cyrilzakka/clinical-trials huggingface dataset:
Laser Versus Ultrasonic Lithotripsy in Percutaneous Nephrolithotomy for Staghorn Stones

This study will be conducted to compare the results of Laser and ultrasonic lithotripsy in disintegration of staghorn stones during percutaneous nephrolithotomy.

Patients with complete staghorn stones who are eligible to percutaneous nephrolithotomy (PNL) will be randomized between two groups.

Group 1: will undergo Laser lithotripsy during PNL Group 2: will undergo ultrasonic lithotripsy during PNL

Eligibility Criteria:
Inclusion Criteria:

1. Complete staghorn stones (filling the renal pelvis and branching to 3 major calyces
2. Age: 18-70 years

Exclusion Criteria:

1. Congenital renal anomalies such as horse shoe kidney.
2. Contraindications to PNL such as bleeding tendency and uncontrolled hypertension.
3. Associated pathological features requiring open intervention such as UPJO
4. Partial staghorn stones (filling the renal pelvis and branching to 2 major calyces)
5. Giant staghorn stone (very large staghorn stone that branch and re-branch in hugely dilated calyceal system)
Low Molecular Weight Heparin and Aspirin in the Treatment of Recurrent Pregnancy Loss: A RCT

To compare the livebirth rate of women with recurrent pregnancy loss and autoantibodies randomized to either low molecular weight heparin plus aspirin versus aspirin alone.

Previous studies of these therapeutic regimens in the population of recurrent pregnancy loss and autoantibodies, have not provided conclusive evidence of their efficacy due to small sample size and/or weak study design. We undertook a RCT of low molecular weight heparin plus aspirin versus aspirin alone to investigate if the low molecular weight heparin treatment resulted in an increased rate of livebirths as compared to treatment with aspirin alone.

Eligibility Criteria:
Inclusion Criteria:

* history of two or more unexplained consecutive pregnancy losses prior to 32 weeks
* presence of one of the panel of autoantibodies/thrombophilia markers
* confirmed pregnancy

Exclusion Criteria:

* SLE
* known peptic ulcer disease
* sensitivity to ASA or heparin
* previous thrombotic event
* geographic distance from clinic
* failure to consent
Opioid Use After Urogynecologic Procedures: Using a Predictive Calculator

The purpose of this study is to determine if the investigators can precisely predict how much pain medication the subjects will need after surgery using a special calculator that was developed for this purpose.


Eligibility Criteria:
Inclusion Criteria:

* Age 18-89
* Able to provide informed consent
* Patients undergoing any of below urogynecologic procedures

Included urogynecologic procedures:

1. Sacrocolpopexy - robotic or laparoscopic

   1. With or without hysterectomy
   2. With or without salpingo-oophorectomy
   3. With or without anterior colporrhaphy
   4. With or without posterior colporrhaphy/perineorrhaphy
   5. With or without midurethral sling
2. Sacrospinous ligament fixation

   1. With or without hysterectomy
   2. With or without salpingo-oophorectomy
   3. With or without anterior colporrhaphy
   4. With or without posterior colporrhaphy/perineorrhaphy
   5. With or without midurethral sling
3. Uterosacral ligament suspension - robotic, laparoscopic, or vaginal

   1. With or without hysterectomy
   2. With or without salpingo-oophorectomy
   3. With or without anterior colporrhaphy
   4. With or without posterior colporrhaphy/perineorrhaphy
   5. With or without midurethral sling
4. Colpocleisis

   1. Lefort colpocleisis
   2. Complete colpectomy with colpocleisis
5. Isolated anterior and/or posterior colporrhaphy

Exclusion Criteria:

* Non-English speakers
* pre-operative diagnosis of cancer
* scheduled for any concurrent non-urogynecologic procedure (ex: abdominoplasty)
* \<18 years or \>89 years of age
* unable to provide informed consent
Collecting and Storing Tissue Samples From Patients With Head and Neck Cancer

RATIONALE: Collecting and storing samples of tissue, blood, and saliva from patients with cancer to study in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tissue samples from patients with head and neck cancer.

OBJECTIVES:

* Establish a tissue/specimen bank of biologic specimens collected from patients with proven or suspected head and neck cancer.
* Establish a database to link materials acquisition and pathologic and clinical information on these patients.
* Correlate clinical-pathological findings on these patients with future scientific studies using the patient database.
* Test new hypotheses as they emerge.

OUTLINE: This is a prospective, multicenter study.

Patients enrolled on active Radiation Therapy Oncology Group clinical trials undergo biopsy or surgical resection of head and neck tumors or premalignant lesions at participating institutions. Tissue and other specimens collected at the time of biopsy or surgery are submitted to the Head and Neck Cancer Tissue/Specimen Bank which acts as a central repository for processing, storing, and preserving patient specimens for translational research. Tissue samples include paraffin-embedded blocks or fresh or frozen samples of normal squamous mucosa, tumors, or premalignant lesions of the upper aerodigestive tract. Other specimens for tissue banking include serum, plasma, and lymphocytes isolated from peripheral blood, as well as samples of patient saliva. Cells obtained from tissue bank specimens may also be used to establish cell lines for future research.

PROJECTED ACCRUAL: An unlimited number of specimens will be accrued for this study.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Confirmed or suspected head and neck cancer

  * Primary site recurrence allowed
* Potentially eligible for or participating in an active Radiation Therapy Oncology Group treatment clinical trial

PATIENT CHARACTERISTICS:

* Zubrod performance status 0-1

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* Concurrent radiotherapy, drug therapy, biopsy, or surgery allowed
Assessment of SSD in Outpatients by Using SSS-CN

About 70-80% of patients with somatic symptom disorder (SSD) visit the general medical hospital instead of psychiatric or other mental health settings. The current self-reporting questionnaires are neither sufficiently considering companioned anxiety or depression nor validated for monitor the treatment efficacy of such group. The Somatic Symptom Scale-China (SSS-CN) is developed due to the urging clinical demanding in general hospital. The study aims to investigate whether the SSS-CN could serve as a timely and practical instrument to detect SSD and assess the severity of the disorder.

One of the most common medical conditions seen in general hospital is somatic symptoms disorder (SSD). As the disorder is characterized by the prominent attention to somatic concerns, patients mainly present initially in medical rather than mental health care settings. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is currently the "gold standard" for the diagnosis of SSD, but it is clinically hard to follow. Thus, It is more clinically practical to detect a disorder by self-administered questionnaires, that patients can score symptoms according to their own condition and severity in a short time. However, the current self-reporting questionnaires, such as the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder Scale-7 (GAD-7), and the Patient Health Questionnaire-15 (PHQ-15) are neither sufficiently considering companioned anxiety or depression nor validated for monitor the treatment efficacy of SSD patients.

The Somatic Symptom Scale-China (SSS-CN) is developed based on DSM-5 to assess SSD, and it is an abbreviated 20-item version of somatic symptoms that can be entirely self-administered by the patient, but its assessment value has not yet been widely tested. The study aims to investigate whether the SSS-CN could serve as a timely and practical instrument to detect SSD and assess the severity of the disorder.

Eligibility Criteria:
Inclusion Criteria:

1. age 18-80 years old;
2. patients who have no previous diagnosed somatic disease;
3. patients without systemic disease that can account the physical discomfort;
4. patients who agree to take the checklists and undertake assessment from a physician.

Exclusion Criteria:

1. patients who have lost their self-assessed abilities or refuse to participate in;
2. patients who have been previously confirmed serious mental disorders, mental retardation or dementia;
3. patients who are taking anti-anxiety agents or anti-depression agents;
4. patients who are unable to complete at least 1 time follow-up.
Retrospective Evaluation of Infections After Delivery

In general, transabdominal and transvaginal ultrasound represent the first imaging method in the study of suspected postpartum infections because of its good sensitivity, low cost, and high safety for patients (in fact, it allows the patient to be studied at the bedside, even in clinically unstable patients, it is well tolerated by patients, and it has no risks). CT has an excellent sensitivity in the diagnosis of postpartum infections, however, it has some drawbacks: it is not an examination that can be performed in clinically unstable patients, it cannot be performed at the patient's bedside, it has high costs, and it involves the administration of a significant dose of radiation . There are conflicting data in the literature regarding which examination is most useful for the diagnosis/management of infections in postpartum. Therefore, the investigators want to evaluate whether ultrasound alone, compared with management with combined ultrasound and CT scan, is a useful and sufficient diagnostic tool for the diagnosis and management of postpartum infectious complications.

Cases of infection recorded as a result of these parts will be reviewed. Laboratory tests and clinical data of these will be reviewed. Instrumental, ultrasound and CT images taken in the postpartum for diagnostic confirmation and subsequent follow-up will also be reviewed.

For each patient, information will be collected on:

* Age, weight, height
* Previous pregnancies and their outcome
* Pregnancy that arose spontaneously or through Medically Assisted Procreation techniques
* Conditions concomitant or complicating pregnancy
* Pregnancy outcome (spontaneous delivery or cesarean section)
* Laboratory tests
* Clinical data collected during hospitalization (vital parameters, symptoms, any medications administered)
* Radiologic (CT) or ultrasound (transabdominal and/or transvaginal) investigations performed during the hospital stay, in continuation-iter or in a subsequent hospitalization: name and model (and probe, for ultrasound examinations) of the equipment used will be specified for each examination performed.

Eligibility Criteria:
Inclusion Criteria:

* Women aged 18 years or older
* Diagnosis of postpartum infection (within 30 days after delivery).

Clinical diagnosis is established by the following criteria (two or more of the following):

* Temperature \>38°C or \<36°C
* HR \>100 bpm
* FR \>20 respiratory acts/min or PaCO2 \<32mmHg
* GB \>14 x 109/dL or \<4 x 109/dL
* EGA: lactates \>2mmol/L (or 18 mg/dL)
* PCR \>2DS from normal value
* Procalcitonin \>2DS from normal value or positive laboratory culture result for the presence of bacteria (urinoculture, peritoneal fluid culture, abscess...).
* obtaining informed consent
* Women who have had at least one ultrasound (transabdominal and/or transvaginal) and one CT scan for suspected postpartum infection

Exclusion Criteria:

* Women with localized or systemic infection following infection unrelated to delivery or incision site (in case of cesarean section), such as pneumonia, mastitis, influenza, COVID-19.
Brain Imaging in Babies Study

The aims of the BIBS Study

The Brain Imaging in Babies study (BIBS) aims to improve understanding of how a baby's brain develops from before birth, up until 3-4 years of age. Working with children from a variety of backgrounds and communities, the investigators use a combination of state-of-the-art diagnostic tools such as MRI scans alongside traditional behavioural assessments to capture the earliest information on infant brain development.

The focus of the BIBS study

MRI scanning is a safe way of producing detailed images using strong magnetic fields and radio waves. It does not use X-ray. Along with learning more about brain development in general, the investigators also try to identify features that may in future help predict whether a child will or will not develop traits of conditions such as Autism Spectrum Disorder (ASD) or Attention Deficit Hyperactivity Disorder (ADHD). Long-term, this may help target useful interventions early on, helping children who are most in need.

Since COVID-19 arrived in the United Kingdom (U.K.) in 2020, the investigators have been given ethical approval to include testing for this infection in the mothers and children participating in the study. This may provide an opportunity to better understand how mother and baby respond to infections. The investigators particularly welcome mothers who have had a positive COVID-19 test during their pregnancy to join the study.


Eligibility Criteria:
Inclusion Criteria:

* Pregnant mothers with and without confirmed COVID-19
* Infants with and without an immediate family history of Autism Spectrum and neurodevelopmental conditions
* Based in England, UK

Exclusion Criteria:

* based on further screening
Nebulized Dexmedetomidine for Post-Anesthesia Delirium in Preschool Children

Analyzing the effectiveness of nebulized dexmedetomidine 2 mcg/kg in reducing the incidence of post-anesthesia delirium in preschool children undergoing elective surgery with sevoflurane inhalation general anesthesia.

Researchers will compare nebulized Dexmedetomidine to a placebo (a look-alike substance that contains no drug) to see if the drug can reduce post anesthesia delirium incidence.

participant will : Nebulized with the anesthetic drug dexmedetomidine at a dose of 2 mcg/kg body weight, diluted to 3 ml with 0.9% normal saline, is administered before the induction of anesthesia in the reception area.

After the anesthesia, primary data collection is conducted by recovery room staff who are blinded to the treatment and control groups. Data includes scores or levels of post-anesthesia delirium or agitation assessed using the pediatric anesthesia emergence delirium score (PAED score) in the recovery room.

Eligibility Criteria:
Inclusion Criteria:

* Pediatric patients aged 2 to 6 years old.
* Planned general anesthesia using inhalation sevoflurane with endotracheal tube techniques
* Parents agree to participate in the study

Exclusion Criteria:

* Pediatric patients with \> ASA II.
* Difficult airway management.
* Emergency surgery.
* Congenital abnormalities of vital organs.
* Malnutrition
* history or diagnosed with mental or cognitive disorders.
* History of upper respiratory infection within 2 weeks before the procedure.
* History of allergy to dexmedetomidine.
* Surgery duration estimation exceeding 180 minutes.
* Parents refuse to participate in the study
Amniotomy for Second-trimester Pregnancy Termination

The termination of abortion is an important issue that has many controversies. The most common time of serious abortion-related complications is the second trimester. Missed abortion is one of the most common indications of termination of pregnancy in the second trimester. Misoprostol and mifepristone are effective drugs for induction of abortion but these drugs are now expensive, and non-available in many developing countries.

The effectiveness of Foley's catheter balloon on cervical ripping for mid-trimester pregnancy termination has been proved before. It can effectually shorten the time of the expulsion of the fetus. Amniotomy defines as an artificial rupture of the membranes; it is an ordinary obstetric practice used mainly in the induction of labor, with good results and less morbidity. The obstetricians used to combine amniotomy with other methods such as prostaglandins or oxytocin to induce labor in a woman with an unfavorable cervix.

Despite plenty of studies that investigated the role of amniotomy for induction of labor but the studies which addressed the role of amniotomy in the induction of second-trimester abortion are very scarce in the literature.


Eligibility Criteria:
Inclusion Criteria:

* Women aged 18-40 years old.
* Women who are pregnant in singleton mid-trimester missed abortion (18-26 weeks).
* Bishop's score is ≤ 4.

Exclusion Criteria:

* Women who delivered before by classic caesarian section or had a history of -myomectomy, hysteroscopic uterine surgery, or cervical surgery like conization.
* Women with multiple gestations.
* Women with ultrasonography evidence of low amniotic fluid volume.
* Women with rupture of fetal membranes.
* Women with evidence of low implanted placenta by ultrasound.
* History or laboratory evidence of intra-uterine infection.
* History is suggestive of latex allergy.
* Women with severe anemia, hypertension, diabetes, or with coagulopathy.
Interactive Technology for Media Literacy Drug Prevention in Community Groups

This Phase II STTR will evaluate an interactive, self-paced, e-learning media literacy intervention, REAL media, to prevent youth substance use among youth in the 4-H organization. Participating 4-H clubs will be randomly assigned to use the curriculum or continue current practices with the option for delivery at the end of the study. 4-H members (ages 13-15) will complete a pretest, immediate posttest and follow-up posttests at 3 and 9 months to assess effects.

REAL media is an interactive, self-paced, e-learning media literacy curriculum that prevents adolescent substance use among 13-15-year-old teens. The program consists of 5 levels. Levels 1 to 4 are 15-25 minutes; level 5 allots time for message production done offline. Activities lead students to engage in critique and analysis of arguments present/absent from pro-ATOD and other popular product messages and to begin the process of refuting and counter-arguing these messages. These skills are reinforced in level 5 using an active involvement strategy in which youth plan and produce anti-ATOD messages. Users first plan their message via an online worksheet, which requires engagement with and application of media literacy concepts rather than focus exclusively on technology and/or production features. Next, participants design their posters/videos and upload their messages to a social media site as part of a contest, where they recruit peers and family to like or comment on their message.

Eligibility Criteria:
Inclusion Criteria:

* 4-H members and leaders must belong to a participating club in Pennsylvania, Ohio, New Jersey, West Virginia, or Maryland
* members must be between the ages of 13-15
* club leaders must be at least 21 years of age
* written parental consent and assent from members
* written consent from club leaders (online assent)

Exclusion Criteria:

* the inability to speak or read American English
* access to and the ability to use a computer, or navigate the Internet
* for youth, lack of parental consent/youth assent/leader consent
Android Mobile Devices to Assist Routine Anticipation for Autistic Children

The objective of this work is to develop an application to run on a mobile device Android tablet that features visual routines for autistic children.

Autism is a disorder characterized by social deficits, and among others by changes in communication. The diagnosis of this disorder remains accomplished by direct assessment the individual's behavior, according to specific clinical criteria present the classification systems of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). Therapists teach autistic to communicate with the help of symbols and auxiliary anticipation and communication routines, usually using the Picture Exchange Communication System (PECS), or photos. However these are presented in transition PECS cards and do not follow the children in activities that develop outside the school environment. The objective of this work is to develop an application to run on a mobile device Android tablet that features the visual routines.

In this way the routines can be accessed outside the school environment. This technology is easy to use and facilitates data entry by touching the screen, was developed using the Unified Modeling Language (UML), Javascript, Apache Web server and Web browser Chrome. The application validation, will be held with 10 autistic and 2 teachers from the center of inclusion and support for autistic. Teachers should insert the activities programmed for each autistic student. Tablet in student performance in communicating with this tablet will be measured. Parents or guardians knowledge with the PECS system will be trained and will be evaluated on their autonomy inserting images, audio and subtitles. The application should aid communication, cause the autistic understand the sequence of events in daily life, decreasing their aggression because of not knowing what will be their next activity. Participation in this research poses no risk or harm the concerned person. If during the research participant decides not anymore have the freedom to do so without incurring any damage you. The technical validation proposal is necessary for it to be used by people with autism. If validated in a positive way, the technique could improve the quality of life of these people and their families.

Eligibility Criteria:
Inclusion Criteria:

* Have a diagnosis of autism development by DSM-IV
* Have sufficient motor skills to perform operations on a tablet
* Be aware of PECS
* Children should be accustomed to the visual routines used in

Exclusion Criteria:

* Have visual impairment
Use of Interlocking Detachable Coils System in Embolization of Peripheral Arterial Embolization

The purpose of this study is to evaluate the safety and efficacy of interlocking detachable coils system in the treatment of Chinese patients with embolization of peripheral arterial in comparison with Interlock Fibered IDC Occlusion System

This is a prospective, multicenter, open-label, non-inferiority, randomized controlled clinical trial. The plan is to recruit patients with peripheral arterial disease requiring embolization and then perform peripheral arterial embolization based on randomization using devices in the experimental group or control group. This trail will be conducted in a number of experimental institutions in China, and a total of 116 subjects are planned to be enrolled. All subjects were treated with the interlocking detachable coils system and were evaluated during surgery and before discharge from the treatment of experimental or control devices, followed up at 1 month, 3 months, and 6 months after surgery.

Eligibility Criteria:
Inclusion Criteria:

1. Age 18-80 years;
2. Subject diagnosed with peripheral arterial embolization by preoperative imaging (CTA);
3. The target vessel can be embolized in one operation;
4. The visual diameter of the target blood vessel is 5mm-30mm;
5. Subjects or their legal representatives can understand the purpose of the trial, voluntarily participate and sign the written informed consent, and can be followed up.

Exclusion Criteria:

1. Definite allergy, resistance or contraindication to antiplatelet agents, anticoagulants, contrast agents and/or anesthetics;
2. Definite allergy to platinum, tungsten and/or any substance in the test coil;
3. Subjects are not suitable for anesthesia or endovascular surgery, such as those with severe respiratory, heart, lung, liver, kidney disease or coagulation disorders (such as hemophilia);
4. The target vessel has undergone previous surgery and/or major cardiovascular surgery within 3 months;
5. The target aneurysm is dissecting aneurysm, infected aneurysm, ruptured aneurysm, and aneurysm caused by connective tissue disease;
6. Women who are pregnant or breastfeeding;
7. Subjects who are participating in clinical trials of other drugs or devices that have not reached the end point of the trial;
8. The researcher believes that it is not suitable to participate in the trial.