cyrilzakka/clinical-trials huggingface dataset:
The Effects of Music and Television on Intraoperative Hypertensive Events in Cataract Surgery

This study investigates whether television viewing or music listening can reduce pre-operative anxiety and improve surgical outcomes for patients undergoing cataract surgery. It aims to determine the effectiveness of these interventions compared to a control group and assess their impact on physiological markers of anxiety as well as the incidence of intra-operative hypertensive events.

The key questions that are to be answered are:

1. Does watching television before cataract surgery decrease intraoperative hypertensive events and/or pre-operative anxiety in patients?
2. Does listening to music before cataract surgery decrease intraoperative hypertensive events and/or pre-operative anxiety in patients?

The study addresses the gap in literature regarding TV viewing's efficacy in ophthalmic surgery anxiety reduction. It aims to provide insights into cost-effective methods for stress reduction and surgical optimization. Through voluntary participation and rigorous methodology, it seeks to enhance patient experience and outcomes in ophthalmic surgery.

* Study Design: Randomized controlled design with three groups: control, television intervention, or music intervention.
* Objective: Investigate effects of TV viewing and music listening on pre-operative anxiety in ophthalmic surgery.
* Comparison: Compare relaxation effects of TV and music.
* Participants: Aim to recruit 200 per intervention arm from Montefiore Medical Center.
* Baseline Assessment: Measure anxiety levels pre-intervention.
* Interventions: Administer TV or music for 20 minutes pre-surgery.
* Assessment: Evaluate anxiety levels and physiological markers pre- and post-intervention.
* Monitoring: Monitor vital signs during surgery and post-operative period.
* Data Collection: Document demographic info, medical history, and baseline anxiety.
* Measurement Tools: Use Visual Analog Scale (VAS) for subjective assessment and physiological markers.
* Analysis: Compare outcomes across intervention arms using statistical tests.

Eligibility Criteria:
Inclusion Criteria:

* Participants undergoing cataract surgery at Montefiore Medical Center

Exclusion Criteria:

* Participants with severe hearing loss or speech impairment
* Participants with vision loss greater than count fingers
* Participants with uncontrolled hypertension (defined as \>160/\>100 despite use of antihypertensive medication)
* Participants who do not have the capacity to provide consent or who require a surrogate to provide consent
Diagnostic and Prognostic Value of Miss-1 Study in Children and Adult With Nephrotic Syndrome MISSNEPHROTIQUE

The nephrotic syndrome is a rare disease defined by a proteinuria \>3g/24h and a hypoalbuminemia \< 30g/L. Genetic and immune are the main causes. The acquired idiopathic nephrotic syndrome presents histologically minimal glomerular lesions, sometimes associated with segmental and focal hyalinosis. The idiopathic nephrotic syndrome (INS) represents 85% of children's glomerular nephropathy and 25-30% of adult's.

Relapses are frequents, and can be pejorative up to 10% and lead to end-stage kidney failure.

Another immune cause is the extramembranous glomerulonephritis mediated by molecular targets specific autoantibodies expressed at the podocytes surface.

Other immune causes include lupus nephropathy, ANCA vascularitis, Goodpasture disease, Berger disease.

Easy diagnosis between these causes can be made with the renal biopsy.

Miss-1, a new protein activated during a inflammatory event, could be an actor in nephrotic syndromes by modifying the podocyte's adhesion on the glomerular basal membrane. This would modulate the structure and function of the slit diaphragm, as well as junctions between the podocyte and the glomerular basal membrane, regulating podocytes' apoptosis.

This project is meant to propose and validate specific and non-invasive diagnostic and prognostic tests for the acquired idiopathic nephrotic syndrome.

These tests rely on the measure of Miss-1 expression in circulating blood cells on flow cytometry and its plasmatic concentration.

To date, no equivalent tests exist to diagnose idiopathic nephrotic syndrome (INS) from other causes.

These simple tests would allow a quick diagnosis of acquired INS by avoiding an invasive renal biopsy. It would also help anticipate the relapses of the disease and guide the treatment modalities as do nowadays the PLA2R antibodies in idiopathic membranous nephropathy.

We will propose the tests to every consent patient, hospitalized in the participating centers (Néphrologie pédiatrique of Robert Debré hospital, Néphrologie adulte of Tenon hospital) with a nephrotic syndrome.

Eligibility Criteria:
Inclusion Criteria:

* All new hospitalized patient
* Presenting a nephrotic syndrome according to its definition
* For which an anatomopathological diagnostic and its evolution can be or will be carried
* Children of any age can be included if they present a nephrotic syndrome

Exclusion Criteria:

- Patients already treated with glucocorticoids and/or immunosuppressor
Foot and Ankle Edema Post-Cesarean Delivery

Some women develop swollen feet and ankles after a cesarean delivery. These women will often complain that their shoes are too tight and their feet may become numb or they may have some tingling in their feet.

Currently we do not know for sure that foot swelling occurs after a cesarean delivery and if it does what the cause is.

If we find that feet do swell after a cesarean delivery we may be able to suggest a cause. This may in the future prevent women developing excessive foot swelling.

We aim to investigate whether the size and shape of women's ankles do change following an elective cesarean delivery. We plan to investigate, if possible, the cause of any foot swelling after a cesarean whether it be the volume of intra venous fluids or oxytocin use.

Pregnant women booked for an elective Cesarean delivery will be recruited into the study. Their foot volumes, based on volumetry, and foot and ankle circumferences will be measured prior to administration of IV fluids and then at 24 and 48 hours post delivery. They will also be questioned about their feet with regards to swelling, any symptoms of edema, and their mobility in the preceding two hours. Total fluid balance for the first 24 hours post delivery will be calculated, using the estimated blood loss in the OR, urine output, IV hydration and oral intake. The amount of oxytocin used will also be recorded. The parturient will be asked to fill in a form indicating the amount of oral fluid consumed in the first 24 hours post delivery. Information in the anaesthetic technique, height of block, use of vasopressors etc will be collected retrospectively from the anesthetic chart.

To reduce the chance of the caregivers altering their practice during the study, the attending anesthesiologist for the elective cesarean delivery will be unaware of the subject's participation in the study so that the IV fluids he or she gives will be as close to real practice as possible.

Current practice for IV start and infusion in the surgical daycare area will be used during the study period without modification.

Validation and reproducibility will also be investigated. Each investigator will measure the volume and circumference of the same limb 10 times and inter and intra tester reliability will be calculated.

Eligibility Criteria:
Inclusion Criteria:

1. Women with a singleton pregnancy;
2. Undergoing an elective CD under regional anesthesia (spinal or combined spinal epidural (CSE);
3. Normotensive; and
4. At least 37 weeks gestation

Exclusion Criteria:

1. Reasons for potential excessive blood loss (e.g. placenta previa);
2. Reasons for potential uterine atony and above average use of oxytocin (e.g. multiple pregnancies, polyhydramnios);
3. Non lower segment uterine incision;
4. Renal or cardiac disease;
5. Use of diuretics; or
6. Open wounds on the right foot and ankle.
Brain Imaging of Psychotherapy for Depression

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.


Eligibility Criteria:
Inclusion Criteria:

* For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder
* For group 1: Hamilton Depression Rating Scale score of 15 or greater

Exclusion Criteria:

* A history of serious head injury or neurological disease or psychosis
* Current use of psychoactive medications
* Factors that could affect MRI safety including current or planned pregnancy
* For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview
Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury

The purpose of this single-center, double-blinded randomized control trial with prospective data collection is to assess the ability of platelet rich plasma (PRP) treatment to reduce the level of pro-inflammatory synovial fluid biomarkers following an acute anterior cruciate ligament (ACL) tear. The study will collect and analyze synovial fluid of patients presenting with an acute anterior cruciate ligament (ACL) tear with a second synovial fluid sampling at the time of surgery. It will compare synovial fluid biomarker levels between those receiving an intra-articular Platelet Rich Plasma (PRP) injection versus an intra-articular saline injection serving as a control. Post-operative clinical outcomes will also be assessed, including post-operative pain levels, incidence of post-operative knee stiffness and patient reported outcome scores.


Eligibility Criteria:
Inclusion Criteria:

* Patients have suffered an acute ACL tear (initial presentation within 7 days of injury) with or without an associated meniscus injury
* Patient must undergo ACL reconstruction surgery

Exclusion Criteria:

* Mentally impaired (e.g, Alzheimer's subjects, dementia, etc.)
* Younger than 18 years of age
* Patients who have a multiligamentous injury
* Patients with underlying inflammatory arthropathies
* Previous ACL injury and/or reconstruction
Parenteral Nutrition Light Protection and Premature Outcomes

Investigators propose a prospective study to investigate the effect of full light protection of the PN on cholestasis and other oxidative stress associated diseases in premature infants when they receive PN for more than one week. Each infant enrolled in this study will receive full PN light protection including the PN bag, lipids and tubing. Demographic characteristics, clinical outcomes (incidence of cholestasis, feeding tolerance, BPD, ROP, NEC and mortality) and oxidative stress markers (e.g., carboxyhemeglobin) will be evaluated. Phase one of this study employed a retrospective chart review methodology to evaluate the effect of no PN light protection vs partial PN light protection (PN solution only while it's the tubing and lipids remained exposed to light). Infants from phase one of this study will serve as the controls in the evaluation the effect of full PN light protection on the cholestasis, clinical outcomes and oxidative stress. Investigators propose to collect urine and saliva samples in infants who we expect to receive PN for a minimum of 5 days, on days 0, 3, 5 and every 7 days after TPN initiation until 2 weeks after the end of IV nutrition to evaluate oxidative stress.


Eligibility Criteria:
Inclusion criteria

* Preterm infants \<32 weeks of gestation, who receive TPN for a minimum of 5 days
* Infants with gastrointestinal surgical problems (e.g., ileal atresia, gastroschisis), expected to receive TPN for a minimum of 5 days Exclusion criteria
* Infants who receive TPN for \<5 days
* Infants who developed cholestasis due to non-TPN-related causes
An Ecological Analysis of Nontuberculous Mycobacteria in the Geneva Area (2015-2020)

Prevalence of NTM diseases has been increasing regularly over the past 30 years in industrialized countries Although NTM are identified worldwide, there are important geographical disparities as to the relative prevalence of NTM species There are no data covering the ecology of NTM in Switzerland. Because of the progressive increase in NTM clinical cases in area Geneva(as noted in other industrialized countries), reporting the specific NTM distribution is important and relevant. In this study, the investigators aimed to: 1/ describe the relative prevalence of NTM species in clinical samples analyzed in the Geneva area, covering ca 500'000 inhabitants over a 5-year period; 2/ determine how many culture positive patients were treated; and 3/ specify the clinical sites involved.

This study was performed in the Geneva University Hospitals (HUG), a 2008-bed complex providing care for a population of ca. 500'000 inhabitants. All clinical samples sent for microbiological analysis within HUG are treated by the Bacteriology Laboratory of Geneva University Hospitals. An online database is kept up-to-date and includes all samples processed by the laboratory. The investigators performed a comprehensive analysis of all clinical samples included in this database over a 5-year period (2015-2020). This report focuses only on positive results for nontuberculous mycobacteria (NTM).The following items were recorded: age, gender, BMI whenever available, site of infection (when pulmonary: description of main radiological abnormalities), presence and type of immunosuppression, relevant pulmonary and non-pulmonary comorbidities, results of microscopy, and NTM species identified. The investigators also recorded whether the patient was treated for the identified NTM or not and if a susceptibility profile had been determined (this is not routinely performed and must be requested by the clinician).

The study protocol was approved by their local ethics committee

Eligibility Criteria:
Inclusion criteria - patients with positive clinical samples for nontuberculous mycobacteria (NTM)

Exclusion criteria

- None
Trauma Triage Decision With Software (TraumaDS)

It is intended to show that a computer software called Trauma Decision System (TravmaDS) for the determination of the urgency of trauma patients who applied to Emergency Medical Clinic gives more accurate, more objective, faster results than the triage scored by medical and non-medical personnel and to show the fact that TraumaDS provides more patient satisfaction.

There are limitations in our routine standard of practice in Emergency medical clinic in rapid triage about the adequacy particularly in the patient group where specific and rapid decision-making, such as trauma. The process of evaluating the patients who are directed to the green area unnecessarily in trauma care by the physician is prolonged, the evaluation process of patients who are directed to the red area unnecessarily shortens but hospital resources are being used extensively. Therefore, in this study, it was planned to perform objective triage with a computer based scoring system. Triage scoring determined by the Ministry of Health (SB ), routinely performed by an emergency medical technician (EMT), will be applied when the patients are admitted to emergency services. According to this scoring, patients who need urgent care and who should not wait less than 15 minutes will be considered red coded, patients who can wait up to 60 minutes will be considered yellow coded, patients who can wait for 120 minutes or more will be considered green coded. To the other group, triage maintenance / evaluation will be done with computer software developed by us. All patients with trauma should be included in the study, demographic data, trauma mechanism and trauma type vital signs at the time of application of the patients will be routinely observed in both groups of patients. These observations are routine for this disease group and we will not undertake any interventional procedures or screening except special routine application for research purposes. The observation and file information will be organized by the triage staff in both groups at the time of the application of the patients. In this software-based program before working on the software informative training will be given to triage staff and for this patient triage handheld computers will be given to triage staff. In order for the referring patients to be able to see the entries made with the triage software a simultaneous large-screen monitor will be used. At the time of application, color codes indicating the urgency of the patients will be given according to the demographic data of the patients, the type of trauma and the vital signs were directed by the software program. As a result of the software program's direction, patients will be coded as green-yellow-orange-red area and patient care will be made in accordance with these codes.

Eligibility Criteria:
Inclusion Criteria:

* all trauma patients who want to participate

Exclusion Criteria:

* who do not want to participate, who are not triaged, who leave the hospital before the treatment is completed
An Evaluation Of PF-03715455 In Moderate To Severe Chronic Obstructive Pulmonary Disease

This study proposes to evaluate the safety and efficacy of PF-03715455 in subjects with moderate to severe Chronic Obstructive Pulmonary Disorder.


Eligibility Criteria:
Inclusion Criteria:

* Female subjects of non-childbearing potential and male subjects between the ages of 40 and 80 years, inclusive
* Subjects with a diagnosis, for at least 6 months, of moderate to severe COPD and who meet the criteria for Stage II-III disease
* Subjects must have a smoking history of at least 10 pack-years

Exclusion Criteria:

* Current evidence or history within the previous 6 months of any clinically significant disease (other than COPD) or abnormality in the opinion of the Investigator that would put the subject at risk or which would compromise the quality of the study data
* A COPD exacerbation requiring treatment with oral steroids or hospitalization for the treatment of COPD within 3 months of Screening
Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy

The purpose of this study is to examine deficits in activation and motor patterns, as well as central drive in patients with rotator cuff tendinopathy. There are three specific aims: (1) determine the effect of acute pain relief on rotator cuff muscle activation in patients with rotator cuff tendinopathy, (2) determine the effect of exercise on rotator cuff muscle activation in patients with rotator cuff tendinopathy, and (3) compare rotator cuff muscle activation between patients with rotator cuff tendinopathy and healthy controls.

The long-term goal of our research agenda is to identify the mechanisms associated with rotator cuff tendinopathy (impingement syndrome) and subsequently evaluate novel treatment strategies that address these mechanisms. The objectives of this application are to study the muscle patterns in patients with rotator cuff tendinopathy as well as the effects of both pain and exercise on these patterns. Our first hypothesis is that pain relief from a shoulder injection will result in increased rotator cuff activity. Our second hypothesis is that patients with tendinopathy will demonstrate improved rotator cuff muscle activity following a six-week exercise program and that this improvement will be higher in patients that respond favorably to treatment. Our final hypothesis is that patients with cuff tendinopathy will show decreased rotator cuff activity compared to healthy subjects. The investigators plan on addressing these hypotheses using several novel techniques for muscle activity assessment.

Eligibility Criteria:
Patient Inclusion Criteria:

* pain with passive provocative maneuvers (positive Hawkins or Neer test)
* pain with active elevation (positive painful arc)
* pain with isometric resisted movements (Jobe's "empty can" test or resisted shoulder external rotation with the arm at the side)
* demonstrate weakness (\>10% force deficit in external rotation)

Patient Exclusion Criteria:

* shoulder surgery on the symptomatic side
* positive Spurling test
* traumatic shoulder dislocation or instability in the past 3 months
* reproduction of shoulder pain with active or passive cervical range of motion
* signs of rotator cuff tear (drop-arm test, lag signs, gross external rotation weakness, or positive image findings)
* current musculoskeletal, neurologic or cardiovascular compromise

Control Inclusion Criteria:

* no current or previous shoulder injury
* matched for age (within 5 years) and sex
* meet Patient Exclusion Criteria (minus musculoskeletal, neurologic, or cardiovascular compromise)

Control Exclusion Criteria:

* pain with active arm elevation
* positive Hawkins, Neer, or Jobe's test
An Adaptive Study to Match Patients With Solid Tumors to Various Immunotherapy Combinations Based Upon a Broad Biomarker Assessment

The purpose of this study is to evaluate the treatment of solid tumors with various immunotherapy combinations. The treatment will be determined based upon a broad biomarker assessment.


Eligibility Criteria:
Inclusion Criteria:

* Participants must have an ECOG performance status of less than or equal to 1
* Participants must have had prior therapy;Participants who have received adjuvant or neoadjuvant anti-PD(L)1 therapy andprogressed within 6 months of completing therapy will be considered IO refractory.
* Participants must have at least 2 lesions with measurable disease as defined by RECIST Version 1.1

Exclusion Criteria:

* Participants with suspected, known, or progressive CNS metastases, have untreated CNS metastases, or have the CNS as the only site of disease
* Participants with carcinomatous meningitis
* Participants with other active malignancy requiring concurrent intervention

Other protocol defined inclusion/exclusion criteria could apply
Study of Effects of Dao-In Exercise on the Perimenopausal Women With Sleep Disturbance

Among health problems of peri-menopausal women, sleep disturbances is very common complaint. The aim of this study is to realize the body constitution of the peri-menopausal women with sleep disturbance; and to evaluate the effects of Duo-in practice on this population to see if this intervention can decrease the dosage of hormone replacement therapy.

Quasi-experimental design and convenient sampling are both adopted. Participants will be recruited from China Medical University, Tri-Service General Hospital, Taiwan Society of Health Promotion, and Dr. Chen's Obstetrics and Gynecology Clinic. One hundred of participants who are willing to try Duo-in exercise to improve their sleep quality will be randomly assigned into experiment group and control group. The experiment group will practice Duo-in exercise 20 minutes every day for 2 months; while there is no intervention in the control group. Then, after 2 weeks, the participants of experiment and control group will crossover. The experiment group has no intervention, but the control group will practice Duo-in exercise for 2 months. Chinese version of the Pittsburgh Sleep Quality Index (CPSQI), Body Constitution Questionnaire (BCQ), peri-menopausal disturbance scale, and peri-menopausal fatigue scale will be used in the assessment at each time point. According to previous experience, a total of 70 participants will completed the whole observation course. Generalized estimating equations (GEE) is applied to analyzed the repeated measurement of different time and groups.

This study will provide the evidence for Duo-in exercise as complementary treatment for hormone replacement therapy for peri-menopausal women, and also for integration of Dao-in exercise into mainstream treatment for other patients with sleep disturbance.


Eligibility Criteria:
Inclusion Criteria:

* peri-menopausal women who have sleep disturbances.
* peri-menopausal women who can walk freely and without any disable.

Exclusion Criteria:

* peri-menopausal women who have cancer and other life-threatening diseases.
* peri-menopausal women who have psychological diseases.