cyrilzakka/clinical-trials huggingface dataset:
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19

Patients with COVID-19 and comorbidities including alcohol associated liver disease (ALD) are at risk for severe illness and abrupt or sudden clinical deterioration with ventilatory failure. â-hydroxy â-methyl butyrate (HMB), a non-nitrogenous leucine metabolite with anabolic properties, increases muscle mass and contractile function and enhances immune function. We aim to study the natural course of COVID-19 in patients with ALD and test whether HMB can affect ventilatory deterioration and improve short and long-term morbidity, mortality, and recovery from critical illness in symptomatic COVID-19 patients with ALD.


Eligibility Criteria:
Inclusion Criteria:

A. Cases: Patients with ALD and COVID-19 pneumonia:

1. Clinical, imaging, laboratory, and/or histological diagnosis of alcoholic cirrhosis and/or alcoholic hepatitis
2. Child Pugh score 5-8, serum creatinine \<3, Model for End Stage Liver Disease score (MELD) \<25
3. Diagnosis of COVID-19 pneumonia as defined by the WHO criteria: confirmed SARS-CoV-2 infection by PCR, evidence of bilateral pulmonary infiltrates on chest radiograph (CXR) or computed tomography (CT) and SpO2 \<93% or on oxygen supplement
4. Age of 21 years or older

B. Controls: Patients without alcoholic liver disease (Non-ALD) and COVID-19 pneumonia:

1. Diagnosis of COVID-19 pneumonia as defined by the WHO criteria: confirmed SARS-CoV-2 infection by PCR, evidence of bilateral pulmonary infiltrates on chest radiograph (CXR) or computed tomography (CT) and SpO2 \<93% or on oxygen supplement
2. Age of 21 years or older

Exclusion Criteria: (Both Cases and Controls)

1. Patients requiring active ventilator support
2. Anticoagulant/antiplatelet therapy (for those in the biopsy arm, see Randomization schema. If clinically feasible, patients will be asked to hold their anticoagulants for the muscle biopsy after physician review),
3. Recent gastrointestinal bleeding (\<3 months)
4. Advanced organ diseases: congestive heart failure (NYHA class 3 and 4), chronic obstructive pulmonary diseases (COPD) (GOLD stage 3 and 4), chronic kidney disease (Cr\>3), metastatic malignancy
5. Medications that alter muscle protein metabolism except systemic corticosteroids
6. Pregnancy
7. Unwillingness/ Inability to sign informed consent
MoCA vs. MMS: Which Tool to Detect Cognitive Disorders in Oncogeriatric?

This study concerns elderly patients with cancer with onco-geriatric assessment.

This study propose to associate the collection of the results with the Mini-Cog and the CODEX with the passing of the MoCA and the MMS tests, as well as a neuropsychological assessment, in order to determine if the patients have cognitive impairments, to evaluate the sensitivity of these 4 screening tests in elderly patients seeking treatment for their cancer. The results of this study will make it possible, where appropriate, to adapt the practice in the context of oncogeriatric assessment.


Eligibility Criteria:
Inclusion Criteria:

* Patient aged over 70 years
* Patient with cancer (solid tumor or haemopathy) for whom a first line treatment is envisaged (whatever it is). Surgery and radiotherapy are allowed before entry into the study.
* Patient candidate for oncogeriatric assessment
* Patient agree to participate in the study
* Using the French language

Exclusion Criteria:

* Primary central nervous system or cerebral metastasis
* Evolutionary psychiatric pathology known (e.g. schizophrenia)
* Severe Visual and / or Auditory Impairment
* Patients unable to respond to cognitive tests
* Patient (s) deprived of liberty, under guardianship or curatorship
* Refusal of participation
The Effect of Core Stability Exercises on Idiopathic Scoliosis in Adolescent Females

To evaluate the efficacy of core stability (CS) exercises on curve magnitude, posture, trunk deformity and quality of life in adolescent females with idiopathic scoliosis.

Scoliosis is a disease in which the spine deviates or rotates laterally from its normal vertical line, and it can cause decreased spinal movement, weakening of muscles near the spine, reduced pulmonary function, respiratory dysfunction, chronic pain, and psychological suffering. Scoliosis can be classified as idiopathic, congenital, neurofibromatosis, and neuromuscular. Among these types of scoliosis, approximately 80% of patients with scoliosis have AIS, which typically occurs around 10 years of age when healthy bone maturation occurs during adolescence. IS is diagnosed when there are no known causes besides spinal deformity involving a lateral curvature with a Cobb angle ≥10°.

Therapeutic approaches for IS include surgical and conservative treatments. Exercise therapy for IS is considered important for maintaining spinal function when the Cobb angle is \<20°. Moreover, the effects of core stabilization exercise have been demonstrated recently for alleviating chronic lower back pain in patients, improving performance in athletes, and preventing sports injuries in athletes. Based on this information, core stabilization exercise may be used effectively to improve neuromuscular imbalance, which is the cause of IS. However, studies on the therapeutic effects of using core stabilization exercise in patients with AIS are still lacking.

Accordingly, the objective of this study is to evaluate the efficacy of core stability exercises on curve magnitude, posture, trunk deformity, and quality of life in adolescent females with idiopathic scoliosis.

Eligibility Criteria:
Inclusion Criteria:

* Their ages will be ranged from 10-19 years.
* All adolescent Females will be diagnosed as idiopathic scoliosis with S shape.
* Cobb angle on anterior-posterior radiograph will be used in the assessment of thoracic and lumbar cure of each patient in this study.
* All adolescent females are not under any other treatment method for idiopathic scoliosis.
* Willingness and ability to comply with the study requirements and give informed consent.

Exclusion Criteria:

* Patients with a history of rheumatologic, neuromuscular, cardiovascular, pulmonary, or renal diseases.
* Patients with congenital scoliosis or spinal deformity.
* Patients who had undergone surgical correction of the spine.
* Patients with a tumor.
* Enrollment in any other clinical trial during the time of this trial.
Restoring Non-Emergent Cardiovascular Care in the Peri- COVID-19 Era

Pre-procedure and Short-Term COVID-19 Testing of Outpatients Undergoing Non-emergent Invasive Cardiovascular Procedures


Eligibility Criteria:
Inclusion Criteria:

• Outpatients undergoing non-emergent invasive cardiac diagnostic, cardiac interventional, peripheral diagnostic, peripheral interventional, structural heart interventional, electrophysiology diagnostic, ablation, or device implantation procedures

Exclusion Criteria:

* Previous positive COVID-19 test result
* Patients with symptoms concerning for COVID-19, including (but not limited to):

Fever \> 38˚C, shortness of breath and/or cough in greater severity from baseline, sore throat, anosmia / dysgeusia, vomiting/diarrhea within 24 hours prior to procedure

* Emergent status including (but not limited to) acute coronary syndromes, acute limb ischemia, stroke, need of temporary pacemaker
* Non-outpatient status including (but not limited to) patients evaluated in the hospital, observational unit, or emergency department
Physical Activity Centers Empowerment

This research study tests the feasibility of the Physical Activity Centers Empowerment (PACE) physical activity intervention for African American individuals diagnosed with colorectal cancer.

Feasibility will be measured as intervention reach, effectiveness, adoption, implementation, and maintenance. Seventy-two subjects will be recruited to conduct a pilot two-group, randomized repeated measures study.

The purpose of this research is to improve the quality of life for underserved cancer survivors by increasing physical activity. A physical activity intervention will be tested for feasibility with African American cancer survivors. The project will serve as a foundation for intervening with other underserved cancer survivors.

Feasibility will be measured as intervention Reach, Effectiveness, Adoption, Implementation, and Maintenance, following the RE-AIM framework. Survey and biomarker data will be collected at baseline, 3 and 9 months later. These time points will facilitate exploration of changes pre- and post-intervention, and to determine if effects are maintained 6 months after completing the intervention. Our primary hypothesis is that the intervention will be feasible to deliver.

Eligibility Criteria:
Inclusion Criteria:

1. self-identifying as AA of Black,
2. diagnosis of CRC,
3. scheduled to receive chemotherapy,
4. age 18 years or older,
5. no contraindications to unsupervised PA as determined by the PA readiness questionnaire,
6. oncologist approval to participate, and
7. a smartphone for Fitbit syncing.
Predicting Independent Walking Ability Using the Simplified Stroke Rehabilitation Assessment of Movement, Berg Balance Scale, Barthel Index for Activities of Daily Living in Individuals Post Stroke

Cohort observational retrospective pilot study by design. The purpose of this study was to determine a cut scores to predict independent ambulation for the Simplified Stroke Rehabilitation Assessment of Movement, Berg Balance Scale, Barthel Index for Activities of Daily Living.


Eligibility Criteria:
Inclusion Criteria:

* Male or female patients with stroke after the age of 17 confirmed stroke by neuroimaging, understanding instructions, time after stroke up to 1 year.

Exclusion Criteria:

* Subjects were excluded if they have: the presence of aphasia that would have interfered with the participant's ability to understand and comply with study procedures or complete stroke assessments, dementia, ataxia, localization of stroke in the cerebellum or vertebrobasilar insufficiency, orthopedic problems that affected the ability to walk before the stroke and time after stroke more than 1 year.
Gene Polymorphism of IL17 and IL 23

rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins. These pleiotropic cytokines are secreted at the region of inflammation and released into the circulation by a variety of different cell types, including macrophages, lymphocytes, endothelial cells, epithelial cells during sepsis and acute organ injuries. There has recently found a number of studies reporting that the cytokine storms take part in the course of COVID-19

Aim Of The Study

1. To evaluate if there is an association between the IL-17, IL-23 gene polymorphism in Patients With COVID 19 by real-time PCR
2. To measure the serum level of IL17 by ELISA in COVID 19 patients by ELISA.
3. To detect if there is an association between gene polymorphism of IL17 and IL23 and severity of a condition in patients with COVID 19 Study design: a cross-sectional study.

The blood samples will be collected from patient records in COVID19 isolation hospitals in sohag governorate and isolation department in sohag university hospitals.

Eligibility Criteria:
Inclusion Criteria:

* Patients with Covid19 positive PCR

Exclusion Criteria:

* Patients with Covid19 clinical criteria not confirmed by PCR
Different Immunochemotherapies in Small B-cell Non-Hodgkin Lymphoma (iNHL)

Describe the application status of different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL), observe the therapeutic efficacy and safety of the treatment modalities.

Evaluated the efficacy and safety of different immunochemotherapies in small B-cell non-Hodgkin lymphoma (iNHL)

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years old
* Initial or first recurrent iNHL confirmed by histopathology, including FL (1-3a), MZL, MCL;
* Sign an informed consent form;
* Researchers evaluate patients who can benefit from receiving immunochemotherapy.

Exclusion Criteria:

* There are contraindications to any medication in the treatment plan;
* Pregnant or lactating women or male and female participants of childbearing age did not take contraceptive measures during the trial period and within 30 days after the last medication;
* Researchers believe that patients who are not suitable for enrollment.
Connection of Body Posture From the Level and Form of Physical Activity in a Group of Young People

The assumption of the research is to assess the change in body posture depending on the given level of physical activity in young people. The aim of the study is to assess body posture in young healthy people depending on their level of physical activity. The research will allow the analysis of the correlation between the level of energy expenditure and the occurrence of changes in body posture. The obtained results will allow the development of diagnostic and therapeutic programs for the prevention of overload changes in the spine in young people.

The study will be conducted in a group of 200 people aged 19-25. Posture assessment will concern the measurement of curvatures in the sagittal plane of the spine using a gravitational Rippstein plurimeter and performing a three-dimensional analysis of the spine using the DIERS 3D device. In addition, a modified Matthias test will be performed using the DIERS 3D device, where kyphosis and lordosis parameters in the sagittal plane of the spine at isometric tension of the spinal muscles will be assessed. The spinal motion in the sagittal and frontal planes will also be measured using a digital inclinometer. In the second stage of the study, the participants will participate in the activity in the form of endurance training "Nordic Walking" (NW) for a period of 8 weeks 3 times a week. The recording of energy expenditure during a normal day of activity will be done using an Actigraph GT3X accelerometer. After a period of 8 weeks, all measurements will be repeated.

Eligibility Criteria:
Inclusion Criteria:

* age from 19 to 25 years old
* good health enabling the exercise of various forms of physical effort -cardiologically stable persons, without significant respiratory, nervous and musculoskeletal disorders / no other diseases
* written consent of the examined person

Exclusion Criteria:

* age below 19 and above 25,
* health condition preventing the exercise of various forms of physical effort (cardiologically unstable persons with significant respiratory, nervous and musculoskeletal disorders / other diseases that prevent physical activity,
* lack of written consent of the examined person,
* lack of cooperation of the examined person during the test
Evaluating the Efficacy and Results of Endoscopic Gastroplasty Performed Using Overstitch in Patients With Obesity.

Obesity is a chronic disease that has grown to epidemic characteristics in Brazil and around the world in recent years. Treatment for patients with class III or class II obesity with comorbidities is already well established, with bariatric surgery being the best option. However, there is no consensus as to the best treatment for cases of class I and class II obesity without comorbidities. The objective of this research will be to make a gastric tube similar to that obtained in surgical gastroplication however it will be created using intragastric endoscopic sutures. The procedures will be performed at the Endoscopy Service of the Mario Covas Hospital in São Paulo, SP. Data collection will be performed at the same location.

The objective of this research will be to make a gastric tube similar to that obtained in surgical gastroplication however it will be created using intragastric endoscopic sutures. The secondary objective will be to correlate demographic, endoscopic and laboratory data with the results of this procedure.

Patients and Methods: Patients with class I obesity with or without comorbidities and patients with class II obesity without comorbidities, irrespective of gender and ethnic background, from the state of São Paulo and other states of the country will be submitted to vertical endoscopic gastroplasty. The procedures will be performed at the Endoscopy Service of the Mario Covas Hospital in São Paulo, SP. Data collection will be performed at the same location.

Information will be obtained during the outpatient follow-up at the Hospital Mario Covas including demographic (gender, age), clinical (height, weight, time after procedure, systemic arterial hypertension, diabetes, dyslipidemia, smoking, alcohol consumption) and operative data (complications).

Preparation for the procedure: All the exams will be performed at the Hospital Mario Covas after the patients have fasted for at least 8 hours. The procedure will begin with the patient in left lateral decubitus under general anesthesia performed by an anesthesiologist. Endoscopic sutures will be performed using 2-0 prolene thread until a tubular-shaped stomach is formed similar to a vertical gastrectomy.

Recovery after the procedure: After the procedure and recovery from anesthesia, all patients will be discharged but only together with a companion. All patients will receive guidance and will remain in touch with a physician to report any adverse signs or symptoms.

Outcomes Primary outcome: To confirm the efficacy of endoscopic sutures in the primary treatment of obesity.

Secondary outcome: To evaluate the use of the endoscopic sutures in relation to demographic data.

Eligibility Criteria:
Inclusion Criteria:

* BMI \> 30 and \< 36 with or without comorbidities
* BMI \> 36 and \< 40 without comorbidities

Exclusion Criteria:

* Prior gastric surgery
* Use of anticoagulants
* Psychiatric disorders
* Severe esophagitis
Experience of Using Lipano in Children With Fatty Acid Oxidation Disorders

This is a market research, observational study to evaluate the tolerability and acceptability of an MCT based formula for infants and young people with long chain fatty acid oxidation disorder from birth to 18 months. Patients with a confirmed diagnosis of a fatty acid oxidation disorder, which requires a specialist diet including MCT will be included in this study


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of a fatty acid oxidation disorder requiring a ketogenic or a specialist diet as part of their treatment, which includes MCT.
* Patients from birth to 18 months
* Written informed consent obtained from patient or parental caregiver

Exclusion Criteria:

* Presence of serious concurrent illness
* Investigator's uncertainty about the willingness or ability of the patient to comply with the protocol requirements
* Participation in any other studies involving investigational or marketed products concomitantly or within two weeks prior to entry into the study.
* Any patients having taken antibiotics over the previous 2 weeks leading up to the study
* Patients over 18 months of age
Electric Stimulation of the Eye to Improve Vision After Trauma

Transcorneal Electrical Stimulation (TES) using the "OkuStim®" device delivers electrical impulses to damaged and/or diseased photoreceptor cells. This electric stimulation of the retina may help to preserve visual acuity and/or the visual field.

The finely detailed, precise anatomy of the retina and optic nerve capture light impulses from the environment through a biochemical process and then transmit these images to the brain via electrical impulses conducted from the inner retina to the optic nerve and ultimately to the occipital cortex.

In the human eye, three types of specialized ganglion cells transmit electrical impulses to the brain. Among these three cell populations are rod and cone cells, which participate in the photo-transduction step of light perception, along with other light sensitive ganglion cells. It is a system whereby the photosensitive pigment rhodopsin (or one of its analogs) rearranges in response to light, and this change in chemical structure fires electrical impulses to the brain which in turn interprets the incoming impulses as a visual image.

Transcorneal Electrical Stimulation (TES) using the "OkuStim®" device delivers electrical impulses to damaged and/or diseased photoreceptor cells. This electric stimulation of the retina may help to preserve VA and/or the visual field.

Eligibility Criteria:
Inclusion Criteria:

* You are 18 years or older.
* You have sustained trauma (more than 3 months before this study) OR been diagnosed with Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) (more than 6 months before this study) OR been diagnosed with Multiple Sclerosis (MS) and suffered visual loss (more than 3 months before this study).
* You are willing and able to give written informed consent.
* You are able to commit to enrolling in the study during the full time period of up to 6 months.

Exclusion Criteria:

* You have any other significant ophthalmologic disease or condition (such as glaucoma, retinal degeneration, proliferative diabetic retinopathy, +/- six diopters of myopia, retinal detachment, exudative age-related macular degeneration).
* You have amblyopia (lazy eye) in affected eye, previously diagnosed.
* You are participating in any other interventional clinical trial.
* If you are pregnant OR a woman with childbearing potential who is unwilling to use medically acceptable means of birth control for study duration OR woman unwilling to perform a pregnancy test at study entry/screening.
* You are unable to give signed consent due to memory, medical, communication, language, or mental health problems.
* You are less than 18 years old.
* You are unable or unwilling to complete the evaluation or questionnaire.
* Visual acuity better than 20/40
* Inability to detect phosphenes during threshold detection
* You are on seizure medications, or have a history of epilepsy.