cyrilzakka/clinical-trials huggingface dataset:
The Incidence of Perioperative Deep Venous Thromboses of the Lower Extremities

The study's hypothesis is that there are some patients who come for surgery who have asymptomatic clots in their lower extremities upon their arrival to the hospital for their surgical admission. We will be performing duplex studies of the subjects' legs before their surgery to determine how often clots are present. We will also perform duplex scans of the legs after the subjects' surgeries to determine what factors (surgical, anesthetic, co-morbidities)are correlated with the development of DVTs.


Eligibility Criteria:
Inclusion Criteria:

* Age 18+ and consentable

Exclusion Criteria:

* Anticoagulation therapy or known DVT
Influence of Core Muscles Activation Using Physical Fitness on the Performance of Chest Compression

Chest compression, a key component of cardiopulmonary resuscitation (CPR), has a major role for survival of cardiac arrest patients. According to 2015 American heart association (AHA) guideline, rescuers provide high quality CPR to adult cardiac arrest patients including 5 to 6 cm depth and 100 to 120 beat per minute rate chest compression.

However, in CPR situation, chest compression depth and rate vary according to provider's muscle strength. In other words, the individual difference of the degree of physical activity will make the different result for CPR. So, the investigators hypothesize that the core muscles activation using physical fitness improves the quality of chest compression and the quality of CPR, eventually.


Eligibility Criteria:
Inclusion Criteria:

* medical school students and interns had experienced in cardiopulmonary resuscitation (CPR) education

Exclusion Criteria:

* patients with musculoskeletal disease
* patients with cardiovascular disease
* patients with lung disease
Pre-emptive Analgesic Administration in Primary Tooth Extraction

Brief Summary:

Aims: The objective of the current study will be to compare the effectiveness of Ibuprofen, Acetaminophen, and Placebo on reducing injection pain and post-operative pain in primary tooth extraction, and to compare the parents' satisfaction.

Design: This will be a blinded, randomized placebo-controlled trial including sixty six cooperative children, aged 6-8 years old.

Background and Aims: The pain could be a problem for the patients during the first few hours after the extraction because of both soft and hard tissues trauma during the operation, despite that the local anesthesia will last for a long time in most of the cases.

There are no enough studies that ensure the validity of giving any analgesic in reducing injection pain and post-operative pain in primary tooth extraction so far.

Design: This will be a blinded, randomized placebo-controlled trial including sixty six cooperative children, aged 6-8 years old, randomly assigned to one of three groups to receive one of the oral suspension drugs, that have the same colour and taste, via pre-calibrated medication bottles, which are identical, numbered and containing the same amount of pre-calibrated dosages, as per the following portions:

1. Acetaminophen syrup: 160mg/5ml
2. Placebo solution
3. Ibuprofen suspension: 100mg/5ml

Eligibility Criteria:
Inclusion Criteria:

1. Teeth with an abscess or infection exceeding one-third of the interradicular area (not exceeding the oral cavity) 2. Unrestorable decayed teeth. 3. Teeth with periapical / interradicular lesions.

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Exclusion Criteria:

Teeth with advanced root resorption (a third of the root at least)
Modeling TMS-induced Cortical Network Activity

This is a study of normal brain physiology in healthy human volunteers. The study aims to understand the physiology of connectivity between brain regions. To reach this aim, it delivers single-pulse transcranial magnetic stimulation (spTMS) to one or two brain areas at a time while electroencephalography (EEG) is measured. When only one brain area is stimulated (uni-focal TMS), the goal is to record how many milliseconds it takes for the activity to spread from the stimulated area to other brain regions (conduction delay). When two brain areas are stimulated (bi-focal TMS), the TMS pulses are separated by a short millisecond-level time interval ("asynchrony") in a so-called paired associative stimulation (PAS) design. The central hypothesis is that PAS may increase or decrease connectivity between the stimulated areas depending on the asynchrony value. All techniques in the study are non-invasive and considered safe.

The goal of the study is to illuminate the physiology of inter-regional connectivity in the human brain. Participants are healthy adult volunteers without disorders or medications influencing brain function (N=80). During uni-focal TMS, only one brain area is stimulated at a time, and the conduction delays and connectivity strengths between the stimulated brain area and other brain regions are quantified with source-resolved EEG. During the bi-focal TMS sessions, a range of negative and positive PAS asynchronies (from minus 50 to + 50 ms relative to the conduction delays) will be tested in separate sessions, and the within-session connectivity changes from PAS are estimated by applying uni-focal TMS before and after PAS. The targeted brain areas include the primary motor cortices in the left and right hemisphere as well as areas outside the primary motor cortices. All techniques included in the study are non-invasive and considered safe: TMS, EEG, electromyography (EMG), magnetic resonance imaging (MRI), diffusion MRI (dMRI), functional MRI (fMRI), and behavioral measures. The TMS parameters in this study are considered safe, as only single or pairs of TMS pulses are delivered.

Eligibility Criteria:
Inclusion Criteria:

* Healthy
* Normal hearing and (corrected) vision
* Able to understand and give informed consent

Exclusion Criteria:

* Metal in the body (rods, plates, screws, shrapnel, dentures, IUD)
* Metallic particles in the eye
* Surgical clips in the head or previous neurosurgery
* Cardiac pacemaker or pacemaker wires
* Neurostimulators
* Implanted pumps
* Any magnetic particles in the body
* Cochlear implants
* Prosthetic heart valves
* Epilepsy or any other type of seizure history
* Significant claustrophobia
* Meniere's disease
* Pregnancy or breast-feeding
* Diagnoses or medications (neurological or psychiatric) influencing brain function
* History of, or current, substance abuse
* History of developmental disorders (e.g., dyslexia)
* Failure to perform the behavioral tasks
* Prisoners
Computed Tomography (CT) in Head and Neck Patients

This study is conducting a comparison of chest x-ray (CXR) and minimum dose thoracic CT (MnDCT) in the detection of lung nodules (metastases) in patients with head and neck carcinoma.

A comparison of chest x-ray (CXR) and minimum dose thoracic CT (MnDCT)in the detection of lung nodules (metastases) in patients with head and neck carcinoma

Eligibility Criteria:
Inclusion Criteria:

* Patients with squamous cell carcinoma of the head and neck

Exclusion Criteria:

* None
Diagnostic Performance of Deep Learning for Angle Closure

Primary angle closure diseases (PACD) are commonly seen in Asia. In clinical practice, gonioscopy is the gold standard for angle width classification in PACD patietns. However, gonioscopy is a contact examination and needs a long learning curve. Anterior segment optical coherence tomography (AS-OCT) is a non-contact test which can obtain three dimensional images of the anterior segment within seconds. Therefore, the investigators designed the study to verify if AS-OCT based deep learning algorithm is able to detect the PACD subjects diagnosed by gonioscopy.


Eligibility Criteria:
The inclusion criteria in the study were as follows: (1) All participants must be ≥ 18 years old; (2) Study subjects had a previous diagnosis of the ACA status (narrow or open, PAS or non-PAS) based on gonioscopy, SS-OCT scans and medical history records. Exclusion criteria of the data include: (1) poor compliance in receiving gonioscopy examination; (2) unclear AS-OCT scans due to blinking or out of focus; (3) recent use of miotics within a month; 4) secondary angle closure sue to subluxation or dislocation, uveitis, neovascular glaucoma, et al.; 5) history of ocular surgery or laser iridotomy; 6) patients who previously had an episode of primary angle closure (which was obtained on history by asking the patients).
Pharmacokinetics of Oral Desipramine With and Without Concomitant Administration of Crobenetine Infusion in Healthy Male Subjects

To assess the steady state pharmacokinetics of Desipramine with/without concomitant administration of Crobenetine.


Eligibility Criteria:
Inclusion Criteria:

All participants in the study should be healthy males, range from 21 to 50 years of age and their bodymass index (BMI) be within 18.5 to 29.9 kg/m2.

In accordance with Good Clinical Practice and local legislation all volunteers will have given their written informed consent prior to admission to the study.

Exclusion Criteria:

* Any finding of the medical examination (including blood pressure, pulse rate and ECG) deviating from normal and of clinical relevance
* Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders
* Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders
* History of relevant orthostatic hypotension, fainting spells or blackouts
* Chronic or relevant acute infections
* History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator
* Intake of drugs with a long half-life (\> 24 hours) within at least one month or less than ten half-lives of the respective drug before enrolment in the study
* Use of any drugs which might influence the results of the trial (within one week prior to administration or during the trial)
* Participation in another trial with an investigational drug (within two months prior to administration or during the trial)
* Smoker (\> 10 cigarettes or \> 3 cigars or \> 3 pipes/day)
* Inability to refrain from smoking on trial days
* Alcohol abuse (\> 60 g/day)
* Drug abuse
* Blood donation (\>= 100 mL within four weeks prior to administration or during the trial)
* Excessive physical activities (within the last week before the study)
* Any laboratory value outside the reference range of clinical relevance
* Cytochrome P450 2D6 poor metaboliser (to be determined by phenotyping or genotyping)
Nature as a Buffer Among People With Chronic Pain

This randomized controlled trial examines the effect of nature exposure on pain intensity levels among older adults who experience chronic pain. Investigators examine the effects of nature on: the experience of chronic pain, on pain catastrophizing, and on attention restoration.

Nature has been used to reduce pain in the context of acute pain (e.g., during painful medical procedures) but nature has not been examined as an intervention strategy to address chronic pain. Second, the mechanism though which nature might reduce the experience of pain is not well understood. Participants are cognitively intact individuals aged 60-90 who experience chronic pain and who rate their health as fair, good or excellent. Participants are randomly assigned to one of three conditions: virtual reality (VR) nature; VR built environment; or control. Researchers examine effects of VR nature exposure on the experience of chronic pain, pain catastrophizing, and on attention restoration as well as the relations among these variables.

Eligibility Criteria:
Inclusion Criteria:

* rate health as "fair" "good" or "excellent"
* experience chronic pain
* cognitively intact
* do not use wheelchair

Exclusion Criteria:
Cardioprotection by Sevoflurane Preconditioning in Noncardiac Thoracic Surgery

It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties. This has been shown in animal studies and in patients that underwent cardiac surgery. The aim of our study is to examine if Sevoflurane, a volatile anaesthetic, has this properties in patients undergoing lung surgery.


Eligibility Criteria:
Inclusion Criteria:

* Lung surgery
* ASA (American Society of Anesthesiologists) physical status 1-3

Exclusion Criteria:

* Disposition for malignant hyperthermia
* Medication with ß-blocking drugs
* Use of clonidin
Scleroderma Registry & Repository At the Hospital for Special Surgery

The overall objective of the Scleroderma Registry is to support and promote the basic science and clinical research of this complex rheumatic disease at the Hospital for Special Surgery (HSS). The registry facilitates our understanding of the clinical features, pathobiology, genetics of Scleroderma. This will ultimately lead to a potential treatment for this currently untreatable condition.

What will be asked of you:

* Completion of 2 health questionnaires
* Donation of research bloods. This is optional, but encouraged (if possible).
* We also encourage patients who come for initial visits to return so follow-up data can be collected.

Benefits to Patients:

* The HSS Scleroderma Registry gives patients the opportunity to participate in observational research with the goal of improving the lives of patients in the future.
* By donating research bloods and providing clinical information, patients will help generate new knowledge about Scleroderma that can guide the treatment and care of patients afflicted with this rare disease.
* Patients will also receive a comprehensive, medical evaluation from an HSS physician who specializes in treating Scleroderma. He or she will provide guidance on treatment options and recommendations for current or upcoming clinical trials.
* Physicians will also make patients aware of the resources available to them, including support groups and educational programs.

Eligibility Criteria:
Inclusion Criteria:

* Individuals older than 18 years of age with Scleroderma

Exclusion Criteria:

* Individuals younger than 18 years of age
* Individuals older than 18 years of age without Scleroderma
Acute Pediatric Fracture Analgesia Study

A clinical trial comparing ibuprofen and acetaminophen with codeine for children after discharge from the emergency department. We hypothesize that Ibuprofen will provide 20% more effective analgesia compared to acetaminophen with codeine in children with uncomplicated forearm fractures.

A clinical trial comparing ibuprofen and acetaminophen with codeine for children after discharge from the emergency department. We hypothesize that Ibuprofen will provide 20% more effective analgesia compared to acetaminophen with codeine in children with uncomplicated forearm fractures. A random table will be used to generate an assignment of the participants to either ibuprofen or acetaminophen with codeine. Assessment of the child's pain severity, pain medication use, functional limitations and parental satisfaction will allow for identification of a difference in the management of pain in the first 72 hours after a forearm fracture. Descriptive statistics will be used to analyze demographic data.

Eligibility Criteria:
Inclusion Criteria:

* Children ages 4-18 years of age with an uncomplicated forearm fracture that is evaluated within 12 hours of injury and requires only splinting

Exclusion Criteria:

* A history of a bleeding disorder, uncontrolled chronic medical disease, regularly use of or allergy to acetaminophen, ibuprofen, or codeine or developmental delay
A Two-Part Phase 1 Study to Investigate the Safety and Tolerability of Supratherapeutic Dose of Zanubrutinib and Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects

A Two-Part Phase 1 Study to Investigate A) Safety and Tolerability of Supratherapeutic dose of Zanubrutinib (BGB-3111) and B) Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects

This is a Two-Part Phase 1 Study.

Part A: This is a randomized, placebo-controlled, double blind, single dose study to evaluate the safety and tolerability of a single oral supratherapeutic dose of zanubrutinib in eight (8) subjects.

Part B: This is a randomized, placebo and positive-controlled, double-blind, 4-way crossover study being conducted in about 28 subjects to investigate the effect of a single therapeutic dose of zanubrutinib, a supratherapeutic dose of zanubrutinib and placebo on cardiac repolarization. Open-label Moxifloxacin (400 mg), a fluoroquinolone broad spectrum antibiotic will be used as a positive control.

Eligibility Criteria:
Inclusion Criteria: All subjects

1. Body mass index (BMI) 18 - 33 kg/m2, inclusive.
2. In good general health as assessed by the Investigator.
3. Females of non-child bearing potential.
4. Males without a vasectomy will agree to use required barrier contraception, and will agree to not donate sperm from the time of the first dose of BGB-3111 until ≥ 90 days after the last dose of BGB-3111.
5. Able to comprehend and willing to sign consent.

Exclusion Criteria: All subjects

1. Subjects with a clinically relevant history or presence of any clinically significant disease.
2. Personal or known family history of congenital or acquired long QT syndrome or cardiovascular disease.
3. Women of child-bearing potential.
4. History of alcoholism or drug/chemical abuse within 6 months.
An Assistant Model for IRD Care Needs: A Randomized Control Trial

Conduct a multicenter randomized controlled study based on the comprehensive deep learning model for inherited retinal diseases (EyeFM-IRDs). Through our established comprehensive deep learning model for inherited retinal diseases (EyeFM-IRDs model), the following objectives can be achieved: complete the initial screening of IRD patients based on the EyeFM-IRDs model, improve the correct referral of IRD patients to the fundus specialty or genetic eye disease specialty clinic; through consultation and ophthalmic examination, achieve the goal that the EyeFM-IRDs assisted by fundus doctors can improve the diagnosis of IRD compared to fundus doctors alone, effectively screen out negative patients, and avoid unnecessary WES examinations; based on a panel of gene mutation types with treatment methods that we have previously constructed. The EyeFM-IRDs model predicts the specific mutation genes of IRD patients based on consultation and fundus examination. This will improve the standardized diagnosis and treatment of IRD diseases, and also provide clinical support and research guidance for future research on IRDs.


Eligibility Criteria:
Inclusion Criteria:

* Presenting with clinical features suggestive of IRD based on the initial assessment by the physician

Exclusion Criteria:

* Refusal to undergo WES genetic testing.
* Screening for a history of intraocular surgery in both eyes within the past 6 months;
* Subjects with severe systemic diseases, intellectual developmental disorders, psychiatric illnesses, etc.
* Patient data that the investigator deems necessary to exclude.
A Retrospective Study Evaluating the Efficacy and Safety of Micafungin Sodium in the Treatment of Invasive Fungal Infections

The objective of this study is to evaluate the efficacy of intravenous micafungin for the empirical antifungal therapy, pre-emptive antifungal therapy, diagnostic driven antifungal therapy or targeted antifungal therapy patients with invasive fungal infections caused by Candida sp. or Aspergillus sp. (fungemia, respiratory mycosis, gastrointestinal mycosis) in adult patients in China.


Eligibility Criteria:
Inclusion Criteria:

* Patients who received Micafungin as empirical antifungal therapy, pre-emptive antifungal therapy, diagnostic driven antifungal therapy or targeted antifungal therapy
* Patients received Micafungin treatment at least 1 dose

Exclusion Criteria:

* Patients received Micafungin treatment combined with other antifungal drugs at the same time
* Neither efficacy or safety can be evaluated because of missing data, confused record
Study of Cerebral Activation During Different Rehabilitation Tasks of Lower Limb in Virtual Mirror Therapy in Healthy Subjects

The purpose of this study is to investigate the cerebral activation during visual motor simulation in healthy subjects in 3 conditions: observation (OBS), observation and imagination (OBS-IM) and observation and realization (OBS-REAL). The investigators goal is to compare cerebral activation during the three different tasks using EEG and fNIRS.

Mirror therapy is a rehabilitation technique that has been shown to be effective in restoring upper limb motor skills in patients with stroke. However, it comes up against certain constraints of clinical use such as installation difficulties or the obligation of symmetrical bilateral work. These constraints can be limited by the use of so-called 2nd generation virtual mirror therapy technologies. It is therefore likely that these new technologies will improve the feasibility and effectiveness of mirror therapy in rehabilitation.

The brain mechanisms involved in virtual mirror therapy are not yet fully understood. EEG (Electroencephalography) and fNIRS (functional Near Infra Red Spectroscopy) are two functional method that allows to study the cerebral cortex changes during different tasks (like fMRI).

These techniques therefore makes it possible to study brain activation under more ecological conditions than fMRI and are therefore particularly suitable for exploring rehabilitation techniques.

This research aims to study and compare in healthy subjects, using EEG and fNIRS, the brain regions involved in three tasks using a virtual mirror therapy device (IVS4 apparatus ; Dessintey, France) implying lower limb control.

The protocol has 3 conditions :

observation (OBS), observation and imagination (OBS-IM) and observation and realization (OBS-REAL).

The order of the 3 conditions will then be randomized to avoid potential biases linked to the sequence of conditions.

The EEG recording will used the 32 channels ENOBIO apparatus. The fNIRS will used the Brite MKII apparatus

Eligibility Criteria:
Inclusion Criteria:

* Subjects aged 18 to 75 years
* Sufficient command of the French language to understand the instructions
* No known neurological medical history
* With social security coverage
* Right-handed subjects with a laterality test of Edinburgh QL\> 40 (Oldfield 1971)

Exclusion Criteria:

* Minor subjects
* Adults under guardianship
* Adults under guardianship
* Pregnant or breastfeeding women
* Subjects who have objected to participating in the study