cssi/SciSciGPT-SciSciNet huggingface dataset:
Cyst Can’t be the Case? A Unique Presentation of Multiple Tarlov Cysts (1080)

Objective: To describe a unique presentation of multiple nerve root Tarlov cysts which can mimic radicular or neuropathic processes. Background: Tarlov cysts are cerebrospinal fluid filled cysts which originate between the posterior nerve root and dorsal root ganglion. They’re often noted incidentally on imaging of the lumbosacral spine and are typically asymptomatic. Design/Methods: Case report Results: Our patient is a 60 year old female who presented with weakness and neuropathic pain in her left upper extremity. She described burning, hyperesthesia and numbness on the extensor surface of the left forearm and weakness with elbow flexion. She also described more recent development of similar sensory symptoms in the right arm without subjective weakness. Neurologic examination revealed patchy sensory loss to pinprick in C5–6 dermatomes. There was left C5–C6 myotome weakness with hyporeflexia at the biceps and brachioradialis. Electromyography (EMG) revealed evidence of active and chronic neurogenic changes in left C5–6/upper trunk innervated muscles. Evaluation of paraspinal muscles was normal. MRI of the cervical spine revealed T2 hyperintense cystic dilation of the proximal lower cervical and visualized upper thoracic nerve roots with minimal peripheral enhancement. Extension of MRI into the brachial plexus showed nonspecific mild enlargement and increased T2 signal of the brachial plexus, greatest proximally. Lumbar puncture revealed a bland CSF with normal cell count, protein and infectious studies. Genetic testing for PMP 22 was negative. Additional review of her MRI was undertaken and it was felt her imaging was consistent with multiple Tarlov/perineural cysts as opposed to an intrinsic neuropathic process. Additional MRI imaging of the thoracic and lumbar spine revealed further evidence of scattered Tarlov cysts. She had slow spontaneous improvement in left upper extremity strength and neuropathic symptoms. Conclusions: Perineural/Tarlov cysts should be a potential differential diagnosis for enlarged nerve roots and plexus’ when imaging reveals cystic thickening at the nerve root level. Disclosure: Dr. Speelziek has nothing to disclose. Dr. Stitt has nothing to disclose.
Resilience resources in low-income Black, Latino, and White fathers.

Abstract Background and aim Resilience resources are associated with positive mental and physical health outcomes. However, we know little about protective factors in low-income or racially or ethnically diverse populations of men. This study examined socioeconomic status and racial/ethnic differences in resilience resources among low-income Black, Latino, and White fathers of infants. Methods The Community Child Health Network conducted a cohort study of mothers and fathers in five sites across the U.S. A sample of fathers who identified as Black, Latino/Hispanic, or non-Hispanic White were recruited and interviewed at home on three occasions during the first year of parenting (n = 597). Several resilience resources were assessed: mastery, self-esteem, dispositional optimism, approach-oriented coping style, positive affect, social support, and spirituality. The first five resources were interrelated and scored as a composite. Results Multivariate analyses adjusted for covariates indicated that Black fathers had higher scores on the resilience resources composite compared to White and Latino fathers. Black fathers were also highest in spirituality, followed by Latino fathers who were higher than White fathers. There were significant interactions between race/ethnicity with income and education in predicting optimism, spirituality, and self-esteem. Higher education was associated with higher scores on the resilience resources composite and spirituality in Black fathers, and higher education was associated with higher self-esteem in Black and Latino fathers. Higher income was associated with higher optimism in White fathers. Conclusion These results indicate that levels of individual resilience factors are patterned by income, education, and race/ethnicity in low-income fathers, with many possible implications for research and policy.
Socioeconomic Disadvantage and Distance to Pediatric Critical Care.

OBJECTIVES To describe the geography of pediatric critical care services and the relationship between poverty and distance to these services across the United States. DESIGN Retrospective, cross-sectional study. SETTING Contiguous United States. PATIENTS Children less than 18 years as represented in the 2016 American Community Survey. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Pediatric critical care services were geographically concentrated within urban areas, with half of all PICUs located within 9.5 miles of another (interquartile range, 3.4-51.5 miles). Median distances from neighborhoods to the nearest unit increased linearly with Area Deprivation Index (p < 0.001), such that the median distance from the least privileged neighborhoods was nearly three times that of the most privileged neighborhoods (first decile = 7.8 miles [interquartile range, 3.4-15.8 miles] vs tenth decile = 22.6 miles [interquartile range, 4.2-52.5 miles]; p < 0.001). A relationship between neighborhood poverty and distance to a PICU was present across all U.S. regions and within urban/suburban and rural areas. CONCLUSIONS In the United States, the distance to pediatric critical care services increases with poverty. This carries implications for access to care and health outcome disparities.
Interobserver Agreement in the Diagnosis of Anal Dysplasia: Comparison Between Gastrointestinal and Gynaecologic Pathologists and Utility of Consensus Conferences

INTRODUCTION Management of anal dysplasia relies on the accurate diagnosis of anal biopsy specimens. As institutions move toward subspecialty signout (SSSO), decisions must be made regarding whether to assign anal biopsies to the gastrointestinal (GI) or gynaecologic (GYN) pathology service. MATERIALS AND METHODS We identified 200 archival tissue biopsies of anal mucosa and circulated them among three GI pathologists and three GYN pathologists. Each pathologist separately scored each biopsy as normal, atypical, LSIL, or HSIL. Every case that was called HSIL by at least one pathologist was stained with p16 immunostain and a "gold standard" interpretation of whether a case represented HSIL was made. RESULTS The GI pathologists agreed on 97 (49%) cases prior to consensus; the GYN pathologists agreed on 33 (17%). The sensitivities of the 3 GI pathologists in detecting HSIL against the "gold standard" were 47%, 100%, and 21%, and for the GYN pathologists the sensitivities were 74%, 89%, and 84%; the sensitivities of both the GI and GYN consensus diagnoses were 74% each. The specificities of the 3 GI pathologists in detecting HSIL were 99%, 90%, and 100%, and for the GYN pathologists the specificities were 99%, 92%, and 91%; the specificities of both the GI and GYN consensus diagnoses were 100%. CONCLUSIONS A mild to moderate degree of interobserver variability exists in the diagnosis of anal dysplasia among pathologists. Our study does indicate the utility of some form of consensus conference, as overall agreement among GI pathologists and among GYN pathologists improved following in-person consensus.
Adaptation of electronically scanned pressure measurement technology at Langley Research Center

The use of pressure-measurement devices based on electronic scanning in wind-tunnel and other settings with harsh conditions is discussed in terms of adaptations required to protect the integrity of the devices and output data. The applications considered include thermal extremes, long cable lengths, very low pressure, high-line pressure, and variable-reference calibrations. Some of the adaptation techniques are thermal enclosures, remote power supplies, low-pressure standards, and biasing regulators.
Pregnant with possibility: Reflections on embodiment, access, and inclusion in field research

Contributing to a body of theory that advocates for reflexivity and consideration of embodiment by social researchers, this article explores aspects of performing qualitative research—fieldwork and interviews—on intersections of the private family and the public state while visibly pregnant. Drawing on the author's personal experience of collecting data while pregnant, the paper shows how being pregnant facilitated access in the field, how it helped to reveal unspoken beliefs about normative and non-normative reproduction, and how pregnancy and parenthood provided a level of credibility with respondents. This article also considers the situated meanings of pregnancy in the context of academia.
Leveraging Online Learning Resources to Teach Core Research Skills to Undergraduates at a Diverse Research University.

Today’s students have unique learning needs and lack knowledge of core research skills. In this program report, we describe an online approach that we developed to teach core research skills to freshman and sophomore undergraduates. Specifically, we used two undergraduate kinesiology (KIN) courses designed to target students throughout campus (KIN1304: Public Health Issues in Physical Activity and Obesity) and specifically kinesiology majors (KIN1252: Foundations of Kinesiology). Our program was developed and validated at the 2nd largest ethnically diverse research university in the United States, thus we believe that it would be effective in a variety of student populations.
Electrostatic Interactions in Leucine Zippers: Effects on Stability and Specificity of Interaction:

Using a set of natural coiled-coil proteins as models, a series of recombinant proteins were designed and expressed in E. coli. These proteins contain a consensus coiled-coil sequence as a framework into which were incorporated positively or negatively charged residues at selected positions. A mixed-site genetic strategy was used to generate DNA fragments encoding over 4,000 different combinations of charged residues within the coiled-coil motif. A subset of these genes was used to produce recombinant coiled-coil proteins with well-defined variations in charge pattern and composition. Variants of each sequence containing a unique cysteine at the C-terminus were oxidized to the disulfide-linked dimer, and characterization of their physical properties support the proposed parallel orientation of protein chains. In all cases, equilibrium populations of dimeric and tetrameric structures were observed under physiological conditions, with dimer-to-tetramer dissociation constants in the range of 50-190 riM. Sign...
Ethics as an Imperative

INTRODUCTION While the last few years have seen disturbing ethical scandals in virtually every sector of our society, Enron and other financial scandals have raised particularly serious concerns about the ethical failure of the accounting and auditing profession. To regain the trust and respect it previously enjoyed, the profession must rebuild its reputation on its historical foundation of ethics and integrity. On that theme, the remainder of this paper focuses on ethics in the accounting and auditing profession and the role accounting academics have played and will play in the development of ethical behavior within the profession. I do not believe we have any choice about whether academics or practitioners will or will not teach ethics. Practitioners and academics assume that role when we convene a meeting as a partner in a professional services firm, or stand in front of a class of studentswhether we want to or not. Those who lead invariably teach and influenceand not just in areas related to the subject matter. Our lives and personal conduct teach far more effectively than what we say about the subject mattermore about that later.
Successful Hybrid Rescue of Occluded Pulmonary Artery in Pulmonary Atresia

Hybrid cardiac procedures are a result of synergistic cooperation between the cardiologist and surgeon. They are a combination of surgical repair and intraoperative catheter-based interventions, and may provide an effective option for the repair of complex congenital heart lesions. We present a 30-year-old man with pulmonary atresia and a ventricular septal defect. He previously had a Waterston shunt placed at 10 days of age and a right pulmonary artery shunt at 4 years of age. He had ventricular septal defect closure with a 23-mm homograft conduit connecting the right ventricular outflow tract to the main pulmonary artery confluence at 9 years of age. The patient presented to us 21 years later with pulmonary conduit obstruction, right pulmonary artery stenosis, and an occluded left pulmonary artery (LPA; Figures 1, 2A, and 2B). The catheterization demonstrated right ventricular pressure (70% of systemic arterial pressure) at 89/14 mm Hg. There was a 28-mm Hg gradient to the right pulmonary artery, and the LPA was occluded. A 7-mm distal LPA was demonstrated by left pulmonary vein wedge angiogram. Given the long occlusion between the conduit and the lower LPA, we were concerned that the LPA would not be accessible for direct patch augmentation, and hence decided to perform a hybrid procedure; …
Pigmy Marmoset as an Experimental Animal

The pigmy marmoset has been maintained under laboratory conditions for approximately (1/2) years. A synthetic diet has been prepared, which includes milk, eggs, and lard, which may cause fourfold increase in serum cholesterol levels. This species is proposed as an experimental subject for the study of aging and age-associated diseases.
The Asymptotic Structure of Transient Elastodynamic Fields at the Tip of a Stationary Crack

The asymptotic structure of the transient elastodynamic near-tip fields around a stationary crack is investigated for all three fracture modes. The transient fields are obtained as the sum of their quasi-static counterparts and corresponding transient correction terms, in terms of variable-separable expansions. By allowing the coefficients of terms in the quasi-static expansion to deviate from their quasi-static restrictions, the correction terms are shown to be the particular solutions of a set of first order (for mixed mode I and II) or second order (for mode III) ordinary differential equations with constant coefficients and non-homogeneous terms involving only sine and cosine functions of the independent variable. It is found that the transient effects of dynamic loading on the near-tip fields are to alter the universal angular variations of the quasi-static field quantities for the fifth and higher order terms in their variable-separable expansions; thus the first four terms in the expansions have the same angular variations under both quasi-static and dynamic loading conditions. This seems to suggest that transient effects on the crack-tip fields are in general less severe for a stationary crack than for a propagating crack where only the first two terms in the expansions hold the same angular variations under both steady-state and transient crack growth conditions. Furthermore, the transient higher order terms for a stationary crack do not depend on the time-rate of the stress intensity factors; in fact, they only relate to the even order time-derivatives of the instantaneous values of the coefficients of the terms in the quasi-static expansions. This is also in contrast with the case of transient crack propagation where the time rates of the dynamic stress intensity factors play important roles in the higher order transient terms. Explicit expressions for the transient near-tip stress and displacement fields are provided.
Hemoglobin changes during metamorphosis in Triturus viridescens

Abstract Hemoglobins extracted from larval, eft and adult stages of Triturus viridescens were characterized on polyacrylamide gels. Qualitative changes in hemoglobin occur during the initial but not the second metamorphosis.
Surgical strategies for anomalous origin of coronary artery from pulmonary artery in adults.

Objectives Limited data are available regarding the surgical strategies for an anomalous origin of the coronary artery from the pulmonary artery (ACAPA) in adulthood. We reviewed our surgical experience with ACAPA in adults. Methods From January 1960 to July 2011, 10 adults (30% men), aged 18 to 78 years (median, 43), underwent surgical repair of ACAPA. Anomalous left (ALCAPA) was present in 7, anomalous right (ARCAPA) in 2, and anomalous left anterior descending artery in 1. Most (90%) were symptomatic, with 7 (70%) having ischemic changes on a preoperative at rest or stress electrocardiogram. One patient had undergone previous ligation of ALCAPA in childhood. The mean left ventricular ejection fraction was 56% ± 10%, with mild dysfunction in 4. Results Of the 10 patients, 7 underwent repair by coronary artery button transfer to the aorta, with 2 requiring an interposition saphenous vein graft. In 3 patients, coronary transfer was not possible, and coronary artery bypass grafting with closure of the ACAPA was performed. The mean follow-up was 8.6 years (maximum, 37). Two late deaths occurred from noncardiac causes. One patient with ALCAPA who underwent direct reimplantation subsequently required coronary artery bypass grafting for left main stenosis, likely secondary to tension. At the last follow-up visit, all patients were in New York Heart Association class I or II. The postoperative left ventricular ejection fraction was similar at 53% ± 9%; No significant improvement was seen in those with below normal ejection fraction. Conclusions Establishment of a dual coronary artery system with coronary transfer is preferred, even if an interposition graft is required. Coronary artery bypass grafting with closure of ACAPA should be reserved for when coronary transfer is not feasible. Surgical correction of ACAPA should be considered before the onset of left ventricular dysfunction.
Some structure-bonding correlations in reduced ternary molybdenum oxides with infinite chains of edge-shared octahedral cluster units

Abstract The work reported here is concerned with the structure-bonding relationships among compounds belonging to the structure types NaMo 4 O 6 , Sc 0.75 Zn 1.25 Mo 4 O 7 , Mn 1.5 Mo 8 O 11 , Ca 5.45 Mo 18 O 32 and LiMo 8 O 10 . Each of these structures is dominated by MoMo bonding in infinite chains composed of edge-shared octahedral cluster repeat units. It is shown that the application of both MoO and MoMo bond distance-bond order equations can provide useful information about the bonding in these chains. In both simple and complex structures reasonable estimates have been obtained for valence of Mo atoms, net charges on cluster anion repeat units, and numbers of electrons actually involved in the MoMo bonding.
Neurofluctuation in patients with subcortical ischemic stroke

Objective: The purpose of this study was to assess the incidence of deterioration, fluctuation, and associated risk of poor outcome in patients with subcortical stroke (SCS). Methods: We conducted a prospective observational study, enrolling patients admitted with SCS based on their clinical examination and imaging studies. An NIH Stroke Scale evaluation was performed daily and whenever deterioration in examination was detected. Neurologic deterioration was defined as a motor score increase of at least 1 on the NIH Stroke Scale. Modified Rankin Scale scores at discharge were used to assess outcome. Results: Among 90 enrolled patients, 37 (41%) deteriorated, 75% of them in the first 24 hours after enrollment. Administration of tissue plasminogen activator was significantly associated with deterioration (hazard ratio 2.25; 95% confidence interval [CI]: 1.13–4.49) even after controlling for the association of deterioration with the early poststroke period. Deterioration conferred an increased risk of poor outcome (modified Rankin Scale scores 3–6) at discharge (relative risk: 1.80; 95% CI: 1.71–1.93). Reversion back to predeterioration deficits occurred in 38% of patients, and was associated with reduced risk of poor outcome at discharge (relative risk: 0.12; 95% CI: 0.02–0.83). Treatment with tissue plasminogen activator conferred better chances of spontaneous recovery to predeterioration deficits after initial deterioration (hazard ratio: 4.36; 95% CI: 1.36–14.01). Conclusion: More than 40% of patients with SCS deteriorate neurologically. Deterioration tends to occur early after stroke, spontaneously reverses in approximately one-third of cases, and poses an increased risk of poor outcome. Therapies are needed to prevent, arrest, or reverse deterioration in patients with SCS.
“Religion” as the Cipher for Identity: The Cases of Emperor Julian, Libanius, and Gregory Nazianzus

In this paper I shall explore how religion functioned as a signifier of identity for Emperor Julian, his friend and teacher, Libanius, and his jealous enemy, Gregory Nazianzus, during the bewildering period of Julian's short reign and sudden death. However, before discussing each man's case, it will be useful to clarify the conceptual boundaries of the discussion. Because the term “religion,” as used in the academic world, is problematic for analyzing fourth-century culture, it is first necessary to isolate the concept of religion from the process of universalization. Drawing on the analyses of several post-colonialist theorists, I shall show why the term requires this disengagement, and why its meaning is best understood in light of the complications of specific historical circumstances. Once this issue has been broached, I shall introduce a theoretical basis for viewing “culture” as a commodity that was used by Christianity and pagan religions from 314–365, when, for the most part, both sides enjoyed a rest from institutional persecution. shall also discuss how the concepts of religion and learning were brokered as cultural commodities by these same social groups. Having established this theoretical framework as the basis of my analysis, I shall turn to the investigation of what religion is for Julian, Libanius, and Gregory Nazianzus, how it fits into their own self-image, and what role each envisions for religion as corporate identity for civilized people of the oikoumene.
Geometric modeling using focal surfaces

The differential geometry of smooth three-dimensional surfaces can be interpreted from one of two perspectives: in terms of oriented frames located on the surface, or in terms of a pair of associated focal surfaces. These focal surfaces are swept by the loci of the principal curvatures' radii. The normal of each focal surface indicates a principal direction at the corresponding point on the original surface [Pottmann and Wallner 2001]. In this article, we utilize piecewise linear focal surfaces, which we call focal meshes, to model smooth surfaces.
Effect of projectile energy, specimen temperature and fast thermal diffusing atoms on ion beam mixing

Ion beam mixing of Au markers in Cu samples was measured after 500-keV Kr irradiation at 6, 80, and 295 K. Additional measurements were performed on samples irradiated at 80 K with 1.8-MeV Kr and 295 K with 1.7-MeV Kr. It was observed that the mixing is the same at 6 K as at 80 K but that it is somewhat greater at 295 K. It was also found that at both 80 and 295 K the mixing is the same for 500-keV as for 1.7 MeV projectile energies if the irradiations are compared on the basis of deposited damage energy. Another set of mixing measurements were performed on Ni and Ti markers in Hf and Hf markers in Ni at 6, 80, and 295 K. Although Ni is known to be a fast thermal diffusing atom in Hf, only a 50% difference in ion beam mixing was observed for the Ni and Ti markers at 6 or 80 K. For these marker systems, the mixing was also approximately the same at 6 and 80 K. At 295 K, the mixing remained constant for the Ti marker, increased slightly for the Hf marker in Ni, but decreased strongly for the Ni marker in Hf. The results for both sets of measurements are interpreted according to a qualitative picture of the development of displacement cascades obtained from molecular dynamics computer simulations.
High contrast metastructures for light manipulation

A completely new class of planar optics has emerged using subwavelength metastructures with a large index contrast. Uniform and chirped gratings can be used to create high reflection mirrors, high-Q resonators with surface-normal output, hollow core waveguide, vertical to in-plane waveguide coupler, and focusing reflectors and lenses.
What is the radiation exposure to patients during a gynecoradiologic procedure

Objective To evaluate the risk of radiation exposure to infertility patients during a gynecoradiologic procedure. Design Retrospective clinical study. Setting Medical school-affiliated infertility center. Patient(s) Three hundred thirty-two consecutive infertility patients undergoing a gynecoradiologic procedure. Intervention(s) Patients underwent a gynecoradiologic procedure as part of their infertility workup and the fluoroscopic exposure time was analyzed. Main Outcome Measure(s) The fluoroscopic exposure (rad time) during gynecoradiologic procedures, including hysterosalpingogram (HSG), selective salpingography, tubal catheterization, and others. Result(s) The rad time (mean ± SD) was 63 ± 54 seconds for normal HSG (n = 94, range 17 to 404 seconds), 100 ± 61 seconds for abnormal HSG (n = 53, range 28 to 272 seconds), 11.1 ± 57 seconds for unilateral selective salpingography (n = 36, range 31 to 324 seconds), 142 ± 74 seconds for bilateral selective salpingography (n = 87, range 40 to 430 seconds), 176 ± 77 seconds for unilateral tubal catheterization (n = 27, range 70 to 342 seconds), and 239 ± 82 seconds for bilateral tubal catheterization (n = 30, range 110 to 381 seconds). Five patients had other procedures, such as lysis of intrauterine adhesions (n = 2) and resection of an uterine septum (n = 3), for which the rad time was in a range of 180 to 300 seconds. Conclusion(s) The radiation exposure of patients during a gynecoradiologic procedure, using previously described standard techniques, is well within established margins of safety. Fertil Steril® 1997;67:401-3
Clinical and morphometric results of penetrating keratoplasty with one-piece anterior-chamber or suture-fixated posterior-chamber lenses in the absence of lens capsule.

• The clinical records and serial corneal endothelial images of 25 acapsular, pseudophakic eyes with Kelman-style, one-piece, anterior-chamber intraocular lenses and 24 acapsular, pseudophakic eyes with suture-fixated, posterior-chamber intraocular lenses following penetrating keratoplasty were reviewed to determine clinical success and endothelial survival after 1 year. Twenty-two (88%) of 25 grafts in the anterior-chamber intraocular lens group and 23 (96%) of 24 grafts in the sutured posterior-chamber intraocular lens group were clear after 1 year; best corrected visual acuity of 20/40 or better was noted in 25% of the eyes in the anterior-chamber intraocular lens group and 29% of the eyes in the sutured posterior-chamber intraocular lens group. The mean intraocular pressure for the anterior-chamber intraocular lens group was significantly lower than for the sutured posterior-chamber intraocular lens group at 3 months (17 ± 4 vs 21 ± 7 mm Hg) and at 6 months (17 ± 3 vs 20 ± 5 mm Hg), but did not differ at 1 year. The mean percent of endothelial cell loss after 1 year did not differ between the anterior-chamber intraocular lens group (32% ± 26%) and the sutured posteriorchamber intraocular lens group (27% ± 26%). No clinical or endothelial morphometric advantages were noted after 1 year for the suture-fixated, posterior-chamber intraocular lens over the Kelman-style, one-piece anterior chamber, intraocular lens following pseudophakic penetrating keratoplasty; however, a long-term, prospective, randomized study of these two intraocular lens types is recommended.
A low-cost method for digitizing videotaped continuous movements on the Macintosh

We describe an inexpensive means of digitizing videotaped positions of moving points, such as the positions of the joints of a person who is performing an action. Single-frame video images and a Macintosh computer monitor are optically superimposed, using a half-silvered mirror, and the positions of reference points in the video image are manually clicked in by the operator, so that the screen coordinates of the reference points on each frame can be stored in a text file for later analysis. The digitizing program records comments and identifying information along with the position data.
Some essential differences between consciousness and attention, perception, and working memory

When "divided attention" methods were discovered in the 1950s their implications for conscious experience were not widely appreciated. Yet when people process competing streams of sensory input they show both selective processes and clear contrasts between conscious and unconscious events. This paper suggests that the term "attention" may be best applied to the selection and maintenance of conscious contents and distinguished from consciousness itself. This is consistent with common usage. The operational criteria for selective attention, defined in this way, are entirely different from those used to assess consciousness. To illustrate the scientific usefulness of the distinction it is applied to Posner's (1994) brain model of visual attention. It seems that features that are often attributed to attention-like limited capacity-may more accurately be viewed as properties of consciousness.
Stimulation of enzymatic activity in filament preparations of casein kinase II by polylysine, melittin, and spermine

Casein kinase II (CKII) has been purified from bovine heart tissue. Under conditions of low salt (0.05 M NaCl, 10 MM MgCl2), CKII forms structured aggregates that appear as filaments similar to results obtained withDrosophila CKII [C.V.C. Glover (1986) J. Biol. Chem. 261:14349]. The aggregates have been analyzed by sucrose density gradients and electron microscopy. Filament preparations of the enzyme have reduced but measurable kinase activity. The addition of salt restores activity. Various modulators of CKII activity have been examined with the enzyme in the low salt, polymerized form. The polyamines spermine or spermidine stimulated CKII activity as much as six fold; putrescine had no effect. Polylysine of varying lengths activated CKII 4–6 fold. Melittin, the basic polypeptide from bee venom, was also an effective activator. Activation of filament preparations was also observed if the CKII specific peptide (RRREEETEEE) was used as the substrate in place of casein. These results with filament preparations provide an alternative in vitro system for the study of possible regulatory aspects of CKII.
Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats

Rationale Acetylcholine (ACh) is involved in brain reward and learning functions and contributes to opiate- and psychostimulant-motivated behaviors. Tacrine is a centrally acting, reversible cholinesterase inhibitor that also inhibits monoamine oxidase (MAO) and blocks reuptake of dopamine (DA) and serotonin.
Delayed hypersensitivity to mumps antigen in humans

Sixty-one subjects, preselected for mumps sensitivity, were entered into a double-blind protocol to standardize Mumps Skin Test Antigen. Four lots of mumps antigen selected on the basis of in vitro potency tests were used. Four other antigens, Histoplasmin, Dermatophytin-O, Dermatophytin, and fluid tetanus toxoid were also tested; positive reactions for these four antigens occurred in 48, 68, 25, and 43% of individuals, respectively. The mumps lots exhibited delayed hypersensitivity with positivity ranging from 63 to 67% at 20 CFU/ml and 77 to 84% at 80 CFU/ml in the acceptable lots. Side effects were primarily local and minor in nature. Mumps Skin Test Antigen is a useful measure of the integrity of the immune system, but lacks complete specificity because of local dermal factors.
THE PREPARATION AND SURFACE CHARACTERIZATION OF AN IDEAL MODEL COLLOID

ABSTRACT Monodisperse polystyrene latexes were prepared with and without emulsifier using persulfate initiator. The latexes were ion-exchanged with purified Dowex 50W(H+)-Dowex 1(0H−) mixed resin to remove solute electrolyte and adsorbed emulsifier and to convert acidic surface groups to the H+ form. Conductometric titration showed that all latexes contained only strong-acid surface groups, presumably the sulfate endgroups of the polymer chains introduced by the persulfate initiator. The sulfate-stabilized latexes (H+ form) were hydrolyzed to the hydroxyl form after 2–8 weeks at room temperature or 48–120 hours at 363°K. The rate of the acid-catalyzed hydrolysis is enhanced by increasing the glass contact surface area, by adding Pyrex glass beads. Conductometric titration of the hydrolyzed latexes after ion exchange showed no titratable groups, indicating that the latexes were stabilized by hydroxyl groups. The latexes were oxidized to the carboxyl form by heating the hydroxyl-stabilized latex with persul...
Authenticated, private, and secured smart cards (APS-SC)

From historical perspective, the recent advancements in better antenna designs, low power circuitry integrations and inexpensive fabrication materials have made possible a miniature counter-measure against Radar, a clutter behaving like a fake target return called Digital Reflection Frequency Modulation (DRFM). Such a military counter-measure have found its way in the commerce as a near field communication known as Radio Frequency Identification (RFID), a passive or active item tag T attached to every readable-writable Smart Card (SC) : Passports ID, medical patient ID, biometric ID, driver licenses, book ID, library ID, etc. These avalanche phenomena may be due to the 3 rd Gen phones seeking much more versatile & inexpensive interfaces, than the line-of-sight bar-code optical scan. Despite of the popularity of RFID, the lacking of Authenticity, Privacy and Security (APS) protection restricted somewhat the wide spread commercial, financial, medical, legal, and militarily applications. Conventional APS approach can obfuscate a private passkey K of SC with the tag number T or the reader number R , or both, i.e. only T*K or R*K or both will appear on them, where * denotes an invertible operation, e.g. EXOR , but not limited to it. Then, only the authentic owner, knowing all, can inverse the operation, e.g. EXOR*EXOR = I to find K . However, such an encryption could be easily compromised by a hacker seeking exhaustively by comparison based on those frequently used words. Nevertheless, knowing biological wetware lesson for power of pairs sensors and Radar hardware counter-measure history, we can counter the counter-measure DRFM, instead using one RFID tag per SD, we follow the Nature adopting two ears/tags, e.g. each one holding portions of the ID or simply two different ID's readable only by different modes of the interrogating reader, followed by brain central processor in terms of nonlinear invertible shufflers mixing two ID bits. We prefer to adopt such a hardware-software combined hybrid approach because of a too limited phase space of a single RFID for any meaningful encryption approach. Furthermore, a useful biological lesson is not to put all eggs in one basket, "if you don't get it all, you can't hack it" . According to the Radar physics, we can choose the amplitude, the frequency, the phase, the polarization, and two radiation energy supply principles, the capacitance coupling (~6m) and the inductance coupling (<1m), to code the pair of tags differently. A casual skimmer equipped with single-mode reader can not read all. We consider near-field and mid-field applications each in this paper. The near-field is at check-out counters or the convey-belt inventory involving sensitive and invariant data. The mid-field search & rescue involves not only item/person identification, but also the geo-location. If more RF power becomes cheaper & portable for longer propagation distance in the near future, then a triangulation with pair of secured readers, located at known geo-locations, could interrogate and identify items/persons and their locations in a GPS-blind environment.
The limiting absorption principle and spectral theory for steady-state wave propagation in globally perturbed nonselfadjoint media☆

A fundamental problem in classical physics is to describe the waves produced in a medium by the action of prescribed sources. When such sources have a sinusoidal time dependence (as is frequently postulated), the resulting waves may be expected to have the same oscillatory behavior in time, apart from a transient wave. The problem of determining this steadystate response is usually called the steady-state wave propagation problem. This paper deals with the steady-state propagation problem for electromagnetic waves in a class of globally perturbed nonselfadjoint media. Here, we shall consider the problem in a certain subspace of inhomogeneous data. Systems other than Maxwell’s equations may be treated using the methods of this paper and such will be the subject of future work. Up to this point integral (global) perturbations of Maxwell’s equations have received little consideration, to our knowledge. Our problem is a special case of the more general problem
Educating Pharmacists on Ophthalmic- and Otic-Drop Administration Techniques Using Internet-Based Video Clips

In 2003, 3.22 billion prescriptions were dispensed in U.S. community pharmacies, including more than 39 million prescriptions dispensed for 19 different ophthalmic and otic drops.1 Patients must use ophthalmic and otic medications correctly to achieve optimal outcomes. One factor in ensuring proper use is provison of patient counseling. Pharmacists need to know how to administer drops correctly so that they can teach these skills to their patients. We developed Internet-based multimedia video clips to teach ophthalmic and otic drop administration techniques. These video clips have been shown to be useful in teaching student pharmacists the correct techniques.2 In doing so, our focus was to demonstrate how an Internet-based multimedia video clip could efficiently augment the knowledge base of pharmacists, providing an opportunity to improve their ability to counsel patients on the administration of ophthalmic and otic products. The 3.22 billion prescriptions dispensed in 2003 represents a significant increase from the 2.8 billion prescriptions dispensed 1999, and a 47% projected increase to 4.5 billion prescriptions is expected by 2010.3,4 In 2003, an estimated 132,289 community pharmacists were in practice (24,341 prescriptions per pharmacist), and the number of community pharmacists is expected to rise only 9.2% to 144,508 by 2010.4 In view of the current pharmacist shortage and the projected increase in prescription volume in the coming years, pharmacists face increased time constraints for patient counseling over what they currently experience. Efficient patient counseling will become even more important than it is now. Objectives
A volumetric 3D model of the human jaw

Abstract The purpose of this paper is to introduce a detailed approach for constructing a complete model of the human jaw. Our previous work developed an accurate model of the human jaw surface. Unfortunately this surface is not enough for the analysis purpose which requires a detailed model of the teeth and their roots. A database of volumetric 3D models of teeth is constructed from the CT scans. The crown the tooth coming from the shape modeling algorithm provided in our previous work is matched with one of the database teeth. A registration technique is used to deform the matched tooth with our previous derived surface model. Combining this information with the jaw details and X-ray information of the roots, we can now derive a complete volumetric 3D model of the human jaw. This model is suitable for the analysis process which will include finite element work to analyze the stress and strain for different simulations. The simulations processes will include, among others, tooth-implanting and alignment.
A mean field approach to competition in large scale wireless systems

We study competition between wireless devices in a dynamic setting. We model such systems as non-cooperative stochastic games. Computing the equilibrium behavior of devices in stochastic games is computationally prohibitive, especially when the number of devices are large. To deal with the complexity of such large scale systems, we use an approximate solution concept called the oblivious equilibrium, (proposed by Weintraub et. al) where each device reacts to the aggregate state of other devices. We show that under some structural assumptions on the model primitives of the game, the oblivious equilibrium approximates the actual Markov perfect equilibrium. This allows us to use compute the equilibrium behavior of these devices in large scale games.
Abstract 4864: Aroma terpenes prevent UVB-induced sunburn in Skh1 mouse skin.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Understanding how aroma terpenes prevent sunburn and/or skin cancer in mice could lead to more effective and safer ways of blocking sun damage to human skin. In our previous study, β-damascenone, an aroma terpene, protected against sunburn by activating both keratinocyte and sebaceous gland pathways that fortified and thickened the cornified envelope and sebum layers of mouse epidermis. In the current study, the sunburn preventive activity of d-limonene was examined to confirm that these related compounds work similarly. In addition to sunburn, immunohistochemical analyses of proliferation (PCNA) and a damage-response gene N-Myc Down Regulated Gene 1 (NDRG1) were investigated in control versus d-limonene-treated Skh-1 mice. The mice were treated either topically on the dorsum or orally with different concentrations of d-limonene in liponate (100%, 10%, 1% and 0%) followed by exposure of the dorsum to solar simulation ultraviolet radiation (UVR) of 1.5 kJ/m2 from fluorescent ‘sunlamps’. Either 4 topical 5 μL doses or a single dose of 20 μL (0.95 μg/g body weight) of 100% d-limonene provided complete protection from UVR-induced sunburn. The protection was less but still significant at 10% d-limonene but was absent at 1% d-limonene in comparison to UVR alone. PCNA-labeling showed a marked proliferation increase of epidermal basal cells, outer root sheath cells of hair follicles and sebaceous gland cells by separate exposures to d-limonene and UVR relative to controls. The combined treatment of d-limonene followed by UVR produced fewer PCNA-positive cells in epithelial tissue relative to UVR-only mice. The NDRG1 protein (an indirect measure of DNA damage) was overwhelmingly (∼85% of keratinocytes) induced by UVR indicating heavy DNA damage. The UVR-induced NDRG1 index remained at ∼85% at 1% d -limonene, but was significantly reduced at 10% d-limonene to ∼24% and to less than 1% at 100% d -limonene indicating nearly complete elimination of cellular damage as a pure compound; a finding that is consistent with complete sunburn prevention. The thickness of the cornified envelope plus sebum layers nearly doubled within 5 days after administration of the d-limonene corresponding to the time of UVR application. Overall the results indicate that d-limonene protected against sunburn by activating keratinocyte/sebaceous gland-based pathways that fortified and thickened the cornified envelope plus sebum layers on the skin surface by releasing elevated levels of UVR-absorbing proteins that decreased UVR dose to underlying cutaneous tissues. Citation Format: Ahmed N. Uddin, Ivica Labuda, Feng Wu, KamMeng Tchou-Wong, Fredric J. Burns. Aroma terpenes prevent UVB-induced sunburn in Skh1 mouse skin. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4864. doi:10.1158/1538-7445.AM2013-4864
Deporting social capital: Implications for immigrant communities in the United States

The United States currently removes approximately 400,000 individual migrants each year, which represents close to an eightfold increase since the mid-1990s. While scholars have studied the consequences of such policies for children and families, this article posits broader effects on communities through the reduction of immigrant social and human capital. Using findings from three studies of immigrant communities and Salvadoran deportees, we show that current deportation practices remove individuals with a wide range of socio-economic resources and ties to local communities. When they are removed from economic, family, social, and civic networks, the individuals and communities left behind are impoverished in important ways. This is particularly consequential for low-resource immigrant communities, which under the best of circumstances encounter obstacles to economic advancement, social integration, and political engagement. In addition, we consider the potential harm to the institutions in which immigrants participate, such as businesses and churches, which has implications for the economy and society more generally.
Effects of a despaced secondary of a Wolter type II telescope on image quality

The focal shift of the Wolter type II telescope, a glancing incidence analog of the normal incidence Cassegrain telescope, due to the despacing of the secondary with respect to the primary, is analyzed. The location of the rms best focus on the optical axis can be derived from a resulting expression. The results are verified by ray tracing of an actual Wolter type II telescope.
A Comparison of Metal-Loaded DOW3N Ion Exchangers for Removal of Perchlorate from Water

Abstract In this work, an alternative class of perchlorate selective ion exchangers (known as polymeric ligand exchangers, PLEs) were prepared by loading six transition metals (Cu(II), Co(II), Zn(II), Ni(II), Fe(II), and Fe(III)) onto a commercially available chelating resin Dowex M4195 (DOW3N). The resultant PLEs (DOW3N-Me, where Me = one of the metals) were tested with respect to their perchlorate selectivity, capacity, kinetics, and regeneration efficiency through a series of batch and column experiments. Within this group of PLEs, DOW3N-Cu(II) showed the highest perchlorate capacity; all four PLEs had similar perchlorate sorption kinetics; and DOW3N-Fe(III) demonstrated better regeneration potential.
Card random access memory (CRAM): functions & use

The National Cash Register Company's Card Random Access Memory (CRAM) is a unique device which provides for the first time a single practical unit for both random and sequential processing. This flexibility, when applied to the actual requirements of data processing installations, permits the use of powerful techniques resulting in highly efficient operations. In order to understand how this is achieved it will be necessary to have a knowledge of the basic CRAM mechanism and of the relationship of the CRAM to the NCR C-315 Data Processing System (Section A). Use of the CRAM in general application areas will then be discussed (Section B), and finally a brief description will be given of the programming packages developed for CRAM (Section C).
A brief review of physical initialization

This review presents a short summary of studies on physical initialization carried out at Florida State University. This summarizes the findings in several areas such as: the formulation of physical initialization, impact (and skill) on the nowcasting and short range prediction of rainfall, medium range prediction of typhoons, mesoscale structures implied by physical initialization, impact on the spread of an ensemble of typhoon forecasts and the improvements of hydrological budget during flooding events. References are provided in each section where further details for each of these areas are presented.