cyrilzakka/clinical-trials huggingface dataset:
Attention and Achievement: A Mind Wandering Investigation

This study assesses the impact of mind-wandering on reading and math.

This study assesses the impact of mind-wandering on reading and math. Specifically 120 middle school student participants will receive descriptive measures (of achievement, attention and related factors including mind-wandering), and will receive a brief (\~30 min) lesson in reading and math (order counterbalanced). Participants will receive a brief pre-test, the lesson, and then a post-test on the reading and math outcomes. 75% of the participants will receive a brief manipulation that sets up the influence of mind-wandering, as well as redirects when probe-caught mind-wandering occurs. The remaining participants will receive only redirects, and only randomly. Among participants to receive the mind-wandering manipulation, an equal number will receive this only for reading, only for math, and for both reading and math.

Eligibility Criteria:
Inclusion Criteria:

* enrollment in schools where we have permission to conduct the study

Exclusion Criteria:

* students known to be enrolled in separate curricula (e.g., life-skills classes)
Early Palliative Care in Metastatic Lung Cancer in Northern France

Single-center, prospective, controlled, open-label, randomized, two parallel arms comparing early Palliative care versus Standard care in patients with non-small-cell metastatic lung cancer

144 patients will be included; 72 per arm.

* "Standard" Control arm: patient supported by the onco-respiratory service.
* Intervention arm: patients benefit from early palliative care in addition to standard onco-pneumologic care.

The main criterion of judgment is the TOI score measured at 12 weeks.

FACTL questionnaires, HADS and PHQ-9 will be filled out before randomization , at 12 weeks and 21 weeks

Eligibility Criteria:
Inclusion Criteria:

* Being diagnosed with non-small cell lung cancer

  * Proven histologically
  * Metastatic proven imaging (MRI, CT Scanner, PET scan)
  * Stage IV (any T, any N, M1)
* prior to secondary chemotherapy treatment.
* Age\> 18 years
* PS ≤2
* Patient able to understand the nature, purpose and methodology of the study
* signed Informed consent

Exclusion Criteria:

* Age \<18 years
* Patient already supported by palliative care
* Patient with an activating EGFR mutation or EML4-ALK rearrangement or ROS1 gene translocation
* Patient under trusteeship / guardianship
Interactive Stepping Exercise on Balance and Cognitive Function

The objective of this study is to investigate the effects of interactive stepping exercise on balance and cognitive function in individuals with PD.


Eligibility Criteria:
Inclusion Criteria:

* Idiopathic PD
* Hoehn \& Yahr stage between 1 to 3
* Age between 50 to 85
* Stable pharmacologic treatment for the last 2 weeks
* Ability to walk 10 meters unassisted or with assistive devices

Exclusion Criteria:

* Other neurological disorders diagnosis than PD
* Receiving any neurological surgeries
* Any musculoskeletal disorder or cardiopulmonary disease that may influence participation in the study
* The Mini-Mental State Examination (MMSE) \< 24 scores
* Participated in other exercise intervention of study in the past 3 months
* Colorblindness or color vision deficiency
Retention, Chewing Efficiency and Masticatory Performance of Partial Dentures Opposing Implant Retained Prosthesis.

This study aims to evaluate retention ,chewing efficiency and masticatory performance of flexible versus CAD/CAM partial dentures opposing to fixed implant retained restorations.

in this study 22 patients will be selected following inclusion and exclusion criteria. The patients will be divided randomly into two groups.

Group I patients will receive Versacrylic removable partial denture. group II patients will receive CAD/CAM removable partial denture all patients will be given the home care instructions at night and brush cleaning of the dentures.

Measurements of retention using universal testing machine, masticatory performance using T-scan III computerized system and chewing efficiency using chewing function questionnaire

Eligibility Criteria:
Inclusion Criteria:

* Non-smoker male Patients
* Age ranging from 40-50 years.
* Highly cooperative and motivated patients.
* Patients Systemically free from any immunosuppressive diseases.
* Patients free from Diabetes, Hypertension, Cancer, any mental or physical diseases.
* Patients not receiving any Radiotherapy or chemotherapy treatment.

Exclusion Criteria:

* Female patients
* Smoker patients.
* Age exceeding 50 years
* Uncooperative and unmotivated patients.
A Study of Sinotecean on Tolerance and Pharmacokinetics

This study is conducted to assess the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT), to evaluate the pharmacokinetics, safety and preliminary anti-tumor activity of Sinotecean.


Eligibility Criteria:
Inclusion Criteria:

* late malignant tumor patients diagnosed with the pathological and/or cytological;
* lack of the standard treatment or treatment failure;
* 18-65years, ECOG:0-1,expected survival period \>3 months;
* main organs function is normal;
* signed and dated informed consent

Exclusion Criteria:

* participated in other clinical trials in four weeks;
* currently under other effective treatment;
* end of anti-tumor treatment within 4 weeks(end of Nitrosourea/Mitomycin within 6 weeks);
* AE ≥ Grade 2(according to NCI-CTC 4.0),except hair loss;
* with ischemic heart disease, heart failure, severe arrhythmia, cerebrovascular disease, asthma, severe infections, active peptic ulcer;
* urine protein: ++, and urinary in 24 hours \> 1.0g;
* uncontrolled primary or metastatic brain;
* have immunodeficiency history;
* according to the researcher's judgment,there are concomitant diseases which will seriously endanger the patients or obstruct the patients to complete the clinical trial;
Anatomic Anterior Cruciate Ligament With Short Hamstring Graft Compare With a Standard Hamstring Graft Technique

this study was to evaluate the functional outcome of quadruple hamstring graft in femoral tunnel less than 15 mm and morethan or equal 15 mm of ACL reconstruction. The hypothesize that no difference intermediate follow up ( 6 month - 24 month) of functional outcome and clinical evaluation between short and normal femoral tunnel graft length of hamstring tendon ACL reconstruction.

The patient recruitment (N=29) and baseline data collection were done at our institute between March2014-September 2015. The inclusion criteria were patients with anterior cruciate ligamentous injury who needed ligamentous reconstruction, closed growth plates and younger than 60 years old, absence of ligament injury to the opposite knee. The exclusion criteria are patients who did not want to participate in this study or patient with failed anterior cruciate ligamentous reconstruction.

All the procedure of anterior cruciate ligament reconstructions were performed by the senior authors (B.C). Semitendinosus and gracilis tendons were harvested through an oblique approach medial to the tibial tubercle in all patients. Complete anterior cruciate ligament was confirmed at arthroscopy. Associated intra-articular injuries such as meniscus tear and cartilage lesions were fixed at of the index operation .The femoral tunnel were drilled though the AM portal.

Eligibility Criteria:
Inclusion Criteria:

* Patients with anterior cruciate ligamentous injury with the diagnosis of injured ligaments was made based on a detailed history of the knee injury, physical examination on pathologic status and abnormal laxity, routinely performed plain radiographs and MRI scans, and the findings at surgery.
* Patients who have closed growth plates.
* Patients who younger than 60 years old.
* Patients who absence of ligament injury to the opposite knee.

Exclusion Criteria:

* Patients with a combined ligament injury as folling:

  1. Posterior cruciate ligament
  2. The lateral collateral ligament
  3. The posterolateral corner structures of the knee
  4. Medial collateral ligament.
SENSING-AI Cohort for Long COVID Patients

The prospective study will focus on the collection of biometric and psychometric data from a limited population for 1 month with the aim of complementing the SENSING-AI retrospective cohort.

The stratification of the risk of complications related to persistent COVID symptoms both physiological and psychological in a personalized way would optimize the cost-effectiveness model for the management of these patients. Similarly, the early detection of complications associated with persistent COVID in patients belonging to vulnerable groups would improve care times and, therefore, the patient's prognosis.

The primary objective of this study is to complement the SENSING-AI cohort with biometric and psychometric data prospectively gathered from patients diagnosed with long COVID in the last year to drive the generation of AI-based risk prediction and stratification models.

Eligibility Criteria:
Inclusion Criteria:

* Legal adults
* With a long COVID-19 diagnose in the last year
* Reporting any of these symptoms:
* Fatigue
* Dyspnea
* Shortness of breath
* Anxiety
* Stress
* Depression
* Conduct disorder
* Sleep disorder

Exclusion Criteria:

* Hospital admission during follow-up due to pathology not related to COVID-19
* Patients without digital literacy or who cannot use the mobile application.
* Known severe psychiatric illness or cognitive impairment
* Being pregnant (or suspected to be pregnant)
* Discharged after hospital admission due to COVID-19
Patient Satisfaction With Postoperative Communication Modality

Communication between a surgeon and a patient in the immediate postoperative period is thought to influence patient satisfaction. There is currently no standard of care regarding the optimal form of postoperative communication, nor is there a consensus in our department as to which modality is preferred by patients.The purpose of this study is to determine which form of communication, if any, is preferred by patients. Furthermore, this study aims to evaluate the impact that various forms of communication during the immediate postoperative period have on patient (subject) satisfaction. The study hypothesizes that patient (subject) satisfaction with their surgeon will be highest among those who communicate with their surgeons via videotelephony (i.e., videoconferencing) and that the lowest satisfaction will be among patients (subjects) who did not communicate with their surgeon until their regularly scheduled postoperative office visit. The results of this study may help identify low cost methods for increasing patient satisfaction.

This is a prospective, randomized study designed to evaluate the effects of different communication modalities between surgeons and patients (subjects) in the immediate postoperative period. Given the nature of the study, it is not possible for either the surgeons or the subjects to be blinded. To reduce bias that may occur due to each surgeon's personal preference for postoperative communication modality, the surgeons (rather than individual subjects) will be randomized to one of the three communication modality groups (no communication on the day of surgery, voice call, or videoconferencing).

Eligibility Criteria:
Inclusion Criteria:

* undergoing surgery at the NYU Langone Orthopedic Center

Exclusion Criteria:

* Under the age of 18 years old
Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest

Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA). The procedure consists of two defibrillators that administer shocks at the same time.

Currently, the procedure is not initiated before at least three failed attempts with one defibrillator. This can delay the potential benefits of establishing DSED earlier in the treatment. Studies have shown that early defibrillation is crucial for survival in OHCA patients, and in 2022, a clinical trial showed that survival in patients treated with DSED was higher compared to standard treatment.

The effect of initiating OHCA treatment is unknown. The DUALDEFIB trial seeks to investigate if treating OHCA patients with DSED as an initial treatment will increase survival and provide improved neurological outcome.

The project is investigator-initiated, prospective, two-group randomized controlled trial (RCT). Prior to the RCT, a pilot feasibility trial of 3-4 months will be performed, including three ambulance bases in mid-Norway. All OHCA patients will be included until validity and feasibility of the study is accomplished. The pilot study will be followed by the RCT.

Outcome measurements in the RCT are aimed to be the same as in the pilot study. Ambulance bases will be randomized to either DSED or standard procedure for six months before crossover with the other treatment for six months.

Ambulances included in the project will carry two defibrillators. Both defibrillators will be established for initial defibrillation with DSED in OHCA patients. The pads are placed in anterior-lateral position (standard placement) and anterior-posterior position (over sternum and beneath left scapula). Shocks are administered in rapid succession with less than one second apart. All other treatment will be according to existing guidelines.

The included patients are OHCA patients with age over 18 years presenting with a shockable rhythm. Excluded patients are patients with obvious or suspected pregnancy, incarcerated patients or patients with no-resuscitation order. The patients that meet the inclusion criteria will be registered by the ambulance personnel through a secure webpage.

Primary outcome is survival to hospital admission.

Secondary outcomes are survival to hospital discharge, 30 days, 90 days and 1 year survival, in addition to neurological status.

Patients from the pilot will be included in the RCT intervention group.

Eligibility Criteria:
Inclusion Criteria:

* Patients with out of hospital cardiac arrest presenting with a shockable rhythm

Exclusion Criteria:

* Age below 18 years
* Obvious or suspected pregnancy
* Incarcerated patients
* Preexisting do-not-resuscitate order
Effect of Prebiotic Fiber- Enriched (scFOS) Enteral Feeding on the Microbiome in Neurological Injury Trauma Patients (PreFEED Microbiome Trial)

This study plans to learn more about the impact of enteral nutrition on bacteria in critically ill trauma patients with brain injury. Specifically, it seeks to understand the effect that a prebiotic containing enteral feeding formula (Nutraflora scFOS in Vital AF) has on the gut, oral, and skin bacteria. A prebiotic is a special form of dietary fiber that acts as a fertilizer for good bacteria. The prebiotic Nutraflora scFOS has been cleared by the U.S. Food and Drug Administration and is not considered investigational as used in this study. Enteral feeding is a way to give nutrition to critically ill people who are unable to eat.


Eligibility Criteria:
Inclusion Criteria:

1. Adult major neurological injury trauma patients between 18-70 years of age who have been admitted directly to trauma ICU following major trauma
2. Expected length of mechanical ventilation \> 48 hours (as judged by admitting clinician)
3. Expected length of ICU stay \> 3 days (as judged by admitting clinician)
4. Expected to survive \> 48 hours (as judged by admitting clinician)
5. Requiring enteral nutrition at any time in Intensive Care Unit (ICU) stay
6. Chronic illnesses must be under control (as determined by the Principal Investigator).

Exclusion Criteria:

1. Previous hospitalization within one month prior to ICU admission (no hospital floor transfers to eliminate confounding effect of previous hospital therapy)
2. Use of prebiotic fiber containing enteral or oral formula or probiotic preparations within one week
3. Received antibiotics within the previous month
4. On steroids or immunosuppressants at time of admission
5. All transplant patients
6. Chronic inflammatory disease that requires steroids or other biologic therapy intervention (e.g.: RA, IBD that requires steroids or Humira)
7. Undergoing active chemotherapy/radiation treatment
8. Renal failure requiring dialysis
9. Liver cirrhosis class C
Comparing Two Methods of Subacromial Space Injection

Subacromial shoulder injections can be approached from the front or side of the shoulder. The investigators are comparing both methods, to find which one has better spread in the subacromial space.

Both lateral and posterio-lateral methods of subacromial injections are widely used for diagnostic and therapeutic purposes. It is not known which method allows the most accurate access into the subacromial space and is more effective.

The investigators have been using a novel approach from the anterior aspect of the shoulder for years with good clinical effect and propose comparing this approach to the described approach. This study will indicate which method is best and will be of practical clinical importance. The investigators feel the technique is easier to perform than other described methods and could be taught to clinicians throughout the country and adopted as the standard approach.

Eligibility Criteria:
Inclusion Criteria:

* Shoulder pain for at least 6 weeks duration along the lateral aspect of the shoulder.
* Positive impingement signs.

Exclusion Criteria:

* History of compensation claim due to shoulder problems.
* Allergy to radiographic dye.
* Recent shoulder fracture.
* Bleeding disorder.
* Previous shoulder surgery.
A First Trimester Prediction Model for Large for Gestational Age Infants: a Preliminary Study

Large for gestational age infants (LGA) have increased risks of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical, biophysical, anamnestic, and clinical maternal characteristics available at first trimester.

This prospective study includes all singleton pregnancies attending the first trimester aneuploidy screening at the Obstetric Unit of the University Hospital of Modena, in Northern Italy.

For each subject, blood sample is collected in fasting conditions, then centrifuged, and the serum stored at minus 80° C, for subsequent biochemical analyses. PAPP-A, PlGF and Inibin A is measured with the automated DELFIA EXPRESS system (Thermo Fisher Scientific, Perkin Elmer ®). Insulin, high density lipoproteins (HDL) and triglycerides are measured through routine laboratory methods.

The mean arterial pressure (MAP) is measured with validated automated devices (Dinamap, BLTV6XX). After the women are seated and allowed to rest for 3-5 min, normal (22 to 32 cm) adult cuffs are fitted to their both arms. This is repeated two times with 1 min break in between. The MAP is calculated with the formula MAP DBP + 1/3(SBP - DBP) 21, where DBP represents diastolic blood pressure and SBP, systolic blood pressure. We calculate the final MAP as the average of all four measurements. Uterine artery Doppler studies including pulsatility index are measured through trans-abdominal ultrasound (Voluson E8 or Voluson E10) examinations. As indicated in Fetal Medicine Foundation (FMF), when carrying out Doppler studies, color flow mapping is used to identify each uterine artery along the side of the cervix and uterus at the level of the cervical internal os. Pulsed wave Doppler imaging is used with the sampling gate set at 2 mm to cover the whole vessel, and care is taken to ensure that the angle of insonation is less than 30°. When three to five similar consecutive waveforms are obtained, PI is measured. The uterine artery mPI is calculated by adding the right and left pulsatility index together, divided by two. All ultrasound and Doppler studies are carried out by a physician who had received the appropriate certificate of competence in the 11-13+6 week scans and Doppler study from the FMF.

Data on pregnancy outcome are collected from the hospital maternity records or directly from women if delivered elsewhere.

Medical records are reviewed by research associates to obtain anonymized data on mothers (i.e maternal demographics, BMI, age...) and their newborns (birthweight, gender, Apgar score, admission to the neonatal intensive care unit (NICU) and length of stay, neonatal morbidities, and mortality), and are organized in a password protected database.

Eligibility Criteria:
Inclusion Criteria:

* Singleton pregnancies attending the first trimester Down syndrome screening at the University Hospital of Modena, in the North of Italy (tertiary Hospital).

Exclusion Criteria:

* Twin pregnancies
* Pregnancies with major fetal abnormalities
The Effectiveness of Pharmacist-led Educational Model in Patients With Allergic Rhinitis

Allergic rhinitis is a chronic respiratory disorder affecting patients' quality of life and work performance. Pharmacists are identified as suitable professionals to deliver patient education and pharmaceutical care in managing allergic rhinitis (AR) patients. Local clinical practice guidelines in Malaysia are lacking, especially in pharmaceutical care in public healthcare institutions. This study protocol describes a randomised control trial (RCT) that aims to determine the effectiveness of a pharmacist-led educational model in managing AR (AR-PRISE Model) compared to standard pharmaceutical care. The AR-PRISE model delivers patient educational material (video) and an algorithm for pharmaceutical care.

This is a six-month, single-centre, prospective, randomised, two-arm, and parallel-group controlled trial. This trial recruits patients attending a tertiary hospital's otorhinolaryngology outpatient clinics. The participants are randomised into the control or intervention groups at 1:1 using permuted block randomisation. Each group required 77 participants. The control group will receive standard pharmaceutical care. The intervention group will receive pharmacist-led education according to the AR-PRISE model. Both groups will be assessed for the middle turbinate endoscopy findings, disease severity, knowledge level, symptom control, medication adherence, and quality of life (QoL) at baseline and end-of-study follow-up (Day 180±7). Depending on the feasibility at Day 60±7 and 120±7, they will be followed up virtually or face-to-face. During the intermediate follow-up, the participants will be assessed for symptom control, medication adherence, and QoL. The intention-to-treat analysis will include all participants assigned to each group. An Independent T-Test compares the mean difference in knowledge level between the two groups. A two-way repeated measure ANOVA analysis will be employed to determine between-group differences for scores of symptom control, adherence rate, and QoL. A one-way repeated measure ANOVA will be performed for within-group analysis. A P-value \< 0.05 is considered statistically significant.

Eligibility Criteria:
Inclusion Criteria:

* Inclusion criteria for patients include an aged 18 to 80, Malaysian, diagnosed with allergic rhinitis, and capable of reading and writing in English or Malay, who attend the otorhinolaryngology outpatient clinic at Raja Permaisuri Bainun Hospital.

Exclusion Criteria:

* Patients who are pregnant, lactating, or have a comorbid diagnosis of chronic rhinosinusitis will be excluded.
* Patients having psychiatric problems, dementia, terminal illnesses, comorbidities, post-COVID-19 conditions with symptoms that continue beyond 3 months after being infected will be excluded.