cyrilzakka/clinical-trials huggingface dataset:
Avoiding Health Disparities When Collecting Patient Contextual Data for Clinical Care and Pragmatic Research

To assess whether the routine collection of patient-contextual data improves patient activation and communication, and can mitigate racial disparities in communication and engagement, we are inviting patients who have upcoming appointments at the participating health system to participate in a communication study. Patients will be randomized to having guided (facilitated) enrollment in a tool that collects patient contextual data, or to usual care. All patients are invited directly by the health system to use the tool. Statistical methods will be used to determine the impact of the tool's use on outcomes of interest, as well as the impact on completion by the use of the facilitated enrollment. The study will particularly focus on assessing the impact of patient-contextual data and communication on heath disparities.


Eligibility Criteria:
Inclusion Criteria:

* aged 18 or older
* able to speak and understand English,
* a patient at a selected Froedtert \& Medical College of Wisconson primary care or internal medicine clinic (i.e., General Internal Medicine On Campus of Milwaukee Regional Medical Center, Sargeant Health Center, or Tosa Health Center (Plank Road Clinic) with an upcoming (\> 4 weeks away) appointment and at least 1 previous appointment with the same provider in the previous 12 months.
* Patients with cognitive impairment (e.g. dementia) are eligible to participate through the use of proxies who would ordinarily accompany them to appointments and complete forms or post-visit surveys on their behalf.

Exclusion Criteria:

* Minors and non-English speaking patients are not eligible to participate
Near Infrared Fluorescent Imaging in Thyroid and Parathyroid Surgery With the Fluobeam(TM) System of Fluoptics

Hypothesis: Intraoperative use of near infrared fluorescent imaging technology and detection of Methylene Blue fluorescence will improve outcomes following thyroid and parathyroid surgery.

Aims: The aims of this phase of the study are to determine the feasibility of using near infrared fluorescent technology in the detection of parathyroid tissue and its differentiation from adjacent soft tissue during surgery on parathyroid glands.

Objectives of the phase I study:

1. To familiarise surgical teams with the intraoperative use of the 'Fluobeam(TM)' device (Fluoptics).
2. To understand the patterns (onset, intensity and duration) of fluorescent staining of normal parathyroid glands, thyroid glands and other soft tissue structures encountered during parathyroidectomy.

Further research:

This will be followed by a phase II study during which fluorescent imaging will be used in conjunction with intraoperative incremental dose of IV methylene blue in both thyroid and parathyroid surgery. Phase II will enable us to develop a protocol for the use of a minimum possible dose of MB for the identification of parathyroid glands. This will then be tested in the pilot phase of a randomized clinical trial.

As above

Eligibility Criteria:
Inclusion Criteria:

* all patients undergoing parathyroid surgery

Exclusion Criteria:

* patients undergoing re-do procedures
* patients unable to give adequate informed consent
* patients with a history of intolerance or sensitivity to MB
* patients with G6PD deficiency
* patients on serotonin reuptake inhibitors and patients undergoing thoracic exploration
* either alone or in combination with a neck exploration.
Evaluate the Efficacy and Safety of KI1106 in Patients Whose TG Level is Not Adequately Controlled With Atorvastatin Calcium Monotherapy While LDL-C is Properly Controlled

To examine variation rate of Non-HDL with KI1106 comparison Atorvastatin monotherapy.

Randomly assigned to two groups (KI1106 or Atorvastatin monotherapy) after 4 weeks run-in period and prescribed KI1106 or Atorvastatin for 8 weeks.

Eligibility Criteria:
Inclusion criteria:

* Screening Visit

  * Age: 20-80
  * High risk for cardiovascular disease according to NCEP APT III
  * TG≥300mg/dL and 160mg/dL\>LDL-C≥100mg/dL for subjects who were not taking statins for 4 weeks
  * 500mg/dL\>TG≥200mg/dL and LDL-C\<110mg/dL for subjects who were taking statins for 4 weeks
* Baseline Visit

  * 500mg/dL\>TG≥200mg/dL
  * LDL-C\<110mg/dL
  * Reduction of LDL-C comparing screening visit

Exclusion criteria:

* The patient has histories of acute artery disease within 3 months
* The patient has histories of operation revasculariation or aneurysm within 6 months
* The patient has histories of unexplained myalgia or diagnosed myalgia or rhabdomyolysis
* The patient has histories of effect able disease to the procedure and clinical trial result
The Efficacy of Neiguan (P6 Point) Acupressure in Patients With Gastroesophageal Reflux Disease (GERD)

In recent years, there is an increasing trend in the number of patients with Gastroesophageal reflux disease (GERD). The poor response to medicine was noticed in patients with non-erosive reflux disease. According to the theory of traditional Chinese medicine, acupuncture Neiguan (P6 point) could improve the uncomfortable symptoms of the chest and upper abdomen. Therefore, the aim of this study is to investigate the clinical efficacy of Neiguan (P6 point) acupressure in patients with GERD.

In recent years, there is an increasing trend in the number of patients with GERD. GERD mainly related to the reflux of stomach content induced by the dysfunction of lower esophageal sphincter. The common symptoms of GERD are heartburn, acid regurgitation, and chest pain. The methods to treat GERD are changes of lifestyle, pharmacotherapy, antireflux surgery and endoscopy. However, the poor response to medicine was still noticed in patients with non-erosive reflux disease. And long-term use of medicine will result in many side effects including infectious, abdominal pain, diarrhea and osteoporosis. According to the theory of traditional Chinese medicine, acupuncture Neiguan (P6 point) could improve the uncomfortable symptoms of the chest and upper abdomen. Therefore, the aim of this study is to investigate the clinical efficacy of Neiguan (P6 point) acupressure in patients with GERD. 64 patients with GERD were randomly divided into two groups：the acupressure and control. In the acupressure group, in addition to receiving standard treatment, patients will band a hand ring over Neiguan (P6 point) and acupressure for seven days. In the control group, in addition to receiving standard treatment, patients will band a hand ring but no acupressure for seven days. Data was collected by self-recorded symptoms before and after the intervention, according to the Reflux disease questionnaire(RDQ) and the World Health Organization Quality of Life Questionnaire Taiwan condensed version. Data was analyzed by Student's t-tests, Paired Student's t-test, Chi-square, and Fisher exact tests for quantitative and qualitative variables. We anticipate the treatment of Neiguan (P6 point) acupressure will reduce the symptoms of gastroesophageal reflux and improve the quality of life.

Eligibility Criteria:
Inclusion Criteria:

1. Male or female
2. Age of 20-60 years
3. Suffered from heartburn with or without acid regurgitation

Exclusion Criteria:

1. Suffered from peptic ulcer, gallstones, cancer, and Barrett's esophagus
2. previously underwent the esophagus, stomach or duodenum surgery
3. Lactating women or pregnant women
4. patients with severe cardiovascular disease
Aquagenic Pruritus in Myeloproliferative Neoplasms

Description of the characteristics of aquagenic pruritus expressed by patients suffering from myeloproliferative neoplasms.

Prospective work based on the distribution of a dedicated questionnaire.

Patients with myeloproliferative neoplasms identified and followed in French Hospitals. Patients could be followed for polycythemia vera or essential thrombocythemia or primary myelofibrosis.

Distribution of the questionnaire to each patient with myeloproliferative neoplasm (treated or not) suffering from aquagenic pruritus.

Analyse of each characteristic of the aquagenic pruritus by a statistician and publication at the end.

Eligibility Criteria:
Inclusion Criteria:

* Patients with one of three non-chromosomal Philadelphia-positive myeloproliferative neoplasms: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).
* Suffering (or having suffered) from aquagenic pruritus.
* No age limit, but major
* Patient having formulated his non-opposition

Exclusion Criteria:

* Patients with MPN with non-aquagenic pruritus,
* Patients with another hematologic disease and aquagenic pruritus
* Patients unable to complete the questionnaire.
* Patients with physical or mental disabilities to formulate non-opposition
* Refusal of participation
Lifestyle Intervention for Prevention of Gastric Neoplasm

The purpose of this study is to determine whether positive lifestyle interventions (diet modification and smoking cessation) are effective in the prevention of gastric pre-cancer and cancer occurrences and reccurence of gastric cancer after endoscopic resection.


Eligibility Criteria:
Inclusion Criteria:

* diagnosis of chronic atrophy gastritis proved by gastroscopy biopsy pathology or early gastric cancer patients who have recieved endoscopic resection
* have one or several bad lifestyle habits such as eating too much salt, eating too few fruits, smoking, drinking wine, and lack of sleep.

Exclusion Criteria:

* patients who refuse to change lifestyle according to the trial plan
Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy

This study is investigating whether administration of acetaminophen the day before surgery improves post operative pain following minimally invasive hysterectomy. Patients will receive either acetaminophen or placebo to take twice per day the day prior to their scheduled surgery. The morning of surgery all participants will receive oral acetaminophen at least 30 minutes prior to surgery. The investigators will examine whether there is a difference in post operative pain between the two groups.


Eligibility Criteria:
Inclusion Criteria:

* Undergoing minimally invasive hysterectomy for benign indications

Exclusion Criteria:

* acetaminophen allergy
* liver disease
* kidney disease
* consume \>3 alcoholic beverages per day
* weigh \<50 kilograms
* report daily opiate use
* contraindication to acetaminophen
* used acetaminophen within 24 hours of surgery
* undergoing a concomitant pelvic reconstructive procedure
Safety and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients

The primary objective of this study is to evaluate the pharmacokinetic profile of a single dose of intravenous ibuprofen administered over approximately ten (10) minutes.

The primary objective of this study is to evaluate the pharmacokinetic profile of a single dose of intravenous ibuprofen administered over approximately ten (10) minutes.

Eligibility Criteria:
Inclusion Criteria:

* Be a hospitalized male or female subject between birth (\> 37 weeks gestational age) and \< six (6) months of age.
* Have a clinical indication of pain or fever.
* Have written informed consent provided by legal parent, guardian, or authorized agent prior to participation in the study or performance of any study-only related procedures.

Exclusion Criteria:

* Have inadequate intravenous access.
* Have an uncorrected ductus dependent congenital heart disease.
* Have any history of allergy or hypersensitivity to non-steroidal anti-inflammatory drug or aspirin.
* Have a current history of uncorrected hypovolemia or acute renal disease.
* Have a current history of acute liver disease.
* Have received NSAID, acetaminophen, or aspirin drug therapy within four hours prior to dosing. Have received another investigational drug within the past 30 days.
* Be otherwise unsuitable for the study, in the opinion of the Investigator.
Satisfaction and Recovery After Trigger Finger Release

Trigger finger release is one of the most common procedures in hand surgery. However, little is known about the patient perceived outcome directly after surgery and the timespan to recovery of normal hand function.This study focuses on patient reported outcome scores within the first six weeks after surgery.

Patients scheduled for release of trigger finger are assessed regarding the following outcome measures:

1. VAS score for pain
2. VAS score for finger movement
3. VAS score for fréquence of triggering
4. HAKIR questionnaire (validated instrument for hand function in the Swedish national hand registry)
5. Quick-DASH questionnaire.

After surgery, the patients records the following outcomes:

Each day: 1,2,3 and records of pain medication details Each week: 4,5

for 6 weeks

Eligibility Criteria:
Inclusion Criteria:

1. Trigger phenomenon and/or
2. Tenderness volarly to MCP joint of affected finger/thumb
3. Patient scheduled for trigger finger release
4. Signed informed consent

Exclusion Criteria:

1. Concomitant hand injuries/ conditions
2. Multiple fingers/thumbs to be treated
3. Unable to read/understand instructions in Swedish
Observational Pilot Study of 18F-Sodium Fluoride (Na18F) Whole Body Positron Emission Tomography (PET) Scans for Imaging Bone

This study is being done to provide an alternative to bone scanning with technetium-99m (99mTc) labelled diphosphonates, and to document the safety of {18F}-Sodium Fluoride (Na18F) as a Positron Emission Tomography (PET) imaging radiopharmaceutical. Since the current availability of 99mTc was severely reduced because of the Chalk River shut down, alternative approaches to done scanning are needed. PET imaging with Na18F is one alternative approach to providing this critical clinical service.

18F-Sodium Fluoride (Na18F) PET imaging is a nuclear medicine procedure, and its principal radiopharmaceutical, Na18F, has been used for scanning the skeleton for the spread of cancer for more that 30 years, but has not been approved by Health Canada because less expensive alternate drugs have been available (99mTc diphosphonates). Given the sudden and drastic change in the availability of 99mTc, an acceptable alternative for 99mTc-diphosphonates is needed as soon as possible.

Eligibility Criteria:
Inclusion Criteria:

* Male or female patient for whom 99mTc-MDP bone scans would normally be indicated
* If female of child-bearing potential and outside the window of 10 days since the last menstrual period, a negative serum or urine pregnancy test is required.
* Age greater than or equal to 15 years
* Able and willing to follow instructions and comply with the protocol
* Provide written informed consent prior to participation in the study
* If an oncology patient, the patient should have a Karnofsky Performance Scale Score greater than or equal to 50

Exclusion Criteria:

* Nursing or pregnant females
* Ages less than 15 years
Impact of COVID-19 on Family Dynamics on Bandebereho Study Participants

This proposed study will assess how COVID-19 and the associated 'stay at home' orders are affecting low-income Rwandan couples' relationships and family dynamics. The study builds on an existing randomized controlled trial of the Bandebereho fathers/couples intervention (NCT02694627), which will allow us to assess not only the current conditions in households, but also whether or how the significant impacts of the intervention are sustained under extreme stress.

This proposed study will assess how COVID-19 and the associated 'stay at home' orders are affecting low-income Rwandan couples' relationships and family dynamics. It will contribute to documenting whether and how this disruptive moment might be changing or influencing relationship dynamics, conflict, and the distribution of care-work. We will build on an existing randomized controlled trial of the Bandebereho fathers/couples intervention, which will allow us to assess not only the current conditions in households, but also whether or how the significant impacts of the intervention are sustained under extreme stress. The Bandebereho fathers/couples intervention was implemented by the Rwanda Men's Resource Center (RWAMREC) and Promundo-US, in collaboration with the Rwanda Ministry of Health and local authorities in Karongi, Musanze, Nyaruguru and Rwamagana districts from 2013-2015. Results from a randomized controlled study of Bandebereho, a gender transformative intervention for expectant couples originally implemented in 4 districts in 2015, showed positive results across multiple outcomes after 21 months.

Eligibility Criteria:
Original inclusion criteria in the original RCT study included, for men: being between the ages of 21-35, expecting a child or having one or more children under the age of five, living in a stable partnership, and residing in the study site. For women, the criteria were simply being the partner of one of the men selected for the study.

Inclusion criteria for this study include previous participation in the RCT, and that the respondent indicated they or their partner owned a telephone/phone in the 21-month follow up that was conducted in November/December 2016. Based on data from the 21-month followup, approximately 80% of respondents reported a cell phone owned by them or their partner.
A Double-Blind, Placebo Controlled, Single, Escalating Dose Study to Evaluate the Preliminary Pharmacokinetics, Safety and Tolerability of LNK-754 in Healthy Elderly Volunteers

The objective of this study is to evaluate the single-dose plasma pharmacokinetics of LNK-754 as well as safety and tolerability in normal healthy male and female elderly volunteers


Eligibility Criteria:
Inclusion Criteria:

* Males and Females aged 60 to 75 years
* Good general health as determined by medical history and physical examination
* Body Mass Index of 18-32, inclusive
* Estimate of creatinine clearance by Cockcroft-Gault that is normal for age and sex (greater than or equal to 60mL/min)
* Normal hemoccult test at screening and baseline
* Voluntarily consent to participate in the study
* Willing to adhere to the protocol requirements

Exclusion Criteria:

* Subjects with clinically significant cardiovascular, pulmonary, renal, hepatic, gastrointestinal, neurological, sleep disorders by DSM-IV criteria, endocrine, hematological, or metabolic disease as determined by medical history and physical examination
* Subjects who have been diagnosed with or meet the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, Text Revision (DSM-IV_TR) criteria for any significant psychiatric or psychoactive substance use disorder within the past year
* Subjects with positive urine drug screen or compounds associated with abuse in the absence of medical justification for their presence
* QTcB greater than 450 msec (males), or greater than 470 (females), based on the average interval of triplicate ECGs obtained after five minutes rest in a supine position using hte ECG algorithm
* Clinically significant abnormal screening results or laboratory tests
* Pregnant or nursing or planning a pregnancy, or planning on fathering a child
EIT Assessment of Overdistension in ARDS Patients in Prone Position

Mechanical ventilation in ARDS requires protective ventilation with low VT and PEEP. PEEP titration can improve lung recruitment in the dependent lung but with a risk of overdistension in the non-dependant lung. EIT can measure the distribution of tidal ventilation and assess overdistension and collapse during a PEEP titration in any position (prone or not).

This study aims to measure the best PEEP as a compromise between recruitment and overdistension during a PEEP trial with EIT before and just after PP.


Eligibility Criteria:
Inclusion Criteria:

* Patients hospitalized in the ICU and who suffered moderate or severe ARDS (Berlin criteria, PaO2/FiO2\<150), intubated sedated, under myorelaxant and equipped with EIT
* Over the age of 18.

Exclusion Criteria:

* Broncho-pleural leaks
* Pregnant or breastfeeding woman.
* Guardianship or curatorship
* Deprived of liberty
* No health insurance
* Impossibility to correctly position the EIT belt (e.g., dressings, chest drainage, etc.)
* Contra indications to EIT (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions)
The Use of Drospirenone/Estetrol in Random Start Rapid Endometrial Preparation

The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety of drugs. We explored the efficacy of random started 14-day administration of drospirenone/estetrol, in rapid preparation of endometrium for hysteroscopic polypectomy.


Eligibility Criteria:
Inclusion Criteria:

* Patients with endometrial polyps.

Exclusion Criteria:

* Patients with other endometrial pathologies.
Relationship Between Vestibular Function and Topographic Memory

The purpose of this study is to evaluate visual and nonvisual topographic memory impairment and its relationship to vestibular function in humans. Topographic memory refers to the ability to remember current and past locations in topographic (navigational) space and to make and/or adjust to spatial transformations using such memories. Performance on each of these topographic memory tasks will be compared to performance on a set of comparable nontopographic memory tasks. Topographic impairments represent some of the earliest cognitive deficits observed in Alzheimer's Disease, and the brain areas involved in topographic memory are the first to show degenerative changes.


Eligibility Criteria:
Inclusion Criteria:

* Males or females of all racial and ethnic groups between the ages of 70 and 85 years of age;
* Montreal Cognitive Assessment (MOCA) (http://www.mocatest.org) score of \>24;
* No known history or current evidence of stroke, trauma, psychiatric illness, or other insult to the brain;
* No current use of psychoactive medicine other than caffeine (100 mg/day) or alcohol (1-2 drinks per night);
* Normal sleep (at least an average of 7 hours for four days prior to participation);
* Able and willing to comply with study requirements including following instructions to complete vestibular and neuropsychological testing; and
* Have full understanding of all elements of provide signature and dating of the written informed consent prior to the initiation of procedures specified in protocol.

Exclusion Criteria:

* \<70 or \>85 yrs of age;
* MOCA score of \<25;
* History, or current evidence, of stroke, trauma, psychiatric illness, or other insult to the brain;
* Prior history of inner-ear balance problems;
* Current use of psychoactive medicine other than moderate caffeine or alcohol use;
* Acute or chronic sleep deprivation during the week prior to participation (\<7 hours/night on average for four nights prior to participation).

Other Restrictions:

* No alcohol use on the night before the vestibular testing
* 7 hours minimum sleep the night before vestibular testing
* No eye make-up can be worn on the day of the vestibular test due to possible interference with vestibular-ocular reflex testing apparatus