cyrilzakka/clinical-trials huggingface dataset:
ImmunoPET Targeting Trophoblast Cell-surface Antigen 2 (Trop-2) in Solid Tumors

The objective of the study is to construct a noninvasive approach 68Ga-MY6349 PET/CT to detect the Trop-2 expression of tumor lesions in patients with solid tumors and to identify patients benefiting from Trop-2 targeting antibody-drug conjugate treatment.

As a new trophoblast cell-surface antigen 2 (Trop-2) targeting PET radiotracer, 68Ga-MY6349 is promising as an excellent imaging agent applicable to various cancers. In this research, subjects with various types of tumors underwent contemporaneous 68Ga-MY6349 and standard-of-care imaging (18F-FDG, 68Ga-PSMA, or 68Ga-DOTATATE PET/CT) either for an initial assessment or for recurrence detection. Tumor uptake was quantified by the maximum standard uptake value (SUVmax). The numbers of positive tumor lesions of standard-of-care imaging and 68Ga-MY6349 PET/CT were recorded by visual interpretation. The diagnostic accuracy of 68Ga-MY6349 was calculated and compared to standard-of-care imaging.

Eligibility Criteria:
Inclusion Criteria:

1. adult patients (aged 18 years or older);
2. patients with suspected or newly diagnosed or previously treated malignant tumors (supporting evidence may include MRI, CT, tumor markers and pathology report);
3. patients who had scheduled both standard-of-care imaging (18F-FDG, 68Ga-PSMA, or 68Ga-DOTATATE PET/CT) and 68Ga-MY6349 PET/CT scans;
4. patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee.

Exclusion Criteria:

1. patients with pregnancy;
2. the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.
Comparison of 18F FDG PET/CT TO PET MRI

The objective of this study is to gather image and associated data to of a pre-market PET/MRI scanner and to use the data for regulatory submission and future product development and marketing. Clinical data is required in order to test the MR attenuation correction of PET data. These aims can only be accomplished through a clinical study.


Eligibility Criteria:
Inclusion criteria

1. Subject must have a clinical indication for a PET/CT exam
2. Subject must be at least eighteen (18) years of age
3. Female subjects that are determined to be non-pregnant by a physician investigator or are demonstrated non-pregnant by negative urine pregnancy test administered within the 24 hour period before PET/CT imaging
4. Subject must be able to hear and understand instructions without assistive devices
5. Subject must provide written informed consent
6. Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements
7. Subject is able to remain still for duration of imaging procedure (approximately 60 minutes total for PET/MRI); and
8. Subject must be able to participate in a PET/MR imaging session within 1 hour of concluding their PET/CT exam.

Exclusion criteria

1. Subjects who have any axial diameter larger than 55 cm
2. Subjects with a weight greater than 499 lbs
3. Subjects that have metallic/conductive or electrically/magnetically active implants without MR Safe or MR Conditional labeling, with the exception of dental devices/fillings, surgical clips, and surgical staples determined to be safe for MRI scanning by a physician investigator
4. Subjects that have implants with MR Unsafe labeling;
5. Subjects that have implants labeled as MR Conditional by the manufacturer for which the allowable conditions are not expected to be achieved by the MR/PET environment or scan protocol;
6. Subjects who have a contraindication to MRI per the screening policy of the participating site.
Cohort Study in Type 2 Diabetes in China

This study is designed to assess the incidence of cardiovascular events occurred within an 12 month follow up period in type 2 diabetic patients with either high risk of cardiovascular disease (CVD) or history of coronary artery disease (CAD) or stroke.

The number of diabetes patients around the world has increased from 30 million in 1985 to the current 180 million, and is expected to grow to 366 million in 2025, with 75 percent occurring in developing countries such as India and China. In China, economic prosperity and changes in diet and lifestyles have resulted in steep increase in prevalence of overweight, obesity, and diabetes. Type 2 diabetes mellitus is associated with an increased risk for both micro-and macrovascular complications, and cardiovascular diseases (CVD) are the most common causes of death in these patients. Preventing the onset or the worsening of the cardiovascular diseases is thus one of the most important goals in managing type II diabetes. This study is designed to better understand the incidence of cardiovascular events under current patterns of treatment in type 2 diabetic patients with either 3 or more risk factors for cardiovascular disease such as older age, hypertension, dyslipidemia, etc, or existing or prior history of coronary artery disease and stroke. Approximately 1000 patients from major hospitals across several regions of China will be recruited for this study.

Eligibility Criteria:
Inclusion Criteria:

* Patients who are 40 years of age or older
* Patients with confirmed diagnosis of type II diabetes
* Patients with 3 or more CVD risk factors or with confirmed/history of CAD or history of ischemic stroke
* Patients who have lab data within 30 days of baseline visit
* Patients who are willing to return for all follow up visits

Exclusion Criteria:

* Patients who are not willing or not able to return to the same hospital within 12 months after enrollment
* Patients who have life threatening or terminal disease, or are physically unable to make follow up visits every 6 months after enrollment
* Patients have severe heart failure (New York Heart Association \[NYHA\] Class 3-4)
* Patients with severe renal deficiency (creatinine clearance less than 30 ml/min)
* Patients who are not willing to sign informed consent form
Staging of Superficial EAC Using VLE

This study is being done to see if the NvisionVLE Imaging System can accurately determine the diagnostic performance of staging of T1 esophageal adenocarcinoma.

Volumetric laser endomicroscopy (VLE) is an imaging platform that uses infrared light to generate cross-sectional views of the human esophagus with microscopic resolution. VLE has been used to detect dysplasia associated with Barrett's esophagus (BE) but its use in cancer staging has not been previously explored. The investigators propose that VLE can accurately and comprehensively stage T1 EAC.

VLE scans will be analyzed using an automated computer algorithm to measure degree of signal attenuation over areas demarcated for endoscopic mucosal resection (EMR). The signal attenuation cut-off established will be used to classify cancers as superficial versus deep. EMR specimens will be reviewed histopathologically for grade of tumor differentiation, depth of invasion, and presence or absence of lymphovascular invasion. Depth of tumor invasion will be measured and used to classify cancers as superficial versus deep.

Eligibility Criteria:
Inclusion Criteria:

* Patient over the age of 18
* Patient undergoing an upper endoscopy with prior-biopsy confirmed Barrett's Esophagus.
* Ability to provide written, informed consent
* No significant esophagitis (LA grade \<B, C, and D)

Exclusion Criteria:

* Patients who have achieved complete remission of intestinal metaplasia (CR-IM)
* Patients without visible Barrett's Esophagus at the time of study esophagogastroduodenoscopy (EGD)
* Patients for whom use of the NvisionVLE device would be in conflict with the instruction for use.
* Prior esophageal or gastric surgical resection
* Significant esophageal stricture requiring dilatation
* Patients who require anticoagulation for who biopsy would be contraindicated
* Patients who are known to be pregnant
Epstein-Barr Virus Status in Diffuse Large B Cell Lymphoma

The investigators analyzed clinical outcome in DLBCL patients according to age group to define the impact of EBV status on the clinical outcome.

Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) has been recognized as a new provisional entity in the 2008 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissue. This lymphoma is defined as EBV+ clonal B-cell proliferation in immunocompetent adults older than 50 years. To denote patient age in definition of this disease, age cutoff was defined as older than 50 years. However, this cutoff is clearly arbitrary without any scientific background. the knowledge on EBV+DLBCL in young adult is very scanty. This EBV+DLBCL in young adult can be the same disease entity or it can be a distinct disease form EBV+DLBCL of elderly.

Eligibility Criteria:
Inclusion Criteria:

* Pathologically confirmed de novo DLBCL, according to the World Health Organization (WHO) classification:

  * registered in Samsung Medical Center (SMC) Lymphoma Cohort Study I/II (ClinicalTrials.gov Identifier: NCT00822731, NCT01877109) or identified from Asan Medical Center (AMC) medical database:
  * adequate amount and quality of paraffin-embedded biopsy specimen or unstained slides for EBV-encoded RNA (EBER) in situ hybridization.

Exclusion Criteria:

* Patients with unknown EBV status, primary central nervous system (CNS) lymphoma, post-transplant lymphoproliferative disorders (PTLDs), and HIV-positive DLBCL were excluded in the study.
P Wave and QT Dispersion in Psoriasis

Background:

Several reports have demonstrated an association between psoriasis and cardiovascular diseases. P wave dispersion (PWD) is the most important electrocardiographic (ECG) markers used to evaluate the risk of atrial arrhythmias. QT dispersion (QTD) can be used to assess homogeneity of cardiac repolarization and may be a risk for ventricular arrhythmias.

Aim: To search PWD and QTD in patients with psoriasis. Methods: Ninety-four outpatient psoriasis patients and 51 healthy people were evaluated by physical examination, 12-lead ECG and transthoracic echocardiography. Severity of the psoriasis was evaluated by psoriasis Area and Severity Index (PASI).

Ninety-four outpatient psoriasis patients and 51 healthy people were included in the study. Patients having systemic hypertension, diabetes mellitus, history of ischemic heart disease, significant valvular heart disease, chronic obstructive pulmonary disease, hypo or hyper-thyroidism, renal failure or any associated systemic disease were excluded. Diagnosis of psoriasis was confirmed by dermatological examination and/or punch biopsy. Severity of the psoriasis was evaluated by psoriasis area and severity index (PASI). Patients were evaluated by physical examination, 12-lead electrocardiography and transthoracic echocardiography.

Eligibility Criteria:
Patients having systemic hypertension, diabetes mellitus, history of ischemic heart disease, significant valvular heart disease, chronic obstructive pulmonary disease, hypo or hyper-thyroidism, renal failure or any associated systemic disease were excluded.
Comparison of Human Embryo Development Using Sequential and Single Media With Time-lapse Imaging

The purpose of this study is to compare human embryo in vitro development in sequential and single-step culture medium using time-lapse imaging.

Objective: To study whether a culture medium that allows undisturbed culture supports human embryo development to the blastocyst stage equivalently to a well-established sequential media.

Design: Randomized, double-blinded sibling trial. Setting: Independent in vitro fertilization (IVF) clinics. Patient(s): One hundred twenty-eight patients, with 1,356 zygotes randomized into two study arms.

Intervention(s): Embryos from each patient were randomly allocated into two study arms to compare embryo development on a time-lapse system using a single-step medium or sequential media.

Eligibility Criteria:
Inclusion Criteria:

* 6 or more normal embryos following egg retrieval and fertilization.
* Female patients aged 21-40 years or 21-55 years who are using an egg donor.
* Patients using fresh or frozen ejaculated sperm

Exclusion Criteria:

* Previous history of cancer
* Day 3 embryo transfer
Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa

Decreased bone strength is a serious medical problem present in many women with Anorexia Nervosa, or disordered eating. Women with weaker bones are more likely to suffer broken bones than women with normal bone strength.

We are investigating whether a hormone that is naturally produced by the human body, called growth hormone, can help strengthen the bones of women with this type of disordered eating.

* Twelve week study
* Eight visits, six of which can be conducted at your home physician's office
* Two bone density scans
* Hormonal and nutritional evaluations

Eligibility Criteria:
Inclusion Criteria:

* women between 14 to 45 years with anorexia nervosa

Exclusion Criteria:

* pregnancy
* previous history of malignancy.
* oral contraceptive pills or other hormones within last 8 - 12 weeks
* medications known to affect bone within last 12 weeks
* fracture within last 6 months
Construction and Evaluation of a Stoma Patient Care Network

Establish a uniform care network for stoma patients in Shaanxi Province and evaluate its effectiveness, so that stoma patients can get the same quality of stoma care outside the hospital.

This project plans to take the First Affiliated Hospital of Xi'an Jiaotong University as the lead hospital to establish a uniform care network for stoma patients in Shaanxi Province. This network includes the management system of stoma nursing and the management organization of stoma patients in Shaanxi Province. It formulates the whole quality standard of stoma nursing in Shaanxi Province, carries out "standard training" for the stoma specialty nurses in the group, and carries out on-site inspection in various hospitals from time to time, establishes the feedback mechanism and standardizes the stoma nursing process. The contact card of stoma therapists was made and distributed to patients with stoma, so that patients can easily get the information of stoma therapists in the nearest hospital and receive professional and convenient care. WeChat group of specialized stoma nurses was established to provide remote guidance for difficult cases, share new stoma ideas and knowledge, and facilitate communication among stoma nurses in the group. The leading hospital holds training courses on knowledge and progress of stomatology every year, competitions on knowledge and skills, and dispatches therapists to provide work guidance, so as to share new knowledge, skills and scientific research abilities. At the same time, the efficacy of the network was evaluated by investigating the complication rate, self-care ability, quality of life, medical costs of stoma patients,as well as the specialized nursing skills and professional development of nurses.

Eligibility Criteria:
Inclusion Criteria:

* patients aged ≥18 years old;
* patients undergoing enterostomy;
* patients with primary school and above education level;
* patients with clear consciousness, reading and verbal expression ability;
* patients could reexamine regularly;
* patients informed consent and voluntary participation in the study.

Exclusion Criteria:

* patients with organ dysfunction who have difficulty in self-care;
* patients with mental illness, consciousness disorder or communication disorder.
The Impact of Physical Exercise on Navigation Performance in Soldier

20 healthy man, 10 in trial group and 10 in control group (randomly divided) will participate in the experiment on order to evaluate if improvement in physical fitness influences spatial learning in humans.

subjects in both groups will perform 4 sets of VO2max test and spatial orientation test with a month between them (total 3 month).

in addition, subjects in trial group will follow a training program throughout the trial (running on treadmill 3 times a week), suited according to their result in the first VO2max test.

in each set VO2max test will be perform before spatial orientation test , in order to evaluated the subject's aerobic fitness. the spatial orientation test is composed of 5 following days in which the subject has 3 attempts to arrive to a destination in xbox one controller using a virtual glasses (Oculus Rift DK2). each attempt duration is 2 min.

Eligibility Criteria:
Inclusion Criteria:

* civilian healthy man, aged 18-30
* without any neurological or psychiatric disorder
* not wearing eyeglasses

Exclusion Criteria:

* athletes or trained man (for both groups)
Experiences of Participating in Return to Work Group Programmes

To explore the experiences of individuals with musculoskeletal disorders (MSDs) who have participated in return-to-work group programmes (RTW-GPs) and see how the programmes could strengthen their work ability.

For a representative sampling of experiences, participants who had participated in various groups over time in outpatient and inpatient groups in the RTW-GP were invited to enrol in the study. Other inclusion criteria were age between 25 and 65 years, different musculoskeletal diagnosis and that they should come from the rural district/city of residence.

The participants received requests by letter to participate in the focus group interview six months after the final group intervention, the same time as they were invited to a follow-up visit. Only a few men had participated in the RTW-GPs and none of them wanted to take part in the study.

All participants were given written and oral information about the study, the use of recording and transcribing devices, and their right to withdraw from the study at any time. The interviews were carried out after the participants gave written, informed consent.

Three focus group interviews were conducted: one with six participants, and two with five. One participant who could not participate in the focus group interview participated at an individual interview with the same questions as in the focus groups. The individual interview was conducted first and served as a test for the questions in the interview guide.

Interventions The participants of this study had participated in one of three different RTW-GPs. These programmes are designed to enable participants to proactively take action in their daily lives and in collaboration with employers achieve the best possible working conditions. All the group sessions are based on cognitive theory where attention, awareness and reflection on one's own work and life situation is important. Motivation is instilled by helping participants recognise opportunities for change. Participants set work-related goals and receive individual feedback from multidisciplinary personnel in addition to various group-based sessions with teaching, activities and exercises. The participants are referred to the programme by a rheumatologist or a member of the hospital's multidisciplinary team as soon as possible after starting sick-leave.

Eligibility Criteria:
Inclusion Criteria:

* Participating RTW-GP
* Musculoskeletal diagnoses
* From the rural district/city of residence
* Speaking Norwegian
The Effects of Kinesio Taping on Pain, Range of Motion, and Functional Performance in People With Knee Osteoarthritis

The goal of this clinical trial is to evaluate the effectiveness of Kinesio Taping in individuals with knee osteoarthritis (KOA). KOA is a common condition that can lead to pain, stiffness, and decreased mobility. The main questions it aims to answer are:

* Does Kinesio Taping reduce pain in individuals with KOA?
* Can Kinesio Taping improve the range of motion and functional performance in those suffering from KOA?

Participants will be asked to:

Attend assessment sessions at the outpatient Physical Therapy clinic at Taibah University.

Undergo Kinesio Taping three times over 12 days. Complete specific physical tests and questionnaires before and after the intervention period to measure their pain and mobility.

Researchers will compare the group that receives Kinesio Taping with the group that receives sham (placebo) taping to see if there are significant differences in pain reduction and improvements in movement and daily function.

Study Overview

This clinical trial explores Kinesio Taping's (KT) effect on knee osteoarthritis (KOA) in adults. It delves into whether KT can alleviate pain and improve joint movement and daily functioning. The research, hosted at Taibah University's Physical Therapy clinic, focuses on practical benefits for patients with KOA, a condition that leads to significant discomfort and mobility issues, especially prevalent in Saudi Arabia.

Study Design

In a randomized and single-blinded approach, participants are divided into two groups. One group receives actual Kinesio taping, while the other undergoes a sham procedure, with neither group aware of their specific treatment type to ensure unbiased results.

Intervention Procedures

Participants undergo three Kinesio taping sessions spread over 12 days. The taping technique is performed according to prescribed methods that target the quadriceps femoris muscle, believed to influence pain perception and joint function positively.

The study employs a before-and-after intervention assessment model. Initial data collection includes patients' demographic details and baseline characteristics related to their health status and disease severity. Following the intervention, the same measures are reassessed to evaluate any changes attributed to the KT.

Eligibility Criteria:
Inclusion Criteria:

* Patients clinically and radiologically diagnosed with unilateral or bilateral knee OA.
* Independent gait
* Any grade on the Kellgren-Lawrence scale

Exclusion Criteria:

* Previous fractures of the femur and/or tibia.
* Comorbidities such as neurological diseases, malnutrition, and other inflammatory and/or infectious diseases.
* Radicular pain in the lower limbs or diabetic neuritis.
* Prior physiotherapy in the past month.