cyrilzakka/clinical-trials huggingface dataset:
Technique Using Trachway to Safely Navigate Endotracheal Tube Through Nasal Cavity

To investigate the double curve endotracheal tube safely navigate through nasal cavity under guidance of a video-stylet.

we enrolled consecutive patients undergoing oxo-maxillofacial surgery by using video-stylet to establish airway and realize the tube angle changes while advancement, however, patients who did not inform or refuse to enroll into the study still use the video-stylet establish airway. the technique to use videostylet-tube assembly to establish airway is a commonly clinical practice in our hospital.

In general, the endotracheal tube goes through nasal cavity blindly either assist with traditional laryngoscope or video-laryngoscope. Tube advances through selected nasal cavity by using a video-stylet is able to prevent from damages of the abnormal turbinates and tissue mucosa. In addition, we are able to record the stylet angle into nostril, shift axis angle in nasal cavity to prevent orifice and side hole from damaging tissues while tube-stylet assembly advancement, and the angle ranges from initiate intubation to tube advanced into trachea.

the selected nostril is determined by Otolaryngologist who is not aware of the study.

Eligibility Criteria:
Inclusion Criteria:

* patients undergo regular operation of oro-maxillofacial surgery

Exclusion Criteria:

* easily nasal bleeding, mouth limited (opening mouth \< 3cm), hypertension, diabetes, chronic sinusitis with operative history, patients unwilling to be included.
Effect of Superficial Cervical Plexus Block on Post Operative Nausea and Vomiting in Tympanomastoid Operations

post operative nausea and vomiting are very common after tympanomastoid operations, in this study we are investigating the effect of superficial cervical plexus block on the incidence and severity of those post operative complications.

various treatments and regimens have been tried to overcome the problem of postoperative nausea and vomiting after tympanomastoid surgery. superficial cervical plexus block seems so promising in this regards as it may reduce the incidence and severity of PONV through 3 mechanisms: primarily through blocking vagal afferents to the middle ear which mediate the vomiting reflex, and secondarily through decreasing pain which aggravates PONV, and finally through decreasing intra and post operative opioid consumption due to adequate analgesia which in turn avoids opioids side effects including PONV.

the study group will receive superficial cervical plexus block while the control will receive the same block while given placebo instead of (lidocain/bupivacaine mixture) incidence and severity of PONV will be recoded according to a scale to find the difference between both groups.

Eligibility Criteria:
Inclusion Criteria:

* Patients belonging to American Society of Anesthesiologists physical status I-II.
* operation time less than 4 hours.

Exclusion Criteria:

* • American Society of Anesthesiology (ASA) physical status ≥ III.

  * Uncooperative or mentally retarded patients.
  * Known Allergy or hypersensitivity to lidocaine or bupivacaine.
  * Patients known to have gastritis or Gastro-oesophageal reflux disease (GERD).
  * History of PONV or motion sickness.
  * Operation duration (short less than 30 minutes or prolonged more than 240 min).
  * Patients with chronic renal disease (serum creatinine level ≥2.0mg/dl) or on renal replacement therapy (dialysis).
  * Patients with chronic cholecystitis (history of recurrent or persistent vomiting)
  * Skin inflammation and cellulitis.
Allogeneic Transplantation Using Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) for Older Patients With Hematologic Malignancies

To measure how frequently and to what degree a complication of transplant cell acute graft versus host disease (GvHD) occurs.

This study evaluated whether TLI-ATG conditioning followed by allogeneic hematpoietic cell transplant (HCT), which has provided excellent overall survival for patients with relapsed lymphoma after failed autologous HCT, provides a similar benefit in the setting of elderly patients with hematologic malignancies.

Eligibility Criteria:
INCLUSION CRITERIA:

* Any patient with one of the following hematolymphoid malignancies or syndromes in whom allogeneic hematopoietic stem cell transplant (HST) is warranted. Specific disease categories include:

  * Indolent advanced stage non-Hodgkin lymphomas
  * Mantle cell lymphoma
  * Chronic lymphocytic leukemia
  * Hodgkin disease (Hodgkin's lymphoma)
  * Acute leukemias in complete remission
  * Aplastic anemia
  * Paroxysmal nocturnal hemoglobinuria
  * Myelodysplastic or myeloproliferative syndromes.
  * Other selected malignancies/disorders may also be considered but must be approved by the transplant team and the Principal Investigator.
* Age \> 50 years, or if \< 50 years of age, considered to be at high risk for regimen-related toxicity associated with conventional myeloablative transplants due to pre-existing medical conditions or prior therapy.
* A fully human leukocyte antigen (HLA)-identical sibling or matched unrelated donor is available. Potential participants with one antigen mismatched donors can be considered but only after discussion with the transplant team and the Principal Investigator.
* Participant must be competent to give consent.

EXCLUSION CRITERIA:

* Progressive hematolymphoid malignancies despite conventional therapies, or acute leukemias not in complete remission.
* Uncontrolled central nervous system (CNS) involvement with disease
* Fertile men or women unwilling to use contraceptive techniques during and for 12 months following treatment
* Pregnant
* Cardiac ejection fraction \< 30%
* Uncontrolled cardiac failure
* Pulmonary diffusing capacity (DLCO) \< 40% predicted
* Elevation of bilirubin to \> 3 mg/dL
* Transaminases \> 4 x the upper limit of normal
* Creatinine clearance \< 50 cc/min (24-hour urine collection)
* Karnofsky performance score \< 60%
* Poorly controlled hypertension on multiple antihypertensives
* Documented fungal disease that is progressive despite treatment
* HIV-positive. Other viral infections, ie, Hepatitis B- and C- positive, evaluated on a case-by-case basis
* Psychiatric disorders or psychosocial problems which in the opinion of the primary physician or Principal Investigator would place the patient at unacceptable risk from this regimen.
Clinical Evaluation of FLACS With Combination of LenSx® and Centurion®

The purpose of this study is to evaluate cumulative dissipated energy (CDE), endothelial cell loss, and average torsional amplitude with combination of LenSx® and Centurion® compared to conventional cataract surgery.

Subjects will attend 7 scheduled visits: 1 pre-operative, 1 operative, and 5 post-operative.

Eligibility Criteria:
Inclusion Criteria:

* Cataracts (Grade 2-4 of Emery-Little Classification) with planned cataract removal by phacoemulsification in both eyes;
* Able to comprehend and willing to sign informed consent and complete all required postoperative follow-up procedures;
* Calculated lens power within the available range;
* Other protocol-specified inclusion criteria may apply.

Exclusion Criteria:

* Any pathology that could reduce visual potential;
* Hypotony or the presence of a corneal implant;
* Residual, recurrent, active ocular or eyelid disease;
* Poorly dilating pupil;
* Any contraindication to cataract;
* Eyes with two different levels of cataract grade;
* Pregnant, or planned pregnancy during the study;
* Expected to require an ocular surgical treatment at any time during the study;
* Other protocol-specified exclusion criteria may apply.
Cohort of Mexican Children With Diabetes Mellitus (CMC-DM)

The aim of this study is the identification of complications in diabetes mellitus pediatric patients and to compare the clinical, anthropometric, and biochemical characteristics between children in the different types of diabetes mellitus.

Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin resistance in target tissues. This study identify the influence of pathogenic factors on the evolution of diabetes mellitus and in the presence of chronic complications.

Eligibility Criteria:
Inclusion Criteria:

* Patients with confirmed diagnosis of diabetes mellitus

Exclusion Criteria:

-
Airway Management With Simulated Microgravity Using a Submerged Model

Trained anesthesiologist- or emergency physician-divers will perform an airway management in simulated microgravity on a submerged model.

Trained anesthesiologist- or emergency physician-divers participate in the study. Simulated microgravity during spaceflight is obtained by using a submerged model. Full-torso manikins is going to be used for performing airway management. Each diver attempted airway management with each device (laryngeal mask, laryngeal tube, orotracheal intubation with video-assisted laryngoscope. The time for airway protection will be measured as well as the success rate.

Eligibility Criteria:
Inclusion Criteria:

* Anaesthesiologist with diver licence or Emergency physician with diver license

Exclusion Criteria:

* All other
Exploration of Mechanisms for Weaning Failure

This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT).

The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .

This observational study mainly include participants who had invasive mechanical ventilation for ≥48 h and are assessed to be ready for the SBT trial.The SBT approach is based on the low-level pressure support mode.

Prior to the SBT trial, baseline demographic and physiologic data of the participants will be collected, and the participants will be divided into two groups based on the results of the SBT trial: successful and unsuccessful, and the physiologic changes during the SBT trial will be compared between the two groups, respectively.

Eligibility Criteria:
Inclusion Criteria:

* Invasive mechanical ventilation for at least 48 hours

Exclusion Criteria:

* neuromuscular disease；Postoperative patients or patients with traumatic brain injury
Clinical Study on Veloderm for the Treatment of Split-thickness Skin Graft Donor Sites

This study is a multi-center, randomized, open and paralleled positive control study for evaluating the safety and efficacy of Veloderm in treatment of split-thickness skin graft donor sites. The result implies that Veloerm can do it better than Vaseline gauze in accelerating and promoting wound healing of skin graft donor sites. The present study have indicated that high permeability of Veloderm dressing to oxygen and water vapor.

The rational oxygen permeability of Veloderm dressing also provides a good environment for wound healing. Therefore, it can be as a temporary skin substitute in the case of missing epidermis to play a role, in order to provide an ideal environment for wound epithelialization. As regards safety, 1 adverse reaction occured in test group. It shows effusion under the dressing mild inflammatory infiltration on the wound edge. After the dressing was changed and the effusion was drained, the patient was relieved. As Veloderm dressing itself has no direct anti-inflammatory effects, clinical application as appropriate can plus other anti-infective drugs in accordance with patient conditions. In conclusion, Veloderm is a safe and effective dressing to accelerate the healing of donor sites in burn and plastic surgery. Veloderm can be used as a temporary skin substitute in case of damage of skin or loss of superficial epidermal (such as burns, wounds, abrasions, ulcers, sores and auto-graft donor areas).

Eligibility Criteria:
Inclusion Criteria:

* Aged 18-65 years
* Male or female patients
* Skin lesions or losses by burns, plastic surgery, sores, abrasions, donor graft areas and after debridement of chronic wounds
* The area of skin loss or burn surface is less than 50% of total area of body surface
* Subject undergoing first skin harvest 0.25-0.35mm and donor site having a surface area\>100cm2
* Subject who is willing to participate in the trial and to sign the informed consent form.

Exclusion Criteria:

* Area of skin loss or burn surface is larger than 50% of total area of body surface
* Electrical burns or chemical burns
* Burns complicated by combined injury
* Test wound needs drugs that may affect wound healing
* Subject who has a known hypersensitivity to hemycellulose
* Contraindication to the use of semi occlusive dressing
* Pregnant or lactating subject
* Any severe disease which in the Investigator's judgement might interfere with study evaluations or threaten patient's safety
* Subject who has chronic renal disease or renal inadequacy, or serum creatinine is more than twice the upper limit of normal
* Subject who has a definite liver disease, TBil or AST, ALT is more than twice the upper limit of normal
* Subject with active hemorrhoea or shock or visceral injury; Subject who has participated in this clinical study or other clinical studies within 3 months
* Subject with mental impairment limiting the ability to comply with study requirements; Subject undergone chronic treatment with immunosuppressants, antineoplastic drugs and corticosteroids for a long time
* Subject who has not signed the informed consent form.
Long-term Study in Early Loaded Hydrophilic Surface Implants

Objective: To assess the clinical outcomes and patient satisfaction of early loaded implants with a hydrophilic, moderately rough surface for partially edentulous patients after a follow-up of 8.5 to 9.5 years.

Materials and methods: A prospective observational single-centre study involving 15 patients with single, delayed placement and early loaded implants in the posterior area was performed. Clinical and radiographical parameters, including biological and technical complications and patient satisfaction, were assessed.


Eligibility Criteria:
Inclusion Criteria:

* Individuals between the ages of 18 and 75 years (inclusive)
* Partially edentulous patients with missing teeth in the posterior mandible (positions 34-37 and 44-47) and a healed site at least four weeks after tooth extraction
* Patients requiring a single dental implant
* Patients with physical status 1 or 2 according to the American Society of Anesthesiologists Classification System
* Inadequate native bone quality and quantity to place implants with a diameter of ≥4.0 mm
* Removable prosthesis or complete dentures in the antagonizing dentition
* Written informed consent

Exclusion Criteria:

* Patients with compromised general health contraindicating surgical intervention
* Presence of conditions requiring chronic routine prophylactic or prolonged use of antibiotics
* Heavy smokers (exceeding ten cigarettes/day or equivalent) and chewing tobacco users
* Pregnancy or childbearing potential with a positive urine pregnancy test
* Insufficient oral hygiene, untreated periodontitis (any residual pockets \>4 mm), or persistent intra-oral infection
* Mucosal diseases such as erosive lichen planus
* Patients with severe bruxism or clenching habits
* Unwillingness to participate in the study
Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy

It is not unusual for several children operated for severe adenoid hyperthrophy causing breathing problems to have otitis media with effusion simultaneously. It is unknown whether adenoidectomy, myringotomy and tubes insertion is superior to adenoidectomy and myringotomy alone in terms of otitis media related quality of life and recurrence of otitis media several months after the operation. For this purpose a randomized trial is conducted including children operated for adenoid hyperthrophy and whose otitis media with effusion had caused minimal or no symptoms so far


Eligibility Criteria:
Inclusion Criteria:

* children operated for their adenoid hyperthrophy with an adenoid size of 3 (measured in a scale of 1-3 intraoperatively or from lateral neck x-ray) and otitis media with effusion causing an average air-bone gap of greater than 20db. Children should be otherwise healthy with an ASA score of I and between 3-12 years old of age

Exclusion Criteria:

* other health problems especially related with the condition eg cleft palate
Efficacy of a Capsular Tension Ring in Preventing Anterior Capsule Shrinkage After Cataract Surgery in Exfoliation Syndrome

The purpose of this study is to examine the efficacy of a capsular tension ring (CTR) in preventing anterior capsule shrinkage after cataract surgery in exfoliation syndrome (XFS) with no zonular weakness. The eyes with XFS undergo phacoemulsification and aspiration (PEA) with an intraocular lens (IOL) implantation. All operations are performed by a single surgeon. No eyes with either ectopia lentis or phacodonesis are included. There are three groups; CTR is not used in group A, CTR is simply implanted in group B, and CTR is implanted and closed by tying both eyelets in group C. The areas of continuous curvilinear capsulorhexis (CCC) are calculated, and both the time-course change and the comparison among the 3 groups are tested.


Eligibility Criteria:
Inclusion Criteria:

* Eyes with exfoliation syndrome are included.

Exclusion Criteria:

* Eyes with either ectopia lentis or phacodonesis are excluded.
Effects of Hydrotherapy on Physical Function and Quality of Life of Women With Fibromyalgia

Fibromyalgia Syndrome (FS) is one condition that most affects functional performance, especially in women, due to alterations in the entire musculoskeletal system. Given that, Physical Therapy (PT) studies the human movement and its dysfunctions, and that FS, because of its complex chronic characteristic, impairs the affected individual's activities causing movement disorders, a PT professional must be part of the multidisciplinary team involved in the FS treatment. Nonetheless, as explained in the present proposal, several aspects still need clarification related to the PT role in this syndrome. Particularly, studies that analyze the biomechanical, sensorial and cardiorespiratory adaptations in individuals who undergo PT intervention still lack; those studies would contribute with scientific evidence to the clinical practice. According to recent systematic reviews, one of the most used therapies with positive effects on FS subjects is the hydrotherapy, which combines exercises and the water relaxing effects. Other alternative treatments have also been searched, in an attempt to decrease the painful picture presented, as the FS etiology and pathophysiology are not well known. The aim of this study is to evaluate the efficacy of different physical therapy resources in the FS, in two subprojects. The first will verify if hydrotherapy is effective in modifying movement variables (scapular kinematics and electromyography) and autonomic modulation. Other variables, such as pain level and quality of life in women with FS, will also be analyzed. The second study will evaluate the efficacy of the Shiatsu massage on pain, sleep quality, balance and quality of life of subjects with FS.

Subjects were invited to take part in several assessments before starting the actual Hydrotherapy Treatment. These assessments were:

1. Three-dimensional scapular evaluation
2. Questionnaires (FIQ, SF-36, Beck Depression Inventory, Beck Anxiety Inventory, Pittsburgh Quality of Sleep Index)
3. Pain (pressure pain threshold and trigger points) Subjects were evaluated 3 times one month before starting treatment, one time in the middle of treatment and after treatment completion.

Treatment lasted 16 weeks and consisted of 2 weekly 45' hydrotherapy sessions.

Eligibility Criteria:
Inclusion Criteria:

* to have a clinical fibromyalgia diagnosis according to the 1990 ACR criteria
* to be aged from 30 to 60 years old.

Exclusion Criteria:

* Body Mass index \>28kg/m²
* Cognitive deficits that prevented patients to understand the evaluation procedures
* Uncontrolled systemic illnesses (e.g. diabetes mellitus and systemic arterial hypertension)
* Neurological and musculoskeletal conditions that could have directly interfered in the evaluations, as paresis, important sensitive alterations, advanced joint diseases (e.g. arthroplasties or osteoarthritis)
* Infections
* Urinary incontinence
* Pregnancy
Evaluation of Prognosis Factors of Neurological Evolution in Cardiac Arrest

With the repercussion of 55 cases eachyear for 100 000 inhabitants in France, cardio respiratory arrest is a public health issue.

The goal of this study is to evaluate the pupillary light reflex measured by the dimension of the pupil (diameter) as a prognosis factor neurological evolution in post cardiac arrest. By participating to this study, the patient get the same tratments and exams than in a usual managing cares.

In addition of these events, the pupillary light reflex is studied as soon as the patient is accepted in the department, and then on the second day.

Currently, the evaluation of the neurological becoming rely on a multimodal clinical and paraclinical approach.

The study of the pupillary light reflex measured by the diameter of the pupil could be a prognosis factor of neurological evolution for patients in post cardiac arrest, so a reliable and available prognosis marker in patient care.

The goal of this study is to evaluate the pupillary light reflex (RPM), measured by the diameter of the pupil as a prognosis factor of neurological evaluation of admitted patients after a cardiac arrest.

Principal criteria of judgement is the percentage of the pupillary light reflex variation measured with Neurolight®, compared between two groups.


Eligibility Criteria:
Inclusion Criteria:

* Both gender
* Entry in resuscitation after a cardiac arrest intra or extra-hospital
* Resumption of a spontaneous cardiac activity
* Affiliation to a social security system

Exclusion Criteria:

* Refusal from patient or his family
* Age under 18 years
* Pregnant women
* Previous neurological damages
* Persons deprived of liberty by judicial or administrative decision