cyrilzakka/clinical-trials huggingface dataset:
Small-sided Ball Game Training and Protein Intake in Older Adults

The effect of small-sided team sport training and protein intake on muscle mass, physical function, and adaptations important for health in untrained older adults was examined. Forty-eight untrained older (72±6 years) men and women were divided into either a team sport group ingesting a drink high in protein (18 g) immediately and 3 h after each training session (TS-HP, n=13), a team sport group ingesting an isocaloric drink with low protein content (3 g; TS-LP, n=18), and a control group continuing their normal activities (CON, n=17).


Eligibility Criteria:
Inclusion Criteria:

* adults aged 65 years or older

Exclusion Criteria:

* severe cardiovascular or neurological disease and participation in regular intense exercise training or sports
Hospital for Special Surgery Hip Arthroplasty Cohort

Total joint replacements are some of the most successful medical devices developed over the last fifty years. They enable millions of people to remain ambulatory and pain free, with minimal risk. In 2002, over 200,000 total hip replacements, 350,000 total knee replacements, and 25,000 total or partial shoulder replacements were performed in the United States (HCUP data). Future use will likely be even higher: it is estimated that by the year 2020, the population 65 and over in developed countries will increase by 71%. Existing studies do not provide adequate prospective data to evaluate long-term outcomes. Most health related quality of life studies in THA and TKA only report data up to twelve months post-operatively. In addition, most large studies of TKA and THA have been performed in Medicare patients. While these databases are important in providing population based data, Medicare studies do not permit any direct patient contact, and provide no information on patients under 65.

Existing studies have also investigated predictors of patient outcome at one and two years after joint arthroplasty. However, very little is known about predictors of prosthesis failure, and there are no validated clinical indicators for choosing one prosthesis model over another. Once a device is FDA approved, there is very little motivation on the part of the developer to perform complete post-marketing research, despite the importance of these data to the public health. Most existent studies are not powered to compare differences between models.

The purpose of this study is to establish a prospective cohort of HSS total hip arthroplasty.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or older
* Undergoing total knee arthroplasty at HSS
* Pregnant women are eligible for the registry as this is a non-interventional study which only involves filling out questionnaires.

Exclusion Criteria:

* No other exclusion criteria;this is a non-interventional study which only involves filling out questionnaires.
Peri-implant Conditions Mimic Periodontal Conditions

Except for patients with referred clinical bruxism and uncontrolled medical conditions, the study included 123 implants with implanted fixed prostheses that had lasted at least six months after functional prosthetic loading. In all implant patients, the health scale ranged from implants and natural teeth to plaque, gingival index, bleeding in the probe, mouth depth, loss of clinical attachment, and dental implants. The health and illness of the implants have been determined. Patients were divided into three groups: peri-implantitis, peri-implant mucositis, and peri-implant health.

Inclusion Criteria:

* Patients between the ages of 18- 70
* Drugs that have a systemically healthy and controlled treatment situation
* Drivers who have implant-supported fixed prostheses that have been at least six months after functional prosthetic loading Among these groups, it was checked whether periodontitis was seen in patients with peri-implantitis, gingivitis in patients with peri-implant mucositis, and whether healthy gums were seen in individuals with peri-implant health.

To determine the health and disease status of individuals' implants, plaque index (Silness Loe 1964), gingival index (Loe Silness 1963), bleeding on probing (Ainoma Bay 1975), pocket depth measurements, and clinical attachment level were collected.


Eligibility Criteria:
Inclusion Criteria:

* Patients between the ages of 18- 70
* Drugs that have a systemically healthy and controlled treatment situation
* Drivers who have implant-supported fixed prostheses that have been at least six months after functional prosthetic loading

Exclusion Criteria:

* Bruxism
* Uncontrolled medical conditions
Relationship Between PFTs and Pdi in DMD

A cross-sectional study to explore the relationship between clinically assessed pulmonary function test (PFT) measures and transdiaphragmatic (Pdi) measures in Duchenne muscular dystrophy (DMD) as well as to explore the relationship between sniff nasal inspiratory pressure (SNIP) and transdiaphragmatic (Pdi) measures in Duchenne muscular dystrophy.

Two small balloons, which are attached to small, flexible tubes, will be put into the esophagus and stomach through your nose. Each balloon is about 2 inches long (deflated) and about the width of a pencil tip. To reduce any discomfort with this procedure, lidocaine gel or spray will be put into the subject's nose and administered to the back of the throat before the balloon. In addition, swallowing water during the procedure will help to reduce any gagging sensation and will assure that the balloon goes into the esophagus. Proper placement of the catheters will be determined using normal tidal breathing against an occluded mouthpiece with a nose clip. Once proper placement is ensured, the catheters will remain in place during your normal PFT maneuvers. Additionally, while the gastric and esophageal balloon catheters are in place, the subject will be asked to perform a maximal sniff maneuver (SNIP) while one nostril is occluded with a plug containing a distal pressure measurement catheter to measure airway pressure. The distal end of the pressure catheter will be connected to a hand held pressure meter to display peak pressure and to provide you visual feedback. This maneuver will be performed 10 times.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of Duchenne muscular dystrophy

Exclusion Criteria:

* Inability to follow verbal instructions
Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome

This is a multicenter genetic study aimed at identifying new genes/variants associated with sudden infant death syndrome (SIDS) based on whole-genome sequencing of family trios

The present project is part of a more global project called BIOMINRISK for which 3 axes will be explored: Genetics (a project which will be detailed here), Neurobiology and Radio-anatomical.

This is a multicenter (15 centers), national, non-randomized, open-label, genetic study. Sudden unexpected death in infant (SUDI) cases will be included (i) partly retrospectively (infants already included in the national French SUDI registry) and (ii) for the other cases, prospectively at the time of care of the deceased infant by the referral center of SUDI participating in the project. The parents making up the trios will be included prospectively.

Once the Sudden infant death syndrome (SIDS) cases have been identified among all the included SUDI cases (following the results of post-mortem examinations), Whole Genome Sequencing (WGS) will be carried out on these SIDS cases and their two parents, in order to identify pathogenic allelic variants. The data generated by this sequencing will then be analyzed using a trio approach to search for de novo variants, i.e. variants present in the infant who died of SIDS and absent from the genome of both parents.

Eligibility Criteria:
Child Inclusion Criteria

* Death of a child between 0 and 2 years of age due to sudden unexpected death in infant
* Child included in the French SUDI registry with effective participation in the biocollection
* Children who also meet the inclusion criteria for the BIOMINRISK-NEUROBIO (axis 2) and BIOMINRISK-RADIO-ANAT (axis 3) studies in the overall BIOMINRISK project.

Parents Inclusion Criteria

* Biological parents of the child included in the BIOMINRISK study
* Parents who have both signed the consent form for blood collection and inclusion of their samples in the biocollection
* parents beneficiaries of a social security or similar scheme

Child Exclusion Criteria:

* Presence of a known metabolic, genetic or syndromic pathology at the time of death

Parents Exclusion Crtiteria:

* Parent under guardianship
* Presence of a known metabolic, genetic or syndromic pathology
Egg White for Phosphorus Control in Haemodialysis Patients

To evaluate the effect on phosphatemia in hemodialysis patients of replacing the meat or fish included in two meals a week with an amount of egg white containing the same quantity of proteins.

Hyperphosphatemia develops in the majority of patients with end-stage renal disease (ESRD). It is responsible for severe complications such as mineral bone disease, and has a role in worsening the cardiovascular mortality of dialyzed patients. Therefore, a close control of serum phosphorus remains a cornerstone in the clinical management of dialyzed patients to improve their long term prognosis. There are multiple sources of phosphorus in the diet that could be the target of such a dietary intervention but, because of important differences in bioavailability, they are not all equally relevant in influencing phosphatemia. Among them animal proteins that have a bioavailability of about 60% represent an important target for phosphate-lowering nutritional interventions. However, lowering the protein content of the diet in hemodialysis (HD) patients may be dangerous because it may increase the the risk of malnutrition hence worsening their prognosis. In the present study we intend to explore an alternative strategy to lower the intake of phosphate with animal proteins by replacing the meat or fish included in two meals a week with egg white that is reach of proteins but has virtually no phosphate.

Eligibility Criteria:
Inclusion Criteria:

* thrice weekly 4 h standard bicarbonate HD treatment with an at least 6-month vintage
* stable dialysis dose and modality at least by 3 months
* hyperphosphataemia (serum phosphate ≥5.0 mg/dl) at least by 3 months
* stable dietary intake at least by 3 months
* stable body weight at least by 3 months
* stable biochemical markers at least by 3 months

Exclusion Criteria:

* diabetes
* liver disease
* malignancy
* previous parathyroidectomy
* psychiatric diseases
* non-collaborative patients
Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma

The purpose of this study is to determine the response rate and overall survival in patients that have been diagnosed with mesothelioma and will undergo chemotherapy, surgery and intensity modified radiation therapy (IMRT) as part of their standard of care.

The investigators will consent patients that have been diagnosed with mesothelioma and will undergo chemotherapy followed by surgery and then IMRT as their standard of care. The investigators will collect data from past and future medical records as well as data regarding their health status for their lifetime by reviewing life status, treatment status and CT scans.

Eligibility Criteria:
Inclusion Criteria:

* Subject provides informed consent
* Subject is \>18 years of age
* Subject is deemed competent for making medical decisions
* Subject is scheduled to undergo chemotherapy followed by surgery and then IMRT
* Subject is a surgical candidate
* A negative pregnancy test is required in women of child-bearing potential, as standard of care.

Exclusion Criteria:

•Subject is \<18 years old.
Role of Anesthesiologist-Patient Relationship

Descriptive analytic survey of 1137 and 518 patients aged 16 years or more before and after anesthesia exposure, respectively to assess the anesthesiologist-patient relationship role on patient postoperative perception of the binominal anesthesia-anesthesiologist. The aim of this study was to assess the anesthesiologist-patient relationship role on patient postoperative perception of the binominal anesthesia-anesthesiologist.

Period: may/2007 to may/2008

A questionnaire was used to determine patient characteristics and perception of anesthesia/anesthesiologist, as well as fears and concerns related to anesthesia. This descriptive-analytic study was based on opinions and information provided before and after anesthesia by individuals who were hospitalized in the Botucatu Medical School (BMS) Hospital to undergo surgery under anesthesia administered by the Anesthesiology Service of BMS Department of Anesthesiology. A questionnaire including structured questions aimed at determining patient characteristics (age, gender, race, marital status, education level, birthplace, provenance, surgical service of origin, occupation, history of anesthesia exposure) and perceptions of anesthesiologists/anesthesia, as well as open-ended questions that allowed respondents to add free comments, recorded as spoken, about their concerns before and after anesthesia. The post-anesthesia interview also included questions regarding the administration of pre-anesthetic drugs, recall of the anesthesiologist in the operating room, satisfaction with the care provided by the anesthesiologist.

Eligibility Criteria:
Inclusion Criteria:

* conscious surgical patients
* 16 years or more
* Portuguese-speaking patients

Exclusion Criteria:

* patients with altered states of consciousness or expression/comprehension impairment
* patients who did not undergo anesthesia/surgery (cancelled or postponed)
Statin Therapy in Acute Influenza

Influenza (the 'flu') is a common virus infecting approximately 5-20% of the population in the United States and causing as many as 500,000 deaths worldwide each year. Currently, there are only a few treatments for influenza infection and none of these target inflammation that can be caused by the virus. This study will test whether the anti-inflammatory effects of statins, a class of drugs most often used to treat high cholesterol, will decrease the severity of illness in patients who are infected with influenza by testing markers of inflammation in the blood and recording resolution of influenza illness.


Eligibility Criteria:
Inclusion Criteria:(all must be present):

1. Adult patient (age \> 18 years)
2. Positive influenza DFA/RAT test result
3. \<12 hours from positive influenza test result

Exclusion Criteria:

1. Prior statin medication use (within 30 days of positive influenza test result)
2. Comfort measures only designation or anticipated withdrawal of life-support
3. Atorvastatin specific exclusions:

   1. Documented liver cirrhosis or liver dysfunction (AST or ALT greater than 240)
   2. Known allergy or intolerance to statins
   3. Rhabdomyolysis (CPK elevation \> 6x normal)
   4. Patients taking the following medications: cyclosporine, HIV protease inhibitors, hepatitis C protease inhibitor telaprevir, fibric acid derivatives (gemfibrozil), niacin, azole antifungals (itraconazole, ketoconazole) clarithromycin and colchicine
4. Patients unable to take oral or nasogastric medications or plan for no oral intake as part of medical course (eg. emergent surgical intervention)
5. Known pregnancy or active breastfeeding
6. Inability to provide written informed consent for any reason
A Study Comparing Dulaglutide With Insulin Glargine on Glycemic Control in Participants With Type 2 Diabetes (T2D) and Moderate or Severe Chronic Kidney Disease (CKD)

The purpose of this study is to determine the glycemic efficacy and safety of dulaglutide compared to insulin glargine in the treatment of participants with type 2 diabetes and moderate or severe chronic kidney disease.


Eligibility Criteria:
Inclusion Criteria:

* Men and non-pregnant women aged ≥18 years
* Hemoglobin A1c (HbA1c) ≥7.5% and ≤10.5%
* Type 2 diabetes on insulin or insulin + oral antihyperglycemic medication
* Participants with presumed diabetic kidney disease with or without hypertensive nephrosclerosis diagnosed with moderate or severe CKD with estimated glomerular filtration rate (eGFR) of ≥15 to \<60 milliliters per minute (mL/min)/1.73 meter squared (m\^2)
* Able and willing to perform multiple daily injections
* Body mass index (BMI) between 23 and 45 kilogram/square meter (kg/m\^2)

Exclusion Criteria:

* Stage 5 CKD as defined by eGFR \<15 mL/min/1.73 m\^2 OR having required dialysis
* Rapidly progressing renal dysfunction likely to require renal replacement
* History of a transplanted organ
* Type 1 diabetes mellitus
* At screening a systolic blood pressure of ≥150 mmHg or a diastolic blood pressure of ≥90 mmHg with or without antihypertensive medication
* An episode of ketoacidosis or hyperosmolar state/coma in the past 6 months or a history of severe hypoglycemia in the past 3 months prior to the Screening Visit
* Cardiovascular conditions within 12 weeks prior to randomization: acute myocardial infarction, New York Heart Association (NYHA) class III or class IV heart failure, or cerebrovascular accident (stroke)
* Acute or chronic hepatitis
* Signs and symptoms of chronic or acute pancreatitis, or were in the past diagnosed with pancreatitis
* Serum calcitonin ≥35 picograms per milliliter (pg/mL) at Screening Visit
* Self or family history of medullary C-cell hyperplasia, focal hyperplasia, or carcinoma
* Known history of untreated proliferative retinopathy
Sustainable Eating Behaviors and Diet Quality

The goal of this observational study is to evaluate the sustainable nutrition behaviors (e.g. not wasting food, consuming organic food) and diet quality of university staff. The main questions it aims to answer are:

* What is the diet quality of the participants?
* Do participants with higher diet quality have better sustainable eating behaviors?

Sustainable diets are diets with low environmental impacts that contribute to food and nutritional security and healthy living for present and future generations. They are recognized as protective of ecosystems, culturally acceptable, accessible, economically fair and affordable, nutritionally adequate, safe and healthy diets. Sustainable healthy diets ensure optimal growth and development of all individuals, support functionality across all life stages for current and future generations, contribute to the prevention of all forms of malnutrition, reduce the risk of diet-related non-communicable diseases and support the protection of biodiversity and planetary health. Recently, the need to promote nutritious and safe sustainable diets with low environmental impact has been emphasized. Diets based mostly on plant-based foods, such as the Mediterranean diet and the DASH diet, are recognized as sustainable eating models. The aim of this study is to evaluate the sustainable eating behaviors and diet quality based on food consumption of academic and administrative staff working at the university and to determine the relationship between them.

1. How is the diet quality of the university staff?
2. How are the sustainable nutrition behaviors of the university staff?
3. Is there a difference between diet quality groups in terms of sustainable nutrition behaviors?

Eligibility Criteria:
Inclusion Criteria:

* Being a staff member of Tarsus University
* Volunteering to participate in the study

Exclusion Criteria:

* Pregnancy
* The presence of any known condition that prevents the taking of anthropometric measurements
* Presence of a known memory problem that may prevent receiving 24-hour Recall
Comparative Effects of Nebivolol and Carvedilol on Diastolic Function in the Elderly Heart Failure Patients

Heart failure (HF) is a common and disabling condition in the elderly. Randomized clinical trials and meta-analyses have clearly demonstrated that long-term use of β blockers improves the outcomes of patients with HF. However, limited data have been available on the treatment of HF with preserved ejection fraction (EF) in the elderly. No study has specifically compared the relative effectiveness of carvedilol and nebivolol in treating HF in old age patients with preserved EF.

This trial is a prospective, randomized, open-label, active controlled study designed to investigate effects of nebivolol and carvedilol on diastolic function of the left ventricle (LV) in the elderly HF patients with preserved EF.

Patients will be included in the study if they had LVEF ≥ 40%, NYHA functional class I, II or III, and clinical stability without hospital admission for HF in the preceding 3 months.

Eligibility Criteria:
Inclusion Criteria:

* more than 70 years
* EF ≥ 40%

Exclusion Criteria:

* contraindication to the study drug
Endostar Combination With Chemotherapy for the Metastatic Nasopharyngeal Carcinoma

The investigators designed this study to evaluate the efficiency and the acute toxicities of recombinant human endostatin (endostar) combined with chemotherapy in the metastatic nasopharyngeal carcinoma (NPC).

To evaluate the progression free survival (PFS), overall survival (OS), Acute adverse reaction of recombinant human endostatin (endostar) combined with chemotherapy to the metastatic nasopharyngeal carcinoma (NPC).

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed metastatic NPC patient who have received radiotherapy or chemoradiotherapy with an at least 6 months interval
* Have measurable lesions
* No dysfunction of the major organs
* Can understand this study and give a signed informed consent certificates
* without a history of allergic reaction to the biological agents

Exclusion Criteria:

* Pregnant or lactating women; Women of child-bearing age without contraception
* with a Serious infection or dysfunction of the major organs
* have taken other antitumor drugs during the period of 30 days ahead of this clinical trial
* allergic to the Escherichia coli preparations
* Cann't understand this study and give a signed informed consent certificates
The Value of Three Dimensional Echocardiography in Congenital Cardiac Surgery

There are few studies evaluating the value of 3D echocardiography in children undergoing congenital cardiac surgery. The aim of this observational study is to describe common and uncommon congenital malformations with the help of 3D echo and compare the findings and the measurements with those obtained with conventional 2D echo.


Eligibility Criteria:
Inclusion Criteria:

* All children requiring general anesthesia for congenital heart surgery and in whom informed parental consent has been obtained

Exclusion Criteria:

* Children with congenital heart disease who do not require heart surgery