cyrilzakka/clinical-trials huggingface dataset:
Volatile Organic Compounds (VOCs) Profile in Colorectal Cancer Patients and Healthy Controls.

Volatile organic compounds (VOCs) are low molecular weight (\<1 kDa) compounds which represent the final products of cell metabolism. Their composition can be affected by several factors including diet, hormones, environment and the presence of diseases, in particular, cancer.

Colorectal cancer (CRC) is one of the commonest tumours and is an important cause of cancer-related mortality.

The expression of VOCs in breath that are linked to a patient's disease state could offers a powerful, non-invasive approach to identifying CRC patients.

Volatile organic compounds (VOCs) are low molecular weight (\<1 kDa) compounds which represent the final products of cell metabolism. Their composition can be affected by several factors including diet, hormones, environment and the presence of diseases, in particular, cancer.

Endogenous breath VOCs can originate anywhere in the body, reversed in the venous blood stream and than to the lung alveoli where some of them are exhaled .

Alteration in VOC production in patients with cancer has been postulated to relate to (per)oxygenation of cell membrane-based polyunsaturated fatty acids resulting from genetic and/or protein mutations within tumour cells and the increased relative prevalence of reactive oxygen species within cancer cells. VOCs consist largely of benzene, alkanes and aldehydes (or their derivatives), and several studies have demonstrated that various cancers, including lung and breast cancer,melanoma, mesothelioma and hepatocellular carcinoma, are associated with specific VOC profiles that differ from normal.

Volatile organic compounds are present in various excreted biological materials (urine, blood, faeces an breath) and their analysis offers a possibility for cancer screening.

Colorectal cancer (CRC) is one of the commonest tumours and is an important cause of cancer-related mortality. It is the second leading cause of cancer-related death in Europe and the third in the USA.

Colonoscopy is the gold standard for the diagnosis of CRC, although its cost prevents its use for mass screening. Furthermore colonoscopy is not well accepted by patients since it is an invasive exam. Faecal immunochemical blood testing (FIT) is the most widely used noninvasive screening tool, showing fairly good specificity but a high variation in sensitivity (61-91%) and adherence to screening programmes rarely reaches 50-70% of the target population.

The expression of VOCs in breath that are linked to a patient's disease state could offers a powerful, non-invasive approach to identifying CRC patients.

Eligibility Criteria:
Inclusion Criteria:

* Age between 18 and 95
* Histologically proven colorectal cancer
* Patient with single or multiple polyps of the colon
* Healthy subjects with negative colonoscopy
* Patients already sampled and operated for colorectal cancer with no sign of recurrence
* Written informed consent

Exclusion Criteria:

* Pregnancy
* Inflammatory bowel disease
* Synchronous cancers
* Liver and/or lung metastasis
* Bowel prep
* Recurrent CRC
* Any psychiatric disease
* Emergency operations
Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People

A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large amount of cardiovascular tests done in Singapore and how to better to predict outcomes and manage healthcare costs in our local populations

SingHEART sub-study will collect the following data types or perform the following investigations:

1. Demographic and clinical characteristics data.
2. Basic blood investigations. Basic blood investigations include: FBC, CRP, renal panel, random glucose, LFT, fasting lipids, ESR, CRP,
3. Perform a single baseline cardiac MRI (already consented and obtained as part of the primary study).
4. ECG
5. Calcium score
6. Biobanking (whole blood, plasma and serum, already performed as part of the primary study)
7. Exercise and physical activity tracker over two 1-week periods
8. Ambulatory BP monitoring over two 24-48H periods

Eligibility Criteria:
Inclusion Criteria:

* Men and women age 21-69 years

Exclusion Criteria:

1. Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI)
2. Known coronary artery disease - prior coronary revascularization
3. Known documented peripheral arterial disease
4. Previous stroke

   a. Stroke is defined as new focal neurological deficit persisting more than 24hours21.
5. More than ongoing use of 2 or more anti-hypertensive agents
6. Prior history of cancer (excludes pre-cancerous lesions)
7. Expected life expectancy less than 1 year
8. Known definite diabetes mellitus or on treatment for diabetes mellitus
9. Known autoimmune disease or genetic disease
10. Known endocrine disease on treatment
11. Psychiatric illness
12. Asthma or chronic lung disease requiring long term medications or oxygen
13. Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV
14. Inability to comply with study protocol
15. Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes
Cerebellar Loops and Attention Deficit Hyperactivity Disorder (ADHD)

The aim of this study is to investigate the integrity of connectivity between the neocortex and the cerebellum in the Attention Deficit Hyperactivity Disorder (ADHD). Fibers integrity will be measured using magnetic Resonance Imaging Techniques.

ADHD is a neurodevelopmental trouble characterized by attentional deficits, impulsivity and motor hyperactivity. Morphological neuroimaging studies in ADHD children have revealed cerebellar abnormalities, however data in adults regarding cerebellum alterations are scarce. In this study we will analyse the conectivity of the cerebellum of adults ADHD patients. We will use diffusion tensor imaging (DTI) technique, and morphological data will be compared with the neuropsychological status.

Eligibility Criteria:
Inclusion Criteria:

Patient with ADHD :

* Diagnosis of ADHD
* 18 - 35 years old

Healthy volunteer :

* 18 - 35 years old
* no ADHD diagnosed

Exclusion Criteria:

* Associated neurological or psychiatric pathologies
* Pregnant woman
* MRI counter indication
Evaluation of Technology-Based Stress Reduction Techniques Prior to Vascular Access

Preprocedural, preoperative, and prevascular access anxiety in pediatric patients has been previously shown to increase the likelihood of family stressors, postoperative pain, agitation, sleep disturbances, and negative behavioral changes. The purpose of this study is to determine if a non-invasive distracting devices (Virtual Reality headset) is more effective than the standard of care (i.e., no technology based distraction) for preventing anxiety before vascular access among hospitalized children undergoing vascular access prior to anesthesia, procedures, surgery, blood draws, port access, or peripheral IV placement. The anticipated primary outcome will be reduction of child's anxiety during and after vascular access.

Anxiety among children undergoing vascular access is common. Not only is high anxiety traumatic, but research indicates that high anxiety in children before surgery leads to adverse outcomes such as increased pain and analgesics requirements, delayed hospital discharge, and maladaptive behavioral changes. Treating anxiety may decrease any of these undesirable behaviors.

In this study, investigators hope to determine if technology based distractions (VR headsets) are more effective than standard care for preventing high anxiety before vascular access. As a secondary aim of the study, we seek to determine if the use of technology based distraction will result in higher parent and patient satisfaction, decreased fear, and increased compliance, while monitoring for side-effects of the intervention.

Eligibility Criteria:
Inclusion Criteria:

1. be between ages of 7-18 years of age
2. have comprehension of instructions in the English language
3. have parental consent
4. Pediatric patient must be undergoing non-emergent vascular access at Lucile Packard Children's Hospital in one of the 6 previously defined care areas (please see study design in Section 16).
5. Children who are normally healthy (ASA I) or have a mild systemic disease (ASA II,III)-

Exclusion Criteria:

1. Significant cognitive impairment/developmental delays per parental report or H\&P.
2. Children with ASA IV (severe systemic disease that is a constant threat to life) or ASA V (unstable patients not expected to survive \>24hours or without the operation)
3. H/o severe motion sickness, nausea, seizures
Phase 1 Clinical Trial to Evaluate the Safety, PK and PD of DA-5207 TDS in Healthy Adults

The purpose of this study is to evaluate the safety, pharmacokinetics and pharmacodynamics of DA-5207 transdermal delivery system in healthy adults


Eligibility Criteria:
Inclusion Criteria:

* Health Voulunterrs (Age : 19\~55 years)
* Body Weight : Male≥55kg, Female≥50kg
* 18.5 ≤BMI≤ 25.0

Exclusion Criteria:

* Galactose intolerance, Lapp lactase deficiency, Glucose-galactose malabsorption
* Allergy or Drug hypersensitivity
* Clinically significant Medical History
* AST, ALT \> Upper Normal Range\*1.25, eGFR\<60mL/min/1.73m²
* Heavy alcohol intake (more than 210g/week)
* Heavy smoker (more than 10 cigarettes/day)
* Heavy caffeine intake
Investigation of the Effect of Foam Roller and Kinesiotape Application on Performance Parameters, Pain and Fatigue With Football Players

The aim of our study is to compare the effects of foam roller plus dynamic stretching and kinesiotape plus dynamic stretching on performance parameters,pain and fatigue in football players. The results of our study will show the effects of the best choice between applications and help to reduce waste of time.

The aim of our study is to compare the effects of foam roller plus dynamic stretching and kinesiotape plus dynamic stretching on performance parameters,pain and fatigue in football players. The results of our study will show the effects of the best choice between applications and help to reduce waste of time. Performance parameters include; flexibility, dynamic reaction time, sprint and agility.

The hypotheses the investigators will test for this purpose; H1: Foam Roller application is more effective on performance parameters than Kinesiotape application. H2: Foam Roller application is more effective on pain than Kinesiotape application. H3: Foam Roller application is more effective on fatigue than Kinesiotape application.

Eligibility Criteria:
Inclusion Criteria:

* Playing in Aydın Adnan Menderes University Football Team and volunteering.

Exclusion Criteria:

* Individuals with medical conditions that may affect their ability to complete the work, such as recurrent muscle, bone, tendon, and ligament injuries, or a history of prior lower extremity surgery.
A Randomized Controlled Trial of an Exposure-Based Treatment for Perfectionism

This study is examining the efficacy of a computerized, exposure-based, intervention for perfectionism.

The aim of this study is to further test the efficacy of a short-term, computerized exposure-based treatment for perfectionism (ETP) by comparing it to a stress management condition. ETP consists of three tasks in which participants will repeatedly make mistakes during eight sessions over a two-week period (one session every 2 days).

Eligibility Criteria:
Inclusion Criteria:

- Score of at least 29 on the Frost Multidimensional Perfectionism Scale- Concern over Mistakes subscale

Exclusion Criteria:

* Currently participating in psychotherapy
* Any changes to psychotropic medications in the past four weeks
Pilot Study of the ACE System in Lung Procedures

To evaluate the XACT ACE Robotic System in lung procedures.

The XACT ACE Robotic System is a user-controlled positioning system intended to assist in the planning and advancement of an instrument during Computed Tomography (CT) guided percutaneous lung procedures. The system is used for trajectory planning and is intended to assist the physician in the positioning of an instrument, such as a needle, where CT imaging is used for target trajectory planning and intraoperative tracking. This study will evaluate safety and accuracy of the XACT ACE Robotic System in subjects undergoing CT guided, minimally invasive percutaneous procedures of the lung in the interventional radiology suite.

Eligibility Criteria:
Inclusion Criteria:

1. 18 years of age
2. Subjects undergoing CT-guided, minimally invasive percutaneous lung procedures in the interventional radiology suite, e.g., core biopsy, fine needle aspiration (FNA), tumor ablation, etc.
3. Following planning and registration CT scans, subject is found eligible to undergo CT-guided, minimally invasive percutaneous procedure
4. Subject is willing to sign informed consent
5. Subject is capable of adhering to study procedures

Exclusion Criteria:

1. Subjects in whom the target is within 1 cm of a major blood vessel, major nerve or heart
2. Subject with significant coagulopathy
3. Subject with preexisting or unstable medical condition(s), which in the opinion of the investigator, might interfere with the conduct of the study
4. Subjects who are pregnant or nursing
5. Following planning and registration CT scans, required clinical trajectory to target is beyond system workspace limits (e.g., entry angle is too sharp)
Sunlight Exposures Effect on Serum Vitamin D Levels

When people eat a meal, some, but not all of the calcium in that meal is absorbed, that is, moved into the bloodstream. When the skin is exposed to sunlight during summer months, Vitamin D is made there and then modified into more active forms by the liver and kidneys. These more active forms of Vitamin D improve calcium absorption. Many adults living in the U.S. have little or no sun exposure and are low in Vitamin D. We know that specific wavelengths of sunlight called Ultraviolet-B cause Vitamin D to be made in the skin.

At the beginning of the study we will measure your height, weight, skin color, and draw blood to measure your blood levels of Vitamin D and 25-hydroxyvitamin D. Each subject will wear a swimming suit and be exposed to sunlight for 30 minutes total (15 minutes lying on back, 15 minutes lying on stomach).We will draw blood for Vitamin D and 25-hydroxyvitamin D on days 1,2,3,5, and 7 after sunlight exposure. There will be six blood draws for a total of 102 cc of blood drawn (about 3 ½ teaspoons drawn each time).

Eligibility Criteria:
Inclusion Criteria:

* healthy males or females ages19-50 with "light" skin (self-assessed as Fitzpatrick skin type I-III) with minimal sun exposure and exogenous sources of vitamin D.

Exclusion Criteria:

* less than 16 oz milk per day, less than 10 hours of sun per week, no Vitamin D supplements, no anticonvulsants, no barbiturates, no steroids, no meds that increase photosensitivity, no granulomatous disease, no liver or kidney disease, no history of skin cancer, and BMI less than 30.
Translating a Heart Disease Lifestyle Intervention Into the Community

Translating a Heart Disease Lifestyle Intervention in the Community study will evaluate the feasibility and initial effectiveness of a community-based, culturally-targeted, lifestyle intervention to improve the cardiovascular health of underserved South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) Americans. Participants in this study will be randomly assigned to either a group to receive heart disease prevention classes or to another group where they will receive written materials about heart disease prevention.

South Asian individuals were recruited from a community based organization in Chicago and randomly assigned to the print health education group or the SAHELI intervention.

Eligibility Criteria:
Inclusion Criteria:

* South Asians between 30 and 60 years
* Have at least one CHD risk factor: obesity (body mass index \> 25 kg/m2- cutoff for obesity in South Asians), hyperlipidemia, hypertension, pre-diabetes, or diabetes.

Exclusion Criteria:

* Inability to speak English, Hindi, or Urdu
* History of clinically evident CVD (e.g. heart attack, stroke)
* Pregnant, lactating, or planning to become pregnant during the study period
* Conditions that inhibit moderate intensity physical activity
* Systolic blood pressure ≥190 or diastolic blood pressure ≥105; Triglycerides ≥ 400
* Using insulin for diabetes
* Significant medical or psychiatric co-morbidities
* Plans to move out of the area within 2 years
* Family/household member enrolled in study
A Study of Breast Cancer Risk Factors and Outcomes of People in Florida

The purpose of this study is to understand why different people have different risks and outcomes for breast cancer and non-breast cancer.


Eligibility Criteria:
Inclusion Criteria:

* Patients with BIRADS 0-5, seen in breast radiology clinic at University of Miami (UM), Sylvester Comprehensive Cancer Center (SCCC), Jackson Health Systems (JHS) for biopsy.
* Any new breast patient seen at UM/SCCC or JHS will be invited to participate in the study.
* Men and women 18 years of age and older are eligible to participate in the study.

Exclusion Criteria:

* Patients who are less than 18 years of age will be considered ineligible.
* Patients unable to complete the survey.
The Impact of MACA Supplementation on Basketball-related Performance

In this randomized crossover study, ten elite healthy male basketball players were included. Following a 17:00 PM training routine, participants completed a two-week supplementation with 2000 mg of MACA or placebo. After supplementation, participants underwent a Basketball Jump Shooting Accuracy Test and Repeated Sprint Ability Test.

Supplementation with Lepidium meyenii (MACA) has been shown in animal studies to increase blood lactate clearance and rapid lactate removal, which may be effective in reducing fatigue during intermittent exercise. However, no studies have investigated the effects of MACA supplementation on interval exercise and basketball performance. We hypothesized that MACA supplementation could reduce fatigue and improve performance in elite healthy male basketball players. This study aimed to determine the effectiveness of MACA compared to placebo on overall basketball performance.

Eligibility Criteria:
Inclusion Criteria:

* (i) healthy male adults, those individuals who are free of pain, insomnia, or other injuries recently, without any medication used in recent 2 months,
* (ii) basketball players competing in a Taiwan university basketball association for more than two years.

Exclusion Criteria:

* (i) were below 20 years old,
* (ii) did not have won at least eighth place in national-level basketball competitions,
* (iii) were with cardiovascular diseases or any disease that made subjects feel ill.
Cranial Remolding Orthosis Registry

A registry of infants fitted with a cranial remolding orthosis.

The intention of the CRO registry is to gather real-world data of traditional and 3D-printed cranial remolding orthoses to compare outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Patient has been evaluated and successfully scanned for a MyCRO Band or similar CRO
* Patient's parent(s) or legal guardian(s) are able to communicate, provide feedback, understand and follow instructions during the course of the registry.
* Parent(s) or legal guardian(s) are willing to provide informed consent.

Exclusion Criteria:

* Patient is geographically inaccessible to comply and participate in the registry.
Intraneural Facilitation Therapy and Nerve Flossing Technique in Patients With Diabetic Peripheral Neuropathy

The aim of this study is to determine the comparative effects of intraneural facilitation therapy and nerve flossing technique on pain, balance, gait, and quality of life in Diabetic peripheral neuropathy.

Intraneural Facilitation Therapy is a novel manual therapy technique that seeks to enhance endoneurial capillary circulation, bias blood flow into the neural fascicle, and reverse intrafascicular ischemia. To redirect blood to the ischemic nerves, this passive approach involves tractioning skin, distending visceral tissues, stretching muscles, mobilizing joints, and stretching blood vessels. The Nerve Flossing Technique is an emerging treatment approach that aims to improve neurodynamic, range of motion, and quality of life. Intraneural Facilitation and Nerve Flossing Techniques address diabetic peripheral neuropathy, and their effectiveness in improving pain, balance, gait, and quality of life remains un-compared.

This randomized clinical trial will be conducted at Social Security Hospital, and Siddique Family Hospital, Gujranwala. 44 Participants who meet the inclusion criteria will be selected through a non-probability convenience sampling technique and randomly allocated into two groups using an online randomizer tool. Participants will be included in Groups A (Intraneural Facilitation Therapy) and Group B (Nerve Flossing Technique). A total of 24 sessions (3x/week for 8 weeks) will be conducted, lasting 60 minutes each.. A Numeric Pain Rating scale will be used to assess pain, the Berg Balance Scale (BBS) to assess balance, a 4-item Dynamic Gait Index to assess Gait, and the Quality of Life-Diabetic Neuropathy (QOL-DN) for quality of life. Assessment will be carried out at baseline (before treatment), after the 8th week (post-intervention), and at a 2-month follow-up. The data will be entered and analyzed using the IBM SPSS Statistics 27.0 version. Statistical significance will be set at p ≤0.05.

Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetes mellitus (diagnosed by the physician)
* Score \>3 on Michigan Neuropathy Screening Instrument-Questionnaire and score \>2 on MNSI-Physical Examination
* Diabetic peripheral neuropathy symptoms below the ankle (numbness, tingling, burning, sharp pain, increased sensitivity, etc.)

Exclusion Criteria:

* Presence of any other systemic disease rather than diabetes such as end-stage renal failure, uncontrolled hypertension, severe dyslipidemia, chronic liver disease, autoimmune disease, advanced chronic obstructive pulmonary disease, etc.
* Diabetic ulcer in either foot
* Total or partial amputation of lower extremities
* Active inflammations or other inflammatory neuropathies including chronic inflammatory demyelinating polyneuropathy, proximal diabetic neuropathy, chemotherapy-induced peripheral neuropathy, autonomic neuropathies, or other neuropathies not associated with DM such as B12 deficiency
* History of fracture, strain, history of trauma leading to nerve injuries in the last year.