cyrilzakka/clinical-trials huggingface dataset:
Prevalence of Abuse Among Patients With Rheumatic Diseases

Patients with rheumatic diseases (RD) have a relevant representation in the adult population in Mexico. RD are characterized by their chronic and progressive nature, which can impact functionality during the disease and can present various factors that can be associated with the presence of abuse, among others, economic dependence, decreased physical capacity, and need for care and support in different health processes.

Regarding abuse in patients with RD, there is little information in the literature; however, it is possible that the prevalence could be similar to that of the occurrence in older adults since both populations share important states of vulnerability.

The study aimed to identify the prevalence of abuse in patients with RD. The study will be conducted in two phases: the first one in which the GAS will be adapted for patients with RD, and this version will be validated in a population of our Institute, and the second one in which, applying the validated instrument, the magnitude of abuse is evaluated, and the factors associated with this phenomenon among patients with RD are explored.

Patients with rheumatic diseases (RD) have a relevant representation in the adult population in Mexico. RD are characterized by their chronic and progressive nature, which can impact functionality during the disease and can present various factors that can be associated with the presence of abuse, among others, economic dependence, decreased physical capacity, and need for care and support in different health processes.

In 1970, the phenomenon of abuse in geriatric patients was described for the first time as a phenomenon identified as a public health problem and an issue of human rights violation.

In 2012 Giraldo-Rodríguez developed and validated the Geriatric Abuse Scale (GAS), an instrument that, with adequate psychometric properties, reported a prevalence of abuse of 10.28% in Mexico.

Regarding abuse in patients with RD, there is little information in the literature; however, it is possible that the prevalence could be similar to that of the occurrence in older adults since both populations share important states of vulnerability.

The study aimed to identify the prevalence of abuse in patients with RD. The study will be conducted in two phases: the first one in which the GAS will be adapted for patients with RD, and this version will be validated in a population of our Institute, and the second one in which, applying the validated instrument, the magnitude of abuse is evaluated, and the factors associated with this phenomenon among patients with RD are explored.

Eligibility Criteria:
Inclusion Criteria:

* Patients with a rheumatic disease diagnosis according to their primary rheumatologist who agree to participate

Exclusion Criteria:

* Patients with a not confirmed rheumatic disease
Virtual Reality for Burn Wound Care Pain Control

The investigators propose to study the effects of virtual reality (VR) on patients' pain perception during burn wound care. Such variables include psychiatric diagnosis and standard pain coping (i.e. pain catastophizer vs. non-pain catastrophizer).Aims: The investigators intend to evaluate the use of virtual reality in pain distraction for burn patients undergoing burn wound care. To that end our aims are: 1) To determine if pain perception will be less during the portion of the procedure in which the patient is immersed in the VR session in comparison to the portion of wound care which will occur without VR immersion. 2) To determine if anticipatory anxiety will be less for the portion of wound care that includes the virtual reality in comparison to the portion without virtual reality. 3) To determine if current psychiatric diagnosis, especially acute stress disorder and depression, is related to higher pain perception and greater decrease in pain with the virtual reality distraction. 4) To determine if being a "pain catastrophizer" is related to higher pain perception and greater benefits from the


Eligibility Criteria:
Inclusion Criteria:

* Age 12-100years
* Minimum burn wound size of 2% total body surface area (TBSA) excluding head and dominant hand
* Be able to sit upright independently in bed
* Minimum pain rating of 4/10 on a Visual Analog Scale (only using the most painful extremity).
* Able to consent to the study

Exclusion Criteria:

* Known history of motion sickness
* Seizures
* Migraines
* Current psychosis, dementia, or delirium
* Current blindness and/or deafness that significantly affects their ability to experience the VR
Alpha-synuclein in Cerebrospinal Fluid to Differentiate Alzheimer's Disease From Lewy Body Disease.

Patients with memory disorders are experiencing different trends which are difficult to predict. Moreover, the distinction between Lewy body disease and Alzheimer's disease is not easy as both diseases can present similar symptoms. Nowadays, routine examinations exist and can improve the diagnosis but there are not specific enough of one of those two pathologies.

Lewy body disease is characterized by the presence of particular structures in patient's brain, called "Lewy body", composed of a protein called "alpha-synuclein". The aim of this study is to measure the rate of alpha-synuclein in cerebrospinal fluid. This measurement could allow us to differentiate patient with Alzheimer's disease from those with Lewy body disease.


Eligibility Criteria:
Inclusion Criteria:

* At least 45 years of age
* Subject agrees to participate in the study
* Subject meets the criteria Dubois et al., 2007. for diagnosis of probable AD.
* Subject with a syndromic presentation of mild cognitive impairment or mild dementia
* Subject has a study partner who is able to provide accurate information about the patient
* Subject affiliated to a social security scheme

Exclusion Criteria:

* Patient who meets both AD and Lewy Body disease criteria
* Contraindications to lumbar puncture
* Contraindications to an MRI scan
* Subject who is not affiliated to a social security scheme
* Subject under guardianship or curatorship
* Subject under judicial protection
* Subject refuses to participate in the study
* Subject has evidence of clinically relevant neurological disorder (fronto-temporal dementia, brain tumor, stroke, ...) that led to persistent cognitive disorders
* Subject has evidence of clinically relevant psychiatric disorders (schizophrenia, major depression, ...)
* Pregnant or attempting to become pregnant women
* Subject's vision and audition is sufficient for neuropsychological tests's assessment, based on the investigator's judgment.
Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments

Inappropriate antibiotic prescribing for acute respiratory infections (ARIs) persists despite decades of intervention efforts. Negative outcomes of inappropriate antibiotics include increased costs of care, adverse drug reactions, and rising prevalence of antibiotic-resistant bacteria. To address this public health problem, we apply the principles of commitment and consistency in an effort to influence clinician decision-making through the implementation of a low-cost behavioral "nudge" in the form of a simple public commitment device. Clinicians were asked to post in their exam room a signed letter indicating their commitments to reducing inappropriate antibiotic use for ARIs. Our hypothesis is that clinicians displaying the poster-sized commitment letters will decrease their inappropriate antibiotic prescribing for ARIs as compared to clinicians in the control condition (with no posted letter).


Eligibility Criteria:
Inclusion Criteria:

* Medical professionals licensed to provide care and prescribe medications (including antibiotics)
* Treating adult patients (18 years of age and older) from 5 Los Angeles community clinics

Exclusion Criteria:

* none
VR Homework Exercises for Selective Mutism Treatment

Selective mustism (SM) is an anxiety disorder that manifests in childhood. Children with Children with SM do not speak in certain social situations where this is expected of them. For example, a child may talk at home, but is afraid to speak at school. The goal of this clinical trial is to determine the efficacy of behavioral therapy for children with selective mutism (SM) combined with virtual reality (VR) homework exercises. Virtual Reality Exposure is an effective treatment for adults with anxiety disorders.

The main questions to answer are:

* Is behavioral therapy combined with VR homework exercises effective in the treatment of SM?
* Which familial factors contribute to a positive treatment outcome and homework adherence?

A single-case experimental design (SCED) will be used to evaluate the efficacy of the treatment. The child's speaking behavior at baseline will be compared to the child's speaking behavior in the different phases of the intervention.

Participants will:

* Follow individual therapy sessions at school.
* Practice with the VR homework exercises at least once a week.
* Parents and teachers will evaluate the child's speaking behavior.

The treatment in this study consists of behavioral therapy for SM (with the protocol 'Talking at school, a matter of doing') with the addition of the VR homework exercises. The protocol consists of 10 steps that help the child to gain confidence while speaking at school. The individual therapy sessions are provided at school. For every step of the protocol there are VR homework exercises available. Families receive a VR headset for the duration of the study. Parents are instructed to work on the VR homework exercises at least once a week and encouraged to work on the VR homework exercises several times a week. On average, treatment is approximately 25 weeks.

Eligibility Criteria:
Inclusion Criteria:

* The child meets the DSM-5 criteria for SM (as a primary classification).
* The child is attending primary school.
* Referred to an academic center for Child and Adolescent Psychiatry (Levvel) for diagnosis and treatment of SM
* Psychiatric comorbidity is permitted, given that SM is the primary treatment target.
* Medication use is permitted, if stable for at least 4 weeks prior to the start of treatment.

Exclusion Criteria:

* No participating parents.
* Parents do not have sufficient mastery of the Dutch language.
* Parents or child have an estimated IQ below 75.
* The child needs inpatient treatment.
* Children with a (medical) condition that is a contraindication for using a VR headset (epilepsy, claustrophobia, facial condition, sensitive vestibular system, panic attacks)
* Parents receiving parental guidance which is not part of the standard treatment program.
* Children that have received protocolled behavior therapy for SM in the past 12 months.
Long-term Exercise Effect of EX1 Exercise Program

The purpose of this study was to investigate the effect of a long-term exercise program using a wearable exoskeleton robot (EX1) on muscular strength in healthy adults aged 19 to under 65 years, compared to an exercise program without EX1.


Eligibility Criteria:
Inclusion Criteria:

* Healthy adults aged 19 to less than 65 years without a history of central nervous system disease

Exclusion Criteria:

* Those who have difficulty walking independently due to problems such as visual field defects or fractures
* Those who have difficulty participating in exercise programs due to adult diseases such as uncontrolled hypertension and diabetes
* Those who are at risk of falling while walking due to severe dizziness
* Those who are less than 140 cm or more than 185 cm in height that is not suitable size for the wearing of the walking assistance robot
* Those who are overweight based on body mass index (BMI) 35 or higher
Awareness, Care & Treatment In Obesity Management - An International Observation

The purpose of this survey is to collect the data on perceptions, behaviours and awareness related to obesity and obesity management for People with Obesity (PwO) and Health Care Professionals (HCP) treating obesity. Data will be collected via online surveys among each of the respondent groups. The surveys are expected to take approximately 25 minutes to complete and will be unique for PwO and HCP. As a cross-sectional study, there will be no treatment of patients.


Eligibility Criteria:
Inclusion Criteria: - PEOPLE WITH OBESITY - Age at least 18 years, both males and females - On-line consent to participate in study - Lives in one of the participating countries: Italy, Spain, United Kingdom (UK), Brazil, Chile, Mexico, Australia, Israel, Saudi Arabia, United Arab Emirates (UAE), Japan, South Korea - Current Body Mass Index (BMI) (based on self-reported height and weight) greater than or equal to 30 kg/sqm in Italy, Spain, UK, Brazil, Chile, Mexico, Australia, Israel, Saudi Arabia, UAE; current BMI greater than or equal to 25 kg/sqm in Japan and South Korea - HEALTH CARE PROFESSIONALS - Physician - Specialty is NOT plastic surgeon, general surgeon, or bariatric surgeon - Practices in one of the participating countries: Italy, Spain, UK, Brazil, Chile, Mexico, Australia, Israel, Saudi Arabia, UAE, Japan, South Korea - In practice at least 2 years - Spends at least 70 percent of time in direct patient care - Has seen at least 100 patients in past month - Has seen at least 10 patients in past month needing weight management defined as: a patient with a BMI greater than or equal to 30 kg/sqm with or without comorbidities. (BMI greater than or equal to 25 kg/sqm in Japan and South Korea) Exclusion Criteria: - PEOPLE WITH OBESITY - Declines to provide income - Previous participation in this study. Participation is defined as having given online consent in this study - Declines to provide race / ethnicity (in applicable countries) - Currently pregnant - Participates in intense fitness or body building programs - Has had significant, unintentional weight loss (due to major injury, illness, etc.) in the past 6 months
Evaluation of Nutritional Habits of University Students

This cross- sectional, single-center study was conducted with the participation of 912 students studying at \[removed for blind peer review\] Faculty of Health Sciences, Faculty of Engineering and Natural Sciences, Faculty of Educational Sciences, Faculty of Social Sciences, Faculty of Law and Medicine. The sample size was calculated to be a minimum of 379 with 95% confidence over the total number of students, 5301. The study was carried out between October 2020 and December 2020. The compliance of the study with the ethical rules was evaluated by the Istanbul Medeniyet University Social and Human Sciences Research and Publication Ethics Committee at its meeting dated 27.10.2020 and approved with the decision numbered 2020/39.

At the beginning of the study, verbal and written consent was obtained from the individuals and a questionnaire containing 29 questions was distributed by the researchers. The questionnaire form consists of three parts. The first part includes 10 questions to determine the demographic characteristics of the participants, the second part includes 17 questions to determine their eating habits, and the third part includes 2 questions to evaluate the status of following the news about nutrition and heart health and whether they find the public service ads on this subject sufficient.


Eligibility Criteria:
Inclusion Criteria:

* Volunteering to participate in the research
* Istanbul Medeniyet University students between the ages of 18-25

Exclusion Criteria:

* Individuals who did not volunteer to participate in the study
* Adults over 25
* All university students studying outside of Istanbul Medeniyet University
* Elderly individuals
* Children under 18
Vitamin A in Brown Fat Activity

Vitamin A metabolites (retinoids) have shown to activate brown fat function in preclinical studies, however the role of retinoids in human brown fat physiology and energy metabolism remains elusive. This study aims to identify a possible association between retinoid metabolism, brown fat activity, and energy expenditure in lean and obese subjects by using FDG-PET-CT, PET-MR Scans and indirect calorimetry. Additionally we will analyze the genetic profile of white and brown neck fat biopsies at room temperature and cold conditions in a subset of the study participants. More detailed molecular studies (involving other potential browning markers) will also be performed in adipocytes derived from human SVC.

The optimal duration of cold exposure will be determined in a pilot study. Therefore subjects will be repeatedly exposed to cold and circulating retinoid levels and other plasma parameters will be measured at various time points.


Eligibility Criteria:
Inclusion Criteria:

* Age 20 - 45 years.
* Body mass index (BMI) 18.5 - 24.9 kg/m2 (lean) or 30.0 - 38.0 kg/m2 (obese)

Exclusion Criteria:

* Endocrine (except hyperlipidemia), cardiovascular (except hypertension), liver, kidney, inflammatory bowel, rheumatic, oncologic disease or any other chronic condition.
* Medication for any of the above mentioned conditions.
* Pregnancy
* Metallic implants that are not MRI compatible
Career Enhancement Training Study (USAF)

A study evaluating a training program to decrease risk for suicidal thoughts and behaviors among early career trainees in the United States Air Force.

Relationship disruptions and social isolation are major precipitants for military suicides and a range of problems that impair functioning and reduce mission readiness. However, nearly all current military suicide prevention programming focuses on a narrow range of approaches for individuals already at high-risk (e.g., training to detect warning signs and refer for treatment services). This project addresses the need for universal prevention approaches to proactively strengthen protective factors across military populations, including strengthening social connectedness and skills to grow and sustain relationships across service.

The aims of this project are to (a) develop an intervention for early-career, enlisted United States Air Force personnel using an active training approach to strengthening social bonds, and (b) test the intervention (i.e., Wingman-Connect) using a randomized controlled trial design.

Wingman-Connect focuses on Airman-in-Training to build protective factors in: Kinship (healthy bonds); Guidance (support from mentors and mental health); Purpose (goals, sense of being valued and valuable); and Balance (self-care and support). Half of the training is focused on the class as a group to build belonging and shared purpose.

Eligibility Criteria:
Inclusion Criteria:

* Airmen-in-Training (AiT) in Technical Training classes in the 365 or 363 Training Squadrons of the 82 Training Wing (82 TRW)
* Eligible classes must be between 37-91 class days in length

Exclusion Criteria:

* Airmen from other countries receiving training in US
* Airmen who are not in their first year of enlistment
Dose-Proportionality and Food Effect Study of TNX-102 SL

This will be a single center, single-dose, randomized, open-label, 3-period, crossover, dose-proportionality and food-effect study.


Eligibility Criteria:
Inclusion Criteria:

* Male or female, non-smoker, ≥18 and ≤65 years of age, with Body Mass Index (BMI) \>18.5 and \<30.0 kg/m2
* Females of childbearing potential must be willing to use a medically acceptable method of birth control throughout the study
* Capable of consent

Exclusion Criteria:

* Any clinically significant abnormality or abnormal laboratory test results found during medical screening
* Positive hepatitis B, hepatitis C, HIV, urine drug screen, urine cotinine test, or alcohol breath test at screening
* History of allergic reactions to cyclobenzaprine, any of the formulation components, or other related drugs
* Use of any drugs known to induce or inhibit hepatic drug metabolism within 30 days prior to the first study drug administration
* Positive pregnancy test at screening
* Clinically significant electrocardiogram (ECG) abnormalities or vital sign abnormalities at screening
* History of significant alcohol or drug abuse within one year prior to screening
* Participation in a clinical trial involving the administration of an investigational or marketed drug within 30 days prior to the first dosing or concomitant participation in an investigational study involving no drug administration
* Use of medication other than topical products without significant systemic absorption and hormonal contraceptives
* Donation of plasma within 7 days prior to dosing, or significant loss of blood within 54 days of dosing.
* Abnormal hemoglobin and hematocrit levels at screening
* Breast-feeding subject
* Presence of orthodontic braces or orthodontic retention wires, or any physical findings in the mouth or tongue that would be likely to interfere with successful completion of the dosing procedure
Exercise-Induced Epigenetic Modifications in Obese Aging Women

Our greatest public health challenge is obesity and the co-morbidities of metabolic syndrome (MetS). Age is an established risk factor for MetS and specific to women, data indicates that the prevalence of MetS increases substantially with the menopausal transition with postmenopausal women having a 60% increased risk of MetS. Menopause also contributes to reductions in strength, physical function and often psychological well-being (e.g. fatigue). Obese individuals also have: a) impaired immune function and chronic inflammatory responses associated with changes in the white blood cell population in blood and fat tissues; and, b) increased secretion of and signaling by proteins in their fat cells. Weight loss, which requires an energy deficit through increased physical activity and/or caloric restriction (EX+CR), reduces risk for MetS in older sedentary obese women by reducing insulin resistance and chronic systemic inflammation. Science and clinical practice will be advanced by examining the molecular mechanisms by which EX+CR affects risk for MetS in older women. The primary aim is to determine if CD4+ T cells will report the differential epigenetic reprogramming of relevant gene expression associated with metabolic indices resulting from EX+CR induced weight loss in older women known to be at risk for MetS. This pilot data will be used to generate an NIH proposal of the same topic. A secondary aim is to assess the impact of weight loss on physical function and psychological well-being which will provide pilot data for an additional grant proposal regarding weight management in postmenopausal women.


Eligibility Criteria:
Inclusion Criteria:

1. Volunteer for the study
2. Age between 50 and 64 years
3. Self-identified as White or Caucasian
4. Postmenopausal
5. Sedentary (less than 1 hour each week of planned physical activity and sedentary job)
6. BMI range \>/= 25 kg/m2
7. Waist circumference \>88cm
8. Weight stable (within 2 kg) for 6 months
9. All allowable medications stable for 3 months
10. Live independently
11. Willing and able to obtain transportation to and from lab sessions
12. Obtains physician clearance to participate in the study

Exclusion Criteria:

1. Tobacco use
2. Normal weight (BMI \< 25 kg/m2)
3. Males
4. Dietary restrictions that do not allow for the consumption of beef, as required by our dietary protocol
5. Weight loss surgery and/or weight loss medications usage
6. Mini-mental state exam score \< 25
7. Recent or history of unstable CVD
8. Cancer treatment within the last 5 years or active cancer
9. History of lung disease or COPD or severe asthma
10. History or severe arthritis or other medical condition that precludes ability to exercise to level needed by study.
11. Current diagnosis or history of balance disorders
12. History of mental disorders, dementia, clinical depression or other disorders that preclude adherence to protocols.
13. Current weight of 350 pounds or greater, due to weight restrictions on equipment.