cyrilzakka/clinical-trials huggingface dataset:
Eye Drops Study for Myopia Control in Schoolchildren

The myopia prevalence in schoolchildren is high in Taiwan. The myopia progression is fast in children and often associated high myopia in later life. This prospective and randomized study to investigate the effect of myopia control in myopic children with ultra low concentrations of atropine eye drops and/or low concentrations of anti-allergic and inflammatory eye drops.

Myopia onset earlier in children who would suffer a high degree of myopia in the future adulthood.and higher risk for retinal detachment, macular degeneration, and even blindness. In Taiwan, myopia macular degeneration is the first place of irreversible blind cause in the elderly. The evidence based medicine shows atropine is the most effective treatment for the progression of myopia so far, but the side effects including photophobia and near blurred vision often disturbing patients and resulting poor compliance and high drop-out rate.

Recently, the studies from Taiwan and Singapore showed that low concentrations of atropine (0.05% or 0.01%) can effectively inhibit the myopia progression, reduce the symptoms of photophobia, and to achieve favorable myopia control. Previous study found that myopia and allergic conjunctivitis and inflammation were related. The investigators designed a prospective and randomized study to investigate the effect of myopia control in myopic children with ultra low concentrations of atropine eye drops and/or low concentrations of anti-allergic and inflammatory eye drops. Due to environmental factors such as near work, after school class and outdoor activity are also great associated with myopia, the questionnaires also are collected in this study.

Eligibility Criteria:
Inclusion Criteria:

* Myopia diagnosed with the spherical equivalent refraction at least -0.5 diopter (D)
* Must be able to use eye drops

Exclusion Criteria:

* astigmatism -1.50 D or greater
* strabismus
* amblyopia
* cataract
* glaucoma
* any ocular diseases ocular surgery
* history of systemic diseases (ex. asthma, heart disease...)
* contact lenses user
* orthokeratology user
CoQuit Study for Smoking Cessation

This study investigates the feasibility of a cognitive dissonance-based mobile app for smoking cessation (CDI). Cognitive dissonance refers to the conflict between beliefs and behaviors; interventions are designed to promote this conflict to motivate people to change their behavior. Recent research has demonstrated the efficacy and potential of using cognitive dissonance interventions for a wide range of health and behavioral problems including smoking cessation. This study will develop an initial version of the CDI mobile app and evaluate the app in an evaluation study with 60 adult smokers.

A group of 60 adult smokers will use and evaluate the initial version of the CoQuit app. All participants will be recruited through social media; they will be screened and consented online. After enrolling, participants will receive a link to the baseline survey which asks about past and current tobacco use, nicotine dependence, motivation to quit, cognitive dissonance and demographic information. All participants will then be assigned to an online support group of 5 or 6 people. The group will receive simultaneous invites to the app so they can move through the 25 day program together. The app contains short videos of a CoQuit facilitator who presents instructions for specific tasks, such as writing a brief letter to a friend or family member explaining the decision to stop smoking. Participants will make videos of themselves related to these activities and post the videos within the app where they can be viewed by other members of the group. All participants will complete a six weeks post baseline online assessment asking about past and current tobacco use, quit attempts, and thoughts about navigation, ease of program use, and possible improvements to the app.

Eligibility Criteria:
Inclusion Criteria:

* Age 18 or older
* Self-reported daily smoking
* Having a valid home mailing address
* English speaking
* Access to a smartphone with video capability and internet
* Not currently participating in any tobacco cessation programs
* Expressed desire to quit smoking

Exclusion Criteria:

-
Correct Use of Sequential Formoterol and Budesonide Inhaler Capsule Treatment Via Aerolizer and Patient Satisfaction in Asthmatics

This study will evaluate the correct use of sequential formoterol and budesonide inhaler capsule treatment via Aerolizer and patient satisfaction in adult asthmatics.


Eligibility Criteria:
Inclusion Criteria:

* Moderate persistent asthmatic patients.
* No previous Aerolizer experience.

Exclusion Criteria:

* Life-threatening asthma: A subject must not have life-threatening asthma as a history of significant asthma episode(s)requiring intubation associated with hypercapnia, respiratory arrest or hypoxic seizures, or asthma-related syncopal episode(s).
* Worsening of asthma: A subject must not have experienced a worsening of asthma which involved a hospitalization within 6 months of screening, or an emergency room visit three or more times in the past 6 months, or use of oral corticosteroids for worsening asthma within 3 months of screening.
* Unstable asthma: During screening period, a patient requires the use of \>8 puffs/day of salbutamol 100 mcg per actuation pMDI on two consecutive days.
* A subject must not have had an upper respiratory tract infection within 4 weeks of screening.
* FEV1\< 60% at screening.

Other protocol-defined inclusion/exclusion criteria may apply.
Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation

The purpose of this study is to examine the influence of premedication drugs Atropin, Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac output in term and preterm newborn infants. Two different protocols of premedication are compared.

Influence of the following procedures will be examined:

* Application of Atropin
* Application of Fentanyl
* Application of Mivacurium
* possible desaturation and / or bradycardia during intubation attempts
* restoration of arterial oxygen saturation and / or heart rate after succesful intubation

We aim to examine the change of the following parameters by the use of electrical cardiometry:

* stroke volume
* cardiac output

We compare two different premedication protocols and we evaluate the impact of these protocol on the time needed for intubation and on intubation difficulties .

Eligibility Criteria:
Inclusion Criteria:

* newborn infant below 44 weeks postmenstrual age
* indication for elective or semi-elective endotracheal Intubation
* parental informed consent

Exclusion Criteria:

* emergency intubation
Therapist Adherence to Cognitive-behavioral Therapy

An observational web-based survey on therapist adherence to evidence-based cognitive-behavioral therapy (CBT) in the perspective of their patients with depression or anxiety disorders in psychiatric outpatient care in Stockholm, Sweden. Following completion of CBT, participants respond to questions including their age, gender, education, whether they have improved, whether they considered treatment helpful, and an instrument measuring therapist adherence to CBT procedures (e.g., setting agenda, follow up on home assignments) and CBT techniques (e.g., exposure, cognitive restructuring). The purpose of the study is to contribute to quality assurance of CBT in Stockholm Health Care Services.


Eligibility Criteria:
Inclusion Criteria:

* A primary diagnosis of major depressive disorder, social anxiety disorder, panic disorder, agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, or illness anxiety disorder
* 18 years of age or older
* Just completed individual cognitive-behavioral therapy in psychiatric outpatient care in Stockholm, Sweden

Exclusion Criteria:

* None
Study to Evaluate the Effectiveness of Rotarix™ Against Severe Gastroenteritis Among Hospitalized Children in Brazil

The purpose of this study is to estimate the effectiveness of 2 doses of Rotarix™ vaccination in preventing rotavirus severe gastroenteritis among children hospitalized in Belem area, Brazil.

The study will be comprised of two parts: Case-control study and Rotavirus strain surveillance.

Eligibility Criteria:
Inclusion Criteria:

For cases:

* A male or female child born after 6 March 2006 and at least 12 weeks of age.
* Subject admitted to the study clinics/hospitals for severe gastroenteritis during the study period.
* Onset of severe gastroenteritis ≤ 14 days prior to admission.
* Laboratory confirmed rotavirus positive stool sample at hospital admission or during the first 48 hours of hospitalization.
* Written informed consent obtained from the parent or guardian of the subject.

For controls:

* Admitted for non-gastroenteritis causes at the same clinic/hospital as the case.
* Living in the same neighbourhood as the case for at least three consecutive months without any symptoms of gastroenteritis or severe gastroenteritis on the day of interview of his/ her parents/ guardians.
* Being born within +- 2 weeks from the date of birth of the case. If the number required is not available, then the range would be extended to +- 4 weeks, and ultimately up to +- 6 weeks for hospital controls. For neighbourhood controls, the range may be extended to +- 8 weeks.
* Written informed consent obtained from the parent or guardian of the child.

Exclusion Criteria:

For cases:

* Subject has previously participated as case or control in this study.
* Onset of severe gastroenteritis \> 48 hours after admission to the hospital (nosocomial infections).

For controls:

* For hospital controls: Child who has symptoms of gastroenteritis during current hospitalization or on the day of interview of his/her parent or guardian or for neighbourhood controls: Child who has symptoms of gastroenteritis or severe gastroenteritis on the day of interview of his/her parent or guardian.
* Exclude children with the following vaccine preventable diseases: measles, mumps, rubella, diphtheria, pertussis, tetanus, tuberculosis, invasive Haemophilus influenzae type B (Hib) infections (meningitis, bacteraemia, septic arthritis, cellulitis, and epiglottitis) and hepatitis B.
* Child has participated in the past as a case or control in this study.
* Child living in the same house as the case
Chart Review: Comparing the Position and Tilt of Dental Implants Versus Those of Natural Teeth

Background:

When placing a dental implant, it is not always possible to place it exactly in the same position as the tooth that it replaced. That might be because of how the gums and mouth are shaped, since some bone is always lost after a tooth is extracted. Researchers want to study the records of people who have had dental implants. They want to check to see how much difference there is between how the implant is positioned and how the same tooth on the other side is positioned. They also want to compare how the implant is positioned compared to the tooth it replaced, when that is possible in the dental record.

Study design:

This study will not enroll any participants. The researchers will search the database of patient records at the study clinic to find people who have had dental implants of a single molar tooth. Then they will look at them to find records that include good images that they can use to compare the implant and tooth positions.

Researchers will then analyze the findings and write a review article.

This is a retrospective chart review. Specifically, the clinic e-chart system will be used to locate patients who received implant surgery. E-charts from January 1, 2016, to January 6, 2025, with pre- and post-implant surgery tomography (CBCT) documentation will be identified and used for this study.

Demographic and clinical data (age, sex, systemic conditions, implant details and surgical treatment outcomes) related to these cases will be collected. Radiographic measurements will include the following:

* On tomography: 1. Buccolingual axial inclination of natural molars and implants. 2. Mesiodistal axial inclination of natural molars and implants. 3. Presence/absence of fenestration and/or dehiscence around implants 4. Proximity to mandibular canal and/or foramen mentale
* On Panoramic radiograph: Mesiodistal axial inclination of natural molars and implants.

Eligibility Criteria:
Inclusion Criteria:

* Patients with mandibular molar implant placement.
* Presence of contralateral natural mandibular first, second molars or both.
* Availability of pre-extraction CBCT scans of the corresponding or contralateral mandibular molar tooth or panoramic radiographs for mesiodistal angulation.
* Availability of post-implant CBCT scans or panoramic radiographs for mesiodistal angulation

Exclusion Criteria:

* Incomplete or low-quality CBCT scans.
* History of mandibular trauma or pathologies altering tooth or implant alignment.
* History of reconstructive mandibular surgery in the implant region.
* History of periapical pathology
CT-guided Pudendal Nerve Cryoneurolysis for Palliation of Malignancy-induced Pelvic Pain

We want to study if a new treatment called "CT-guided bilateral pudendal nerve cryoneurolysis" can help people with severe and long-lasting pain in the pelvic area caused by cancer. We will closely follow and observe patients who undergo this treatment to see if it works well, what results it gives, and if there are any problems or side effects. "Percutaneous image-guided cryoneurolysis" involves using very cold temperatures to treat the nerves causing the pain. This method has been found to provide longer pain relief compared to injections or catheters, and it also has a lower risk of certain complications.

We are conducting a study to assess the effectiveness of two different treatments for severe and persistent pelvic pain caused by cancer. The first treatment, known as "CT-guided bilateral pudendal nerve cryoneurolysis," involves using advanced imaging technology to precisely target and freeze the pudendal nerves, which are responsible for transmitting pain signals. By closely monitoring patients who receive this treatment, we aim to evaluate its efficacy, outcomes, and potential side effects.

On the other hand, the second treatment approach, referred to as "Percutaneous image-guided cryoneurolysis," focuses on using extremely cold temperatures to alleviate pain originating from the pudendal nerves. This method has demonstrated extended pain relief compared to alternatives like injections or catheters. Additionally, it presents a lower risk of certain complications. Through our study, we seek to gain insights into the effectiveness and safety of both treatment methods, enhancing our understanding of how to address the challenging issue of cancer-related pelvic pain.

The study will enroll patients who are dealing with severe and persistent pelvic pain from cancer. All patients will undergo the CT-guided bilateral pudendal nerve cryoneurolysis first type of treatment and if it is not effective in relieving the pain, they will be offered to undergo the second treatment called Percutaneous image-guided cryoneurolysis.

Both of these treatments are done as standard of care. This research study will not alter standard of care. Subjects will only be enrolled into this study if they are already undergoing CT-guided bilateral pudendal nerve cryoneurolysis followed up with Percutaneous image-guided cryoneurolysis, as needed. This is a prospective study of these two treatments following patient outcomes.


Eligibility Criteria:
Inclusion Criteria:

Those already scheduled for a CT-guided bilateral pudendal nerve cryoneurolysis as standard of care Age ≥18 years old Active or history of pelvic cancer malignancy Poor pelvic pain control with current therapy (pain from cancer malignancy) Pain in distribution of the pudendal (genital) nerves from cancer malignancy

Exclusion Criteria:

Pain in distribution of the pudendal nerves from nonmalignant etiology Patients with pain from other medical conditions besides cancer/cancer malignancy will not be included (cancer-related pain from cancer malignancy in the genital region is considered).
Metabolic Availability of Lysine From White Maize

Our objective is to determine the metabolic availability of Lysine in white maize using the indicator amino acid oxidation (IAAO) technique in adult men.

Our objective is to determine the metabolic availability of Lysine in white maize. 7 young, healthy, male adults will receive graded levels (29, 37,46 and 54%) of lysine requirement of 35 mg/kg/d as a crystalline AA mixture and a porridge of white cornmeal protein respectively.

Eligibility Criteria:
Inclusion Criteria:

* Healthy Adult males (20-49 years old)

Exclusion Criteria:

* A history of recent weight loss or illness
* Use of any medication at the time of entry into the study
Insulin Therapy and Falls Due to Orthostatic Hypotension

In the proposed study, the investigators examine in older adults with Type 2 diabetes the impact of beginning insulin therapy on the orthostatic drop in blood pressure as well as the response of arterial blood pressure and Doppler measures of cerebral blood flow during upright tilt. The investigators hypothesize that in older adults with Type 2 diabetes, the cardiovascular effects of insulin would precipitate or worsen orthostatic intolerance not present at baseline.

Before and 2 weeks after the start of standard insulin therapy several tests will be done:

* orthostatic hypotension will be tested for with 3 orthostatic maneuvers
* vasovagal syncope will be tested with 2 tilt table tests, one augmented with 400ug of nitroglycerin
* MCA velocity will be measured with a transcranial doppler
* Heart Rate and Blood Pressure will be measured throughout the test with a Finometer and Power Lab on a beat to beat basis

Eligibility Criteria:
Inclusion Criteria:

* All subjects must be 65 years of age or older
* All must have been diagnosed with Type 2 diabetes for at least 5 years
* All subjects must be insulin-naïve on recruitment
* All subjects must be eligible to start insulin therapy (long or intermediate acting) as determined by their diabetologist

Exclusion Criteria:

* Anemia, as determined by serum hematocrit
* Abnormal liver function tests
* Elevated creatinine
* Smoker
* Musculoskeletal or neurological condition that would preclude tilt table testing or orthostatic vitals
Helmet Ventilation During Self-Paced Walking Test

The aim of this study is to investigate the use helmet ventilation (HV) in walking test and analysis of effect patients with COPD.

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation with chronic inflammation of the respiratory system. Symptoms of COPD may contribute to activity restriction, deconditioning and exercise intolerance. Non-invasive positive pressure ventilation (NIPPV) has been shown to improve exercise intolerance and health-related quality of life in patients with severe COPD. Helmet ventilation (HV) is a new option for NIPPV to alternative to nasal or face mask. A study which published on JAMA demonstrated the feasibility and benefits of HV. The aim of this study is to investigate the use helmet ventilation (HV) in walking test and analysis of effect patients with COPD.

Eligibility Criteria:
Inclusion Criteria:

* Patents with COPD who confirm by pulmonary function test

Exclusion Criteria:

* COPD AE within 3 months
* Diagnosed neuromuscular disease
* Unable to perform 6-MWT
Treatment for Men Who Are Abusive to Their Partners

This study will develop an individual behavior therapy for men who are violent toward their partners and will compare the therapy to standard group treatment.

To date, treatment interventions for domestic abuse perpetrators have been conducted almost exclusively in groups. However, the efficacy of such treatments relative to no treatment has not been thoroughly evaluated. Evidence suggests that individual treatments may be more effective than group treatments. This study will combine motivational enhancement therapy with cognitive and behavior change techniques to treat men who abuse their partners.

This study will be conducted in two phases. In Phase 1, an individual cognitive behavior therapy (ICBT) manual will be constructed. During Phase 2, participants will be randomly assigned to receive either 16 sessions of ICBT or 16 sessions of standard group therapy. Data on abusive behavior outcomes and secondary treatment targets will be collected from participants and their partners every 3 months for 1 year after the study.

Eligibility Criteria:
Inclusion Criteria:

* Involved in male-to-female physical aggression in the past 12 months or has a history of severe male-to-female aggression in a relationship
* Current involvement in a primary intimate relationship (cohabiting, dating, or married) for at least 6 months, with partner contact at least once per week
* Willingness to provide written consent for partner contact
* Partner provides verbal assent for the use of information during an initial phone interview and agrees to be re-contacted for scheduled follow-up interviews

Exclusion Criteria:

* Psychotic symptoms or severe mood disorder
* Mental retardation, autism, dementia, delirium, catatonia, or other severe cognitive disorders
* Severe head trauma in the past two years
* Seizure disorder
* Current diagnosis of alcohol dependence or drug dependence. Participants must be in remission for at least 6 months if a past diagnosis is present.