cyrilzakka/clinical-trials huggingface dataset:
Effect of Kinesiology Tape on Quadriceps Strength and Performance in Female Futsal Players

The purpose of this randomized controlled trial is to investigate whether kinesiology tape improves quadriceps muscle efficiency in female futsal players. The study aims to answer whether the application of kinesiology tape enhances lower limb function, isometric strength, and eccentric/concentric strength compared to no intervention.

This study explores the potential benefits of kinesiology tape in improving quadriceps muscle performance in female futsal players, a demographic actively engaged in high-intensity sports. The trial was designed to provide robust evidence on whether kinesiology tape can enhance functional and physical performance of the lower limb, addressing a gap in sports medicine research.

The study involved 12 players participating in the Saudi Universities Sports Federation (SUSF) Futsal Championship. Participants were randomly assigned to two groups: an experimental group receiving kinesiology tape intervention and a control group with no intervention. The intervention was conducted over 30 days, with a focus on assessing the impact of kinesiology tape on the dominant leg, targeting key muscles like the rectus femoris, vastus medialis, and vastus lateralis.

To ensure comprehensive evaluation, participants underwent assessments using validated tools for lower limb function, isometric strength, and dynamic strength (eccentric/concentric). These tools included the Single-Leg Hop Test, a hand-held dynamometer, and the Biodex System, which provided precise and reliable measurements of muscle performance.

Eligibility Criteria:
Inclusion Criteria:

* Female futsal players
* Body Mass Index (BMI): 18.5-25 kg/m2.
* Regular participation in sports activities.
* No history of kinesiology tape application on the thighs within six months prior to the study.

Exclusion Criteria:

* Medical history of knee or back pain, lower-limb surgeries, or joint deformities.
* Known allergies to kinesiology tape or conditions such as diabetes, fragile skin, pregnancy, open wounds, or deep vein thrombosis.
* Recent muscular injuries of the lower limbs within six months prior to the study.
* Any other conditions or contraindications that could interfere with participation or the outcomes of the study.
Functionality of an 8-Channel Paddle Coil for Use With MRI

The objective of this study is to determine the functionality of an eight-channel paddle coil system which is to be used in future MRI studies.

Prostate cancer is the most common malignancy among men and the second leading cause of cancer death in men. Currently, MRI is the best imaging modality for both detecting prostate cancer and determining the presence of extra-prostatic extension. Multiparametric Magnetic Resonance, combining T2-weighted, diffusion-weighted and dynamic contrast enhanced imaging (DCE-MRI) is recommended as the minimum acceptable standard for prostate MRI examination. However, MPMRI still lacks diagnostic accuracy in the transition zone, where distinguishing cancer from proliferative nodules has proven difficult. DCE-MRI techniques evaluate the time course of signal intensities after administration of a contrast medium and have been used to successfully differentiate benign from malignant tumours, particularly in breast and prostate cancer. Unfortunately, current DCE approaches have high false-positive rates and are limited in distinguishing prostatitis and vascularized BPH nodules from cancer in active surveillance studies. Future studies that employ spectroscopic MR imaging of the prostate after administration of Hyperpolarized (13C) Pyruvate Injection, are expected to provide a robust, non-invasive method to assist in detecting and characterizing prostate cancer. The objective of this study is to determine the functionality of an eight-channel paddle coil system which is to be used in future Hyperpolarized (13C) Pyruvate Injection studies.

Eligibility Criteria:
Inclusion Criteria:

* Healthy male volunteers between 18 and 80 years of age

Exclusion Criteria:

* Any contra-indication for MR imaging (such as pacemakers, surgical implants, foreign metal objects in the body)
The Effect of Care Given Using Levine's Conservation Model on Postpartum Quality of Life in Primiparas

Background: Postpartum period is a physiologically, emotionally and socially critical period for the woman who gave birth and also for their family. In order for women to go through their postpartum period without any problems, be able to perform self-care and have an unaffected quality of life, they need qualified, comprehensive and integrative nursing care.

Aim and objectives: This study aimed to investigate the effect of care given using Levine's conservation model on postpartum quality of life in primiparae.

Design: A randomized controlled trial. Methods: Levine's conservation model was used as the theoretical framework for this study. A literature review was used to determine the contents of the intervention program. The program consisted of 8 sessions. The puerpera were given trainings on different subjects based on the module during each session. For these trainings, the researcher prepared, in the light of the literature data, leaflets containing information about breastfeeding, personal hygiene, fatigue, nutrition and pilates exercises. The puerpera in the control group received only the standard nursing care given after birth. Standard nursing care contain solely breastfeeding training.


Eligibility Criteria:
The study included puerpera who

* were in the 18-35 age interval and were at least a primary school graduate,
* had no loss of their senses of vision or hearing,
* were open to communication and cooperation,
* had a nuclear type of family,
* were able to understand and read Turkish,
* were primiparae,
* had a full-term (between weeks 38-42) vaginal delivery,
* had a haemoglobin value of at least 10 mg/dl,
* experienced no risky conditions during gestation (placenta previa, pre-eclampsia, any systemic ailment) or during delivery (ablatio placenta, dystocia, etc.),
* were administered mediolateral episiotomy (because episiotomy impair the integrity of tissue. Healing such episiotomy incisions as soon as possible is quite important to conserve structural integrity).

Exclusion Criteria:

- those who do not meet the eligibility criteria
Locally Delivered 1% Metformin Gel in Peri-implantitis

This study evaluates the efficacy of 1% local metformin gel in deep periimplant pockets of type 2 diabetes mellitus patients. Half of the participants will receive 1% metformin gel with manual debridement while the other half will receive a placebo with manual debridement.

Metformin is an oral hypoglycemic drug categorized under biguanide and are considered the most efficient agents widely used in the treatment of type 2 diabetes mellitus.The general clinical benefits observed in therapy with MF seem to be greater than expected. They induce osteoblast cells to promote early bone formation through AMP kinase (AMPK) activity. Moreover, in a recent in vitro study, MF facilitated in the proliferation of MG63 osteoblast like cells. Thus, their action in stimulating bone formation has justified their use in the treatment of perimplantitis.

Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetes mellitus patients.
* Patients with peri-implantitis

Exclusion Criteria:

* History of any other systemic diseases
* Cigarette smokers
* Smokeless tobacco users
* Patients who underwent scaling in the last 1 year
* Patients who took antibiotics in tje past 6 months
Attention Deficit Hyperactivity Disorder

The ADA cohort aims for the systematic and standardized collection of sociodemographic, clinical and neuropsychological data, during 2 visits (inclusion and 12 months), from patients suffering from the co-occurrence of ADHD (Attention Deficit Hyperactivity Disorder) and addiction(s), in addition to the treatment as usual adapted to each situation.

Information on the study and diagnosis of ADHD will be carried out during a medical evaluation consultation, as part of routine care.

The two research visits (inclusion and at 12 months) will be added by the research and will each include:

* A structured clinical interview with a research professional (traceability of oral consent, administration of structured interviews, collection of self-questionnaires, collection of care from the medical record)
* A neuropsychological assessment with a neuropsychologist

Eligibility Criteria:
Inclusion Criteria :

* Patients aged over 15 years and 3 months
* For whom a diagnosis of ADHD has been confirmed less than 6 weeks ago
* For whom the diagnosis of one or more addictive disorder(s) (substance use disorder or behavioral addiction) has been confirmed
* Meeting the indication for treatment with MPH according to European recommendations (Kooij et al., 2019)
* For patients who can actually benefit from MPH: who have not yet started taking MPH
* Social security affiliates

Exclusion Criteria :

* Presenting disorders of higher cognitive functions (at the discretion of the referring clinician or the investigator making the inclusion), making data collection impossible
* Presenting difficulties in reading or writing the French language making data collection impossible
* Unable to commit to being available for the 2 visits planned as part of the cohort
* Under guardianship or legal protection
A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B

CR-HepB registry started in June 30,2012 to collect HBV cases from general hospitals or specialized hospitals for infectious diseases in mainland China. Demographics, diagnosis, laboratory test results, family history and prescriptions were recorded. The main criteria for registration is HBsAg-positivity more than 6 months, and these patients will receive followed-up visits every three to six months.

This web-based database was launched on June 30, 2012 and consists of tertiary or secondary hospitals with special interest and expertise on managing hepatitis B patients across mainland China. The main inclusion criteria for this registration are HBsAg-positivity ≥ 6 months, HBeAg positive or negative, with or without cirrhosis, either treatment-naïve or treatment experienced. At the first time of data entry, demographics, medical history, virology, biochemistry and hematology results, radiology reports, diagnosis and treatment information were recorded. Then the registered patients received standard of care and follow-up every 3 to 6 months. On each visit, virological, biochemical, and radiological reports, as well as clinical progress were recorded.

Eligibility Criteria:
Inclusion Criteria:

* HBsAg-positivity over a continuous six months.

The core exclusion criteria are: 1) HCC patients for their treatment mainly depends on surgical operation and interventional therapy, but not the antiviral therapy; 2) patients who are unable or unwilling to provide informed consent.
Changes in QoL and Symptoms in Patients With Polycythemia Vera Receiving Ruxo in a Routine Clinical Practice

The purpose of this multicenter observational prospective cohort study is to examine changes in QoL and symptoms in patients with polycythemia vera (PV) during treatment with ruxolitinib (Ruxo), and to evaluate efficacy and safety of Ruxo in a real-world setting


Eligibility Criteria:
Inclusion Criteria:

* Patients who have confirmed diagnosis of PV
* Patients whose age - 18 years and older
* Patients who signed informed consent
* Patients who able to fill out questionnaires

Exclusion Criteria:

* Patients enrolled in clinical trials
* Patients with contraindications to Ruxo in accordance with instruction for use
Impact of the PREEMI Package on Neonatal Mortality

The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. In order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care.

The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. In order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care.

The study will provide evidence of implementing a package of clinical interventions coupled with quality improvement and monitoring strategy aimed at reducing neonatal mortality in 3 resource-limited health facilities, leveraging on an existing strengthened birth registry to provide neonatal outcomes up to 28 days after delivery. Additionally, using a multifaceted approach through an interdisciplinary team, the investigators will identify the social and cultural barriers that contribute to home-based deliveries. These findings will be helpful to the Ministry of Health in shaping future policies regarding the scale-up of newborn care clinical protocols as part of Government's efforts to reducing neonatal mortality in Zambia.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women who seek Antenatal care services and plan to deliver in the selected health facilities
* Women who reside within the larger catchment area of the selected 3 health facilities

Exclusion Criteria:

* Women who reside outside the larger catchment area of the health facilities
* Women who have not sought antenatal care services in the 3 health facilities and have come to only deliver there
HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness

The circadian rhythm characteristics of sleep cycle and neuroendocrine in patients with chronic disorder of consciousness show different degrees of disorder, and the relationship between this disorder and consciousness level is unclear.The researchers used HD-tDCS to treat patients with chronic disturbance of consciousness who intervened in circadian rhythm, and used a variety of methods such as EEG, fMRI, protein metabolism, ERP and micro-expression to explore the mechanism of improving the state of consciousness of HD-DCS and the relationship between circadian rhythm and patients' consciousness level

The sleep status (\> 24 hours) of patients with chronic disturbance of consciousness was recorded with the revised coma recovery scale revised (CRS-R) and Polysomnography (PSG). The sleep cycle of patients with chronic disturbance of consciousness was judged by the open and close eyes cycle and EEG.

Patients with circadian rhythm treated with or without blue light stimulation and melatonin were treated with HD-tDCS. EEG, fMRI, protein metabolism, ERP and micro expression data were recorded before and after treatment.Explore the mechanism of improving the state of consciousness of HD-DCS and the relationship between circadian rhythm and patients' consciousness level

Eligibility Criteria:
Inclusion Criteria:

* Patients with diagnosis of disorder of consciousness
* Stable vital signs
* Good coordination, less spontaneous activity
* No anti-epileptic and sedative drugs taken within prior 24 hours
* The family members volunteered and signed the informed consent

Exclusion Criteria:

* locked-in syndrome
* Diseases and factors that may affect the judgment of brain function, such as metabolic diseases, poisoning, shock, etc.
* There are contraindications to MRI scanning, such as the presence of metal implants in the body
* Contraindications treated by transcranial direct current stimulation
The Effect of Phosphorus on Diet Induced Thermogenesis

The aim of the trial is to investigate the effect of ingestion of 75g of glucose (with or without phosphorus) on diet induced thermogenesis (using indirect calorimetry) and appetite (using visual analogue scales) in lean and obese healthy subjects


Eligibility Criteria:
Inclusion Criteria:

* Healthy
* Sedentary lifestyle
* Stable weight for the past 3 months
* On a balanced diet

Exclusion Criteria:

* Underweight (BMI\<18.5) or overweight/obese (BMI≥25)
* age \<18 or \> 30 years
* Inability to give valid consent
* Presence of a chronic or acute illness.
* Elevated physical activity level (assesses by the physical activity questionnaire)
* Heavy smokers (≥1 pack per day).
* Weight gain or loss of \> 3% in the past 3 months
* History of kidney stones
Novel Bioactive Sleeve on Pain and PROMs

A novel bioactive sleeve will be compared to a placebo sleeve with a similar look and feel to assess pain outcomes, patient reported outcome measures, and effectiveness of healing based on range of motion.

This is a blinded randomized prospective study comparing two postoperative leg sleeves. The novel bioactive sleeve (Reparel Leg Sleeve) will be compared to a regular black sleeve with a similar feel/compression. The main hypothesis for this study is that postoperative use of a novel bioactive sleeve after partial arthroscopic meniscectomy/meniscus repair will decrease pain and improve patient reported outcome scores faster and more reliably than the control non-bioactive sleeve. In order to test this hypothesis, approximately 100 patients scheduled for meniscectomy/meniscus repair will be randomized to one of the two arms in order to minimize bias. The following variables will be assessed: patient reported outcomes (VAS, KOOS JR, VR12, and KSS Satisfaction), physical therapy time, motor testing. Each patient will fill out a series of PROMs preoperatively, and post operatively at the 1-week, 2-week, 6-week, 3-month, 6-month, 1 year, and 2-year mark.

Eligibility Criteria:
Inclusion Criteria:

* Provision of signed and dated informed consent form
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Male or female, over the age of 18, undergoing a meniscectomy or meniscus repair
* In good general health as evidenced by medical history
* Under 45th percentile BMI
* Willing to adhere to the study intervention regimenregimen.
* Kellgren-Lawrence grade 2 or less

Exclusion Criteria:

* Febrile illness within 3 months
* BMI over 40
* Treatment with another investigational drug or other intervention within 6 months
* Kellgren-Lawrence grade 3 or more or 4
* History of autoimmune disease, circulatory disease, or vascular disorder
TPTNS for Treating Patients With Premature Ejaculation

Background: Transcutaneous posterior tibial nerve stimulation is an effective therapy for controlling urinary incontinence. Premature ejaculation (PE) and urinary incontinence are anatomically and physio-pathologically similar. Based on this, the use of this therapy is considered to be viable for the control of PE.

Objective: To evaluate the efficacy of transcutaneous posterior tibial nerve electrostimulation for the ejaculatory reflex.

Patients and Methods: Phase II clinical trial. Patients with a diagnosis of premature ejaculation who are treated at the Colombia Boston Medical Group clinic will be included. The participants will receive 3 transcutaneous posterior tibial nerve stimulation therapies per week for 12 weeks. The IELT (Intravaginal ejaculatory latency time) and the PEDT (Premature Ejaculatory Diagnosis Tool) scale will be evaluated on week 6, at the end of treatment, and three months after completing the protocol.


Eligibility Criteria:
Inclusion Criteria:

* Over 18 years of age and less than 50 years of age with no cardiovascular risk factor other than age.
* Having been diagnosed with primary premature ejaculation according to the American Psychiatric Society's Diagnostic and Statistical Manual.
* Agreeing to participate and providing signed informed consent.
* Stable relationship for over 6 months, with frequent intercourse at least once per week.

Exclusion Criteria:

* Diagnosis of erectile dysfunction according to the International Index Function Erectile (IIFE-5) (score under 21).
* A premature ejaculatory diagnosis tool (PEDT) score under 8.
* Use of treatment for premature ejaculation during the study or over the 6 months prior to beginning the study.
* Use of pacemaker or heart defibrillator.
* Epilepsy or convulsions
* Venous insufficiency (varices) or cutaneous wounds or injuries on the lower extremities.
* Congenital or acquired anatomical abnormalities of the penis.
* Taking medications that affect ejaculation control, including psychiatric medications, opioid analgesics, and medications for pathologies of the prostate such as alpha-blockers.
* Psychological or psychiatric disorders that prevent the patient from undergoing the treatment or recording the measurements as established.
* Difficulty going to the clinic 3 times per week as required by the protocol.
* Patients with pre-coital premature ejaculation.
* Use of barrier contraceptive methods or local anesthetics.
The Effects of Different Methods Used in Pediatric Oral Drug Administration

The aim of this study is to determine the effect of the use of spoons and oral injectors on the level of fear in children with fever in oral medication administration.

Fever is known as a defense mechanism of the body; Increased body temperature in children is one of the symptoms that frighten parents and is among the most common reasons for hospitalization. Pharmacological agents such as paracetamol and ibuprofen are often used in fever management, and if possible, oral administration of the suspension form of the drugs is preferred to reduce invasive practices. However, reasons such as children not liking the taste of the medicine, rejecting the medicine, or spitting or vomiting may cause difficulties in administering the medicine orally. More than one different method is used to administer these drugs, depending on the patient's age, general condition and compliance with the treatment. These; They can be listed as spoon, oral injector, medicine glass. As a result of the examination of the drug administration materials, it was stated that children are fear of the injector when the drugs are given with a injector, they may aspirate, and they do not have appropriate equipment to administer the drug. It is important for nurses to understand children's fears and their causes, to develop interventions to reduce fear, and to minimize possible traumatic effects during the hospitilization process.

In this study, the sample will be divided into two groups: experimental and control, and oral antipyretic medicine will be given by two different methods. An oral injector will be used in the experimental group and an oral medicine spoon will be used in the control group.

Hypotheses of the Study:

H0: There is no significant difference in the effect of the use of spoons and oral injectors in oral medication administration in children on the level of fear in children and parents.

H1: There is a significant difference in the fear level of using spoons and oral injectors in oral medication administration in children.

H2: There is a significant difference in the parents' fear level of using spoons and oral injectors in oral medication administration in children.

H3: There is a significant difference in the heart rate and oxygen saturation of children using spoons and oral injectors for oral medication administration.

Eligibility Criteria:
Inclusion Criteria:

* Children aged 3-6 and their parents,
* Children with fever,
* Children who have been ordered to take oral medication for fever in their treatment,
* Able to express himself cognitively,
* Able to speak and understand Turkish

Exclusion Criteria:

* Children who have a disease that may prevent them from expressing their fear
* It is time for the child to sleep at the time of medication administration.