cyrilzakka/clinical-trials huggingface dataset:
Analysis of the Posterior Wall Fracture of the Acetabulum

Assessement,evaluation of postoperativ reduction of posterior wall acetabular fractures in Assiut University Hospital

Posterior wall fracture of the acetabulum resemble 30% of acetabular fracture,surgical treatement is the 1st choice now for most of these fractures as it aimes to restore joint conjuroity and decreases the possibelities of osteoarthrities of the hip joint,in this study investigators will make analysis and assessement of the quality of postoperative reduction which is the main indicator of outcome of acetabular fractures in adult patients in Assiut University Hospitsls

Eligibility Criteria:
Inclusion Criteria:

* adult patients of both sexes with posterior acetabular wall fracture either isolated or associated with other fractures

Exclusion Criteria:

* other types of acetabular fractures not associated with posterior wall fracture
The Adjunctive Use of Lavender and Peppermint Essential Oils

This study will use passive inhalation of lavender for discomfort, anxiety and peppermint for nausea following joint replacement and spine surgery

Following review of records for eligibility and consent obtained during pre op visit subjects will be enrolled in study post op they will validate desire to participate and chose to inhale (2 drops of essential oil on cotton ball in a plastic bag) lavender for discomfort or anxiety or peppermint for GI distress

Visual analogue scales will be used to rate discomfort , anxiety and nausea

Eligibility Criteria:
Inclusion Criteria:

- elective joint replacement able to read and speak English and describe study procedures

Exclusion Criteria:

pregnancy

* unable to smell, sensitivity to fragrances asthma or breathing problems have smoke or vaped in last 2 weeks if atrial fibrillation history no peppermint uncontrolled hypertension above 160/100 non employees of UH or students of CWRU
eHealth-based Bavarian Alternative Detection of Atrial Fibrillation: A Randomized Controlled Trial (eBRAVE-AF)

Atrial fibrillation (AF) is the most common arrhythmia in western countries and causes of up to one quarter of ischemic strokes. The randomized eHealth-based Bavarian Alternative Detection of Atrial Fibrillation study (eBRAVE-AF) tests the efficacy of an e-health based strategy for the detection of AF. The e-health-based strategy consists of a smartphone-based photophlethysmographic (PPG) screening and an ECG-based validation.


Eligibility Criteria:
Inclusion Criteria:

* policy holders of a large health insurance company
* age ≥50 years
* CHA2DS2-VASc ≥1 (females ≥2)

Exclusion Criteria:

* atrial fibrillation
* oral anticoagulation
Surveillance of Rotavirus Gastroenteritis in Children <5 Years

The purpose of this study is to monitor diarrheal disease and observe changes after the introduction of the rota vaccine.

Monitoring of diarrheal disease and observe changes after the introduction of the rota vaccine Comparing the epidemiology in Jewish and Bedouin population before and after the introduction of the rota vaccine into the national immunization program

Eligibility Criteria:
Inclusion Criteria:

1. Children \< 5 years with
2. Gastro enteritis
3. Visiting the ER
4. Residents of southern Israel
5. Signed informed concent -

Exclusion Criteria:

Not all of the above
Perioperative Care in Ethiopia

A national cross-sectional survey of surgery and anaesthesia at Ethiopian public hospital facilities.

Incorporating elements from recognized surgical and anesthesia facility assessment tools the survey assesses surgery and anaesthesia at Ethiopian public hospital facilities.

The surveys assesses infrastructure, workforce, and availability of resources across all National facilities providing surgery.

An online national cross-sectional survey, designed through a consultative process involving senior clinicians - anesthesia providers, surgeons, and obstetricians.

Elements incorporated from existing tools, including the Safe Surgery Hospital Assessment Tool, World Federation of Societies of Anaesthesiologists (WFSA) Anaesthesia Facility Assessment Tool and the Lancet Commission on Global Surgery Surgical Assessment Tool.

Survey questions grouped into themes: infrastructure, human resources, service delivery, and the availability of medications, equipment, and guidelines.

The final quantitative survey includes 77 questions, for distribution to clinicians at a convenience sample of government hospitals providing major surgical services. Private facilities are excluded.

The online survey link sent via the N4PCc collaborator network to clinicians at each site. All collaborators and clinicians are perioperative practitioners (anesthesia providers, surgeons, obstetricians, nurses) at their respective institutions. Additional facilities with no N4PCc collaborator contacted via the department of anesthesia at each institution. Telephone follow-up with non-responding hospitals to overcome barriers to completion, including assistance with data input where required.

Eligibility Criteria:
Inclusion Criteria:

Clinicians working at facilities providing perioperative care Clinicians working in surgery, anaesthesia or obstetrics These will be recruited to provide data on perioperative capacity at all facilities providing surgery nationally

Exclusion Criteria:

Clinicians working out-with perioperative care Facilities not providing surgical services
LifeBio Memory Digital Reminiscence Platform

Non-pharmacological interventions and person-centered care strategies are important elements of care for people with Alzheimer's disease and related dementias. Life story work, which uses written and oral life histories to elicit conversation and memories, is an effective intervention for individuals with dementia; however, because of the time-consuming nature of generating useful life story materials, has not been widely implemented in nursing homes and other care environments. LifeBio Inc. will develop an easy-to-use reminiscence therapy platform - LifeBio MemoryTM - with a novel machine-learning-based application that converts speech to text and generates life stories to serve as an interactive tool to cultivate communication between people living with dementia and their family and caregivers.

This project offers the unique and timely opportunity to evaluate the feasibility, acceptability, and efficacy of LifeBio Memory's effectiveness as a solution for improving quality of life and quality of care for older adults in long-term care settings, as well as relationships with staff caregivers. This project will implement the the newly developed LifeBio Memory platform and train caregivers in X sites across the state of Ohio, with X residents and X staff participating in a feasibility trial. The program will be evaluated using three waves of data collection from staff during training and throughout implementation, as well as pre-post resident data to evaluate the effectiveness of the new intervention.

The LifeBio Memory platform addresses the need for an intuitive, artificial intelligence-driven solution to the traditionally labor-intensive process of collecting, sharing, and celebrating the life stories of older adults, as well as the development of tools for staff caregivers to enhance person-centered care practices and care-planning. It has great potential for improving psychosocial outcomes for participants, enhancing relationships between care staff and residents, and a cost-effective way to identify ways in which life stories can be used to provide a foundation for preference-based, personalized care.

Residents will be interviewed at baseline, then again at follow-up (4 weeks later), staff members being trained to utilize the LifeBio Memory application and provide feedback on the materials, as well as completed a survey at baseline, again at follow-up

Eligibility Criteria:
Inclusion Criteria (Staff):

* Work within a residential care facility participating in the study
* Speak and read English
* Able to provide own transportation to and from interviews with residents

Inclusion Criteria (Residents

* Must reside within a participating residential care facility
* Must be at least 55 years of Age
* Must speak and read English
* Have a Dementia diagnosis
* Have a Score of at least 15 on the Mini Mental State Examination

Exclusion Criteria (Residents)

* Residents will be excluded from the study if they show signs of rapid cognitive decline or physical deterioration over the last 6 months, as evidence by information gained during screening.
Intelligent Diagnosis and Treatment Model for Insomnia Disorder

To establish a multicenter, multi-dimensional cohort on insomnia disorder and to develop an intelligent model for the diagnosis and treatment of insomnia disorder.

The study endeavors to establish a multicenter cohort comprising 16,000 individuals diagnosed with insomnia disorder, with a subsequent 2-year follow-up. Objectives encompass elucidating the natural development of insomnia disorder within diverse populations, identifying associated factors, and evaluating the short-term and long-term impacts on physiological, psychological, and social functions in insomnia disorder. Additionally, the research aims to devise early screening methodologies, precise assessments, and innovative disease classifications utilizing real-time assessment technology within the insomnia disorder cohort. Furthermore, the investigation seeks to ascertain graded diagnoses, treatment modalities, and prognostic indicators based on advanced multi-dimensional real-time assessment technology applied to a substantial insomnia disorder cohort. Finally, the study aims to refine remote interactive diagnostic and treatment modalities tailored to diverse age groups, culminating in developing a systematic graded diagnostic and treatment framework for insomnia disorder.

Eligibility Criteria:
Inclusion Criteria:

1. A complaint of insomnia;
2. Age between 18 and 75;
3. Able to fill out the scale on their own;
4. Agree to sign the informed consent to participate in the study and cooperate in completing the follow-up visit.

Exclusion Criteria:

1.A current or history of comorbid Axis I psychiatric disorders.
Ketamine Effects as Preemptive Analgesia

The goal of this randomized controlled trial is to compare the effect of preemptive ketamine administration to placebo administration in patients underwent hysterectomy surgery. The main questions it aims to answer are:

1. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the duration of analgesia after hysterectomy surgery
2. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the need for fentanyl after hysterectomy surgery


Eligibility Criteria:
Inclusion Criteria:

1. Patients aged 18-50 years.
2. ASA I and II physical status (American Society of Anesthesiologists).

Exclusion Criteria:

1. The patient is not willing to be included as a research subject
2. The patient takes anti-pain medication before surgery
3. History of allergies to the drugs to be used
4. History of chronic pain
Isolation, Characterization and Evaluation of the Potential of TissuE-resideNt cElls From Waste Musculoskeletal and Associated Connective Tissues

The general purpose of this study is characterization of tissue-resident cells derived from different musculoskeletal and/or associated connective tissues (such as cartilage, synovial membrane, synovial fluid, bone, adipose tissue and tendons), in order to identify new strategies for the treatment of degenerative and inflammatory musculoskeletal disorders. Cells isolated from different tissue sources will be compared with each other by phenotypic and functional characterization, following culture and treatment with inflammatory elements, drugs and orthobiologics. Moreover, with the aim to assess predictive markers of therapeutic success, a correlation study of the content and properties of the cells isolated from different types of tissue with the clinical profile of the enrolled patients will be conducted.


Eligibility Criteria:
Inclusion Criteria:

* males and females

  * 18 years old
* patients undergoing elective surgery at IRCCS Istituto Ortopedico Galeazzi among which joint surgery (including hip or knee replacement), or anterior cruciate ligament (ACL) reconstruction or rotator cuff repair

Exclusion Criteria:

* age \< 18 years old
* patients unable to sign the Informed Consent
* positivity to virological test (HIV, HCV, HBV, TPHA)
Monitoring of Hypnosis State During General Anesthesia With Propofol by Patient State Index From SEDLine®

The purpose of this study is the evaluation of possible relationships and correlation between PSI values obtained from the SEDLine® monitor and the infusion rate of propofol during general anesthesia.

Introduction:

There is a large intra-and interindividual variability in the effect of propofol. To deal with this problem, a real-time monitoring and therefore a more accurate titration of anesthetic agents is proposed. Brain function monitors based on a processed analysis of EEG (Electroencephalogram) can help to control pharmacodynamic effects of hypnotic agents. PSI values provide a measurement of the hypnotic effect of propofol. It will be observed an inverse correlation between the propofol infusion rate and the PSI value.

Objectives:

To design a computer program to record simultaneously the propofol infusion rate, PSI and Electromyogram (EMG).

To study the correlation between PSI values obtained from the SEDLine® monitor and the infusion rate of propofol during general anesthesia.

To obtain a mathematical model of the system from data recorded with different identification techniques.

Methods:

A group of patients scheduled for surgery under a standard total intravenous anesthesia (TIVA) with propofol and remifentanil will be recruited. The hypnotic effect of propofol will be monitored with the PSI from a SEDline monitor continuously. All anesthetic doses and their changes fall within conventional dosing.

The procedure for recording data and obtaining the pharmacokinetics/pharmacodynamics (PK / PD) model will be connecting a SEDLine® monitor to a laptop with an original program developed by members of our team. The program automatically stores the infusion rate of propofol (mg/kg/h) and the simultaneous values of PSI and frontal EMG. Graphics and data collected will be explored with various systems of techniques for pattern recognition in order to get the best fit to define a mathematical model of the dose of propofol and PSI values. A subsequent computer analysis with MATLAB® will estimate the correlation between the infusion of propofol infusion rate and PSI values.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists classification of I, II, or III
* Patient signed an informed consent

Exclusion Criteria:

* Patients with prior neurological disease, epilepsy or stroke.
* Patients who are receiving drug therapy that may alter processed EEG monitoring and decrease the PSI accuracy.
* American Society of Anesthesiologists classification IV or higher
Focal Microvibration and Chronic Lumbosacral Radicular Pain

The goal of this clinical trial is to investigate the effectiveness of focal microvibration on patients affected by chronic lumbosacral radicular pain. The main question\[s\] it aims to answer are:

* Can focal microvibration improve pain in this patient population?
* Can focal microvibration improve quality of life in these patients? Participants will attach to their skin four little devices (10x20x0,5mm) delivering focal microvibration in the painful area according to researchers indications for 6 hours/day every day except Thursday and Sunday.

Researchers will compare patients treated with focal microvibration to patients treated with a sham device and to patients treated with standard pharmacological therapy.

This is the first randomized controlled study aiming to assess the potential use of focal microvibration for the management of chronic lumbosacral radicular pain which is the pain consequent to the compression of a spinal nerve root. Focal microvibration has been so far used to treat gait disorders and instability consequent to diseases such as Parkinson's disease, stroke, ataxia, multiple sclerosis with impressive results and no reported side effects. Our trial involves three arms: one arm treated with a device able to deliver focal microvibration, one arm treated with a sham device, and one arm treated with standard pharmacological therapy according to international guidelines. Patients with the active and with sham devices will attach them on their skin for 6 hours/day except on Thursday and Sunday: this application schedule with two days of treatment suspension has intended to avoid habituation to the sub-perception microvibration stimulation. The follow up will be 12 months and periodic visits will be performed after 7, 15 30, 45, 60, 90, 180, and 360 days of treatment. All the patients enrolled in the study will have access to rescue analgesic drugs such as paracetamol 1g and tramadol 100mg in case on excessive pain. Randomization will be performed by a computer-generated sequence. During the follow up visits, patients will be asked to fill questionnaires to explore and monitor pain intensity and pain interference in daily life: brief pain inventory (BPI) and Oswestry disability index (ODI)

Eligibility Criteria:
Inclusion Criteria:

* Pain duration≥6 months
* Magnetic resonance imaging (MRI) showing compression of lumbosacral nerve roots
* Neuropathic symptoms in the innervation territory of the compressed spinal nerve roots
* Monolateral pain
* Pain intensity: moderate-severe i.e. numeric rating scale (NRS)≥4.

Exclusion Criteria:

* Psychiatric patients
* Cancer patients
* Patients affected by disease characterized by spasticity or muscular stiffness:

Parkinson's disease, multiple sclerosis, stroke, spine injuries.

* Patients with spinal or dorsal root ganglion stimulators
* Patients undergone central of peripheral stimulation in the past 3 months
* Patients affected by fibromyalgia.
* Patients undergone central nervous system surgery
* Patients with reduced renal function eGFR≤60ml/min/1,73m2
Fluciclovine PET/CT in Multiple Myeloma Patients

Comparison between image findings at aminoacid PET/CT and FDG PET/CT for myeloma patients


Eligibility Criteria:
Inclusion Criteria:

* Multiple myeloma patients suitable for ASCT treatment

Exclusion Criteria:

* Patients with contraindications to ASCT treatment
Bioequivalency Study of Letrozole 2.5 mg Tablets Under Fasted Conditions

The objective of this study was to prove the bioequivalence of Letrozole Tablet under fasted conditions.


Eligibility Criteria:
Inclusion Criteria:

- No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening

Exclusion Criteria:

* Positive test for HIV, Hepatitis B, or Hepatitis C.
* Treatment with known enzyme altering drugs.
* History of allergic or adverse response to letrozole or any comparable or similar product.
Outcomes From Treatment Liver and Bile Duct Diseases

It is reported in the literature that the treatment of any liver and bile duct disease process, whether benign or malignant, continues to be a huge challenge. For example, patients with adenocarcinoma continue to be diagnosed at an advanced stage with medical and surgical options that are improving in terms of outcome measurements but with much more room for improvement. Our goal is to continue to review our treatment outcomes to further improve overall survival, overall symptom control, mortality and morbidity.

The main aim of this study is to evaluate and compare the outcomes from our multiple treatments of benign or malignant liver and bile duct diseases.

The study will be a retrospective chart review of patients who have been diagnosed with benign or malignant liver and bile duct disease under the practices of Rohan Jeyarajah, M.D., Houssam Osman, M.D., F.A.C.S., Edward Cho, M.D., Sc.M at Methodist Health System Hospital in Richardson, T.X. We plan to conduct an analysis of patients meeting the inclusion criteria form 2005 to present (up to the day before this study receives IRB approval). Charts will also be reviewed by the PI. Sub-I, Fellows, Office Staff, Clinical Research Coordinator who are delegated to do so by the PI. Data will be obtained from a national database. Data will be analyzed primarily by the study conductors.

Eligibility Criteria:
Inclusion Criteria:

* All patients diagnosed and treated for liver and bile duct disease benign or malignant from 2005 to present (up to the day before this study receives IRB approval)
* Age \> 18 years

Exclusion Criteria:

* Patients that are not diagnosed with or treated for liver and bile duct disease
* Age \< 18 years
The Hybrid Combination of CCTA and SPECT and CAG for Evaluation Prognosis of CAD: an Observational Follow-up Study

A total of 550 patients with stable angina (40-70% stenosis) tested by coronary CT angiography (CCTA) and single photon emission computed tomography (SPECT) and coronary angiography (CAG) within 3 months were retrospectively recruited from 2005 to 2015 and follow up to 5 years. A new hybrid software was used to analysis the image data.


Eligibility Criteria:
Inclusion Criteria:

1. Age: 18-70
2. Gender: All
3. coronary artery disease patients (CAD)
4. underwent CCTA, SPECT and coronary angiography (CAG) together within 3 months
5. Time: 2005-2015

Exclusion Criteria:

1. dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), congenital heart disease (CHD), atrial fibrillation (AF), ventricular tachycardia (VT)
2. Prior coronary revascularization;
3. permanent pacemaker or internal defibrillator
4. prosthetic heart valve
5. coronary image lose
6. coronary artery severe calcification
7. motion artifacts and poor CCTA image quality
PCOS Immune Function Predicts Metformin Efficacy

In this study, the investigators will include PCOS patients who meet the trial criteria, introduce participants to the content of this study, and invite participants to participate. The immune function of peripheral blood samples of PCOS patients was detected by flow cytometry. Participants were further treated with metformin for 6 months and followed up after the intervention. The objective of this study was to investigate immune markers related to the efficacy of metformin in PCOS patients and to predict the efficacy of metformin in PCOS patients using immune function.

In this study, peripheral blood samples of PCOS patients were collected before and after intervention. Flow cytometry was used to detect the antigenic antibody reaction between the surface differentiation antigen of lymphocyte membrane and fluorescently labeled antibodies in human peripheral blood, and the unlabeled cells were dissolved. The number and percentage of cell groups expressing different markers were counted by the fluorescence detection system on flow cytometry.

Eligibility Criteria:
Inclusion Criteria:

* aged 18-45 years
* Diagnosis of PCOS with the Rotterdam diagnosis criteria (2003)

Exclusion Criteria:

* Pregnant women;
* Hyperthyroidism or hypothyroidism
* Severe liver and kidney function injury
* Cancer patients;
* Associated with severe infection, severe anemia, neutropenia and other blood system diseases;
* Have type 1 diabetes, single-gene mutated diabetes or other secondary diabetes;
* Patients with mental illness or intellectual disability;
* Have taken drugs for PCOS treatment in the last three months;
* Have a long history of taking hormone therapy;
* Currently or recently participating in another clinical trial.