cyrilzakka/clinical-trials huggingface dataset:
Intravenous Pantoloc In Aspirin-Induced Ulcer Bleeding

The aim of the study is to investigate whether intravenous infusion of pantoprazole (Pantoloc) is effective in preventing recurrent bleeding in patients who present with acute ulcer bleeding and continue to use aspirin

Aspirin is an effective treatment for acute stroke and heart attack. However, aspirin also induces ulcer and provokes acute ulcer bleeding. Thus, aspirin is often withheld in acute ulcer bleeding but this precipitate recurrent stroke or heart attack. We previously showed that intravenous infusion of a potent acid suppressant substantially reduced the incidence of recurrent ulcer bleeding in patients who withheld aspirin. The aim of this study is to investigate whether intravenous infusion of an acid suppressant (Pantoprazole) is effective in preventing recurrent ulcer bleeding with continuous use of aspirin.

Eligibility Criteria:
Inclusion Criteria:

* Patients received daily anti-platelet therapy for vascular prophylaxis before admission and will continue need to do so
* Patinets with bleeding peptic ulcers;ulcer actively bleeding or with SRH (Forrest I, IIa and IIb ulcers)
* Endoscopic haemostasis achieved

Exclusion Criteria:

* Presence of ulcer complication precluding endoscopic treatment such as gastric outlet obstruction or ulcer perforation mandating surgical intervention.
* Concomitant use of anticoagulant, NSAIDs or steroid
* Pending to undergo cardiac interventions that need double anti-platelet agent
* Pregnancy
* Terminal illness, or cancer
Errors of Refraction Among Primary School Children

This study will include primary school children to evalute their refraction and follow those who will wear glasses to detect their compliance.

Visual acuity will be measured using autorefractometer after cycloplegic eye drops 3 times and glasses will be prescribed for those who are needed. Follow up of the students to detect their compliance of wearing correction.


Eligibility Criteria:
Inclusion Criteria:

* Primary school student less than 12 years.
* No sensory defect in those children.

Exclusion Criteria:

* Corneal opacity.
* Abnormal fundus lesion.
Accuracy of Visual Range of Motion Estimates

Examine the accuracy of visual estimates of various joint angles by physical therapists at various levels of education and clinical practice, taking into account years of experience, areas of practices and specialty certifications.

Physical therapists oftentimes will estimate rather than measure joint range of motion. The accuracy of visual estimates of various joint measurements has not been previously assessed. No comparison has been done for years of experience and accuracy of estimations. This study will create a survey with pictures of joints at previously measured angles and therapists and students will be asked to estimate the range of motion. Various statistical analyses will be performed to determine accuracy and comparisons.

Eligibility Criteria:
Inclusion Criteria:

* licensed physical therapists
* students currently enrolled in an accredited doctorate of physical therapy program

Exclusion Criteria:

* students have not been trained in range of motion measurements
* are not licensed physical therapists
Companion Pharmacogenetic Study to UMCC 9900/9901

The purpose is to examine the original breast tumor material to see how much of a metabolizing enzyme (CYP3A4) is present in tumor material. The researchers want to see if this is in any way associated with how the patient responded to docetaxel. They also want to examine the genes in the tumor that are responsible for the production of CYP metabolizing enzymes, to see if they are normal or if they have polymorphisms, or change compared to 'normal' CYP metabolizing enzymes.


Eligibility Criteria:
Inclusion Criteria:

* Patients who participated on UMCC 9900/9901
* Living patients must give written informed consent

Exclusion Criteria:

* No tumor block tissue available
Defining 'Normal' Liver Function Tests & FibroScan Values in Pregnancy

The main aim of this single-site prospective study is to use serum liver function tests and FibroScan as assessment tools to measure liver disease in pregnant women with or without liver disease at King's College Hospital. This will be assessed during each trimester of pregnancy. FibroScan will assess liver stiffness in these participants and will be used as a surrogate marker for fibrosis.

Approximately 500 pregnant participants above the age of 16 years will be enrolled into this study, which will occur over an 18-month period (February 2019 to August 2020).

In this prospective cohort study, pregnant participants with or without liver disease will be identified through clinics at King's College Hospital. Participants attending the antenatal, specialist liver-pregnancy clinic and general liver clinics will be given an information leaflet detailing the study. Participants can be interviewed in a clinic room to answer any queries. The participant is then given the option of consenting and participating in the study during that clinic consultation or to contact us at a future date should they need further time for consideration.

Baseline participant details will be collected as well as any preceding liver diagnosis and other comorbidities.

Once consented, the assessment visits will be as follows.

1. Trimester 1 visit (at week 12 booking ultrasound scan):

   - Additional FibroScan after booking scan (ideally 3 hours \*fasting will be required before this scan)
2. Trimester 2 visit (at week 20 routine ultrasound scan):

   * Additional FibroScan after ultrasound scan (ideally 3 hours \*fasting will be required before this scan)
   * Blood tests to be taken at this point
3. Trimester 3 visit (if occurs, e.g. in participants with diabetes):

   * FibroScan (ideally 3 hours \*fasting will be required before this scan)
   * Blood tests (liver function tests)
4. Post-partum visit (if occurs):

   * FibroScan (ideally 3 hours \*fasting will be required before this scan)
   * Blood tests (liver function tests)

     * Fasting = nothing to eat or drink (except water)

The participants will be followed up during pregnancy and, if required, for 3 months after pregnancy, as per routine Obstetric care. Delivery, maternal and foetal outcomes will also be documented. This information will come from the participant online medical records.

Eligibility Criteria:
Inclusion Criteria:

* Must be female
* Must be aged 16 years and above and be of childbearing age
* Must be participants attending clinic at King's College Hospital
* Must be in the 1st and 2nd trimester of a pregnancy
* Must be willing and able to provide written informed consent

Exclusion Criteria:

* Non-viable pregnancy
* Pacemaker in situ
* Concurrent and/or recent involvement in other research that is likely to interfere with FibroScan results within last 3 months of study enrolment
Comparison of Glottic Views and Intubation Times in the Supine and 25 Degree Back-up Positions

Our hypothesis is that the view of the glottis may be improved by putting all patients requiring intubation in the ramped or back up position while maintaining the classic sniffing position.

The sniffing position has traditionally been considered the optimal head position for direct laryngoscopy and is the usual patient position preferred by most anaesthetists. In theory, neck flexion aligns the pharyngeal and laryngeal axes, and head extension at the atlanto-occipital joint aligns the oral axis with these two axes allowing the line of sight to fall on the glottis. It is recognized as the starting head position for direct laryngoscopy because it provides the best chance of adequate exposure.

However the sniffing position does not guarantee adequate exposure in all patients because many other anatomical factors control the final degree of visualization.

To achieve a proper sniffing position in obese patients, the "ramped" (or the back-up) position has been used as this produces better neck flexion and head extension in these patients when compared to the horizontal supine position. Also the forces required to elevate and move the tongue and other tissues out of the line of sight are less when the patients are ramped.

Our hypothesis is that the view of the glottis may be improved by putting all (ie not only obese) patients requiring intubation in the ramped or back up position while maintaining the classic sniffing position.

Eligibility Criteria:
Inclusion Criteria:

* Adult surgical patients who required intubation as part of their routine anaesthesia

Exclusion Criteria:

1. Patients less than 18 years old,
2. Patients recognised to have difficult airways where an alternative method of intubation (e.g. fibre optic) was the method of choice,
3. Patients undergoing emergency surgery where patient positioning and data collection might cause delay (e.g. exsanguinating patients) or where the supine position is not optimal (e.g. brisk bleeding into the upper airway),
4. Patients requiring rapid sequence induction of anaesthesia
Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block

The primary objective of this study is to propose new treatment algorithm (strategy) for patients with Acute Coronary Syndrome (ACS) and left bundle-branch block (LBBB).

Current recommendations on the treatment of acute coronary syndrome (ACS) dictate urgent reperfusion therapy in the case of evolving myocardial infarction with ST-segment elevation (STEMI). Optimal use of PCI (preferably) or thrombolysis in this situation requires a rapid and correct diagnosis.

According to the ESC'2008 and ACC/AHA'2009 focused update guidelines patients admitted to the hospital within 12 hours after the onset of chest pain with new (or presumably new) left bundle-branch block (LBBB) should be treated like patients having STEMI (class I, level A). However, it is well-known that in patients with concomitant LBBB, the ECG manifestations of acute myocardial injury may be masked.

ACS may occur in a patient with "true old" LBBB (when doctor has/has not an ability to compare the new ECG with the previous one) or (presumably) new LBBB.

There is a high risk of non receiving appropriate therapy or of receiving inappropriate therapy (thrombolysis instead of LMWH/UFH/fondaparinux).

Eligibility Criteria:
Inclusion Criteria:

* Age 18 - 75 years
* Ischemic discomfort (ie, ischemic chest pain or equivalent) at rest ≥20 minutes within previous 24 hours.
* Any (new, presumably new, or old) LBBB on the prehospital (ambulance) or admission ECG.
* Urgent coronary angiography (followed, when indicated, by PCI), ideally within 90 minutes after admission

Exclusion Criteria:

* all-comers design
Assessment of Patient Positioning

The purpose of this study is to ultimately prevent injuries to nerves during surgical procedures. Living donor liver transplant or hepatectomy (removal of a piece of the liver) patients will receive an arterial line as standard of care. The arterial line helps monitor blood pressure along with the compression of important vessels during surgery. In addition, research participants will undergo neuromuscular monitoring using Somato-Sensory Evoked Potential (SSEP) or Evoked Potential Assessment Device (EPAD). During an operation, neuromuscular monitoring can tell doctors if the nerves being studied are working normally or if they are at risk for injury. This study will help investigators to understand what kind of monitoring is best to prevent nerve injuries during a surgical procedure.

As standard of care, research participants undergoing a living donor liver transplant or other liver surgeries will receive a right-sided radial arterial line to monitor his/her blood pressure along with the compression of important vessels during surgery. These measurements will be captured throughout the surgical procedure. If blunting of the arterial line wave form occurs, the anesthesiology team alerts the surgical team to release the retractors until the wave form returns to baseline. Depression of the radial arterial line wave form will be captured, time-stamped, and stored by the research transplant anesthesiology team.

Additionally as part of research, participants will receive neuromuscular monitoring using SSEP or EPAD to measure their nerve signals during the surgery (3-6 hours). SSEP or EPAD measurements will occur at the median and ulnar nerve and will be captured throughout the surgical procedure. The research neuromonitoring team will consists of highly skilled technicians, who monitor patients during neurosurgical and orthopedic surgeries. SSEP or EPAD output captured during the surgery will be time-stamped, stored, and interpreted by a Neurologist. To investigate if a correlation exists, SSEP or EPAD abnormalities will be correlated and analyzed with the arterial wave form depressions.

To determine whether a correlation exists with clinical outcomes, a prospective medical record review will be conducted. Before performing the prospective medical record review, authorized research personnel will obtain informed consent from each participant.

Eligibility Criteria:
Inclusion Criteria:

* All adult living liver donors and liver surgery patients at Northwestern Memorial Hospital (surgical setup is similar for living liver donor surgery and liver surgery (e.g. retractors, arterial line for monitoring, surgeons). Investigators will approach both living liver donors and liver surgery patients for enrollment to receive additional neuromuscular monitoring.
* All subjects must have given signed, informed consent prior to registration on the study.

Exclusion Criteria:

* Anyone not meeting the inclusion criteria.
Investigation of the Accuracy of a Low-cost, Portable, Autorefractor to Provide Well-tolerated Eyeglass Prescriptions

At the Aravind Eye Hospital (AEH) in Madurai, India, patients ages 18-40 receiving treatment for refractive error who choose to enroll in the study will be evaluated using subjective refraction and objective refraction, by way of the QuickSee autorefractor. Patients will then be randomized into one of two treatment plans: receive glasses from objective measure first then subjective measure second, and vice versa. After one week of wearing the first pair of glasses, patient preferences are assessed, and glasses are switched. After a week of wearing the second pair of glasses from the alternate measurement method, patient preferences are again assessed. Patients may then decide which pair patient like best. This is a double blind, case-crossover clinical trial.


Eligibility Criteria:
Inclusion Criteria: Participants-

1. who visit a Vision Center for their eye check-up
2. who are aged between 18 years and 40 years

Exclusion Criteria: Participants-

1. whose refractive error is not within the detection range of the QuickSee device: -10 to +10 D
2. who have a cylindrical power greater than 3 D
3. who have to travel long distances (beyond 10kms) to the hospital
4. who choose to buy spectacles that are priced more than Rs. 2000/- per pair
5. who have speech or hearing impairment
6. who do not speak the local language, Tamil
7. who do not want to purchase spectacles from AEH
Early Vascular Ageing in the YOUth

This is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on Intima-Media-Thickness of the carotid artery and the aorta and on the Pulse-Wave Velocity.

A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

EVA4YOU is a cross-sectional study enrolling 3000 students and apprentices aged between 14 and 19 years. Examinations are conducted at schools and companies throughout Tyrol, Austria and include laboratory measurements; standardized medical interviews; anthropometry; liver elastography; ultrasonography of the carotid artery and the aorta, and blood pressure, bioelectrical impedance; visceral abdominal fat-tissue-thickness measurement, pulse-wave velocity measurements.

The study hypothesis is that the cardiovascular risk factors measured already influence the formation of atherosclerosis (measured as carotid and aortic Intima-Media Thickness and Pulse-Wave-Velocity) in adolescents.

A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

Eligibility Criteria:
Inclusion Criteria:

* Adolescents at the age of 14 to 19 years
* Signed informed consent of subjects (and legal guardian if subject \< 18 years of age)

Exclusion Criteria:

* Persons, who are suspended upon a court order or upon other legal processes or are accommodated according to the Hospitalization Act, or for whom a custodian is appointed (or appointment is initiated).
* Persons with impaired power of judgment
* Persons who are currently engaged in military or community service
Internet-Delivered CBT for Children With Functional Abdominal Pain Disorders

This randomized controlled study aims to evaluate the efficacy of exposure-based Internet-delivered cognitive behavior therapy for children 8-12 years with Functional Abdominal Pain Disorders. The children participate along with their parents, who will also receive specific modules with information on how to support their children in the treatment. Predictors and mediators for treatment effects will be studied as well as the cost effectiveness of the intervention.


Eligibility Criteria:
Inclusion Criteria:

* Children 8-12 years with either irritable bowel syndrome, functional dyspepsia or functional abdominal pain - not otherwise specified diagnosed according to Rome-III or Rome-IV criteria.
* Psychopharmacological medication stable for at least a month if medicating.
* Child and at least one parent speaking and writing swedish.
* Access to computer with Internet connection.

Exclusion Criteria:

* Severe somatic disorder and/or if the child fulfills criteria of other disorder that better explains the abdominal symptoms.
* Severe psychiatric or social problems that needs other care.
* Ongoing psychological treatment.
* School absenteeism more than 40 %.
Antiseptic Scrub Contamination and Transmission Trial

This study is a prospective, blinded, randomized, controlled trial (RCT) with a crossover design to determine if antiseptic-impregnated surgical scrubs decrease the burden of healthcare providers (HCP) clothing contamination compared to standard, control surgical scrubs following a 12-hour ICU shift.

The investigators will perform a 3-arm prospective, blinded, randomized, controlled trial with a cross-over design to determine if HCP who wear antiseptic-impregnated clothing (i.e., surgical scrubs) will acquire and transmit fewer pathogens than HCP wearing standard clothing.

A total of 40 intensive care unit (ICU) nurses (from the Medical and Surgical ICUs in the Duke Medical Pavilion) will be enrolled and sign a consent form to participate in the study. Their main task will be to wear control (non- antiseptic) scrubs (Arm 1) and two different types of antiseptic-impregnated scrubs (Arms 2 and 3). Subjects will be randomized to one of 6 strategies. Each nurse typically cares for two patients each day and will be enrolled for three consecutive days (or shifts, if they do not work for 3 days in a row). Once the nurses have consented to participate in this project, the study coordinator will provide the 3 sets of scrubs and will label them with numbers, thus blinding the nurses to which scrubs they will wear on which day. The nurse will wear the scrubs on the 3 pre-arranged shifts.

Data will be summarized using standard statistical methods. The investigators will utilize linear mixed models to compare relative differences in the amount of contamination between arms at the end of the shift to adjust for our crossover study design. Mixed effects logistic regression models will be used to compare proportions. All calculations will be adjusted for the amount of environmental contamination observed during the shift and contamination on HCP clothing in the beginning of the shift. Statistical significance for two primary comparisons (each antiseptic scrub versus control) will be corrected for multiple comparisons.

This is a minimal risk study and the investigators have no safety concerns from the patients or nurses as relates to obtaining swabs and room cultures, nor with wearing the scrubs and having them cultured. Data will be stored on encrypted Duke Medicine servers (participant log \& study IDs) and/or in our REDCap database (all other data collected for the study).

Eligibility Criteria:
Inclusion Criteria:

* All intensive care unit (ICU) nurses at Duke Medical Center are eligible to participate in this study.

Exclusion Criteria:

* Nurses outside the Duke Medical Center ICU will not be eligible to participate in this study.
Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients

The propose of this study is to compare two methods of physical treatment for benign paroxysmal positional vertigo, by evaluating treatment effects on postural stability.

The trail design is a double blinded randomized controlled trail, with each patient going through three evaluations: before treatment, 1 week after treatment and 60 days after treatment.


Eligibility Criteria:
Inclusion Criteria:

* medical referral for treating "vertigo"
* subject has short episodes of rotatory vertigo (up to 1 minute)
* subject has positive Hallpike-Dix test with typical nystagmus
* repeated Hallpike-dix test will show fatigability

Exclusion Criteria:

* Hallpike-Dix test produces vertigo without nystagmus
* subject has BPPV of the horizontal or anterior semi-circular canal
* subject has other known vestibular or neurologic condition
* subject has nystagmus of a different type
* subject has a cervical spine problem which prevents the utilization of Epley or Semont maneuvers
* subject is unable to stand for 1 minute
* subject gets pharmacologic treatment for vertigo while doing the postural stability evaluation
* subject is under 18 years old or a pregnant female or cannot obtain informed concent
Mesalamine Pellet Formulation to Maintain Remission of Mild to Moderate Ulcerative Colitis

The purpose of this study is to compare the maintenance of mild to moderate ulcerative colitis remission with six months of treatment with 1.5 grams of mesalamine pellets each day versus placebo.

This is a phase 3, multicenter, double-blind, randomized, placebo controlled study evaluating the effectiveness and safety of eMG 1.5 g given once daily (QD) compared with placebo in approximately 300 subjects with demonstrated remission from UC. Eligible subjects are randomized in a 2:1 ratio (active:placebo) to receive 1 of 2 treatments: 1.5g eMG QD (four capsules total) or matching placebo capsules QD for 6 months.

The study consists of a Screening phase (completed within 7 days prior to randomization), a Treatment phase (6 months), and a Follow-up visit (2 weeks after end-of-study \[EOS\] visit). The Treatment phase consists of 4 scheduled study visits: Visit 1 (Baseline)/Randomization (Day 1), Visit 2 (Month 1), Visit 3 (Month 3), Visit 4/EOS (Month 6).

Primary objective:

To compare the maintenance of remission from mild to moderate ulcerative colitis (UC) as measured by rectal bleeding and endoscopic mucosal appearance after 6 months of treatment with encapsulated mesalamine granules (eMG) at 1.5 g QD, as compared with placebo.

Secondary objective:

To compare the safety and tolerability of long-term dosing with eMG at 1.5 g QD as compared with placebo in the maintenance of remission from mild to moderate UC.

Eligibility Criteria:
Inclusion Criteria:

* Confirmed diagnosis of ulcerative colitis and in remission for at least 1 month.
* Greater than 18 years of age.

Exclusion Criteria:

* Allergy/intolerance to aspirin, mesalamine or other salicylates.
* Prior bowel surgery other than appendectomy.
* Pregnancy, at risk of pregnancy or lactating.
* HIV or hepatitis B or C.