cyrilzakka/clinical-trials huggingface dataset:
Experiences With Automated Surgical Drainage in Cardiac Surgery

The purpose of this study is to evaluate the Thoraguard Surgical Drainage System in a real-world clinical environment. It is believed that this system will offer functional and clinical benefits over the current standard of care system for the removal of surgical fluids following cardiac surgery. Observations, experiences, and outcomes in a single hospital setting will be collected for the Thoraguard Surgical Drainage System.

The Thoraguard System is intended for use for drainage of blood, fluids, and gases following cardiac and thoracic surgery. The system consists of an electronic control module, drainage kit (fluid collection canister and drainage line), and chest tube kit with novel chest tube. The system continuously monitors chest tube and drainage line patency, automatically clears the chest tube and drainage line from build-up, and provides digital readings of fluid output trends. Additionally, the system has patient safety alarms to notify clinical staff of an unexpected event associated with post-operative drainage. These functions offer significant improvements over current standard of care. Reliable post-operative drainage, reduced workload, and decreased variability in chest tube maintenance procedures have the potential to increase patient safety, reduce complications, and improve patient experience.

Eligibility Criteria:
Inclusion Criteria:

* Adult (age ≥ 18)
* Patient undergoing non-emergent cardiac surgery
* Anticipated requirement for mediastinal chest tube drainage

Exclusion Criteria:

* Emergency surgery
* Re-do surgery
* Prior cardiac surgery
* Congenital cardiac disease or deformation
* Transplant surgery
* Ventricular Assist Device Surgery
* Suspected pulmonary air leak
* Atrial fibrillation
* In the opinion of the investigator the patient is unsuitable for the study for any other legitimate reason including incarceration, pre-existing medical or psychiatric condition, or interfering medications
* Known previous or concurrent enrollment in a clinical trial that, in the opinion of the investigator, might interfere with the objectives of this clinical trial
* Pregnancy
Characterization of Macroprolactinemia

The purpose of this study is to clarify the nature of macroprolactin which has recently been highlighted because of the high prevalence and a diagnostic pitfall of hyperprolactinemia. The results of this study are beneficial for the patients to whom unnecessary medications and unnecessary radiological examinations have been performed.

We used the remained serum samples taken for routine prolactin determination during the past several years. Since the blood was basically taken to examine the causes of hyperprolactinemia and only remained serum samples were used for this study, the Ethics Committee of Kobe City General Hospital judged that it was not required to obtain approval number.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of hyperprolactinemia
Public Perception and Attitude of Chinese Towards Biomedical Research and Biobanking in China

The purpose of this study is to collect date related to public knowledge and attitude towards biospecimen-based research and their willingness to participate in biobanking in China.


Eligibility Criteria:
Inclusion Criteria:

* individuals aged 18 years and above
* could understand the content of the questionnaire and express themselves
* voluntary to participate in this survey

Exclusion Criteria:

* history of mental illness or the deaf
* not able to express their views and opinions clearly
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.


Eligibility Criteria:
Inclusion Criteria

* Participants must have at least one measurable lesion per response evaluation criteria in solid tumors.
* Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1.
* Participants must have a life expectancy of at least 3 months at the time of the first dose.

Exclusion Criteria

* Participants must not have any mixed Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) histology.
* Participants must not have any untreated symptomatic central nervous system (CNS) metastases.
* Participants must not have a history of serious recurrent infections.
* Participants must not have a history of severe heart disease.
* Other protocol-defined Inclusion/Exclusion criteria apply.
JAB-BX102 Monotherapy and Combination With Pembrolizumab in Adult Patients With Advanced Solid Tumors

This study is to evaluate the safety and tolerability of JAB-BX102 monotherapy and combination therapy with pembrolizumab in adult participants with advanced solid tumors.

The primary objective of this study is to evaluate the safety and tolerability of JAB-BX102 monotherapy to determine the MTD(maximum tolerated dose) and RP2D(Recommended Phase 2 Dose) during Dose Escalation phase; then to evaluate preliminary antitumor activity when JAB-BX102 is administered in combination with pembrolizumab during Dose Expansion phase in patients with advanced solid tumors.

Eligibility Criteria:
Inclusion Criteria:

* Must be able to provide an archived tumor sample
* Must have histologically or cytologically confirmed metastatic or locally advanced solid tumor
* Must be refractory to or become intolerant of existing therapy(ies) known to provide clinical benefit for their condition, or patient has no access to SOC treatment.
* Must have at least 1 measurable lesion per RECIST v1.1
* Must have adequate organ functions

Exclusion Criteria:

* Has central nervous system(CNS) metastases or carcinomatous meningitis, except if CNS metastases treated and no evidence of radiographic progression or hemorrhage for at least 28 days
* Active infection requiring systemic treatment within 7 days
* Active hepatitis C virus(HBV), hepatitis C virus(HCV), or HIV
* Any severe and/or uncontrolled medical conditions
* Left ventricular ejection fraction(LVEF) ≤50% assessed by echocardiogram (ECHO) or multigated acquisition scan (MUGA)
* QTcF(Corrected QT interval - Fredericia formula) interval \>470 msec
* Experiencing unresolved CTCAE 5.0 Grade \>1 toxicities
Prediction of Quality of Life in Cardiovascular Disease

To develop an integrative predictive model of long-term quality of life in cardiovascular disease that emphasized adaptive processes and outcomes.

BACKGROUND:

Modern treatments for cardiovascular disease that enhance survival have increased the need to understand and improve corresponding aspects of quality of life. The increasing interest in prevention and health promotion in contemporary cardiovascular care emphasizes reducing risk factors that have major behavioral components, such as smoking, diet, and exercise. Personal and social resources and psychological coping strategies are associated with quality of life both directly and indirectly, through such positive health behaviors. Findings from this research provided an essential foundation for continued investigation focusing on longer-term changes in health status and quality of life in a planned ten-year follow-up with the present sample.

DESIGN NARRATIVE:

The study developed and tested an integrative prospective structural equation model of the interrelationships among social resources, coping strategies, positive health behaviors, and quality of life in cardiovascular disease over a four-year time-period. It also contrasted predictive findings relating to cardiac illness, stroke, and hypertension with predictive findings from matched-control groups of healthy individuals and individuals with very serious (cancer) and moderately serious (arthritis) noncardiovascular disease.

The research involved secondary data analysis with a large sample of individuals surveyed through the Center for Health Care Evaluation at the Stanford University Medical School. The sample included individuals between the ages of 55 and 65 who had used medical services in two large medical centers. Extensive psychosocial and physical health data were available from mail-out inventories at three points in time over a four- year period. Of eligible respondents contacts, 92 percent agreed to participate in the initial survey, and 89 percent (1884) of them provided complete data. Participation in one-year and four-year follow-ups approached 90 percent of surviving respondents from the previous survey. At the initial testing, 411 respondents (22 percent) reported diagnosed cardiac illness (excluding stroke and hypertension), 83 respondents (5 percent) reported diagnosed strokes, and 593 respondents (31 percent) reported diagnosed hypertension.

The data base at all three measurement times included extensive information on the quality of life, positive health behaviors, personal and social resources, and coping strategies. Computerized hospital medical records were available for one-third of the sample, and were used to evaluate the reliability of subjects' self-reports of medical conditions and health status. Group comparisons were made on two dimensions: illness type and post-illness time interval. Longitudinal analyses were used to examine causal influences on positive health behaviors and quality of life, and to develop and test an integrative predictive model.

Eligibility Criteria:
No eligibility criteria
Impact of Physical Therapy of Dysphagia on Preventing Pneumonia in Acute Stroke Patients

To investigate the impact of physical therapy intervention of dysphagia on preventing pneumonia in acute stroke patients

Seventy acute ischemic cerebrovascular stroke patients suffering from dysphagia were selected from the stroke unit in El-Kasr EL Ainy Hospital. Their ages ranged from 49 -65 years. Stroke dysphagia was diagnosed by a neurologist. Gugging swallowing screen and A2DS2 score was used to assess risk of developing pneumonia. Stroke associated pneumonia was diagnosed by: Recommended Diagnostic Criteria for Definite and Probable SAP in Patients Not Receiving Mechanical Ventilation Based on the CDC Criteria. The selected patients were randomly assigned into two equal groups control group (A) and study group (B). Control group (A) was treated by nasogastric tube and oral care. Study group (B) was treated as the control group in addition to a designed physical therapy program consisting of neuromuscular electrical stimulation in addition to exercises for oropharyngeal muscles. Assessment was done before treatment, at the middle and at the end of treatment for each patient. Treatment was conducted for five sessions per week for one month.

Eligibility Criteria:
Inclusion Criteria:

* All patients were diagnosed of stroke dysphagia by a neurologist.
* Severity of stroke ranged from mild to moderate according to NIHSS score (NIHSS less than or equal 16).
* Patients' age ranged from 49 to 65 years old.
* Patients had the ability to understand and follow instructions.
* Patients were able to sit in upright position.

Exclusion Criteria:

* History of previous stroke.
* History of any swallowing problem.
* History of any disease, head and neck surgery or tumor that causes swallowing dysfunction.
* Any lung disease or pneumonia on admission.
* Patients with cognitive deficits or disturbed conscious level.
* Patients on mechanical ventilator.
* Patients with sensory or global aphasia.
Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study

Due to the change of life style, the incidence of oral cavity mucous membrane disease increased.In this study，been done a large number of pre-clinical practice and some experimental studies， based on the application of metabolomics technology to ultra-high liquid-mass spectrometry metabolomics analyzer as the core means， The metabolism of pattern recognition and combination of modern analytical techniques to measure blood and urine of patients with OLP-specific clearance of endogenous metabolites，and after the intervention of moss drink endogenous metabolites in the body as a whole group of. At the same time， the use of flow cytometry,，ELISA， immunohistochemistry and other modern technology, research OLP patients using clean moss drink before and after treatment of local lesions and peripheral blood CD4 +，CD8 + lymphocytes，Th1 cytokines (IFN-γ， TNF-α)， Th2 cytokines (IL-4，10) the dynamic changes. From metabolomics， cellular immunology， inflammation mechanism perspective of local OLP lesions， peripheral blood and changes in endogenous metabolites in the process,，in-depth study of traditional Chinese medicine to drink clean moss multi-component multi-target treatment of this disease mechanism， is widely used in traditional Chinese medicine treatment of OLP provide a theoretical basis for the promotion of Chinese medicine Qingxian Yin in the oral mucosal disease in the application， effectively solve clinical practice problems.


Eligibility Criteria:
Inclusion Criteria:

* All patients with OLP .
* TCM syndrome of OLP patients included is dryness pathogen type.
* In the lesions of oral mucosa there are phanerous pearly white keratinization stripes, or patches, or phanerous erosion with the mucous membrane hyperemia.
* OLP patients may accompany oral coarse discomfort or pain, red tongue, yellow dry or dry fur, dry mouth, bitter taste.

Exclusion Criteria:

* Patients with other established oral mucosal disease;
* Patients accompanied by serious systemic diseases, eg damaged liver or kidney functions; Or other allergic diseases, eg rheumatic disease or cancer.
* Patients using the antibiotic in the last one month or immunologic agents in the last three months.
* Lichenoid reaction caused by drugs or the filling with silver and amalgam.
* Patients with smoking or alcoholism in the last three months.
Survey Of Mobilisation and Breathing Exercises After Thoracic and Abdominal Surgery

Background

Thoracic or abdominal surgeries are followed by a shorter or longer period of immobilization and after major surgery there is a higher risk of developing cardiorespiratory complications. To prevent these complications, the patient is encouraged to change position and exercise in bed, get out of bed as early and as much as possible after the operation and to breathe with or without aids. There is no general definition of early mobilization and may start within a few hours to a few days after surgery. There is currently a lack of knowledge nationally and internationally about when the mobilization starts and what it contains.

Many patients also receive breathing training in connection with the surgery. There is currently no consensus on which method is preferable for which groups of patients. There are similarities and differences in practice in the world regarding postoperative breathing training. There are studies that have mapped practice after primarily thoracic surgery but also abdominal surgery. However, there are no studies that have mapped when the prescribed breathing training starts after different types of operations.

The purpose of the study is to map when mobilization and breathing training starts after abdominal and thoracic surgery and what is then performed

Method The study will be carried out as a quality follow-up with mapping of practice. Patients ≥ 18 years of age who are undergoing a planned or acute open, keyhole or robot-assisted surgery, who are extubated and who breathe spontaneously will be included. Exclusion criteria are completed plastic, trauma, orthopedic or transplant surgery.

The material will be recruited from Swedish university hospitals and county hospitals for 20 days of surgery (Monday through Thursday) for five consecutive weeks.

Clinical benefit The study will mean that clinical practice is presented which, with regard to mobilization, is the first study ever that will present when this takes place and what is done and, with regard to breathing training, the first that shows when this training is initiated.


Eligibility Criteria:
Inclusion Criteria:

* ≥ 18 years of age
* undergoing a planned or acute open, laparoscopic or robot-assisted surgeon in the thorax or abdomen
* who are extubated within 24 h of surgery
* breathe spontaneously within 24 h of surgery

Exclusion Criteria:

* reconstructive-, trauma-, transplantation- or orthopedic surgery.
Predictive Factors of Endoscopic Mucosal Healing in Quiescent Ulcerative Colitis

The purpose of this study is to determine whether fecal calprotectin, fecal immunochemical test, and Rome III criteria for irritable bowel syndrome (IBS) can predict mucosal healing in patients with quiescent ulcerative colitis (UC).


Eligibility Criteria:
Inclusion Criteria:

* Patients with ulcerative colitis who have no change of medication for at least 6 months
* Patients with ulcerative colitis who are in remission (Mayo score \<3)
* Patients with ulcerative colitis who will undergo colonoscopy for surveillance or mucosal healing check-up

Exclusion Criteria:

* Patients who refuse to participate
* Patients who have a history of colectomy
* Patients who have instinal stricture or perforation
A Phase I Study of a Single Dose of Radio-labeled BMS-275183 in Patients With Advanced Cancer

The first purpose of this study is to determine how the body absorbs, metabolizes, and eliminates a single dose of BMS-275183 (labeled with radioactive carbon). Secondly, to measure the levels of BMS-275183 in your blood, study the safety of the drug, and to see what effects it has on your cancer.


Eligibility Criteria:
Inclusion Criteria:

* Non-hematological malignancy that has progressed on standard therapy
* No more that 3 prior chemotherapies given for advanced cancer
* Adequate renal, hepatic and hematologic function

Exclusion Criteria:

* Uncontrolled or significant pulmonary or cardiovascular disease
* Active Brain metastases
* Inability to swallow capsules
* Serious uncontrolled medical disorder or active infection
Burnout Syndrome Among Medical Residents

Whether and to what extent burnout risk is actually higher in surgical specialties than in non-surgical specialties is still unknown. Little is also known about what factors are associated with burnout between surgical residents and non-surgical residents. In this context, the present study has a three-fold aim: 1) to measure the prevalence of burnout among a sample of Italian medical residents; 2) to contrast the prevalence of burnout and psychological distress in surgical residents and non-surgical residents, and 3) to identify the work-related factors associated with burnout between surgical residents and non-surgical residents.

Surgical training is considered to be very stressful among residents and graduating medical students choose less often surgery for their career. To elaborate burnout prevention programs, the assessment of the prevalence of burnout during the early career stage of the surgeons and associated risk factors, becomes central.

Residents from the University of Bologna were asked to participate in an anonymous online survey. The residents completed a set of questions regarding their training schedule and three standardized questionnaires: 1) the Maslach Burnout Inventory, assessing the three dimensions of burnout: emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA); 2) the Zung Self-Rating Depression scale; 3) the Psychosomatic Problems scale. High scores in either the EE or DP subscale categories predicted professional burnout.

Eligibility Criteria:
Inclusion Criteria:

* residents attending the University of Bologna

Exclusion Criteria:

* none
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

The proposed study is a single-site, randomized, controlled clinical trial (RCT) comparing ketamine-assisted psychotherapy (KAP) to a standard evidence-based regimen of ketamine administered in a medical model without psychotherapy (KET). Eligible study participants will be adults with major depressive disorder (MDD). Adults with MDD will be randomized to KAP or KET in a 1:1 allocation. Each treatment group will receive KAP or KET over a period of four weeks. Measurement of depression severity, wellness, neurocognitive functioning and other parameters will occur at baseline prior to treatment, immediately following the end of the acute treatment period, and over an 8-week (two month) treatment follow-up period.


Eligibility Criteria:
Inclusion Criteria

* Written informed consent (and assent when applicable) obtained from subject and ability for subject to comply with the requirements of the study.
* Age 18-90 years
* Participant in good physical health
* Participants may be on medications for depression as long as they remain on a stable dose.
* A score of at least 20 on the 10 item Montgomery-Asberg Depression Scale at screening, corresponding to at least moderate current depression severity.
* Meets criteria for major depressive disorder (MDD) in current major depressive episode (MDE) according to DSM-5
* Women of child-bearing potential must have a negative pregnancy test at screening and prior to ketamine infusion

Exclusion Criteria

* Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
* Any unstable medical illnesses including hepatic, renal, gastroenterological, respiratory, cardiovascular (including ischemic heart disease and uncontrolled hypertension); endocrinologic, neurologic, immunologic, or hematologic disease
* Clinically significant abnormalities of laboratories, physical examination, or ECG
* Substance drug or alcohol use disorder in the prior 12 months
* History of hypersensitivity to ketamine or esketamine
* Lifetime history of schizophrenia, schizoaffective disorder, bipolar I or II disorder
* Presence of psychotic symptoms in the current MDE, or lifetime psychotic disorder
* Recreational ketamine or phencyclidine use in the last year
* Previous non-response to clinical or research ketamine or esketamine administration
* Concurrent treatment with ECT, TMS, or VNS in the current MDE
* BMI \> 35
* Significant suicidal ideation as determined by a C-SSRS score \>2 in past 30 days
* History of suicide attempt or self harm in the prior 2 years
* SBP \> 165 or DBP \> 95 on infusion day
* MoCA score \< 23
The Assessment of Microcirculation in Brachial Plexus Block Using Perfusion Index and Capillary Filling Time

The aim of the present study is to assess the effects of brachial plexus block on microcirculation using pefusion index and capillary filling time.

Microcirculation is very crucial to evaluate the organ function those working properly in human body. The aim of the present study is to assess the effects of brachial plexus block on microcirculation using pefusion index and capillary filling time. A total of 50 patients whose planned to underwent surgery are performed brachial plexus block using ultrasound, and pefusion index, heart rate, blood pressure, capillary filling time are measured at 0, 10th and 20th minutes interval and at postoperative 24th hours. All measures will be recorded.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists score of I and III
* ages between 18 and 70
* upper extremity surgery

Exclusion Criteria:

* not to participate in the study
* reject to perform the intervention
* infection in injection cite
* allergy to local anesthetics
* peripherical vasculary diseases
* psychiatric diseases
* coagulation anomalies