cssi/SciSciGPT-SciSciNet huggingface dataset:
The role of novel COQ8B mutations in glomerulopathy and related kidney defects

Background and objectives Glomerulopathies affect kidney glomeruli and can lead to end-stage renal disease if untreated. Clinical and experimental evidence have identified numerous (>20) genetic mutations in the mitochondrial coenzyme Q8B protein (COQ8B) primarily associated with nephrotic syndrome. Yet, little else is understood about COQ8B activity in renal pathogenesis and its role in mitochondrial dysfunction. We identified additional novel COQ8B mutations in a glomerulopathy patient and aimed to define the potential structural and functional defects of COQ8B mutations. Design, setting, participants, and measurements Whole exome sequencing was performed on a Hispanic female presenting with proteinuria. Novel mutations in the COQ8B gene were identified. The effects of mutation on protein function, mitochondrial morphology, and disease progression were investigated by histopathology, transmission electron microscopy, homology modeling, and in silico structural analysis. Results We have characterized the pathophysiology of novel COQ8B mutations, compound heterozygous for two alterations c.1037T>G (p.I346S), and c.1560G>A (p.W520X), in the progression of proteinuria in a Hispanic female. Histopathology revealed defects in podocyte structure and mitochondrial morphology. In silico and computation analyses highlight possible structural origins of COQ8B dysfunction in the presence of mutations. Conclusions Novel mutations in COQ8B present promising biomarkers for the early detection and therapeutic targeting of mitochondrial glomerulopathy. Insights from structural modeling suggest roles of mutation-dependent alterations in COQ8B allosteric regulation, protein folding, or stability in renal pathogenesis.
Abstract 13663: Long-Term Outcome of Cook Formula Stents in Patients With Congenital Heart Disease

Introduction: Cook Formula stents are widely used in pediatric cardiology owing to their low profile and availability in a variety of sizes. Literature regarding the long-term outcome of these sten...
Physical factors contributing to regulation of bacterial surface motility

Microbes routinely face the challenge of acquiring territory and resources on wet surfaces. Cells move in large groups inside thin, surface-bound water layers, often achieving speeds of 30 μm/s within this environment, where viscous forces dominate over inertial forces (low Reynolds number). The canonical Gram-positive bacterium Bacillus subtilis is a model organism for the study of collective migration over surfaces with groups exhibiting motility on length scales three orders of magnitude larger than themselves within a few doubling times. Genetic and chemical studies clearly show that the secretion of endogenous surfactants and availability of free surface water are required for this fast group motility. Here we show that: (i) water availability is a sensitive control parameter modulating an abiotic jamming-like transition that determines whether the group remains fluidized and therefore collectively motile, (ii) groups self-organize into discrete layers as they travel, (iii) group motility does not require proliferation, rather groups are pulled from the front, and (iv) flow within expanding groups is capable of moving material from the parent colony into the expanding tip of a cellular dendrite with implications for expansion into regions of varying nutrient content. Together, these findings illuminate the physical structure of surface-motile groups and demonstrate that physical properties, like cellular packing fraction and flow, regulate motion from the scale of individual cells up to length scales of centimeters.
Tuning the Conductivity of Hexa-Zirconium(IV) Metal-Organic Frameworks by Encapsulating Heterofullerenes

Electrical conductivity in metal–organic frameworks (MOFs) has a great potential for energy storage applications and electrocatalysis. Zirconium-based MOFs such as NU-901 and NU-1000 have a low ele...
Preventing Loss of Independence through Exercise (PLIÉ): A Pilot Trial in Older Adults with Subjective Memory Decline and Mild Cognitive Impairment.

Background Preventing Loss of Independence through Exercise (PLIE) is a group movement program initially developed for people with mild-to-moderate dementia that integrates principles from several well-established traditions to specifically addresses the needs of people with cognitive impairment. Objective To investigate whether PLIE would benefit cognitive and behavioral outcomes and functional brain connectivity in older adults with milder forms of cognitive impairment. Methods Participants (≥55 y) with subjective memory decline (SMD) or mild cognitive impairment (MCI) were assessed with tests of cognitive and physical function, self-report questionnaires, and resting state functional magnetic resonance imaging (rs-fMRI) on a 3 Tesla scanner before and after participating in twice weekly PLIE classes for 12 weeks at the San Francisco Veterans Affairs Medical Center. Results Eighteen participants completed the pre-post intervention pilot trial. We observed significant improvements on the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog; effect size 0.34, p = 0.002) and enhanced functional connections between the medial prefrontal cortex (mPFC) and other nodes of the default mode network (DMN) after PLIE. Improvements (i.e., lower scores) on ADAS-cog were significantly correlated with enhanced functional connectivity between the mPFC and left lateral parietal cortex (Spearman's ρ= -0.74, p = 0.001) and between the mPFC and right hippocampus (Spearman's ρ= -0.83, p = 0.001). After completing PLIE, participants reported significant reductions in feelings of social isolation and improvements in well-being and interoceptive self-regulation. Conclusion These preliminary findings of post-PLIE improvements in DMN functional connectivity, cognition, interoceptive self-regulation, well-being and reduced feelings of social isolation warrant larger randomized, controlled trials of PLIE in older adults with SMD and MCI.
PICC versus midlines: Comparison of peripherally inserted central catheters and midline catheters with respect to incidence of thromboembolic and infectious complications.

Abstract Introduction To decrease the complications related to central catheters there has been an increasing utilization of peripherally inserted central catheters (PICC) and ultrasound-guided long peripheral intravenous catheters (i.e. midlines). While the complications of PICC lines are well described there is less reported data on complications related to midline catheters. Our study aims are to compare the incidences of infectious and deep venous thrombosis (DVT) and sepsis related to PICCs and Midlines. Methods We performed a single-center retrospective review at an academic hospital. Data were collected on patients admitted between 1/1/2014–5/31/2016. Patient demographics, hospital length of stay (LOS), and ventilator days were collected. Outcomes of interest were line-related infections and thromboembolic events after the placement of these catheters. Endpoints were compared between three groups (PICC group, midline group and PICC placement followed by midline placement group). Univariate and multivariable analyses were used to compare across the three groups. Results The study included 3560 unique patients with 5058 catheters. There was an increase in use of midlines over the observed study period (245% increase from the end of 2015 to the middle of 2016). We found no significant differences in the rates of DVT among the three groups (PICC 4%, midline 3% and PICC-midline 4%; p = 0.12). There were no differences across the groups for sepsis (PICC 29%, midline 27%, and PICC-midline 32%; p = 0.14) or septic shock (PICC 7%, midline 8%, and PICC-midline 6%; p = 0.39). Adjusted means LOS were higher for patients with PICC lines compared to midlines, in both females and males. PICC group stayed longer, on average, on the ventilator compared to the midline group. No other significant differences were seen among groups. Conclusion Increased utilization of midline catheters were not associated with decreased risk of DVT or sepsis when compared to peripherally inserted central catheters.
Enhancing Patient-Physician Experience in the Digital Era: A Review of Mobile Health Applications for Oncology Patients.

Purpose/objective(s) Telehealth, until recently, has been underutilized. With the pandemic, telehealth has quickly taken on new prominence that will likely sustain in the post-pandemic setting. Mobile health applications (apps) can be used as part of the oncologic telehealth encounter to monitor patient-reported outcomes (PROs), recorded sensor data and facilitate rapid communication. The goal of this study was to describe the characteristics of patient-centered oncology apps and associated functionalities that can improve outcomes and enhance patient-physician relationships. Materials/methods A review of apps with symptom tracking capabilities available on the iOS-based App Store and Android-based Play Store was completed in late 2020. The search terms used included: cancer, oncology, symptom tracker, radiation oncology, radiotherapy and radiation therapy. Apps were initially included if they had symptom tracking capabilities, and were further evaluated to assess patient journaling, wearable device syncing, bi-directional communication, and specificity for radiation oncology. Functionalities were tallied and compared using Microsoft Excel to examine totals and percentage distributions. Results The primary search in the app stores populated 1240 unique applications in English with 91 included in the secondary selection process after title and descriptive screening. After downloading free apps to confirm capabilities, 33 apps were eligible for the study. Of the 33 included apps, 21 (63.60%) were general symptom trackers, and 12 (36.40%) were oncology specific. None of the oncology-specific symptom tracking apps were specific for radiation oncology, but 6 (50%) of the oncology-specific apps allowed for the addition of custom symptoms. Of the 12 oncology-specific apps, 7 (58.3%) allowed for patient journaling, 3 (25%) could sync data from wearable devices, and 2 (16.7%) allowed for bi-directional communication between the patient and medical team. Of the 2 apps that included bi-directional communication, 1 (50%) app provided a chat function, and 1 (50%) app provided a video function. Comparisons of the prevalence of important functionalities between general symptom and oncology symptom trackers is shown in Table 1. Conclusion We present a comprehensive characterization of oncology-specific apps currently available. Apps focused on oncology are limited and largely unexplored. Future app development to optimize PRO collection, mobile sensor data assessment, and integration with telehealth encounters in needed. Such data can increase symptom recognition, provide timely feedback and improve quality of data collection for oncologists.
COVID-19 Risk Perceptions and Intentions to Engage in Familial Advance Care Planning: The Mediating Role of Death Anxiety.

Advance care planning (ACP) is the process of communicating about end-of-life (EOL) care with loved ones. Due to the deadly nature of COVID-19, ACP is vital. Unfortunately, fewer than 30% of American patients engage in ACP. In addition to low motivation, people experiencing death anxiety (DA) similarly avoid ACP. This finding coincides with predictions from terror management theory (TMT) that people avoid DA-arousing behaviors. Guided by the theory of planned behavior (TPB) and the health belief model (HBM), we posited COVID-19 risk perceptions would be positively associated with determinants of health behavior, including intention to share and ask loved ones about EOL wishes, as well as the associated attitudes, norms, and level of perceived behavioral control regarding ACP. Guided by TMT, we posited that DA negatively mediated relationships between COVID-19 risk perceptions and these behavioral determinants. An MTurk participant sample (N = 522) completed a survey about COVID-19 risk perceptions, DA, and health behavior determinants in the context of ACP. Results indicate COVID-19 risk perceptions were rarely directly related to these determinants. However, results of PROCESS mediation models examining the role of DA in these relationships reveal a different picture. While direct relationships were rarely significant, DA negatively mediated most relationships between COVID-19 risk perceptions and behavioral determinants. Our results indicate DA demotivates EOL communication during the COVID-19 pandemic; a concerning yet important finding due to the increased importance of ACP in the context of a deadly disease like COVID-19.
Watching back: Surveillance as activism

Preface C.Calhoun Introduction S.C.Jansen PART I: CHALLENGES 1. Media and Democracy: Some Missing Links N.Couldry 2. The Right to be Heard and the Urgency and Pleasure of Listening C.Hamelink 3. From 'the Means of Molding Opinion' to 'Media Justice': Shifts in Foundation Support for Communication Research J.Pooley 4. Public Media 2.0: Reframing Public Media for the Participatory Era J.Clark & P.Aufderheide PART II: SCHOLAR/ACTIVISTS TELL THEIR STORIES 5. Video Activism as a Way of Life D.Halleck 6. Working for International Social Justice Media: An Instructional Biography B.M.Murphy 7. Can We Be Companeros? The Media Research & Action Project C.Ryan & W.Gamson 8. Defending Dissent B.Martin PART III: COMMUNITY MEDIA 9. Detours through Youth-Driven Media: A Backseat Driver Bears Witness to the Ethical Dilemmas of Youth Media L.Taub-Pervizpour 10. !Adelante! Promoting Social Justice through Latina/o Community Media M.Castaneda 11. Community-Based Media Justice Projects in Appalachia N.Gregg PART IV: POWER STRUGGLES 12. Feminism, Media and Social Justice: Outside the Mainstream M.Gallagher 13. The Battle for the News: Project Censored and the International Media Reform Movement P.Phillips & M.Huff 14. Shooting Back: Video Activism and Reflexive Surveillance M.Andrejevic PART V: MEDIA REFORM 15. Drawing and Effacing Boundaries in Contemporary Media Democracy Work C.Dunbar-Hester 16. The Federal Communications Commission's Complicity in Excluding Minorities from the Airwaves J.Tate 17. Software Freedom as Social Justice? Open Source Software and Information Control J.L.Sullivan PART VI: PEDAGOGY 18. Designing Health Communication to Promote Social Justice S.Kahlenberg 19. Analysis and Engagement: Connecting Media Criticism to a Vision of Justice R.Andersen
Pulsed Hertzian dipole radiation and electrostatic discharge events in manufacturing

A destructive Charged Device Model electrostatic discharge event can happen in semiconductor manufacturing and should be detectable from radiation that results from collapse of an electric dipole. The analytically describable radiation field pulse of CDM can be readily produced with a new instrument that creates dipole collapse at will. A coaxial monopole E-field antenna's transfer function gives the antenna signal in near-field, and experiments compare well with theory. A major feature of the antenna response to this field pulse is a bipolar "monocycle" pulse. A transmission linebased synthetic monocycle pulser, for characterizing antenna-driven ESD detectors, can be built and is described.
Tunable chromatic dispersion compensators using MEMS Gires-Tournois interferometers

In this paper, we report on a FIR (finite impulse response) dispersion compensator made using optical MEMS (micro-electro-mechanical systems) technology. An array of micromirrors is used in a Gires-Tournois (GT) interferometer to obtain the desired dispersion value of the device. This type of device had earlier been shown to function as an optical WDM interleaver/deinterleaver. The proposed device has a periodic transfer function in the frequency domain with a well-defined free spectral range (FSR). Because of the large number of channels in dense WDM systems, periodic filters are advantageous to avoid the need for unique filters for each WDM channel.
Infantile spasms due to unilateral cerebral infarcts

Infantile spasms are an age-specific seizure disorder that occur in infants with no known underlying disorder or prior neurologic insult (cryptogenic group) as well as in infants with a variety of genetic disorders or known prior neurologic insult (symptomatic group).1-8 The presence of infantile spasms is associated with a high incidence of developmental retardation (87%)3 even in previously normal infants.3,5-7 Although there are many contradictory studies, it is generally believed that the infants in the symptomatic group, especially those with abnormal findings on neurologic examination prior to the onset of the seizures, have a significantly higher incidence of mental retardation and epilepsy than the infants in the cryptogenic group.1-9
Radiologic-Pathologic Correlation: Metastatic Pulmonary Epithelioid Hemangioendothelioma of Bone Primary

Epithelioid hemangioendothelioma is a rare vascular malignancy often characterized by a clinically indolent course and delayed diagnosis. The authors present the radiologic and pathologic features of a case of pulmonary epithelioid hemangioendothelioma which was initially thought to be calcified granulomas.
Atypical urothelial tissue fragments in noninstrumented voided urine specimens are associated with low but significantly higher rates of urothelial neoplasia than benign‐appearing urothelial tissue fragments

BACKGROUND The interpretation of urothelial tissue fragments (UTF) in voided urine (VU) specimens is controversial. If UTF contain cytomorphologically atypical cells, the diagnosis often becomes more challenging. The authors previously analyzed the outcome of patients with benign-appearing UTF in 274 noninstrumented VU specimens. In this retrospective study, noninstrumented VU specimens containing UTF with atypical cytomorphological features (AUTF) were evaluated and compared with the previous results. METHODS The Johns Hopkins Hospital electronic pathology database was searched for VU cases containing UTF over a 5-year period. RESULTS A total of 170 noninstrumented VU specimens containing AUTF were identified. Twenty-four specimens had subsequent or coincidental surgical pathology specimens with the following overall rates of neoplasia: high-grade urothelial carcinoma: 8.8% (15 specimens), low-grade urothelial neoplasia: 1.2% (2 specimens), and prostate carcinoma invading the bladder: 0.6% (1 specimen). A total of 49 specimens (28.8%) were diagnosed with urolithiasis on follow-up. Twenty-five cases had follow-up cytology specimens, all of which were negative for malignancy. Of 72 cases without histopathologic, radiologic, or cytopathologic follow-up, 62 (86.1%) had a mean clinical follow-up of 22.5 months and 10 cases did not have clinical follow-up. CONCLUSIONS The presence of AUTF in noninstrumented VU is associated with low rates of urothelial neoplasia but a statistically higher risk of urothelial neoplasia than the presence of BUTF (10.0% vs 4.4%; P<.05). In particular, the rate of high-grade urothelial carcinoma is significantly higher in noninstrumented VU specimens containing AUTF than those containing BUTF (8.8% vs 0.7%; P<.0001). In addition, urolithiasis is associated with AUTF in a substantial percentage of noninstrumented VU specimens. Cancer (Cancer Cytopathol) 2015. © 2015 American Cancer Society. Cancer (Cancer Cytopathol) 2015;123:186–192. © 2014 American Cancer Society.
LUMINESCENCE OF NITROAROMATIC MOLECULES

Abstract Mono-nitroaromatic hydrocarbons exhibit phosphorescence but do not usually fluoresce in standard glassy media at 77°K. The inverse situation (i.e., fluorescence but no phosphorescence) dominates luminescent behavior in highly acidic glassy media at 77°K. Mono-nitroaromatic hydrocarbons containing a large aromatic system exhibit both fluorescence and phosphorescence in both neutral and acid media. These peculiarities are interpreted on the basis of the induction of intramolecular charge-transfer character into the lower-energy excited states of the molecule by either protonation of the nitro group or by increasing the size of the aromatic moiety.
Electromyographic evaluation of the Myo-Monitor

D entists are frequently confronted with the problem of restoring good health to their patients’ masticatory systems by means of prosthetic devices. During the fabrication of a prosthesis, the dentist must select a mandibular position which is esthetically acceptable and an occlusal vertical dimension which does not encroach upon the closest speaking space or the interocclusal distance. This position should also be compatible with a healthy, functioning neuromuscular system. When edentulous or partially edentulous patients present the problem of mandibular positioning, “centric relation” has been used extensively as a starting point in prosthodontic therapy for the establishment of the occlusion. Attempts to establish centric relation are influenced by the patient’s ability to relax, the dentist’s ability to guide the mandible to its retruded position, and the dentist’s ability to determine when his efforts have been successful. An error in any of these three criteria can result in a mandibular orientation which may not be within the limits of that patient’s tolerance. Finally, the relationship must be compatible with the neuromuscular system of the patient. An alternate method of determining a physiologic maxillomandibular orientation, which could reduce both dentistand patient-induced errors, is desirable. The MyoMonitor+ has been suggested as a means for determining such an orientation. The Myo-Monitor is an electric stimulator which delivers a variably adjusted voltage through two mesh-plate electrodes. These adhesive-backed electrodes are positioned slightly anterior to the right and left external auditory meatuses. A third electrode is placed on the posterior midline of the neck and serves as a grounding device. It is stated in the instruction manual which accompanies the instrument that, when the unit is set to Pulse, “This circuit is programmed to deliver a stimulus of approximately 2-millisecond duration, at 1 f/2-second intervals, through each electrode. The interval provides sufficient resting time for the mandible to return completely to the rest position, between muscle contractions. With rest, the muscle can respond indefinitely, and yet not fatigue itself.
Undergraduate Business Education in the People's Republic of China

Abstract Adaptation to the Market Economy The People's Republic of China is transforming its economy to a market-driven focus. A key aspect of this is the conversion and elimination of state-owned enterprises. To do this requires a mass education program for enterprise managers. The approach to change examined in this study is based on curriculum internationalization models. This paper examines the needs perceived by potential employers for university graduates. Conclusions are based on in-depth interviews held in and around Shanghai as part of a City University of New York-Shanghai University cooperative program.
The Problem of Characterizing the 4QReworked Pentateuch Manuscripts: Bible, Rewritten Bible, or None of the Above?

This article engages the problem of whether the five manuscripts classified as 4QReworked Pentateuch (4Q158, 4Q364–367) should be considered extrabiblical compositions or simply expansive copies of the Pentateuch. Since similar methods of reworking scripture appear in both types of text, focusing on the ways scripture is reworked in the 4QRP manuscripts cannot solve the problem. Other criteria such as the literary voice, scope, and coverage of a work are more promising. The fragmentary state of the texts, however, precludes a definitive solution and requires that multiple possibilities be considered.
Partial portal decompression: Two approaches to the management of portal hypertension

To test the hypothesis that partial portal decompression in the treatment of variceal hemorrhage will diminish subsequent encephalopathy, 50 consecutive patients were studied after construction of a small-stoma (10 to 12 mm) side-to-side portacaval shunt, with the goal of a postoperative portacaval pressure gradient of 10 mm Hg. During follow-up averaging 26 months, six patients (12 percent) died. Four patients (8 percent) had episodes of rebleeding, only one from varices. All patients had patent shunts at subsequent angiography or ultrasonography. Despite consistent (100 percent) postoperative reversal or stagnation of portal flow on duplex scan, encephalopathy on clinical and psychometric grounds was observed in only three patients (6 percent). This study suggests that small-stoma portacaval shunt can be performed with reliably low rates of rebleeding and encephalopathy. That encephalopathy was rare despite loss of hepatic portal perfusion incriminates other factors besides portal flow in the genesis of postshunt hepatic failure.
Late Relapse of Type 1 Autoimmune Hepatitis After Corticosteroid Withdrawal

Relapse of autoimmune hepatitis after corticosteroid withdrawal is common, but the outer limit for this occurrence and the appropriate post-treatment surveillance strategy are uncertain. The purpose of this study was to determine the frequency and nature of relapses that occur long after drug withdrawal and to propose a long-term surveillance strategy. The intervals between drug withdrawal and relapse were determined retrospectively in 84 patients with autoimmune hepatitis. Relapses occurred in 8 patients (10%) after 49–265 months of observation (mean, 110 ± 27 months; median, 76 months), and these occurrences were separated from earlier exacerbations by at least 21 months. Treatment continued until normal liver tests and tissue had been accomplished in 14 of the 84 patients (17%), and 13 relapsed within 2–12 months. Only one of the 8 patients with late exacerbations had achieved normal liver tests and tissue immediately prior to drug withdrawal. The patients with late relapses were indistinguishable from patients with early exacerbations, and they all responded to corticosteroid-based therapy during 30 ± 10 months of observation. Autoimmune hepatitis can relapse as long as 22 years after drug withdrawal, and all late relapses responded to the resumption of corticosteroid therapy. These patients may be outliers of a typical relapse pattern or constitute a bimodal distribution of relapse that reflects different pathogenic mechanisms. The risk of relapse cannot be discounted by treatment to normal liver tests and tissue prior to drug withdrawal or protracted quiescence of the disease after termination of treatment. The unpredictable propensity for relapse warrants regular life-long surveillance.
The impact of reversal of hypoxia by revascularization on the peripheral nerve function of diabetic patients.

Hypoxia is considered to be one of the main aetiopathogenic factors of diabetic neuropathy. We have examined the effects of the reversal of hypoxia, achieved by revascularization, on peripheral nerve function in diabetic patients with or without clinical neuropathy. Fifty-six patients [mean age 62 (range 30–74) years, 44 (79%) males, 15 (27%) with insulin-dependent diabetes of 20 years (range 1–57) duration, and creatinine level 92.8±30.9 Μmol/l (mean ± SD)] were tested pre-operatively while 30 (54%) were re-examined at least 6 weeks post-operatively. At baseline the leg scheduled for operation showed worse measurements compared to the control leg when tested for Semmes-Weinstein monofilaments, peroneal motor conduction velocity (PMCV) (33.7±7.18 vs 35.7±6.09 m · s−1, p<0.05) and transcutaneous oxygen tension (37.4±24.6 vs 52.0±21.5 mm Hg, p<0.0001) while no differences were found in the vibration perception threshold and leg temperature. When baseline and post-operative measurements were later compared in the operated leg, no differences were noticed in the vibration perception threshold, PMCV and Semmes-Weinstein monofilaments but the transcutaneous oxygen tension increased significantly (32.7±27.1 vs 64.6±14.5 mm Hg, p<0.001). No differences were noticed in any of the above parameters in the contralateral leg. No correlations were found between changes in transcutaneous oxygen tension and PMCV values measured at baseline and at the follow-up visit in either leg. Similar results were found when patients were stratified according to severity of neuropathy, ischaemia and the level of the bypass. We conclude that although there is greater impairment of nerve function in the more ischaemic leg, reversal of hypoxia does not result in any significant improvement of the nerve function measurements.
USING NEWS ARTICLES TO ILLUSTRATE MATHEMATICAL MODELING CONCEPTS

ABSTRACT Current news articles are a fruitful source of ideas for mathematical applications, and, in particular, mathematical modeling. The author describes several news articles she has used in her classes. An article containing a series of economic projections is analyzed in detail and mathematical models based on statements in the article are developed by the students.
Porting the NetBeans Java 8 enhanced for loop lambda expression refactoring to eclipse

Java 8 is one of the largest upgrades to the popular language and framework in over a decade. However, the Eclipse IDE is missing several key refactorings that could help developers take advantage of new features in Java 8 more easily. In this paper, we discuss our ongoing work in porting the enhanced for loop to lambda expression refactoring from the NetBeans IDE to Eclipse. We also discuss future plans for new Java 8 refactorings not found in any current IDE.
A simple proof that every matroid is an intersection of fundamental transversal matroids

Abstract We give a new proof of a theorem of Bondy and Welsh. Our proof is simpler than previous ones in that it makes no use of Hall's theorem on the existence of a transversal of a family of sets.
Wind Tunnel Experiments of Large Particle Reentrainment-Deposition and Development of Large Particle Scaling Parameters

Reentrainment-deposition characteristics of lycopodium spores, timothy pollen, glass microballoons, glass spheres, and nickel spheres were examined in a series of wind tunnel experiments. Particle diameter varied from 18 to 34 (μm, and particle density varied from 1.0 to 8.9 g cm−3. Adhesion force distribution of each particle type was determined using the centrifuge method, and the force required to remove 50% of the particles had a range of more than an order of magnitude with lycopodium requiring the smallest force and glass spheres requiring the largest. The mean flow speed required to reentrain 50% of each particle type had a range of more than a factor of two with the same ordering from smallest speed to largest as found for adhesion force with the exception of nickel spheres, which required the second largest wind speed and the second smallest adhesion force for 50% removal. Threshold reentrainment flow speed, and distance traveled in a single reentrainment-deposition cycle were also examined for e...
The isolation of pig liver monoamine oxidase.

Abstract Monoamine oxidase from pig liver has been isolated and purified approximately three hundred-fold. This enzyme has a molecular weight of 1,200,000, is highly polymeric, and contains subunits of molecular weight 146,000, as determined by Sephadex chromatography. The apparent K m at 25°C is 1.28 × 10 −6 M at pH 9.0 (0.05 M glycine) and 1.74 × 10 −5 M at pH 7.2 (0.2 M phosphate) using benzylamine as a substrate. This enzyme contains approximately 8 copper(II) ions per 1,200,000 molecular weight.
Narrative and Research in Professional Communication

This article explores narrative theory and research in fields closely allied with professional communication to clarify the value of narrative to our discipline. It addresses the move in many fields to reconceptualize research as narrative. Placing narrative within a postmodernist frame, it examines the centrality of ethnography within a postmodernist view. The importance of ethnography in research is related to two key narrative questions that ethnographic theorists in other disciplines are addressing: Who is telling the ethnographic story? For what purposes is the story told? This article supports the importance of taking a critical stance toward these questions and discusses the implications of postmodernist ethnographic theory for research in professional communication.
Modeling the Chip-Work Contact Force for Chip Breaking in Orthogonal Machining With a Flat-Faced Tool

The present tendency towards increased automation of metal cutting operations has resulted in a need to develop a model for the chip breaking process. Conventional cutting force models do not have any provision for the study of chip breaking since they assume a continuous mode of chip formation, where the contact action of the free-end of the chip is ignored in all analyses. The new cutting force model proposed in this work incorporates the contact force developed due to the free-end of the chip touching the workpiece, and is applicable to the study of two-dimensional chip breaking in orthogonal machining. Orthogonal cutting tests were performed to obtain two-dimensional chip breaking. The experimentally measured cutting forces show a good correlation with the estimated cutting forces using the model. Results show that the forces acting on the chip vary within a chip breaking cycle and help identify the chip breaking event.
Mast cell and substance P-positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis.

Abstract Many patients with interstitial cystitis (IC) also have irritable bowel syndrome (IBS), both of which occur overwhelmingly in women, are characterized by pain and worsen under stress. Bladder and colon biopsies of a female patient with both IC and IBS were evaluated immunohistochemically. There were 40 ± 10 mast cells (MC)/mm 2 (normal, less than 10) in the bladder, which were degranulated. The colon contained 148 ± 11 MC/mm 2 (normal, less than 50), mostly close to numerous substance P (SP)-positive nerves. Histamine, methylhistamine, and the unique MC enzyme tryptase were elevated in 24-hour urine during two flare-ups. These results may help explain the concurrent presentation and the painful nature of these syndromes.
Multimodality tomographic scintimammography with PET, PECI, and SPECT: initial evaluation

We compared tomographic scintimammography performed using single photon emission computed tomography (SPECT), positron emission coincidence imaging (PECI) and positron emission tomography (PET). A female thorax phantom was used. Activities of the myocardium, thorax and breasts were adjusted to emulate the count rate observed with patients. Hollow plastic spheres, imitating hot lesions (1.5-20ml), filled with radioactive saline were inserted in the center of each breast. Specific activities of internal organs were adjusted to emulate the count rate observed with patients. SPECT data were acquired with Tc-99m using gamma cameras with NaI(Tl) detectors. A modified FBP (CODE) reconstruction algorithm was used to render SPECT tomographic images. PECI (Siemens E.CAM with NaI(Tl)) and PET (GE Advance with BGO) data were acquired using F-18 FDG. Vendor supplied reconstruction algorithms were used. The reconstructed hot lesions contrast and resolution were investigated. Image quality obtained can be ranked as follows: (1) PET(BGO), (2) PECI(NaI), (3) SPECT(NaI) In conclusion, assuming comparable uptake values of Tc-99m-sestamibi and F-18 FDG, PET seems to be a superior methodology in visualization of breast lesion as compared to SPECT and PECI. All these tomographic methods appear to be promising adjunct to x-ray mammography in difficult to interpret cases.
Unsteady and spatially variable evolution of the Neogene Andean Bermejo foreland basin, Argentina

Abstract The Miocene to Recent Bermejo retroarc foreland basin formed during development of the Andes Mountains and Sierras Pampeanas broken foreland, in west-central Argentina. Three geometrically distinct intervals existed. First, between 20 and approximately 7.3 Ma, a broad wedge-like ‘simple foreland’ basin formed adjacent to the advancing thrusts of the Western and Central Precordillera thrust belt. Second, between 7.3 and 6.5 Ma, a symmetrical foreland basin formed, while the Precordillera was likely in a subcritical state. Third, between 6.5 Ma and today, the Bermejo basin was narrow and asymmetrical, with polarity opposite to that of the simple foreland stage. The third stage accompanied both thin-skinned thrusting in the Central Precordillera and mechanical disruption of the foreland basement into small segments bounded by reverse faults of the Sierras Pampeanas. Although the 20–7.3 Ma interval can be characterized as simple foreland, there was considerable along-strike variability. The Bermejo basin was both wider and thicker in the north (29–30°S latitude) than in the south (near 31°S latitude). A northward increase in sediment supply, lateral variability in the basement, and minor along-strike variability of crustal thickening within the Precordillera thrust belt may have all contributed to the along-strike changes in the basin, but a unique cause of this difference cannot be determined with the available data. Persistent aridity was the dominant climate state throughout the 20 million year Bermejo basin history. Variability in climate is expressed in the facies, especially demonstrated by the contrast between preservation of extensive lower and middle Miocene dune deposits and their absence in strata younger than about 14 Ma, and more subtly by changes in influx of water to the basin from the high Andes catchment area.
Asking the right questions: environmental conflict in the case of Azerbaijan

This paper contributes an empirical test of key themes of the literature on natural resource conflict. Survey and interview data from an ongoing project in Azerbaijan provide insights into an unexpected lack of conflict in Azerbaijan related to the environment, resources and energy despite the predictions of resource conflict literature. We contend that questions about public perceptions about the environment and other daily concerns are critical if we are to understand who is likely (or unlikely) to be involved in conflict and why. The data presented in this paper demonstrate that Azerbaijani citizens rank environmental and resource issues among their immediate concerns and their top concerns for the country. However, compared to other day-to-day concerns such as the Nagorno-Karabakh conflict and economic concerns, environment-related concerns do not appear to be sufficient to motivate widespread violent conflict or citizen dissent related to environmental or natural resource conditions.
Association between the human thymic differentiation antigens T6 and TS

The human T lymphocyte cell surface antigen T8 has been found to be associated on thymocytes with a protein of 46 kDa through disulfide bridges. Analysis by isoelectric focusing, and of peptides obtained by limited proteolysis and chemical cleavage dem- onstrated that this 46-kDa protein was the cell surface antigen T6, which is expressed on cortical thymocytes. The findings are discussed in the context of the importance of the T8 and T6 molecules in thymic differentiation.
Electrochemical generation of free radicals in an EPR loop-gap resonator

Abstract An electrochemical cell for in situ generation of free radicals in a loop-gap resonator at X band is described. The cell is assembled from commercially available components and requires no glass blowing. The design is flexible and accommodates a variety of electrodes and electrode geometries. Remarkably small amounts of material are required. The filling factor is favorable for short-lived radicals. Performance of the cell is demonstrated by generation of the dianion radical of p -nitrobenzoic acid.
Patients on three times-weekly haemodialysis have increased mortality during the long, 2-day interdialytic interval

Commentary on: Foley RN, Gilbertson DT, Murray T, et al. Long interdialytic interval and mortality among patients receiving hemodialysis. N Engl J Med 2011;365:1099–107.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] People on long-term haemodialysis are dialysed three times-weekly such as on Mondays, Wednesdays and Fridays. Accumulation of volume and toxins over the longer 2-day interdialytic interval (eg, Friday–Monday) may provoke excess deaths. The cohort study by Foley et al asked the question whether compared with other days, morbidity and mortality is increased during the long interdialytic interval. The participants were 32 065 adults in the USA who participated in the End-Stage Renal Disease (ESRD) Clinical Performance Measures Project at the end of calendar years 2004 through 2007. Patients were excluded if they were not receiving haemodialysis three times weekly. The outcomes were various causes of morbidity and mortality and their relationship with the … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DFoley%26rft.auinit1%253DR.%2BN.%26rft.volume%253D365%26rft.issue%253D12%26rft.spage%253D1099%26rft.epage%253D1107%26rft.atitle%253DLong%2Binterdialytic%2Binterval%2Band%2Bmortality%2Bamong%2Bpatients%2Breceiving%2Bhemodialysis.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1103313%26rft_id%253Dinfo%253Apmid%252F21992122%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa1103313&link_type=DOI [3]: /lookup/external-ref?access_num=21992122&link_type=MED&atom=%2Febmed%2F17%2F5%2F161.atom [4]: /lookup/external-ref?access_num=000295081600009&link_type=ISI
Predicting aeolian sand transport rates: A reevaluation of models

Abstract Eight aeolian sand-transport models are evaluated using a field data set and a new approach to estimating shear velocity. The models are those of Bagnold, 1937 , Kawamura, 1951 , Zingg, 1953 , Owen, 1964 , Kadib, 1965 , Hsu, 1971 , Lettau and Lettau, 1978 , Sorensen, 2004 . All of these models predict transport as a function of shear velocity to the third power. Shear velocities are estimated using wind profile data (log-linear slope) with the von Karman constant and with the apparent von Karman parameter and the results of the different approaches are evaluated based on comparison of regression statistics and RMS error. The models were not adjusted to account for sediment moisture content or local surface slope effects. All of the models have about the same statistical explanatory power, so evaluations were made by comparing slopes and intercepts of best fit (least-squares) lines and RMSE. From this basis, we conclude that predictions made with the Bagnold (1937) model best match our observations, with the models of Kadib, 1965 , Hsu, 1971 performing nearly as well. The Lettau and Lettau, 1978 , Kawamura, 1951 model predictions match observations least.
Science fiction: A post-pandemic wilderness

Paul McEuen relishes the final instalment of Margaret Atwood's sweeping trilogy about a dystopian world devastated by a 'hot bioform'.
Metrazol potentiated after-discharges: dose-response relationships and effects of selective lesions.

Abstract In experiment 1 the dose-response effects of pentylenetetrazol (metrazol) on photically evoked after-discharge (PhAD) parameters were examined. Metrazol potentiated PhAD activity by affecting all measured parameters — PhAD frequency, amplitude, burst duration and spindle composition — in particular PhAD burst duration and spindle composition. A minimum effective dose of 10 mg/Kg of Metrazol was required for some statistically reliable potentiation. Metrazol dosage levels of 20 and 25 mg/Kg induced lengthy bouts of EEG spindling and spiking as well as near maximized PhAD component augmentation. In Experiment 2 stereotaxically oriented knife-cuts isolated the thalamus from cortical and/or midbrain and brainstem input. Such lesions did not block the capacity of Metrazol to potentiate PhADs, although the lesions altered evoked activity. These findings are discussed in terms of the current thought of Metrazol action and thalamic mechanisms in the control of after-discharge activity.
Performances of Micro-Tubular Solid Oxide Cell with Novel Asymmetric Porous Hydrogen Electrode

abstract Asymmetric-porous hollow-ﬁber has been fabricated by a phase-inversion process and employed as thehydrogen electrode for micro-tubular solid oxide cell (MT-SOC). The microstructure and electrochemicalproperties of MT-SOC were investigated in detail. The asymmetric-porous hydrogen electrode possessesunique two layer ﬁnger-like porous micro-structure with a thin functional layer and a thick fuel deliverylayer. When the MT-SOC was operated in fuel cell mode, maximum power densities of 0.54, 0.71 and1.25W/cm 2 wereobtainedat800,850and900 ◦ C,respectively.Ontheotherhand,whentheMT-SOCwasoperated in electrolysis mode at 900 ◦ C with an applied voltage of 1.3V, current densities of 0.68A/cm 2 and2.57A/cm 2 wereobtainedat30vol.%and80vol.%absolutehumidity(AH),respectively.Theseresultsindicatethatnovel-microstructuredMT-SOCcanbeeffectivelyfabricatedtowardshighperformancefuelcell and electrolysis cell.© 2010 Elsevier Ltd. All rights reserved. 1. IntroductionThe prospect of hydrogen economy requires the developmentof clean and efﬁcient hydrogen generation and hydrogen to elec-tricity energy conversion devices. Solid oxide cells (SOCs) havebeen considered as one of the promising technologies, since theycan be operated efﬁciently both in electrolysis mode by gener-ating hydrogen through steam electrolysis and fuel cell mode byelectrochemically combining fuel with oxidant [1–5]. For decades,many studies on SOCs have been focused on the compact designandcellperformanceenhancement.Micro-tubularsolidoxidecells(MT-SOCs)haverecentlyattractedmuchattentionfortheirgreatertolerancetothermalcycling,quickerstart-upcapability,highervol-umetricoutputdensityandportablecharacteristicscomparedwiththe conventional planar and tubular SOCs [6–9].In general, hydrogen electrode supports for MT-SOCs have beenfabricated by extrusion methods, and extensive studies have beenfocused on improving the cell performance by controlling thehydrogen electrode microstructure, for example, by adding polymethyl methacrylate (PMMA) beads, starch or graphite as poreformers [10–13]. Since Loeb and Sourirajan successfully devel-oped cellulose acetate membranes for seawater desalination in thelate 1950s, great attentions have been paid to the phase-inversionmethod to prepare asymmetric membranes widely used in ﬁber