cyrilzakka/clinical-trials huggingface dataset:
Rhomboid Flap vs. Deep Suturing in Recurrent Pilonidal Sinus

This prospective clinical trial aims to compare the perioperative outcomes of rhomboid flap versus deep suturing in the management of recurrent sacrococcygeal pilonidal disease.

Pilonidal disease derives its name from Latin- pilus meaning "hair," and nidus meaning "nest" . The source of pilonidal disease is thought to be a deep intergluteal sulcus. It is widely accepted that the establishment of the pilonidal sinus results from the penetration of shed hair shafts through the skin, which ultimately leads to an acute or chronic infected site .

Pilonidal disease is largely considered a surgical disease, especially in acute instances with secondary infection and abscess. Infection or abscess requires incision and drainage. Definitive treatment is delayed the majority of the time if there is an acute infection or abscess until after the infection has been addressed. Surgical options for chronic disease are numerous and can include "pit picking," curettage, aspiration, unroofing, or surgical excision. Defects can be closed primarily, with flaps or grafts, or allowed to heal by secondary intention .

The most serious problem of the various surgical approaches proposed is the recurrence rate, ranging from 0% to 40% .

The surgical treatment of patients with recurrent disease does not differ from the surgical treatment of primary pilonidal disease. In case of a recurrence with an abscess, incision and drainage prevail, while in case of chronic recurrent disease, a flap based procedure may be indicated following sinus excision with scarring, like the rhomboid flap .

Eligibility Criteria:
Inclusion Criteria:

* Adult patients aged between 18 and 60 years;
* Patients with one or two small inactive sinuses will be included for easier excisional procedures;
* Previous intervention for pilonidal disease whether surgical or non-surgical;

Exclusion Criteria:

1 - Patients with an acute abscess. 2- Patients with mall inactive pilonidal sinus disease. 3- Age beyond the previous limits. 4- Patients with primary pilonidal disease. 5- Refusal to participate in the study. 6- Unfit for anaesthesia and surgery. 7- Patients with malignant neoplasms or inflammatory bowel disease.
Severe PID With Lymphoproliferation and Neutropenia

The purpose of this study is to analyse the phenotype in a sub-population of adults with severe primary immunodeficiency with lymphoproliferation and neutropenia and to decipher the possible pathways involved, especially under the hypothesis of a CTLA4/LRBA schema


Eligibility Criteria:
Inclusion Criteria :

* \>18 years old
* CVID (Common Variable Immunodeficiency)
* Neutropenia
* Lymphoproliferation

Exclusion Criteria :

- Secondary immunodeficiency
Observe Intestinal Tract Cleaness of Senile Constipation Patients Used Gastrointestinal External Stimulation

This is a prospective, randomized, double-blind controlled trial. Elderly patients with constipation requiring colonoscopy were randomly divided into four groups: 1. Received both gastrointestinal external stimulation and transcutaneouselectrical acupoint stimulation; 2. Received gastrointestinal external stimulation singly; 3. Received transcutaneouselectrical acupoint stimulation singly; 4. No stimulation was given. All groups received oral administration of polyethylene glycol for intestinal cleansing. Boston Bowel Preparation Scale (BBPS) score was used to assess the quality of intestinal cleanliness , with a total score of 9, and higher scores indicating better intestinal cleanliness, and BBPS≥6 was defined effective.

The early detection of intestinal lesions is extremely important, and the quality of intestine cleanliness is an important factor for the quality of colonoscopy. The elderly are at high risk of intestinal diseases. However, surveys have found that the overall quality of bowel cleanliness in elderly patients undergoing colonoscopy is poor, which affects the detection rate of colon lesions. This is a prospective, randomized, double-blind, controlled clinical trial to observe whether combined gastrointestinal surface stimulation and transcutaneous electrical acupoint stimulation can improve the quality of bowel cleansing and increase the detection rate of intestinal diseases. Elderly patients with constipation requiring colonoscopy were randomly divided into four groups: 1. Received both gastrointestinal external stimulation and transcutaneouselectrical acupoint stimulation; 2. Received gastrointestinal external stimulation singly; 3. Received transcutaneouselectrical acupoint stimulation singly; 4. No stimulation was given. All groups received oral administration of polyethylene glycol for intestinal cleansing. Boston Bowel Preparation Scale (BBPS) score was used to assess the quality of intestinal cleanliness , with a total score of 9, and higher scores indicating better intestinal cleanliness, and BBPS≥6 was defined effective.

Eligibility Criteria:
Inclusion Criteria:

1. Age 60-80 years old;
2. Colonoscopy was planned;
3. The diagnosis of constipation was in accordance with Rome Ⅳ criteria.

Exclusion Criteria:

1. Acute myocardial infarction (within 6 months), severe heart failure (New York Heart Association class II-V, chronic renal failure (CKD stage II-V), or mental disorder;
2. Colorectal resection;
3. Drugs of aspirin, warfarin, or other anticoagulants, and coagulopathy;
4. Oral administration any drugs that may affect gastrointestinal motility, such as proton pump inhibitors, non-steroidal anti-inflammatory drugs or antibiotics (within 4 weeks), probiotics (within 2 weeks);
5. The following diseases：inflammatory bowel disease, frequent diarrhea, severe gastroparesis, intestinal perforation or obstruction;
6. Participating in other clinical trials.
Effectiveness of Wet Needling Technique in Patients of Patellofemoral Pain Syndrome

This study evaluate the effectiveness of wet needling technique in reducing pain, improving function and enhancing the quality of life in patellofemoral pain syndrome patient.Patellofemoral pain syndrome is a common knee condition that significantly affects physical activity and quality of life .

This study aims to determine wether integrating wet needling into a kinesiotaping and strenghthening exercises regimen provides enhanced outcomes for patellofemoral pain syndrome patients .Wet needling combined with kinesiotaping and strengthening eexercises provides superior pain relief and functional improvement .Participant will divided into two groups : one will recieve treatment using wet needling with kinesiotaping and strengthening exercises , and the other recieve kinesiotaping and strengthening exercises.

Eligibility Criteria:
Inclusion Criteria:

* Age between 20-35
* unilateral , prepatellar or retropatellar pain unrelated to trauma for atleast 3 month , agerevated witrh atleast 2 daily activities such as prolonged sitting, squatting , kneeling , running or stairs climbing.
* Positive clarkes sign.
* Average pain in the previous week \>3 on numeric pain rating scale. Kujala questionnaire score \<85of 100.
* Active trigger points in gluets and quadriceps.
* Presence of palpable taut band in muscle and typical reffered pain .

Exclusion Criteria:

* Bilateral anterior knee pain.
* Patients with fracture of knee joint , dislocation of patella , previous knee or ankle surgery and ligament or meniscus injury .
* Marked structural deformity and known pathological condition of back , hip and ankle . Any metabolic or neurological disease such as diabetes or radicular pain . Physical therapy for knee pain within the previous year .
Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients

The purpose of this study is to report the incidence of ventricular arrhythmias correlated to the SAS and to focus on the interest of diagnosing Sleep-disorders breathing in ICD patients. This diagnosis will be assessed by an ambulatory nasal pressure recording with portable multi-channel recorder associated to a complete SAS related symptoms questionnaire.This clinical trial will be the first step to gather information about the suspected sleep relation between ventricular arrhythmias and Sleep breathing disorders, in order to improve the management and treatment of such arrhythmias in next generation of defibrillators which will integrate a minute ventilation sensor able to monitor breathing.


Eligibility Criteria:
Inclusion Criteria:

* Patients who are at risk of sudden death due to ventricular arrhythmia and who satisfy at least one of the following criteria are eligible for enrolment:
* Class I indications for ICD

  * Survival of at least one episode of cardiac arrest due to VT or VF not due to a transient or reversible cause, or presumed to be due to VF when electrophysiological testing is precluded by other medical conditions; or
  * Spontaneous sustained ventricular tachycardia, or
  * Syncope of undetermined origin with clinically relevant haemodynamically significant sustained VT or VF induced at electrophysiological study when drug therapy is ineffective, not tolerated or not preferred, or
* Class IIa Indication for ICD

  * Non-sustained VT with coronary disease, prior myocardial infarction, left ventricular dysfunction (≤ 40%) and inducible VF or sustained VT at electrophysiological study.
  * With prior myocardial infarction and LVEF less than 30 % (without prior life-threatening arrhythmia or sustained VT).
* Patients candidate for cardiac resynchronization therapy (CRT) need to be in functional Class III or IV of the NYHA classification.

Patients will be included only after having granted their informed consent to participate in the study, preceded by the delivery of appropriate information

Exclusion Criteria:

* VT/VF is associated with drug toxicity, electrolyte imbalance, hypoxia, electrocution or other reversible cause;
* VT/VF occurred during the acute phase of infarction (\< 1 week) or during an unstable ischemic phase;
* Incessant VT/VF;
* Implanted pacemaker that is not going to be explanted or otherwise disabled;
* Inability or refusal to provided informed consent
* Tricuspid valvular disease or tricuspid mechanical heart valve (lead contraindication);
* Unable to understand the purpose and plan of the study;
* Geographically unstable or not available for follow-up as defined in the investigational plan;
* Reduced life expectancy (≤ 1 year) for other than cardiovascular reasons;
* Patient participating in another clinical study;
* Patient of minor age (\< 18 years);
* Pregnancy (Women of childbearing potential are required to have a negative pregnancy test within seven days prior to enrollment).
The Effects of Expressive Writing and Compassionate Letter Writing on Emotional Distress Intolerance

Perceived emotional distress intolerance is a transdiagnostic marker of psychopathology associated with psychological and interpersonal dysfunction, and the development of interventions for perceived emotional distress intolerance is of prime importance. One potential intervention is a behavioural experiment, i.e. a cognitive behaviour therapy technique where clients undergo an exercise designed to test a maladaptive belief, e.g., that negative emotions are unbearable, and adjust their belief to accommodate any disconfirmatory information that arises through the exercise. This study examines the effects of a one-session self-compassion writing behavioural experiment compared to a one-session expressive writing behavioural experiment on low perceived distress tolerance. Participants were recruited from the University of Waterloo and Prolific, and were randomly assigned to the self-compassion condition, expressive writing condition, or a control condition.

The study consisted of two online surveys. During the first survey, participants answered a set of questionnaires. Then, they were prompted to think of an upsetting situation and the associated unpleasant emotions, and they were then randomly assigned to a brief self-compassionate writing, expressive writing, or neutral writing task. They then answered a series of questionnaires immediately after completing the writing task. During the second survey, one week later, participants answered a brief set of questionnaires.

Eligibility Criteria:
Inclusion Criteria for University of Waterloo sample:

* Undergraduate students with a SONA account who are high in emotional distress intolerance (i.e. a lower-than-average score on the Distress Tolerance Scale; mean based on SONA student sample)

Inclusion Criteria for Prolific sample:

* Adults with a Prolific account who are high in emotional distress intolerance (i.e. a lower-than-average score on the Distress Tolerance Scale; mean based on Prolific sample)
* First language English speakers

Exclusion Criteria:

* None
Serious Adverse Drug Reaction and Their Preventability

Introduction: Elderly aged over 65 years accounted for around 17.5% of the French general population. Adverse drug reactions (ADR) are common in this population. In elderly subject, prevalence of ADRs ranged from 4.3% to 63.0%.

Aim: To describe the serious ADR in elderly subjects aged over 65 years and assess their preventability.

Methods: A retrospective study was conducted at the Regional Pharmacovigilance Center of Champagne-Ardenne (northeast of France) between January and May 2013. Patients aged over 65 years who presented a serious ADR notified to the Regional Pharmacovigilance Center were included in the study.

Introduction: Elderly aged over 65 years accounted for around 17.5% of the French general population. Adverse drug reactions (ADR) are common in this population. In elderly subject, prevalence of ADRs ranged from 4.3% to 63.0%. Age itself is not a risk factor for ADRs but is a factor of severity of ADR. According to the World Health Organization (WHO), more than half of all ADRs are considered to be preventable in elderly subjects. They are most often the result of a mistake during the prescription phase, or the monitoring phase, or may be due to poor compliance or inappropriate self-medication. Drug prescription is based on guidelines derived from clinical trial that have not included elderly subject with multiple comorbidities. Data regarding drug safety from clinical trials alone are insufficient, hence the need to continue the monitoring of ADR after drug marketing.

Aim: To describe the serious ADR in elderly subjects aged over 65 years and assess their preventability.

Methods: A retrospective study was conducted at the Regional Pharmacovigilance Center of Champagne-Ardenne (northeast of France) between January and May 2013. Patients aged over 65 years who presented a serious ADR notified to the Regional Pharmacovigilance Center were included in the study.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged over 65 years
* Patients who presented a serious adverse drug reaction notified to the Regional Pharmacovigilance Center of Champagne-Ardenne
Exhaustive Genetic and Immunological Characterization of Colon, Kidney and Liver Tumors

Over the last 10 years, technological advances in molecular biology enabled a more accurate genomic characterization of tumors. For each tumor location, this led to the identification of subgroups with similar molecular characteristics. This identification allowed the development of targeted therapies and thus to improve the patient prognosis. This molecular characterization has also revealed the tumor heterogeneity. It may be the cause of treatment resistance and therefore of relapses. Additionally, tumor cells are in constant dialogue with their microenvironment composed of different immune or non immune cells. This microenvironment is now targeted in cancer treatment.

To date, there are few studies that combine a deep genomic characterization of both tumor and tumor microenvironment of the patient. Combining the two types of studies on the same tumor should help to define new therapeutic targets and should allow a combination of targeted and immunomodulatory therapies. To this end, our project is to conduct an exhaustive integrated exploratory analysis at genomic, transcriptomic and immunological levels of 3 tumor types (in colon, kidney and liver cancer).

The design consists in recruiting 50 patients per tumor location (colon, kidney, liver). For colorectal and kidney cancers, a prospective enrollment will be done for patients who have consented to the study. A retrospective enrollment will be done for patients with liver cancer only and who have consented to a national biological resource center form with genetic study approval.

The tumor samples will be taken during surgery. Blood and tumors samples will be taken as part of the treatment.

In case of a accidental germline discovery a management by a genetic consulting will be proposed.

Eligibility Criteria:
Inclusion Criteria:

* for colorectal cancer group : patient with stage III colon carcinoma
* for kidney cancer group : patient with primary clear cell carcinoma more than 4 cm
* for liver cancer group : patient with advanced hepatocellular carcinoma : biopsy or resected BCLC (Barcelona Clinic Liver Cancer) stage B or C
* patients who have consented to the study

Exclusion Criteria:

* Patients receiving neoadjuvant therapy are not eligible
Randomized-controlled Trial of the Effectiveness of COVID-19 Early Treatment in Community

There is an urgent need to identify effective treatments for SARS-CoV-2 infection that helps people recover quicker and reduces the need for hospital admission. The investigators develop an open, adaptive, platform trial to evaluate treatments, Fluvoxamine, Bromhexine, Cyproheptadine, and Niclosamide suitable for use in the community for treating COVID-like-illness that might help people recover sooner and prevent hospitalisation.

There is an urgent need to identify interventions against COVID-19 suitable for wide use in the community that have been proven to be effective in reducing symptom duration or hospitalisation. There is urgent need to know whether potential COVID-19 treatments such as Fluvoxamine, Bromhexine, Cyproheptadine, and Niclosamide that are available for rapid pragmatic evaluation might modify the course of COVID-19 infections, particularly among those who are at higher risk of complications, such as those aged 50 years and over with comorbidity and those aged 65 years and over.

Most reported trials have been conducted in hospital settings, and there is little evidence from community settings, where most people with COVID-19 receive care and where deployment of effective early treatment could speed time to recovery and reduce complications. The investigators established a multi-arm, adaptive platform, randomised controlled trial for community treatment of COVID-19 syndromic illness in people at higher risk of an adverse illness course.

Eligibility Criteria:
Inclusion Criteria:

* COVID-1 9 patients with mild symptoms and the results were confirmed by Antigen Test Kit or PCR for SARS-CoV-2.
* People who have symptoms consistent with COVID-19 and test positive for SARS-CoV-2 infection within 48 hours of being known.
* Participants are 18 years of age or older.

Exclusion Criteria:

* Almost recovered (generally much improved and symptoms now mild or almost absent)
* Judgement of the recruiting clinician deems ineligible.
* Previous randomisation to an arm of the trial
* Pregnancy
* Breastfeeding
* Known severe hepatic impairment.
* Known severe renal impairment.
* Currently taking Fluvoxamine, Bromhexine, Cyproheptadine, or Niclosamide
Scribes in the Emergency Department

This study will evaluate the effect of scribes on an academic emergency department.

This study will be a prospective before-after study with washout period of various performance measures before and after the implementation of ED scribes. We will also collect survey data to measure physician satisfaction and patient perception of scribes.

Eligibility Criteria:
Inclusion Criteria:

* All consecutive patients during the study period
* age \> 18 y/o

Exclusion Criteria:

* Patients seen during the washout period
Cerebral Computed Tomography on Patients With Minor Head Injuries

This observational study aims to calculate the prevalence of conditions or diseases requiring immediate medical attention in CTC scans with an indication of bleeding post trauma performed in the ED at Odense University Hospital. Secondary, we aim to evaluate the Scandinavian Neurotrauma Committee clinical guideline 2013 for minor head injury.

In this retrospective study, our primary objectives are threefold: first, to calculate the prevalence of conditions or diseases requiring immediate medical attention and to subdivide them to explore potential correlations with biochemical, clinical, and patient baseline variables using multiple regression analysis. Secondly, we wanted to analyze our use of SNC CPG and evaluate if a more stringent application could reduce the potentially unnecessary overuse of CTC. Lastly, we aim to evaluate the 30-day mortality and readmission rates to a hospital following CTC performed in the ED.

Eligibility Criteria:
Inclusion Criteria:

* CTCs conducted from 01.01.2023 to 31.12.2023 in the ED

Exclusion Criteria:

* unrelated to trauma
* scans performed on patients under the age of 18
* CTC scans without radiologic interpretation
* Previously undergone a CTC during the same hospitalization, only the first CTC was included
Effectiveness of Unilateral Versus Bilateral Intensive Training in Children With Cerebral Palsy

This 3-year research project aims to investigate and compare the immediate and long-term treatment effectiveness as well as motor improving curve and potential predictors of the unimanual intensive training and bimanual intensive training protocols with an equivalent intervention period in children with hemiplegic CP and children with CP with apparently one side affected. In addition, based on the ICF-CY model, comprehensive outcome measures including motor functions as well as psychological functions will be included.


Eligibility Criteria:
The inclusion criteria of this study are:

1. aged between 3 and 16 years
2. diagnosed with congenital hemiplegic or children with CP with one more affected side; (3) apparently disuse phenomenon of the more affected hand at spontaneous contexts

Participants will be exclude for:

1. excessive muscle tone (Modified Ashworth Scale ≤ 2 at any joints of the upper limb) before beginning treatment (Bohannon \& Smith, 1987)
2. severe cognitive, visual, or auditory disorders according to medical documents, parental reports, and the examiner's clinical observation
3. injections of botulinum toxin type A or operations on the UE within 6 months
SelectSecure 3830 Lead Imaging

This study is designed to collect high-quality shoulder and intracardiac bi-plane fluoroscopic images during two standard arm motions on patients implanted with a market released SelectSecure 3830 lead for the purposes of developing a fracture reliability model.


Eligibility Criteria:
Inclusion Criteria:

* Patients who are at least 18 years of age
* Patient has a pacing, ICD or CRT system incorporating at least one SelectSecure 3830 lead in the right atrium or right ventricle
* Patients able and willing to attend imaging session
* Patients able and willing to give informed consent
* Pacing capture threshold and pacing impedance of the lead are within normal range at the time of enrollment
* Patient must be able to accomplish arm flexion and adduction past 90 degrees

Exclusion Criteria:

* Subjects who require a legally authorized representative to obtain consent
* Subjects with exclusion criteria required by local law (e.g. age, breastfeeding)
* Pregnant women, or women of child bearing potential and who are not on a reliable form of birth control
* Subjects that were implanted with a pacing, ICD, CRT device and/or cardiac leads less than three months ago