Safety, Tolerability, and Immunogenicity of VAL-339851 in Healthy Adult Subjects

This clinical study will assess the safety, tolerability and immunogenicity of VAL-339851 in healthy subjects.


Eligibility Criteria:
Inclusion Criteria:

* Agrees to comply with the study procedures and provides written informed consent
* 18 to 49 years of age
* Body mass index between 18 and 35 kg/m2
* Negative urine pregnancy test at the Screening visit and the day of each vaccination for females of childbearing potential.
* Female subjects must either be of non-childbearing potential or use acceptable methods of contraception from at least 3 weeks prior to enrollment and through the end of study visit
* In good health based on medical history, physical examination, vital sign measurements and laboratory safety tests performed prior to initial study vaccination
* Has access to a consistent and reliable means of telephone contact and agrees to stay in contact with the study site for the duration of the study

Exclusion Criteria:

* Any ongoing, symptomatic acute or chronic illness requiring medical or surgical care
* Administration of another investigational product within 60 days, or 5 half-lives, whichever is longer
* Participation in an investigational study involving lipid nanoparticles
* A history of hypersensitivity or serious reactions to previous influenza vaccinations
* History of Guillain-Barré Syndrome within 6 weeks following a previous influenza vaccine
* History of narcolepsy
* Administration of any licensed (inactivated or live) vaccines within 4 weeks before enrollment or plans to receive any vaccine within 12 weeks of the last study drug administration; receipt of any other avian H7N9 influenza vaccine at any time prior to or during the study is exclusionary
* Any known or suspected immunosuppressive condition, acquired or congenital, as determined by history and/or physical examination.
* Any chronic administration of immunosuppressant or other immune-modifying drugs within 6 months prior to administration of study vaccine
* Administration of immunoglobulins and/or any blood products within the 3 months preceding the administration of the study vaccine or during the study.
* Any acute disease at the time of enrollment
* Any significant disorder of coagulation requiring ongoing or intermittent treatment
* Active neoplastic disease or a history of any hematologic malignancy
* History of alcohol abuse or drug addiction within 1 year before the planned day of dose administration
* A positive test result for drugs of abuse or alcohol at screening or before the first dose administration
* Persons employed in a capacity that involves handling poultry or wild birds.
* The subject has any abnormality or permanent body art (eg, tattoo) that, in the opinion of the investigator, would obstruct the ability to observe local reactions at the injection site
* Any condition, that in the opinion of the Investigator would pose a health risk to the subject if enrolled or could interfere with evaluation of the vaccine or interpretation of the study results
* A positive test result for hepatitis B surface antigen, hepatitis C virus antibody, or human immunodeficiency virus types 1 or 2 antibodies at screening
* Donation of blood or blood products \> 450 mL within 30 days of dosing