cyrilzakka/clinical-trials huggingface dataset:
Evaluating the Fluid Balance of Mechanically Ventilated Patients by Ultrasonography

ratio of the diameter of inferior vena cava to the diameter of the thoracic aorta (IVC / Ao) depends on the daily balance of fluids.

During the routine abdominal ultrasound, the basilar and abdominal aorta were measured using a Sparq Philips ultrasonograph with a convex probe set in abdominal mode. All measurements were performed in one patient by the same operator who were experienced and performed the appropriate course of ultrasonography. The IVC and abdominal aorta were visualized using a paramedian long-axis view via a subcostal approach according to the methodology described by the American Society of Echocardiography. Inferior vena cava width was assessed at an interval of approximately 1 cm distal from connection of the hepatic vein to the inferior vena cava. No significant changes were observed in the width of the inferior vena cava during various respiratory phases, because of the positive pressure ventilation. The widest value was always chosen for the data. The assessment of the width of the abdominal aorta was performed above arise of the celiac trunk, at the height of the vein of the lower vena cava. The width of the inferior vena cava and the abdominal aorta was assessed using transthoracic ultrasound for the following five days. Daily differences in the amount of fluid intake and lost was recorded. CVP measurement was performed.

Eligibility Criteria:
Inclusion Criteria:

* patients who were hospitalized in the Intensive Care Unit
* severe respiratory failure requiring mechanical ventilation

Exclusion Criteria:

* spontaneous breathing,
* severe vascular disease,
* increased intra-abdominal pressure,
* cardiac pacemaker
* cardioverter defibrillator
Evaluation of Duloxetine and Innovative Pelvic Floor Muscle Training in Women With Stress Urinary Incontinence

This study will evaluate the safety, tolerability and efficacy of duloxetine and pelvic floor muscle training in women who suffer from stress urinary incontinence

This is a randomized-intervention, parallel, multicentric study which will evaluate the safety, tolerability and efficacy of oral duloxetine and innovative pelvic floor muscle training to woman suffering from stress urinary incontinence

Eligibility Criteria:
Inclusion Criteria:

* Woman's willing to provide written informed consent
* Women over 18 years that experience uncomplicated stress urinary incontinence
* Score of the International Consultation on Urinary Incontinence Questionnaire ≥ 14 points
* Symptoms of urinary incontinence for at least 3 consecutive months
* Have at least seven urinary incontinence episodes per week
* Degree of pelvic organ prolapse ≤ 2 stage
* Willingness to accept the randomization process and fully participate in tests

Exclusion Criteria:

* Recent use of any pharmacologic agent used to treat symptoms of urinary incontinence in the past six months
* History of anti-incontinence surgery in the past 12 months
* Use of onabotulinumtoxinA for the treatment of urinary incontinence in the past 12 months
* History of pelvic prolapse repair or urethral surgery in the past 12 months
* History of pelvic floor muscle training in the past 12 months
* History of interstitial cystitis or bladder-related pain
* Chronic severe constipation
* Clinically significant renal or hepatic impairment
* Clinically significant heart impairment
* Pregnant woman, lactating, or actively trying to become pregnant
* Non-compliance with limitation of duloxetine treatment for mixed urinary incontinence
* Positive urinary tract infection
* Use of rehabilitation aids (pessary, urethral plugs, vaginal beads, etc.)
* Use of antidepressant therapy
* Insufficient understanding of pelvic floor exercises and/or omitting exercises
* Participation in any clinical study in the past six months
Electrocautery Versus Scalpel for Skin Incisions

The aim of this research project is to compare electrocautery to scalpel for laparotomy skin incisions, with the following objectives:

1. To investigate whether electrocautery produces a cosmetically inferior surgical scar.
2. To compare the rates of wound infection with each technique.
3. To determine if electrocautery results in less postoperative pain. Our null hypothesis is that electrocautery is equivalent to scalpel for creating skin incisions; with respect to wound cosmesis, wound infection rate, and post-operative pain.


Eligibility Criteria:
Inclusion Criteria:

* Patients over 19 years old
* bowel resection surgery
* incision is 3cm or larger

Exclusion Criteria:

* Diagnosed with a connective tissue disease (e.g. Systemic lupus, scleroderma, polymyositis, dermatomyositis, Marfan syndrome, Ehler's Danlos, etc.)
* The site of planned surgery has a previous surgical scar.
Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain

The main purpose of this study is to assess conception, pregnancy, childbirth, and pain experiences among women who have been diagnosed with vulvodynia. Specifically, this study aims to examine the following among women who have been diagnosed with vulvodynia: 1) rates of pregnancy/childbirth and desire for children; 2) fear of pregnancy and childbirth; 3) potential difficulties experienced while attempting to become pregnant and during pregnancy/childbirth; 4) methods used to become pregnant and deliver; 5) methods used to manage vulvodynia symptoms during pregnancy; and 6) pain outcomes associated with pregnancy.

Very little research has examined pregnancy/childbirth experiences among women with vulvodynia, or the natural history of vulvodynia. As such this is a preliminary investigation that will provide descriptive information regarding many of the proposed research questions. Based on the clinical experience of the investigators, it is expected that women with vulvodynia will report lower rates of pregnancy and higher levels of fear about pregnancy and childbirth in comparison to women without such pain. It is also expected that women with vulvodynia will report more difficulties becoming pregnant as compared to women without such pain, and that women with vulvodynia will report more elective nonvaginal births in comparison to vaginal births.


Eligibility Criteria:
Inclusion Criteria:

* previous diagnosis of vulvodynia from a physician (women with vulvodynia only)
* assessed and/or treated at one of 3 clinics (women with vulvodynia only)
* free from chronic vulvar pain and pain with sexual intercourse in their lifetime (control women only)
* 19 years of age or older
* fluent in English

Exclusion Criteria:

* younger than 19 years of age
* lack of fluency in English
Combining Chinese Medicine and Nutrition to Enhance Weight Loss After Bariatric Surgery

This study aims to investigate the effects of Chinese herbal granule preparations on improving gastrointestinal symptoms in patients after bariatric surgery. It seeks to establish a novel treatment model that combines bariatric surgery with traditional Chinese medicine, providing clinical practice with additional evidence-based medical support.


Eligibility Criteria:
Inclusion Criteria:

1. BMI ≥ 27.5 kg/m²;
2. Undergoing metabolic bariatric surgery;
3. Traditional Chinese Medicine syndrome differentiation classified as Spleen Deficiency and Excess Dampness syndrome.

Exclusion Criteria:

1. Contraindications for metabolic bariatric surgery;
2. Type 1 diabetes;
3. Complicated by other significant systemic diseases, such as severe liver and kidney diseases, malignant tumors, psychiatric disorders, etc;
4. Concurrent use of other medications or treatments that may affect body weight, such as metformin, semaglutide, endoscopic interventions, etc;
5. Pregnant or lactating women.
Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

The goal of this study is to demonstrate the efficacy of a multidisciplinary group-based telehealth intervention (HORIZONS) compared to minimally enhanced usual care for improving self-management and quality of life for hematopoietic stem cell transplant (HSCT) survivors living with chronic graft-versus host disease, and to identify critical facilitators and barriers for HORIZONS implementation and adoption.

This is a randomized clinical trial to determine whether a multidisciplinary group-based telehealth intervention is effective at improving the quality of life and reducing psychosocial distress in patients living with chronic graft-versus-host disease. The HORIZONS intervention was developed with the goal of improving the experience and needs of patients living with chronic graft-versus-host disease.

Participants will be randomized into one of the two study groups: HORIZONS plus usual care or minimally enhanced usual care.

Participation in this study is expected to last up to 18 weeks after enrollment.

The investigators expect that about 350 adult allogeneic hematopoietic cell transplant recipients with moderate to severe chronic graft versus host disease will take part in this research study.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients (≥ 18 years) who have undergone allogeneic HCT
* Have moderate to severe cGVHD based on patient-report
* Have ability to participate in English or Spanish language group telehealth intervention.

Exclusion Criteria:

* Patients with mild cGVHD based on their self-report.
* Patients with a major untreated psychiatric or cognitive condition which the treating oncology clinicians believes interferes with the capacity to provide informed consent.
Support Group Surveys for Individuals Who Have Type 1 Diabetes and an Eating Disorder

We propose to conduct a monthly group of persons with type 1 diabetes who also withhold insulin. Subjects will be asked to complete a 2-page survey (check-in sheet) at the beginning of each session and a 5-page survey (Diabetes and Eating Disorders Survey) on their first session and at their last session of their group.


Eligibility Criteria:
Inclusion Criteria:

* Have an eating disorder
* Have type 1 diabetes
* Withhold their insulin
* 18 years or older
* Actively being treated at EDI
* Committed to at least one appointment each month with each member of their individual EDI team (RD, CDE or RN, CDE; LP; and MD)
* Approval of participation by EDI/DM team (RD; RN; LP; MD)
* Able to attend 66% of group sessions

Exclusion Criteria:

* Psychologically not ready for this group therapy
* Have additional eating disorder issues that would make attendance in this group inappropriate
* Not committed to continuing treatment at PN's EDI
* Not being actively treated at PN's EDI
* Has type 2 diabetes
Granulocyte Colony Stimulating Factor Versus Platelet Rich Plasma and Outcomes of Frozen Embryo Transfer

The rationale behind this current study is to assess the impact of using PRP versus GCSF on the outcomes of frozen embryo transfer in term of clinical pregnancy rates.

INTRODUCTION AND STUDY RATIONALE Despite the advancements in the treatment of infertility, repeated failure of implantation continues as a challenging difficulty.

Embryo implantation is affected by many factors. Many efforts were made to improve the implantation rate by different methods blastocyst transfer, assisted hatching, preimplantation genetic screening, hysteroscopy, removal of hydrosalpinges and endometrial scratch. Furthermore, infertility specialists suggested some empirical methods like the infusion in the uterine cavity of platelet-rich plasma (PRP) in patients with thin endometrium which has been shown to be effective in improving the pregnancy rate.

Another factor is granulocyte colony stimulating factor (G-CSF) which has receptors in endometrial cells and may have a role in implantation. The use of G-CSF in assisted reproductive technology (ART) has been tried by many research studies either via intrauterine or systemic administration.

There is only one study compared the impact of PRP and GCSF administration on the pregnancy rate and on the endometrial thickness with a small sample size.

The rationale behind this current study is to assess the impact of using PRP versus GCSF on the outcomes of frozen embryo transfer in term of clinical pregnancy rates.

STUDY OBJECTIVES

Primary:

The primary objective of the study is to compare the clinical pregnancy rate determined by presence of fetal heart beat in transvaginal ultrasound after embryo transfer in all groups.

Secondary:

To compare the following in the three study arms:

* Chemical pregnancy determined by positive serum β-HCG, 2 weeks after embryo transfer.
* Clinical pregnancy rate adjusted by the endometrial thickness (thin versus normal) in all groups.
* Clinical pregnancy rate adjusted by PGS in all groups
* The midluteal endometrial thickness in all groups (histopathology \& TVUS).
* The number of women who had thin endometrium and reaches endometrial thickness ≥ 7 mm after using G-CSF or PRP.
* Implantation rate
* Miscarriage rate
* Live-birth rate

Eligibility Criteria:
Inclusion Criteria:

* All women aged 20-40 years
* non-smoker
* BMI \< 30
* Normal endometrial cavity confirmed by hysteroscopy
* Visiting the center for IVF by frozen embryo transfer during the period of the study

Exclusion Criteria:

* History of anti-phospholipid syndrome confirmed by serological tests.
* History of any hematological and immunological disorders
* History of chromosomal or genetic abnormalities in the patient or in the family
* Any uterine abnormalities (congenital or acquired)
* Previous uterine surgeries except caesarean section
* Hypersensitivity to G-CSF
* Uncontrolled systemic disease
Community First Responders' Role in the Current and Future Rural Health and Care Workforce

Community First Responders (CFRs) are trained members of the public, lay people or off-duty healthcare staff who volunteer to provide first aid. CFRs help ambulance services to provide care for people having health emergencies, from falls to road accidents to heart attacks, at home or in public places. CFRs are particularly important in rural areas where it is more difficult to provide or access emergency care, and where they are an important part of the care workforce. CFRs are broadly perceived to be positive, however evidence is needed about how they contribute to rural health services, which patients/conditions they attend, what care they provide, how effective they are and at what cost, how they are perceived by patients and other health workers, and how they could be developed to improve care for rural communities.

The investigators aim to develop recommendations for rural CFRs, by exploring their contribution to rural care, evaluating their value for money, understanding experiences and views of patients, CFRs and other healthcare staff, and exploring the potential for CFRs to provide new services.

The project will involve the following steps:

1. Analyse records from six ambulance services to see: how many people CFRs attended; the proportion of ambulance calls attended; age, sex and conditions of people attended; how quickly CFRs attended and what happened to the patient(s) when the ambulance arrived.
2. Evaluate benefits and costs of CFRs attending rural emergencies.
3. Interview patients/relatives, ambulance staff, GPs, funders, CFRs and CFR leads to obtain views on rural CFR current and potential future roles. Interviews will also explore with CFRs and CFR leads, challenges and solutions to recruiting, training, retaining rural CFRs and ensuring safe, high quality care.
4. Combine this knowledge (gained in steps1-3 above) to develop recommendations for change; who will be involved and how services should change to solve the most pressing problems for the rural communities served.
5. Present recommendations to a workshop of experts and public to agree priorities for future development.

Eligibility Criteria:
Inclusion Criteria:

* Adults capable of giving informed consent. The investigators will recruit a maximum variation sample of patients (according to age, sex, condition, and ethnicity), ambulance staff (sex, experience, ethnicity and role), CFR (sex, ethnicity, length of experience, skill level) and CFR scheme leads (independent charity and ambulance trust overseen schemes).

Exclusion Criteria:

* The investigators will exclude children and adults who are unable to give informed consent from this study.

London Ambulance Service NHS Trust is not included as it is mainly urban; East of England Ambulance Service and North East Ambulance Service are not included because of lack of electronic data.
NARCOMS Registry: a Multiple Sclerosis Registry

This project is based on the idea that we can learn about the complexities of MS by following disease and treatment patterns in a large group of people over several years. The information gathered is used for research only. Results are presented in summary form only. All details submitted by registry participants is strictly confidential.

To participate in NARCOMS complete the baseline enrollment survey online through www.narcoms.org (or directly using the following link: https://redcap.link/py2rnyyn) or you can request a mail-in survey be sent to you by emailing MSregistry@narcoms.org. You will be asked to update your information, online or by mail, twice a year. Each update survey typically takes less than 20 minutes to complete.

There is no cost to participate. For your participation you are offered a free subscription to the NARCOMS quarterly magazine, NARCOMS Now. NARCOMS Now provides a reliable source of information about the latest in MS research and disease management. You can stop participating in the registry at any time.

You may also receive additional surveys or information on clinical trials. You are not obligated to participate and these additional studies will always come directly from NARCOMS. Your contact information will not be shared or sold to other parties.

The data coordinating center, located at the University of Texas Southwestern Medical Center, maintains NARCOMS, the worlds largest voluntary, patient driven MS registry. The registry involves personnel from at least three other sites in the US and Canada (Cleveland Clinic Foundation, University of Alabama at Birmingham, and the Dalhousie University in Canada). Over the past 20 years more than 41,000 people with MS across the U.S., Canada and over 50 other countries, including over 4,000 Veterans, have participated in the registry by submitting their health-related data by mail or online. Registry data have been featured in over 100 peer-reviewed journal articles, scientific posters and presentations. These reports have provided information to guide new research. They also provide evidence supporting the approval of new drugs in the fight against MS.

The North American Research Committee on Multiple Sclerosis (NARCOMS) is supported in part by the Consortium of Multiple Sclerosis Centers (CMSC), a not-for-profit professional organization for multiple sclerosis (MS) healthcare providers and researchers involving 198 participating centers of the MS treatment and research community.

Eligibility Criteria:
Inclusion Criteria:

* Any individual who has been diagnosed with multiple sclerosis or clinically isolated syndrome
* Must be at least 18 years of age

Exclusion Criteria:

* None
Clinical Investigation on the Blood Oxygenation at the Optic Nerve Head in Fabry Patients

This study aimed to evaluate blood oxygenation at the optic nerve head in relation with visual field losses observed in many Fabry patients. Data collected allowed to evaluate if there is a link between these two entities.

Study lasted 2 years during which a limited number of Fabry patients had been compared to a control group to confirm any relationship between blood flow and field losses, and to see if these results varied over time.

HYPOTHESIS

1. Fabry patients will present significant differences in visual fields compared to control 2 There will be variability of the visual field defects on the long term but not on the short term 3 Blood oxygenation will be higher for Fabry patients 4 Blood volume at the optic nerve head will be the same for both groups.

The first subjects who meet the following criteria will be enrolled in the study.

Inclusion criteria (Fabry group ):

* Aged over 18 years old
* Being diagnosed with Fabry disease

  * 3 subjects will be under enzyme replacement treatment for the treatment of Fabry disease.
  * 3 subjects will not receive enzyme replacement treatment
* Is fit to give legal consent.
* Is available for a period of 2 years

Inclusion criteria (CONTROL group ):

* Matched for age and sex with group A - 6 participants
* Being healthy, with no known chronic systemic disease nor acute disease at the moment of the recruitment
* Is fit to give legal consent.
* Is available for a period of 2 years

Exclusion criteria (Both groups):

* Presents with an active pathological ocular condition
* Presence of an abnormal optic nerve (congenital or acquired)
* Usage of topical ocular drug(s) at the time of selection
* To have known allergy to topical diagnostic drugs used in this study
* Usage of systemic medication with known effect on the visual field

Eligibility Criteria:
Inclusion Criteria:

Inclusion criteria (Fabry group):

* Aged over 18 years old
* Being diagnosed with Fabry disease

  * 3 subjects will be under enzyme replacement treatment for the treatment of Fabry disease.
  * 3 subjects will not receive enzyme replacement treatment
* Is fit to give legal consent.
* Is available for a period of 2 years

Inclusion criteria (CONTROL group):

* Matched for age and sex with group A - 6 participants
* Being healthy, with no known chronic systemic disease nor acute disease at the moment of the recruitment
* Is fit to give legal consent.
* Is available for a period of 2 years

Exclusion Criteria:( both groups):

* Presents with an active pathological ocular condition
* Presence of an abnormal optic nerve (congenital or acquired)
* Usage of topical ocular drug(s) at the time of selection
* To have known allergy to topical diagnostic drugs used in this study
* Usage of systemic medication with known effect on the visual field
Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM

The aim of this study to compare vaginal progesterone supplementation to cervical cerclage for prevention of preterm labor in women with short cervical length and history of previous midtrimester miscarriage and/or preterm labor.

Women with singleton pregnancy and history of preterm labor and/or midtrimester miscarriage in a previous pregnancy will be selected for serial assessment of the cervical length by transvaginal sonography (TVS) starting from 16 weeks till 24 weeks of gestation. Eligible participants in our study will be those who have cervical length of 15-25 mm at 16-24 weeks of gestation. At 16-24 weeks gestational age, all women participating in the study will be randomly allocated into two groups; progesterone group and cerclage group. For women in the progesterone group, vaginal progesterone suppositories will be given in a dose of 400 mg/day. For women in the cerclage group, McDonald cervical cerclage will be performed.

Eligibility Criteria:
Inclusion Criteria:

* Women with singleton pregnancy.
* History of preterm labor and/or midtrimester miscarriage in a previous pregnancy.
* Cervical length of 15-25 mm by transvaginal sonography (TVS) at 16-24 weeks of gestation.

Exclusion Criteria:

* Age \< 20 or \> 35 years.
* Congenital uterine malformation.
* Multifetal pregnancy.
* Known major fetal structural or chromosomal abnormality.
* Known allergy or contraindication (relative or absolute) to progesterone therapy.
* Presence of contraindication to cervical cerclage.
* Medical conditions complicating pregnancy.
* Vaginal bleeding.