cyrilzakka/clinical-trials huggingface dataset:
The Functional Magnetic Resonance Imaging Study on the Processing of Acute Pain and Cognition Among Perimenopause Women

There lacks effective early screen system for the migraine-susceptible women during the peri-menopause period. The processing of acute pain and cognition as well as the underling functional magnetic resonance imaging (fMRI) features are suitable for screening pain-susceptible individual. However, there is no study on this issue among the large sample peri-menopause women. The investigators thus designed the current trial to investigate the processing of acute pain and cognition as well as the underling featured functional magnetic resonance imaging (fMRI).The investigators will combine pain behavior,cognitive task, fMRI analysis, psychophysiological interaction (PPI) and suitable statistical package to investigate the relationship between the above mentioned features and the occurrence of migraine and then test the efficacy of these features in predicting migraine development. The investigators will then try to establish the screening system for migraine-susceptible individuals in peri-menopause women.

Although the prevalence of migraine is very high during peri-menopause period, there exist significant individual differences in whether developing migraine among this population. However, there still lacks effective early screen system for the migraine- susceptible women during the peri-menopause period. Individual acute pain processing and its interaction with cognition as well as the underling featured functional magnetic resonance imaging (fMRI) are suitable for screening pain-susceptible individual. Actually, the featured acute pain processing and its interaction with cognition as well as fMRI alterations were reported in two previous small sample trials among pre-menopause population, however, there is no similar study on large sample peri-menopause women. The investigators previously reported abnormal acute pain processing and decreased cognition in the experimental peri-menopause rats as well as peri-menopause women with migraine. The investigators thus raised the current hypothesis that the acute pain processing and its interaction with cognition as well as the underling featured functional magnetic resonance imaging (fMRI) are usable for screening migraine-susceptible individuals among peri-menopause women. In the current project, The investigators will combine pain behavior,cognitive task, fMRI analysis, psychophysiological interaction (PPI) and suitable statistical package to investigated the relationship between the above mentioned features and the occurrence of migraine and then test the efficacy of these features in predicting migraine development. The investigators will then try to establish the screening system for migraine-susceptible individuals in peri-menopause women.

Eligibility Criteria:
Inclusion Criteria:

* 25 years old or above
* Healthy women

Exclusion Criteria:

* Those with history of present illness
* Past history of significant neurological and psychiatric disorders or MRI contraindication
Endoleak Repair Guided by Navigation Technology

The study is aimed at investigating whether repair of endoleak type II can be improved by adding navigation technology. Can this technology increase precision by guiding the needle that punctures through the skin as used during the repair procedure? Can the procedure logistics be improved by using navigation technology instead of computed tomography (CT) guidance of the needle puncture? Parameters logged during the procedure:

* was the needle placement successful?
* number of needle punctures?
* time used on guidance procedure
* X-ray exposure dose


Eligibility Criteria:
Inclusion Criteria:

* detected endoleak

Exclusion Criteria:

* n/a
Symbiotic Yogurt, Calcium Absorption and Bone Health in Young Adult Women

Prebiotics have been linked to increased calcium absorption in animal and human studies (particularly in adolescents and in premenopausal women). Similarly, probiotics have been found to benefit calcium homeostasis in pregnant women, and to promote bio-mineralization in animal models. The effect of symbiotic on calcium absorption has been tested in rats, but not in human studies. The primary objective of this study is to investigate the effect of daily consumption of a functional symbiotic yogurt containing inulin and Lactobacillus rhamnosus compared to a control yogurt, on calcium absorption in young adult women. A secondary objective is to relate changes in calcium absorption following yogurt consumption, with calcium metabolism, vitamin D status, bone mass, calcium intake and overall composition of habitual diet.

A potential strategy to reduce the risk of osteoporosis later in life is to promote optimal bone mass during early adulthood by including in the diet functional foods that maximize the efficiency of calcium absorption. This approach is specially important in women because of their greater risk for osteoporosis than men. In this study, we hypothesized that the daily consumption of a yogurt containing inulin and Lactobacillus rhamnosus (symbiotic yogurt) increases the efficiency of calcium absorption in young adult women when compared to daily consumption of a yogurt of similar composition but without prebiotic or probiotic (control yogurt). Subjects in this study will be randomly assigned to consume daily the symbiotic yogurt or the control yogurt during two 3-week periods with a wash-out period of 3-weeks, in a cross-over design. Calcium absorption will be measured by stable calcium isotope methodology. Bone mass (BMD, BMC) will be measured by dual-Y ray absorptiometry. Serum intact parathyroid hormone, 25-hydroxyvitamin D and dietary intake will be measured by conventional methods.

Eligibility Criteria:
Inclusion Criteria:

* ages 18 to 35 years
* generally healthy

Exclusion Criteria:

* pregnancy/lactation
* BMI \<18,5 kg/m2
* BMI\> 29 kg/m2
* metabolic disorders, bone, liver or kidney disease that may affect calcium metabolism
* smoking
Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia

This research trial studies the shotgun sequencing of blood samples in diagnosing febrile neutropenia in patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help identify pathogens and accurately diagnose infections such as febrile neutropenia.

PRIMARY OBJECTIVES:

I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care diagnostics in the detection of pathogens in patients with febrile neutropenia.

SECONDARY OBJECTIVES:

I. To establish a microbiological diagnosis with known or unknown pathogens in patients in whom standard care failed to yield a pathogenic diagnosis.

OUTLINE:

Patients undergo collection of blood samples before and during the episode of febrile neutropenia for up to 6 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Patients with febrile neutropenia
* A primary diagnosis of acute myeloid leukemia (AML)

Exclusion Criteria:

* Prior history of febrile neutropenia
Effect of Prescribed Cardiac Rehabilitation in Patients With Advanced Heart Failure or Ventricular Assist Device

This trial will evaluate the effect of prescribed exercise training on quality of life and exercise capacity of patients with advanced heart failure or after ventricular assist device implantation. Furthermore, clinical, laboratory and echocardiographic markers of heart failure, rehospitalization rates and cost-effectiveness will be assessed.


Eligibility Criteria:
Inclusion Criteria:

* age \>17 years
* written informed consent
* chronic end-stage systolic heart failure with or without ventricular assist device
* clinically stable for at least 6 weeks
* prescription of cardiac rehabilitation

Exclusion Criteria:

* addictions or other illnesses that impact the ability to understand the nature, scope and consequences of the trial
* lack of knowledge of German to fully understand study information
* pregnancy, pre-menopausal women
* participation in the rehabilitation program \< 80%
* contraindications of cardiopulmonary exercise testing on an ergometer
Impact of Fatigue on Jumping Performance

The purpose of this study will be to determine the effects of a 2-minute single limb lateral step-down fatigue test versus a 30 second side hop test on single limb forward hop distance.

Current methods to induce fatigue often incorporate equipment not available in all clinical settings or include tasks that are difficult to standardize. One of the tests to fatigue the leg muscles is the leg extensor fatigue test using a unilateral weight machine. There are drawbacks to this testing including the clinician having access to the equipment, testing only fatigued a single muscle group, and it is less sport/task specific compared to jump testing. Our previous work has incorporated the use of a side hop task that is performed by hopping over two lines 40 cm apart for 30 seconds. While this does induce fatigue and decreases single leg forward hop performance the overall decrease was relatively small (\<10 cm). It is likely necessary to induce a greater amount of fatigue; thus further limiting single leg forward hop performance.

Eligibility Criteria:
Inclusion Criteria:

* No history of knee surgery
* Tegner score \>5

Exclusion Criteria:

* Participants with traumatic spine or lower extremity injury within past 6 months
* Participants who are unable to give consent or are unable to understand procedures of experiment
Plaque Stabilization and Restoration by Bioresorbable Vascular Scaffold

The aim of the study is to assess if implantation of a bioresorbable vascular scaffold (BVS) for intermediate coronary lesions with morphological signs of vulnerable plaque in patients prone for acute coronary syndromes (ACS) will stabilize the plaque, improve natural vasomotion and increase vascular diameter.


Eligibility Criteria:
Inclusion Criteria:

* Symptomatic patients between the age of 18 and 80 years
* Morise Risk score of ≥9 (intermediate or high risk) but no proven ischemia (no positive troponin or ST-elevation)
* Intermediate coronary lesion on CT scan (50-70% based on CT estimate) and a plaque with at least two of the following vulnerability criteria: Napkin ring sign, positive remodeling, low attenuation and spotty calcification
* FFR negative lesion at coronary angiogram
* Vessel diameter ≥2.5 mm on visual estimate
* GFR ≥ 45mL/min/1.73m².

Exclusion Criteria:

* High calcium score on CT scan preventing adequate evaluation of the coronary lesion.
* Lesions located in a coronary vessels previously stented.
* Lesions located at a bifurcation
* lesions involving an epicardial side branch ≥2 mm in diameter by visual assessment
* the presence of thrombus or another clinically significant stenosis in the target vessel.
* Left main (\>50%) or known three vessel disease.
* Patients presenting with acute myocardial infarction, unstable arrhythmias, or patients who have a left ventricular ejection fraction \<30%
* Intolerance to Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Heparine or Everolimus and known true anaphylaxis to prior contrast media or known bleeding diathesis or known coagulopathy.
* Planned elective surgical procedure necessitating interruption of dual antiplatelet therapy during the first 6 months after inclusion.
* History of stent thrombosis
* Malignancies or other comorbidity with a life expectancy of less than one year or that may result in protocol noncompliance
* Pregnancy (present, suspected or planned) or positive pregnancy test (in women with childbearing potential a negative pregnancy test is mandatory)
Non-invasive Monitoring and Serum Marker Study in Children With Cerebral Edema

Purpose of the study：This study aimed to evaluate the clinical significance of serum SUR1, TRPM4 and MMP-9 in the diagnosis of cerebral edema in children with cerebral edema admitted to PICU by comparing them with CT results and perturbation coefficients, so as to provide biological indicators for clinical diagnosis of cerebral edema and provide targets for the treatment of cerebral edema in various diseases.

Early and efficient use of various measures to control and monitor peripheral cerebral edema and intracranial pressure, timely and accurate adjustment of treatment plan to reduce the degree of cerebral edema and reduce intracranial pressure, can significantly improve the development of the disease and prognosis recovery. At present, the clinical diagnosis of cerebral edema is mainly through clinical manifestations and imaging examinations, and there is a lack of corresponding biological examination methods.Purpose of the study：1.By analyzing the correlation between serum SUR1, TRPM4, MMP-9 and the electromagnetic disturbance coefficient, cranial CT results, Glasgow coma score, S100-β, NSE and prognostic score at 3 months of discharge, the clinical value of serum SUR1, TRPM4, MMP-9 and perturbation coefficient in the diagnosis, intracranial pressure monitoring, condition assessment and prognosis judgment of cerebral edema in children was explored.2.By analyzing the changes of the above indicators in various children with cerebral edema admitted to PICU, the types of cerebral edema and the cellular and molecular mechanisms of cerebral edema caused by different diseases were explored.

Eligibility Criteria:
Inclusion Criteria:

* Age 1-18 years old, male or female
* Diagnosed with cerebral contusion/cerebral hemorrhage/intracranial tumor postoperative / intracranial infection/septic encephalopathy/metabolic encephalopathy.
* The research purpose, significance, risks, benefits, and informed consent of patients and their families to the study.

Exclusion Criteria:

* Critically ill and not suitable for research.
* Those who are allergic to electrode sheets and do not cooperate.
* Age\> 18 years old or \< 1 month.
* Failure to obtain written permission from the guardian.
A Study in Healthy Volunteers to Assess the Effect of Different Types of Food on a Single-dose of JNJ-64417184 Administered as Tablets

The purpose of this study is to evaluate the effect of 5 different food conditions on the single dose pharmacokinetics (PK) of the JNJ-64417184 tablet formulation administered orally, using the PK after a high-fat meal as a reference, in healthy adult participants.


Eligibility Criteria:
Inclusion Criteria:

* Must have a body mass index (BMI); weight per height square between 18.0 and 30.0 kilogram per meter square (kg/m\^2), (extremes included), and body weight not less than 50.0 kg at screening
* Healthy on the basis of physical examination, medical and surgical history, and vital signs performed at screening. If there are abnormalities, the participant may be included only if the investigator judges the abnormalities to be not clinically significant or to be appropriate and reasonable for the population under study. This determination must be recorded in the participant's source documents and initialed by the investigator
* Must have a normal 12-lead electrocardiogram (ECG) (triplicate) at screening, including: normal sinus rhythm (heart rate between 45 and 100 beats per minute \[bpm\], extremes included); QT interval corrected for heart rate (QTc); QRS interval less than (\<) 120 milliseconds (ms); PR interval less than or equals to \<= 200 ms. If the results of the ECG are outside the normal ranges, the subject may be included only if the investigator judges the deviations from normal ECG to be not clinically significant or to be appropriate and reasonable for the population under study. This determination must be recorded in the subject's source documents and initialed by the investigator
* Female participant must have a negative highly sensitive serum beta human chorionic gonadotropin (Beta-hCG) pregnancy test at screening and on Days -1 for each treatment period (except for postmenopausal female participants)
* Must not use nicotine-containing substances including tobacco products (example, cigarettes, e-cigarettes, cigars, chewing tobacco, gum, or patch) for at least 3 months prior to screening

Exclusion Criteria:

* Any evidence of heart block or bundle branch block at screening
* Current human immunodeficiency virus (HIV)-type 1 (HIV-1) or HIV-2 infection (confirmed by antibodies) at screening
* History of hepatitis A, B, or C infection, or current hepatitis A infection (confirmed by hepatitis A antibody immunoglobulin M \[IgM\]), or HBV infection (confirmed by hepatitis B surface antigen), or HCV infection (confirmed by HCV antibody) at screening
* A history of clinically significant drug allergy such as, but not limited to, sulfonamides and penicillins, or drug allergy witnessed in previous studies with experimental drugs
* Has previously been dosed with JNJ-64417184
Is Electrolyte Maintenance Solution Required in Low-Risk Children With Gastroenteritis?

The objective of this study is to clarify the current standard of care by determining if Electrolyte Maintenance Solution (EMS) is truly the optimal fluid to be used in low-risk children who present to an Emergency Department (ED) with \< 72 hours of vomiting or diarrhea.

Gastroenteritis remains a major cause of morbidity amongst Canadian children. The primary treatment focus revolves around the use of Oral Rehydration Therapy (ORT) to treat dehydration and replace intravascular volume. Since diarrheal disease in Canadian children usually results in mild dehydration and minimal sodium losses, the use of low sodium Electrolyte Maintenance Solutions (EMS) has become the standard of care. However, given that North American children infrequently develop severe dehydration, it is unclear if the routine use of EMS is justified. When pediatricians directly dispense EMS, 16 children need to be treated to prevent 1 unscheduled office visit, however the upper bound of the 95% confidence interval is an astounding 508 patients. In addition, EMS is considered by some to be prohibitively expensive, with 15% of pediatricians believing it to be too expensive for their patients to purchase. An additional 40% report that taste is a major barrier to consumption. As a result, oral fluid replenishment is often underutilized and IV rehydration employed instead. Our goal is to provide evidence to guide the selection of the optimal ORT fluids in low-risk children, thus increasing its use, enhancing its success, and reducing the reliance on intravenous rehydration. We hypothesize that the strict adherence to EMS use in low-risk children may actually be counterproductive by resulting in reduced fluid intake and potentially increasing the use of intravenous rehydration.

Eligibility Criteria:
Inclusion Criteria:

* ≥3 episodes of vomiting or diarrhea in preceding 24 hours
* Duration of illness less than 96 hours
* Age 6 - 60 months
* Clinical suspicion of acute intestinal infectious process
* Weight ≥ 8 kg
* Clinical dehydration score \< 5
* Capillary refill \< 2 seconds
* Absence of bulging fontanelle
* Absence of bilious vomiting
* Absence of blood in diarrhea/emesis
* Absence of abdominal pain (if present reported as periumbilical in location)
* Absence of abdominal distention
* Absence of acute disease currently requiring treatment
* Absence of co-existing diseases (prematurity, cardiac, renal, neurological, metabolic, endocrine, immunodeficiency, trauma or history of ingestion)

Exclusion Criteria:

* Known gastrointestinal diseases (ie. inflammatory bowel disease, celiac) or any other underlying disease process that might place the child at an increased risk of treatment failure.
* Age \< 6 months
* Weight \< 8 kg
* If premature, corrected gestational age \< 30 weeks
* Presence of hematochezia
* Responsible physician judges the child requires immediate intravenous rehydration
* English language is so limited that consent and/or follow-up is not possible.
* Non-Ontario resident \[Canadian Institute for Health Information (CIHI) follow-up data will not be available\]
Investigation of the Postprandial Response of Two Different PDO Cheeses on Metabolic Biomarkers

The purpose of this study was the investigation of the postprandial metabolic responses, after the intake of a traditional, Ladotyri Mytilinis cheese, compared to corresponding responses after an Italian Parmesan cheese consumption, in healthy participants.

A pilot cross-over, randomized and single-blinded, intervention-clinical trial was conducted, in ten healthy men and women subjects, aged eighteen to thirty years, after random allocation into the control and the intervention group, received a high-fat and carbohydrates meal, containing Ladotyri Mytilinis (the authentic nonrefrigerated recipe) or Italian Parmesan, PDO cheeses. After a washout week, participants consumed the same meals, conversely. Differences on postprandial responses of serum total, High Density Lipoprotein (HDL-), Low Density Lipoprotein (LDL-) cholesterol, glucose, triglycerides and uric acid levels, as well as of plasma total antioxidant capacity according to Ferric Reducing Antioxidant Power method, were determined between groups in fasting, thirty minutes, one and a half hour, and three hours after meal intake.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-65 years
* Willingness to join and complete the nutritional intervention

Exclusion Criteria:

* Inability or unwillingness to provide informed consent
* Three-month nutritional supplement
* Age over 65 years or below 18 years
* Chronic diseases history
* Hemoglobin A1c - HbA1c \> 5.7 %
* Abnormal Body Mass Index (BMI) (\> 25 kg / m2)
* Abnormal hematological or biochemical profile (total cholesterol \> 240 mg/dL, triglycerides \> 250 mg/dL, glucose \> 100 mg/dL)
* Alcohol overdose (\> 40 g alcohol / day)
* Heavy smoking (\> 10 cigarettes / day)
* Concurrent participation in another intervention study or unconsciousness in previous blood draws
Minnesota Inclusive LTSS for LGBTQ Seniors

This study is designed to help improve the care of sexual and gender minority (SGM) with Alzheimer's Disease and Alzheimer's Disease Related Dementia (AD/ADRD) in long-term services and supports (LTSS) by training the state's LTSS workforce in SGM culturally responsive care. The randomized controlled trial will rigorously test the effects of an in person versus an online training program on improving SGM culturally responsive care with a waitlist control.

The study involves conducting a 3-arm, stratified (management/staff), group (agency) randomized controlled trial (RCT) of the in-person vs. online intervention vs. waitlist control on organizational factors (i.e., environment and policy) and on staff knowledge, attitudes, and skills.

Eligibility Criteria:
Inclusion Criteria:

* licensure in Minnesota to provide nursing and/or as a housing with services establishment
* Willingness to undertake a policy and environment review at baseline and 6 months later
* having at least 5 managers/ supervisors and 5 staff.

Exclusion Criteria:

* Participants who cannot speak and read English