cyrilzakka/clinical-trials huggingface dataset:
Evaluation of the Online Memory & Aging Program and Online Goal Management Training

The current study is designed to test the effectiveness of online programs for memory and executive functions in healthy aging. The investigators are testing online adaptations of two cognitive interventions that have been extensively studied, validated, and implemented in clinical settings: The Memory \& Aging Program (MAP) targets normal memory change in healthy aging, and Goal Management Training (GMT) targets executive functioning deficits in a variety of cognitive and neurological conditions including healthy aging. Both programs combine psycho-education, targeted skills training and clinical support to empower participants with knowledge and strategies to harness their cognitive faculties. These programs are being tested against a waitlist control as well as against a commercial/research brain training platform (Cambridge Brain Sciences) in a design comparing performance on memory and executive functioning measures before and after the interventions/controls. The main hypothesis is that MAP will lead to memory-specific improvements above control conditions, whereas GMT will lead to greater improvements in measures of executive functions relative to controls.


Eligibility Criteria:
Inclusion Criteria:

* Available to participate in all testing and intervention sessions and access to a computer
* Computer familiarity
* Cognitive complaint/concern/frustration

Exclusion Criteria:

* Health conditions with major effects on cognition, including a current or previous history of stroke, brain surgery, or diagnosed neurological disorder;
* Dependence in instrumental activities of daily living
* Cognitive impairment, defined as performance below cutoff for cognitive impairment on a standardized cognitive screening measure, the modified Telephone Interview for Cognitive Status (Welsh et al., 1993)
* Affective impairment, defined as performance below cutoff for depression on standardized depression screen, the PHQ 2/9 (Yesavage et al., 1983)
Hemodynamic Parameters in Euthyroid Patients With Thyroid Nodules

The purpose of this study is to determine the relationship of hemodynamic parameters with the level of thyroid hormones and the histological structure of thyroid nodules in euthyroid patients.

As opposed to widely investigated condition of cardiovascular system in patients with functional disorders of thyroid gland, the relationship between thyroid hormones and hemodynamic parameters in euthyroid patients remains not enough clear.

We detect the parameters of blood pressure and thyroid hormones in euthyroid patients with thyroid nodules directly before planned operation on the thyroid gland.

As the study is carries out directly before operation, that assumes presence of preoperative stress in patients, activity of the sympatho - adrenal system is estimated in addition.

On the one hand, the design of our research will allow to estimate relationship of thyroid hormones with the parameters of blood pressure in conditions of euthyroidism, on the other hand - to investigate features of blood pressure in patients with thyroid nodules.

The research of the patients in the preoperative period will enable to select the group of patients without pathology of cardiovascular system whose increased blood pressure is connected with preoperative stress, that in turn will allow to exclude influence of the pathology of the cardiovascular system on studied correlation.

Eligibility Criteria:
Inclusion Criteria:

* Euthyroid patients with thyroid nodules before operation on the thyroid gland

Exclusion Criteria:

* Hyperthyroidism
* Hypothyroidism
The Effect of Motivational Interviewing-Based Breastfeeding Education on Breastfeeding Motivation and Self-Efficacy

This study is being conducted to examine the effect of a motivational interviewing-based breastfeeding education intervention provided to mothers whose infants are hospitalized in the neonatal intensive care unit on the mothers' breastfeeding motivation and breastfeeding self-efficacy.

Midwives and nurses working in the Neonatal Intensive Care Unit (NICU) are in a unique position to support the breastfeeding process and breastfeeding self-efficacy of mothers whose babies are hospitalized in the NICU. Health care professionals can use a variety of methods to support mothers' breastfeeding self-efficacy and encourage breastfeeding. Individualized interventions, breastfeeding education, and motivational interviewing are some of them. Motivational interviewing is basically a client-centered psychosocial intervention that helps individuals discover and resolve ambivalent feelings about health behaviors, learn new skills, and improve existing skills. In the breastfeeding process, the mother's motivation and positive intention are shown to be important indicators of breastfeeding continuation.

Health education about breastfeeding provided by neonatal intensive care nurses to mothers whose babies are hospitalized in the NICU for various reasons is one of the important initiatives of nurses. The contribution of health education planned with effective educational techniques for both mother and baby is undoubtedly very valuable. However, one of the important variables that should not be forgotten in the success of this education provided by the nurse is motivation, which also affects the self-efficacy of mothers regarding breastfeeding. In order to ensure the readiness of mothers to be educated about the breastfeeding process and breastfeeding of the infant hospitalized in the NICU, it would be appropriate to support the health education planned for mothers whose infants are hospitalized in the NICU with a motivational interviewing intervention. Based on this information, the planned research will examine the effect of motivational interviewing-based breastfeeding education provided to mothers whose infants are hospitalized in the NICU on mothers' breastfeeding motivation and breastfeeding self-efficacy.

Eligibility Criteria:
Inclusion Criteria:

* A baby born at 38-42 weeks gestational week admitted to the NICU,
* Who started breastfeeding her baby in the NICU,
* Literate in Turkish,
* Open to communication and cooperation,
* Volunteered to participate in the study,
* Willing to breastfeed your baby,
* Have a smart phone and internet connection,
* Mothers who scored 60 or less on the Breastfeeding Self-Efficacy Scale in the pretest

Exclusion Criteria:

* Any chronic illness and pregnancy complications,
* A condition that prevents breastfeeding,
* The mother has a diagnosed psychiatric illness,
* Mothers with a history of substance abuse.
* The presence of an obstacle to oral feeding and sucking in the infant,
* The baby has genetic, congenital anomalies, neurological, cardiac and metabolic diseases,
* The baby has undergone surgery.
Comparison of Antimicrobial Coated Ureteral Stents With Non-coated Stents

This study will be conducted to compare the efficacy of antimicrobial coated ureteral stent with non-coated stents in prevention of UTI in patients with ureteral stents

The efficacy of antimicrobial coated of ureteral stent with silver sulphadiazine in prevention of UTI in patients with ureteral stents will be studied by comparining the results of urine and stent cultures with patients who had non-coated ureteral stents. The impact of antimicrobeal stent coating on patients' quality of life will be evaluated with comparing the scores of ureteral stent symptom questionnaire between both groups.

Eligibility Criteria:
Inclusion Criteria:

* Patients who will undergo ureteral stent placement

Exclusion Criteria:

* Patients allergic to sulpha containing medications
* Ureteral stent insertion for infected hydronephrosis
* Patients who developed septic complications requiring antibiotic treatment after stent placement
* Patients who need bilateral stents
* Patients with chronic kidney disease grade IV and V (GFR \<30ml/min)
* Immunocompromised patients as those with malignancy or organ transplantation.
Ultrasound-guided Peripheral Vascular Access: What Approaches in Paediatrics?

Landmarks used to make a vascular puncture has long been based on the only knowledge of anatomy. This method assumes that the target vessel is in its expected position, permeable (non-thrombosed), and heavy enough to be catheterized. Any variations from these assumptions is likely to cause failures of puncture and complications. The development of ultrasound allowed to "see" the structures to achieve, whether before a puncture or in live for guiding the procedure. Visualization of vessels and adjacent structures has logically resulted in larger cases to a greater security of catheterization, improving the success rate, and decreasing complications. Several positions of the probe can be used to guide a puncture under ultrasound: the transversal approach in short axis, the long axis longitudinal approach and the oblique view approach.The aim of the study was to compare these three different ultrasound-guided approaches to peripheral vascular access in children. All children weighing less than 30 kg that should benefit from the introduction of an arterial catheter or central venous catheter introduced through a peripheral vein are eligible. Patients will be included after parent's and children's information and consent. The choice of the technique used (transverse, longitudinal or oblique approach) is determined by a randomization table.The puncture procedure is performed according to the usual protocols of the paediatric anesthesia unit of the investigators, under ultrasound guidance in a sterile manner. No time limit is required for the identification and implementation of the catheter. The position of the probe is dictated by the result of randomization and the Seldinger technique is used for the establishment of the catheter. Beyond two unsuccessful attempts, the procedure is considered as a failure. The anesthetist then uses the alternative technique of his choice. All anesthetists participating in this study exercised their main activity in the Montpellier University Hospital pediatric anesthesia unit. The laying of ultrasound-guided peripherally inserted central catheter and arterial catheter is part of the current activity of the unit.


Eligibility Criteria:
Inclusion Criteria:

1. Child requiring the implementation of a peripherally inserted central catheter or an arterial catheter.
2. Child whose general state corresponds to the Physical status score I - IV
3. Child whose weight is lower to 30 kg
4. Child whose parents will have given their informed consent.
5. Child affiliated to a national insurance scheme

Exclusion Criteria:

1. Child presenting a contraindication to the general anesthesia
2. Child whose weight is upper to 30 kg
3. Child whose parents did not give their informed consent
Copeptin During a Standardized Psychological Stress Test

The aim of the PsyCo Study is to determine whether psychological Stress has an influence on copeptin levels.

healthy volunteers undergo the TSST and stress hormones as cortisol and copeptin are measured

Eligibility Criteria:
Inclusion Criteria:

•Aged over 18 years

Exclusion Criteria:

* Intake of any kind of medication (except birth control pill)
* BMI \>30 kg/m2
* Evidence of any acute illness
* History of chronic illness
* Baseline glucose level \>7 mmol/l Baseline sodium level \<135 mmol/l or \>145 mmol/l
Correlation Between Cervical Spine Sagittal Alignment and Functional Disability in Preparatory School Students With Mechanical Cervical Pain

Neck pain is a major public health concern that has been extensively studied in adults but not in children and adolescents. Mechanical neck pain became prevalent among children and adolescents, and has its impacts on functional ability.

This study is aiming to investigate the correlation between Cervical spine sagittal alignment parameter (cranio-cervical angle) and functional disability in preparatory school students with mechanical cervical pain.

* Correlational study between cranio-cervical angles and functional disability in students with mechanical cervical pain.
* Inclusion Criteria Age between 12 and 15 years, either sex, and cervical symptoms lasting longer than three months.
* exclusion criteria Spinal pathologies or surgery, or any other deformities or visual or auditory issues, as well as ongoing physical or medical treatment for cervical pain

Eligibility Criteria:
Inclusion Criteria:

* Age between 12 and 15 years, either sex, and cervical symptoms lasting longer than three months.

Exclusion Criteria:

* Spinal pathologies or surgery, or any other deformities or visual or auditory issues, as well as ongoing physical or medical treatment for cervical pain
The Kampala Trauma Score in the Outcome of Polytrauma Patients

The goal of this observational study is to learn about the predictive value of the Kampala Trauma Score in Egypt.

The main question it aims to answer is:

How does the performance of the Kampala Trauma Score compare to the Estimated Injury Severity Score in predicting outcomes for multi-traumatic patients in Egypt? Participants are adult polytrauma patients admitted to the emergency department during the study period.

Two prominent scoring systems used in trauma care are the Kampala Trauma Score (KTS) and the Estimated Injury Severity Score (EISS). The KTS was specifically designed for use in low-resource settings, offering a practical tool for predicting patient outcomes based on readily available clinical data. This score integrates parameters such as age, systolic blood pressure, and Glasgow Coma Scale (GCS) scores, making it suitable for environments where advanced diagnostic tools may be lacking. Previous research has demonstrated the KTS's utility in various resource-limited settings, highlighting its role in effectively stratifying trauma patients and guiding triage decisions.

In contrast, the Estimated Injury Severity Score (EISS) is an adaptation of the Injury Severity Score (ISS), which incorporates both clinical and radiographic data to assess trauma severity comprehensively. The EISS uses an estimated approach to account for the often incomplete or preliminary information available in some clinical settings, aiming to provide a robust prediction of patient outcomes. While it is a more comprehensive tool than the KTS, its reliance on advanced imaging and detailed clinical information may limit its applicability in settings with restricted resources.

This study aims to conduct a cross-sectional comparison of the KTS and EISS to evaluate their relative effectiveness in assessing trauma severity and predicting patient outcomes. The results will provide valuable insights into the optimal use of trauma scoring systems and potentially inform improvements in trauma care practices

Eligibility Criteria:
Inclusion Criteria:

* Adult polytrauma patients
* Both genders

Exclusion Criteria:

* Patients with incomplete data or those who decline participation.
* Patients with multiple comorbidities.
* Patients managed outside the hospital.
Feasibility of Assessing Lymphoma Response to Precise Local Injection of Candidate Chemotherapy Agents

Many cancer patients are prescribed drugs to which their cancer is already resistant - and thus suffer toxicity with no potential for benefit. Previous attempts to assess chemoresistance or sensitivity in vitro have failed. This is a feasibility study in human patients with newly diagnosed or recurrent lymphoma to determine how human cancerous lymph nodes in situ respond to standard of care therapeutics precisely microinjected with the CIVO(tm) microdosing system.


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or over
* Has enlarged lymph node(s) highly suspicious of lymphoma; or has been diagnosed with lymphoma but is untreated; or has persistent recurrent, or progressive lymphoma
* At least one enlarged lymph node that is considered accessible for percutaneous injection by the investigator and that is at least 2 cm in longest dimension.
* ECOG performance status of 0-2 (or a Karnofsky performance status of \>50%).
* Labs required for enrollment: Absolute neutrophil count \> 1000/mm3, platelet count \> 50,000/mm3, hematocrit \> 25%, creatinine \<3.0 mg/dl, total bilirubin \<4.0 mg/dl, SGOT and SGPT less than five times the institutional upper limits of normal.

Exclusion Criteria:

* Lymphoma patients in which the delay of surgery until the lymph node resection date or other factors associated with the study are not feasible.
* Patients with central nervous system disease.
* Any therapy that is potentially immunosuppressive or has anticancer activity in the 4 weeks prior to device microinjection.
* Patients with active fungal, viral, or bacterial infections
* Pregnant women.
* Inability to give informed consent.
VCSIP Follow-up Study

The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function and decrease wheeze at 5 years of age in their offspring. This is a continuation of the VCSIP trial, to follow the offspring through 5 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's PFTs and decrease the incidence of wheeze.

The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function and decrease wheeze at 5 years of age in their offspring. This is a continuation of the VCSIP trial, to follow the offspring through 5 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's PFTs and decrease the incidence of wheeze. The reasons for this protocol are to follow the children born to mothers randomized in the VCSIP to the age of 5 to differentiate the patients with transient versus recurrent wheeze (and therefore more likely to develop asthma); to determine if early protective effects of vitamin C are sustained to this older age; and to continue to collect biologic samples from the children for future mechanistic studies of vitamin C action.

The primary aim of this study is to demonstrate improved pulmonary function at 5 years of age in the offspring of pregnant smokers randomized to vitamin C (500 mg/day) versus placebo. The investigators hypothesize that vitamin C supplementation in pregnancy will block the adverse effects of maternal smoking on offspring pulmonary function measured at 5 years of age by spirometry. Impulse oscillometry (IOS) will also be used at 3-5 years of age to assess pulmonary function.

Specific Aim 2 (Secondary Outcome): The secondary aim of this study is to demonstrate a decreased incidence of wheeze at 5 years of age in offspring of pregnant smokers randomized to vitamin C (500 mg/day) versus placebo. The investigators hypothesize that vitamin C supplementation during pregnancy will decrease the incidence of wheeze at 5 years of age in offspring of smokers. Respiratory health will be assessed by quarterly validated respiratory questionnaires and clinician report.

Eligibility Criteria:
Inclusion Criteria:

* Women and their offspring randomized to vitamin C versus placebo during pregnancy as well as pregnant nonsmokers and their offspring enrolled as the reference group in the current RCT.

Exclusion Criteria:

* Patients specifically withdrawing consent.
Survey to Assess Why People Are Not Responding to Treatment in Hypertension

This study will describe the factors influencing the physician in face of elevated blood pressure in already treated patients


Eligibility Criteria:
Inclusion Criteria:

* Men or women over 18
* Hypertensive patients
* Uncontrolled hypertension (blood pressure \>/=140/90 mmHg on the day of consultation or \>/=130/80 mmHg in diabetic patients or in patients suffering from kidney failure, or in elderly patients with a systolic blood pressure \>/=150 mmHg (in the absence of orthostatic hypotension)
* Patients treated with a combination, fixed or not, of Renin-Angiotensin System Blocker (RASB) + Hydrochlorothiazide (HCTZ)
* Patients examined in common medical care practice, whatever the reason for consultation
* Patients informed of the study
Postmarketing Surveillance Study of Berotec® N 100 µg Metered-dose Inhaler in Chronic Obstructive Respiratory Tract Disease

Study to obtain data about changing from the chlorofluorocarbon (CFC) - containing Berotec® 200 µg metered - dose inhaler to the CFC - free Berotec® N 100 µg metered - dose inhaler


Eligibility Criteria:
Inclusion Criteria:

* Patients were included in the study only if they had been treated with Berotec® 200 µg metered - dose inhaler before switching to the CFC-free Berotec® N 100 µg metered - dose inhaler

Exclusion Criteria:

• Contraindications listed in the Instructions for Use/Summary of Product Characteristics for Berotec® N 100 µg metered - dose inhaler
Safety Study of EMD 72000 in Combination With ECX (Epirubicin, Cisplatin and Capecitabine) in Oesophagogastric Cancer

The main purpose of this study is to test the safety and tolerability and effectiveness of a new treatment, EMD 72000 (matuzumab), for advanced oesophagogastric cancer in combination with the chemotherapy regimen ECX (epirubicin, cisplatin and capecitabine).

In addition the study will look at pharmacokinetic (how the the body takes up the drug) and pharmacodynamic parameters (what the drug does in the body).


Eligibility Criteria:
Inclusion Criteria:

* Advanced, recurrent or metastatic gastric adenocarcinoma or adenocarcinoma of the lower third of the esophagus
* EGFR positive tumor
* KPS greater than 60
* Normal cardiac function
* Adequate liver and bone marrow function
* GFR greater than 60 ml/minute

Exclusion Criteria:

* Previous chemotherapy
* Uncontrolled angina pectoris, heart failure, clinically significant uncontrolled cardiac arrythmias
* Clinically significant ECG or cardiac history
* Radiotherapy or surgery within last 4 weeks
Tübingen High Altitude Ophthalmology Study

Tuebingen High Altitude Ophthalmology Study to investigate the effects of high altitude on retinal structure and function as well as anterior chamber in regard to acute mountain sickness.


Eligibility Criteria:
Inclusion Criteria:

* healthy subjects, non-smokers, physical fitness,

Exclusion Criteria:

* ocular pathologies, ascent above 2000m 2 weeks prior to study and 2 weeks before post-examination