cyrilzakka/clinical-trials huggingface dataset:
Comparison of Postoperative Analgesic Efficacy of Suprainguinal Fascia Iliaca Block and Pericapsular Nerve Group Block with Lateral Femoral Cutaneous Nerve Block in Patients Undergoing Total Hip Arthroplasty

The goal of this observational study is to compare the analgesic efficacy of SFIB and PENG with LFCN block, and study their effects on opioid consumption, motor strength and ability to perform physiotherapy in the postoperative period in patients who underwent primary total hip arthroplasty under general anesthesia.

48 patients undergoing THA under general anesthesia who received either SFIB or PENG block with LFCN block using will be included in the study. Postoperative static and dynamic VAS scores, opioid consumption, quadriceps motor strength, ability to perform physiotherapy and presence of opioid or nerve block related complications will be recorded.

Eligibility Criteria:
Inclusion Criteria:

* Patients who are scheduled to undergo primary total hip arthroplasty with a diagnosis of coxarthosis

Exclusion Criteria:

* Patients who have a history of neuropathy, patients with renal and hepatic insufficiency, patients with known coagulopathy, patients with a history of allergy to local anesthetics, patients with a history of inguinal surgery on the same side and patients with impaired mental status
Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery

The purpose of this study is to investigate whether robust analgesic regime (protective analgesia) can improve postoperative pain experience for patients undergoing lower wisdom teeth extraction under day case general anaesthetic.

The aim of the study was to demonstrate and improve postoperative pain experience using protective analgesia for patients undergoing oral surgery under day case general anaesthesia.

The primary objective was to investigate the efficiency of protective analgesia using combined effects of sustained release ibuprofen and bupivacaine nerve block in attenuation of postoperative pain following impacted third molar surgery under day case general anaesthesia.

The secondary objective was to document the safety and tolerability profile of conventional release versus sustained released ibuprofen with bupivacaine block in subjects undergoing impacted third molar surgery under day case general anaesthesia.

Eligibility Criteria:
Inclusion Criteria:

* healthy male and female patients aged 18 years and over
* patients requiring removal of one or more third molars, with at lease one completely or partially impacted in the mandible needing bone removal

Exclusion Criteria:

* history of allergy to NSAIDs
* pregnant
* history of GI disease
* history of bleeding disorders
* alcohol dependancy
* drug abuse
Impact of Von Willebrand Factor-platelet Aggregates in Patients With Type 2B Disease

The working hypothesis is that patients with Von Willebrand Disease-type 2B may have neurological symptoms due to the chronic formation of platelets/Von Willebrand Factor aggregates. Interestingly, several patients present nonspecific neurological symptoms (nystagmus, headaches, memory disorder, ...) which may be associated with cerebral microangiopathy and chronic microvessel inflammation secondary to Von Willebrand Disease-type 2B due to chronic exposure to Von Willebrand Factor-platelets complexes.

Investigator will use an extensive series of neuropsychological tests that cover virtually all cognitive domains. A measurement of global cognitive function will be assessed by the Mini Mental State Examination (MMSE). The verbal memory function will be assessed by the Rey Auditory Verbal Learning Test (RAVLT). Visuospatial memory will be administered by the Rey's Complex Figure Test (RCFT). To evaluate speed of mental processes, Stroop test (three subtasks), the Paper and Pencil Memory Scanning Task (four subtasks), the Symbol-Digit Substitution Task will be used. To evaluate attention, the verbal series attention test (VSAT) will be used. To register subjective cognitive failures investigator will administer the Cognitive failures questionnaire (CFQ). The neurological evaluation will be completed with 3T (Tesla) Magnetic Resonance Imaging (MRI) with different MRI sequences including T1 3D SPACE, FLAIR 3D , 3D SWI (Susceptibility weighted imaging) and 2D EPI (Echo Planar Imaging) to address the presence of cerebral small vessel disease. The presence of each of the four MRI markers for cerebral small vessel disease (white matter hyperintensities, lacunes, cerebral microbleeds and perivascular spaces will be addressed.

Eligibility Criteria:
Inclusion Criteria:

* patients with type 2B disease
* neurological signs
* signature of inform consent

Exclusion Criteria:

* contraindication for MRI
* Pregnant women
* other hemorrhagic disease
PRF Versus Advanced PRF in Sinus Augmentation

In the present study the main hypothesis , Advanced PRF will improve the bone quality and quantity in sinus augmentation


Eligibility Criteria:
Inclusion Criteria:

* The Patients with missing posterior maxillary teeth with insufficient available bone for implant placement indicating the need for maxillary sinus floor augmentation before implantation.

  2. The Patients should be free from any systemic disease that may affect normal healing of bone, and predictable outcome.

  3. The Patients should be free from any sinus disease that might affect the health and integrity of the sinus lining.

  4. Assign an informed consent to be involved in the study.

Exclusion Criteria:

Patients with any systemic disease that may affect normal healing. 2. Patients with any sinus disease.

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Deambulatory Epidural During the Labour

Assess the impact of instrumentation and caesarean related to dyskinesia by reducing the concentration of local anesthetic and therefore the motor block.

Prospective, randomized and double-blind study performed on primiparous parturient divided into two distinct groups.

Eligibility Criteria:
Inclusion Criteria:

* Free written consent.
* ASA I or II,
* Primipara, unique and pregnancy over 36 weeks fetus in cephalic, cervical dilation between 3-6 cm
* VAS\> 30 mm
* No contraindications to peridural

Exclusion Criteria:

* Twin pregnancy, less than 36 weeks and 42 weeks
* Fetus in breech position
* Analgesia and sedation within 6h
* Contraindications to peridural
Gastroenteritis in Pediatric Population of Qatar

Comparison of clinical and laboratory diagnosis for cause of Gastroenteritis(GE) depending on the clinical manifestation.Identifying the sources of viral, bacterial and parasitic GE in Pediatric population of Qatar

Processing of stool samples by molecular method (PCR) for children with GE including complete data collection. Patients are followed up for 14 days

Eligibility Criteria:
Inclusion Criteria:

* All acute gastroenteritis patients between 3 months to 14 years presenting to PEC centers with acute diarrhea+/- vomiting with or without fever

Exclusion Criteria:

1. Cases of vomiting +/- fever only without diarrhea
2. Suspicion of surgical abdomen
3. Bile stained vomitus
4. Mal-absorption diseases as cystic fibrosis, celiac disease or increased secretion as disaccharides deficiency
5. Cases of Inflammatory bowel disease
6. Antibiotic associated diarrhea
7. Patients with immune deficiency
8. Patients with chronic diarrhea (\>2 weeks of diarrhea)
9. Patients receiving long term medication for any disease
Single Gene Polymorphisms Associated With Molar-Incisor Hypomineralization

The genetic factors associated with Molar-Incisor Hypomineralization (MIH), a dental condition affecting permanent molars in individuals aged 8-13. Buccal swab samples collected from 90 MIH-affected participants and 90 systemically healthy controls. The goal is to identify potential genetic markers contributing to the etiology of MIH, shedding light on previously unexplored aspects of genetic susceptibility.

The aim of study is to elucidate the unknown aspects of genetic predisposition that may be effective in the etiology of Molar-Incisor Hypomineralization (MIH), that is, to identify unexplored genes that may be associated with MIH. The buccal swab method will be used for the purpose of collecting DNA samples.Samples will be collected from the inner cheek using a swab. The collected samples will be placed in single-use sterile Eppendorf tubes containing Phosphate Buffered Saline (PBS) solution. The samples will be stored at +4 degrees Celsius in a refrigerator, and DNA isolations will be performed within a few days. .

Eligibility Criteria:
Inclusion Criteria:

* Patients aged between 8 and 13 years
* Patients whose parents consent to participate in the study
* Patients who provide cooperation for treatment and study
* For the study group: patients with at least one molar tooth showing molar-incisor hypomineralization
* For the control group: patients without molar-incisor hypomineralization
* Patients without a genetic disease in themselves or their family

Exclusion Criteria:

* Patients with a genetic disease in themselves or their family
3D Maternal Fetal Bonding

To determine whether 3D models of fetus' face created from 3D ultrasound will increase maternal and paternal attachment, lower stress, anxiety and depression and have improved life-style choices during pregnancy. Half of participants will receive 3D model and half will receive a picture of 3D ultrasound of their baby.


Eligibility Criteria:
Inclusion Criteria:

* Age - Female 19-45 years of age; Male \> 19 years of age
* Currently pregnant (\< 32 weeks gestation)
* Have normal 20-week ultrasound

Exclusion Criteria:

* Having received more than 3 ultrasounds prior to study
* Medical need for additional ultrasounds
* Multiple fetuses
* \> 31 weeks gestation
Improving ToM in Children With ASD Through VPT Training: Behavioral and fNIRS Study

This study aims to employ a longitudinal tracking research to investigate the effects of a visual perspective taking intervention on the development of theory of mind in children with autism. Additionally, the investigators seek to examine modifications in the neural mechanisms linked to facial emotion recognition in children both before and after intervention by using the functional Near-Infrared Spectroscopy (fNIRS) to record the relative changes in blood oxygen levels in the cerebral cortex with the oddball Face-Periodic Visual Stimulation (FPVS) paradigm.

The deficiency or delayed development of Theory of Mind (ToM) stands as a significant contributing factor to social disorders observed in children with Autism Spectrum Disorder (ASD). Consequently, improving ToM ability is considered pivotal way to improve the development of social function of children with ASD. This study aims to improve ToM ability of children with ASD, and the purpose of this study are as follows:

1. Reveal the development mechanism of theory of mind of children with ASD, based on embodied cognition theory. Explore whether visual perspective taking training can improve the development of Theory of Mind in children with ASD, and if such enhancement exhibits long-term stability.
2. Undertake a longitudinal investigation to assess the stability of visual perspective taking training in improving the development of Theory of Mind in children with ASD. Additionally, the study aims to compare the differential effects and stability of various intervention programs in improving the Theory of Mind in children with ASD.
3. Explore potential disparities in the brain mechanisms of facial emotion recognition between children with ASD and typically developing children before and after the intervention. Specifically, the study seeks to discern whether the intervention can enhance facial emotion recognition abilities in children with ASD and assess the longevity of such enhancements.

The study consists of two parts. In Study 1, participants will be randomly assigned to distinct training groups based on baseline task performance, undergoing three sessions per week for a duration of 4 weeks. In Study 2, the investigators will mainly use the fNIRS with the oddball FPVS paradigm to test children's ability to distinguish facial emotion pictures before and after the intervention, assessing whether the intervention enhances facial emotion recognition ability and if effects vary across different training methods.

Eligibility Criteria:
Inclusion Criteria:

ASD group:

* With a diagnosis of ASD.
* Age between 3 and 8 years old.
* Monolinguals, Chinese native speakers.
* Providing written informed consent sighed by parents.

Control group:

* No diagnosis of ASD (including individuals who are typically developing, have attention deficit hyperactivity disorder, etc.)
* Age between 3 and 8 years old.
* Monolinguals, Chinese native speakers.
* Providing written informed consent sighed by parents.

Exclusion Criteria:

* Language or motor impairments hindering participation in the study.
Comparison of the Distance Between the Femoral Artery and Veins in Various Position in Malay Race Adult

The purpose of this study is to compare the distance between femoral artery and vein in frog position, abduction-exorotation position and anatomical position.

The incidence of unintentional arterial puncture during cannulation of femoral vein was high(20-50%). The addition of knee flexion to abcudtion-exorotation position (frog position) have been shown to increase the cross sectional area of femoral vein. The purpose of this study is to compare the distance between femoral artery and vein in frog position, abduction-exorotation position and anatomical position.

This study is an analytical observational study with cross sectional design within one grup with repeated measurement. The distance between artery and vein was measured in three position. The measurement was taken twice for each position. First picture was taken by one operator and one ultrasonography for all patient. Then another operator measured the distances with caliper feature on the ultrasonograph.

Eligibility Criteria:
Inclusion Criteria:

1. Malay race adult 18-60 years old
2. Agree to participate in the study and undergoing femoral vein cannulation
3. Normal weight with IMT 19-25 kg/m2

Exclusion Criteria:

1. Previous cannulation on the same vein
2. Femoral vein catheter has been placed
3. Anatomical variation (artery-venous malformation, venous or artery branch at 2 cm inferior to inguinal ligament)
4. Abdominal distention
5. Femoral vein thrombosis
6. Hypotension (Mean Arterial Pressure \<65 mmHg, or using vasopressor or inotrope)

Drop out Criteria:

1. Anatomical abnormalities of femoral vein or artery visualized using ultrasonography examination
2. Fail to visualize femoral vein or artery using ultrasonography for two minutes, operated by trained personnel and declared competent by cardiovascular anesthesiologist consultant
3. Patient not cooperative during procedure, hence, unable to maintain limb position for more than 2 minutes in any position examined
4. Patients with right femur fracture
Anticoagulation Regiments in Patients With Prosthetic Heart Valve Thrombosis

Prosthetic valve thrombosis is a serious complication with high mortality and morbidity. However, the best anticoagulant treatment strategies for patients with prosthetic heart valve thrombosis have not been fully known. In this study the investigators wanted to identify the most effective and safe regimen among different anticoagulant regimens.

Three different anticoagulant treatment regimens for patients with prosthetic heart valve non-obstructive thrombosis have been described. Patients are included in each group randomly. In the first arm only warfarin is given to the patients with a target INR level of 2.5-4. In the second arm 100 mg acetylsalicylic acid and a proton pump inhibitor are added to treatment in combination with warfarin. In the third arm 300 mg acetylsalicylic acid and a proton pump inhibitor are added to treatment in ombination with warfarin. Also there is an observational follow-up group of patients who do not have prosthetic heart valve thrombosis. These patients also are followed under only warfarin therapy with INR level of 2.5-4 . All patients are followed by serial transesophageal echocardiography performed every 6 months. Follow-up period is at least 6 months (range 6-60 months). Informed consent is taken from all patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients with prosthetic heart valve thrombosis

Exclusion Criteria:
Brief Delay in Cord Clamping and Neurobehaviour in Preterms

RESEARCH HYPOTHESIS Brief delay(\>30 sec to \<60 sec ) in cord clamping as compared to early cord clamping (\< 20 sec) leads to a better short term neurobehavioural outcome in preterm (34-36 wks) neonates when assessed by neurobehavioral assessment of preterm infants (n.a.p.i.) at 37 weeks of post conceptional age

Delayed cord clamping (DCC) : Well described phenomenon in term infants .

* The optimal timing of clamping of umbilical cord in preterm infants : A subject of debate.
* Even a brief delay in cord clamping leads to an additional transfer of iron amounting to 40-50 mg/kg which may prevent iron deficiency.¹
* This low cost intervention can have significant public health importance in resource constrained settings.
* The effect of this intervention on neurobehaviour of preterm neonates has not been assessed.
* This aspect has been identified by WHO and Cochrane as a potentially researchable area

Eligibility Criteria:
Inclusion Criteria:

* All preterm deliveries -infants born at 34 weeks 0 days to 36 weeks +6 days gestational age as estimated by last menstrual period or early ultrasound scan.
* Infants delivered vaginally or by caesarean section in cephalic presentation
* Singleton pregnancy
* Parental consent

Exclusion Criteria:

* Fetus with gross congenital anomaly
* Fetus with hydrops
* Rh negative pregnancy
Nutritional Status Among Older Adults. Risk Factors and Consequences of Malnutrition

The aim of the study is to estimate the prevalence of malnutrition among older adults admitted to hospital and to analyse predictive factors for malnutrition. Further, the aim was to analyse the association between nutritional status and all-cause and cause-specific mortality.

The hypothesis is that malnourished patients have a higher mortality then well-nourished patients after three years.

The baseline survey was a cross-sectional study of 1771 patients aged ≥65 years who were admitted to hospital. Nutritional status was assessed using the MNA instrument, and possible risk factors associated with malnutrition were recorded during the hospital stay. All-cause mortality was followed up after median 3.5 years s in a cohort study of 1767 participants. Cause-specific mortality was followed up after median 4.7 years in a cohort of 1767 participants. Previous dietary intake in middle-aged and older adults was recorded at basline in 725 participants, who had their nutritional status assessed with the MNA when admitted to hospital 10 years later.

Eligibility Criteria:
Inclusion Criteria:

* Patients 65 years or older

Exclusion Criteria:

* unable to communicate and no relative could anwer the questions (n = 356)
* receiving palliative care (n = 44)
* impossible to measure height or weight (n = 22)
* miscellanious (n = 71)
Effect of Exercise on Blood Coagulation in Persons With Chronic Spinal Cord Injury

The purpose of this study is to determine if exercise affects the clotting of blood (hemostasis). The effect of exercise on hemostasis will be determined in persons with spinal cord injury, a population reported to have an increased prevalence of cardiovascular disease (CVD). It is expected that this study will increase our understanding of CVD in persons with SCI, and it will eventually help reduce the occurrence of premature heart disease.

Regular moderate intensity physical exercise decreases platelet aggregability as a consequence of increasing levels of tissue plasminogen activator (tPA) and reducing levels of plasminogen activator inhibitor-1 (PAI-1). In addition, the exercise-associated improvement in the lipid profile and reduction in fat mass may decrease platelet aggregability and blood coagulation, as well as increase fibrinolysis. Thus, it can be hypothesized that physical exercise training has a powerful beneficial impact on blood coagulation and fibrinolysis. Although, regular exercise has been shown to reduce the incidence of CVD and death or causes a regression of symptoms in able-bodied individuals, this salutary effect of prolonged (months) exercise in persons with SCI has not been documented. The present study will evaluate the effects on hemostasis of exercise training in persons with chronic SCI. The effect of exercise on hemostasis will be determined in persons with SCI, a population appreciated to have an increased prevalence of cardiovascular disease (CVD). It is anticipated that this study will ultimately increase our understanding of CVD in this group, and it will eventually help reduce the occurrence of premature macrovascular disease.

Eligibility Criteria:
Inclusion Criteria:

SCI subjects (n=12) with stable chronic, complete paraplegia, (T1 to T10) and quadriplegia (C4 to C8) (for more than 1 year) will be recruited. The paraplegia subjects should be able to transfer independently in/out of a wheelchair.

Exclusion Criteria:

1. Ambulatory persons with SCI
2. Less than 18 years or greater than 65 years old
3. Chronic illness (dialysis)
4. Evidence or history of heart and/or vessel disease (arrhythmias, ischemia at rest)
5. Platelet or coagulation disorders
6. Prescribed use of on aspirin or non-steroidal anti inflammatory drugs
7. Active illness (sepsis, pressure sores)
8. Uncontrolled spasticity
9. Contractures (fixed) in upper extremity/lower extremity Heterotopic ossification at hips, knees, that limit range of motion while seated for FES
Urotherapy vs. Urotherapy With Constipation Treatment for Children With Lower Urinary Tract Dysfunction

Constipation treatment has been found to ameliorate symptoms in some patients with lower urinary tract dysfunction (including day time or combined day time/night time urinary incontinence). This study aims to explore if treatment of patients without overt constipation (As defined by the ROME III criteria) will also respond to anti-constipation treatment with reduction of their urinary tract symptoms. Assessment of severity and response of lower urinary tract dysfunction will be based on the Vancouver NULTD/DES questionnaire.


Eligibility Criteria:
Inclusion Criteria:

1. Aged 5-17 years at time of signing of informed consent.
2. Lower urinary tract dysfunction (LUTD)-daytime/daytime and nighttime urinary incontinence as defined by a score of \>11 on the Vancouver Questionnaire .
3. Do not meet Rome III criteria for functional constipation.

Exclusion Criteria:

1. Inability to provide signed informed consent.
2. Inability to comply with the study protocol.
3. Neurogenic bladder
4. Attention Deficit Disorder (ADD or ADHD) on medical treatment.
5. Known significant sacral, perineal, or other congenital or surgical defect.
6. Known orthopedic/neurological disease which may affect urinary continence, cause constipation, or affect reading of abdominal x-rays. (e.g. spastic cerebral palsy, severe scoliosis)
7. Patient taking medicinal drugs which can cause urinary incontinence or constipation.