cssi/SciSciGPT-SciSciNet huggingface dataset:
Adhesion Regulates MAP Kinase/Ternary Complex Factor Exchange to Control a Proliferative Transcriptional Switch

Summary Background The ternary complex factors (TCFs; Elk1, Net, and Sap-1) are growth factor-responsive transcription cofactors of serum response factor (SRF) and are activated by MAP kinase (MAPK) phosphorylation to regulate immediate early gene transcription. Although cell adhesion also can regulate immediate early genes and proliferation, the mechanism for this effect has remained unexplored. Results Restricting adhesion and spreading of G 0 -synchronized cells on substrates with decreasing size of micropatterned islands of fibronectin suppressed serum-induced immediate early gene expression and S phase entry. Knockdown of Sap-1 decreased expression of the immediate early genes egr1 and fos and subsequent proliferation normally present with high adhesion, whereas knockdown of Net rescued egr1 and fos expression and proliferation normally suppressed by low adhesion. Chromatin immunoprecipitation studies showed increased occupancy of egr1 and fos promoters by Sap-1 with high adhesion, whereas low adhesion increased Net occupancy. This switch in TCF promoter binding was regulated by an adhesion-mediated switch in MAPK activity. Increasing adhesion enhanced serum-induced JNK activity while suppressing p38 activity, leading to increased Sap-1 phosphorylation and Net dephosphorylation, and switching Net with Sap-1 at egr1 and fos promoters to support proliferation. Microarray studies confirmed this switch in TCF regulation of proliferative genes and uncovered novel gene targets and functions coregulated by Sap-1 and Net. Conclusions These data demonstrate a key role for the TCFs in adhesion-induced transcription and proliferation and reveal a novel MAPK/TCF transcriptional switch that controls this process.
The doctor's political body: Doctor–patient interactions and sociopolitical belonging in Venezuelan state clinics

Patients of Venezuelan state clinics ascribe meanings to doctor–patient interactions that reverberate beyond the immediacy of the clinical encounter to shape political subjectivities. They seek not just medical goods and services from clinical interactions but also expressions of recognition, respect, care, and solidarity from doctors. I argue that patients who had long resented what they saw as the Venezuelan state's broken promises to use national oil wealth to provide for its citizens now read its efforts to address sociopolitical inequalities in the bodily dispositions of its medical workers. Combining anthropological approaches to doctor–patient interactions and to medical embodiment, I show how doctors’ embodied practices can render biomedical encounters politically significant for patients, activating or foreclosing a sense of sociopolitical belonging. In doing so, I demonstrate how sociopolitical orders are constructed and challenged through the intimacies of biomedical practice.
Left atrial hybrid closure of muscular ventricular septal defects with the Amplatzer device

Muscular ventricular septal defects (mVSDs), whether dealt with as a single lesion or as a complex of congenital heart disease, are fraught with difficulty. Pulmonary artery bands are palliative, and ventriculotomies initiate scarring. Simple single mVSDs are difficult to visualize from a right atrial approach because they are commonly in the apex, whereas multiple mVSDs have muscular septations within the right ventricular cavity, making it difficult to visualize a defined edge for optimal patch opposition, leaving residual shunts. Transcatheter occluders have been placed in the ventricular septum percutaneously, perventricularly, and intraoperatively. In general, a significant amount of experience and resources are necessary to perfect the percutaneous/perventricular techniques, whereas the direct intraoperative approach is more straightforward. Furthermore, cardiopulmonary bypass (CPB) is often necessary for other associated complex congenital lesions. We present a simple hybrid-type approach to close mVSDs during cardioplegic arrest using an Amplatzer duct occluders (AGA Medical, Golden Valley, Minn) through the left atrium in a patient with D-transposition of the great arteries.
Specifying the Role of Exposure to Violence and Violent Behavior on Initiation of Gun Carrying: A Longitudinal Test of Three Models of Youth Gun Carrying

Two waves of longitudinal data from 1,049 African American youth living in extreme poverty are used to examine the impact of exposure to violence (Time 1) and violent behavior (Time 1) on first time gun carrying (Time 2). Multivariate logistic regression results indicate that (a) violent behavior (Time 1) increased the likelihood of initiation of gun carrying (Time 2) by 76% after controlling for exposure to violence at Time 1, which is consistent with the stepping stone model of youth gun carrying, and (b) youth who were both exposed to violence at Time 1 and engaged in violent behavior at Time 1 were more than 2.5 times more likely to initiate gun carrying at Time 2 compared to youth who had neither of these characteristics, which supports the cumulative risk model of youth gun carrying. The authors discuss the implications of these findings in clarifying the role of violence in the community on youth gun carrying and the primary prevention of youth gun violence.
Loaded transmission line as a two-port network

A college homework problem, dealing with a loaded transmission line, is reviewed. The setup is then treated as a two-port distributed network. The law of conservation of power is explained with the aid of a scattering theory. Two coupled circuit relations are then formulated. One, associated with the load terminals, is quite different from the conventional equation involving the self impedance and the mutual impedance. An effective impedance function, designated as the scattering impedance, is introduced to facilitate the formulation. The result of applying the Rayleigh/Carson reciprocity theorem to find the expression of the load current is also discussed.
Band-Restricted Estimation of Noise Variance in Filtered Backprojection Reconstructions Using Repeated Scans

We introduce a new estimator for noise variance in tomographic images reconstructed using algorithms of the filtered backprojection type. The new estimator operates on data acquired from repeated scans of the object under examination, is unbiased, and is shown to have significantly lower variance than the conventional unbiased estimator for many scenarios of practical interest. We provide an extensive theoretical analysis of this estimator, highlighting the circumstances under which it is most effective. This analysis includes both general and specific data-correlation patterns. Moreover, we have applied our estimator to real X-ray computed tomography data and present preliminary results that support the theory and provide experimental evidence of the new estimator's efficacy.
Confidentiality Agreements and Scientific Independence

minated. Confidentiality agreements of the type I signed are routinely signed by visiting vendors, industrial consultants, and purchasers. Such agreements cover trade secrets and confidential production details and have never been construed to limit the reporting of occupational disease. In a recent survey conducted by the Association of Occupational and Environmental Clinics (AOEC), all 11 respondents who reported ever having been asked to sign such agreements at the time of plant visits with medical students indicated that they do so without obtaining legal clearance from their universities. More than a dozen lawyers and legal scholars have concluded that the signed agreement is irrelevant to the issues at hand. Before agreeing to serve as the company’s consultant, I explained that it would be necessary for our Operating Principles and Guidelines to be signed by management and posted at the plant. This document notes that as responsible members of the academic and public health community, we may find it important to report or publish scientific articles based on our findings. The company’s management orally agreed in principle with these terms but reserved the right to have its legal counsel review the details. Over the subsequent weeks, the company’s executive vice-president repeatedly assured. both me and our program’s industrial hygienist of his intent to sign and post the document, a fact that our industrial hygienist has attested to in a notarized statement to the federal government. Moreover, at each of five employee educational sessions that either the company’s CEO or its vice-president attended, I described and displayed our Operating Principles and explained that the company would be signing and posting them. At a subsequent meeting with the company’s vice-president, we were informed that the company was ready to sign and post the document if we would make a few changes requested by legal counsel. After some discussion, we agreed on the final wording. When I expressed my willingness to redo the document and return it for posting, I was informed that company personnel would make the changes. Four weeks later, still
Butyricimonas virosa bacteraemia identified by MALDI-TOF.

We read with interest the recent report by Ulger Toprak et al. [1] reporting the first case of Butyricimonas virosa bacteraemia published earlier this year. Here we describe the case of a 72-year-old man with colon cancer who presented with septic shock after aortic aneurysm surgery, with Butyricimonas virosa recovered from blood cultures. This anaerobic bacteria and related species had been previously described in rat and human faecal material [2], [3] but never before in an infectious context in humans. The authors point out that this Gram-negative anaerobic bacterium produced catalase, was inhibited on Bacteroides bile aesculin agar and was resistant to kanamycin (1 mg), vancomycin (5 μg) and colistin sulfate (10 μg). This phenotypic features were suggestive of a Prevotella spp. However, 16S rRNA sequencing demonstrated a 99% nucleotide identity with B. virosa [1]. Recently we also identified a case of B. virosa bacteraemia in a 81-year-old male veteran who developed a fever 18 days after a Whipple procedure for adenocarcinoma of the duodenum. Two sets of blood samples were drawn for culture. Gram-negative rods were isolated from the anaerobic blood culture bottle of one set during the fifth day of incubation, after masked subculture of a blood culture bottle triggering positive with a negative Gram stain. Consistent with the report of Ulger Toprak et al. [1], our isolate grew anaerobically on Brucella blood agar (Becton Dickinson, Franklin Lakes, NJ, USA), and on Gram stain appeared as a small Gram-negative rod. Our isolate was catalase positive and was resistant to kanamycin (1 mg), vancomycin (5 μg) and colistin sulfate (10 μg). Utilizing RapID Ana testing (bioMerieux, Marcy l’Etoile, France), the isolate was found to be positive for β-galactosidase, N-acetyl-β-glucosaminidase, indole, leucyl glycine and pyroglutamic acid arylamidase, as was the previously reported isolate; however, a conclusive identification could not be made. The isolate was then evaluated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) (MicroFlex LT; Bruker Daltonics, Leipzig, Germany) with and without a formic acid extraction. Vitek MS identified three separate colonies of the bacterium as Butyricimonas virosa (score = 2.531, MALDI Biotyper 3.1). Our patient recovered without antimicrobial treatment. Molecular identification technologies such as 16S rRNA sequencing and MALDI-TOF provide microbiologists with a much richer understanding of clinical anaerobic bacteriology. Without MALDI-TOF, we would not have correctly identified this organism. Proper identification of significant isolates may help to better define the relationships between particular pathogens and clinical syndromes.
Full Employment on Trial: A Case Study of British Experience

British post-war experience constitutes the best case yet available for study of a conscious government policy of combining full employment and price stability within the framework of free collective bargaining. In this paper, a few of the unresolved problems inherent in a full-employment economy are examined in the light of British experience. The hard core of the problem of full-employment price instability is the difficulty of restraining demands for higher wages, not because labour is less “responsible” than other sectors of the economy, but because wages constitute the largest single item both of costs and of income. It is therefore interesting to determine whether British governments have produced a wage policy which could compress wage demands within the limits say, of the productivity of labour. Has any principle (other than uninhibited self-interest) provided a new orientation to the process of collective bargaining? Has collective bargaining with a fully employed labour force in Britain disturbed the traditional constancy of distributive shares to capital and labour and if so, what was the impact of this, in turn, on economic reconstruction? What, in general, has been the rationale of trade unions in the environment of full employment? Britain has attempted to discover answers to these problems. Only by knowing these answers can we intelligently appraise the policy of maintaining full employment.
On Historical Exhaustion: Argentine Critique in an Era of “Total Corruption”

This essay examines the experience of corruption as an unavoidable and self-destructive dynamic of everyday life in post-crisis Argentina. Embedded in both everyday practices and popular evaluations of those practices, corruption in this context of neoliberal crisis operated as a folk category of socio-moral critique much like witchcraft does in some other settings, for it named a cannibalistic logic that imperiled the very framework of sociality. In order to grasp the reflexive pragmatics of this category, the essay attends first to the conceptual, then to the ethnographic, and finally to the historical dimensions of its practical life. Moving across these three dimensions, it argues that corruption indexed a very particular moral sensibility, marked by the sense of exhausted historical possibilities and inevitable national crisis.
Isotopomer-selective spectra of a single intact H2O molecule in the Cs(+)(D2O)5H2O isotopologue: Going beyond pattern recognition to harvest the structural information encoded in vibrational spectra.

We report the vibrational signatures of a single H2O molecule occupying distinct sites of the hydration network in the Cs+(H2O)6 cluster. This is accomplished using isotopomer-selective IR-IR hole-burning on the Cs+(D2O)5(H2O) clusters formed by gas-phase exchange of a single, intact H2O molecule for D2O in the Cs+(D2O)6 ion. The OH stretching pattern of the Cs+(H2O)6 isotopologue is accurately recovered by superposition of the isotopomer spectra, thus establishing that the H2O incorporation is random and that the OH stretching manifold is largely due to contributions from decoupled water molecules. This behavior enables a powerful new way to extract structural information from vibrational spectra of size-selected clusters by explicitly identifying the local environments responsible for specific infrared features. The Cs+(H2O)6 structure was unambiguously assigned to the 4.1.1 isomer (a homodromic water tetramer with two additional flanking water molecules) from the fact that its computed IR spectrum matches the observed overall pattern and recovers the embedded correlations in the two OH stretching bands of the water molecule in the Cs+(D2O)5(H2O) isotopomers. The 4.1.1 isomer is the lowest in energy among other candidate networks at advanced (e.g., CCSD(T)) levels of theoretical treatment after corrections for (anharmonic) zero-point energy. With the structure in hand, we then explore the mechanical origin of the various band locations using a local electric field formalism. This approach promises to provide a transferrable scheme for the prediction of the OH stretching fundamentals displayed by water networks in close proximity to solute ions.
Relationship between numbers of face flies (Diptera: Muscidae) and nearest-neighbor distance among Holstein cows.

The relationship between numbers of face flies, Musca autumnalis De Geer, and aggregation among Holstein cows was examined by counting face flies and rating the nearest-neighbor distance for 12 to 16 cows in each of seven herds three times per day over 10-day periods. Average fly counts and distances to nearest neighbor for each cow were ranked on a within-herd basis and examined for correlation with each other, and with sample time, cow face color, age, weight, freshening date, and milk volume. The results show that within-herd rank for average numbers of face flies per face was consistently correlated between successive observations, which indicates that the relative numbers of face flies carried by cows were consistent within days. In addition, average numbers of face flies per face were inversely correlated with nearest-neighbor distance, which also remained constant through time. Thus certain cows were consistently in close proximity to other cows, and these animals hosted fewer face flies than did their consistently more dispersed herd mates. Multiple regression analysis showed that average numbers of face flies per face were correlated, in decreasing order, with nearest-neighbor distance, cowage, weight, freshening date, and milk volume; host face color was unrelated.
Increasing secondary and renewable material use: a chance constrained modeling approach to manage feedstock quality variation.

The increased use of secondary (i.e., recycled) and renewable resources will likely be key toward achieving sustainable materials use. Unfortunately, these strategies share a common barrier to economical implementation − increased quality variation compared to their primary and synthetic counterparts. Current deterministic process-planning models overestimate the economic impact of this increased variation. This paper shows that for a range of industries from biomaterials to inorganics, managing variation through a chance-constrained (CC) model enables increased use of such variable raw materials, or heterogeneous feedstocks (hF), over conventional, deterministic models. An abstract, analytical model and a quantitative model applied to an industrial case of aluminum recycling were used to explore the limits and benefits of the CC formulation. The results indicate that the CC solution can reduce cost and increase potential hF use across a broad range of production conditions through raw materials diversifi...
Food intake and temperature stress in the monkey.

SummaryFour monkeys were maintained at a control temperature of 25° ambient and tested at environmental temperatures of 34, 38, 8, and 15° for periods ranging from 5 to 7 days with food and water intake as the dependent variables. The results showed an inverted U-shaped curve for food intake; as ambient temperature was raised or lowered from 25° the food intake declined. Water intake was directly related to ambient temperature.
Audio Explanations to Enhance Statistical Understanding: A Case Study in Introductory Statistics

This paper reports on the experience of using audio explanations as part of homework solutions in two introductory statistics courses. Two example problems are given which utilise audio to help students in their statistical understanding. An explanation of how to insert audio into a .docx or .pdf file is also included.
Congressional Voting in the 1920s: A Test of Urban-Rural Conflict

In the 1950s, historians explained many phenomena of the 1920s as products of conflicts between urban and rural areas. The Ku Klux Klan, Fundamentalism, Prohibition, immigration restriction, and Al Smith's defeat in the presidential election of 1928 were understood as examples of urban-rural tensions. More recent scholars have found evidence to challenge the urban-rural thesis by examining election results, state legislative voting, Klan membership, and support for Prohibition and Fundamentalism.1 Before scholars reject the urban-rural interpretation, however, it can be tested in a new way: analysis of roll-call voting in the House of Representatives in the 1920s. Such an analysis assumes that the intrinsic and symbolic importance of certain issues to urban or rural legislators outweighs other factors (friendship, partisanship, and pressures from House leaders, the president, and special interests) in determining voting patterns. For a more precise refinement of the urban and rural classifications, congressional voting of representatives from metropolitan districts and extremely rural ones will be compared. The urban-rural (and metro-most rural) divisions cannot be perfect and complete, but differences in voting should be observable if the urban-rural thesis is valid. Not all issues of the 1920s can be examined through roll calls; many did not come before Congress for a vote. On two questions central to the urban-rural interpretation, howeverProhibition and immigration restriction Congress did act. Four votes on each will be considered. Two roll-call votes on immigration restriction involved voting first to approve an amendment to a bill to reduce the suspension of all immigration from two years to just fourteen months, and second, to pass the bill. Four years later the House accepted an amendment to another bill to limit the burden of proof required of aliens to stay in the country, and then it approved the bill itself that restricted immigration to 2 percent of the 1890 population. In both 1920 and 1924, opponents of immigration restriction would have supported
Ground Testing of Active Thermal Tiles

The Active Thermal Tiles experiment explores another option for managing heat onboard spacecraft. The Active Thermal Tiles (ATTs) are thermoelectric devices that can alter the thermal gradient between the bus and payload without any fluids or moving parts. This makes them ideal for use in spacecraft. The ground unit was tested in a vacuum chamber under 84 different conditions between 280K and 310K. The power supplied to the payload was varied between 0.0A and 3.0A. Conductance and the coefficient of performance were measured and a performance map was created. In addition, the energy used by the ATTs was compared against the energy used by survival heaters.
A NOVEL BONDING PROCESS:SUPER-COOLED TRANSIENT LIQUID PHASE BONDING

A novel super-cooled process for transient liquid phase(TLP)bonding was proposed, which is different from conventional TLP bonding in the following:the liquid interlayer(Fe-Ni base amorphous alloy)is treated at a high temperature for a few seconds,and then at a low temperature for a few minutes,both two temperatures are higher than its melting point.Owing to a fall of temperature, a super-cooling of composition is formed at the liquid/solid interface and the interfacial stabilities of the equilibrium solidification is broken,resulting in a cellular interface.After the completion of solidification,the interface disappeared,and a seamless joint is produced.The experiment of the novel super-cooled process was carried out using carbon steel as base metal and iron-nickel base amorphous alloy as interlayer,and compared with that of conventional TLP bonding.A non-planar interface formed at the first stage and disappeared at the finally stage during super-cooled bonding, so a homogenous joint without interface was obtained.As the detrimental effect of interface on bond properties is avoided,the impact toughness of joint is improved,which reached the base metal level.
Individual Differences in Infant Cognition: Methods, Measures, and Models

Publisher Summary This chapter evaluates and interprets the results of studies on the effects of early fatty acid nutrition on developmental outcome. In infant-control procedures, the duration and the decrement reflect one important underlying cognitive process, recovery another, with trials to criterion and habituation pattern each reflecting separate processes that may or may not be cognitive in nature. There appears to be significant prediction of later cognition from measures of infant attention and memory. The persistence of the prediction phenomenon across new samples raises confidence in the utility of these measures, even if they account for a relatively modest proportion of the variance in later cognitive status. The modest reliability of the infant measures, most likely, serves as a significant constraint on the magnitude of this prediction. It is suggested that the measurement of infant attention, encoding, and memory in isolation ignores the obvious and powerful contributions that the environment makes to any child's cognitive status.
Endocrinological Studies Relating to Trophoblastic Disease in Man

Mammalian trophoblast is among the very earliest tissues to differentiate during ontogenetic development. It is therefore of singular significance that trophoblastic cells in several primate species are known to produce hormones. We shall be concerned here only with those hormonally active substances known to be produced by tumors containing trophoblastic elements. Such hormone-producing trophoblastic tumors have been identified with regularity and certainty only in man. Scattered cases of choriocarcinoma in the dog are reported in the veterinary literature, but the hormonal activity of such rare canine tumors has not been clearly established. The teratoid testicular tumors of mice described by Stevens and Little (1954) apparently are not hormone-producing.
Happiness as an intrinsic motivator in reinforcement learning

Reinforcement learning, a general and universally useful framework for learning from experience, has been broadly recognized as a critically important concept for understanding and shaping adaptive behavior, both in ethology and in artificial intelligence. A key component in reinforcement learning is the reward function, which, according to an emerging consensus, should be intrinsic to the learning agent and a matter of appraisal rather than a simple reflection of external outcomes. We describe an approach to intrinsically motivated reinforcement learning that involves various aspects of happiness, operationalized as dynamic estimates of well-being. In four experiments, in which simulated agents learned to explore and forage in simulated environments, we show that agents whose reward function properly balances momentary hedonic and longer-term eudaimonic well-being outperform agents equipped with standard fitness-oriented reward functions. Our findings suggest that happiness-based features can be useful in developing robust, general-purpose reward mechanisms for intrinsically motivated autonomous agents.
Providers’ time spent and tools used when discussing the HPV vaccine with parents of adolescents

Abstract Objectives Little is known about HPV vaccine communication tools currently used by primary care providers of adolescents, or how such tools impact the quality of HPV vaccine recommendations, which some have defined as using a “presumptive” communication style, continuing to offer vaccines despite resistance, and strongly recommending vaccines at the appropriate ages. We surveyed primary care providers to assess their current use of HPV vaccine communication tools, and how these related to their HPV vaccine recommendation quality. Study Design Cross sectional survey of 183 pediatrics and family medicine primary care providers in the Denver metro area. Results Response rate was 82% (n = 150). Most (59%) providers used a presumptive vaccine recommendation >75% of the time, and 76% reported continuing to offer the HPV vaccine even after parent refusal. However, less than two-thirds of providers “strongly” recommended the vaccine to 11–12 year olds (60% for females, 55% for males, p = 0.02). The HPV vaccine information sheet from the Centers from Disease Control and Prevention was the most frequently used communication tool during clinical visits (64% used at least 75% of the time) and directing parents to preferred websites was the most frequently used between-visit communication tool (21% used >50% of visits). Use of tools was not associated with any measure of HPV vaccine recommendation quality but was associated with longer HPV vaccine discussion times. Conclusions Providers use only limited types of adolescent HPV vaccine communication tools, and frequently do not use preferred vaccine communication strategies. Better engagement with existing HPV vaccine communication tools, and/or the creation of new tools may be needed to enhance providers’ ability to provide high quality HPV vaccine recommendations.
Q*cert: A Platform for Implementing and Verifying Query Compilers

We present Q*cert, a platform for the specification, verification, and implementation of query compilers written using the Coq proof assistant. The Q*cert platform is open source and includes some support for SQL and OQL, and for code generation to Spark and Cloudant. It internally relies on familiar database intermediate representations, notably the nested relational algebra and calculus and a novel extension of the nested relational algebra that eases the handling of environments. The platform also comes with simple but functional and extensible query optimizers. We demonstrate how the platform can be used to implement a compiler for a new input language or develop new optimizations that can be formally verified. We also demonstrate a web-based interface that allows the developer to explore various compilation and optimization strategies.
Dynamic Positioning of Ships Using Nonlinear Dynamic Surface Control

Abstract The paper addresses the general Dynamic Positioning problem for standalone and multiple coordinated ships using a refinement of the Dynamic Surface Control (DSC) methodology. DSC methods are "synthetic input techniques", similar to integrator backstepping. Backstepping methods suffer from "explosion of terms" problems when the model is differentiated. This problem is circumvented in DSC by the use of first-order filters. The DSC approach is modified to account for the particular form of the system dynamics and the modified approach is shown to guarantee boundedness of the tracking error semi-globally when the nonlinearities in the system are non-Lipschitz. Copyright © 2001 IFAC
Acute Hemodynamic Effects of Intra-aortic Balloon Counterpulsation Pumps in Advanced Heart Failure.

Abstract Background The utility of intra-aortic balloon counterpulsation pumps (IABPs) in low cardiac output states is unknown and no studies have explored the impact of IABP therapy on ventricular workload in patients with advanced heart failure (HF). For these reasons, we explored the acute hemodynamic effects of IABP therapy in patients with advanced HF. Methods We prospectively studied 10 consecutive patients with stage D HF referred for IABP placement before left ventricular assist device (LVAD) surgery and compared with 5 control patients with preserved left ventricular (LV) ejection fraction (EF) who did not receive IABP therapy. Hemodynamics were recorded using LV conductance and pulmonary artery catheters. Cardiac index (CI)-responder and CI-nonresponder status was assigned a priori as being “equal to or above” or below the median of the IABP effect on CI, respectively, within 24 hours after IABP activation. Results Compared with controls, patients with advanced HF had lower LVEF, lower LV end-systolic pressure, lower LV stroke work, and higher LV end-diastolic pressures and volumes before IABP activation. IABP activation reduced LV stroke work primarily by reducing end-systolic pressure. IABP therapy increased CI by a median of 20% as well as increased diastolic pressure time index and the myocardial oxygen supply:demand ratio. Compared with CI-nonresponders, CI-responders had higher systemic vascular resistance, lower right heart filling pressures, and a trend toward lower left heart filling pressures with improved indices of right heart function. Compared with CI-nonresponders, the diastolic pressure time index was increased among CI-responders. Conclusions IABP therapy may be effective at reducing LV stroke work, increasing CI, and favorably altering the myocardial oxygen supply:demand ratio in patients with advanced HF, especially among patients with low right heart filling pressures and high systemic vascular resistance.
3D structured illumination microscopy with unknown patterns and a statistical prior

We demonstrate resolution enhancement in 3D by structured illumination microscopy (SIM) with unknown illumination patterns. Our algorithmic self-calibration algorithm recovers both the image and the patterns, given a statistical prior.
Cation Exchange Induced Transformation of InP Magic-Sized Clusters

Magic-sized clusters (MSCs) can provide valuable insight into the atomically precise progression of semiconductor nanocrystal transformations. We report the conversion of an InP MSC to a Cd3P2 MSC through a cation exchange mechanism and attempt to shed light on the evolution of the physical and electronic structure of the clusters during the transformation. Utilizing a combination of spectroscopic (NMR/UV–vis) and structural characterization (ICP-OES/MS/PXRD/XPS/PDF) tools, we demonstrate retention of the original InP MSC crystal lattice as Z-type ligand exchange initially occurs. Further cation exchange induces lattice relaxation and a significant structural rearrangement. These observations contrast with reports of cation exchange in InP quantum dots, indicating unique reactivity of the InP MSC.
Multiple Sports Sponsorships: Is More Always Better? An Abstract

Brands which invest in sports sponsorships often sponsor a number of sports properties, many of which have fan bases with significant overlap. On the one hand, such investments in multiple properties may be done in hopes of achieving synergistic, positive effects for the brand. On the other hand, it could be argued that given high fan-base overlap, sponsorship investment in multiple sports properties is redundant and therefore an inefficient investment. A survey of 1,000 Americans focused on the effects of multiple sponsorships of a major US brand of antifreeze across three sports properties: NASCAR, NHRA, and the Professional Bull Riders (PBR) Tour. Awareness of one, two, or all three sponsorships was considered as a predictive variable with regard to outcomes of influence of the sponsorship toward brand preference and purchase intention. A MANOVA model revealed that sponsorship awareness had positive effects on purchase intention and that interactive effects were found in those cases an individual was aware of two sponsorships. Subsequent analysis was conducted to uncover how fan overlap across sports properties helps explain these synergistic effects.
LONG-TERM OUTCOMES AFTER INTERVENTION FOR PULMONARY ATRESIA WITH INTACT VENTRICULAR SEPTUM: A STUDY FROM THE PEDIATRIC CARDIAC CARE CONSORTIUM

Pulmonary atresia with intact ventricular septum (PA/IVS) can be treated by various operative and catheter-based interventional strategies. We aim to understand the long-term outcomes by each strategy. Cohort study from the Pediatric Cardiac Care Consortium (PCCC), a multi-institutional registry
Financial Performance Measurement, Worker Satisfaction, and the Influence of Zero-Sum Perceptions

Despite considerable research on how worker satisfaction affects the financial performance of firms, we know little about how firms’ measurement and reporting of financial performance affects the s...
The Many Roles of Control in a Stressor-Emotion Theory of Counterproductive Work Behavior

The Stressor-Emotion model of counterproductive work behavior (CWB) is based on prevalent approaches to emotions, the stress process in general and job stress in particular. The sense of control is key to the appraised coping capacity. A combination of perceived stressors and insufficient control is likely to trigger negative emotions, which in turn increase the likelihood the employee will engage in CWB, which we view as a special case of behavioral strain. We highlight the centrality of several conceptualizations of control in theories of general stress, work stress, and CWB. A critical concern is the paucity of empirical support for the interactive stressor-control effects posited by models at all three levels of stress theory.
The Kernel of an Idempotent Separating Congruence on a Regular Semigroup

Let S be a regular semigroup and E(S) its set of idempotents. Let θ be an idempotent separating congruence on S. Traditionally by the kernel ker θ of θ we understand the union of the idempotent θ-classes (see e.g. [4]). For an idempotent separating congruence θ the idempotent θ-classes are groups, namely the θ-classes containing idempotents. The kernel normal system of θ considered by Preston in [6] is the set of these idempotent θ-classes and contains more information than the above mentioned ker θ, which, after all, is just a subset of S. In the following we shall adopt still another approach to the concept of the kernel of an idempotent separating congruence on a regular semigroup. We shall give a survey of some of the results obtained in collaboration with K. S. S. Nambooripad.
Gastric volvulus: unraveling the diagnosis with MPRs

Gastric volvulus is a rare entity with a spectrum of acute and chronic clinical presentations. Body radiologists must be cognizant of the subtypes of gastric volvulus and identify potential complications. Mortality can be high if unrecognized from gastric necrosis, perforation, and sepsis. CT with multiplanar reformations is critical for complete evaluation beyond radiography and fluoroscopy. This article reviews clinical and imaging features of uncomplicated and complicated gastric volvulus, with the aim of guiding appropriate management.
Primary amides. A general nitrogen source for catalytic asymmetric aminohydroxylation of olefins.

N-Bromo,N-lithio salts of primary carboxamides have been shown to be efficient nitrogen sources for catalytic asymmetric aminohydroxylation of olefins, behaving much like the parent N-bromoacetamide in these reactions. α-Chloro-N-bromoacetamide is a particularly interesting nitrogen source, as it is functionalized for further reaction, including easy deprotection by treatment with thiourea.
Optimality Criteria of Economic Growth as Examples of Optimal Resource Allocation Over Time

This is my PhD dissertation defended in 1966 at the University of Minnesota and it was never published. It has been cited and used in other researchers work so I now make it available. The problem of optimal resource allocation over time is formulated as an optimal control problem. This is where the existence of optimal programs is investigated (and sufficient conditions are provided) for the first time in economics. When earlier authors spoke of existence, they spoke of convergence of the integral defining the optimality criterion. Optimal programs were characterized in terms of market equilibria at each point in time as well as imputed prices for stocks of capital.One of the propositions in the paper establishes the principle of centralization of planning and decentralization of implementation (this closely relates to polycenterism advocated by European socialist parties in the late 1950s. If one uses a measure space of traders instead of the basic time interval and assume pure exchange then the existence theorem of this paper can greatly simplify the proof of existence of equilibrium in a or a much more flexible model of exchange with continuum of traders.
A Physics-Informed Neural Network Framework for PDEs on 3D Surfaces: Time Independent Problems

Partial differential equations (PDEs) on surfaces are ubiquitous in all the nature science. Many traditional mathematical methods has been developed to solve surfaces PDEs. However, almost all of these methods have obvious drawbacks and complicate in general problems. As the fast growth of machine learning area, we show an algorithm by using the physics-informed neural networks (PINNs) to solve surface PDEs. To deal with the surfaces, our algorithm only need a set of points and their corresponding normal, while the traditional methods need a partition or a grid on the surface. This is a big advantage for real computation. A variety of numerical experiments have been shown to verify our algorithm.
What are the gender differences in risk and needs of males and females sentenced for white-collar crimes?

ABSTRACTReducing recidivism rates continues to be the focus of scholars and practitioners alike. While the risk-need-responsivity (RNR) principle model has guided correctional treatment services fo...
Role of Electronic Travel Aids: Field Applications of the Russell Pathsounder:

The Russell Pathsounder has been used successfully as a secondary travel aid to enable a partially sighted man to retain his job as a floor supervisor in a sheltered workshop, and to enable a neuro...
A REGION OF DROSOPHILA SLBP DISTINCT FROM THE HISTONE PRE-MRNA BINDING AND PROCESSING DOMAINS IS ESSENTIAL FOR DEPOSITION OF HISTONE MRNA IN THE OOCYTE

During Drosophila oogenesis, large amounts of histone mRNA and proteins are deposited in the developing oocyte. These are sufficient for the first 14 embryonic cell cycles and provide the developing embryo with sufficient histone proteins until the zygotic histone genes are activated. The maternally deposited histone mRNA is synthesized in stage 10b of oogenesis after completion of endoreduplication of the nurse cells. Histone mRNAs are the only cellular mRNAs that are not polyadenylated, ending instead in a conserved stemloop instead of a polyA tail. The Stem-loop binding protein (SLBP) binds the 3 prime end of histone mRNA and is essential for both the biosynthesis and translation of histone mRNA. We report that a 10 aa region in SLBP, which is not required for processing in vitro, is essential for transcription of histone mRNA in the stage 10b oocyte. In stage 10b the Histone Locus Bodies (HLBs) produce histone mRNAs in the absence of phosphorylation of Mxc, normally required for histone gene expression in S-phase cells. Mutants expressing this SLBP develop normally, produce small amounts of polyadenylated histone mRNA throughout development, but little histone mRNA in stage 10b resulting in death of the embryos in the first hr of development.
Anatomy and function of feeding

Abstract Like other mysticetes, bowhead whales are bulk filter feeders that use a keratinous oral filter of baleen to separate aggregated prey from seawater. Bowhead baleen plates and fringes are longer and finer than those of any other whale, creating low porosity, high surface area filtration with which to capture and retain very small copepods and other patchy zooplankton. The huge filter generates high drag, which is estimated to increase sixfold (with a 40% drop in swim speed) with open gape. Although filtering is energetically expensive, this strategy enables bowhead whales to subsist on less dense prey aggregations with shorter foraging bouts relative to right whales. Field observations, laboratory experiments, and morphological inference suggest that water flowing through the mouth involves both Bernoulli and Venturi effects to minimize bow waves and improve filtration, and that crossflow (tangential) filtration minimizes clogging while allowing prey to accumulate for easier swallowing.
The Effects of Regulation in the Presence of Multiple Unpriced Externalities: Evidence from the Transportation Sector

In transportation systems with unpriced congestion, allowing single-occupant low-emission vehicles in high occupancy vehicle (HOV) lanes to encourage their adoption exacerbates congestion costs for carpoolers. The resulting welfare effects of the policy are negative, with environmental benefits overwhelmingly dominated by the increased congestion costs. Exploiting the introduction of the Clean Air Vehicle Stickers policy in California with a regression discontinuity design, our results imply a best-case cost of $124 per ton of reductions in greenhouse gases, $606,000 dollars per ton of nitrogen oxides reduction, and $505,000 dollars per ton of hydrocarbon reduction, exceeding those of other options readily available to policymakers.
Capturing Collaboration with Interaction Dynamics Notation

Interaction Dynamics Notation (IDN), introduced by Sonalkar et al. in (Int J Des Creat Innov 1(2), 93–108, 2013), is a notation system for team collaboration. In the years since publication, it has garnered much interest and follow-up work. In this chapter, we consolidate much of the known work performed using IDN. We begin with an introduction to IDN, first abstractly through its description, origin, and symbol set, then concretely through short portions of team discussion. Then, we review research that references IDN, first detailing what is known about and through IDN, and second how IDN has been perceived and how it has inspired other work. We also report descriptive statistics of the symbols produced during collaboration, revealing patterns that help characterize the sequence of IDN symbols. Finally, we discuss two directions for future work.
Identification and quantification of distinct active sites in Hf-Beta zeolites for transfer hydrogenation catalysis

Abstract Despite the significant progress made in characterizing different framework heteroatom sites that exist in Lewis acidic zeolites with probe molecule adsorption and spectroscopy, methods to reliably quantify site counts remain indefinite and are primarily limited to Sn and Ti Lewis acid sites. Here, methods to quantify framework Lewis acidic Hf4+ sites in zeolite Beta (Hf-Beta) with two Lewis base titrants (pyridine, deuterated acetonitrile) were developed using infrared (IR) spectroscopy. Lewis acid site counts for Hf-Beta catalysts were validated by measuring integrated molar extinction coefficients (IMECs; e, cm μmol-1) on Sn-Beta zeolites using identical Lewis base titrants to benchmark site counts with established literature procedures to quantify Lewis acid sites in Beta zeolites from IR spectra. Highlighting the importance of benchmarking active site counts against well-established experimental protocols, IMECs of CD3CN bound to open (e(Sn; 2316 cm-1): 1.80 ± 0.25) and closed (e(Sn; 2308 cm-1): 3.76 ± 0.33) Sn sites were ∼1.8x larger than those previously reported while total Lewis acid site counts agreed with those measured by pyridine (e(Sn; 1451 cm-1): 1.58 ± 0.16) on six different Sn-Beta zeolites. IMECs measured for IR peaks reflecting pyridine bound to Lewis acidic Hf sites (e(Hf; 1448 cm-1): 1.54 ± 0.21) and CD3CN bound to open (e(Hf; 2313 cm-1): 2.40 ± 0.22) and closed (e(Hf; 2307 cm-1): 3.55 ± 0.41) Hf sites, gave similar counts for the total number of Lewis acidic sites across six Hf-Beta zeolites (Si/Hf = 100-413). Consistent with previous reports with Sn-Beta catalysts where open Sn sites are responsible for catalytic turnover, apparent first and zero-order MPVO rate constants (0.01-1 M cyclohexanone in 2-butanol; per total Hf, 373 K) correlated with the total number of open Hf sites, per total Hf, but not with the total number of closed Hf sites or total Lewis acid site counts. Measured initial MPVO rates (0.1 M cyclohexanone in 2-butanol, per open Hf, 373 K) were ∼25x higher on hydrophobic Hf-Beta-F than on hydrophilic Hf-Beta-OH zeolites. Overall, the apparent MPVO first-order rate constants (2-butanol solvent, per open Hf, 373 K) were ∼6x higher on Hf-Beta-F than on Hf-Beta-OH zeolites. The characterization methods reported here enable normalization of MPVO turnover rates on Sn- and Hf-Beta zeolites by their number of open sites. This enables performing quantitative rate comparisons across Lewis acid zeolites of varying active site identity, solvation, and pore topology used in liquid-phase catalysis.