cssi/SciSciGPT-SciSciNet huggingface dataset:
The Influence of Music on Facial Emotion Recognition in Children with Autism Spectrum Disorder and Neurotypical Children

Background Children with autism spectrum disorder (ASD) often struggle with social skills, including the ability to perceive emotions based on facial expressions. Research evidence suggests that many individuals with ASD can perceive emotion in music. Examining whether music can be used to enhance recognition of facial emotion by children with ASD would inform development of music therapy interventions. Objective The purpose of this study was to investigate the influence of music with a strong emotional valance (happy; sad) on children with ASD's ability to label emotions depicted in facial photographs, and their response time. Methods Thirty neurotypical children and 20 children with high-functioning ASD rated expressions of happy, neutral, and sad in 30 photographs under two music listening conditions (sad music; happy music). During each music listening condition, participants rated the 30 images using a 7-point scale that ranged from very sad to very happy. Response time data were also collected across both conditions. Results A significant two-way interaction revealed that participants' ratings of happy and neutral faces were unaffected by music conditions, but sad faces were perceived to be sadder with sad music than with happy music. Across both conditions, neurotypical children rated the happy faces as happier and the sad faces as sadder than did participants with ASD. Response times of the neurotypical children were consistently shorter than response times of the children with ASD; both groups took longer to rate sad faces than happy faces. Response times of neurotypical children were generally unaffected by the valence of the music condition; however, children with ASD took longer to respond when listening to sad music. Conclusions Music appears to affect perceptions of emotion in children with ASD, and perceptions of sad facial expressions seem to be more affected by emotionally congruent background music than are perceptions of happy or neutral faces.
A Pathobiological Role of the Insulin Receptor in Chronic Lymphocytic Leukemia.

Abstract 2324 Poster Board II-301 The presence of genomic aberrations in CLL, including del17p and del11q, affects CLL patient survival, and thus an in-depth understanding of the genes influenced through these deletions is important. Further, genes affecting CLL disease progression that is observed in patients with recurrent genomic deletions, including del11q, remain incompletely characterized. Focusing therefore on del11q in CLL, we employed comparative expression array profiling (Affymetrix 133 2.0 plus arrays) of RNA from sorted CD19+ cells from 10 cases with and nine cases without del11q to identify stable transcriptome differences associated with del11q. Through these efforts we have identified for the first time differential expression of the insulin receptor (INSR) in CLL and predominant INSR expression in CLL with del11q. We have validated this finding in a cohort of 219 CLL cases. Our aggregate data suggest biologically and clinically meaningful INSR expression in a substantial subset of all CLL cases. INSR stimulation by insulin in CLL cells expressing the INSR resulted in the activation of canonical INSR signaling pathways, including the AKT-mTOR and Ras/Raf/Erk pathways, and INSR activation partially abrogated CLL cell apoptosis ex vivo . Clinically, CLL cases with INSR expression displayed larger lymphnodes and higher Rai stage at study enrollment and the disease progressed faster requiring repeat therapy earlier than CLL cases with low or absent INSR expression. This novel data provides the first description of a pathobiological role of the insulin receptor in CLL biology and disease progression, thus identifying a potential mediator and mechanism for del11q-associated CLL phenotypes. The identification of a transmembrane tyrosine kinase receptor with direct effects on CLL biology and clinical behavior offers opportunities for CLL prognostication and targeted therapy development and further strengthens the case for involvement of the INSR in cancer biology. Disclosures: Malek: Cephalon: Honoraria, Speakers Bureau; Celgene: Honoraria, Speakers Bureau; Affymetrix: Research Funding. Erba: Lilly: Research Funding; Antisoma: Research Funding; Wyeth: Research Funding; Cephalon: Honoraria, Research Funding; MGI Pharma: Honoraria; Pharmion: Honoraria; Celgene: Honoraria; BMS: Honoraria; Novartis: Honoraria, Research Funding; Genzyme: Consultancy, Honoraria, Research Funding; Gemin-X: Research Funding; Kanisa: Research Funding.
Gastrointestinal Complications in Shock

Organs of the gut become ischemic during shock. This ischemia produces injuries resulting in cell death within these organs and the release of toxic mediators, which accelerates circulatory failure. Collaborative care of the shock patient should include measures to improve perfusion to maximize individual organ integrity and to increase the chance of long-term survival from shock.
Visit to Campus

Tim, a lanky student in my spring “Latin American Cultures” class, wrote something so beautiful that I had to do something about it. In response to my request on the first day of class for a description of something interesting that the students had recently learned, this is what Tim wrote about the monarch butterfly’s migration every year from central Mexico to the United States and back again: It has been proven time and time again that each generation of monarch butterfly, when migrating in the cold season, returns to the exact same spots, the exact locations that their ancestors travelled to, down to the exact trees. Genetic testing and alterations of the trees themselves have no effect on these simple beautiful fluttering wonders.
Overtures for the Triumph of the Tweet: White Power Music and the Alt-Right in 2016

The role of music in contemporary culture and politics as a tool for mobilizing popular resistance against states, corporations, and other political movements is brought expertly into focus by Nanc...
Rivalry between Basic and Applied Research in Public Research Labs

The purpose of this paper is to investigate the rivalry between basic and applied research within public research labs. Study design considers the international publications a proxy of basic research, whereas the self-financing deriving from technology transfer activities is an indicator of applied research. A case study based on Italian National Research Council, one of the biggest European research bodies shows an interesting organizational behavior of research labs. The results reveal an increasing rivalry between basic and applied research due to shrinking of public research lab budgets. Institutes and researchers pay more attention to applied research, which is capable of attracting new funds from the market necessary to the economic survival of public research institutes but this approach reduces basic research with alarming effects for production of science in the long run. R&D management implications are discussed.
Data Management, Sharing, and Dissemination at Drills and Spills

ABSTRACT # 2017-234 The California Department of Fish and Wildlife, Office of Spill Prevention and Response (OSPR) has drafted a “Data Management and Sharing Plan” document for use in drills and oi...
TBI Rehabilomics Research: an Exemplar of a Biomarker-Based Approach to Precision Care for Populations with Disability.

The purpose of this review is to summarize how “-omics” technologies can inform rehabilitation-relevant outcomes for a range of populations with neurologically related disability by including outcome metrics linked to the World Health Organization’s International Classification of Functioning, Disability, and Health (WHO-ICF) domains of impairments in body function, activity limitations, and participation restrictions. To date, nearly every area of medicine uses biomarkers in some capacity to aid in understanding how personal biology informs clinical care. “-Omics”-based approaches use high throughput genomics, proteomics, and transcriptomics assay platforms to tailor and personalize treatments for subgroups of similar individuals based on these results. The recent Precision Medicine Initiative (PMI), sponsored by the National Institutes of Health (NIH), has propelled biomarker-based and genomics research to the forefront of many translational research and care programs addressing a variety of medical populations. Yet, the literature is sparse on precision medicine approaches for those with neurologically related and other disability. We demonstrate how the Rehabilomics Research model represents a translational framework for programs of precision rehabilitation research and care focused on linking personal biology to the biopsychosocial constructs that represent the WHO-ICF model and multidimensional outcome. We provide multiple exemplars from our own research program involving individuals with moderate-to-severe traumatic brain injury (TBI) to demonstrate how genomics and other biomarkers can be identified and assessed for their capacity to assist with personalized (precision) neurorehabilitation care and management.
Is There a Path from Sin City to Tech City? The Case for Las Vegas

Many cities aspire to have vibrant entrepreneurial ecosystems that are relevant to the digital economy—can they? To answer the question, we examine the economic history of Las Vegas, a land of gambling and entertainment, and report the recent entrepreneurial activities in the city along with the data that measures the vibrancy of the ecosystem and growth of the place. While there is no indication that the various data points converge, our analysis leads us to three insights. One, legacy industry is disconnected from the new tech hub in an entrepreneurship ecosystem when the economy has shifted from the ‘Main street’ mode to the ‘digital’ mode. Two, while there are two recent success stories of Zappos and Switch SUPERNAP in Las Vegas, entrepreneurship activities remain moderate in spite of a bottom-up effort to build Downtown as a tech hub. Three, cluster advantages and positive network externalities do not seem to happen in unrelated industry in Las Vegas.
Persuasive Political Communication

Being able to communicate your message is key in political social work. Here we focus on best practices of persuasive political communication, including tailoring messages and communications to your audience. This chapter includes overall communication skills, such as framing, strategic use of language, and importance of being clear about your “ask”—what you want your target to do, support, or learn. Traditional media topics include definitions and benefits of various types of media, news hooks, selecting faces and visuals for a campaign, creating soundbites, and key terms such as on the record, off the record, and on background. Social media topics include the variety of available social media platforms and audiences, benefits, drawbacks, and communication strategies for each, as well as ways to keep abreast of emerging social media platforms and abilities. Interpersonal communication topics include public speaking, effective writing, and legislative testimony. Readers will develop a message, create media messaging, and practice “staying on message” as a candidate.
Drug-Excipient Interactions: Effect on Molecular Mobility and Physical Stability of Ketoconazole–Organic Acid Coamorphous Systems

The use of excipients other than polymers for enhancing the physical stability of amorphous active pharmaceutical ingredients (APIs) has largely been unexplored. We investigated several organic acids (oxalic, tartaric, citric, and succinic acid) for the purpose of stabilizing a weakly basic API, ketoconazole (KTZ), in the amorphous state. Coamorphous systems with each acid, in 1:1 KTZ–acid molar ratio, were prepared by spray drying. The interaction of KTZ with each acid was investigated by FT-IR, solid-state NMR, and quantum chemical calculations. Each acid exhibited ionic and/or hydrogen-bonding interactions with KTZ, and quantum chemical calculations provided a measure of the strength of this interaction. The α-relaxation times, a measure of molecular mobility, were determined by dielectric spectroscopy, and their crystallization propensity by variable temperature X-ray powder diffractometry. Crystallization was observed only in two systems, KTZ−oxalic salt and KTZ−succinic as a cocrystal. An increase i...
Current Status on Mode of Action Studies with Tagetitoxin

Pseudomonas syringae pv. tagetis was first described as the causal agent of a leaf spot disease of marigold (1). The bacterium has since been isolated from several other members of the Compositae, including common ragweed, sunflower, Jerusalem artichoke, and dandelion (7). Susceptible hosts exhibit small necrotic lesions, generally surrounded by chlorotic halos, and a highly characteristic apical chlorosis; both types of chlorosis result from the production of a toxin (6). Certain strains of P.s. pv. tagetis, when grown in a medium containing glucose and Woolley’s mineral salts (8), release into the culture filtrate a toxin which produces the apical chlorotic symptom in marigold seedlings. The toxin is non-host specific and has been given the trivial name tagetitoxin. A method for the purification of this toxin has been established (4), and a chemical structure proposed (5, 6).
Understanding and Improving the Trust in Results of Numerical Simulations and Scientific Data Analytics

With ever-increasing execution scale of parallel scientific simulations, potential unnoticed corruptions to scientific data during simulation make users more suspicious about the correctness of floating-point calculations than ever before. In this paper, we analyze the issue of the trust in results of numerical simulations and scientific data analytics. We first classify the corruptions into two categories, nonsystematic corruption and systematic corruption, and also discuss their origins. Then, we provide a formal definition of the trust in simulation and analytical results across multiple areas. We also discuss what kind of result accuracy would be expected from user’s perspective and how to build trust by existing techniques. We finally identify the current gap and discuss two potential research directions based on existing techniques. We believe that this paper will be interesting to the researchers who are working on the detection of potential unnoticed corruptions of scientific simulation and data analytics, in that not only does it provide a clear definition and classification of corruption as well as an in-depth survey on corruption sources, but we also discuss potential research directions/topics based on existing detection techniques.
Are we closer to the vision? A proposed framework for incorporating omics into environmental assessments.

Abstract Environmental science has benefited a great deal from omics-based technologies. High-throughput toxicology has defined adverse outcome pathways (AOPs), prioritized chemicals of concern, and identified novel actions of environmental chemicals. While many of these approaches are conducted under rigorous laboratory conditions, a significant challenge has been the interpretation of omics data in “real-world” exposure scenarios. Clarity in the interpretation of these data limits their use in environmental monitoring programs. In recent years, one overarching objective of many has been to address fundamental questions concerning experimental design and the robustness of data collected under the broad umbrella of environmental genomics. These questions include: (1) the likelihood that molecular profiles return to a predefined baseline level following remediation efforts, (2) how reference site selection in an urban environment influences interpretation of omics data and (3) what is the most appropriate species to monitor in the environment from an omics point of view. In addition, inter-genomics studies have been conducted to assess transcriptome reproducibility in toxicology studies. One lesson learned from inter-genomics studies is that there are core molecular networks that can be identified by multiple laboratories using the same platform. This supports the idea that “omics-networks” defined a priori may be a viable approach moving forward for evaluating environmental impacts over time. Both spatial and temporal variability in ecosystem structure is expected to influence molecular responses to environmental stressors, and it is important to recognize how these variables, as well as individual factor (i.e. sex, age, maturation), may confound interpretation of network responses to chemicals. This mini-review synthesizes the progress made towards adopting these tools into environmental monitoring and identifies future challenges to be addressed, as we move into the next era of high throughput sequencing. A conceptual framework for validating and incorporating molecular networks into environmental monitoring programs is proposed. As AOPs become more defined and their potential in environmental monitoring assessments becomes more recognized, the AOP framework may prove to be the conduit between omics and penultimate ecological responses for environmental risk assessments.
RNA tertiary structure energetics predicted by an ensemble model of the RNA double helix

Over 50% of residues within functional structured RNAs are base-paired in Watson-Crick helices, but it is not fully understood how these helices9 geometric preferences and flexibility might influence RNA tertiary structure. Here, we show experimentally and computationally that the ensemble fluctuations of RNA helices substantially impact RNA tertiary structure stability. We updated a model for the conformational ensemble of the RNA helix using crystallographic structures of Watson-Crick base pair steps. To test this model, we made blind predictions of the thermodynamic stability of >1500 tertiary assemblies with differing helical sequences and compared calculations to independent measurements from a high-throughput experimental platform. The blind predictions accounted for thermodynamic effects from changing helix sequence and length with unexpectedly tight accuracies (RMSD of 0.34 and 0.77 kcal/mol, respectively). These comparisons lead to a detailed picture of how RNA base pair steps fluctuate within complex assemblies and suggest a new route toward predicting RNA tertiary structure formation and energetics.
Phase 1 Trial of Retroviral-Mediated Transfer of the Human MDR-1 in Patients Undergoing High-Dose Chemotherapy and Autologous Stem Cell Transplantation

Normal bone marrow cells have little or no expression of the MDR p-glycoprotein product and are, therefore, particularly susceptible to killing by MDR-sensitive drugs such as the vinca alkaloids, anthracyclines, podophyllotoxins, and taxanes. In this report of a phase 1 clinical study performed at the Columbia-Presbyterian Medical Center, we demonstrate the safety and efficacy of transfer of the human multiple drug resistance (MDR) gene into hematopoietic stem cells and progenitors in bone marrow as a means of providing resistance of these cells to the toxic effects of cancer chemotherapy. One-third of the cells harvested from patients undergoing autologous bone marrow transplantation as part of high-dose chemotherapy treatment for advanced cancer were transduced with an MDR cDNA-containing retrovirus; these transduced cells were reinfused together with unmanipulated cells following the administration of the high-dose chemotherapy. High-level MDR transduction of BFU-E and CFU-GM derived from transduced CD34+ cells was demonstrated posttransduction and prereinfusion. However, only two of the five patients showed evidence of MDR transduction of their marrow at a low level at 10 weeks and 3 weeks, respectively, post transplantation. This relatively unexpected low level of efficiency of transduction was thought to be because the unmanipulated cells, infused at the same time as the transduced cells, might compete with the cytokine-stimulated transduced cells in repopulating the marrow. The MDR retroviral supernatant used was shown to be free of replication-competent retrovirus (RCR) before use, and all tests of patient samples post transplantation were negative for RCR. In addition, no adverse events with respect to marrow engraftment or other problems related to marrow transplantation were encountered. This study does indicate the feasibility and safety of bone marrow gene therapy with a potentially therapeutic gene, the MDR gene.
Gamma-Ray Pulsars in the Unidentified Population: The ‘Outer Gap’ Perspective

Given that pulsars and AGN are the only identified GeV point sources, it isn’t too bold to infer a substantial pulsar contribution to the Unidentified population. Specific models however predict differently the types of pulsars present in the observed sample. The dominant factors are the efficiency of spindown-gamma conversion, the high energy beam shape and the gamma ray spectrum. I’ll review briefly the main features of the `outer gap’ picture. Consequences for the relative numbers and Galactic distributions of the objects expected in the EGRET survey are then discussed, including young pulsars, `Geminga’s, binaries and millisecond pulsars. With recent counterpart work, we can already test and refine these predictions. The final, and main, point is that what we actually see teaches us in return important lessons about the pulsar physics. With up to a third of the spindown luminosity appearing as GeV gamma rays, these lessons give powerful constraints on the nature of the pulsar machine
Historical Evolution and Future Challenges of the Human Services Professions

The history of the human services professions in the 20th century reflects a continued increase in the demand for services among American families. Changing historical conditions, along with critic...
Integer Play and Playing with Integers

This chapter describes instances of play within a teaching episode on integer addition and subtraction. Specifically, this chapter makes the theoretical distinction between integer play and playing with integers. Describing instances of integer play and playing with integers is important for facilitating this type of intellectual play in the future. The playful curiosities arising out of integer addition and subtraction tended to be concepts that we think of prerequisite knowledge (e.g., magnitude or order, sign of zero) or knowledge that is more nuanced for integer addition and subtraction (e.g., how negative and positive integers can “balance” each other). Instances of integer play and playing with integers are connected to the work of mathematicians, highlighting the importance of play in school mathematics.
Identifying the need to refine the potential patient risk factors for niraparib-induced thrombocytopenia.

Abstract Objective Niraparib is a poly (ADP-ribose) polymerase inhibitor (PARP) approved for use in maintenance therapy for ovarian cancer that is associated with the unpredictable grade 3/4 thrombocytopenia. This study was conducted to refine patient dosing recommendations for niraparib based upon clinical practice observations of grade 3/4 thrombocytopenia. Methods and materials Six patient cases were reviewed to identify similarities in patient factors. An in vitro study was conducted using healthy volunteer blood spiked with Niraparib concentrations ranging from 0 ng/mL to 5000 ng/mL. Manual platelet counts were evaluated at different time intervals for each concentration and compared to untreated controls. Data was then analyzed based on percent change in platelet count versus untreated control for each concentration/time point. Results In three patients with body weight > 80 kg and platelet count >200 × 109/L, decreased creatinine clearance (CrCl) Conclusion The data suggests that renal insufficiency and hypoalbuminemia may be associated with the development of niraparib-induced thrombocytopenia. Moreover, the preliminary in vitro studies also demonstrated a concentration-dependent relationship between niraparib and direct toxicity to platelets.
Content review of pediatric ethics consultations at a cancer center.

Background/objectives Ethical challenges in pediatric oncology arise at every stage of illness. However, there are sparse data on the content of and reason for ethics consultations in the field. We sought to evaluate the content and characteristics of ethics consultations in pediatric patients at a cancer center. Design/methods We retrospectively identified ethics consultations performed for patients diagnosed with cancer at ≤21 years of age who were treated in the Department of Pediatrics from 2007 to 2017. Using an established coding schema, two independent reviewers analyzed the content of ethics consultation notes and identified core ethical issues and relevant contextual issues. Demographic, clinical, and consultation-specific data were also collected. Results Thirty-five consultations were performed for 32 unique patients. The most commonly identified ethical issues were obligation to provide nonbeneficial treatment (29%) and resuscitation preferences (26%). Communication conflicts were the most commonly identified contextual issue (40%). There were two themes that emerged repeatedly but were not a part of the original coding schema-four consultations (11%) that involved physicians questioning their obligation to provide potentially toxic treatment in the setting of poor patient/parent compliance, and two consultations (6%) related to complex risk-benefit analysis in the setting of an invasive procedure with uncertain benefit. Conclusions Pediatric ethics consultations are infrequent at this specialty cancer hospital. Ethical issues focused on treatment and end-of-life care and included a diversity of communication conflicts.
GENDER DISPARITIES IN CARDIOVASCULAR CARE OR MICROVASCULAR ISCHEMIA: THE RIDDLE OF NSTEMI IN WOMEN EXPLORED

Disparities in the delivery of healthcare result in lower quality of care and may affect morbidity and mortality. There are ongoing efforts to identify ethnic, socioeconomic and gender disparities in the evaluation and treatment of patients with cardiovascular disease. Non-ST segment elevation
Higher Order Bessel Beams Integrated in Time (HOBBIT) for Underwater Sensing and Metrology

This paper introduces a novel platform for coherently coupled OAM modes that can be dynamically controlled at rates in excess of 100's kHz. Results are provided for a 512-QAM constellation composed of two OAM states. © 2019 The Author(s)
The Exclusionary Discipline of American Indian and Alaska Native (AI/AN) Students with and Without Disabilities: A Civil Rights Data Collection (CRDC) National Analysis

The objective of this study was to assess the rates of disciplinary exclusion for American Indian and Alaska Native (AI/AN) students with and without disabilities, relative to Black, Hispanic/Latino, and White students, using 2015–2016 national level data from the U.S. Department of Education’s Civil Rights Data Collection (CRDC). We utilized quantitative analysis, including rates and weighted risk ratios, to assess disproportionality in disciplinary exclusions in terms of suspensions and expulsions. AI/AN students were disproportionately represented in exclusionary discipline practices, most substantially in comparison to White students, while AIAN students with disabilities were disproportionally represented in terms of suspension and expulsion risk compared to both Hispanic/Latino and White students, but not compared to Black students. The risk for AI/AN students, with and without disabilities, was highest for expulsion, the most extreme form of disciplinary exclusion. AI/AN students with and without disabilities remain overrepresented in exclusionary discipline. The Largest disproportionality was evident comparing AI/AN students and White students, with AI/AN students nearly nine times more likely to receive an in-school suspension, more than 10 times more likely to receive an out-of-school suspension, nearly 16 times more likely to receive more than one out-of-school suspension, and more than 30 times more likely to be expelled. Implications and recommendations to address issues related to this overrepresentation in disciplinary exclusion are provided.
Minimally invasive repair of a lumbar hernia utilizing the subcutaneous space only

Lumbar hernias are from weakened areas in the posterior lateral abdominal wall. Minimally invasive techniques are recommended for nonmidline abdominal wall hernias. Endoscopic methods utilizing the...
Immunotherapy for gastrointestinal malignancies: the journey does not end here!

Gastrointestinal malignancies represent a common and heterogeneous group of tumors and account for a high percentage of adult cancers. Over the past decades, early detection, advanced endoscopy and surgery, along with the additional benefit in some cases from perioperative treatment, have led to improved outcomes in localized disease. Disease recurrence and metastatic disease, as the primary presentation, are not uncommon and they carrie a very poor prognosis with median overall survival (OS) of less than 12 months from metastatic diagnosis with the exception of colon cancer where survival for stage IV disease is approaching 3 years.
“I just shared your responses”: Extending Communication Privacy Management Theory to Interactions with Conversational Agents

Conversational agents are increasingly becoming integrated into everyday technologies and can collect large amounts of data about users. As these agents mimic interpersonal interactions, we draw on communication privacy management theory to explore people's privacy expectations with conversational agents. We conducted a 3x3 factorial experiment in which we manipulated agents' social interactivity and data sharing practices to understand how these factors influence people's judgments about potential privacy violations and their evaluations of agents. Participants perceived agents that shared response data with advertisers more negatively compared to agents that shared such data with only their companies; perceptions of privacy violations did not differ between agents that shared data with their companies and agents that did not share information at all. Participants also perceived the socially interactive agent's sharing practices less negatively than those of the other agents, highlighting a potential privacy vulnerability that users are exposed to in interactions with socially interactive conversational agents.
Quantifying Multireference Character in Multicomponent Systems with Heat-Bath Configuration Interaction

Multicomponent quantum chemical methods seek to include nuclear quantum effects of select nuclei in quantum chemistry calculations by not invoking the Born-Oppenheimer approximation for these nuclei. In multicomponent methods, the inclusion of electron-proton correlation is essential for obtaining even qualitatively accurate protonic densities. However, most of the recently developed multicomponent methods have either used or obtained molecular orbitals from a single-reference mean-field wave function that neglects all electron-proton correlation that is analogous to using Hartree-Fock orbitals in a single-component framework. We examine the consequences of using Hartree-Fock orbitals in multicomponent calculations by developing the multicomponent heat-bath configuration interaction (HCI) method. Multicomponent HCI is a multicomponent selected configuration interaction (CI) technique that enables an accurate approximation of a complete active space or truncated CI wave function for systems with large active spaces. The multicomponent HCI method is shown to reproduce the ground-state protonic density of the HeHHe+, HCN, and FHF- systems when compared to reference grid-based calculations. For all three systems, the coefficient of the leading configuration in the wave function expansion is less than 0.95, indicating that all systems have multireference character. This is highly noteworthy as none of the systems have multireference character in a single-component framework and suggests that multireference character appears inherent to or at least more commonly in a multicomponent framework than a single-component framework. Even when natural orbitals are used rather than Hartree-Fock orbitals for the multicomponent HCI calculations, aspects of the multireference character remain for FHF- and HCN. Consequences and implications of the multireference character of multicomponent quantum chemical systems are discussed.
Silent sinus syndrome in children.

Abstract Introduction Silent sinus syndrome (SSS) is defined as a progressive enophthalmos and hypoglobus associated with maxillary sinus atelectasis. There is extremely limited literature describing SSS in children. The goals of this study are to characterize SSS in children through an IRB approval retrospective chart review of cases identified through a large health system-wide imaging database and to compare the presentation and outcomes of patients who underwent surgery versus those who were observed. Methods A radiology database of over 26 million reports from 2003 to 2017 was searched to identify children aged 1–18 years diagnosed with maxillary sinus hypoplasia or SSS on CT scan. Chart review was performed on the identified children including clinical presentation, eye symptoms, surgical treatment, and outcome. Results Eighty-three children were identified to have maxillary sinus hypoplasia. Eighty-one patients had maxillary sinus opacification and 57 patients had hypoglobus or enophthalmos characteristic of SSS. Thirty-two patients (47%) were seen by a specialist and 19 had surgery. The majority of patients (55%) had headache as their presenting symptom. There were no statistically significant differences in the clinical presentation between those who received surgery and those who were observed clinically. Conclusions Silent sinus syndrome can present at any age. The majority of cases of maxillary sinus hypoplasia will have the orbital floor changes characteristic of SSS. Headaches are a common presenting symptom. Close follow up of pediatric patients is advised and early intervention may be favorable to prevent long term orbital changes and complications.
P705 Bacterial sexually transmitted infections among women who inject drugs and exchange sex in king county, washington

Background Women who inject drugs are at elevated risk for many adverse health outcomes, including sexually transmitted infections (STIs). Exchange sex is prevalent in this population, but its independent effect on STIs is unclear. Methods We included data regarding the past year from cisgender women age Results The period prevalence of bacterial STI in the past 12 months was 8.1% in the full sample. On univariate analysis, STI prevalence was significantly higher among women who reported exchange sex than among those who did not (10.8% vs 4.0%; p=0.02) as was STI testing (53.4% vs 34.0%; p Conclusion In this sample of Seattle area women who inject drugs, exchanging sex for drugs or money was associated with double the odds of STI which could be a result of more frequent STI testing. Healthcare providers should prioritize making testing and treatment accessible and appropriate for women who exchange sex. Disclosure No significant relationships.
Hepatosplenic T-cell lymphoma: A rare but challenging entity

Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell neoplasm that most commonly arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. HSTCL is more common in adolescent and young adults and has a rapidly progressive clinical course and poor outcome due to its refractoriness to conventional chemotherapy regimens. Approximately 20% of the cases arise in the background of chronic immunosuppression or immune dysregulation. Patients commonly present with constitutional symptoms, hepatic and liver enlargement, and cytopenias; hematophagocytic syndrome can also occur. The most frequent chromosomal aberrations associated with HSTCL are isochromosome 7q and trisomy 8, and most cases harbor mutations in genes involved in chromatin modification or the JAK/STAT pathway. The rarity of this disease, along with lack of nodal involvement and presenting symptoms that mimic different entities including infectious etiologies, makes this lymphoma a significant diagnostic challenge. In this review, we highlight the clinical and pathologic features of HSTCL. Moreover, we summarize the results of recent molecular studies suggesting potential targets for novel therapeutics strategies.
Laser powder bed fusion of Inconel 718 on 316 stainless steel

Abstract The joining of Inconel 718 and 316 stainless steel has notable industrial importance. However, traditional arc-welding has many issues. In particular, the formation of the detrimental Nb-rich Laves phase in the heat affected zone can promote crack initiation and propagation, which leads to poor mechanical properties. The small heat input and the rapid solidification of laser powder bed fusion (PBF) has the potential to suppress this problem. Despite the infancy of the multi-material PBF, it is of interest to investigate the relationship among the process parameter, the microstructure at the materials joining point, and the mechanical performance. In this study, we used high-speed x-ray imaging to in-situ monitor the printing of Inconel 718 tracks on a 316H SS substrate via laser powder bed fusion, followed by post-build characterization and testing with SEM, XRD and nanoindentation. We observed that a higher linear energy density resulted in a more diffused interface and a smaller compositional gradient, but as a trade-off, generated more keyhole pores and thermal cracks. We also showed that the built layer exhibited chemical inhomogeneity at two length scales: a tens-of-μm-scale compositional vortex due to the melt flow, and a sub-μm-scale Nb-rich dendritic structure due to the non-equilibrium solidification that led to the formation of the Laves phase. It was inferred that the chemical inhomogeneity may benefit the mechanical properties at the interface by providing more interlocking between the two materials and also by limiting the effect of the brittle Laves phase to potentially short range.
Penile Pain in a Hemodialysis Patient

A 50-year-old man with a history of diabetes mellitus and ESKD on hemodialysis for 3 years presented with worsening discomfort in the genital region. He was afebrile and the physical examination demonstrated a circumcised phallus with a black necrotic area on the glans (Figure 1) with stenotic meatus. There was tenderness over the glans but no urethral discharge or ulcerations. He was almost anuric at baseline. Figure 1. Examination of the penis demonstrating a black necrotic area on the glans with stenotic meatus and surrounding erythema. Laboratory data were significant for a serum creatinine of 5.24 mg/dl, erythrocyte sedimentation rate of 120 mm/h (2–37), parathyroid hormone level of 81 pg/ml (<300 …
Multiple-source adaptation theory and algorithms

We present a general theoretical and algorithmic analysis of the problem of multiple-source adaptation, a key learning problem in applications. We derive new normalized solutions with strong theoretical guarantees for the cross-entropy loss and other similar losses. We also provide new guarantees that hold in the case where the conditional probabilities for the source domains are distinct. We further present a novel analysis of the convergence properties of density estimation used in distribution-weighted combinations, and study their effects on the learning guarantees. Moreover, we give new algorithms for determining the distribution-weighted combination solution for the cross-entropy loss and other losses. We report the results of a series of experiments with real-world datasets. We find that our algorithm outperforms competing approaches by producing a single robust predictor that performs well on any target mixture distribution. Altogether, our theory, algorithms, and empirical results provide a full solution for the multiple-source adaptation problem with very practical benefits.
Global modeling of hydrogen using GFDL-AM4.1: Sensitivity of soil removal and radiative forcing

Abstract Hydrogen (H2) has been proposed as an alternative energy carrier to reduce the carbon footprint and associated radiative forcing of the current energy system. Here, we describe the representation of H2 in the GFDL-AM4.1 model including updated emission inventories and improved representation of H2 soil removal, the dominant sink of H2. The model best captures the overall distribution of surface H2, including regional contrasts between climate zones, when vd(H2) is modulated by soil moisture, temperature, and soil carbon content. We estimate that the soil removal of H2 increases with warming (2–4% per K), with large uncertainties stemming from different regional response of soil moisture and soil carbon. We estimate that H2 causes an indirect radiative forcing of 0.84 mW m−2/(Tg(H2)yr−1) or 0.13 mW m−2 ppbv−1, primarily due to increasing CH4 lifetime and stratospheric water vapor production.
Tracing Nitrogen Metabolism in Mouse Tissues with Gas Chromatography-Mass Spectrometry

Nitrogen-containing metabolites including ammonia, amino acids, and nucleotides, are essential for cell metabolism, growth, and neural transmission. Nitrogen metabolism is tightly coordinated with carbon metabolism in the breakdown and biosynthesis of amino acids and nucleotides. Both nuclear magnetic resonance spectroscopy and mass spectrometry including gas chromatography-mass spectrometry (GC MS) and liquid chromatography (LC MS) have been used to measure nitrogen metabolism. Here we describe a protocol to trace nitrogen metabolism in multiple mouse tissues using 15N-ammonia coupled with GC MS. This protocol includes detailed procedures in tracer injection, tissue preparation, metabolite extraction, GC MS analysis and natural abundance corrections. This protocol will provide a useful tool to study tissue-specific nitrogen in metabolically active tissues such as the retina, brain, liver, and tumor.
Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

The analysis of whole-genome sequencing studies is challenging due to the large number of rare variants in noncoding regions and the lack of natural units for testing. We propose a statistical method to detect and localize rare and common risk variants in whole-genome sequencing studies based on a recently developed knockoff framework. It can (1) prioritize causal variants over associations due to linkage disequilibrium thereby improving interpretability; (2) help distinguish the signal due to rare variants from shadow effects of significant common variants nearby; (3) integrate multiple knockoffs for improved power, stability and reproducibility; and (4) flexibly incorporate state-of-the-art and future association tests to achieve the benefits proposed here. In applications to whole-genome sequencing data from the Alzheimer9s Disease Sequencing Project (ADSP) and COPDGene samples from NHLBI Trans-Omics for Precision Medicine (TOPMed) Program we show that our method compared with conventional association tests can lead to substantially more discoveries.
Timeline for Successful Commercialization of Thin-film Perovskite Solar Cells

Tandem technology has gained track during the last decade to surpass the theoretical efficiency of a single layer solar cell of 31%. However, there are some challenges that must be addressed before tandems can reach the commercialization level. A stable power conversion efficiency for a high bandgap solar cell compatible with a tandem structure is one of the main issues that prevents perovskites in reaching the market. Here, it is proposed the necessary steps to make stable tandem solar cells by having a 100% controlled process of a high bandgap perovskite solar cell, a hypothetical low bandgap perovskite solar cell, and their respective union into a tandem.
Effect of field geometry on profitability of automatic section control for chemical application equipment

Understanding how field geometry is related to over-application of inputs may help farmers make more informed decisions about investment in automatic section control (ASC) technology. The technology helps reduce input application overlap and therefore reduces input costs. The influence of field geometry on the profitability of ASC technology for chemical application was evaluated using overlap data estimated for 44 farm fields in Tennessee, USA. Reduction in overlap with ASC was defined as the difference in area sprayed controlling the entire boom as one section and area sprayed using seven-section ASC. Perimeter (m)-to-area (m2) ratio (P/A, m−1) was used to categorize estimated chemical overlap by field size and shape. Estimated median reductions in overlap with ASC were 3.00 % for fields with P/A = 0.01, 9.65 % for fields with P/A = 0.02 and 13.50 % for fields with P/A ≥ 0.03. For a typical size cotton farm in Tennessee, investing in ASC was not likely to be profitable for fields with P/A = 0.01 but was generally profitable for fields with P/A ≥ 0.02. The low reduction in overlap for P/A = 0.01 with ASC resulted in chemical savings that were too small to pay back the investment in ASC within the useful life assumed for the technology and provide a minimum rate of return. Thus, P/A as a measure of field geometry may be useful for evaluating investments in ASC technologies.
Experimental Aspects of Superconductivity: Editors’ Note

Several of the sessions of the course were devoted to discussions and demonstrations of laboratory techniques and the experimental aspects of superconductivity. During the day set aside for laboratory visits, Rolfe E. Glover III and his group at the University of Maryland demonstrated thin film techniques; Robert A. Hein, John E. Cox, Donald U. Gubser and Russel A. Meussner of the Naval Research Laboratory discussed preparation of alloys and demonstrated high critical field measurements using both adiabatic de-magnetization and dilution refrigerator cooling; and the Low temperature group at the National Bureau of Standards (James F. Schooley, Robert J. Soulen, Jr., and Jack H. Colwell) demonstrated heat capacity and d.c. magnetization measurements, and Josephson effect thermometry. In addition, during a lecture demonstration at Georgetown, Sidney Shapiro demonstrated an analog computer device built by Clark Hamilton that “solves” the Josephson equations in graphical form, for a variety of experimental conditions. During other laboratory demonstrations at Georgetown, a.c. susceptibility, d.c. magnetization, Giaever tunneling and Josephson effect detectors and radiators were demonstrated by William D. Gregory. Also, some actual experiments were shown using video tape recordings.
Towards an Energy Internet: A Game-Theoretic Approach to Price-Directed Energy Utilization

The growing interest towards internet-inspired research for power transmission and distribution invariably encounters the barrier of energy storage. Limitations of energy storage can be offset, to a degree, by reliable forecasting of granular demand leading to judicious scheduling involved and incentivized by appropriate pricing signals. The anticipation of energy demand and future system state is of great benefit in scheduling capacities offsetting storage limitations. In this paper, a game is formulated that shows the effect of the synergy between anticipation and price elasticity to achieve lower Peak-to-Average Ratios and minimize waste of energy. The results demonstrate that the final demand signal can be smoother and energy efficiency increased.