cssi/SciSciGPT-SciSciNet huggingface dataset:
Neurologic outcome after ascending aorta–aortic arch operations: Effect of brain protection technique in high-risk patients

Objective: We sought to assess the optimal strategy for avoiding neurologic injury after aortic operations requiring hypothermic circulatory arrest. Methods: All 717 patients who survived ascending aorta–aortic arch operations through a median sternotomy since 1986 were examined for factors influencing stroke. Temporary neurologic dysfunction was assessed in all patients who survived the operation without stroke since 1993. Multivariate analyses were carried out to determine independent risk factors for neurologic injury. Results: Independent risk factors for stroke were as follows: age greater than 60 years (P <.001; odds ratio, 4.5); emergency operation (P =.02; odds ratio, 2.2); new preoperative neurologic symptoms (P =.05; odds ratio, 2.9); presence of clot or atheroma (P <.001; odds ratio, 4.4); mitral valve replacement or other concomitant procedures (P =.055; odds ratio, = 3.7); and total cerebral protection time, defined as the sum of hypothermic circulatory arrest and any retrograde or antegrade cerebral perfusion (P =.001; odds ratio, 1.02/min). In 453 patients surviving operations without stroke after 1993, independent risk factors for temporary neurologic dysfunction included age (P <.001; odds ratio, 1.06/y), dissection (P =.001; odds ratio, 2.2), need for coronary artery bypass grafting (P =.006; odds ratio, 2.1) or other procedures (P =.023; odds ratio, 3.4), and total cerebral protection time (P <.001; odds ratio, 1.02/min). When all patients with total cerebral protection times between 40 and 80 minutes were examined, the method of cerebral protection did not influence the occurrence of stroke, but antegrade cerebral perfusion resulted in a significant reduction in incidence on temporary neurologic dysfunction (P =.05; odds ratio, 0.3). Conclusions: The occurrence of stroke is principally determined by patient- and disease-related factors, but use of antegrade cerebral perfusion can significantly reduce the occurrence of temporary neurologic dysfunction. (J Thorac Cardiovasc Surg 2001;121:1107-21)
What can plants do for cell biology

Historically, cell biologists studied organisms that represented a reasonable sampling of life's diversity, whereas recently research has narrowed into a few model systems. As a result, the cells of plants have been relatively neglected. Here I choose three examples to illustrate how plants have been informative and could be even more so. Owing to their ease of imaging and genetic tractability, multicellular plant model systems provide a unique opportunity to address long-standing questions in cell biology.
Automated gland and nuclei segmentation for grading of prostate and breast cancer histopathology

Automated detection and segmentation of nuclear and glandular structures is critical for classification and grading of prostate and breast cancer histopathology. In this paper, we present a methodology for automated detection and segmentation of structures of interest in digitized histopathology images. The scheme integrates image information from across three different scales: (1) low- level information based on pixel values, (2) high-level information based on relationships between pixels for object detection, and (3) domain-specific information based on relationships between histological structures. Low-level information is utilized by a Bayesian classifier to generate a likelihood that each pixel belongs to an object of interest. High-level information is extracted in two ways: (i) by a level-set algorithm, where a contour is evolved in the likelihood scenes generated by the Bayesian classifier to identify object boundaries, and (ii) by a template matching algorithm, where shape models are used to identify glands and nuclei from the low-level likelihood scenes. Structural constraints are imposed via domain- specific knowledge in order to verify whether the detected objects do indeed belong to structures of interest. In this paper we demonstrate the utility of our glandular and nuclear segmentation algorithm in accurate extraction of various morphological and nuclear features for automated grading of (a) prostate cancer, (b) breast cancer, and (c) distinguishing between cancerous and benign breast histology specimens. The efficacy of our segmentation algorithm is evaluated by comparing breast and prostate cancer grading and benign vs. cancer discrimination accuracies with corresponding accuracies obtained via manual detection and segmentation of glands and nuclei.
Reshaping the Past: Gorky's Reminiscences of Korolenko

Although not as well-known as his memoirs of Tolstoy, Chekhov, and Andreev, Gorky's two essays devoted to Korolenko are of no less interest. First, like some of Gorky's other works that draw on his life experiences, they show clear evidence of artistic reworking: he is not beyond playing with the chronology and introducing certain elements to reshape his memories into effective narratives. The existence of a third item on Korolenko, a speech that Gorky gave in 1918, provides comparative data that helps reveal the artistic embellishment in the two later works. Second, these two pieces straddle the boundary between memoir and autobiography, both in terms of content and within the context of Gorky's career. He composed them in 1922, just three years after he initially published his memoirs of Tolstoy and Andreev; like those works and others devoted to a single prominent figure, the writings on Korolenko seemingly belong to the category of memoir. However, they begin with the period that immediately follows the final events in the third part of his autobiographical trilogy, My Universities, which was written at about the same time, and so can also be regarded as a continuation of that work. Third, his relationship with Korolenko is of intrinsic interest. Their first meetings go back to Gorky's literary beginnings and so offer some insights into his early steps as a writer and Korolenko's role in those. In more subtle ways, the two essays also reflect aspects of an epistolary exchange between the writers toward the very end of Korolenko's life and contain a veiled critique of the social and political atmosphere of the post-Revolutionary years.
Characterization of monolayer and organ cultures of cloned and enriched lymphohematopoietic stromal cell populations

The role of hematopoietic microenvironments in the regulation of maturation and differentiation of hematopoietic cells, although heavily debated, remains uncertain. Several investigators have suggested that the adherent “stromal” cell populations, which grow as colonies in cultures of lymphomyeloid tissues, include the cells involved in such regulatory processes. Grossly, the colonies described by several investigators appear similar morphologically, and the cells giving rise to them have been variously termed (1) fibroblast colony forming cells (FCFC), (2) plaque forming units-culture (PFU-C), (3) macrophage colonies, and (4) marrow stromal cells. FCFC have been reported to re-establish their parent microenvironment when transplanted in an allogeneic system. In this study, cloned and enriched cell populations obtained from such colonies in cultures of murine lymphomyeloid tissues have been characterized by their growth in culture and using morphological, histochemical, and electron microscopic techniques. The results demonstrated that, although the initial stromal colonies appeared to be identical, the constituent cell types varied considerably. Some colonies were comprised primarily of macrophages, while others appeared to contain predominantly fibroblasts; two additional cell types that established colonies have not yet been satisfactorily identified. These results demonstrate the heterogeneity of lymphomyeloid stromal colonies. There is a need for caution in the analysis of experiments in which uncharacterized stromal cell colonies are transplanted or employed as supporting monolayers in culture systems in experiments designed to evaluate the origins and functions of lymphohematopoietic stroma.
Using Remember the Titans to Teach Theories of Conflict Reduction

One of the benefits of using films in sociology class is the opportunity media representations give students to "experience" situations that are uncommon in their daily lives. In this note the authors outline research in education that demonstrates the role of imagery and experiential learning in fostering a deeper understanding of material for students. They then focus on the ability of one film (Remember the Titans) to transport students to a place they will never experience—racially charged 1971 Virginia—and to illustrate social psychological processes of conflict reduction (contact, superordinate goals, and shared identities) as well as the link between micro-interaction, social institutions, and larger patterns of social stratification. After elaborating how the authors have used the film in class, they present findings from their students that demonstrate the effectiveness of the film for enhancing student understanding.
Evaluations of patient education programs: a meta-analysis.

A literature search located 23 evaluations of patient education programs that utilized a randomly selected control group (i.e., an experimental design) or a non- equivalent control group (i.e., a quast experimental design). Meta-analysis pro cedures were used to combine the findings of these studies The effect size for each of 102 dependent variables was derived from the mean of an experimental group and the mean and standard deviation of an untaught control group. The effect size is a z-score that can be converted into the mean percentile rank of taught pattents relative to the untaught controls The mean effect size for all studies was .74, which is equivalent to improving the average taught patient from the fiftieth to the seventy-seventh percentile relative to the untaught patient group Suggestions for improving the usefulness of patient education research design and report content are discussed
An interior penalty method for inequality constrained optimal control problems

This paper presents a penalty function approach to the solution of inequality constrained optimal control problems. The method begins with a point interior to the constraint set and approaches the optimum from within, by solving a sequence of problems with only terminal conditions as constraints. Thus, all intermediate solutions satisfy the inequality constraints. Conditions are given which guarantee that the un "constrained" problems have solutions interior to the constraint set and that in the limit these solutions converge to the constrained optimum. For linear systems with convex objective and concave inequalities, the unconstrained problems have the property that any local minimum is global. Further, under these conditions, upper and lower bounds in the optimum are easily available. Three test problems are solved and the results presented.
A performance analysis of PIM, stream processing, and tiled processing on memory-intensive signal processing kernels

Trends in microprocessors of increasing die size and clock speed and decreasing feature sizes have fueled rapidly increasing performance. However, the limited improvements in DRAM latency and bandwidth and diminishing returns of increasing superscalar ILP and cache sizes have led to the proposal of new microprocessor architectures that implement processor-in- memory, stream processing, and tiled processing. Each architecture is typically evaluated separately and compared to a baseline architecture. In this paper, we evaluate the performance of processors that implement these architectures on a common set of signal processing kernels.The implementation results are compared with the measured performance of a conventional system based on the PowerPC with Altivec. The results show that these new processors show significant improvements over conventional systems and that each architecture has its own strengths and weaknesses.
GPS as a Method for Assessing Spatial and Temporal Use Distributions of Nature-Based Tourists:

Traditional methods of collecting spatial and temporal use data are burdensome to both tourists and researchers, and they often lack needed accuracy. This article examines emergent GPS technology and its application to tracking nature-based tourists. Two applications of GPS presented here demonstrate the usefulness and functionality of GPS for tracking nature-based tourists in most natural recreation environments and in open, complex systems. This study finds that GPS offers advantages over traditional methods for tracking visitors, including more reliable, accurate, and precise data. GPS makes measuring and understanding visitor use patterns even more valuable since actual movements can be investigated instead of reported movements. Also, the accuracy and detail of GPS-collected data allow for analyses and investigations not otherwise possible. Visitor-based GPS surveys represent a useful and potentially powerful tool to help better plan, manage, and monitor nature-based tourists.
A teologia entre a ciência e a poesia

No painel de sintese, no fim da Semana Teologica, docentes da EST — Wanda Deifelt, Oneide Bobsin, Manfredo C. Wachs e Christoph Schneider-Harpprecht — reagiram as proposicoes que vieram dos outros saberes, ora questionando e complementando, ora sintetizando. Wanda Deifelt pergunta se a teologia e ciencia ou poesia, e racional ou subjetiva.
Assisted Reproductive Technology: A Look at the Disposition of Embryos in Divorce

The increased use of assisted reproductive technology over the past decade in order to overcome infertility problems has created some unexpected legal problems in the family law field. One of these problems is the growing storage of unused surplus embryos which were originally created for use in the process of in vitro fertilization, but were not used. When a married couple has created these unused embryos but are now in the process of getting divorced, disagreements sometimes arise about how to dispose of the embryos. Courts have not found a common solution to the resolution of such disputes. The authors identify four different solutions by different courts to resolve conflicts of this sort in the context of divorce. They believe that it is unlikely that a uniform answer to the problem will be found in the near future, and urge courts and lawyers to carefully review the different approaches found in the reported case law to devise the best solution which fits the facts of a particular case.
Genetically targeted magnetic control of the nervous system

Optogenetic and chemogenetic actuators are critical for deconstructing the neural correlates of behavior. However, these tools have several limitations, including invasive modes of stimulation or slow on/off kinetics. We have overcome these disadvantages by synthesizing a single-component, magnetically sensitive actuator, "Magneto," comprising the cation channel TRPV4 fused to the paramagnetic protein ferritin. We validated noninvasive magnetic control over neuronal activity by demonstrating remote stimulation of cells using in vitro calcium imaging assays, electrophysiological recordings in brain slices, in vivo electrophysiological recordings in the brains of freely moving mice, and behavioral outputs in zebrafish and mice. As proof of concept, we used Magneto to delineate a causal role of striatal dopamine receptor 1 neurons in mediating reward behavior in mice. Together our results present Magneto as an actuator capable of remotely controlling circuits associated with complex animal behaviors.
Wing Traps Baited with Male Boll Weevils for Determining Spring Emergence of Overwintered Weevils and Subsequent Infestations in Cotton

When wing traps baited with male Anthonomus grandis Boheman were placed around small cotton fields in a ratio of 1 trap per 2 to 3 acres, a positive correlation was found between the number of overwintered weevils captured and the number observed in the field. However, the estimate obtained by sampling the number of weevils hibernating in woods trash did not correlate with the number captured or observed. The location of traps in relation to overwintering sites influenced the captures on the traps, and time of entry of weevils into the fields appeared to be related to the beginning of fruiting by the cotton.
ASHP guidelines on the pharmacist's role in providing drug information.

The provision of drug information (DI) is among the fundamental professional responsibilities of all pharmacists. Recent practice trends, including increased provision of medication therapy management services and efforts to obtain provider status, have placed pharmacists in increasingly complex
Composting and Evaluating a Pulp and Paper Sludge for Use as a Soil Amendment/Mulch

Composting could be used in the pulp and paper industry to treat primary sludges as an alternative to landfilling. The objective of this project was to compost and evaluate a pulp and paper sludge for use as a soil amendment/mulch. Primary sludge, tailings, wood ash (0, 5 or 10 percent by volume), and paunch (cattle stomach contents and tissue) from a slaughterhouse were composted in a 91 m windrow that was turned one to two times per week. The pile moisture content and temperature were controlled at 50 percent and 57–63°C during 14 weeks of composting. The compost was then cured for 4 weeks for a total treatment time of 18 weeks. Sludge dry mass decreased by approximately 50 percent, pH increased slightly to 8.2 to 8.5, and carbon-nitrogen ratio decreased from 270:1 to 14–67:1 after composting and curing. Electrical conductivity of all final composts was over 4 dS/m. Shoot biomass of tomato plants grown in a compost-amended medium (50 percent compost, 25 percent sand, 25 percent perlite by volume) improv...
Employee Benefits and Workers in the Nonprofit Sector

Employee Benefit Research Institute analysis of the March 1996 Current Population Survey (CPS) indicates that employee benefits, such as health insurance and pension plans, vary significantly across workers employed in different sectors of the economy. Workers employed in the nonprofit sector are more likely to receive employee benefits in the form of health insurance and pension plans than their counterparts in the for-profit sector. Worker attributes play a strong role in explaining the employee benefits differential.
Pater’s Auxerre Tapestry

My title refers to an art object that does not actually exist, but rather lives only in the text of Pater’s imaginary portrait, ‘Denys L’Auxerrois’. The set of medieval tapestries that the narrator discovers in the French river-town of Auxerre tells the story of Denys, a story in turn that Pater’s narrator represents in his own words. As such, Pater’s portrait belongs to the long tradition of literary texts that represent purely fictional works of visual art, what John Hollander has called ‘notional’ ekphrasis (1995, pp. 7–32).We might say that Pater’s tapestry is radically notional, for he provides little specific description of what the woven images look like, nor of the tapestry’s overall design. Indeed, as we read the story of Denys, the ekphrastic encounter seemingly falls away. Yet, the startling final sentences of the portrait remind us that we have been reading a translation of image into word, an act of intense imaginative energy by which the narrator seemingly transforms the lifeless Denys into a living creature who walks the rainy streets of the late nineteenth century. This framing device, the ekphrastic episode contained within a narrative detailing both an encounter with visual images and the effects of that encounter, is central to the classical tradition of notional ekphrasis, from Aeneas’s reading of the wall murals on the temple of Juno, to Dante’s encounter with the carved figures on the terrace of Pride in the Purgatorio, to Chaucer’s rereading of Aeneas’s tale in The House of Fame, and running throughout the history of Western literature. In dramatizing the act of interpreting visual art, narratively framed ekphrases of notional images highlight the metatextual potential of all ekphrasis. Pater’s portrait follows in this tradition, dramatizing the act of interpreting visual art and translating images into words.
Wide-area measurement data analytics using FNET/GridEye: A review

With the increasing size and complexity of the power grid, wide-area measurement system (WAMS) has been studied and implemented more widely. As a pioneering WAMS deployed at the distribution level, the frequency monitoring network FNET/GridEye has been providing independent observation of dynamic performance of U.S. and other worldwide power grids continuously since 2004. By utilizing GPS-time-synchronized monitors called frequency disturbance recorders (FDRs), FNET/GridEye is capable to capture dynamic grid behaviors (e.g., frequency and voltage phase angle). Compared to the three-phase phasor measurement units (PMUs), the FDRs can be conveniently deployed across the grid at distribution level without complex procedure and heavy outlay. With years' continuous development and systematic management, FNET/GridEye has thrived with multiple advanced online and offline applications. The system has been proved to be highly effective in enhancing power grid operators' situational awareness capabilities. In this paper, the latest accomplishments of FNET/GridEye will be introduced.
Legacy lead arsenate soil contamination at childcare centers in the Yakima Valley, Central Washington, USA.

Abstract Background From the early 1900s to the 1950s, Yakima Valley orchards were commonly treated with lead arsenate (LA) insecticides. Lead (Pb) and arsenic (As) soil contamination has been identified on former orchard lands throughout Central Washington and pose a threat to human health and the environment. Objectives The levels of Pb and As in soil and interior dust at participating childcare centers in the Upper Yakima Valley (Yakima County), Washington were sampled to explore exposure potential for young children. Methods Childcare center soils were collected from two soil depths, homogenized, and analyzed in bulk by a field-portable X-ray fluorescence spectrometer (XRF). Interior dust wipes samples were collected from at least two locations in each facility. All soil samples >250 mg/kg Pb and/or >20 As mg/kg were sieved to 250 μm, tested by XRF a second time, and analyzed via acid digestion and inductively coupled plasma mass spectrometry (ICP-MS) analysis. Results Bulk and sieved XRF results, as well as ICP-MS to XRF results were strongly correlated. Maximum Pb and As XRF results indicated that 4 (21%) and 8 (42%) of the 19 childcare centers surveyed exceeded the regulatory standard for Pb and As, respectively. Historic land use was significantly associated with elevated Pb and As levels. Interior dust loadings were below United States Environmental Protection Agency (EPA) guidelines. Conclusions Childcare centers are areas of intensive use for children and when coupled with potential residential exposure in their homes, the total daily exposure is a potential hazard to children.
Cardiac myofibrillar contractile properties during the progression from hypertension to decompensated heart failure.

This novel study systematically examined the power-generating capacity of cardiac myofilaments during the progression from hypertension to heart disease. Previously undiscovered changes in myofibri...
ETF Short Interest and Failures-to-Deliver: Naked Short-Selling or Operational Shorting?

We identify an alternative source of ETF shorting related to the market maker liquidity provision and creation/redemption activities. Unlike “directional shorting” used for informational or hedging purposes, liquidity-driven “operational shorting” arises due to a regulatory exemption which allows ETF market makers to satisfy excess demand in secondary markets by selling ETF shares that have not yet been created. We find that operational shorting is associated with improved liquidity and greater price efficiency in the underlying securities held by an ETF. Higher retail trading activity and short-term ETF return reversals are also consistent with liquidity-supplying motives rather than informed trading. Consequently, delayed ETF creation to cover operational shorts results in failures to deliver and is found to be a valuable option in the presence of retail trading and liquidity mismatches between the ETF and its underlying securities. Commonality in operational shorting across lead market makers can lead to increased counterparty risk and we find that financial leverage can amplify these inter-dealer relationships.
Arc flash mitigation initiatives in data centers electrical substations: A case study

Data Centers' continuous operation is crucial to business continuity as these centers are usually hosting company's important systems and services. Companies' and services' owners strive to balance between the required reliability and redundancy level to efficiently manage their businesses. Thus, data center maintenance becomes a vital task for data center managers, to ensure achieving equipment maximum performance and reliability level. These maintenance tasks — which encompass many breakers' switching activities for high voltage and low voltage electrical systems — will expose operators to a high risk of an arc flash incident, where rapid release of electrical energy will occur, due to arcing fault between electrical phases, neutral or ground, resulting in extremely high temperature, a powerful pressure blast, and shrapnel hurling at very high velocity. This paper will discuss the calculated arc flash energy levels in one of the largest data centers in Saudi Arabia, and the implemented mitigation techniques: installation of permanent thermal infrared (IR) sensors in critical electrical joints to properly identify any loose joints at an early stage (30% loading), prior to stressing them during maintenance switching activity; installation of arc flash maintenance switches in Low-Voltage breakers, to minimize the arc fault clearing time, through instantaneously operating the protection devices in those breakers; and remote switching via the site Electrical Power Management System (EPMS), to ensure keeping the operators at a safe working distance away from the arc flash hazards. The outcome of this paper is to share the arc flash levels before and after the implementation of the mitigation techniques, as well as the details of implementing these initiatives.
ResourceSync: The NISO/OAI Resource Synchronization Framework

This tutorial provides an overview and a practical introduction to ResourceSync, a web-based synchronization framework consisting of multiple modular capabilities that a server can selectively implement to enable third party systems to remain synchronized with the server’s evolving resources. The tutorial motivates the ResourceSync approach by outlining several synchronization use cases including scholarly article repositories, OAI-PMH repositories, linked data knowledge bases, as well as content aggregators. It details the concepts of the ResourceSync capabilities, their discovery mechanisms, and their serialization based on the widely adopted Sitemap protocol. The tutorial further hints at the extensibility of the synchronization framework, for example, for scenarios to provide references to mirror locations of synchronization resources, to transferring partial content, and to offering historical data.
Wanted: programming support for ensuring responsiveness despite resource variability and volatility

variability in response time, software frameworks, futures, concurrency, multi-threading, multi-resolution, incremental quality of service, dynamic resource allocation, prioritization, task garbage collection, mobile computing, Petra-Flow Applications running in networked mobile computing environments are prone to a great deal of variability in the response time they experience from system services, such as an (implicitly distributed) file system or (explicit) networking. The range of variability is much greater than in traditional computing environments and changes dynamically. Without special programming considerations, such applications will exhibit unacceptable user responsiveness when resources are slow.
Two Examples of Application of Optoelectronic Analytical Techniques in AMO Systems

Sometimes, similarities between underlying physics allow optoelectronic-device calculational techniques to be used in AMO problems. This talk presents two examples: (a) atomtronics (devices based on Bose-Einstein condensation), (b) T 2 in NV centers in diamond.
Relative contribution of modifiable risk factors for incident atrial fibrillation in Hispanics, African Americans and non-Hispanic Whites.

Abstract Background Contribution of modifiable risk factors for the risk of new onset atrial fibrillation (AF) in minority populations is poorly understood. Our objective was to compare the population attributable risk (PAR) of various risk factors for incident AF between Hispanic, African American and non-Hispanic Whites. Methods An ECG/EMR database was interrogated for individuals free of AF for development of subsequent AF from 2000 to 2013. Cox regression analysis controlled for age > 65, male gender, body mass index > 40 kg/m2, systolic blood pressure > 140 mm Hg, diabetes mellitus, heart failure, socioeconomic status less than the first percentile in New York State, and race/ethnicity. PAR was calculated as (prevalence of X) ∗ (HR − 1)/HR, where HR is the hazard ratio, and X is the risk factor. Results 47,722 persons free of AF (43% Hispanic, 37% Black and 20% White) were followed for subsequent incident AF. Hypertension in African Americans and Hispanics had a 7.93% and 7.66% greater PAR compared with non-Hispanics Whites. Similar findings existed for the presence of heart failure, with a higher PAR in non-Whites compared to Whites. Conclusion In conclusion, modifiable risk factors play an important role in the risk of incident AF. Higher PAR estimates in African Americans and Hispanics were observed for elevated systolic blood pressure and heart failure. Identification of these modifiable risk factors for atrial fibrillation in non-White minorities may assist in targeting better prevention therapies and planning from a public health perspective. No funding sources were used for this study.
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

While radioimmunotherapy (RIT) is a promising approach for the treatment of cancer, the long pharmacokinetic half-life of radiolabeled antibodies can result in high radiation doses to healthy tissues. Perhaps not surprisingly, several different strategies have been developed to circumvent this troubling limitation. One of the most promising of these approaches is pretargeted radioimmunotherapy (PRIT). PRIT is predicated on decoupling the radionuclide from the immunoglobulin, injecting them separately, and then allowing them to combine in vivo at the target tissue. This approach harnesses the exceptional tumor-targeting properties of antibodies while skirting their pharmacokinetic drawbacks, thereby lowering radiation doses to non-target tissues and facilitating the use of radionuclides with half-lives that are considered too short for use in traditional radioimmunoconjugates. Over the last five years, our laboratory and others have developed an approach to in vivo pretargeting based on the inverse electron-demand Diels-Alder (IEDDA) reaction between trans-cyclooctene (TCO) and tetrazine (Tz). This strategy has been successfully applied to pretargeted positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging with a variety of antibody-antigen systems. In a pair of recent publications, we have demonstrated the efficacy of IEDDA-based PRIT in murine models of pancreatic ductal adenocarcinoma and colorectal carcinoma. In this protocol, we describe protocols for PRIT using a 177Lu-DOTA-labeled tetrazine radioligand ([177Lu]Lu-DOTA-PEG7-Tz) and a TCO-modified variant of the colorectal cancer targeting huA33 antibody (huA33-TCO). More specifically, we will describe the construction of huA33-TCO, the synthesis and radiolabeling of [177Lu]Lu-DOTA-PEG7-Tz, and the performance of in vivo biodistribution and longitudinal therapy studies in murine models of colorectal carcinoma.
Pharmaceutical Creep: U.S. Military Power and the Global and Transnational Mobility of Psychopharmaceuticals

In 2006, the United States Department of Defense developed for the first time official criteria for the use of psychopharmaceuticals "in theater"-in the physical and tactical spaces of military operations including active combat. Based on fieldwork with Army soldiers and veterans, this article explores the transnational and global dimensions of military psychopharmaceutical use in the post-9/11 wars. I consider the spatial, material, and symbolic dimensions of what I call "pharmaceutical creep"-the slow drift of psychopharmaceuticals from the civilian world into theater and into the military corporate body. While pharmaceutical creep is managed by the U.S. military as a problem of gatekeeping and of supply and provisioning, medications can appear as the solution to recruitment and performance problems once in theater. Drawing on soldiers' accounts of medication use, I illuminate the possibilities, but also the frictions, that arise when routine psychopharmaceuticals are remade into technologies of global counterinsurgency.
A Portalino to the Twin Sector

Extensions of the Standard Model are often highly constrained by cosmology. The presence of new states can dramatically alter observed properties of the universe by the presence of additional matter or entropy. In particular, attempts too solve the hierarchy problem through naturalness invariably predict new particles near the weak scale which come into thermal equilibrium. Without a means to deposit this energy into the SM, these models are often excluded. Scenarios of "neutral naturalness" especially, such as the Twin Higgs frequently suffer from this. However, the Portalino, a singlet fermion that marries gauge neutral fermion operators, can naturally help provide a portal for entropy to return to the SM and to lift fermionic degrees of freedom in the Twin Sector. Together with spontaneous breaking of the $Z_2$ ${\rm SM \leftrightarrow {\rm Twin}}$ symmetry, there are new opportunities to confront the cosmological challenges of these models. Here, we attempt to develop such ideas. We shall show how one can lift many of the light fields by breaking $\ztwo$ with a $U(1)_Y$ scalar and its Twin partner. The introduction of Portalinos can lift the remaining degrees of freedom. We shall find that such models are highly constrained by precision SM measurements, motivating moderate extensions beyond this. We will discuss two, one with additional weak matter and another with additional colored matter. The weak model will involve simple two Higgs doublet models on top of $\ztwo$ breaking. The strong model will involve the presence of new leptoquarks and diquarks. We will discuss the implications for neutrino masses from radiative corrections and possible colored signals even within these models of neutral naturalness, some of which might appear at the LHC or future colliders.
Real-time thinning algorithms for 2D and 3D images using GPU processors

The skeletonization of binary images is a common task in many image processing and machine learning applications. Some of these applications require very fast image processing. We propose novel techniques for efficient 2D and 3D thinning of binary images using GPU processors. The algorithms use bit-encoded binary images to process multiple points simultaneously in each thread. The simpleness of a point is determined based on Boolean algebra using only bitwise logical operators. This avoids computationally expensive decoding and encoding steps and allows for additional parallelization. The 2D algorithm is evaluated using a data set of handwritten characters images. It required an average computation time of 3.53 ns for 32 $$\times$$ 32 pixels and 0.25 ms for 1024 $$\times$$ 1024 pixels. This is 52–18,380 times faster than a multi-threaded border-parallel algorithm. The 3D algorithm was evaluated based on clinical images of the human vasculature and required computation times of 0.27 ms for 128 $$\times$$ 128 $$\times$$ 128 voxels and 20.32 ms for 512 $$\times$$ 512 $$\times$$ 512 voxels, which is 32–46 times faster than the compared border-sequential algorithm using the same GPU processor. The proposed techniques enable efficient real-time 2D and 3D skeletonization of binary images, which could improve the performance of many existing machine learning applications.
Differential Effects of Anxiety Sensitivity on E-Cigarettes Processes: The Importance of E-Cigarette Quit Attempt History.

Background and objectives Electronic cigarettes (e-cigarettes) are recognized as a prevalent form of substance use among adults in the United States. The rise in e-cigarette use has motivated research to identify subgroups of the population that may be particularly vulnerable to e-cigarette use and its associated harm. Individuals with elevated psychological vulnerability are one such group more at risk for being a lifetime or current e-cigarette user. Yet, little is known about how factors of psychological vulnerability relate to perceptions of e-cigarette use within the context of e-cigarette quit attempts. The current study evaluated the differential relations of anxiety sensitivity (AS), a core affective vulnerability factor, on several relevant e-cigarette processes across those with and without a previous attempt to quit using e-cigarettes. Methods Our sample consisted of 547 current e-cigarette users (51% female, Mage = 35.38 years, SD = 10.1). Results Results indicated that AS significantly related to greater perceived risks, benefits, and positive outcome expectancies of e-cigarette use among current e-cigarette users who reported at least one attempt to quit e-cigarettes but was unrelated among those who had never attempted to quit. Discussion and conclusions Findings identify e-cigarette users who fail to quit as a potential vulnerable subgroup of users who experience more strongly held perceptions about e-cigarettes because of increased AS. Scientific significance This work provides initial evidence for a conceptual model in which levels of AS and e-cigarette processes are strengthened by and differ across e-cigarette quit attempt history. (Am J Addict 2019;28:390-397).
Integrity Threat Identification for Distributed IoT in Precision Agriculture

Internet-of-Things (IoT) paradigms have created, in addition to opportunities, a huge void in security. Although there are multiple works that explore security through device identification, cryptography and network security protocols, the question of can we trust the integrity of things to represent reality or precisely, can we trust the data and the metrics being sent by things, remains largely unanswered in distributed wireless scenarios. Given how nascent the domain is and the rapid pace at which IoT is being adopted, ensuring that the data from each of these devices is trustable is very challenging. Moreover, the problem becomes harder in wireless sensor network scenario, especially in harsh environments, due to the potential avenues for spoofing and physical attacks. To this end, this paper explores conditions or threat vectors under which a wireless network of devices may become unreliable in a fully distributed setting, and present an approach to identify potential integrity failures or threats. We present the effectiveness of our approach through a use–case analysis for precision agriculture applications. Through experimental and trace–based simulations, we show that threats can potentially be identified in real–time with 80% accuracy and at about 90% precision and recall.
DO I NEED A NEW HEART? EVALUATING THE NEED FOR HEART LUNG TRANSPLANTATION IN THE SETTING OF SEVERE PULMONARY HYPERTENSION

Those with severe pulmonary disease occasionally present with cardiac dysfunction in the setting of pulmonary hypertension (PH). This has important implications when approaching transplant evaluation as it might give the false impression that both heart and lung transplantation are needed. A 60
Energy-Aware Scheduling with Dynamic Voltage Scaling

Dynamic voltage scaling (DVS) [43] is widely acknowledged as one of the most effective processor energy saving techniques. The reason behind its capability to save energy is that linear reduction in the supply voltage leads to approximately linear slow down of performance while the power can be decreased quadratically. Many general as well as specific-purpose processors nowadays support DVS [60, 80, 81] with multiple available voltage levels.
Introduction: Exploring Agency, Ideology, and Semiotics of Language Across Communities

The introduction chapter opens with a framing discussion of the semiotic uses of language as a symbol in itself, rather than as a carrier of semantic meaning—and points out the importance that these uses can have in the contexts of metalinguistic communities where the focus may not be on the ability to speak or comprehend the language. The chapter then moves on to discuss the genesis of the volume and ethos shaping its creation, including a discussion of the importance of author positionality and an introduction to the model of metalinguistic community that frames the volume’s contributions. Each of the three themes that defines the sections of the book (Language Defining Belonging, Language Combating Erasure, Language Negotiating Hegemony) are discussed, followed by an analysis of some cross-cutting themes. The introduction concludes with a chapter-by-chapter summary, as well as guiding questions for the volume as a whole.
Studies of Elastic and Electronically Inelastic Electron-Molecule Collisions

Cross-sections for the scattering of low-energy electrons by molecules play an important role in the modeling of swarm and plasma etching systems, gas lasers, and planetary atmospheres. In contrast to the related atomic problem, the progress to date in both theoretical and experimental studies of electron-molecule scattering cross-sections has been limited [1]. On the theoretical side, this situation is primarily due to the additional complexities arising from the nonspherical potential fields of molecular targets. Most studies of electronic excitation of molecules by low-energy electrons have hence been carried out using low-order theories. These include plane-wave theories such as the Born Ochkur-Rudge approximations [2, 3], the impact-parameter method [4], and distorted-wave theories [5, 6]. Several studies of elastic scattering by molecules have also used local approximations to the nonlocal exchange potentials [7]. Although such theories and approximations can be computationally easy to apply, they do not contain enough of the collision physics to yield consistently reliable differential and integral cross sections, particularly at low and intermediate energies [8]. What is clearly needed are theoretical methods which can provide quantitatively reliable cross-sections for the elastic and inelastic scattering of low-energy electrons by molecules.
Cervical incompetence: current therapy.

Abstract 1. 1. Two techniques of external os surgical procedure for cervical incompetence occurring during pregnancy are presented, “bridge” tracheloplasty being the preferred one. 2. 2. A method of grading the severity of this disorder is suggested. 3. 3. Ten cases have been presented with 70 per cent success. Of these, 2 managed nonsurgically had 100 per cent success and 8 required operation with 63 per cent success. 4. 4. Management of the incompetent cervix is suggested. Operation is indicated by vaginal proof of cervical incompetence during pregnancy and by positive history of 2 or more fetal losses from the disorder. Appropriate surgical techniques are discussed.
Unsentimental Education: An Interview with Michael Haneke

Michael of challenges ethical Haneke's values and dysfunctions cinema and teachings is best of European , known a lack for society of communication thematizing . The absence the challenges and dysfunctions of European society . The absence of ethical values teachings , a la k of communication and passively endured interpersonal alienation are often dramatized in conflicts between parents and their children. In fact, several of Haneke' s films could be described as perversions of the Bildungsroman, the bourgeois literary genre that depicts a young protagonist's painful but instructive path to maturation. If the genre is not always immediately recognizable in Haneke' s films , it is because they may use only certain elements from it that they turn inside out: a focus on psychology is substituted by an exterior portrait of the consequences and effects of characters3 decisions and actions ; inference takes the place of explicit description; and, most importantly, intellectual and moral development, rather than being celebrated, is identified through negative, even diabolical, examples. Haneke' s new film, The White Ribbon, tells the story of how a small village comes under the spell of a series of violent incidents. The local doctor has a riding accident when his horse is felled by a wire clearly installed for this purpose; a woman crashes through the rotten wood floor of a barn and dies; the son of the Baron is found tied up and beaten ; the barn of the Baron's estate burns down; the handicapped child of the local midwife is found stabbed in the eyes. Two explicit scenes one depicting the sons of the estate's foreman throwing the Baron's son into the pond despite the fact that he can't swim, the other showing the pastor's daughter seizing the pet bird that her father later finds " crucified " on his desk suggest that at least some of the incidents may have been planned and perpetrated by children of the village. For the most part, the film depicts the children as listeners, bystanders, eavesdroppers, and receivers of commands. They are interviewed by the police and ordered about by their parents ; who punish them for their reticence and force them to wear around their arms a white ribbon as a symbol of the moral virtue they are deemed lacking. But one can't help but sense that the children may have formed some sort of secret society. They seem to study their parents closely, realizing that their parents do not live by the morals they preach. We don't learn exactly how much they find out about their parents' secret infringements, but if it is a fraction of what the film reveals to us viewers namely acts of violence, adultery, and incest it is not hard to see how the chil-
WindPACT Turbine Rotor Design, Specific Rating Study; Period of Performance: June 29, 2000--March 1, 2003

In 2000, the National Renewable Energy Laboratory (NREL) launched the Wind Partnerships for Advanced Component Technologies (WindPACT) program to examine ways in which the cost of wind energy could be reduced a further 30%. One element of the WindPACT program has been a series of design studies aimed at each of the major subsystems of the wind turbine to study the effect of scale and of alternative design approaches. The WindPACT Turbine Rotor Design Study was carried out by Global Energy Concepts, LLC, (GEC) on behalf of NREL, and the final report was delivered in June 2002. The study examined what configuration and design changes in the rotor would reduce the overall cost of energy. The objectives of this report are to use the 1.5-MW baseline configuration from the earlier WindPACT Rotor Design Study to examine the effect of different power ratings and to identify an optimum specific rating; to examine the effect of different maximum tip speeds on overall cost of energy (COE); to examine the role of different wind regimes on the optimum specific rating; and to examine how the optimum specific rating may be affected by introducing more advanced blade designs.