cyrilzakka/clinical-trials huggingface dataset:
Cardiopulmonary Resuscitation Self-training

Participants were 45 first-year medical students randomly assigned to cardiopulmonary resuscitation (CPR) self-training using either a video-based presentation or a serious game developed in a 3D learning environment for up to 20 min. Each participant was evaluated on a written, multiple-choice test (theoretical test) and then on a scenario of cardiac arrest (practical test) before and after exposure to the self-learning methods.

A prospective, simulation-based, randomised controlled trial was conducted. Participants were randomised to the video group watched a video-recorded lecture on the management of adult cardiac arrest, while participants randomised to the game group played a serious game on the same topic.

The video was developed based on a previously recorded Keynote presentation (version 6.6.2, Apple Inc.) with the addition of voice-over narration of the events. The video was edited to contain the same information as provided in the serious game. The learning environment simulated an urban public space where the player should identify a victim of cardiac arrest and perform CPR manoeuvres. The game was designed to be a CPR self-learning tool for both health professionals and the lay public. The game involved only one rescuer without access to a portable defibrillator. During the game, the player should identify the victim, diagnose cardiac arrest correctly and initiate CPR as early as possible. The actions of the player were guided throughout the game by step-by-step instructions that should be followed to save the victim's life and to score on the game. Whenever the manoeuvres were not performed correctly, the victim died and the game automatically restarted from the beginning.

After exposure to the self-learning methods, participants were reassessed individually for their theoretical knowledge on a written, 10-question, multiple-choice test (theoretical post-test) and for their practical performance by three examiners, blinded to group assignment, who independently rated the participants' actions on a 10-min simulated scenario of cardiac arrest using a CPR training manikin (practical post-test).

Simulated scenario The same simulated scenario was used for pre-exposure and post-exposure practical evaluation. When the student entered the simulation room, a manikin was lying on the floor, simulating a person lying on the street, unconscious, not responding to stimulation and with no respiratory effort or pulse. The student was alone without access to medical equipment such as a defibrillator. Participants were expected to recognise the cardiac arrest, call the emergency services, and initiate chest compressions and ventilations as soon as possible for at least two cycles. A 10-min time limit was set for each simulation session.

Eligibility Criteria:
Inclusion Criteria:

* Being a medical student;
* Voluntary participation;
* No previous participation in CPR training.

Exclusion Criteria:

* Previous participation in CPR training.
* Refusal to participate.
* Not being enrolled in medical school.
Immediate Stiffness Changes in Myofascial Trigger Points After Dry Needling

Shear-wave elastography (SWE) is considered as a useful tool for quantifying muscle stiffness. Considering that Myofascial Trigger Points (MTrP) are defined as "hyperirritable zones in contracted bands of muscle, thought to be caused by muscle overload or stress" and the effectiveness of dry needling applied to active MTrP for reducing pain and disability, the aim of this study is to assess the effects of sham and real dry needling, applied to active MTrP in the upper trapezius muscle in patients with chronic neck pain, on the muscle stiffness in two areas: 1) the most symptomatic area and 2) a control point.


Eligibility Criteria:
Inclusion Criteria:

* Patients between 18 and 65 and
* Presence of mechanical neck pain for at least three months duration
* Presence of at least one active MTrP in the Upper Trapezius muscle

Exclusion Criteria:

* Neck pain of traumatic origin (such as whiplash-associated disorder)
* Current use of any kind of analgesic therapy
* Presenting any condition usually considered a perpetuating factor of MTrPs, such as fibromyalgia, hypothyroidism, or iron deficiencies
* Presenting any contraindication for Dry Needling application
* Neuropathies (e.g., radiculopathy)
* Bilateral Pain
Compare Pharmacokinetics and Safety of JP-1366 Between Korean and Caucasian

To evaluate the effect of coadministration of aceclofenac, meloxicam and naproxen on pharmacokinetic interactions and safety of JP-1366 in healthy Korean subjects and to compare the pharmacokinetic nature and safety of JP-1366 between healthy Korean and Caucasian.


Eligibility Criteria:
Inclusion Criteria:

* Subject who has fully informed about this study and understand co mpletely, decide to participate voluntarily and agree with the writte n consent before screening test.
* A healthy volunteer in the age of upper 19 at the time of the scree ning test.
* Subject whose BMI was 18.0 or more and 30.0 or less and whose b ody weight was 50kg or more if in male, and 45kg or more if in fe male at the same time.
* Caucasian in Part 4 who has medical interview and documents(passport, birth certificate) or signatured conformation by the subject.

Exclusion Criteria:

* The Subject who has clinically significant diseases with liver, kidney, nervous system, digestive system, immune system, respiratory system, and endocrine system, musculoskeletal system or the blood or tumor disease, cardiovascular disease (including orthostatic hypotension), mental disorder or with history of the disease.
* The subject who has a history of gastrointestinal disorders (gastrointestinal ulcers, gastritis, gastric ulcer, gastroesophageal reflux disease, Crohn's disease, etc.) or history of gastrointestinal surgery that may affect the safety and PK/PD Evaluation of the investigational product (Except for simple cecal surgery and hernia surgery)
* The subject who has a hereditary disorder (galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption etc.).
* The subject who has a history of an active peptic ulcer or bleeding.
* Screening laboratory test showing any of the following abnormal laboratory results: ALT, AST, Total bilirubin \> 2.0 x ULN - e-GFR \< 60 mL/min/1.73m2 (CKD-EPI formula) - Positive result for Serological test (HBsAg, HCV Ab, HIV Ab, Syphilis regain test)
Observational Study on Predictors of Response to Invirase (Saquinavir) Treatment in Treatment-naïve Patients With HIV Infection

This prospective observational study will evaluate predictors of response to Invirase (saquinavir) treatment in treatment-naïve patients with HIV infection. Data will be collected during 48 weeks of treatment.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients, \>/= 18 years of age
* HIV infection
* Treatment-naïve
* Initiation of treatment with Invirase

Exclusion Criteria:

* Contraindications according to Invirase Summary of Product Characteristics
Outcome Study of Patients Treated With Translational Cervical Plate Used to Treat Degenerative Disc Disease

The purpose of this study is to measure the benefits of anterior (from the front) cervical (neck) surgery for degenerative disc disease. The research part of this study is the answering of questionnaires by the patient concerning their quality of life, prior to, and after surgery.

This is a prospective, multi-center, four-arm study designed to evaluate the clinical and radiographic outcomes in patients diagnosed with cervical degenerative disc disease (DDD) and treated using the Vectra-T Cervical Plate and the Advanced ACF or CorticoCancellous Allograft Spacer made by Synthes Spine Company (Paoli, PA). This is not an investigational study (IDE) and no investigational or experimental devices or procedures are included in this study.

Eligibility Criteria:
Inclusion Criteria:

* One to four levels (consecutive) cervical degenerative disc disease between C2 and C7, defined as at least one of the following:

  * disc herniation
  * axial neck pain (with or without radiculopathy or myelopathy) caused by spondylosis
  * functional deficit
  * neurological deficit which significantly limits patient's normal living
* One to four cervical levels to be plated
* Patient is skeletally mature and at least 18 years of age
* Patient signs consent form
* Patient is available for long term (24 month) follow-up
* Etiology must be confirmed by MRI or CT

Exclusion Criteria:

* Spondylolisthesis greater than grade 1 at either level(s) to be instrumented
* Indications for complete corpectomy of any involved levels
* Posterior instrumentation is necessary at same levels
* More than one previous failed anterior fusion attempt at the involved level(s)
* Has had more than one previous open, posterior, spine surgical procedures at the involved level(s) or pre-op instability on Flexion/Extension radiographs.
* Pregnant or interested in becoming pregnant during the study follow-up period
* Has a known sensitivity to device materials
* Mentally incompetent or prisoner
* Currently a participant in a study related to the treatment of cervical spinal disorders
* Pre-op instability\>3mm on flexion/extension X-rays
Voiding Diary Video

The aim of this study is to evaluate patient adherence and completeness of intake and voiding diaries. The secondary goal is to compare the satisfaction and understanding of patients of the intake and voiding trial diaries directions.

This is a randomized prospective study. All women who need to complete an intake and voiding diary at the Yale Urogynecology outpatient facilities will be invited to participate. After completion of the consent process, they will be randomized to one of two groups. Both groups will have their voiding diaries analyzed by three blinded experts and will be graded on completeness of the information filled out. The mean grade obtained from this process and the return rate of the voiding diaries will be the primary outcomes. The secondary outcomes will include a brief patient questionnaire on their satisfaction of the instructions with the voiding diary. The primary and secondary outcomes will be evaluated between the groups to determine the effectiveness of the video intervention.

Eligibility Criteria:
Inclusion Criteria:

* Need for intake and voiding diary completion
* Deemed to required return visit or follow up
* Able to read and write English

Exclusion Criteria:

* Dementia
* Prisoners
* Pregnant Patients
* Medical and physical handicaps which may interfere with completion of intake and voiding diary
* Medical and physical handicaps with viewing or understanding of the educational video
* Illiterate patients
* Patients who cannot speak and understand English
Physical Activity Counseling After Bariatric Surgery

This study will examine whether providing physical activity counseling and guidance to patients post bariatric surgery, along with long-term personal follow-up for six months after the surgery, may increase the level of physical activity, and it's effect on anthropometric and functional measures.

Bariatric surgery is considered to be most effective in treating morbid obesity for patients with BMI≥40 or BMI≥35 with comorbidity for obesity.

postoperative weight loss following any type of bariatric surgery is largely dependent on the extent to which patients can make and sustain changes in their eating habits and activity level. Adopting physical activity habits can help to optimize outcomes after bariatric surgery, such as contributing to the rate of weight loss after the surgery and maintain lean body mass.

In order to successfully implement a behavioral change regarding the adaptation of healthy lifestyle habits in obese patients, it is vital to promote physical activity counseling after the surgery, and to find an effective intervention that can support habitual physical activity.

The aim of this trial is to examine the effect physical activity counseling after bariatric surgery on the amount and intensity of activity performed, quality of life, anthropometric and functional measures during the first year after surgery.

Up to eighty Participants will be recruited for the trial, and will be randomly assigned to one of the two study arms (Control, Intervention). The intervention group will receive physical activity counseling and guidelines for the following six months after the surgery.

All participants will receive a pedometer to track daily steps for 7 days at different time points before and after the intervention. Additional Measurements will be taken at a pre-surgical baseline assessment and throughout the trial, and will include anthropometric measures (Weight, BMI, and body composition) and functional measures (Handgrip, 6-minute walk test, chair stand-up test).

All participants will fill out a the 7-day international Physical Activity questionnaire, Self-efficacy for physical exercise scale, and SF-36 questionnaire, before and after the intervention.

Eligibility Criteria:
Inclusion Criteria:

* BMI ≥ 40 kg/m2 or 35 kg/m2 with comorbidities
* 18 to 50 Years old
* Patient is suitable according to the pre-operative evaluation standards to undergo Bariatric surgery
* Speaks Hebrew/Arabic fluently

Exclusion Criteria:

* Cognitive decline or severe psychiatric or mental illness
* Patient undergone bariatric surgery in the past
* Pregnancy or Breastfeeding
* Orthopedic disease that limits training and mobility (such as severe arthritis, injury or fractures)
* Heart disease with a risk to exercise (heart failure, severe aortic stenosis, uncontrolled arrhythmia, and acute coronary syndrome)
* Moderate /severe lung disease or COPD with FEV1 / FVC \<70% on a pulmonary function test
Tissue Oxygenation During Heart Surgery

The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG. In addition, the investigators would like to compare the results of two different monitors of brain tissue oxygenation with each other, and assess the correlation between brain tissue oxygenation and oxygenation measurements in renal and muscular tissue, as well as with conventional hemodynamic and metabolic variables, such as central venous oxygen saturation (ScvO2). Finally, the investigators aim to determine if duration and extent of cerebral oxygen desaturation predict outcome variables such as postoperative cognitive performance.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years
* Informed patient consent
* Coronary artery disease suitable for both on-pump and off-pump CABG surgery.

Exclusion Criteria:

* History of head trauma or stroke causing significant active neurologic disease
* History of neurosurgery
* Severe or symptomatic carotid artery disease
* Requirement for valve surgery in addition to CABG
* Pre-existing acute or chronic renal dysfunction
* Urgent or emergency surgery
* Difficulty with cognitive testing: impaired hearing or eyesight, poor Dutch language comprehension, disability impairing the usage of the hand or arm.
A Pilot Study Evaluating Oral Triamcinalone in Patients With Androgen Independent Prostate Cancer

The primary purpose of this study is to evaluate the ability of oral triamcinalone given twice a day to patients with androgen independent prostate cancer to produce a sustained biochemical response. Secondary goals are to describe the safety and tolerability at this dose and schedule, to determine the time to sustained biochemical response, to determine the duration of biochemical response, to determine the time to disease progression.


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age and older
* Histologically documented adenocarcinoma of prostate
* Currently receiving LHRH agonists with castrate levels of testosterone or who have had an orchiectomy
* Must have had a rise in PSA despite anti androgen withdrawal
* Exhibit 2 consecutive rise in PSA after the last hormonal manipulation
* Minimum PSA of greater than 5 KPS greater than 80%
* Normal cortisol level at entry
* Life expectancy greater than 6 months
* Provide written consent pursuant to regulatory requirements prior to initiation of study procedure

Exclusion criteria:

* Younger than 18 years
* Patients without prostate cancer
Addition of the Interferential Current to the Pilates Method in the Treatment of Chronic Nonspecific Low Back Pain

This study aims to evaluate the effectiveness of the addition of the interferential current to Pilates method exercises in the treatment of 148 patients with chronic nonspecific low back pain.


Eligibility Criteria:
Inclusion Criteria:

* Sedentary patients with chronic nonspecific low back pain longer than 12 weeks
* Pain greater than three points in Pain Numerical Rating Scale

Exclusion Criteria:

* Contra indications to physical exercise
* Serious spinal pathologies (e.g. tumors, fractures and inflammatory diseases)
* Nerve root compromise
* Pregnancy
* Infection and/or skin lesions at the site of the application of the interferential current
* Cancer
* Cardiac pacemaker
* Changes in sensitivity or allergy in the region of electrode placement
* Previous surgery on spine or physical therapy for chronic nonspecific low back pain in the last six months
* Previous experience with the Pilates method
Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients
* Age between 18 and 50 years
* Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

* Inadequate English language comprehension
* Major drug abuse problem
Mantra Meditation in Subjects That Have Chronically Impaired Attention After Stroke

There is an evidence gap on whether meditation may improve behaviorally measured attention after stroke, but preliminary research is promising. This study is the first-ever investigation of whether mantra meditation may improve chronic, severe impairment in attention after stroke.

The study is non-concurrent, multiple-baseline, across-subjects, single-case research design (SCRD). The central hypothesis is that mantra meditation (independent variable) will be associated with improvement on 1 or more tests of behaviorally measured sustained attention (dependent variable). The mantra in this study is the syllable "um" and is not assigned any spiritual, religious, or affective meaning. The mantra is repeated aloud together by the subject and the PI for a duration of 30 minutes in each session. This procedure constitutes meditation for the purposes of this study. There are 9 session of meditation (3 times per week for 3 weeks). Attention is measured in each of these sessions as well as in 3 separate testing sessions that precede the intervention period.

Eligibility Criteria:
Inclusion Criteria.

1. Adults between the ages of 18 and 70
2. Chronic, non-lacunar, right-hemisphere stroke (i.e., sustained at \>12 months prior to date of clinical screen)
3. Severely impaired attention defined as 5 or more errors of commission on the SARTfixed
4. Intact consent capacity with no evidence of dementia, defined as a score of 100% correct answer rate on University of California, San Diego Brief Assessment of Capacity to Consent (UBACC).
5. Right-handed dominance as well as sufficient movement and vision function for testing (use of computer mouse, keyboard, and monitor)
6. English language fluency and reading comprehension at least at 6th grade level

Exclusion Criteria.

1. Depression defined as a score of \>10 on Beck Depression Inventory, Short Form (BDI-SF)
2. Current or significant history of substance abuse
3. In the 3 months preceding enrollment, change in medications that impact neuroplasticity
4. Current participation in any other research study, cognitive rehabilitation, meditation, or mental training program, including commercial brain-training programs
5. Neurological disorder other than stroke (e.g., Parkinson's disorder; multiple sclerosis; traumatic brain injury)
6. Spatial attention deficit (unilateral neglect) defined as a score of 51 or fewer cancellations on the Star Cancellation Test.
7. According to the clinical judgement of the PI or her authorized designee, any other functional impairment which would significantly deter comprehension and/or execution of the requirements of the trial, such as aphasia, hearing deficit, or mobility deficit restricting navigation to, from, and within the research site. Subjects must be able to provide their own transportation to and from the study site.
8. Uncontrolled or severe mental or cognitive disorder with low psychosocial functioning, such as untreated schizophrenia, bipolar disorder, or autism
The Use of Resting State, fMRI and DTI in the Identification of Chronic Pain Conditions

Resting state fMRI scans of chronic pain sufferers will be compared to those of healthy normals and may be sufficiently different to allow a high level of classification accuracy of whether subjects have chronic pain. In addition, investigators will utilize DTI and a brief activation state using pain rumination to assess whether investigators can reliably find differences between chronic pain sufferers and healthy normals.

Resting state fMRI scans of chronic pain sufferers may be sufficiently different from scans of normal subjects to allow a high level of classification accuracy of whether subjects have chronic pain. In addition, investigators will utilize DTI and a brief activation state using pain rumination to assess whether investigators can reliably find differences between chronic pain sufferers and healthy normals. The analysis will use pattern recognition methods in a leave N out cross validation design. The success of the classifications will be the mean of all the validation runs.

Eligibility Criteria:
Inclusion Criteria:

Daily Pain lasting for more than 6 months. Ages eligible for study are between 20 and 70 years.

Exclusion Criteria:

Adults unable to consent Children, teenagers Pregnant women Prisoners Subjects who do not know English MRI exclusion criteria