cyrilzakka/clinical-trials huggingface dataset:
Statin With Palliative Therapy for HCC

Statin is a preventive medicine for hepatitis B and hepatitis C which decreases the risk turning into liver cancer,however, the investigators also discovered that patients taking Statin live longer than patients who didn't take Statin in the incidence of liver cancer death cases.

Most liver cancer patients did not accept the cure as the main objective of the treatment after diagnosis because they choose alternative therapies palliative based, such as hepatic arterial chemoembolization, chemotherapy and radiation therapy.

Statin is a preventive medicine for hepatitis B and hepatitis C which decreases the risk turning into liver cancer, yet the clinical effect for Statin is still unknown.

In a previous study of 20,220 liver cancer patients in health care database, the investigators discovered that patients taking Statin live longer than patients who didn't take Statin in the incidence of liver cancer death cases.

This study is a continuation of previous health insurance database studies for clinical trials to verify whether Statin could prolong disease-free survival role for palliative treatment of liver cancer.

Eligibility Criteria:
Inclusion Criteria:

1. \>20 years old.
2. BCLC stage B , stage C and stage D

Exclusion Criteria:

1. Cancer diagnosis before HCC was conﬁrmed and incurable.
2. \<20 years old, \> 90years old.
3. Patients who are judged to be ineligible for study entry by the investigator or subinvestigator
A Qualitative Study on Patients' (un)Ability and (un)Willingness to Use Telemonitoring in Inflammatory Bowel Diseases

Introduction: Telemedicine has shown to play a promising role in improving IBD treatment. However, it remains uncertain which patients benefit from telemedicine. A feasibility and development project using IBD Care Everywhere (IBD-CE), a telemonitoring application, found that some patients were unable or unwilling to use the application. However, why patients were not able or willing to use the application remains unknown. The WHO global strategy aims to implement telemedicine while ensuring digital health equity. Concerns exist that telemedicine may exacerbate healthcare disparities.

Research question: The aim of this qualitative study is to get a better understanding of factors influencing patients' (un)ability and (un)willingness to use IBD-CE. These insights could help to offer the best individualised IBD care to patients. This led to the following research questions:

1. What influences patients' (un)ability or (un)willingness to use IBD Care Everywhere? 1.1 What are the distinguishing characteristics of patients (un)willing and (un)able to use IBD Care Everywhere? 1.2 How can care givers support patients in making an informed choice between telemonitoring and standard care?

Study design: This is a qualitative study using semi-structured interviews. Information about patient characteristics and potential factors that influence patients' ability or willingness to use IBD-CE will be collected. To guide the topics in the interview, three theories/models will be used:

1. The Unified Theory of Acceptance and Use of Technology (UTAUT) model
2. The COM-B model for behavioural change
3. The model of positive health Data will be analysed using thematic analysis.

Study population: Consecutive adult IBD patients (\> 18 years) in stable remission, visiting the outpatient clinic at the Jeroen Bosch Hospital and Franciscus Gasthuis \& Vlietland will be asked if the patients are willing to participate. Next, a total of 24 patients will be included through purposeful sampling. Both patients unwilling to use IBD-CE and patients interested in IBD-CE will be included. Should data saturation not have occurred, more patients will be included.

Expected results and relevance: The objective is to get better insights in the motivations of patients to choose for telemonitoring or standard care. This study aims to comprehend the requirements of patients to provide them with care that aligns with patients' needs.


Eligibility Criteria:
Inclusion Criteria:

* Aged \>18 years
* A confirmed IBD-diagnosis according to current guidelines
* Maintenance therapy with no medication changes in the last three months
* Remission:
* Crohn's disease: Faecal calprotectin (FCP) \< 100 µ g/g and Harvey Bradshaw Index (HBI) \< 5
* Ulcerative Colitis: Faecal calprotectin (FCP) \< 250 µ g/g and Simple Clinical Colitis Activity Index scores (SCCAI) \< 3

Exclusion Criteria:

* Presence of a stoma
* Presence of an ileo-anal pouch or ileorectal anastomosis
Ultrasound Guided Embryo Transfer: Abdominal Versus Transvaginal, a RCT

Ultrasound (US) guided embryo transfer (ET) appears to improve pregnancy outcomes in IVF-ET. Most reports are done using a transabdominal (TAS) approach, in contrast to a transvaginal ultrasound (TVS) which does not require a full bladder. We sought to determine if either approach was better with respect to clinical outcomes.


Eligibility Criteria:
Inclusion Criteria:

- All patients undergoing assisted reproductive cycles including autologous IVF, oocyte donation, and frozen embryo transfer (FET) cycles

Exclusion Criteria:

- Cases of severe ovarian hyper-stimulation requiring embryo cryopreservation and gestational surrogate cycles
A Diagnostic Test for Familial Mediterranean Fever

Familial Mediterranean Fever (FMF) is the most common auto-inflammatory disease (prevalence: 1-5 / 10,000 inhabitants). It is due to mutations of the MEFV gene, encoding variants of the Pyrin inflammasome. Inflammasomes are protein complexes of innate immunity producing pro-inflammatory cytokines (interleukin-1β).

In vitro, preliminary results demonstrated that activation of the Pyrin inflammasome (measured by interleukin-1β concentration) by kinase inhibitors is significantly increased in FMF patients compared to subjects with a similar clinical picture, and healthy controls. In addition, a measure of cell death yielded significant results in differentiating patients from controls.

The investigators hypothesize that this fast and simple functional test can serve as a diagnostic tool for FMF.


Eligibility Criteria:
Inclusion Criteria:

* Clinical picture compatible with an Familial Mediterranean Fever and an earlier genetic analysis finding a mutation of the MEFV gene;
* Newly diagnosed or undergoing follow-up (without criteria of delay or evolutionary stage);
* In the course of specific or non-specific treatment of the disease or without treatment;
* For whom a blood test is planned as part of the routine care;
* Of whom the informed non-opposition has been collected (parental authorization in the case of a minor patient);

Exclusion Criteria:

* patient under legal protection or under safeguard of justice or any other measures of protection (guardianship, curatorship);
* Person unable to express his consent;
* Person in emergency situation, vital or not;
* Infection known to HIV and / or HBV and / or HCV
Condyle Repositioning Using PSI and Prebent Plates Osteosynthesis Versus Conventional Mandibular BSSO Set-back Surgery

Patients with skeletal class III malocclusion were allocated to two groups. Both proximal and distal segments were repositioned using osteotomy/screw holes and plate locating surgical guides with pre-bent plates osteosynthesis in the intervention group, while manual free hand condylar segment seating was used for proximal segment positioning in the control group.

Twenty patients with skeletal class III malocclusion were randomly allocated to two groups. Both proximal and distal segments were repositioned using osteotomy/screw holes and plate locating surgical guides with pre-bent plates osteosynthesis in the intervention group, while manual free hand condylar segment seating was used for proximal segment positioning in the control group. Accuracy of condylar position was assessed using computed tomography.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients complaining of skeletal class III malocclusion that require BSSO for correction of their deformity

Exclusion Criteria:

* Patients require bi-maxillary orthognathic surgery
* patients with temporomandibular joint dysfunction
Scapular Dyskinesis: a Reliability and Validity Study of Comprehensive Classification Test

Study Design: Clinical measurement (cross-sectional)

Objectives: The purpose of this study was to investigate the reliability and validity of the novel scapular dyskinesis classification test.

Background: A visual-based clinical assessment with sufficient reliability and validity to identify scapular dyskinesis provides information for rehabilitation treatment.

Methods: A visual-based palpation method was evaluated by two independent physiotherapists in 60 subjects with unilateral shoulder pain to test reliability. This method classified the scapular movements during arm raising/lowing movements in scapular plane as single abnormal scapular patterns (inferior angle/ medial border/ superior border of scapula prominence and abnormal scapulohumeral rhythm) or mixed abnormal scapular patterns. Different patterns of scapular dyskinesis were also validated by corresponding alternation of the scapular kinematics and muscular activities assessed by electromagnetic motion-capturing system and surface electromyography (EMG).

No other detailed description

Eligibility Criteria:
Inclusion Criteria:

* (1) they were from 18 to 50 years old and (2) they had unilateral shoulder pain around shoulder complex during activities.

Exclusion Criteria:

* history of shoulder dislocation, fracture, or shoulder surgery within past 1 year, or a history of direct contact injury to the neck if upper extremities within the past 1 month, scoliosis or excessive kyphosis, neurological disorders, body mass index (BMI)≧25, or demonstrate pain (VAS\>3) during overall testing procedure.
Validation of an Obstacle Course Used in Patients With Muscle Tightness

This study is being conducted to compare healthy patients versus patients with muscle tightness in their leg(s) after an acquired brain injury using walking trials time, a balance test, and foot pressure data. This data is obtained using foot pressure sensors, timers, and distance walked.

This study is being conducted to demonstrate the objective utility of the use of pedobarography as a tool to differentiate normal controls from people with spastic gait as well as having utility in objectification of treatment effect on level surfaces and on a ADA based obstacle course.

Eligibility Criteria:
Inclusion Criteria:

* Patients \> 18 years of age
* Must wear shoe size 5½ - 11 US womens or size 6 - 13 US mens
* For treatment group be a clinical patient being treated for lower extremity spasticity

Exclusion Criteria:

* Age matched controls must have no significant neurological or orthopedic disease that would effect their gait
* Clinical patients who are unable to walk for 1 minute
Piloting Treatment With Intranasal Oxytocin in Phelan-McDermid Syndrome

This is a pilot study examining the efficacy, safety and tolerability of intranasal oxytocin as a novel treatment in Phelan-McDermid syndrome (PMS). This study will utilize a randomized, placebo-controlled design for 12 weeks (phase 1), followed by an open-label extension for 12 weeks (phase 2). The purpose is to evaluate the effect of intranasal oxytocin on impairments in attention, social memory, socialization, language, and repetitive behaviors.


Eligibility Criteria:
Inclusion criteria:

* Have a diagnosis of Phelan-McDermid syndrome defined by pathogenic deletion or mutation of the SHANK3 gene and confirmed by chromosomal microarray or sequencing.
* Must be between the ages of 5 and 17
* Must be on stable medication and psychosocial therapy regimens for at least three months prior to enrollment

Exclusion criteria:

* Allergy to oxytocin
* Active cardiovascular disease, epilepsy, or renal disease that is not controlled by medication
* Pregnant, lactating or refuse to practice contraception if sexually active
* Have caretakers who are unable to speak English, be consistently present at visits to report on symptoms, or are otherwise judged unable to comply with the protocol by the study team
* Comorbid conditions such that the patient is too medically compromised to participate
Comparing Maximal and Half-maximal Suction Pressure Applied During Water Exchange in Colonoscopy

This prospective, randomize, controlled trial will compared maximal to half-maximal suction pressure applied during water exchange in patients undergoing minimally sedated colonoscopy. We test the hypothesis that maximal suction pressure is more efficient and causes shorter insertion time.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing minimally sedated colonoscopy performed by YHH

Exclusion Criteria:

* known history of obstructive lesions of the colon,
* allergy to meperidine,
* massive ascites,
* past history of partial colectomy, or
* refusal to provide written informed consent.
Comparison of Two Electrotherapy Methods on Chronic Low Back Pain

The purpose of this study is; to compare the effects of interferential current therapy (IF) applied in addition to conventional physical therapy on pain, functional status and quality of life compared to pulsed electromagnetic field therapy (PEMF) in patients with chronic low back pain.

The low back is the most common region for musculoskeletal pain. Many factors play a role in the etiology of low back pain. A certain etiological factor or pathophysiological mechanism cannot be found in 85-90% of the patients.

Approximately 80% of those living in industrialized countries experience low back pain in some part of their lives. 10% of low back pain becomes chronic. It is believed that 1% of workforce losses are due to low back pain. This type of pain often occurs when the back muscles, tendons and ligaments are exposed to stress or strain. Mechanical back pains are chronic pain that often affects the lower part of the spine and radiates to the gluteal region. Since daily activities such as leaning, turning, lifting, standing and sitting for a long time increase the pain, the intensity of the pain increases during the day.

Interferential current (IF) therapy is obtained from two medium frequency currents and is applied by delivering a low frequency current (for example 20 to 100 Hz) to the tissue.

Pulsed ElectroMagnetic Field (PEMF) therapy, which is among physical therapy methods, is frequently used in the treatment of knee, hip and spine osteoarthritis symptoms. It is thought that magnetic field therapy improves the oxygen utilization of the cells and the erythrocytes release more oxygen under the influence of the magnetic field, thus having a positive effect on the circulatory system

Eligibility Criteria:
Inclusion Criteria:

* Being diagnosed with nonspecific low back pain
* Symptom onset with more than 3 months

Exclusion Criteria:

* History of surgery on low back region
* Structural deformity on the low back region
* Radiculopathy
* Tumor or malignancy
* Any skin condition that prevents usage of electrotherapy
* Having a pace maker or other types of implants on the low back, pelvis and thoracic region
Evaluate the Intestinal Microbiome in Patients With Erosive Gastroesophageal Reflux Disease and in Asymptomatic Healthy Controls

. In this study, we investigated intestinal microbiomes, in individuals with Gastroesophageal Reflux Disease and healthy individuals, using metagenomic techniques.

Background: The pathophysiology of Gastroesophageal Reflux Disease (GERD) involves several mechanisms. Intestinal dysbiosis may influence factors involved in the pathophysiology of Gastroesophageal Reflux Disease, such as changes in gastrointestinal motor patterns and increased intraabdominal pressure due to increased fermentation of non-digestible carbohydrates. However, few studies have focused on assessment of gut microbiome in the GERD. In this study, we investigated intestinal microbiomes, in individuals with Gastroesophageal Reflux Disease and healthy individuals, using metagenomic techniques.

Methods: We performed a study comprising fecal samples of 22 adults, aged 18-60 years: 11 with erosive esophagitis (eight male and three female) and 11 healthy controls (ten male and one female). Microbiome DNA was extracted from stool samples, and polymerase chain reaction amplification was performed using primers for the V4 region of the 16S rRNA gene (16S ribosomal ribonucleic acid). The amplicons were sequenced using the Ion Torrent™ Personal Genome Machine™ platform, and data were analyzed using QIIME™ software version 1.8 (Quantitative Insights Into Microbial Ecology).

Eligibility Criteria:
Inclusion Criteria:

* a confirmed diagnosis of erosive GERD through clinical and endoscopic criteria
* who have not taken omeprazole or any other drug that changes gastric pH in the thirty days prior to the completion of diagnostic tests for GERD and other tests included in the protocol.

Exclusion Criteria:

* Use of antimicrobials or probiotics in the last three months
* Presence of severe and/or extensive atrophic gastritis confirmed histologically
* Comorbidities that could interfere with motility of the gastrointestinal tract (diabetes mellitus, previous stroke, neurological diseases)
* Use of drugs that could interfere with motility of the gastrointestinal tract or salivation (calcium channel blockers, nitrates, anticholinergics, estrogens)
* Bulky hiatal hernia (greater than or equal to 5 cm)
* Los Angeles grade C or D erosive esophagitis
* Long-distance travel in the last 3 months (outside the southeastern region of the country)
* Pregnant or breastfeeding patients
* Previous history of upper digestive tract surgery
* Obesity (body mass index equal to or greater than 30 kg / m2)
* Patient with a consumptive syndrome or malnutrition
* Tobacco use in the last 30 days / Alcohol use (more than 20 g per day, in the last 30 days)
Testing Cognitive Functions in Patients With COPD Using a Driving Simulator

Little is known about the causes and degree of cognitive dysfunction in patients with Chronic Obstructive Pulmonary Disease (COPD), especially their driving abilities. The purpose of the study is to examine the cognitive skills of patients with COPD by using a driving simulator and to examine correlations to factors that may predict cognitive dysfunction in these patients.


Eligibility Criteria:
Inclusion Criteria:

* a diagnosis of COPD (Forced Expiratory Volume in 1 second (FEV1) / Forced Vital Capacity (FVC) \< 0,70)
* no exacerbations within the last 6 weeks
* valid driver's license and having driven a car within the last 3 months

Exclusion Criteria:

* lacking the ability to use the driving simulator
* no valid driver's license
* alcohol abuse (\> 21 units per week)
* a known diagnosis of obstructive sleep apnea
* uncorrected impaired vision or hearing
* unstable ischemic heart disease, left-sided heart failure, severe neurologic diseases, cancer, severe peripheral vascular disease, severe psychiatric diseases, former apoplexia and uncontrolled hypertension, thyroid diseases or diabetes
The Effect of Laparoscopic Splenectomy on Liver Reserve Function for Cirrhosis Patients

In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.

The patients were enrolled according to the research criteria, and collected the general basic information of the patients. After the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy, and the same nursing team performed the nursing after the operation. Then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. During the treatment, the liver reserve function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including TBIL, DBIL, ALB, ALT, INR, PT, Child-Pugh, ascites, prealbumin, ICG-K, ICG-R 15 and ICG-T/2.

Eligibility Criteria:
Inclusion Criteria:

* A clinical, radiological or histologic diagnosis of cirrhosis of any etiology
* Splenomegaly with secondary hypersplenism, Platelet count \< 50\*10\^9/L
* Informed consent to participate in the study

Exclusion Criteria:

* Hepatocellular carcinoma or any other malignancy,
* Child-Pugh grade C
* Recent peptic ulcer disease
* History of Hemorrhagic stroke
* Pregnancy.
* Uncontrolled Hypertension
* Bleeding portal hypertension
* Human immunodeficiency virus (HIV) infection
Formulating Expert Consensus Guidelines in Cancer Care Using the Delphi Method

This study formulates consensus agreement on clinical key elements related to prostate cancer care that are critical for standardization and global reported using a robust Delphi technique, completely remote and electronic. The goal of this survey study is to have a panel of specialty-specific experts create a consensus agreement on a minimum set of key data elements for use in standardized reports. These recommendations would be used to develop standardized methods to report key data in electronic health records to better manage cancer patients at time of diagnosis, treatment, follow up, and into survivorship.

PRIMARY OBJECTIVE:

I. To formulate consensus agreement on a minimum set of clinical key elements that should be included in standardized reports in electronic health records when managing patients with prostate cancer.

OUTLINE:

Participants complete 3-4 rounds of questionnaires over 20-30 minutes each over 2 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Age 21 and above
* Board certification in Radiation Oncology, Radiation Physics, Urology, and/or Medical Oncology
* Maintenance of an active practice that includes prostate cancer patients
* English speaking

Exclusion Criteria:

* Medical providers that are not board certified in the professions and/or those who do not treat prostate cancer
* Prisoners, children, and adults unable to consent to participation will also be excluded
* No exclusions were made based on sex, age, racial/ethnic background, or pregnancy status