cyrilzakka/clinical-trials huggingface dataset:
Efficacy of Distilled Water Versus Mitomycin C on Preventing Recurrences of Bladder Cancer After Transurethral Resection

The purpose of this study is to compare and evaluate the efficacy of distilled water vs Mitomycin C on preventing the recurrences of intermediate risk group recurrent superficial bladder cancer administered as a single dose immediate instillation after complete Transurethral Resection(TUR) of the tumor.

We plan to administer 200ml of distilled water as a single peroperative instillation and block the catheter for 2 hours to our eligible recurrent superficial bladder cancer patients who were in our follow-up schedule since 2002.

We plan to look over the histories of the same patients in terms of the pathologies, recurrence patterns, the presence of peroperative intracavitary therapy after their previous TURs for recurrences.

So we shall compare the effectiveness of MMC and distilled water on reducing the recurrences over the same patient pool.

The patients will be scheduled for a follow-up program after TUR as;

* cystoscopy
* urine cytology
* bladder wash cytology for the probability of recurrence for 2 years to see if there is any difference in the recurrence patterns after instillation with distilled water vs MMC.

Eligibility Criteria:
Inclusion Criteria:

* pathologic finding of superficial bladder cancer within the intermediate risk group
* recurred after 6 months from the primary tumor
* those patients who were included in our follow-up program since 2002 and whose records could be obtained.

Exclusion Criteria:

* carcinoma in situ
* any form of intracavitary maintenance therapy
* any form of bladder cancer other than transitional cell type
Kinesio-Taping and Chest Physiotherapy Program After Mastectomy

The modified radical mastectomy (MRM) is a major surgical approach that necessitates the dissection of axillary lymph nodes. As a result, there is more bleeding and the treatment takes longer time. This treatment is used to treat locally advanced breast cancer. Numerous factors, including pain and respiratory depression from general anaesthesia, can impair respiratory function during the post-operative period. Pain causes the thoracic cage's post-operative movement to be restricted and the breathing muscles to become inhibited.

KT is a new technology that is being used in the treatment of post-surgical and respiratory problems, among other innovative evidence-based therapeutic options in patient care. Recently, this method is useful for treating a variety of sports-related and musculoskeletal disorders, as well as pain management. According to a small body of research on the usefulness and efficacy of KT in treating respiratory conditions in patients with chronic obstructive pulmonary disease (COPD), it can lead to improvements in respiratory muscle strength and pulmonary function.

Eligibility Criteria:
Inclusion Criteria:

* Females aged between 30 and 50 years
* Participants after modified radical mastectomy
* Participants able to comprehend instructions.
* Cooperative participants, and willing to participate in the study.

Exclusion Criteria:

* Participants having sensitive skin, scars, or lesions.
* Participants with unhealed incisions at the site of application.
* Participants with uncontrolled diabetes.
* Participants with deep vein thrombosis.
* Participants with previous chest diseases.
* Pregnancy.
* Participants with altered sensations.
* Participants with allodynia.
* Participants with active infection.
Prevalence of Coronal Femoral Bowing in the Egyptian Arthritic Knee

To Detect the Prevalence Of Coronal Femoral Bowing in Egyptian arthritic knee. The restoration of normal coronal alignment of the lower extremity is very important to surgeons who perform reconstructive surgery of the knee, such as total knee arthroplasty (TKA). The importance of achieving normal coronal alignment of the lower extremity after TKA is widely recognized . TKAs with coronal malalignment tend to fail earlier than those with neutral alignment. 8 Coronal alignment is considered key to the function and longevity of a TKA. However, most studies do not consider femoral and tibial anatomical features such as coronal femoral bowing and the effects of these features and subsequent alignment on function after TKA are unclear investigators therefore determined the prevalence of coronal femoral bowing, femoral condylar orientation (mLDFA ) , and tibia plateau inclination (mMPTA ) in osteoarthritic Egyptian population

Radiological methods :

1) standing anteroposterior radiographs of the full-length lower limb with patients in the standing position. ( HKA Long Film Radiographs ).

Measurements :

1. mechanical hip-knee-ankle axis (HKA) angle: the angle formed by the mechanical axes of the femur and tibia
2. anatomical hip-knee-ankle axis (HKA) angle: the angle formed by the anatomical axes of the femur and tibia
3. For condylar orientation : the mechanical lateral distal femoral angle (mLDFA) was defined as an angle formed by the mechanical axis of the femur and the line connecting the distal ends of the medial and lateral femoral condyles of the femur.
4. For tibia plateau inclination : the mechanical lateral proximal tibial angle (mLPTA) was defined as an angle formed by the mechanical axis of the tibia and the articular surface of the proximal tibia .
5. Coronal femoral bowing Using the method of Yau et al. : the femoral diaphysis was divided into four equal parts, . Because Yau et al. didn't exactly describe the femoral diaphysis, we had defined the femoral diaphysis from the lower border of the lesser trochanter to upper border of the distal femoral segment which is defined by a square whose sides have the same length as the widest part of the femoral condyle so called rule of square (from the lowest level of the lesser trochanter to 5 cm above the lowest level of the lateral femoral condyle), and the midpoint of the endosteal intramedullary canal was depicted in each quarter. The angulation between midlines drawn in the proximal and distal quarters of the femoral diaphysis will be measured

Eligibility Criteria:
Inclusion Criteria:

-Any advanced Osteoarthritic patient schedual for TKA

Exclusion Criteria:

* History of femoral or tibial fracture or osteotomy around the knee .
* Presence of a congenital anomaly in the femur or tibia .
* History of prior knee or hip arthroplasty .
* Diagnosis other than primary osteoarthritis (RA-inflmmatory arthritis..etc) .
* Position in radiographs preventing complete evaluation of radiographic variables .
Exercise Test and Cardiac Injury

Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply that mimic those of ischemia and reperfusion injury. If the mechanism underlying the troponin release during exercise is similar to that of ischemia reperfusion injury (IRI), than it should be susceptible to remote ischemic preconditioning (RIPC) as RIPC is a well validated technique to reduce IRI. To test this hypothesis healthy volunteers underwent a strenuous exercise test with or without preceding RIPC.


Eligibility Criteria:
Inclusion Criteria:

* age: 18-45 year
* willing to sign informed consent
* healthy

Exclusion Criteria:

* hypertension (systolic blood pressure \>140 mmHg or diastolic blood pressure \> 90 mmHg)
* any cardiovascular abnormality in past medical history, physical examination or ECG, including QTc interval
* drug abuse
* alcohol abuse (\> 3 units/day)
* smoking during the last 2 years
* BMI \>30 kg/m2
* inability to perform bicycle test
* the presence of an absolute or relative contra-indication for exercise (table 2 in protocol)
* the presence of diabetes (fasting glucose \> 6.9 mmol/L, non-fasting glucose \>11.0 mmol/L; if non-fasting glucose is \> 6.9 mmol/L, blood glucose measurement will be repeated in fasting condition and should then not exceed 6.9 mmol/L)
* total cholesterol in blood 6.6 mmol/L or higher
A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning

This prospective, multi-center, randomized controlled study aims to assess the efficacy of utilizing 3D printed models in preoperative planning for the excision of tumors involving bony structures within the body. The study is expected to last approximately 12 months and involve up to 150 subjects across 3 sites. Subjects will be randomized in a 1:1 ratio into either the experimental arm, utilizing 3D printed models and imaging, or the active comparator arm, using only imaging.

Primary endpoint: Operative time of surgical procedure.

Secondary endpoints: Reduction of blood loss, proportion of postoperative adverse events, and negative tumor margins.

Exploratory endpoints: Surgical planning ease, changes in surgical plan, and surgeon satisfaction.


Eligibility Criteria:
Inclusion Criteria:

1. Subjects must be at least 22 years of age.
2. Subjects must have the ability to provide written informed consent.
3. Subjects must have tumor(s) invading bone and requiring surgical excision including but not limited to craniomaxillofacial, spine, long bone, and pelvis.
4. Subjects must be willing to have quality cross-sectional imaging that will allow for use to develop a 3D printed model.

Exclusion Criteria:

1. Pregnant or nursing women.
2. Subjects that have a serious systemic pathology.
3. Subjects that have clotting disorders.
4. Subjects that have uncontrolled hypertension.
5. Subjects that are HIV-positive.
6. Subjects that are unable to be randomized; i.e surgical team prefers to use either 3D model or standard cross-sectional imaging for surgical pre-planning.
7. Subject anatomy has changed substantially since the date medical imaging from which the model is derived was obtained (as applicable).
8. Subject is a poor surgical or poor study candidate which may include, any medical, social or psychological problem that could complicate the procedure.
Effects of Propofol and Ketofol on Core Body Temperature in MRI

Investigators researched the effect of two different types of drugs on core body temperature during magnetic resonance imaging. The hypothesis is in ketamine group, thermo disregulation is not as distinct as in propofol group, due to its positive effect on thermo regulation

Intravenous anesthetics may impair thermoregulation. Absorption of radiofrequency waves by the body surface may result in heating, especially in small children during magnetic resonance imaging (MRI). Investigators applied two different intravenous anesthetics as propofol and ketamine and studied the effect of these drugs on core body temperature.

All patients aged between 6 months-10 years were administered midazolam and atropine. After that 1 mg/ kg of propofol was applied in group I, and 0,1 ml/kg of propofol ketamine mixture ( 10 mg/ml each) was applied in group II. Core body temperatures were taken before and after MRI and compared.

Eligibility Criteria:
Inclusion Criteria:

* children aged between 6 months-10 years,
* underwent MRI under anesthesia
* ASA I-II

Exclusion Criteria:

* History of drug allergy
* Severe pulmonary and cardiac disease
* Intracranial hypertension
Trial for Reliability of Urodynamics SysTem

The goal of this prospective trial is to assess the safety and reliability of the Glean Urodynamics System (GUS) in adult females with lower urinary tract symptoms. The main question\[s\] it aims to answer are:

• What is GUS's ability to safely and reliably conduct wireless, catheter-free monitoring of vesical pressure compared to the vesical pressures collected with conventional urodynamics?

Participants will undergo a conventional urodynamics exam, a simultaneous urodynamics exam with GUS, ambulatory urodynamics with GUS, and extended home monitoring with GUS.

Researchers will compare GUS data with that from a conventional urodynamics exam.


Eligibility Criteria:
Inclusion Criteria:

1. Female patient must be ≥ 18 years of age
2. Patient is a candidate for urodynamics per standard of care
3. Patient or patient's legally authorized representative is able to provide informed consent

Exclusion Criteria:

1. Pregnant (as confirmed by urine pregnancy test or medical history) or breastfeeding, pregnant within the past 6 months or intend to become pregnant during the study period
2. Patient has one or more symptoms indicative of a urinary tract infection (UTI) (i.e., fever, costovertebral angle pain or tenderness, suprapubic tenderness, worsening urinary frequency, worsening urgency, and/or dysuria).
3. Patient has history of recurrent UTIs (≥ 3 episodes in previous 12 months).
4. Patient has used antibiotics within the past 7 days from the baseline/screening visit.
5. Patient diagnosed with neurogenic LUTS (which may be associated with one or more of these conditions: normal-pressure hydrocephalus, cerebral palsy, spinal cord injuries, traumatic brain injury, stroke, Parkinson's disease, multiple sclerosis, meningomyelocele, spina bifida, dementia, Guillain-Barre syndrome, and tumors involving the central nervous systems or spine).
6. Patient diagnosed with interstitial cystitis (IC), bladder pain syndrome, painful bladder syndrome or any etiology of chronic pelvic pain syndrome (CPPS).
7. Patient with a urostomy.
8. Patient has an atypical anatomic structural variation or has had a previous surgical intervention that has permanently changed structural anatomy anywhere along their lower urinary tract (urethra, pelvic floor, urethral sphincter, and/or bladder wall).
9. Patient who has from one or more major strictures in the urethra.
10. Patient has a Pelvic Organ Prolapse Quantification (POP-Q) of Grade III or higher (i.e., most distal portion of the prolapse protrudes more than 1 centimeter below the hymen).
11. Patient with a colostomy.
12. Patient with any abnormal or concerning rectal or vaginal conditions such as ongoing anal fissures, rectocele, fistula, active herpes, active yeast infections, or vaginitis.
13. Patient has a known inability to void or is in complete retention.
14. Subjects who, at the principal investigator's determination, would not be appropriate for this study
Sensory Integration Disorders in Patients With MS Including Disease Advancement and Relapses in the Last Year

the aim of the study was to assess the occurrence of sensory integration disorders in people with SI depending on the stage of the disease and relapses in the last year;analysis of sensory integration disorders in patients with Ms and healthy people

141 patients diagnosed with RRSM were enrolled in the study. The control group consisted of 72 healthy people. The Sensory Integration Assessment Scale in Adults (SPD) was used to test sensory integration, and an original questionnaire was carried out containing information on age, gender, frequency of relapses in the last year, and duration of the disease.

Eligibility Criteria:
Inclusion Criteria:

* health of a person
* aged 30-45 years
* without diagnosed disorders of sensory integration and MS

Exclusion Criteria:

* diagnosed disorders of sensory integration
* diagnosed with Ms
The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery

In cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin C concentration is sharply decreased. The anti-inflammatory and anti-oxidant effects of vitamin C and the effects of reducing vasoconstrictor use have been demonstrated in patients with sepsis and septic shock, however, the foregoing effects have not been validated in patients undergoing cardiac surgery.

In this study, investigators investigate the effect of intravenous vitamin C on the incidence of acute renal injury after valvular heart surgery.


Eligibility Criteria:
Inclusion Criteria:

* Patients older than 20 years and undergoing elective valvular heart surgery whose preoperative acute renal failure score is ≥3 (moderate to severe risk).

Exclusion Criteria:

* Emergency operation
* Cardiogenic shock or ventricular-assist device (eg. ECMO, IABP)
* Severe chronic kidney disease (GFR(CKD-EPI) \<30ml/min/1.73m2)
* Patients with past history of gout or renal stone or hyperoxaluria or cystinuria
* Hemolytic anemia due to pyruvate kinase deficiency or glucose-6-phosphate dehydrogenase deficiency
* Sicklemia or thalassemia
* Hemochromatosis
* Allergy to disodium ethylenediamine-tetraacetate or ascorbic acid
* Patients taking aspirin up to 3 days before surgery
* Patients taking antiepileptic drug or fluphenazine or steroid
* Patients taking vitamin C within a month of surgery
* Pregnant or lactating women
* Patients who cannot understand the informed consent (eg. Foreigner)
Study In Subjects With COPD (Chronic Obstructive Pulmonary Disease)

This study was designed to determine if the investigational drug is effective and safe in individuals with COPD (chronic pulmonary disease)


Eligibility Criteria:
Inclusion criteria:

* Diagnosis of COPD and a history of cigarette smoking.

Exclusion criteria:

* Significant heart or lung disease not associated with COPD.
* Significant stomach or intestinal disease.
Safety & Performance Randomized Study of the CiTop™ Guidewire for Peripheral CTO

The main objectives of the study are:

To evaluate the performance and safety of the CiTop guidewire, while attempting to cross thru total occlusions of various dimensions and morphology.

To compare the safety and efficacy of the CiTop guidewire with standard guidewires in terms of impact on the treated artery. Following operation of the CiTop device, angiography demonstrated successful crossing of the occlusion with no visible evidence of arterial wall injury, dissection, or distal embolization.

To assess ease of operation and the level of integration of the CiTop with standard interventional angiography procedure: Balloon angioplasty, placement of stent.


Eligibility Criteria:
Clinical Inclusion Criteria:

* Patient with symptomatic peripheral vascular disease, intermittent claudication less than 30 meters, rest pain or tissue ischemia.(Fontain grade 3-4)
* Critical limb Ischemia
* The patient has Chronic Total Occlusion in limb arteries, aged at least 3 months.
* Patient has chronic total occlusion (CTO) that is:
* Documented angiographically, by the investigator or co-investigator.
* CTO was defined as an obstruction of a main peripheral artery with no luminal continuity and with TIMI (Thrombolysis In Myocardial Infraction) flow grade of 0 or 1.
* CTO location suitable for endovascular treatment (not in parallel location with the hip or knee joints).
* Lesion ≤ 8cm in length
* Lesion located in a segment with diameter more than 1.5 mm
* Adequate compliance with follow-up and/or repeat angiography
* No Contra-indication to treatment with aspirin or ticlopidine or clopidogrel and/or Heparin
* Visible entry point of target lesion
* NO cancer or other life threatening diseases or conditions
* NO diagnosis or suspected renal failure (2 x ULN of creatinine)
* Not suspected intolerance of the contrast agent
* NO Drug abuse or alcoholism
* Patients is NOT under custodial care
* Women with childbearing potential are NOT pregnant (positive pregnancy test at the time of procedure).
Propranolol in Severely Burned Children

To determine the safety and efficacy of administration of propranolol for reducing heart rate and blood pressure in burn injury.

Other purposes of this study are to study the effect on muscle function, the infectious process, sepsis, systemic inflammation and long-term scarring. Quality of life will also be looked at over time.

Eligibility Criteria:
Inclusion Criteria:

* Burns covering \>20% of the total body surface are
* Age of 0 to 18 years
* Patient arrival to the burn center within 96 hours (4 days) of burn injury
* Require \> 1 surgical procedure

Exclusion Criteria:

* Pregnancy
* Known history of AIDS, Aids Related Complex, or HIV
* History of cancer within 5 years
* Existence of pre-morbid conditions
* Asthma
* Congestive heart failure (measured ejection fraction \< 20%)
* Medical condition requiring glucocorticoid treatment
* Burn injury due to chemical burns
* Burn injury due to deep electrical injury (decision of hospital PI)
* Presence of anoxic brain injury that is not expected to result in complete recovery
* Decision not to treat due to burn injury severity
MonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in Psychiatry

Mental health disorders, with a 30% annual prevalence rate, are a leading cause of disability and reduced life expectancy. Despite their impact, patient-reported experience measures (PREMs) and outcome measures (PROMs) are underutilized in psychiatry. MonPsy\&Moi®, a digital platform funded by ATIH and DGOS, addresses this gap by providing a user-friendly tool to assess patient experiences and outcomes in real-time, aiming to improve the quality of psychiatric care across France.

The study consists of two stages:

Stage 1 (No Feedback): MonPsy\&Moi® is deployed across 12 psychiatric facilities, collecting patient data without feedback to clinicians. Objectives include assessing implementation feasibility, validating adaptive questionnaires (PREMIUM), and identifying predictors of patient outcomes, such as relapse and healthcare utilization.

Stage 2 (With Feedback): Focuses on patients with severe mental illnesses (schizophrenia, bipolar disorders, and major depressive disorders). This stage evaluates the impact of providing PREMs/PROMs feedback to clinicians on relapse rates, healthcare costs, and overall patient outcomes.

MonPsy\&Moi® uses adaptive questionnaires tailored to psychiatric care, covering key domains such as dignity, information, interpersonal relationships, care environment, and treatment. It also evaluates health-related quality of life, including psychological well-being, autonomy, self-esteem, and social relationships. The platform integrates with national healthcare databases (SNDS) to enhance data analysis and predict patient trajectories.

The study will involve over 22,000 participants in Stage 1 and 1,100 participants in Stage 2, using a quasi-experimental design to compare feedback and non-feedback strategies. Results aim to demonstrate the feasibility, acceptability, and efficacy of MonPsy\&Moi® in improving mental health outcomes and guiding national psychiatric care policies.

By empowering patients and clinicians with actionable insights, MonPsy\&Moi® aspires to set a new standard for patient-centered mental healthcare in real-world settings


Eligibility Criteria:
Inclusion Criteria:

* Residing in France. Age between 18 and 65 years at the time of inclusion.

Receiving care in one of the 12 participating psychiatric facilities, with a confirmed diagnosis of:

Schizophrenia Spectrum Disorders (e.g., schizophrenia, schizoaffective disorder).

Bipolar Disorders. Major Depressive Disorders. A valid email address. Ability to read and understand French. Non-opposition to participating in the study (based on informed consent).

Exclusion Criteria:

* Primary diagnosis of an organic mental disorder, including:

Dementia. Stroke. Traumatic brain injury. Individuals deprived of liberty by judicial decision (e.g., incarcerated patients).