cyrilzakka/clinical-trials huggingface dataset:
Comparative Evaluation of Shade Matching Using a Digital Spectrophotometer in Monochromatic Versus Polychromatic Layering Techniques for Restoring Fractured Incisal Angles of Maxillary Incisors - Invivo Study

The color and appearance of a tooth is complex phenomenon which is related to many factors such as color stability, The Blending Effect, color Induction, color assimilation effect of resin composite materials which are all fall under the Term Chameleon Effect Which Enables Resin composite material to obtain a shade that bears a resemblance to the color of the surrounding tooth structure. The usage of different opacities and shades to match the tooth structure is very time consuming for both patient and clinician. However, any clinical effectiveness of any dental restorative procedures such as composite replacement is dependent on their physical, chemical and mechanical features which are highly proportional with oral environment and resin material properties.

Resin Composite Material allow light scattering between Enamel and Dentin Which aid in Internal diffusion So That Resin Composite Material blend with the surroundings. The color alteration Also is directly proportional with light absorption to make it undetectable when blended with tooth structure A Significant disadvantage of resin composite restorations is highly susceptibility to staining and discoloration by the time and aging process in the oral environment. Color instability is one of the main reasons for replacing restorations, particularly in anterior teeth. There are several factors that affect the color stability of resin composite including intrinsic factors, namely the chemical make-up of the materials. Moreover, other extrinsic factors including smoking and poor oral hygiene, as well as the absorption of dyes from consuming foods and beverages in the oral cavity influence the color stability of resin composite restoration.

The color of any observed restoration is dedicated by light scattering between resin composite material and other substrates such as Tooth structure beneath restoration and other hard dental tissues. Natural teeth and resin composite material should share Three basic parameters Chroma , Hue and Value . Other Parameters effect on observation such as opacity, translucency, glossy surface should be put in consideration During resin based composite manufacturing.

This investigation sought to determine the effectiveness of three distinct approaches to shade matching when restoring class iv in dental maxillary incisors using universal Universal shade dental composite technique, traditional polychromatic layering dental composite technique, and contemporary monochromatic single shade dental composite technique.

Eligibility Criteria:
Inclusion Criteria:

* fractured incisal angles in vital maxillary permanent incisors
* aged 16 to 35
* exhibits good oral hygiene

Exclusion Criteria:

* individuals with nonvital or endodontically treated teeth
* active periodontal disease
* significant medical complications
* malocclusion
* parafunctional habits
A Study to Investigate How Safe and Effective Solifenacin Solution is in Treating Children/Adolescents With Symptoms of Overactive Bladder (OAB) Who Completed Study 905-CL-076

This was a 40-week study to investigate how safe and effective solifenacin solution was in treating children or adolescents with symptoms of overactive bladder (OAB), who completed study 905-CL-076 (NCT01565707).

There was a titration period of up to 12 weeks during which the participants would be up or down-titrated based on a combination of efficacy and safety parameters followed by a fixed dose period during which no dose adjustments were allowed. Participants completed a 7-day patient diary prior to every visit (start of 905-CL-076 to end of 905-CL-077, 14 visits). The first visit of this study (905-CL-077) was combined with the last visit of the 4-month study 905-CL-076. At each visit, the participant was required to undertake a number of assessments or examinations to determine whether it is safe for him/her to take part or to continue to take part in the study.

Eligibility Criteria:
Inclusion Criteria:

* Subject has met the inclusion criteria of study 905-CL-076 and completed study 905-CL-076

Exclusion Criteria:

* Subject has failed the exclusion criteria of study 905-CL-076
Effects of Exercise Intervention in Patients With Spondylolisthesis Related LBP

The first purpose of this study is to define parameters of the trunk neuromuscular functions that are pathologically altered in patients with low back pain due to spondylolytic spondylolisthesis. The second and also the main purpose of the study is to examine the effects of exercise intervention on patients with low back pain due to spondylolytic spondylolisthesis. Our overall hypothesis is that specific exercise intervention will improve neuromuscular functions of the trunk in patients with low back pain due to spondylolytic spondylolisthesis.

Low back pain is known to affect a considerable portion (\> 75%) of the society, causing enormous financial burden for the healthcare systems.

Exercise interventions incorporated into low back pain patients rehabilitation protocols are known as successful treatment strategies, but ore often focused on strength training and not on functional stabilization. Spondylolytic spondylolisthesis is one of the most known types of spine instabilities. To date, no studies examined the effects of exercise intervention on patients with low back pain due to spondylolytic spondylolisthesis. Research will be carried out as a cross-sectional study, where patients with spondylolytic spondylolisthesis will be randomly arranged in one controlled and two experimental groups. For the forth group healthy asymptomatic participants will be recruited.

Exercise intervention will last 12 weeks with a frequency of three times a week and duration of 60 minutes per training unit. Exercise intervention will include congregated set of trunk stabilisation exercises, starting with simple isometric tasks. Dynamic and more complex movements will be added progressively to achieve whole body tasks involving fast and sudden movements.

Neuromuscular functions of the trunk will be measured before and after the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Low back pain presence for at least three months.
* Age between 20 and 60 years.
* Isthmic Spondylolisthesis (1st and 2nd level according to Meyerding) at L5/S1 and L4/L5.
* Body mass index below 30.
* without neurological pathological conditions.

Exclusion Criteria:

* Intermittent claudication pain.
* History of operational treatment of the lumbar spine.
* Traumatic, oncological, infectional pathology of the spine
* Degenerative stenosis of the lumbar spinal canal.
Duration of Dual Anti-Platelet Therapy (DUAL-ACS)

Despite substantial evidence supporting the use of dual anti-platelet therapy in patients with acute coronary syndrome, there remains major uncertainty regarding the optimal duration of therapy. Recent evidence suggests that shorter durations of dual anti-platelet therapy are superior because the avoidance of atherothrombotic events is counterbalanced by the greater risks of excess major bleeding with apparent increases in all-cause mortality with longer durations. We here propose an international randomised controlled trial of 18,318 patients with type 1 myocardial infarction allocated to differing durations of dual anti-platelet therapy. We will use electronic health record linkage to track duration of therapy and clinical outcomes in a real-world, real-time, efficient and highly cost-effective trial. This has the potential to define treatment duration, settle a major outstanding international controversy, and influence modern cardiology practice across the world.


Eligibility Criteria:
Inclusion Criteria:

* Aged ≥18 years
* Clinical diagnosis of Type 1 myocardial infarction within 12 weeks
* In the opinion of the attending clinician requires dual anti-platelet therapy with aspirin and a P2Y12 receptor antagonist
* Resident in the country of recruitment with their unique health identifier
* The attending clinician has equipoise regarding the duration of therapy
* Provision of informed consent

Exclusion Criteria:

* Clear indication for specific duration of dual anti-platelet therapy
* Type 2 myocardial infarction
* Contraindication to aspirin or P2Y12 receptor antagonist
* Non-resident in the country of recruitment
* Previous recruitment into the trial
* Inability or unwilling to give informed consent
Study of Time-restricted Eating (TRE) to Clinical Pregnancy Rate in PCOS Women With Glucose Metabolism Disorder Via IVF/ICSI

Investigate the effect and mechanism of time-restricted eating (TRE) on the clinical pregnancy rate in women with PCOS and glucose metabolism disorder via IVF/ ICSI.

In this multicenter randomized controlled study, investigators plan to recruit 254 patients, aged 20-38, with PCOS and glucose metabolism disorder. PCOS diagnostic criteria based on Rotterdam 2003 criteria, glucose metabolism disorder are diagnosed by 1998 WHO diagnostic criteria, with HbA1c≤7%. Participants selected are overweight or obese (24Kg/m2 ≤ BMI ≤40Kg/m2), and are planned to start the 1st/ 2nd cycle of IVF/ ICSI.

Investigators divide these patients randomly into 2 groups (each group with 127 patients): metformin only group (control group) and TRE with metformin group. Every participant receives the specific treatment according to the group for at least 6 weeks. During the intervention period, follow-ups, blood chemistry tests and examinations are recorded every 2 weeks. After the intervention period, IVF/ ICSI is carried out. GnRH-agonist- or/and hCG-triggered is used for ovarian stimulation. Ovum retrieval will be carried out 34-36h after ovarian stimulation. Blood hCG is tested after 12-14 days after embryonic transfer. For patients with positive hCG, clinical pregnancy is confirmed by observing gestational sac via transvaginal ultrasound after 4-5 weeks.

Investigators compare the terminal pregnancy-related result and metabolic changes between 2 groups to determine the effect and the possible mechanisms of TRE on IVF/ ICSI clinical pregnancy rate of PCOS with glucose metabolism disorder patients.

Eligibility Criteria:
Inclusion Criteria:

1. Diagnosed with PCOS based on Rotterdam 2003 (all 3 criteria should be fulfilled);
2. Diagnosed with glucose metabolism disorder (IGT, IFG, IGT with IFG, T2DM) and HbA1c less than or equal to 7%;
3. Age 20-38;
4. Overweight or obese (24Kg/m2 ≤ BMI ≤40Kg/m2);
5. Indication for IVF/ ICSI (repeated ovarian stimulation failure/ Fallopian tube blockage/ male factor) and ready for the 1st/ 2nd cycle of IVF;
6. Cooperative to follow-ups and capable of reporting severe adverse event (SAE);
7. Completed informed consent.

Exclusion Criteria:

1. Unilateral ovary resection;
2. Abnormal uterus cavity (congenital, chronic endometrium inflammation, polyps, adhesion, fibroids, etc);
3. Chromosomal abnormality (either maternal or paternal);
4. Recurrent abortion or recurrent failure of embryo transfer;
5. Metformin allergy/ intolerance;
6. Other serious or uncontrolled diseases (e.g. kidney insufficiency, infection, controlled hypertension, heart disease, etc);
7. Preimplantation genetic testing;
8. Other condition that may impact the results
Effect of Gastric Bypass Surgery on Diabetes Status and Microvascular Complications in Obese Type 2 Diabetic Patients

This study evaluates the long-term benefits of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus, focussing on the prevalence and predictors of T2DM improvement and remission after RYGB, and subsequently relapse of type 2 diabetes mellitus after RYGB. Moreover, the study evaluates the possible effect of RYGB on diabetic microvascular complications such as nephropathy and retinopathy. Finally, the study provides insight into the factors influencing glucose-insulin homeostasis after RYGB, including altered microbiota diversity and bile acid levels.

One hundred Danish type 2 diabetes mellitus (T2DM) patients who underwent Roux-en-Y gastric bypass surgery (RYGB) between 2006-2011 will be evaluated clinically together with 50 T2DM patients, matched on gender, age, presurgical body mass index, and diabetes duration.

The clinical follow-up consists of a physiological check-up, a thorough paraclinical work-up, and a whole body dual-energy x-ray absorptiometry (body composition and bone mineral density) a peripheral quantitative compute tomography (HR-pQCT), stool samples (microbiota), ophthalmological examination including retina photo, and a questionaire.

More over, a liquid meal test with sampling of total bile acids, fibroblast growth factor 19 and 21 (FGF 19 and FGF 21), plasma glucose, and insulin will be performed on a smaller part of the patients.

Eligibility Criteria:
Inclusion Criteria:

* Capable
* type 2 diabetes mellitus
* speaks and understands Danish
* presents written concent
* cases must be Roux-en-Y operated between 2006-2011.

Exclusion Criteria:

* Converted Roux-en-Y
* chronic inflammatory bowel disease
* ischemic heart disease
* liver disease
* cholecystectomy.

Controls can not be bariatric operated.
Observational Study in Preterm Infants With Intracranial Hemorrhage

Intracranial Hemorrhage (ICH) is an important morbidity affecting premature infants and can have considerable effects on neurodevelopmental outcome.

The investigators showed that preterm infants with severe ICH have decreased cerebral oxygenation several weeks after the hemorrhage. The mechanisms involved in this state of decreased cerebral oxygenation in preterm infants and the effects on cerebral function are unknown.

This longitudinal observation study will evaluate physiologic parameters to determine trends in cerebral oxygenation and function in preterm infants with ICH in comparison to infants without ICH.


Eligibility Criteria:
Inclusion Criteria:

* Preterm infants born between 23 and 28 weeks of gestation
* Diagnosed with ICH grades II or higher during the first week after birth
* Matched control infants without ICH.

Exclusion Criteria:

* Major congenital malformations
* Birth asphyxia
* Not expected to survive
Home-based in Chronic Obstructive Pulmonary Disease

Pulmonary rehabilitation consists of a multidisciplinary program of care for patients with chronic respiratory disease, which currently encompasses numerous features and physical training methods aimed at maintaining stability clinic for people with Chronic Obstructive Pulmonary Disease (COPD), especially in patients who, even with optimized clinical treatment, continue their decline and symptomatic physical functions and 8 so that these social. goals are achieved the patient with COPD should integrate into a program of RP assiduous and with accompanying several times per week, for several months, which for a number of factors is not always possible. For this reason, it is the research of methodology of RP that hold their effectiveness, but with greater flexibility and viability to people with COPD. On this basis, this study aims to investigate the effectiveness of a program of RP semi-domiciliar in which the patient suffering from COPD can receive guidance and training in person, to develop it partially in own domicile.

The protocol of the experimental procedure will begin with the explanation of the purpose, risks and benefits of the study volunteers to patients with COPD. Subsequently, based on an evaluation form, will collect data on the past history and current disease and performed a general physical examination. Then the patients will respond to two questionnaires. The first will research the Medical Council (MRC) 13, which is a dyspnea scale to categorize in terms of disability, patients with COPD. The second questionnaire will be the Airway Questionnaire 20 (AQ20) 14 specific for obstructive pulmonary disease, which is validated for the local language and highly reliable for the evaluation of patients with COPD, containing 20 questions related to respiratory health to evaluate the quality of life. Subsequently, the same day, the patients carry out the following tests: spirometry, respiratory muscle strength, respiratory muscle endurance, assessment of training load of the upper and shuttle test and bioimpedance

Eligibility Criteria:
Inclusion Criteria:

* will be included patients of both sexes,
* over 40 years and diagnosis of COPD according to criteria of ATS, GOLD and II Brazilian Consensus of COPD.
* must be medically stable,
* without having presented the framework of exacerbation of disease over the past 30 days and,
* must have agreed to participate in this study which, after being presented and explained to patients, this accepted should be confirmed by Subscription Term of free and informed consent, pursuant to resolution 96 of 1996 of MS.

Exclusion Criteria:

* will be excluded from the study patients with serious comorbidity,
* orthopedic diseases such as heart defects in upper and lower limbs,
* sequelae of motor neurological disorders or impaired that may interfere with the ability to carry out physical exercise,
* uncontrolled hypertension,
* lung diseases and
* those who do not grant support to participation in this study.
High-flow Nasal Oxygenation for Open Mouth

This study aims to evaluate the effect of high-flow nasal oxygenation on safe apnea time for children undergoing general anesthesia, with their mouth open.

Oxygenation via high-flow nasal cannula is gaining popularity in various clinical settings. It is known to increase apnea time for apneic patients including children. However, high-flow nasal cannula is known to be ineffective when the patient's mouth is kept open.

When trying to intubate the patient during induction of anesthesia, the patient should be apneic with administration of neuromuscular blocking agent, and the mouth should be open for introduction of laryngoscope.

We designed a prospective randomized controlled study to evaluate the effect of high-flow nasal oxygenation in the aforementioned setting for trying to intubate the patient.

Eligibility Criteria:
Inclusion Criteria:

* Children younger than 11 years old scheduled to undergo surgery under general anesthesia, with American Society of Anesthesiologists Physical Status 1 or 2.

Exclusion Criteria:

* Refusal to enrollment from one or more of legal guardians of the patient
* Children who are planned to use supraglottic airway device
* Children with upper respiratory tract infection or pulmonary interstitial disease
* Preterm babies under 40 weeks of postconceptual age
* Children who are expected to have difficult airway for bag-mask ventilation
Robotic Bronchoscopy With Cone CT and Indocyanine Green to Aid Removal of Lung Lesions in Patients With Stage I Non-small Cell Lung Cancer or Lung Metastases, REPLACING Study

This phase II trial studies the use of Ion robotic bronchoscope with a mobile computed tomography (CT) scanner to biopsy tumors and inject a fluorescent dye called indocyanine green to mark the tumor during surgery in patients with stage I non-small cell lung cancer or cancer that has spread to the lung (lung metastases). Sometimes small tumors or those that are not on the surface of the lung can be challenging to remove without making larger incisions. Injecting the dye, may help doctors see the tumor more easily, which may allow for smaller incisions and by being able to see the tumor, doctors may be better able to decide where to make the incisions in order to get all of the tumor out.

PRIMARY OBJECTIVE:

I. To evaluate the feasibility of using the Ion Endoluminal Platform (IEP; Intuitive, Sunnyvale, California \[CA\]) with the Cios Spin - a mobile cone-beam C - (Siemens Medical Solutions, Malvern, Pennsylvania \[PA\], United States \[US\]) in the operating room setting.

OUTLINE:

During standard of care surgical resection, patients undergo robotic bronchoscopy and CT. Patients also receive indocyanine green via injection.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-80 years
* Medically operable
* Undergoing pulmonary resection for either stage I non-small cell lung cancer (NSCLC) (undergoing segmentectomy) or metastatic disease to the lung
* Lesions \< 2cm in longest diameter
* Lesions are located at least 1cm from the pleura

Exclusion Criteria:

* Pregnant
* Serum creatinine \> 2.0
* Central lesions
* Iodide allergy
Mulligan Rotational Movement Versus Medial Gapping Technique in Patients With Knee Osteoarthritis

Knee osteoarthritis is a progressive degenerative and non-inflammatory joint disorder. Due to the extensive use and stress placed on knee joint, it is a common site for painful disorders such as knee osteoarthritis. It is seen that medial side of knee is most commonly affected because of weight bearing on medial side. Symptomatically, the knee joint is most commonly affected in osteoarthritis because it requires support, high mobility, and insufficient internal stability. Osteoarthritis of the knee joint affects three parts of the knee joint (medial, lateral, and patellar-femoral joints) and develops slowly, usually over 10-15 years, interfering with daily activities Slow and gentle movements like Tai Chi, Isometric, iso-kinetic and isotonic exercises are considered helpful in increasing joint range of motion and physical function. Stretching and aquatic therapy can also decrease pain and enhance joint flexibility. The aim of this study is to compare the effects of Mulligan rotational movement vs Medial gapping technique on pain, range of motion and disability in knee osteoarthritis.

This study will be a randomized control trial and will be conducted in Riphah clinics and LGH. The study will be completed within the time duration of six months. Non-probability convenient sampling technique will be used to collect the data. Those who will meet the inclusion criteria will be recruited in the group. The sample size of patients with knee osteoarthritis will be taken in this study to find the effects of Mulligan Rotational movements vs. Medial gap technique, aged between 20-40 years, will be allocated to an intervention or control group. The scales used for recording findings will be goniometer, visual analogue scale and modified disability index. Subjects will randomly divide into control group called group A Taking Mulligan therapy and Interventional group called group B taking Median Gapping Technique. 12 sessions over 6 weeks were performed on both groups. Data analysis will be done by SPSS version 25.


Eligibility Criteria:
Inclusion Criteria:

* Post-traumatic stiffness of knee
* Restricted range of knee flexion
* Patients with restricted ROM and with Grade 3 or more than three power of knee muscle

Exclusion Criteria:

* Patients with hyper mobile and unstable joints
* Joint infection and loosening,
* Soft tissue injuries around knee joints and
* Other complications of post-fracture