cyrilzakka/clinical-trials huggingface dataset:
Computerized Cognitive Training Program for Older Persons With Mild Dementia

Little is known about the effects of computerized cognitive training programs on mild dementia patients' health. The purpose of this study was to examine the effects of a community-based computerized cognitive training program.

Little is known about the effects of computerized cognitive training programs on mild dementia patients' health. The purpose of this study was to examine the effects of a community-based computerized cognitive training program.However, most of these studies were not randomized controlled trial and the samples of these studies were mostly healthy older persons, patients with brain injuries, or with moderate and severe dementia. A lack of studies for effects of these programs on patients with mild dementia using randomized controlled trials was found. The purpose of this study was to examine the effects of a community-based computerized cognitive training program.

Eligibility Criteria:
Patients' Inclusion Criteria:

* Aged 65 or older,
* Being diagnosed as having mild dementia by a neurologist, and
* Being able to communicate in Mandarin or Taiwanese.

Patients' Exclusion Criteria:

* Vision or hearing impairment.

Caregivers' (proxy) Inclusion Criteria:

* Living with the dementia patient,
* The family member spending the most time on the patient's care, and
* \>20 years old.

Caregivers' (proxy) Exclusion Criteria:

* Terminally ill
Effect of Menstrual Cycle on Central Nervous System (CNS) Processing of Gut Stimuli in Irritable Bowel Syndrome (IBS) and Control

The hypothesis of the study is that women perceive intestinal stimulation (rectal balloon distention) differently in different phases of the menstrual cycle, i.e there is an effect of hormones on the sensory pathway, and that this difference is reflected in the Central Nervous System processing of this signal. We also hypothesize that there is a difference in perception between control subjects and subjects with the irritable bowel syndrome.

There is discrepancy in the literature concerning the effect of the menstrual cycle on bowel function and pain syndromes such at irritable bowel syndrome. In addition, recent studies indicate a difference in the CNS processing of rectal stimulation in normal subjects and patients with IBS. This study will determine the differences in the perception of rectal balloon distention in the follicular and luteal phases of the menstrual cycle, in control subjects with no bowel symptoms and volunteers with IBS, and will compare the CNS processing of this signal using functional MRI , again in the two phases of the menstrual cycle.

Comparisons: between control subjects without GI symptoms and those with irritable bowel syndrome.

Eligibility Criteria:
Inclusion Criteria:

* controls - normal bowel function
* Irritable bowel syndrome - Rome II criteria
* Normal menstrual cycle

Exclusion Criteria:

* irregular menses
* pregnancy
* use of psychotropic medication
* claustrophobia
* metal implants
* metal in eyes
Point-Of-Care TBI Detection System For Head Injured Patients In The Emergency Department

A prospective, non-randomized trial for the extension and replication of the development database of brain electrical activity recordings and clinical information collected from patients who present to the ED following closed head injury.

The objective of this study is to test the clinical utility of the BrainScope technology for the acute identification of traumatic structural brain injury in the TBI population, following closed head injury. The data generated will serve to validate and/or refine the current algorithms to detect acute, traumatic, structural brain injury.

Eligibility Criteria:
Inclusion Criteria:

* Subjects who are admitted to the ED and are suspected of a traumatic, closed head injury within 24 hours. The patient will have a GCS 12-15 upon arrival to the ED even if GCS was lower prior to arrival to the ED (e.g., at the time of injury).

Exclusion Criteria:

* Subjects will be excluded who have forehead, scalp, or skull abnormalities or other conditions that would prevent correct application of the electrode headset on the skin.
* In addition,

  * subjects with dementia,
  * Parkinson's Disease,
  * multiple sclerosis,
  * seizure disorder,
  * brain tumors,
  * history of brain surgery,
  * psychiatric disorder being managed by a psychiatric healthcare professional/provider,
  * substance dependence,
  * history of TIA or stroke within the last year,
  * currently receiving dialysis or in end-stage renal disease,
  * active fever defined as greater than 100 degrees F or 37.7 degrees C,
  * current condition is "critical" in the opinion of the investigator,
  * subject is suffering from an open head injury,
  * subject requires advanced airway management (i.e. mechanical ventilation), currently receiving procedural sedation medications.
* Subjects below the age of 18 years, and prisoners will not be eligible for study.
Living Donor Liver Transplantation to Patients With Portal Vein Thrombosis

Data of demographic, clinical, laboratory and imaging studies of living donor liver transplantation (LDLT) recipients from two transplant centers were collected. Survival and morbidity rates between patients with and without portal vein thrombosis (PVT) were compared. Risk factors of mortality in the setting of PVT were identified. Intraoperative portal flow measurements were compared before and after portal flow restoration.

LDLTs performed in two experienced centers (Ankara University Ibn-i Sina Hospital and Ankara Güven Hospital) between January 2013 and February 2020 were evaluated and included in the cohort study. Deceased donor liver transplants and pediatric transplants (deceased or living) were excluded from the study.

Data relating to this study including patient history, preoperative laboratory and imaging test results, reports of surgical procedures or interventions, intraoperative anesthesia records, post-operative laboratory trends, and postoperative complications were extracted from the computer-based data management system and prospectively maintained in transplant databases in both centers. Recipients of LDLT were divided in two groups according to the presence or absence of PVT.

Portal flow measurements were recorded with VeriQ (Medistim ASA, Oslo, Norway) Doppler flowmeter device in one of the centers later in the study period.

The follow-up and recordings of the patients were maintained in the outpatient clinics of the two centers.

The most serious complication experienced by each patient was recorded according to the Clavien-Dindo classification Primary outcome of the current study was the survival rates of patients with and without PVT Secondary outcomes of the study included morbidity in patients with and without PVT after LDLT, risk factors of mortality after LDLT to patients with PVT and comparison of intraoperative portal flow measurements between patients with and without PVT

Eligibility Criteria:
Inclusion Criteria:

* Patients underwent liver transplantation

Exclusion Criteria:

* Pediatric liver transplants
* Deceased donor liver transplants
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults

The goal of the study is to determine whether there are age-, diet- and genetically-related differences in the perception of sweeteners, both nutritive and non-nutritive.

This is an observational 3-day study of children between the ages of 7 and 14 and their mothers. A variety of psychophysical methods determined liking for each of the sweeteners and saliva samples were obtained for genotyping of taste receptor genes. Anthropometric and dietary intake measures were also collected.

Eligibility Criteria:
Inclusion Criteria:

* Healthy

Exclusion Criteria:

* Allergies and taking medication that affected taste
Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases

One of the proposed mechanisms in CU is autoimmunity. It was shown by a positive response to autologous serum skin test (ASST)in almost half of chronic urticaria (CU) patients. IL-18 also play a role in autoimmune disorders. The investigators aim was to investigate the relationship of ASST and IL-18 in CU and respiratory allergic diseases.


Eligibility Criteria:
Inclusion Criteria:

* adult patients
* chronic urticaria patients
* stable asthma patients
* allergic rhinitis patients with sensitized to pollens
* normal controls without atopic and skin disease.

Exclusion Criteria:

* unwillingness to the study
* other dermatological problems that could affect the skin test
* use of antihistamine drugs
A Study of Aripiprazole Lauroxil or Paliperidone Palmitate for the Treatment of Schizophrenia

This study will evaluate the efficacy of initiating treatment of schizophrenia with ARISTADA INITIO plus 30 mg oral aripiprazole followed by a 2-month dose of AL.


Eligibility Criteria:
Inclusion Criteria:

* Has a diagnosis of schizophrenia
* Requires acute treatment for symptoms of schizophrenia
* Willing and able to be confined to an inpatient study unit for up to 3-4 weeks
* Has experienced at least one previous hospitalization for schizophrenia
* Has been able to achieve outpatient status for more than 3 months in the past year
* Has a body mass index (BMI) between 18.0 and 40.0 kg/m\^2
* Resides in a stable living situation when not hospitalized
* Has an identified reliable caregiver (for example, family member)
* Additional criteria may apply

Exclusion Criteria:

* Poses a current suicide risk
* Pregnant, planning to become pregnant, or breastfeeding
* Initiated first antipsychotic treatment within the past 12 months
* Has received a long-acting injectable antipsychotic in the past 3 months
* Has participated in a clinical study involving any investigational product within the past 3 months, or is currently participating in a clinical study involving an investigational product.
* A positive urine drug test for drugs of abuse
* Additional criteria may apply
Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses

Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin, as well as its protein characteristics, following the administration of a single iron dose


Eligibility Criteria:
Inclusion Criteria:

* Low iron stores (SF levels \< 30 µg/L),
* no anemia (Hb \> 120 g/L)
* no inflammation (CRP \< 5 mg/L)
* 18 to 45 years old.
* Body weight \<70 kg
* Normal body Mass Index (18.5-26.5 kg/m2)

Exclusion Criteria:

* Any chronic or acute disease
* Consumption of mineral and vitamin supplements since screening and over the study period
* Blood transfusion, blood donation or significant blood loss over the past 6 months,
* Pregnant or breastfeeding,
* Continuous/long-term use of medication during the whole studies (except for contraceptives)
* Therapeutic iron infusion over the past 6 months,
* Known hypersensitivity or allergy to iron supplements,
* Intention to become pregnant over the course of the study
Transanal Haemorrhoidal Dearterialisation Versus Stapler Haemorrhoidopexy

The aim of the present study was to compare the results of transanal haemorrhoidal dearterialisation and stapler haemorrhopidopexy in the treatment of grade III and IV haemorrhoids with a long-term follow-up.


Eligibility Criteria:
Inclusion Criteria:

* grade III and IV hemorrhoids requiring hemorrhoidectomy.

Exclusion Criteria:

* first and second degree hemorrhoids
* patients with firm and fibrotic external irreducible haemorrhoids
* thrombosed hemorrhoids; recurrent hemorrhoids after previous surgical treatment
* history of inflammatory bowel disease; history of colon, rectal or anal cancer
* inability to give informed consent
* age \< 18 years
* pregnant women.
Comparative Spectroscopic Analysis of Synovial Fluid From the Stable and Unstable Ankle

A population of patients with chronic ankle instability for whom arthroscopic ligament stabilisation was indicated.

Main objective: to use the Raman microspectroscopy technique to characterise the synovial fluid of the unstable ankle in comparison with the synovial fluid of the healthy ankle.

Single-centre, prospective, open-label study of patients undergoing ankle stabilisation surgery.

Patients will participate in the study for six months. Three arthrocentheses with synovial fluid sampling will be performed Two at D0: on the healthy ankle and the pathological ankle One at M6: on the operated ankle A follow-up visit will take place 10 days after the arthrocentesis performed at D0 and after the one performed at M6. The purpose of these visits, which are carried out systematically by the centre's doctors as part of the surgical procedures, is to check that there are no complications.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 or over who have signed their consent to participate in the study
* Patients with chronic unilateral lateral ankle instability
* Patients who have not responded to medical treatment and for whom arthroscopic stabilisation of the ankle is planned.

Exclusion Criteria:

* Any history, anomaly or symptom relating to the contralateral ankle
* Patient under court protection, guardianship or curatorship
Use of the LEVA® Pelvic Health System for Fecal Incontinence

The goal of this clinical trial is to learn about how the duration of use of The Leva Pelvic Health System® affects treatment of fecal incontinence in women. The main question it aims to answer is to test whether use of the The Leva Pelvic Health System® for 8 weeks is as good as using it for 16 weeks.

Participants will complete surveys, and use the Leva device.

This study will assess whether 8 weeks of use of the Leva Pelvic Health System (Leva) is non-inferior to 16 weeks of use for the treatment of chronic fecal incontinence (symptoms \>/= 3 months) in adults with a vagina. Participants will be instructed to complete pelvic floor muscle training using the Leva for 8 or 16 weeks.

The hypothesis is that 8 weeks of use of Leva is non-inferior to 16 weeks of use, assessed by a validated FI symptom severity survey. Surveys will be completed at 0 weeks, 16 weeks, and 24 weeks. Long-term surveys will be completed at 1 year and 2 years from enrollment.

Eligibility Criteria:
Inclusion Criteria:

* Adult, age ≥ 18years, assigned female at birth
* Fecal incontinence, defined as any uncontrolled loss of liquid or solid fecal material that occurs at least monthly over the last 3 months that is bothersome enough to desire treatment
* Able to stand to perform daily training for at least 3 minutes
* Able to speak and read English due to Leva smartphone application availability in only English at this time
* Have an email address, owns a smartphone, and can download an app

Exclusion Criteria:

* Inability to tolerate insertion of vaginal device (e.g., vaginal agenesis, vaginal stenosis, unremitting pelvic pain, within 12 weeks postpartum)
* Current diagnosis of colorectal or anal malignancy
* Diagnosis of uncontrolled inflammatory bowel disease
* Current rectovaginal fistula or cloacal defect
* Rectal prolapse (mucosal or full thickness)
* Inability to utilize smart phone technology ("app" use)
* Chronic Stool Types 6 or 7
* Fecal impaction by exam
* Stage 4 pelvic organ prolapse
* Concurrent supervised anal sphincter exercise/pelvic floor muscle training with or without biofeedback
* Presence of sacral neuromodulator
* Pelvic floor surgery (including anal sphincteroplasty) within the past 3 months
* Currently pregnant
Targeting Pregnancy-related Weight Gain to Reduce Disparities in Obesity

The purpose of this study is to find out whether a technology-base healthy lifestyle program is an acceptable and effective way for African-American mothers to improve their eating and activity during pregnancy, compared to usual obstetric care. The goal of the program is to enhance the health of African-American mothers and their babies.

Black women are in particular need for obesity prevention and treatment. The childbearing period represents a critical life stage of heightened vulnerability for new or persistent obesity, especially among Black women, who retain 2-3 times more weight after pregnancy than White women. Pregnancy weight gain is the strongest identified risk factor for retaining a substantial amount of weight after pregnancy, yet few published interventions have been effective in reducing excessive weight gain in pregnancy, particularly among low-income Black mothers.

The proposed research aims to meets the needs of low-income, Black mothers by developing a novel pregnancy intervention that 1) focuses solely on Black women, 2) incorporates Black mothers' information needs, values, and social context, and 3) uses technology to facilitate participant engagement.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant African-American women at least 18 years of age
* BMI at recruitment between 25.0-44.9 kg/m2
* Singleton pregnancy
* Gestational age of ≤ 20 weeks as determined by last menstrual period
* Plan to carry the pregnancy to term and keep the baby
* Own a cell phone with a text messaging plan
* Member of Facebook social networking site
* Able to participate in physical activity
* Participants must be willing to comply with all study-related procedures

Exclusion Criteria:

* 1. BMI ≤ 24.9 or ≥ 45.0
* Uncontrolled hypertension (systolic blood pressure \> 160 or diastolic blood pressure \> 95 mmHg). Participants with controlled hypertension on medication for at least three months are allowable.
* Known atherosclerotic cardiovascular disease
* Known congestive heart failure
* Known diabetes mellitus (type 1 or type 2)
* Uncontrolled thyroid disease. Participants with controlled thyroid disease on medication for at least three months are allowable.
* Known cancer
* Any major active rheumatologic, pulmonary, hepatic, dermatologic disease or inflammatory condition requiring steroids or immune modulating medications
* History of testing HIV positive
* Current smoker or tobacco user
* Current or recent history (past 6 months) of drug or alcohol abuse or dependence
* Participation in any weight control or investigational drug study within 6 weeks of screening
* Serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety for successful participation in the study
* Gastrointestinal Disorders (gallbladder disease, Crohn's disease, etc)
* Previous weight loss surgery
* History of bulimia or anorexia
Lung Ultrasound in Comparison With C.T in Covid-19

investigate the diagnostic ability of thoracic ultrasound in suspicious COVID-19 infection and/or COVID-19 pneumonia. Also, to compare its findings to CT and follow up these findings.

ultrasound and C.T will be assessed in acute presentation of Covid 19 patients and then those patients will be reassessed again after 1 month by lung ultrasound and C.T and if ultrasound will show the same efficacy of diagnosis or not

Eligibility Criteria:
Inclusion Criteria:

* all cases of covid 19 patients

Exclusion Criteria:

* all other causes of consolidation ,ground glass fibrosis or collapse findings of C.T and ultrasound
TRACE: Tirapazamine-Radiation And Cisplatin Evaluation

The trial will compare the efficacy and safety of concomitant chemoradiation with tirapazamine, cisplatin and radiation versus cisplatin and radiation.


Eligibility Criteria:
Inclusion Criteria:

* Previously untreated squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx.
* Stage III or IV disease (excluding T1N1, and T2N1 and metastatic disease).
* Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2.
* Absolute neutrophil count at least 1.5 X 10\^9/L, platelet count at least 100 X 10\^9/L, and hemoglobin \> 9g/dL.
* Serum bilirubin \< 1.25 times upper limit of normal (ULN) and aspartate aminotransferase (AST)/alanine transaminase (ALT) \< 2.5 times ULN.
* Calculated creatinine clearance (Cockcroft-Gault) \> 55 mL/min.

Exclusion Criteria:

* Metastatic Disease
* Primary cancers of the nasal and paranasal cavities and of the nasopharynx
* Significant intercurrent illness that will interfere with the Chemotherapy or Radiation Therapy during the trial
* Symptomatic peripheral neuropathy \> grade 2
* Clinically significant hearing impairment
* Significant cardiac disease
Analgesic Efficacy of Lidocaine Plus Bupivacaine Versus Bupivacaine Alone Caudally

Optimal analgesia following ambulatory surgery is an important matter for patient satisfaction and it reduces unnecessary hospital admissions. This study investigated whether caudal block with different combinations of local anesthetics can alter postoperative pain scores and additional rescue analgesic use. The investigators also aim to determine the side effects of these technique such as nausea, vomiting, bradycardia, hypotension, respiratory depression, length of hospital stay, first micturition or mobilization times, surgical and anesthetic complications.

Circumcision, which is performed on an outpatient basis is commonly a short durational operation in boys. Postoperative pain and agitation are the most common complaints in children with circumcision. The most important factor affecting the length of hospital stay is to provide an effective analgesia. Various methods are being used to manage postoperative pain such as caudal block, penile block, topical analgesia or intra-venous (iv) analgesics. Caudal block is applicable widely in pediatric day case surgery, providing excellent postoperative analgesia and attenuation of the stress response in children. Opioids can cause several side effects such as respiratory depression, suppression of bowel movements, nausea, vomiting, itching, addiction. Opioid drugs are not recommended in children as well. Lower abdominal surgeries affect dermatomes T10-L1 and blocking these nerve roots provides effective postoperative analgesia. Neuraxial blocks such as epidural and caudal blocks is considered the gold standard regional technique for pain management after lower abdominal surgery, blocking both somatic and visceral pain. Recent studies suggest that lidocaine and bupivacaine can be used in combination or a sole agent when performing regional anesthesia in children. But it remains unknown whether these combinations are useful or simply reflect underlying status. There is no report comparing the effects of bupivacaine alone and in combination with lidocaine at performing caudal epidural block in children. The investigators thus tested the primary hypothesis that combining the two different local anesthetics has a synergistic analgesic effect and can accelerate the onset time and decrease the need for additional analgesic doses. Secondarily, the investigators tested the hypothesis that providing intra-operative and postoperative analgesia reduces the risk of hemodynamic deteriorations, length of hospital stay, first micturition and mobilization times, surgical and anesthetic complications.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists (ASA) class 1.
* Patient underwent elective circumcision operation under general anesthesia and caudal analgesia.

Exclusion Criteria:

* Procedures simultaneously underwent another operation unrelated to circumcision.
* Patients who had unsuccessful caudal block.