cyrilzakka/clinical-trials huggingface dataset:
Ultrasound Guided Supraclavicular and Infraclavicular Subclavian vs Catheterization in Pediatric

The aim of this study was to compare between ultrasound-guided supraclavicular and infraclavicular approaches for subclavian venous catheterization in pediatric to get clinical practice of rapid, accurate central venous catheter, insertion and less Complications.

Vascular access in children can be challenging. There is a considerable body of evidence supporting the use of ultrasound to aid central venous access in adults, but less so in children. Benefits for experienced operators may be small, but there is evidence of benefit for those acquiring skills and for less frequent operators.

Central venous catheter (CVC) placement is one of the most important invasive procedures in the intensive care for children of all ages. And health care outcomes largely depend on the success of its implementation. There are a large number of historically and clinically significant methods of central venous catheterization, and the advantages and disadvantages of each of them have been discussed for many years.

Ultrasonography is becoming an increasingly useful adjunct in the placement of Percutaneous central lines.

Eligibility Criteria:
Inclusion Criteria:

* Aged from 4 to 12 years.
* Both sexes.
* All children who need central venous line insertion.
* Intra-operative Hemodynamic monitoring.
* Volume and Inotrope Resuscitation.
* Difficult Peripheral IV Access.
* Intravenous Nutrition and Medications.

Exclusion Criteria:

* Coagulopathy.
* Distorted anatomy.
* Infection systemic or cutaneous near the proposed Point of insertion.
* Skeletal deformity.
* History of previous neck surgery.
* Head and neck mass.
* Guardian Refusal.
* Pneumothorax Or Hemothorax.
Minoxidil Response Testing in Females With Female Pattern Hair Loss

The primary purpose of this study is to evaluate the clinical validity of the minoxidil response in-vitro diagnostic kit.

Topical minoxidil is the only US FDA approved drug used for the treatment of AGA in females. While topical minoxidil exhibits a good safety profile, the efficacy in the overall population remains relatively low i.e., 30-40% re-grow hair. To observe significant improvement in hair growth, minoxidil is typically used once daily for a period of at least 24 weeks. Due to the significant time commitment and low response rate, a diagnostic test to identify non-responders prior to initiating therapy would be advantageous.

Minoxidil is converted in the scalp to its active form, minoxidil sulfate, by the sulfotransferase enzyme SULT1A1. The enzyme expression is variable among individuals. We have demonstrated in two prior feasibility studies that the SULT1A1 enzyme activity in plucked hair follicles correlates with minoxidil response in the treatment of AGA and thus can server as a predictive biomarker.

Consequently, we developed a minoxidil response in-vitro diagnostic kit intended to identify non-responders prior to initiating therapy with 5% topical minoxidil foam.

Eligibility Criteria:
Inclusion Criteria:

* Females in overall good health
* Age: 18 or older
* Female pattern hair loss
* Willing to have a mini dot tattoo placed in the target area of the scalp
* Willing to maintain the same hair style, color, shampoo and hair products use, and approximate hair length throughout the study
* Able to give informed consent
* Able to comply with the study requirements for 24 consecutive weeks
* Willing to use an adequate method of birth control (if applicable)
* Negative urine pregnancy test

Exclusion Criteria:

* Previous adverse event from topical minoxidil treatment
* History of hypotension
* Uncontrolled hypertension
* Pregnant, nursing, or planning a pregnancy during the study
* Prior hair transplant
* Uses wigs or hair weaves
* Have used minoxidil (topical or oral) anytime during the past 6 months
* Chronic scalp disorders that require medications
* Uses medication known to cause hair thinning such as Coumadin and anti-depressants/anti-psychotics
* Folliculitis
* Scalp psoriasis
* Seborrheic dermatitis
* Inflammatory scalp conditions such as lichen planopilaris
* Enrolled in any other medical study or has been enrolled in any medical study in the past 6 months
Medical vs Surgical Treatment in OSA Among Children

Adeno-tonsillar hypertrophy causing OSA are treated surgically however, over the last years it has been shown that montelukast or nasal steroidal spray can significantly improve symptoms, adenoid size, and polysomnographic results in pediatric non-severe OSA, excluding the need for surgery. A literature review from 2016 suggested that by using anti-leukotrienes as anti-inflammatory appears to be beneficial in children with a non-severe OSA and can be offered to parents as a treatment option before, or instead of surgery. In addition, nasal steroidal spray may be considered useful in decreasing adenoid pad size and the severity of symptoms related to adenoidal hypertrophy \[9\]. Despite emerging evidence that both montelukast and nasal steroids are effective in the treatment of pediatric SDB, further evidence is still required. . adeno-tonsillar hypertrophy causing OSA are treated surgically however, over the last years it has been shown that montelukast or nasal steroidal spray can significantly improve symptoms, adenoid size, and polysomnographic results in pediatric non-severe OSA, excluding the need for surgery. A literature review from 2016 suggested that by using anti-leukotrienes as anti-inflammatory appears to be beneficial in children with a non-severe OSA and can be offered to parents as a treatment option before, or instead of surgery. In addition, nasal steroidal spray may be considered useful in decreasing adenoid pad size and the severity of symptoms related to adenoidal hypertrophy. Despite emerging evidence that both montelukast and nasal steroids are effective in the treatment of pediatric SDB, further evidence is still required.


Eligibility Criteria:
Inclusion Criteria:

* children between 2-16 years of age referred to the pediatric otolaryngology outpatient clinic due to OSA and have not undergone previous adeno-tonsillar procedure

Exclusion Criteria:

* children with severe OSA who need an urgent surgery and cannot be postponed, children with nasal polyposis, craniofacial malformations (e.g. cleft lip and palate), and genetic diseases (e.g. Down syndrome).
The Roles of Cytokines in the Mechanism of Insulin Resistance and Energy Balance

Insulin resistance and disturbances in energy homeostasis are associated with body weight changes, such as diabetes, hypertension, hyperlipidemia, obesity, cancer cachexia, aging, and acute or chronic infectious diseases. Cytokines secreted by adipose tissue and inflammatory cells play important roles in the pathological conditions. Several novel cytokines were disclosed recently, but their functions have not been well known. Further investigation of these cytokines, resulting in insulin resistance and energy homeostasis, is very important to elucidate the mechanisms and develop new therapeutic strategies.

We are studying patients with body weight change, increased or decreased. Healthy people are the control group. We are recording body weight, body height, and physical exam results. In addition, we are drawing peripheral blood for further biochemical and cytokine assays.

Eligibility Criteria:
Inclusion Criteria:

* Insulin resistance condition
A Single-dose Study to Investigate the Pharmacokinetics of Intravenous FEP-TAZ in Patients With Renal Impairment

This is a Phase 1, open label, single-dose, pharmacokinetic study to be conducted in male and female subjects with normal and impaired renal function. The study will be composed of five groups of patients with mild (6 patients), moderate (6 patients), severe (6 patients) renal impairment, end stage renal disease patients on hemodialysis (6 patients) and their respective matched controls in 1:1 ratio (24 healthy subjects with normal renal function).


Eligibility Criteria:
Inclusion Criteria:

-Patients with renal impairment: mild, moderate, severe and patients on hemodialysis) that has been stable OR

* Healthy Subjects:
* Have normal renal function
* No evidence of any disease or condition that may affect pharmacokinetics of FEP-TAZ.

Exclusion Criteria:

* Evidence of hepatorenal or nephritic syndrome
* Any clinically significant abnormal findings on medical history, physical examination,or clinical laboratory tests (other than those associated with controlled diabetes,hypertension, hypercholesterolemia, dyslipidemia, or renal impairment or related or causative diseases)
A DOSE-RANGING STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-06700841 IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Assessment of PF-06700841 in participants with moderate to severe active, generalized Systemic Lupus Erythematosus (SLE) that have inadequate response to standard of care.


Eligibility Criteria:
Inclusion Criteria:

* Male and/or female subjects between ≥18 and ≤75 years of age inclusive.
* Diagnosis of moderate to severe active Lupus.
* Receiving a stable dose of methotrexate, azathioprine, leflunomide, mizoribine, mycophenolate/mycophenolic acid, anti-malarials or corticosteroids.

Exclusion Criteria:

* Active renal lupus
* Severe active central nervous system (CNS) lupus
* Have cancer or a history of cancer within 5 years of screening.
* Have a history of thrombosis (venous or arterial) or other vascular complications within the last 6 months, or any history of either recurrent thrombosis or a pulmonary embolus.
* Active bacterial, viral, fungal, mycobacterial or other infections
* Psychiatric condition including recent or active suicidal ideation or behavior
* Have active fibromyalgia/myofascial/chronic pain.
* Pregnant female subjects; breastfeeding female subjects; females subjects planning to become pregnant during the study; fertile male subjects and WOCBP who are unwilling or unable to use a highly effective method of contraception.
Assessment of Hemostatic Profile in Liver Cirrhosis

Our study included both in- and outpatients suffering from liver cirrhosis attending the out- and inpatient care of the department of hepatology. Demographic and biochemical data as well as medical history including cause of liver cirrhosis, end stage kidney failure and medication with anticoagulants were recorded. To assess the hemostatic profile, platelet function was analyzed by multiple electrode aggregometry (MEA) using Multiplate (ADP-, ASPI- and TRAP-test) and thrombelastometry using ROTEM (EXTEM, INTEM, FIBTEM).


Eligibility Criteria:
Inclusion Criteria:

* liver cirrhosis
* age of ≥ 18 years
* platelet count of at least 70 / nl

Exclusion Criteria:

* transfusion of platelet concentrate three weeks prior to inclusion
* pregnancy
* age \< 18 years
* missing informed consent
Effects of Different Exercise Training Dose on Exercise Performance and Noninvasively Estimated Muscle Oxygen Extraction in Diabetic Postmenopausal Women

The purpose of this study is specifically to investigate (1) the exercising muscle oxygenation response in diabetic postmenopausal women; (2) the dose-response of different physical activity interventions on skeletal muscle oxygenation response; (3) the related mechanisms of training effects.


Eligibility Criteria:
Inclusion Criteria:

* Sedentary postmenopausal women
* Ages 45 to 70 years old

Exclusion Criteria:

* Known cardio-respiratory disease
* Diabetic complication
* Excessive weight change during last year
* Cancer and mental disorders
Acupuncture Augmentation for Inpatients With Major Depression Disorder

Acupuncture practice is based on Traditional Chinese Medicine (TCM) principles of harmonization and balance, and the need to maintain unobstructed flow of energy (Qi) to attain efficient body functioning and metabolism so as to attain good mental and physical state of health. While increasing numbers of patients are seeking acupuncture treatment for depression in recent years, there is limited evidence of the effectiveness of acupuncture for in-hospital patients with severe depressive conditions and comorbid cognitive dysfunction, who need intensive antidepression care.

In this study, we propose a randomized clinical trial to test the clinical efficacy of acupuncture treatment for in-hospital patients who are suffering from major depressive disorder. A total of 84 patients will be 1:1 randomly assigned to 1 of 2 groups in a single-blind randomized controlled trial. The specific intervention arm involved daily augmentation TCM-style acupuncture with manual stimulation for total 10 sessions; the control arm is consisted of patients with treatment as usual (TAU), i. e. waitlist condition who will receive standard antidepressant medication with or without psychotherapies. Patients in TAU arm will be offered one free course (total 10 sessions) of acupuncture treatment in TCM outpatient clinic after they have been discharged from the ward. All patients' depressive symptoms, cognitive function, quality of life and functioning will be assessed and compared at pre-treatment (baseline), immediately after in-hospital acupuncture treatment, one-month post-treatment and 3-month post-treatment. In addition, we will analyze the association of sociodemographic and clinical characteristics with the treatment effect of acupuncture.

This study will be the first study to examine whether acupuncture is a viable augmentation treatment for in-hospital patients with depression. Expected outcomes will include determining the relative short and medium-term clinical effects from the most commonly used acupuncture treatment modalities in a local and multiethnic population.


Eligibility Criteria:
Inclusion Criteria:

1. Age ≥21 years.
2. DSM-V diagnosis of current Major Depressive Episode.
3. Montgomery-Asberg Depression Rating Scale score of 20 or more.
4. Able to give informed consent.

Exclusion Criteria:

1. History of psychosis or mania
2. With current ECT or neurostimulation treatment.
3. With severe heart or renal condition
4. Currently taking blood thinning drug including Aspirin etc.
5. Endocrine abnormalities (e.g., hypothyroidism, unstable diabetes);
6. History of central nervous system involvement (e.g., seizures, brain injury, neurologic ill- ness);
7. Pregnancy.
A Study of TAS3731 in Healthy Adults

To evaluate the safety of single and repeated administration of TAS3731.


Eligibility Criteria:
Key Inclusion Criteria:

1. Healthy adult male subjects who provided written informed consent to participate in the study
2. Aged 18 years or older and younger than 40 years at the time of informed consent
3. Body weight of 50 kg or more at screening:
4. Body mass index of 18.5 or more and less than 25.0 (Japanese) or less than 30.0 kg/m2 (Caucasian)
5. Capable of oral intake.

Key Exclusion Criteria

1. Complications or history of diseases that may affect absorption, distribution, metabolism, or excretion of the investigational drug, such as hepatic/biliary tract disease, renal/urologic disease, or gastrointestinal disease. The stomach or small intestine has been resected.
2. The 12-lead electrocardiogram at the time of the screening test was judged by the investigator to be inadequate for this study.
3. Had any concurrent disease (including symptoms and signs; however, diseases that do not affect evaluations in the study such as asymptomatic pollinosis and wart are excluded)
4. The patient has the following complications or a history of the following.

   1. Had current or previous drug abuse (including use of illicit drugs) or alcoholism
   2. Had current or previous hypersensitivity or allergy to drugs
5. Suspected COVID-19 disease.
A Simulation-based Intervention for Caregivers of Children With Seizures

Caregivers of children with seizures receiving simulation based seizure management teaching in addition to the traditional seizure teaching will report more confidence with seizure management and demonstrate a higher level of performance with seizure management.


Eligibility Criteria:
Inclusion Criteria

* Clinical diagnosis of Seizure disorder
* Dependence on a anti-seizure medication

Exclusion Criteria

* No dependence on rescue medication
Exploring Pelvic Floor Dysfunction Among Egyptian Female Athletes

This Study is aiming to identify the prevalence of pelvic floor dysfunction in female athletes in Egypt and which sports contribute more in increasing their number. helping in gathering information about the risk factors and raising awarness about Pelvic floor dysfunction

RESEARCH QUESTION:

Is there high prevalence of pelvic floor dysfunction among athletic females in Egypt and if there is specific sports contributing to that? the Sample are the Females recruited from different clubs across Egypt, female athletes who participated in previous studies and got thier contact and consent and by a Google form sent via links through social media aiming to reach a wide varieties of athletes across egypt . They will be selected according to the following eligibility criteria. the pelvic floor disability index will be used to evaluate pelvic floor. The questionnaire, transferred to Google Form, consists of 20 questions divided into three sections: Pelvic Organ prolapse Distress Inventory 6 (POPDI-6), Colorectal-Anal distress Inventory 8 (CRAD-8) and Urinary distress Inventory 6 (UDI-6). Fifteen participants, randomly selected by administrative staff, academics, and students of the Faculty of Physiotherapy at Cairo University, will test the questionnaire to identify any issues with language or format.

Data will be analyzed using IBM SPSS (version 22) for Windows. Demographic data will be analyzed using ANOVA. Bivariate correlation will be used to assess relationships between pelvic floor dysfunction and risk factors and demographic data. A p-value less than 0.05 will be considered statistically significant.

our criteria consists of

Inclusion Criteria:

* Their age will range from 16 to 60 years.
* Female gender only.
* Females engaged in regular sports or athletic activities..
* Currently residing in Egypt

Exclusion Criteria:

* Not currently involved in sports or physical activities.
* Egyptian females living outside Egypt.
* Participants involved in para-athletics. the concent from the participants is taken either verbally or Via the google form sent as mentioned above there will be a consent declaration at the beginning of the form for the participants to approve to participate.

as for the participant withdrawl : A thorough description of the procedure will be explained and they understand they may withdraw their consent and discontinue participation in this research and no consequences for the participant in withdrawing. Their data will be removed.

Eligibility Criteria:
Inclusion Criteria:

* Their age will range from 16 to 60 years.
* Female gender only.
* Females engaged in regular sports or athletic activities..
* Currently residing in Egypt

Exclusion Criteria:

* Not currently involved in sports or physical activities.
* Egyptian females living outside Egypt.
* Participants involved in para-athletics.
Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.

Patients with adrenal insufficiency are most often overdosed with hydrocortisone. To date, there is no reliable marker that can reflect the quality of hydrocortisone substitution. Salivary cortisol is a good reflection of free plasmatic cortisol. However, salivary contamination with the oral intake of hydrocortisone has been described.

The aims of the study are to:

* evaluate the frequency of salivary contamination by hydrocortisone taken in tablet form and determine its risk factors.
* evaluate the quality of hydrocortisone substitution in patients with corticotrope deficiency.

Patients with adrenal insufficiency are most often overdosed with hydrocortisone, as evidenced by the higher frequency of metabolic disorders, osteoporosis and cardiovascular mortality in these subjects compared to healthy subjects. To date, there is no reliable marker that can reflect the quality of hydrocortisone substitution. Salivary cortisol is a good reflection of free plasmatic cortisol. However, salivary contamination with the oral intake of hydrocortisone has been described.

The aims of the study are to:

* evaluate the frequency of salivary contamination by hydrocortisone taken in tablet form and determine its risk factors.
* evaluate the quality of hydrocortisone substitution in patients with corticotrope deficiency.

It is a cross over clinical trial with three arms: patients taking tablets of hydrocortisone, patients taking capsules of hydrocortisone, and healthy control subjects undergoing one day test. Salivary cortisol is measured before, at one, two and four hours after hydrocortisone intake.

Eligibility Criteria:
Inclusion Criteria:

-patients with corticotrope deficiency treated with hydrocortisone for at least one year.

Exclusion Criteria:

* alcoholism,
* morbid obesity,
* long standing or uncontrolled diabetes mellitus,
* uncontrolled hypothyroidism,
* depression,
* chronic or acute inflammatory or infectious disease,
* neoplasia,
* renal or hepatic disease,
* malabsorption,
* pregnant or breast-feeding women,
* treatment with corticosteroids other than hydrocortisone, enzyme inducers or oestrogens.
Infection Prevention and Control Practices Regarding COVID-19

Background: Healthcare providers, particularly nurses, are at risk of infection as part of the COVID-19 epidemic chain since they assist in the disease's containment. By recognising the risk factors for infection and implementing suitable measures to reduce these risks, all reasonable efforts should be taken to control the spread of infection to them. The major aim of the present study was to determine the level of infection prevention and control practises used by primary healthcare nurses in Saudi Arabia during the COVID-19 pandemic.


Eligibility Criteria:
Inclusion Criteria:

* Male and female healthcare practitioners with at least one year of experience and who worked in all areas of primary healthcare facilities during the COVID-19 epidemic.

Exclusion Criteria:

* Healthcare providers that are unwilling to participate in the present study have been eliminated