria:

* Poorly controlled physical or mental health condition that would likely interfere with the ability to participate in SMART or ability to undergo PET scan
* Current daily practice of meditation of 10 minutes or more per day
Multi-Center Study of Different Doses Domperidone in Feeding Intolerance

The purpose of this clinical multi-center study is to determine whether different doses of domperidone are effective in the treatment of feeding intolerance in premature infant

the premature infant have been divided into four group.The first group take the 0.2mg/kg/tds domperidone as treatment ,while the other group take the 0.4mg/kg/tds domperidone,0.6mg/kg/tds domperidone and the placebo respectively .

An objective index has been decided to evaluate the severity of feeding intolerance in the premature infant. 3kg/kg 5% glucose will be injected into the gastric tube .The residual glucose will be drawed out from the gastric tube. The residual percentage is the main result of the study.

The main result will be compared by the secondary result to help to explain the accuracy. The secondary result is the percentage of residual milk drawed out from the gastric tube from how many milk the infant take 3 hours ago.

Any adverse effect will be recorded and analysed to figure out whether is associate with the domperidone.

Eligibility Criteria:
Inclusion Criteria:

* the residual milk and glucose over 55%
* abdominal distention or vomiting;
* Reduce,delay or disruption of enteral feeding

Exclusion Criteria:

* Four weeks before the start of this study had participated in other clinical trials
* pulmonary hypertension;
* Infants with necrotizing enterocolitis
* Gastrointestinal tract malformation, congenital heart disease
* Pre-existing QT extend/between long QT syndrome;
* ascites
* Have been used or will use drugs suppress CYP3A4
* Other risk factors for prolong the QT
Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial

Total Knee Arthroplasty (TKA) is a common orthopedic surgery usually leads to Bleeding. The null hypothesis of this study was that TA has no effect on post surgical bleeding in patients undergoes TKA.


Eligibility Criteria:
Inclusion Criteria:

* Individuals with osteoarthritis who indicated for primary TKA.

Exclusion Criteria:

* Previous history of ceberovascular diseases
* Previous history of myocardial infarction
* Candidates for bilateral TKA
IMPROVE-DiCE: Study to Evaluate Effect of IMB-1018972 on Cardiac Energetics in T2DM & Obesity (Pt 1) With HFpEF (Pt 2)

The purpose of this study is to assess the activity of IMB-1018972 on cardiac energetic reserve at rest and during stress and to assess safety and tolerability


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of type 2 diabetes
* Elevated HbA1c
* Elevated BMI
* Preserved left ventricular ejection fraction
* Diagnosis of HFpEF (Stage 2 only)

Exclusion Criteria:

* Uncontrolled hypertension
* Contraindication to magnetic resonance scanning
* More than mild to moderate valvular heart disease
* Atrial fibrillation
* History of sustained ventricular tachycardia or cardiac arrest
* Inability to exercise (Stage 2 only)
* Clinically significant concurrent condition which could prevent the patient from performing any of the protocol-specified assessments, represent a safety concern if the patient participates in the trial or could confound trial assessments of safety or tolerability