cyrilzakka/clinical-trials huggingface dataset:
CT Temporal Bone Anatomical Variations

This study aimed to identify the prevalence of normal variations of temporal bone anatomy on high-resolution CT imaging and discuss their clinical importance

The temporal bone has a difficult anatomical structure for otologists and radiologists.In addition to its anatomical complexity, variations in the three-dimensional relationships of structures within the temporal bone need additional attention. The assessment of these relationships is of primary importance in diagnosis, treatment planning, and preoperative management. High-resolution computed tomography (CT) helps locate the anatomical structures within the temporal bone. Preoperative knowledge of the courses of vascular structures within and neighboring the temporal bone is of primary importance. If not detected preoperatively, variations in the localizations of the vascular structures may lead to disastrous consequences during surgery. The surgically important positions of the vascular structures that are generally accepted as normal variants are, High-resolution CT has made it possible for clinicians to study middle- and inner-ear pathology before undertaking surgery. This is particularly useful when the disease has altered the anatomy, resulting in complications such as a lateral canal fistula and facial canal or tegmen erosion there have been several studies reporting the value of high-resolution CT for investigations of cholesteatoma, temporal bone tumors, and congenital anomalies studies on the prevalence of normal anatomical variations of the temporal bone as the use of high-resolution CT imaging for temporal bone investigations is now widespread, it is necessary for the investigating otologist to be aware of common anatomical variations and their clinical implications

Eligibility Criteria:
Inclusion Criteria:

- All adult patients presented with any middle ear pathology indicated for temporal bone radiological evaluation and were willing to participate in the study

Exclusion Criteria:

- 1- patients with temporal bone neoplastic disorders distorting normal temporal bone anatomy.

2- Extensive trauma to the temporal bone 3- Patients with congenital anomalies and craniofacial disproportions 4- Patients with mastoid surgery 5- Patients in whom radiological evaluation is contraindicated
POWERSforID: A Telehealth Weight Management System for Adults With Intellectual Disability

POWERSforID is a 24 week randomized control trial designed to assess the feasibility of a telehealth and coaching intervention for improving health outcomes of adults with intellectual disability. Recruitment is conducted through a disability health clinic located in Colorado Springs, CO.

POWERS (Personalized Online Weight and Exercise Response System) platform is a novel, multifocal-centered tailored intervention utilizing an innovative online tool designed to facilitate improvements in physical activity and nutritional behaviors. Aim 1 of this protocol is to customize the POWERS platform, demonstrated effective in previous research, for adults with intellectual disability (ID) and their caregivers to be referred to as POWERSforID. The POWERSforID intervention is designed to achieve weight loss and improve specific health markers while respecting and supporting the needs of the participants with ID as well as their caregivers. Aim 2 of the project is to conduct a pilot study to assess the usability and feasibility of the POWERSforID system and intervention with 5 adults with ID and their caregiver and improve the system based on pilot data. Aim 3 of the protocol is to conduct a randomized controlled trial (RCT) to examine the effect of POWERSforID on educating and coaching caregivers about nutrition and exercise and thus improving health status and reducing body weight in obese adults with ID. The investigators hypothesize that the obese participants in the intervention group (POWERSforID) will evidence significantly greater weight loss and improved health status (i.e. lower waist circumference, blood pressure, decreased body fat percentage, and improved blood lipids) compared to a control group. The investigators also hypothesize that both adults with ID and their caregivers will demonstrate improved knowledge, attitudes, and self-efficacy related to diet and exercise.

Eligibility Criteria:
Inclusion Criteria:

* Participants with intellectual disability (ID) who meet the following inclusion criteria are eligible to participate in the study:

  * Body Mass Index \> or equal to 30 kg/m2;
  * Diagnosis of mild or moderate ID;
  * 25 to 50 years of age;
  * Medical provider approval to participate in a weight loss program;
  * Has a caregiver who agrees to participate in the study and provides services 4 days a week or more to the adult with ID;
  * Has access to a computer with internet throughout the week.

Exclusion Criteria:

* Currently on a weight loss program;
* Medical conditions that prevent participation as noted by the medical provider or legal guardian including heart and/or renal disease;
* Behavioral issues determined by the DDHC Behavioral Health staff;
* Unable to walk or exercise due to a mobility impairment or medical condition;
* Judged to have insufficient capacity to consent or assent as assessed using the "Supplemental Consent Document".
Influencing Factors and Trigger Mechanism of Relapse in Expectant Fathers Who Quit Smoking

The purpose of this study is to describe the relapse rate and characteristics of expectant fathers who quit smoking during their wives' pregnancy, to explore the influencing factors and triggering mechanisms,and describe their experience.

Participants will be invited to recall their smoking status and experience during their wife's pregnancy (all participants and required to complete the questionnaire, and some of them will be invited to participate in semi-structured interviews).

In the quantitative study,participants need to finish the questionnaire,which includes the demographic information sheet, characteristics of smoking sheet, history of smoking cessation sheet, smoking hazard questionnaire, motivation to quit smoking sheet, ability to quit smoking sheet, alcohol consumption, exercise.

In the qualitative study,participants need to participate in semi-structured interview.The interview begins with "Have you tried smoking cessation before? Why? What is the result", and explores in-depth analysis based on the participants' answers.

Eligibility Criteria:
Inclusion Criteria:

* (1) All participants should be aged 18 or above;
* (2) The newborn of the participant is alive, and the number of days of birth is ≤28 days;
* (3) All participants should have actively quit smoking during his wife's pregnancy, and maintained it for at least 24 hours;
* (4) All participants should be smoking at least 1 cigarette per day on average for at least 1 month in the past 1 year;
* (5) All participants should be able to communicate in Mandarin (including reading Chinese).

Exclusion Criteria:

* All participants who meet the above criteria but are currently involved in other smoking cessation programs or the pilot study and/or mentally or physically unfit for communication will be excluded.
A Comparative Study of Incentive Spirometry and Positive Expiratory Pressure in Chest Trauma

Chest trauma (CT) patients with 3 or more ribs fractures with or without pleuropulmonary injury are an indicator of severity. Chest physiotherapy (CP) and analgesia is the first line treatment in these patients.

The aim study is to evaluate the effect of positive expiratory pressure (PEP) breathing compared to the incentive spirometry in terms of pain control in the recent phase of CT.

After acceptance to participate in the study, patients will be computerized randomized into 2 groups:

* PEP group: positive expiratory pressure (PEP) breathing.
* INS group: inspiratory incentive spirometry breathing. The period between day 0 and 20 days post-trauma is considered an immediate phase of TT.

Once admitted, an initial evaluation by the doctor will be performed, and pleuro-pulmonary complications, the presence of respiratory failure, and pain control will be evaluated. The CP will perform a clinical, pain control, secretion and a dynamic costal examination. The medical treatment of pain control will begin, and the treatment of CP will begin, where it will be randomized in 2 groups: 1- PEP group: positive expiratory pressure (PEP) breathing the help of a PEP bottle device. 2- INS group: inspiratory incentive spirometry device (Coach®). Will be daily FR sessions, on weekdays. Upon admission, hospital discharge and post-discharge, radiological checks (simple radiography) will be performed and forced vital capacity will be measured with forced spirometry.

Eligibility Criteria:
Inclusion Criteria:

* Chest trauma of 3 or more rib fractures with or without hemopneumothorax
* Signed informed consent.

Exclusion Criteria:

* Non-collaborating patients.
* Failure to submit a duly completed follow-up sheet for carrying out a minimum daily guideline (3 times a day) for CP treatment.
* Presence of respiratory failure at admission: PaO2 \<60mmHg and / or PaCO2\> 50mmHg.
* Medical indication for invasive or non-invasive ventilatory support.
* Presence of undrained pneumothorax.
* Complications that limit early mobility.
A Study of BMS-582949 in Patients With Moderate to Severe Plaque Psoriasis

The purpose of this clinical research study is to learn if BMS-582949 alone is an effective treatment for moderate to severe psoriasis. The safety of the drug and the effectiveness of each dose will also be studied.


Eligibility Criteria:
Inclusion Criteria:

* Males and Females (not nursing or not pregnant)
* 18-75 years of age
* Diagnosis of moderate to severe psoriasis for at least six months at the time of screening
* Subjects will require wash-out of certain therapies for the treatment of psoriasis but will be allowed to continue on certain topical therapies
Early Initiation of Post Sternotomy CArdiac Rehabilitation

The main objective of this trial is to investigate the effects of starting exercise rehabilitation earlier than current practice after coronary artery bypass graft(CABG) or Aortic/Mitral valve replacement (VR) surgery.

The trial will compare health improvements after cardiac rehabilitation, (CR) between participants randomly allocated to one of two groups: an early CR group starting exercise after 2 weeks, and a usual care group starting at 6 weeks. It will also collect information on the financial cost of earlier CR to both the health service and the patients.

All primary and secondary outcome measures will be taken at baseline (1 week) and repeated at the start and end of 8 weeks exercise rehabilitation program (2 and 10 weeks from baseline for the early group, 6 and 14 weeks in the usual care group respectively) and at 12 months follow-up.

Eligibility Criteria:
Inclusion Criteria:

* Coronary artery bypass graft, and mitral/aortic valve replacement patients recovering from sternotomy procedure eligible for cardiac rehabilitation
* Able to provide written informed consent
* Male or female 18 years of age or greater

Exclusion Criteria:

* Patients with any of the following:

  * Serious cardiac arrhythmias
  * Current neurological disorders or previous Cerebral Vascular Accident with residual neurological deficit significant enough to limit exercise
  * Enrolled on another clinical trial that involved exercise
  * Unable to enroll for duration of study
* Patients who are unable to provide written consent.
* Patients under the age of 18 or over the age of 90.
Turkish Validity and Reliability of Oral Health Impact on Daily Life Questionnaire

This study aimed to test Turkish validity and reliability of the Oral Health Impact on Daily Life Questionnaire (OHIDL) in adult endodontic patients.The questionnaire was translated and adapted into Turkish. Then, it was applied to two hundred twenty-two participants aged 18 years.

This study aimed to test Turkish validity and reliability of the Oral Health Impact on Daily Life Questionnaire (OHIDL) in adult endodontic patients.

The questionnaire was translated and adapted into Turkish. Two hundred twenty-two participants aged 18 years and over without systemic disease were included. The reliability was examined by internal consistency and test-retest reliability. The construct and criterion validity were examined by evaluating the correlation of each question with the domains, the correlation of the domains with the global questions, and the correlation of Turkish-OHIDL with the Turkish version of the Oral Health Impact Scale (OHIP-14-TR). Statistical analysis was performed with SPSS 21.0 (IBM Corp, Armonk, NY, USA). P \<0.05 was considered statistically significant.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 years and older who applied to the Department of Endodontics

Exclusion Criteria:

* Patients who did not speak Turkish,
* Patients having cognitive impairment,
* Patients having communication difficulties
Double Blind Controlled Trial of an Extensively Hydrolyzed Formula With a Probiotic vs. an Extensively Hydrolyzed Formula Without a Probiotic

The purpose of this study is to confirm the hypoallergenicity of an extensively hydrolyzed formula with an added probiotic in children with documented milk allergy.


Eligibility Criteria:
Inclusion Criteria:

* ≤14 years of age
* Essentially asymptomatic for a minimum of 7 days pre-challenge.
* Successful previous consumption of Extensively Hydrolyzed Formula within 1 week of study enrollment
* Medically documented allergy to cow's milk

Exclusion Criteria:

* Presence of underlying systemic disease or other illness
* Used Beta-blockers within 12-24 hours of challenges
* Use of short-acting antihistamines within 3 days
* Use of medium-acting antihistamines within 7 days
* Use of long-acting antihistamines within 6 weeks
* Use of oral steroid medication within 3 weeks
Effect of High-carbohydrate or High-monounsaturated Fat on Blood Pressure: Meta-analysis of Randomized Clinical Trials

High saturated fat acids diets are associated with elevated blood pressure which is associated with cardiovascular morbidity and mortality. For this reason, a change of diet is recommended to manage blood pressure and prevent cardiovascular complications. To achieve this nutritional goal, a high-carbohydrate diet or high-monounsaturated fat diet can be advised in the replacement of a saturated fat diet.

Previous meta-analysis of Garg (1998) cited randomized articles with inconsistent blood pressure lowering after consumption of a high-monounsaturated-fat diet compared with a high-carbohydrate diet only in type 2 diabetes patients. Moreover, another meta-analysis of Shah et al. (2007) showed slightly high blood pressure on diets rich in carbohydrates than diets rich in cis-monounsaturated fat after randomized and nonrandomized articles.

For this reason, a new meta-analysis of a randomized clinical trial will be performed to clarify the effects of high-carbohydrate or high-monounsaturated fat diets on blood pressure. Results from this meta-analysis will help health professionals take important decisions on patient diet and minimize cardiovascular morbidity and mortality.


Eligibility Criteria:
Inclusion Criteria:

* Randomized controlled trials
* Parallel or Crossover Design
* Duration: at least 3 weeks
* Isocaloric diet
Impact of IIT-SIT on Dengue Clusters

This randomized controlled trial aims to evaluate the efficacy of Wolbachia-infected male mosquitoes combined with sterile insect technique (IIT-SIT) to mitigate active dengue transmission in Singapore.

Aedes-borne diseases are expected to increase in geographical coverage and intensity due to climate change and rapid urbanization. It has been demonstrated that Wolbachia-mediated incompatible insect technique coupled with sterile insect technique (IIT-SIT) is highly effective in suppressing Aedes populations and subsequently reducing dengue risk. However, the efficacy of the tool in mitigating ongoing transmission is unknown.

The researchers outline a randomized controlled trial to be conducted in high-rise public housing estates in Singapore to assess the efficacy of IIT-SIT to mitigate active dengue transmission. Specifically, the study will determine whether the release of male Wolbachia-infected Aedes aegypti mosquitoes can curtail the growth of dengue clusters, defined operationally by the Singapore National Environment Agency (NEA) as two or more reported dengue cases within a 150-meter radius and with illness onset dates within 14 days of each other. This study will randomize eligible clusters into intervention/control arms in real-time. Clusters assigned to the intervention arm will receive IIT-SIT treatment until cluster extinction (i.e. when no further cases are linked to the cluster). This trial closely mimics how IIT-SIT could be used as an additional tool for outbreak management, by treating areas with active dengue transmission in real-time. Conventional vector control measures will be carried out as per NEA's usual outbreak management practices in both intervention and control clusters. The intervention efficacy will be estimated through two primary endpoints: (1) probability of cluster extinction, as estimated from the time-to-cluster extinction among intervention versus control clusters; and (2) final size of the dengue cluster, as estimated by the difference in the final number of dengue cases in intervention versus control clusters.

This study will provide evidence from a randomized controlled trial for the efficacy of IIT-SIT in curbing ongoing transmission and provide an epidemiological basis for integrating IIT-SIT into the existing arsenal of outbreak management tools. The trial will assess the technology's feasibility for operationalization, and identify difficulties in implementation prior to larger-scale use for outbreak control.

Eligibility Criteria:
Eligible dengue clusters will be limited to public housing estates and with at least 10 dengue cases comprising that dengue cluster before allocation into intervention or control arms. The selected clusters will be in areas with relatively high sector-level GAI of at least 0.2 at the time of the 10th reported case. Additionally, the first 10 cases must be reported within 30 days of the first case. Additionally, clusters must be in areas which have never experienced Wolbachia-Aedes releases and at least 700 m away from existing Wolbachia-Aedes release areas.
PDGeneration: Mapping the Future of Parkinson's Disease

To assess the feasibility, impact, and participant satisfaction of offering Clinical Laboratory Improvement Amendments (CLIA) certified genetic testing as part of clinical care for People with Parkinson's disease (PWP).

The purpose of this study is to evaluate how offering Clinical Laboratory Improvement Amendments (CLIA) certified genetic testing for Parkinson's Disease (PD) genes to people with Parkinson's Disease impacts clinical care and potential enrollment in clinical trials. This multi-center study will assess the impact and satisfaction of the mode of genetic counseling by comparing counseling conducted by a clinician versus centralized genetic counseling conducted through Indiana University. The study will also assess knowledge gained by administering a knowledge survey pre- and post-genetic testing. All genetic test results will be returned to participants through a genetic counseling visit.

Eligibility Criteria:
Inclusion Criteria:

1. Meet Movement Disorder Society (MDS) Clinical Diagnostic Criteria for Parkinson's Disease: probable diagnosis.
2. Willingness to undergo genetic testing, and choose to be informed of genetic testing results for Glucosylceramidase Beta (GBA), LRRK2 and 5 additional PD related genes (SNCA, VPS35, PRKN, PINK-1, PARK7).
3. Capacity to give full informed consent in writing, and have read and signed the informed consent forms (ICFs) based on clinician's determination.
4. Able to perform study activities (including completion of either online, in-person or paper surveys).
5. Individuals must speak and understand the language of the informed consent.

Exclusion Criteria:

1. Diagnosis of an atypical parkinsonian disorder (i.e., multiple system atrophy, progressive supranuclear palsy, dementia with Lewy bodies, corticobasal syndrome), including that due to medications, metabolic disorders, encephalitis, cerebrovascular disease, or normal pressure hydrocephalus.
2. Individuals who have received a blood transfusion within the past 3 months.
3. Individuals who have active hematologic malignancies such as lymphoma or leukemia.
4. Individuals who have had a bone marrow transplant within the past 5 years.
Efficacy of Capacitive-Resistive Therapy on the Treatment of Myofascial Pain

Myofascial pain syndrome (MPS) is a painful musculoskeletal condition affecting the individuals' daily life presenting with muscle spasm, referred pain patterns, stiffness, restricted range of motion caused by trigger points. Capacitive-resistive diathermy therapy heats deep tissues by transferring energy through radiofrequency waves. Currently, although this modality is used to treat various acute or chronic musculoskeletal disorders, there is no specific data about myofascial trigger points in the literature. The investigators aimed to evaluate the efficacy of capacitive-resistive diathermy on the myofascial trigger point of neck/upper trapezius muscle area compared with the sham intervention of capacitive-resistive diathermy.

Volunteers with active myofascial trigger points in the upper trapezius and neck were included the study after being examined by sports medicine specialists. Exclusion criteria were fibromyalgia, discal hernia, radiculopathy, myelopathy, having received trigger point injection and physical therapy within the last 1 month, neck or back surgery, rheumatismal diseases, pregnancy. Patients were randomly allocated into two groups. Group 1 will be treated with capacitive resistive diathermy and exercise. Group 2 will be treated with placebo (sham) capacitive-resistive diathermy and exercise for 10 sessions at intervals of 24-48 hours. Visual analog scale (VAS), neck disability index (NDI) score, cervical range of motion (cROM), active trigger point numbers will be evaluated before and after treatment. The study was designed as a prospective, randomized, placebo-controlled double-blind trial. The study was approved by the Istanbul Faculty of Medicine Ethics Committee. All participants were informed of the study and signed written informed consent.


Eligibility Criteria:
Inclusion Criteria:

* Volunteers
* Active myofascial trigger points in the upper trapezius and neck

Exclusion Criteria:

* Fibromyalgia
* Discal Hernia
* Radiculopathy, Myelopathy
* Having received trigger point injection and physical therapy within the last 1 month
* Neck or Back surgery
* Rheumatismal diseases
* Pregnancy
PROPACT: Retrospective Prophylaxis Patient Case Collection

This study is conducted in Europe and North and South America. The primary aim of this observational study is to evaluate the frequency and pattern of bleeding episodes in haemophilia patients receiving preventative treatment with activated recombinant human factor VII. The secondary aim is to evaluate which patients are selected for this treatment, the dose and dose intervals used, and the safety of activated recombinant human factor VII when used as prevention. The study also aims to increase understanding of the unmet medical need and clinical relevance of preventative treatment in haemophilia patients.


Eligibility Criteria:
Inclusion Criteria:

* Haemophilia A or B with inhibitors
* Prescribed use of activated recombinant human factor VII for any type of prophylaxis with a duration of at least 30 days

Exclusion Criteria:

* Prophylaxis prescribed post-surgery
* One or more coagulation disorders in addition to haemophilia