cyrilzakka/clinical-trials huggingface dataset:
Precision Allergy: Separate Allergies to Male and Female Dogs

A new male-specific dog-allergen-component has been found (Can f 5) which indicates possible differences in allergic reactions to male and female dogs. This has not yet been tested in real life.

The aim is to test if sensitization only to the male-dog specific allergen-component, Can f 5, results in a positive skin prick test (SPT) to male dog extract and not female dog extract. In addition, the investigators want to investigate if allergic symptoms only occur when exposed to the male dog extract by conjunctival provocation.


Eligibility Criteria:
Inclusion Criteria:

* Participants in the COPSAC 2000 cohort
* Positive component test (\>0.3 ISU) to Can f 1, Can f 2, Can f 3 or Can f 5

Exclusion Criteria:

* Uncontrolled asthma
* Eye-surgery within the past 6 months
* Antihistamine allergy
* and others
Evaluating Intercostobrachial Nerve Block's Effect on Pain Control After Shoulder Replacement

Interscalene blocks are frequently performed to decrease postoperative pain after shoulder surgeries and are considered the gold standard for pain control after this type of surgery. Some patients report pain in the axilla (armpit) following shoulder replacement surgeries. Sensation in the axilla is supplied by nerves not covered by the interscalene block. Sensation in the axilla can be decreased by performing an intercostobrachial nerve block. This study aims to study whether adding an intercostobrachial nerve block to the interscalene block decreases recovery room stay time, opioid pain medication requirement, and postoperative pain scores.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients 18-80 years old
* Adult patient's BMI \<= 35
* Individuals presenting for primary total shoulder arthroplasty or reverse total shoulder arthroplasty
* Anticipated discharge home same day of surgery
* Patient is able to provide informed consent to participate in the study.

Exclusion Criteria:

* Patient presenting for revision shoulder surgery
* Allergy to amide local anesthetic, liposomal bupivacaine or other medication involving liposomal formulation
* Preexisting neurological deficits involving or potentially involving the ipsilateral brachial plexus
* Preexisting contralateral vocal fold paralysis or recurrent laryngeal paralysis
* Psychiatric or cognitive disorders that could interfere with perioperative evaluation including drug or alcohol abuse
* Chronic pain conditions
* Preoperative opioid use
* Moderate to severe pulmonary disease
* Moderate to severe sleep apnea
* Planned postoperative admission.
* Unplanned postoperative admission
* Any contraindication to interscalene or intercostobrachial nerve block including any local disorder of the skin where blockade is to be performed which would prevent safe performance of the block
* Any coagulation abnormality which would be a contraindication for block placement
* Preoperative chronic renal dysfunction requiring renal replacement therapy or CrCl \< 60
* Sulfa allergy (or other reason patient cannot receive celecoxib)
* Allergy or intolerance to any medication in the protocol
* Body mass index \>35
* Pregnancy
* Incarceration
* ASA classification greater than 3
* Inability to provide informed consent
* Refusal to participate in the study
Studying Cognition in SPG4

Comparing the cognitive levels of patients with SPG4 mutations to healthy controls.

Comparing the cognitive levels of patients with SPG4 mutations to healthy controls by using the CANTAB® and MoCA.

Eligibility Criteria:
Inclusion Criteria:

* Patient with SPG4 with known SPAST-Mutation (patient group) or healthy control
* Age 18 to 70 years
* Written, informed consent

Exclusion Criteria:

* Lack of ability for a written, informed consent
* Presence of gait disorder or other neurological condition (for healthy controls)
Intraoperative Hypotension Predicted by Mean Arterial Pressure

During general anesthesia, intraoperative hypotension (IOH) is associated with increased morbidity and mortality. Mean arterial pressure (MAP) \< 65mmHg is the most common definition of hypotension. In order to reduce IOH, a complex method using machine learning called hypotensive prediction index (HPI) was shown to be superior to changes in MAP (ΔMAP) to predict hypotension (MAP between 65 and 75 excluded). Linear extrapolation of MAP (LepMAP) is also very simple and could be a better approach than ΔMAP. The main objective of the present study was to investigate whether LepMAP could predict IOH during anesthesia 1, 2 or 5 minutes before.

Hypothesis : the area under the ROC curves (ROC Area Under Curves) at 1, 2 and 5 minutes of LepMAP would be superior to ΔMAP


Eligibility Criteria:
Inclusion Criteria:

* All lobectomy including for another study (VATOFA study) with continuous invasive blood pressure monitoring per arterial line
* All pancreaticoduodenectomy or hepatectomy including for another study (CARBODAV study) with continuous invasive blood pressure monitoring per arterial line
* age 18 or over

Exclusion Criteria:

* complex hemodynamic cases (heart, lung and liver transplantation)
* using extracorporeal membrane oxygenation.
* Patient who object to take part of the study.
Effect of Simulation on PALS Training

Patient simulation is a new and expanding technology that has proven effective as a teaching tool in various clinical settings, but data on pediatric simulation is lacking. Mock resuscitation scenarios have been shown in prior studies to be effective for improving knowledge, skill, and confidence in pediatric housestaff. Our objective is to assess the utility of a training program utilizing a human patient simulator of an infant as a teaching tool for pediatric housestaff training in resuscitation skills. We hypothesize that mock resuscitation exercises performed by pediatric housestaff on a patient simulator will result in improved performance on test scenarios when compared to the same training on a standard manikin.

Patient simulation is a new and expanding technology that has proven effective as a teaching tool in various clinical settings, but data on pediatric simulation is lacking. Mock resuscitation scenarios have been shown in prior studies to be effective for improving knowledge, skill, and confidence in pediatric housestaff. Our objective is to assess the utility of a training program utilizing a human patient simulator of an infant as a teaching tool for pediatric housestaff training in resuscitation skills. We hypothesize that mock resuscitation exercises performed by pediatric housestaff on a patient simulator will result in improved performance on test scenarios when compared to the same training on a standard manikin.

We propose a randomized trial of pediatric residents of identical training levels from three children's hospitals. Participants will be assigned to a control group or an intervention group. The control group will undertake mock resuscitation scenarios on a standard manikin; the intervention group will perform the same exercises on a simulator. A test scenario will be administered at the end of each set of training scenarios and frequency and timing of a predetermined list of critical clinical assessments and interventions will be recorded. Analysis will consist of a comparison between control and intervention groups for success rates and time to completion for clinical assessments and interventions.

Eligibility Criteria:
Inclusion Criteria:

* PGY 1 or 2 in pediatrics at CHOP, St. Christopher's Hospital for Children, or A.I. DuPont Hospital for Children
To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa

The trial is a 12-week phase 2 study. Subjects will be given subcutaneous injections at weeks 0 (160mg), 2 (80mg), and then every other week (40mg) until week 12 in subjects with moderate to severe hidradenitis suppurativa.


Eligibility Criteria:
Inclusion Criteria:

Subjects with moderate to severe HS as defined by a HSSI \> 8 AND at least ONE of the following:

1. HS \>1 year duration with multiple ER or doctors visits related to HS
2. Intralesional kenalog injection \>5/year, however none within 2 weeks of entry
3. Failed systemic retinoids, but not within 3 months of entry
4. Failed at least one prior course of antibiotic therapy, which must not have been administered within 2 weeks of entry to the study (excluding the recommended antibiotic regimen given for evidence of active infection immediately before enrollment)
5. History of surgery (reconstructive), but not within 3 months of entry

Exclusion Criteria:

1. Women who are pregnant, nursing, or planning pregnancy within 6 months after the last injection (this includes father's who plan on fathering a child within 6 months after their last injection).
2. Use of other systemic anti-inflammatory medication except NSAIDs and low dose systemic steroids (equal or less than 10 mg daily prednisolone or equivalent).
3. If found to have an active infection, patients must have completed topical or oral antibiotic therapy at least 7 days before first injection.
4. Have a known history of serious infections (e.g., hepatitis, pneumonia or pyelonephritis) in the previous 3 months.
5. Have or have had an opportunistic infection (e.g., herpes zoster \[shingles\], cytomegalovirus, Pneumocystis carinii, aspergillosis, histoplasmosis, or mycobacteria other than TB) within 6 months prior to screening.
6. Have a history of lymphoproliferative disease, including lymphoma or signs suggestive of possible lymphoproliferative disease such as lymphadenopathy of unusual size or location (e.g., nodes in the posterior triangle of the neck, infraclavicular, epitrochlear, or periaortic area), or splenomegaly.
7. Have a concomitant diagnosis or history of congestive heart failure.
8. Have a history of latent or active granulomatous infection, including TB, histoplasmosis, or coccidioidomycosis, prior to screening.
Our Lifestyles Our Lives

The purpose of the study was to examine the influence of step goals with pedometers to improve children's weight loss, physical activity, and psychosocial health during behavioral treatment. Children with overweight or obesity were assigned to receive the behavioral treatment alone, plus pedometers, or plus pedometers with step goals.

A total of 105 overweight and obese children ages 8 to 17 years participated in a 10-week family-based weight management intervention focusing on physical activity, nutrition, and behavioral modification. A quasi-experimental design was used to group cohorts into three conditions: two cohorts had no pedometer (n=24); two cohorts had pedometer only (n=25); and four cohorts had pedometer with step goals (i.e. 500 steps/day weekly increase above baseline; n=56). Height and weight were measured at baseline and week 10 and used to calculate body mass index (BMI). Analysis of covariance was performed to examine difference by condition for change in weight, BMI, and BMI z-score, controlling for age and baseline value. Differences in steps/day and psychosocial health were compared between the two pedometer conditions.

Eligibility Criteria:
Inclusion Criteria:

* Aged 8-17 years old
* BMI ≥ 95th percentile or have a BMI ≥ 85th percentile with comorbidities (e.g. hypertension, heart disease, type 2 diabetes, insulin resistance, sleep apnea, orthopedic problems, or fatty liver disease)

Exclusion Criteria:

* None.
Functional Connectivity Parkinson Disease

In this study the investigators are looking at two subtypes of Parkinson Disease (PD); "tremor-dominant" (TD) and postural imbalance and gait disorder (PIGD). This study will use magnet resonance imaging (MRI) to see how the brain reacts while resting and doing a finger-tapping task while on and off PD medication. This study will look at the differences between the two sub-types of PD and healthy volunteers.

The investigators will test the hypothesis that connectivity at rest within the motor cortex and between the motor cortex and motor-associated regions such as the supplementary motor area and the pre motor cortex will not be as strong in PIGD compared to TD (increased activity and functional connectivity in TD group)


Eligibility Criteria:
Inclusion Criteria:

* English as their primary language
* Patients with Parkinson disease and healthy controls will be enrolled
* Parkinson patients must be on a dopaminergic medication (levodopa or dopamine agonist) and on a stable dose over the prior month

Exclusion Criteria:

* If unable to provide informed consent
* Pregnancy
* Excess of 300lbs
* Claustrophobia
* Metal in body
* Untreated neurological or psychiatric condition, who are delusional or have hallucinations, with cognitive impairment (MOCA\<26), with a history of head injury sufficient to cause a concussion, or with significant systemic medical diseases (e.g. heart failure, liver failure, kidney failure, poorly controlled diabetes, etc.)
* Healthy control subjects will be excluded if taking any type of dopaminergic or anti-dopaminergic medication
* Subjects who are unable to demonstrate understanding of the study procedures and risks will be excluded
Peripheral Oxygen Saturation (SpO2) Directed Oxygen Therapy

Investigators hypothesized that a relative low SpO2 directed oxygen therapy would reduced the mortality in patients staying longer than 72 hours in ICUs.

In fear of harmful effect of hypoxia, oxygen therapy is commonly used, especially in critically ill patients in intensive care units (ICUs). However, hyperoxia can be harmful too. Examples are myocardial infarction (MI) patients and patients resuscitated to return of spontaneous circulation after cardiac arrest. In Air Versus Oxygen in Myocardial Infarction (AVOID) trial, Meyhoff and colleagues proved hyperoxia caused more cardiac injury in patients with ST-elevation MI but without hypoxia. Kilgannon and colleagues found that arterial hyperoxia following resuscitation from cardiac arrest were associated with increased in-hospital mortality, and a pulse oxygen saturation (SpO2) of 94-98% was recommended.

Recently, Panwar and colleagues found that compared to liberal oxygen strategy (SpO2 ≥96%), conservative oxygen strategy (SpO2 of 88%-92%) was feasible in patients receiving invasive mechanical ventilation. Girardis and colleagues found control oxygen therapy (targeting SpO2 of 94%-98% or PaO2 of 70-100mmHg) resulted lower ICU mortality than conventional oxygen therapy (SpO2 ≥97%) in the randomized clinical trial called Oxygen-ICU. However, the Oxygen-ICU trial was single-centered, early-terminated with only 480 patients included and led to an unplanned interim analysis. In this larger multicenter trial, investigators hypothesized that a relative low SpO2 directed oxygen therapy was safe and would reduced the 28-day mortality in patients staying longer than 72 hours in ICUs.

Eligibility Criteria:
Inclusion Criteria:

* aged 18 years or older and admitted into ICU, with expected stay in ICU more than 72 hours or longer.

Exclusion Criteria:

* under 18 years old, expected stay in ICU less than 72 hours, unconsented inclusion, ICU readmission, patients with acute exacerbation of chronic obstruction disease, patients with severe acute respiratory distress syndrome (defined as PaO2/FiO2 ≤ 100mmHg and PEEP ≥10cmH2O), decision to withhold life-sustaining treatment, physician forgetting to screen during 12 hours after admission, pregnancy, patients with acute myocardial infarction, paraquat poisoning and patients on extracorporeal membrane oxygenation (ECMO) or planned to be on ECMO.
Rotator Interval and Intra-articular Corticosteroid Injection for Frozen Shoulder

The purpose of this study is to compare ultrasound guided capsular corticosteroid injection into the rotator interval/anterior capsule and the GH joint with ultrasound guided corticosteroid injection into the GH joint only. Both methods will be compared with placebo injections.

Primary outcome measure: pain reduction at week 6 Secondary outcome measures: improvement of function (SPADI, Life quality, ROM).

0-hypothesis: no difference between the methods.

The investigators want to find out if the clinical effect of the combined capsular and intra-articular injections are better than placebo and better that intra-articular injections

3 groups, 50 patients in each, follow-up visits after 3, 6, 12 and 26 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Pain and stiffness in one shoulder 1 - 6 months
* Restriction of passive ROM; \>= 30 degrees in two or more planes compared to other shoulder

Exclusion Criteria:

* Systemic inflammatory disease
* Corticosteroid treatment last 3 months
* Poorly controlled Diabetes mellitus
* Pregnancy
* Contraindications/allergy to corticosteroids and/or Lidocaine
* Severe infections
* Osteoarthritis of the shoulder
* Fractures of the shoulder
* Rotator cuff pathology causing pain or disability
* Fibromyalgia
* Not able to understand Norwegian
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia

This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.

Data collected during this research study will help electrophysiologists and anesthesiologists to make the best decisions about the best anesthetic conditions to use to perform VT ablations.

This research study is a "pilot" study. Pilot studies are done on a small group of subjects to learn if a larger study would be useful.


Eligibility Criteria:
Inclusion Criteria:

* Patients with VT and have an implanted ICD who are scheduled for VT catheter ablation.
* Patients 18 years of age or older

Exclusion Criteria:

* Patients with difficult airway management or patients with contra/ relative contra indication for general anesthesia or known allergies to any of the proposed anesthetic agents
* Women who are pregnant
Propolis In The Treatment Of Periodontitis

This study was conducted to evaluate by clinical and microbiological parameters the effect of locally delivered propolis as an adjunct to scaling and root planing in the treatment of chronic periodontitis.

Materials and Methods: 20 subjects diagnosed with chronic periodontitis were recruited to participate in split-mouth design and provided informed consent. Subgingival plaque sampling and clinical recording at baseline, 15 days and 1 month was performed. The patients received scaling and root planing, followed by Propolis administration subgingivally in the test sites. Significant differences between test and control were evaluated using the Mann-Whitney U test and Wilcoxon rank test.

Eligibility Criteria:
Inclusion Criteria:

* good general health
* chronic periodontitis
* minimum of 20 natural teeth with at least one pocket per quadrant
* probing depth (PD) between 5 and 8 mm.

Exclusion Criteria:

* subgingival instrumentation within 3 months
* antibiotic therapy within 3 months prior to the start of the study;
* smokers
* pregnant or nursing women
* intolerance or allergy to honey products
A Study of the Safety, Effectiveness and Clinical Use of Maviret in Adolescent Patients With Chronic Hepatitis C Virus

This study will assess the safety and effectiveness of Maviret (Glecaprevir plus Pibrentasvir (GLE/PIB)) in adolescent participants diagnosed with chronic hepatitis C (CHC) in a real world setting across clinical practice in Japan.


Eligibility Criteria:
Inclusion Criteria:

* Chronic Hepatitis C Virus (HCV) infection treated in daily practice with Maviret
* Enrolled after Maviret treatment begins
* Prior treatment with Maviret

Exclusion Criteria:

None
A Study to Evaluate the Efficacy and the Change of sAg Levels in Chronic Hepatitis B Patients Receiving Clevudine Treatment Over the Long Period

The purpose of this study is to evaluate the efficacy and the Change of sAg Levels in Chronic Hepatitis B Patients Receiving Clevudine Treatment Over the Long Period.


Eligibility Criteria:
Inclusion Criteria:

1. Patient is 18 years and older.
2. Patient is documented to be HBsAg positive for \> 6 months and HBV DNA positive.
3. Patient is HBeAg positive or negative.
4. Patient has ALT levels ≥ 80 IU/L
5. Patient who is able to give written informed consent prior to study start and to comply with the study requirements.

Exclusion Criteria:

1. Patient is currently receiving antiviral, immunomodulatory, cytotoxic or corticosteroid therapy.
2. Patients previously treated with interferon within the previous 3 months.
3. Patients previously treated with clevudine, lamivudine, adefovir, entecavir, telbivudine or any other investigational nucleoside for HBV infection.
4. Patient is coinfected with HCV, HDV or HIV.
5. Patient is pregnant or breast-feeding.
6. Patient has a clinically relevant history of abuse of alcohol or drugs.
7. Patient has a significant immunocompromised, gastrointestinal, renal, hematological, psychiatric, bronchopulmonary, biliary diseases excluding asymptomatic GB stone, neurological, cardiac, oncologic(except HCC)or allergic disease or medical illness that in the investigator's opinion might interfere with therapy.
8. Patient has creatinine clearance less than 60mL/min as estimated by the following formula: (140-age in years) (body weight \[kg\])/(72) (serum creatinine \[mg/dL\]) \[Note: multiply estimates by 0.85 for women\]
Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance - Impact on Outcome

In acute myocardial infarction cardiovascular magnetic resonance imaging can retrospectively detect the myocardium at risk and the irreversible injury. This allows for quantifying the extent of salvaged myocardium after reperfusion as a potential strong end point for clinical trials and outcome. The aim of the present study is to determine the prognostic significance and determinants of myocardial salvage assessed by CMR in reperfused ST-elevation myocardial infarction (STEMI).


Eligibility Criteria:
Inclusion Criteria:

* ST-elevation myocardial infarction \< 12 hours
* primary percutaneous coronary intervention

Exclusion Criteria:

* previous myocardial infarction
* prior fibrinolysis
* contraindications to CMR at study entry (such as implanted pacemakers, defibrillators, claustrophobia or metallic intracranial implants)
Detailed Evaluation of Microchimerism

Individuals who experience traumatic injury often require blood transfusion. In some individuals who receive blood after an injury, white blood cells from a person who donated blood may remain in the body for years, a condition known as microchimerism. This study is designed to examine a group of people who are known to have long-term microchimerism and, through analysis of their blood, determine whether there is evidence that the microchimerism involves blood stem cells that can become any type of blood cell (red blood cells, white blood cells, or platelets) and that might be a permanent part of the body.

Transfusion-associated microchimerism, the persistence of donor white blood cells months or years after transfusion in the recipient, has been observed in approximately 10-15% of transfused trauma patients. Previous studies suggest that the microchimeric cells include multiple immunophenotypes of leukocytes (CD4+, CD8+, CD15+, and CD19+) and that they can persist for decades, features suggestive of hematopoietic engraftment.

In this study, ten subjects known to have long-term microchimerism will undergo either leukapheresis (a blood filtering procedure) or collection of a 500 mL whole blood sample (the amount of a standard blood donation). These samples will then be analyzed to determine whether the microchimeric (donor) cells include hematopoietic stem cells (CD34+) and precursor cells in the red blood cell, white blood cell, and platelet lineages.

Eligibility Criteria:
Inclusion Criteria:

* Demonstrated long-term microchimerism following transfusion for traumatic injury

Exclusion Criteria:

* Prior bone marrow or solid organ transplantation
* Pregnancy
* Blood transfusion within the past 12 months