cssi/SciSciGPT-SciSciNet huggingface dataset:
Navicular body fractures: Computerized tomography findings and mechanism of injury

The case reports of five patients with signs and symptoms of a fracture of the tarsal navicular body are presented. Each patient underwent a computerized tomography examination to determine the extent of this fracture. Based on the computerized tomography findings, surgical or conservative management was carried out. The computerized tomography examination, combined with the patient's history, has shed new light on a previously undescribed mechanism of injury for this fracture.
Common Tendon and Muscle Injuries: Lower Extremity

The lower extremity is well suited to sonographic evaluation because the muscles and tendons are large and superficial and thus easily shown. Sonography is a focused examination, concentrating on the area of pain and clinical suspicion. Its advantages over MR imaging are better spatial resolution, capability of dynamic evaluation, and real-time guidance for percutaneous procedures. In addition, the advent of extended field of view imaging allows the entire length or cross-section of an area of interest to be shown, matching MR imaging's ability to display a large anatomic region. This article reviews the sonographic appearances of disorders of the muscles and tendons of the lower extremity.
Automatic detection of patient-ventilator asynchrony by spectral analysis of airway flow

Introduction: Adequate ventilatory support of critically ill patients depends on prompt recognition of ventilator asynchrony, as asynchrony is associated with worse outcomes. We compared an automatic method of patient-ventilator asynchrony monitoring, based on airway flow frequency analysis, to the asynchrony index (AI) determined visually from airway tracings. Methods: This was a prospective, sequential observational study of 110 mechanically ventilated adults. All eligible ventilated patients were enrolled. No clinical interventions were performed. Airway flow and pressure signals were sampled digitally for two hours. The frequency spectrum of the airway flow signal, processed to include only its expiratory phase, was calculated with the Cooley-Tukey Fast Fourier Transform method at 2.5 minute intervals. The amplitude ratio of the first harmonic peak (H1) to that of zero frequency (DC), or H1/DC, was taken as a measure of spectral organization. AI values were obtained at 30-minute intervals and compared to corresponding measures of H1/DC. Results: The frequency spectrum of synchronized patients was characterized by sharply defined peaks spaced at multiples of mean respiratory rate. The spectrum of asynchronous patients was less organized, showing lower and wider H1 peaks and disappearance of higher frequency harmonics. H1/DC was inversely related to AI (n = 110; r 2 = 0.57; P 10%, was associated H1/DC < 43% with 83% sensitivity and specificity. Conclusions: Spectral analysis of airway flow provides an automatic, non-invasive assessment of ventilator asynchrony at fixed short intervals. This method can be adapted to ventilator systems as a clinical monitor of asynchrony.
A representation for the orientation-dependent appearance of 3-D objects

A technique is presented for matching 3-D object models to a segmented region of an image taken from an unknown viewer direction. An appearance graph is defined to capture the appearance variations with viewpoint. The appearance graphs are created at multiple levels of abstraction, allowing for orientation determination from noisy images. The method for searching the appearance graphs for the most appropriate viewpoint consists of reducing feature differences between a given aspect and the segmented region at a given level of abstraction. Both the representation techniques and the search method are described, as well as a system implementing these methods. >
SummonChimera infers integrated viral genomes with nucleotide precision from NGS data

Background: Viral integration into a host genome is defined by two chimeric junctions that join viral and host DNA. Recently, computational tools have been developed that utilize NGS data to detect chimeric junctions. These methods identify individual viral-host junctions but do not associate chimeric pairs as an integration event. Without knowing the chimeric boundaries of an integration, its genetic content cannot be determined. Results: Summonchimera is a Perl program that associates chimera pairs to infer the complete viral genomic integration event to the nucleotide level within single or paired-end NGS data. SummonChimera integration prediction was verified on a set of single-end IonTorrent reads from a purified Salmonella bacterium with an integrated bacteriophage. Furthermore, SummonChimera predicted integrations from experimentally verified Hepatitis B Virus chimeras within a paired-end Whole Genome Sequencing hepatocellular carcinoma tumor database. Conclusions: SummonChimera identified all experimentally verified chimeras detected by current computational methods. Further, SummonChimera integration inference precisely predicted bacteriophage integration. The application of SummonChimera to cancer NGS accurately identifies deletion of host and viral sequence during integration. The precise nucleotide determination of an integration allows prediction of viral and cellular gene transcription patterns.
A Distributed Recording System Based on IEC 61850 Process Bus

IEC 61850 is the new standard for communications in substations that defines process bus and substation bus communications allowing the development of distributed waveform recording systems. The paper describes the different components of such systems and the distribution of functions between the devices included in it. Multiple Merging Units communicate over a 100 Mb Ethernet with a central computer that receives and records current and voltage waveforms with a sampling rate of 256 samples/cycle. The samples from the different merging units are then saved as a combined single COMTRADE file. The architecture of the system, triggering criteria, system performance and analysis tools are described in the paper.
Analysis of circuit-pack component reliability

The system under consideration is a field replaceable unit referred to as a circuit-pack used in various types of electronic switching equipment. The objective was to analyze field failure data on these circuit-packs in order to obtain estimates of the component reliabilities, which would then be used to predict the reliability of other configurations of the same types of components, i.e. new circuit-packs. In some instances the cause of failure was isolated only to some subset of the components on the pack. An approach to finding maximum likelihood estimates of component life distribution parameters from this type of masked system life data is described. In particular, it is assumed that component life is Weibull-distributed, and an iterative technique for maximizing the complex likelihood expression is presented. >
Androgen receptor-positive triple negative breast cancer: a unique breast cancer subtype.

Background The significance of androgen receptor (AR) expression in triple-negative breast cancer (TNBC) is unclear, and published studies so far have been inconclusive.
Analysis and synthesis of HVDC controls for robust stability of power systems

High voltage DC (HVDC) links have controllable characteristics with potential for affecting power system stability. This paper follows the robustness methodology procedure to analyze the stability robustness of HVDC controls in power systems over a range of operating conditions. A novel method to design power system controllers using the robustness methodology is also proposed. Numerical results for a sample test-system are obtained and compared with those obtained by conventional techniques.
Further Mothering: Reconceptualizing White Women Educators’ Work with Black Youth

As the percentage of youth of color in the nation's public schools continues to increase, so, too, does the urgency of preparing a predominantly white, female, middle class teaching force to work with racially and culturally diverse youth. Drawing upon an ethnographic study of an urban, youth-serving HIV/AIDS prevention and supports center, this article describes how two white women staffers engaged culturally responsive modes of care, support, and advocacy in order to address young people's emotional, developmental, and educational needs. Since both women performed motherly personas as they cared for and supported youth at the center, this article builds upon their experiences to develop “further mothering”—an adaptation of the “other mothering” tradition of black women—as a possible heuristic for analyzing white women educators’ culturally responsive work with black youth.
Effects of Microfilaments on DC Plasma Torches and Afterglows

In this paper, we investigate the effects of microfilaments on the operation of direct-current (dc) atmospheric-pressure nitrogen plasma torches. We measure the roto-vibrational temperatures of the first negative and second positive systems of the N2 and N2 + species, as well as the electron energy distribution function (EEDF) in the plasma plume and at several distances away from the source. The EEDF is measured using both planar and double-point Langmuir probes. We found that the operation of a dc nitrogen plasma torch in a mixed glow/microfilament regime results in the ejection of high-energy electron bullets from the torch nozzle. The frequency of these electron bullets outside the plasma coincides with the microfilament frequency. Furthermore, the microfilament frequency is shown to have a direct correlation with the N2 + roto-vibrational temperature. The electron bullets possess a highly non-Maxwellian EEDF and maintain their nonequilibrium energies while contained within the N2 substrate gas.
Prefixed tableaus and nested sequents

Nested sequent systems for modal logics are a relatively recent development, within the general area known as deep reasoning. The idea of deep reasoning is to create systems within which one operates at lower levels in formulas than just those involving the main connective or operator. Prexed tableaus go back to 1972, and are modal tableau systems with extra machinery to represent accessibility in a purely syntactic way. We show that modal nested sequents and prexed modal tableaus are notational variants of each other, roughly in the same way that Gentzen sequent calculi and tableaus are notational variants. This immediately gives rise to new modal nested sequent systems which may be of independent interest. We discuss some of these, including those for some justication logics that include standard modal operators.
Helminth and Arthropod Parasites of the Ground Skink, Scincella lateralis (Sauria: Scincidae), from Arkansas and Oklahoma, U.S.A

ABSTRACT: Seventy-five ground skinks, Scincella lateralis from 13 counties in Arkansas (n = 55) and McCurtain County, Oklahoma (n = 20) were collected and examined for helminth and arthropod parasites. Thirty-nine (52%) harbored 1 or more helminth or ectoparasite, including 3 (4%) with the trematode Brachycoelium salamandrae, 2 (3%) with the cestode Oochoristica eumecis, 2 (3%) with acuariid nematode larvae, 15 (20%) with the nematode Oswaldocruzia pipiens, 26 (35%) with the spirurid nematode Physaloptera squamatae, and 2 (3%) with ticks, Ixodes scapularis. Eleven (15%) were concurrently infected with P. squamatae and O. pipiens; O. eumecis and O. pipiens; B. salamandrae and larval acuariids; B. salamandrae and P. squamatae or O. pipiens; or I. scapularis and O. pipiens and/or P. squamatae. We document new host records for O. eumecis and acuariid larvae, and new distributional records are reported for O. eumecis, acuariid larvae, and P. squamatae. In addition, a summary of the helminth and arthropod p...
The interactional construction of desire as gender

Recently there have been spirited debates about the role of desire in the study of language, gender and sexuality – debates largely centred around the publication of Cameron and Kulick’s (2003) volume, Language and Sexuality. In the present paper, I address two important questions arising from this debate: defining evidence of desire in interaction, and the relationship of this ‘interactional desire’ to gender and masculinities more specifically. First, I argue for a definition of desire that goes beyond sexual desire, in a direction indicated by Cameron and Kulick; following Whitehead (2002:205-221), I suggest that another kind of desire that we should think about (in addition to interpersonal desire) is ontological desire -- essentially the desire to have or emulate qualities of a particular identity. Second, I use the notion of alignment to discover interactants ‘doing’ desire of different types in interaction. Finally, I argue that these alignments and how they are accomplished are not a separate part of masculine (and other gender) constructions of performances, but are at the centre of such identities. I use three excerpts, selected for their likelihood to have desire as an issue in the speech event, to illustrate these points.
A contact finite element formulation for biological soft hydrated tissues

As part of the highly complex numerical simulation of human joints, a finite element formulation for contact between layers of articular cartilage has been developed. A biphasic description of the cartilage is used, where the material is considered to be a porous, permeable solid matrix with fluid flowing through it. Governing equations and contact boundary conditions are summarized for this material before developing the finite element formulation from a Galerkin weighted residual statement. Lagrange multipliers are introduced to enforce the two kinetic continuity equations across the contact surface, and an iterative scheme is employed to determine the current contact area. Numerical examples are presented which demonstrate both that the appropriate continuity across the contact surface is enforced and that the contact surface definition is accurate.
Correlation of Factor VIIa Values With Factor VII Gene Polymorphism, Fasting and Postprandial Triglyceride Levels, and Subclinical Carotid Atherosclerosis

Background—Factor VII plays a pivotal role in coagulation. Factor VIIc levels were reported to be a risk factor for fatal coronary heart disease (CHD). Factor VIIc and VIIag levels were noted to be positively associated with plasma triglyceride (TG) levels and influenced by a VII gene polymorphism. The purpose of this study is to determine whether these associations are related to activated factor VII (factor VIIa). Methods and Results—Fasting and 3.5-hour postprandial samples from 216 cases with subclinical atherosclerosis and 341 matched controls selected from the ARIC cohort were assayed for levels of factors VIIa, VIIc, and VIIag and TG, and factor VII codon 353 gene polymorphism. The level of factor VIIa was higher in Arg/Arg than in Arg/Gln+Gln/Gln genotypes, and the difference was in accord with that of factors VIIag and VIIc. However, the factor VIIa difference was statistically insignificant. Factor VIIa values were not correlated with fasting or 3.5-hour postprandial TG levels, nor were they ass...
Reply to comment by A. Douglas on ‘Systematic determination of earthquake rupture directivity and fault planes from analysis of long-period P-wave spectra’

SUMMARY We respond to the comments by Douglas regarding our earlier paper by emphasizing that our automated method was intended to distinguish between the primary and auxiliary fault planes in earthquake focal mechanisms and does not always produce reliable results for rupture velocity and rupture length.
Laser emission of Er(3+) in ZrF4-based fluoride glass

Laser emission is reported in an Er+3-doped ZrF4-based fluoride glass often referred to as ‘heavy metal fluoride glass’ (HMFG). The laser operates at room temperature at a wavelength of 2.78μm. The glass is a standard ZBLAN formulation in which all of the LaF3 (4 mol%) is replaced by ErF3. Glass preparation, spectroscopy, and laser data are presented and discussed.
Lignosulfonic Acid-Doped Polyaniline (Ligno-PaniTM) — A Versatile Conducting Polymer

The use of renewable natural resources to develop or improve existing technologies is an important area of research to the scientific community. The availability and functionality of these resources very often make it possible to reduce the cost and improve the properties of existing products. One such natural resource that has received a great deal of attention over the years is lignin.
Systemic coagulation effects associated with intra-arterial infusions of low doses of streptokinase for peripheral arterial occlusions

Streptokinase (SK) arterial infusion has become an increasingly used method in the therapy of peripheral arterial occlusive disease. Dosage regimens and durations of therapy are extremely variable. The degree of alteration in the coagulation system has not been adequately addressed. Such alterations might have profound significance regarding patient selection, nature of contraindica tions and degree of toxicity. We have systematically studied the effects of very low doses of SK given intra-arterially in peripheral arterial occlusive disease states. Our detailed studies demonstrate a profound systemic effect on the clot ting mechanism and function in such patients with marked lowering of fibrino gen, depletion of plasminogen and overall hypocoagulability. The effects of these findings on the clinical aspects of this therapeutic technique are discussed.
Reaction Time and Movement Time in Four Large Muscle Movements

Abstract The relation between RT and MT was determined in 70 male college students. Four types of discrete movement were studied. Reliabilities were high, namely r = .87 to .95 uncorrected. The correlations between RT and MT ranged from r = −.06 to .23, and none was statistically significant. It was concluded that individual differences in ability to react quickly and ability to move quickly are almost entirely unrelated.
RUPTURED CASEOUS MITRAL ANNULAR CALCIFICATION PRESENTING AS A MOBILE MASS

The annulus of the mitral valve commonly becomes calcified in the elderly. Mitral annular calcification (MAC) may be found in 10% of older patients and 40% of patients with end-stage renal disease (ESRD) referred for echocardiography. Caseous calcification of the mitral annulus (CCMA) may present as
Synthetic miR-16-5p does not act as a reverse transcriptase co-factor to enhance detection of small RNA

Failure to detect low-abundance microRNAs (miRNAs), for example, in circulating plasma, may occur for a variety of reasons, including presence of enzyme inhibitors. Recently, we received the unusual but intriguing suggestion that miR-16-5p acts as a co-factor of reverse transcriptases, facilitating more efficient reverse transcription of miRNAs and thus enhanced detection of low-abundance miRNAs. We tested this hypothesis by incubating reverse transcriptase with several concentrations of synthetic miR-16-5p and then performing stem-loop RT-qPCR with serial dilutions of miRNA osa-MIR168a. Our results do not support a role for miR-16 as a co-factor of reverse transcriptase.
Lateral Sealing of Faults and Gas Reservoir Formation in Volcanic Rocks in Xujiaweizi Fault Depression

Deep layers of the Xujiaweizi fault depression refer to the layers below 1st and 2nd Member of the Lower Cretaceous Quantou Formation (K1q1+2),in which there are 3 sets of volcanic rock reservoir: the Huoshiling Formation (K1hs),1st and 3rd Member of the Yingcheng Formation (K1yc1 and K1yc3). At present larger scale gas reservoirs have been found in the 2 sets of volcanic rocks in K1yc. Fault systems in the Xujiaweizi fault depression are complex and obviously control gas reservoir formation. Reservoir-controlling faults controlled volcanic fissure eruption in the early stage and experienced strong activity in late K1q—early K1qn. Faults which sealed in the top in regional cap rocks were volcanic conduit when they were formed. There are no obvious fault planes. Fault breccia zone was formed by fault activity in late K1q—early Qingshankou Formation(K1qn). Gas migrated vertically along faults on a large scale and then accumulated in volcanic rocks of K1yc. Because of the poor lateral seal ability of fault breccia zone,gas was occluded laterally by conglomerates which had poor physical properties in K1yc4. For normal faults,gas mainly accumulated in the bottom wall,while for reverse faults mainly accumulated in the hanging wall. Xuzhong strike-slip fault is main reservoir-controlling fault. Gas that accumulated in two walls is characteristic of "one increases as another decreases" because of the changes of dip and property of faults. This accumulation regularity of gas has important directive significance for exploration deployment,gas reservoir borders determination and reserves submission.
Experimental Investigation of Mechanical Properties of Asphalt Plug Joint Materials

This paper provides an experimental evaluation on the mechanical properties of BJ200-Green asphalt plug joint materials.Focus is on stability at high temperature and flexibility at low temperature of the binder and the joint mixture.Binder tests indicates that the softening point is 84 ℃,adhesion strength at low temperature is 0.85 MPa.The binder can relax 80% of initial force within 60 s,indicating good relaxation performance.Rutting test on the mixture shows that permanent deformation is less than 15% after subjected to 10 000 passes of wheel loading.Three point bending test indicates that the maximum bending strain at failure is larger than 20 000 μm/m.The data obtained confirms the good performance of mixture at high and low temperature.
Abstract 48: Diabetic Patients with Acute Coronary Syndrome Have Better 6 Month and 2 Year Outcomes with Revascularization Compared to Medical Therapy Alone

Background: Recent trials suggest patients with diabetes may do better with coronary-artery bypass graft (CABG); however long-term trends in the rates of CABG and percutaneous coronary intervention (PCI) compared to medical therapy from a real-world population are not well known. Methods: We analyzed 1003 DM patients admitted with acute coronary syndrome (ACS) from 1999 to 2008 at a tertiary care center. Rates of revascularization were examined by study year. In addition in-hospital, 6mo and 2yr outcomes were obtained by phone interview and medical chart review. Multiple logistic regression models were created for 6mo and 2yr outcomes, adjusting for variables known to be associated with mortality. Results: Of 1003 DM/ACS patients, 505 were medically managed, 399 received percutaneous coronary intervention (PCI) and 99 received a coronary-artery bypass graft (CABG). At baseline, the medical group was the oldest and sickest. Rates of CABG increased particularly in the years between 2001 and 2003, and rates of PCI increased from 2003 to 2006. Both types of revascularization procedures have declined in recent years and medical management accounts for over 50% of diabetic ACS patients. (Figure 1) At 6mo, both CABG (p=0.02, OR 0.17, 95%CI 0.04-0.74) and PCI (p=0.03, OR 0.46, 95%CI 0.23-0.92) reduced mortality among DM patients after controlling for the GRACE risk score. A similar reduction in mortality was noted at 2yr for CABG (p=0.01, OR 0.35, 95%CI 0.16-0.77) and PCI (p=0.03, OR 0.62, 95%CI 0.40-0.95) compared to medical therapy alone. Conclusions: Rates of revascularization among DM/ACS patients have declined in recent years, particularly for CABG. Both types of revascularization are associated with significant survival benefit, suggesting improving access to these procedures among DM/ACS patients is warranted. ![Graphic][1] [1]: /embed/inline-graphic-1.gif
An Instructor’s Guide to (Some of) the Most Amazing Papers in Neuroscience

Although textbooks are still assigned in many undergraduate science courses, it is now not uncommon, even in some of the earliest courses in the curriculum, to supplement texts with primary source readings from the scientific literature. Not only does reading these articles help students develop an understanding of specific course content, it also helps foster an ability to engage with the discipline the way its practitioners do. One challenge with this approach, however, is that it can be difficult for instructors to select appropriate readings on topics outside of their areas of expertise as would be required in a survey course, for example. Here we present a subset of the papers that were offered in response to a request for the "most amazing papers in neuroscience" that appeared on the listserv of the Faculty for Undergraduate Neuroscience (FUN). Each contributor was subsequently asked to describe briefly the content of their recommended papers, their pedagogical value, and the audiences for which these papers are best suited. Our goal is to provide readers with sufficient information to decide whether such articles might be useful in their own classes. It is not our intention that any article within this collection will provide the final word on an area of investigation, nor that this collection will provide the final word for the discipline as a whole. Rather, this article is a collection of papers that have proven themselves valuable in the hands of these particular educators. Indeed, it is our hope that this collection represents the inaugural offering of what will become a regular feature in this journal, so that we can continue to benefit from the diverse expertise of the FUN community.
Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph.

Background Water-soluble components in mesenteric lymph have been implicated in the pathophysiology of acute lung injury and distal organ failure following trauma and haemorrhagic shock. Proteomics analyses have recently shown similarities and specificities of post-trauma/haemorrhagic shock lymph and plasma. We hypothesise that the metabolic phenotype of post-trauma/haemorrhagic shock mesenteric lymph and plasma share common metabolites, but are also characterised by unique features that differentiate these two fluids. Materials and methods Matched samples were collected from 5 brain-dead organ donors who had suffered extreme trauma/haemorrhagic shock. Metabolomics analyses were performed through ultra-high performance liquid chromatography mass spectrometry. Results Overall, 269 metabolites were identified in either fluid. Despite significant overlapping, metabolic phenotypes of matched lymph or plasma from the same patients could be used to discriminate sample fluid or biological patient/traumatic-injury origin. Metabolites showing relatively high levels in both fluids included markers of haemolysis and cell lysis secondary to tissue injury. Discussion High positive correlations were observed between the quantitative levels of markers of systemic metabolic derangement following traumatic/haemorrhagic hypoxaemia, such as succinate, oxoproline, urate and fatty acids. These metabolites might contribute to coagulopathies of trauma and neutrophil priming driving acute lung injury. Future studies will investigate whether the observed compositional specificities mirror functional or pathological adaptations after trauma and haemorrhage.
Active ETFs: To Be or Not to Be?

Investors anxiously anticipated the debut of actively managed exchange-traded funds (ETFs) in 2008, expecting them to succeed as well as their counterparts in the mutual fund industry. In the end, the reality didn’t match the expectations, as actively managed funds are still languishing in the basement of the ETF industry. The first goal of this chapter is to identify the factors responsible for this state of affairs, particularly an issue around transparency that remains the focus of contention between the Securities and Exchange Commission (SEC) and fund sponsors pursuing approval of new active ETFs.
Parents at‐risk and their children: intersections of gender role attitudes and parenting practices

Existing research demonstrates that parent and child gender may influence important aspects of family relationships; however, most research in this area has been conducted with non-clinical samples. As clinicians, it is important to consider how gender impacts family relationships, particularly among vulnerable families. This study examined the intersections of gender role attitudes and parenting practices among 34 parents involved with the child welfare system and referred for clinical intervention. Using a mixed methods design, themes regarding gender role beliefs and parenting practices were found through qualitative interviews with parents. Findings suggested that fathers felt responsible for financially providing for their families and expressed challenges in communicating with mothers, and mothers described challenges they face because of a lack of father involvement. Parents also discussed a perceived need to monitor daughters closely while fostering the independence of their sons. Results of the qualitative analyses were supported by quantitative findings indicating significant differences in harsh and inconsistent discipline practices and clear expectations for girls compared to boys. The discussion addresses implications for clinicians, including how a feminist family therapy perspective may help promote client influence over traditional gender norms by questioning gender role attitudes and exploring alternate narratives that may impact family dynamics.
E-MACs: towards more secure and more efficient constructions of secure channels

In cryptography, secure channels enable the confidential and authenticated message exchange between authorized users. A generic approach of constructing such channels is by combining an encryption primitive with an authentication primitive (MAC). In this work, we introduce the design of a new cryptographic primitive to be used in the construction of secure channels. Instead of using general purpose MACs, we propose the employment of special purpose MACs, named "∈-MACs". The main motive behind this work is the observation that, since the message must be both encrypted and authenticated, there can be a redundancy in the computations performed by the two primitives. If this turned out to be the case, removing such redundancy will improve the efficiency of the overall construction. In addition, computations performed by the encryption algorithm can be further utilized to improve the security of the authentication algorithm. In this work, we show how ∈-MACs can be designed to reduce the amount of computations required by standard MACs based on universal hash functions, and show how ∈-MACs can be secured against key-recovery attacks.
Adjuvant palbociclib (P) plus endocrine therapy (ET) for hormone receptor positive (HR+) breast cancer: A phase II feasibility study.

TPS654 Background: Cell cycle inhibition is a target of interest for novel cancer therapeutics. P is an orally active inhibitor of CDK4/6, causing cell cycle arrest at the G1-S transition. In an in...
Machine Learning-as-a-Service and Its Application to Medical Informatics

Machine learning as an advanced computational technology has been around for several years in discovering patterns from diverse biomedical data sources and providing excellent capabilities ranging from gene annotation to predictive phenotyping. However, machine learning strategies remain underused in small and medium-scale biomedical research labs where they have been collaboratively providing a reasonable amount of scientific knowledge. While most machine learning algorithms are complicated in code, theses labs and individual researchers could accomplish iterative data analysis using different machine learning techniques if they had access to highly available machine learning components and powerful computational infrastructures. In this contribution, we provide a comparison of several state-of-the-art Machine Learning-as-a-Service platforms along with their capabilities in medical informatics. In addition, we performed several analyses to examine the qualitative and quantitative attributes of two Machine Learning-as-a-Service environments namely “BigML” and “Algorithmia”.
The local market perception of firm risks during cross‐listing events

We examine the local investors’ perceptions on the relative idiosyncratic risks around cross‐listing events. We find that increases in relative firm‐specific risks around the listing date are temporary and small for Level I American depositary receipts (ADRs) while Level III ADRs have the most variations. For exchange‐listed ADRs from emerging markets, there is a significant decrease in the relative firm‐specific risk in the year prior to listing, which increases during the cross‐listing, while there are only significant increases in relative firm‐specific risks for developed market firms. We interpret these as evidences of negative relationship between firm opaqueness and relative firm‐specific risks.
Exploiting a novel algorithm and GPUs to break the ten quadrillion pairwise comparisons barrier for time series motifs and joins

Time series motifs are approximately repeated subsequences found within a longer time series. They have been in the literature since 2002, but recently they have begun to receive significant attention in research and industrial communities. This is perhaps due to the growing realization that they implicitly offer solutions to a host of time series problems, including rule discovery, anomaly detection, density estimation, semantic segmentation, summarization, etc. Recent work has improved the scalability so exact motifs can be computed on datasets with up to a million data points in tenable time. However, in some domains, for example seismology or climatology, there is an immediate need to address even larger datasets. In this work, we demonstrate that a combination of a novel algorithm and a high-performance GPU allows us to significantly improve the scalability of motif discovery. We demonstrate the scalability of our ideas by finding the full set of exact motifs on a dataset with one hundred and forty-three million subsequences, which is by far the largest dataset ever mined for time series motifs/joins; it requires ten quadrillion pairwise comparisons. Furthermore, we demonstrate that our algorithm can produce actionable insights into seismology and ethology.
"You can't be any poorer than dead": difficulties in recognizing artificial nutrition and hydration as medical treatments.

The President's Commission Report Deciding to Forego Life-Sustaining Treatment comes down squarely in favor of two propositions: 1) artificial provision of nutrition and hydration are medical treat...
Placebo and Nocebo in Cardiovascular Health: Implications for Healthcare, Research, and the Doctor-Patient Relationship

Despite treatments proven effective by sound study designs and robust end points, placebos remain integral to elicit effective medical care. The authenticity of the placebo response has been questioned, but placebos likely affect pain, functionality, symptoms, and quality of life. In cardiology, placebos influence disability, syncope, heart failure, atrial fibrillation, angina, and survival. Placebos vary in strength and efficacy. Compliance to placebo affects outcomes. Nocebo responses can explain some adverse clinical outcomes. A doctor may be an unwitting contributor to placebo and nocebo responses. Placebo and nocebo mechanisms, not well understood, are likely multifaceted. Placebo and nocebo use is common in practice. A successful doctor-patient relationship can foster a strong placebo response while mitigating any nocebo response. The beneficial effects of placebo, generally undervalued, hard to identify, often unrecognized, but frequently used, help define our profession. The role of the doctor in healing, above the therapy delivered, is immeasurable but powerful. An effective placebo response will lead to happy and healthy patients. Imagine instead the future of healthcare relegated to a series of guidelines, tests, algorithms, procedures, and drugs without the human touch. Healthcare, rendered by a faceless, uncaring army of protocol aficionados, will miss an opportunity to deliver an effective placebo response. Wise placebo use can benefit patients and strengthen the medical profession.
Risk Factors for and Prediction of Hypoxemia during Tracheal Intubation of Critically Ill Adults

Rationale: Hypoxemia is a common complication during tracheal intubation of critically ill adults and is a frequently used endpoint in airway management research. Identifying patients likely to exp...
The growth of climate change misinformation in US philanthropy: evidence from natural language processing

Two of the most consequential developments affecting US politics are (1) the growing influence of private philanthropy, and (2) the large-scale production and diffusion of misinformation. Despite their importance, the links between these two trends have not been scientifically examined. This study employs a sophisticated research design on a large collection of new data, utilizing natural language processing and approximate string matching to examine the relationship between the large-scale climate misinformation movement and US philanthropy. The study finds that over a twenty year period, networks of actors promulgating scientific misinformation about climate change were increasingly integrated into the institution of US philanthropy. The degree of integration is predicted by funding ties to prominent corporate donors. These findings reveal new knowledge about large-scale efforts to distort public understanding of science and sow polarization. The study also contributes a unique computational approach to be applied at this increasingly important, yet methodologically fraught, area of research.
Global Competition for Work: Recent Preparations in Wales

This paper argues that a global paradigm shift is underway involving work; that the trend of people migrating to find life-sustaining/enhancing work is evolving to a future state where work will migrate to find a workforce capable of adding value. The transition in Wales after the loss of its steel and coal industries is used to highlight the processes involved in building an infrastructure to attract inward investment and create jobs. The paper concludes with a call for research to help us understand the dynamics involved in successfully competing for work.
Properties of the beta regression model for small area estimation of proportions and application to estimation of poverty rates

Linear mixed effects models have been popular in small area estimation problems for modeling survey data when the sample size in one or more areas is too small for reliable inference. However, when...
ST ELEVATION MYOCARDIAL INFARCTION IN DEXTROCARDIA: A CLINICAL CHALLENGE

Dextrocardia is a rare congenital cardiac malrotation syndrome characterized by abnormal positioning of the heart in the right hemithorax. While most cases have structurally normal hearts, the malrotation may pose important diagnostic and therapeutic challenges in the setting of acute coronary
Espantando a los Uriburu

El presente articulo analiza las multiples representaciones de la figura femenina en Espantapajaros… al alcance de todos (1932). La mirada del flâneur latinoamericano, convertido en residente permanente de la ciudad de Buenos Aires, descompone y muestra las contradicciones socioculturales de la ciudad. La figura femenina, lejos de ser la posesion de este residente, se erige en voz y cuerpo autonomos que lo contagian de otra forma de experimentar la modernidad. Pionero, en este sentido, es el analisis de las relaciones entre Espantapajaros… al alcance de todos y dos figuras historicas que representaron para Girondo formas de vida opuestas presentes en el texto: Jose Felix Benito Uribru (1868-1932) y Norah Lange (1905-1972). Asimismo, se analizan las multiples representaciones de la figura femenina que muestran alternativas existenciales a la modernidad burguesa. Es la figura femenina singular, cuyo pronombre no es sino “ella”, la que se resiste a cualquier intento de homogenizacion por parte de la ley identitaria.
The Mobile College Student--Peril or Promise.

The Challenges of the New Mobility One of the unique and relatively unstudied challenges facing administrators of American institutions of higher education today is that relating to student mobility. This phenomena is beginning to take on the characteristics of many of the other aspects of the higher education enterprise; namely, diversity, complexity, and magnitude. While several recent studies (Knoell and Medsker1; Gossman, Nobbe, Patricelli, Schmid, and Steahr2; and Willingham and Findikyan3) have dealt with this challenge, little systematic thought has been devoted on the part of administrators to coping with the total issue and to develop institutional strategies to meet the challenges. As indicated in the title of this article, the new "modus operandi" which we are finding in our student body holds both promise and peril for institutions of higher education, the individual student, and for society as a whole. The peril that this article refers to, but does not attempt to elaborate on, relates to the conditions of instability and hysteria that can be created by relatively small numbers of mobile, verbal, and activist students moving from campus to campus creating their own brand of truth and relevance. The free exchange of new ideas and new philosophies brought to the campuses by transfer students holds new promise for a new age of student enlightenment and a breaking of the restricting bonds of parochial thinking whether sectionalism, classism, racism, or religion. This same exchange, however, perpetrated by the extremists and those bent upon disruption and destruction for its own sake surely must be viewed by all members of the academic community as one of its most serious problems. At one time most of the students who began their education at an institution of higher education either completed their program at that institution or left the system entirely. The emergence of the junior college on the American scene at the turn of the century and the comprehensive community college which began to appear some time in the late 1940's intro-
Risk-Taking Behaviors in Adolescents With Chronic Cardiac Conditions: A Scoping Review.

Abstract Problem Advances in treatment and therapy for children with chronic cardiac conditions have extended their life expectancy. Risk-taking behavior among adolescents requires further exploration. Researchers conducted a scoping review to address a literature gap specific to risk-taking behavior among adolescents with chronic cardiac conditions. Eligibility criteria Sources were limited to (1) human subjects, (2) English language or translatable to English, (3) adolescents without age restrictions, (4) all research designs and (5) presence of a chronic cardiac condition. Sample Searches of six electronic databases (CINAHL Plus Full Text, PubMed, Web of Knowledge, Scopus, ProQuest and Grey Literature Report) were conducted to verify the empirical literature between 1975 and 2018. Seventeen sources were included in this review. Results Among the 17 sources, 12 sources examined risk-taking behavior by self-report among adolescents with chronic cardiac conditions. Tobacco, alcohol and/or other drug use and physical inactivity were the most prevalent risk-taking behaviors identified through this review. Conclusions Findings from this scoping review describe the types of risk-taking behaviors that adolescents with chronic cardiac conditions are engaging in, highlight similarities when compared to other types of chronic conditions, and serve as a foundation for future research among this population. Implications Discussion of risk-taking behaviors should be integrated into each healthcare encounter beginning in early adolescence and continuing through transition to adulthood and adult health care. Qualitative research studies may serve as an effective method by which to explore risk-taking behavior among adolescents with chronic cardiac conditions in greater detail.
Multiple Myeloma Presenting as Recalcitrant Macular Edema

Purpose:This article presents an unusual case of ocular involvement of multiple myeloma masquerading as macular edema associated with diabetic retinopathy.Methods:A report of a single case.Results:...
Design of Hybrid Variable Flux Motors for Enhanced Wide-Speed Performance

The paper presents a detailed study about Variable Flux Machines (VFMs) with series rare-earth and AlNiCo magnets. A tangentially magnetized series hybrid VFM is first compared to a VFM with AlNiCo magnets, and the Finite Element Analysis (FEA) results show the benefits of the series hybrid configuration in terms of higher power capability at high speeds, more stable magnet operation at full load and lower magnetization current requirement. The effects of saliency, magnet orientation and magnet grade on the hybrid VFM performance are then investigated using FEA. Among the various simulated designs, the V-shaped hybrid VFM with normal saliency and higher grade rare-earth magnets is found to have the best overall performance. The selected design is then optimized using Genetic Algorithm (GA) based procedure that aims to maximize the machine output torque, while satisfying the VFM demagnetization/magnetization requirements. The optimized design can achieve high torque at low speeds and maintain constant power at high speeds by utilizing lower magnetization levels.
Recent Advances in Genetic Improvement of Jatropha curcas: A Potent Biodiesel Plant

Jatropha curcas is an ideal plant species for biodiesel production. It grows on the waste land and in adverse climatic conditions. The lack of hybrids and high yielding genotypes for yield and oil content is the main problem in large-scale cultivation of J. curcas. Therefore, genetic diversity assessment is pre-requisite for the development of superior variety through breeding program. Limited efforts have been carried out for the genetic improvement with both conventional breeding and biotechnology approaches. In vitro mass propagation is commonly used to multiply uniform plants of elite germplasm. Further regeneration or direct organogenesis from in vitro explant is pre-requisite for the development of transgenic plants. This chapter is the compilation of information on genetic diversity assessment, conventional breeding, and biotechnological approaches for its genetic improvement.
COVID-19 and Decompressive Hemicraniectomy for Acute Ischemic Stroke.

Background and Purpose: Young patients with malignant cerebral edema have been shown to benefit from early decompressive hemicraniectomy. The impact of concomitant infection with coronavirus diseas...
Nystagmus and Vertigo in Acute Vestibular Migraine Attacks: Response to Non-Invasive Vagus Nerve Stimulation.

Objective Vestibular migraine (VM) is the most common neurologic cause of vertigo in adults, but there are no currently-approved rescue therapies. This study describes the benefits of non-invasive vagus nerve stimulation (nVNS) on vertigo, headache, and nystagmus during VM attacks. Methods Case series of four VM patients who were evaluated during acute VM episodes in a tertiary referral neurology clinic between February 2019 and January 2020. They underwent bedside neuro-otologic examination, and graded the severity of vertigo and headache using a 10-point visual-analog scale (VAS; 0-no symptoms, 10-worst ever symptoms), before and 15 minutes after nVNS. Results Average vertigo severity was 5 (median 4.5) before, and 1.5 (median 0.5) after nVNS. Mean headache severity (three patients) before treatment was 4 (median 4), and 0.7 (median 0) after. Spontaneous right-beating nystagmus (Patient 1) nystagmus, upbeat nystagmus (Patient 2), and positional nystagmus (Patient 3) resolved with nVNS. Baseline left-beating nystagmus in Patient 4 from previous vestibular neuritis damped during acute VM but returned to baseline following nVNS. In all four patients, ictal nystagmus resolved, and examination findings returned to baseline. Conclusions This study suggests nVNS may ameliorate vertigo and headache, as well as nystagmus associated with VM attacks. Larger, sham device-controlled studies are needed to elucidate the benefits of nVNS in VM.