Augmented efficacy of exogenous extracellular vesicles targeted to injured kidneys.

All data relevant to this work are included in this paper and Supplementary Information. Choi, H. & Lee, D. S. Illuminating the physiology of extracellular vesicles. Stem Cell Res. Ther. 7, 55 (2016). Article Google Scholar Zou, X. et al. Targeting murine mesenchymal stem cells to kidney injury molecule-1 improves their therapeutic efficacy in chronic ischemic kidney injury. Stem Cells Transl. Med. 7, 394–403 (2018). CAS Article Google Scholar Eirin, A. et al. Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation. Kidney Int. 92, 114–124 (2017). CAS Article Google Scholar Dimke, H. et al. Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney. J. Am. Soc. Nephrol. 26, 1027–1038 (2015). CAS Article Google Scholar He, F. F. et al. Angiopoietin-Tie signaling in kidney diseases: an updated review. FEBS Lett. 593, 2706–2715 (2019). CAS Article Google Scholar Download references This work was partly supported by NIH Grants Numbers DK122734, DK102325, and DK120292. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA Xiao-Jun Chen, Kai Jiang, Christopher M. Ferguson, Hui Tang, Xiangyang Zhu & Lilach O. Lerman Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Xiao-Jun Chen Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA Amir Lerman & Lilach O. Lerman You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar X.-J.C., X.Z., and L.O.L. conceived and designed the study. X.-J.C. and H.T. analyzed and interpreted experiments. K.J. and C.M.F. performed and interpreted MRI experiments. X.Z., A.L., and L.O.L. supervised, interpreted, and provided intellectual input. X.-J.C. and L.O.L. wrote the manuscript with input from all coauthors. L.O.L. oversaw experimental design, data analyses, and manuscript preparation. Correspondence to Lilach O. Lerman. L.O.L. receives funding from Novo Nordisk and advises Weijian Technologies and AstraZeneca. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and Permissions Chen, X., Jiang, K., Ferguson, C.M. et al. Augmented efficacy of exogenous extracellular vesicles targeted to injured kidneys. Sig Transduct Target Ther 5, 199 (2020). https://doi.org/10.1038/s41392-020-00304-6 Download citation Received: 28 January 2020 Revised: 03 August 2020 Accepted: 20 August 2020 Published: 14 September 2020 DOI: https://doi.org/10.1038/s41392-020-00304-6