cssi/SciSciGPT-SciSciNet huggingface dataset:
A Geometric Framework for Monitoring and Fault Detection for Periodic Processes

This paper focuses on data-driven monitoring and fault detection for processes subject to periodic operation. Although cyclical operation systems are relatively widespread in practice (notably in the realm of physical separations, e.g., pressure-swing adsorption and chromatography), the development of specific fault detection mechanisms has received little attention compared to the extensive efforts dedicated to continuous or batch processes. Here, we propose a novel geometric approach for process fault detection. Specifically, we develop a time-explicit multivariable representation of data collected from the process, which provides a natural framework for defining “normal” operation and the corresponding confidence regions. On this basis, we proceed with a two-step fault detection approach, based on detecting inter-cycle variations to locate a faulty cycle, and intra-cycle changes to determine the exact timing of a fault. We illustrate the theoretical developments with two simulation case studies. This article is protected by copyright. All rights reserved.
Exercise performance and physiological responses: the potential role of redox imbalance.

Increases in oxidative stress or decreases in antioxidant capacity, or redox imbalance, are known to alter physiological function and has been suggested to influence performance. To date, no study has sought to manipulate this balance in the same participants and observe the impact on physiological function and performance. Using a single-blind, placebo-controlled, and counterbalanced design, this study examined the effects of increasing free radicals, via hyperoxic exposure (FiO2 = 1.0), and/or increasing antioxidant capacity, through consuming an antioxidant cocktail (AOC; vitamin-C, vitamin-E, α-lipoic acid), on 5-kilometer (km) cycling time-trial performance, and the physiological and fatigue responses in healthy college-aged males. Hyperoxic exposure prior to the 5 km TT had no effect on performance, fatigue, or the physiological responses to exercise. The AOC significantly reduced average power output (222 ± 11 vs. 214 ± 12 W), increased 5 km time (516 ± 17 vs. 533 ± 18 sec), suppressed ventilation (VE; 116 ± 5 vs. 109 ± 13 L/min), despite similar oxygen consumption (VO2; 43.1 ± 0.8 vs. 44.9 ± 0.2 mL/kg per min), decreased VE/VO2 (35.9 ± 2.0 vs. 32.3 ± 1.5 L/min), reduced economy (VO2/W; 0.20 ± 0.01 vs. 0.22 ± 0.01), increased blood lactate (10 ± 0.7 vs. 11 ± 0.7 mmol), and perception of fatigue (RPE; 7.39 ± 0.4 vs. 7.60 ± 0.3) at the end of the TT, as compared to placebo (main effect, placebo vs. AOC, respectively). Our data demonstrate that prior to exercise, ingesting an AOC, but not exposure to hyperoxia, likely disrupts the delicate balance between pro- and antioxidant forces, which negatively impacts ventilation, blood lactate, economy, perception of fatigue, and performance (power output and 5 km time) in young healthy males. Thus, caution is warranted in athletes taking excess exogenous antioxidants.
Numerical stabilities of loosely coupled methods for robust modeling of lightweight and flexible structures in incompressible and viscous flows

The growing interest to examine the hydroelastic dynamics and stabilities of lightweight and flexible materials requires robust and accurate fluid–structure interaction (FSI) models. Classically, partitioned fluid and structure solvers are easier to implement compared to monolithic methods; however, partitioned FSI models are vulnerable to numerical (“virtual added mass”) instabilities for cases when the solid to fluid density ratio is low and if the flow is incompressible. As a partitioned method, the loosely hybrid coupled (LHC) method, which was introduced and validated in Young et al. (Acta Mech. Sin. 28:1030–1041, 2012), has been successfully used to efficiently and stably model lightweight and flexible structures. The LHC method achieves its numerical stability by, in addition to the viscous fluid forces, embedding potential flow approximations of the fluid induced forces to transform the partitioned FSI model into a semi-implicit scheme. The objective of this work is to derive and validate the numerical stability boundary of the LHC. The results show that the stability boundary of the LHC is much wider than traditional loosely coupled methods for a variety of numerical integration schemes. The results also show that inclusion of an estimate of the fluid inertial forces is the most critical to ensure the numerical stability when solving for fluid–structure interaction problems involving cases with a solid to fluid-added mass ratio less than one.
Treatment of Premature Ejaculation

Oral drug treatment for PE has been available since 1932 when Bernard Schapiro developed Prajaculin for the treatment of lifelong PE, which was even more than a decade before the first review article on PE was published by Schapiro in 1943 and long before behavioral treatments were advocated as the first choice of treatment. However, it was only after the introduction of the selective serotonin reuptake inhibitors (SSRIs) in the early 1990s that drug treatment of PE became revolutionized. Lack of an operationalized definition of PE and the absence of an objective measure of the ejaculation time hampered a truly scientific approach to investigate the efficacy of drugs in delaying ejaculation. Waldinger et al. introduced in 1994 the intravaginal ejaculation latency time (IELT) as a standardized measure of the ejaculation time. Various drugs are currently available for the treatment of PE, but all of them, except dapoxetine, are off-label. This chapter will discuss current treatments of PE with their advantages and disadvantages including daily treatment with SSRIs, on-demand treatment with oral drugs and topical anesthetics, and psychosocial treatments.
Democratic engagement through the ethic of passionate impartiality

Building on conceptions of democratic engagement, we explicate the epistemological and political commitments of engaged scholarship tied to deliberative democracy that responds to the neutrality challenge of doing impactful political work without advocating for a particular political position. The Colorado State University Center for Public Deliberation (CPD) provides a model of democratic engagement by serving as an impartial resource for its community, in part by training students to be facilitators of public processes. This type of democratic engagement can cultivate mutual benefits for students, professors, universities, community organizations, and citizens. We offer a principle of passionate impartiality for guiding process-design and facilitation. Passionately impartial scholars and students are passionate about their community, democracy, and solving problems but are nonetheless committed to serving a primarily impartial, process-focused role in order to improve local communication practices. Drawing on challenges from critical theory and the academy, we offer a nuanced account of what it means to negotiate the tensions between serving an impartial role while also upholding democratic values of equality and inclusion.
Abstract CT078: Impact of disease burden and transplant on long-term survival after CD19 CAR therapy in adults with relapsed B-cell acute lymphoblastic leukemia

Objectives: CD19-specific chimeric antigen receptor (CAR) T cells have demonstrated high initial responses in patients with relapsed B-cell acute lymphoblastic leukemia (B-ALL). However, clinical characteristics associated with the durability of response remain undefined. Herein, we report the results from analysis of our phase I clinical trial of 19-28z CAR T cells in adult patients with relapsed B-ALL with a focus on impact of pre-treatment disease burden and post-CAR T cell allogeneic transplant on long-term clinical outcome. Methods: Adults with relapsed B-ALL were infused with autologous T cells expressing the 19-28z CAR. Disease burden was assessed by bone marrow biopsy immediately prior to T cell infusion. We grouped patients into 2 cohorts based on disease burden upon T cell infusion: minimal residual disease (MRD) with Results: 51 adults received 19-28z CAR T cells; 20 in the MRD and 31 in the morphologic cohort. Complete remission (CR) rates were comparable (95% and 77%, respectively). However, median event-free and overall survivals widely diverged among the 42 patients who achieved MRD-negative CR: not reached (NR) (95% confidence interval [CI]: 4.2-NR) vs. 6.3 months (95% CI, 4.8-9.0) (p=0.0005), and NR (95% CI, 15.3-NR) vs. 17 months (95% CI, 8.5 - 36.2) (p=0.0189), in the MRD and morphologic cohorts, respectively. Subsequent allogeneic HSCT in either cohort did not improve survival (p=0.8). MRD cohort patients developed substantially less severe cytokine release syndrome (CRS) and neurotoxicity, both correlating with peak CAR T cell expansion (p=0.0326 and p=0.0001, respectively). Conclusion: Despite comparable initial CR rates between the two cohorts, durability of 19-28z CAR T cell mediated remissions and survival in adult patients with relapsed B-ALL positively correlated to a low disease burden and do not appear to be enhanced by allogeneic transplant. Our findings strongly support the early incorporation of CD19 CAR therapy before morphologic relapse in B-ALL. Citation Format: Jae H. Park, Isabelle Rivere, Xiuyan Wang, Brigitte Senechal, Kevin Curran, Craig Sauter, Yongzeng Wang, Bianca Santomasso, Daniel Li, Renier Brentjens, Michel Sadelain. Impact of disease burden and transplant on long-term survival after CD19 CAR therapy in adults with relapsed B-cell acute lymphoblastic leukemia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr CT078. doi:10.1158/1538-7445.AM2017-CT078
A review of the literature on pediatric concussions and return-to-learn (RTL): Implications for RTL policy, research, and practice.

OBJECTIVE: While reintegration of concussed youth back into sports has been increasingly studied over the past decade, a noticeably lacking yet growing body of research has begun to focus on issues surrounding return to academics or "return-to-learn" (RTL). The objective of this article was to conduct a comprehensive literature review to identify the full range of themes and gaps in the current body of RTL research. STUDY DESIGN: Researchers analyzed PubMed, PsycINFO, and ERIC databases to identify all recent (January 2000 through May 2016) empirical publications on the RTL process following youth concussions. In addition to the database searches, bibliographies of selected manuscripts were hand-searched for additional sources. RESULTS: A total of 35 articles met inclusion criteria. Key themes identified from the RTL literature centered on academic outcomes, physician recommendations, length of time to complete RTL, concussion-related symptom difficulties, and academic accommodations/guidelines. Across these areas, the research was fairly inconsistent in terms of providing clear conclusions, likely because of the small number of studies conducted within these areas as well as variability in methodology and terminology. Gaps in the research include a lack of the following: consensus on RTL protocols, agreement on prescription of cognitive rest, guidance for RTL legislation, understanding of communication between systems of care, concussion-related education for systems of care, evidence-based programs or interventions for RTL, and the impact on RTL outcomes. CONCLUSIONS: Given the inconsistencies in RTL literature, more rigorous research is needed to inform concussion policy and practice to assist with pediatric concussion management. (PsycINFO Database Record(c) 2017 APA, all rights reserved). Language: en
Love flows downstream: mothers' and children's neural representation similarity in perceiving distress of self and family.

The current study aimed to capture empathy processing in an interpersonal context. Mother-adolescent dyads (N = 22) each completed an empathy task during fMRI, in which they imagined the target person in distressing scenes as either themselves or their family (i.e. child for the mother, mother for the child). Using multi-voxel pattern approach, we compared neural pattern similarity for the self and family conditions and found that mothers showed greater perceptual similarity between self and child in the fusiform face area (FFA), representing high self-child overlap, whereas adolescents showed significantly less self-mother overlap. Adolescents' pattern similarity was dependent upon family relationship quality, such that they showed greater self-mother overlap with higher relationship quality, whereas mothers' pattern similarity was independent of relationship quality. Furthermore, adolescents' perceptual similarity in the FFA was associated with increased social brain activation (e.g. temporal parietal junction). Mediation analyses indicated that high relationship quality was associated with greater social brain activation, which was mediated by greater self-mother overlap in the FFA. Our findings suggest that adolescents show more distinct neural patterns in perceiving their own vs their mother's distress, and such distinction is sensitive to mother-child relationship quality. In contrast, mothers' perception for their own and child's distress is highly similar and unconditional.
Fifteen minutes of unwanted fame: detecting and characterizing doxing

Doxing is online abuse where a malicious party harms another by releasing identifying or sensitive information. Motivations for doxing include personal, competitive, and political reasons, and web users of all ages, genders and internet experience have been targeted. Existing research on doxing is primarily qualitative. This work improves our understanding of doxing by being the first to take a quantitative approach. We do so by designing and deploying a tool which can detect dox files and measure the frequency, content, targets, and effects of doxing on popular dox-posting sites. This work analyzes over 1.7 million text files posted to paste-bin.com, 4chan.org and 8ch.net, sites frequently used to share doxes online, over a combined period of approximately thirteen weeks. Notable findings in this work include that approximately 0.3% of shared files are doxes, that online social networking accounts mentioned in these dox files are more likely to close than typical accounts, that justice and revenge are the most often cited motivations for doxing, and that dox files target males more frequently than females. We also find that recent anti-abuse efforts by social networks have reduced how frequently these doxing victims closed or restricted their accounts after being attacked. We also propose mitigation steps, such a service that can inform people when their accounts have been shared in a dox file, or law enforcement notification tools to inform authorities when individuals are at heightened risk of abuse.
Using Data Mining to Analyze High School AP Exam Pass Fail Rates

This study uses data mining analytics techniques including trained multiple regression models to identify the predictors of AP pass rates in CA public high schools using publicly available data from the State of California's Department of Education website. The independent variables included in the analysis explored the relationship of elementary and middle school characteristics such as Math and English Language Arts (ELA) test scores, as well as the degree of poverty at a school represented by the percentage of students qualifying for Free and Reduced-Price Meals (FRPM). Other variables considered were the percentage of English Language Learners (ELL's), the size of the school, special curricular programs (IB program, dual language), whether the school was a charter or traditional public school, as well as the age of the school. The multiple regression model and exploratory correlational analysis, highlighted interaction effects of two key variables, FRPM and ELL's. Our final results indicated that, higher 3rd grade math scores offered some mediating effects protecting against the negative effect of high levels of FRPM and ELL students at a school. 3rd grade Math scores were the best predictor of high school AP pass rates. Unfortunately, the effect of 3rd grade mean math scores was not high enough to completely cancel out the effects of high rates of poverty or being an English language learner.
Prisoners as Parents: The Importance of Strong Parent-Child Relationships During Parental Incarceration

A parent's incarceration profoundly impacts both her and her children. This paper will highlight some issues resulting from parental incarceration and suggest a program the California Department of Corrections and Rehabilitation (CDCR) can implement to confront these issues. Parental incarceration affects everyone in California because of the sheer number of families involved and the implications parental incarceration has on the development of the next generation of Californians.
Rapid generation of nested deletions by differential restriction digestion.

A method was devised for generating nested deletions in DNA that exploits the difference in frequency of restriction sites recognized by compatible restriction endonucleases. A cloning vector was c...
Anale intraepitheliale Neoplasie

Die anale intraepitheliale Neoplasie (AIN) ist haufig kondylomassoziiert und kann in 3 Grade eingeteilt werden. Diese Neoplasien konnen unbehandelt in ein Karzinom ubergehen.
Potential underuse of repeat resection among patients with high-grade non-muscle invasive bladder cancer.

e16028Background: For patients diagnosed with non-muscle invasive bladder cancer (NMIBC), guidelines recommend that those with high-grade (HG) T1 disease and potentially those with lower risk HG Ta...
An Efficient Transformation Scheme for Lossy Data Compression with Point-Wise Relative Error Bound

Because of the ever-increasing execution scale of scientific applications, how to store the extremely large volume of data efficiently is becoming a serious issue. A significant reduction of the scientific data size can effectively mitigate the I/O burden and save considerable storage space. Since lossless compressors suffer from limited compression ratios, error-controlled lossy compressors have been studied for years. Existing error-controlled lossy compressors, however, focus mainly on absolute error bounds, which cannot meet users' diverse demands such as pointwise relative error bounds. Although some of the state-of-the-art lossy compressors support pointwise relative error bound, the compression ratios are generally low because of the limitation in their designs and possible spiky data changes in local data regions. In this work, we propose a novel, efficient approach to perform compression based on the pointwise relative error bound with higher compression ratios than existing solutions provide. Our contribution is threefold. (1) We propose a novel transformation scheme that can transfer the pointwise relative-error-bounded compression problem to an absolute-error-bounded compression issue. We also analyze the practical properties of our transformation scheme both theoretically and experimentally. (2) We implement the proposed technique in two of the most popular absolute-error-bounded lossy compressors, SZ and ZFP. (3) We evaluate our solution using multiple real-world application data across different scientific domains on a supercomputer with up to 4,096 cores and 12 TB of data. Experiments show that our solution achieves over 1.38X dumping and 1.31X loading performance over the second-best lossy compressor, respectively.
Abstract WP275: Much Work to Do: Analysis of Potential Performance Measures for Patients Transferred for Acute Endovascular Thrombectomy

Background: Potential performance measures to assess care of acute ischemic stroke patients transferred from initial hospitals to interventional centers for thrombectomy include: 1) door-in to door...
Distinguishing Characteristics among Exemplary Trainers in Business and Industry.

This article reports on a study of trainers in business and industry. The objective of the research was to describe using behavioral and attitudinal terms, the characteristics that differentiate exemplary instructors from average instructors. The research was conducted in fifteen organizations representing a variety of business and industrial settings in Illinois and Indiana. A research team interviewed a nominated group of exemplary trainers and a comparison group of average trainers. Extremely detailed accounts of high points and low points in recent teaching experiences (i.e., critical incidents) were elicited from each person. The research team then conducted an inductive content analysis of the approximately one hundred fifty self-reported critical incidents. The research results reported include a description of the characteristics which differentiated the exemplary trainers from the average trainers.
towards stem cell therapy of polycystic ovary syndrome (PCOS): therapeutic effect of human mesenchymal stem cells transplantation in pcos mouse model by regulating ovarian vascularization

Background & Aim Background Women with the polycystic ovarian syndrome (PCOS) have an increase in ovarian androgen production. Recent studies report that angiogenesis is aberrantly increased in ovaries of PCOS patients. Angiogenesis play an important role in inflammatory response as well as it might be promoted by inflammation as well. We have recently reported that intra-ovarian implanted human mesenchymal stem cells (hMSCs) can decrease serum androgen levels in a PCOS animal model. However, it is still unknown how hMSCs exert its effect on PCOS ovary. The hMSCs are well known regulator of inflammatory response and angiogenesis. These abilities of hMSCs could be strong candidate to explain the mechanism of how they reverse the phenotype of PCOS. Hypothesis We hypothesis that hMSCs can reverse PCOS ovary into normal phenotype by regulating inflammatory response and blood vessel formation. Methods, Results & Conclusion Material and Method In this study, we induced PCOS in C57/BL6 mice by daily Letrozole from week 4 to week 9 of age. We then engrafted hMSCs (500,000 cells/ovary) by direct intra-ovarian injection. 2 weeks later, we sacrificed the mice and collected the ovaries to analyze the inflammatory markers IL-6, IL-1α, the angiogenesis markers VEGFA, ANGPT1, and the blood vessels markers αSMA, vWF by PCR, immunohistochemistry and western blot examination. Result Implantation of hMSCs significantly suppressed the levels of IL-6 and IL-1α (P Conclusion Our data reveal that ovary of letrozole induced PCOS mouse showed increased inflammation and angiogenesis compared to healthy controls. This alteration can be reversed by intra-ovarian hMSCs transplantation. Our study showed that hMSCs injection in PCOS ovaries can normalize inflammatory status and angiogenesis and may present a novel treatment modality for PCOS patients.
ExperTwin: An Alter Ego in Cyberspace for Knowledge Workers

Even though the advent of the Web coupled with powerful search engines has empowered the knowledge workers to quickly find the needed information, it still is a time-consuming operation. Presently there are no readily available tools that can create and maintain an up-to-date personal knowledge base that can be readily consulted when needed. While organizing the entire Web as a semantic network is a long-term goal, creation of a semantic network of personal knowledge sources that are continuously updated by crawlers and other devices is an attainable task. We created an app titled ExperTwin, that collects personally relevant knowledge units (known as JANs) from the Web, Email correspondence, and locally stored files, organize them as a semantic network that can be easily queried and visualized in many formats - just in time - when performing a knowledge-based task. The architecture of ExperTwin is based on the model of a “Society of Intelligent Agents”, where each agent is responsible for a specific task. Collection of JANs from multiple sources, establishing the relevancy, and creation of the personal semantic network are some of the many tasks performed by the individual agents. Tensorflow and Natural Language Processing (NLP) tools have been implemented to let ExperTwin learn from users. Document the design and deployment of ExperTwin as a “Knowledge Advantage Machine” able to search for relevant information while performing a knowledge-based task, is the main goal of the research presented in this paper.
Varying Opportunities to Respond to Improve Behavior of Elementary Students with Developmental Disabilities.

This study investigated the effects of varying opportunities to respond when using a behavior management program with three elementary school students with developmental disabilities in a small group special education setting. These students exhibited both academic and behavioral difficulties. With the implementation of Class-Wide Function-Related Intervention Teams (CW-FIT) with low opportunities to respond (OTR), students increased their active engagement and correct responses, as well as decreased their disruptive behaviors. When CW-FIT with high OTR was implemented, students showed an even greater improvement than CW-FIT with low OTR. Higher rates of OTR resulted in higher levels of active engagement and correct responses and decreases in disruptive behavior for all three students. These results indicate that CW-FIT in combination with high OTR can help elementary school teachers manage students’ behavior and increase students’ correct responding when implemented in a small group special education setting.
Nudges and Norms in Multidistrict Litigation: From Fact Sheets to Lone Pine Orders

On paper, the Federal Rules of Civil Procedure apply equally to billion-dollar opioid allegations and small-stakes claims for $75,000.01. In practice, however, judges and attorneys in high-stakes multidistrict proceedings like those over opioids have invented a smattering of procedures that you’ll never find indexed in the Federal Rules: plaintiff fact sheets, short form complaints, science days, bellwether trials, census orders, inactive dockets, and Lone Pine orders to name but a few. In a world where settlement is the prevailing currency, norms take root. But as norms blossom, the stabilizing features of the federal rules—balance, predictability, and structural protections—can wither. As safeguards atrophy and transferee judges actively nudge the parties to settle, the deals that emerge may reflect the scars of creative pruning, not the suit’s merits. This Essay responds to Nora Engstrom by introducing empirical data on her target (Lone Pine orders) and her remedy (plaintiff fact sheets). Examining these innovations in the lifecycle of products-liability multidistrict litigation illustrates that norms can undermine a key aim of the federal rules: achieving procedural parity, where discovery burdens and the risks of erroneous decisions fall equally on both parties. Although design choices should respond to case management demands, both short cuts can impact plaintiffs more harshly, upending protections for those who need them most.
A Multidisciplinary Team Approach to Brain and Spine Stereotactic Radiosurgery Conferences: A Unique Institutional Model.

Objective The use of multidisciplinary teams (MDTs) comprised of all members of the patient care team is becoming increasingly popular in the field of oncology. We present a single-center experience exploring the utility and uniqueness of an MDT in the care of patients undergoing brain and spine stereotactic radiosurgery (SRS). Methods The weekly SRS conference brought together neurosurgeons, radiation oncologists, neuroradiologists, physicists, dosimetrists, therapists, advanced practice providers, and trainees in these fields as well as researchers from a variety of disciplines with a goal of optimizing patient care. A survey of 20 conference attendees from 7 different facets of the MDT was conducted for feedback. Results The survey results revealed that most respondents believed the SRS conference increased educational opportunities, provided opportunities for research and collaborations, helped streamline patient care, and was beneficial to their practice. Conclusions We present our institutional MDT model, a framework and workflow that can be incorporated at other large academic centers. We believe that the SRS conference has educational, academic, and patient care value.
The Sal-Like 1 (SALL1) Protein is Highly Expressed in Primary Bone Marrow Cells Derived From Patients with Acute Myeloid Leukemia.

Abstract Abstract 1285 Poster Board I-307 Background SALL1 is a zinc finger transcription factor that maps to chromosome 16q12.1 in humans and chromosome 8D in mice. It is a transcription factor required for kidney development, and is mutated in patients with Townes-Brocks syndrome (TBS). We have created a mouse model of TBS that expresses a truncated SALL1 protein and observed that these mice displayed a syndrome consistent with myelodysplastic syndrome (MDS) that accelerates to acute myeloid leukemia (AML). The purpose of this study was to investigate whether SALL1 is expressed in AML patients. Materials and methods 50 bone marrow (BM) samples obtained from AML patients and 10 BM samples obtained from healthy donors were studied. BM samples were processed immediately upon receipt. Immunohistochemistry was performed on paraffin tissue sections of human BM using an anti-SALL1 antibody. RNA was extracted using the RNeasy Mini Kit (Qiagen). Quantitative RT-PCR was performed using the SYBR Green PCR Master Mix and SALL1 specific primers. SALL1 mRNA expression was normalized to RPL19, a ribosomal housekeeping gene. Western blotting was performed to confirm the presence of SALL1 at the protein level. Two AML cell lines (Kasumi-1 and -3) were also screened for SALL1 expression. Results 44/50 human BM AML samples displayed positive nuclear staining for SALL1. Samples taken from healthy controls showed no evidence of staining. 9/ 9 human BM AML samples showed increased SALL1 mRNA levels as compared to healthy controls with upregulation of SALL1 mRNA levels ranging from 3-fold to 1630-fold. High interpatient variability was observed. On average, SALL1 expression of AML patients was 225.1-fold greater than that of healthy controls (n=9, p=0.004). Western blotting confirmed upregulated SALL1 protein expression in AML BM with no expression seen in healthy controls. No SALL1 mRNA was detected in Kasumi-1 and -3 AML cell lines. i.) The majority of patient samples examined in this study demonstrated positive staining for SALL1. ii.) Consistent with its role as a transcription factor SALL1 histochemical staining was nuclear. iii.) SALL1 is highly expressed in human AML BM on the mRNA as well as on the protein level. iv.) No SALL1 mRNA was detected in AML cell lines. Conclusion Our data in mice and humans link the overexpression of SALL1 to AML. The absence of SALL1 in cell lines and its presence in the BM may indicate that SALL1 is confined to a relatively primitive cell. It is to be speculated that SALL1 has functional significance for the molecular pathogenesis of AML. Further studies to elaborate on its molecular functions and interactions are therefore clearly warranted and being conducted. Disclosures No relevant conflicts of interest to declare.
Luxurious Networks: Salt Merchants, Status, and Statecraft in Eighteenth-Century China

Yuanlian Wu uses official documents, genealogies, stele inscriptions, private letters, and literary anthologies to study the Huizhou salt merchants of Yangzhou within the context of the eighteenth-...
The Optimal Level of Insulation in a Home Attic

The project models the conductive heat loss through the ceiling of a home. Students are led through a sequence of tasks from measuring the area and insulation status of a home to developing several...
Plastic flow and the skyrmion Hall effect.

Skyrmions in chiral magnets are a particle-like texture that has been attracting growing interest due to their novel dynamics and possible applications. Here, we discuss the role of disorder and skyrmion-skyrmion interaction in governing their motion under an external drive.
Demonstration of real-time compensation of atmospheric turbulence by nonlinear phase conjugation

The first demonstration of the correction of atmospheric turbulence by nonlinear phase-conjugation techniques is presented. It is shown that severely distorted and wandering beams can dynamically be corrected to near-diffraction limit and locked to a prescribed spatial position. These experiments were performed over a 100-M rooftop range. A beam is propagated over the range, becoming aberrated, enters a phase conjugator, is conjugated, and retraverses the atmospheric path canceling the aberrations. The conjugate signal is generated by the nonlinear optical process of four-wave mixing in sodium vapor at 5890 A. In this way the conjugate, or time reversed signal, is produced by a process involving no moving parts in contrast to conventional adaptive optics techniques involving deformable mirrors.
Assessment of Obstetrics and Gynecology Residents’ Knowledge of Basic Obstetric Sonography and Psychomotor Evaluation With Motion Analysis Using a Computer-Based Simulator:

Purpose:Evaluate obstetrics and gynecology (OB/Gyn) residents’ current obstetric sonography knowledge, confidence, and psychomotor skills to provide clinical preceptors with a greater understanding...
Ranking and Sparsifying a Connection Graph

AbstractMany problems arising in dealing with high-dimensional data sets involve connection graphs in which each edge is associated with both an edge weight and a d-dimensional linear transformation. We consider vectorized versions of PageRank and effective resistance that can be used as basic tools for organizing and analyzing complex data sets. For example, generalized PageRank and effective resistance can be utilized to derive and modify diffusion distances for vector diffusion maps in data and image processing. Furthermore, the edge-ranking of the connection graphs determined by vectorized PageRank and effective resistance are an essential part of sparsification algorithms that simplify and preserve the global structure of connection graphs. In addition, we examine consistencies in a connection graph, particularly in the applications of recovering low-dimensional data sets and the reduction of noise. In these applications, we analyze the effect of deleting edges with high edge rank.
57. PICTURE PERFECT: USE OF SOCIAL MEDIA IN RESIDENCY MEDICAL EDUCATION

Background Social media has become increasingly common in medical education. Residency programs capitalize on resident use of common social media platforms for information dissemination, recruitment and advocacy. However, its specific use in pediatric residency programs has not been elucidated. Objective These authors sought to evaluate current use of popular social media platforms in pediatric residency programs as well as use of social media platforms by pediatric residency interviewees during recruitment. Method Prior to participating in the 2019 APPD enhanced learning session focused on social media's role in graduate medical education, registrants were asked to complete a five-question pre-session survey through their Instagram accounts. The survey was distributed using the “polls” feature of Instagram. Responses were collected from attendees of the conference and were anonymous. Subsequently, a post-match, anonymous survey was sent to interviewees of the University of California/Children's Hospital of Orange County pediatric residency program during the 2018-2019 recruitment season, of which, one question assessed resources to evaluate the program, including social media platforms. Results 24 of 40 (38%) residency programs surveyed have a residency Instagram account. 31 of 36 (32%) residency programs surveyed have a residency Facebook account. Of the 77 post match survey respondents, 37 (48%) ranked Facebook within their top 6 resources used to research and rank the program. 36 (46%) ranked Instagram within their top 6 resources used to research and rank the program. Conclusions Social media platforms are being utilized by pediatric residency applicants in their evaluation of a residency program, yet a minority of residency programs have dedicated social media platforms. This can potentially be due to learning curve, privacy concerns of violating HIPPA policies, and concerns of compromising the patient-doctor relationship.
Signaling and Quorum Sensing within Biofilms: Which Mechanism Is the Most Probable Means of Communication?

We have recently postulated that certain bacterial cells within their biofilms are equipped with electrically-polarized and elastic helical fibers called amyloid fibrils which allow the cells to transmit electromagnetic (EM) signal to their surrounding environment through mechanical vibration of these fibrils. A novel and theoretical Multiphysics model based on a coupled system of electrical and mechanical structures is proposed here enabling prediction of efficient signal generation in the radio frequency range among the cells. Next, to demonstrate the advantage of EM-based communication, using communication channel theory, we have compared performance of EM signaling with its biochemical counterpart (quorum sensing) and shown that EM signaling provides much higher data rate, 4 to 5 orders of magnitude. Thus, it could be potentially more efficient and a preferred method for communication among cells. In quorum sensing, biological cells release auto-inducers intercepted by the adjacent cells as a purposeful message signal.
Risk-informed multi-criteria decision framework for resilience, sustainability and energy analysis of reinforced concrete buildings

With recent advancement in energy-based sustainable design of building structures, the need for inclusive yet practical models to integrate resilience and sustainability is increasingly recognized....
Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization.

Bacteria are encapsulated by a peptidoglycan cell wall that is essential for their survival1. During cell wall assembly, a lipid-linked disaccharide–peptide precursor called lipid II is polymerized and cross-linked to produce mature peptidoglycan. As lipid II is polymerized, nascent polymers remain membrane-anchored at one end, and the other end becomes cross-linked to the matrix2–4. How bacteria release newly synthesized peptidoglycan strands from the membrane to complete the synthesis of mature peptidoglycan is a long-standing question. Here, we show that a Staphylococcus aureus cell wall hydrolase and a membrane protein that contains eight transmembrane helices form a complex that may function as a peptidoglycan release factor. The complex cleaves nascent peptidoglycan internally to produce free oligomers as well as lipid-linked oligomers that can undergo further elongation. The polytopic membrane protein, which is similar to a eukaryotic CAAX protease, controls the length of these products. A structure of the complex at a resolution of 2.6 A shows that the membrane protein scaffolds the hydrolase to orient its active site for cleaving the glycan strand. We propose that this complex functions to detach newly synthesized peptidoglycan polymer from the cell membrane to complete integration into the cell wall matrix. A membrane protein complex aids the release of newly synthesized peptidoglycan strands from the membrane into the growing cell wall.
Providing Sexuality Training for Psychologists: The Role of Predoctoral Internship Sites

Sexuality education positively impacts health service psychologists’ ability to address sexuality, a vital component of overall health and well-being. There is little information about the integrat...
Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.

The phosphodiesterase PDE4D3 is tethered to the centrosome by Myomegalin (Mmg), a centrosome scaffold protein. Mmg loss dislocates PDE4D3 from the centrosome, leading to local PKA overactivation an...
Position Resolved Beta Particle Detection Using GEM

Portable nuclear imaging devices can be used to guide radio-photo-thermal therapy (PTT) of cancer for better efficacy. In this study, we develop a 100 mm x 100 mm triple layer prototype gas electron multiplier (GEM) detector for beta particle imaging. It consists of one drift layer, three GEM foil layers, and a 1D signal readout board with 2 x 64 channels. The DAQ system consists of readout card, trigger system (pre-amplifier and discriminator) and scalable readout system (SRS). With suppression of the background noise and collimated scanning, a 2D image of a Copper-64 source was successfully acquired. This work paves the way for the development of portable GEM imaging devices to improve the efficacy of Radio-PTT.
Improved bicistronic mammalian expression vectors using expression augmenting sequence element (EASE)

We have recently reported on the isolation of a 5.7 kb segment of Chinese hamster ovary cell genomic DNA, Expression Augmenting Sequence Element (EASE), which when used in bicistronic expression vectors allows the development of stable Chinese hamster ovary cell pools in a five to seven week time period that express high levels of recombinant protein (6–25 μg 10-6 cells/day depending on the protein). In the present study, we have mapped the activity of the EASE to a 2.1 kb region using colony forming assays and developed bicistronic expression vectors with the smaller EASE or control lambda DNA. The recovery of pools expressing the hematopoietic growth factor, FLT3 Ligand, in methotrexate-containing media took 1 to 4 weeks less when using EASE expression vectors compared with control vectors. The cell pools developed with the EASE and control vectors had similar final protein expression levels. Southern blot analysis suggested the expression cassette from the EASE containing vectors integrated in tandem arrays arranged in either head to head or head to tail fashion. By contrast, control vectors appeared to integrate with multiple interruptions to the expression vector. Thus, the EASE, within a bicistronic expression vector, appeared to facilitate tandem vector integration and reduce the time required to develop cell pools for protein expression.
Enterprise alignment and inertia risks during transformation

Enterprise transformations pose inertia and alignment risks at the enterprise, organization, business unit, and individual team levels. Transformation differs from internal change in that the risks escalate significantly given the complex interrelationships between diverse stakeholders across the enterprise and related organizations (e.g., functional units, partners, suppliers, customers, etc.). In this chapter, we review and blend multiple frameworks to provide a more structured approach to understanding and managing large-scale enterprise transformation, focusing on the inertia and alignment challenges in complex socio-technical systems. We illustrate the use and utility of the approach by applying the concepts to a global manufacturer undergoing a disruptive business transformation.
The Evaluation of an Animal Assisted Therapy Intervention for Elders with Dementia inLong-Term Care

Abstract This study examined the effects of animal assisted therapy (AAT) on the social and agitated behaviors of elders with dementia residing in long-term care. A purposefully selected sample of four elders from one skilled nursing facility in a rural community participated in the study. Utilizing an A-B-A-B design, elders were videotaped for 15 minutes each day of the study and two coders tallied the presence and frequency of each of the designated behaviors for each elder. A statistically reliable difference in the social behavior category (t= −29.36, p <.0001) and the total agitated behaviors category (t= 7.05, p <.0001) indicated that the behaviors targeted by the intervention were successfully modified. This intervention demonstrates potential for increasing the quality of life for elders with dementia in long-term care facilities through increasing social and decreasing agitated behaviors.
Aluminum Nanoparticles: Accurate Potential Energy Functions and Physical Properties

In this paper we discuss the development, validation, and application of analytic potential energy functions for simulating Al nanoparticles. We consider six functions, the Ercolessi-Adams, Mei‐Davenport, Sutton‐Chen, and Streitz‐Mintmire functions from the literature and the NP-A and NP-B functions from our group. We find that the NP-A and NP-B potential energy functions, which were fit to a set of 808 energies and geometries for Al clusters and nanoparticles and to a combination of theoretical and experimental data for three bulk phases of metallic Al, are more accurate for Al nanoparticles than are the functions from the literature, which were mainly (but not entirely) parameterized for the bulk. We have used the NP-B potential to simulate liquid Al nanodroplets to study the size dependence of their densities, thermal expansivities, and particle shapes. The nanoparticle densities were computed by first computing the volumes using overlapping van der Waals spheres. We then used the densities to compute the coefficient of thermal expansion for nano-Al droplets; this coefficient was found to increase with increasing particle size. We have also shown that particle shape is size dependent, with smaller particles being prolate spheroids.
The metabolism of labeled parathyroid hormone. VII Attempts to modify hormone deposition.

Using a125I-labeled parathyroid hormone with apparently full biological activity, a series of experiments was performed on rats to determine the effects of several physiological parameters on the deposition and metabolism of the hormone in the target tissues, liver, kidney and bone.
The Atmospheres of Mars and Venus

The nine planets of our solar system can be grouped into two distinct classes: (1) the terrestrial planets, which include Mercury, Venus, Earth and Mars; and (2) the major planets — Jupiter, Saturn, Uranus, Neptune and Pluto.
Magnetic Morphology of Nonthermal Electron Precipitation During Three Flares in a Highly Nonpotential Active Region

NOAA Active region 5747, during its October 1989 transit across the solar disk, showed highly nonpotential photospheric vector magnetic field structure and produced many solar flares, three of which we observed at Mees Solar Observatory. After resolution of the 180° ambiguity, we determined the photospheric distribution of the vertical current density. We then compared the locations of the major current systems to sites of nonthermal electron precipitation inferred from Hα profiles of three flares observed using the Mees CCD Imaging Spectrograph. We found that the sites of energetic electron precipitation are at the edges of these currents, not at their peaks.