cssi/SciSciGPT-SciSciNet huggingface dataset:
Personality and Medical Specialty Choice: A Literature Review and Integration

This review examines the literature on personality and medical specialty choice. First, it describes studies categorized by medical specialties that to date have used the same measures: Adjective Check List, California Psychological Inventory, Sixteen Personality Factor Questionnaire, and Myers-Briggs Type Indicator. Then it integrates these results using the framework provided by the Five-Factor Model of personality. This model provides a method to organize the personality descriptors associated with medical specialties and to summarize information in an understandable and meaningful way. Conclusions drawn from the review suggest a loose association between a few personality factors and particular medical specialties. Recommendations for further research on personality and medical specialties encourage shifting from the “variable” to the “person” approach and studying how different personalities succeed in the same specialty.
General model for estimating bubble dissolution and droplet evaporation times

Bubbles and droplets may be detrimental to the successful implementation of immersion lithography, depending in part on their lifetime in the system. In this work, a model is developed to estimate the dissolution times of nitrogen bubbles in pure water that may be free-floating or adhered to a solid surface. The model is then extended to small free and adhered droplets. Bubble dissolution and droplet evaporation times for typical immersion lithography conditions are presented.
Mexican Immigrant Families Under Siege: The Impact of Anti-Immigrant Policies, Discrimination, and the Economic Crisis

Latino immigrants have historically faced many challenges living in the United States (U.S.). The economic crisis combined with new anti-immigration policies and harsh enforcement strategies may exacerbate the stress and anxiety Latino immigrant families already endure as a result of discrimination and financial hardships. The purpose of this study was to understand the current challenges Latino immigrant families encounter within an anti-immigrant social-political environment. Fifty-two first generation immigrants participated in focus group sessions, which lasted between 90 and 120 minutes. The findings reveal that the economic crisis, anti-immigration policies, and enforcement strategies have deleterious effects on Latino immigrant families’ well-being. Participants stated that their limited English proficiency status and racial profiling were the basis for discriminatory practices they endured. Discrimination is experienced through instances of micro-aggression, as well as horizontal discrimination and institutional discrimination. Implications for social policy, social work practice, and research are discussed.
Implementation and evaluation of an analytical solution to the photon attenuation and nonstationary resolution reconstruction problem in SPECT

The implementation and evaluation of an analytical solution to the photon attenuation and nonstationary resolution reconstruction problem in single photon emission computed tomography (SPECT) are presented. The method is based on a combination of the Bellini attenuation compensation and the Appledorn nonstationary resolution correction algorithms. It is termed the simultaneous correction algorithm (SCA). The results of testing the method with point source acquisitions showed a significant improvement in reducing the nonstationary behavior of the collimator response. The ratios of the FWHMs showed better agreement with the ideal value of 1.0, and the modulation transfer functions (MTFs) of the point spread functions exhibited less positional variation when using the SCA over other methods. In addition, the initial quantitative values were restored to acceptable levels. >
Abstract P4-05-06: Elevated frequency of a deleterious deep intronic BRCA2 splice variant in non-Caucasian Americans

Introduction: In 2012, Anczukow et al (Clin Cancer Res 2012;18:4903-9) described a deep intronic BRCA2 variant between exons 12 and 13 that was discovered because a cell line from a patient with hereditary breast and ovarian cancer (HBOC) produced an aberrant mRNA. The variant (c.6937 +594 T>G; rs191253965), which further improved splice site sequence to consensus, was also identified in 8 additional families. Segregation analysis of 13 affected relatives from 6 families revealed that all affected family members had the c.6937 + 594 T>G variant, providing strong evidence that it is deleterious. All resided in France, but ethnicity was not specified. This variant was also seen in 5 individuals in the 1000 genomes project. Since this is a deep intronic variant, standard BRCA2 sequencing tests that determine only a limited number of bases into each intron would not detect it. For these reasons, we included a bait tile for the intron harboring this variant in the design of our hybrid capture-based next generation sequencing (NGS) test for comprehensive BRCA1 and BRCA2 analysis. Here we investigate the frequency of this variant in samples submitted for comprehensive BRCA1 and BRCA2 testing, and assessed carrier frequency in samples submitted for non-BRCA–related genetic testing. Methods: We reviewed the de-identified results of the first 2300 clinical samples submitted to our reference laboratory for comprehensive BRCA1 and BRCA2 testing to assess the frequency of the c.6937 + 594 T>G variant. Results: This deep intronic variant was observed in 12 of the initial 2300 patient samples. All 12 individuals were affected with HBOC and were Hispanic. To estimate the population frequencies of this variant in various ethnic groups, we anonymized samples submitted for Cystic Fibrosis Carrier Detection and subjected them to a single-site assay for this variant. In all, 344 patients self-identified as Caucasian, 355 as Hispanic, 140 as African American, and 73 as Asian. The frequency of c.6937 +594 T>G heterozygotes was 0.30% (1 individual) in Caucasians, 1.1% (4) in Hispanics, 0.8% (1) in African Americans, and 1.4% (1) in Asians. Conclusions: In an initial series of comprehensive BRCA analyses, we discovered that a deep intronic variant known to cause aberrant splicing and to segregate with HBOC is present at elevated frequencies in non-Caucasian Americans. We have already observed this variant in 12 Hispanic HBOC patients. Physicians could consider testing for this variant in women of non-Caucasian ancestry with HBOC who have had negative results on BRCA assays that do not test for c.6937 +594 T>G. Citation Format: Charles M Strom, S Rivera, M Peng, Wendy Conlon, B Crossley, W Sun. Elevated frequency of a deleterious deep intronic BRCA2 splice variant in non-Caucasian Americans [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-05-06.
Effect of estradiol-17beta administration during the time of conceptus elongation on placental size at term in Meishan pigs.

Meishan embryos transferred to recipient females on d 2.5 are larger, contain greater numbers of trophectoderm cells, and secrete greater amounts of estradiol-17beta (E2beta) when gestated in a Yorkshire as compared with Meishan uterus to d 12. Additionally, placentas of Meishan conceptuses are larger when gestated in a Yorkshire as compared with Meishan uterus throughout gestation. Embryonic E2beta secretion during elongation on d 12 to 13 of gestation is temporally associated with endometrial secretion of growth factors, including IGF-I, which has been shown to increase mitotic rate in the trophectoderm of pig embryos. This experiment was conducted to determine whether E2beta administration to Meishan gilts at the time of conceptus elongation would increase placental size at term. Meishan gilts (n = 12) were checked twice daily for estrus (0700 and 1900), and each was bred to a Meishan boar at 0 and 24 h after the onset of estrus (d 0). Gilts were randomly assigned in equal numbers to receive injections of sesame oil (VEH) starting on d 12 (control), 1 mg of E2beta in VEH starting on d 12 (E212), or 1 mg of E2beta in VEH starting d 13 (E(2)13). The injections were initiated at 0700 or 1900 (corresponding to the time of day they first exhibited estrus) and continued at 6-h intervals for 48 h, resulting in 8 mg of E2beta given in eight injections. Pregnant gilts were killed on d 112 of gestation, and ovulation rate, litter size, implantation site length, fetal weight, crown-rump length, placental weight, and placental surface area were quantified. There were no differences among E(2)12, E(2)13, and control females in ovulation rate or litter size, which averaged 16.3 +/- .7 and 11.8 +/- .7, respectively. Fetal weight and crown-rump length were not different (P > .10) among E(2)12, E(2)13, and control females, averaging 802 +/- 26 g and 24.3 +/- .3 cm. Placentas were markedly heavier (176 +/- 14 and 174 +/- 16 vs 134 +/- 10 g, P < .05) and larger (1,337 +/- 97 and 1,520 +/- 70 vs 978 +/- 29 cm2, P < .001) for E(2)12 and E(2)13 vs control gilts, respectively. Placental efficiency (estimated as fetal weight:placental weight) was greater (P < .05) in the control than in the E(2)12 and E(2)13 gilts (5.8 +/- .2 vs 4.8 +/- .2 and 5.1 +/- .4). These data demonstrate that the amount of E2beta exposure around the time of elongation affects placental size at term. Additionally, the difference in placental efficiency between control and E2beta groups indicate that E2beta-induced increases in placental size led to a reduced placental efficiency.
Hypothetical roles of angiogenesis, osmotic swelling, and ischemia in high-altitude cerebral edema.

High-altitude cerebral edema (HACE) has been tentatively attributed to either cellular ion pump failure from ATP depletion or high cerebral blood flow inducing high capillary pressure. These hypoth...
Invertible Dynamics on Blow-ups of {\mathbb {P}}^{k}

This is a survey of some recent results on the iteration of (pseudo) automorphisms of blowups of k-dimensional projective space.
Do high‐impact invaders have the strongest negative effects on abundant and functionally similar resident species?

Summary Although invasive plants may out-compete and cause local-scale extirpations of resident species, it is widely observed that they cause few extinctions at larger spatial scales. One possible explanation is that highly successful invaders tend to be functionally similar to, and therefore compete most strongly with, resident species that are also relatively successful and widespread. High abundance may then protect these functionally similar residents from complete extinction over large areas despite their stronger competition with the invader. We tested this idea in a native-rich grassland where a novel invader, Aegilops triuncialis (barb goatgrass), strongly affects community diversity at the local scale. We compared resident species abundances in paired invaded and uninvaded plots with similar soil and community characteristics and invasibility as assayed by experimentally planted Aegilops. We found that the negative effects of the invader on abundance were strongest on resident species belonging to the same functional group as the invader (annual grasses). Within grasses, multivariate functional similarity to the invader also predicted decline in abundance under invasion. However, we did not find the predicted general relationship between abundance, functional similarity to the invader, and tendency to decline under invasion. Additional factors, such as spatial heterogeneity in the invaded community, must contribute to the relative scarcity of large-scale extinctions under invasion.
Mechanotransduction in Caenorhabditis elegans: the role of DEG/ENaC ion channels.

One of the looming mysteries in signal transduction today is the question of how mechanical signals, such as pressure or mechanical force delivered to a cell, are interpreted to direct biological responses. All living organisms, and probably all cells, have the ability to sense and respond to mechanical stimuli. At the single-cell level, mechanical signaling underlies cell-volume control and specialized responses such as the prevention of poly-spermy in fertilization. At the level of the whole organism, mechanotransduction underlies processes as diverse as stretch-activated reflexes in vascular epithelium and smooth muscle; gravitaxis and turgor control in plants; tissue development and morphogenesis; and the senses of touch, hearing, and balance. Intense genetic, molecular, and elecrophysiological studies in organisms ranging from nematodes to mammals have highlighted members of the recently discovered DEG/ENaC family of ion channels as strong candidates for the elusive metazoan mechanotransducer. Here, we discuss the evidence that links DEG/ENaC ion channels to mechanotransduction and review the function of Caenorhabiditis elegans members of this family called degenerins and their role in mediating mechanosensitive behaviors in the worm.
Management of hyperhidrosis.

The topical medications used to control excessive perspiration either absorb excess sweat or block sweat ducts. Methenamine promises to be quite effective for this purpose. Systemic medications, such as tranquilizers or mild sedatives, are often effective when the emotional component is prominent. Usefulness of the anticholinergic drugs is limited by systemic side effects.
The vertical distribution and reproductive biology of Pelogobia longicirrata (Annelida) in the central Arctic ocean.

During a two year period the vertical distribution of Pelogobia longicirrata (Polychaeta, Annelida) in the central Arctic ocean changed seasonally in conjunction with the relative age of the organisms. Adults with thirteen or more segments were primarily found throughout the year from 100-500m. The peak occurrence of oocytes in the two month period of May/June was followed by a rapid decline in July/August, suggesting a spawning season in early summer or late spring. Larvae subsequently appeared below 500 m where specimens with one to three segments accounted for most of the animals collected between 900 m and 1200 m. Specimens with six or more segments were the youngest observed to have a mouth, anus, a continuous digestive tract, and a muscled pharynx, indicating that larvae smaller than these are probably incapable of feeding. They may instead live off of stored yolk retained from the egg. It is suggested that as the larvae mature they move up the water column and eventually join the adult population. ...
Transportation and logistics cluster competitive advantages in the U.S. regions: A cross-sectional and spatio-temporal analysis

Abstract This article applies spatial cluster and econometric analyses to study attributes of the transportation and logistics cluster regions across the continental U.S., focusing on jobs, clustering, and dispersal patterns. Two questions are examined: 1) Is transport and logistics specialization a primary feature of large urban metropolitan regions or do rural nonmetropolitan regions (be they micropolitan or noncore) have the capacity to support this type of cluster? 2) Does transport infrastructure explain jobs in the transportation and logistics cluster? The research employs a county level lattice data of transportation and logistics cluster jobs from 2008 to 2012 as well as transport infrastructure variables. The findings reveal that the transportation and logistics clusters are concentrated primarily in metropolitan areas, and to some degree, in nonmetropolitan regions of the U.S. In addition, the transport infrastructure is found to have a positive impact on jobs in the transportation and logistics clusters over the period of the study. Intermodals have the largest effect on jobs, followed by airports, annual average daily traffic on the National Highway Planning Network, railroads, and ports.
TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation

Clathrin-mediated endocytosis (CME) constitutes the major pathway for uptake of signaling receptors into eukaryotic cells. As such, CME regulates signaling from cell-surface receptors, but whether and how specific signaling receptors reciprocally regulate the CME machinery remains an open question. Although best studied for its role in membrane fission, the GTPase dynamin also regulates early stages of CME. We recently reported that dynamin-1 (Dyn1), previously assumed to be neuron-specific, can be selectively activated in cancer cells to alter endocytic trafficking. Here we report that dynamin isoforms differentially regulate the endocytosis and apoptotic signaling downstream of TNF-related apoptosis-inducing ligand-death receptor (TRAIL-DR) complexes in several cancer cells. Whereas the CME of constitutively internalized transferrin receptors is mainly dependent on the ubiquitously expressed Dyn2, TRAIL-induced DR endocytosis is selectively regulated by activation of Dyn1. We show that TRAIL stimulation activates ryanodine receptor-mediated calcium release from endoplasmic reticulum stores, leading to calcineurin-mediated dephosphorylation and activation of Dyn1, TRAIL-DR endocytosis, and increased resistance to TRAIL-induced apoptosis. TRAIL-DR-mediated ryanodine receptor activation and endocytosis is dependent on early caspase-8 activation. These findings delineate specific mechanisms for the reciprocal crosstalk between signaling and the regulation of CME, leading to autoregulation of endocytosis and signaling downstream of surface receptors.
L2 Reading: Strategies and Gender Preferences in the Foreign Language Classroom

L2 reading comprehension and the development of strategies that further students’ foreign language development are critical for learners and teachers. Drawing from current research on reading strategies and gender, this article discusses existing and emerging trends on the use of specific reading strategies as they pertain to gender preferences, and proposes pedagogical recommendations that address the needs of each gender while keeping the classroom balanced and free of gender biases.
Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

Human coronaviruses (HCoVs) enter cells via two distinct pathways: the endosomal pathway using cathepsins to activate spike protein and the cell-surface or early endosome pathway using extracellular proteases such as transmembrane protease serine 2 (TMPRSS2). We previously reported that clinical isolates of HCoV-229E preferred cell-surface TMPRSS2 to endosomal cathepsin for cell entry, and that they acquired the ability to use cathepsin L by repeated passage in cultured cells and were then able to enter cells via the endosomal pathway. Here, we show that clinical isolates of HCoV-OC43 and -HKU1 preferred the cell-surface TMRRSS2 to endosomal cathepsins for cell entry, similar to HCoV-229E. In addition, the cell-culture-adapted HCoV-OC43 lost the ability to infect and replicate in air-liquid interface cultures of human bronchial tracheal epithelial cells. These results suggest that circulating HCoVs in the field generally use cell-surface TMPRSS2 for cell entry, not endosomal cathepsins, in human airway epithelial cells.
Informing Medicare's Two-Midnight Rule Policy With an Analysis of Hospital-Based Long Observation Stays.

Study objective Outpatient observation stays are increasingly substituting for standard inpatient hospitalizations. In 2013, the Centers for Medicare & Medicaid Services adopted the controversial Two-Midnight Rule policy to curb long observation stays and better define the use of hospital-based observation services versus inpatient hospitalizations. We seek to determine the extent to which Medicare beneficiaries exposed to long observation stays (>48 hours) are clinically similar to those with short observation stays (≤48 hours) because this has relevance to the Two-Midnight Rule. Methods Using 100% Medicare claims data from 2008 to 2010, we identified all patients with long observation stays (>48 hours) who were admitted through the emergency department (ED). We report beneficiary characteristics, as well as crude and risk-adjusted 30-day rates of mortality, readmissions, and return ED visits stratified by observation stay length. Results Seven percent of 2.8 million observation stays were greater than 48 hours. Beneficiaries with long observation stays tended to be older, women, nonwhite, and urban residents, with a greater number of comorbid conditions. Crude rates increased with observation stay length for all 3 outcomes. However, after directly standardizing the rates, we observed the reverse trend because all adjusted rates decreased stepwise with observation stay length greater than 48 hours in a dose-response pattern. Conclusion Patients with observation stays lasting longer than 48 hours are a clinically distinct population. Our findings support the conceptual underpinnings of the Two-Midnight Rule, but suggest that observation versus inpatient determinations should be based on actual length of stay rather than prospective prediction to reduce the administrative ambiguity this policy has created.
Internal shocks in microquasar jets with a continuous Lorentz factor modulation

We perform relativistic hydrodynamic simulations of internal shocks formed in microquasar jets by continuous variation of the bulk Lorentz factor, in order to investigate the internal shock model. We consider one-, two-, and flicker noise 20-mode variability. We observe emergence of a forward-reverse shock structure for each peak of the Lorentz factor modulation. The high pressure in the shocked layer launches powerful outflows perpendicular to the jet beam into the ambient medium. These outflows dominate the details of the jet's kinetic energy thermalization. They are responsible for mixing between the jet and surrounding medium and generate powerful shocks in the latter. These results do not concur with the popular picture of well-defined internal shells depositing energy as they collide within the confines of the jet, in fact collisions between internal shells themselves are quite rare in our continuous formulation of the problem. For each of our simulations, we calculate the internal energy deposited in the system, the "efficiency" of this deposition (defined as the ratio of internal to total flow energy), and the maximum temperature reached in order to make connections to emission mechanisms. We probe the dependence of these diagnostics on the Lorentz factor variation amplitudes, modulation frequencies, as well as the initial density ratio between the jet and the ambient medium.
Language development in the pediatric cochlear implant patient

Objective To access the long-term outcomes of children implanted during most sensitive period for language development. Study design Literature review. Method An initial PubMed search was carried out using the search terms language development and cochlear implant resulted in 1149 citations. A second search was carried out on the initial citations using the criterion of implantation in the period of birth to 24 months, which identified 386 articles. These were analyzed to determine those studies in which linguistic outcome was measured at least three or more years following implantation. Results Twenty-one reports published from 2004 to 2017 that met the criteria. The range of follow-up was from 3 years to an excess of 10 years. Four => 10-year follow-up reports were consistent in showing that the earlier the subject is implanted the better the outcome. Many, but not all, of these children did obtain age-appropriate language. There were 17 reports with follow-up from 3 to less than 10 years. In 7 of the 11 studies, the children's expressive language was reported to have reached an age level of less than 80%. The results for receptive language showed that 4 of the 11 studies found that the children achieved a receptive language age level of less than 80%. There were 8 studies which documented the effect of implantation before 12 months of age and between 12 and 24 months of age and they all found that the earlier the implantation, the better the outcome for language. Conclusion The cochlear implant is efficacious in the amelioration of receptive and expressive language deficits in most congenitally deafened children implanted before the age of one. The language outcomes for those implanted after the age of one decline as the age of implantation increases. Level of evidence N/A.
Hybrid Differentially-Private String Matching

Private record linkage enables multiple parties to exchange records of similar entities without disclosing their own data sets. Several techniques solve private matching for numerical attributes, but they cannot handle well string-typed data. We propose a protocol for differentially-private linkage of records with string-valued attributes. String-valued data are partitioned into groups, and each partition is represented by a synopsis. Strings are first embedded into a metric space which preserves the relative distance among them, and then they are translated to multi-dimensional points. We propose two partitioning algorithms: the first one uses solely Lipschitz embedding coordinates, whereas the second one also leverages string length information. To the best of our knowledge, this is the first efficient and provably secure solution to the private string matching problem. Extensive experimental results on a real dataset demonstrate that our solution is efficient and accurate. We also show that our solution can be adapted to alternative protection models, e.g., output-constrained differential privacy.
On Linear Refinement of Differential Privacy-Preserving Query Answering

Recent work showed the necessity of incorporating a user’s background knowledge to improve the accuracy of estimates from noisy responses of histogram queries. Various types of constraints (e.g., linear constraints, ordering constraints, and range constraints) may hold on the true (non-randomized) answers of histogram queries. So the idea was to apply the constraints over the noisy responses and find a new set of answers (called refinements) that are closest to the noisy responses and also satisfy known constraints. As a result, the refinements expect to boost the accuracy of final histogram query results. However, there is one key question: is the ratio of the distributions of the results after refinements from any two neighbor databases still bounded? In this paper, we introduce a new definition, ρ-differential privacy on refinement, to quantify the change of distributions of refinements. We focus on one representative refinement, the linear refinement with linear constraints and study the relationship between the classic e-differential privacy ( on responses) and our ρ-differential privacy on refinement. We demonstrate the conditions when the ρ-differential privacy on refinement achieves the same e-differential privacy. We argue privacy breaches could incur when the conditions do not meet.
Surface Modifications in Transparent Dielectrics Induced by a Mid-Infrared Free-Electron Laser

Irradiation of wide-bandgap dielectrics using tunable picosecond infrared pulses at high repetition rate is shown to induce unusually efficient ablation, phase transformations and the evolution of a Kelvin-Helmholtz hydrodynamic instability.
The Voice of the State

This is a really good book. Brettschneider’s When the State Speaks is both provocative and persuasive, resolving a stubborn conflict within democratic theory in a way many will initially reject, but which he argues for so effectively that, by the end, the controversial appears the commonsensical. The problem Brettschneider addresses is one with which we are all familiar. In democracies we believe in the right to free speech. We believe that this right is implied by the underlying principles of democracy, and believe that the exercise of this right is essential for democracy to function. We are presented with a conflict when some people use their right to free speech to advocate values that are contradictory to democracy: to argue that not everyone should be allowed to speak, to argue that not all citizens are equal, to argue that some people should be discriminated against for reasons of race, religion, sex, or other distinctions that, in a democracy, we hold to be irrelevant. The problem is that if we follow democratic principles and protect such speech effectively, it may lead to the curtailment of free speech and the loss of equality: protecting the democratic rights of those who oppose democracy can result in the weakening of democracy through general disrespect of democratic rights. There are two familiar, opposing strategies for dealing with this dilemma. One is to say that the right to free speech does not include speech that promotes antidemocratic values. Hate groups, for example, insofar as they proclaim that some people should receive unequal treatment in the public realm, should not be protected in the expression of their anti-democratic views. Theorists who hold this relatively intolerant position may argue that it should be illegal to express certain discriminatory opinions, and may approve of interfering with the expression of such unwelcome views even when that occurs in the private sphere. The contrasting position is that a democratic state should remain neutral about the content of speech:
Genome Regulation by Long Noncoding RNAs

The discovery of extensive transcription of long noncoding RNAs (lncRNAs) provide an important new perspective on the centrality of RNA in gene regulation. I will discuss genome-scale strategies to...
Optimization of Second Window Indocyanine Green for Intraoperative Near-Infrared Imaging of Thoracic Malignancy

Background Near-infrared (NIR) imaging using the second time window of indocyanine green (ICG) allows localization of pulmonary, pleural, and mediastinal malignancies during surgery. Based on empirical evidence, we hypothesized that different histologic tumor types fluoresce optimally at different ICG doses. Study Design Patients with thoracic tumors biopsy-proven or suspicious for malignancy were enrolled in an NIR imaging clinical trial. Patients received a range of ICG doses 1 day before surgery: 1 mg/kg (n = 8), 2 mg/kg (n = 8), 3 mg/kg (n = 13), 4 mg/kg (n = 8), and 5 mg/kg (n = 8). Intraoperatively, NIR imaging was performed. The endpoint was to identify the highest tumor-to-background fluorescence ratio (TBR) for each tumor type at each dose. Final pathology confirmed tumor histology. Results Of 45 patients, 41 had malignancies (18 non-small cell lung cancers [NSCLC], 3 pulmonary neuroendocrine tumors, 13 thoracic metastases, 4 thymomas, 3 mesotheliomas). At doses of 4 to 5 mg/kg, the TBR from primary NSCLC vs other malignancies was no different (2.70 vs 3.21, p = 1.00). At doses of 1 to 3 mg/kg, the TBR was greater for the NSCLCs (3.19 vs 1.49, p = 0.0006). Background fluorescence from the heart or ribs was observed in 1 of 16 cases at 1 to 2 mg/kg, 5 of 13 cases at 3 mg/kg, and 14 of 16 cases at 4 to 5 mg/kg; this was a major determinant of dose optimization. Conclusions This is the first study to demonstrate that the optimal NIR contrast agent dose varies by tumor histology. Lower dose ICG (2 to 3 mg/kg) is superior for nonprimary lung cancers, and high dose ICG (4 to 5 mg/kg) is superior for lung cancers. This will have major implications as more intraoperative imaging trials surface in other specialties, will significantly reduce costs and may facilitate wider application.
Feeding Tube Insertion and Placement Confirmation Using Electromagnetic Guidance: A Team Review.

Background Challenges for bedside placement of small-bore feeding tube (SBFT) include iatrogenic injury, multiple exposures to x-rays, and prolonged placement times. In 2011, the study facility began a feeding tube placement team (FTPT) using the CORTRAK system (CS) in the adult intensive care unit (ICU) and medical-surgical populations. In 2013, a protocol was implemented using the CS to determine final SBFT location. Methods Serial retrospective reviews were done of patients with SBFT placement by the FTPT during July 2011-December 2012 and 2015. Measures included pulmonary deviation, tube location, placement agreement beyond chance for CS tracing and confirmation radiography (CR), x-ray frequency, and placement time intervals. Results A total of 6290 SBFT placements were completed for 4239 patients. First-attempt SBFT locations were 12.78% gastric, 13.39% first through fourth portion of duodenum, and 73.83% ligament of Treitz/jejunum, with zero placements in esophagus or lung. In 2015, staff avoided 68 lung placements by recognizing proximal pulmonary deviation. X-ray preprotocol vs protocol (mean [SD]: 1.02 [0.15] vs 0.26 [0.44]) resulted in 74% x-ray reduction and cost avoidance of $346,000. Time intervals (mean [SD]; N = 6290) were 14.90 (12.74) minutes for insertion, 46.04 (13.80) minutes for placement event, and 3.85 (2.23) hours for consult conclusion. Agreement for n = 1692 placements was 85.28%, with k score of 0.622 (95% confidence limit: 0.582, 0.661; P = .0005). Conclusions Team management of SBFT placement using the CS optimizes patient safety, standardizes practice, and decreases cost. Using the CS to determine final SBFT location is a safe alternative to CR.
Simulations of fracture tests of uncharged and hydrogen-charged additively manufactured 304 stainless steel specimens using cohesive zone modeling

Abstract Fracture tests of uncharged and hydrogen-charged single edge bend specimens of additively manufactured 304 stainless steels are simulated using the cohesive zone modeling (CZM) approach. Two-dimensional plane strain finite element analyses without cohesive elements are conducted to identify the values of cohesive energy. Similar analyses using CZM with the trapezoidal traction-separation laws are then conducted. The best-fit cohesive parameters show the values of cohesive strength for the uncharged specimens are higher than those for the hydrogen-charged ones whereas the value of cohesive energy for the uncharged specimens can be either slightly lower or higher than that for the hydrogen-charged ones.
Reduced stress response in juvenile Chinook Salmon reared with structure

Abstract Understanding how rearing environments influence the stress response is relevant to many fish management practices. This is particularly relevant in aquaculture, where it is important to be able to minimize the effects of stress to enhance animal wellbeing. The stress response is also interesting from a basic science perspective, where it is important to understand how environmental differences can influence phenotypic traits and the physiological reaction to stressors. We tested the hypothesis that rearing fish in a more complex environment would reduce their stress response when presented with stressors. Specifically, we tested for the effect of structure in rearing tanks on the stress response of juvenile Chinook Salmon (Oncorhynchus tshawytscha) exposed to a handling and crowding stressor, something like hatchery fish might experience during transportation to new locations. For both rearing treatments (with and without structure), we compared fish that were subjected to the stressor to fish sampled from the respective rearing tank as the control. For the stressed treatment, we subjected fish to net capture followed by three hours in lowered water levels in a novel tank and then moved to a second novel holding tank. This process was designed to mimic typical stressors fish may experience at a hatchery. We analyzed plasma collected before the start of the stressor, during the stressor, and throughout 20 h post-stressor for cortisol in both stressed and unstressed fish. For both rearing treatments, fish that experienced the stressor had elevated plasma cortisol compared to control fish. However, the cortisol levels of fish in the stressed treatment reared with structure were significantly less than fish reared without structure. Additionally, plasma cortisol levels in structure-reared fish returned to baseline by 20 h post-stress while fish reared without structure had not fully recovered. Our findings suggest that increasing complexity of the rearing environment might be advantageous as a way of minimizing effects of handling-type stressors.
Correction to: Divorce among European and Mexican immigrants in the U.S.

The original version of this article unfortunately contained few errors in tables. In Tables 2a, 2b, 3a and 3b, the “Percent of sample” and “Percent spouse absent” should be in decimal in order to be consistent. In Tables 4 and 5, the first row should read as “Age at marriage” instead of “Percent of sample” and the “Sample size” was incorrect.
Outsiders’ Responsibility to Answer for Crime

R. A. Duff has revived the tradition of “answerability” for crime. In this philosophical and jurisprudential tradition, a person is answerable to the criminal law of a state and the process of that state’s courts only if there is some appropriate relationship between the state and the person. Duff’s great contribution has been to develop the idea of accountability of persons to a state or other polity as a philosophical notion which, he argues, underlies all just implementations of criminal law. Duff has centered his views around the relationship between the citizen and the polity (in today’s world, the state) to which the citizen belongs. His focus has been on insiders, rather than outsiders. This article argues that, in the current world, the relationship among cocitizens, outsiders, and the state is based in part on the moral idea that the state exists to protect citizens from evil acts, specifically those that we call public and criminal wrongs, wherever the acts originate. Outsiders understand this, and understand that states other than their own use criminal law to protect their citizens. Duff’s writings contain an idea which turns out to be very useful in cases of outside acts, even though he does not apply it directly to them. Some states or other entities may have only an incomplete relationship with an accused person (compared with the relationship of citizen and state), but nonetheless may have the moral and political authority to try her for crime. This paper extends this notion to show that such incomplete relationships exist in a great many common cases of outsiders (noncitizens who act outside the territory of a state) who commit crime. These relationships support criminal prosecution of outsiders, so long as we admit that protection of persons from crime is a legitimate goal of the criminal law.
Environment-Sensitive Azepane-Substituted β-Diketones and Difluoroboron Complexes with Restricted C–C Bond Rotation

Luminescent β-diketones (bdks) and difluoroboron coordinated complexes (BF₂bdks) exhibit many environment-sensitive properties, such as solvatochromism, viscochromism, aggregation-induced emission (AIE), and thermal and mechanochromic luminescence (ML). In a previous study, an azepane-substituted bdk ligand (L1) and boron dye (D1) showed noteworthy luminescence properties but low quantum yields (Φ, L1: 0.26; D1: 0.02) due to free intramolecular bond rotation and twisted intramolecular charge transfer state formation with associated nonradiative decay. Thus, in order to improve the quantum yields, an azepane-substituted bdk ligand (L2) and boron complex (D2) with restricted C–C bond rotation were synthesized, and various luminescence properties were investigated. Restricting bond rotation blue-shifted absorptions and emissions, increased lifetimes, and greatly improved quantum yields (Φ, L2: 0.47; D2: 0.83). Excited state density functional theory calculations displayed twisted geometries for L1 and D1 but more planar geometries for L2 and D2. All compounds showed red-shifted emissions in more polar solvents. For viscochromism, L1 and D1 exhibited higher emission intensity in more viscous media. However, L2 and D2 did not show dramatic viscochromism, substantiating the relation between viscosity sensitivity and intramolecular bond twisting. Additionally, while both ligands showed quenched emission upon aggregation, the dyes exhibited AIE regardless of bond restriction. Thermal and ML studies showed a more dramatic emission shift for L2 than L1 between thermally annealed and melt-quenched states. In summary, the quantum yields of the azepane-substituted bdk ligand and boron dye were successfully improved by restricting the intramolecular C–C bond rotation, making various luminescence properties more promising for environment-sensitive applications.
ProCSA: Protecting Privacy in Crowdsourced Spectrum Allocation

Sharing a spectrum is an emerging paradigm to increase spectrum utilization and thus address the unabated increase in mobile data consumption. The paradigm allows the “unused” spectrum bands of licensed primary users to be shared with secondary users, as long as the allocated spectrum to the secondary users does not cause any harmful interference to the primary users. However, such shared spectrum paradigms pose serious privacy risks to the participating entities, e.g., the secondary users may be sensitive about their locations and usage patterns. This paper presents a privacy-preserving protocol for the shared spectrum allocation problem in a crowdsourced architecture, wherein spectrum allocation to secondary users is done based on real-time sensing reports from geographically distributed and crowdsourced spectrum sensors. Such an architecture is highly desirable since it obviates the need to assume a propagation model, and facilitates estimation based on real-time propagation conditions and high granularity data via inexpensive means.
The Future of Learning and the Future of Assessment

Purpose:The aim of this article is to point out that assessment should serve as useful information about the development of learners’ capabilities, but not define, measure, evaluate, and confer “me...
A case of metastatic pancreatic adenocarcinoma confounded by complementary and alternative medicine therapies

The use of complementary and alternative medicine (CAM) among cancer patients is widespread. Using these therapies may lead to treatment delays or confound the clinical picture when problems arise. Inquiry regarding CAM therapies used is an important part of a thorough history for any cancer patient. A 48-year-old man with a history of stage IV pancreatic adenocarcinoma was referred for a second opinion for a worsening dry cough in the setting of cavitary ground-glass opacities and non-cavitating nodules found on chest CT. Previous workup was non-diagnostic and his CT findings were atypical for pulmonary metastasis. Due to his extensive alternative therapy use, he was diagnosed with interstitial lung disease (ILD). Flexible bronchoscopy with transbronchial cryobiopsies revealed adenocarcinoma with intestinal/pancreatobiliary differentiation, consistent with metastatic pancreatic cancer. Adjacent alveolar parenchyma was without evidence of ILD. Atypical CT patterns of pulmonary metastasis should lead to an investigation regarding other possible causes.
Examining soccer fan performances through performative sport fandom theory: how fans of the spurs perform their fandom

This study examined fan performances of the Tottenham Hotspur football club located in London, England. Through Performative Sport Fandom theory, this study uncovers how fans of the Spurs perform t...
Democratically engaged community-university partnerships: Reciprocal determinants of democratically oriented roles and processes

A relatively new conception of engagement provides a framework by which institutions of higher education engage with communities in democratic ways, which include inclusive, reciprocal problem-oriented work that brings together university and community stakeholders as co-generators of knowledge. The resulting democratically engaged partnerships position diverse members to take on roles as collaborators and problem solvers. They are mutually transformed through the processes of reciprocation, power diffusion, and knowledge generation. How these roles and processes emerge is unknown. Neither the literature on democratic engagement nor that on community–university partnerships address this gap. Using a purposefully selected community–university partnership that has a high degree of democratic engagement, evidence was collected of the ways in which the roles and processes of democratically engaged partnerships were enacted. Of particular interest were the blend of democratic and technocratic characteristics present, the critical role of orienting new partners, and the role of leadership in promoting a democratic orientation.
Performance Tradeoffs Revealed by Multi-Objective Optimization of Multi-Layered Core-Shell Nanoparticles

Tailoring the resonant behaviors of multi-layer core-shell nanoparticles can be achieved by tuning their material and geometrical parameters (i.e., the relative radii ratio and constituent material parameters in each layer). To this end, one may apply an optimization procedure in order to find the optimal particle configuration that achieves the desired behavior. When multiple performance objectives exist, one can apply multi-objective algorithms in order to simultaneously optimize each objective and study the tradeoffs between them. In this paper, the dependence on scattered field directivity as a function of the excited scattered field coefficients is studied and an inverse-design problem is proposed in order to find multi-layer nanoparticle configurations which achieve highly-directive behaviors.
The creatine kinase conundrum: a reappraisal of the association of isotretinoin, creatine kinase, and rhabdomyolysis.

Background Isotretinoin has been reported to elevate creatine kinase, which may lead to fatal rhabdomyolysis. Objective To review the literature and propose practice guidelines for management of elevated creatine kinase during isotretinoin therapy. Findings Patients have intrinsic and extrinsic qualities that may synergistically work with isotretinoin to elevate serum creatine kinase. Darker skin types and males on isotretinoin are more likely to have elevated creatine kinase. Isotretinoin may induce oxidative stress within muscle tissue, thereby leading to elevations in serum creatine kinase. Conclusion Evidence supports a tenuous correlation between isotretinoin, elevated creatine kinase, and exercise. Physicians should consider obtaining baseline creatine kinase on elite athletes and counseling patients on risk factors that may elevate creatine kinase. However, the potential for elevated CK is not a contraindication for isotretinoin therapy.
Policy implications of truck platooning and electrification

Abstract Trucks in North America account for more than 23% of the transportation sector's greenhouse gas emissions. Truck platooning and truck electrification are potential technologies for reducing emissions and operating cost. However, adoption uncertainties result in speculations about their potential impact. Traditional modeling techniques to inform policymaking use large datasets, trained professionals to calibrate complex software, and take hours to run a single scenario. This paper provides a closed-form model that rapidly calculates trends of the potential national petroleum consumption reduction for a range of technology adoption scenarios. The primary finding is that truck electrification would have a substantially larger impact on fuel consumption reduction than platooning. The limitations of platoonable miles create an upper bound in benefits. When calibrated for the base year fuel-efficiency, the model shows that petroleum consumption reduction would be less than 4% at full adoption of platooning. The electrification of single unit trucks results in more than a 13-fold reduction of national petroleum consumption relative to platooning. However, without the electrification of combination unit trucks, petroleum consumption will eventually begin to increase again. Therefore, policies to encourage the reduction of greenhouse gas emissions should not overlook incentives to electrify combination unit trucks.