cyrilzakka/clinical-trials huggingface dataset:
The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau

The National Malaria Programme in Guinea-Bissau recommends paracetamol for all children treated for malaria. We, the investigators of the Bandim Health Project, want to evaluate whether this treatment has any effect on:

* the well-being of the child;
* the parasite clearance time; and
* the rate of a re-appearance of parasites during 35 days of follow-up.

Children presenting at Bandim Health Centre with malaria will be treated with chloroquine plus paracetamol or chloroquine plus placebo. Blood samples will be obtained daily for the first 4 days and then once a week until day 35.

A Cochrane Review was unable to show a superior antipyretic effect of paracetamol compared with placebo in febrile children. Recent research suggests that the time to parasite clearance in non-severe malaria is longer in children being given paracetamol. As the costs associated with the use of paracetamol is not trivial and the risk of adverse effects is not negligible, we want to evaluate the effects of paracetamol on:

* the well-being of the child;
* the parasite clearance time; and
* the recrudescence rate.

Children presenting at Bandim Health Centre with symptoms of malaria and a malaria film showing mono-infection with P.falciparum will, following consent to participate, randomly be allocated to treatment with chloroquine and paracetamol or with chloroquine and placebo.

Blood samples will be obtained daily for the first 4 days. The children will be visited and a malaria film taken on day 7 and then weekly until day 35. On inclusion and whenever parasitaemia is detected a capillary blood sample will be taken for PCR analyses to be able to distinguish re-infection from recrudescence.

During follow-up children are recommended to present at the health centre in case of persistent fever or any other symptoms. Examination and treatment will be free of charge. Whenever a child has re-infection sulfadoxine/pyrimethamine will be used for re-treatment following the recommendation of the National malaria Programme.

After the inclusion of 80 children a preliminary analysis will be performed. If 50% or more of the children in any of the study arms have reappearing parasitaemia the study will be terminated.

If the parasite clearance time and especially the recrudescence rate is higher for children being given paracetamol the current recommendation from the National Malaria Programme should be reconsidered. If children treated with paracetamol feel better during the acute illness making it more likely for them to have en adequate intake of food and liquid this benefit should be considered in the evaluation of the current recommendations.

Eligibility Criteria:
Inclusion Criteria:

* \< 15 years of age
* Presenting at Bandim Health Centre
* Symptoms suggestive of malaria
* At least 20 P. falciparum parasites per 200 leukocytes
* Live in Bandim (to enable follow-up)

Exclusion Criteria:

* Severely ill children considered to need the services of a hospital by the doctor in charge
* Previous idiosyncratic reactions to chloroquine or paracetamol
The Benefit of Functional Movement Control for Patients With Knee Osteoarthritis

The study purpose is to explore the effect of functional movement control for patients who have stage II or III degenerative knee joint disease and also physical inactive. Half of patients will receive aerobic exercise and functional movement control training in combination, while the other will simply receive aerobic exercise.

Physical inactivity, which is a common phenomenon among patients with degenerative knee joint disease has been proved a predictor of increased symptoms and poor general health. However, changing the lifestyle of people with this disease who is physical inactive is still a problem which has not been solved. Knee pain may act as barrier to engage in physical activity and can influence patient's movement performance.

The different effectiveness between the aerobic exercise and functional movement control training.

Aerobic exercise has been proved could improve knee pain for the patients with degenerative knee joint disease.

The functional movement control training could improve knee alignment during walking and other functional activities to increase patient's movement awareness.

Eligibility Criteria:
Inclusion Criteria:

* Participant who was diagnosed has knee osteoarthritis
* Above 40 years old
* Participant who didn't achieve at least 150 min moderate intensity physical activity level per week

Exclusion Criteria:

* Patients with walking disability
* Cannot complete 8 weeks intervention program
* Received arthroscopy or other surgery before 6 months
Effectiveness of Core Stabilization Exercises With and Without Neural Mobilization Technique in Female Patients With Lumbar Radiculopathy Due to Disc Herniation - an RCT Study

Lumbar disc herniation (LDH) is the most frequent cause of lumbosacral radiculopathy and account for 39% of chronic low back pain cases. In approximately 95% of cases LDH occurs at L4-L5 and L5-S1 levels. Maintaining functional stability of lumbar spine necessitates strengthening of the core muscles that plays a key role in lumbar strengthening, motor control and core stability. Core stability may play a role in passive disc stability, reducing the pressure on disc, relieving nerve impingement and radiating pain. Neural mobilization technique involves manual mobilization or exercise that promotes movement between and around the neural structures.This study is intended to add to the existing literature regarding patients with lumbar radiculopathy due to disc herniation, and to report the effectiveness of core stabilization exercises with and without neural mobilization technique in respective population in reduction of associated symptoms, pain and functional disability, enhancing the quality of life, and restoring a prior functional status and activity potential.

An RCT will be conducted on female patients with radiculopathy due to posterolateral disc herniation at L4-S1 levels, visiting Physiotherapy OPD at DUHS Ojha campus. A sample of 70 patients was calculated using PASS v11 software (Microsoft, Redmond, WA, USA). For estimating sample size, pain scores of motor control group (3.4 ±0.9) and motor control+ NDS group (2.5 ±0.8) after 8th session was used from a study conducted earlier. Patients who fulfill the inclusion criteria will be included in the study through convenience sampling, and will be equally allocated either in Core stabilization exercises group A (Control group: n=35) or Core stabilization exercises with Neural mobilization technique group B (Experimental group: n=35). Treatment will be provided on alternate days 3 times a week for 4 consecutive weeks. Patients will be assessed for pain and functional disability prior to the treatment, then at the end of 2nd week and 4th week through 11 points NPRS and Modified Oswestry Disability Questionnaire (MODQ). Data will be entered and analyzed through IBM SPSS version 24 with p-value \< 0.05 will be considered as statistically significant.

Eligibility Criteria:
Inclusion Criteria:

1. Diagnosed and referred females with lumbar disc herniation.
2. Have a confirmed L4-S1 lumbar disc herniation through an MRI.
3. Postero-lateral Disc herniation of stage I \& II.
4. Age group of 30-50 years.
5. Low back pain radiating to one leg for more than 3 months.
6. Positive SLR test reproducing symptoms between 40°-70°.

Exclusion Criteria:

1. Spondylolisthesis, spondylitis, and spinal canal stenosis.
2. Red flags: spinal tumors, cuada equina syndrome, spinal fractures, osteoporosis, infection.
3. Severe vascular disease like DVT.
4. Pregnancy and Gynecological problems.
5. Psychological disorders affecting subject's ability to follow instructions.
European Venous Registry

The European Venous Registry (EVeR) is an international repository of data on the treatments and outcomes of people with deep venous disease. The registry is designed to evaluate the outcomes of venous interventions over a ten-year period, with the ultimate goal to inform clinical decision making through the delivery of scientific evidence.


Eligibility Criteria:
Inclusion Criteria:

* Patients with an imaging-confirmed new diagnosis of acute or chronic lower limb deep venous disease involving the iliac and/or common femoral veins, with or without extension to the inferior vena cava, or patients with an imaging-confirmed new diagnosis involving the IVC only.
* Consent to enter registry.

Exclusion Criteria:

* Unable to consent to enter into registry.
* Isolated upper limb DVT.
* Central venous thrombosis (e.g. superior vena cava obstruction).
* Isolated deep vein thrombosis below the common femoral vein.
* Isolated superficial venous thrombosis.
* Isolated superficial venous thrombophlebitis.
* Isolated varicose veins.
* Aged \<18 years.
Psychological Treatment for Children Suffering From Post Traumatic Stress Symptoms and Mild Traumatic Brain Injury

The purpose of this study is to determine whether Prolonged Exposure Therapy (PE)is effective in the treatment of post-traumatic stress symptoms in children and adolescents with mild traumatic brain injury (m-TBI) due to motor vehicle accident.

Motor vehicle accidents account for a majority of TBI cases and are a leading cause for Post Traumatic Stress Disorder (PTSD) among children. The vast majority of these cases involve mild TBI (mTBI) with persistent post concussion syndromes. However, the empirical data on treatment in this field is scarce. Few studies demonstrated that cognitive behavioral therapies can be effective for adults with mild TBI suffering from Acute Stress Disorder, but no research, to date, addressed this question in pediatric population. In the current research we intend to examine the effectiveness of PE in reducing post-traumatic stress symptoms in children and adolescents with m-TBI caused by motor vehicle accident, in comparison to children and adolescents without brain injury.

Sixty children age 6 to 18 attending the Anxiety clinic in Schneider Children's Medical Center of Israel will be included. All subjects will be treated with a manualized 12-18 week Prolonged Exposure protocol. Participants will undergo assessments, which will include interviews, questionnaires and neuropsychological tests concerning symptoms of PTSD, emotional and cognitive functioning. Ratings and neuropsychological testing will be made at baseline and following completion of treatment. Follow up will include questionnaires ratings at 2 weeks, 4 weeks and 12 weeks after completion of treatment.

Eligibility Criteria:
Inclusion Criteria:

For the whole sample:

* Children age 6 to 18
* Language spoken: Hebrew, Arabic
* DSM- IV R diagnosis: PTSD
* Car accident event within past 3 years

For the m-TBI group:

* Any of the following symptoms or experiences occurring during or shortly after the accident: loss of consciousness, dazed, confused, saw stars, headache, dizziness, irritability, memory gap (not remembering injury or injury period), visual loss, abdominal pain\].
* Diagnosis of MTBI within 3 years as confirmed by CT/MRI/fMRI.
* Glasgow coma scale; GCS\<15.

Exclusion Criteria:

* Children presenting with psychotic symptoms
* Children presenting with mental retardation
Transobturator Repair by Vaginal Plastron

The autologous vaginal route consists of repairing the genital prolapse through the vagina using the patient's tissues without a prosthesis. Vaginal prostheses are actually currently prohibited in France \[1, 2\].

The autologous vaginal route is the quickest surgery and it can be done under spinal anesthesia, which constitutes arguments for offering it to elderly and fragile patients. The autologous vaginal approach gives functional and subjective results similar to promontofixation \[2\].

There are many surgical techniques that make it difficult to assess the recurrence rate in the literature. Autologous vaginal surgery provides a good degree of satisfaction for patients despite the risk of recurrence \[3\].

We propose to describe the results of the transobturator cystocele repair by vaginal plastron, a technique which seems reproducible and effective to us.


Eligibility Criteria:
Inclusion Criteria:

* women over 18
* patient who underwent surgery using the transobturator repair by vaginal plastron for correction of anterior prolapse requiring surgical correction of stage equal to or greater than II in the POP-Q classification
* intervention between September 2020 and October 2022
* person having expressed his non-opposition

Exclusion Criteria:

* inability to understand the information given
* person deprived of liberty
* person under guardianship
Ibuprofen 5% Topical Gel CIPT

This study will determine the potential of Ibuprofen 5% Topical Gel and its vehicle gel to cause irritation after repeated topical application to the healthy skin of human subjects under controlled conditions.


Eligibility Criteria:
Inclusion Criteria:

Healthy male and/or female subjects (to be confirmed by medical history) 18 years of age or older, female subjects of childbearing potential and males who are using an acceptable form of birth control, subjects who are free of any systemic or dermatologic disorder

Exclusion Criteria:

Have skin disease at the application site, not willing to stop use of systemic or topical analgesics, corticosteroids, or antihistamines, unwilling or unable to stop use of sunscreens, creams, or similar products on the back during the study
Diagnostic Accuracy of Artificial Intelligence, CBCT, and Clinical Examination in Detecting Number of Root Canals in Conventional and Retreated Maxillary and Mandibular Molars

The study compares the effectiveness of Artificial Intelligence (AI), CBCT, and clinical examination in detecting root canals in upper first, upper second, and lower first molars. Results show AI detects more molars with three or four canals in conventional treatment cases and retreatment cases.

Introduction: Accurate root canal detection is crucial for successful endodontic treatment, particularly in complex molar cases. Conventional methods, such as clinical examination and cone-beam computed tomography (CBCT), have their limitations, as high radiation exposure. Recent advancements in Artificial Intelligence (AI) have shown promise in improving diagnostic accuracy. This study aims to compare the effectiveness of AI, CBCT, and clinical examination using a dental operating microscope (DOM) in detecting root canals in upper first, upper second, and lower first molars, in both conventional and retreatment cases. Methods: CBCT scans from 210 patients requiring non-surgical root canal therapy or re-treatment were selected. The scans were analyzed using three detection methods: clinical examination via DOM, interpretation by two experienced endodontists using CBCT, and an AI convolutional neural network (CNN) software (Diagnocat). The detected number of root canals was recorded and compared across the three methods.

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients who were capable of providing informed consent
* Age between 18 to 40 years old.
* A restorable tooth.

Exclusion Criteria:

* Patients that underwent vital pulp therapies.
* Patients with calcifications in pulp space.
* Open apex/immature roots.
* Teeth restored by full coverage crowns.
* Pregnant women by taking adequate history from patient and pregnancy test that was done in the first visit
Use of Adipose Tissue Derived Mesenchymal Stem Cells for Knee Osteoarthrosis

Adipose tissue derived Mesenchymal Stem cells (ATMSC) will be injected in patients diagnosed with Knee osteoarthrosis

Ten patients from both genders diagnosed with Knee osteoarthrosis, will be enrolled according to specific inclusion and exclusion criteria. These patients will be injected with Adipose Tissue derived Mesenchymal Stem Cells. Then, they are followed by clinical assessment, laboratory investigations as well as magnetic resonance imaging (MRI) of the injected knee.

Eligibility Criteria:
Inclusion Criteria:

Severe KOA stage III or IV by Laurance \& Kellgren staging as judged by Posterioranterior (PA) Xray of the knee joint.

Willing to participate by signing the informed consent

Exclusion Criteria:

* Sublaxation beyond 20 degrees of the bones of the knee joint
* Oral anticoagulants or heparin therapy
* Heart failure or arrhythmia
* Body Mass Index \> 35
* Uncontrolled Diabetes Mellitus.
* Evidence of Infectious Diseases.
* Active infection
* Malignancy
* Pregnancy
* Anemia less than 11g/dl or thrombocytopenia less than 100,000 or leucopenia less than 3000.
* Unreliable patients
* Non-resident in Jordan
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

A clinical trial of AAV5-hRKp.RPGR vector for participants with X-linked retinitis pigmentosa (XLRP)


Eligibility Criteria:
Inclusion Criteria:

* Male or female, 3 years of age or older, has XLRP confirmed by a retinal specialist and has a predicted disease-causing sequence variant in RPGR confirmed by an accredited laboratory.

Exclusion Criteria:

* None
A Trial of HRS-1893 in Patients With Obstructive Hypertrophic Cardiomyopathy

The study is being conducted to evaluate the efficacy, and safety of HRS-1893 for obstructive hypertrophic cardiomyopathy


Eligibility Criteria:
Inclusion Criteria:

1. Age 18-85 years old, gender unlimited;
2. The diagnosis was obstructive hypertrophic cardiomyopathy.
3. Echocardiographic laboratory tests showed LVEF≥60%;
4. No previous left ventricular systolic dysfunction at any time (LVEF \< 45%);
5. Understand the study procedure and sign the informed consent in person, willing to strictly follow the clinical study protocol to complete the study.

Exclusion Criteria:

1. Known or suspected invasive, genetic or storage diseases (e.g. Noonan syndrome, Fabre's disease, amyloidosis) that cause cardiac hypertrophy (similar to oHCM);
2. Previous left ventricular systolic dysfunction at any time in the clinical course (LVEF \< 45%);
3. Previous history of aortic stenosis or subaortic fixed stenosis;
A Study to Assess the Pharmacokinetics, Safety, and Efficacy of Two Doses of Bimekizumab in Adolescent Study Participants With Moderate to Severe Plaque Psoriasis

The purpose of the study is to assess th pharmacokinetics (PK) of bimekizumab administered subcutaneously (sc) in adolescents with moderate to severe plaque psoriasis (PSO).


Eligibility Criteria:
Inclusion Criteria:

* Participant must be ≥12 to less than 18 years of age at the time of signing the informed consent/assent according to local regulation
* Participant has had a diagnosis of moderate to severe plaque psoriasis (PSO) for at least 3 months prior to the Screening Visit and:

  1. Body surface area (BSA) affected by PSO ≥10%
  2. Investigator's Global Assessment (IGA) score ≥3 (on a scale from 0 to 4)
  3. Psoriasis Area and Severity Index (PASI) score ≥12 OR
  4. PASI score ≥10 plus at least 1 of the following:

  i. Clinically relevant facial involvement ii. Clinically relevant genital involvement iii. Clinically relevant hand and foot involvement
* Participant must be candidate for systemic PSO therapy and/or photo/chemotherapy
* Body weight ≥30 kg and body mass index for age percentile of ≥5 at Baseline
* Male or female A female participant will be eligible to participate if she is not pregnant, not breastfeeding, and a woman of childbearing potential (WOCBP) agrees to follow the contraceptive guidance
* Capable of giving/having parent(s) or legal representative provide signed informed consent/assent (where appropriate)

Exclusion Criteria:

* Participant has a presence of guttate, inverse, pustular, or erythrodermic PSO or other dermatological condition that may impact the clinical assessment of PSO
* Participant has a history of inflammatory bowel disease (IBD) or symptoms suggestive of IBD
* History of active tuberculosis unless successfully treated, latent TB unless prophylactically treated
* Participant has an active infection or history of infections (such as serious infection, chronic infections, opportunistic infections, unusually severe infections)
* Participant has laboratory abnormalities at Screening
* Participant has experienced primary failure to one or more interleukin-17 (IL-17) biologic response modifier OR primary failure to more than 1 biologic response modifier other than an IL-17 biologic response modifier
* Presence of active suicidal ideation, or positive suicide behavior
* Participant has been diagnosed with severe depression in the past 6 months
Representations and Prevention of Cancers in Schools

The main objective is to develop an educational program and to measure the impact on social representations identified as acting in the prevention of cancer. Child should write, draw and speak about cancer signifiance to identify individual conceptions and representations of health and cancer in children aged 9 to 12 years in school.

The stages are :

* Selection of forms
* Technique of write and draw and interview by a school nurse
* Data analysis

Eligibility Criteria:
Inclusion Criteria:

* Aged between 9 and 12

Exclusion Criteria:

* Boy or Girl ages over 12 years and under 9 years
* Children refusal
Sleep Apnea Syndrome in Obese Women During Pregnancy

Excess weight or obesity is associated with an increased risk of health disorders: high blood pressure, diabetes, cardiovascular risks, dyslipidemia and sleep apneas. During pregnancy in obese women, the risk of preeclampsia increases by three and the risk of fetal death in utero by five. Snoring and Obstructive sleep apnea (OSA) may be associated with increased risk of adverse pregnancy outcomes, including maternal cardio pulmonary status, fetal heart rate and fetal acidosis-basis status by recurrent upper-airway obstruction, hypoventilation, and intermittent nocturnal hypoxia. Reports in pregnancy have identified in association with OSA and preeclampsia, intrauterine growth restriction and stillbirth.

The prevalence of OSA among women is estimated to be 2-5%, but it remains underdiagnosed during pregnancy. In sleep apnea syndrome, a few data have shown better pregnancy and fetal outcome with the use continuous positive airway pressure (CPAP) therapy.

the hypothesis is in obese pregnant women that there could be a significant association between sleep apnea syndrome and hypertensive disorders, preeclampsia and adverse fetal outcomes This is a prospective study of Women with a body mass index of 35 kg.m2 or greater. The aim of this study is to determinate the prevalence of sleep apnea syndrome in obese pregnant women and the benefit of CPAP on the maternal and fetal outcome.


Eligibility Criteria:
Inclusion Criteria:

* age \>18 years
* BMI \> 35
* \> 24th weeks of pregnancy
* informed consent,
* health assurance

Exclusion Criteria:

* no informed consent
* twin pregnancy or more
* no health assurance
Effects of Early Sleep After Action Observation Therapy on Balance in Elderly

The study aims at investigating the effects of an early sleep window after Action Observation Therapy (AOT) on balance in elderly. Forty-five healthy-like elderly will be enrolled and randomized into 3 groups (AOT-sleep, AOT-control and Control) performing a 3-week AOT. AOT-sleep and AOT-control will be asked to watch video-clips showing motor contents before sleeping or at least 12 hours before sleeping, respectively, whereas Control will be asked to watch landascape video-clips before sleeping. Participants will be assessed before and after training and at 1 month follow-up for balance outcomes.


Eligibility Criteria:
Inclusion Criteria:

* Ability to walk for at least 100 meters with no assistance or aids

Exclusion Criteria:

* Musculoskeletal disorders able to affect balance
* Traumas and/or injuries and/or surgery at the level of the lower limbs, spine in the previous year
* Sleep disorders
* Drugs able to affect sleep
* Dementia or cognitive decline (MCI)
* Psychiatric or neurological disorders