cssi/SciSciGPT-SciSciNet huggingface dataset:
Admirable dishonesty in medical practice

Historically, the ethics of dishonesty within the physician-patient relationship has been analyzed largely from the deontological and consequentialist viewpoints. In this essay I offer a new exploration of dishonesty from the recently developed Virtue Ethics of Care perspective. First, I will explain and justify a general prescription for honest conduct within the relationship. Next, I will explore the conditions under which the Virtue Ethics of Care would find acts of dishonesty in medical practice to be admirable. Here, the moral distinction between lying and deception will be discussed. Then, two special contexts in medical practice, paternalistic dishonesty and patient dishonesty, will be analyzed. I will close with a discussion of the role of trust in the relationship and how it acts to prevent the Virtue Ethics of Care from sliding down the path toward objectionable acts of dishonesty.
Census trends in AIDS specialty units.

As HIV disease evolves into a chronic and manageable disease, monitoring trends in HIV/AIDS inpatient use will become an important tool clinicians can use to analyze the need for organizational changes in patients care delivery. Monitoring census trends can assist nurses in developing plans of care and evaluating outcome in HIV patients. Nurse managers of AIDS Specialty Units (ASUs) are at the forefront of identifying current inpatient use trends. This article investigates census trends in selected ASUs from the perspective of ASU nurse managers and describes the factors that nurse managers believe to have influenced census trends. Implications for further research are provided.
Radiation Reaction Recall Following Simvastatin Therapy: A New Observation*

Abstract A 60-year-old woman was treated postoperatively for carcinoma of the gall bladder with a split course of radiotherapy. The tumour dose (TD) was 61.2 Gy in 34 fractions delivered by an anterior and two lateral wedge fields with 60 Co; the D max was 70% of TD for the anterior field and 150% of the TD at the thin edge of the wedges. She also underwent 5-FU and leucovorin chemotherapy. No skin reaction was seen during radiotherapy or in 1 year of follow-up. A year after radiotherapy she was treated for hypercholesterolaemia by simvastatin. Within 2–3 days a severe skin and subcutaneous reaction developed in the lateral radiation fields but not in the anterior field. To our knowledge, recall of skin radiation reaction after simvastatin therapy has not been previously reported.
Introduction: Organized Crime Penetrations of Legitimate Businesses

This book endeavors to explain the ways in which organized crime penetrates and infiltrates legitimate business enterprises, industries, and commercial sectors of the economy of the United States. It is widely acknowledged that organized crime is a threat to society at local, regional, and international levels and that it has grown in scale and scope to the point where it is now able to overwhelm the integrity of local institutions and national governments through corruption, violence, and extortion. Evidence gathered from national law enforcement agencies shows that criminal enterprises generate and accumulate financial and other assets on unprecedented levels that threaten to undermine the national economies of numerous countries. Thus, anticipating the development of organized criminal activities and devising strategies to counter them is becoming a priority for governments, businesses, and citizens worldwide.
Insights from Pb Isotopes for Native Gold Formation During Hypogene and Supergene Processes at Rich Hill, Arizona

The origin of gold nuggets in placers is enigmatic as they can be mechanically separated from the primary vein deposit or can be of secondary origin, formed in the placer environment. Pb isotopes can be a valuable tracer as a match in the isotopic ratios between vein and placer gold will indicate that the placer nuggets are simply mechanically separated from the hydrothermal vein and unmodified by weathering. Reconnaissance elemental analyses revealed that vein and placer gold from the Rich Hill district, Arizona, contain up to thousands of ppm Pb and therefore both are suitable for Pb isotope analyses. We measured Pb isotopes in placer gold nuggets and compare the results to primary vein gold and sulfides and also gangue minerals and host rocks in the Rich Hill area. Primary vein gold and galena show similar Pb isotope ratios with 206Pb/204Pb ranging from 18.364 to 18.486, 207Pb/204Pb from 15.574 to 15.593, and 208Pb/204Pb from 37.150 to 37.359. This indicates that the ore metals were derived from a similar source during a hypogene hydrothermal event in the geologic past. Present-day Pb isotope compositions of local rocks in the area show distinct values compared to the primary vein mineralization. Age-corrected and modeled Pb isotope compositions for local magmatic rocks do not provide a clear picture for a possible hydrothermal ore metal source due to possible alteration processes and the long time elapsed since the mineralization event. The distinct present-day Pb isotopes in local lithological units, however, provide an excellent tracer for deciphering the origin of the placer gold. All the placer gold nuggets show very distinct Pb isotope compositions when compared to their respective hydrothermal vein source represented by the vein gold and galena. The placer gold Pb isotopes show very wide variations, with 206Pb/204Pb ranging from 17.985 to 20.057, 207Pb/204Pb from 15.494 to 15.749, and 208Pb/204Pb from 36.863 to 38.606. The placer nuggets follow the present-day Pb isotope trend observed in rocks and sediments in the area. In addition, the Pb isotopes in majority of the placer gold nuggets are far more radiogenic compared to the vein gold, sulfides, and even gangue minerals. This is indicating that a significant part, if not all, of the Pb in the placer gold was relatively recently acquired from the placer sediments. The observed distinct Pb isotope compositions between primary and placer samples suggest that gold undergoes significant chemical changes during the supergene stage. Considering a number of possible scenarios, the most plausible explanation for the observed present-day Pb isotope similarity between placer gold and local rocks is formation of a significant part of the total mass of these nuggets within the placer environment.
Modeling soil respiration based on carbon, nitrogen, and root mass across diverse Great Lake forests.

The variability in the net ecosystem exchange of carbon (NEE) is a major source of uncertainty in quantifying global carbon budget and atmospheric CO2. Soil respiration, which is a large component of NEE, could be strongly influential to NEE variability. Vegetation type, landscape position, and site history can influence soil properties and therefore drive the microbial and root production of soil CO2. This study measured soil respiration and soil chemical, biological and physical properties on various types of temperate forest stands in Northern Wisconsin (USA), which included ash elm, aspen, northern hardwood, red pine forest types, clear-cuts, and wetland edges. Soil respiration at each of the 19 locations was measured six times during 1 year from early June to mid-November. These data were combined with two additional data sets from the same landscape that represent two smaller spatial scales. Large spatial variation of soil respiration occurred within and among each forest type, which appeared to be from differences in soil moisture, root mass and the ratio of soil carbon to soil nitrogen (C:N). A soil climate driven model was developed that contained quadratic functions for root mass and the ratio of soil carbon to soil nitrogen. The data from the large range of forest types and site conditions indicated that the range of root mass and C:N on the landscape was also large, and that trends between C:N, root mass, and soil respiration were not linear as previously reported, but rather curvilinear. It
Recruitment of marine invertebrates: the role of active larval choices and early mortality

Spatial variation in the recruitment of sessile marine invertebrates with planktonic larvae may be derived from a number of sources: events within the plankton, choices made by larvae at the time of settlement, and mortality of juvenile organisms after settlement, but before a census by an observer. These sources usually are not distinguished. A study of the recruitment of four species of sessile invertebrates living on rock walls beneath a kelp canopy showed that both selection of microhabitats by settling larvae and predation by fish may be important. Two microhabitats were of interest; open, flat rock surfaces, and small pits and crevices that act as refuges from fish predators. The polychaete Spirorbis eximus and the cyclostome bryozoan Tubulipora spp. showed no preference for refuges, but settled apparently at random on the available substrata. Tubulipora was preyed upon heavily by fish, while Spirorbis was relatively unaffected. The bryozoans Celleporaria brunnea and Scrupocellaria bertholetti both recruited preferentially into refuges. Scrupocellaria were preyed upon, while Celleporaria juveniles seemed unaffected. Predation by fish modified the spatial distribution (Tubulipora), abundance (Tubulipora), or size distribution (Scrupocellaria) of the juvenile population, or had relatively little effect (Celleporaria, Spirorbis). All of the above events occur within three weeks of settlement. Since inferences about the effect of larval events on the population dynamics of adult organisms are often based on observations of the patterns of recruitment after one or two months, they are therefore likely to be misleading.
Identification of Structural Mutations in the Fifth Domain of Apolipoprotein H (β2-Glycoprotein I) Which Affect Phospholipid Binding

Apolipoprotein H (apoH), also known as beta 2-glycoprotein-I, is considered to be a cofactor for the binding of certain antiphospholipid autoantibodies to negatively charged phospholipids. Genetically determined structural abnormalities in the lipid binding domain(s) of apoH can affect its ability to bind lipid and consequently the production of the autoantibodies. In this study we have identified two common structural mutations at codons 316 and 306 in the fifth domain of apoH which rendered apoH unable to bind to negatively charged phosphatidylserine (PS). The missense mutation at codon 316 (TGG --> TCG) replaces Trp316 with Ser316 and disrupts the integrity of four highly conserved hydrophobic amino acids sequence at positions 313-316, which is a potential protein-lipid hydrophobic interaction site. The missense mutation at codon 306 (TGC --> GGC) involves the substitution of Cys306 by Gly306 which causes the disruption of a disulfide bond between Cys281 and Cys306 and affects the normal configuration of the fifth domain of apoH that appears to be critical for clustering positively charged amino acids along with four hydrophobic amino acids sequence. ApoH from the two homozygotes (Ser316/Ser316) and all seven compound heterozygotes (Ser316/Gly306) failed to bind to PS; all heterozygotes at one or the other sites and wild type showed normal PS binding. These data indicate that the fifth domain of apoH harbors the lipid binding region. An estimated 2 million Caucasians in the United States, who are compound heterozygotes for the two mutations, may be precluded from producing apoH-dependent antiphospholipid autoantibodies.
Allografts of CNS tissue possess a blood-brain barrier: III. Neuropathological, methodological, and immunological considerations.

Development of a blood-brain barrier (BBB) within mammalian CNS grafts, placed either intracerebrally or peripherally, has been controversial. Published data from this laboratory have emphasized the presence or the absence of a BBB within solid mammalian tissue or cell suspension grafts is determined intrinsically by the graft and not by the surrounding host parenchyma (e.g., brain, kidney, testis, etc.). Nevertheless, correctly interpreting whether or not a BBB exists within brain grafts is manifested by methodologies employed to answer the question and by ensuing neuropathological and immunological consequences of intracerebral grafting. The present study addresses these issues and suggests misinterpretation for the absence of a BBB in brain grafts can be attributed to: (1) rupture of interendothelial tight junctional complexes in vessels of CNS grafts fixed by perfusion of the host; (2) damage to host vessels and BBB during the intracerebral grafting procedure; (3) graft placement in proximity to inherently permeable vessels (e.g., CNS sites lying outside the BBB) supplying the subarachnoid space/pial surface and circumventricular organs such as the median eminence, area postrema, and choroid plexus; and (4) graft rejection associated with antigen presenting cells and the host immune response. The latter is prevalent in xenogeneic grafts and exists in allogeneic grafts with donor-host mismatch in the major and/or minor histocompatibility complex. CNS grafts between non-immunosuppressed outbred donor and host rats of the same strain (e.g., Sprague Dawley or Wistar rats) can be rejected by the host; these grafts exhibit populations of immuonohistochemically identifiable major histopatibility complex class I+ and class II+ cells (microglia, macrophages, etc.) and CD4+ T-helper and CD8+ T-cytotoxic lymphocytes. PC12 cell suspension grafts placed within the CNS of non-immunosuppressed Sprague Dawley rats are rejected similarly. Donor cells from solid CNS grafts placed intracerebrally and stained immunohistochemically for donor major histocompatibility complex (MHC) class I expression are identified within the host spleen and lymph nodes; these donor MHC expressing cells may initiate the host immune response subsequent to the cells entering the general circulation through host cerebral vessels damaged during graft placement. Rapid healing of damaged cerebral vessels is stimulated with exogenously applied basic fibroblast growth factor, which may prove helpful in reducing the potential entry of donor cells to the host circulation. These results have implication clinically for the intracerebral grafting of human fetal CNS cell suspensions. © 1994 Wiley-Liss, Inc.
Evidence for a Collective Intelligence Factor in the Performance of Human Groups

Psychologists have repeatedly shown that a single statistical factor—often called “general intelligence”— emerges from the correlations among people's performance on a wide variety of cognitive tasks. But no one has systematically examined whether a similar kind of “collective intelligence” exists for groups of people. In two studies with 699 individuals, working in groups of two to five, we find converging evidence of a general collective intelligence factor that explains a group's performance on a wide variety of tasks. This “c factor” is not strongly correlated with the average or maximum individual intelligence of group members but is correlated with the average social sensitivity of group members, the equality in distribution of conversational turn-taking, and the proportion of females in the group. As research, management, and many other kinds of tasks are increasingly accomplished by groups—both those working face-to-face and "virtually"(1‐3)—it is becoming even more important to understand the determinants of group
An Independent Observation of Facultative Parthenogenesis in the Copperhead (Agkistrodon contortrix)

Abstract Among reptiles, reproduction in the absence of males is often assumed to result from long-term sperm storage. Through the application of molecular genetic tools, biologists are beginning to recognize that facultative parthenogenesis can also explain such reproductive events in snakes. We observed a Copperhead (Agkistrodon contortrix) give birth to a stillborn neonate and four infertile ova after 9 yr in isolation from male snakes. To test the hypothesis that the neonate was produced asexually, we screened a panel of 10 microsatellite loci to genotype the mother and her offspring, as well as wild-caught individuals in the mother's population of origin, to assess the probability of paternity. Confirming prior research on Copperheads that suggests parthenogenesis by terminal fusion automixis, we found that four heterozygous maternal loci were homozygous in the neonate. We calculated the probability of a random male from the population as a sire to the neonate to be 2.32 × 10−13 by using the populati...
The application of the yeast N-acetyltransferase MPR1 gene and the proline analogue L-azetidine-2-carboxylic acid as a selectable marker system for plant transformation

The yeast N-acetyltransferase MPR1 gene has previously been shown to confer resistance to the toxic proline analogue azetidine-2-carboxylic acid (A2C) in yeast and transgenic tobacco. Here experiments were carried out to determine if MPR1 and A2C can work as a selectable marker system for plant transformation. The MPR1 gene was inserted into a binary vector under the control of the cauliflower mosaic virus 35S promoter and nopaline synthase terminator, and transformed into tobacco via the Agrobacterium tumefaciens-mediated leaf disc method. A2C was applied in the selection medium to select for putative transformants. PCR analysis showed that 28.4% and 66.7% of the plantlets selected by 250 muM and 300 muM A2C were positive for the MPR1 gene, respectively. Southern and northern blot analysis and enzyme activity assay confirmed the stable gene incorporation, transcription, and translation of the MPR1 transgene in the transgenic plants. The transgene-carrying T(1) progeny could be distinguished from the recessive progeny when grown on 400, 450, or 500 muM A2C. Examination of the metabolism of 22 transgenic plants by gas chromatography-mass spectrometry profiling did not reveal any significant changes. In conclusion, the results demonstrate that MPR1/A2C is a safe and efficient selection system that does not involve microbial antibiotic or herbicide resistance genes. Recent studies showed that MPR1 can protect yeast against oxidative stresses by decreasing the accumulation of the proline catabolite Delta(1)-pyrroline-5-carboxylate (P5C). However, H(2)O(2) treatment resulted in contradictory responses among the five transgenic lines tested. Further experiments are required to assess the response of MPR1 transgenic plants under oxidative stress.
Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also resensitize multidrug-resistant strains of bacteria to the effects of conventional antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii.
The 2001 Asian dust events: Transport and impact on surface aerosol concentrations in the U.S.

A transport event in April 2001 brought substantial quantities of mineral dust from Asian deserts to the U.S. atmospheric boundary layer (ABL). The dust was seen in large amounts throughout the ABL in the U.S., with almost no reduction in concentrations. It was estimated that the amount of Asian dust in the continental U.S. ABL in mid-April 2001 was 1.1 E5 metric tons, a value comparable to the daily emission flux of all U.S. sources of particulate matter (PM) less then 10 μm diameter (PM 10). In some regions, the Asian dust, combined with local pollution, elevated urban PM to levels associated with adverse health effects. The April 2001 event appears to be the largest Asian dust event ever observed in the U.S., and its effects provide evidence that air pollution issues must be viewed in a global context.
A wireless and batteryless 130mg 300µW 10b implantable blood-pressure-sensing microsystem for real-time genetically engineered mice monitoring

Genetic engineering of mice DNA sequences, together with in vivo real-time blood pressure measurement is crucial for identifying an animal's genetic variation susceptibility to cardiovascular-related diseases. However, there is no adequate solution for long-term in vivo blood pressure monitoring to date. Due to the small size of laboratory mice, a miniature, light-weight, wireless, batteryless, implantable microsystem is highly critical to capture accurate biological signals from an untethered animal in its natural habitat, thus eliminating stress and post-implant trauma-induced information distortion. Furthermore, miniaturization of a packaged system is essential for interfacing with a mouse's arteries, which exhibit a small diameter of only 200em, and is crucial for achieving a reliable sensor-artery contact for accurate measurement. The small artery renders intra-vascular stent-based blood-pressure-sensing techniques infeasible. Remote RF powering has been widely used for biomedical implants [1,2]. However, the proposed microsystem is implanted in a freely moving laboratory mouse, thus resulting in continuously changing magnetic coupling, which demands adaptive control for RF powering.
Computer Networks in the Soviet Scientific Community

Computer networks are offering scientists a host a new capabilities ranging from access to remote resources and databases to enhanced communications through electronic mail. Although networking has traditionally been one of the weakest areas of Soviet computer science [1], a number of local area networks at research institutes and the first part of a nationwide packet switching network for the Academy of Sciences have now been established. Along with surveying the achievements in these areas, this paper examines the influence of two base networking technologies, data transmission media and computers, on the development of networks. Only the non-military sphere is considered.
Long-term changes in light scattering in Chesapeake Bay inferred from Secchi depth, light attenuation, and remote sensing measurements

The relationship between the Secchi depth (Z(sub SD)) and the diffuse attenuation coefficient for photosynthetically active radiation (K(sub d)(PAR)), and in particular the product of the two, Z(sub SD) X K(sub d)(PAR), is governed primarily by the ratio of light scattering to absorption. We analyzed measurements of Z(sub SD) and K(sub d)(PAR) at main stem stations in Chesapeake Bay and found that the Z(sub SD) X K(sub d)(PAR) product has declined at rates varying from 0.020 to 0.033 /yr over the 17 to 25 years of measurement, implying that there has been a long -term increase in the scattering-to-absorption ratio. Remote sensing reflectance at the green wavelength most relevant to Z(sub SD) and K(sub d)(PAR) in these waters, R(sub rs)(555), did not exhibit an increasing trend over the 10 years of available measurements. To reconcile the observations we constructed a bio-optical model to calculate Z(sub SD), K(sub d)(PAR), Z(sub SD) X K(sub d)(PAR), and R(sub rs)(555) as a function of light attenuating substances and their mass-specific absorption and scattering coefficients. When simulations were based exclusively on changes in concentrations of light attenuating substances, a declining trend in Z(sub SD) E K(sub d) entailed an increasing trend in R(sub rs)(555), contrary to observations. To simulate both decreasing Z(sub SD) X K(sub d)(PAR) and stationary R(sub rs)(555), it was necessary to allow for a declining trend in the ratio of backscattering to total scattering. Within our simulations, this was accomplished by increasing the relative proportion of organic detritus with high mass-specific scattering and low backscattering ratio. An alternative explanation not explicitly modeled is an increasing tendency for the particulate matter to occur in large aggregates. Data to discriminate between these alternatives are not available.
Successful Use of Facilitated Communication With an Oral Child

A 6 1/2-year-old child's oral and spelled utterances were compared over a 3-month period as he was trained to use Facilitated Communication (FC), a method of augmentative and alternative communication. The child's language with FC was significantly better than his oral language in length of utterances, novelty of utterances, and syntactic complexity. His language with FC also contained more function words and over time was more intelligible and required less verbal scaffolding than his oral communication. Evidence that he was authoring his own messages during his facilitated spelling was found in his idiosyncratic use of language and his ability to convey verifiable information that was unknown to the facilitator. The strongest evidence came later with his ability to type messages without physical support. The results suggest the potential for using FC with children who have some functional oral skills but cannot express themselves fully in the oral modality. The method can serve as a means of investigating language potential and as a transition to literacy and independent typed communication.
Challenges and surprises that arise with nucleic acids during model building and refinement

The process of building and refining crystal structures of nucleic acids, although similar to that for proteins, has some peculiarities that give rise to both various complications and various benefits. Although conventional isomorphous replacement phasing techniques are typically used to generate an experimental electron-density map for the purposes of determining novel nucleic acid structures, it is also possible to couple the phasing and model-building steps to permit the solution of complex and novel RNA three-dimensional structures without the need for conventional heavy-atom phasing approaches.
Optimal dual-mode hybrid electric vehicle powertrain architecture design for a variety of loading scenarios

A hybrid-electric vehicle powertrain architecture consists of single or multiple driving modes, i.e., connection arrangements among engine, motors and vehicle output shaft that determine distribution of power. While most architecture development work to date has focused primarily on passenger cars, interest has been growing in exploring architectures for special-purpose vehicles such as vans or trucks for civilian and military applications, whose weights or payloads can vary significantly during operations. Previous findings show that the optimal architecture can be sensitive to vehicle weight. In this paper we investigate architecture design under a distribution of vehicle weights, using a simulation-based design optimization strategy with nested supervisory optimal control and accounting for powertrain complexity. Results show that an architecture under a single load has significant differences and lower fuel efficiency than an architecture designed to work under a variety of loading scenarios.
Enhancing the Ave Maria in the Ars Antiqua

The Ave Maria remains the most widely repeated prayer in Christian devotional life, and music has played a critical role in its formation and propagation. This article reviews the essential contribution of music in the dissemination of texts based on the original verses from the gospel of Luke, with new evidence concerning the tradition of affixing a petition to the core devotion. While the Ave Maria remained unfixed in form and function until the sixteenth century, this article presents three significant examples from the corpus of Ars Antiqua polyphony in which versions of the text that include both the biblical verses and a supplicatory conclusion are not only used, but are also emphasised through polyphonic techniques.
Highly-available application integration

Many applications such as e-commerce and electronic banking services are becoming very popular and needed for many of the daily functions. One of the main success factors of these services is their continuous availability. These services must be available without interruptions 24-hours a day 7-days a week. Most of these applications require integration with legacy systems. However, many of these legacy systems were designed to provide their services during specified periods of the day and suspend for the rest of the day for different reasons such as performing data backups and end-of-day processing. This paper proposes reliable and efficient middleware-based methods to increase the availability of integrations with legacy applications. Some methods utilizing concurrent processing and database replication are suggested to solve the scheduled legacy applications unavailability. This paper discusses the problem in details and described the proposed solution for the case of electronic banking. A real-life implementation of the proposed solution was implemented at a bank resulting in the availability of the banking services being increased significantly.
Wind speed response of marine non-precipitating stratocumulus clouds over a diurnal cycle in cloud-system resolving simulations

Abstract. Observed and projected trends in large-scale wind speed over the oceans prompt the question: how do marine stratocumulus clouds and their radiative properties respond to changes in large-scale wind speed? Wind speed drives the surface fluxes of sensible heat, moisture, and momentum and thereby acts on cloud liquid water path (LWP) and cloud radiative properties. We present an investigation of the dynamical response of non-precipitating, overcast marine stratocumulus clouds to different wind speeds over the course of a diurnal cycle, all else equal. In cloud-system resolving simulations, we find that higher wind speed leads to faster boundary layer growth and stronger entrainment. The dynamical driver is enhanced buoyant production of turbulence kinetic energy (TKE) from latent heat release in cloud updrafts. LWP is enhanced during the night and in the morning at higher wind speed, and more strongly suppressed later in the day. Wind speed hence accentuates the diurnal LWP cycle by expanding the morning–afternoon contrast. The higher LWP at higher wind speed does not, however, enhance cloud top cooling because in clouds with LWP ⪆ 50 g m−2, longwave emissions are insensitive to LWP. This leads to the general conclusion that in sufficiently thick stratocumulus clouds, additional boundary layer growth and entrainment due to a boundary layer moistening arises by stronger production of TKE from latent heat release in cloud updrafts, rather than from enhanced longwave cooling. We find that large-scale wind modulates boundary layer decoupling. At nighttime and at low wind speed during daytime, it enhances decoupling in part by faster boundary layer growth and stronger entrainment and in part because shear from large-scale wind in the sub-cloud layer hinders vertical moisture transport between the surface and cloud base. With increasing wind speed, however, in decoupled daytime conditions, shear-driven circulation due to large-scale wind takes over from buoyancy-driven circulation in transporting moisture from the surface to cloud base and thereby reduces decoupling and helps maintain LWP. The total (shortwave + longwave) cloud radiative effect (CRE) responds to changes in LWP and cloud fraction, and higher wind speed translates to a stronger diurnally averaged total CRE. However, the sensitivity of the diurnally averaged total CRE to wind speed decreases with increasing wind speed.
Storm-induced Redistribution of Deepwater Sediments in Lake Ontario

ABSTRACT High-resolution seismic reflection profiles, side-scan sonar profiles, and surface sediment analyses for grain size (% sand, silt & clay), total organic carbon content, and carbonate content along shore-perpendicular transects offshore of Olcott and Rochester in Lake Ontario were utilized to investigate cm-thick sands or absence of deepwater postglacial sediments in water depths of 130 to 165 m. These deepwater sands were observed as each transect approached and occupied the “sills,” identified by earlier researchers, between the three deepest basins of the lake. The results reveal thin (0 to 5-cm) postglacial sediments, lake floor lineations, and sand-rich, organic, and carbonate poor sediments at the deepwater sites (> 130 m) along both transects at depths significantly below wave base, epilimnetic currents, and internal wave activity. These sediments are anomalous compared to shallower sediments observed in this study and deeper sediments reported by earlier research, and are interpreted to in...
Bronchial circulatory reversal of methacholine-induced airway constriction

Although a role for the bronchial circulation in clearance of bronchoactive agents has been frequently proposed, experimental evidence is limited. In this study, we determined the importance of bronchial blood flow (QBA) in the recovery from methacholine-(MCh) induced bronchoconstriction. In 10 pentobarbital-anesthetized ventilated sheep, the bronchial branch of the bronchoesophageal artery was cannulated and perfused (0.7 ml.min-1.kg-1) with blood pumped from the femoral artery. MCh was infused directly into the bronchial artery at increasing concentrations (10(-7) to 10(-5) M). MCh infusion caused a concentration-dependent increase in airway resistance at constant QBA. However, the time constant of recovery (TC) from airway constriction after cessation of the MCh infusion was not dependent on the MCh concentration or the magnitude of the increases in airway resistance. When QBA was at 50, 100, and 200% of control level, with constant MCh concentration, TC was 44 +/- 6, 25 +/- 2, and 24 +/- 2 (SE) s at each flow level, respectively. TC at 50% of control QBA was significantly greater than at control QBA (P less than 0.01). Thus the magnitude of QBA can alter the time course of recovery from MCh-induced increases in airway resistance. These results document the importance of QBA in reversing agonist-induced constriction and suggest that an impaired bronchial circulation may contribute to the mechanism of airway hyperreactivity.
Teaching "Lawfulness" With Kodu

This paper introduces reasoning about lawful behavior as an important computational thinking skill and provides examples from a novel introductory programming curriculum using Microsoft's Kodu Game Lab. We present an analysis of assessment data showing that rising 5th and 6th graders can understand the lawfulness of Kodu programs. We also discuss some misconceptions students may develop about Kodu, their causes, and potential remedies.
Electronic Structure and Properties of Organic Bulk-Heterojunction Interfaces

The electronic structure and physical mechanisms of carrier generation and transport in the organic bulk heterojunction are reviewed. The electronic structure describes the bands and band-tail states, the band alignment at the bulk-heterojunction interface, and the overall density-of-states model. The different electronic character of excitons and mobile charge is discussed, the former being highly molecular and the latter more delocalized. Dissociation of the exciton via the charge-transfer (CT) states is attributed to weak binding of the CT state arising from charge delocalization. Carrier transport and charge collection is strongly influenced by the presence of localized band-tail states. Recombination is attributed primarily to transitions from mobile carriers to band-tail or deep trap states.
Physician Impressions of Physical Therapist Practice in the Emergency Department: Descriptive, Comparative Analysis Over Time.

Background Emergency department (ED) use in the United States is expected to rapidly increase. Nearly half of all ED visits are classified as semiurgent or nonurgent, and many fall into the musculoskeletal category. Despite growing international evidence that patients are appropriately and safely managed by ED physical therapists in a time-efficient manner, physical therapist practice in EDs is not widely understood or utilized in the United States. To date, no studies have reported the impressions of ED physicians about this practice. Objectives The purposes of this study were: (1) to assess ED physicians' impressions of ED physical therapist practice 2 years after practice was initiated and (2) to determine whether physicians' impressions changed 7 years later. Methods All ED staff physicians and medical residents at a level I trauma hospital were invited to complete a survey in 2004 and 2011. Results In both years, a majority of physicians reported favorable impressions of ED physical therapist practice. Physical therapists were valued for educating patients about safety and injury prevention, providing appropriate gait training, assisting with disposition planning, and providing interventions as alternatives to pain medication. Many physicians supported standing physical therapist orders for certain musculoskeletal conditions. The most common concern was the additional time that patients spend in the ED for a physical therapist consult. Limitations The results of this study may not reflect the impressions of physicians in all EDs that employ physical therapists. Conclusions Emergency department physicians reported favorable impressions of ED physical therapist practice 2 years and 9 years following its implementation in this hospital. This study showed that ED physicians support standing physical therapist orders for certain musculoskeletal conditions, which suggests that direct triage to ED physical therapists for these conditions could be considered.
Dermatological manifestations of palifermin therapy: a common side effect of its use in oncology.

I read with great interest the recent article by Yazbeck et al in a recent issue of your esteemed journal. The article provides for highly interesting reading. Palifermin clearly has a definite benefit in oncology. However, its clinical use may be associated with the development of a number of dermatological side effects. For instance, Kaloyannidis et al have reported the development of mucosal hyperpigmemtation accompanied by allodynia following the clinical use of palifermin. Similarly hyperkeratosis, hyperplastic gingivitis and macroglossia may occur secondary to palifermin administration. Palifermin use may also be associated with the development of lichenoid lesions that are primarily seen in the intertriginous areas. These lesions surprisingly stain positive with antibodies to Ki-67 and show histological features similar to verruca plana. Palifermin may also trigger over expression of filaggrin resulting in the development of flexural hyper pigmentation.
Retinal regeneration following OCT-guided laser injury in zebrafish.

Purpose. Establish a focal injury/regeneration model in zebrafish using laser photocoagulation guided by optical coherence tomography (OCT).
Odd or Even? Monolayer Domain Size Depends on Diyne Position in Alkadiynylanthracenes

1,5-(Alkadiynyl)anthracenes self-assemble single component and multicomponent monolayers at the solution–HOPG interface. An alkadiynyl chain’s kinked shape constrains the molecular structures with which it can close-pack. This affords rudimentary molecular recognition that has been used to direct self-assembly of 1-D patterned, multicomponent monolayers. The unit cell building blocks of single- and multicomponent alkadiynylanthracene monolayers repeat with high fidelity for 100s of nanometers along the side chain direction. Unit cell repeat fidelity along the orthogonal, anthracene column direction of the monolayer depends on diyne location within the side chain; even-position diyne side chains produce high fidelity of unit cell repeats and wider domain widths along the anthracene columns, whereas odd-position diyne side chains produce more frequent domain interfaces that disrupt the anthracene columns. Alkadiynylanthracene monolayers may be viewed as stacks of 1-D molecular tapes. 1-D tape molecular comp...
A Note on Complex Polynomials Having Rolle's Property and the Mean Value Property for Derivatives

(1968). A Note on Complex Polynomials Having Rolle's Property and the Mean Value Property for Derivatives. Mathematics Magazine: Vol. 41, No. 3, pp. 140-144.
Research on the Application of Web Server Cluster in Open Experiment of Campus Network

University campus relies on Web technology offering experiment courses for opening experiment on the net. Web server should not only offer more application service, but also respond different requests quickly. So, this aggravated Web server's load and caused the performance bad. To solve this problem, a solution scheme adopting Web server cluster technology was discussed.
In vitro fertilization and embryo transfer as a treatment for male factor infertility

In vitro fertilization was attempted in 25 consecutive cycles as a treatment for male factor infertility. These cycles were compared with 25 control cycles in which a male factor was not present. The fertilization rates for mature oocytes in male factor cases and controls were 17% and 70%, respectively (P
Corticotropin-Releasing Factor: Central Regulation of Autonomic Nervous and Visceral Function

Behavioral and somatic responses to internal and external stimuli are attended and facilitated by appropriate alterations in endocrine and autonomic function. Transduction of sensory information into concurrent and complementary behavioral, hormonal, and visceral outputs is a primary function of the central nervous system (CNS). The neural circuitry and transmitters mediating specific components of adaptive whole-animal responses are understood in some detail whereas knowledge of CNS integrative mechanisms that coordinate differential patterns of physiological and behavioral activity is rudimentary at best. Owing to several unique features of peptide transmitters, recent attention has focused on their role in mediating CNS integrative functions.
Evolution of a policy disallowing the use of alternative therapies in a health system

The evolution of a policy disallowing patients' use of alternative therapies in a health system is described. The pharmacy and therapeutics (P&T) committee at Children's Hospital of Michigan, a part of the Detroit Medical Center (DMC), was asked to review the appropriateness of allowing inpatients to bring in and use alternative therapy products during their hospitalization. Recognizing the interest of consumers in alternative medicines and patients' growing involvement in their own care, the committee drafted a policy that allowed patients to continue taking dietary supplements after being admitted to the hospital. If the physician had no concerns about potential toxicities or drug interactions for a particular product, he or she would write a medication order allowing it to be used. Purchasing and administering the products were deemed the responsibility of the patient or the family. However, many issues concerning supplements remained unresolved, including questions about safety, efficacy, dosing, drug interactions, ethical conflicts, and liability. Ultimately, the P&T committee decided that the potential risks associated with alternative therapies outweighed potential benefits and adopted a policy disallowing the use of alternative therapies by hospitalized patients. The policy was eventually implemented at all eight DMC hospitals. A health system responded to patients' desire to continue their use of alternative therapies during hospitalization by drafting a policy allowing such use. However, concerns related to safety, efficacy, ethics, and liability led to the abandonment of the liberal policy and implementation of a highly restrictive one.
Modulatory effects of serotonin, FMRFamide, and myomodulin on the duration of action potentials, excitability, and membrane currents in tail sensory neurons of Aplysia

1. The electrophysiological properties of sensory neurons that mediate withdrawal reflexes of Aplysia can be modulated by a variety of neurotransmitters. We compared the known excitatory actions of...
Molecular design of light-harvesting photosensitizers: effect of varied linker conjugation on interfacial electron transfer.

Interfacial electron transfer dynamics of a series of photosensitizers bound to TiO2via linkers of varying conjugation strength are explored by spectroscopic and computational techniques. Injection and recombination depend on the extent of conjugation in the linker, where the LUMO delocalization determines the injection dynamics but both the HOMO and HOMO−1 are involved in recombination.
A Decade of Change: Measuring the Extent, Depth and Severity of Food Insecurity

Rates of food insecurity in the US have been rising since 2000 spiking with the onset of the Great Recession in 2008, and have remained essentially unchanged since then despite improvements in the economy. The present study employed a series of indices adapted from the poverty literature to examine the depth and severity of food insecurity across the decade by race and ethnicity among low-income households with and without children. The most rapid increases in the depth and severity of food insecurity were found among low-income households without children. Non-Hispanic White households with and without children had lower prevalence rates but steeper increases in the depth and severity of food insecurity throughout the decade. Non-Hispanic Black households with and without children were at the most disadvantaged among low-income populations.
Indoor collocation: exploring the ultralocal context

Prior research has investigated how to improve awareness of collocation at neighborhood scales or citywide through the use of smartphone apps. The availability of indoor maps and more accurate indoor navigation technologies motivate us to investigate the concept of collocation in the context of indoor settings. In this paper, we introduce the notion of ultralocality, which involves people and various kinds of resources collocated in an indoor environment. We present our interview study and initial results that help us understand how people perceive collocation in an ultralocal enviornment. We also introduce a mobile application that helps people explore an ultralocal environment in the college campus buildings.
Diagnosis and Management of Microscopic Colitis

Microscopic colitis (MC) is a relatively common cause of chronic watery diarrhea, especially in older persons. Associated symptoms, including abdominal pain and arthralgias, are common. The diagnosis is based upon characteristic histological findings in the presence of diarrhea. The two types of MC, collagenous and lymphocytic colitis, share similar clinical features, with the main difference being the presence or absence of a thickened subepithelial collagen band. There are several treatment options for patients with MC, although only budesonide has been well studied in multiple controlled clinical trials. This review will describe the clinical features, epidemiology, pathophysiology, diagnostic criteria, and treatment of patients with MC.
Transcranial Low-Level Laser (Light) Therapy for Brain Injury

Abstract Background: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI). Methods: We review the fundamental mechanisms at the cellular and molecular level and the effects on the brain are discussed. There are several contributing processes that have been proposed to lead to the beneficial effects of PBM in treating TBI such as stimulation of neurogenesis, a decrease in inflammation, and neuroprotection. Both animal and clinical trials for ischemic stroke are outlined. A number of articles have shown how transcranial LLLT (tLLLT) is effective at increasing memory, learning, and the overall neurological performance in rodent models with TBI. Results: Our laboratory has conducted three different studies on the effects of tLLLT on mice with TBI. The first studied pulsed against continuous laser irradiation, finding that 10 Hz pulsed was the best. The second compared four different wavelengths, discovering only 660 and 810...
Inference in Approximately Sparse Correlated Random Effects Probit Models With Panel Data

We propose a simple procedure based on an existing “debiased” l1-regularized method for inference of the average partial effects (APEs) in approximately sparse probit and fractional probit models w...