cyrilzakka/clinical-trials huggingface dataset:
Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT II)

The purpose of this study is to test whether physicians can make more informed treatment, admission, and discharge decisions related to patient care by having serial Triage® BNP test results available to assess disease severity, while patients are being treated for HF in the Emergency Department and/or during their admission. This is believed to lead to a better outcome as well as more efficient and cost-effective treatment.

This is a patient-randomized clinical study consisting of patients who present to the ED requiring treatment and/or admission for HF. At each site, patients will be randomized into either a control arm or an experimental arm. Serial blood samples will be collected from all patients throughout their stay in the ED and the hospital. In the experimental arm, the Triage® BNP test will be performed on all blood samples collected and each BNP result will be made available to the attending physicians immediately. In the control arm, blood samples will not be analyzed on-site for BNP but instead sent directly to Biosite Inc. for testing.A comparison will be made between the control and experimental arms of the study to determine if there are any significant differences in length of stay, re-hospitalizations, all cause mortality, BNP levels, quality of life, and costs to treat patients.

Eligibility Criteria:
Inclusion Criteria:

Age 18 and older Patient needs treatment for HF

Exclusion Criteria:

Current MI or ACS with ST deviation of 1 mm or greater Renal failure requiring dialysis Undergone hemodialysis within the last month Enrollment (Baseline) Triage® BNP concentration = 100 pg/ml or less Enrolled in any other drug trial or receiving an experimental treatment for HF.
Neuronal Damage In Delirium Study

The purpose of this study is to evaluate associations between neuronal damage biomarkers (S100 calcium-binding protein beta \[S-100β\], neuron-specific enolase \[NSE\], ubiquitin carboxy-terminal hydrolase L1 \[UCHL1\], and brain-derived neurotropic factor \[BDNF\]) and delirium severity and subsyndromal delirium in a homogeneous population of mechanically ventilated patients with sepsis.

Due to high levels of inflammation, patients with sepsis are especially at risk of developing delirium, an organic state of confusion that affects over 80% of mechanically ventilated patients during their intensive care stay. A growing body of literature suggests that the severity of delirium symptoms may also have a significant impact on negative outcomes associated with delirium, including mortality, length of hospital stay, duration of mechanical ventilation, and functional and cognitive impairment. Similarly, recent literature suggests that patient outcomes may be worsened by a subthreshold severity level of delirium, known as subsyndromal delirium. Despite the urgent need to understand delirium and subsyndromal delirium etiology for better detection and management strategies, the multifactorial pathophysiology of delirium is still largely unknown. Clinical biomarker studies evaluating levels of S100 calcium-binding protein beta (S-100β), neuron-specific enolase (NSE), ubiquitin carboxy-terminal hydrolase L1 (UCHL1), and brain-derived neurotropic factor (BDNF) have suggested evidence for their role in delirium pathophysiology, but significant associations with delirium severity and subsyndromal delirium have not been reliably established. Evaluating the dose-response relationship of S-100β, NSE, UCHL1, and BDNF with delirium severity and subsyndromal delirium in a homogeneous population of mechanically ventilated patients with sepsis will provide novel insight on the etiological pathway of delirium. The investigators will evaluate effect modification and confounding by inflammation and blood-brain barrier permeability by measuring well-established biomarkers, interleukin-6 (IL-6) and E-selectin, respectively. Understanding the role of neuronal damage in delirium may be a promising avenue to develop better screening practices and neuroprotective management strategies that may reduce long-term cognitive and functional deficits associated with delirium.

Eligibility Criteria:
Inclusion Criteria:

* Located in FMC ICU
* Able to consent or have a surrogate decision-maker able to consent
* Richmond Agitation and Sedation Scale Score ≥ -3
* Glasgow Coma Scale (GCS) score ≥ 9
* Able to communicate with the study team (English language, no hearing impairments)
* Expected to remain in the ICU longer than 24 hours
* Sequential Organ Failure Assessment (SOFA) score ≥2 (indicates sepsis based off of Sepsis 3 Guidelines)
* Invasively mechanically ventilated

Exclusion Criteria:

Neurological injury or neurodegenerative condition
Effect of Physical Activity Through Interactive Video Games in Overweight Children

The purpose of this study is to determine the effect of interactive video game in management of overweight in children. The investigators will evaluate the effect of product versus standard physical activity.

Background. Child Overweight and obesity are a world public health problem, in low income countries is more. One difficulty in the management is the poor adherence to physical activity, some studies show that active video games could improve this.

Objective: Establish the effect of the introduction of active video game (Nintendo Wii) on fitness, anthropometry and adherence to treatment, as part of an intervention program for the management of childhood obesity in children over 5 years of age with obesity Methodology: A clinical trial, randomized and controlled. children between 5-10 years with a diagnosis of overweight or obese, were divided into two groups. (Wii group), received 3 weekly sessions of one hour of physical activity by an active video game, the other group (control group) received 3 weekly sessions of one hour of physical activity by static exercises.

Eligibility Criteria:
Inclusion Criteria:

* children aged 5-10 years with a diagnosis of overweight or obese (according to WHO criteria)

Exclusion Criteria:

* overweight or obese due other disease.
Sensation of Dyspnea and Experience of Patients With Heart Failure

This randomized clinical trial aims to evaluate patients with decompensated heart failure undergoing an early mobilization protocol with the use of immersive virtual reality glasses compared with patients undergoing the same protocol but without immersive virtual reality. The primary outcome will be the sensation of difficulty breathing, and the secondary outcome will be whether this technology provided a positive experience for patients in the intervention group that was superior to that of patients in the control group.

This randomized clinical trial aims to assess the sensation of dyspnea in patients undergoing an early mobilization protocol with immersive virtual reality and their experience using this technology. The study population consists of patients with acute decompensated heart failure in an intensive care unit at a teaching hospital. The 3-day protocol will include active exercises with an in-bed cycle ergometer, orthostasis, and ambulation. The intervention group will perform all exercises using virtual reality glasses. The variables will be collected before and after each intervention.

Eligibility Criteria:
Inclusion Criteria - Patients with 18 years or older

* Being hospitalized for 24 hours or more
* Diagnosis of acute heart failure decompensated
* Being lucid and colaborative

Exclusion Criteria:

* Mechanical ventilation or circulatory support
* Neurodegenerative diseases
* Pregnant patients
* Hemodynamic instability at baseline
* Score on the Borg Rating of Perceived Exertion Scale Borg ≥ 4 at rest
* High risk of falls
* Difficulty communicating
* Not adapt with the immersive virtual reality glasses
Anesthesia for Ambulatory Pediatric Surgery in Sub-Saharan Africa (SSA)

Long surgical wait-times and limited hospital capacity are common obstacles to surgical care in many countries in sub-Saharan Africa (SSA). Ambulatory surgery might offer a solution to these problems. The aim is to study the introduction of ambulatory surgery in a pediatric hospital in SSA.

This is a cross-sectional descriptive study which took place over 6 months. It includes all the patients assigned to ambulatory surgery in the Pediatric University Hospital in Ouagadougou, Burkina Faso.


Eligibility Criteria:
Inclusion Criteria:

* ASA 1 status
* elective surgery with low potential for blood loss or severe pain, lasting less than 90 minutes
* whose parents could be contacted by telephone and who could return to the hospital in less than 1 hour
* Parents gave consent for the surgical procedure

Exclusion Criteria:

* non operative patients
Beta Blocker Effects in Traumatic Brain Injury

The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma to evaluate effects of beta blocker on patients with TBI.

The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma . Patients will be randomly assigned into two groups by sealed envelope technique into two equal groups.

Parameters assessment:

* Length of ICU stay
* Length of total hospital stay
* CT scan to exclude another intracranial hemorrhage or increase in hemorrhage
* Functional status will be assessed using the GCS
* Hemodynamic data ( bl.p / hr )
* Crystalloid volume that patient need in 24h
* Mortality rate

Eligibility Criteria:
Inclusion Criteria:

* GCS preoperative \>10
* Abbreviated Injury Scale (AIS) \>3
* Length stay in ICU \>48 h

Exclusion Criteria:

* Hypersensitivity to propranolol
* Asthmatic patient
* COPD
* History of smoking
* Any cardiac problems eg: ( heart failure or HB )
* pheochromocytoma
* Pregnant patient
* Length stay \<48h
* Death within 48 h of admission
* Patient who previously received any beta blocker at home.
* Symptomatic Bradycardia \<60 b/m (sick sinus syndrome)
* Hemodynamic unstable patients
Long-Term Clinical Follow-Up of Children Enrolled in Stannsoporfin Clinical Trial Protocol No. 64,185-06-2(W)

The purpose of this protocol is to provide a mechanism to collect Long Term Clinical Data from those babies who participated in the primary Study 64,185-06-2(W)(WS)(ISNHP) "An Open-Label Study Of The Safety And Clinical Pharmacology Of Stanate® In Infants At-Risk For Exchange Transfusion".

The purpose of this protocol is to provide a mechanism to collect Clinical Data from those babies who participated in the primary Study 64,185-06-2(W)(WS)(ISNHP) "An Open-Label Study Of The Safety And Clinical Pharmacology Of Stanate® In Infants At-Risk For Exchange Transfusion". Data on long-term impact of Stannsoporfin on the physical, neurological, neurodevelopmental, biochemical, metabolic and hematopoietic profiles of the children will be collected at 9 and 18 months, 3, 6 and 9 years after Stannsoporfin administration

Eligibility Criteria:
Inclusion Criteria:

* All children who have been enrolled and received Stanate® Injection/Placebo in Study Protocol 64,185-06-2(W)(WS)(ISNHP) are eligible for this follow-up.

Exclusion Criteria:

-
Patterns of Congenital Heart Diseases at Sohag University Hospital

Congenital heart diseases (CHD) are structural or functional heart diseases that present at birth even if it is discovered later in life .

Congenital heart disease is caused by disturbance in the normal development of the heart especially during the first 6 weeks of pregnancy. Researchers aren't sure about the exact cause , but they think genetics , certain medical conditions , some medications and environmental factors, such as smoking, may play a role .

CHD in many cases may be asymptomatic and discovered accidently during the routine examination or may be presented by some clinical manifestations (e.g. Cyanosis or Murmers) and /or complications (e.g. Heart Failure Manifestations : Tachycardia , Tachypnea , Dyspnea during feeding , Diaphoresis especially during feeding

,Restlessness, irritability , Hepatomegaly , and Failure To Thrive) .

Recently diagnosis of congenital heart disease is better by using advanced technology e.g. echocardiography, magnetic resonance imaging (MRI), cardiac catheterization, angiography, and radio-active isotopes . and early diagnosis is very important as regard the manangement of the disease .

As medical care and surgical interventions have advanced over time, the treatment of many abnormalities is now available . and many infants and children with congenital heart defects are living longer and healthier lives. Many are living into adulthood, requiring ongoing, lifelong medical care for their conditions .

So information about different aspects of CHD is very important for planning health programs for long-term care and maintenance for these cases .


Eligibility Criteria:
Inclusion Criteria:

* All children from date of birth to age of 12 years old including both genders diagnosed to have CHD .

Exclusion Criteria:

* More than 12 years old .
* Acquired heart diseases
* Children with heart rate abnormalities
Effects of Intra Muscular Electrotherapy Combined With Manipulative Therapy in Patients With Sacral Torsion

This study is a randomised controlled trial and the purpose of this study is to determine the effect of intra muscular electrotherapy combined with manipulative therapy in terms of pain, mobility, range of motion, and disability."

The purpose of this study is to determine the effect of intra muscular electrotherapy combined with manipulative therapy in terms of pain, mobility, range of motion, and disability in patients with sacral torsion." (age : 22-44 years )

1. Numeric pain rating scale
2. Inclinometer Lumbar Flexion
3. Oswestry Disability Questionairre
4. Goniometer SLR ROM Data will be collected before and after the intervention protocol for each participant.

Data collection procedure: Participants of interest would be approached and explained about the research. Informed written consent will be taken. Pre and post intervention scores will be recorded.

Eligibility Criteria:
Inclusion criteria:

* Age group: 22-44 years old
* Both males and females
* Clinically diagnosed sacral torsion
* Patients with pain intensity of at least 5 on NPRS
* Positive backward bent test
* Positive forward bent test
* Uneven Sacral sulcus
* Uneven ILA of sacrum
* Piriformis syndrome

Exclusion criteria :

* Any congenital deformities
* Demonstrated neurological deficit.
* Pregnant females
* History of spinal surgery
* Spondylolisthesis
* Severe lumbar spondylosis
* Spinal stenosis
* Serious spinal conditions like infection, tumors, osteoporosis, spinal fracture
* osteoporosis
AMIE's Clinical Conversational Abilities in an Urgent Care Setting

The purpose of this study is to determine the feasibility of a conversational artificial intelligence (AI) system to have a meaningful clinical conversation with a patient prior to an urgent care visit with their primary care physician. In this study, patients who are seeking an urgent care visit (that is, any type of medical visit with their primary care provider for a new complaint) will first have a conversation with an AI system. This interaction with the AI system will happen less than a week before their visit with their physician, and will be supervised by an independent physician who will interrupt in case there are any concerns about patient safety. After the interaction, a summary of the conversation will be sent to the patient's PCP, who will review prior to the in-person visit.

The researchers will investigate:

* Patient views on the AI system
* PCP views on the AI system
* Overall safety, as measured by the physician safety supervisor
* Quality of clinical conversations, measured by standardized rubrics
* Quality of diagnostic and management plans generated by the AI; these will not be shared with the patient or physician, but will be generated after the fact and compared with the actual diagnosis and management plan.

This study is a pilot study on the ability of the Articulate Medical Intelligence Explorer's ability to have a clinical conversation with urgent care patients. After recruitment into the study, but prior to seeing their primary care physician (PCP), patients will log in to the AMIE chat interface via a secure web application and share their screen via a secure, HIPAA-compliant video conferencing program. They will then interact with AMIE, having a clinical conversation. A physician safety supervisor will be on the call the entire time and will view the chat as it happens. This doctor will interrupt the chat if there are any potentially harmful interactions. At the end of the call, the safety supervisor will discuss with the patient and correct any errors, hallucinations, or problems with the AI. The patient's PCP will receive both a summary and a transcript of the chat prior to their appointment. The patient will then proceed to their urgent care appointment as previously scheduled. Four weeks after the visit, the researchers will perform a chart review to extract a "ground truth" diagnosis from the urgent care visit, if possible. As this is a pilot study, the primary endpoint will be recruitment; the target is between 100 to 200 patients and the study will continue until saturation of different diagnoses has been reached.

Eligibility Criteria:
Inclusion Criteria:

* Age \> 18
* English included as a primary language in the electronic health record
* Patient is seeking episodic (urgent) care at HCA

Exclusion Criteria:

* Age \< 18
* English not listed as a primary language in the electronic health record
* Visit reason is related to pregnancy
* Visit reason is a psychiatric concern
* Visit is to establish care, or for follow-up care
Ologen(Oculusgen)-Glaucoma and Pterygium Historical Control Study in China Shanghai Sixth People's Hospital

The purpose of this study is to determine whether the ologen (OculusGen) Collagen Matrix are effective and safe to implant as an aid of glaucoma surgery and pterygium excision surgery.

ologen (OculusGen) Collagen Matrix is a porous, scaffold matrix. It is to be implanted on the top of the scleral flap and beneath the conjunctiva and Tenon's capsule at the end of trabeculectomy. The pores in the scaffold matrix range from 20 to 200µm, a size that is suitable for fibroblasts to grow randomly, through the body of the matrix without causing scarring. The space occupied by the collagen matrix scaffold creates room for the development of a filtration bleb. Immediately after implantation, the collagen matrix is absorbed with the aqueous humor that bring a certain pressure press on the top of scleral flap which makes the dynamic balance for the aqueous system to keep the IOP in the right side. The collagen matrix is bio-degraded within 90 days and will leave a physiologic space for the filtration bleb to facilitate control of intraocular pressure (IOP).

Eligibility Criteria:
Inclusion Criteria:

* Age 18 years or over
* Patient able to cooperate with study procedures and able to perform tests reliably
* Patient willing to sign informed consent
* Patient able and willing to complete postoperative follow-up requirements
* Glaucoma：one/both eyes are affected by glaucoma
* Pterygium： patient with pterygium

Exclusion Criteria:

* Known allergic reactions to collagen
Diagnosis of Peripheral Lung Nodules Using Cryobiopsy

Since the traditional radial endobronchial ultrasound guided biopsy technique of solitary pulmonary nodules using the forceps has several shortcomings, the purpose of this study is to investigate a new biopsy technique using the transbronchial cryobrobe

This is a prospective randomized trial to assess diagnostic accuracy and safety of cryobiopsy using two different outer diameters. Included patients are 1:1 randomized to receive forceps biopsy following cryobiopsy with a 1.1mm or 1.7mm cryoprobe.

Eligibility Criteria:
Inclusion Criteria:

* Solitary pulmonary nodule with indication of bronchoscopic diagnostic approach
* Age between 18 and 90 years
* Written informed consent after participant's information

Exclusion Criteria:

* Age \< 18 and \> 90 years
* Lacking ability to form an informed consent (including impaired judgement, communi-cation barriers)
* Contraindication against bronchoscopy (e.g. co-morbidities)
* INR \> 2 or Thrombocytes \< 50000
* Double antiplatelet drugs (e.g. ASS and Clopidogrel) within 7 days before biopsy
* Anticoagulation with NOAK within 48 hours before biopsy
* Moderate or severe pulmonary hypertension (mPAP \> 30 mmHg, RV/RA \>30 mmHg)
* Tumors suspicious of endobronchial growth
The Effect of Tele-Nursing Application on Self-Care Ability and Daily Living Activities in Fracture Surgery Patients

This study aims to determine the effect of tele-nursing application based on Orem's Self-care Theory on self-care agency and daily living activities in trauma-related lower extremity fracture surgery patients.

The research was conducted to determine the effect of tele-nursing application based on Orem's Self-care Theory on self-care agency and daily living activities in trauma-related lower extremity fracture surgery patients. The research was planned as a randomized controlled experimental type study. 52 patients (intervention 26, control 26) were included in the study sample using the "simple randomization method". In order to collect the data, Introductory Information Form, Self-Care Agency Scale, KATZ Activities of Daily Living Scale and Lawton Brody Activities of Daily Living Scale were used. Current hospital procedures were applied to patients in the control group without any intervention. Patients in the intervention group were monitored with a tele-nursing application based on Orem's Self-Care Theory, and training and counseling were provided for 6 weeks after discharge. Data; It was collected face to face once before discharge in both groups, and three times by video conference method: 7-10 days, 18-21 days and 40-45 days after discharge. Tele-Nursing Application Monitoring Form and reminder infographics, prepared based on Orem's Self-Care Theory, were used in the follow-up process of patients who had trauma-related lower extremity fracture surgery. Chi square, independent samples t test, analysis of variance in repeated measurements and Pearson correlation analysis were used to analyze the data. While there was no statistical difference between the groups in the first measurements, in the 2nd, 3rd and 4th measurements, the intervention group's self-care agency, KATZ activities of daily living and Lawton Brody instrumental activities of daily living scale scores were found to be statistically significantly higher than the control group (p\<0, 05). In this study, it was concluded that tele-nursing application based on Orem Self-Care Theory has a positive effect on self-care agency and daily life activities.

Eligibility Criteria:
Inclusion Criteria:

* Between the ages of 18-65,
* Agreeing to participate in the study voluntarily,
* Able to understand and speak Turkish,
* At least primary school graduate,
* Those who have undergone lower extremity fracture surgery,

Exclusion Criteria:

* Over 65 years of age,
* Having an uncontrollable medical problem,
* Having a hip fracture or fragility fracture due to a fall,
* Having an external fixator,
* Amputation develops,
* People whose speech, hearing and visual disabilities prevent them from participating in telenursing monitoring will not be included in the study.