cyrilzakka/clinical-trials huggingface dataset:
Depression and ART Adherence in HIV+ Latinos

The current HIV treatment adherence project was designed to adapt culturally and then pilot test an empirically supported cognitive-behavioral therapy program for adherence and symptoms of depression (CBT-AD)with HIV+ Latinos living on the U.S.-Mexico Border.

Additionally, the investigators will assess the feasibility and efficacy of a novel medication monitoring and reminder system (MedSignals®) in the form of an electronic pillbox with monitoring and reminding functions that is available in a Spanish-language version. Our hypotheses are grounded in a conceptual model proposing that the CBT-AD intervention will improve problem-solving ability and decrease depressive symptomatology, which will directly improve biomedical outcomes of HIV-1 RNA viral load and CD4 as well as indirectly improve biomedical outcomes through increased motivation, improved memory, and better medication adherence. Evaluating and implementing generalizable and sustainable mental health and adherence interventions such as the ones proposed are urgently needed in the region to improve HIV treatment outcomes and thwart the development and transmission of drug resistant virus.

Eligibility Criteria:
Inclusion Criteria:

* HIV+ participants (a) currently receiving HIV care at La Fe CARE Center (study site);
* 18 years of age or older;
* Latino (i.e., self-identified as being of Mexican heritage);
* English- or Spanish-speaking
* capable of giving informed consent;
* currently on a prescribed antiretroviral regimen;
* suboptimally adherent (i.e., demonstrated either by a VL load taken in the last 12 months that is above the undetectable threshold of 50 mL copies or self-reporting a missed dose in the last two weeks);
* exhibiting some depressive symptomatology (i.e., scoring on the Beck Depression Inventory-1A 10 or above), and (i) male or female (including transgender Female-to-Male and Male-To-Female.

Exclusion Criteria:

* actively psychotic or so cognitively impaired that they cannot participate,
* so physically ill as to be unable to come to the clinic to participate in the intervention, OR
* Report The use of crack, cocaine, heroin, OR methamphetamines to any extent in the past 40 days.
* Those who are planning on being away from the area for any extended period during the study (as in the case of seasonal workers) or whom
* have household members already enrolled in the study will also be excluded. We did choose to restrict study eligibility to individuals of Mexican descent.
Intermittent Hypoxia Paired with High Intensity Training in Brain Injury

The central hypotheses are that HIT combined with AIH results in: 1) greater locomotor gains as compared to HIT alone; 2) improvements in gait quality and motor coordination during walking, and 3) changes in measures of community participation and integration.

The central hypotheses are that HIT combined with AIH results in: 1) greater locomotor gains as compared to HIT alone; 2) improvements in gait quality and motor coordination during walking, and 3) changes in measures of community participation and integration. To test these hypotheses, the proposed crossover, assessor-blinded, randomized clinical trial (RCT) is designed to test the effects of safety, feasibility, and preliminary efficacy of HIT+AIH. In this phase I-II trial, patients \>6 months post-BI with mobility deficits will be allocated to 5 weeks (15 sessions) of HIT+AIH or HIT alone. Blinded assessments will be performed prior to and following training paradigms to address 3 specific aims.

Eligibility Criteria:
Inclusion Criteria:

* \> 6 months post brain injury
* 18-85 years old
* ability to walk without physical assistance
* Self selected walking speed of 0.01-1.0 m/s

Exclusion Criteria:

* \<18 years old
* \>85 years old
* self selected walking speed of \> 1.0 m/s
* \< 3 months from botulinum toxin injection above the knee brace
* Currently receiving physical therapy
Skin Elasticity Measurements of the Face and Surgical Scars Stratified by Age and Skin Type

The primary objective of Part A is to compare the change in elasticity measurements at baseline and at 3 months between subjects who have had a resurfacing or tightening procedure and those who have not. The secondary objective for Part A is to develop baseline elasticity scores for ages 18-35, 36-50, and 51-65 and for Fitzpatrick skin types I-II, III-IV, and V-VI. The primary objective of Part B is to compare the age of the scar and surrounding tissue with the elasticity measurements.


Eligibility Criteria:
Inclusion Criteria:

Part A:

* Subject is 18-65 years of age
* Subject scheduled to have resurfacing or tightening procedure done as Standard of Care (Arm 1, 25 subjects).
* The subject has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator

Part B:

* Subject is 18 and over
* Subject has a linear surgical scar that is \> 2cm.
* The subject has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator

Exclusion Criteria:

Part A, Group 1:

-Subject is planning on having a cosmetic procedure done to their face during the 3 months they are participating in the study (Arm 2, 25 subjects).

Parts A and B:

* Under 18 years of age
* Pregnancy or Lactation
* Subjects who are unable to understand the protocol or to give informed consent
* Subjects with mental illness
A Comparison of Two Different Wrist Immobilization Methods

The aim of this study is to examine the effect of the splint and rigid taping on the muscle activation of the upper trapezius muscle during computer typing tasks in office workers.

The study will be conducted on 10 healthy office workers. The study subjects will be asked to type on a computer for 5 minutes (1) without splint or taping, (2) with a splint and (3) with rigid taping which limits the wrist flexion at the dominant side. The upper trapezius muscle activation will be recorded by surface EMG during the task. The mean values will be normalized according to Maximum Voluntary Isometric Contraction (MVIC) and %MVIC values.


Eligibility Criteria:
Inclusion Criteria:

* Being an office worker between 20-35 years of age
* Using a computer for at least 4 hours a day
* Working full time for at least 1 year without any upper extremity pathology

Exclusion Criteria:

* Having a body mass index of 30 kg / m2 or more on the day of evaluation
* Using muscle relaxants 72 hours before the evaluation
* Exercising within the last 48 hours
Comparison of Laparoscopic Herniotomy and Open Herniotomy in Children

All patients of age 6 month to 12 years with inguinal hernia were included in study.

Data was collected on detailed proforma regarding age, sex, side ,operative time, cosmesis , and postoperative complications

BACKGROUND: The best method of inguinal hernia repair in children continues to be a topic of debate. Although recent data shows that LPEC is superior and safe but no such data exists in our country. Operative time and recurrence are main concerns. Hence, present study is carried out to compare outcome of LPEC versus OHR in children.

OBJECTIVE: To compare the outcome of laparoscopic percutaneous extra-peritoneal closure and open repair for inguinal hernia in children METHODOLOGY: It was a randomized control trial conducted on 66 patients (33 in each group) presented to our hospital with features of Inguinal Hernia. Patients were admitted after confirmation of diagnosis by ultrasound and complete blood count (CBC) was sent. Pre operatively patients were divided in two groups randomly (Open Hernia Repair group, LPEC group) by closed envelope method. Consent was taken from parents regarding inclusion in the study. All demographic data and results were noted down in a proforma. The collected data was entered and analyzed in computer software SPSS (Statistical Package for Social Sciences) version 26.0.

Eligibility Criteria:
Inclusion Criteria:

All patients of age 6 months to 12 years of either gender having unilateral or bilateral inguinal hernia diagnosed on history, clinical examination and investigations.

Exclusion Criteria:

1. Patients with recurrent inguinal hernia, hydrocele, hernia with undescended testes and Sliding hernia diagnosed on history, clinical examination and investigations.
2. Patients with complicated hernia (e.g. incarcerated ovary), irreducible or obstructed inguinal hernia diagnosed on history, clinical examination and investigations.
3. Patients who cannot tolerate pneumoperitoneum or general anaesthesia.
4. Patients with congenital heart disease, other co-morbid conditions.

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Prognostic Measures in Ambulatory Care Settings

The primary objective of this prospective study is to develop a new method of classifying the prognosis of ambulatory patients according to their risk of long term mortality, institutionalization, morbidity (including the deterioration of pre-existing conditions or development of new problems) and functional deterioration.

Specifically, from a random sample of 2000 patients taken from a cohort of established patients followed for at least three years in a general medicine practice, the objectives are:

1. to identify the demographic, clinical, and functional status variable that predict the risk of death, morbid events (e.g., the development of new complications or deterioration of existing conditions), or the deterioration in functional status using a half of the cohort chosen at random;
2. to combine these findings into a prognostic scale that can be employed in routine clinical practice; and
3. to validate the performance of this scale in the second half of the cohort.

There are no interventions in this study. Patients already under medical care by Cornell physicians will be enrolled. The only requirements for patients are to complete the questionnaires on an annual basis.

Eligibility Criteria:
Inclusion Criteria:

1. Patients who are currently under the care of Physicians at Cornell Internal Medicine Associates.

Exclusion Criteria:

1. Patients who do not wish to participate in the study.
2. Patients who are not able to provide informed written consent.
A Phase 2 Dose Ranging, Evaluator-Blinded Study to Evaluate the Safety of Topical IDP-118

Subjects with a clinical diagnosis of plaque psoriasis with 10% to 20% of body surface area affected will be enrolled in the study.

Approximately 60 subjects with a clinical diagnosis of moderate or severe psoriasis (defined as at least of 10 % - 20% treatable Body Surface Area (BSA) and an Investigator's Global Evaluation (IGE) of 3 or 4 at baseline (moderate or severe) will be enrolled in the study.

Eligibility Criteria:
Inclusion Criteria:

* Male or female of any race, 18 to 65 (inclusive) years of age.
* Freely given verbal and written informed consent obtained from the subject.
* Clinical diagnosis of psoriasis at the Screening and Baseline visits with
* At least 10% - 20% of total treatable BSA involvement, and
* an Investigator's Global Evaluation score of 3 or 4 ( moderate or severe) on a scale of 0 to 5
* Good general health as determined by the Investigator based on the subject's medical history and physical examination, with Screening hematology, serum chemistry, and urinalysis laboratory values within normal range limits.

Exclusion Criteria:

* Presence of psoriasis that was previously treated with prescription medication prior to the Screening visit and is non-responsive to corticosteroid treatment, as determined by the Investigator.
* Presence of any concurrent skin condition that could interfere with the evaluation of the study drug, as determined by the Investigator.
* History of adrenal disease
* Female who is pregnant, nursing an infant, or planning a pregnancy during the study period.
Climate Impact Label Design and Fast-Food Meal Selection

The primary objective of this study is to test the relative effects of climate-impact menu label designs on the healthfulness of consumers' fast-food meal choices. Participants will complete a hypothetical online meal ordering task using a survey which emulates the online menu of a burger restaurant chain. Participants will be randomized for exposure to menus featuring one of five labeling conditions. Secondary objectives include examining total greenhouse gas emissions per meal order and, through a post-order survey, perception of labels between the conditions.

This online randomized trial will test the relative effects of climate impact menu label designs on the healthfulness of consumers' fast-food meal choices and perceptions of menu items. The survey research firm CloudResearch will recruit a sample of 6,250 adults aged 18 years and older who speak English and reside in the United States.

Participants will complete a between-subjects online experiment in which the participants will be randomized to view a fast-food online ordering menu with one of five labeling schemes applied: (1) a QR code on all items (control); (2) a high climate impact warning label on high impact items; (3) traffic light labels on all items by level of impact; (4) climate grade labels on all items by level of impact; and (5) numeric carbon footprint labels on all items. All fast-food menus will include main items, sides, desserts, and drinks. Labels will only appear alongside main menu items and will be assigned using thresholds for greenhouse gas emissions set a priori in kilograms of carbon dioxide (CO2) equivalent per kilogram of food. Participants will be instructed to select up to 4 menu items for a hypothetical meal order. After completing the meal ordering task, participants will be prompted to answer questions about the perception of the labeling condition which the participants were randomized to view, perception of the relative effectiveness of all labels in this experiment, and personal values, dietary patterns, and other demographic information.

The primary outcome will be the healthfulness of meal orders selected from the online menu, indicated by a modified Nutrient Profile Index meal score for all food items ordered. Secondary outcomes will be total greenhouse gas emissions per meal ordered, total calories ordered, whether a sugar-sweetened beverage was ordered, and perceived message effectiveness of the climate-impact labels.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* Member of the CloudResearch panel
* Residing in the United States

Exclusion Criteria:

* Under 18 years of age
* Not residing in the United States
* Completed the survey implausibly quick based on the distribution of the time to complete the survey among all participants
* Failed the built-in Qualtrics survey fraud detection measures
Self-management and Quality of Life in Individuals With Type 2 Diabetes Mellitus

The study was conducted in order to study the effect of the training given according to social-cognitive learning theory (SCLT) upon diabetes self-management and quality of life among type 2 diabetes mellitus individuals.

The study was done as a randomized-controlled experimental study at Internal Diseases Polyclinics of Afyonkarahisar Public Hospital between November 2021 and August 2022. The study was completed with 60 patients -experimental group (30 patients) and control group (30 patients)- who met inclusion criteria. The data were gathered using Information Request Form and Metabolic Variables Form, Diabetes Self-Management Scale (DSMS) for Type 2 Diabetic Patients, Multidimensional Scale of Perceived Social Support (MSPSS), Type 2 Diabetes Mellitus Self-Management Questionnaire (SMQ), WHOQOL-BREF (WHO- Quality of Life Scale- Short form). A theoretical and practical training based on SCLT was provided to the experimental group for the first five weeks -one module for each week- through power point presentations and afterwards, SMS reminders were sent every fifteen days for seven weeks and at the end of the twelfth week the training was completed. The control group received a standard training from diabetes nurse. The data were assessed using statistical methods.

Eligibility Criteria:
Inclusion Criteria:

* 18 years and over
* Being diagnosed with Type 2 diabetes mellitus,
* Being on insulin therapy,
* Being open to verbal communication,
* Being literate
* Not to have an obstacle to continue the implementation phase of the research (for example, pregnancy plan, changing province, etc.)
* Not having hearing-vision problems and diabetes-related serious neuropathy (amputation, etc.),
* Patients who agreed to participate in the study.

Exclusion Criteria:The patient has a perception disorder and psychiatric disorder that prevents communication,

* Being pregnant,
* Individuals with serious complications such as retinopathy and neuropathy at the level of blindness were excluded from the study.

Research Termination Criteria

* Not performing the specified applications properly during the study,
* Unreachable in follow-ups,
* Those who want to quit working,
* Serious complications related to comorbid diseases and diabetes that occur during the working process,
* The study was terminated with patients who were moved out of the province during the study.
Effect of Group-Task-Oriented Training on GMFM and ADL in Children With DS

Down syndrome, a genetic condition resulting from an additional copy of chromosome 21, manifests with distinct facial features and intellectual challenges. Individuals with Down syndrome often face delays in motor skills, speech, and language development, alongside potential health issues. Down syndrome commonly encounter difficulties in both gross and fine motor functions due to factors like low muscle tone. Nonetheless, targeted interventions, including physical, significantly enhance motor skills. Daily living activities for individuals with Down syndrome cover personal care and household tasks, with structured routines and consistent support fostering independence. Group Task-Oriented Training, focusing on skill improvement and social interaction through collaborative activities, offers a meaningful approach to enhancing the overall quality of life for individuals with Down syndrome.

Group A receive Group-Task-Oriented Training. Group B receive routine therapy. Both the groups receive intervention for 40 minutes per session 4 times a week for six weeks.This study will be a randomized controlled trial and will be completed over a 10-month period in Lahore. Data will be collected from PSRD Hospital and Rising Sun Institute for Special Children. The estimated sample size is 44 participants, will be divided into two groups using non-probability convenient sampling. Inclusion criteria for Down syndrome children aged 4-8 include willingness to engage in Group-Task-Oriented Training sessions and stable health conditions. Exclusion criteria involve recent surgeries or severe medical conditions hindering participation. Data collection tools comprise the Jebsen hand function test, Gross Motor Function Measure, and Pediatric Evaluation of Disability Inventory.Participants are randomly assigned to an Experimental Group undergoing group task-oriented training and a Control Group receiving routine physical therapy. The training sessions for both groups are detailed, focusing on motor skills, fine motor function, gait training, and activities of daily living.

Eligibility Criteria:
Inclusion Criteria:

* Down syndrome children age ranged between 4-8 years (20).
* Both male and female genders are included (21).
* Children and their families willing to engage in Group-Task-Oriented Training sessions (20).
* Participants in stable health conditions suitable for engaging in the prescribed training program (20).

Exclusion Criteria:

* Any recent surgical procedure (21).
* Children with severe medical conditions or comorbidities that may interfere with participation in the Group-Task-Oriented Training (21).
* Children with severe physical limitations that could hinder active participation in the training sessions (21)
Articaine Plus Dexmedetomidine in Supraclavicular Block

Articaine has emerged as a local anesthetic (LA) that produces sensory and motor blockade shorter than bupivacaine and lower in neurotoxicity than lidocaine.

Studies have shown that adding dexmedetomidine to LA produces prolongation of sensory and motor bock duration.

Early regain of motor power with adequate analgesia is needed in ambulatory surgery, for early start of physiotherapy. This study was designed to test efficacy of adding dexmedetomidine to articaine on the duration of sensory and motor block.

Articaine is an amide LA produced in the 1960s and first used in clinical trials in 1974. Although it is an amide that is similar to prilocaine in chemical structure, it contains a thiophene ring rather than a benzene ring. Articaine is a rapid and short acting LA, which has low neurotoxicity and appears to diffuse through tissues more readily than other commonly used LA agents. It is metabolized by nonspecific plasma esterases both in blood and tissues, leading to its rapid clearance.

α2-adrenergic receptor agonists have been the focus of interest for their sedative, analgesic, perioperative sympatholytic, and cardiovascular stabilizing effects along with providing reduction in anesthetic requirements. Dexmedetomidine may act on supraspinal (locus coeruleus) or spinal level or peripheral α2-adrenoreceptor to reduce nociceptive transmission, leading to analgesia.

Previous trials focused on adding dexmedetomidine to either levobupivacaine and bupivacaine, found augmentation of both sensory and motor block along with prolonged duration of effective analgesia. However, there remains limited knowledge of the analgesic efficacy and clinical utility of adding dexmedetomidine to articaine during peripheral nerve block in humans.

Eligibility Criteria:
Inclusion Criteria:

* aged 18-60 years planned for upper limb surgery below the midhumerus with an expected time of less than 90 min usually under tourniquet.

Exclusion Criteria:

* allergies to local anesthetic,
* those with ASA III and IV,
* patients who refuse to participate,
* uncooperative patients,
* patients who have infection at the site of injection,
* patients who have bleeding disorder, and patients on anticoagulant drugs.