cssi/SciSciGPT-SciSciNet huggingface dataset:
Correcting for discretionary treatment crossover in an analysis of survival in the Breast International Group BIG 1-98 trial by using the inverse probability of censoring weighted method.

likely occurred in some individuals. The mean scores probably obscured some women with substantial symptoms or impairments and others who adapted or even experienced improved quality of life. Similarly, low mean scores for symptoms might be interpreted as indicating that all women had mild symptoms, whereas clinical experience reminds us that some women are extremely bothered by their symptoms. The proportions of women at various time points with substantially impaired quality of life and severe symptoms would also be worth knowing, especially when counseling women considering adjuvant therapy. More than half the women in these studies 2,3 were prescribed adjuvant tamoxifen, typically continued for 5 years. For some women, the adverse effects of long-term tamoxifen may be more troublesome than the short-term adverse effects of chemotherapy. For example, studies of preferences have shown that compared with women treated with adjuvant chemotherapy, women treated with adjuvant endocrine therapy judged greater survival benefits necessary to make their treatment worthwhile. 7-9 Endocrine therapy is an important potential cause of symptoms persisting 12 and 24 months after primary treatment. Before relating these results back to the clinic, we must remember that the women in these studies 2,3 were participants in randomized clinical trials; they may not be representative of the broader population of patients with cancer, which includes those with comorbidities who are at risk of poorer quality of life. 10-12 Overall, the message from the studies reported by Ganz et al 2,3 is that recovery takes time. Women of all ages with early breast cancer are at risk for a number of persisting problems, independent of their menstrual status and receipt and duration of chemotherapy. The mechanisms causing these symptoms and their persistence warrant additional study. Learning how to identify individuals at greatest risk of severe or persistent symptoms and impaired quality of life will help us devise and target interventions to prevent and manage these problems. In the meantime, these studies will help us warn and prepare women about the likelihood, severity, and duration of lingering problems after adjuvant systemic therapy.
Self-reported multicultural supervision competence of White predoctoral intern supervisors.

This study assessed the self-reported supervision practices, experiences, and multicultural competence of White intern supervisors (n 211). White training directors and staff psychologists who were currently supervising predoctoral interns completed a 2-page survey regarding their multicultural supervision. Female supervisors reported higher multicultural supervision competence and spent more time processing cultural differences with their supervisees than male supervisors. Training directors also reported higher multicultural supervision competence than staff psychologists. Further, the number of interns supervised currently and over a career significantly predicted multicultural supervision competence. Recommendations for White intern supervisors include ongoing participation in education and professional practice experiences to improve multicultural supervision competence.
One canonical form for higher-index linear time-varying singular systems

One form of the singular systemAx′+Bx=f is considered. The analytic solution, perturbation, and numerical solution of this form are examined. A class of systems which may be transformed into this form without altering these properties is characterized.
The effects of stimulus familiarization on patterns of visual selection

Patterns of visual selection were recorded as Ss viewed pairs of stimulus drawings in which the two members were either both incongruous or both banal. Prior to presenting the paired stimuli, S was preexposed to either one member of the stimulus pair or to the incongruous or banal counterpart of one member of the stimulus pair. The results indicate that: (1) preexposure to a stimulus reduced its potential to elicit looking responses, and the magnitude of that reduction was greater for incongruous stimuli than for banal stimuli; (2) preexposure to an incongruous stimulus affected the potential of its banal counterpart to elicit looking responses, but preexposure to a banal stimulus did not affect the potential of its incongruous counterpart to elicit similar responses; and (3) the reduced potential of the preexposed member of a stimulus pair to elicit looking responses waned after 10 sec. These results were discussed in light of an “information-conflict resolution” model of visual selection.
Using a Concept-Grounded, Curriculum-Based Measure in Mathematics to Predict Statewide Test Scores for Middle School Students with LD

From a larger sample of field-tested mathematics production response items, 11 were selected that individually (a) differentiated between high and low achievers on a general math achievement test, (b) measured a mathematical concept rather than a procedure, and (c) were conducive to the creation of alternate forms of the items. This math concept curriculum-based measure (CBM) was administered to 171 students in eighth grade. Scores were correlated with scores from a computer adaptive test (CAT) designed in conjunction with the state to approximate the official statewide mathematics achievement test. Correlations for general education students (r = .80; n = 90) and students with learning disabilities (r = .61; n = 81) were high. Regression analysis showed that relatively few of the 11 items were needed to predict CAT scores. Implications for students with learning disabilities, who traditionally receive little instruction in conceptual understanding, are discussed.
Calculation of average molecular properties during nonlinear, living copolymerization

Abstract : Describing network formation during chainwise polymerization is more complex than for stepwise (condensation) systems. The kinetics of chain growth must be combined with probability laws for random linking between chains. This approach is used to derive molecular weight averages, gel point and sol fraction during living, anionic copolymerization of vinyl with divinyl monomers. Comparison of predicted molecular weight and gel point to experimental values from Worsfold (1970), Lutz, Beinert and Rempp (1982) and others indicate that a significant amount of intramolecular linking or cyclization occurs in this system. Keywords: Anionic polymerization, Crosslinking, Network properties, Nonlinear living copolymerization, Molecular structure, Numerical methods.
Making a case for HCI: comparing materials for case-based teaching

This paper investigates case-based methods for bridging the conflicting goals of providing both topic coverage and practical experience in teaching human-computer interaction (HCI). We evaluate benefits and limitations of five types of case materials - contemporary articles, professionally prepared cases, familiar interfaces, ongoing development projects, and incomplete information (jigsaw) - to probe how they should be structured and approached by an HCI instructor. Through an experience that assessed case-based activities in an undergraduate HCI course, we determined tradeoffs relating to student participation, preparation characteristics, and short- and long-term learning outcomes. Based on our results, we can make several conclusions that should influence selection and development of materials for case-based pedagogy, and we illustrate the need for structured case creation processes that can be performed conjointly with system development efforts.
Nucleases and helicases take center stage in homologous recombination

Homologous recombination (HR)-mediated DNA double-strand break repair maintains genome integrity. Although long-studied, an understanding of two essential steps in this process – the resection of DNA ends to produce recombinogenic 3′ single-stranded DNA tails and the resolution of recombination intermediates – has remained elusive. Recent findings show an unexpected role for the Sgs1 (BLM) helicase and Dna2 nuclease in end resection, and provide mechanistic insight into the initiation of 5′–3′ resection as well as its regulation by the cell cycle and the DNA damage response. Moreover, the identification of a novel Holliday junction resolvase, Yen1 (GEN1), and several helicases that dismantle strand invasion intermediates has increased the repertoire of nucleases and helicases capable of resolving recombination intermediates.
Mary Lynette Larsgaard: Mapping a Life Journey

Not many people know before they are twenty that they want to be a map librarian. Mary Lynette Larsgaard did. Few professionals have so dedicated their entire careers to maps and global imagery to ...
Shot-profile Migration of Multiple Reflections

A shot-profile migration algorithm is modified to image multiple reflections at their correct location in the subsurface. This method replaces the impulsive source with an areal source made of recorded primaries and multiples. In addition, the extrapolated wavefield at the receivers consists of recorded multiples only which have been previously separated from the primaries. Migration results with 2-D synthetic and field data prove that the migration of multiples can bring valuable structural information of the earth with or without separation.
Room-temperature superfluidity in graphene bilayers

Because graphene is an atomically two-dimensional gapless semiconductor with nearly identical conduction and valence bands, graphene-based bilayers are attractive candidates for high-temperature electron-hole pair condensation. We present estimates which suggest that the Kosterlitz-Thouless temperatures of these two-dimensional counterflow superfluids can approach room temperature.
Robert Jenson's Systematic Theology : a review essay

The essay explores the inner logic that connects Jenson's view of the work of Christ, the person of Christ, and the doctrine of God. More specifically, it examines his understanding of the cross, the incarnation, and the trinity. Despite clear intentions to the contrary, Jenson lands outside the bounds of established ecumenical consensus. His view of the cross tends toward Socinus, of the incarnation toward Arius, and of the trinity toward Hegel in ways that seem subordinationist and tritheistic. One possible reason for this outcome is a rationalistic mindset that displays a low tolerance for paradox in dogmatic theology.
Effects of plant species diversity, atmospheric [CO2], and N addition on gross rates of inorganic N release from soil organic matter

A significant challenge in predicting terrestrial ecosystem response to global changes comes from the relatively poor understanding of the processes that control pools and fluxes of plant nutrients in soil. In addition, individual global changes are often studied in isolation, despite the potential for interactive effects among them on ecosystem processes. We studied the response of gross N mineralization and microbial respiration after 6 years of application of three global change factors in a grassland field experiment in central Minnesota (the BioCON experiment). BioCON is a factorial manipulation of plant species diversity (1, 4, 9 and 16 prairie species), atmospheric [CO2] (ambient and elevated: 560lmolmol � 1 ), and N inputs (ambient and ambient 14gNm � 2 yr � 1 ). We hypothesized that gross N mineralization would increase with increasing levels of all factors because of stimulated plant productivity and thus greater organic inputs to soils. However, we also hypothesized that N addition would enhance, while elevated [CO2] and greater diversity would temper, gross N mineralization responses because of increased and reduced plant tissue N concentrations, respectively. In partial support of our hypothesis, gross N mineralization increased with greater diversity and N addition, but not with elevated [CO2]. The ratio of gross N mineralization to microbial respiration (i.e. the ‘yield’ of inorganic N mineralized per unit C respired) declined with greater diversity and [CO2] suggesting increasing limitation of microbial processes by N relative to C in these treatments. Based on these results, we conclude that the plant supply of organic matter primarily controls gross N mineralization and microbial respiration, but that the concentration of N in organic matter input secondarily influences these processes. Thus, in systems where N limits plant productivity these global change factors could cause different long-term ecosystem trajectories because of divergent effects on soil N and C cycling.
THE RELATIONSHIP BETWEEN CHILDHOOD MALTREATMENT AND ADOLESCENT INVOLVEMENT IN DELINQUENCY

Recent research suggests a link between childhood maltreatment and later involvement in delinquency. This study examines this issue using official and self-report data from the Rochester Youth Development Study. The analysis addresses three central issues: the magnitude of the relationship between early child maltreatment and later delinquency, official and self-reported; the possibility of spuriousness in this relationship; and the impact of more extensive measurement of maltreatment on later delinquency. A significant relationship between child maltreatment and self-reported and official delinquency is found and this relationship, especially for more serious forms of delinquency, remains when controlling for other factors. The results also suggest that more extensive maltreatment is related to higher rates of delinquency. Implications and suggestions for further research are discussed.
Pulmonary versus systemic hemodynamics in determining exercise capacity of patients with chronic left ventricular failure.

Right, but not left ventricular ejection fraction correlates with exercise capacity in patients with left ventricular failure, suggesting an important role of the pulmonary circulation. Hemodynamics were measured at rest and during bicycle exercise to symptomatic maximum in 41 patients with chronic left ventricular failure. Maximal oxygen consumption averaged only 12.8 ± 5.2 ml/min/kg. Pulmonary wedge pressure rose from 21.9 ± 8.2 to 35.9 ± 9.3 mm Hg during exercise, while pulmonary arterial mean pressure rose from 31.8 ± 10.9 to 50.4 ± 12.9 mm Hg (both p < 0.0001). Resting cardiac index and resting systemic arterial mean pressure did not correlate with maximal oxygen consumption (r = 0.23 and 0.20, respectively), which, however, did correlate with pulmonary wedge pressure (r = −0.54, p < 0.001). Maximal oxygen consumption did not correlate with resting systemic vascular resistance (r = −0.20) or resting pulmonary vascular resistance (r = −0.26). During exercise, total pulmonary resistance remained unchanged at 6.5 ± 3.8 U while systemic vascular resistance fell significantly. The relation between total pulmonary resistance and exericise capacity and the failure of total pulmonary resistance to fall during exercise suggest that afterload on the right ventricle may be an important determinant of exercise capacity in patients with chronic left ventricular failure.
Weakly canonical transformations and the path integral quantization

Abstract It is observed that for dynamical systems with constraints, the group of invariance transformations for the path integral transition amplitude is larger than the group of canonical transformations. This larger group of transformations is then employed to show that the condition {χa, χb} = 0 imposed on the gauge fixing terms for quantization is not necessary at all for a large class of dynamical systems, among which of particular interest is QCD.
A tight lower bound for optimal bin packing

In this paper, we present an O(n log n) algorithm to compute a tight lower bound for the one-dimensional bin packing problem. We have simulated the algorithm on randomly generated bin packing problems with item sizes drawn uniformly from (a, b), where 0 = = B, the error is less than 0.003%.
Open and laparoscopic surgical techniques for obtaining enteral access

Delivery of adequate parenteral nutrition requires secure and reliable access to the gastrointestinal tract. In most circumstances, the percutaneous endoscopic gastrostomy (PEG) tube offers reliable access with low morbidity. There are situations, however, in which PEG is not advisable or possible, and an alternate means of obtaining gastrointestinal access is necessary; these include patients who do not tolerate direct intragastric feeds, those with some types of aerodigestive cancers, and clinical scenarios in which the stomach may later be used for an operative conduit. Open and laparoscopic gastrostomy and jejunostomy tubes are alternatives to PEG. Each technique has its own advantages and disadvantages. An individualized approach to enteral access usually works best.
Improved limited discrepancy search

We present an improvement to Harvey and Ginsberg's limited discrepancy search algorithm, which eliminates much of the redundancy in the original, by generating each path from the root to the maximum search depth only once. For a complete binary tree of depth d, this reduces the asymptotic complexity from O(d+2/2 2d) to O(2d). The savings is much less in a partial tree search, or in a heavily pruned tree. The overhead of the improved algorithm on a complete b-ary tree is only a factor of b/(b - 1) compared to depth-first search. While this constant factor is greater on a heavily pruned tree, this improvement makes limited discrepancy search a viable alternative to depth-first search, whenever the entire tree may not be searched. Finally, we present both positive and negative empirical results on the utility oflimited discrepancy search, for the problem of number partitioning.
Delayed histopathological neuronal damage in the substantia nigra compacta (nucleus A9) after transient forebrain ischaemia.

Neurones in the rat substantia nigra compacta (SNC) are initially resistant to transient forebrain ischaemia in contrast to vulnerable neurones in the striatum that die within 24 h. Animals were exposed to 20 min of four vessel occlusion and killed 1 and 3 weeks after reperfusion. All ischaemic animals had striatal neurone loss. Analysis of the number of tyrosine hydroxylase immunoreactive neurones (THir) in the SNC was comparable between controls and ischaemic animals killed 1 week after reperfusion. However, there was a significant reduction in THir neurone number (24%), SNC volume (17%), and THir dendritic arborization in the substantia nigra reticulata (SNR) that occurred 3 weeks after reperfusion, despite the persistence of THir axons in the striatum. Detailed morphological analysis of areas distant from the initial ischaemic injury suggest delayed degeneration may play an important role in the brain's response to ischaemia, and may provide insights for clinical stroke treatment and management.
Block copolymer electrolytes for rechargeable lithium batteries

Ion-conducting block copolymers (BCPs) have attracted significant interest as conducting materials in solid-state lithium batteries. BCP self-assembly offers promise for designing ordered materials with nanoscale domains. Such nanostructures provide a facile method for introducing sufficient mechanical stability into polymer electrolyte membranes, while maintaining the ionic conductivity at levels similar to corresponding solvent-free homopolymer electrolytes. This ability to simultaneously control conductivity and mechanical integrity provides opportunities for the fabrication of sturdy, yet easily processable, solid-state lithium batteries. In this review, we first introduce several fundamental studies of ion conduction in homopolymers for the understanding of ion transport in the conducting domain of BCP systems. Then, we summarize recent experimental studies of BCP electrolytes with respect to the effects of salt-doping and morphology on ionic conductivity. Finally, we present some remaining challenges for BCP electrolytes and highlight several important areas for future research. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2014, 52, 1–16
Using satellite remote sensing analysis to evaluate a socio-economic and ecological model of deforestation in Rondônia, Brazil

The effectiveness of an integrated socio-economic and ecological simulation model for estimating patterns and rates of deforestation in Rondonia, Brazil is evaluated using Landsat data and landscape pattern metrics. The Percent Cleared, Contagion, and Fractal Dimension of image classifications are compared to those determined from model outputs. Results indicate that rates and spatial patterns of deforestation are similar between model outputs and Landsat image analysis. Differences in clearing patterns between the model and Landsat data are due in part to topography, localized farming obstacles and the patchiness of clearings. The effects of varying spatial resolution on the metrics is also examined.
Relaxation in the Emergency

(1943). Relaxation in the Emergency. The Journal of Health and Physical Education: Vol. 14, No. 1, pp. 7-51.
El Diablo: The Corner Cleaner Affair

This case involves the decision of a publishing company, El Diablo, to target a traditionally underserved market with a series of books about gang life and street vigilantism. The decision has repercussions both within the firm, as collegial relationships are tested by office politics, and outside the firm, where community response to the project is less than positive. Civil-rights groups challenge the company's development of pulp fiction targeted at black youths as unethical and likely to foment violence. The case raises several questions: Does a corporation owe a civic duty to its target constituents? How might that manifest itself? At the intersection of profit and responsibility, who has the right-of-way? Also, the hiring of a minority candidate by the minority director of the new-products division is questioned by top management. The use of role-playing is explained in the teaching note.
Sedimentation Aspects in Diversion at Old River

In recent years Old and Atchafalaya rivers have diverted increasing percentage of Mississippi River flow; observations have shown that distributary system is in state of imbalance in sediment transport capacity, which proves that flow capacity of Atchafalaya River can be expected to increase annually regardless of type of water year; tables and graphs show data on sediment transport and velocity relations.
Chariots of the Sun

Each man takes care that his neighbor shall not cheat him. But a day comes when he begins to care that he does not cheat his neighbor. Then all goes well -- he has changed his market-cart into a chariot of the sun. -Ralph Waldo Emerson The rule of law is essential to peace and economic growth. Unselfish behavior, in turn, may be essential to maintaining rule of law. Indeed, there is substantial empirical evidence to suggest that cultural habits of unselfish, prosocial behavior are correlated with economic prosperity at the national level. If this correlation reflects a causal link, the dominance of the homo economicus model in contemporary academic and policymaking circles may have serious and negative consequences for American society. Earlier Chapters developed a "three-factor" model that treats unselfish prosociality as socially-contingent behavior that responds to (1) instructions from authority; (2) perceptions that others are, or would, behave prosocially; and (3) the magnitude of the perceived benefits to others from one’s own unselfish prosocial actions. This approach suggests that widespread acceptance of the homo economicus assumption of rational self-interest can prove a "self-fulfilling prophecy" that induces people to behave more selfishly than they otherwise would - to our collective loss.
Rhesus and squirrel monkey placental specific antigen(s).

Rhesus and squirrel monkey placental antigens were fractionated on Sephadex G-100 columns and gave 3 peaks. The first fraction (molecular weight 100,000) migrated to the beta globulin area at the anode side of the well on immunoelectrophoresis, and leucine aminopeptidase activities were found in this fraction. Most of the gamma globulin of the serum and alkaline phosphatase was also found in this fraction. The second fraction (molecular weight 55,000) migrated to the alpha globulin areas. The third fraction (molecular weight 35,000) migrated to the cathode side of the well which contained no enzymatic activity. Fractions I and II were heat stable, with Fraction III less so. When labeled with fluorescein isothiocyanate, all 3 fractions located in the trophoblast. When further purified, Fraction III contained 11.2 mg. per milliliter of protein and 0.57 mg. per milliliter of carbohydrate. This fraction is nonhormonal, nonenzymatic, and probably a placental (trophoblast) specific protein. Antibodies to Fractions I and II of squirrel monkey placenta when used for passive immunization of pregnant squirrel monkeys had no effect, whereas antibodies to Fraction III resulted in immediate abortion.
Looking for coherence in science curriculum

Despite myriad attempts over the years to design curricula with logical ordering and connections, concerns persist that students view science as a body of prescribed information to memorize. In this essay, we argue that attempts to build coherence into the curriculum reflect fundamental and enduring misconceptions about the nature of coherence itself. Using examples of prominent curriculum projects over the past decade, we argue that premeditated coherence, the kind of coherence that is planned and designed for students, may inhibit students’ learning to seek coherence for themselves. We conclude with an approach to curriculum and assessment that emphasizes students’ epistemic agency in seeking coherence.
Improving extra-genital GC/CT screening among HIV-positive patients at the University of North Carolina Infectious Diseases clinic

Background Asymptomatic rectal and pharyngeal gonococcal (GC) and chlamydial (CT) infections are common among HIV-positive men who have sex with men (MSM) and women. However, screening for extra-genital gonococcal and chlamydial infections among HIV-positive patients is low. While urogenital screening is more common, this method may miss more than 70% of extra-genital infections among MSM and more than 15% of rectal infections among women.
Dissecting the Charlie Gard Case

The recent British case involving the infant Charlie Gard has generated considerable controversy. This piece offers my take on why the British courts were correct in their refusal to implement the parents' wishes to keep their desperately ill child alive.
Polarized Membrane Trafficking in Development and Disease: From Epithelia Polarization to Cancer Cell Invasion

Generation and maintenance of cell polarity is one of the most fundamental properties of multicellular organisms. Recent studies have started deciphering the mechanisms, and it is becoming clear that coordinated changes in the cytoskeleton and membrane transport dynamics are at the core of cellular polarization. In this review, we will describe the regulation and dynamics of this membrane transport and cytoskeleton interplay and will discuss the role of polarized membrane traffic in mediating epithelial cell polarization as well as formation of transient polarized structures, such as invadopodia, during cell migration.
Rawls on agreeing to disagree: How democracies differ from non-democracies in justifying war

We use Rawls’s account of public reason and the Law of Peoples to test two hypotheses: democracies are more likely to invoke self-defense in justifications than non-democracies, and democracies are...
Microbial contamination of non-household drinking water sources: a systematic review

Drinking water in non-household settings (e.g. schools, health care facilities (HCFs), restaurants, and mass gatherings) that is free of contamination is important for human health, especially in settings with vulnerable populations who are more at risk from the use of unsafe drinking water, such as immunocompromised patients in HCFs and children at school. Few studies have characterized water quality in non-household settings. We examined the quality of drinking water in non-household settings using studies identified through a previous systematic review. This review evaluated the quality ( E. coli , thermotolerant coliforms, and total coliforms) of drinking water in non-household settings. We found that drinking water in non-household settings is often non-compliant with health-based standards as defined by the World Health Organization. More research is necessary to determine the extent to which drinking-water quality in non-household settings differs from community settings to better understand how to effectively and appropriately address their challenges unique to safe water in non-household settings. This is of particular relevance to public health since people spend much of their day outside the home where they may consume unsafe water.
Anesthesia for Tracheoesophageal Fistula

Due to the advancement of prenatal and neonatal intensive care, patients with tracheoesophageal fistula (TEF) present with minimal respiratory distress and good lung compliance. Preoperative gastrostomy is rare and patients usually tolerate general anesthesia with muscle relaxant and gentle ventilation. Rigid bronchoscopy has become the standard procedure in many centers to identify the location and size of the fistula, to characterize airway anatomy and to place a Fogarty balloon catheter. Primary repair of TEF with either open thoracotomy or thoracoscopic surgery results in great outcomes. On the other hand, low birth weight (<1500 g) and associated complex cardiac anomalies are independent predictors of mortality after TEF repair with only a 27% survival rate. Invasive monitoring is indicated in patients with congenital heart disease, prematurity, poor pulmonary compliance, a large fistula, preoperative ventilatory compromised and those undergoing thoracoscopic repair. This chapter reviews multiple aspects of TEF including (1) Classification and clinical features. (2) Preoperative preparation and investigation. (3) Anesthetic management, especially airway management and intraoperative considerations. (4) Postoperative and long term complications. Table 39.1 summarizes the anesthesia plan with reasoning.
Managerial and Strategic Implications and Future Directions

This concluding chapter discusses the relationships across learning at different levels of analysis and across different dimensions of experience. Managerial and strategic implications of research findings on organizational learning are developed. The chapter concludes with a discussion of promising future research directions that are likely to advance our understanding of organizational learning.
The DDT Story: Environmentalism Over Rights to Health and Life

The insecticide DDT proved to be a potent tool in the control of insect vectors of human pathogens and directly led to the saving of many lives throughout the world during the middle of the 20th century. Reaction to environmental concerns over the use of DDT and other insecticides led to ban on the use of DDT. The cost-benefit outcome of this decision is discussed in light of the re-emergence of many vector-borne diseases over the last several decades.
Maximal d-Elements of an Algebraic Frame

The space of maximal d-ideals of C(X) is well-known and is widely studied. It is known that the space of maximal d-ideals is homeomorphic to the Z♯(X)-ultrafilters, and this space is the minimal quasi F-cover of a compact Tychonoff space X. In the current article we generalize this concept for M-frames, algebraic frames with the finite intersection property. In particular, we explore various properties of the maximal d-elements of a frame L, and their relation with the ultrafilters of $\mathfrak {K}L^{\perp }$ , the polars of the compact elements of L. On a separate note, we revisit the Lemma on Ultrafilters and establish the correspondence between the minimal prime elements spaces of L with the spaces of ultrafilters of $\mathfrak {K}L$ . Finally, we show that for complemented frames L, Min(L) = Max(dL), a result parallel to the one known for Riesz spaces, W-objects, and topological spaces.
Regulation of ATP-dependent chromatin remodelers: accelerators/brakes, anchors and sensors

All ATP-dependent chromatin remodelers have a DNA translocase domain that moves along double-stranded DNA when hydrolyzing ATP, which is the key action leading to DNA moving through nucleosomes. Recent structural and biochemical data from a variety of different chromatin remodelers have revealed that there are three basic ways in which these remodelers self-regulate their chromatin remodeling activity. In several instances, different domains within the catalytic subunit or accessory subunits through direct protein-protein interactions can modulate the ATPase and DNA translocation properties of the DNA translocase domain. These domains or subunits can stabilize conformations that either promote or interfere with the ability of the translocase domain to bind or retain DNA during translocation or alter the ability of the enzyme to hydrolyze ATP. Second, other domains or subunits are often necessary to anchor the remodeler to nucleosomes to couple DNA translocation and ATP hydrolysis to DNA movement around the histone octamer. These anchors provide a fixed point by which remodelers can generate sufficient torque to disrupt histone-DNA interactions and mobilize nucleosomes. The third type of self-regulation is in those chromatin remodelers that space nucleosomes or stop moving nucleosomes when a particular length of linker DNA has been reached. We refer to this third class as DNA sensors that can allosterically regulate nucleosome mobilization. In this review, we will show examples of these from primarily the INO80/SWR1, SWI/SNF and ISWI/CHD families of remodelers.
Managing Pain in Chronically Ill Homebound Patients Through Home-Based Primary and Palliative Care

Background:Many older adults are homebound due to chronic illness and suffer from significant symptoms, including pain. Home-based primary and palliative care (HBPC), which provides interdisciplina...
Methodology for Mechanistic Design of Pervious Concrete Pavements

AbstractPervious concrete pavements (PCP) are used as pavement structures that serve as stormwater drainage systems. However, as opposed to the hydrological design, structural evaluation and layer ...
Adolescent Temperament, but Not Age or Gender, Is Associated with Parental Socialization of Positive Affect

Parents are a critical influence on adolescents’ expressions of positive affect (PA; happiness, excitement), which are important components of adaptive emotional development during this developmental period. Despite a recent proliferation of studies examining outcomes of parental response to PA, limited research has explored unique adolescent characteristics that relate to parents’ specific responses to adolescent PA. Thus, the current study examined the contribution of specific adolescent characteristics (temperament, age, and gender) on dampening and enhancing responses to PA. Parents (n= 371, 49.6% mothers) of adolescents between ages 10 and 17 years (Mage = 13.5 years, 46.4% female) recruited thru Amazon Mechanical Turk completed a series of questionnaires on their offspring’s temperament and their enhancing and dampening responses to youth PA. Over and above parental age and gender, parent-reported adolescent positive emotionality and effortful control were uniquely related to dampening responses; however, all temperament dimensions were unrelated to enhancing responses. Adolescent age and gender were unrelated to parental PA socialization and did not moderate links between parent-reported temperament and parental dampening responses; however, there was a significant three-way inter action for temperament, age and gender for parental enhancing responses. Overall the findings suggest that adolescents low in effortful control and positive emotionality elicit more parental dampening responses to PA. Future research is needed to clarify the factors that contribute to parents’ enhancing of PA.
Power Lower Bounds for the Central Moments of the Last Passage Time for Directed Percolation in a Thin Rectangle

In directed last passage site percolation with i.i.d.~random weights with finite support over a $n\times\lfloor n^{\alpha}\rfloor$ grid, we prove that for $n$ large enough, the order of the $r$-th central moment, $1\le r<+\infty$, of the last passage time is lower bounded by $n^{r(1-\alpha)/2}$, $0<\alpha<1/3$.
Unraveling Gibbsite Transformation Pathways into LiAl-LDH in Concentrated Lithium Hydroxide.

Gibbsite (α-Al(OH)3) transformation into layered double hydroxides, such as lithium aluminum hydroxide dihydrate (LiAl-LDH), is generally thought to occur by solid-state intercalation of Li+, in pa...
Utilizing HAZUS and PACER SURGE to map and characterize hospitals in Illinois within the New Madrid seismic zone

Abstract Purpose To highlight the need for utilizing disaster software to aid hospitals for disaster preparedness, specifically an earthquake occurring in the New Madrid Seismic Zone (NMSZ). The NMSZ is an active fault in central United States that is currently at a relatively high risk of experiencing a significant earthquake within the next 50 years. Results Using the HAZUS mapping software, 40 healthcare facilities in Illinois were identified that fall within the NMSZ. Using the National Center for the Study of Preparedness and Catastrophic Event Response (PACER) SURGE software, it was determined that those healthcare facilities have a surge capacity of 272 people. Discussion Healthcare facilities could benefit from preparing more for high likely disaster events, such as an earthquake in the NMSZ. A surge capacity of 272 people only accounts for a very small percentage of the population of this area, and it therefore may be important to increase hospital capacity for such an event. Hospitals can also invest in improving their infrastructure to reduce damages and potential loss of life.
Differentially closed fields

This article provides several definitions and results involving differential fields, with references for proofs but with few proofs. No new results appear here; rather the attempt has been made to display information in the setting in which it is needed in order to make the account in this volume self contained in terms of definitions, notation, and results. The reader seeking more details should refer to Marker’s and Pillay’s articles [Mar 96], [Pil 96].
Selling the Need for School Social Work Services to the Legislature: A Call for Advocacy.

Recent attempts to marginalize the social work profession have had an impact on school social workers in New Mexico. To better understand the quality of the workplace for these related services professionals, a past lead social worker for a large school district was interviewed, and three open-ended items were added to the 2010 statewide school social work survey. Responses from sixty-four school social workers across the state are presented. The questions focused on the impact of the economy, rising caseloads and attrition, and concerns about the future. Results indicate that school social workers here feel overworked and unsure and fearful about the future. Important historical information sheds light on the process of obtaining a three-tier pay schedule for school social workers and the potential legislative challenges to their work in the public schools. An interdisciplinary advocacy process model is presented that will identify and promote the need for school social workers to the New Mexico Legislature. The advocacy process and the development of a Senate joint memorial that emphasizes interdisciplinary collaboration on practice outcome evaluation are discussed within the context of growing concerns about the economy and the future of related service providers in the state’s public education system.
The evolving role of interventional cardiology in the treatment of pulmonary hypertension.

Pulmonary hypertension (PH) is a heterogeneous group of diseases defined by a mean pulmonary arterial pressure greater than 20 mmHg. Clinically, PH is classified into five groups and the group of PH generally defines the cause of PH and the therapeutic options. Currently, medical therapies that target the prostacyclin, endothelin, and nitric oxide pathways are used in pulmonary arterial hypertension and chronic thromboembolic PH (CTEPH) patients. Moreover, surgery can improve outcomes in PH as pulmonary thromboendarterectomy can be curative for CTEPH and lung transplantation is used for end-stage PH. Despite these diverse treatment options, PH patients continue to have high symptom burden and poor long-term outcomes. However, advances in percutaneous technology are opening new avenues for the management of PH. In this review, we discuss the available data supporting the use of four interventional procedures: balloon atrial septostomy, transcatheter Potts shunt, balloon pulmonary angioplasty, and pulmonary artery denervation for the treatment of PH. These procedures provide hemodynamic and functional improvements in PH patients, but they come with their own unique risk profiles. Hopefully, these procedures will continue to be refined and thereby provide a venue for interventional cardiology to safely and effectively improve outcomes for PH moving forward.
Adverse Events Associated with Implantable Dopplers during Microvascular Surgery.

Background Implantable Dopplers (IDs) are widely used for postoperative free flap vascular monitoring. However, IDs may contribute to free flap complications or failure and better understanding of device malfunctions is needed. Methods The U.S. Food and Drug Administration's Manufacturer and User Facility Device Experience database was queried for all reports of ID adverse events from two leading manufacturers (Cook Vascular and Synovis Life Technologies) in free flap surgery from January 2010 to March 2020. Reports were reviewed and categorized. A comparison of reoperations within select categories was performed using Chi-square analysis. Results Of 209 included reports, the most common device malfunctions were venous anastomotic coupler misalignment (35.4%) and coupler ring detachment (24.4%). Synovis devices were used in 100% of reports of vessel compression and Cook Vascular devices were used in 77.7% of reports of probe detachment. Of 74 patient-related adverse events, the most common were reoperation (47.3%) and vessel occlusion (28.4%). Of five reported events of flap failure, two were associated with loss of ID signal. The proportion of Doppler signal loss events leading to reoperation was significantly greater than the proportion of any other Doppler-related event leading to reoperation. Intraoperative coupler replacement was the most commonly reported intervention (n = 86), and venous anastomosis with hand-suturing occurred in 30 device malfunctions. Conclusion This study demonstrates a variety of ID-related malfunctions. One-third of device malfunctions were associated with patient complications, and false-positive Doppler signal loss contributed substantially to the requirement of surgical re-exploration. These are important considerations for surgical teams utilizing IDs in free tissue transfer procedures.
Versatile Trajectory Optimization Using a LCP Wheel Model for Dynamic Vehicle Maneuvers

Car models have been extensively studied at varying levels of abstraction, and planning and executing motions under ideal conditions is well researched and understood. For more aggressive maneuvers, for example when drifting or skidding, empirical and/or discontinuous friction models have been used to explain and approximate real world contact behavior. Separately, contact dynamics have been extensively studied by the robotics community, often times formulated as a linear complementarity problem (LCP) for dynamic multi-rigid-body contact problems with Coulomb friction cone approximations. In this work, we explore the validity of using such an anisotropic Coulomb friction cone to model tire dynamics to plan for vehicle motion, and present a versatile trajectory optimization framework using this model that can both avoid and/or exploit wheel skidding, depending on the cost function and planning horizon. Experimental evidence of planning and executing dynamic drift parking is shown on a 1/16 scale model car.
Point-of-Care Ultrasound Used to Distinguish Between Superficial Skin Abscess and Deep Mediastinal Abscess: A Case Report

Abstract Background Skin and soft tissue infections (SSTIs) are an increasingly common complaint in the emergency department (ED), but physical examination does not reliably identify abscesses or accurately determine which skin lesions require incision and drainage. Point-of-care ultrasound (POCUS) improves management of soft tissue skin infections by detecting occult abscess, preventing unnecessary procedures, and identifying more complex disease requiring further imaging. Case Report Here, we report a case in which POCUS drastically changed the management of what initially appeared to be an uncomplicated superficial skin abscess but was actually a much more serious mediastinal infection. Why Should an Emergency Physician Be Aware of This? This case underscores the importance and utility of POCUS to enhance the physical examination in suspected SSTIs. Because POCUS is easy, accurate, low risk, and can change management, we recommend its consideration as a standard component of the ED work up for SSTIs.
Non-Uniform Distribution of Cryoprotecting Agents in Rice Culture Cells Measured by CARS Microscopy

Cryoprotectants allow cells to be frozen in liquid nitrogen and cryopreserved for years by minimizing the damage that occurs in cooling and warming processes. Unfortunately, how the specific cryoprotectants keep the cells viable through the cryopreservation process is not entirely evident. This contributes to the arduous process of optimizing cryoprotectant formulations for each new cell line or species that is conserved. Coherent anti-Stokes Raman scattering microscopy facilitates the visualization of deuterated cryoprotectants within living cells. Using this technique, we directly imaged the location of fully deuterated dimethyl sulfoxide (d6-DMSO), the deuterated form of a commonly used cryoprotectant, DMSO, within rice suspension cells. This work showed that d6-DMSO does not uniformly distribute throughout the cells, rather it enters the cell and sequesters within organelles, changing our understanding of how DMSO concentration varies within the cellular compartments. Variations in cryoprotectant concentration within different cells and tissues will likely lead to differing protection from liquid nitrogen exposure. Expanding this work to include different cryoprotectants and mixtures of cryoprotectants is vital to create a robust understanding of how the distributions of these molecules change when different cryoprotectants are used.