cyrilzakka/clinical-trials huggingface dataset:
Iron Deficiency Anemia Among Chinese Pregnant Women: a Multi-center Prospective Cohort Study

Iron deficiency anemia during pregnancy, which may lead to adverse pregnancy outcomes, was a serious health problem in China. Various iron supplements used in different regions of China, however, the effects have not been well investigated. The objective of this study is to investigate the diagnosis, treatment and prognosis of iron deficiency and iron deficiency anemia in Chinese pregnant women.

This is a nationwide multicenter prospective cohort study conducted in seven hospitals in China to investigate the diagnosis, treatment and prognosis of iron deficiency and iron deficiency anemia in Chinese pregnant women. This study will enroll about 6000-7000 pregnant women, who established a health record in the seven hospitals. Demographic characteristics, laboratory tests, behavior habits during pregnancy, mental status, and pregnancy outcomes will been collected. All information will collect by a pregnant women self-reported questionnaire and the electronic medical record system in hospitals at three timing points: 6-15 gestational weeks, 30-34 gestational weeks and one week after delivery.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women who registered an antenatal care file at the survey hospital ;
* Signed informed consent.

Exclusion Criteria:

* Participated in any drug or nutritional clinical trial from 3 months before pregnancy to recruitment.
Protocol of Virtual Interactive Memory-Training Program

This study sought to investigate the changes in objective memory performance (including immediate recall and delayed recall), subjective memory complaints and degree of depression in older adults with mild cognitive impairment after Virtual interactive memory training (VIMT).

This double-blind randomized controlled study has a 2-arm parallel group design. All subjects will be randomized by the block randomization, into intervention group (Virtual interactive memory training, VIMT), or active control group (Passive information activities, PIA). Training sessions of the VIMT group are 45 minutes/day, 3 days/week, for 12 weeks (36 sessions each). The training of PIA group is the same as VIMT group. We constructed a rigorous VIMT program adhering to the Consolidated Standards of Reporting Trials (CONSORT) reporting guidelines. The investigators expect to determine the improvement in memory function and degree of depression of older adults with mild cognitive impairment after using the VIMT.

Eligibility Criteria:
Inclusion Criteria:

1. Participants must endorse at least two items from a list of frequent subjective memory complaints by patient and/or an informant
2. Objective memory impairment on neuropsychological tests of memory 1.5 SD or more below age/education norms
3. Clinical neurologic examination by the Mini-Mental State Examination (MMSE) score of 24 or higher, and cut-off score of 23/24 on the Montreal Cognitive Assessment (MoCA)
4. No impairment in personal activities of daily living (P-ADL) as determined by clinical interview with participant and family

Exclusion Criteria:

1. The clinical diagnosis of dementia was based on the DSM-IV-TR
2. Active in another cognitive or memory-related training in the past year
3. Comorbid medical conditions that would predispose them to imminent functional decline or cognitive impairment
4. A diagnosis of major neurological or psychiatric illness history and/or behavioral problems that would sufficiently impair performance to make participation impossible
5. Severe losses in vision, hearing, or communicative ability
Intravenous Treatment of Anemia in Pregnancy

The investigators assess and compare the efficacy of anemia treatment in pregnant women with anemia of chronic disease with true iron deficiency and in women with iron deficiency anemia.

Fifty anemic pregnant women with moderate anemia were prospectively observed and treated in the Anemia clinic at the Department of Obstetrics, University Hospital Zurich. All patients had singleton pregnancies. All pregnant women fulfilled criteria of moderate iron deficiency anemia defined as hemoglobin (Hb) between 8.0 and 9.9 g/dl and serum ferritin \<15 μg/l. In all women, the analyses of a blood count, iron status, erythropoietin, cross reactive protein (CRP), folic acid and vitamin B12 were conducted. According to hemoglobin level at the start of the therapy, the women were either treated with intravenous iron and rhEPO or with intravenous iron only twice weekly. Patients with an Hb level between 9.0 and 9.9 g/dl (33 patients) received 200 mg iron sucrose (VENOFER®, Vifor Int., St. Gallen, Switzerland) intravenously twice weekly (group A). If response to therapy was poor (i.e. Hb increase \<0.7 g/dl) after 2 weeks (13 patients), patients additionally received rhEPO (10,000 U EPREX®, Janssen-Cilag, Baar, Switzerland) (group B). This cut-off for adequate primary response the investigators choose on the basis of previous experience. Patients with an Hb between 8.0 and 8.9 g/dl (17 patients) received iron sucrose (Venofer) and rhEPO (Eprex) twice weekly from the start of therapy (group C).

Sufficient overall response to therapy (the difference of baseline hemoglobin and after therapy) was defined as Hb increase \>1.0 g/dl. The maximum total iron dose was 1,600 mg, therefore therapy was stopped if the maximal iron sucrose dose was administered, or target Hb \> 10.5 g/dL was achieved.

Eligibility Criteria:
Inclusion Criteria:

* pregnant women with hemoglobin between 8.0 and 9.9 g/dl and serum ferritin \<15 μg/l

Exclusion Criteria:

* vitamin B12 deficiency anemia
* folic acid deficiency anemia
* hemoglobinopathy
* multiples
* liver disease
* kidney disease
Chiropractic Force Versus Touch

The Life University Center for Chiropractic Research is conducting a research study to better understand the physiologic and brain-based differences between the touch and force components of the chiropractic adjustment. Eligible individuals will either receive a chiropractic adjustment with force or a non-force stimulation. Individuals in the force stimulation group will receive an active spinal adjustment with a handheld instrument called an Activator. Individuals in the non-force stimulation group will have one Activator placed on the spine and another Activator clicked away from the spine. This study is not randomized. The first participant will receive an active spinal adjustment, and the second participant will receive a non-force stimulation at the same locations as the first participant. This pattern repeats until all individuals have been recruited (n=30). Outcome assessments include resting state electroencephalography (EEG), electrocardiography (ECG), and blood pressure. Outcome assessments will be captured prior to the adjustment or non-force stimulation, after the adjustment or non-force stimulation, and one week later. Individuals will also undergo a standard health history and chiropractic physical exam at the start of participation.


Eligibility Criteria:
Inclusion Criteria:

* You are between the age of 18 and 50.
* You have not had a chiropractic adjustment in the past 2 weeks.
* You are not currently receiving care such as acupuncture or physical therapy.
* You are currently not taking any medication that may change your brain patterns.

Exclusion Criteria:

* You do not have a history of recent spinal surgery or trauma.
* You do not have any other health conditions that may prevent you from receive chiropractic care. This could include diagnosed osteoporosis.
* You are not pregnant.
* You do not have a severe mental health condition.
* You do not have a known heart condition.
RoboHear™ Device: Advanced Haptic Technology That Allows the Deaf to Understand Speech

Pilot study to test the feasibility of translating the English language into haptics (touch sensations)

An adaptive pilot trial of RoboHear™ hardware and software to test the feasibility of learning to understand language using a haptic (touch) device installed in the stem of a pair of glasses. These tests are not meant to be exhaustive but will validate the hardware and software and provide an informal test platform for learning to 'hear' or interpret sounds and words using haptic technology.

Eligibility Criteria:
Inclusion Criteria:

* Participants need to understand English.
* Participants must be able to sit at a computer for the training and evaluation session. The session may range from one hour to up to 4 hours in length (with breaks provided as needed).

Exclusion Criteria:

* Inability to understand English
Brain Stimulation Effects on Cognitive Task Performance

The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.

Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that relies on rapidly changing magnetic fields to influence neuronal firing rates. TMS can be used to temporarily inhibit or enhance the firing of populations of neurons located in the cerebral cortex. TMS-induced cortical inhibition versus enhancement is increasingly being used as a tool for exploring brain-behavior relationships and for improving cognitive functioning in people experiencing cognitive deficits due to neuropsychiatric illness (e.g., dementia and schizophrenia). However, important and unresolved methodological issues in this field concern the optimal design of cognitive tasks for TMS stimulation protocols. The purpose of this study is to determine optimal design protocols for online TMS studies of cognitive processes involved in attention, learning, and memory. Research participants will complete cognitive tasks while active versus sham (i.e., non-stimulating) TMS is applied to the brain. A factorial design will be used to determine the combination of task and TMS parameters (i.e., device settings) that produce the most robust and reliable behavioral effects.

Eligibility Criteria:
Inclusion Criteria:

* Right-handed
* Fluent in English

Exclusion Criteria:

* History of seizures or epilepsy
* Family history of epilepsy
* Significant medical or neurological diagnoses
* History of common headache or migraine
* History of common or recent syncope
* History of moderate/severe, multiple mild, or past 12 months head injury
* History of psychiatric, psychological, or neurodevelopmental disorder
* History of alcohol or recreational drug abuse or dependence
* Current visual or hearing difficulties that interfere with cognitive testing
* History of cochlear implants
* Current pregnancy
* History of metal in the head or neck (except braces and fillings)
* Current non-removable piercings in the neck or head
* History of implanted neurostimulator
* History of cardiac pacemaker or intracardiac lines
* History of medication infusion device
* Current use of medications that increase the excitability of the brain
* History of problems with TMS or MRI procedures
* History of EEG for suspected epilepsy
* Alcohol or recreational drug use in the 48 hours prior to TMS
* Inadequate sleep in the 48 hours prior to TMS
* Headache or feeling faint in the 24 hours prior to TMS.
Tetracaine Combined Spinal Epidural (CSE) Versus Bupivacaine CSE

The investigators hypothesis is that spinal tetracaine with fentanyl and epinephrine used for CSE labor analgesia volume will last a significantly longer period of time that that of spinal bupivacaine with fentanyl. After informed consent is obtained for the study, subjects meeting criteria when analgesia is requested will be randomized to receive a combined spinal-epidural containing either tetracaine 2 mg with fentanyl and epinephrine or bupivacaine 2 mg with fentanyl and epinephrine.


Eligibility Criteria:
Inclusion Criteria:

* early labor (\>=2cm but =\<6cm cervical dilation)
* at least 12 years of age
* have an assigned ASA physical status 1 or 2
* singleton pregnancy

Exclusion Criteria:

* contraindications to neuraxial anesthesia
* with allergies to drugs used in the study
* have an assigned ASA status 3 or 4
* advanced labor (\> 6cm cervical dilation)
* less than 12 years of age
* Patients with the potential for distorted epidural anatomy, such as Harrington rods or prior back surgery, will also be excluded.
Fitness and Longevity in Exercise

The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity.

The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise (AEX) training in older HIV-infected adults. Funding was provided by K23 AG024896 (PI, Oursler) and the UMB Claude D. Pepper Older Americans Independence Center P60 AG12583 (PI, Goldberg).

The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults.

The study met its objectives:

1. Scientific AIMS met:

   1. High-intensity AEX training significantly increases aerobic capacity
   2. Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance.
   3. Activity of skeletal muscle oxidative enzymes is reduced, and associated with aerobic capacity.
2. Feasibility Objectives met:

   1. AEX training is safe and well-tolerated in older HIV-infected adults.
   2. Skeletal muscle punch biopsy is safe and well-tolerated in older HIV-infected adults.
   3. Preliminary data was collected on plasma biomarkers of inflammation.

Eligibility Criteria:
Inclusion Criteria:

* HIV+
* stable combination antiretroviral therapy (cART)

Exclusion Criteria:

* AIDS defining conditions in the prior six months
* Conditions that increase the risk of exercise training per the American College of Sports Medicine (ACSM)
Efficacy of Propolis Varnish Against Oral Biofilm

This study aims to evaluate the effectiveness of a varnish containing 15% of green propolis on Streptococcus mutans in saliva and biofilm. Will be invited to join the study: children 8-10 years old, free of caries, without orthodontic appliances and without having undergone antibiotic therapy until three weeks before the start of the study. Saliva will be collected before, immediately after, 24 hours and 30 days after application of the varnish. The collection of biofilm will be performed before, after, 24 hours and 30 days after application of the varnish. Data will be collected and compared between periods.

Antimicrobials are substances used in dentistry as an efficient way of caries prevention. Substances such as chlorhexidine are the most known and most applied for this purpose and, as a varnish, increased its anticariogenic potential. The antimicrobial effects of natural substances are being studied for exhibiting antimicrobial properties similar to those of chlorhexidine, but less toxic in some cases. Several studies with propolis has proven its efficacy against several microorganisms of the oral cavity, specially Streptococcus mutans. A pharmaceutical formulation containing brazilian green propolis was developed based on the chitosan polymer that is biocompatible and biodegradable. In a previous study, we observed in vitro antimicrobial properties of the varnish against Streptococcus mutans. This work aims to study the preliminary evidence of the efficacy of the propolis dental varnish in reducing Streptococcus mutans in saliva and in the biofilm control through a phase II study involving patients with 8-10 years. After 30 days, the results will be compared and statistically analyzed at a level of significance of 5 % .

Eligibility Criteria:
Inclusion Criteria:

* children 8-10 years old
* good general health condition
* not making use of mouthwashes or medications (especially antibiotics), until three weeks prior to the beginning of the experiment.

Exclusion Criteria:

* Patients in medical treatment or who used drugs (especially antibiotics), in the three previous weeks and patients with active caries lesions.
Arterial to End-Tidal Carbon Dioxide Difference During Pediatric Laparoscopic Surgeries

Studying the arterial to end-tidal carbon dioxide difference in children undergoing laparoscopic surgeries under different intra-abdominal pressures is of extreme importance. This is because both hyper and hypocarbia are detrimental in this vulnerable age group.

Capnography provides a non-invasive estimate of arterial CO2 levels and allows clinicians to modify mechanical ventilation settings in order to maintain normocapnia. Normally, a positive gap between arterial CO2 and ETCO2 of approximately 0.5 kPa is assumed in a healthy patient and ventilation settings are adjusted accordingly. However, the correlation between PaCO2 and PetCO2 during laparoscopic surgery is inconsistent mainly due to inter- and intra-individual variability. Discrepancies between arterial carbon dioxide and End-tidal carbon dioxide measures have been demonstrated in ventilated children with cyanotic congenital heart disease , infants with respiratory failure and during visceral and urological laparoscopic surgery. Moreover, as the increase in PaCO2 is directly proportional to the level of intra-abdominal pressure (IAP) used, variations in the arterial to end-tidal carbon dioxide difference can be also expected with different levels of IAP used.

Eligibility Criteria:
Inclusion Criteria:

* Children with the following inclusion criteria;
* Weight: 10-30 kg.
* Age: 1-6 years.
* Sex: both males and females.
* ASA physical status: I, II.
* Operation: elective laparoscopic surgeries that last more than 45 min.

Exclusion Criteria:

Patients will be excluded if they have;

* Patients with any perioperative cardiovascular or respiratory event occurred which made the study intervention clinically unacceptable,
* Patients with unsatisfactory preoperative peripheral arterial oxygen saturation,
* Patients with unsatisfactory preoperative hemoglobin level, neurological or psychiatric disease,
* Children with a BMI \>95th percentile for age.
Ultrasound-Guided Suprascapular Pulsed Radiofrequency

Shoulder pain is the second most common musculoskeletal disease in adults, and it often becomes chronic due to treatment difficulties.

Pulsed radiofrequency (PRF) therapy has become increasingly popular in the treatment of chronic shoulder pain due to its long duration of action and non-destructive method.

These patients lacked pain control despite systemic analgesics and conservative therapy and applied to our pain polyclinics for shoulder pain lasting at least 3 months.

The ultrasound-guided SSPRF was performed in those patients with a reduction of 50% or more VAS score and those that reported healing in the AROM in the diagnostic SNB.

The resting, motion and sleeping shoulder pain assessments of the patients were done using a visual analog scale (VAS). The shoulder joint function was assessed using the Shoulder Pain and Disability Index (SPADI) questionnaire and the active range of motion (AROM) of the joint was measured using a goniometer In this study, investigators aimed to reveal the effects of ultrasound-guided suprascapular PRF (SSPRF) therapy applied to patients with chronic shoulder pain on both shoulder pain and function.

Eligibility Criteria:
Inclusion Criteria:

Patients 18 years of age or older who were diagnosed with at least one of the following: adhesive capsulitis of the shoulder (M75.0), rotator cuff syndrome (M75.1), and impingement syndrome of shoulder (M75.4) according to the ICD-10 classifications. These patients lacked pain control despite systemic analgesics and conservative therapy (like physiotherapy) and applied to our pain polyclinics for shoulder pain lasting at least 3 months.

Exclusion Criteria:

Patients with other diseases causing chronic pain, those with neuropathic pain, those who had undergone surgery on the same shoulder, those with an allergy history from local anesthesia, those with abnormal coagulation tests, and those with cardiac pacemakers were excluded from this study.
Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes

This trial is conducted in Japan. The trial aims for comparison of the effect on glycaemic control of liraglutide, compared to sulfonylurea (SU treatment), as assessed by HbA1c after 24 and 52 weeks in subjects with type 2 diabetes. Trial has a randomisation period of 24 weeks followed by a 28 week extension period, in total 52 weeks.


Eligibility Criteria:
Inclusion Criteria:

* Type 2 diabetes
* Diet/exercise therapy with or without an oral anti-diabetic drug for at least eight weeks
* HbA1c greater than or equal to 7.0% and less than 10.0%
* BMI (Body Mass Index) less than 35 kg/m2

Exclusion Criteria:

* Treatment with insulin within the last 12 weeks
* Treatment with any drug that could interfere with the glucose level
* Any serious medical condition
* Females who are pregnant, have intention of becoming pregnant or are breastfeeding
Mental Health First Aid for College Students

Most college students with mental disorders do not receive treatment, and over 80% of those who die by suicide have never made contact with campus mental health services. Knowledge, stigma, and other health beliefs represent significant barriers to help-seeking for many of these students. However, there have been no large-scale intervention studies for reducing these barriers to mental health treatment on college campuses. This project will fill this gap by determining whether a community mental health education program, Mental Health First Aid (MHFA), is an effective method to increase number of students who seek mental health services on college campuses. MHFA is an international, 12-hour training program that has been shown to increase knowledge of mental illnesses and their treatments, decrease stigma, and increase helping behaviors in community members. However, it has not been tested in a college setting in the United States. To determine the effectiveness of MHFA in US colleges, the proposed project will involve a randomized control trial of the MHFA training program on 32 campuses representing a range of higher education institutions, from community colleges in rural areas to research universities in large, urban areas. The MHFA training program will be administered to peer supports such as residential advisors. Administrative data from campus mental health services and pre- and post-intervention surveys will be used to collect outcome data on service utilization, knowledge, attitudes, and other measures. Data analyses will focus on identifying changes in students' behaviors, knowledge, and attitudes toward mental illnesses that can be attributed to the MHFA training. In addition to testing a novel and timely mental health intervention for college students, this project will result in improved data collection measures for college populations, and will lay the foundation for stronger connections and future collaborations between diverse campus communities. If the MHFA program is successful in reducing stigma and increasing general on-campus awareness and early treatment of emerging mental health problems, then it may provide a cost-effective means for enabling more students to seek early treatments for developing mental health problems.


Eligibility Criteria:
Inclusion Criteria:

* Student enrolled in a participating campus as a full-time, residential undergraduate during the 2009-2010 or 2010-2011 academic years. Student must have been living in a participating residence hall.

Exclusion Criteria:

* Students under 18 years of age.