cyrilzakka/clinical-trials huggingface dataset:
Economic and Psychological Burden of Infertility Among Women Attending Women Health Hospital, Assiut University

Rational of the study:

Infertility is a significant reproductive health issue for couples worldwide. The effects of infertility are wide-ranging-from mental health issues such as anxiety and depression to social and economic issues such as ostracization and economic problems. Although infertility affects both men and women, the woman in a couple is most often blamed for the inability to bear children.

Infertility is a disease of the male or female reproductive system, defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse (WHO).

Large numbers of people are affected by infertility in their lifetime, according to a new report published by World Health Organization. Around 17.5% of the adult population - roughly 1 in 6 worldwide - experience infertility. The inability to conceive children is experienced as a stressful situation by individuals and couples all around the world. The consequences of infertility are manifold and may include societal repercussions and personal emotional suffering. The infertile couple experienced greater dissatisfaction with themselves and their marriages. Females experienced greater discontent over time and had greater emotional problems than males because infertility had traditionally been viewed as a women problem and women have been expected to suffer greater emotional problems due to infertility. Treatment for infertility provides an opportunity for women and men to become parents. The evolution of assisted reproductive technology (ART) for the treatment of infertile couples is considered an extraordinary restorative accomplishment throughout the world. However accessibility of treatments such as IVF is limited to only those who can afford to pay out of pocket (OOP). Even among those who have the ability to pay, their willingness and financial ability to undergo multiple cycles of ART often depends on OOP payments incurred. However, due to the desire for a child, couples are often ready to make significant financial sacrifices often beyond their means. Couples are frequently willing to suffer catastrophic financial hardship instead of forgoing infertility care, resulting in negative economic consequences. Evidence suggests that in the absence of mechanisms for risk protection, OOP payments can push households into poverty.

Eligibility Criteria:
Inclusion Criteria:

* • reproductive age group 15 - 49

  * Duration of marriage not less than 1 year.
  * Has regular sexual intercourse without the functional use of contraceptive methods.
  * Free from any other debilitating chronic illness.

Exclusion Criteria:

* Women who have any previous psychological disease or treatment
Comparison of Smoflipid to Soy-based Lipid Reduction for Cholestasis Prevention in Surgical Neonates

Intestinal failure associated liver disease is a cholestatic liver disease associated with prolonged need for parenteral nutrition that can lead to such significant complications as liver failure. In the neonatal population, infants with history of intestinal resection and short bowel syndrome are at increased risk for this disease. The investigators plan to compare two possible lipid dosing preventative strategies including a composite, fish oil lipid and soy-based lipid reduction.

Intestinal failure associated liver disease (IFALD) is a cholestatic liver disease associated with prolonged need for parenteral nutrition. This disease can lead to such serious complications as liver failure and need for transplantation. In the neonatal population, short bowel syndrome, due to intestinal resection, is the most common cause of intestinal failure. While the exact cause is yet to be determined, it is felt the lipid component of parenteral nutrition is a large contributor to the development of this disease. Currently, there is no standard preventative strategy to attempt to decrease the risk of IFALD in the high risk, post-surgical neonatal population. The investigators aim to complete a randomized trial comparing two possible preventative strategies. One group will receive a composite lipid containing fish oil (Smoflipid) and the other group will receive soy-based lipid at reduced dosing.

Eligibility Criteria:
Inclusion Criteria: Neonates with anticipated need for parenteral nutrition (based on primary physicians opinion) for greater than or equal to four weeks and one of the following diagnoses:

* Anatomic: Neonate with intestinal atresia, omphalocele, gastroschisis, or volvulus with or without intestinal resection.
* Ischemic/perforation: Neonates with spontaneous intestinal perforation or necrotizing enterocolitis requiring surgical intervention.

Exclusion Criteria:

* Current weight less than 750 grams
* AST or ALT greater than 5 times the upper limit of normal within 2 weeks of enrollment
* Direct bilirubin greater than 2 mg/dL on any consecutive measurements 5 - 7 days apart within 2 weeks of enrollment
* Severe coagulopathy with INR greater than 95th percentile for age (\>1.7 at less than 5 days of age, \> 1.5 older than five days of age)
* Culture confirmed sepsis with positive blood, urine, or CSF culture within 2 weeks of enrollment
* Renal failure requiring dialysis
* Cyanotic heart disease requiring prostaglandin therapy
* Hypertriglyceridemia (greater than 250mg/dL) at time of enrollment
Swiss Prospective Autologous Bone Flap Resorption Study

The complications after reimplantation of cryoconserved autologous bone flaps are reported inhomogeniously in the literature. Especially the incidence of bone flap resorption varies from 0% to about 30%. More recent retrospective studies seem to find higher resorption rates and thus suggest to implant artificial bone replacements from the start. The Swiss Prospective Autologous bone Resorption Study is the first propspective observational study designed to determine the true incidence of autologous bone resorption.

Patients undergoing decompressive craniectomy and delayed reimplantation of the cryoconserved autologous bone flap are included in a clinical and image-based follow-up to identify cases and severity of bone flap resorption.

The explanted autologous bone flaps are cryoconserved and reimplanted at a time-point defined by the surgeon according to standards of the participating hospital. The fixation of the bone flap is also performed according to the surgeon's decision.

A cranial CT is performed within one week after reimplantation to define a baseline.

A second, only clinical, follow-up will take place within 2 months after reimplantation.

Two more follow-ups including photodocumentation of the cranial and facial symmetry (portrait and profile) and cranial CT will take place 12 and 24 months after reimplantation.

The indication for surgical revision in case of bone flap resorption is independent from the study and falls under the responsibility of the treating surgeon.

Eligibility Criteria:
Inclusion Criteria:

* all patients after hemicraniectomy or bifrontal craniectomy
* age 18-99 y/o
* ability to understand and sign informed consent (alternatively, legal representative may sign)

Exclusion Criteria:

* bone flap not fit for reimplantation
* no cryoconservation performed but other technique
* pregnancy
* patient's death
Clinical Study, Opened, of Cutaneous Acceptability of a Topic Product in Normal Conditions of Use

The measured product in this research is a product for topical use, Laboratoires Mercurochrome Reparador e Protetor. The expected benefit to the use of the product is the improvement in skin hydration as measured by self perception of participant research and clinical evaluation and improvement in local microcirculation, assessed by instrumental measurements in feet of the study participants.

The objectives of this study is to verify the skin acceptability through the non-occurrence of adverse events and cutaneous sensations of discomfort, evaluate the moisturizing efficacy of the product through self perception of research participants and dermatological clinical evaluation to assess the improvement in local microcirculation by performing of instrumental measurements in the feet of diabetic participants, product Laboratoires Mercurochrome Repairer and Protector referred by LM FARMA INDUSTRIAL LTDA.

For this research, will be recruited up to 35 research participants who meet the inclusion / exclusion described in items 9.4 and 9.5 of the research protocol, to achieve a number of completion of 30 participants. Be recruited participants from both sexes, aged 18 and 65, which have dry skin on the feet and they are people with diabetes whose condition is stabilized.

Eligibility Criteria:
Inclusion Criteria:

* Participants healthy research;
* Intact skin on feet - grade 0 in the Wagner scale;
* Agreement to adhere to the procedures and requirements of the study and attend to the Office (s) day (s) and time (s) set (s) for evaluations;
* Ability to consent to participate in writing;
* Age 18 to 65 years;
* Research Participants of both sexes - including at least three men;
* Introducing dry skin on feet - dermatological proof.
* Participants with diabetes whose condition is stabilized

Exclusion Criteria:

* Pregnancy and lactation; skin pathology in the product application area;
* immune impairment;
* Current use of these medications for topical or systemic use: corticoid, immunosuppressants, antihistamines, anticoagulants or birth;
* Skin diseases: psoriasis, vitiligo, atopic dermatitis;
* History of reaction to the category of the product tested;
* Other diseases or medications that may interfere directly in the study or to endanger the health of the research participant.
Sinus Floor Elevation Using Alpha-Bio's GRAFT Natural Bovine Bone vs. Commercially Available Bone Graft

This clinical study is designed to compare the regenerative outcome of using separately two different Xenografts during sinus floor augmentation.

Aim of this prospective randomized-controlled clinical trial is to compare the regenerative results of Alpha-Bio's GRAFT Natural Bovine Bone versus commercially available bone graft after two-step sinus floor elevations by clinical and histological analysis.

Clinical Parameters are wound healing parameters, radiological volume stability and implant survival rates. Histological parameters are based on a histomorphometrical analysis of trephine cores harvested in progress of implant bed preparation.


Eligibility Criteria:
Inclusion Criteria:

1. Patients who will present with a moderately or severely atrophic posterior maxilla with 1-6 mm residual alveolar bone will be selected for the study.
2. Men and women over the age of 18 years.
3. Patient has signed the Informed Consent.

Exclusion Criteria:

1. Chronic steroid therapy,
2. Uncontrolled diabetes,
3. Cardiovascular disease,
4. Past irradiation of head and neck
5. Maxillary sinus cysts,
6. Active chronic sinusitis,
7. Smoking more than ten cigarettes per day during the 3 months preceding this study .
8. Malignant disease in the 5 years preceding this study
9. Uncontrolled bleeding disorders such as: hemophilia, thrombocytopenia, granulocytopenia
10. Disease that compromise the immune system
11. Psychiatric disorder
12. Hypersensitivity to titanium, collagen or bovine bone.
13. Women who are pregnant or nursing.
14. Patients with non-treated periodontal disease.
15. Medical and/or general contraindications for intraoral surgical procedures
Dental Implants With a SLActive® vs. SLA® Surface

This post-market study is to show that dental implants with a SLActive® surface (SLActive® implants) show non-inferior clinical performance compared to dental implants with a SLA® surface (SLA® implants). The primary hypothesis is that 12 months after implant loading, the bone loss around the SLActive® implants will not be appreciably greater than around the SLA® implants.

The occurrence of adverse events and device deficiencies will also be recorded to confirm once more the safety of the Straumann® Bone Level Tapered (BLT), Roxolid® implant.

Osseointegration and anti-inflammatory potential of SLActive® implants will be evaluated in the study as secondary endpoints.

This is a prospective, single-blinded, randomized, paired sample, multi-center clinical study. Eight visits per patient are scheduled in this study. The final analysis will be conducted after all patients completed the 12-month visit.

The study devices are CE- (Conformité Européenne, meaning European Conformity) marked products and used within their intended use.

Two centers in Spain will participate.

Eligibility Criteria:
Inclusion Criteria:

* males and females, at least 18 years old
* partially edentulous patients in need of two or more dental implants (canine to molars) placed in two different quadrants in healed sites (3 months post extraction)
* subject must have voluntarily signed the informed consent, is willing and able to attend scheduled follow-up visits, and agrees that the encoded data will be collected and analyzed

Exclusion Criteria:

* any contraindications for oral surgical procedures
* dental implant placement contraindicated according to Instructions for Use (IFU)
* subjects with inadequate oral hygiene (FMPS ≥ 20%)
* subjects who are currently heavy smokers (defined \>10 cigarettes per day or \>1 cigar per day) or who use chewing tobacco
* subjects with drug or alcohol abuse
* patients requiring soft tissue and bone grafting procedures
* inadequate bone volume
* severe bruxism or clenching habits
* women who are pregnant or planning to become pregnant at any point during the study duration.
* patients who have systemic factors that could interfere with the healing process of either bone or soft tissue or the osseointegration process (e.g. bone metabolism disturbances, uncontrolled diabetes mellitus, anticoagulation drugs/ hemorrhagic diatheses)
* patients with local factors that could interfere with the healing process, such as untreated periodontal diseases, acute infection of implant site, temporomandibular joint disorders, treatable pathologic diseases of the jaw and changes in the oral mucosa)
* conditions or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, or unreliability.
Failure of Vaginal Delivery After Induction

The study will compare the number of women who deliver vaginally after artificial initiation of labor pains(i.e. induction of labor) by two methods. Half of the women would receive tablet misoprostol vaginally and the other half would receive tablet misoprostol and foley's balloon catheter both.

Artificial initiation of labor pains has become a common occurrence. A variety of methods are employed to initiate labor pains. Labor pains are more successful in culminating into vaginal delivery if the neck of womb that is the cervix is soft (ripe). This is usually achieved by ripening agents. They include drugs and devices that help soften the cervix. Misoprostol and foley's balloon catheter both are used to soften the cervix so that vaginal delivery is possible. Both work on different aspects of the softening of cervix.

Misoprostol acts on shortening the cervix and making it more pliable Foley's balloon helps to open up the cervix that is it aids in dilating the cervical canal.

Eligibility Criteria:
Inclusion Criteria:

* Gestational age \> 37 weeks assessed by Last Menstrual Period and dating scan.
* Women with singleton pregnancy assessed by ultrasound.
* Fetus in vertex presentation assessed by ultrasound.
* Age 20-40 years.
* Bishop score \<4.

Exclusion Criteria:

* Non-consenting.
* Gestational age \< 37 weeks.
* Patients with history of placenta previa.
* Patients with history of placental abruption.
* Ruptured membranes.
* Patients with history of vaginal infection.
* Patients with history of congenital anomalies in previous deliveries.
* Patients with history of stroke, renal impairment and chronic obstructive pulmonary disease, chronic liver disease and congestive cardiac failure
Nutrition and Cognitive Function in Preadolescents

This study is designed to evaluate cognitive function in preadolescents who have different body mass indexes.

The investigators plan to document differences between normal weight and obese preadolescents on psychological and neurocognitive measures of executive function controlling for factors known to influence brain function and behavior not considered in previous studies.

Eligibility Criteria:
Inclusion Criteria:

* Normal weight (BMI: \<85th percentile) or obese (BMI: \>95th percentile)
* Right hand dominance
* Report eating breakfast at least 4 days/week
* Able to hear at least 20 dB stimulus
* Visual acuity must be at least 20/40
* Arithmetic Computation Task
* Biological mother available to attend the enrollment study visit

Exclusion Criteria:

* Full Scale IQ \<80
* Children taking medications or having chronic illnesses/disorders that may independently affect study outcome measures (as determined by the PI)
PULSE OXIMETRY Performance Test for a Software Medical Device 'Vitacam'

This clinical investigation aims to collect data for algorithm development and testing of Vitacam as well as to later validate the system using a simultaneously collected, but segregated, hold-out validation dataset. Vitacam is a software medical device for measuring vital signs, manufactured by NE Device SW Oy. It analyses digital video recorded using a smart device with a camera to locate a subject's face and chest region. From both these regions of interest, the video is further analysed to obtain the heart rate, heartbeat intervals, respiratory rate and oxygen saturation. These measurements are used as inputs to clinical decision making. Vitacam uses remote photoplethysmography to obtain the heart rate and heartbeat intervals, and will build on this to obtain oxygen saturation using information from red-green-blue channels.

The main focus of this study is to validate the oxygen saturation, heart rate and heartbeat intervals measured by Vitacam against gold standard references, applying the ISO 80601:2019 standard.


Eligibility Criteria:
Inclusion Criteria:

* Age: 18-40 years
* ASA category 1
* Positive Allen's test
* Passing the physical examination
* Ability to give informed consent
* Volunteering for the study
* Fluent Finnish or English

Exclusion Criteria:

* Age under 18 years or over 40 years
* Smoker
* Pregnancy
* Does not pass the physical examination
* Negative Allen's test
* Relevant medical illnesses
* Cardiovascular disease
* Pulmonary disease
* Inability to give informed consent
* Denial
The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.


Eligibility Criteria:
Inclusion Criteria:

* critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion Criteria:

* patients with renal dysfunction
* those older than 80 years
* pregnant women
The Effects of Vibration and Kinesiology Tape Applications in Children With Hemiplegic Cerebral Palsy

The aim of this study was to evaluate the effects of vibration and kinesiology tape applications applied to the affected side forearm extensor muscles on dexterity in children with hemiplegic cerebral palsy.

Upper extremity in children with hemiplegic cerebral palsy significantly more affected than the lower extremities. Child mostly does not use the affected side and activity and weight uses the solid side in the overlay. in the upper extremity One of the muscles most affected by spasticity is the wrist and wrist. finger flexors. Secondary in antagonist of these muscles weakness develops and posture disorders occur. In this study The kinesiology tape, which has been increasingly used in recent years, affected by the application and local vibration application. hand with application to the lateral forearm extensor muscle group comparing their effects on their skills with the control group. aimed to evaluate. As a result of the study, this diagnosis hand skills of which application in children who are studying has a greater effect on and in which rehabilitation that the application should be preferred more It will be a guide for physiotherapists.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with hemiplegic cerebral palsy,
* No severe spasticity that prevents grasping and releasing an object (Modified which is at the level of 0, 1, 1+, 2 according to the Ashworth Scale),
* According to the Hand Skills Classification System (EBSS) at 1, 2 and 3 levels with function,
* Consisting of children between the ages of 4-18,
* Being treated in a special education and rehabilitation center,
* The family accepts the participation of their child in the study.
* They are children who have the mental level to take basic commands.

Exclusion Criteria:

* Having severe mental retardation that prevents communication and taking basic commands,
* The family does not accept the child to work,
* Severe spasticity that prevents grasping an object (Modified Ashworth 3 and 4 levels according to the scale),
* Hand function at 4 and 5 levels according to the Hand Skills Classification System (EBSS) the one which,
* Compliance and behavior during the application of the tests used to obtain the data are children with the disorder.