cyrilzakka/clinical-trials huggingface dataset:
SII And PALBI is Associated With the Prognosis of Pancreatic Cancer Surgery(SII,PALBI)

Chronic inflammation and immune dysfunction play a key role in the development of tumors. The aim of the study is to investigate the predictive value of SII and PALBI grade for the patients with pancreatic cancer surgery.

The systemic immune-inflammation index(SII), based on the counts of platelets, neutrophils, and lymphocytes,was first found to be related to the prognosis of patients in melanoma12, and was subsequently confirmed in malignant tumors such as hepatocellular carcinoma13,and lung cancer12. A retrospective multicenter cohort study showed that bilirubin levels can interfere some inflammation index'prognosis of PDAC7.The platelet-albumin-bilirubin (platelet-albumin-bilirubin, PALBI) grade as a prognostic indicator of inflammation has been found in recent years, and its role has been confirmed in patients with liver cirrhosis14,15 and hepatocellular carcinoma 16, but there is no research to verify its role in patients with pancreatic cancer. This study aims to verify the predictive value of systemic immune inflammation index (SII) and platelet-albumin-bilirubin grade (PALBI) for the prognosis of patients with pancreatic cancer surgery, and to explore the significance of other inflammatory indicators in the overall survival(OS) and disease-free survival (DFS).

Eligibility Criteria:
Inclusion Criteria:

Age ≥ 18 years old; It was diagnosed as pancreatic cancer by clinical manifestations, laboratory examination indexes, and pathology, and then surgically removed; Agree to participate in this study and sign an informed consent form;

Exclusion Criteria:

All kinds of acute or chronic inflammation, infectious diseases and blood system diseases; Metastasis of tumors in other parts; Benign pancreatic diseases such as chronic pancreatitis and autoimmune pancreatitis; Periampullary tumors without pancreatic cancer; Suspicious pancreatic cancer patients who cannot be diagnosed; Refuse to follow up.
Low-intensity Shockwave Therapy for Non-bacterial Prostatitis/Pelvic Pain Syndrome

The aim of the study is to investigate and compare the treatment efficacy and safety of ESWT vs sham treatment for CP/CPPS patients.This is a triple-blind, randomized, parallel group sham-controlled clinical study.


Eligibility Criteria:
Inclusion Criteria:

1. Participant must 18 to 60 years of age.
2. Participant has signed and dated the appropriate Informed Consent document.
3. Participant has had a clinical diagnosis of CP/CPPS defined as symptoms of discomfort or pain in the perineal or pelvic region for at least a three (3) month period within the last six (6) months

Exclusion Criteria:

1. Participant has evidence of facultative Gram negative or enterococcus with a value of ≥ 1000 CFU/ml in mid-stream urine (VB2).
2. Participant has a history of prostate, bladder or urethral cancer.
3. Participant has undergone pelvic radiation or systemic chemotherapy.
4. Participant has undergone intravesical chemotherapy.
5. Participant has unilateral orchialgia without pelvic symptoms, active urethral stricture or bladder stones, or any other urological condition associated with LUTS, any neurological disease or disorder affecting the bladder.
6. Participant has undergone prostate surgery or treatment.
7. Participant with penile or urinary sphincter implants.
8. Participant has been diagnosed with cancer during the last 5 years, or had any surgery in the pelvis.
9. Participant has a neurological impairment or psychiatric disorder preventing his understanding of consent and his ability to comply with the protocol.
10. PI-RADS score 4-5 in the baseline prostate mpMRI
11. PI-RADS score 3, PSA\>3 and age \> 40 years
12. Positive (suspicious for malignancy) DRE.
Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.


Eligibility Criteria:
Inclusion Criteria:

* age 18-100 years of age
* Patients presenting for Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities

Exclusion Criteria:

* Patients with pre-existing delirium
* Inablility to converse
Reflexology: An Intervention for Acute Myeloid Leukemia(AML) Patients

The aim of this study is to test a complementary therapy intervention (reflexology) that will assist in improving quality of life (QOL) for patients undergoing chemotherapy for acute myeloid leukemia. within the context of conventional medical care. Quality of life will be assessed via intermediate indicators: 1) physical indicators (greater physical functioning, lower presence of symptoms) 2) emotional indicators (greater spirituality, lower anxiety, and lower depressive symptomology); by a specific questionnaire. 3) chemotherapy side effects associated with the digestive system.

The goal of this study is to test a complementary therapy intervention that will assist in improving quality of life (QOL) for patients undergoing chemotherapy for acute myeloid leukemia within the context of conventional medical care. This open study will test a one group design in which participants will continue to receive conventional care. All patients will receive reflexology (a specialized foot therapy) from a certified reflexologist twice weekly from the beginning of chemotherapy treatment.

The specific aims are: 1) to evaluate the effect of reflexology treatment on chemotherapy side effects effecting the digestive system. 2) to evaluate the effect of reflexology treatment on Quality of life. The assessment of the treatment will be executed on the FACIT-D VERSION 3.The influences of the treatment will also be evaluated by the nursing staff, in order to describe the patient's mental health and the condition of his intestinal movement.The side effect before during and after the chemotherapy treatment will be compared using the questionnaire.

Eligibility Criteria:
Inclusion Criteria:

* diagnosis of AML
* chemotherapy treatment
* signing a consent form.

Exclusion Criteria:

• Not willing to sign a consent form.
Less Frequency Hemodialysis and COVID-19

Facing the unusual situation imposed by the coronavirus disease, the aim of this study is to evaluate the risk and effects of less frequent hemodialysis on prevalent patients

The novel coronavirus disease (COVID-19), also known as COVID-19 (and SARS-Cov2) by the World Health Organization, is a rapidly evolving pandemic. The outbreak is expected to infect a large portion of the world population, and a case fatality rate of 1-3% represents a significant mortality and healthcare burden. In common with other viral diseases, mortality is higher in elderly patients with high comorbidity.

The impressive figures of transmission in different communities underline the need for reorganization of efforts to limit contagion, particularly in crowded settings. Hemodialysis centres represents a specific setting in which many patients are repeatedly treated in the same area at the same time.

Dialysis patients constitute a susceptible population because of their older age, high comorbidity burden and their less efficient immune system. Therefore, they are more prone to develop severe infectious diseases than the general population.. Moreover, if infected, the requirements of specialized resources and staff is further complicated by requirements for isolation, control and prevention, putting healthcare systems under additional strain. Therefore, all measures to slow and to control unmanageably high incidence rates must be taken very seriously.

The routine treatment usually requires three dialysis sessions per week Further, some patients must travel long distances to the dialysis centre. One option to reduce the higher risk of these patients is to reduce the frequency of dialysis sessions.However, the potential benefits of reduced risk may be associated with higher interdialytic weight gain and inadequate dialysis, Two factors that increase the risk of mortality. Furthermore, the impact of reduced frequency on Anemia and Nutrition have not been extensively studied.

Eligibility Criteria:
Inclusion Criteria:

* More than 30 days of Chronic ambulatory in-center hemodialysis

Exclusion Criteria:

* More than three sessions a week
* amputated lower limbs
Exploring the Impact of Monocytes in Myeloproliferative Neoplasia (EMYNEM)

Impact of monocytes on Myeloproliferative Neoplasm hematopoietic stem cell growth and differentiation in vitro


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of MPN in the participating center
* Over 18 yo

Exclusion Criteria:

* Not able to consent
Dense Red Blood Cells in Sickle Cell Children

Quantitative and prognostic evaluation of dense red blood cells in sickle cell children: preliminary single center study from the Creteil pediatric cohort.

An association between red blood cell density and hemolytic parameters, and clinical manifestations has been demonstrated in adults with sickle cell anemia.

This factor has not been studied in children. The identification of predictive biomarkers of disease severity, especially of specific pediatric complications (cerebral vasculopathy, splenic sequestration, Dactylitis) would be useful for optimal care of the children and early intensification Red blood cell density might be one of these prognostic factors.

Eligibility Criteria:
Inclusion Criteria:

* Age: 18 months-18 years
* Patient with sickle cell disease namely SS, or S / Beta0 or S / Beta +
* Patient regularly followed in the pediatric cohort of the CHI Creteil
* Patient Hospitalized for an annual check-up
* With or without intensification by Hydroxycarbamide
* patient who haven't been transfused within 3 months
* Whose parents have given their informed consent
* Patients insured to the French social scheme

Exclusion Criteria:

* Sickle cell SC disease
* Having received an allogeneic bone marrow transplantation
* Under regular transfusion program
* Having received a transfusion within 3 months
Neurovascular Embolization Cover for Treatment of Intracranial Aneurysms and Carotid/Vertebrobasilar Fistulae

The purpose of this study is to determine whether the NEC device can effectively occlude the intracranial aneurysm or the carotid/vertebrobasilar fistula and maintain parent vessel patency

SAH (subarachnoid hemorrhage) is a devastating medical emergency. As many as 60% of patients who are afflicted die in the first 30 days as a result of the SAH, or remain severely disabled from the bleed. Existing treatment options include: medical management; endovascular therapy and surgical therapy. Endovascular techniques using detachable coils have now been refined to include stents which serve to prevent the coil mass from dislodging. Further improvement is believed to be possible with the NEC which creates a seal to exclude the aneurismal lumen from blood flow without the need for coils. This study involves the endovascular placement of the NEC across the aneurysm neck in order to treat a subset of aneurysms without coils.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of unruptured aneurysm OR ruptured aneurysm in clinically stable patients in whom coils alone are not an efficient treatment in the opinion of the investigator (i.e., large neck or fusiform aneurysm) OR direct fistulae (Type A - traumatic or aneurismal) and indirect if dural branches come from the internal carotid or vertebral artery and cannot be embolized selectively
* Subject has a confirmed diagnosis of an intracranial (including intracavernous and intrapetrous regions) sidewall saccular aneurysm or carotid vertebrobasilar fistula
* Parent artery reference diameter is \>2.5mm and \<4.5mm
* Subject is an adult above age 18
* Subject is able to provide written Informed Consent
* Subject has good general health, is clinically stable, and is considered to be mentally sound
* Subject is able and is willing to meet all expected requirements of the clinical protocol, including attending the scheduled follow-up examinations for the duration of this trial.

Exclusion Criteria:

* Subject has subarachnoid hemorrhage (SAH) \< three (3) weeks prior to NEC procedure
* Subject has had prior stenting of the target aneurysm.
* Subject is contraindicated for antiplatelet therapy,anticoagulant therapy, or radiographic contrast media.
* Subject has collagen vascular disease.
* Subject has a contraindication to angiography (e.g., serum creatinine level \> 2.5 mg/dL)
* Subject has evidence of active infection at the time of treatment
* Subject is pregnant or breastfeeding or unwilling to use birth control for duration of study
* Subject has participated in a study involving an investigational drug or device within 30 days prior to proposed entry into subject study
* Subject is unable to comply with study procedures or protocol
* Subject has co-morbid disease or condition expected to compromise survival or ability to complete follow-up assessments to 180 days
Compromised Microcirculation in Women With Polycystic Ovary Syndrome

The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.

In these studies, we propose to use the skin as a relatively non-invasive model to examine cardiovascular and endothelial function in obese women with and without PCOS. Data have indicated an important role for testosterone in influencing the peripheral microcirculation. While testosterone can lead to vasodilation in the peripheral microcirculation in both men and in women without PCOS, testosterone appears to induce vasoconstriction in women with PCOS. The differential response between women with and without PCOS, and between men and women may be the result of differential ET-1 actions in the vessel, and regulated by the receptor subtype is involved in these actions.

Eligibility Criteria:
Inclusion Criteria:

* Obese women (18-35) years with and without PCOS

Exclusion Criteria:

* Conditions that would preclude safe use of hormones
Study of the Sexual Health of Patients Treated for Breast Cancer and Followed up in the Observatory of Fertility at Jeanne de Flandre Hospital.

Study of sexual health by repeated anonymous self-administered questionnaires in patients treated for non-metastatic breast cancer and referred to Jeanne de Flandre hospital for possible preservation of their fertility. Sexual health is affected by treatments and improves after the treatments. Sexual health is influenced by multiple factors : oncology treatments received, self-esteem, body image, anxiety, depression, professional activity


Eligibility Criteria:
Inclusion Criteria:

* Female from 18 years
* In a relationship with a man or a woman
* Developing invasive carcinoma of breast cancer
* Planned medical therapy project by chemotherapy
* Followed up in the Observatory of fertility
* Patient who gave written consent to participate in the study
* Insured Social Patient
* Patient willing to follow all study procedures and duration

Exclusion Criteria:

-
Sensory Integration Therapy in a Sample of Children With Autism Spectrum Disorder

The objective of this study is to determine the effects of therapy in sensory rooms with multisensory environment on the severity of autism spectrum disorder and stereotyped and repetitive behaviours in a sample of Egyptian children with autism spectrum disorder

Autism Spectrum Disorder is a neurodevelopmental disorder characterized by deficits in social interactions, social communication and stereotyped behaviours associated with sensory disorders occurring before the age of 3.

According to DSM-5, sensory processing disorders include hyper-reactivity to sensory stimuli which is an adverse response to sensory stimuli (specific sounds or textures, excessive smells), hypo-reactivity as an apparent indifference to sensory stimuli (pain or temperature-hot/cold) and sensory seeking as a strong desire for sensory intake (touching of objects, visual fascination with lights and movements) or unusual sensory interests in the environment.\] Multisensory interactions in spatial processing are investigated with functional neuroimaging and electrophysiological recordings. Using fMRI, researchers identified candidate multisensory areas by looking for regions of cortex that are activated by visual and tactile stimuli, showing that multisensory processing in the human brain involves the multisensory areas of ''association'' cortex as well as the modality-specific areas of cortex that are specialized for the processing of stimulus features such as colour, shape and texture.

Ayres Sensory Integration therapy (ASI) is an individualized intervention designed to address the specific underlying sensory-motor issues that may be affecting children's performance during daily routines and activities, including participation within the classroom and in other contexts of the school.

Eligibility Criteria:
Inclusion Criteria:

* All patients included in the study are diagnosed with Autism spectrum disorder according to DSM-V criteria.
* Participants have to have a sensory problem in their diagnostic criteria.
* Age ranges between 3-10 years. (as scope of the study is focused on children)
* Both males and females.
* Parents or guardian agreed to informed consent.

Exclusion Criteria:

* Parents refusing to participate in the research
* Children with comorbid psychiatric and/or neurological disorder
* Children with co-morbid sensory deficit, hearing , vision, and motor deficit
* Intelligence quotient level below 60
* Children who scored typical performance in the sensory profile care-giver questionnaire
Effects of Late Dinner Against Early Dinner on Weight Loss Healthy Obese Women

The aim of the present study is to test whether late eating dinner could affect the amount of weight loss in healthy obese women in a weight-loss program.


Eligibility Criteria:
Inclusion Criteria:

* Must have Body mass index (BMI) between 27-35 kg/ m².
* Must be able to have moderate exercise.
* Must be interested to have weight loss.

Exclusion Criteria:

* Participating in a research project involving weight loss or physical activity in the previous six months.
* Pregnancy or lactation during the previous 6 months, or planned pregnancy in the next six months.
* Taking medication that could affect metabolism or change body weight.
* Report heart problems, chest pain, and cancer within the last five years.
* Smoking
* Menopause
* Diagnosis of any chronic disease such as fatty liver, cancer, chemo/radio therapy, heart disease, immune compromised conditions, abnormal thyroid hormone level.
Effect of Acarbose and Mixture of Pioglitazone and Metformin in Patients With Type 2 Diabetes

Monotherapy with DPP-IV inhibitors, SGLT-2 inhibitors or insulin secretagogues frequently failed to maintain blood glucose in patients with type 2 diabtes. It was critical to determine which was more suitable of acarbose versus metformin plus pioglitazone.


Eligibility Criteria:
Inclusion Criteria:

* Willing to participate in this present study;
* Patients with type 2 diabetes receiving stable monotherapy of DPP-IV inhibitors, SGLT-2 inhibitors or insulin secretagogues for more than 3 months;
* Screening glycated hemoglobin (HbA1c) between 7.0% and 10.0%;
* Regular diet and exercise;
* Body mass index (BMI) ≥ 18.5 kg/m2

Exclusion Criteria:

* Intolerance of metformin, pioglitazone and acarbose;
* Severe liver disease or elevated transaminases (2.5-fold the upper limit);
* Renal dysfunction or elevated creatinine (1.3-fold the upper limit);
* Systemic steroids therapy or other medication influencing cholesterol metabolism in the past 3 months;
* Infection or stress state in the past 4 weeks;
* Pregnancy or lactation;
* Patients otherwise adjudged by the investigator to be inappropriate for inclusion into the study.
Impact of Three-dimensional Visualization on Operation Strategy and Complications for Pancreatic Cancer

The aim of the multi-centre study is to evaluate correctly the impact of three dimensional visualization on operation strategy and complications for Pancreatic Cancer.

Because of the complexity of Pancreatic Cancer, the limitations of 2D images of CT/MRI and the uncertainty of surgeons'experience, it is difficult for the surgeons to diagnosis and assess the operation strategy accurately based on traditional 2D imaging(CT/MRI).The aim of the multi-centre study is to evaluate correctly the impact of three-dimensional visualization on operation strategy and complications for Pancreatic Cancer.

Eligibility Criteria:
Inclusion Criteria:

1.18 years≤ Age ≤70 years 2.Compling with the diagnosis criteria of Pancreatic Cancer. 3.Primary Pancreatic Cancer without metastasis. 4.The patients are volunteered for the study.

Exclusion Criteria:

1. Patients with mental illness.
2. Patients can't tolerate the operation owe to a variety of basic diseases (such as severe cardiopulmonary insufficiency, renal insufficiency, cachexia and blood system diseases, etc.)
3. The patients refused to take part in the study.
4. There are other co-existed malignant tumors.