cyrilzakka/clinical-trials huggingface dataset:
Analysis of the Reservoir in Individuals Controlling HIV Infection

The aim of this study is the gain new insights into HIV latency in HIV controllers through extensive blood an tissue sampling (lymph node, colon biopsies, placenta) from 25 individuals living with HIV and healthy individuals.


Eligibility Criteria:
Inclusion Criteria:

* Elite Controllers: pVL\<50 copies per ml for at least 12 months, treatment naive at the time of inclusion
* Viral controllers: pVL \<2000 copies/ml; CD4\>500/µL for at least two years, treatment naïve at the time of inclusion
* Long-term non-progressors: CD4\>500/µL, pVL \<10000 copies/ml, for at least 7 years, treatment naïve at the time of inclusion
* Post treatment controllers: on cART for at least 12 months; pVL \<500 copies/ml for at least 2 years after treatment cessation .
* PLWH who received bone marrow transplant: people living with HIV who received a bone-marrow transplant for non-HIV related reasons

Exclusion Criteria:

* Current history of opportunistic infection (AIDS defining events as defined in category C of the CDC clinical classification), consisting of chronic HIV-1 infection.
* Evidence of active HBV infection (Hepatitis B surface antigen positive or HBV viral load positive in the past and no evidence of subsequent seroconversion (= HBV antigen or viral load negative and positive HBV surface antibody)).
* Evidence of active HCV infection (HCV antibody positive result within 60 days prior to study entry with positive HCV viral load or, if the HCV antibody result is negative, a positive HCV RNA result within 60 days prior to study entry).
* Current or known history of cardiomyopathy or significant ischemic or cerebrovascular disease.
* Current history of cancer.
* History of HIV-related thrombocytopenia.
* Any condition, including preexisting psychiatric and psychological disorders, which will in the opinion of the investigator interfere with the trial conduct or safety of the participant.
* Abnormal results of standard of care laboratory tests:

  1. Confirmed haemoglobin \<11g/dl for women and \<12 g/dl for men
  2. Confirmed platelet count \<100 000/µl \*
  3. Confirmed neutrophil count \<1000/μl
  4. Confirmed AST and/or ALT \>10xULN
* Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
* Acute or serious illness, in the opinion of the site investigator, requiring systemic treatment and/or hospitalization within 60 days prior to entry.
* The following treatment will be prohibited three months before screening and during the study:

  1. immunosuppressive drugs (inclusive corticosteroids) except for drugs used for topical use.
  2. Immunomodulatory drugs including but not limited to Granulocyte-colony stimulating factors, Granulocyte-monocyte colony-stimulating factor, interleukin 2, 7 \& 15.
Bioequivalence Study of Bosentan 125 mg Tablets Immediate Release (IR) Versus Tracleer® 125 mg Tablets IR In Healthy Subjects

Bioequivalence Study of 2 formulation of bosentan (Bosentan GEROPHARM vers. Tracleer® Actelion)

Study to evaluate the bioequivalence of orally administered bosentan preparations, immediate release tablets, 125 mg in normal healthy subjects under fasting conditions

Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent form.
* Healthy male aged 18 to 45 years.
* Verified diagnosis is "healthy" according to data Standard clinical, laboratory and Instrumental methods of examination.
* Have a body mass index between 18,5 and 30 kg/m2.
* Subjects must use, with their partner, methods of highly effective contraception throughout the study and 30 days after the end of study.
* Ability to keep fasting state for at least 14 hours.
* Consent and ability to respect the schedule of visits and the points of the Protocol.

Exclusion Criteria:

* History of serious allergic problems/events.
* Medicinal intolerance.
* Any acute and chronic diseases of the cardiovascular system, cardiovascular, bronchopulmonary, neuroendocrine systems, as well as diseases of the gastrointestinal tract, liver, kidneys, blood.
* Psychiatric disorders, history of epilepsy and seizures.
* Acute infectious diseases in less than 4 weeks before the start of the study.
* Subjects who have taken medication 2 weeks preceding before the study.
* Subjects who have taken any drugs known effects on hemodynamics or to induce or inhibit hepatic drug metabolism within 30 days prior to administration of the study medication (examples of inducers: barbiturates, omeprazole, etc.).
* Donation of plasma (450 mL or more) within 2 month prior to administration of the study medication.
* History of significant alcohol or drugs abuse or any indication of the regular use of more than 10 units of alcohol per week (1 Unit = 200 mL of wine or 500 mL of beer or 50 mL of alcohol 40%).
* Smokers.
* Participation in other clinical training is less than than for 3 months before the study.
* Lack of signed informed consent form.
* 10% deviation from references in lab tests.
* Positive testing for alcohol, drugs.
* Dehydration due to diarrhea, vomiting, or other causes within the last 24 hours before the start of the study.
* Any diet (vegetarian, etc.) extreme physical exercise, night shift work.
* Heart rate below 60 or above 80 beats per minute.
* Systolic blood pressure less than 110 mm Hg or more than 139 mm Hg.
* Diastolic blood pressure less than 60 mm Hg or more than 89 mm Hg.
* Volunteers, for Investigator opinion, who can not understand and evaluate the information about this study.
Prospective Cohort for Adult Hemophagocytosis

This prospective study enrolls subjects who have clinical and laboratory manifestations related with hemophagocytic lymphohistiocytosis. The purpose of the study is to evaluate clinical and biological features of adult hemophagocytic lymphohistiocytosis. The enrolled subjects into this study will be evaluated according to the HLH (hemophagocytic lymphohistiocytosis)criteria and treated with systemic immunosuppressive therapy or chemotherapy. All subjects will be regularly monitored by physicians participating in this study.

Study process is as follows.

1. Informed consent for subjects fulfilling the inclusion criteria.
2. Laboratory evaluation will be done for subjects according to the following diagnostic criteria.

   * Diagnosis will be established if one of either 1 or 2 below is fulfilled

     1. A molecular diagnosis consistent with HLH
     2. Diagnostic criteria for HLH fulfilled (5 out of 8 criteria below)
   * fever ≥ 38.5'C for ≥ 7 days
   * splenomegaly ≥ 3 finger breadth below left subcostal margin
   * cytopenias affecting ≥2 of 3 lineages in peripheral blood (Hemoglobin \< 9 g/L, Platelets \< 100 × 109/L, Absolute neutrophil count \< 1.0 × 109/L)
   * Hypertriglyceridemia and/or hypofibrinogenemia: Fasting triglycerides ≥ 265 mg/dL, fibrinogen ≤ 1.5 g/L
   * Hemophagocytosis in bone marrow or spleen or lymph node
   * Low or absent NK-cell activity (according to local laboratory reference)
   * Ferritin ≥ 500 mcg/L
   * Soluble CD25 (sIL-2 receptor) ≥ 2,400 U/mL

Eligibility Criteria:
Inclusion Criteria:

* Subjects should fulfill the following criteria

  1. Subjects should have at least one of the following problems

     1. Presence of hemophagocytosis in tissue or bone marrow
     2. Presence of at least 3 conditions among 8 conditions of HLH diagnostic criteria
  2. Age \> 18 years
  3. Written informed consents

     Exclusion Criteria:
* Subjects cannot satisfy the inclusion criteria
Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT

Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured in order to describe impact of PE evacuation on aeration and ventilation of the lungs.

Critically ill patients treated in intensive care units have a disorder of distribution and volume of body fluids due to principal illness and some therapeutic interventions. One of its manifestations is pleural effusion (PE) formation.

Patients on mechanical ventilation indicated by treating physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured. The purpose of the study is to better understand impact of PE evacuation on aeration and ventilation of the lungs.

Eligibility Criteria:
Inclusion Criteria:

* mechanical ventilation, presence of pleural effusion, decision of the treating physician to drain it

Exclusion Criteria:

* impossibility to apply EIT belt or to find suitable save point for drainage when the EIT belt is attached
* standard EIT exclusion criteria according to the device manufacturer
Gamete Donation Conception and Disclosure to Children : Towards an Evaluation of the Practices (AMP)

Assisted reproductive techniques (ART) is very framed in France by principles initially stated by the french CECOS Federation of (Centre d'Etude et de Conservation des Oeufs et du Sperme) and then included in the bioethic law. Since 1973, more than 50 000 births have been achieved through sperm donation, and the investigators have little knowledge of what information parents pass on to their children about how they have conceived. However, it is accepted that the secrecy about the use of donated gametes has negative consequences.

The investigators propose an original project never initiated in France, to evaluate at the national level the disclosure to the people conceived using donated gametes, thanks to an interdisciplinary research crossing medical approach (biology, psychology) and social sciences (anthropology, sociology). It uses a quantitave and qualitative approach relying on one hand on online questionnaires and on the other hand on semi-structured interviews, aimed at parent who have used ART with donated gametes and people conceived using donated gametes. This dual approach will outline broad trends in sharing information about the use of donated gametes, explore in depth the motivation of parental choices for information, and better understand the family and biographical dynamics associated with information sharing or its absence. Moreover, this project will lead to evaluate the way in which the parents received the messages of the professionnals involved in ART with donation gametes, in terms of disclosure to offspring.

The conclusions will highlight the most important elements that will be useful to the professionnals involved in gamete donation to help them improve their practices upstream, during, and after the completion of the ART with gamete donation.


Eligibility Criteria:
Inclusion Criteria:

For the parents :

* Parents of children from sperm donation
* Parents of children from oocyte donation
* Major people
* Parents who have benefited from taking over in France or taking charge in a foreign country, in a legal framework different from ours
* People who gave their non-opposition

For the childs :

* Person born by sperm donation
* Person born by Egg donation
* Major person
* Person who gave their non-opposition

Exclusion Criteria:

* Minor person
* No one who has used the amp or anyone who is not from an amp with gamete donation.
* People who have not expressed their non-opposition
The Relationship Between Breastfeeding During Early Pregnancy and Miscarriage

Breastfeeding provides various health and psychological benefits to mothers and their babies. It also acts as an effective method of natural contraception when applied strictly for up to six months after birth. Studies show that breastfeeding times are getting longer in the USA and more babies are breastfed for more than 12 months compared to the past. Recent research shows that 57% of US infants are breastfed until at least six months of age, and more than a third continue to be breastfed for up to 12 months. Prolonged breastfeeding durations increase the prevalence of breastfeeding during pregnancy, especially with the shortening of the intervals between pregnancies. Breastfeeding during pregnancy is a relatively common practice in many parts of the world. According to the data of studies conducted in low- and middle-income countries, it has been determined that 35% of the last born babies continue to be breastfed in the next pregnancy of their mothers. It has also been shown that the prevalence of breastfeeding during pregnancy in low-income countries is between 15% and 50%. Few research has been done on the relationship between breastfeeding during pregnancy and maternal, infant, or pregnancy outcomes. Some studies have suggested that hormonal mechanisms in pregnancy may link breastfeeding during pregnancy and abortion. When babies stimulate the nipple and areola during sucking, they trigger the release of oxytocin in the mother, causing a series of reactions that push the milk towards the nipple. We know that the prevalence of short and long breastfeeding intervals in pregnancy is high in our country. Therefore, in this study, we are planning to investigate whether there is a relationship between breastfeeding during pregnancy and miscarriage based on this information.

Our aim in this study is to investigate whether breastfeeding during pregnancy increases the risk of abortion and to determine whether there is a relationship between them. For this purpose, approximately 76 pregnant women who were pregnant and continuing to breastfeed in Siirt Training and Research Hospital between June 2022 and December 2022 will be included in the study. The same number (n:76) non-breastfeeding pregnant control group will be included in the study. Age, gestational week, pregnancy history (gravida, parity, abortion, missed, ectopic),breastfeeding time in previous pregnancies, bleeding, daily breastfeeding frequency and medical history of the pregnant will be recorded. In the light of the information obtained in this way, we plan to determine whether there is a relationship between breastfeeding during pregnancy and abortion.

Eligibility Criteria:
Inclusion Criteria:

* being breastfeeding
* being at the 1.st trimester of pregnancy

Exclusion Criteria:

* history of inherited thrombophilia
* history of uterine anomaly
* history of trauma
* history of genetic anomaly
* history of habitual abortus
Effects of Whole-Body Vibration on Balance in the Elderly Population

The goal of this pilot study is to test whether in the elderly population there are acute long-term improvements in both the static and dynamic balance, reaction time and mobility with the use of WBV.

Exercise therapy plays an important role in health promotion, preservation of physical function and in preventing loss of independence among the elderly. They work beside an improvement in balance, a positive effect on metabolic and cardiovascular disorders, reducing falls, osteoporosis, colon cancer, breast cancer, depression, anxiety, and the general well-being. There is preliminary evidence to indicated that balance, and strength can be trained in the elderly using whole-body vibration (WBV) therapy. The use of WBV in the elderly population has shown to be a simple and effective treatment in the areas of balance and mobility. It would be very desirable to investigate these factors further in order to provide evidence for the delivery of sustainability of training methods.

Eligibility Criteria:
Inclusion Criteria:

* BESA to include performance level 0,1,2.
* live in the senior residence Multengut Muri or in the canton of Bern.
* apart from the complaints of old age healthy and can stand with or without aids.
* more than 22 points at the Mini-Mental State Examination

Exclusion Criteria:

* Seniors / graduates may no severe, uncorrected visual disturbances (eg, low vision, double vision, skew deviation).
* Acute stress the incompatibility of the lower limb / hip / ridge during the SRT: joint disease, thrombosis, fresh fractures, infections, tissue damage, or fresh surgical scars.
* Seniors / inside with lower leg-/thigh prostheses.
* alcoholics.
Growth Pattern and Characteristics of Cardiac Pediatric Patients

Congenital heart disease (CHD) is the most common congenital anomaly in the body, affecting about 8 per 1000children. cardiovascular disorders are the most debilitating and one of causes of organic growth disorders in children.Malnutrition is a constant phenomenon among children with CHD. The degree and type of malnutrition may be related to characteristics of the CHD, including presence of cyanosis, congestive heart failure (CHF), or pulmonary hypertension (PHTN).

At birth, the weight and length of children with CHD are close to normal and APGAR scores are generally high. Cyanotic patients are affected in growth, depending on the severity of tissue hypoxemia and on the degree of physiological variation. Mostly acute malnutrition occurs in a cyanotic heart disease but chronic malnutrition occurs in cyanotic lesions. The severity of malnutrition variety from mild under nutrition to failure to thrive. impairing growth and increasing post-operative morbidity and mortality. Early rapid growth retardation detection in early age and improved nutritional status have the potential to reduce cardiac impact on growth and feeding. Insure appropriate nutrition in those patients by the two main methods (enteral and parenteral) help in better outcome

Eligibility Criteria:
Inclusion Criteria:

* Age: 0-4 years old
* Male and female,
* diagnosed as cardiac diseased children

Exclusion Criteria:

* children more than 4 years old
* not genetic disorder as down syndrome This is a descriptive study.
Effect of Back up Head Elevated Position on Laryngeal Visualization.

In patients with limited neck extension and mouth opening due to reasons including previous radiation therapy in the head and neck area or cervical spine pathology, tracheal intubation with direct laryngoscopy (DL) are challenging because of the difficulty in aligning the oral, pharyngeal, and laryngeal axes in order to visualize the cords. In contrast, video-laryngoscopes (VL) only require alignment of the pharyngeal and laryngeal axes, which lie along much more similar angles when compared with the oral axis. Thus, VL make tracheal intubation easier to accomplish in these patients.

Good patient positioning also maximizes the chance of successful laryngoscopy and tracheal intubation. In difficult airway society 2015 guidelines, advantages of head-up positioning and ramping, which brings the patient's sternum onto the horizontal plane of the external auditory meatus (EAM), are highlighted. In the obese patient, the 'ramped' position should be used routinely because this improves the view during DL. This position is usually achieved by placing blankets or other devices under the patient's head and shoulders, but can also be achieved simply by configuring the operation room (OR) table into a back-up head elevated (BUHE) position. Significantly improved glottic views on DL have been reported with both obese and non-obese adult patients in BUHE position. However, the effect of this simple maneuver on laryngeal visualization with the VL in patients with limited neck extension and mouth opening has not been reported.

The investigators hypothesized that BUHE position might improve laryngeal views and make intubation easier compared to the supine position with the VL in patients with simulated difficult airway (application of a cervical collar to limit mouth opening and neck movement).The investigator investigated primarily the improvement in visualization of the glottis and, secondarily, the ease of tracheal intubation after alignment of the EAM and sternal notch.


Eligibility Criteria:
Inclusion Criteria:

* patients of ASA physical status 1-2 who were scheduled for elective surgery under general anaesthesia requiring tracheal intubation

Exclusion Criteria:

* if they required rapid sequence induction; had a history of previous difficult direct laryngoscopy and required awake tracheal intubation; were unable or unwilling to provide informed consent; had uncontrolled hypertension; had a history of ischaemic heart disease without optimal control of symptoms; had a history of acute or recent stroke or myocardial infarction; had cervical spine instability or cervical myelopathy; had symptomatic asthma or reactive airway disease requiring daily pharmacological treatment for control of symptoms; or had a history of gastric reflux.
Intralesional Vitamin D Injection for Treatment of Common Warts

Researchers are trying to find out if injecting Vitamin D into a wart is an effective treatment.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients seen at the Mayo Clinic Rochester practices
* Patients suffering from one or more cutaneous warts as diagnosed by the examining physician at baseline visit on typical diagnostic characteristics
* Able to provide consent
* Both recalcitrant and non-recalcitrant warts will be included

Exclusion Criteria:

* Patients with prior use of home or office-based destructive treatments for this wart(s) in the last 1 month with salicylic acid (SA) or cryotherapy
* Immunoadjuvant therapy for warts in the last 4 months (e.g Candida)
* History of vitamin D injection of warts ever
* High-dose vitamin D supplementation (\>4,000 IU daily or equivalent) in the preceding 3 months
* Pregnancy or lactation
* Facial or genital warts
* Lesions not felt by the examining clinician to be a wart (e.g., corns or calluses)
* Immunosuppression (to include immunosuppressive medications or conditions as judged by the physician evaluating the patient at the baseline visit).
* Allergy to sesame oil
Methods for Managing Intrusive Thoughts

The current study sought to translate laboratory research on learning and memory to better understand the mechanisms and methods for implementing exposure therapy for unwanted obsessional thoughts. Specifically, we compared the processes and the short- and long-term outcomes of: (a) gradual exposure (EXP-G), emphasizing hierarchical exposure completion, versus (b) variable exposure (EXP-V), emphasizing variability in exposure intensity.

Although preliminary research suggests that learning to tolerate varying levels of fear during exposure enhances outcomes for some anxiety-related problems, no previous study has examined this possibility in the context of unwanted obsessions. Adults with a moderately distressing obsessional thought were randomly assigned to four twice-weekly sessions of either: (a) gradual exposure (EXP-G), emphasizing hierarchical exposure completion, or (b) variable exposure (EXP-V), emphasizing variability in exposure intensity.

Eligibility Criteria:
Inclusion Criteria:

* At least 18 years old
* Willing to attend and audiotape all study sessions
* Fluent in English
* Presence of one or more obsessional thoughts that cause marked distress
* If on a psychiatric medication (e.g., SSRI), willing to remain at a fixed dose while participating in the study (and stabilized on medication for 30 days before beginning the intervention).

Exclusion Criteria:

* Previous cognitive behavioral therapy (CBT) for anxiety
* Current suicidal ideation
* Current substance use disorder
* Current mania or psychosis
* Currently taking an anxiolytic (e.g., Ativan) or stimulant (e.g., Ritalin) medication
* Heart, respiratory, or neurological condition
* Current pregnancy