cyrilzakka/clinical-trials huggingface dataset:
Cognitive Adaptation

A hallmark of our survival in the real world and of our capacity to navigate the complex social interactions of human society is our ability to show behavioral adaptation. Adaptation can be necessary for a number of reasons, making the study of the process challenging. Two classes of event can signal a need for adaptation: 1) Events caused by one's own actions and specifically FeedBack -FB- from those actions (e.g. the investigators adapt their strategy after an erroneous choice), and 2) Events not linked to our actions, specifically Action-InDependent Events -AiDE- (e.g. the investigators adapt their strategy after a change of rule). These two types of information - FB and AiDE - will frequently occur concurrently. A critical and difficult part of adapting appropriately involves resolving the difference between the two. So for example an incorrect FB can occur because the investigators made an error, or because something unexpected in the environment has changed -the rule switched, someone cheated, etc. The Investigators must work out which it is, as they will frequently require different behavioral adaptations. Their task is made even more complex by the fact that the dynamics of evidence accumulation after FB vs AiDE are very different. FB has a direct temporal and causal link to an executed action, which means that the investigators are certain to derive information about a given action from a given FB. In contrast, AiDE have no such contiguity and no initial relation to actions, which means that the investigators must accumulate evidence to identify the appropriate adaptation to an AiDE. So the crucial dilemma is this: after an unwanted outcome, should the investigators adapt as if they made an error and received a negative FB, or should they continue to accumulate evidence as if there has been an AiDE to which they need to know how to adapt. Animals are able to resolve this credit assignment problem, as evidenced by their ability to appropriately adapt their behavior. A breakdown of this ability to link unexpected events to their correct cause would seem to be at the source of impairments in a wide range of psychological and neurological disorders, from addiction and OCD to psychological symptoms in Parkinson's disease. Yet the neural basis of this process is currently unknown, and FB and AiDE processing have been assessed separately so far. ADAPCO will provide unprecedented characterization of brain systems critically involved in learning from and adapting to FB, AiDE, and their interactions, thanks to fMRI studies.


Eligibility Criteria:
Inclusion Criteria:

* being able to provide a written consent form
* having a social insurance
* have a normal vision (with or without corrections)
* Right-handed

Exclusion Criteria:

* Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc...).
* Subjects must be willing to be advise in case of discovery of brain abnormality.
* History of neurological or psychiatric illness
* Pregnant or nursing women
* Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of liberty
Anger and Cardiovascular Risk in Urban Youth

To examine anger and cardiovascular disease risk in urban youth. The project studied patterns of hemodynamic responses to social and nonsocial stressors, ambulatory blood pressure (BP), fasting insulin, fasting glucose, lipid profiles, and central obesity in adolescents from a wide range of socioeconomic status (SES) backgrounds.

BACKGROUND:

Urban adolescents at high risk for cardiovascular disease (CVD) exhibit a pattern of hemodynamic responses that: (a) is evoked by social encounters that arouse anger, defensiveness, and distrust; (b) appears related to increased insulin resistance; (c) is more pronounced in males and African Americans; and (d) may constitute a pathway via which chronic exposure to stressful social environments increases CVD risk.

DESIGN NARRATIVE:

There were four studies. Study 1 in the first two years measured hemodynamics in 200 subjects to test the hypothesis that hostile distrust was associated with increased total peripheral resistance (TPR) response to social challenge, and that adolescents exhibiting this response pattern had elevated levels of ambulatory BP, fasting insulin, glucose, blood lipids, and central obesity. Study 2 followed 200 subjects for four years to determine if defensive hostility and distrust were related to tracking at higher levels of BP (measured every 6 months), and insulin/ glucose/ cholesterol (measured once per year). Study 3 in years 3 and 4 evaluated the influence of race on the cross-situational consistency of hostile distrust/BP by measuring the latter responses in 200 adolescents during structured encounters with a friend of the same race and sex, an unfamiliar same-race peer, and an unfamiliar other-race peer (black or white). Study 4 evaluated video and audiotape recordings from Studies 1 and 3 to test the hypothesis that distrustful individuals expressed more hostile affect in encounters with others, elicited more negative treatment, were perceived as hostile regardless of observer race or gender, and thus experienced chronic, health-damaging interpersonal stress. Study 4 data were used to examine the possibility that hostile distrust is related to exposure to crime, poverty, and racial discrimination.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility Criteria:
PRoMOTE Follow-up Observational Study

The purpose of the study is:

* To evaluate the Heart Failure Risk Status (HFRS) feature performance.
* To establish the feasibility of remote follow-up in which patient risk triaging is performed by nurse-led review of HFRS feature as supplemental information.


Eligibility Criteria:
Inclusion Criteria:

Patients that meet all of following criteria could be included in the study:

* Implant of a commercially available Medtronic CRTD or ICD device with or without the Optivol Fluid Status Monitoring feature.
* Inclusion in the Medtronic Carelink Network.
* Local consent available for CL network as well as general local consent available for the use of data in observational studies signed and informative sheet delivered.

Exclusion Criteria:

* Patients under the age of 18 years.
Effect of Vestibular Stimulation on Sleep in Elderly

Vestibular stimulation might be beneficial for sleep. Previous research demonstrated that lateral rocking movements can facilitate the transition from wake to sleep during an afternoon nap. However, the relationship between rocking movements and sleep is poorly understood to date. Furthermore, studies looking at the effects of rocking on sleep have not yet been performed in an elderly population. Due to age related changes in sleep, people often experience a decrease in sleep efficiency and sleep quality later in life. Therefore, it is particularly this population that could benefit from a possible enhancement in sleep efficiency and sleep quality. In order to assess the effect of vestibular stimulation on sleep and sleep-dependant memory, measurements of two nights with stimulation will be compared to two baseline nights. The primary outcomes are changes in sleep onset, sleep architecture and power density spectra of the EEG due to vestibular stimulation. Secondary endpoints are sleep dependent changes in memory, the proximal-distal temperature gradient, cardiorespiratory variables and dream content.


Eligibility Criteria:
Inclusion Criteria:

* Right handed
* Between 60 and 75 years of age

Exclusion Criteria:

* Diseases or lesions of the nervous system (acute or residual included neurological and psychiatric diseases)
* BMI \< 19 or \> 30 kg/m2
* Medication known to influence sleep \[56\]
* Cognitive Impairment (MoCA score \< 26)
* Drug use and abuse
* Nicotine use (e.g. smoking)
* \> 10 alcoholic drinks per week
* \> 5 drinks or foods containing caffeine per day
* History of sleep disorder (Insomnia, sleep apnea (apnea-hypopnea index \>5), nocturnal myoclonus (\>5 periodic leg movements per hour of sleep))
* Irregular sleep-wake rhythm (e.g. shift working)
* Travelling across time zones less than 1 month ago
* Naps longer than 1h
* Sleep on an average night \<6 hours or \>8 hours
* Skin allergies or very sensitive skin
* Diseases of the vestibular system
* Signs of motion sickness based on questionnaire
Automated Cervical Cancer Screening Using a Smartphone-based Artificial Intelligence Classifier

Cervical cancer remains a major public health challenge in low- and middle-income countries (LMICs) due to financial and logistical issues. The World Health Organization (WHO) recommendation for cervical cancer screening in LMICs includes Human Papillomavirus (HPV) testing as primary screening followed by visual inspection with acetic acid (VIA) and treatment. However, VIA is a subjective procedure dependent on the healthcare provider's experience. Therefore, an objective approach based on quantitative diagnostic algorithms is desirable to improve performance of VIA.

With this objective and in a collaboration between the Gynecology and Obstetrics Department of the Geneva University Hospital (HUG) and the Swiss Institute of Technology (EPFL), our group started the development of an automated smartphone-based image classification device called AVC (for Automatic VIA Classifier). Two-minute videos of the cervix are recorded during VIA and classified using an artificial neural network (ANN) and image processing techniques to differentiate precancer and cancer from non-neoplastic cervical tissue. The result is displayed on the smartphone screen with a delimitation map of the lesions when appropriate. The key feature used for classification is the dynamic of cervical acetowhitening during the 120 second following the application of acetic acid. Precancerous and cancerous cells whiten more rapidly than non-cancerous ones and their whiteness persists stronger overtime.

Our aim is to assess the diagnostic performance of the AVC and to compare it with the performance of current triage tests (VIA and cytology). Histopathological examination will serve as reference standard. Participants' and providers' acceptability will also be considered as part of the study.

The study will be nested in an ongoing cervical cancer screening program called "3T-approach" (for Test, Triage and Treat) which includes HPV self-sampling for women aged 30 to 49 years, followed by VIA triage and treatment if needed. The AVC will be evaluated in this context.

The study's risk category is A according to swiss ethical guidelines. This decision is based on the fact that the planned measures for sampling biological material or collecting personal data entail only minimal risks and burdens.


Eligibility Criteria:
Inclusion Criteria:

* Free and informed consent to take part in the study on a voluntary basis

Exclusion Criteria:

* No initiation of sexual intercourse
* Pregnancy at the screening consultation
* Any condition altering the cervix visualization at the screening consultation (e.g. heavy vaginal bleeding)
* History of anogenital cancer or known anogenital cancer at the screening consultation
* Previous hysterectomy
* Not sufficiently healthy to participate in the study
Assessment of One-shot Cardiac-cervical-intracranial MRI in the Etiological Work up of Ischemic Stroke and Transient Ischemic Attacks

Stroke is a major public health issue in developed countries. A full etiological work up within a short time is critical to implement the appropriate preventive treatment. The etiological work up is actually based on a clinical examination and on a group of paraclinical examinations. The realization of the standard strategy is time consuming, and increase the cost of the medical care. A non-invasive one-shot examination of the heart, the aorta and the cervical and intracranial arteries (cci-MRI) could overcome these disadvantages.The investigator therefore propose to carry out an overall assessment of the performance of the cci-MR in the etiological work up of ischemic strokes and TIAs compared to the reference strategy


Eligibility Criteria:
Inclusion Criteria:

* • Man or woman aged from 18 to 85 years old,
* Patients victims of an ischemic stroke or a TIA in the 2 days before inclusion, Symptoms thought to be consistent with TIA were those defined by the ad hoc Committee established by the Advisory Council for the National Institute of Neurological and Communicative Disorders and Stroke65
* Rankin score: mRS ≤3
* Patient having given their free written and informed consent, or preliminary oral informed consent attested by a third party followed by signed informed consent as soon as possible,
* Affiliated to a social security scheme or equivalent,
* That are not the subject of any legal protection measures

Exclusion Criteria:

* •TIA symptoms limited to isolated numbness,
* changes, or isolated dizziness/vertigo
* Agitation, severe swallowing
* Contraindication to an MRI and the injection of gadolinium,
* Known history of hypersensitivity to the MRI contrast product,
* Risk of pregnancy or known pregnancy revealed when questioned, Breastfeeding,
* Patient unable to understand or poorly understanding French.
Effect of Dietary Supplements on the Oral Microbiome

The oral cavity's microbiome is a diverse community, hosting over 700 bacterial species. Due to its varied niches, the oral cavity constitutes a highly complex environment where different microbes preferentially colonize distinct habitats.

The aim of the study was to investigate the alteration of the oral microbiome during therapy with fixed orthodontic appliances using dietary supplements.

In the randomized clinical trial, the effect of dietary supplements (vegetable juice) was investigated in patients treated with fixed orthodontic appliances. Saliva, tongue and subgingival samples were taken from each participant at three different time points: TO (before insertion of fixed orthodontic therapy), T1 14 days after daily administration of lettuce juice; T2 up to 6 months after washout. Orthodontic patients without dietary intervention served as controls. In addition, clinical indices were examined. Samples were analyzed by Illumina 16S rRNA sequencing and taxonomically assigned.

Eligibility Criteria:
Inclusion Criteria:

* Patient age 12 to 99 years
* Good general condition, healthy
* Inflammation-free marginal periodontium
* Metal brackets in the upper and lower jaw

Exclusion Criteria:

* History of allergies
* Self reported as being immunocompromised
* Self-reported as pregnant or nursing
* Self-reported serious medical conditions
* Antibiotic or anti-inflammatory medication within 6 months before screening visit
* Smoker
A Musculoskeletal Ultrasound Course for Orthopedic Surgery Residents

A group of orthopedic surgery residents underwent a structured online and practical musculoskeletal ultrasound course. Their proficiency on a written and practical exam, as well as frequency and comfort when using was recorded prior to the course, immediately after, and 6 months after the course.

Musculoskeletal ultrasound (MSK-US) can have many uses for orthopedic surgeons, such as assisting in clinical diagnosis for muscle, tendon and ligament injuries, providing direct guidance for joint injections, or assessing the adequacy of a reduction in the emergency department. However, proficiency in sonography is not a requirement for certification in orthopedic surgery in Canada, and orthopedic trainees are rarely exposed to the subject. This project aims assess the usefulness in clinical education of a newly implemented MSK-US course in an orthopedic surgery program.

An MSK-US course for orthopedic surgery residents has been developed. An online survey covering the level of training of the resident, their prior experience with ultrasound (number of times used by month) and their comfort level with different parts of the examination (numeric analog scale - NAS), was filled by the participants prior to the course. A pre-course written and practical test was also given to the residents. Following the course, the participants were reassessed with the same tests and surveys on the same day as the course, and at 6 months post. Change in frequency of use, comfort level and test scores were assessed using a Kruskal-Wallis ANOVA and post-hoc Wilcoxon tests.

It was expected that residents' frequency of use, comfort level and tests scores would improve following the implementation of the course. The results were expected to be maintained at the 6 months endpoint.

Eligibility Criteria:
Inclusion Criteria:

* Be an orthopedic surgery resident
* Training at the University of Manitoba
* Post-graduate year (PGY) one to five

Exclusion Criteria:

* Residents having less than six months of training left before graduation
* Residents on extended leave (for example: completing graduate studies abroad, parental leave, and sabbatical)
Clinical Presentation and Renal Outcome of Patients With Tuberous Sclerosis Complex and/or Renal Angiomyolipoma in the Great West Region of France

This study aims to investigate the factors (clinical, care-related and genetic) affecting renal outcome in patients with TSC (Tuberous sclerosis complex)


Eligibility Criteria:
Inclusion criteria of study participants

* Patient presenting with an isolated angiomyolipoma or
* Patient presenting with tuberous sclerosis complex combined with an angiomyolipoma or
* Patient presenting with tuberous sclerosis complex
* Patient not objecting to the study

Exclusion criteria of study participants

■Patient objecting to the study
Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy

Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with uncomplicated pregnancies. This research investigates a patient-centered intervention during the postpartum period to promote engagement in cardiovascular preventive care.

Current evidence demonstrates that women with hypertensive disorders of pregnancy have 2-fold higher risk for the later development of cardiovascular disease (CVD) compared to women with healthy pregnancies. CVD prevention is a high priority for women's health, as it is the leading cause of death among women in the United States. In order to improve women's cardiovascular health, interventions for cardiovascular prevention could be initiated shortly after a pregnancy complicated by a hypertensive disorder. However, patient-centered interventions to promote preventive care engagement among postpartum women are lacking. Our objective is to address current gaps in knowledge regarding needs, values, and barriers regarding cardiovascular prevention among postpartum women with hypertensive disorders of pregnancy, and to remedy the lack of available evidence-based interventions for this at-risk population. To this end, we will conduct a pilot study to demonstrate feasibility and preliminary efficacy of a patient decision aid to improve patient knowledge and self-efficacy regarding CVD prevention during the postpartum period

Eligibility Criteria:
Inclusion Criteria:

* Delivered a pregnancy complicated by a hypertensive disorder of pregnancy at the University of Utah during the current hospital admission
* Ability to speak and read English or Spanish
* Written informed consent obtained

Exclusion Criteria:

* Cardiovascular disease diagnosis (history of peripheral artery disease, stroke, or myocardial infarction)
* Impairment of cognitive function or vision that prohibits communication and/or reading the decision aid.
Recombinant Human Granulocyte Monocyte - Colony Stimulating Factor (GM CSF) for Prevention of Pneumonia in Patients With Cirrhosis

Informed consent obtained from the patient or the patient's legal surrogate. The window for randomization and initiation of study drug infusion is 2 days from day of Admission. All further time points are relative to the day of randomization. Patients will be randomized (1:1) to receive either recombinant human GM-CSF or placebo. Using randomized block design of 10 each generated by computer and provided in sequential, sealed, opaque envelopes. Subjects will be stratified based on Child status. Patients who fulfil the inclusion criteria will receive either slow IV infusion of GM CSF (Sargamostatim-250mcg/M2) over 4 hour and inhalation of same dose by micronebulizer for 7 days OR Placebo(saline infusion and saline nebulization). Standard medical care will be given in both limbs.


Eligibility Criteria:
Inclusion Criteria:

* Patient with cirrhosis admitted to ICU-HDU without pneumonia at admission
* 18-70 years of Age
* Child B/ C

Exclusion Criteria:

* Patient having pneumonia
* If there is evidence of preexisting chronic respiratory failure
* If the patients is neutropenic (absolute neutrophil count \<1000 cells/mm3
* If there was a history of hematological malignancy or bone marrow transplantation
* Person having HCC
* Acute liver Failure
* Pregnancy
* HIV
Comparison of Immunization Schedules of Inactivated Hepatitis A Vaccine and Combined Hepatitis A and Hepatitis B Vaccine

The purpose of this study is to compare the immunogenicity and safety of three different immunization schedules of inactivated hepatitis A vaccine (HAV) and/ or combined hepatitis A and B vaccine (HABV) in healthy Chinese infants.

This study is a randomized double-blind, single-center, phase IV clinical trial. The purpose of this study is to compare the immunogenicity and safety of three different immunization schedules of inactivated hepatitis A vaccine (HAV) and/ or combined hepatitis A and B vaccine (HABV) in healthy Chinese infants between 18 and 24 months old. The subjects were randomly assigned into 3 groups. Subjects in group 1 each received 2 doses of HAV with a 6-month interval (at day 0 and month 6); subjects in group 2 each received 1 dose of HAV at day 0 and 1 dose of HABV at month 6; subjects in group 3 each received 2 doses of HABV with a 6-month interval (at day 0 and month 6).

Eligibility Criteria:
Inclusion Criteria:

* Healthy infants between 18 and 24 months old;
* Have not received hepatitis A vaccine before;
* Completed hepatitis B vaccine full immunization schedule;
* Written consent of the guardian of each participant;

Exclusion Criteria of the First Injection:

* History of allergy to vaccine(s), or history of serious adverse reaction to vaccination, such as urticaria, dyspnea, angioneurotic edema, or abdominal pain;
* Autoimmune disease or immunodeficiency;
* Any acute disease that made the conditions of the person unsuitable for vaccination
* Administration of any live attenuated vaccine within 14 days prior to the injection;
* Administration of any subunit vaccine or inactivated vaccine within 7 days prior to the injection;
* Administration of treatment of immunosuppressants (e.g., corticosteroid) within 1 month prior to the injection, or planning for such treatment during this study;
* Body temperature \> 37.0 °C before injection;
* Based on the evaluation of the investigator, there was any other factor that indicating the person was unsuitable for this study;

Exclusion Criteria of the Second Injection:

* Any acute infectious disease, body temperature \> 38.5 °C or acute attacks of chronic diseases within 3 days prior to the second injection;
* Administration of blood product or other investigational drug during this study;
* Occurrence of adverse event at grade 3 or higher and the event was related to the first injection;
* The investigator or the Ethic Committee decided that the subject should be excluded;