cyrilzakka/clinical-trials huggingface dataset:
Visual Field Progression and RNFL Change After PreserFlo MicroShunt Implantation

The trabeculectomy is the gold standard in glaucoma surgery, nevertheless often postoperative interventions have to be done. (1),(2) The PreserFlo MicroShunt (Santen, Osaka, Japan) implantation occurs without critical steps of trabeculectomy. (3) According to a study a 20% eye pressure reduction was achieved in 53.9% of patients one year after PreserFlo MicroShunt implantation and the risk of postoperative hypotony was clearly minimized. (4) It has been shown that after trabeculectomy there is a stable development of visual fields in the first 3 months after surgery and then, despite adequate intraocular pressure reduction, visual fields deteriorate. (5) At the Klinikum Klagenfurt structural and functional changes after PreserFlo MicroShunt Implantation shall be evaluated.


Eligibility Criteria:
Inclusion Criteria:

* Patients with insufficient eye pressure control despite IOP (intraocular pressure)-lowering therapy
* Diagnosis of POAG (primary open angle glaucoma)
* Diagnosis of PEG (pseudoexfoliation glaucoma)
* Diagnosis of PDG (pigment dispersion glaucoma)
* Diagnosis of NTG (normal tension glaucoma)
* Agreement of patients to participate in the study

Exclusion Criteria:

* Previous glaucoma surgery
* Visual acuity of Nulla Lux
* Poor general condition
* Pregnancy
* Exudative macular degeneration
The Hematologic Impact of Umbilical Cord Milking Versus Deferred Cord Clamping in Premature Neonates.

Comparing the beneficial effect of cord milking versus deferred cord clamping in preterm neonates. A randomized controlled trial

Placental transfusion either by deferred cord clamping or umbilical cord milking became standard care and recommended management especially in preterm deliveries.1 In average, about 80 ml of blood was found to be transferred to the neoborn by one minute after birth.2 This additional blood can afford extra iron and blood volume giving the benefit of less iron deficiency anemia during the first year of life, less need for blood transfusion, less need for vasopressors and less intraventricular hemorrhage (IVH) by 50%.3 Placental transfusion with different techniques proved safety with no significant risks regarding postpartum hemorrhage, polycythemia, jaundice, Apgar score or admission rates.4 Our study aims to compare delayed cord clamping with umbilical cord milking as the best way for placental transfusion for preterm neonates.

Eligibility Criteria:
Inclusion Criteria:

• Gestational age 24 to 34+6 weeks

Exclusion Criteria:

* Category III CTG
* Monochorionic twins
* Significant antepartum hemorrhage
* IUGR or Rh incompatibility
Effectiveness of Self-posturotherapy on the Elimination of Residual Fragments After Treatment of Lower Calyx Urinary Stones by Extracorporeal Lithotripsy or Retrograde Flexible Ureteroscopy.

The main objective of this study is to evaluate the effectiveness of an auto posturotherapy technique on the RFS at three months of patients treated for lower calyceal urinary stones by extracorporeal lithotripsy (ECL) or retrograde flexible ureteroscopy.


Eligibility Criteria:
pré Inclusion Criteria:

* Patient having read and signed the consent form for participation in the study • Patient candidate for an intervention on a lower calyx stone \<15mm by LEC or URSS

Patients meeting all of the following criteria may be definitively included in the study:

* Patient treated by LEC, or patient treated by URSS and for whom the presence of lower calyceal fragments has been observed by endoscopy
* Absence of JJ stent (patients for whom a JJ stent was implanted after URSS or before LEC may be included as soon as it is removed)

Exclusion Criteria:

* Patients presenting one of the following criteria will not be included in the study:

  * Renal or ureteral malformation: ureteral stenosis, pyelo-ureteral junction syndrome, horseshoe kidney, para calyceal diverticulum, pelvic kidney.
  * LEC session interrupted due to treatment intolerance
  * Physical disability making posturotherapy impossible (particularly spinal, etc.), morbid obesity, major gastroesophageal reflux, heart or respiratory failure.
  * Balance disorder which would not allow self-posturotherapy to be carried out alone.
  * Patient under legal protection, under guardianship or under curatorship
  * Posturotherapy carried out while wearing a JJ probe
  * Posturotherapy carried out by a third party (physiotherapist or other)
  * Pregnant or breastfeeding patient
  * Patient not affiliated to the French social security system
  * Impossibility of providing the subject with informed information and/or giving written informed consent: dementia, psychosis, disorders of consciousness, non-French speaking patient
  * Treatment that may modify the clearance of fragments (beta blocker, diuretic, etc.)
  * Patient included in another therapeutic study protocol
Transluminal Attenuation Gradient Versus CT Fractional Flow Reserve

Coronary computed tomographic angiography (CCTA) has emerged as a non-invasive test, accurately evaluate anatomic coronary artery stenosis. However, anatomically-obstructive coronary stenosis by CCTA demonstrates an unreliable relationship to lesion-specific ischemia. Recently, with the advance of imaging reconstruction and analysis technique, several novel parameters computed from CCTA were suggested to have added value in determining the ischemia-causing coronary stenosis. In this study, diagnostic performance of transluminal attenuation gradient (TAG) and fractional flow reserve computed form CCTA (FFR-CCTA) for the presence of hemodynamically-significant coronary stenosis, as determined by fractional flow reserve (FFR).

Angiographically obtained fractional flow reserve (FFR) is a useful physiologic test for assessment of lesion-specific ischemia, and a valuable adjunct to anatomic assessment of coronary artery disease (CAD) as determined by invasive coronary angiography. However, the invasiveness and measuring difficulty of FFR make it unfamiliar to perform. Coronary computed tomographic angiography (CCTA) has emerged as a non-invasive test, accurately evaluate anatomic coronary artery stenosis. Although CCTA evaluation of CAD has been validated against invasive coronary angiography and intravascular ultrasound, anatomically-obstructive coronary stenosis by CCTA demonstrates an unreliable relationship to lesion-specific ischemia. Recently, with the advance of imaging reconstruction and analysis technique, several novel parameters computed from CCTA were suggested to have added value in determining the ischemia-causing coronary stenosis. In this study, diagnostic performance of transluminal attenuation gradient (TAG) and fractional flow reserve computed form CCTA (FFR-CCTA) for the presence of hemodynamically-significant coronary stenosis, as determined by FFR, will be compared to suggest best functional parameter noninvasively computed form CCTA.

Eligibility Criteria:
Inclusion Criteria:

* Age \>= 18 years old
* CCTA with \>=50% stenosis in a major coronary artery (\>=2.0 mm diameter)
* underwent invasive coronary angiography with FFR measurement

Exclusion Criteria:

* with CCTA of poor image quality
Safety Study of Kudiezi (a Chinese Medicine Injection) Used in Hospitals in China

This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in October 2011.

It was funded by China major scientific and technological specialized project for 'significant new formulation of new drugs'.

Kudiezi is kind of Chinese Medicine injection used for treating coronary heart disease and angina pectoris in many Chinese hospitals.

The purpose of this study is to determine adverse drug events or adverse drug reaction in large sample size 30,000 patients.

It is very common that Chinese Medicine Injection used in hospitals in mainland China. However safety problems rose in recent years. There could be many uncertain factors influence Chinese Medicine Injection in clinical practice.

Safety surveillance on Chinese Medicine injection is an important problem that needs to be sorted out through large sample observational study.

A registry study for Kudiezi injection safety surveillance with 30000 patients will be conducted from Jan.2012 to Dec.2015.

Eligibility criteria Patients who will use Kudiezi injection in selected hospitals

Data will be collected in four aspects by four different forms as following:

Form A (blue): demographic information Form B (yellow): adverse drug events/reaction Form C (white): extracted information from hospital information system and laboratory information system Form D (red): personalized information

Eligibility Criteria:
Inclusion Criteria:

* Patients using Kudiezi injection from 2012 to 2014

Exclusion Criteria:

* none
24h Continuous Intraocular Pressure (IOP) Monitoring vs Goldmann Applanation Tonometry

A study in which intraocular pressure (IOP) will be monitored over 24 hours using the SENSIMED Triggerfish® device and Goldmann applanation tonometry (GAT) in primary open angle glaucoma patients. The aim of this study is to investigate the comparability of diurnal IOP patterns emerging from SENSIMED Triggerfish and GAT.


Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent for the investigation
* Patients with primary open angle glaucoma (POAG), defined as open angle ≥ 30°, confirmed visual field loss (Mean Defect/Least Variance ≤ 2dB) and/or optic nerve head damage (cup disc ratio \> 0,5)
* Age 40-70 years at inclusion
* Not more than 4 diopters spherical equivalent on the study eye
* Not more than 2 diopters cylinder equivalent on the study eye
* For women of childbearing potential, adequate contraception
* Stable anti-glaucomatous therapy 4 weeks before the first 24-hour IOP assessment session and throughout the investigation

Exclusion Criteria:

* Patients not able to understand the character and individual consequences of the investigation
* Patients committed to an institution by virtue of an order issued either by the courts or by an authority
* Absence of or withdrawn informed consent
* Patients with contraindications for silicone contact lens wear
* Wear of full frame metallic glasses during SENSIMED Triggerfish monitoring
* Eye disorders including severe dry eye
* Eye disorders secondary to POAG
* Patient who have had ocular surgery within the last 3 months
* Corneal or conjunctival abnormality or irregularity hindering correct contact lens adaptation
* Pregnancy and lactation
* Allergy to oxybuprocaine (ocular anesthesia)
* Simultaneous participation in other clinical research
Neurofilaments for NEDA Assessing in MS

Goal is to evaluate the achievement of biological NEDA as demonstrated by a drop in neurofilament levels in MS patients commencing Alemtuzumab therapy as part of their MS management.

Primary

1. To evaluate the achievement of NEDA using blood and CSF neurofilaments in Alemtuzumab treated patients.

   Secondary
2. To assess prognosis at the end of the study based on neurofilament status.
3. To correlate neurofilament levels with clinical and MRI markers of disease activity.
4. To evaluate the effect of Alemtuzumab on the profile of other CSF, blood, urine, faeces biomarkers of inflammation, neurodegeneration, neuronal sprouting and synaptogenesis, treatment activity and metabolic activity.

Eligibility Criteria:
Inclusion Criteria:

1. Diagnosis of Relapsing Remitting Multiple Sclerosis (RRMS).
2. Age 18-55 years.
3. EDSS score between 0-5.5.
4. Commencing Alemtuzumab therapy at Neurology Infusion and Planned Investigation Unit, The Royal London Hospital, Ward 11D

Exclusion Criteria:

1. A diagnosis of Secondary Progressive MS (SPMS) or other forms of progressive MS.
2. Those unable to comply with study requirement
Photobiomodulation and Glass Ionomer Sealant as Complementary Treatment for Hypersensitivity in Molars With MIH

Introduction: Photobiomodulation (PBM) shows promising results for the complementary treatment of dentin hypersensitivity; however, few studies have evaluated this treatment specifically for teeth affected by molar incisor hypomineralization (MIH). The aim of this study was to assess the effects of photobiomodulation combined with glass ionomer sealant on hypersensitivity in molars with MIH. Methods: Forty-nine children six to twelve years of age with a molar affected by MIH (Grade 3, 4a or 4b) of the MIH-TNI (Treatment Needs Index) criteria were randomly allocated to two groups - Group 1 (control group) (n = 25): toothpaste with fluoride concentration ≥ 1000 ppm (Parts Per Million) twice per day, glass ionomer sealant and simulated PBM; Group 2 (study group) (n = 24): toothpaste with fluoride concentration ≥ 1000 ppm twice per day, glass ionomer sealant and active PBM. Data collection involved the record of MIH, Schiff cold air sensitivity scale (SCASS), visual analog scale (VAS), the simplified oral hygiene index (OHI) and the colour, coverage, caries (CCC) sealant evaluation system. Results: Forty-six children completed the study and were evaluated one month after the onset of treatment. A significant reduction in the Schiff Cold Air Sensitivity Scale (SCASS) was found only in the active PBM group. Reductions in Visual Analog Scale (VAS) scores were observed in both groups, with a statistically significant difference between the groups at the 48-hour and 1-month assessments following PBM application. Similarly, significant differences in the Oral Hygiene Index (OHI) were found only in the active PBM group when comparing baseline values to those after 48 hours and one month. A significant difference between the groups was noted for sealant durability at one month, with better scores in the active PBM group. Conclusion: The administration of photobiomodulation combined with glass ionomer cement improves hypersensitivity and oral hygiene in molars with MIH. The improvement in oral hygiene increases the quantity of remaining sealant on teeth with MIH.


Eligibility Criteria:
Inclusion Criteria:

* Healthy individuals (ASA I);
* Children aged 6 to 12 years with at least one permanent first molar affected by MIH grades 3 and 4 (a and b) according to the MIH Treatment Needs Index (TNI), and with hypersensitivity score 2 or higher on the visual analog scale (VAS);
* Molars with fractures and without pulp involvement or active caries;
* Molars with eruption of the entire occlusal surface and at least one-third of the vestibular surface.

Exclusion Criteria:

* Molars with hypersensitivity caused by carious lesions were excluded to avoid diagnostic confusion with pulpitis;
* Teeth that had undergone desensitizing treatments in the previous three months, except for daily use toothpaste;
* Those with fixed orthodontic appliances; Patients who experienced discomfort during the hypersensitivity test, or those unable to tolerate the procedure were also excluded.
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients

This study is designed to determine whether maximal diaphragm thickening fraction measured by ultrasound during volitional maximal inspiratory efforts is a valid measure of diaphragm function in mechanically ventilated patients.

Classically, assessing diaphragm function requires direct measurements of transdaphragmatic pressure generation. A critical requirement for valid measurements is a maximal volitional patient effort. An alternative is to standardize the stimulus to the diaphragm using magnetic twitch stimulation fo the phrenic nerve. This is the gold standard technique for diaphragm function measurement in the respiratory physiology laboratory.

Twitch measurements require technical expertise and expensive equipment; this technique is therefore basically limited to the laboratory. Bedside ultrasonography has been proposed as a method for measuring diaphragm function by assessing the thickening of the muscle during a maximal inspiratory effort. In order to achieve a maximal volitional effort in mechanically ventilated patients, several methods may be employed: coached maximal efforts, coached sniffing, and transient airway occlusion to stimulate respiratory drive (Marini maneuver).

The investigators are evaluating the validity of diaphragm functional assessment using bedside ultrasound in combination with coached efforts/sniffing/Marini maneuver against the gold standard technique: twitch transdiaphragmatic pressure.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients (≥ 18 years old) with acute respiratory failure receiving invasive mechanical ventilation via endotracheal tube or tracheostomy
* Patients who meet readiness-to-wean criteria (triggering the ventilator; FiO2 ≤ 50%; PEEP ≤ 8 cm H20; hemodynamic stability)

Exclusion Criteria:

* Contraindication to phrenic nerve stimulation (chest tube; cardiac pacemaker or implanted defibrillator; cervical implants; use of neuromuscular blocking agents within the 24 hours preceding the first diaphragm assessment (with the exception of succinylcholine used during rapid-sequence induction of anaesthesia for intubation); cervical spine injury; known pregnancy)
* Patients experiencing an acute exacerbation of an obstructive lung disease (chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis)
Effects of Workstation Ergonomics and Physiotherapy in Cervicogenic Headache.

Cervicogenic headache (CgH) is a distinct form of headache and accounts for 17.8% of all headaches and the prevalence rate is between 0.4% and 20%. A guide to health and safety in the office handbook by common wealth of Australia (2008) suggested the ergonomic guidance and interventions for preventing and treating musculoskeletal disorder (MSD) injuries in the office workers. Also, It has been estimated that 34% of US citizens receive some sort of physiotherapy for CgH each year. However, no studies have compared and investigated the combined and individual effects of workstation ergonomics, physiotherapy and patient education for improving cervicogenic headache and work ability in office workers.

Cervicogenic headache (CgH) is a distinct form of headache and accounts for 17.8% of all headaches and the prevalence rate is between 0.4% and 20%. A guide to health and safety in the office handbook by common wealth of Australia (2008) suggested the ergonomic guidance and interventions for preventing and treating musculoskeletal disorder (MSD) injuries in the office workers. Also, It has been estimated that 34% of US citizens receive some sort of physiotherapy for CgH each year. However, no studies have compared and investigated the combined and individual effects of workstation ergonomics, physiotherapy and patient education for improving cervicogenic headache and work ability in office workers.

Therefore, our study objective was intended to compare and investigate the combined and individual effects of workstation ergonomics, physiotherapy and patient education in improving cervicogenic headache and work ability in office workers. This randomized clinical trial hypothesized that there is a difference in primary and secondary outcome measures between workstation ergonomics, physiotherapy and patient education for improving cervicogenic headache and work ability in office workers.

Eligibility Criteria:
Inclusion Criteria:

Patients aged between 18-60 years Working in the computer ≥ 32 hrs/week Suffering from Cervicogenic Headache (\>3 months) Pain intensity ≥3 on a numerical pain rating scale (NPRS), Cervicogenic Headache resulting from pain in the neck followed by headache, Limited neck movements, Neck muscle spasm, Consent to participate in the study

Exclusion Criteria:

Other primary headaches such as migraine and tension-type headaches (TTH), Whiplash injuries, Participants who show signs of the five 'D's' (dizziness, drop attacks, dysarthria, dysphagia, diplopia) Who have signs of the three 'N's (nystagmus, nausea, other neurological symptoms (cord compression or nerve root involvement), Contraindications to physio therapy (Congenital anomalies, tumor, degenerative and inflammatory arthritis, osteoporosis, dislocation, fractures, and steroid intake), Underwent previous head and neck surgeries, Had physiotherapy or other complementary therapies in the last three months
Radiotherapy Alternates Human Epidermal Growth Factor 2 (Her2) Expression in Human Breast Cancer

Based on fundamental study （in Vitro and in Vivo, Pro. Jianjian Li）， Her2 expression would be changed from negative to positive by cancer irradiation with liner-accelerator at dose 6GY or up. The propose of this study is to reveal the irradiation result on Her2 expression in human breast cancer.


Eligibility Criteria:
Inclusion Criteria:

* histological confirmed advanced breast cancer
* cancer sample can be obtained by fine needle biopsy
* IHC and FISH confirmed Her2 negative
* radiotherapy indication for local residual cancer

Exclusion Criteria:

* no radiotherapy indication
* patient refuse
Resisted Training in Runners

INTRODUCTION: Sprint training and resisted sprint training with sled has generated interest in the scientific literature due to its potential to improve performance, different studies have shown that incorporating strength training and sprints into studies have shown that the incorporation of strength and sprint training into the training programmes of long-distance runners can have significant training programmes for long-distance runners can have significant effects on running economy, anaerobic capacity of the runners and the anaerobic capacity of athletes, along with various neuromuscular adaptations. Despite these findings, the application of sprint and resisted sprint training with dragging in middle-distance and long-distance runners has been and long-distance runners has been scarcely studied, with most studies focusing on sprinters and athletes from team sports and sprinters, leaving a gap in the understanding of how these methods can influence distance runners. Along with how the intensity of external external loads affect this type of work and the influence on key kinetic variables such as vertical oscillation, contact time with the oscillation, ground contact time and muscle stiffness in this specific population.

PURPOSE: Analyse the effects that sprint training and resisted sprint training can have on running economy, force production, speed and various kinetics variables such as vertical oscillation, contact time, speed and vertical oscillation, ground contact time and muscle stiffness. MATERIAL AND METHODS: A randomised, longitudinal, prospective, blinded, assessor-blinded clinical trial will be conducted. Different variables related to sports performance will be evaluated, such as maximum oxygen consumption, critical power, heart rate variability or kinetic variables, among others.

kinetic variables among others. The evaluation will be carried out before the application of the training intervention and after two months. The study will be conducted with runners recruited through athletics clubs in the region of Cadiz, being randomly assigned a system of numerical tables using a computer programme between the sprint group (n=40) and the resisted sprint group (n=40). Both groups will perform two training sessions training sessions for eight weeks, consisting of sprint or resisted sprint repetitions based on the assigned group.

KEY WORDS: athletics, runners, resisted training, sprint.


Eligibility Criteria:
Inclusion Criteria:

* At least 2 years of training experience as a runner.
* Do more than 30 kilometres per week.
* Perform at least 3 training sessions per week.
* Have competed in a 10km race or longer distance in the last 6 months.
* Be between 18 and 35 years old.
* Availability to attend the proposed training sessions.

Exclusion Criteria:

* Have a musculoskeletal injury or have had a musculoskeletal injury in the 6 months prior to the start of the study.
* Have chronic diseases.
* Have a BMI over 24.9.
* Combine training and competition in other disciplines other than running.