cyrilzakka/clinical-trials huggingface dataset:
Evaluation of a Personalized Care Management Program for High Hospital Utilizers

This randomized clinical trial intends to evaluate the effectiveness of enrollment in Atrium Health's Multiple Visit Patient (MVP) care management program compared to usual care on reducing 12-month total inpatient hospital utilization among patients with high past volume of hospital inpatient stays.

The list of patients with four or more inpatient hospital visits in 2019 will be pulled from the Atrium Health electronic data warehouse (EDW) by IAS Clinical Quality Analytics, and eligibility for the MVP program of patients on this list will be determined by the Population Health's Care Management team based on predefined eligibility criteria. IAS CORE will randomize eligible participants into one of two groups: 1) MVP program; or 2) usual care.

Population Health's Multiple Visit Patient (MVP) care management program aims to manage health and lower hospital utilization among patients with a history of high inpatient hospital stays at Atrium Health. Patients eligible for the program have four or more inpatient visits over the 12-month period prior to enrollment. Once enrolled, each MVP program participant receives on-going support from an assigned MVP care manager and larger care management team, including the following core program components:

1. customized care plan developed for each patient at the time of enrollment
2. routine, virtual health monitoring and collaborative care management team-based review
3. personalized navigation and coordination across multidisciplinary Atrium Health services, as needed
4. education, health coaching, and support via telephonic and in-person interactions, as needed

The control group will receive usual care.

Upon completion of the 12-month period during which outcomes data will be accrued, the study will evaluate whether 12-month participation in the MVP program care management program, compared to usual care, reduced inpatient hospital use.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* 4 or more inpatient hospital visits across Atrium Health Metro hospitals in 2019

Exclusion Criteria:

* Existing MVP participants
* Patients who at the time of identification for the MVP program are:
* Actively enrolled in a Levine Cancer Institute oncology navigation program
* Actively receiving hospice or palliative care
* Attributed to a primary care provider at an outside healthcare system
* Patients whose primary residence is a skilled nursing facility
Clinical Concordance Study Between Watson for Oncology and Clinician Practice

At present, Watson for Oncology has been applied in 14 countries worldwide, including China, the United States, Holland, Thailand, India, Korea, Poland, Slovakia and Bangladesh. In a double-blind study involving 362 patients in India, treatment recommendations from Watson for Oncology (WFO) performed a high degree of consistency with their multidisciplinary tumor board. The investigators would recruit cancer patients diagnosed as lung cancer, breast cancer, gastric cancer, colon cancer， rectal cancer，cervical cancer or ovarian cancer according to the criteria of Watson for Oncology ，using the updated version of Watson for Oncology to explore the concordance of therapeutic regimen between WFO and physicians in the Affiliated Hospital of Qingdao University.

This study was approved by the Affiliated Hospital of Qingdao University ethics committee.The investigators would randomly selected cancer patients, including lung cancer, breast cancer, gastric cancer, colon cancer，rectal cancer，cervical cancer and ovarian cancer patients, from the Affiliated Hospital of Qingdao University database according to the criteria of Watson for Oncology(supplementary materials). Case data would be extracted and input into the Watson system. WFO provided therapeutic recommendations in three categories: recommended, for consideration, and not recommended. Data would be analyzed retrospectively to compare the WFO's recommendations and actual therapeutic regimen in the hospital. Some actual regimen applications that were not available in WFO will be defined as "physician's choice". Overall, physician's recommendations would be defined as concordant with WFO if they corresponded to the recommended or consideration categories and as non-concordant if they corresponded to the not recommended or not available categories.

Eligibility Criteria:
Inclusion Criteria:

* a histology of lung cancer,breast cancer,gastric cancer, colon cancer， rectal cancer，cervical cancer and ovarian cancer
* had no prior systemic therapy and need neoadjuvant/adjuvant or metastatic therapy
* had prior neoadjuvant therapy, adjuvant therapy and/or surgery and are now metastatic
* have had prior surgery and now need adjuvant therapy
* seeking an additional therapy whose cancer has progressed beyond its initial metastatic therapy (second line)

Exclusion Criteria:

* not have confirmed diagnoses of invasive cancer
* under 18 years of age
* pregnant
* with multiple concurrent primary cancers or a local recurrence or a new primary at the same site of a previously treated cancer
Effect of Cyanoacrylate and Concentrated Growth Factor on Palatal Donor Site

The aim of this planned randomized controlled clinical study is to evaluate the morbidity of the palatal donor area after free gingival graft (FGG) operations. In this study, wound healing and pain levels in the palatal region will be evaluated after cyanoacrylate and concentrated growth factor (CGF) applications.

Free gingival graft obtained in the palatal region causes morbidity. Therefore, clinicians try to overcome these difficulties by isolating the wound in the palatal region from the oral environment and/or accelerating wound healing.

Periodontal dressings, acrylic stents, hemostatic agents, surgical sponges, platelet concentrates, low-level laser therapy, photobiomodulation, cyanoacrylate tissue adhesives and hyaluronic acid are some of the methods used for donor site management or to accelerate healing.

Cyanoacrylate adhesives form an adhesive film through rapid polymerization triggered by the hydroxyl groups on the surfaces to which they are applied. They have both bacteriostatic and hemostatic properties.

In recent years, it has been observed that the use of platelet concentrates such as Platelet Rich Plasma (PRP), Platelet Rich Fibrin (PRF) and autogenous products such as CGF (concentrated growth factor) in periodontal treatments has increased.

CGF is obtained by centrifuging blood in four different cycles and times. This product contains a relatively intact fibrin clot containing platelets, leukocytes, various growth factors and cytokines. CGF can be applied as a carrier of growth factors and/or a barrier membrane to aid tissue regeneration and wound healing in clinical applications.

The aim of this planned randomized controlled clinical study is to evaluate the morbidity of the palatal donor area after FGG operations. In this study, wound healing and pain levels in the palatal region will be evaluated after cyanoacrylate and CGF applications.

Eligibility Criteria:
Inclusion Criteria:

* systemically healthy
* not had periodontal surgery in the last 6 months

Exclusion Criteria:

* smoker
* allergic to medication
* high anxiety (using modified dental anxiety scale)
Home-based Exercise Via a Telecommunications System

This study is investigating the effects of a home-based resistance exercise program, administered via an interactive telecommunications system, in functionally limited older veterans.

Inactivity and a sedentary lifestyle have been shown to accelerate and exaggerate the age-related decline in muscle strength. In this context, a rapid decline in strength among older adults has been linked to physical frailty, falls, functional decline, impaired mobility, and nursing home placement. Substantial evidence now suggests that habitual physical activity is associated with the maintenance of muscle strength and physical function well into the 8th and 9th decades of life. We propose to investigate the effects of a home-based resistance exercise program, administered via an interactive telecommunications system without the participation of health professionals, in functionally limited older veterans. Subjects will be randomized to either the automated exercise group or an attention placebo control group. The exercise group will undergo resistance training at home three times a week for 6 months, guided by the telecommunications system, followed by a 6-month maintenance phase of less frequent interaction with the system. Outcome measurements will include muscle strength and physical performance related to daily activities at 3, 6, and 12 months to determine the efficacy of the intervention and the time course and durability of the effect. The control group will also interact with the telecommunications system once a week for the whole year, but no exercise will be prescribed. If this home-based, automated, interactive exercise program is effective, it will provide a low-cost easily disseminated approach to improving the strength and functional status of older veterans

Eligibility Criteria:
Inclusion Criteria:

* Age 65 years
* Ability to use a telephone without assistance

Exclusion Criteria:

* Angina pectoris
* Myocardial infarction
* Ventricular dysrhythmia currently receiving therapy
* Systolic blood pressure 165 mm Hg or diastolic blood pressure 100 mm Hg
An Educational Intervention on Provider Knowledge for the Support of Cancer Survivors

This clinical trial utilizes the Project Extension for Community Healthcare Outcomes (ECHO) model to recruit, train, and support community healthcare providers in cancer survivorship best practices. Cancer survivors have distinct medical needs and are more likely to report being in poor or fair overall health compared to those who do not report a history of cancer. There is a lack of educational opportunities focused on survivorship care for health providers. Although progress has been made with the development of survivorship guidelines, physicians continue to express barriers to addressing concerns of cancer survivors. This study is to utilize a Survivorship ECHO education intervention to assess its effects on provider knowledge and comfort with survivorship guidelines as well as greater adherence to guideline concordant breast cancer survivorship care recommendations.

PRIMARY OBJECTIVES:

I. Determine the effectiveness of the Survivorship ECHO's platform by assessing provider knowledge of cancer survivorship best practices using pre- and post-enrollment surveys.

II. Evaluate implementation of survivorship best practices into clinical practice and documentation after enrollment in our Survivorship ECHO.

OUTLINE:

Participants attend 6 sessions of Survivorship ECHO educational intervention over 1 hour each, every 2 weeks for 12 weeks. Participants may optionally participate in a one-on-one interview to give feedback about the sessions over 30 minutes.

Eligibility Criteria:
Inclusion Criteria:

* Providers from The James Cancer Network (consists of five community sites in Ohio: St. Rita's Memorial Center, Memorial Health, Madison Health, Wooster Community Hospital, and Clinton Memorial Hospital)
* Eligible participants will include registered nurses, advanced practice registered nurses, physician assistants, nutritionists, radiation oncologists and oncologists
Diagnostic Accuracy of Doppler Ultrasound and Role of Uterine Artery Doppler

This study will be conducted on (100) pregnant women diagnosed as placenta previa by ultrasonography and are candidates for either emergency or elective repeated cesarean section or hysterectomy (if the diagnosis of placenta accreta is confirmed).

All of those patients are presenting during the period of may 2018 to july 2018 to Kasr-Al Ainy Obstetrics outpatient clinic or casualty department during their 3rd trimester.

All of them will be assorted according to certain inclusion and exclusion criterions as follow:

This study will be conducted on (100) pregnant women diagnosed as placenta previa by ultrasonography and are candidates for either emergency or elective repeated cesarean section or hysterectomy (if the diagnosis of placenta accreta is confirmed).

Those patients are attending to Kasr-Al Ainy Obstetrics outpatient clinic or casualty department during their 3rd trimester.

Ultrasound and doppler will be done to all patients to diagnose placenta accreta . The diagnosis will be confirmed by intraoperative assessments and histopathological examination of the uterus after cesarean hysterectomy

Eligibility Criteria:
Criteria:Inclusion Criteria

* Gestational age more than 28 weeks
* Single living fetus.
* One or more cesarean section or hysterotomy.
* Placenta previa (all grades) with high possibility of morbidly adherent placenta accreta (all types).

Exclusion Criteria:

* Maternal chronic medical disorder (diabetes mellitus or hypertension).
* Pregnancy induced disorders (pre-eclampsia or gestational diabetes).
* Associated fetal anomalies.
An Evaluation of a Psychoeducation Program in Individuals Diagnosed With Schizophrenia

This study was conducted to explore the effect on social functionality of the psychoeducation program organized to guide individuals diagnosed with schizophrenia to identifying and recognize emotions in facial expressions. half of participants were assessed the psychoeducation program. other half of participants were used only measurement tests.

The difficulties those diagnosed with schizophrenia have with facial identification and identifying emotions are closely associated with the adverse symptoms of the illness. Those diagnosed with schizophrenia need to be helped in forming interpersonal relations so that they can gain the skills needed to live in society.

ın this study the investigators prepared a psychoeducation program for individuals diagnosed with schizophrenia. The program titled, "Psychoeducation Program for Emotion Identification and Expression in Those Diagnosed with Schizophrenia" was conducted with the patients in the intervention groups once a week for ten weeks. On the other hand there were a control group which weren't be applied any intervention. The investigators applied some tests to intervention and control group three times ( before intervention, after intervention and three months after intervention). This study was conducted at three Community Mental Health Centers (CMHC's). The patients who met the study inclusion criterias were determined in these centers. Randomized psychoeducation and control groups were formed from these patients.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of schizophrenia according to DSM-IV
* over the age of 18

Exclusion Criteria:

* having cominication problems
* having another psychiatric disease
Effect of Rhythmic Gymnastics Training in Children With Down Syndrome

Some of the clinical characteristics of people with Down syndrome (DS) are orthopedic, cardiovascular, neuromuscular, visual, cognitive and perceptual disorders, which directly affect the quality of their movements. Children with DS often have a sedentary lifestyle or low levels of physical activity which exacerbates problems related to obesity and overall physical health. Therefore, the practice of physical exercise in this type of population is essential to improve their health-related physical fitness. The aim of this study was to analyze the influence of an adapted rhythmic gymnastics training program on body composition, tendon architecture and stiffness, and physical capacity in children with DS.

Children with DS with medium to moderate intellectual disabilities are required to participate. Participants will complete 10 weeks of training, two days per week. They will be divided into two groups: the Control Group will receive two swimming sessions per week and the Experimental Group will receive two swimming sessions plus two rhythmic gymnastics sessions. Before and after the application of the program, the following will be evaluated: body composition by Inbody 720, muscular architecture and elastography by Logiq® S8 ultrasound scanner and tendon stiffness by Myoton® Pro portable myotonometer. The tendons to be studied will be the Achilles tendon and the patellar tendon.

Eligibility Criteria:
Inclusion Criteria:

* Disabiluty: mild to moderate

Exclusion Criteria:

* Any contraindication to exercise
* Severe or profound intellectual disability
* Musculoskeletal disorders that prevented completion of the tests
Low Dose Thymoglobulin to Protect Kidney Function After Liver Transplant

This study will evaluate the use of a drug called Thymoglobulin, combined with a delayed start of the anti-rejection drugs (10 days after liver transplant), compared to the current approach of starting anti-rejection drugs called calcineurin inhibitors or CNI's within 2 days after the liver transplant.

Strong anti-rejection drugs like tacrolimus or cyclosporine, are given to patients who have received transplants, to ensure that the patient's body does not reject the new organ. In some cases, while anti-rejection medications protect a newly transplanted liver, they can injure the patient's kidneys and cause them not to work as well as they should. The purpose of this pilot study is to determine the best way to protect kidney function and to ensure that the newly transplanted liver is not rejected. This study will evaluate the use of a drug called Thymoglobulin, combined with a delayed start of the anti-rejection drugs (10 days after liver transplant), compared to the current approach of starting anti-rejection drugs called calcineurin inhibitors or CNI's within 2 days after the liver transplant.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing deceased donor solitary liver transplantation
* Adults aged 18-70 at time of transplantation
* Hepatocellular carcinoma as indication for OLT within the Milan Criteria
* Hepatitis C positive or negative patients
* Willingness to comply with study procedures
* Able to sign informed consent

Exclusion Criteria:

* Prior kidney transplantation
* Congenital or iatrogenic absence of one kidney
* Subjects on renal replacement therapy at the time of OLT
* MELD score \> 28
* HIV positive patient
* Patient with current severe systemic infection
* History of bacterial peritonitis within 30 days prior to OLT
* Active infection or recent infection within 30 days prior to OLT
* Use of calcineurin inhibitor continuously for more than 90 days within the past 6 months
* History of hypersensitivity to thymoglobulin, rabbits, tacrolimus or iohexol
* Women of childbearing age who are unwilling to use effective contraceptive methods during the duration of the study
Full Occlusal Rehabilitation for Patients With Severe Tooth Wear Using Indirect Composite Restorations

LAVA Ultimate composite restorations will be used as restorative material to reconstruct severely worn dentitions.

Standard dental treatment will be provided to the patients with severely worn dentitions. Treatment is based on the principles of 'minimally invasive treatment techniques'.

Main difference with the 'standard' treatment protocol and the standard procedure of placing composite restorations is the fully digital workflow. In the traditional workflow a silicon impression is made, after which the dental technician produces the (indirect) composite restorations in by hand. These restorations are then adhesively cemented on the teeth by the dentist. In the fully digital workflow, digital 3D-scans are made using the 3D LAVA scanner (3M ESPE). Based on these digital 3D-images a digital wax-up is made by the dental technician after which all composite restorations (uplays and backings) are designed digitally before being milled and finally adhesively cemented on the teeth by the dentists. An important benefit for the patients is the rehabilitation of their worn dentitions. Functionality (teeth are less sensitive, improved chewing ability, a better occlusal stability, etc) and aesthetics will be improved immediately after finishing the treatment. Moreover, the estimated treatment time will be less (estimated treatment time approx. 12hours) than the traditional methods when using the standard treatment protocol (estimated treatment time approx. 18hours).

Another potential benefit is a better control and more predictable results by using 3D-images with the pre-designed computer simulation.

A risk of these indirect composite resin restorations is the unknown survival rate compared to other indirect as well as to direct application technique

Eligibility Criteria:
Inclusion Criteria:

* Generalized severe tooth wear
* Presence of functional problems
* Necessary increase of vertical dimension of occlusion (VDO) of ≥3 mm at location of first molars
* No edentulous space in need for treatment in the anterior region in upper and lower jaw
* A minimum of three posterior teeth (premolars and molars) per quadrant

Exclusion Criteria:

* ASA 4
* Functional problems (mouth opening \< 5cm, severe Tempero Mandibular Dysfunction)
* Severe periodontitis (DPSI = 4)
Circulating Cathodic Antigen Test Compared to Microscopy for Diagnosis of Urinary Schistosomiasis in Sohag

Schistosomiasis is a chronic infection endemic in 74 tropical and sub-tropical countries. Sub-Saharan Africa carries the highest burden (90%) of schistosomiasis which caused by both Schistosoma mansoni and Schistosoma haematobium. The prevalence of Schistosomiasis should be assessed to control of the infection. This is usually achieved through surveys based on the use of traditional parasitological methods as urine filtration for S. haematobium. However, these traditional methods are time consuming, require an experienced technician and multiple samples due to light-infection and irregular shedding. Therefore, the point-of-care Circulating Cathodic Antigen (POC-CCA) urine test has been developed for the diagnosis of S. haematobium infection which is simple, rapid, sensitive and specific assay.


Eligibility Criteria:
Inclusion Criteria:

* 100 outpatient children aged between 5 - 16 years

Exclusion Criteria:

* Outpatient children should not have received schistosomiasis treatment (within the past 6 months) prior to the study