cssi/SciSciGPT-SciSciNet huggingface dataset:
The Ideology of Addyi: Feminizing Medicine, or Medicalizing Femininity?

Sigmund Freud is famous for having asked, “What does a woman want?” In the context of therapeutic, interventional psychoanalysis, his unanswered question suggests another, even more unsettling one: “What should women want?” The so-called “female Viagra”, as flibanserin is so often called, is more polarizing than its manufacturer’s tagline, “the little pink pill,” suggests. While much attention has been paid to the advocacy surrounding Addyi, I wish to investigate how transformations of experimental techniques and diagnostic technologies have created this ideologically divisive medicalization of desire: that is, the material conditions for Addyi. Desire has been medicalized to accommodate historically contingent anxiety over female desire, and evolving diagnostic methods have attempted to reify desire into a medically treatable disorder; meanwhile, the trivialization of drugs like the Pill, Viagra, and Prozac has made Addyi viable, though still controversial.
A Performance Analysis of Line Differential Protection in Digitized Substations

In the circumstance of electronic transformers used in a digitized substation,line differential protection faces many new problems,mainly those about the data sharing for the protection units,the synchronization of data sampling between two line differential protection units in different substations,the mutual operation of protection units with other units in the process layer.A solution for clock signal synchronization based on the Ping-Pang principle is proposed with an analysis made of a solution for the performance and mutual operation based on the synchronous clock differential protection.
Disturbances of learning processes in the basal ganglia in the pathogenesis of Parkinson's disease: a novel theory.

AbstractA hypothesis is proposed that the cortico-basal ganglia-thalamocortical circuit is a neural optimal control system containing a model of the controlled object. To predict the behaviour of the object, the model uses the language of afferent signals that enter the system. Based on these ideas, it is suggested that the skeletomotor basal ganglia-thalamocortical circuit serves to model the motor behaviour of the body of an individual and its environment during motor planning and performance. Association basal ganglia-thalamocortical circuits are capable of modeling the behaviour, of abstract objects such as thoughts. Within the limits of the proposed theory, the dopaminergic system serves to distribute an error signal within the striatum. These error signals contain information about mismatch between model (predicted) afferent flow and real afferent flow coming from the controlled object. An error signal is necessary to tune the model on the object, and is delivered to a structure within the circuit t...
Inertial effects on thermal transport in superhydrophobic microchannels

Abstract This paper presents a numerical investigation on the effects of inertia for laminar fully developed flow in superhydrophobic microchannels where the surface structure consists of a square array of square pillars aligned with the flow direction. Infinite parallel plate channel flow is considered where the flow is assumed to be non-wetting and the meniscus is idealized as flat. A constant heat flux condition is imposed at the tops of the posts whereas the gas/liquid interface is assumed to be adiabatic. A wide range of Peclet numbers (1–10,000), relative channel spacing sizes (3 orders of magnitude), and solid fractions (0.02–0.9) are considered. The effect of these on friction factor-Reynolds number product, Nusselt number, hydrodynamic slip length and temperature jump length is explored. Frictional drag and convective heat transfer are reduced for all cases explored. These reductions are greater for small solid fractions, small relative channel sizes, and low Peclet numbers. Interestingly, over a wide range of explored parameters the results correspond well with the analytical diffusion dominated results present in the literature. It is only at the highest Peclet numbers and smallest relative channel sizes that the results deviate significantly from the diffusion dominated Stokes flow scenario. A mapping is presented that illustrates for which parameter ranges the influence of inertia and relative channel size become significant.
Phase II study of vindesine in patients with metastatic breast cancer

Twenty-six patients with far-advanced, refractory breast cancer were treated iv with vindesine (DVA) at a dose of 3 mg/m2/week. In 21 evaluable patients there were six partial remissions. Four patients who did not respond after at least four doses of intermittent DVA received continuous-infusion DVA at a dose of 1.5 mg/m2/day X 2 every other week; none responded. Five of the six responders had had disease progression on other vinca alkaloids. Leukopenia and neuromuscular toxicity were dose-limiting.
RubisCO selection using the vigorously aerobic and metabolically versatile bacterium Ralstonia eutropha.

UNLABELLED Recapturing atmospheric CO2 is key to reducing global warming and increasing biological carbon availability. Ralstonia eutropha is a biotechnologically useful aerobic bacterium that uses the Calvin-Benson-Bassham (CBB) cycle and the enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) for CO2 utilization, suggesting that it may be a useful host to bioselect RubisCO molecules with improved CO2 -capture capabilities. A host strain of R. eutropha was constructed for this purpose after deleting endogenous genes encoding two related RubisCOs. This strain could be complemented for CO2 -dependent growth by introducing native or heterologous RubisCO genes. Mutagenesis and suppressor selection identified amino acid substitutions in a hydrophobic region that specifically influences RubisCO's interaction with its substrates, particularly O2 , which competes with CO2 at the active site. Unlike most RubisCOs, the R. eutropha enzyme has evolved to retain optimal CO2 -fixation rates in a fast-growing host, despite the presence of high levels of competing O2 . Yet its structure-function properties resemble those of several commonly found RubisCOs, including the higher plant enzymes, allowing strategies to engineer analogous enzymes. Because R. eutropha can be cultured rapidly under harsh environmental conditions (e.g., with toxic industrial flue gas), in the presence of near saturation levels of oxygen, artificial selection and directed evolution studies in this organism could potentially impact efforts toward improving RubisCO-dependent biological CO2 utilization in aerobic environments. ENZYMES d-ribulose 1,5-bisphosphate carboxylase/oxygenase, EC 4.1.1.39; phosphoribulokinase, EC 2.7.1.19.
Synthesis of Self-Assembled Multifunctional Nanocomposite Catalysts with Highly Stabilized Reactivity and Magnetic Recyclability

In this paper, a multifunctional Fe3O4@SiO2@PEI-Au/Ag@PDA nanocomposite catalyst with highly stabilized reactivity and magnetic recyclability was synthesized by a self-assembled method. The magnetic Fe3O4 nanoparticles were coated with a thin layer of the SiO2 to obtain a negatively charged surface. Then positively charged poly(ethyleneimine) polymer (PEI) was self-assembled onto the Fe3O4@SiO2 by electrostatic interaction. Next, negatively charged glutathione capped gold nanoparticles (GSH-AuNPs) were electrostatically self-assembled onto the Fe3O4@SiO2@PEI. After that, silver was grown on the surface of the nanocomposite due to the reduction of the dopamine in the alkaline solution. An about 5 nm thick layer of polydopamine (PDA) was observed to form the Fe3O4@SiO2@PEI-Au/Ag@PDA nanocomposite. The Fe3O4@SiO2@PEI-Au/Ag@PDA nanocomposite was carefully characterized by the SEM, TEM, FT-IR, XRD and so on. The Fe3O4@SiO2@PEI-Au/Ag@PDA nanocomposite shows a high saturation magnetization (Ms) of 48.9 emu/g, which allows it to be attracted rapidly to a magnet. The Fe3O4@SiO2@PEI-Au/Ag@PDA nanocomposite was used to catalyze the reduction of p-nitrophenol (4-NP) to p-aminophenol (4-AP) as a model system. The reaction kinetic constant k was measured to be about 0.56 min−1 (R2 = 0.974). Furthermore, the as-prepared catalyst can be easily recovered and reused for 8 times, which didn’t show much decrease of the catalytic capability.
Tic Disorder and ADHD

The behavioral and neuropsychological characteristics of tic disorder, with or without attention-deficit hyperactivity disorder (ADHD), were examined in 78 children followed at Seoul National University College of Medicine, Korea.
Improving critical thinking via authenticity: the CASPiE research experience in a military academy chemistry course

Course-based undergraduate research experiences (CUREs) can introduce many students to authentic research activities in a cost-effective manner. Past studies have shown that students who participated in CUREs report greater interest in chemistry, better data collection and analysis skills, and enhanced scientific reasoning compared to traditional laboratory activities. Though self-reports are informative, performance measures are needed to evaluate CURE effectiveness objectively. The present study examines whether a CURE implementation at the United States Military Academy (by the Center for Authentic Science Practice in Education [CASPiE]) affects students' self-reported perceptions or critical thinking test scores. Students reported significant increases in their perceptions of learning through the laboratory, authentic scientific laboratory practices and interest in chemistry when compared to previous chemistry courses with traditional laboratory activities. Results also showed a significant increase in critical thinking scores, moderated by student perception of the authenticity of the laboratory activities.
Dynamic composition of protocol sub-systems for agile network services

The paper describes a management model where a service provider (SP) maintains multiple protocol modules to exercise the infrastructure resources (e.g., bandwidth, storage, servers) under various environment conditions. Each protocol depicts a distinctive work-flow among the networked entities (i.e., message exchanges and task coordination), incurring a certain amount of resource use. Different levels of performance optimality and fault resilience are thus achieved by various protocols in any given operating region of the network infrastructure and the environment. At run-time, the SP selects one of the protocol modules that meet the application's Quality of Service (QoS) specs against the prevailing operating conditions. A single shoe does not fit all sizes !! Our model allows a dynamic switching from one protocol module to another based on the changing environment conditions. A protocol configuration that is responsive to the dynamically changing conditions manifests as a highly agile and adaptive QoS offering. An enterprise service, for instance, may change its internal work-flow processes & procedures to quickly adapt to the changing business environment. The paper describes case studies of enterprise systems and content networks to exemplify the protocol switching as a foundation to build agile network services.
Understanding of the role of manganese in parkinsonism and Parkinson disease

Paracelsus is famous for saying “Poison is in everything, and no thing is without poison. The dosage makes it either a poison or a remedy.” The report in this issue of Neurology ® by Racette et al.1 titled “Dose-dependent progression of parkinsonism in manganese-exposed welders” provides evidence for a dose-response relationship between ongoing exposure to this neurotoxic heavy metal—which also plays an important role in the function of the antioxidant enzyme superoxide dismutase—and progression of parkinsonian symptoms.
High Resolution Single-Chip Radix II FFT Processor for High- Tech Application

Electrical motors are vital components of many industrial processes and their operation failure leads losing in production line. Motor functionality and its behavior should be monitored to avoid production failure catastrophe. Hence, a high‐tech DSP processor is a significant method for electrical harmonic analysis that can be realized as embedded sys‐ tems. This chapter introduces principal embedded design of novel high‐tech 1024‐point FFT processor architecture for high performance harmonic measurement techniques. In FFT processor algorithm pipelining and parallel implementation are incorporated in order to enhance the performance. The proposed FFT makes use of floating point to realize higher precision FFT. Since floating‐point architecture limits the maximum clock frequency and increases the power consumption, the chapter focuses on improving the speed, area, resolution and power consumption, as well as latency for the FFT. It illus‐ trates very large‐scale integration (VLSI) implementation of the floating‐point parallel pipelined (FPP) 1024‐point Radix II FFT processor with applying novel architecture that makes use of only single butterfly incorporation of intelligent controller. The functional‐ ity of the conventional Radix II FFT was verified as embedded in FPGA prototyping. For area and power consumption, the proposed Radix II FPP‐FFT was optimized in ASIC under Silterra 0.18 µm and Mimos 0.35 µm technology libraries.
Using Social Media as a Research Recruitment Tool: Ethical Issues and Recommendations.

The use of social media as a recruitment tool for research with humans is increasing, and likely to continue to grow. Despite this, to date there has been no specific regulatory guidance and there ...
Determination of morphological and linear udder traitsin Morkaraman, Tuj and Awassi sheep

In this study, it was aimed that determination of udder measurements of Morkaraman, Tuj and Awassi ewes and the correlation between the results. Udder depth and width of the Awassi was higher than other breeds and respectively 13.09±0.32 cm, 14.07±0.43 cm. In Morkaraman, teats length (2.65±0.06 cm) and diameter of the teats (1.83±0.06 cm) were higher from other breeds. The important statistical difference was found between breeds for udder depth (P<0.05), very important statistical difference was found between breeds for udder height and teats diameter (P<0.01). In this study, teats length and teats diameter were above the limits specified for machine milking for Morkaraman, Tuj and Awassi.
P015 Removal of selected non-specific reactivity in single antigen bead assays via FBS pre-treatment

Aim Non-specific reactivity is a known complication of single antigen bead (SAB), solid phase assays. Several approaches have been tried to reduce these reactions but are mostly related to Class I (eg: iBeads, acid treatment). No such treatments exist for Class II. Presently, the current lot of Class II SABs (LS2A01, Lot#: 011) has shown strong non-specific reactivity with some DRB1∗04 and DRB1∗16 bearing beads in patients who are otherwise non-sensitized; MFI values up to 4000. Previously, we reported that pre-treatment of patient serum with fetal bovine serum (FBS) effectively reduced non-specific binding to HLA Class I and Class II FlowPRA beads. In this study we sought to determine if FBS treatment would be effective in reducing/eliminating this non-specific class II reactivity. Methods Sera from 20 non-sensitized patients, each exhibiting the DR4/DR16 pattern, were pre-treated with FBS. Briefly, 5ul of FBS was added to 95ul of patient serum; incubated for 30 min at 37 °C; centrifuged and then used in the SAB assay. As controls, we treated sera from patients with well documented HLA antibody including DR4/DR16 (N = 10) and patients without HLA antibody (N = 10). Results Our results showed that in 100% (20/20) of the effected patients the DR4/DR16 reactivity was eliminated or significantly reduced. (Fig.). Importantly, patients with bona fide HLA antibody had no change in MFI values and additional reactivity was not observed in patients without HLA antibody following FBS treatment. Download : Download high-res image (339KB) Download : Download full-size image Conclusions In this study, we have demonstrated that the non-specific DR4/DR16 reactivity pattern was eliminated by pre-treatment with FBS. We speculate that this pattern is a result of reactivity against bovine peptides (possibly derived from culture media) present in the grove of the DR4/DR16 alleles. Pre-treating sera with FBS provides an exogenous source of soluble target proteins that interact with the antibodies thereby preventing their subsequent interaction with the beads.
Phylogenomics and species delimitation of a complex radiation of Neotropical suboscine birds (Pachyramphus).

Abstract Phylogeographic studies within the Neotropics continue to uncover hidden diversity, the extent of which remains poorly known. In birds, molecular studies are producing evidence that species-level diversity is substantially underestimated. Many avian taxa comprise large complexes of subspecies that often represent species-level taxa by various criteria. One such group of Neotropical suboscine birds, the becards (Pachyramphus), ranges from Argentina through northern Mexico. Their taxonomic limits have been complex and controversial as the genus has bounced around a number of suboscine families. Additionally, the phylogenetic relationships within Pachyramphus are unresolved due to insufficient sampling of taxa and populations across species’ ranges. We used target capture of ultraconserved elements for 62 individuals representing 42 taxa, and sequenced two mitochondrial genes and two nuclear introns covering 265 individuals of 51 taxa, including all recognized species, resulting in the most densely and completely sampled phylogenetic hypothesis for Pachyramphus to date. We delimited species using a traditional taxonomic approach and then tested them under a Bayesian multi-species coalescent framework. In doing so, we provide evidence for multiple young, previously undetected evolutionary lineages within Pachyramphus. Deep, well-supported branches and a high number of intraspecific lineages across the tree suggest that at least 50% of species diversity may be unrecognized.
Evaluation of interfractional variation of organs and displacement of catheters during high-dose-rate interstitial brachytherapy for gynecologic malignancies.

Abstract Purpose To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. Methods and Materials A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage. Single plan was generated from first-fraction CT fused with the MRI and used for all fractions of treatment. CT image was acquired before each treatment and registered to the first-fraction CT. Displacement of fiducials and catheters was calculated for each fraction and its effects on dosimetric parameters such as dose covering 90% for high-risk clinical target volume and intermediate-risk clinical target volume and dose to the 2 cm3 of the volume for bladder, rectum, sigmoid, and bowel were studied. Results Average movements of fiducials and catheters were 1.6 mm (range: 0.1–7.1 mm) and 1.7 mm (range: 0.1–4.5 mm), respectively. Overall, deviation of the delivered dose to the target in each fraction was insignificant for all patients (p-value: 0.66 for high-risk clinical target volume and 0.87 for intermediate-risk clinical target volume). The mean dose to organs at risk showed maximum difference up to 0.9, 2.7, 1.6, and 2.1 Gy for bladder, rectum, sigmoid, and bowel, respectively (p-value: 0.88, 0.34, 0.68, and 0.85 for bladder, rectum, sigmoid, and bowel, respectively). Conclusions The interfractional dosimetric variation for both target and organs at risk was within clinically acceptable limit throughout the entire course of interstitial HDR-Syed brachytherapy. Only 6% of cases performed replanning, which could be readily identified using CT imaging.
Determination of the structure of α-β interfaces in metastable β-Ti alloys

Abstract The crystallography and structure of the interfaces formed between refined hexagonal close packed (hcp) α precipitates and the body centered cubic (bcc) β matrix in a solution-treated and quenched metastable β titanium alloy, Ti-5Al-5Mo-5V-3Cr (wt%, Ti-5553), were investigated after heating to 600 °C and subsequently aging for 0 and 30 min, respectively. The two phases adopted the classical Burgers orientation, and the observed interfacial structures were analyzed using a topological model, i.e. they contained disconnections, as well as β crystal lattice dislocations acting as a lattice invariant deformation (LID). The structure of the α/β interface was observed along two mutually perpendicular directions, in high angle annular dark-field scanning transmission electron microscopy (HAADF-STEM). Viewed along the [ 0001 ] α : [ 110 ] β directions, an array of disconnections was observed to accommodate the misfit between the α and β crystals. While the spacing of these disconnections varied, the step height associated with them was always twice the { 112 } β interplanar spacing, and their Burgers vector b was [ − 0.019 0.019 0.034 ] β . When the interface was viewed along the [ 1 ¯ 1 ¯ 20 ] α : [ 1 ¯ 11 ] β direction, in the sample aged for 0 min at 600 °C the misfit between the two lattices along [ 0001 ] α : [ 110 ] β was so small that no misfit or lattice invariant dislocations were observed within the field of view, in contrast with the interface structure reported in other more conventional titanium alloys. After aging the sample for 30 min, however, the interfacial structure equilibrated, and crystal lattice dislocations were observed on the terrace planes, accommodating the LID, with b = 1 2 [ 1 ¯ 1 ¯ 1 ¯ ] β . Growth of the α precipitates is shown to occur principally by the emission of disconnections from the tip of the existing α precipitates into the β matrix, and its resulting conversion to α. These results, combined with analysis using the topological model, show that the nucleation and growth of the hcp α phase from the bcc β matrix in this alloy can be described in terms of the motion of disconnections, accompanied by the displacive diffusion necessary to accommodate the differences in composition between the α and β phases.
Should Student-Athletes be Paid?

The National Collegiate Athletic Association (NCAA) currently prohibits student-athletes from receiving compensation from many non-school-affiliated sources, including sports agents, advertising ag...
CHAPTER 11 – Propositional Calculus

Publisher Summary This chapter discusses propositional calculus. Although the special case of propositional variables really suffices for studying propositional formulas, it is useful in order to include later applications, to allow the more general case of an arbitrary language of atoms. With the use of the equal sign, all tautologies are equal to one another and likewise all unsatisfiable formulas are equal to one another. Equations, which are easily checked using truth tables, are the basis of the so-called Boolean algebra. In each row, the equations on the left and right can be obtained from one another by simply interchanging all occurrences. Any correct statement involving ⋀ ⋁ and 0, 1 can be translated into another correct statement in which 0 and 1 have been interchanged and ⋀ and ⋁ have been interchanged. Returning to the list of algebraic laws, it is noted that in particular the operations Λ and v are commutative and associative.
Critical Ethnography in the VMT Project

The approach of the VMT Project has usually been described as design-based research in the learning sciences. However, it can also be understood as ethnography, using a micro-ethnographic style of interaction analysis to study the construction of social order in the exotic culture of virtual math teams. This chapter reviews the history of critical ethnography (CE) to describe the orientation and concerns of a stream of social science theorizing that seems particularly relevant to the work of the VMT research team. CE adopted the ideas of critical social theory and philosophy from Kant to Habermas. It passed through two distinct generations of thought. After reviewing this history, the chapter focuses on three key phenomena that are characteristic of CE analysis: temporalizing, objectification and intersubjectivity. It then suggests that these phenomena are also significant within the VMT analysis (e.g., Chapter 6, Chapter 7, Chapter 8), where they receive detailed analysis of empirical data. The VMT Project can be seen as a productive extension of CE work in a contemporary social setting.
Leg Ulcers: Expanding the Differential

Cutaneous lower extremity ulcerations are major source of morbidity and mortality. It can be challenging to identify an underlying etiology. This review provides a systematic framework for generating a thoughtful differential diagnosis and workup approach. We also highlight recent discoveries in the pathophysiology and treatment approaches of leg ulceration. Venous leg ulceration is being treated with a number of promising new modalities including pentoxifylline, statin therapy, topical timolol, connexin-43 peptide antagonists, photodynamic therapy, and punch grafting. The role of vitamin K deficiency is gaining prominence with regard to calciphylaxis. Recognition of key risk factors and subtle physical exam findings can serve as clues to the underlying mechanism of cutaneous ulceration and direct a targeted workup for underlying systemic disease that may be ameliorated with appropriate therapy.
Novel ecological and climatic conditions drive rapid adaptation in invasive Florida Burmese pythons

Invasive species provide powerful in situ experimental systems for studying evolution in response to selective pressures in novel habitats. While research has shown that phenotypic evolution can occur rapidly in nature, few examples exist of genomewide adaptation on short "ecological" timescales. Burmese pythons (Python molurus bivittatus) have become a successful and impactful invasive species in Florida over the last 30 years despite major freeze events that caused high python mortality. We sampled Florida Burmese pythons before and after a major freeze event in 2010 and found evidence for directional selection in genomic regions enriched for genes associated with thermosensation, behaviour and physiology. Several of these genes are linked to regenerative organ growth, an adaptive response that modulates organ size and function with feeding and fasting in pythons. Independent histological and functional genomic data sets provide additional layers of support for a contemporary shift in invasive Burmese python physiology. In the Florida population, a shift towards maintaining an active digestive system may be driven by the fitness benefits of maintaining higher metabolic rates and body temperature during freeze events. Our results suggest that a synergistic interaction between ecological and climatic selection pressures has driven adaptation in Florida Burmese pythons, demonstrating the often-overlooked potential of rapid adaptation to influence the success of invasive species.
From the black church basement to the public pavement: Grassroots alliances, the sunday school, organized youth activism, and a public theology of education

AbstractThis article examines the efforts of Sunday school attendees to challenge racism in America during the 1930s, '40s, and '50s. Participants formed alliances with nonreligious Black activist movements such as the Southern Youth Negro Congress and the Youth Council of the National Association for the Advancement of Colored People to address issues that impacted African-American youth and adults as a result of racism and White supremacy while fighting for social, political, and economy equality and status as first-class citizens in America.
Abstract WP548: Incidence and Prevalence of Headache in Cranio-Cervical Artery Dissection Patients

Introduction: Spontaneous craniocervical artery dissection (CeAD) occurs commonly in healthy individuals without known risk factors for stroke, whereas traumatic CeAD varies widely from penetrating...
Usefulness of ICD electrograms analysis to distinguish endocardial vs epicardial ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy.

Introduction Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by an epicardial (EPI) to endocardial (ENDO) fibrofatty infiltration of the RV predisposing to both EPI and ENDO ventricular tachycardia (VT). The relative timing between the VT QRS onset on the far-field ventricular electrogram (VEGM) to the local activation time recorded at the RV apex on the near-field VEGM from stored implantable cardioverter-defibrillator (ICD) events of VT can be helpful to discriminate ENDO from EPI VT in ARVC. Methods and results We analyzed consecutive ARVC patients undergoing catheter ablation between 2006 and 2018. Only patients with retrievable ICD VEGMs of clinical VTs which could be matched with VTs induced at the time of ablation were included. A total of 26 VT events (16 ENDO, 10 EPI) from 19 ARVC patients were examined, yielding a mean far-field to near-field interval of 33 ± 15 ms for ENDO VTs and 52 ± 20 ms for EPI VTs (P = .020). At receiver-operating characteristic analysis, a far-field to a near-field interval of 60 ms or more ruled out ENDO VTs in 16 (100%) cases and identified EPI VTs with a positive predictive value (PPV) of 100% and a negative predictive value (NPV) of 73%. An interval of less than or equal to 30 ms ruled out EPI VTs in eight (80%) cases and diagnosed ENDO VTs with a PPV of 80% and an NPV of 50%. Conclusion Far-field to near-field ICD VEGM timing may be used to predict ENDO vs EPI VT in ARVC before ablation, indicating an ENDO origin if the timing is less than or equal to 30 ms and an EPI origin if greater than or equal to 60 ms.
Time and Cost Effective Fabrication of Stretchable Micro-Supercapacitor Patches Using a Vinyl Cutter

We use a desktop-size vinyl cutter as the fabrication platform for stretchable micro- supercapacitor patches with interdigital patterns. Compared with similar works, our method can greatly reduce the cost (by ~70%) and time (by ~70%) in fabrication process, because no photolithography -based procedures were required. Instead, electrode patterns, interconnects and patch outlines were defined by automated cutting blades at sufficient resolution (smallest feature ~100μm). This fabrication method is compatible with both spray- and electro-deposited active materials, and yields comparable capacitor performances to previously reported devices. Our stretchable micro-supercapacitor patches can sustain considerable mechanical deformation with no performance degradation, and be applied as convenient power-supply modules for temperature sensors and commercial LEDs.
Utilization of Imaging in the Management of Pediatric Dog Bites

Introduction: Dog bite injuries are common in children. There is no consensus on the management of these injuries. We hypothesize that imaging is over utilized in the initial workup of these patients. In an effort to reduce radiation exposure, we aim to determine which patient population and injury patterns would necessitate imaging studies for management. Methods: A retrospective IRB approved review was performed on all patients presenting with dog bites to our level I pediatric trauma center between 2013 and 2015. Data collected included: patient demographics, injuries and imaging studies …
ELLA SHOHAT, On the Arab-Jew, Palestine, and Other Displacements: Selected Writings (Pluto Press; 1 edition, 2017)

Author Biography: Jennifer Lynn Kelly is an Assistant Professor of Feminist Studies and Critical Race and Ethnic Studies at University of California, Santa Cruz. Her research broadly engages questions of settler colonialism, US empire, and the fraught politics of both tourism and solidarity. She is currently completing the manuscript for her first book, a multi-sited ethnographic study of solidarity tourism in Palestine.
Nuclear factor-kappa beta signaling is required for transforming growth factor Beta-2 induced ocular hypertension

A major risk for the development of primary open-angle glaucoma (POAG) is elevated intraocular pressure (IOP). Elevated IOP is caused by increased outflow resistance due in part to excessive extracellular matrix (ECM) deposition in the trabecular meshwork (TM). The role of transforming growth factor beta 2 (TGFβ2) in inducing ECM production is well understood. Recent studies suggest that toll-like receptor 4 (TLR4) plays an important role in fibrogenesis. We have previously described a crosstalk between TGFβ2 and TLR4 in the development of ocular hypertension and glaucomatous TM damage. Nuclear factor-kappa beta (NF-κB) is critical for TLR4 signaling. To determine the transactivation of NF-κB, TM cells were stimulated with cellular fibronectin containing the EDA isoform (cFN-EDA), TGFβ2, or lipopolysaccharide (LPS) in combination with a selective TLR4 inhibitor. cFN-EDA, TGFβ2, and LPS all induced transactivation of NF-κB and inhibition of TLR4 blocked the effect of each treatment paradigm. To evaluate the role of NF-κB in IOP regulation, we utilized our inducible mouse model of ocular hypertension by injection of Ad5.TGFβ2 in mice harboring a mutation in NF-κB and wild-type controls. IOP was measured over time and eyes accessed by immunohistochemistry for the ECM protein FN and the specific FN-EDA isoform. Ad5.TGFβ2 induced ocular hypertension and expression of FN and FN-EDA in wild-type mice, but mutation in NF-κB blocked the effect. These data suggest that NF-κB is necessary for TGFβ2-induced ECM production and ocular hypertension and the transactivation of NF-κB is dependent on both TGFβ2 and TLR4.
Energy Literacy: The Energy Balance for Business Decisions

Everyday business decisions have an impact on energy. Although many consider energy to be an engineering discipline, the management of it is actually an organizational problem. Behind every electric bill is a piece of equipment that consumed it, a person operating the equipment, a team managing the person, and so on until we reach corporate policies and strategies. This chapter uses energy equations to explore which variables are determined by technical achievements and which are governed by human behavior. This will demonstrate the relationships between business decisions and energy outcomes. Energy strategists need to be aware of these linkages and can use this chapter to diagnose which decisions in one’s organization may have an underappreciated impact on energy.
Aerosol deposition in 3D models of the upper airways and trachea of rhesus macaques

Little is known about aerosol deposition in macaques, variability in deposition between animals, or how deposition in macaques and humans compare. This is despite the use of macaques in assessments...
Refusal to Bear Weight in a 3-year-old Girl with Autism Spectrum Disorder

1. Allison E. Williams, MD*,† 2. Maanasi Mistry, MD*,† 3. Maria Widmann, MD*,† 1. *UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA; and 2. †University of Pittsburgh, Pittsburgh, PA 1. Address correspondence to Allison E. Williams, MD, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA 15224. E-mail: williamsae2{at}upmc.edu A 3-year-old girl with autism spectrum disorder presents with bilateral knee swelling, lower extremity pain, and refusal to bear weight. Six weeks ago, she developed right ankle pain and limping, without swelling, erythema, or trauma to the joint. Over the next month, she developed bilateral knee pain and swelling, and refusal to bear weight. She has no joint swelling or abnormalities of the upper extremities. Review of systems is positive for intermittent lower extremity joint swelling, and erythematous papular rash of the lower extremities starting 2 days before presentation. There have been no recent fever, weight loss, viral symptoms, or dietary changes. She is otherwise healthy and fully vaccinated. Her family history is negative for hematologic and rheumatologic disorders. On examination, she is nonverbal and upset by interaction with health-care providers. Her vital signs are normal. She is the first percentile for weight and the 15th percentile for height. She has a normal head, ears, eyes, nose, and throat examination, with no gingival changes or bleeding. Her cardiac and pulmonary examinations have no significant abnormal findings. She has bilateral knee swelling with limited passive range of motion. She will not participate in the examination to evaluate active range of motion. There is no erythema, warmth, or effusion of either knee. She appears to have tenderness to palpation of her bilateral distal femur and proximal tibia. Her upper extremity joints and bilateral hips and ankles have full passive range of motion, 5/5 strength, and are otherwise unremarkable without tenderness. She has a diffuse, erythematous, nonblanching, papular, and pinpoint rash of the bilateral lower extremities. She refuses to bear weight. Her …
HPLC Comparison of Tear Film Protein Pattern in Normal and Infectious Bovine Keratoconjunctivitis Affected Cattle

Purpose: This project was undertaken to establish the tear protein pattern in normal cattle and changes in the pattern at different stages of IBK, and disease of great economic importance. Methods: Non-stimulated tears were atraumatically collected with a 50μ1 capillary tube. The study included normal and infected animals in three stages of naturally occurring IBK. Analysis was performed with a TSK 3000 SWXL size exclusion HPLC column at a flow rate of 0.3ml/min with 0.5M NaCl, 0.1M NaH3PO4, pH 5. Quantitation was completed with computerized integration of peaks. Results: In all animals 7 major peaks were found at retention times of 17, 19, 21, 27, 29, 33, and 39 minutes. During the active course of the disease, peaks 1, 2, 3, 5, 6, and 7 showed various changes. Separation for different bacterial culture result within the group had statistically significant differences. Conclusions: The tear protein pattern in IBK affected cattle versus normal shows distinct changes. In addition to the stage of the disease changes are markedly influenced by the type of recovered organism. The first three peaks that changed in size during the course of the disease are likely to contain immunoglobulins.
Sport Specialization in Middle- and High-School Long-Distance Runners.

CONTEXT Previous reports suggest high-specialized adolescent athletes may be at a higher risk of injury, worse sleep quality, and lower sport enjoyment than low-specialized athletes. Currently, sport specialization literature is primarily composed of adolescent athletes from a variety of sports. However, it is unknown if the findings on sport specialization from predominantly non-running athletes are generalizable to adolescent long-distance runners. OBJECTIVE Compare injury history, running volume, quality of life, sleep habits, and running enjoyment among male and female middle- and high-school long-distance runners from different sport specialization levels. DESIGN Cross-sectional. SETTING Online survey. PARTICIPANTS A total of 102 male (age=15.8±0.9 years) and 157 female (age=15.6±1.4 years) uninjured middle- and high-school athletes who participated in long-distance running activities (completion rate=50.7%). MAIN OUTCOME MEASURE(S) Participants were stratified by sex and sport specialization level (low, moderate, high). Group differences in self-reported running-related injuries, EQ-5D-Y quality of life, Pittsburgh Sleep Quality Index sleep quality, sleep duration, running habits, and running enjoyment were assessed. RESULTS High-specialized male and female middle- and high-school long-distance runners reported competing more months per year (p<0.001), higher weekly run distance (p<0.001), more runs per week (p<0.001), higher average distance per run (p<0.001), and higher running enjoyment (p<0.001) than low-specialized runners. Males reported higher average weekly run distance (p=0.01), higher average distance per run (p=0.01), and better sleep quality (p=0.01) than females. No differences among sport specialization were found for running-related injuries (p=0.25), quality of life (p=0.07), sleep quality (p=0.19), or sleep duration (p=0.11) among male or female middle- and high-school runners. CONCLUSIONS High-specialized male and female middle- and high-school long-distance runners reported higher running volumes and running enjoyment than low-specialized runners. However, high-specialized runners did not report a greater number of running-related injuries, lower quality of life, or lower sleep quality or duration as expected.
Psychology Research Methods: Connecting Research to Students' Lives

Comprehensive, engaging, and punctuated with humor, this undergraduate textbook provides an interesting introduction to research methodology. Psychology Research Methods allows students to become familiar with the material through examples of research relevant to their lives. The textbook covers every major research approach in psychology. Students will learn how to evaluate and conduct the different varieties of descriptive research and experimental research. They will learn all steps of the research process from developing a research idea to writing about and presenting what they did. Each chapter contains suggestions for journal article readings and activities relevant to the topics covered. The textbook also includes a chapter on how to conduct research online and an appendix with an annotated manuscript keyed to the current edition of the American Psychological Association Publication Manual.
Machine learning moment closure models for the radiative transfer equation III: enforcing hyperbolicity and physical characteristic speeds.

This is the third paper in a series in which we develop machine learning (ML) moment closure models for the radiative transfer equation (RTE). In our previous work \cite{huang2021gradient}, we proposed an approach to learn the gradient of the unclosed high order moment, which performs much better than learning the moment itself and the conventional $P_N$ closure. However, while the ML moment closure has better accuracy, it is not able to guarantee hyperbolicity and has issues with long time stability. In our second paper \cite{huang2021hyperbolic}, we identified a symmetrizer which leads to conditions that enforce that the gradient based ML closure is symmetrizable hyperbolic and stable over long time. The limitation of this approach is that in practice the highest moment can only be related to four, or fewer, lower moments. In this paper, we propose a new method to enforce the hyperbolicity of the ML closure model. Motivated by the observation that the coefficient matrix of the closure system is a lower Hessenberg matrix, we relate its eigenvalues to the roots of an associated polynomial. We design two new neural network architectures based on this relation. The ML closure model resulting from the first neural network is weakly hyperbolic and guarantees the physical characteristic speeds, i.e., the eigenvalues are bounded by the speed of light. The second model is strictly hyperbolic and does not guarantee the boundedness of the eigenvalues. Several benchmark tests including the Gaussian source problem and the two-material problem show the good accuracy, stability and generalizability of our hyperbolic ML closure model.
Redivorce Following Remarriage: A Re-Evaluation.

This paper examines the use of the often quoted remarriage studies done in the 50s by Monahan. It was found that extreme caution should be used in presentations where the redivorce rate is discussed. The current statistics certainly do not paint the bleak picture presented by Monahan. Surprisingly, when 28 current family texts were sampled for their treatment of remarriage, it was found that most do not even address the topic, and of those who do, most present the older and misleading Monahan data. It is suggested in the paper that researchers, educators, and counselors need an accurate view of the risk of remarriage following divorce, since most of those who divorce do remarry. Also, the suggestion was made that the traditional family form may not be in as much of a decline as some report. Most people stay married; of those who divorce, most (68%) have either one child or none, and most remarry.
Belief, Truth, and Positive Organizational Deviance

Black Greek-Letter Organizations (BGLOs) are unique institutions. Though few in number, they claim some of this country’s most renowned African American leaders – e.g., Charles Hamilton Houston (architect of the NAACP Legal Defense Fund’s Brown v. Board strategy), Rosa Parks (mother of the Civil Rights Movement), Earl B. Dickerson (civil rights lawyer and first black University of Chicago Law School graduate), Sadie Alexander (first African American woman to earn a PhD, and first to earn a JD from the University of Pennsylvania), and William Hastie (first African American federal judge). Uniquely, BGLOs’ members tend to remain deeply committed to their organizations over a life-course. Even more, BGLOs tend to initiate large numbers of members into highly functioning alumni chapters. One thing that is most striking about BGLOs, however, is a particularly violent brand of hazing employed to initiate their new members. While there have been reforms within BGLOs to curtail hazing injuries, deaths, and legal wrangling (both civil and criminal), violent hazing within them persists. A host of reasons may explain why law fails to constrain legally consequential behavior within organizations like BGLOs. This article seeks to empirically ascertain (1) what beliefs may undergird BGLO hazing and (2) the extent to which beliefs about the utility of hazing as a means to actualize the essential ingredients of BGLO existence (i.e., commitment to the organization, its ideals, and members) are well-founded. We close by reconciling the tension between these findings and how law attempts to constrain behavior.
Efficient Auction Mechanisms with Interdependent Valuations and Multidimensional Signals

We develop an auction model for the case of interdependent values and multidimensional signals in which agents' information is not independent. We show that a modification of the Vickrey auction which includes payments to the bidders will result in an efficient outcome under very good general conditions. Further, we provide a definition of informational size such that the necessary payments to bidders will be arbitrarily small if agents are sufficiently informationally small.
The Holiness of Yiddish: Who Says Yiddish Is Holy and Why?.

The pace of sanctifying profane vernaculars is speeding up and the process is spreading outside of its European primary base. The sanctification of Yiddish as revealed in writing about the language suggests a number of distinctions within sanctity as well as crucial associations with special individuals, literary works, kinship relationships and heightened suffering which are tied to ascriptions of sanctity, by secular as well as religious spokespersons. However, two profiles emerge,which differ in details which are highly revealing of the bases upon which Jewish secularists and religionists ascribe sanctity.