cyrilzakka/clinical-trials huggingface dataset:
The Effect of Pork With Modified Fat Composition and Berries on Plasma Fatty Acids and Fecal Compounds in Healthy Adults

High consumption of red meat is related to cardiovascular diseases. Red meat containing more unsaturated fat than normal red meat may have a beneficial impact on plasma lipid and fatty acid profile in humans. Furthermore, consumption of red meat and especially processed red meat is considered harmful to colon health. However, consumption of fruit and berries rich in antioxidants and flavonoids may provide protection when red meat is consumed.

The study aims to answer whether the fatty acid profile of pork when modified towards more unsaturated fat will affect plasma fatty acids and lipids in adult volunteers. The effects of pork with a modified fatty acid content is compared with conventional pork with lower unsaturated fat content. Fatty acid composition of pork is modified by altering the composition of animal feed.

The other arm of the study investigates the effects of consuming berries together with red meat on gut metabolism. The study focuses on how berries affect the formation of fecal compounds known to be related to high red meat consumption, such as N-nitroso compounds.


Eligibility Criteria:
Inclusion Criteria:

* diet includes meat

Exclusion Criteria:

* high consumption of fish (4 times per week)
* use of fish oil/ omega-3 oil capsules one month before the intervention
* hypercholesterolemia
* vegetarian, vegan
Comparison of PNF and Task Related Techniques Along With Tens on Upper Limb Function Among Stroke Patients

Comparison of PNF and Task Related Techniques Along with Tens on Upper Limb Function Among Stroke Patients

The objective of this study is to determine the comparison of PNF and TRT along with TENs on upper limb function recovery among stroke patients.

Eligibility Criteria:
Inclusion Criteria:

* Duration of illness before participation in the study ranged from six to eighteen months' post stroke.
* Patients who diagnosed with ischemic stroke stage 2 and 3
* Patients' age ranged from 50-70 years (male/female)
* Patients with sufficient cognitive abilities that enables them to understand and follow instructions (mini mental scale)

Exclusion Criteria:

* Patients with communication problems
* Patients with a history of previous stroke or other neurological diseases or disorders
* Patients with inflammation, old fracture or prosthesis in the affected limb, neurological diseases that affect upper limb function other than stroke (e.g.: Multiple sclerosis, Peripheral neuropathy, Parkinsonism .... etc.), infection or dermatological conditions on acupuncture sites, musculoskeletal disorders such as severe arthritis, cardiovascular problems (unstable angina, recent myocardial infarction within the last three months, congestive heart failure, significant heart valve dysfunction, arrhythmia, implanted pacemaker or unstable hypertension) or pulmonary disorders, visual and auditory problems and patients with cognitive impairment.
* Any Contra indications for TENS, Other neurological \& orthopedic conditions affecting upper limb, Patient with subluxed shoulder, Patient with shoulder hand syndrome.
Telerehabilitation in Oncology Patients

The aim is to analyze the feasibility and effect of an online Therapeutic Exercise and Education programme (TEEP) in cancer patient and survivors

Current literature shows that Therapeutic Exercise has multiple benefits in oncology patients, such as improvements in function and quality of life, and ameliorates symptoms such as cancer-related fatigue. Furthermore, given the risk of obesity, both exercise and diet play a key role in recovery from cancer. In fact, current guidelines support the use of exercise with therapeutic purposes as a complement to cancer treatment.

As a consequence of the COVID-19 pandemic, oncology patients present more difficulties to attend programs, as the vast majority are immunosuppressed, and they are considered risk population. Therefore, new online (TEEP) must be developed to facilitate the benefits of these programs in the post-COVID Era. This study analyses the feasibility (in terms of suitability and verification of exercise prescription, absence and attendance type, and total days of attendance) and the effect (in weight, physical function, and symptoms) in cancer patients and survivors.

Eligibility Criteria:
Inclusion Criteria:

* Metastatic breast patient, gynecological cancer patient, or breast cancer survivor under adjuvant treatment after surgical intervention.
* Having given informed consent to participate voluntarily in the program and to be in contact via telematics (email or messaging platform).
* Have a good internet connection
* Be accompanied by an adult on the day of assessment.
* Availability to access the computer on during the intervention.

Exclusion Criteria:

* Technophobia
* Domatophobia or self-report of adversity to be at home.
* Lack of logistical requirements (Internet and lack of skill in its use).
Proprioceptive Postural Control and Chronic Obstructive Pulmonary Disease (COPD)

Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Increased risk of falling is reported in individuals with chronic obstructive pulmonary disease. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance.

The aim of the study is to clarify whether proprioceptive postural control is impaired in individuals with chronic obstructive pulmonary disease.


Eligibility Criteria:
Inclusion Criteria individuals with chronic obstructive pulmonary disease:

* Age: 40-80 years old
* Spirometry (post-bronchodilator) based diagnosis of COPD (GOLD criteria)
* Willingness to sign the informed consent

Inclusion Criteria healthy controls:

* Age: 40-80 years old
* No COPD (spirometry based: FEV1/FVC ≥ 0.7 and FEV1 \> 80%)
* Willingness to sign the informed consent

Exclusion Criteria:

* History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant
* One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder
* Respiratory disorder other than COPD
* α1-antitrypsin deficiency
* Known history of significant inflammatory disease other than COPD
* COPD exacerbation within 4 weeks prior to study
* Lung surgery
* Recent diagnosis of cancer
* Therapy with oral corticosteroids in the last 6 weeks
* Significant cardiovascular comorbidity
Randomized Clinical Trial of Phonological Interventions

Recent research reveals genetic and symptomatic overlap among children with speech sound disorders (i.e., those who (misarticulate more sounds than would be expected for their age) and children with dyslexia (i.e., those who struggle to learn to read). Children who have speech sound disorders as preschoolers are at risk for the later emergence of dyslexia, a risk that often reveals itself in the form of poor phonological awareness skills during the preschool period. Traditional speech therapy methods focus on articulation accuracy and do not focus on the child's more abstract knowledge of the sound system of the language. The ultimate objective of this research program is to prevent reading disability in children who present with speech sounds disorders. The relative effectiveness of different interventions to help these children achieve age-appropriate phonological processing skills prior to school entry will be investigated. It is expected that a combination of treatment approaches that focus on speech perception skills and vocabulary knowledge will have a superior impact on phonological awareness in comparison with a treatment approach that focuses solely on articulation accuracy.

The 72 children participating in the study will be randomly assigned (with concealment of the randomization sequence from study staff) to one of two Child Speech Interventions: Speech Perception or Speech Production. These interventions will be provided in individualized one-hour treatment sessions once per week for six consecutive weeks during the first treatment block. During the second 6 week treatment block all children will receive a group phonological awareness intervention. Concurrently their parents will be randomly assigned to receive instruction in the provision of a home program, either Articulation Therapy or Dialogic Reading. This will result in 4 groups of 18 children with each group receiving one of four combinations of intervention: Speech Production Intervention + Articulation Parent Group; Speech Production Intervention + Dialogic Reading Parent Group; Speech Perception Intervention + Articulation Parent Group; and Speech Perception Intervention + Dialogic Reading Parent Group. Assessments will occur pretreatment, after the first treatment block, after the second treatment block, and 9 months after the end of the second treatment block.

Eligibility Criteria:
Inclusion Criteria:

* primary diagnosis of speech articulation disorder/phonological impairment
* age 4 to 5 years of age at onset of treatment
* maternal language Canadian French (at least 75% exposure)
* must misarticulate at least two phonemes that would typically be mastered by their normally developing age peers

Exclusion Criteria:

* speech disorder is secondary to a primary condition (e.g., hearing impairment, cleft palate, autism, Down syndrome etc.)
Effects on Pes Planus Exercise Training Mixed With Play on Pre-school Children

The study was planned to assess effects on pes planus and femoral anteversion angle of exercise training mixed with play on pre-school children.

Pes planus ( Pes planovalgus) is similar with flatfoot occurs collapse of medial longitudinal arch which is lower than normal range or occurs extra pressure on arch. It is separated two group such congenital (flexible and rigid) and acquired. The etiology of pes planus is that hallux rigidus, plantar calcaneonavicular ligament rupture, collapse of medial longitudinal arch, pathology of ligament and tendon, shortness Achilles tendon and juvenile hallux valgus. The most common causes of pes planus are outgroup of leg muscles (peroneal) spasticity, plantar fasciitis and tibial tendon insufficiency. Symptoms of pes planus are indicated heel pain, gait abnormalities, decreased dorsiflexion range of ankle, plantar ulceration, limited mobility of 1.metatarsophalangeal joint and spasm of peroneal muscle. There is a high prevalence rates among males and occur positive correlation between with pes planus and BMI. Evaluation methods of pes planus are X-ray, heel height, gait analysis and Achilles strain. The most commonly used method are line that medial malleolus, 1st metatarsal head and the navicula is on the same line, and the footprint technique from ink rubber plates. Treatment of pes planus is maintained medial displacement calcaneal osteotomy operation with the transfer of the flexor digitorum longus. Non- invasive treatment methods are given such as peroneal muscles and Achilles stretching exercises. 25 degree angle inverted foot orthoses are commonly used because of increasing stance phasic in treatment. Peroneal neural mobilization, play training and stretching exercises are often used treatment method of pes planus. Main purpose of this study is that assess effects of mixed training program with playing on pes planus and increased femoral anteversion angle in pre-school students.

Eligibility Criteria:
Inclusion Criteria:

* Children in an age range of 4-7 years,
* Having bilateral or unilateral deformity with pes planus
* CSI range \> % 62.7 measured by the referring physical therapist.
* Having no any foot surgeon,
* Without any neurological diseases,
* Who want to be involved voluntary work,
* Pre-school students who have been informed by their families(their families approved illuminated affirmation ).

Exclusion Criteria:

* Pre-school students who can not adapt to training,
* Students who do not want to be involved in voluntary work.
Survey of Inpatients on Integrative Therapy Methods

Observational study of general patient satisfaction and inpatients' experiences with integrative therapies. The study recruits inpatients of the Filderklinik, an anthroposophic hospital in southwestern Germany. The aim is to assess overall patient satisfaction and inpatients' experiences with integrative therapies at the Filderklinik.

This is a cross-sectional study to investigate general patient satisfaction and inpatients' experiences with integrative therapies in an anthroposophic hospital. Participants will be recruited at the Filderklinik, a hospital in southwestern Germany that uses anthroposophic medicine (AM) on a broad basis. Inpatients who have received at least 10 treatments with one or more of the different integrative therapy methods will be asked for their willingness to participate. After providing written informed consent, participants will complete a questionnaire on integrative therapies received and overall patient satisfaction. In addition, data from the clinic database will be analyzed and cross-checked with the questionnaire data to verify and specify information about the participating sample. The focus of the study is to assess general patient satisfaction and experience with integrative therapy methods among inpatients at the Filderklinik.

Eligibility Criteria:
Inclusion Criteria:

* Written informed consent
* Filderklinik inpatient who had at least 10 treatments with one ore more of the integrative therapy methods
* Age 18 years or older

Exclusion Criteria:

* Insufficient German language skills
* Legally incapacitated patients
* Patients who are physically incapable of giving written consent
* Patients in isolation wards
Evaluation of Nutritional Status in ICU : Interest for the Measurement of Body Composition by Body Bioelectrical Impedance and Comparison With Several Methods

Prospective cohort, monocentric non-randomized and interventional clinical study in ICU assessing the evolution of body composition using bioelectrical impedance analysis.

Prospective, monocentric non-randomized and interventional clinical study in ICU assessing the evolution of body composition using bioelectrical impedance analysis (phase angle, fat mass, muscle mass, fat-free mass, body water); comparison with four methods for assessing nutritional status. ; compare length of mechanical ventilation, length in ICU and energy expenditure rest between malnourished and non-malnourished patient.

Eligibility Criteria:
Inclusion Criteria:

* ICU patients
* Written informed consent
* Adult patient

Exclusion Criteria:

* Pregnant patient
* Cardiac -pacemaker
Ultrasound for Perfusion in Neonates

The purpose of this study is to evaluate the effectiveness of renal ultrasound to check kidney perfusion in premature and/or very low birth weight babies.

The purpose of this study is to evaluate the effectiveness of 3D (3 dimensional)renal ultrasound to check kidney perfusion (to see if the kidney is receiving enough blood flow to function as it should) in premature and/or very low birth weight babies.

Eligibility Criteria:
Inclusion Criteria:

* Very low birth weight babies in ICU in stable condition and/or premature babies in ICU in stable condition

Exclusion Criteria:

* Unstable very low birth weight/premature babies
Antibiotic Use in a Neonatal Intensive Care Unit Practicing Integrative Medicine

The goal of this study is to describe the antibiotic use in a neonatal intensive care unit (NICU) in Germany that is practising integrative medicine. The investigators will review hospital records to find out how often and how long antibiotics were given to newborns; compare antibiotic use to other NICU in the same area; describe how sick infected newborns were (comparing those treated with or without antibiotics); and describe which anthroposophic medicines were used, how often and if there were safety problems.

A retrospective study, analysing antibiotic use in a level 2 neonatology intensive care unit (NICU) in Germany over a 4-year period from 2014 to 2017. The study will analyse frequency of antibiotic prescribing; compare antibiotic use to other level 2 NICU; compare clinical and laboratory parameters among neonates with infectious disease diagnosis managed with or without antibiotics; use and tolerability of anthroposophic medicinal products.

Eligibility Criteria:
Inclusion Criteria:

* Admission to neonatal intensive care unit

Exclusion Criteria:

* None
Quality of Recovery After Hip Fracture Surgery: US-guided PENG Block Versus FICB

Patients were randomly divided into two groups to receive either ultrasound-guided pericapsular nerve group block (PENG group) or fascia iliaca compartment block (FICB group), using 20 ml of 0.2% ropivacaine

Participants were randomly divided into two groups : group PENG and group FICB, to receive either ultrasound-guided pericapsular nerve group block or fascia iliaca compartment block, using 50 ml of 0.2% ropivacaine.

For the FICB, a linear ultrasound probe was placed in the transverse plane and start scanning at the level of the inguinal crease to identify the femoral artery medially and the femoral nerve lateral to the femoral artery. The iliopsoas muscle should be seen overlying fascia iliaca. The block should be performed proximal to the arterial bifurcation. A 50 mm needle was introduced using an in-plane approach to penetrate the fascia iliaca. The hydro dissection separate the fascia iliaca from the iliac muscle, and a total volume of 20 ml of 0.2% ropivacaine was injected in this created space.

The PENG bloc is performed with a low frequency curvilinear ultrasound probe, which was initially placed in a transverse plane over the antero inferior iliac spine and the aligned with the pubic ramus by rotating the probe counterclockwise approximately 45 degrees. In this view, it is possible to observe the iliopubic eminence, the iliopsoas muscle tendon, the femoral artery and the pectineus muscle. A 100 mm needle was inserted from lateral to medial in an in-plane approach to place the tip in the musculofascial plane between the psoas tendon anteriorly and the pubic ramus posteriorly. Negative aspiration should be observed before injection of local anaesthetic and a total volume of 20 ml of 0.2% ropivacaine was injected.

Spinal anesthesia was performed after 20 minutes.

QoR-15 score was assessed before the intervention and 24 hours postoperatively.

Eligibility Criteria:
Inclusion Criteria:

* patients aged above 65 years
* patients with an american society of anesthesiologists physical status I to III
* patients undergoing hip fracture surgical repair

Exclusion Criteria:

* patients with an american society of anesthesiologists physical status IV or more
* inability or refusal to sign informed consent
* contraindications for regional nerve block or spinal anesthesia
* impaired cognition or dementia
Pharmacokinetic Study of Palifermin in Subjects Receiving Radiation Therapy and Chemotherapy Followed by Blood Stem Cell Support

Open label palifermin will be administered to subjects who are at a risk of developing mucositis after radiotherapy and chemotherapy followed by blood stem cell support. The amount of palifermin in the blood following administration will be evaluated. The safety of palifermin administration and its effect on reducing mucositis will also be evaluated.

Mucositis is a common side effect to chemotherapy and radiotherapy involving the formation of erythema and ulcerative lesions in the mouth. Mucositis can be serious, resulting in pain requiring interventions such as analgesic medications and the use of parenteral feedings. Currently, no standard therapy is available to prevent or treat mucositis.

Eligibility Criteria:
* Patients diagnosed with Non-Hodgkin's Lymphoma, Hodgkin's Disease, Leukemia and Myeloma. - Eligible for treatment with radiation therapy and chemotherapy followed by blood stem cell support.
Thymosin-alpha 1 for Adjuvant Treatment After Radical Resection of High-risk Stage II and III Colorectal Cancer

For high-risk stage II and stage III colorectal cancer, even after radical resection and postoperative adjuvant chemo/radiotherapy, 30-40% of patients will still have recurrence and metastasis. Thymosin-alpha 1 is believed to improve immunity and may help promote tumor immunity to reduce the incidence of recurrence and metastasis. This study hopes to verify the effecacy and safety of thymosin-alpha 1 for adjuvant treatment of high-risk stage II and stage III colorectal cancer after radical resection.

Patients with pathological high-risk stage II and stage III colorectal cancer after radical resection were randomly allocated to receive thymosin-alpha 1 twice a week for 6 months (experimental group) or not (control group) in a 1:1 ratio. At the same time, all patients will receive chemo/radiotherapy according to the Chinese Standards for Diagnosis and Treatment of Colorectal Cancer. The primary endpoint is 3-year DFS rate.

Eligibility Criteria:
Inclusion Criteria:

* Colorectal cancer receiving radical resection
* Pathologically diagnosed with high-risk stage II or stage III
* Eastern Cooperative Oncology Group performance status of 0-2
* Adequate hepatic, renal, and hematologic function

Exclusion Criteria:

* Had previously taken any immune-promoting drugs
* Pregnancy or lactation
CHIPs or College Health Intervention Projects

The goal of the study is to test the efficacy of brief clinician advice in reducing the frequency of high-risk drinking and alcohol-related harm in a population of college students seeking care at five university health care clinics. High-risk drinking is defined as 1) 8 or more episodes of heavy drinking (5 or more drinks in a row) in the past 28 days for male and female students, and/or 2) 50 drinks for male and 40 drinks for female students in the past 28 days, and/or 3) 15 drinks for male and 12 drinks for female students in the past 7 days, and/or 4) One or more episode(s) of heavy drinking which includes 15 or more drinks in a row.


Eligibility Criteria:
Inclusion Criteria:

* subjects who screen positive for high risk drinking on the Health Screening Survey (HSS) and Baseline interview

Exclusion Criteria:

* Students who will be leaving campus due to graduation or for an extended absence prior to the first face to face intervention Female students who are pregnant at the time of randomization Students who are currently suicidal at the time of the baseline interview Students under 18 years of age Students who drink more than 200 drinks in 28 days (referred for treatment).
Descriptive Analysis of Clinical Outcomes in Patients With Prostate Gland Cancer, Which Spreads to Other Parts of the Body, Who Were Treated First With Novel Anti-hormone Therapy Followed by a Second Line Treatment With Novel Anti-Hormone Therapy or RadIum-223 (Xofigo).

In this study researcher want to learn more about the overall survival in patients suffering from prostate gland cancer which spread outside the prostate to other parts of the body who received either a novel anti-hormone therapy (NAH) or Radium-223 (Xofigo) after a prior NAH therapy (first line treatment). Additionally the researchers are also interested in the occurrence of bone fractures and other skeletal events. Basis for this study will be the US based Flatiron database which provides access to clinical data for cancer patients.


Eligibility Criteria:
Inclusion Criteria:

* Patients with documented mCRPC receiving 1L NAHs.
* Initiation of Ra-223 after 1L NAH therapy, or
* Initiation of sequential NAH therapy after 1L NAH therapy

Exclusion criteria:

* Patients involved in clinical trials
* Patients who received combined therapies in 1L or 2L