cyrilzakka/clinical-trials huggingface dataset:
Nutritional Requirement for the Severe Trauma Patients

After severe trauma, high caloric nutrition supplement do harm on metabolic and immunologic aspects.


Eligibility Criteria:
Inclusion Criteria:

* ISS more than 15 score
* older than 20 years old
* patient who need parenteral nutrition more than 5 days

Exclusion Criteria:

* patients who have metabolic disease except for diabetes
* patients who cannot resuscitated
* very low body weight (\< 40kg)
Effect of Botulinum Toxin Type A on Swallowing in Patients With Cervical Dystonia

The purpose of this study is to evaluate swallowing efficiency in patients with cervical dystonia following treatment with botulinum toxin Type A.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with cervical dystonia
* Successfully completed Allergan study MedAff BTX-0616 with 16 weeks since last botulinum toxin Type A injection
* In need of additional botulinum toxin Type A injections

Exclusion Criteria:

* Surgery or spinal cord stimulation for cervical dystonia
* Previous injections of phenol or alcohol for cervical dystonia
Conditional Cash Transfer Intervention to Improve T2DM

This study will test the preliminary efficacy of diabetes-tailored CCT (DM-CCT), which will be conditional on participating in biweekly (every two weeks), nurse-led, virtual diabetes education/skills training and stress/coping intervention compared to UCT (with no requirement for participation) on clinical outcomes, self-care behaviors, and psychological health in 100 inner city AAs with poorly controlled T2DM using an RCT design. The aims of the proposed study include:

AIM 1: Test the preliminary efficacy of the DM-CCT intervention on glycemic control and quality of life for inner-city AAs with T2DM.

AIM 2: Test the preliminary efficacy of the DM-CCT intervention on self-care behaviors and psychological health for inner-city AAs with T2DM.

AIM 3: Estimate the cost of delivery of the DM-CCT and UCT interventions in preparation for future cost effectiveness analysis.

The overarching aim of this proposal is to test the preliminary efficacy of diabetes-tailored CCT (DM-CCT conditional on participating in biweekly, nurse-led, virtual diabetes education/skills training and stress/coping intervention) compared to UCT (with no requirement for participation) on clinical outcomes, self-care behaviors, and psychological health in inner city African Americans with poorly controlled T2DM. One hundred (100) individuals will be randomized to either the DM-CCT intervention or the UCT intervention and followed for 6-months, with study visits at baseline, 3-months, and 6-months. The primary outcomes will be glycemic control (HbA1c) and quality of life (SF-12) at 6-months post randomization. The secondary outcomes will be self-care behaviors (diet, exercise, medication adherence) and psychological health (stress, coping) measured at 6-months post randomization. In preparation for future cost effectiveness studies, the final aim will estimate the cost of delivery of the DM-CCT and UCT interventions.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years
* Self-report as African American
* Clinical diagnosis of T2DM and HbA1c ≥8% at the screening visit
* Residence in inner city zip codes
* Income greater or equal to133% of federal poverty level or Medicaid eligible
* Able to communicate in English.

Exclusion Criteria:

* Mental confusion on interview suggesting significant dementia
* Alcohol or drug abuse/dependency
* Active psychosis or acute mental disorder
* Participation in other diabetes clinical trials
* Life expectancy \<6 months
Comparison of Phenylephrine and Ephedrine in the Treatment of Hemodynamic Disorders After Spinal Anesthesia in the Elderly

Spinal anesthesia is often used for lower limb surgery in elderly. Hypotension is a side effect of spinal block. In this study, intravenous ephedrine and phenylephrine will be compared with each other to prevent spinal anesthesia-induced hypotension, which is defined in absolute terms as a systolic blood pressure \< 100 mmHg or in relative terms as a 20% fall of systolic blood pressure from baseline.

Randomized single centre clinical randomized study will be performed on 50 participants. The inclusion criteria are participants (age more than 65 years) with proximal femoral fracture scheduled for lower limb surgery under spinal anesthesia.

The Ethics Committee approved this prospective study. Informed consent will be taken from individual subjects. Participants are randomly allocated into one of the two study groups.

Group A: participants who will receive intravenous 25 mg of ephedrine added to syringe with 50 ml 0,9% sodium chloride solution during 20 minutes. Group B: Phenylephrine 5 mg will be added to syringe with 50 ml 0,9% sodium chloride solution, participants will receive intravenous 0,3 mg of phenylephrine during 20 minutes. Randomization is achieved with the help of Random.org.

In order to reduce pain prior to spinal anesthesia an ultrasound-guided fascia iliaca block will be performed using a volume of 30 ml ropivacaine 0,2%. After skin infiltration with 3 ml of lidocaine, a 25G Pencan spinal needle will be inserted at the L3-L4 or L4-L5 vertebral interspaces. After aspirating cerebrospinal fluid, participants will receive hyperbaric bupivacaine 0.5% at 0,11 mg/cm according to the participant height. Ephedrine and phenylephrine will be given intravenous immediately after injection of bupivacaine. Impedance cardiography will be used to measure hemodynamic parameters: cardiac output, stroke volume, cardiac index, stroke index, systemic vascular resistance, systemic vascular resistance index. Heart rate, blood pressure and oxygen saturation will also be controlled. All these parameters will be measured and recorded every 5 minutes until 30 minutes after spinal anesthesia. The data will be statistically analyzed.

Eligibility Criteria:
Inclusion Criteria:

* elderly (age more than 65 years)
* hip fracture scheduled for lower limb surgery under spinal anesthesia
* spinal anesthesia

Exclusion Criteria:

* contraindications to spinal anesthesia
* participant refusal
* age less than 65
* bradycardia (heart rate less than 60)
* participants unable to give consent or inability to communicate
Predictive Factors and Complications of Delirium

The objective of this research was to determine the incidence, predisposing and triggering factors of delirium following cardiac surgery and its consequences within 30 days of surgery and during a 12-18-month follow-up in older adult patients.

Delirium is a transient and fluctuating course syndrome of acute onset that is characterized by reduced level of consciousness, global cognitive dysfunction, and disorder in the sleep-wake cycle. In patients undergoing cardiac surgery, delirium is a complication that affects 2-57% of the patients, reaching as high as 73% in older subjects.

The identification of patients at high risk for delirium is important to deliver proper care and avoid the consequences of this complication. However, previous studies published on the subject have not delivered definitive results in the cardiac surgery setting. Low educational level has also been studied as a risk factor for delirium after surgery but never in a group of cardiac surgery patients that includes a significant rate of illiteracy.

The objective of this research was to determine the incidence, predisposing and triggering factors of delirium following cardiac surgery and its consequences within 30 days of surgery and during a 12-18-month follow-up in older adult patients.

Eligibility Criteria:
Inclusion Criteria:

* Elective cardiovascular surgery

Exclusion Criteria:

* Blindness,
* deafness,
* previous stroke
* dementia
* delirium at inclusion, preoperatively
* creatinine clearance \< 30 ml/min
* emergency surgery
Pilot of Reconnecting to Internal Sensations and Experiences in Undergraduates

Project RISE is a randomized control trial. The intervention consists of four modules that focus on multiple aspects of interoception including: body awareness, body sensations/movement, eating, health and self-care, emotional awareness, and understanding the self in relation to others. The comparator condition is called "Health Habits" and is matched for time and attention; participants complete modules related to healthy habits such as financial planning, hygiene, stretching, and healthy eating. Variables of interest include self-report measures of interoception, eating pathology, suicidality, physiological measures of interoception (electrocardiograph; ECG; pain tolerance measured via algometer), and an implicit association test (IAT) with death and life stimuli (meant to measure implicit associations with suicidality). The population will be college students, with current or past suicidality or low interoception.


Eligibility Criteria:
Inclusion Criteria:

* Low interoceptive awareness
* History of suicidal ideation or attempt
* 18 or older

Exclusion Criteria:

\*Below the age of 18
Improve Outcomes for Older Allogeneic Transplant Recipients

This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.


Eligibility Criteria:
Inclusion Criteria:

Cohort A (Prehab)

1. Age 60 years or older.
2. Planned allogeneic HCT in the next 1-6 months.
3. Hematological malignancy as the indication for HCT.
4. Pre-frail or frail by Fried frailty phenotype.

Cohort B (Rehab)

1. Age 60 years or older.
2. Planned allogeneic HCT or HCT within the last 30 days.
3. Hematological malignancy as the indication for HCT.

Exclusion Criteria:

Cohorts A and B

1. Comorbid disability or illness that prevents safe exercise.
Comparative Effects of BBT and Active Cycle of Breathing Technique on Dyspnea and Quality of Life in COPD

Comparative effects of Butyeko breathing technique and Active Cycle of Breathing technique on dyspnea and quality of life in patients with chronic obstructive pulmonary disease

A comparative study to determine the effects of butyeko breathing techniques and Active Cycle of Breathing technique on dyspnea and quality of life in patients with chronic obstructive pulmonary disease. As few researches on Butyeko breathing techniques are still present on COPD most of them are on asthma. The goal of the Butyeko Method is to improve breathing patterns, as indicated by achieving a higher breath hold time (control pause). Every five seconds improvement to the control pause, results in an alleviation of breathing difficulty and improved control of COPD The Butyeko method is a purported method of "retraining" the body's breathing pattern to correct for the presumed chronic hyperventilation and hypocapnea, and thereby treat or cure the body of these medical problems. Patients with chronic obstructive pulmonary disease (COPD) often suffer from expectoration. To address this problem, active cycle of breathing techniques (ACBT) can be applied in patients of COPD. In our study daily Butyeko breathing exercise and active cycle of breathing technique session of 30 to 35 minutes will be given to patients and effects of both techniques will be compared.

A randomized clinical trial will be conducted using convenient sampling or randomized sampling technique in population of chronic obstructive pulmonary disease (COPD).Total sample size will be of 40 and two Groups will be made Group A 20 participants received Buyteko breathing technique and Groups B 20 participants received Active cycle of breathing technique. Data will be collected by using Borg's dyspnea scale, St.George Respiratory questionnaire and by pulmonary function testing. Data will be collected from pulmonary ward Jinnah hospital Lahore whole study will take total duration of 10 months and data will be analyzed using latest version of SPSS-25 software.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of COPD confirmed by smoking history.
* PFT showing irreversible airflow limitation.
* Patients hemodynamically stable.
* Males and females.
* Patients capable of completing IPAQ questionnaire

Exclusion Criteria:

* Evidence of unstable cardiac disease, Pulmonale decompensation
* Disabling diseases which prevented participation in the exercise program, such as orthopedic inabilities or peripheral vascular disease.
* Systemic illness.
* Resting O2 saturation \<90% with room air breathing and Patient with viral infection
Investigating the Safety and Effect of Overnight Orthokeratology and Its Influencing Factors

To investigate the Safety and Effect of Overnight Orthokeratology and Its Influencing Factors in China

Patients who were successfully prescribed with orthokeratology lenses in Eye Center of the Second Affiliated Hospital of Zhejiang University School of Medicine were enrolled in the study. Our study used two different methods to collect data. For complications and effect of orthokeratology information, data were collected by a retrospective survey. A questionnaire was used to collect influencing factors of safety and effect of orthokeratology.

Eligibility Criteria:
Inclusion Criteria:

* Patients who were successfully prescribed with ortho-k lenses in Eye Center of the Second Affiliated Hospital of Zhejiang University School of Medicine

Exclusion Criteria:

* Patients who have ceased wearing orthokeratology or who were using other methods of myopia control
Clinical Application of Nutrition Support Package Before Hepatectomy

Objective:To confirm the effect of preoperative oral nutrition therapy on patients with malnourished before liver cancer resection.

Study design:Prospective, randomized, controlled clinical study. Primary end point: incidence of all complications 30 days after surgery.


Eligibility Criteria:
Inclusion Criteria:

* 1. Clinical diagnosis of primary liver cancer (including hepatocellular carcinoma, bile duct carcinoma, and mixed cell carcinoma)
* 2. No contraindications for surgery
* 3. Eastern Cooperative Oncology Group (ECOG) score of preoperative physical state \<2 points
* 4. Preoperative liver function score Child-Pugh ≤ 6 points: total bilirubin ≤ 3.0 mg / dl, albumin ≥ 28 g / L, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) ≤ 5 times the upper limit of normal
* 5. Voluntarily enter the study and sign the informed consent form, and communicate well with the researcher

Exclusion Criteria:

* 1. Patients who took fish oil supplements within 3 weeks before the study began
* 2. Patients with severe nutritional risk: serious nutritional risk should be considered when combining any of the following conditions: weight loss \> 10% within 6 months; digital pain score (NRS) score \> 5 points; BMI \<18.5 kg/m2 (all patients with severe nutritional risk undergo individualized supportive care);
* 3. Patients with malignant tumors in other parts
* 4. Patients who are pregnant or lactating
* 5. Patients with mental and neurological disorders who cannot cooperate with medical staff
* 6. Patients with severe diabetes or poor glycemic control
* 7. Patients cannot tolerate nutritional preparations
* 8. Other circumstances that the researcher considers inappropriate to participate in the study
Therapies for Recovery of Hand Function After Stroke

After a stroke, it is very common to lose the ability to open the affected hand. The purpose of this study is to compare the effects of three different therapies on recovery of hand function after stroke and determine if any one is better than the other.

A single-blinded randomized controlled trial will be carried out to assess and compare the effects of 12 weeks of Contralaterally Controlled Functional Electrical Stimulation (CCFES), Cyclic Neuromuscular Electrical Stimulation (cNMES), and Task Oriented Training. Dexterity, upper limb impairment, and activity limitation will be assessed at 0 (baseline), 12 (end of treatment), and 36 weeks. The treatment dose will be the same for all three groups: 10 sessions per week of self-administered treatment at home plus 2 sessions per week of group-specific occupational therapy in the lab.

Eligibility Criteria:
Inclusion Criteria:

* 6 to 24 months since a first clinical cortical or subcortical, hemorrhagic or nonhemorrhagic stroke
* unilateral upper limb hemiparesis with finger extensor strength of grade no more than 4 out of 5 on the Medical Research Council (MRC) scale
* score of at least 1 and no more than 11 out of 14 on the hand section of the upper extremity Fugl-Meyer Assessment
* adequate active movement of the shoulder and elbow to position the hand in the workspace for table-top task practice (necessary for the lab task practice sessions)
* able to follow 3-stage commands
* able to recall at least 2 of a list of 3 items after 30 minutes
* skin intact on the hemiparetic arm
* surface stimulation of the paretic finger and thumb extensors produces functional hand opening without pain (this will exclude those who have too much flexor spasticity)
* able to hear and respond to cues from stimulator
* not receiving occupational therapy (no concomitant OT)
* full voluntary opening/closing of the contralateral (less affected) hand
* demonstrates ability to follow instructions for operating the stimulator or have a caregiver who will assist them

Exclusion Criteria:

* co-existing neurologic diagnosis of peripheral nerve injury, Parkinson's disease, spinal cord injury, traumatic brain injury, or multiple sclerosis
* uncontrolled seizure disorder
* brainstem stroke
* uncompensated hemineglect
* severe shoulder or hand pain
* insensate forearm or hand
* history of potentially fatal cardiac arrhythmias with hemodynamic instability
* implanted electronic systems (e.g. pacemaker)
* botulinum toxin injections to any upper extremity muscle within 3 months of enrolling
* pregnant women due to unknown risks of surface NMES during pregnancy
* lack of functional passive range of motion of the wrist or fingers of affected side
* diagnosis (apart from stroke) that substantially affects paretic arm and hand function
* deficits in communication that interfere with reasonable study participation
* lacking sufficient visual acuity to see the stimulator's display
* concurrent enrollment in another investigational study
Up To Me: Erasing the Stigma of Mental Illness on College Campuses

This is a three-lesson, disclosure-based stigma reduction program meant to reduce barriers to community living and participation for college students with psychiatric disabilities. The goal is to improve community living and participation of individuals with psychiatric disabilities within their postsecondary community using the Honest Open Proud (HOP) program. There are 3 specific objectives of the project:1) evaluate program fidelity, 2) assess program feasibility, and 3) conduct a randomized controlled trial of the HOP program with college students with mental illness to examine its efficacy. Anticipated outcomes include increases in 1) community integration, 2)self-esteem and self-efficacy, 3) empowerment and self-determination, 4) disclosure of mental illness in order to obtain needed support, and 5) care seeking/service engagement for mental illness. Ultimately, we expect to see increased academic persistence and achievement among HOP program completers.


Eligibility Criteria:
Inclusion Criteria:

* College students enrolled at USF
* Over 18 years of age
* Individuals with psychiatric disability(ies) who feel shame regarding their mental illness or keep it secret

Exclusion Criteria:

* Individuals with a sole substance abuse disorder
* Individuals who plan to graduate before the conclusion of the data collection period; for intervention participants, this would be a graduation date within 6 months of starting the intervention.
Helicobacter Pylori Infection in Acute Myocardial Infarction Patients

This study aims to investigate the association between H.Pylori and ACS .

The study is based on show the relationship between H.Pylori infection and Acute Coronary Syndrome .

Active H.Pylori infection is common in ACS and may represent a modifiable risk factor for upper gastrointestinal bleeding.

Eligibility Criteria:
Inclusion Criteria:

* All patients presenting by acute coronary syndrome to Coronary Care Units, Internal Medicine Department, Sohag Faculty of Medicine from 18 .

Exclusion Criteria:

* 1.Patients with Cardiogenic Shock. 2. Renal Impairment.(Creatinine Clearence \<60) 3. A known systemic inflammatory condition. 4.They had taken any antibiotics in the previous 1 months. 5.They had taken any proton pump inhibitors in previous 2 weeks. 6.Gastrointestinal Bleeding.
Multiomics After Cold Pressor Test of People Who Are Unable to Have Headache

Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache.

The aim of the study is to identify factors that protect against headache by studying multiomics in people who never have had a headache (headache resistant) versus non-resistant controls.

The investigators will measure multiomic changes (transcriptomics and metabolomics) after pain induction by Cold Pressor Test. 3 blood samples, two for RNA and one for metabolites are taken 5 minutes before a Cold Pressor Test and again 1 hour after the Cold Pressor Test.

The investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache.


Eligibility Criteria:
Inclusion Criteria:

* Headache resistant and non-resistant male participants from the Danish Blood Donor Study.
* Weight: 45 kg to 95 kg

Exclusion Criteria:

* Daily consumption of any medication.
* Consumption of any medication less than 12 hours prior to the study day.
* Headache on the study day or 48 hours prior to the study day.
* Amnestic or clinical signs of hypertension (systolic blood pressure \>150 mmHg and/or diastolic blood pressure \>100 mmHg) or hypotension (systolic blood pressure \<90 mmHg and/or diastolic blood pressure \<50 mmHg).
* Any severe cardiovascular disease, including cerebrovascular illness.
* Amnestic or clinical signs of current mental illness.
* Amnestic or clinical signs of current substance or drug abuse.
* Amnestic or clinical signs of any illness the responsible doctor considers relevant for participation in the study.
The Effect of Lubricating Gel on Patient Comfort During Speculum Insertion.

The purpose of this study is to determine if lubricating gel affects patients' perception of discomfort during speculum insertion, as compared to water.

The outcome measure is patient discomfort as measured by a visual analogue scale.

Eligibility Criteria:
Inclusion Criteria:

* Women undergoing vaginal speculum examination between the ages of 18 and 50.

Exclusion Criteria:

* Pregnancy.
* Non-English speaking.
* Using hormone therapy.
* Active vulvar or vaginal lesion, infection or complaint.
* Undergoing vaginal or vulvar procedure or biopsy.
* History of chronic pelvic pain, interstitial cystitis or vulvar vestibulitis.
* History of prior vulvar or vaginal surgical procedures.