cyrilzakka/clinical-trials huggingface dataset:
Acupuncture for Anxiety in Women With Breast Cancer: A Feasibility Study

To assess the efficacy of acupuncture treatment in reducing symptoms of anxiety in women recently diagnosed with cancer.

• To assess the efficacy of acupuncture treatment on improving perceived quality of life in women recently diagnosed with cancer.

This is a feasibility study of acupuncture for anxiety reduction in women with breast cancer. Ten patients will be recruited at the UNM Cancer Research Treatment Center via the Breast Clinic and screened for anxiety. Treatment will consist of 10 acupuncture sessions over 5 weeks. Measures (Hopkins Symptom Checklist, Sheehan Disability Index) will be administered and analyzed for treatment effect on scores.

Eligibility Criteria:
Inclusion Criteria:

* Woman age 18 years or older excluding the need for parental/guardian permission.
* Histologic diagnosis of breast cancer.
* Having a minimum anxiety score of 1.75 on the Hopkins Symptom Checklist (HSCL) with sufficient English language proficiency for the investigators to make this determination.
* Able to give informed consent.
* Willingness to participate in the study and receive 10 acupuncture treatments in 5 weeks.
* Ability to fill out questionnaires and communicate with the research staff

Exclusion Criteria:

* Males with breast cancer
* Psychoses or a major personality disorder
* Current use of opiates,
Prevalence of Frailty Among People Aged 75 and Over Living at Home

The aging of population lead to study ways to prevent dependence. Frailty is a precursor to dependence which can be reversible. In the literature, estimate of prevalence of frailty is highly variable depending on the frailty definition, the population studied and the screan tool used. In fact, many scales to measure frailty have emerged without gold standard.

The SEGAm showed its usefulness in aged patients living at home.

The aim of the study is to describe prevalence of frailty in patients aged of 75 and more living at home.

Eligibility Criteria:
Inclusion Criteria:

* male or female
* aged of 75 and more
* living at home
* agreeing to participate in the study

Exclusion Criteria:

- none
Effect of Toradol on Post-operative Foot and Ankle Healing

The use of Toradol for pain control in surgical orthopedic cases is currently a topic of interest within the field. The proposed study is a prospective randomized study evaluating postoperative pain, opioid requirement, complication/reoperation rates and nonunion rates in patients undergoing surgical treatment for isolated lateral malleolar fibula fractures. Patients will be randomized to either the Treatment Group (Toradol) or the Control Group (Non-Toradol). Both Toradol and non-Toradol drug regimens are currently prescribed by the Foot and Ankle Team at the Rothman Institute and this study will serve as a valuable comparison.


Eligibility Criteria:
Inclusion Criteria:

* patients over age of 18 undergoing outpatient open reduction and internal fixation (ORIF) by a fellowship-trained foot and ankle orthopaedic surgeon for isolated lateral malleolar, bimalleolar, or trimalleolar ankle fractures.

Exclusion Criteria:

* open fracture
* allergies to one or more of the study medications
* existing use of narcotics
* renal insufficiency as defined by history and preoperative creatinine level
* pregnancy
* hospital admittance
High-dose, Short-term Steroid and Low-dose Long-term Steroid Use in ARDS Caused by COVID-19

In this study, we aimed to compare, retrospectively, the 15-day continuous hemodynamic, laboratory and clinical course of COVID 19 patients to whom we administered short-term (3 days) high-dose (1000 mg) systemic methylprednisolone with those to whom low-dose long-term (2x 40 mg) systemic methylprednisolone was administered.


Eligibility Criteria:
Inclusion Criteria:

* Between June 1, 2020 and February 1, 2021, hospitalized in the General intensive care unit of Biruni University Medical Faculty Hospital with the diagnosis of COVID 19;
* patients over 18 years of age; (for the diagnosis of COVID 19; Identification of SARS-CoV-2 by reverse transcription-polymerase chain reaction (RT-PCR) in nasopharyngeal swab or sputum samples and Abnormal lung computed tomography finding (CT) scan finding with \<90% oxygen saturation at rest (bilateral, subpleural, peripheral ground glass opacities)

Exclusion Criteria:

* Patients with a diagnosis of steroid allergy or developing during treatment;
* pregnant or lactating women;
* Patients with active malignancy;
* Patients taking any immunosuppressive agent.
Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm

The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms. Participants will be randomized to different intraoperative heparinization regimens: (i) 50 U/kg intravenous (IV) at 1-h intervals reduced by half to a minimum of 1000 u/h; (ii) 70 U/kg IV at 1-h intervals reduced by half to a minimum of 1000 u/h. MRI will be performed within 72 h after surgery, and the DWI sequence of MRI will be analyzed. If there is a comparison group: Researchers will compare different intraoperative heparinization protocol groups to see which dose of intraoperative heparin has the best prognosis for use.


Eligibility Criteria:
Inclusion Criteria:

1. Greater than 18 years old, less than 75 years old
2. Patients with unruptured intracranial aneurysm were confirmed by DSA.
3. Coagulation function should be normal in the enrolled patients.

Exclusion Criteria:

1. Dissection aneurysm, blister aneurysm, moyamoya disease or arteriovenous malformation.
2. Previous use of antithrombotic drugs (including anticoagulant or antiplatelet aggregation drugs).
The Effect of Neurolingualistik Programming (NLP) on Pain Score, Fear of Pain and Pain Catastrophizing Before Colposcopy

Colposcopy, evaluation of cervical cytological abnormalities and It is the gold standard procedure for the early diagnosis of preinvasive and invasive diseases. Despite her Essentially a minimally invasive intervention, even referring the patient to colposcopy can cause significant anxiety and distress in patients. Increased anxiety can also lead to deterioration in health-related quality. Studies have been conducted to reduce the anxiety of women undergoing colposcopy, but there are no publications on topics such as anxiety, pain perception, and pain catastrophizing.

Neuro Linguistic Programming (NLP) has been called "the art and science of personal excellence", "the study of subjective experience". NLP helps us understand the difference between our actions that produce mediocre results or failure and those that require success or excellence.

NLP: "How do I do something I do well?", "How can I do it better?", "How can I gain skills that I admire in others? It addresses questions like ". It is important to note that NLP is not limited to observable behavior. Our way of thinking, that is, all experience and It also includes the mental processes that control our actions. By dealing with the entire structure of a person's experience (in fact, their motivation), it tries to shape the thought processes, emotions and beliefs that result in a behavior. It is especially about our communication with ourselves as well as with others.

No study was planned on pain and pain perception during colposcopy by teaching the NLP technique to the patients.


Eligibility Criteria:
Inclusion Criteria:Those who are over 18 years of age and are not pregnant with an indication for colposcopy; Those who agreed to participate in the study,

Exclusion Criteria:patients who understand and can speak Turkish patients who did not meet the inclusion criteria or had previously undergone colposcopy - -
Acupressure and Stress Resilience

The current study will assess the efficacy of acupressure, a type of complementary and alternative medicine (CAM) in the Veteran population. Veterans with co-occurring mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) will be consented and randomly assigned to either an active or placebo acupressure treatment series of 8 sessions. The investigators will determine if acupressure affects aspects of day-to-day function, such as memory, sleep, mood, psychiatric health and stress resilience. This information will help identify potential treatment strategies to improve quality of life and overall function in this particular Veteran population.


Eligibility Criteria:
Inclusion Criteria:

* Between the ages of 18-60
* Diagnosis of mild TBI and PTSD as assessed by interview and/or chart review
* Currently receiving or eligible to receive physical and/or mental healthcare through the VA Eastern Colorado Health Care System

Exclusion Criteria:

* History of other significant neurological disease (e.g., Alzheimer's, Parkinson's, multiple sclerosis etc.) as assessed by interview and/or chart review. Such conditions could affect outcome measures independently, thereby creating an experimental confound.
* History or diagnosis of lifetime moderate to severe TBI, as assessed by interview and/or chart review.
* History of psychotic disorder or bipolar I disorder as assessed by structured interview. Such conditions could affect outcome measures independently, thereby creating an experimental confound.
* Inability to read the informed consent document or adequately respond to questions regarding the informed consent procedure.
* Prior experience with acupressure, as this would result in individuals potentially being able to detect Placebo treatments if randomly assigned to that group.
Serial Imaging of the Novel Radiotracer [^18F] FLuorthanatrace ([^18F] FTT) by PET/CTF

This phase I trial studies how well fluorine F 18 fluorthanatrace positron emission tomography (PET)/computed tomography (CT) works in patients with solid tumors. Fluorine F 18 fluorthanatrace is a radioactive tracer, a type of imaging agent that is labeled with a radioactive tag and injected into the body to help with imaging scans. PET/CT uses a scanner to make detailed, computerized pictures of areas inside the body. PET/CT with Fluorine F 18 fluorthanatrace may allow more tumor cells to be found in patients with ovarian, fallopian tube, or primary peritoneal cancer.

PRIMARY OBJECTIVES:

- Evaluate fluorine F 18 fluorthanatrace (\[18F\]Fluorthanatrace) positron emission tomography/computed tomography (PET/CT) as an imaging biomarker of poly \[ADP-ribose\] polymerase (PARP)-1 activity in 3 cohorts of cancer patients: 1) ovarian, fallopian tube, primary peritoneal 2) breast cancer, and 3) non-ovarian, non-breast solid tumor.

SECONDARY OBJECTIVES:

* Evaluate the safety of \[18F\]Fluorthanatrace.
* Correlate \[18F\]Fluorthanatrace uptake measures with BRCA mutation status.
* Correlate \[18F\]Fluorthanatrace uptake measures with poly \[ADP-ribose\] polymerase (PARP-1) activity in tumor tissue samples in patients who undergo biopsies.
* Evaluate change in \[18F\]Fluorthanatrace uptake measures after therapy initiation with repeat imaging before and after treatment initiation.
* To confirm the variability of imaging findings from repeated \[18F\]FTT PET/CT over 1 week before treatment initiation
* Determine the change in \[18F\]FluorThanatrace uptake before treatment initiation and at time of clinical progression
* Correlate \[18F\]FluorThanatrace uptake at time of clinical progression measures with genetic reversion mutation status

OUTLINE:

Patients receive fluorodeoxyglucose (FDG) intravenously (IV) and undergo FDG PET/CT scan over 20-30 minutes if they have not already had one per standard of care. At least 20-24 hours later, patients receive fluorine F 18 fluorthanatrace IV and undergo fluorine F 18 fluorthanatrace (\[18F\]FTT) PET/CT over 1 hour.

After completion of study treatment, patients are followed up at 24 hours.

Eligibility Criteria:
Inclusion Criteria:

* History of known or suspected solid tumor.
* At least one lesion ≥ 1.0 cm that is seen on standard imaging (e.g. computed tomography \[CT\], magnetic resonance imaging \[MRI\], ultrasound, fludeoxyglucose \[FDG\] PET/CT).

Exclusion Criteria:

* Females who are pregnant or breast feeding at the time of screening will not be eligible for this study; a urine pregnancy test will be performed in women of child-bearing potential \< 2 weeks prior to screening as standard of care.
* Inability to tolerate imaging procedures in the opinion of an investigator or treating physician.
* Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study.
Effect of Caloric Restriction and Gastric Bypass on Resting Metabolic Rate

Studies in overweight and obese subjects show a decline in resting metabolic rate (RMR) even after moderate caloric restriction. Yet the onset and course of such a metabolic adaption is still unclear. Lower resting metabolic rates were also reported after gastric banding bariatric surgery but have not yet been investigated in subjects after gastric bypass. The purpose of this study is to investigate the consequences on resting metabolic rate in subjects with obesity after moderate caloric restriction or gastric bypass.


Eligibility Criteria:
Inclusion Criteria:

* BMI ≥30 kg/m2

Exclusion Criteria:

* Marked weight reduction in the last 2 years (\>5% of initial body weight)
* Recent extreme fasting (during the last month)
* Manifest eating disorders (assignment to a specialist for eating disorders)
* Severe psychiatric disorders requiring treatment
* Pregnancy, lactation
An Observational Study to Investigate How Patients Experience the Ability to Adjust Their Asthma Maintenance Medication

An observational study to investigate how patients experience the ability to adjust their asthma maintenance medication according to instructions received from their physician. The primary aim is to create an insight in the perception of the patient when he has the ability to adjust his own maintenance treatment and how the patient exercises this in the daily practice.


Eligibility Criteria:
Inclusion Criteria:

* Inclusion Criteria: patients with prescription of budesonide/formoterol Turbuhaler 200/6 (adjustable maintenance dosing) and whom received instructions from their physician to adjust their asthma maintenance medication.
Evaluation of Fe Absorption From Iron Salt in Milk

The primary objective was:

* to compare iron absorption in apparently healthy children aged 3-6y from an instant full cream milk drink fortified with ferric pyrophosphate or ferric ammonium phosphate relative to ferrous sulfate as the reference fortificant.
* To compare iron absorption from ferric pyrophosphate to ferric ammonium phosphate from the milk drink


Eligibility Criteria:
Inclusion Criteria:

* 3-6 years old (inclusive)
* Normal BMI for age (WHO standard)
* Apparently healthy, no metabolic or gastrointestinal disorder
* Non-anemic (WHO cut-off for respective age
* No medication or vitamin/mineral supplements will be consumed during the study
* Intake of Vitamin/mineral supplements will be discontinued 2 weeks before the start of the study
* Parents demonstrate an understanding of the given information and ability to comply with the study procedure
* Having obtained his/her parents or his/her legal representative's informed consent

Exclusion Criteria:

* With known gastrointestinal or metabolic disorder or experiencing significant blood losses over the past 6 months
* Possible to have medication during the study
* Currently participating or having participated another clinical trial during the past 3 months prior the beginning of this study
* Subject who cannot be expected to comply with treatment
Effect of Pioglitazone on Ambulatory Blood Pressure

The anti-diabetic pioglitazone has been found to reduce casual blood pressure. To date, no data are available looking at this effect in detail. Especially, ambulatory blood pressure has not yet been utilized to confirm the hypothesis that pioglitazone has blood pressure lowering effects.


Eligibility Criteria:
Inclusion Criteria:

* Age 45-75 years
* Diabetes mellitus Type 2 (HbA1c 7 - 8.5%)
* Casual blood pressure \> = 130/80 mmHg, \< 160/100 mmHg

Exclusion Criteria:

* Therapy with insulin
* Combination therapy of sulfonyl-urea und metformin
* Therapy with nateglinid, repaglinid or an other substance of this drug family
* Allergy against pioglitazone or other composites of the tablet
* History of heart failure (NYHA I bis IV)
* Hepatic insufficiency
* Transaminases \> 2.5-fold of the upper normal limit
* End-stage renal failure
* Syndrome of polycystic ovaries
* Absence of effective contraception in women of childbearing potential
* Pregnancy or breast-feeding
Implementation of Physical Exercise at the Workplace (IRMA06) - Slaughterhouse Workers

The prevalence of pain in the shoulder, arm and hand is high among slaughterhouse workers, allegedly due to the substantial load of these body regions during work. Work disability is a common consequence of these pains. Lowering the physical exposure through ergonomic intervention may be a strategy to reduce the workload. An alternative strategy could be to increase the physical capacity through strength training of the shoulder-, arm- and hand-muscles. This study investigates the effect of two contrasting interventions, i.e. load reduction (ergonomic intervention) versus training of physical capacity (strength training) on pain and work disability in slaughterhouse workers.

The main hypothesis is that strength training intervention for 10 weeks compared with ergonomic intervention results in reduced pain of the shoulder, arm and hand.


Eligibility Criteria:
Inclusion Criteria:

* Slaughterhouse worker
* the pain should have lasted at least 3 months
* pain intensity during the last three months of \>= 3 (scale 0-10) in the shoulder, elbow or hand
* the pain should be frequent (at least 3 days per week)

Exclusion Criteria:

* life threatening disease
* pregnancy
Tap Dance for Adults With Lower Limb Amputation

The goal of this study is to determine whether it is possible for people with lower limb amputation (LLA) to perform adapted tap dance, whether an adapted tap dance program would be enjoyable, and whether it may improve balance and balance confidence.

There is a lack of research investigating therapeutic interventions for people with lower limb amputation (LLA). Tap dance encourages balance and novel movements of the limbs, while providing auditory feedback from the feet that provide information about the foot's contact with the ground, which may help prosthesis users gain a better ability to understand where their prosthetic foot is in space. As with most forms of dance, tap is usually taught and practiced in a group setting, which encourages community involvement. It has been shown to be safer than many forms of dance due to low impact forces. It also, as a genre, can incorporate canes, chairs and partner work, providing the ability to modify steps/moves when required so that they remain practical, achievable and safe for people with mobility limitations, while still enabling participation. It therefore may be an accessible dance medium to help improve balance, balance confidence, and build community for people with LLA.

Participants will be asked to:

* come to 1 hour dance classes, once per week, for 8 weeks.
* do mobility tests before and after the program
* complete questionnaires before, during and after the program. The total time for participation is approximately 8-10 weeks.


Eligibility Criteria:
Inclusion Criteria:

* unilateral or bilateral lower limb amputation at ankle level or above
* fitted with a walking prosthesis, used regularly for walking in the home and the community
* good socket fit
* able to stand or walk for 2 minutes at a time with or without an assistive device
* willing to travel to the University of Nevada Las Vegas for tap classes once a week for 8 weeks, and for two testing sessions
* able to complete all required outcome measures
* able to understand written and spoken English

Exclusion Criteria:

* leg/foot ulcer/sore or other conditions that cause pain during weight-bearing
* cardiovascular, respiratory or other critical health conditions that preclude moderate physical activity
Evaluation of Effectiveness and Safety of NOBORI Stent

The objective of this study is to evaluate effectiveness and safety of Nobori stent in the "real world" daily practice as compared with first-generation drug-eluting stents (sirolimus- or paclitaxel-eluting stents).

This study is a non-randomized, prospective, open-label registry to compare the efficacy and safety of NOBORI stents versus first-generation DES in patients with coronary artery disease.

Eligibility Criteria:
Inclusion Criteria:

* Patients receiving NOBORI stents.
* The patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethics Committee of the respective clinical site.

Exclusion Criteria:

* Patients with a mixture of other DESs.
* Terminal illness with life expectancy \<1 year.
* Patients with cardiogenic shock.