cyrilzakka/clinical-trials huggingface dataset:
Comparison of Analgesic Effects of TAP Block and RSB in RALPs

In this research, we aim to compare the postoperative analgesic efficacy of these two peripheral blocks in patients undergoing RALP who have received preoperative TAP block and RSB block.

"Robotic-assisted laparoscopic prostatectomy (RALP) is a minimally invasive and superior technique that provides better visualization and maneuverability compared to open and laparoscopic surgical techniques. Previous studies have shown that RALP offers better postoperative oncological and physiological outcomes compared to open and laparoscopic techniques. However, RALP patients still experience pain lasting for several days postoperatively, which requires the use of analgesics such as opioids. This pain is associated with port site incisions, dissection of the prostate and surrounding tissues, bladder spasms, and transurethral catheter irritation. For this purpose, previous studies have utilized central and peripheral methods to reduce postoperative pain. Previous studies have demonstrated the analgesic benefits of TAP block and rectus sheath block in robotic-assisted radical prostatectomies. However, the number of studies in this area is limited. In this research, we aim to compare the postoperative analgesic efficacy of these two peripheral blocks in patients undergoing RALP who have received preoperative TAP block and RSB block.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18-79 who underwent robotic radical prostatectomy
* Patients have ASA (American Society of Anesthesiologists) physical status score of 1-3.

Exclusion Criteria:

* Patients with an allergy to local anesthetic agents
* a platelet count below 100,000
* INR value above 2
Testing Different Anti-smoking Messages Among Chinese Young Adult Smokers and Nonsmokers

Young adults are particularly vulnerable to psychological distress during the transition from adolescence to adulthood, making them more susceptible to developing persistent substance use. The tobacco industry capitalizes on this vulnerability by using marketing tactics to promote tobacco initiation and facilitate the progression from experimental tobacco use to long-term use. In China, where the average age of starting daily smoking is 21.1 years old, the number of current young adult smokers exceeds 29 million. It is crucial to develop effective communication messages to counter the tobacco industry's marketing strategies and protect the health of young adults in China. This project aims to test the effects of different anti-smoking message themes among Chinese young adults. In this online randomized clinical trial, participants will be randomly assigned to one of five antismoking message conditions. The investigators will compare the effects of these themes with each other and with the control condition.

In this study, the investigators will examine the effectiveness of different anti-smoking themes in reducing intention to smoke among Chines young adults. The study will recruit 1500 adults aged 18-25 years old, including 750 current smokers and 750 non-smokers, evenly split between male and female.

The study will be conducted through a self-administered, web-assisted online survey software. Participants will be asked to consent to participate in this study via a consent form presented at the beginning of the survey. Consented participants will be randomized to one of six conditions (each represents a level of the independent variable: anti-smoking message theme): 1) Health effects 2) Tobacco industry manipulation 3) Mental health 4) Secondhand smoke 5) Social acceptability 6) Control messages with no cigarette-related content.

The study has two sessions. In session 1, participants will complete a 20-minute survey. The survey will begin with questions assessing demographic characteristics. Then participants will be shown intervention or control messages (watch three 30-second video in each condition), and beliefs and future intention to smoke cigarettes will be assessed.

Two weeks after session 1, participants will be asked to complete a 5-minute survey in session 2 of the study. The survey will measure participants' recall of the messages and smoking behaviors in the past two weeks after message exposure.

Eligibility Criteria:
Inclusion Criteria:

* • Aged between 18-25 years old

  * Current residency in China
  * Current smokers - having smoked at least 100 cigarettes in a lifetime and currently smoking every day or some days
  * Nonsmokers - having not smoked 100 cigarettes in a lifetime and do not currently smoke cigarettes
  * Can to read, speak, and understand Mandarin Chinese

Exclusion Criteria:

* None
The Effect of Intermittent Theta Burst Stimulation on Motor Learning in Healthy Adults

This study investigates the effect of different application frequencies of intermittent theta burst stimulation on motor learning in healthy adults.


Eligibility Criteria:
Inclusion Criteria:

* being at the age of 40-75 years

Exclusion Criteria:

* visual disability
* cognitive or psychiatric problems such as dementia, depression, etc.
SOCIABLE Seniors Optimizing Community Integration to Advance Better Living With ESRD

This research is being done to find out the best ways to help people with end stage kidney disease take care of their daily lives and improve their social functioning.

Investigators want to learn whether services in the Community Aging in Place, Advancing Better Living for Elders (CAPABLE) study such as help with medications, muscle strengthening, balance training, pain management, changes to houses and improved social support can be tailored to fit the needs of older adults with kidney disease to help improve their ability to balance, walk, and take care of themselves.

People aged 60 years and older who have end stage kidney disease and have been receiving dialyses for at least 6 months, may join.

Questionnaires:

Participants will be asked to answer questions about:

* social support and social functioning
* pain and depression
* physical function

Study intervention:

Participants will be randomly assigned (by chance, like the flip of a coin) to one of two groups: participant either will receive SOCIABLE (Seniors Optimizing Community Integration to Advance Better Living with ESRD) services now, or will receive the same services in six months from now. Participants have a 50:50 chance of getting into each group

SOCIABLE services involve receiving visits with a nurse interviewer. Participants will decide how you want to improve your social function and social support.

Participants will also receive:

* a group of services called CAPABLE which include home visits from a nurse (RN) and an occupational therapist (OT) and a handyman for repairs if you need them and
* help with improving social support

All participants will receive 10 home visits (6 OT, 4 RN) plus minor home repairs and assistive devices over a 4 month period of time.

Eligibility Criteria:
Inclusion Criteria:

* 60 years and older
* End Stage Renal Disease on In-Center Hemodialysis for at least 6 months
* Functional limitations (difficulty in at least one of the following: bathing, dressing, walking across a room, grooming, getting on or off the toilet, getting on or off the bed);
* Low socioeconomic status (less than high School education, or household income \<$25,000/year)
* Signed informed consent

Exclusion Criteria:

* Inability to understand the informed consent process and give consent via signed written consent form
A Gene Transfer Study for Hemophilia A

This clinical research study is being conducted by Spark Therapeutics, Inc. to determine the safety and efficacy of the factor VIII gene transfer treatment with SPK-8011 in individuals with hemophilia A.

Hemophilia A is a condition in which blood is unable to clot effectively. It is caused by a mutation or deletion in the gene that is responsible for producing blood-clotting factor VIII protein. Individuals with hemophilia A suffer from repeated bleeding episodes, often into the joints, which can cause chronic joint disease and sometime results in death due to the inability of the blood to clot efficiently. This chronic joint disease can have significant physical, psychosocial, and quality-of-life effects, including financial burden. The current standard of care includes the use of factor-based therapies which are given either as prophylaxis or to treat bleeding, as well as new non-factor prophylaxis therapies.

Eligibility Criteria:
Inclusion Criteria:

* Males age 18 years or older
* Confirmed diagnosis of hemophilia A as evidenced by their medical history with baseline FVIII activity levels \<=2%
* Have received \>150 exposure days (EDs) to FVIII concentrates or cryoprecipitate
* Have no prior history of allergic reaction to any FVIII product
* Have no measurable inhibitor against FVIII as assessed by the central laboratory and have no prior history of inhibitors to FVIII protein and no clinical signs or symptoms of decreased response to FVIII administration
* Agree to use reliable barrier contraception

Exclusion Criteria:

* Evidence of active hepatitis B or C
* Currently on antiviral therapy for hepatitis B or C
* Have significant underlying liver disease
* Have serological evidence\* of HIV-1 or HIV-2 with CD4 counts ≤200/mm3 and who are on an antiretroviral drug regimen (\* participants who are HIV+ and stable with CD4 count \>200/mm3 and undetectable viral load are eligible to enroll)
* Have detectable antibodies reactive with AAV-Spark200 capsid
* Participated in a gene transfer trial within the last 52 weeks or in a clinical trial with an investigational product within the last 12 weeks
Different Type Ultrasound Guided Epidural Block Methods

The nerve blocks applied with ultrasonography are used for pain and operation after many operations today.

Applications with ultrasonography shorten the processing time, reduce the amount of local anesthetic used and lead to fewer complications.

However, the use of ultrasonography is not so common in neuraxial regional anesthesia applications. In the literature, epidural applications accompanied by ultrasonography were applied with different approaches.

In this study the investigators will used the two different ultrasound -guided epidural block approach .

Paramedian sagittal oblique and Transverse interlaminar. The investigators will used this two technique in epidural catheter placement using the real-time ultrasound.

Eligibility Criteria:
Inclusion Criteria:

* Patients who were in the American Society of Anesthesiologists (ASA) I-III class
* Patients whom need medical epidural anesthesia
* Patients with consent to participate in the study

Exclusion Criteria:

* Patients with a known history of back surgery
* Bleeding diathesis disorder
* Allergy to local anesthetics
* Patient refusal
A Study to Evaluate the Efficacy of Diabetes Management Based on Ubiquitous Healthcare System

The aim of this study is to investigate whether adding tailored mobile coaching system to present community primary care for diabetes management would result in better glycemic control and other diabetes-related outcomes in adult patients with type 2 diabetes, compared with maintaining usual diabetes management only.

The incidence and prevalence of type 2 diabetes is increasing rapidly worldwide. Considering the fact that complications of diabetes result in greater expenditure and reduced productivity is a socioeconomic concern, adequate glycemic control is important not only as individual health problem but also as challenge to healthcare systems worldwide. To support patients' behavior change efforts, including healthy lifestyle choices, disease self-management, and prevention of diabetes complication, multifaceted professional interventions are needed. Ubiquitous healthcare based on information and communication technology is one of these approaches.

The aim of this study is to investigate whether adding tailored mobile coaching system to present community primary care for diabetes management would result in better glycemic control and other diabetes-related outcomes in adult patients with type 2 diabetes, compared with maintaining usual diabetes management only.

Eligibility Criteria:
Inclusion Criteria:

* Korean policyholders with type 2 diabetes;
* Aged ≥ 19 years;
* Smartphone users;
* Glycated hemoglobin (HbA1c) ≥ 6.5% within 3 months.

Exclusion Criteria:

* Currently had serious concomitant disease other than diabetes;
* Had admission histories due to malignancy, myocardial infarction, cerebral infarction, or organ transplantation;
* Pregnant or had plan for pregnancy within 6 months;
* Planned for attending other clinical;
* Illiteracy.
Waitlist-Control Trial of Smartphone Cognitive Behavioral Therapy (CBT) for Body Dysmorphic Disorder (BDD)

The investigators are testing the efficacy of Smartphone-delivered cognitive behavioral therapy (CBT) treatment for body dysmorphic disorder (BDD). The investigators hypothesize that participants receiving app-CBT will have greater improvement in body dysmorphic disorder symptom severity than those in the waitlist condition at treatment endpoint (week 12).

The primary aim of this study is to test the efficacy of a Smartphone-based cognitive behavioral therapy (CBT) treatment for adults with body dysmorphic disorder (BDD) recruited nationally. In a prior study (Clinical Trials Identifier # NCT03221738), the investigators developed and pilot-tested the feasibility, acceptability, and preliminary efficacy of a CBT for BDD app in an open pilot trial. The investigators are now further testing these outcomes in a randomized controlled trial. Eligible subjects (N= 64) will be randomly assigned to 12-weeks of Smartphone-delivered CBT for BDD either immediately, or after a 12-week long waiting period (50/50 chance).

Eligibility Criteria:
Inclusion Criteria:

* at least 18 years of age
* current diagnosis of primary body dysmorphic disorder (BDD), based on a clinical structured diagnostic interview
* currently living in the United States

Exclusion Criteria:

* Psychotropic medication changes within 2 months prior to enrollment (Participants taking psychotropic medication must have been on a stable dose for at least 2 months prior to enrollment and not change medication during study period)
* Past participation in 4+ sessions of cognitive behavioral therapy (CBT) for body dysmorphic disorder (BDD)
* Current severe substance use disorder
* Lifetime bipolar disorder or psychosis
* Acute, active suicidal ideation as indicated by clinical judgment and/or a score \>2 on the suicidal ideation subscale of the Columbia-Suicide Severity Rating Scale (C-SSRS).
* Current severe comorbid major depression, as indicated by clinical judgment and/or a Quick Inventory of Depressive Symptomatology- Self Report (QIDS-SR) total score ≥ 21
* Concurrent psychological treatment
* Does not own a supported Smartphone with a data plan
* Lack of technology literacy that would interfere with ability to engage with smartphone treatment
Infective Keratitis in Minia Governate

The purpose of the study is to determine the microbiological aetiology, epidemiological factors, and clinical profile and treatment outcomes of infective keratitis in Ophthalmology department, Minia University. Egypt

Prospective, non-randomized, observational clinical series of cases, including 150 patients clinically diagnosed as infective corneal ulcer, attending the Ophthalmology Department - Faculty of Medicine. Minia University, Minia, Egypt. From 2018 to 2020.

Detailed history taking and all clinical findings were collected. Corneal scrapings were obtained from patients and subjected to staining and culture for bacterial and fungal pathogens; Bacterial and fungal growth were identified by standard laboratory procedures.

Eligibility Criteria:
Inclusion Criteria:

* clinically diagnosed as infective corneal ulcer, attending the Ophthalmology Department - Faculty of Medicine - Minia University, Minia, Egypt

Exclusion Criteria:

* healed keratitis
CD8 Minibody Repeatability Study

Zr-89 crefmirlimab berdoxam is a Zirconium-89 labelled minibody developed by ImaginAb for full body PET imaging of CD8+ cell distribution (CD8 ImmunoPET). The primary objective of this study is to assess the test-retest repeatability of CD8 immunoPET imaging in oncology patients with stable disease.


Eligibility Criteria:
Inclusion Criteria:

* Aged 18 years and above
* Patients with at least one imageable primary or metastatic lesion \> 1 cm in the lymph nodes or soft tissue excluding bone on the most recent standard of care imaging done within the last 3 months
* Cohort 1: Patients with melanoma on single or multiple agent Immune Checkpoint Blockade (ICB) therapy with stable response status following initiation of therapy. Stable disease would be observed over at least 2 consecutive standard of care CT scans (usually done 8-12 weeks apart) after initiation of therapy.
* Cohort 2: Patients with untreated renal cell carcinoma on active surveillance
* Women of child bearing potential must not be pregnant on study entry
* Participants must agree to follow contraceptive advice while on study and for 30 days after ending participation.

Exclusion Criteria:

* Patients with uncontrolled infection or other concurrent malignancies or conditions that may confound interpretation of the scans in the opinion of the investigator
* Patients with urinary catheters or stoma bags
* Patients who have received a vaccine recently can be included to the study but can only be scanned after a washout period of 2 weeks after the vaccine. If participants have a vaccine after the first PET-CT scan, the second PET-CT scan will be delayed for at least 2 weeks after the vaccine
* Patients on steroids except those on replacement dose of steroids for adrenal or pituitary insufficiency. Patients requiring steroids as therapy for an unresolved immune therapy related adverse event will be excluded
* Participants on immunosuppressive medication e.g. cyclosporine, azathioprine, janus kinase inhibitors
* Participant enrolled into another therapeutic intervention study
* Any other contraindication that makes the patient unsuitable to take part in the study in the opinion of the investigator
* Women who are pregnant or breast feeding
* Unable to provide informed consent
Evaluation Nutrition Education Intervention on Pulse and Cereal Mix for Complementary Food in Southern Ethiopia

The overall purpose of the study is to evaluate nutrition education interventions to promote pulse incorporated complementary food to the wider rural community through the government system to improve maternal knowledge, attitude and practice (KAP) and nutritional status of young children (6 to 24 months). The hypothesis is that nutrition education improves mothers knowledge, attitude and practice of pulse incorporated complementary food and improves dietary intake of iron and zinc and nutritional status of young children.

Only 9% of the population in Southern Ethiopia consumes pulse and pulse total contribution of the diet is less than 4.9% for women and less than 3.3% for children.Young children are at risk of developing malnutrition because of dietary inadequacy. Educational interventions can improve feeding practices and growth of young children. The overall purpose of the study is to evaluate nutrition education interventions to promote pulse incorporated complementary food to the wider rural community through the government system to improve maternal knowledge, attitude and practice (KAP) and nutritional status of young children (6 to 24 months). The hypothesis is that nutrition education improves mothers knowledge, attitude and practice of pulse incorporated complementary food and improves dietary intake of iron and zinc and nutritional status of young children. Before, at midline and end of the intervention we will assess the KAP of mothers, dietary intake of iron and zinc and nutritional status of young children. The nutrition education intervention will be given for 9 months. Serum ferritin, serum zinc, C-Reactive protein and hemoglobin and dietary intake of iron and zinc of young children will be measured at the beginning and ending of the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Age 6-15 months
* Apparently healthy
* Being breastfed at time of recruitment
* The mothers are permanent residents of the kebele

Exclusion Criteria:

* Infant undergoing treatment with supplemental foods for malnutrition
The Effect of Nasal Carbon Dioxide (CO2) in the Treatment of Seasonal Allergic Rhinitis

The purpose of this study is to evaluate the safety and effect of nasal carbon dioxide in the treatment of Seasonal Allergic Rhinitis

This multi-center, randomized, double-blind, placebo-controlled, parallel group trial will evaluate the efficacy and safety of a nasal, non-inhaled administration of carbon dioxide (CO2) in patients with seasonal allergic rhinitis. An estimated 500 patients who meet the eligibility criteria will be enrolled into this study at approximately 25 sites to ensure that approximately 400 patients are randomized and complete the study.

Eligibility Criteria:
Inclusion Criteria:

* Able to read and understand informed consent and voluntarily consent to sign the informed consent form
* Able to comply with the requirements of the protocol (e.g., complete the diary within the protocol-specified window)
* Minimal 2-year history of Fall seasonal allergic rhinitis requiring pharmacotherapy
* Positive skin test to one or more Fall seasonal allergen (e.g., ragweed, birch pollen, etc.)
* Females of childbearing potential must commit to using an acceptable method of birth control and have a negative pregnancy test

Exclusion Criteria:

* History of asthma (other than mild intermittent)
* Acute or significant sinusitis or upper respiratory infection within 14 days of enrollment
* Existing serious medical condition (e.g., severe emphysema) that precludes participation
* Females who are pregnant or breast-feeding and/or who plan to become pregnant or to breast-feed during the study participation or within 7 days after the last study drug administration
* Initiation of immunotherapy or have a change in immunotherapy dose within the 6 months preceding enrollment (if on immunotherapy, the same dose must be maintained throughout the trial)
* Planned travel outside the study area for the duration of study period
* Participation in another clinical study within 30 days of planned enrollment date and for the duration of the study
* Participation in a previous study with Nasal CO2
Lipoprotein Effects of Substituting Beef Protein for Carbohydrate

The purpose of this study is to test whether replacing dietary carbohydrate with protein, using beef as the primarily source of protein, will improve risk factors for cardiovascular disease.

The primary aim of this study is to test the hypothesis that replacing dietary carbohydrate with protein, using beef as the primarily source of protein, will have beneficial effects on components of atherogenic dyslipidemia and postprandial lipoprotein response and that these effects will be independent of saturated fat intake.

Eligibility Criteria:
Inclusion Criteria:

* Blood pressure less than 150/90
* Body mass index (BMI)≥ 20 and ≤ 35 kg/m2
* Non-smoker
* Agrees not to consume alcohol during the study
* Agrees to abstain from taking dietary supplements during the study
* LDL-cholesterol and total cholesterol \< 95th percentile for age and sex
* Fasting triglycerides \< 500 mg/dL
* Fasting glucose concentration \< 126 mg/dL
* Hematocrit (HCT) ≥ 36%
* At least three months of a weight-stable state (± 3% of body weight)

Exclusion Criteria:

* Personal history of coronary heart disease, cerebrovascular disease, peripheral vascular disease, diabetes, lung disease, bleeding disorder, liver or renal disease, HIV or of cancer (other than skin cancer) in the last five years
* Taking drugs known to affect lipid metabolism or insulin resistance, hormones, or the blood thinning agent warfarin
* Abnormal thyroid stimulating hormone (TSH)
* Strength trains with resistance weights more than four hours per week