cyrilzakka/clinical-trials huggingface dataset:
Effect of Umbilical Cord Milking on Iron Related Health Outcomes for Cesarean-Delivered Infants

This study aims to determine whether umbilical cord milking can improve iron related health outcomes for cesarean-delivered infants. Half of participants will receive umbilical cord milking, while the other half will receive routine clinical treatment and care.

In recent years, several professional organizations have recommended delayed cord clamping to improve placental transfusion for newborns born vaginally based on a series of randomized controlled studies. However, no similar recommendations are available for cesarean-delivered infants. Investigators found that cesarean-delivered infants were more vulnerable to iron deficiency and anemia compared with those born vaginally, suggesting that it is urgently needed to find a similar anemia prevention strategy for infants born by cesarean sections.

In this study, investigators aim to test whether umbilical cord milking (UCM), a potentially promising strategy for cesarean delivery, can improve iron related health outcomes for cesarean-delivered infants. A total of 450 term pregnant women who are planning to give births by cesarean sections will be enrolled from two hospitals in Hunan province and randomly assigned to either UCM group or control group. Infants will be followed up at 1, 6, 12, 18 months for the evaluation of the impact of UCM on iron deficiency, anemia, as well as growth and the developmental status of language and mental/behavioral outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Singleton pregnancy
* Full-term pregnancy (no less than 37 gestational weeks)
* Cesarean section before the labor starts or cesarean section after the labor starts but with cervix less than 3 cm
* Plan to take vaccines and receive routine child health care in the hospital where she gives birth

Exclusion Criteria:

* Maternal hypertensive disorder
* Gestational diabetes with macrosomia
* Gestational diabetes with polyhydramnios
* Maternal severe anemia with hemoglobin less than 70 g/L
* Maternal coagulation disorders
* Fetal growth restriction
* Major congenital anomalies
* Hemolytic disease of the newborn or hydrops fetalis
* Short umbilical cord length (\< 30 cm)
* Severe cord or placenta abnormalities such as cord prolapse, true knots, placental abruption and placenta previa
* Other conditions that are not suitable for the study judged by the doctors
Prediction of Outcome by Echocardiography in Left Bundle Branch Block

Patients with left bundle branch block have an increased risk for the development of heart-failure and death. However, risk factors for unfavorable outcomes are still poorly defined. This study aims to identify echocardiographic parameters and ECG characteristics by machine learning in order to develop individual risk assessment

The project investigates patients with left bundle branch block (LBBB) which describes a specific block in the electrical conduction system, where the electrical impulses must follow a detour, with the result that different parts of the heart-muscle do not contract at the same time. This condition is called left ventricular dyssynchrony. LBBB can be found in people who are otherwise completely healthy and need not have any practical consequences. In others LBBB is present in patients with different heart diseases such as after myocardial infarctions or other diseases involving the heart-muscle. Patients with implanted pacemakers have a similar failure in the conduction system. Both conditions can increase the risk for development of heart-failure and cardiovascular death. Dyssynchrony can be treated with a special pacemaker (cardiac resynchronisation therapy, CRT) in addition to regular medical treatment. The therapy is well established and has shown to reduce morbidity and mortality and even reverse heart-failure in some patients completely. However, the patients in need and responding to CRT treatment is still not optimally defined. New echocardiographic parameters based on strain imaging such as regional myocardial work are able quantify the degree of dyssynchrony and give new insights into the interplay of activation delay through the LBBB and loading conditions and weakness of the myocardium due to other diseases. These new and complex measures can be integrated with clinical information by machine learning (ML) as a promising tools for accurate patient selection for CRT. The project aims to find markers on ultrasound improved by ML based selection to distinguish those patients who have problems associated with the branch block from those who remain stable. This will facilitate both, an optimized patient selection for CRT treatment and follow-up schedule for those who have a stable condition.

Eligibility Criteria:
Inclusion Criteria:

* QRS complex \>130 ms and R-wave duration in
* V6 \>70 ms
* ventricular pacing\>50%
* Previously implanted cardiac resynchronisation therapy (CRT)

Exclusion Criteria:

* Typical right bundle branch block.
* No ability to give informed consent,
* non-cardiovascular co-mobidities with reduced life-expectancy \< 1 year
* patients with complex congenital heart disease.
Frequency Analysis of Coronary Artery Disease

The purpose of this study is to determine if coronary artery disease can be detected using an electronic, acoustic recording instrument. The presence or absence of abnormal pathology will be confirmed by diagnostic angiography as part of the normal patient care at this institution.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18-89 years old and recommended for a cardiology related angiogram within 24 hours

Exclusion Criteria:

* Any patient less than 18 years of age or greater than 89 years of age.
* Any patient with any of the following conditions: pregnant or nursing, prior myocardial infarction, left ventricular device, heart transplant, valve replacement, congestive heart failure, atrial fibrillation (non-intermittent), endocarditis or any heart viral or bacterial infection, any patient who has or requires medication or other heart rhythm altering treatment.
Efficacy and Safety of Baclofen for Maintenance of Abstinence in Alcohol Dependent Patients

The purpose of the study is to assess the efficacy of Xylka® (baclofen) compared to placebo on continuous abstinence rate during 20 weeks of treatment, after withdrawal, in alcohol dependent patients receiving Brenda therapy sessions.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients meeting DSM IV(Diagnosis and Statistical Manual of Mental Disorders, 4th edition) criteria for alcohol dependence
* Willing to participate in the study and express a desire to achieve the objective of continuous and long term abstinence after withdrawal
* Abstinent (last drinking) for a minimum of 3 days and maximum of 14 days
* At least one previous abstinence attempt

Exclusion Criteria:

* Need for a stay at the end of the withdrawal period in a health care and rehabilitation institution specialized in addiction
* Need for a heavy psychosocial out of hospital care
* History of baclofen intake, by prescription or self medication
* Porphyria
* Concomitant treatment with one or several drugs for the maintenance of abstinence
* Severe renal, cardiac or pulmonary disorder
* Epilepsy or history of epilepsy
* Concomitant treatment with psychotropic drugs, except antidepressants at stable dose for 2 months, diazepam and oxazepam
* Severe psychiatric disease (schizophrenia and bipolar disorder)
* Suicidal risk or history of suicide
* Clinically significant cognitive disorders
* Hepatic encephalopathy
* Ongoing dependence or within the last 12 months on other addictive substances (opioid, cocaine, cannabis, other substances or drugs...), excepted tobacco
Omics Gaucher Study: Multiomic Approach

The study aims to investigate the transcriptomic and metabolomic changes in blood, plasma and isolated monocytes from Gaucher patients and healthy controls.

Gaucher disease is one of the most common lysosomal storage disorders (LSD) and is an autosomal recessive inherited disorder, primed by mutation in the GBA1 gene which leads to a deficiency in β-glucocerebrosidase (GCase) activity and accumulation of its substrate glucosylceramide (GluCer)/-sphingosine (GluSph). The macrophages are the main cell type exhibiting a Gaucher disease phenotype. The large accumulation of GluCer and to a lesser extent that of GluSph lead to dysfunction in organs such as spleen, liver, bone marrow, and lungs.

However, a validated, reproducible, and broadly applicable tool to classify Gaucher Disease at any stage of the disease is still missing.

The development of new technologies, such as genomic analysis by next generation sequencing (NGS) and other "omics technologies," has advanced the molecular understanding and diagnosis of Rare Diseases

The current study will analyze the transcriptional and metabolomic profiles in blood, plasma and isolated monocytes from Gaucher patients and healthy controls with the aim to compare these profiles and to define how much a patient profile differs from a healthy one.

Eligibility Criteria:
Inclusion Criteria:

Gaucher Type 1 participants:

* Informed consent
* The participant is older than 18 years old
* The participant was diagnosed with Gaucher Type 1 disease

Gaucher Type 3 participants:

* Informed consent
* The participant is older than 18 years old
* The participant was diagnosed with Gaucher type 3 disease

Healthy participants:

* Informed consent
* The participant is older than 18 years old
* Healthy participants

Exclusion Criteria:

Gaucher Type I participants:

* The participant had any other clinically significant disease
* The participant had a recent (within 14 days) acute infection and/or vaccination

Gaucher Type 3 participants:

* Diagnosis of a significant CNS disease or cardiovascular disease other than Gaucher type 3
* The participant had a recent (within 14 days) acute infection and/or vaccination

Healthy participants:

* The participant had a recent (within 14 days) acute infection and/or vaccination
NB-UVB Phototherapy With and Without Topical LCD Treatment: a Bilateral Pilot Study

The purpose of this study is to determine if combining a daily at-home regimen using an LCD Solution with a 3 times weekly outpatient narrowband UVB phototherapy regimen could be a safe, effective, rapid, and, convenient treatment for plaque psoriasis.

Use of coal tar with narrowband (NB) ultraviolet B (UVB) light (the Goeckermen regimen) is an effective treatment for plaque psoriasis that has become impractical in outpatient care mainly due to the inconvenience and aesthetic concerns of coal tar. This study aims to evaluate the safety, efficacy, and convenience of adding a novel liquor carbonis distillate (LCD) (coal tar) solution to standard NB_UVB phototherapy in adults with chronic plaque psoriasis. Patients will apply LCD solution to half the body, twice daily at home and receive outpatient full-body NB-UVB light therapy 3 times a week for up to 12 weeks. A blinded investigator will grade psoriasis severity of body halves and bilateral target lesions and monitor adverse reactions. Patients will rate their psoriasis symptoms and LCD solution aesthetics. Incorporating an at-home regimen with a novel LCD solution into outpatient NB-UVB light therapy is safe, convenient, and effective and can improve psoriasis more quickly than NB-UVB light therapy alone.

Eligibility Criteria:
Inclusion Criteria:

* 18 years old or older
* able and willing to provide written informed consent
* symmetrical plaque psoriasis
* able and willing to attend phototherapy sessions and apply LCD at home
* negative pregnancy test for women of child-bearing potential

Exclusion Criteria:

* current or recent other treatments for psoriasis
* hypersensitivity to LCD or UVB light
* current or previous skin cancer
* pregnant or nursing mother
* participating in another clinical trial
Validation of the Screen of Cancer Survivorship - Occupational Therapy Services (SOCS-OTS) Tool for Use in a Physical Medicine Rehabilitation Clinic

To compare the results of the SOCS-OTS to another standardized screening measure that is currently being used by rehabilitation services at MD Anderson Cancer Center and to ensure that the SOCS-OTS correctly identifies those individuals needing OT services in cancer care.

Primary Aim

1. Explore the SOCS-OTS for use in the Physical Medicine and Rehabilitation (PM\&R) clinic by means of diagnostic testing including sensitivity and specificity.

Secondary Aims

1. Explore whether the SOCS-OTS identifies the likelihood that the presence or absence of OT referral is correctly predicted. To accomplish this, the likelihood ratios, and predictive values of the SOCS-OTS will be assessed.
2. Determine associations between the need for OT and demographic factors such as stage of cancer, cancer treatment etc.
3. Establish test-retest reliability of the SOCS-OTS.

Eligibility Criteria:
Inclusion Criteria:

1. Must be 18 years an older
2. Currently medically followed in the PMR clinic (with or without acute disease)
3. Must speak and read English. The AM-PAC is currently validated in adults only. Additionally, the assessment tools are in English without translation into other languages, therefore only clients who do speak and read English will be included. Pregnant participants are not excluded.

Exclusion Criteria:

1. Potential participants with confusion and cognitive impairments that might hinder their ability to sign an informed consent form or participate in the study.
Predictive Multimodal MRI Factors in Subacute Cerebral Artery Occlusiontreated by Thrombectomy (PIMISUTT)

Our study aims to measure metabolic and functional parameters of the infarcted territory by multimodal cerebral MRI in patients diagnosed with unilateral proximal occlusion of the middle cerebral artery and treated by thrombectomy in order to correlate those parameters to clinical outcome (evaluated by modified Rankin score) at 3 months.

We aim to find early radiologic predictive factors for favorable clinical outcome in this population of patients.

The treatment of acute ischemic stroke in the setting of intracranial large artery occlusion and especially middle cerebral artery occlusion (MCAO) with intravenous tissue plasminogen activator (IV-tPA) is associated with low rates of recanalization and high rates of neurological morbidity and functional dependence.

In the last few years, endovascular intervention (mechanical thrombectomy) has proven its safety and its efficacy on clinical outcome in patients diagnosed with MCAO and is now commonly recommended.

However, in this population of patients treated by thrombectomy, very few predictive factors, except for the post-procedural recanalization score (TICI), do exist to foresee the variability of clinical outcome.

Tissue viability of the infarcted territory can be approached by the measure of metabolic and morphological parameters (Na+, H+, phosphore, diffusion imaging) which can be non-invasively done by multimodal MRI, as suggest by recently published studies.

Our study plans to measure these parameters between 12 and 24 hours after acute ischemic stroke in patients with MCAO treated by thrombectomy in order to correlate those parameters to clinical outcome at 3 months (modifier Rankin Score).

Eligibility Criteria:
Inclusion Criteria:

* Patients aged ≥ 18 years old
* Hospitalized at the Poitiers University Hospital
* Acute middle cerebral artery occlusion diagnosed by CT-scan or MRI
* NIHSS score ≥ 6 at admission
* To be treated by thrombectomy with or without fibrinolysis
* Written information delivered to the patient or his relatives concerning the study and its benefit and risk

Exclusion Criteria:

* Patients or relatives whom a loyal information about the study cannot be given
* Patient with cognitive impairments before MRI.
* Patients who cannot undergo MRI because of contraindications
* Patients too deteriorated to tolerate one hour long exam
Quality of Life and Cancers in Nursing Homes

Quality of life (QOL) of nursing homes residents with cancer in France is not known. High prevalence of neurodegenerative diseases makes it difficult. It was found that oncological management is suboptimal among Poitevin territory residents. Publications report an inadequate management of symptoms of discomfort related to cancers.

The multicentric study will comparate quality of life in patients with and without Cancers in nursing homes, including residents with neurodegenerative disease, using validated questionnaires. These questionnaires, as well as pain evaluation, will be carried out by a geriatric consultations' nurse.

Investigators will also make a descriptive inventory of the oncological care and support care in these patients, in order to evaluate the need for a specific oncogeriatric intervention.

Quality of life and pain will be compared with a randomized residents control group, in each hospital.

Eligibility Criteria:
Inclusion Criteria:

* Affiliated to the social security system
* talking french language
* Cancer group: All residents with a history of cancer,
* Control group: residents without any history of cancer (same number of residents as in the cancer group), randomly selected in each nursing home, matched to age, sex, presence of dementia (mild or Moderate), and AGGIR dependancy scale

Exclusion Criteria:

* Severe dementia (MMS \<10/30) • Total disability to communicate
RESILIENT - An Online Multidimensional Treatment to Promote Resilience After a Disaster: Randomized Controlled Trial Protocol

Background. The wildfires on May 1, 2016 in Fort McMurray, Alberta (Canada), destroyed approximately 2,400 homes and buildings and led to massive displacement of approximately 88,000 people. Many individuals faced direct or potential threat to their life or health, or significant losses, and many months later, families were still living through ongoing adversity and uncertainty as they adapted to new or temporary homes, schools and workplaces. Alberta Health Services estimated in August 2016 that mental health staff in the city had received 20,000 referrals since May, compared to 1,200 referrals each year.

Objectives. The overarching aim of this project is to understand the needs of the Fort McMurray population in terms of mental health and to widely disseminate evidence-based tools to promote resilience. More specifically, we will assess the efficacy of an online self-help intervention targeting post-traumatic resilience on specific symptoms (post-traumatic stress disorder \[PTSD\], insomnia, depression).

Method. 1,510 phone surveys have been conducted in May-July 2017 to assess the prevalence of PTSD, insomnia and depression in the evacuees from the Fort McMurray wildfires (T0). After the survey, 697 participants expressed interest to participate in the longitudinal arm of the study, which will include four in-depth assessments with online questionnaires (T1 to T4) and a diagnostic interview (T1 only). A period of six months will separate all four times of assessment. Participants with post-traumatic stress symptoms (expected n = 150) will be randomised either to the treatment condition (n = 75) or to a waitlist control condition (n = 75) after completion of T2.

Data Analyses. Primary outcomes will be post-traumatic, depressive and insomnia symptom severity, measured with validated self-report questionnaires. Secondary outcomes will include cognitive, behavioural and social indicators, as well as general mental health and post-traumatic growth. Several probable moderators of treatment will be examined, including sociodemographic characteristics, level of exposure, and continuing stressors.

Foreseen Impacts. If found effective in reducing symptoms, the results of this study have the potential to impact positively the Fort McMurray community. Indeed, a direct and concrete deliverable of this research project will be to provide an extended (at least two years) and free access to the online intervention specifically tailored to this population's needs.


Eligibility Criteria:
Inclusion Criteria:

* Significant post-traumatic stress symptoms (PCL-5 ≥ 23) OR
* Some post-traumatic stress symptoms (PCL-5 ≥ 10) with at least mild depressive symptoms (PHQ-9 ≥ 5) and/or subclinical insomnia symptoms (ISI ≥ 8).
Dry Needling vs. Stretching for Non-Specific Low Back Pain

Chronic low back pain (CLBP) is one of the common health issues and a leading cause of reduced mobility. It is characterized by pain during functional activities and is often associated with hamstring tightness. CLBP affects individuals across all age groups. Various methods are used to address low back pain, including manual therapy. Manual therapy techniques include Maitland mobilizations, Kaltenborn mobilizations, Mulligan techniques, stretching, and others.

Several stretching techniques have been proposed, including static stretching, dynamic stretching, ballistic stretching, and proprioceptive neuromuscular facilitation (PNF). Among these, static and dynamic stretching are the most commonly used methods. Static stretching is considered one of the safest and easiest techniques, which can be performed passively or actively. Literature supports that stretching improves muscle flexibility, provides relaxation, reduces pain, and increases the range of motion (ROM).

Dry needling is another physical intervention technique that has been utilized for patients with musculoskeletal disorders. Current literature supports the use of dry needling for trigger points in hamstring muscles, which is a contributing factor to low back pain.

The objective of this study is to compare the effects of dry needling and stretching combined with sustained natural apophyseal glides (SNAGs) on pain, ROM, muscle length, and disability in patients with non-specific low back pain.

A randomized clinical trial will be conducted at Hijaz Hospital using convenience sampling to recruit participants. Patients will be allocated into two groups (Group A and Group B) through simple random sampling using sealed opaque envelopes. After conventional treatment, Group A will receive SNAGs and stretching, while Group B will receive SNAGs and dry needling.

Outcome measures will include the goniometer for ROM, the Modified Oswestry Disability Index (MODI) for disability, the Numeric Pain Rating Scale (NPRS) for pain, and the Finger-to-Floor Distance Test for hamstring flexibility. These measures will be assessed at baseline, at the 2nd week, and after 4 weeks. Data will be analyzed using SPSS software (version 21).

The normality of the data will be assessed using the Shapiro-Wilk test. Based on the results, parametric or non-parametric tests will be used for within-group and between-group comparisons. SNAGs and dry needling will be evaluated for their effectiveness in treating non-specific low back pain.


Eligibility Criteria:
Inclusion Criteria:

* minimum 3 months chronicity of low back pain
* with tight hamstrings and positive passive knee extension test (12)

Exclusion Criteria:

* Chronic systemic bony and soft tissue diseases
* Recent history of trauma
* Degenerative joint diseases
* Psychiatrist diseases