cyrilzakka/clinical-trials huggingface dataset:
Evaluation of a School-Based Training Program for Suicide Prevention

This study will determine whether a training program designed to help school staff members identify adolescents at risk for suicide will increase the number of students who are referred to mental health services.

The rate of suicide among adolescents has significantly increased in recent years. Psychiatric disorders are often associated with increased suicide risk; therefore, the ability to identify adolescents with signs of depression and other psychiatric conditions is clear. This study will determine the effectiveness of a suicide prevention training program called Question, Persuade, Refer (QPR) in increasing the number of potentially suicidal adolescents who are referred to mental health services. The training is designed to help school staff recognize signs that a student may be suicidal, provide tips on how to question students about any suicidal thoughts they may have, and provide techniques to persuade students to seek suicide prevention help.

School staff will be randomly assigned to either receive QPR training for 2 years starting immediately or be placed on a waiting list for later training. The rates of referral to the school district's prevention/intervention centers will be used to assess the effectiveness of QPR training. In addition, the impact of QPR training on school staff members' knowledge and attitudes about intervening with at-risk students will be assessed through surveys at four time points over the 2-year study duration with a randomly selected portion of staff in the 32 participating schools. Surveys completed by randomly selected 8th and 10th grade students will also be used to determine whether the intervention is effective in reducing suicidal thoughts or attempts.

Study hypothesis: More students in schools that have Question, Persuade, Refer (QPR)-trained staff will be referred for a mental health evaluation than in schools without QPR-trained staff.

Eligibility Criteria:
Inclusion Criteria for School Staff Members:

* Currently working as a staff member in Cobb County school district

Inclusion Criteria for Students:

* Parent or guardian willing to provide informed consent
Reasons for Emergency Department Utilization and Readmission in Postoperative 90 Days

The objective of this study was conducted to examine the reasons for patients' utilization of the emergency department and the rates of readmission in the first 90 days after surgery.

Background: Postoperative readmission rates of patients have been important indicators in the evaluation of quality service delivery and cost-effectiveness. This study was conducted to examine the reasons for patients' utilization of the emergency department and the rates of readmission in the first 90 days after surgery.

Material and methods: The research is based on actual patient data in the hospital information management system. In the study, the data of patients who had undergone surgery between January 1, 2018, and December 31, 2018, and presented to the emergency department in the first 90 days after surgery were retrospectively analyzed. Patient data about the date of surgery, type of surgery, department performing the surgery, patient age, gender, type of anesthesia, the length of postoperative hospital stay, date of discharge, date, and reason for presenting to the emergency department, and discharge status (admission, referral, discharge, or death, etc.) recorded on the hospital information management system were evaluated in accordance with "the 18 HIPAA" standards.

Eligibility Criteria:
Inclusion Criteria:

* Undergone surgery between January 1, 2018, and December 31, 2018,
* Presented to the emergency department

Exclusion Criteria:

• Patients who do not meet the inclusion criteria
Cash Transfers to Increase Dietary Diversity in Grand Gedeh County, Liberia

The investigators aim to evaluate the efficacy of a cash transfer and nutrition education program delivered by community health assistants to increase dietary diversity among children 6 to 23 months of age in Grand Gedeh County, Liberia.

Worldwide, more than one in five children suffer from chronic malnutrition. In Liberia, there are more than 230,000 children suffering from chronic malnutrition and 32% of children under five are stunted. Previous studies have shown that inadequate dietary diversity is strongly associated with stunting in children under two years of age. An interventional package including cash transfers and education has the potential to improve dietary diversity and long-term outcomes such as improved growth and reduced rates of stunting among children.

The investigators' objective is to evaluate the efficacy of a cash transfer and nutrition education program delivered by community health assistants to increase dietary diversity among children 6 to 23 months of age in Grand Gedeh County, Liberia. The investigators will conduct a pilot, cluster randomized trial in 45 communities. The investigators hypothesize that a multi-pronged interventional package aimed at strengthening the household environment will result in improved dietary diversity for children 6 to 23 months of age. Moreover, the investigators also hypothesize that unconditional cash transfers will result in improved dietary diversity for children 6 to 23 months of age in Grand Gedeh County, Liberia.

Eligibility Criteria:
Inclusion Criteria:

* Participants 6 to 23 months of age
* Participants with consenting caregivers to have monthly visits and to participate in the program
* Caregivers of all ages will be included

Exclusion Criteria:

* Participants who are younger than 6 months of age (children \< 6 months of age are encouraged to exclusively breastfeed, making dietary diversity irrelevant in this age group)
* Participants older than 23 months of age
* Participants with non-consenting caregivers
Sacubitril-valsartan Versus Usual Anti-hypertensives in LVAD

This pilot, feasibility study evaluates the efficacy of sacubitril-valsartan (Entresto) versus usual anti-hypertensive medications in patients with left ventricular assist devices (LVAD). It also measures diurnal blood pressure variations in the context of continuous flow physiology.

Left ventricular assist devices (LVAD) have become a life-saving therapy for patients with ACC/AHA stage D congestive heart failure (CHF). Despite longevity and improved quality of life, LVAD-supported patients are plagued with adverse events, the most debilitating of all is stroke. Ischemic and hemorrhagic strokes have been associated with hypertension (mean arterial pressure, or MAP \> 90 mmHg) in addition to out-of-range INR and aspirin doses. Strict blood pressure control has been shown in a recent randomized trial to confer a significant decline in stroke rates of patients implanted with the Heartware LVAD. Patients with poorly controlled hypertension are also at risk for inadequate left-ventricular unloading and worsening CHF due to the exquisite sensitivity to afterload of the continuous flow LVAD.

There are no guidelines for the use of anti-hypertensives in LVAD patients. Most are started on standard CHF therapies, though this practice varies greatly across LVAD centers. The angiotensin receptor blocker-neprilysin inhibitor sacubitril-valsartan (Entresto) is a potent anti-hypertensive mediation that was recently approved by the Food and Drug Administration for the treatment of patients with heart failure and low ejection fraction. We aim to randomly assign patients to receive Entresto or usual anti-hypertensive therapy for blood pressure control, then crossover to the other arm after 30 days. Daily blood pressure measurements will be performed and correlated with LVAD pump flows and waveform analysis.

Eligibility Criteria:
Inclusion Criteria:

* More than 30 days after LVAD implant
* Ambulatory
* MAP \> 85 mmHg requiring initiation of anti-hypertensive medications

Exclusion Criteria:

* Allergy to ACEI or ARB
* eGFR \< 30 mL/min/1.73m2
* K \> 5.4 mmol/L
* MAP \< 60
* Inability to check blood pressure at home
* Lack of prescription coverage
* Frequent hospitalizations (monthly)
Predicting Risk for Post-polypectomy Colorectal Cancer

This originated as an observational study of Kaiser Permanente Northern California (KPNC) patients with a history of adenoma diagnosed by colonoscopy who received a subsequent surveillance colonoscopy between 2014 and 2019. The original goal of the study was to develop a risk prediction model that would help identify patients at highest risk for a diagnosis of advanced neoplasia (colorectal cancer and/or advanced adenoma) at or within 6 months following their surveillance colonoscopy. Candidate predictors of interest included patient demographics, medical history, and details related to the index colonoscopy. The investigators are now at the implementation stage and applying the risk prediction model to patients awaiting surveillance colonoscopy at select KPNC service areas to help identify those at highest risk for colorectal cancer based on their risk scores.

In the implementation stage, the risk prediction model is being applied to patients who are awaiting surveillance colonoscopy at select KPNC service areas to help identify those at highest risk for colorectal cancer based on their risk scores. The prediction model is being used in 2-3 service area to identify about 60-80 patients per month who are at highest risk for colorectal cancer based on their risk scores. Risk scores represent one of a number of factors being considered for prioritizing patients for colonoscopy.

Eligibility Criteria:
Inclusion Criteria:

Patients are on the current colonoscopy pending list; excluding those who were fecal immunochemical test-positive, screening colonoscopies, had a colonoscopy in last 12 months or on a voluntary "pause" list

* Hereditary colorectal cancer syndrome (e.g. Lynch syndrome)
* Diagnostic, fecal immunochemical test -positive, or screening indication for colonoscopy
The Effects of Supplementation of Conjugated Linoleic Acid on Body Fat Reduction

This is a double-blinded randomized controlled trial, to evaluate the effectiveness of daily supplementation of 3.2 g CLA on body fat reduction and lipid profile in overweight or obese Chinese adults, during a lifestyle counselling-based weight loss.

This will be a parallel randomized, double-blinded, placebo-controlled trial. Sixty-six overweight or obese men and women aged from 18 to 45 years with elevated body fat percentage, who also meet our inclusion and exclusion criteria, will be randomly assigned to: the treatment group, daily supplementation of 3.2 g CLA (Cis-9, trans-11 isomers and trans-10, cis-12 isomers) plus lifestyle counselling weight loss program; or the control group, daily supplementation of sunflower oil. The intervention will include a 3-day run-in phase and 12-week interventional phase. At baseline and the end of the intervention, physical examination including questionnaires, anthropometric measurement, body composition by Dual Energy X-ray Absorptiometry (DXA), biological sample collection will be undertaken. During the invention, regular lifestyle counselling sessions will be delivered, and detailed record will be tracked for all participants to monitor and improve the adherence and safety.

Eligibility Criteria:
Inclusion Criteria:

1) Body fat percentage ≥ 20% for men, Body fat percentage ≥ 30% for women ; 2) aged from 18 to 45 years old.

Exclusion Criteria:

1. Pregnancy or lactation;
2. Abnormal liver or kidney function indicated by physical examination within 6 months;
3. Gastrointestinal problems that affect the complying with the procedure;
4. Sever cardiovascular disease;
5. Active cancer;
6. Mental diseases, epilepsy or using anti-depression drugs;
7. Using medicine that affect body weight;
8. Participating in other scientific studies within 3 months before the study.
Comparison of Verbal Rating Scale and Numerical Rating Scale in Post Anesthesia Care Unit

In the postanesthetic care unit(PACU), patients who are recovering from anesthesia are not easy to communicate with. Accordingly, accurate evaluation of acute surgical pain is difficult for PACU patients in spite of severe postoperative pain. Therefore, pain evaluation is clinically important and challenging in PACU. The pain evaluation tool should be simple and easy to understand for accurate assessment. Among the most commonly used pain assessment methods are numerical rating scale(NRS), visual analogue scale(VAS) and verbal rating scale(VRS). These three methods have proved valid for clinical situations in many studies. VRS appears to be easier to understand than the other two methods for patients in PACU. The purpose of this study is to compare NRS and VRS in PACU patients.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients who underwent general anesthesia
* The American Society of Anesthesiologists(ASA) physical status classification system : class 1, 2, 3

Exclusion Criteria:

* The American Society of Anesthesiologists(ASA) physical status classification system : class 4, 5
Hydrocodone For Pain Control in First Trimester Surgical Abortion

The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.

The investigators plan to conduct a double-blinded randomized placebo-controlled trial of 120 women undergoing elective first trimester surgical abortion. These women will be premedicated with either two tabs of 5/350 hydrocodone/acetaminophen or 2 tabs of a placebo. All subjects will receive ibuprofen and lorazepam preoperatively and a PCB. This study will examine the incremental benefit of HC/APAP over this standard medication regimen. Randomization will be stratified into two groups. Subjects less than 8 weeks gestation will comprise the early gestational age group. Subjects between 8 weeks 0 days and 10 weeks 6 days will comprise the late gestational age group. The investigators will be assessing patient perception of pain, nausea, satisfaction, and anxiety at multiple points during the clinic visit using 100-mm visual analogue scales (VAS).

Eligibility Criteria:
Inclusion Criteria:

* Aged 18 years or older
* Voluntarily requesting surgical pregnancy termination
* Pregnancy with intrauterine gestational sac up to 10 weeks 6 days gestation, dated by ultrasound
* Eligible for suction curettage
* English or Spanish speaking
* Good general health
* Able and willing to give informed consent and agree to terms of the study

Exclusion Criteria:

* Gestational ages 11 weeks or more
* Incomplete abortion
* Premedication with misoprostol
* Use of any opioid medication within the past 7 days
* Use of heroin within the past 7 days
* Requested opioids or IV sedation prior to start of the procedure
* Patients who refuse ibuprofen or lorazepam
* Contraindications or allergies to HC/APAP, lidocaine, ibuprofen, or lorazepam
* Significant medical problem necessitating inpatient procedure
* Adnexal mass or tenderness on pelvic exam consistent with pelvic inflammatory disease
* Known hepatic disease
36-Month Clinical Performance of Different Restorative Materials in the Treatment of Root Caries Lesions

This is a split-mouth, randomized clinical study that evaluating the 36-month performance of different restorative materials in the treatment of root caries lesions. A total of 110 restorations were randomly placed, half using resin composite (Spectrum TPH3) and the other half using the resin-modified glass ionomer cement (Riva Light Cure). Restorations were evaluated at the baseline, 6, 12, 18,24 and 36 months according to the USPHS criteria.

The aim of the study was to comparatively assess the 36-month clinical performance of a micro hybrid resin composite and resin-modified glass ionomer cement in root caries lesions.

Thirty-three patients with at least two root caries lesions participated in this study. A total of 110 restorations were randomly placed, half using resin composite (Spectrum TPH3) and the other half using the resin-modified glass ionomer cement (Riva Light Cure). Restorations were evaluated at the baseline, 6, 12, 18, 24 and 36 months. The data were analyzed with Pearson's Chi-square, Cochran's Q, Friedman tests and Logistic Regression Analysis (p=0.05).

Eligibility Criteria:
Inclusion Criteria:

* Root caries lesions (at least 1mm depth)

Exclusion Criteria:

* Complex medical history
* Poor dental hygiene/infrequent practise of oral hygiene habits
* Severe or chronic periodontitis
* Extreme carious activity
* Heavy bruxism
* Very deep (closer than 0.5 mm to the pulp) or superficial lesions (shallower than 1mm)
* Previously restored and abutment teeth for bridge or removable dental prostheses
Effects of Therapeutic Artistic Activities on the Mental Status of Adolescents Followed Up with Diabetes Diagnosis

This study will examine the effectiveness of therapeutic artistic activities in diabetic adolescents between the ages of 9-18. The study includes a 6-week program. The program will use art activities that can affect well-being, such as drawing a picture called a mandala. The State Anxiety Inventory will be used to measure the anxiety levels of adolescents, the Psychological Well-being Scale to assess their well-being, and a process evaluation form to evaluate the program (such as satisfaction).

This study will be conducted with adolescents between the ages of 9-18 who are diagnosed with Type 1 Diabetes. The study includes a 6-week program. Art activities that can affect well-being, such as drawing a picture called a mandala, will be used in the program. Mandala drawing and painting will be done with the adolescents in the second and fourth weeks of the study. The drawings will be discussed in the third and fifth weeks. A common storytelling technique will be used according to the adolescents; feelings about drawing and painting. In the study, the State Anxiety Inventory will be used to measure the anxiety levels of the adolescents, the Psychological Well-being Scale to evaluate their well-being, and the process evaluation form where they evaluate the program (such as satisfaction). In addition, the Descriptive Characteristics Form, which consists of questions such as age and grade, will be applied in the first week of the study.

Eligibility Criteria:
Inclusion Criteria:

Adolescents who agree to participate in the study and whose parents give written consent,

* Are between the ages of 9-18,
* Have been diagnosed with Type 1 Diabetes at least 6 months ago,
* Have internet access on their smartphone or computer,
* Have no other physiological or psychological illness,
* Do not use psychoactive drugs

Exclusion Criteria:

* Those who use insulin pumps,
* Those who have experienced a significant life event in the last 6 months (such as migration, death, divorce in the family)
* Those who have practiced another body-mind based practice in the last 6 months (such as yoga, guided imagery, etc.)
* Those who do not have internet access
Plasma Level of Mitochondrial DNA in Patients With ARDS and Its Clinical Significance

To observe the changes of plasma mitochondrial DNA (mtDNA) levels in patients with ARDS, and to explore its clinical significance.

60 patients who diagnosed as ARDS were included in this study.Then keep blood samples from these patients in the first day、the third day and the sveventh day,detect the mitochotndrial DNA level in plasma by real-time quantitative PCR. Recored Severity of illness and survival status of every patient within 28 days.Objective to evaluate the correlation between the level of mitochondrial DNA in plasma and the prognosis of the patients.

Eligibility Criteria:
Inclusion Criteria:

1. Patients admitted to ICU diagnosed of ARDS (Berlin criteria),
2. Patients age between 18 years old and 80 years.

Exclusion Criteria:

1. Pregnant women,
2. Patients with malignant tumor,
3. Immunosuppression or immunocompromised patients.
Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study

The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. The researchers aim to investigate the beneficial effects of regular well-dosed exercise on health and compare these findings with the effects of the extreme strains of marathon running. Subclinical injuries to heart and arteries are being investigated in different groups of runners, including obese participants.

Regular exercise leads to an improvement of cardiovascular risc factors in patients with coronary heart disease, atherosclerosis and metabolic disorders. Aerobic exercise has anti-inflammatory effects. In contrast, the exertional exercise of marathon running causes an acute pro-inflammatory impulse. This may lead to myocardial injury and, in case of preexisting plaques, may result in plaque rupture and acute myocardial infarction.

The researchers aim to define the critical role of inflammatory markers and cardiovascular risk factors as a predictor of an increased risk for myocardial and endothelial dysfunction in marathon runners.

The study groups are divided into average trained runners (40 km/week), average trained obese runners and highly trained runners (\> 70km/week). Training programmes are supervised by professional coaches. Individual scientific marathon contests are organized for the assessments.

Diagnostic tools include measurements of pulse wave velocity and heart rate turbulence, echocardiography and, for the first time, MRI-scans pre- and post marathon running. Additionally, cardiovascular markers such as endothelial progenitor cells (EPCs)and adiponectin are measured. Inflammatory markers include c-reactive protein (CRP), interleukins and tumor necrosis factor.

Eligibility Criteria:
Inclusion Criteria:

* Men aged 30-60 years
* Obese subjects: BMI \> 27 and waist circumference \> 102cm

Exclusion Criteria:

* manifested heart disease
* insulin dependent diabetes mellitus
* multiple drug therapy
* GFR \< 60 ml/min.
* claustrophobia
* metal implants
Short-term Effect of Rho-kinase Inhibitor on Retinal Circulation

Investigate changes in optical coherence tomography angiography of the optic nerve and macula following topical instillation of commercial preparations of netarsudil 0.02% ophthalmic solution.


Eligibility Criteria:
Inclusion Criteria:

* Normal ocular health

Exclusion Criteria:

* Females who are or may be pregnant or who are nursing
* Uncontrolled hypertension
* Allergy to netarsudil or latanoprost