cyrilzakka/clinical-trials huggingface dataset:
Ultrasound-Guided Hip Joint Cooled Radiofrequency Denervation

Hip osteoarthritis (HOA) is a common cause of pain and disability in aging population. Conservative treatment is based on lifestyle modifications, physical therapy, analgesic and anti-inflammatory medications and intra articular injections. This Prospective Pilot Study aims at investigating the efficacy of Ultrasound-Guided Cooled Radiofrequency Hip Denervation as a treatment offered to patients with HOA.

Radiological prevalence of HOA is very high. Hip denervation (HD) is a known palliative procedure that was initially performed as an open surgery. The role of the obturator, femoral and sciatic nerves in hip joint innervation was discovered. Several small clinical and anatomical studies addressed feasibility and benefits of the radiofrequency hip denervation (RFHD). Ultrasound guidance may eliminate equivocality of previously published techniques and provide precise image guidance as it a is logical and anatomically sound approach when procedural targets include soft tissue, such as nerves, tendons and joint capsule. None of these structures can be localized under routine fluoroscopy. Ultrasound is a bedside imaging tool that has been accepted as safe and reliable. In two meta-analyses, the use of real-time two-dimensional ultrasound for the placement of CVCs substantially decreased mechanical complications and reduced the number of attempts at required cannulation and failed attempts at cannulation compared with the standard landmark placement. Pertinent to the proposed study, recent systematic review and meta-analysis of the accuracy of US-guided versus landmark-guided hip joint injections revealed that US-guided injections are significantly more accurate than those that are landmark-guided. The significance of this study lies in its potential to improve functional activity and pain control in patients with HOA. Also, it may eventually lead to a decrease in patients resorting to Total Hip Arthroplasty (THA) as an ultimate end solution for HOA.

Eligibility Criteria:
Inclusion Criteria:

* Primary degenerative osteoarthritis of hip joint
* Pain pre-intervention qualified as at least moderate with functional limitation moderate/severe.
* Radiological confirmation of hip osteoarthritis
* Failure of conservative therapy to control symptoms, defined as the persistence of at least moderate with functional limitation moderate/severe pain that has been refractory to prescribed medications, and other modalities, such as physical therapy and intraarticular injections. Intolerable side effects of medications and contraindications to specific methods will be also considered as a failure of the conservative therapy.
* Positive articular branches analgesic block, defined as \>50% improvement in pain and function for at least 2 hours

Exclusion Criteria:

* Non-English speakers
* Daily dose of opioids more than 90 MEQ
* Body Mass Index (BMI) \> 30
* Uncorrectable coagulopathy
* Local and systemic infection
* Inability to obtain ultrasound image of ventral acetabulum
* Documented prior Anaphylactic Reaction to Contrast Agent
* Pregnancy
PVP-I Nasal Sprays and SARS-CoV-2 Nasopharyngeal Titers (for COVID-19)

The study aims to determine the safety and efficacy of povidone-iodine (PVP-I) containing nasal sprays as compared to isotonic saline nasal sprays in COVID-19 positive patients. The primary outcome measure is SARS-CoV-2 viral titers in the nasal cavity and nasopharynx. In vitro studies have shown PVP-I to be highly virucidal against the viruses which cause SARS and MERS. Additionally, clinical studies have shown PVP-I saline sprays to be well tolerated in human subjects. PVP-I oral rinses and sprays have been trialed as methods to reduce the incidence and symptoms of viruses which cause the "common cold."


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of COVID-19 by lab test within 5 days of study participation

Exclusion Criteria:

* Allergy to "iodine," shellfish, or food dye
* Receiving intranasal steroids
* Sinus surgery within 30 days of beginning the study
* Intubated at the time of enrollment
* Pregnancy
* Participation in other COVID-19 studies - to be determined on a case by case basis
Impact of Football Matches on the Emergency Admissions of a Level III Maternity During EURO 2016

Attendances at an emergency department (ED) are often considered to depend on different factors such as moonlight, welfare checks, weather, and major sporting events. Data regarding effects of large sporting events on the workload of ED often assessed decreased patient volume, especially male use. Currently, no data are available on the effect of major televised sporting events on obstetrical visits. The aim of this study is to examine whether televised soccer games from a major sporting tournament, (Euro 2016) influence the level of attendance at an obstetrical ED and could have implications for women's welfare.

In the summer of 2016, France hosted the largest European sporting event of the year 2016: the European Football Championships (Euro 2016). A total of 51 games were played over a month, bringing together the biggest European teams. An observational, retrospective study is conducted during this period on the number of emergency visits in a French tertiary Maternity hospital (Maternity of Nancy).


Eligibility Criteria:
Inclusion Criteria:

All female patients admitted urgently to the Regional Maternity Hospital between June 10 and July 10, 2016

Exclusion Criteria:

* refusal of the patient
* information and understanding impossible
Benefits of Telemedicine in CPAP Treatment

Continuous positive airway pressure (CPAP) is the first choice of treatment for moderate to severe obstructive sleep apnea syndrome (OSAS). Although adherence is critical for achieving a good treatment effect, and early intervention if treatment problems emerge is important for achieving good adherence, information on patient compliance is usually based on assessment of the first few weeks of treatment. Telemedicine technology allows for monitoring of CPAP pressure, air leaks, apnea-hypopnea index (AHI) and compliance on a daily basis and could therefore be an option allowing for adequate support and quick response if a patient has problems with the treatment. In addition, improving early experiences of CPAP, identifying patients in need of more intensive support could potentially improve adherence but also reduced cost of care, and increased patient satisfaction.

The proposed study will recruit 200 OSAS patients starting CPAP treatment; 100 patients randomized to afterwards receiving telemonitoring in combination with telephone calls, and 100 patients randomized to receiving usual office visits. All patients will in addition answer questionnaires on sleep and health, quality of life, and patient satisfaction after the first CPAP information visit and then again after 6 months of treatment. At time of follow-up all patients will also answer questionnaires on side effects of CPAP. Health economic variables will also be measured throughout the testing period.

The study will provide valuable information regarding benefits of telemonitoring in clinical work with CPAP therapy. Implementation of telemedicine-based monitoring of CPAP therapy may be an important part of increasing adherence among patients but also in the development of a more cost-effective care as it can provide clinics with increased treatment capacity and follow-up of both new and established patients. It would further improve the care for these patients who often have a lifelong treatment, which aims to reduce the risk of developing cardiovascular disease or premature death.


Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with OSA and scheduled to receive CPAP treatment

Exclusion Criteria:

* Patients not understandning Swedish
* Patients not eligible for CPAP start within a group session.
Electronic Health Technology for Assessment of Physical Activity and Eating Habits in Children and Adolescents Who Are Overweight and Those With Obesity

Aims: During the last decades overweight/obesity has increased markedly. They are associated with a high risk for diabetes and death. Effective intervention is mandatory. Following participation in treatment programmes children/adolescents often fail to reach sufficient long-term weight reduction. The present trial aims to integrate telemedical support in therapy to improve long term outcome.

Methods: All children/adolescents with overweight/obesity were included (n=66,age 13.9±2.6 years, body mass index \[BMI\] 31.2±5.4kg/m², body mass index standard deviation score \[BMI-SDS\] 2.41±0.6) admitted to our hospital 04-03/2009. To asses physical activity and eating habits electronic health technology was used (Fraunhofer-Institute). The system consists in a motion sensor integrated in a mobile phone(DiaTrace). The system analyses kind, intensity and duration of physical activity and eating habits.


Eligibility Criteria:
Inclusion Criteria:

* All children/adolescents with overweight/obesity were included admitted to our hospital
Acetabular Fracture Reduction Assessment

It is widely accepted in the literature that quality of acetabular fracture reduction is one of the most important factor for the outcome. To obtain best results, anatomical reduction has to be obtained. Intra-operative radiographic assessment depends mainly on plain x-ray. Plain x-ray alone is not enough for post-operative assessment as it depends mainly on reduction of the dome with concentricity of the hip.

It is widely accepted in the literature that quality of acetabular fracture reduction is one of the most important factor for the outcome. To obtain best results, anatomical reduction has to be obtained. Intra-operative radiographic assessment depends mainly on plain x-ray. Plain x-ray alone is not enough for post-operative assessment as it depends mainly on reduction of the dome with concentricity of the hip. Complex fractures with multi-fragmentary fracture pattern, impacted fragments (marginal or roof), fractures with osteo-chondral loss and associated head of femur injuries, pose problems with reduction assessment using both Plain x-ray and CT due to lack of clear standardized way of assessment. Matta criteria has been used widely in the literature for assessment, however it lacks some important criteria which directly related to the functional outcome. Few papers in the literature address this problem and reporting some ways for assessment but with lack of testing and reproducibility.

Since there is in our level 1 trauma center a lot of cases of acetabular fractures that is admitted yearly to our center Purpose of our study is to use those methods for our cases in order to test their validity and reproducibility

Eligibility Criteria:
Inclusion Criteria:

* Isolated displaced acetabular fractures
* Skeletally mature patients

Exclusion Criteria:

* Skeletally Immature
Feasibility of Reducing Cardiovascular Disease Risk Factors in Hispanics Through a Family-Based Community Intervention

The purpose of this study is to evaluate the feasibility of a 6-month family-based community intervention to mitigate cardiovascular disease risk factors in Hispanic families in northern Colorado as measured through biometric screenings, body composition, physical activity, and health knowledge.

The current project aims to leverage the UCHealth Healthy Hearts Family Program to provide a free, non-insurance-based 1-year cardiovascular disease (CVD) prevention and wellness program to Hispanic Colorado families. This program includes an interactive educational class series, baseline and quarterly biometric screenings, and optional consultations with an Exercise Physiologist and a Dietitian. This program takes a novel approach to preventative care by incorporating the family unit with the intention of having the child be the agent of change. The long-term goals of this project are to significantly improve CVD risk factors among participating families and to disseminate study findings to inform developing and current outreach programs to offer effective CVD prevention programs for Hispanic citizens. This work may ultimately lead to more Hispanics being served through new or existing programs, therefore expanding important preventative community health interventions into this underserved population.

Eligibility Criteria:
Inclusion Criteria:

* At least one member of the family unit self-identifies as Hispanic
* At least 13 years of age

Exclusion Criteria:

* Unwilling to wear Fitbit devices daily for 6 months except when charging and sleeping
* Cannot read or understand either English or Spanish
* Cannot return to screening location to perform the minimum of the baseline, 3-month and 6-month follow-up screenings
* Children or adolescents will be excluded from this project without a minimum of one accompanying parent or guardian
Racial Disparities in Pneumococcal Vaccination in Managed Care

The goal of the study was to determine effectiveness of a telephone reminder to increase pneumococcal vaccination in a managed care population.

Patients randomized to the intervention arm received a telephone call from managed care nurses asking about their pneumococcal vaccination status and whether they would like to be vaccinated. We compared six month follow-up of pneumococcal vaccination in electronic medical records for the intervention versus control group. We tested the percent vaccinated in each randomization arm using chi-square tests for proportions.

Eligibility Criteria:
Inclusion Criteria:

- recommended for pneumococcal vaccination according to age or medical comorbidity

Exclusion Criteria:

- already known to have received pneumococcal vaccine
Evaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer

This study evaluates the use of Targretin capsules (bexarotene) in combination with standard chemotherapy for the treatment of metastatic Non-Small Cell Lung Cancer (NSCLC) in patients who have not yet received chemotherapy for their lung cancer.

This study evaluates the use of Targretin capsules (bexarotene) in combination with Carboplatin and Paclitaxel for the treatment of metastatic non-small cell lung cancer in patients who have not yet received chemotherapy for their lung cancer. Every patient receives a platinum-containing chemotherapy every three weeks for at least four chemotherapy cycles (approximately four months). Half of the patients are randomly assigned to receive Targretin capsules once daily in addition to the chemotherapy. The other half is randomized to receive a standard platinum-containing chemotherapy without Targretin capsules.

Eligibility Criteria:
Patients must have:

* Pathologic (histologic or cytologic) confirmation of NSCLC
* Stage IIIB with malignant pleural effusion or Stage IV disease
* At least one measurable or evaluable NSCLC lesion that has not been previously irradiated unless radiation therapy was more than three weeks prior to entry in the study and the lesion has been shown to have progressed subsequent to the radiation therapy
* ECOG performance status 0 or 1
* Adequate organ system function
* Fasting serum triglycerides that are within the age-adjusted normal range (or normalized with appropriate intervention such as antilipid therapy prior to the initiation of Targretin capsule therapy).

Patients must be able to complete at least four cycles of combination chemotherapy (i.e., approximately four months)

Patients must not have had:

* Brain metastasis
* Prior chemotherapy for NSCLC
* Prior platinum-based chemotherapy for any indication
An Innovative Treatment for Cervical Pre Cancer

The purpose of this study is to test two innovative devices, the CryoPen® and thermocoagulator, against gas-based cryotherapy to determine whether the novel devices produce equivalent or improved destruction of cervical tissue compared to gas-based cryotherapy. Tissue destruction with single freeze versus double freeze treatments with the CryoPen and gas-based cryotherapy will also be compared.

The primary objectives of the study are to test the hypothesis that the CryoPen® and thermocoagulator provide a non-inferior depth of cervical tissue necrosis compared with traditional CO2-based cryotherapy and to test single versus double freeze applications. The secondary objectives of the study are to determine if the CryoPen® or thermocoagulator achieves a depth of necrosis of 3.5 mm, the accepted depth required for eradicating 95% of cervical precancer, and to observe the relationship between depth of necrosis and variations in cervical anatomy.

Eligibility Criteria:
Inclusion Criteria:

* Between 25 and 65 years old.
* Scheduled for a hysterectomy for reasons other than cervical precancer or cancer
* Diagnosis of uterine, endometrial, ovarian or other cancer that does not jeopardize the tissue of the cervix is permitted
* Histological evaluation of the cervix does not interfere with the woman's current diagnosis
* Woman consents to participate after being informed about the study
* Normal Pap Smear or HPV test in the past 3 years

Exclusion Criteria:

* Pregnancy
* History of cervical surgery in past 5 years
* Presence of cervical lesion pre-invasive or invasive on the cervix \*
* Current Pelvic Inflammatory Disorder or severe acute cervicitis
* Cervix shape disfigured or hard to reach
A Drug-Drug Interaction Study of Diltiazem and MK-5684 in Healthy Adult Male Participants (MK-5684-011)

Researchers have designed a study medicine called MK-5684 as a new way to treat prostate cancer.

The purpose of this study is to learn what happens to MK-5684 in a person's body over time (a pharmacokinetic or PK study). Researchers will compare what happens to MK-5684 in the body when it is given with and without another medicine called diltiazem.


Eligibility Criteria:
Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

* Continuous non-smoker who has not used nicotine- and tobacco-containing products for at least 3 months prior to the first dosing based on participant self-reporting
* Body mass index (BMI) ≥18.0 and ≤32.0 kg/m\^2
* Able to swallow multiple tablets

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

* History or presence of any of the following:

  * Adrenal insufficiency
  * Hepatic or renal impairment
  * Clinically significant hypotension, cardiac arrhythmia, cardiac conduction abnormalities, or recurrent unexplained syncopal events
  * Second- or third-degree Atrioventricular (AV) heart block (except in participants with a functional artificial pacemaker)
  * Clinically significant sick sinus syndrome
  * Presence of any systemic fungal infection
  * Chronic infection
  * Glaucoma
  * Hypothyroidism
  * Stomach ulcer
  * Ocular herpes simplex
* Has a first-degree relative with multiple unexplained syncopal events, unexplained cardiac arrest, or sudden cardiac death, or has a known family history of an inherited arrhythmia syndrome (including Brugada syndrome)
* History of cancer (malignancy)
* Unable to refrain from or anticipants the use of: Unable to refrain from or anticipates the use of: Any drugs, including prescription and non-prescription medications, herbal remedies, or vitamin supplements beginning 14 days prior to the first dosing
Intranasal Cooling for Cluster Headache and Migraine

This study will be looking at the clinical efficacy of using a intranasal evaporative cooling device in providing relief of the symptoms of migraine and cluster headache. It will involve using a nasal catheter to spray a liquid coolant into the nasal cavity where it evaporates and removes heat from the tissue, thereby cooling the tissue and the blood vessels which supply blood to the brain. This cooling effect will cause the blood vessels to constrict and it is thought that this may provide symptomatic relief in both these forms of headache. 10 migraine patients and 5 cluster headache patients will be enrolled in the study and will receive 10 treatments each, for a maximum of 20 minutes at a time. They will be monitored during the treatment and for two hours afterwards to assess headache severity and side effects. There will be a further follow up 2 months after the last treatment to assess for longer term side effects from the treatment.


Eligibility Criteria:
Inclusion Criteria:

* \>18 Years old.
* Meets criteria for NICE guidelines diagnosis of cluster headache or chronic migraine
* Has not responded satisfactorily to migraine prophylaxis or standard analgesia
* Capable of giving informed consent

Exclusion Criteria:

* \< 18 years of age
* Subject has history of other severe co-morbid illness which would prevent full participation in the study
* Inability to insert the nasal cannulae
* Known temperature sensitive disorder such as reynauds, cryoglobulinaemia
* Known oxygen dependency to maintain SaO2 \>95%
Video Diversion During Fundoscopic Exam in Children

Fundoscopy is an important aspect of the neurological examination, but can be challenging in uncooperative children. This study explored whether viewing a video (selected by patient or caregiver) during eye examination improves the success, duration and ease of pediatric fundoscopy.

Hypothesis: Showing a short video clip during a fundoscopic exam will increase the probability of successfully visualizing the optic disk and reduce the amount of time needed to perform a fundoscopic exam in children between 1-8 years old.

The purpose of this study is to examine whether showing a video clip with sound of the patient's choice can improve the ease of fundoscopic exam as defined by improved success of visualizing the optic disk and the reduction in time needed to perform the exam. The investigators will also examine the physician's and caregiver's perception on whether the video was effective in improving the ease of the exam. The purpose of the video is to capture the visual attention of the patient thereby allowing the physician to swiftly perform the fundoscopic exam. The literature has suggested that young patients are most uncooperative, therefore the investigators will focus our study on younger patients 1-8 years old.

Eligibility Criteria:
Inclusion Criteria:

* 1-8 years old
* Capable of visualizing the video monitor
* Patient has 2 examinable eyes

Exclusion Criteria:

* Blind patient
* Patients \< 1 or \> 8 years old