cyrilzakka/clinical-trials huggingface dataset:
Diagnostic Strategies in Patients Suspected of Irritable Bowel Syndrome

The purpose of this study is to determine whether a clinical diagnosis of irritable bowel syndrome based on patient reported symptoms and a few blood tests is safe, and to determine whether a clinical diagnosis is as good for the patient and as economical for the society as a diagnosis based on exclusion of a number of organic diseases by performing a number of blood tests, fecal analyzes and a scopic examination of bowel.

The purpose of the second part of the study is to determine which intestinal parasites the patients have in their bowel and whether these parasites are the cause of the disease.


Eligibility Criteria:
Inclusion Criteria:

* age 18-50 years
* consultant in general practice for gastrointestinal symptoms, where the GP suspects irritable bowel syndrome
* full fill the ROME III criteria
* signed informed consent

Exclusion Criteria:

* alarm signals
* pregnancy
* comorbid diseases, that interfere with primary endpoint
* medicine and alcohol abuse
* patient do not speak or understand danish
* investigations for irritable bowel syndrome with in the last 3 years

from november 2008: patients aged above 40 with a duration shorter than one year
Interest of Soft Point Anesthesia in Association With Locoregional Anesthesia in Arthroscopic Shoulder Surgery

This is a prospective, single-center, observational study. The inclusion period is set at 12 months.


Eligibility Criteria:
Inclusion Criteria:

* Patient aged 18 years or older
* Patient informed about the study and who has not opposed the use of their personal medical data
* Patient scheduled for arthroscopic shoulder surgery

Exclusion Criteria:

* Allergy to local anesthetics or epinephrine
* Contraindications to Interscalene Block (e.g., respiratory disease, pneumothorax, pneumonectomy, phrenic or recurrent laryngeal nerve paralysis)
* Coagulation disorder
* Patients unable to understand the study information and objectives: dementia, psychosis, consciousness disorders, non-French-speaking patients
* Patients under legal protection measures (guardianship, curatorship) or deprived of liberty by judicial or administrative decision
Non Invasive Mechanical Ventilation VERSUS Oxygen MASK

Conventional mechanical ventilation is a core feature of intensive care. Weaning and removal of endotracheal tube are crucial processes, which often account for a considerable part of Conventional mechanical ventilation total time. Unsuccessful extubation has been noted to be associated with an increase of both morbidity and mortality in adult and pediatric patients

The documented rate of failed extubations ranges from 4.1 to 14% in pediatric intensive care units.Therefore, strategies preventing the need for reintubation are needed.

Non invasive ventilation has been proposed as useful therapy to wean patients after unsuccessful weaning trials and to avoid reintubation in adults, though controversy exists at this concern.

This technique is increasingly being used in pediatric patients over the last years. The objective of the present study was to determine post extubation Non invasive ventilation characteristics and to identify risk factors of post extubation Non invasive ventilation failure in children

Eligibility Criteria:
Inclusion Criteria:

all the patients with successful weaning from invasive mechanical ventilation

Exclusion Criteria:

1. Maxillofacial trauma
2. Gastrointestinal obstruction
3. Severe lung secretion
4. Irreversible organ failure
Delayed Loading Following Repair of a Ruptured Achilles Tendon

The purpose of the study is to investigate if delayed loading following surgical treated Achilles tendon rupture influence the clinical outcome and muscle and tendon structure after one year.

The investigators hypothesize that delaying the gradual introduction of loading in the initial 26 weeks may reduce the heel-rise deficit (primary outcome) and thus improve the clinical outcome one year after surgery (primary endpoint).


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with a traumatic, complete mid-substance Achilles tendon
* No contraindications for MRI
* Presented within 14 days from injury
* Adult (18 to 60 years)
* Understand Danish
* Manage transport to/from the hospital on their own

Exclusion Criteria:

* Other injuries affecting their lower limb functions
* Prior Achilles tendon Rupture
* Smoking
* Systemic diseases influencing tendon healing
* Anticoagulation treatment
* Inability to follow rehabilitation or complete follow-ups
* Immunosuppressive treatment including systematic corticosteroid treatment
Iontophoresis in Psoriasis

Iontophoresis potentially may be a good alternative to improved delivery of corticosteroids. Study Investigators propose to use iontophoresis to increase dexamethasone delivery into thick psoriasis plaques. The primary purpose of this study is to assess whether dexamethasone sodium phosphate iontophoresis is an effective local therapy for psoriasis. The objective of the study is to determine the efficacy of dexamethasone sodium phosphate iontophoresis for psoriasis.

Subjects who meet the selection criteria will be offered an opportunity to take part in this study. This will be a prospective controlled study. After written informed consent, 20 subjects with symmetric thick plaque psoriasis lesions on the extremities and/or trunk will be enrolled and randomized to receive one activated iontophoresis patch containing dexamethasone sodium phosphate and another inactive control iontophoresis patch containing dexamethasone sodium phosphate on each limb containing a thick psoriatic plaque. Members of the research team will apply the patches. After application of the patch, subjects will be asked to return to the clinic in 1 week and 2 weeks. Efficacy will be measured at the 1-week and 2-week follow-up visit using a scale for erythema, scale, and thickness called the static Physician Global Assessment (sPGA) and subject satisfaction to treatment will be measured at the 2 week-follow-up using the PsoSat Questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* Greater than or equal to 18 years of age.
* Subjects with diagnosed plaque-type psoriasis that is stable.
* Similar psoriasis plaques found on each limb and/or different sides of the trunk.
* Willingness to attend all scheduled visits and complete the study.
* Ability to understand and sign an informed consent form.

Exclusion Criteria:

* Known allergy to dexamethasone or any component of the formulation and iontophoresis components.
* Change in the use of systemic therapy in psoriasis within 4 weeks prior to applying iontophoresis patches (to allow time for washout).
* Use of topical therapy (including coal tar, salicylic acid, topical corticosteroids, vitamin D, vitamin A, urea) or recent phototherapy for psoriasis within 2 weeks prior to applying iontophoresis patches (to allow time for washout).
* Pregnancy or breast feeding women.
* Any other condition, in the judgement of the investigator, would put the subject at unacceptable risk to participate.
Determination of the Predictors of Nocturnal Desaturation in Postpartum Women

The primary aim of the study is to evaluate the effect of the method of delivery (vaginal delivery vs. cesarean section) on oxygen saturation in the first postpartum night. The investigators hypothesize that nocturnal desaturation occurs more frequently in cesarean section compared with vaginal delivery, expressed as either the duration of SpO2 below 90% or the Oxygen Desaturation Index (ODI). The ODI is defined as number of oxygen desaturations by at least 3 % per hour. Furthermore, the investigators expect a higher pulse rate and a lower mean and minimum SpO2 in the cesarean section group compared with the vaginal delivery group.

The secondary aim of the study is to investigate how the upper body position during sleep (45 degree elevated vs. non-elevated) affects the oxygen saturation during the first postpartum night.

The investigators hypothesize that an upper body elevation to 45 degrees decreases the incidence of desaturation events, expressed as either the duration of SpO2 below 90% or the ODI , compared with a non-elevated body position within each delivery group (vaginal delivery or cesarean section).

The third aim of the study is to identify independent predictors of nocturnal desaturation in postpartum women. To that end, the investigators will administer questionnaires and collect demographic and clinical data according to various obstructive sleep apnea screening scores, including the P-SAP, STOP-Bang, and Epworth Sleepiness Scale. The investigators will also ask the patient to rate the pain during the study night on a verbal numerical rating scale.

Sleep-disordered breathing is common in pregnancy, persisting into the early postpartum period. Postpartum airway obstruction is a main cause of anesthesia-related maternal death in North America. Upper airway edema following labor and delivery may impair pharyngeal anatomy, which can lead to increased vulnerability of the airway collapse during sleep.

This study evaluates whether the kind of delivery (vaginal birth versus cesarean section) has an effect on nocturnal desaturation in the first night after delivery. Furthermore, the investigators examine if the upper body position during sleep has an effect on the occurrence of oxygen desaturation.

In addition, the investigators evaluate if preexisting conditions, as indicated by a high P-SAP or STOP-Bang-score increase the likelihood of nocturnal desaturation.

Eligibility Criteria:
Inclusion Criteria:

* Postpartum mothers within 24 hours of delivery
* Age over 18 years.
* Admitted to the Massachusetts General Hospital OB service for the delivery.
* Interventions will be randomly assigned to the patients enrolled in this study

Exclusion Criteria:

* 1 Age under 18 years
Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele

Varicose veins in the scrotum (varicocele) are responsible for \>20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3 of cases. The goal of this study is to identify markers that predict the outcome of variocele correction. This would offer considerable health cost savings.

Based on preliminary findings, we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium, a toxic metal, and expression of genes required for normal sperm function. The semen and biopsies will be obtained during clinically dictated procedures. Cadmium and gene expression will be compared with response to varicocele repair (i.e., increased sperm production; pregnancy).


Eligibility Criteria:
* Healthy male with varicocele (grades 2 \[palpable\] or 3 \[visible, palpable\]) and no other diagnosed cause for infertility
* Non-smoker
* Actively desiring children but never having initiated a pregnancy
* Female partner having no unresolved fertility issues
Comprehensive Therapy to Relieving the Risk of Recurrence and Metastasis for Colorectal Cancer

Comprehensive therapy of traditional Chinese medicine (CTTCM) could relieve risk of recurrence and metastasis for stage II \& III colorectal cancer, the investigators take this clinical trial with retrospective-prospective cohort study based on previous studies by international multi-center way.

If the study shows a positive result, a pragmatic randomized controlled study with prospective, multi-centre and large-sample design will be given continuously. The aim is to establish recommended programs suggested by CTTCM strategies under conventional Western medicine therapy (CWMT) for stage II \& III colorectal cancer.

CTTCM: taking TCM decoction based on syndrome differentiation daily and each dosage is decocted two times for intervention one year with a Chinese patent medicine at least.

CWMT: with or without chemotherapy/or radiotherapy after the radical operation (R0) (according to the latest NCCN clinical guideline).

Eligibility Criteria:
Inclusion Criteria:

* Patient who is diagnosed colorectal cancer by patho\& cytologic diagnosis since accepting radical operation within half a year.
* Stage II or III colorectal cancer.
* 18-75 yr.
* Being able to participate and sign the informed consent.

Exclusion Criteria:

* Pregnant woman, Psychotic.
* Patient who put together with other cancer.
* Existed serious complaint and functional disturbance (impairment) with non-tumorous in arch-organ.
* Reactiveness cerebrovascular disease (CVD) .
* Uncontrolled infection and metabolic disease.
* One item of tumor marks is progressed, and it still is progressed when patient recheck.
* Tumor that it is neo-occurred in each organ or pelvic cavity or abdominal cavity without definite patho-quality.
The Potential Association of Long Non-coding RNA (NEAT1 and MALAT1) in the Process of Epithelial-mesenchymal Transition in Periodontitis

Periodontitis is a polymicrobial, inflammatory condition affecting tooth-supporting tissues. It is characterized by a progressive loss of epithelial attachment and resorption of alveolar bone, which can lead to tooth loss. Epithelial-mesenchymal transition (EMT) has been proposed as a reversible process that shifts the cell phenotype from epithelial to mesenchymal-like and may be involved in the process of periodontal inflammation either completely or partially. Long non-coding RNAs (lncRNAs) are a large class of regulatory transcripts longer than 200 nucleotides lacking evident protein-coding potential. Studies have shown that lncRNA dysregulation plays key roles in human diseases, including cancer, by modulating the epithelial-mesenchymal transition (EMT). The involvement of lncRNAs markers in the pathogenesis of periodontal disease induced EMT has not been studied thoroughly and have created a gap in the knowledge.


Eligibility Criteria:
Inclusion Criteria:

* Patients with no history of systemic disease e.g., diabetes.
* Both males and females will be included in the study.
* Control group: patients fit the case definition of gingival health2, and confirmed by Histopathological inflammatory cell infiltration analysis.
* Periodontitis group: patients fit the case definition of periodontal disease referred for periodontal flap surgery (modified Widman's flap).
* Patients radiographically confirmed with infrabony pocket eligible for periodontal flap surgery.

Exclusion Criteria:

* Patients not willing to participate or consent.
* Patient taking medications that affect or modify immunity (e.g., corticosteroid), for the last 3 months.
* Patient taking NSAIDs for the last 3 months.
* Active smoker.
Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease

A multi-center, double-blind, placebo-controlled out-patient, safety, tolerability, and pilot efficacy study of intramuscular AN-1792 in patients with mild to moderate Alzheimer's disease.

The study will enroll approximately 375 patients with mild to moderate Alzheimer's disease at investigational sites in the United States and Europe. Patients will receive either AN-1792 or placebo, and they will be evaluated using standard clinical assessments of cognition and memory as well as experimental surrogate markers of Alzheimer's disease pathology. The goal of the study is to evaluate the clinical impact of eliciting an immune response (formation of antibodies) to the A-beta peptide in patients with Alzheimer's disease.

Eligibility Criteria:
Mild to moderate Alzheimer's disease. Ability to cooperate with MRI scanning and neuropsychological testing. Live at home or in the community and a caregiver capable of accompanying the patient on all clinic visits and visiting the patient at least 5 times per week.
Interprofessional Preoperative Geriatric Assessment for Older Arthroplasty Patients With Multimorbidity

The objective of this randomized control trial is to investigate effects and cost effectiveness of interprofessional preoperative assessment among older knee or hip arthroplasty patients. The main hypothesis is that preoperative assessment and optimization have a positive impact on the patents' quality of life and expenditure of social and health care services.

Knee and hip arthrosis are common conditions among older adults. Progression of arthrosis often leads to worsening of symptoms and decreased mobility, daily functioning and quality of life. Total joint arthroplasty improves pain in end-stage arthrosis but accustomed postoperative care and rehabilitation alone may not guarantee optimal regain of functioning for frail and vulnerable older arthroplasty patients. Preoperative optimization of older patients with multimorbidity and functional limitations may improve benefits of the arthroplasty even at lower costs. Patients randomized into intervention arm of the present study receive preoperative assessment with treatment and prehabilitation plan. The focuses of the intervention are patient's chronic conditions, nutritional status, medication and physical activity. The intervention is delivered by multiprofessional team (geriatrician, registered nurse, physiotherapist and pharmacist).

Older adults undergoing surgery are a rapidly growing but vulnerable patient group. Knowledge on effects of preoperative evaluation and optimization is sparse, especially on the effects of multi-domain interventions.

Eligibility Criteria:
Inclusion Criteria:

* Place of residence: Kuopio or Vesanto municipality
* Age ≥ 65 years
* Clinical decision for knee or hip arthroplasty, elective operation with more than one month waiting time, primary arthroplasty of the index joint.
* Multimorbidity: the patient has at least two chronic diseases with potential to affect functioning, diseases are defined according to the Function Comorbidity Index (FCI)

Additional inclusion criteria, at least two of the following:

* 5 or more medicines taken regularly (polypharmacy)
* continuous walking distance less than 500 m
* needs help in dressing and/or washing oneself
* needs help when visiting or taking care of businesses outside home
* body mass index ≤ 23 or ≥ 34

Exclusion Criteria:

- does not meet the above inclusion criteria
Chronic Pain After Lung Transplantation, an Incidence Study

This is an investigation on the frequency of chronic pain amongst recipients after lung transplantation. Factors relating to the development of chronic pain are investigated.


Eligibility Criteria:
Inclusion Criteria:

* Able to understand and give consent
* Can read
* Residing in Denmark

Exclusion Criteria:

* Unable to understand the written information in Danish
* Abuse (Medicine, Drugs, Alcohol)
* Severe psychiatric Illness
* Conflicting neurological disease
Reducing Behavioral Risk Factors of NCDs: Protocol for a School-based Health Education Program in Bangladesh

This is a before-after designed intervention study conducted in two randomly selected secondary schools- one was selected randomly as intervention school and the another as control school. A baseline survey was conducted among the students of both schools by a pre-tested questionnaire to attain their current status of knowledge, attitude and practices related to NCDs. Afterward, students were enrolled in the intervention group who met the eligibility criteria from the intervention school. The intervention was given through a health promotion session to a group of students, not more than 25 at a time, by trained facilitators. A post-intervention end line survey was conducted among all the participants from both schools using the same questionnaire three months after the baseline survey. An intervention has been developed based on some principals of two psychosocial theory- Motivational Interview and Social Cognitive Theory. Emphasis was given on motivating the adolescents towards a healthy lifestyle, supporting self-efficacy to be changed, guiding self-regulatory ways along with facilitating desired changing process by empowering them with choices about the preventive measures of NCDs. This intervention is expected to increase awareness by equipping the adolescents with specific knowledge and skills and thus, facilitate an eventual change in their practiced risk behaviors.


Eligibility Criteria:
Inclusion Criteria:

• Practicing at least two risk behaviors from three- unhealthy diet, physical inactivity and smoking

Exclusion Criteria:

• Physically disabled or having limited movement
Trends of Acute Intoxication in Poison Control Centre

the study aim to investigate the trend of poisoning and its causative agents among different egyption people ages between 2015 and 2019

This study aim to report different types of intoxication, the significant ages that intend to accidently ingest poisons or commit suicide, and the most commonly used chemicals in toxication, showing different rautes of administration between the years 2015 and 2019

Eligibility Criteria:
Inclusion Criteria:

- all medical records for patients admitted to PCC-ASUH emergency departmentwith the diagnosis of acute intoxication from 2015 t0 2019

Exclusion Criteria:

- any cases of acute intoxication before 2015 or after the end of 2019 cases of chronic intoxications were excluded
Study of Amrubicin With or Without Herceptin in Patients With Metastatic Breast Cancer

The purpose of the study is to evaluate the incidence of cardiac toxicity of amrubicin when administered to patients with metastatic breast cancer.


Eligibility Criteria:
Inclusion Criteria:

* Histological or cytological diagnosis of breast cancer.
* Metastatic or recurrent disease, either HER2+ (FISH+ or 3+ IHC) or HER2-.
* Maximal dose of prior adjuvant anthracycline: 300 mg/meters squared doxorubicin or equivalent. Relapse greater than one year after trastuzumab adjuvantly; two years following adjuvant anthracycline therapy (without trastuzumab).
* One prior chemotherapy for metastatic breast cancer allowed (may include trastuzumab for HER2+ patients), but no prior Doxil, adriamycin or epirubicin for metastatic breast cancer.
* At least 18 years of age.
* ECOG Performance Status of 0, 1, or 2.
* Adequate organ function including the following:

  * Adequate bone marrow reserve.
  * Cardiac: Left ventricular ejection fraction (LVEF) greater than or equal to 55% by MUGA.
* Negative serum pregnancy test at the time of enrollment for women of child-bearing potential.
* Ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and to return for the required assessments.

Exclusion Criteria:

* Pregnant or nursing women.
* Concurrent anticancer therapy.
* Participation in any investigational drug study within 28 days prior to study entry.
* Concurrent severe or uncontrolled medical disease (i.e., active systemic infection, diabetes, uncontrolled hypertension, coronary artery disease, congestive heart failure, severe arrhythmia) that, in the opinion of the Investigator, would compromise the safety of the patient or compromise the ability of the patient to complete the study.
* Symptomatic central nervous system metastases. Patients with asymptomatic brain metastases are allowed. The patient must be stable after radiotherapy for greater than or equal to 2 weeks and off corticosteroids for greater than or equal to 1 week.
* History of interstitial lung disease or pulmonary fibrosis.