cyrilzakka/clinical-trials huggingface dataset:
Accessing the Driving Skills After the Endoscopy of Intravenous Anesthesia by Driving Simulator

The purpose of this study is to assess the driving and cognitive ability of gastrointestinal endoscopy patients at different time points after intravenous anesthesia (propofol for example), and to explore whether the driving and cognitive ability have a relationship with the blood concentration of propofol or not.

20-70 year-old volunteers who hold legitimate licenses were recruited to have gastroscopy or colonoscopy under intravenous anesthesia with propofol, and before endoscopy using driving simulator and NCT to measure patients' driving ability and cognitive function as a baseline, in the same way, assessing patients' driving ability and cognitive function after 2h, 4h of the endoscopy , meantime collecting blood samples and separating blood plasma, using HPLC (High Performance Liquid Chromatography) to measure blood concentration of propofol.

Eligibility Criteria:
Inclusion Criteria:Outpatients who held a valid driver's license,were Aged 20 to 70 years old,had more than 2 years of driving experience, were with endoscopy or colonoscopy indications.

Exclusion Criteria:with gastroscopy or colonoscopy contraindications, long-term use of benzodiazepines or opioids,an American Society of Anesthesiologists physical status score (ASA) of Class IV or V,pregnant women,Emergency and hospitalized patients, allergy to narcotic drugs, with acute and chronic liver injury, have any clinical evidence of hepatic encephalopathy,severe based diseases and mental illness,serious adverse reactions such as dizziness, nausea, and vomiting in simulated driving.
Effect of an Internet-based Dialectical Behaviour Therapy-informed Skills Training for Adult Drinkers

1. To determine the feasibility, acceptability, and preliminary effects of an internet-based DBT-ST for reducing alcohol consumption and improving psychological distress/emotional regulation in adult drinkers
2. To explore the participants' experiences and perceptions of the proposed intervention


Eligibility Criteria:
Inclusion Criteria:

* Hong Kong Chinese aged ≥18
* Score ≥8 on the Alcohol Use Disorders Identification Test
* Indicate psychological distress as measured by the Depression, Anxiety, and Stress Scale-21
* Have an intention to stop drinking
* Have an electronic device and are willing to receive interventions via the internet

Exclusion Criteria:

* Experiencing psychotic disorders/cognitive impairment/communication problems
* Participating in other alcohol abstinence/related psychosocial interventions
Breakfast Knowledge, Beliefs, and Habits of Exercising Adults

This study is being done to determine typical breakfast consumption habits in various populations of exercisers. Participants will be asked a series of questions pertaining to their participation in regular exercise, their current breakfast consumption, food preferences, meal timing, and general knowledge of sports nutrition and pre-exercise breakfast consumption.

Participants will complete a one-time survey regarding breakfast habits and beliefs and sports nutrition knowledge, as well as the type, frequency, and intensity of exercise engaged in on a weekly basis.

Eligibility Criteria:
Inclusion Criteria:

* 18+ years old
* regular exerciser

Exclusion Criteria:

* younger than 18 years old
* do not regularly exercise
Assessment of Arformoterol for Chronic Obstructive Pulmonary Disease (COPD) Using Hyperpolarized 3He MRI

The purpose of this study is to determine efficacy of MR imaging with hyperpolarized helium-3 gas in COPD patients both before and after treatment.

Hyperpolarized Helium Lung imaging has already been tested and proven to be scientifically possible in patients with a number of pulmonary disorders. However there is limited data on the sensitivity of this imaging technique, which would be essential for clinical use. This study is a double blinded study with two cohorts, each cohort being made up of patients with confirmed diagnosis of COPD. One group will receive a placebo while the other will receive treatment. A comparison of the data will resume once twenty patients have been consented and completed the study procedures.

Eligibility Criteria:
Inclusion Criteria:

* Are male or female and are 50 years or older
* Consent from the patient
* Have been diagnosed with COPD
* Must be able to hold their breath for up to 12 seconds
* Must have a baseline FEV1 ≤ 80% of predicted but FEV1 \> 0.70 L
* Must have a smoking history of 15 or more packs per year
* Must have a breathlessness severity of ≥ 2 on the Medical Research Council dyspnea scale
* Must be able to safely discontinue their respiratory medications for at least 12 hours.

Exclusion Criteria:

* Have any contraindications to an MR exam such as a pace-maker, metallic cardiac valves, magnetic material (i.e., surgical clips) implanted electronic infusion pumps or any other conditions that would preclude proximity to a strong magnetic field
* Are undergoing the MR exam in an emergency situation
* Are pregnant or become pregnant at any point within the study time.
* People with psychiatric disorders will be excluded from the study.
* Are claustrophobic and can not tolerate the imaging.
* Uses supplemental oxygen
* Have life-threatening or unstable respiratory status within 30 days before screening
* Have a diagnosis of asthma and/or any chronic respiratory disease other than COPD
* Have a lung resection greater than 1 full lobe
* Have coronary artery disease or congestive heart failure
* Are allergic to Arformoterol or similarly related drugs.
* Are taking any of the drugs listed in the risks section and are unable to stop taking them.
Radio Frequency Ablation Versus Stripping of Great Saphenous Vein in Management of Primary Varicose Veins , Comparative Study

Varicose veins are one of the most common diseases worldwide it constitutes a progressive disease which during its course it produces complications that usually prompt the patient to seek medical care.

Epidemiological studies of the incidence and prevalence of varicose veins found that the majority of adults would develop it over the course of their lifetime; women were found to be four times likely as men to develop it, the incidence of varicose vein occurrence increases with age.

Varicose veins are defined as tortuous dilated veins after or associated with incompetent valves.


Eligibility Criteria:
Inclusion Criteria:

* Inclusion criteria: -. • Adult patients with primary non complicated varicose veins which match the criteria suitable for the procedure

Exclusion Criteria:

* Patients with tortuous GSV that could not allow passage of the sheath, laser fiber, non-palpable distal pulsation.
* inability to ambulate, patients with previous history of deep venous thrombosis (DVT) and pregnant women were excluded from the study.
Immune Response in Dialysis Patients Vaccinated Against COVID-19

This is a prospective cohort study aimed to evaluate short- and mid-term immune response after SARS-CoV-2 vaccination using Gam-COVID-Vac (Sputnik V) vaccine in dialysis patients compared to the control group (medical staff).

Background and aims: Patients receiving kidney replacement therapy with dialysis are at high risk of infection and death from COVID-19. There is a lack of evidence whether SARS-CoV-2 vaccination is effective in this immunocompromised group.

Study design: this is a prospective cohort study. Two cohorts will be included: dialysis patients and controls (medical staff), both vaccinated with Gam-COVID-Vac (Sputnik V) vaccine.

Blood samples will be collected at 28 days and 22 weeks after after the second SARS-CoV-2 vaccine dose administration.

The primary outcome is the level of SARS-CoV-2 IgG antibodies on day 28 after the second vaccination as compared to controls.

The secondary outcomes are: 1) the level of SARS-CoV-2 IgG antibodies on week 22 after the second vaccination; 2) T cell subtype immunity measured by SARS-CoV-2 interferon-γ release assays (IGRA) 28 days and 22 weeks after the second vaccination.

Eligibility Criteria:
Inclusion Criteria:

* Age of 18 years or older
* Previously vaccinated against SARS-CoV-2 with two administrations of Gam-COVID-Vac (Sputnik V) vaccine
* Written informed consent.

Exclusion Criteria:

* A history of previous COVID-19 disease
* Active malignancy of any localization
* Human Immunodeficiency Virus (HIV) infection
* Maintenance treatment with immunosuppressive therapy.
A Pilot Study Testing the Efficacy of a Needling Device for the Treatment of Acne Scars

The primary objective of this study is to determine the efficacy of a needling device for treatment of acne scars.

We are investigating a needled micro-roller for use in improving the appearance of acne scars. The study is being conducted under the direction of Dr. Murad Alam of Northwestern University, Department of Dermatology.

The needles on the micro-roller are designed to create small holes in the top and mid layers of skin in order to induce the formation of more collagen, which would in turn help improve the appearance of acne scars. To qualify for the study, you must have at least 2 large areas of the face with acne scars.

The study is designed such that one part of your face, which has acne scars, will be treated with the device on 3 separate occasions, spaced 2 weeks apart at our clinic in Chicago at Northwestern. We would also ask you to return at 3 months and at 6 months to have photographs taken.

If you are interested in participating, we would like to get you involved as soon as possible

Eligibility Criteria:
Inclusion Criteria:

* Ages 18-70 years old
* Subjects in general good health
* The subject has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator
* Global Acne Scarring Classification grade 2-41 (Appendix II)
* Subject has at least two areas of acne scaring on the face (with at least 2 acne scars in each) that are at least 2 cm apart

Exclusion Criteria:

* Pregnancy and lactation
* Subjects with history of keloid or hypertrophic scars
* Subjects with active skin disease (other than mild acne) or skin infection in the treatment area
* Subjects with an active systematic or local skin disease that is likely to alter wound healing
* Subjects who have undergone in the past 6 months or planning to undergo in the next 6 months the following cosmetic treatments in the acne scar area

  * Injectable permanent filler
  * Ablative laser treatment
* Subjects taking the following prescription medications:

  * Accutane or other retinoids within the past 12 months
  * Anticoagulant (warfarin)
* Subjects who allergic to lidocaine and prilocaine
Evaluating the Effectiveness of an Early Exercise Program After Breast Reconstruction

Breast reconstruction is an important step and option after mastectomy and can help improve the quality of life of breast cancer patients. Therefore, the proportion of patients undergoing breast reconstruction in conjunction with mastectomy is steadily increasing. Despite recent advances in less invasive techniques, postoperative movement restrictions are unavoidable, and these postoperative pain or functional limitations can last for months to years. Patients most often experience a decrease in shoulder function, which negatively impacts their physical function and is an important factor in their ability to perform activities of daily living. Early postoperative exercise has been proven to have positive results in promoting the recovery of shoulder function in breast cancer patient. However, there is a lack of research on the effectiveness of early postoperative exercise in the context of breast reconstruction. Therefore, this study aims to evaluate the effect of early postoperative exercise on patients' shoulder and trunk function after breast reconstruction.


Eligibility Criteria:
Inclusion Criteria:

1. Adult women between the ages of 19 and 70
2. Pathologically diagnosed with breast cancer
3. Scheduled to undergo unilateral or bilateral mastectomy and breast reconstruction

Exclusion Criteria:

1. Adult women age 70 and order who have been diagnosed with breast cancer
2. Had surgery or radiation therapy to the same side of the armpit
3. Scheduled to undergo or have undergone delyed breast reconstruction
4. Have breast cancer that has spread to other cancers or is metastatic
5. Deemed by the healthcare provider to have unmeasurable postoperative complications (seroma, laceration, lymphedema observed within 1 month of surgery)
6. Have problems reading or understanding Korean or have problems communicating with the researcher
7. Have difficulty exercising as judged by the healthcare provider
Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy.

This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during total thyroidectomy (TTx). It compares risk-benefits and outcomes in TTx patients where NIRAF detection with PTeye for parathyroid identification is either used or not used.

Inadvertent damage or excision of a healthy parathyroid gland (PG) following a total thyroidectomy (TTx) could result in transient hypocalcemia (\< 6 months) in 5 - 35% of cases or permanent hypocalcemia (\> 6 months) in 7% of the patients (1, 2). In both of these circumstances, patients would require calcium and active vitamin D supplementation in addition to a potentially prolonged hospital stay and/or unplanned hospital readmission adding to unnecessary burden and healthcare costs. These complications could be minimized with label-free intraoperative PG identification using near infrared autofluorescence (NIRAF) detection with a fiber-probe based approach (3 - 5) as utilized in 'PTeye', which is medical device that was recently FDA-cleared (6). However, the true impact of this particular NIRAF-based approach on patient outcomes is yet to be determined

The aim of this prospective single blinded randomized study is to compare 2 groups of patients: TTx patients operated using NIRAF detection technology with PTeye as adjunct tool (NIRAF+) vs. patients operated without the adjunct technology (NIRAF-). The main objective of this study is to assess the benefit of intraoperative use of NIRAF detection technology via PTeye during TTx procedures with regard to postoperative hypocalcemia, PG identification, PG auto-transplantation and inadvertent resection rates compared to standard of care.

Eligibility Criteria:
Inclusion Criteria:

(i) All patients eligible for total thyroidectomy (TTx), with or without lymph node dissection. (includes patients undergoing a TTx who have undergone a prior neck exploration for parathyroid disease or other but have an intact thyroid).

(ii) All patients undergoing completion thyroidectomy.

Exclusion Criteria:

(i) Patients with concurrent parathyroid disease. (ii) Patients with incidental enlarged parathyroid discovered during TTx. (iii) Patients undergoing thyroid lobectomy/partial thyroidectomy.
Penile Implant Intraoperative Measurements Planning Chart

This is a chart of penile size measurements where penile length and width are recorded intra-operatively prior to penile prosthesis implantation to guide the surgeon to the correct and adequate post-operative penile size

The chart records preoperative penile dimensions as penile length and circumference both relaxed and stretched, both in a de-tumescent and erect state, before after intra-operative injection of 1cc Prostaglandin E1 respectively, to enhance pharmacological tumescence.

The implantation of the penile implant will resume with the cavernosal sparing technique.

After the penile prosthesis has been implanted, penile length and girth will be measured and the penile implant dimensions will be recorded in the chart.

The PIMP chart will assist the surgeon in assuring he sized the penis most adequately with the implant by taking the penile dimensions ( Length and Circumference). To assure that the penis was not oversized with the implant, the post-operative penile length should not exceed the pre-operative penile tumescent stretched length.

To assure that the penis was not undersized, the postoperative penile length should not be less than the pre-operative tumescent non-stretched penile length..

The chart will also document the patients' penile dimensions pre and post operatively and could be used as an objective tool for post-operative patient counseling and reassurance about the results of the penile implant surgery.

Eligibility Criteria:
Inclusion Criteria:

* Erectile dysfunction not responding to medical treatment

Exclusion Criteria:

* Patients refusing penile prosthesis implantation as a treatment modality for their erectile dysfunction
Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients

Patients with respiratory disease have an increased risk of developing complications perioperatively. The use of regional anesthesia decreases this risk with better postoperative outcome. The aim of this study is to compare the safety and efficacy of thoracic spinal versus thoracic epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease.


Eligibility Criteria:
Inclusion Criteria:

* ASA class II or III
* Mild to moderate obstructive or restrictive lung disease
* Open nephrectomy candidate patients

Exclusion Criteria:

* Any condition contra-indicating regional anesthesia
* Allergic to any of the drugs used during the procedure
Origin to Insertion Kinesio Tapping vs Non-Directional Kinesio Tapping on Quadriceps Peak Torque

This study was conducted to investigate the effect of kinesio tapping on electrical activity and peak torque of quadriceps during concentric and eccentric muscle contraction were carried out in the motion analysis Laboratory.

A Pretest posttest control group design was used to. Two hundred normal subjects of both sexes were recruited.

Subjects were randomly assigned into two groups of equal number.

* Cura Kensio-tapping group: consisted of 100 subjects (females and males) will receive kinesio taping from origin to insertion on the superficial muscles of Quadriceps femoris (vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF).
* Placebo-Group: consisted of 100 subjects (females and males) will receive placebo kinesio taping across quadriceps.

Eligibility Criteria:
Inclusion Criteria:

* Age must be ranged from 22-30 years.
* Body mass index must be ranged from 20-24.9 kg/m².

Exclusion Criteria:

* Knee or quadriceps disorders preventing physical stress.
* Cardiovascular or neurological problems.
* Athletic subjects.
* Smokers.
* Heavy caffeine intake subjects.
Intravenous Magnesium Sulphate in Acute Ischemic Stroke

Magnesium has a neuroprotective role so the investigators aim to evaluate the role of intravenous magnesium sulphate in improving the clinical outcomes as assessed by the NIH Stroke Scale (NIHSS) in patients with acute ischemic stroke.


Eligibility Criteria:
Inclusion Criteria:

* Adults with a confirmed diagnosis of ischemic stroke on neurological examination and CT scan findings aged between 45 -95 years of age of either gender.
* Adults presenting within a stroke onset of 24 hours.

Exclusion Criteria:

* Patients with confirmed diagnosis other than ischemic stroke (evidence of Intracranial bleed or space occupying lesion)

  * Subjects with systolic blood pressure less than 90mmHg
  * Presence of Bundle Branch block or atrioventricular block.
  * Serum Creatinine \> 3mg/dl
  * Respiratory failure (O2 saturation \<90% or Respiratory Rate \>24 or \<12)
  * Pregnancy.
Study Evaluating 13 Valent Pneumococcal Conjugate Vaccine With Trivalent Inactivated Influenza Vaccine

This study is to evaluate the safety, tolerability and immune response when 13-valent pneumococcal conjugate vaccine (13vPnC) and the trivalent inactivated flu vaccine (TIV) are given together to healthy adults aged 50-59 years who are naive to 23-valent pneumococcal polysaccharide vaccine (23vPS), or when the vaccines are given 1 month apart. It will also evaluate the immune response to 13vPnC once per year for 4 years and then to a second dose of 13vPnC given 5 years after the first dose.


Eligibility Criteria:
Inclusion Criteria:

* Male or female aged 50 to 59 years
* Determined by medical history, physical examination and clinical judgement to be eligible for the study
* Able to complete electronic diary
* Available for the 5 year 9 month duration of the study

Exclusion Criteria:

* Previous vaccination with any licensed or experimental pneumococcal vaccine
* Allergic to egg proteins and chicken proteins
* History of Guillian-Barre syndrome
* Vaccination with TIV within 6 months before study start
* Vaccination with diphtheria-containing vaccine within 6 months of study start
* Serious chronic disorders including immunodeficiency or metastatic malignancy
* Known or suspected hypersensitivity to any vaccine or vaccine component
EMS Providers' Health Initiative Study

This study aims to explore dietary factors that influence glycemic control in night shift EMS providers and to test the feasibility of a dietary intervention among these providers.

This study can be broken down into two phases. Both phases will take place over the course of 3 weeks. During the first week, participants will be scheduled for a single 60-90 minute zoom appointment. During this appointment, informed consent will be obtained, participants will provide health and demographic information, complete several questionnaires, and be familiarized with study protocols. The following week, participants will wear a continuous glucose monitor, actigraph activity monitor, document everything they have to eat and drink, and rate their daily stress levels. Participants will continue this during the final week and will be randomized to consume either a 2:1 or 1:1 protein to carbohydrate ratio during the night shift during this week.

Eligibility Criteria:
Inclusion Criteria:

* Emergency medical service (EMS) provider
* Works night shift only for at least one year
* Provides patient care as primary duty

Exclusion Criteria:

* Diagnosis of a metabolic disease (i.e. diabetes, prediabetes, metabolic syndrome)
* Taking medication to lower blood glucose
* Pregnant or planning to become pregnant
* Diagnosis of kidney disease or impairment
* Allergies or intolerances to study foods
* Digestive disorder