Factors Related to Higher Neurobiological Capital Across the Lifespan: Mayo Clinic Study of Aging (S34.002)

Objective: Our goal was to examine risk factors and cognitive outcomes for imaging measures related to cognitive aging across the lifespan. Background: Three anatomically distinct regions play an important role in cognitive aging: Entorhinal cortex is susceptible to aging/pathology, parietal lobe is an integrative functional hub, and frontal lobe may reflect early cerebrovascular disease. Here, we used imaging measures in these regions to capture associations with protective and risk factors for each subject – Entorhinal cortex (ERC) thickness, superior parietal lobe (SUP) thickness, and DTI-based genu corpus-callosum fractional anisotropy (GCC). Design/Methods: We identified 796 (30–49 years, n=127; 50–64 years, n=558; ≥65 years, n=111) population-based individuals (30.8–93.0 years, 48.2% female) with imaging from the Mayo Clinic Study of Aging. We computed each of the imaging measures and created a composite score from a percentile-based ranking system for individual measures. We investigated protective and risk factors and cognitive outcomes associated with individual imaging measures and the imaging composite score using t-test and chi-square. Significant relationships at p Results: In 30–49 year olds, higher GCC was related to greater total brain volume and higher ERC thickness was related to better memory performance. In 50–64 year olds, higher imaging measures were related to lower current metabolic/vascular risk (composite and ERC thickness), greater total brain volume (composite and GCC), higher global cognition (composite and SUP thickness), lower history of smoking/alcohol problems (composite and SUP thickness), and higher prevalence of marriage (ERC and SUP thickness). Elderly (≥65 years old) with high imaging measures had higher prevalence of marriage (all measures) and lower history of alcohol problems (composite) compared to young adults with high imaging measures. Conclusions: Each of the imaging measures captures a unique aspect of cognitive aging. Imaging biomarkers associated with distinct risk and protective factors will be useful for building a richer conceptual model of cognitive aging. Disclosure: Dr. Neth has nothing to disclose. Dr. Graff-Radford has nothing to disclose. Dr. Przybelski has nothing to disclose. Dr. Schwarz has nothing to disclose. Dr. Reid has nothing to disclose. Dr. Mielke has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Lysosomal Therapeutics, Inc. Dr. Mielke has received research support from Biogen, Roche, and Lundbeck. Dr. Petersen has nothing to disclose. Dr. Jack has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lily. Dr. Knopman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Washington University for the DIAN study. Dr. Knopman has received research support from Biogen Pharmaceuticals and Lilly Pharmaceuticals. Dr. Vemuri has nothing to disclose.