cyrilzakka/clinical-trials huggingface dataset:
Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study

This is a quasi-experimental evaluation of psychoeducational course focusing on mindfulness and lifestyle changes for depression and anxiety; clients in active treatment group are compared to those in a treatment-as-usual wait-list control group. The primary hypothesis is that the psychoeducational course will result in lower levels of depression and anxiety as compared to the wait-listed treatment-as-usual comparison group.

This study evaluates a psychoeducational intervention: Teaching mindfulness and lifestyle interventions to adult clients who self-report problems with depression and/or anxiety. The course is eight weeks long. Clients are assigned to either (1) receive the course (COU condition) from October- December 2010 or (2) placed on a waiting list and receive treatment-as-usual (TAU condition). Those in the TAU group will be offered the course in January 2011.

Random assignment to COU or TAU conditions will be attempted although this may be relaxed due to institutional constraints.

Participants are assessed on the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) at the beginning of the course, on the last day of the course, at 1-month post-course, at 4-months post-course, and at 12-months post-course.

Participants in the COU condition will be compared to those in TAU condition at the beginning of the course, on the last day of the course, and at 1-month post-course. Further evaluations (4 and 12 months post-course) will be pre-post evaluations without a comparison group.

Eligibility Criteria:
Inclusion Criteria:

* Participants self-report as having depression or anxiety
* Adults (age 18 or above)
* Clients willing to participate in an 8-week psychoeducational course

Exclusion Criteria:

* A diagnosis of a psychotic disorder
* Unwilling to participate in 8-week psychoeducational course
Evaluation of SAFER Latinos' Program to Prevent Youth Violence

This is an evaluation of a primary prevention program to prevent youth violence by improving family cohesion, networking among families, school bonding, and access to services for Latinos in Langley Park, MD.

To prevent youth involvement in violence, outreach workers will work with families and youth to improve school bonding, family cohesion and awareness and utilization of existing services; and a youth drop-in center will provide youth with an adult supervised place to "hang out", do homework, or participate in sports and job training.

Following implementation of the intervention, we will collect detailed process data (regarding implementation), and evaluate impact/outcome using a quasi-experimental design with baseline (prior to intervention) and two followup data collections in both the intervention and a control community (Culmore, Virginia), measuring change in a selected set of aggregate community variables that represent mediating factors and outcomes for youth violence in Langley Park. Data will be collected via a survey and focus groups.

Eligibility Criteria:
Inclusion Criteria:

* youth 12-24 and their caregiver

Exclusion Criteria:

* residence outside of Langley Park or Culmore
The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery

Application of "Evicel" hemostatic matrix during operation for unilateral total knee replacement surgery (TKA) will result in decreased bleeding and postoperative drain output, a reduction in transfusion requirements, and less reduction of hemoglobin.

No additional data desired

Eligibility Criteria:
Inclusion Criteria:

- Diagnosis of degenerative joint disease of the knee in patients medically suitable to undergo unilateral total knee arthroplasty

Exclusion Criteria:

* Known allergies to human blood products.
* History of bleeding disorders.
* Patients with previous arthrotomy, however, with exception of medial or lateral menisectomy.
* Patients taking Lovenox, Plavix, Aggrenox or erythropoetin. (coumadin is acceptable)
* Additionally, any patient with an intra-operative complication (i.e bone fracture, vascular injury) or post-operative complication that would affect bleeding tendency will be excluded although data will be recorded for later analysis. Also, any patient who has a complication with the suction drain (eg inadvertently being pulled out, suction failing) will have the remaining data points recorded and drain measurements will be excluded from analysis.
Role of NLRP6 in Chronic Periodontitis

The quantification of NLRP6 in blood samples will be analyzed from individuals with chronic periodontitis but without systemic disease. Demographic and periodontal parameters will be assessed and correlated with the NLRP6 quantification using RT-PCR.

This study aims to collect demographic variables, including age, education level, BMI, personal habits, medication use, and history of systemic disease, from non-smoking individuals with chronic periodontitis. Initially, we will determine the expression level of the NLRP6 gene in blood samples taken from chronic periodontitis subjects who are matched for age and sex. Subsequently, we will investigate the relationship between gene expression levels, taking into account the confounding effect of body mass index, and explore how these levels correlate with the severity of the disease.

In this study, two groups: chronic periodontitis (CP) and healthy controls (HC) will be examined. The CP group will consist of patients diagnosed with Stage I to IV periodontitis based on the consensus report from the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Additionally, we will include systemically healthy individuals. Serum samples will be collected from all patients, and the Plaque Index (PI) and Gingival Index (GI) will be recorded at four sites per tooth. Furthermore, we will assess full-mouth probing depth (PD) and clinical attachment level (CAL) at six sites per tooth. The percentage of bleeding areas will be documented as the proportion of sites with bleeding on probing (BOP) within 20 seconds after probing.

For blood sampling, a total of 3 mL of blood will be collected from the antecubital vein of each individual by an expert nurse from the Department of Periodontology.

Statistical analysis will be conducted using statistical software for data science (Stata version 17). A significance value (p-value) of less than 0.05 will be considered statistically significant. The sample size for the study was determined using the power paired means module in Stata 17. We planned to include at least 25 individuals in each group, aiming for a significance level of 5%, statistical power of 80%, and a correlation coefficient of 0.2.

Eligibility Criteria:
Inclusion Criteria:

* Age: At least 25 years old
* Clinical diagnosis of chronic periodontitis
* At least 15 teeth in the mouth

Exclusion Criteria:

* premalignant lesions and cancer of the oral cavity
* periodontal treatment in the last 6 months
* systemic disorders affecting the periodontal condition (autoimmunity and endocrine disorders)
* diabetes mellitus and rheumatoid arthritis
* pregnancy or breastfeeding
* taking drugs with the possibility of affecting the periodontal condition (calcium channel blockers, anticonvulsants, etc.)
* Smoking
* aggressive PD
Deep Learning Algorithm for the Diagnosis of Gastrointestinal Diseases Depending on Tongue Images

The purpose of this study is to analysize the relationship between the characteristics of tongue image and the diagnosis of gastrointestinal diseases , then develop and validate a deep learning algorithm for the diagnosis of gastrointestinal diseases depending on tongue images, so as to improve the objectiveness and intelligence of tongue diagnosis. At the same time, gastrointestinal flora of common tongue images were analyzed in order to provide a microecological basis for understanding the relationship between tongue images and digestive tract diseases.

Tongue diagnosis is an important part of traditional Chinese medicine.According to traditional Chinese medicine theory,health condition can assessed by observing tougue features,including color, gloss, shape and coating of the tongue, tongue features reflect gastric mucosal state, disease classification and prognosis. Recently, deep learning based on central neural networks (CNN) has shownTongue diagnosis is an important part of traditional Chinese medicine.According to traditional Chinese medicine theory,health condition can assessed by observing tougue features,including color, gloss, shape and coating of the tongue, tongue features reflect gastric mucosal state, disease classification and prognosis. Recently, deep learning based on central neural networks (CNN) has shown multiple potential in detecting and diagnosing gastrointestinal diseases. However, there is still a blank in recognition of gastrointestinal diseases .This study aims to develop and validate a deep learning algorithm for the diagnosis of digestive tract diseases depending on tongue images,and analyze gastrointestinal flora of common tongue images.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 - 80 years undergoing endoscopic examination;patients gave informed consent and signed informed consent.

Exclusion Criteria:

-
LIPT - Liraglutide in Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) affects 5-10% of women in fertile age. PCOS is associated with metabolic syndrom, diabetes and and increased risk og cardiovascular disease.

The study investigates the effect af intervention with GLP-1-analog on risk markers of cardiovascular disease in women with PCOS.

70 women will be included in af RCT.

Hypothesis: GLP-1-analog treatment in women with PCOS (without diabetes) will result in a beneficial reduction in risk markers of vascular thrombosis and early cardiovascular disease.


Eligibility Criteria:
Inclusion Criteria:

* PCOS
* \>18 years
* premenopausal
* BMI \>25 og 25 and thereunder + insulin resistent

Exclusion Criteria (including):

* actualt or intended pregnancy
* inadeqvat contraception
* hormonal contraception within 6 weeks
* metfoomin, GLP-1-analog or DPP IV inhibitor within 3 months
* medications affectiv hemostatic mechanisme
* diabetes or other severe comorbidity
* familar MEN
* ...
The PRESS RA: Protein and Resistance Exercise Supplementation Study for Rheumatoid Arthritis

This study will evaluate if the combination of resistance exercise and protein supplementation will increase muscle strength and muscle mass among older individuals with rheumatoid arthritis (RA).

This study proposes a randomized trial to evaluate a tailored 16-week resistance exercise program, in combination with protein supplementation, for older individuals with RA. The exercise protocol in this study is distinctive because it combines dynamic and isometric (static) resistance exercise performed on specialized equipment that can accommodate the range of motion limitations frequently encountered in the older RA population. This study will also begin to evaluate if additional benefit can be achieved with daily protein supplementation

Eligibility Criteria:
Inclusion Criteria:

* age 60-95 years
* diagnosis of rheumatoid arthritis
* willing to participate in twice weekly exercise sessions

Exclusion Criteria:

* cognitive impairment
* recent heart surgery (within past 12 months)
* severe kidney disease
* use of supplemental oxygen
* presence of pacemaker
* diabetes that requires insulin for management
* allergy to soy or milk
Neostigmine for Ultrasound Guided Supraclavicular Brachial Plexus Block

Patients were randomly allocated into Two equal study groups each contain (40) patients : Patients in Group A received supraclavicular block using 25mL of 0. 5% bupivacaine and 1 mL normal saline and patients in Group B received 25 mL 0. 5% bupivacaine and 1 mL neostigmine (0.5 mg).

The investigators found that neostigmine when used as an adjuvant to bupivacaine in ultrasound guided supraclavicular brachial plexus block has advantage over bupivacaine alone especially in the quality of sensory block and provide safe and effective post-operative analgesia in patients undergoing forearm surgeries

All patients were assessed with regards to:

Hemodynamics (heart rate, Bp) and oxygen saturation were recorded preoperatively just before the block as a baseline value, immediately after the block 5, 20, 30,40,45 , 60 minutes during the operative time and 1, 2, 4, 6, 9 and 12 hours after end of operation.

Onset time of sensory block, Onset time of motor block, Duration of sensory block, and Duration of motor block.

Pain assessment using a scoring system based on the visual analogue pain scale(VAS) measured at the following time intervals 0, 2, 4, 6, 9, 12 and 24 post operatively, time to first analgesic requirement (in hours) and total analgesic consumption was monitored in the two groups for 24 hours in ward.

The incidence of adverse effects whether related to the drugs used in the technique or related to the technique itself were recorded.

The results of this study found that demographic (age, sex, weight and ASA classification and surgical duration were statistically insignificant between the two groups.

Hemodynamics (HR and Bp) were statistically significant between the groups .They were lower in Neostigmine groups.

As regard onset of sensory and motor block were clinically and significantly earlier in group B than group A ( p \< 0,05) and the same for duration of sensory and motor block were clinically and significantly longer in group B than in group A ( P \< 0,05 ). Regarding Visual Analogue Pain Scale (VAS), while comparing the two groups, the differences were significant at 9 and 12 hours after surgery for the favor of the neostigmine groups . The time to first analgesic request was significantly longer in group B than group A.

Eligibility Criteria:
Inclusion Criteria:

1. ASA ( I-II)
2. Age: from ≥18 years
3. Sex: male or female
4. type of operation : Forearm Orthopedic surgeries
5. Type of anaesthesia : supraclavicular brachial plexus block
6. Duration of operation : 60-90 min

Exclusion Criteria:

1. Patient refusal for the procedure
2. Any bleeding tendency
3. Neurological deficits involving brachial plexus
4. Patients with allergy to local anesthetics
5. Local infection at the site of injection
6. Patients on any sedatives or antipsychotics
7. Body mass index \>35.
Radiographic Assessment of Three Dimensional Mandibular Position Using Splint-less Patient Specific Implant

The purpose of this study was to assess the accuracy of a splint-less approach for mandibular jaw orthognathic surgery. This approach utilized a personalized orthognathic surgical guide (POSG) system, which comprised a set of cutting guides and 3D printed custom titanium fixation plates for bilateral sagittal split osteotomies (BSSOs).

The cutting guides were first used to predrill screw holes and guide osteotomies.

The custom plates were then used to reposition and stabilize the bony segments as planned, without the use of surgical splints or any additional tool such as surgical navigation

Surgical technique:

The buccal bony surface of the mandible was exposed as a routine sagittal split osteotomy. First, the mandibular cutting guide was installed using the tooth-borne splint portion of the guide.

Second, the lower portion of the guide was temporarily fixed with titanium screws through the designed screw holes on the guide. The planned margins for vertical osteotomy/ ostectomy were then marked by a pencil.

Once the cutting guide was removed, the sagittal split osteotomy was completed as usual. Finally, the distal and proximal segments were fixed together using the custom plates and screw holes that were used by the cutting guide.

Accuracy of preoperative surgical planning, and validation of the use of patient specific implants (PSI) in bilateral sagittal split osteotomy (BSSO) by comparing the planned outcomes to the actual postoperative outcomes by two methos.

A)Evaluation the discrepancy between planned and obtained post-operative position of the mandibular plates, rami, and occlusion by analyzing the discrepancies in terms of rotation (roll, pitch and yaw) and translation (antero-posterior, lateral and vertical). These movements were determined by incorporating the segments in homologous bounding-boxes, aligning the planned model to the post-op result colorimetric map inspection.

B) Measurements of the linear differences between the planned and postoperative positions of the mandibular midlines, the chin, and the gonial angle.

Eligibility Criteria:
Inclusion Criteria:

1. Patients suffering from skeletal deformity requiring mandibular orthognathic surgery (Bilateral sagittal splitting osteotomy).
2. Patients should be free from any systemic disease that may affect normal bone healing and predictable outcome.

Exclusion Criteria:

1. Patients with metabolic bone disease that affects bone healing.
2. Intra-bony lesions that may affect the osteotomy healing.
3. Patients with history of radiotherapy on the head and neck region
Natural Cycle In Vitro Fertilization

Natural IVF study patients will undergo an IVF cycle with trigger shots of Lupron \& hCG. Patients will not be given any other stimulating medications during the cycle. They will have 2 uterine aspirations and an endometrial biopsy at designated times. The first uterine aspiration will be randomized to one of four days (day before retrieval, day of retrieval, day after retrieval or 2 days after retrieval). The second uterine aspiration and endometrial biopsy will be performed 6 days after retrieval. Any embryo(s) obtained will be biopsied for Comprehensive Chromosome Screening (CCS) and frozen for use in a subsequent thaw cycle.


Eligibility Criteria:
Inclusion Criteria:

* Ovulatory cycles every 39 days or less (natural cycle IVF cannot be performed in someone who does not have cycles)
* Must be RMANJ patient and have completed all diagnostic screening at one of our RMANJ locations. All diagnostic screening is NOT covered under the study and must be completed prior to being allowed to start the study cycle.

Exclusion Criteria:

* Prior enrollment/attempt in this study
* Requirement for surgical sperm extraction
* Inability to assess ovaries via transvaginal ultrasound
* Inability to tolerate vaginal examination
Assessment of the Relationship Between Edema Measurement Methods After Impacted Mandibular Third Molar Surgery.

The aim of this study is to evaluate the correlation between two point distance measurements performed by surgeon on patients face with foldable ruler, which is the most commonly used method, and the subjective scoring will be done by the patient with the help of the edema scale, for measuring edema.

The patients will be selected among the patients who apply for mandibular impacted third molar extraction to Necmettin Erbakan University, Faculty of Dentistry. A total of 60 patients will be included. All third molar operations will be carried out by the same surgeon in all groups with the same technique.Two methods will be used to evaluate the edema on the face.

1. Method The surgeon will measure from three different places on the patient's face ( two point distance) with the help of a paper ruler.

   * Tragus-Pogonion
   * Tragus-Labial Komissura
   * Angulus Mandibula-Lateral Kantus Measurements will be made preoperative, postoperative 2. and 7. days and saved as milimetre.
2. Method Patients will be given edema scale.With the help of the edema scale, the patients will be evaluated the edema by themselves. When the patient stand in front of the mirror, they will be assessed the edema on their face. And a value between 0 and 4 will be pointed on the scale postoperative 2. and 7. days.

A correlation between the results of the first and second methods will be examined.

Eligibility Criteria:
Inclusion Criteria:

* Impacted mandibular third molar teeth (mesioangular, mucosa and bone retantion)
* Patients with any chronic disease and allergy

Exclusion Criteria:

* Smoking
* Pregnancy or lactation
* pericoronitis
Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis

The goal of the project is to study the risk of coccidioidomycosis (valley fever) in patients receiving anti-TNF and other biologic agents for inflammatory arthritis in Tucson, Arizona.

Retrospective chart review of all patients with an inflammatory arthritis seen at the University Rheumatology clinic since January 2000.

Eligibility Criteria:
Inclusion Criteria:

* All active patients with an inflammatory arthritis seen at the University of Arizona from January 2000

Exclusion Criteria:

* None
Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Visually Induced Motion Sickness in Healthy Volunteers

Nausea is a common and distressing experience that often precedes vomiting. Amongst symptoms emanating from the gastrointestinal (GI) tract nausea can be considered somewhat unique, as on one hand it represents a normal, highly conserved, physiological response to an ingested toxin yet on the other it may indicate pathology. Nausea may also arise as a consequence of pharmaco- and chemotherapeutic interventions. Nausea negatively impacts on quality of life, adherence to treatment and is a cause for discontinuation of the development of novel compounds. Experimentally, nausea can be induced in humans using a visually induced motion stimulus. Previously we have developed a 10-minute motion video of the landscape rotating as seen from the perspective of a subject standing on Westminster Bridge, London. The tilted and rotating view visual display makes the subject perceive that they are spinning round and round on a spot tilted away from centre of gravity due to circular vection. This motion video induced nausea in approximately 50% of healthy participants and caused a reduction in cardiac vagal tone, a validated measure of the parasympathetic nervous system branch on the autonomic nervous system. We therefore are evaluating the role of external transcutaneous vagal nerve stimulation in visually induced motion sickness.


Eligibility Criteria:
Inclusion Criteria:

1. Healthy subjects, aged 18-65, from staff, students and local population of Queen Mary, University of London.
2. Inclusion will be determined on the basis of availability, with no prior selection bias included. They should be able to attend the Wingate Institute for at least 2 x 1 hour sessions.
3. Subjects who score \>15 on MSSQ (suggesting that they are sensitive to visually induced nausea).

Exclusion Criteria:

1. Subjects unable to provide informed consent.
2. Subjects with any systemic disease or medications that may influence the autonomic nervous system (e.g. beta-agonists or Parkinson's disease).
3. Subjects who score \<15 on MSSQ (suggesting that they are insensitive to visually induced nausea).
4. Pregnant females to prevent any confounding effects on pregnancy related nausea.
Gene Expression in Patients With Advanced or Metastatic Colorectal Cancer Receiving Bevacizumab

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors understand how patients respond to treatment.

PURPOSE: This laboratory study is looking at gene expression in patients with advanced or metastatic colorectal cancer receiving bevacizumab.

OBJECTIVES:

* Determine whether the balance of splice form expression alters susceptibility of tumors in vivo to respond to anti-VEGF therapy.

OUTLINE: Tumor tissue samples collected on clinical trial E-3200 are analyzed for laboratory endpoints.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Tumor tissue samples available from patients with advanced or metastatic adenocarcinoma of the colon or rectum

  * Receiving bevacizumab on clinical trial E-3200

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics