cyrilzakka/clinical-trials huggingface dataset:
3 Ultrasound Guided Plane Blocks for Perioperative Analgesia in Patients Undergoing Radical Cystectomy

Radical cystectomy is the gold standard treatment for muscle invasive bladder cancer as well as some T1 and non-invasive disease. It is a major operation with significant perioperative morbidity and complications. Pain is one of the most important complications to be managed.

Regional blocks as a part of multi-modal analgesia are considered main strategies of Enhanced Recovery after Surgery (ERAS) decreasing post-operative complications including post-operative pain and post-operative hospital stay. They also have an upper hand over systemic intravenous opioids decreasing the risk for post-operative delirium specially in old age patients. Thoracic paravertebral plane block (TPVPB), intra muscular quadratus lumborum plane block (QLPB) and erector spinae plane block (ESPB) are among these regional anesthesia techniques for pain management.

Erector spinae plane block is an emerging block, with low risk and more feasibility, but efficacy hasn't been compared to quadratus lumborum and paravertebral plane blocks altogether in radical cystectomy surgeries.

All these blocks are effective in reducing postoperative pain and the need of analgesia in radical cystectomy surgery; this is a comparative study between the three blocks in this population.


Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists (ASA) class II - III.
* Adult patients scheduled for radical cystectomy.

Exclusion Criteria:

* Patient refusal.
* Uncooperative patients.
* Patients with known allergies to local anesthetics.
* Bleeding disorders or coagulopathy.
* Anatomical abnormality or infection at injection site.
* Patients receiving opioids for chronic analgesic therapy.
* Spinal anesthesia or any other regional anesthesia.
Acute Effects of Static Stretching on the Knee Joint Position Sense of Soccer Players

The aim of this study was to investigate the acute effects of static stretching on the knee joint-position sense of soccer players.

This crossover randomized controlled trial included male soccer players. All participants performed 3 conditions: two experimental conditions, of static stretching of the quadriceps and hamstrings muscles, for 30 or 90 seconds; and a control condition (rest). Knee joint-position sense of the dominant limb was assessed before and immediately after the conditions for the range of 45º of knee flexion by active repositioning, using a video camera. Absolute, relative and variable angular errors were calculated.

Eligibility Criteria:
Inclusion Criteria:

* male soccer players
* aged between 18 and 30 years old
* with normal knee range of motion
* without history of lower limb injuries in the last 6 months

Exclusion Criteria:

* history of knee surgery
* with cardiorespiratory, neurological or vestibular diseases
* with positive knee integrity tests (anterior drawer, posterior drawer, Lachman test and valgus and varus stress tests)
* using drugs that could affect the central nervous system, balance, or motor control (sedatives, anxiolytics, analgesics, NSAIDs, muscle relaxants, or antibiotics).
Study of the Safety and Effectiveness of Rabeprazole in Treatment of Helicobacter Pylori Infection in Adults.

The purpose of the study is to confirm the safety and effectiveness of rabeprazole in the treatment of adult patients with Helicobacter pylori (H. pylori) infection in routine clinical practice.

An infection of Helicobacter pylori (H. pylori) is a risk factor for many types of gastrointestinal diseases and associated with stomach inflammation, ulcer of the stomach or small intestine. The recommended treatment for the infection is a triple therapy consisted of one proton pump inhibitor, such as rabeprazole, and two antibiotics administered for 7 days. This is an open label, nonrandomized study of the safety of rabeprazole in the treatment of patients with H. pylori infection. The study consists of 2 phases: the 2-month main phase and the 4-month monitoring phase (total duration of 6 months). During the main phase, patients are treated for 7 days with three drugs (rabeprazole, clarithromycin, and amoxycillin), and the effectiveness of the treatment is assessed 4 weeks later. During the monitoring phase, patients are interviewed at monthly intervals to assess symptoms and to report any adverse events. Safety assessments include the incidence of adverse events throughout the treatment and monitoring phases, and laboratory tests (hematology, biochemistry, urinalysis) and vital signs at the start of the study and after 1 month. Assessments of effectiveness include the eradication of H. pylori infection, assessed by the urea breath test one month after treatment. The primary study hypothesis is that rabeprazole is well-tolerated long-term in the treatment of patients with H. pylori infection in routine clinical practice. Rabeprazole tablets (20 milligrams\[mg\]) taken orally twice daily for 7 days. Clarithromycin (500mg) and amoxycillin (1 gram) taken twice daily for 7 days.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with Helicobacter pylori (H. pylori) infection
* patients over 45 years of age must have an endoscopic examination of the digestive system
* patients must have positive result of urea breath test (UBT) for H. pylori
* patients being treated with rabeprazole in combination with clarithromycin and amoxycillin to eradicate H. pylori.

Exclusion Criteria:

* Known hypersensitivity to rabeprazole, clarithromycin, or amoxycillin
* evidence from endoscopic examination of gastrointestinal hemorrhage or stomach cancer, or had previous stomach surgery
* use of aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, bismuth, or proton pump inhibitors during the last 4 weeks prior to study initiation
* history of successful treatment to eradicate H.pylori infection
* females who are pregnant or nursing
GeneSearch Breast Lymph Node (BLN) Assay Timing Study

This study is designed to collect data about the amount of time required to use the assay in clinical-use conditions.

Assay turn-around-time will be collected at sites that are using the GeneSearch BLN Assay for intraoperative testing of sentinel lymph nodes. The sites must be planning to use the assay result to guide the decision to complete an axillary lymph node dissection.

Eligibility Criteria:
Inclusion Criteria:

* Pre-operatively established diagnosis of invasive carcinoma of the breast
* Scheduled for axillary sentinel lymph node dissection as per standard of care at the clinical site for newly diagnosed breast cancer patients
* Patients for whom the GeneSearch™ BLN Assay will be used intra-operatively to make a decision for an axillary lymph node dissection
* 18 years of age or older
* Female or male

Exclusion Criteria:

* Previous diagnosis of lymphoma
* Subjects participating in other research studies that would interfere with their full participation in this study
* Patients and/or conditions with 'interfering substances' as listed in the IFU
* Patients who have had any pre-operative treatment for breast cancer including neoadjuvant and/or hormonal intervention such as aromatase inhibitors or tamoxifen
Bariatric Surgery and Pharmacokinetics of Metoprolol

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on metoprolol are investigated.


Eligibility Criteria:
Inclusion Criteria:

* Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
* Being a Norwegian citizen

Exclusion Criteria:

* Having previously undergone resections in the GI-tract
Extracorporeal Ultrafiltration (UF) vs. Usual and Customary Care for Patients With Severe Heart Failure (HF)

The purpose of this study is to assess the ability of Ultrafiltration to influence the rate of hemodynamic improvement, as measured by the decline in the pulmonary artery occlusion pressure, in patients with NYHA class III/IV Heart Failure.

This study will be preformed in a specialized heart failure unit at the Cleveland Clinic Foundation (CCF) and will include both the UF-treated group and a control group receiving usual and customary care. Patients will be stratified according to renal function at the time of admission. Therapies will be guided by specific hemodynamic criteria routinely used at the study institution.

Eligibility Criteria:
Inclusion Criteria:

* Admitted to Heart Failure Unit (H-22) with NYHA class III/IV HF and pulmonary artery catheter in situ
* Left ventricular ejection fraction \<40%
* Mean Pulmonary Artery Occlusion Pressure ≥20 mm Hg
* Able to give informed consent

Exclusion Criteria:

* Currently on renal replacement therapy or determined to need renal replacement therapy at the time of enrollment
* Estimated glomerular filtration rate (GFR) \<15 mL/min
* Systolic blood pressure (SBP) \<80 mm Hg
* Acute coronary syndrome
* Hematocrit \>50%
* Malignancy other than prostrate or skin
* Chronic edematous states other than HF, including nephritic syndrome and cirrhosis
* Chronic inflammatory or infectious condition
* Pregnancy
* Previous enrollment in this study
* Expectation of need for heart transplantation or cardiac assist device within one week
* Pulmonary failure requiring intubation and mechanical ventilation
* Known or suspected hypersensitivity to dialysis membranes
* Severe aortic stenosis or regurgitation
* Severe mitral stenosis
Effects of Fluid Therapy on Microcirculatory Reactivity

Through preoperative fluid therapy, to investigate whether it can alleviate the microcirculation dysfunction after induction of anesthesia, and reduce the incidence of perioperative fluid therapy-related complications, thereby accelerating rehabilitation.

Patients undergoing minimally invasive coronary artery bypass graft surgery were randomly divided into crystal group, colloid group and control group. The preoperative fluid reactivity was evaluated according to the passive leg lifting test (PLR). When stroke volume increased (△SV)\>16%, the patients in the crystal (carbonate Ringer solution) and the colloid group (hydroxyethyl starch solution) were treated with volume therapy, while the control group was not treated with PLR test and volume therapy. Vascular occlusion test was used to observe the effect of anesthesia induction on tissue oxygen saturation recovery slope (RecStO2) after volume therapy, Goal-directed fluid therapy was used during operation, and the postoperative microcirculation function and the incidence of related complications were observed.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years old
* Plan to undergo elective minimally invasive coronary artery bypass grafting (left anterior descending branch);
* Sign informed consent

Exclusion Criteria:

* Left ventricular ejection fraction \<40%
* Diabetes
* Renal insufficiency (serum creatinine\>177umol/L)
* Liver insufficiency (AST, ALT\>3 times)
* Peripheral vascular disease
* Carotid artery stenosis (\>60%) VOT test contraindications (arm deformity, burns, arteriovenous shunt)
* Use glucocorticoids, vasoactive drugs, inotropic drugs or intra-aortic balloon counterpulsation (IABP)
* Allergic to colloidal fluids
Non-pharmacological Analgesic Effects on Term Newborns

The purpose of this study is to compare the analgesic effects of four non-pharmacological interventions: skin-to-skin contact, breastfeeding, oral sucrose and nonnutritive sucking in newborns receiving a heel lance procedure.

This is an randomized control clinical study. study population is healthy term newborns.Patients were identified by chart review and consent was received by nurse researcher. Newborns were randomized into either the control group who received no pain intervention or the intervention group who received one of four non-pharmacological pain interventions: skin to skin contact, breastfeeding, oral sucrose, and nonnutritive sucking.

A heel lance for newborn screen blood sampling was selected as a study procedure and performed by a hospital technician following standard protocol. Pain scoring was assessed by two research nurses after the hell lance and through the procedure. Neonatal Pain, Agitation and Sedation Scale (NPASS) was selected as a pain assessment tool for this study.

The average pain score from two research nurses were used for statistical analysis.

Eligibility Criteria:
Inclusion Criteria:

* Gestational Age 38-40
* 2.5-4.0kg
* 24-48hours of age
* Receiving heel lance procedure
* Apgar\>7 at birth
* NPASS\<3 at time of heel lance

Exclusion Criteria:

* Prior heel lance procedure
* birth trauma
* forceps or vacuum delivery
* maternal drug abuse during delivery
Characteristic of Drug Users Chronic Wound

The aim of this study is to describe demographic, clinical, etiological characteristic and evolution of drug addict's chronic wounds .


Eligibility Criteria:
Inclusion Criteria:

* all drug addict with chronic wound ( evolving at least since 1 month)

Exclusion Criteria:

* use following medication inductor of cutaneous ulcer: hydroxycarbamide, gefitinib, cetuximab, sunitinib, sorafenib, pazopanib, gemcitabine, sirolimus, methotrexate, nicorandil .
Investigation on the Efficacy of WO 2085 Moisturising Cream for Breast Cancer Patients Suffering From Vulvovaginal Dryness

The aim of the study is to gain further experience with regard to the performance of the medical device WO2085 Moisturising Cream for breast cancer patients undergoing chemotherapy or treatment with anti-oestrogens / aromatase inhibitors

The goal of this application study was to answer the question as to whether the application of WO2085 Moisturising Cream for breast cancer patients undergoing chemotherapy or treatment with anti-oestrogens / aromatase inhibitors can result in an improvement in the subjective symptoms and objective diagnoses of vulvovaginal dryness while also ensuring good tolerability.

Eligibility Criteria:
Inclusion Criteria:

* Women with breast cancer undergoing chemotherapy OR therapy with aromatase inhibitors or anti-oestrogens (either at present or up to 3 months after ending treatment) AND with symptoms of vulvovaginal dryness since the start of tumour treatment
* Written declaration of consent for the voluntary participation in the study is present

Exclusion Criteria:

* Women who suffered symptoms of vulvovaginal dryness prior to the start of tumour treatment
* Patients undergoing radiation therapy
* Patients with other tumours
* A current vaginal infection
* Medical conditions related to the vulva or vagina
* Current additional therapy of vulvovaginal dryness or vulvovaginal atrophy
* Women who are not able to participate properly in this study
* Current alcohol and/or drug abuse
* Pregnant or lactating women
Effect of VRGs on Changing the Center of Gravity Location in AIS

The purpose of this clinical trial is to examine the effect of virtual reality games (VRG) on changing the location of the center of gravity in children with adolescent idiopathic scoliosis (AIS).

Twenty-four patients with AIS will be randomly allocated to two groups. The intervention group will apply to the virtual reality games and basic correction exercises group for six weeks (18 sessions). The control group will be given the basic correction exercises. Patients' center of gravity (Physiosoft Balance System), posture parameters (PostureScreen Mobile, Posterior Trunk Asymmetry Index (POTSI) and Anterior Trunk Asymmetry Index (ATSI)), cosmetic perception (Walter Reed Visual Evaluation Scale (WRVAS)) will assess at the first session and the end of 6 weeks.

The most common type of scoliosis is adolescent idiopathic Scoliosis (AIS). It affects 1-4% of adolescents. AIS is associated with cosmetic problems, pain, functional limitations, respiratory dysfunction and a decrease in quality of life. Although scoliosis is characterized by lateral spinal deviation, it causes a three-dimensional deformity with geometric and morphological changes in the trunk and rib cage. The main changes are postural changes in the orientation of the head, shoulders, scapula and pelvis in all three planes, but more specifically rotations of body segments in the horizontal plane. Spinal deformity not only changes the shape of the trunk, but also the relationships between body segments. Therefore, it leads to an abnormal change in the center of gravity. While various treatment approaches are recommended in the management of AIS to overcome these and other complications, scoliosis-specific corrective exercises are almost always part of the treatment plan for individuals with AIS. However ,Virtual Reality Games (VRGs) have recently been used in health and rehabilitation research due to recent technological developments and changes. In the literature, VRGs have been shown to have a positive effect on changing the position of the center of gravity in different rehabilitation areas. However, there is no study examining the effect of the use of VRGs on the chaning of the center of gravity Location in the treatment of AIS.

Eligibility Criteria:
Inclusion Criteria:

* Being diagnosed with Adolescent Idiopathic Scoliosis
* Being the Cobb angle between 10 and 25 degrees on the anteroposterior radiograph
* Being between the ages of 11 and 18
* Volunteering to participate in the study

Exclusion Criteria:

* Having a history of spinal surgery and/or tumors
* Using braces and insoles
* Having a positive result of sharpened Romberg and Unterberger test
* Having orthopedic problems affecting the lower extremities that may affect balance
* Having problems with vision and/or hearing
* Having a communication disability
* Having difficulty with understanding given commands
* Having neurological or cognitive impairments
* Receiving conservative treatment for AIS
New Service Protocol for Attention Deficit/Hyperactivity Disorder With Comorbidity: A Randomized Waitlist-controlled

The proposed study is to be carried out in 2021 - 2024 with youths aged 6 - 15 in Hong Kong. This is a randomized waitlist-controlled trial that aims to examine the effectiveness of the ADHD+ new service protocol. This ADHD+ new service protocol intervention will be delivered for 6 months in the format of groups by frontline social workers trained by professional clinicians including clinical psychologists and psychiatrists. It is designed to reduce ADHD and related symptoms in individuals aged between 6 and 15 years.

Core treatment components include internet use/addiction intervention, cognitive training, emotion management, social skills training, occupational training, emotion support/befriending, parenting training, and career guidance. It is hypothesized that youths receiving the intervention will have reduced ADHD and related symptoms when compared with controls.

Findings will allow the investigators to better understand the effectiveness of the new ADHD+ service; and in the long run, the service model can be generalized to community based early interventions for other uncomplicated mental disorders.


Eligibility Criteria:
Inclusion Criteria:

* children, adolescent and young adults (Aged 6-15);
* have sufficient proficiency in Chinese to understand verbal instructions and give informed consent;
* clinically significant mild to moderate ADHD syndromes requiring intervention;
* without learning disabilities and intelligence quotient (IQ) score not lower than 70;
* are "more likely to commit time in the projects" for reasons such as intention to treat and
* receiving the New ADHD+ service.

Exclusion Criteria:

* known diagnosis of intellectual disability;
* not reaching syndrome diagnostic threshold for ADHD;
* already receiving medical interventions / treatments at Hospital Authority (HA) and/or private sector;
* known psychiatric diagnosis (stabilized diagnosis and treatment);
* current or active suicidal ideation or attempts;
* have received structured psychosocial intervention for more than 3 contact hours (for waitlist group); and
* refusal to give consent.
Detection of Acetylsalicylic Acid and Omega-3 Fatty Acids in Schirmers' Test Strips Using Mass Spectrometry

Evaluation of tear fluid production using Schirmers' tests is a well-known and frequently used examination method in ophthalmology. Schirmers' test objectively indicates the tear fluid production over five minutes by insertion of a filter paper strip in the lower conjunctival fornix. Commonly, this method is used to quantify tear fluid production, but not tear fluid composition. The development of novel, very precise analytical methods opens up new possibilities in the use and application of Schirmers' test strips. A recently introduced analytical method is mass spectrometry. This method allows the detection and quantification of proteins, lipids, and metabolites in very low amounts of samples. Whether systemically ingested agents such as omega-3 fatty acids or acetylsalicylic acid can be detected in tear fluid using this method remains unclear. The aim of this study is to investigate the detectability of 2 different agents (acetylsalicylic acid and omega-3 fatty acids) in Schirmers' test strips from healthy subjects after intake for 1 week by use of untargeted mass spectrometry. Participating healthy subjects will receive either acetylsalicylic acid or omega-3 fatty acids.


Eligibility Criteria:
Inclusion Criteria:

* Men and women age of at least 18 years to 60 years
* Written informed consent prior to study-related procedures
* Normal ophthalmic findings
* No use of eye drops including topical lubricants in the 4 weeks before screening

Exclusion Criteria:

* Participation in a clinical trial in the 3 weeks preceding the study
* Symptoms of a clinically relevant illness in the 3 weeks before the first study day
* Presence or history of a severe medical condition as judged by the clinical investigator
* Intake of any drugs or dietary supplements within three weeks before the first study day (except contraceptives)
* TFBUT \<10 sec.
* Glaucoma in the medical history
* Ocular infection or clinically significant inflammation
* Ocular surgery in the 3 months preceding the study
* Pregnancy, planned pregnancy or lactating
* Known hypersensitivity to any component of the study medication
Lavender Oil on Preoperative Anxiety and Sedation Requirement in General Anaesthesia

Assessment of how Lavender oil reduces preoperative anxiety and subsequently influences requirement of induction agents for general anesthesia.

This study aims to use aromatherapy (Lavender oil) to reduce Preoperative Anxiety among Female patients coming for elective surgeries under General Anesthesia.

As a consequence of that, the effect is also evaluated on how that influences the amount of intravenous sedation is required during induction for General Anesthesia.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-65
* Female

Exclusion Criteria:

* Patients on B-blockers and or antidepressants.
* BMI \> 35kg/m2
* History of atopy
* History of alcoholism, substance abuse, smoking
* Patients with cancer