cyrilzakka/clinical-trials huggingface dataset:
Comparison of Kinesio Taping and Myofascial Release in Cervicogenic Headache

Cervicogenic headache (CGH) is defined as a headache accompanied by neck pain, caused by a disorder in the cervical spine, bones, discs, or soft tissue elements. This study is designed as a prospective, case-control, hospital-based study. A total of 90 patients aged 18-65 years who have been suffering from CGH for at least three months and who present to the Physical Medicine and Rehabilitation Clinic of Meram State Hospital between January 2025 and January 2027 will be included in the study. Patients will be informed about the procedures, and informed consent will be obtained. The study will be conducted in accordance with the Declaration of Helsinki. A detailed medical history will be taken from all participants, and a comprehensive physical examination will be performed. Sociodemographic and clinical characteristics such as age, gender, height, weight, education level, employment status, and income level will be recorded. The 90 CGH patients will be divided into three groups.Group 1 (n=30) will receive myofascial release therapy + home exercise program for four weeks, three sessions per week, totaling 12 sessions. Group 2 (n=30) will receive Kinesio taping + home exercise program for four weeks, three sessions per week, totaling 12 sessions. Group 3 (n=30) will receive only a home exercise program for four weeks, three sessions per week, totaling 12 sessions. All evaluations will be conducted by the same researcher at three time points: before treatment (baseline), at the end of treatment (week 4), and one month after the completion of treatment (week 8).The aim of this prospective clinical study is to compare the effectiveness of Kinesio taping and myofascial release therapy in the treatment of cervicogenic headache.

This randomized, parallel-group clinical trial aims to compare the effectiveness of kinesio taping and myofascial release therapy in patients diagnosed with cervicogenic headache. The study is based on the hypothesis that both interventions can reduce pain intensity and functional disability, but their relative efficacy remains unclear. The trial is designed to provide clinical evidence to guide physiotherapeutic management of cervicogenic headache.

Eligibility Criteria:
Inclusion Criteria:Individuals aged 18-65 years Neck or headache persisting for at least 3 months

Meeting the diagnostic criteria for cervicogenic headache, including:

* Unilateral pain
* Reduced cervical range of motion
* Ipsilateral shoulder discomfort
* Ipsilateral arm discomfort
* Pain exacerbated by different neck movements and tenderness on palpation

Exclusion Criteria:

Migraine Cluster headache Cervical radiculopathy Entrapment neuropathy Myelopathy Rheumatoid arthritis Undergoing cervical spinal surgery Pregnancy Receiving physical therapy within the last 6 months History of major psychiatric disorders History of uncontrolled systemic diseases (cardiovascular, pulmonary, hepatic, renal, hematological, etc.) History of uncontrolled endocrine diseases (e.g., Diabetes Mellitus, hyperthyroidism, etc.)

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Bougie Versus Endotracheal Tube Alone on First-attempt Intubation Success in Prehospital Emergency Intubation (BETA Trial)

Emergency intubation is routinely performed in the prehospital setting. Airway management in the prehospital setting has substantial challenges, such as hostile environment or lack of technical support in case of first attempt intubation failure, and inherent risk of complications, such as hypoxemia, aspiration or oesophageal intubation. This risk is higher when several attempts are needed to succeed endotracheal intubation. Thus, a successful first attempt intubation is highly desirable to avoid adverse intubation-related events. Noteworthy, prehospital emergency intubation is associated with a lower rate of first attempt intubation success when compared to emergency intubation in the emergency department (ED). Research is needed to overcome the specific challenges of airway management in the prehospital setting, and to improve the safety and efficiency of prehospital emergency intubation. Literature reports that the use of assistive devices such as bougie may increase the rate of first-attempt intubation success in the ED. To date, no randomized trial has ever studied this device in the prehospital setting. Thus, the aim of the BETA trial is to compare first attempt intubation success facilitated by the bougie versus the endotracheal tube alone in the prehospital setting.


Eligibility Criteria:
Inclusion Criteria:

* Managed by a physician staffed mobile intensive care unit (MICU).
* With an indication of emergency prehospital endotracheal intubation.

Exclusion Criteria:

* Pregnant women
* Patients with a "not to be resuscitated" indication.
* Patients with predictors of difficult intubation (that can be collected in the prehospital setting, including previous history of face, neck, throat surgery or pathology, limited mandibular protrusion, cervical spine trauma, facial trauma, ear-nose-throat malignancy, head or neck burns, history of previous difficult airways) for whom the use of a bougie is indicated on first intubation attempt.
* Patients under guardianship, trusteeship or safeguard of justice and patients with no health insurance.
Functional Testing Underlying Coronary Revascularisation

The objective of this trial is to compare the clinical outcomes and cost-effectiveness of 2 therapeutic strategies, one based on coronary angiography guidance and the other based on coronary angiography with fractional flow reserve (FFR) in multivessel coronary artery disease patients.

The trial is a prospective, multicenter, French, randomized clinical trial including men and women ≥ 18 years presenting with significant multivessel disease defined by coronary angiography as coronary narrowing \> 50% diameter stenosis in at least 2 major epicardic vessels. The patients who give their informed consent will be randomly assigned to a therapeutic strategy based upon coronary angiography or angiography with FFR testing. In the FFR group, a significant coronary stenosis will be defined by a FFR ≤ 0.8. Based upon this multivessel evaluation (angiography or FFR), the investigator will choose the best therapeutic strategy to his discretion (medical optimal treatment, coronary stenting, coronary artery bypass graft surgery). The aim of revascularization procedures will be to obtain complete revascularization. In the FFR group, only stenosis with FFR≤0.8 will be treated.

The primary end point of the trial is a composite of major cardiovascular events including death from any cause, myocardial infarction, any hospitalization for coronary revascularization performed in addition to initial treatment and stroke at 1 year of follow-up.

Secondary end points will include adverse events, individual major cardiovascular events, stent thrombosis, bleeding events, occlusion of coronary artery bypass graft, patient's quality of life and cost-effectiveness and 30-day, 6 month, 2-year and 5-year outcomes.


Eligibility Criteria:
Inclusion Criteria:

* age \> 18
* referred to the cardiologist for one of the following medical condition :

  * ST segment elevation myocardial infarction evolving for more than 7 days after revascularization of culprit coronary artery or
  * no ST elevation acute coronary syndrome with or without troponin (T or I) elevation and medically stabilized for at least 12 hours or
  * stable angina (CCS I, II or III) or
  * chest pain diagnosis with suspicion of CAD or with ischemia certificated by non invasive tests.
  * patients with at least 2 vessel disease (≥50% stenosis on angiography) including the left anterior descending coronary artery or with single vessel disease on left main coronary artery
* Patient willing and able to provide informed, written consent
* Patient not under legal protection
* Patient benefiting from the French Health Insurance

Exclusion Criteria:

* Pregnancy, childbearing, absence of effective contraception
* Previous coronary bypass surgery
* Planned associated valvular surgery
* Life expectancy \< 2 years
Making Resident Well-Being a (Virtual) Reality

This study is a prospective cross-over trial examining the effect of virtual reality assisted meditation on resident reported well-being using validated scoring systems. The primary objective of this study is to evaluate the effectiveness of virtual reality guided meditation as a mechanism to improve plastic surgery resident well-being. The secondary objective is to assess resident likeliness to continue mindful meditation following completion of the study.

All plastic surgery residents participating will spend three months with access to virtual reality assisted meditation and three months without access to this technology. Assessment scores will be taken before and after the first three month period, and then again following the second three month period.

Eligibility Criteria:
Inclusion Criteria:

* Current resident of NYU Langone Plastic Surgery (Academic Year 2022-2023)
* Consent to participation in the study

Exclusion Criteria:

* Any plastic surgery resident involved in conducting the study
* Any non-plastic surgery resident during the academic year 2022-2023
* Any plastic surgery resident choosing not to participate in the study
Epidural Catheter Thread Between Two Different Vendors

The aim of the study is to assess if there is a difference in ability to thread the epidural catheter from two different epidural pain management kits vendors

The aim of the study is to assess if there is a difference in ability to thread the epidural catheter from two different pain management kits. In order to improve patient care, if there is a difference in the time to thread epidurals with one kit over the other, we would like to use the kit with decreased time to thread in the future.

Eligibility Criteria:
Inclusion Criteria: women in labor

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Exclusion Criteria:

* none
Propofolsleep - a Study on Cardiopulmonary and Pharyngeal Reactions While Drug Induced Sleep Endoscopy (DISE)

While Drug Induced Sleep Endoscopy (DISE) in patients with obstructive sleep apnea syndrome (OSAS) apnea and hypopnea occur. Because of the induced phases of apnea in a controlled setting it is possible to evaluate the related pathophysiology of apnea. We plan to correlate the Patient State Index (PSI) and other physiologic parameters with phases of apnea and hypopnea.

DISE is a standard method in diagnosis of OSAS and its specific localisation and severity. 20 patients with polysomnographic diagnosed OSAS will be enrolled in this prospective observational study. All patients would get a DISE because of the before mentioned reasons (localisation and severity) although they wouldn't participate in this study. They will get a 24-h-RR (blood pressure)-measurement, a transthoracic echocardiography, a peak-flow-test and routine lab examination including troponin and proBNP before the examination. Furthermore they have to fill out the Epworth Sleepiness Scale questionaire.

Before starting the DISE a standard-monitoring (Electrocardiography, pulse oximetry, non-invasive blood pressure, patient state index, near infrared spectroscopy, transcutaneous CO2 (carbon dioxide), invasive blood pressure) will be established. After applying the monitoring the DISE is started by target controlled infusion (Marsh Model) with a sighted goal-concentration of 3.0 µg/ml Propofol in 5 minutes. While the examination a stabile snoring-phase with apnoea/hypopnoea is needed. In this moment a video-endoscopy is started to quantify the level of obstruction. After DISE the sedation will end and the patients will be transported to the recovery room or postanesthesia care unit (PACU). For specific order of events a video recording of the DISE will be realized.

Eligibility Criteria:
Inclusion Criteria:

* informed written consent
* age of 18 years or older
* no participation in other prospective interventional studies
* OSAS with a polysomnographic shown AHI (apnea-hypopnea-index) of 15/h or more

Exclusion Criteria:

* no written informed consent
* allergies against study medication
* ASA (american society of anesthesiologists) class 4 or higher
* neurodegenerative CNS (central nerve system) or muscle diseases
* pregnant or breastfeeding patients
* 25 % or more central or mixed apneas in polysomnography
The Impact of Oral Vitamin C in Prevention for Post Operative Atrial Fibrillation (POAF) in Coronary Artery Bypass Surgery (CABG) Patients

Post operative atrial fibrillation (POAF) is one of the most common complications that takes place worldwide after coronary artery bypass surgeries (CABG). Many studies suggest using vitamin C as an additional treatment alongside standard therapies, such as statins and β-blockers, to reduce the risk of postoperative atrial fibrillation (POAF) in patients undergoing (CABG). Supplemental therapy with vitamin C may provide a more robust preventive effect against POAF compared to using statins and β-blockers due to its strong antioxidant effect. This implies that vitamin C can enhance the effectiveness of those medications used for POAF prevention by decreasing oxidative stress induced by the surgery.

There are conflicting data on whether or not vitamin C as an antioxidant has a protective effect against postoperative atrial fibrillation and has a significant role in shortening length of ICU and hospital stay . Even in those studies that show positive relationship of vitamin C in AF prevention, there is a diversity in the dosing regimen of vitamin C used among those previous studies.

To the best of our knowledge, most researches were conducted predominantly within a single geographic region, such as Iran, this raises the concerns about the potential bias and limits our ability to apply the findings to a broader global population.

Here, the investigators aimed to evaluate the effectiveness of vitamin C supplementation and to figure out which dose of vitamin C will prevent post-operative AF and decrease complications such as hospital stay, pneumonia and surgical site infection among older Egyptian adults.


Eligibility Criteria:
Inclusion criteria:

* Patients who underwent elective isolated on-pump coronary artery bypass surgery
* Age: 50 to 70 years
* No history of Coronary artery by pass surgery
* Taking maximum tolerated beta-blocker before and after surgery
* Normal left atrium and left ventricle dimensions

Exclusion Criteria:

* preoperative history of Atrial fibrilliation
* permanent pacemaker or significant bradycardia
* Hyperoxaluria or history of nephrolithiasis
* Left ventricular ejection fraction \< 40%
* Contraindications to beta-blocker or vitamin C.
* Patients with history of vitamin C consumption before surgery.
* Chronic kidney disease with creatinine \>2 mg/dl.
Quality of Life of Patients With Locally Advanced and Metastatic Prostate Cancer

The purpose of this study is to evaluate possible changes in quality of life related to health (HRQL) in locally advanced and metastatic prostate cancer patients, after one year of follow-up.


Eligibility Criteria:
Inclusion Criteria:

* Men ≥ 18 years old
* Symptomatic prostate cancer patients who present symptoms due to prostate cancer disease
* Capacity to comply with the protocol
* Patient with an expected survival \> 12 months

Exclusion Criteria:

* Patients who are also participating in any other clinical study
* Patient with other malignant diseases, apart from prostate cancer
Use of Fissure Sealants on Primary Molars

Sealants have been shown to be the most effective caries preventive measure in permanent dentition. Sealants of the primary molars soon after they erupt would reduce the total caries experience of the primary teeth of the children and could possibly also postpone the caries process in the permanent dentition.

The aim of this study is to measure the caries preventive effect of sealants in primary molars. The specific objectives are: 1) to compare the number of new caries experience teeth and surfaces among the intervention group of 4-years old pre-school children during the 1 year follow-up period, 2) to compare the preventive effect of sealants with fluoride varnish on the caries experience on the occlusal surfaces of the primary molars and on the total caries experience of all the primary and permanent teeth, 3) to test the feasibility of the sealant program in one kindergarten in Kuwait city.


Eligibility Criteria:
Inclusion Criteria:

* positive written informed consent received from parents

Exclusion Criteria:

* if caries lesions in primary molars are so extensive that restorative treatment is needed
Capsaicin-Evoked Pain in Patients With CRPS

To evaluate the effect of capsaicin in patients with Complex Regional Pain Syndrome.

Primary outcome parameters: Capsaicin-induced pain and inflammation.

Secondary outcome parameters: Peripheral sensory and autonomic function.

Eligibility Criteria:
Inclusion Criteria:

* Age: 18 or older.
* Pain in arm or hand \> 3 months.
* Diagnosed with CRPS acc. to diagnostic research criteria (Harder et al., 2005)
* Inclusion of healthy subjects: age-, gender-, and BMI-matched.

Exclusion Criteria:

* Other significant disease affecting the parameters measured, including cardiovascular disease.
* Treatment with anticholinergics, sympathomimetics and parasympathomimetics, and alpha- and beta-adrenergics.
The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer

Aberrant miRNA production has been linked to a wide range of human cancers and shown to play important roles in their genesis and growth. These miRNA can be detected in the blood and tumors of patients with cancer. The investigators hypothesize that the detection of certain miRNAs present in the blood/serum of patients with pancreatic cancer may be important to the early diagnosis of the disease. Furthermore, the investigators hypothesize that miRNA detection in PC patients will yield prognostic information and help predict the response to treatment.

Specific aims of the study include:

1. To obtain serum samples from patients with newly diagnosed pancreatic cancer at baseline before treatment and monthly throughout treatment.
2. To analyze the miRNA profiles present at each time point.
3. To determine miRNAs that may distinguish pancreatic patients from unaffected individuals. This could be developed into a diagnostic test.
4. To determine miRNAs whose levels correlate with treatment response, both in patients with and without elevations in the serum tumor marker CA 19-9.

Eligibility Criteria:
Inclusion Criteria:

* Have biopsy proven adenocarcinoma of the pancreas
* Have initially inoperable disease, classified as either locally advanced or metastatic disease

  * Recurrent disease after a Whipple procedure is allowed
  * Patients who are able to undergo resection after neoadjuvant therapy will continue to be followed after resection
* Have radiographically measurable disease
* Have an ECOG performance status of 2 or less
* Be willing to contribute the required information and specimens
* Provide written signed consent to participate

Exclusion Criteria:

* Having received prior anti-cancer treatments for metastatic pancreatic cancer
* Concurrently receiving systemic therapy for another cancer except androgen deprivation therapy for stable/controlled prostate cancer
* Presence of other active cancer except for: adequately treated local basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, superficial bladder cancer, asymptomatic prostate cancer without known metastatic disease and with no requirement for therapy or requiring only hormonal therapy and with normal prostate-specific antigen for \>1 year prior to start of trial. Other adequately treated Stage 1 or 2 cancer currently in complete remission, or any other cancer that has been in complete remission for \> 5 years is allowable
Robotic Assisted Transanal Total Mesorectal Excision Surgery for Rectal Cancer in Low Site

To investigates the feasibility, practicability, safety and subjective as well as functional outcome of Robotic transanal total mesentery excision for rectal cancer in low site.

Transanal total mesorectal excision (TaTME) may offer a better way to achieve radical resection and functional protection for lower rectal cancer, which have been regarded as challenging situations in rectal cancer surgery. However, the narrow angle and limited space of the operation restrict the wide spread of this technique. Da Vinci robotic system has achieved good results in rectal cancer surgery. Robotics may help to overcome technical difficulties in TaTME. The purpose of this study was to explore the availability of Da Vinci robotic-assisted transanal total mesorectal excision(R-TaTME) This study investigates the feasibility, practicability, safety and subjective as well as functional outcome of Robotic transanal total mesentery excision for rectal cancer in low site.

Eligibility Criteria:
Inclusion Criteria:

* adenocarcinoma of the rectum by biopsy
* the lower edge of the tumor from the anal margin less than 8cm according to MRI or rigid endoscopy
* tumor diameter less than 4cm
* baseline clinical stage I-III: cT1-3 N0-2 M0 (AJCC v7)
* tolerable to surgery
* be able to understand and willing to participate in this trial with signature

Exclusion Criteria:

* history of malignant colorectal neoplasia
* recent diagnosis with other malignancies
* patients requiring emergency surgery such as obstruction，perforation and bleeding
* tumor involving adjacent organs, anal sphincter, or levator ani muscle muti-focal colorectal cancer
* preoperative poor anal function, anal stenosis, anal injury, or fecal incontinence history of inflammatory bowel disease or familial adenomatous polyposis
* participating in other clinical trails
* History of pelvic radiation
* BMI \> 40
* Large uterine fibroids
* can not tolerate the surgery
* history of serious mental illness
* pregnancy or lactating women
* preoperative uncontrolled infection
* the researchers believe the patients should not enrolled in