cyrilzakka/clinical-trials huggingface dataset:
Functional MRC With Eovist for Acute Cholecystitis

Functional magnetic resonance cholangiography (fMRC) with gadoxetate disodium (Eovist) is an accurate method of diagnosing acute cholecystitis.

Primary Objective:

To determine the accuracy of fMRC in evaluating patients with suspected cholecystitis.

Secondary Objective:

To compare the results of fMRC with conventional hepatobiliary scintigraphy.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* Symptoms of right upper quadrant pain with ambiguous US (and/or CT) findings
* Standard of care nuclear medicine hepatobiliary scan to rule out acute cholecystitis -

Exclusion Criteria:

* Scheduled for emergent surgery, or is otherwise determined by the Investigator that the subject is clinically unsuitable for the study
* Glomerular filtration rate (GFR) below 60 mL/min/1.73m2
* Total bilirubin above 3.0 mg/dL
* Inability to provide informed consent (altered or diminished mental status)
* Allergic to morphine
* Known or suspected hypersensitivity to gadolinium-based agents
* The standard MRI contraindications apply, including but not limited to: having a pacemaker or other implanted electronic device, metal foreign bodies within the eye, aneurysm clips, heart valve prosthesis, vascular stents, coils, intrauterine devices (IUDs), penile implants, inferior vena cava (IVC) filters, gunshot wounds with retained bullet fragments.
* Pregnant or breast-feeding -
Bilateral Prefrontal Modulation in Crack-cocaine Addiction

In this study, eligible crack-cocaine addicted inpatients recruited from specialized clinics for substance abuse disorder treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive the repetitive (10 sessions, every other day) bilateral dorsolateral Prefrontal Cortex (dlPFC: cathodal left / anodal right) tDCS (2 milliamperes, 3x7 cm2, for 20 min) or placebo (sham-tDCS). Craving to the use of crack-cocaine was examined before (baseline), during and after the end of the tDCS treatment.

Based in our previous data, our hypothesis was that repetitive bilateral tDCS over dlPFC would favorably change clinical, cognitive and brain function in crack-cocaine addiction and these would be long-lasting effects.

Before (baseline) and after tDCS or sham-tDCS treatment, subjects were examined:

(1) clinically, regarding craving (obsessive compulsive scale) and relapses to the drug use.

They were followed-up for clinical examination at least 60 days after treatment.

Eligibility Criteria:
Inclusion Criteria:

* patients between the age of 18 and 60 years;
* met criteria for crack-cocaine dependence according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), as determined by clinical evaluation;
* in stable clinical condition with no need for inpatient care;
* able to read, write, and speak Portuguese; and
* no severe withdrawal signs or symptoms at baseline.

Exclusion Criteria:

* a condition of intoxication or withdrawal due to a substance other than crack-cocaine;
* unstable mental or medical disorder or substance abuse or addiction other than crack-cocaine dependence, except nicotine and/or caffeine;
* a diagnosis of epilepsy, convulsions;
* a previous history of drug hypersensitivity or adverse reactions to diazepam or other benzodiazepines and haloperidol;
* any contraindication for electrical brain stimulation procedures such as electronic implants or metal implants;
* suspected pregnancy for female participants;
Effects of Sprint Interval Training on Field Hockey Players.

Field hockey is a team sport that is played using sticks and balls. Player's motions are impromptu and determine how competitive matches are played. Athletes can enhance their performance through a variety of training regimens. "Sprint Interval Training," for short bursts of maximal or supramaximal exercise, is one type of training used to improve sports performance. During recovering intervals, participants alternate between passive rest or light to moderately hard work. In both skilled and novice players, Sprint interval training significantly increases anaerobic and aerobic performance. This study aims to determine the impact of sprint interval training on hockey player's running performance, speed, and direction changes.

Field hockey is a team sport played with sticks and balls in which players' movements are spontaneous and dictate the fluctuating nature of competitive match play. A number of training programs are used to improve the performance of the athlete. One of the trainings that is used to enhance the performance of a sports person is "Sprint Interval Training" and it consists of short bursts of maximal or supramaximal exercise interspersed with passive rest or light to moderately intense exertion during rebound periods. Sprint interval training dramatically improves anaerobic and aerobic performance in both trained and untrained athletes. The aim of this study is to find the effect of sprint internal training on speed, change of direction and running performance among field hockey players.

A randomized controlled trial will be conducted at Pakistan Sports Academy, Lahore through non-probability convenience sampling technique on 28 players which will be allocated into both interventional and control group. Pre-training values of the players will be recorded by 20 m sprint test for speed, 505 Change of direction test for change of direction and 3000m time trial for running performance. Both groups will perform regular training. Sprint interval training will be given to Group A and regular training will be performed by Group B. Players will perform the training 3 times a week for 4 weeks and treatment evaluation will be done after 4 weeks. Data will be analyzed using SPSS software version 26. After assessing normality of data by Shapiro-Wilk test, it will be decided either parametric or non-parametric test will be used.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-30 years.
* Both males and females.
* Moderate level of training (Approximately 3 hours per week of activity).
* Playing experience of minimum 2 years.
* Being physically active in a self-reported manner (Approximately 150 minutes of physical activity weekly).

Exclusion Criteria:

* Systemic Conditions (unstable angina, systemic arterial hypertension, chronic obstructive pulmonary disease, diabetes mellitus, neoplasm, renal failure and sequelae of stroke).
* Any musculoskeletal issues that made it difficult to follow protocols or conduct testing.
Upper Extremity Pathologies in Spinal Cord Injuries

This study aims to determine the relationship between upper extremity pathologies and demographic data, duration of manual wheelchair use, duration of injury, physical examination and musculoskeletal ultrasound measurements in patients with spinal cord injuries.

Spinal cord injury is a neurological condition that can result from traumatic or non-traumatic causes, leading to motor, sensory and autonomic dysfunctions. Following a spinal cord injury, the upper extremity becomes increasingly used for mobility, weight-bearing, and transfer activities, making functionality crucial in daily life. Wheelchairs, commonly used by individuals with spinal cord injuries for daily activities, can lead to injuries and pain or degeneration in the upper extremities due to repetitive transfer activities. As a result, individuals with spinal cord injuries are at high risk for shoulder, elbow, wrist and hand injuries. Neuromuscular ultrasound (NMUS) has become increasingly important in clinical use in the evaluation of peripheral nerves and muscles in patients with spinal cord injuries in recent years, due to the advantages of ultrasonography such as providing dynamic and real-time evaluation, not containing radiation, and being painless.

This study aims to determine the relationship between upper extremity pathologies and demographic data, duration of manual wheelchair use, duration of injury, physical examination and musculoskeletal ultrasound measurements in patients with spinal cord injuries.

Eligibility Criteria:
Inclusion Criteria:

* Patients who have experienced spinal cord injury, can comply with two-stage verbal commands, voluntarily agree to participate in the study and are medically stable.

Exclusion Criteria:

* Tetraplegia
* A significant comorbid condition such as severe heart disease and uncontrolled hypertension.
* Cognitive dysfunction
* Active infection
* Malignancy
* History of trauma to the upper extremity
* Brachial plexus and peripheral nerve injury
* History of surgery on the upper extremity
Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

To describe the effect and mechanisms of action faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years).

The overall objective is to describe the effect and mechanisms of action of faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation in young adults (18 to 30 years). The specific objectives are to test the acute effects of different faba bean ingredient smoothie on: 1) post-prandial blood glucose, appetite, satiety hormone and insulin for 200 minutes, and 2) food intake 120 minutes following consumption of the faba bean smoothie. Two short-term acute studies will be conducted to meet these objectives. Both acute studies will follow a randomized, double blinded, balanced, repeated measures design and the same protocol; except one will have an ad libitum pizza meal (study 1), while the other will have a fixed pizza meal (study 2) at 120 minutes. Half the participants will have blood drawn by IV and the other half will be finger prick.

Eligibility Criteria:
Inclusion Criteria:

* healthy
* non-smoking males
* aged 20-30 years (min/max age)
* a body mass index between 20 and 25 kg/m2 (the range generally accepted as ideal/healthy by Health and Welfare Canada)

Exclusion Criteria:

* individuals diagnosed with diabetes
* those on medication
* breakfast skippers
* on an energy restricted diet
* this study excludes females because appetite and blood glucose during the female menstruation cycle changes due to fluctuations in hormones
COmbining Oral Letrozole and Clomiphene for Ovarian Stimulation

This is a pilot study evaluating the effect of a simplified low-cost (friendly) controlled ovarian stimulation using clomiphene citrate, letrozole, and low-dose hMG on the number of oocytes retrieved.


Eligibility Criteria:
Inclusion Criteria:

* Women scheduled to controlled ovarian stimulation for oocyte retrieval.
* Body mass index: 18-35 Kg/m2.
* Ultrasound scan up to the third day of a menstrual cycle with absence of a dominant and active follicle (follicle \>10mm and serum estradiol ≥ 40 pg/L).
* Signing an informed consent.

Exclusion Criteria:

* No exclusion criteria.
Simplified and Easy Detection of Arterial Disease in Nursing Homes

Peripheral artery disease (PAD) affects mainly elderly patients. The ankle brachial index (ABI) and ultrasound imaging are the standard diagnostic tools in PAD diagnostic and severity estimation. Measurements are generally performed by a vascular physician. However, access to medical specialist is becoming increasingly difficult with long waiting times while the aging of the population increases, while most of these patients are seen by the general practitioner.

To date, there is a lot of data in the literature on the value of using various ambulatory devices in the diagnosis and severity estimation of PAD but studied one by one.

The investigators propose to compare the measurements made by a series of simple non-invasive ambulatory tools with the measurements performed by the vascular specialist. The investigators wish to demonstrate that a series of simple and economical tools, available to paramedical health professionals can diagnose PAD and evaluate ts severity the reducing the direct and indirect associated costs.

Patients referred for an arterial vascular investigations of the lower limbs will be included.

After signing the consent, all included patients will be assessed by the examination series, among which ABI measurement and an arterial Doppler ultrasound of the lower limbs +/- transcutaneous oxygen pressure recording in case of suspected critical limb ischemia. Following the visit patients will be classified as have or not PAD and in case of PAD classified for the severity of PAD on the basis of the investigation results.

Blinded to the results of the vascular laboratory test, a technician will:

Measure ABI with an automatic sphygmomanometer.

Examination series:

1. Skin temperature on the back of the foot with infra-red thermometry
2. Toe saturometry
3. ABI with an automatic sphygmomanometry
4. Skin Recoloration time at the foot

Eligibility Criteria:
Inclusion Criteria:

* Patients referred for arterial assessment of the lower limbs as part of a screening or follow-up of PAD
* Patients without contraindications for all non-invasive measures
* Age superior to 18 years
* Affiliated patients of a social security scheme
* Patients who have signed informed consent.

Exclusion Criteria:

* Patients protected by law
* Patients unable to understand the objectives or instructions of the study
* Patients in an exclusion period relative to another biomedical study.
American Registry of Ambulatory or Acutely Decompensated Heart Failure

The purpose of this study is to better characterize and understand the population of patients with ambulatory or acutely decompensated heart failure in the American continent, getting to know their sociodemographic, clinical and paraclinical characteristics

An observational, prospective and multicenter study in which ambulatory patients with a confirmed diagnosis of heart failure and those admitted to the hospitalization service due to an episode of acutely decompensated heart failure will be invited to participate in order to better characterize this population

Participants who meet the eligibility criteria will be evaluated at the moment of recruitment. Follow-ups will be performed at 1, 6 and 12 months after the initial registry for hospitalized patients. For ambulatory patients follow-up will only be performed at 12 months. These initial evaluations and subsequents follow-ups will be carried out using a standardized form for the collection of hospital and outpatient data through an electronic platform

The purpose of this study is to know sociodemographic, clinical (clinical presentation, hemodynamic profiles, in-hospital and outpatient management, re-hospitalization rate, proportion of mortality, cumulative survival and heart failure readmission-free survival) and paraclinical characteristics of this population

Eligibility Criteria:
Inclusion Criteria:

* Patient aged 18 years or older and one of the following:
* Hospitalized patient with admission diagnosis of acutely decompensated heart failure or
* Outpatient with confirmed diagnosis (main or complementary) of heart failure

Exclusion Criteria:

* Hospitalized patient with principal diagnosis of another cardiovascular / non-cardiovascular pathology and who develops an acute decompensation of heart failure during hospitalization.
* Patient on heart transplant waiting list
* Patient who has implanted or is in process of implanting a long-term ventricular assist device (eg, Heart Mate II, Heart Mate III) as a target therapy or bridge therapy to other therapies
* Patient in whom palliative management has been previously defined for his/her cardiac condition (i.e. Heart failure) or for another associated medical condition (cancer, chronic obstructive pulmonary disease (COPD), etc.)
* Patient who is discharged or referred to another institution within 48 hours of hospital stay
* Inability to comply with programmed follow-ups (telephone or in person) due to social, personal or other conditions considered by the principal investigator
* Life expectancy less than 6 months given a condition other than heart failure (Cancer, COPD, etc.)
A Study to Evaluate the Relative Bioavailability and Intra-Subject Variability of Two Lots of E5501 40 mg Tablets Administered Twice as Single Oral Doses to Healthy Subjects

The purpose of this study is to evaluate the relative bioavailability (BA) of two lots of E5501 40 mg tablets administered twice as single oral doses to healthy subjects.

This is a randomized, open label, 4- way crossover, replicate design study to evaluate the bioavailability (BA) of E5501 new Phase 3 formulation Lot P97001ZZB 40 mg tablet manufactured July, 2009 (Treatment A ,reference drug) relative to Lot P01010ZZA 40 mg tablet manufactured January, 2010 (Treatment B, test drug) administered to 42 healthy male and female subjects.

Eligibility Criteria:
Inclusion Criteria:

* Normal healthy adult male or female subjects age greater than or equal to 18 years and less than or equal to 55 years old.
* Body mass index greater than or equal to 18 kg/m2 and less than or equal to 32 kg/m2 at the time of screening.
* Platelet count between 120x109/L and 250x109/L.
* Women of childbearing potential must agree to use a double barrier method of contraception during the Randomization Phase of the study.

Exclusion Criteria:

* Evidence of clinically significant cardiovascular, hepatic, gastrointestinal, renal, respiratory, endocrine, hematologic, neurologic, or psychiatric disease or abnormalities or a known history of any gastrointestinal surgery that could impact the pharmacokinetics (PK)of the study drug.
* Agents associated with thrombotic events (including oral contraceptives) must be discontinued within 30 days of the first study drug administration.
* Evidence of organ dysfunction or any clinically significant deviation from normal in their medical history, e.g., history of splenectomy.
* History of venous or arterial thrombotic disease or other hypercoaguable state.
* Hemoglobin level less than 11.5 g/dL for females and 13.5g /dL for males
Effects of Amlodipine/Benazepril in the Hypertensive African-American Population With Type 2 Diabetes Mellitus

This study evaluated the efficacy and safety of amlodipine/benazepril compared with that of enalapril in the treatment of hypertension in African-American patients with type 2 diabetes.


Eligibility Criteria:
Inclusion Criteria:

* African-American
* males and females
* current diagnosis of type 2 diabetes documented by medical history;
* mean sitting diastolic blood pressure of ≥ 90 and ≤ 110 mm Hg;
* HbA1C ≤ 9.5%

Exclusion Criteria:

* having unilateral or bilateral renal artery stenosis;
* having clinically significant cardiac dysrhythmias;
* having a significant history of coronary artery disease within the past 6 months;
* having a history or diagnosis of congestive heart failure (CHF);
* having any clinically relevant cardiac valvular disease
Combination of Almonertinib and Concurrent Chemoradiotherapy in Unresectable Stage III NSCLC

This is a Prospective, open, single arm study to evaluate the efficacy and safety of the almonertinib combined with concurrent chemoradiotherapy in unresectable stage III NSCLC with EGFR mutation


Eligibility Criteria:
Inclusion Criteria:

1. Age ≥18, male or female.
2. Patients must provide written informed consent to participate in the study.
3. Patients must have biopsy proven unresectable stage III NSCLC (AJCC 8th).
4. Patients must has sensitizing EGFR mutation (e.g. exon 19 deletion or exon 21 L858R).
5. Patients receiving almonertinib for 3 months and achieved stable disease, partial response or completely response.
6. ECOG score 0-1
7. Demonstrate adequate organ function Patients evaluated as Cr, PR and SD were given concurrent chemoradiotherapy 3 months after targeted therapy

Exclusion Criteria:

1. Patients progress in 3 months after almonertinib treatment
2. Patient can't tolerate radiotherapy or targeted therapy
3. Pregnant or nursing women
Evaluation of the Risk of Infection During Fever in Labor

* Fever during labor affects more than 8% of parturients. It is a heterogeneous entity and can be due to an infectious process, a side effect of a drug, or to labor itself (physiological hyperthermia).
* It has been the subject of several retrospective studies and a few prospective studies with varying methodologies, definitions, and inclusion criteria. None have proposed a combined obstetric, neonatal, infectious disease, and microbiological analysis.
* It raises concerns about the possibility of an emerging maternal (obstetric or otherwise) and/or fetal infection.
* Analysis of the available literature does not clarify the exact frequency of these infections or the predictive factors for their occurrence.
* It often justifies systemic antibiotic therapy, the modalities and benefits of which have never been evaluated.

The investigators aim to conduct a prospective multicenter study to analyze fever during labor with a combined obstetric, infectious disease, pediatric, and microbiological perspective.

The primary objective of this study is to analyze the causes of fever during labor by categorizing them into 3 etiological categories:

1. Fever indicative of maternofetal infection: potentially early intrauterine infection leading to proven or probable early-onset neonatal bacterial infection, endometritis, or maternal sepsis.
2. Fever indicative of maternal infectious pathology outside the obstetrical field (e.g., pyelonephritis, influenza, COVID, etc.).
3. Fever of non-infectious origin.

Secondary objectives include:

* Describing the epidemiology and local ecology of bacterial infections.
* Identifying predictive factors for each category (obstetrical infection, non-obstetrical infection, and non-infectious fever) when fever occurs during labor.
* Evaluating the maternal and neonatal prognosis of mother-child pairs who do not receive antibiotic treatment according to local protocols (e.g., in cases of fever below a threshold value).

Depending on the results and sample size, the study will also attempt to evaluate the maternal and neonatal prognosis of mother-child pairs in cases where fever is attributed to maternofetal infectious causes (category 1) according to the antibiotic management strategy for fever during labor at each center.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women at least more than 37 weeks
* Who have not opposed the collection of their health data for the purposes of studies and analyzes
* In work between 07/01/2023 and 06/01/2024
* Admitted to the work room at Port Royal, Necker Sick Children or Trousseau
* With fever defined as a tympanic temperature \> 38°C at least 2 times at 10 min intervals during labor.

Exclusion Criteria:

* Pregnant women :
* \< 37NT
* express their opposition to the collection of their data for research purposes
* minors or under legal protection
* context of medical termination of pregnancy or fetal death
Minimally Invasive or Conventional Edge-To-Edge Repair for Severe Mitral Regurgitation Due to Bileaflet Prolapse in Barlow's Disease: Does the Surgical Approach Have an Impact on the Long-term Results?

The study evaluates the long-term results of patients affected by bileaflet prolapse in Barlow's Disease, treated with edge-to-edge technique between 1997 and 2011.


Eligibility Criteria:
Inclusion Criteria:

Patients treated for bileaflet prolapse in Barlow's Disease between 1997 and 2011

Exclusion Criteria:

Age inferior to 18 years