cssi/SciSciGPT-SciSciNet huggingface dataset:
Training Interdisciplinary Student Health Teams in a Gerontological Setting.

This is a report of the genesis and evolution of an interdisciplinary health care experience for student teams in a gerontological setting. Six health‐related disciplines were represented in the teams. Teams functioned in an extended care facility. An attempt was made to have students involved in tasks compatible with their level of competence. The student teams faced many of the same problems encountered by other interdisciplinary health care teams, including role definition, role negotiation, decision making, and conflict resolution. At the same time, the faculty found systematic interventions necessary to ensure an appropriate balance between task and team maintenance.
Induction Of Anti-Myeloma Cellular and Humoral Immunity By Pre-Targeting Clonogenic Myeloma Cells Prior To Stem Cell Transplant With T Cells Armed With Anti-CD3 x Anti-CD20 Bispecific Antibody Leads To Transfer Of Cellular and Humoral Anti-Myeloma Immunity

![Graphic][1] A phase Ib trial was conducted in standard and high risk multiple myeloma (MM) patients to determine whether infusions of anti-CD3 x anti-CD20 bispecific antibody (CD20Bi) armed activated T cells (aATC) prior to autologous stem cell transplant (ASCT) were safe and would induce anti-myeloma (anti-MM) immunity that could be detected after ASCT. We hypothesized that targeting CD20+/CD138- myeloma clonogenic cells with aATC would release “MM antigens” including anti-Sry-HMG-box 2 (SOX-2). Engagement of target cells by aATC also induces release of Th1 cytokines by aATC creating an environment conducive for in situ immunization against MM antigens. Twelve patients received two infusions of 1010 one week apart and within 4 weeks prior to ASCT. Four patients received a 10 x 109 aATC booster infusion between 6 and 18 months after ASCT. There were significant increases in the fraction of patients who developed IFN-g EliSpots directed at CD20+ Daudi lymphoma cells (p<0.06), CD20 negative RPMI 8226 multiple myeloma cells (p<0.02), and K562 natural killer cell targets (p<0.01) from 6 to 12 months after ASCT. Specific cytotoxicity directed at Daudi (p<0.03), K562 (p<0.009), and RPMI 8226 (p<0.02) targets increased significantly after aATC infusions and post ASCT compared to pre infusion baseline cytotoxicity. SOX-2 IgG antibody levels increased above baseline after aATC infusions (p<0.002) and post ASCT (p<0.02) (Fig. 1A). There was no significant difference observed between pre and 1 month post ASCT in anti-SOX-2 levels or between pre and 3 month post ASCT serum samples from control ASCT patients who did not receive IT (Fig. 1B). In order to determine whether there was an association between the level of anti-SOX-2 antibodies and clinical outcome, anti-SOX-2 antibody levels were plotted in patients who progressed and those who did not progress. The box plots show the clear separation between two groups. The median anti-SOX-2 antibody levels at 3 months after ASCT in patients who relapsed was 19.7 ng/ml (25-75%, 8.6 - 40.3) and in patients who remained in remission was 48.1 ng/ml (37.5 - 73.3), these data suggest that anti-SOX-2 levels may predict clinical outcomes (Fig. 1C). There were no dose-limiting toxicities. In summary, aATC infusions pre ASCT induced anti-myeloma IFN-g EliSpot and anti-SOX-2 IgG responses that could be detected at 6-12 months after ASCT and these responses were boosted in 4 of 4 patients after ASCT. Data suggest that infusions of targeted T cells given prior to ASCT could induce cellular and humoral anti-myeloma immunity that could be transferred, detected, and boosted after ASCT. These results have implications for the design of immunotherapy in combination with ASCT. ![Figure][2] Disclosures: Lum: Transtarget Inc: Equity Ownership, In situ Immunization Patent, In situ Immunization Patent Patents & Royalties. [1]: /embed/inline-graphic-2.gif [2]: pending:yes
Using a Genome-Scale Model and Genomic Library to Discover the Functions of Metabolic Genes

Vibrio fischeri is a bioluminescent marine bacterium that forms a symbiotic relationship in the light-emitting organ of the Hawaiian bobtail squid, Euprymna scolopes. To better understand the metabolism of V. fischeri, we constructed a V. fischeri genome-scale metabolic model ­and developed a novel approach for finding functions of metabolic genes using genomic libraries. Our V. fischeri model captures most V. fischeri biochemical reactions and their associated genes based on the current genome annotation. While the model was highly accurate at predicting carbon sources (86.2% accuracy) and gene essentiality (83.4% accuracy), the incorrect predictions by the model indicate that there are metabolic functions missing from our model and the current genome annotation.We developed a new integrated computational and experimental approach to find the genes responsible for these missing metabolic functions. This approach uses computational models to design selection strategies for these missing reactions. These selection strategies specify a medium condition and a recipient strain whose growth in this media is dependent on the metabolic function being sought. Genomic libraries (in this case derived from V. fischeri) are then transformed into the recipient strain and growth selections are used to identify the genes responsible for the missing metabolic function. This approach identified 5 genes responsible for 4 missing metabolic functions (including enzymes and transporters) in V. fischeri. Additional experiments involving knockout mutant complementation, mutant growth phenotyping, and enzyme assays further supported that the genes identified from the genomic library are responsible for these metabolic activities in V. fischeri. This integrated computational and experimental approach can be generally applied to a broad range of microbes to improve their genome annotations and our understanding of their metabolic capabilities.
Chaotic Advection and Its Application to Extruding Micro- and Nanostructured Plastic Materials

Publisher Summary Chaotic advection-based processing of plastics is a new plastics processing technology that offers opportunities to enhance physical properties, impart functionalities, or create decorative patterns in extrusions. It can be used with existing polymer resins and is well suited to melt processing of shear sensitive materials. Droplet dispersions or solid particle mixtures can also be produced. Both miscible and immiscible polymer combinations can be used although structural outcomes differ. Structured plastics can be extruded that can contain, for example, thousands of layers, spongelike assemblies, interconnected layers, percolating networks, ribbons, abundant submicron fibers, or oriented particles. Chaotic advection is a subject of fluid mechanics that denotes the chaotic movements of passive particles in response to even simple flowfields. Because of chaotic advection, it is now understood that complex particle motions in fluids do not require complex flow fields. Even where discrete particles do not exist in a polymer melt, this understanding is useful because small melt domains move in a similar fashion. Simple flow fields allow controllable formation in melts of structures that can have both fine-scale features while also being physically expansive. For example, two polymer components can be arranged into thousands of thin alternating layers or into a blend consisting of long, submicron fibers.
Pulmonary arterial hypertension: screening challenges in systemic sclerosis and future directions.

Screening for PAH is significant in scleroderma as it may lead to early diagnosis and initiation of therapy http://ow.ly/TR6230aqRgq
En La Lucha: The Struggles and Triumphs of Latino/a Preservice Teachers

Background/ContextSeveral studies have argued that the academic struggles of Latino/a students are connected, at least in part, to the dearth of Latino/a teachers and other school personnel who may...
Governance and Women's Economic and Political Participation: Power Inequalities, Formal Constraints and Norms

Have institutional reforms been successful in reducing persistent gender gaps in economic and political participation? This paper argues that, at the roots of current gender inequalities, there are...
Secession on Trial : The Treason Prosecution of Jefferson Davis

This book focuses on the post-Civil War treason prosecution of Confederate President Jefferson Davis, which was seen as a test case on the major question that animated the Civil War: the constitutionality of secession. The case never went to trial because it threatened to undercut the meaning and significance of Union victory. Cynthia Nicoletti describes the interactions of the lawyers who worked on both sides of the Davis case - who saw its potential to disrupt the verdict of the battlefield against secession. In the aftermath of the Civil War, Americans engaged in a wide-ranging debate over the legitimacy and effectiveness of war as a method of legal adjudication. Instead of risking the 'wrong' outcome in the highly volatile Davis case, the Supreme Court took the opportunity to pronounce secession unconstitutional in Texas v. White (1869).
Multigroup Analysis of the General Theory of Deviant Behavior

Several good theoretical rationales could be offered that suggest moderating effects of race/ethnicity on the parameter estimates in the model. This is the case for both the measurement and structural equation portions of the previously estimated model. For example, Matsueda and Heimer (1987) suggest that when considering control theory it is possible that neighborhood delinquency will produce more delinquency among African-Americans by inhibiting strong formation of conventional attachments and beliefs. To this extent, informal social control would not provide the same inhibiting effects for African-Americans as for white-Anglos. Others have also argued that white-Anglos are more vulnerable to informal sanctions and that African-Americans would be more vulnerable to formal sanctions when considering theories of social control (Tittle, 1980). Similarly, Matsueda and Heimer (1987) have argued that conditioning effects of race may be apparent in considering differential association theories such that determinants of deviant definitions may vary by race. But they maintain this theory would predict that the determinant of deviant behavior by those definitions will not vary by race. Thus, they argue for both conditioning effects by race as well as expected invariance by race. Presumably the determinants of deviant definitions that vary by race are the social structural parameters that determine the experience of racial minorities within the social structure, and within certain social institutions including the family and school, but that once these factors have defined the normative and contranormative environmental definitions, the extent of the definitions that are favorable, in terms of motivating factors, will influence the onset of delinquency equally in both groups.
Summary and concluding comments: neural cells as secretory units.

It is difficult to summarize adequately the discussions of the past two days. This workshop has been necessarily restricted in scope, since the releasing hormones form only one small component of the reproductive system, the flag that brings this Study Section together three times a year. Thus, there is much of the reproductive system which has not been discussed; at the same time, however, the releasing hormones have been approached quite broadly. In fact, Roger Guillemin began by considering releasing-hormone producing cells as only one example of a broader category of cells derived from neural ectoderm, but then the discussions proceeded to range from molecular anatomy, even its evolution, to possible modifications of human behavior.
Computer Experiments with System Reliability Methods: A Critical Study

ABSTRACT The main purpose of this paper is to discuss probabilistic methods which are of practical interest for the reliability evaluation of engineering systems and to present computer experiments with some of these methods. The results are useful for calculating the reliability of different types of systems with uncertain interdependent properties and acted on by random interdependent loads, including both structures for supporting overhead electric transmission lines and underground distribution systems.
Service science: on reflection

In this chapter, we reflect on the historical challenges and the future prospects for the scientific study of service phenomena. The growing dominance of the “service” component of national economies and corporate revenues has spurred expanded interest in service systems and service innovation. Service innovations based on global-scale information technology platforms are further fuelling interest in the scientific study of digitally connected service via cloud computing and smart phones. Practitioners and employers should be aware of and take advantage of the emergence of service science, as more and more universities around the world expand and deepen their service science-related curricula and research.
Is vaginal misoprostol more effective than oral misoprostol for cervical ripening in obese women

Objective: To determine if vaginal misoprostol is more effective than oral misoprostol for cervical ripening in obese women.Study design: A retrospective cohort study of obese women undergoing indu...
Maintaining an Effective Lab Notebook and Data Integrity

Efficient, organized, and detailed data maintenance are the cornerstones of a successful laboratory. Furthermore, institutional and federal requirements mandate proper maintenance, documentation, and dissemination of experimental data in a way that is rigorous and reproducible. The complexity of data generated in the modern laboratory setting presents a significant challenge to these principles of proper record keeping and data integrity. This chapter will focus on the elements of the scientific method, data maintenance, and paper and electronic record keeping that can be used to facilitate successful laboratory operations for the surgeon-scientist conducting basic research. In addition, there is recent increased emphasis on measures to ensure experimental rigor and reproducibility supported by the scientific community and National Institutes of Health. This chapter will introduce the surgeon-scientist to the critical aspects of these requirements to ensure compliance with grant submission guidelines and common author instructions for manuscript submission.
The search for meaning in preclinical Alzheimer disease clinical trials

Alzheimer disease (AD) is an age-associated clinical condition marked by neuropathologic β-amyloid plaque and tau accumulation, deterioration in episodic memory and other cognitive abilities, and decline in functional living abilities. According to the newly released 2019 Alzheimer's Association Facts and Figures, 1 AD now affects 5.8 million people in the United States, a new case of AD occurs every 65 seconds, and 1 in 3 older adults will die of AD or another form of dementia. Blacks and Hispanics are at a disproportionately higher risk for AD, and the cost due to this disease in the United States alone is estimated to be over $290 billion dollars. The profound individual and social burden of AD points decidedly to the need for better characterization of the preclinical phase to develop, monitor, and test the efficacy of clinical interventions designed to ameliorate this growing public health crisis.
Association Between Prior Insurance and Health Service Utilization Among the Long-Term Uninsured in South Carolina

Abstract Purpose: Strong evidence supports the relationship between health coverage and improved health status. Little is known about the lasting impact of prior health insurance on the prior insur...
Method for Approximating Field-Line Curves Using Ionospheric Observations of Energy-Variable Electron Beams Launched From Satellites

Using electron beam accelerators attached to satellites in Earth orbit, it may be possible to measure arc length and curvature of field-lines in the inner magnetosphere if the accelerator is designed with the capability to vary the beam energy. These measurements would be very useful in constraining the magnetic field of the inner magnetosphere. For the purpose of properly applying these constraints, a new three step data assimilation modeling approach is discussed. The first step in the procedure would be to use prior information to obtain an initial forecast of the inner magnetosphere. Then, a general curve would be defined that satisfies the observed geometric attributes measured by the experiments, and the prior forecast would then be used to optimize the curve with respect to the allowed degrees of freedom. Finally, this approximation of the field-line would be used to improve the initial forecast of the inner magnetosphere, resulting in a description of the system that is optimally consistent with both the prior information and the measured curvature and arc length. This article details the method by which a family of possible approximations of the field-line may be defined, which is central to the three step approach.
When savannas recover from overgrazing, ecohydrological connectivity collapses

Grasslands and savannas across the globe have undergone a dramatic transition over the past century. Historical overgrazing has set in motion a cascade of events ranging from desertification in arid climates to woody plant encroachment (WPE) in semiarid and subhumid climates. In recent decades, grazing pressure on many of these landscapes has declined significantly, and where rainfall is sufficient (as in most semiarid and subhumid settings), herbaceous vegetation in intercanopy areas will recover. An important question is, how has this transition altered ecohydrological connectivity (overland flow and runoff–runon dynamics)? A woody-plant-encroached, subhumid savanna site in South Texas with a history of heavy grazing (but ungrazed since 1981) was used as a model landscape to address this question. Overland flow, soil moisture, and field saturated hydraulic conductivity (K fs) were measured along a catena extending from the upland savanna-parkland areas to the downslope, more densely wooded areas. For comparison, K fs and infiltrability were also measured at a moderately grazed upland site 14 km east of our study site, selected as a surrogate for past conditions at our site. In contrast to the prevailing hypothesis that the downslope areas ('drainage-woodlands') at our study site have continued to be supported by runoff generated from the upland areas, our measurements yielded no evidence for the redistribution of water from the uplands to the drainage areas under the current ungrazed conditions. Further, K fs at the ungrazed study site was two orders of magnitude higher than that at the grazed site and infiltrability was twice as high at the ungrazed site than the grazed site. These findings, coupled with historical information from the site, strongly suggest that historical overgrazing amplified the runoff–runon process, resulting in significant subsidies of water from the uplands to the drainage areas. Then, with the relaxation of grazing pressure and subsequent landscape recovery, redistribution of water via surface runoff was relatively rare. We believe that our results are generalizable for savannas that have recovered from overgrazing. When these savannas are heavily grazed, ecohydrological connectivity is greatly increased; but if grazing pressure relaxes, ecohydrological connectivity will collapse. These changes in ecohydrological connectivity have important, but not always well understood, ecological consequences.
Management of synchronous lateral pelvic nodal metastasis in rectal cancer in the era of neoadjuvant chemoradiation: A systemic review.

Management of synchronous lateral pelvic nodal metastasis in rectal cancer in the era of neoadjuvant chemoradiation: A systemic review
A fractional analysis of Noyes–Field model for the nonlinear Belousov–Zhabotinsky reaction

Nonlinear phenomena play an essential role in various field of natural sciences and engineering. In particular, the nonlinear chemical reactions are observed in various domains, as, for instance, in biological and chemical physics. For this reason, it is important to investigate the solution to this nonlinear phenomenon. This article investigates numerical solutions to a nonlinear oscillatory system called the Belousov–Zhabotinsky with Caputo fractional-time derivative. The simplified Noyes–Field fractional model reads $$\begin{aligned} {\mathcal {D}}_t^{\mu }p= & {} \xi _1p_{xx}+\beta \delta {w}+p-p^2-\delta {pw},\quad 0<\mu \le 1,\\ {\mathcal {D}}_t^{\mu }w= & {} \xi _2w_{xx}+ \gamma {w}-\lambda {pw}, \end{aligned}$$ where $$\xi _1$$ and $$\xi _2$$ are the diffusing constants for the concentration p and w respectively, $$\gamma $$ and $$\beta $$ are given constants, $$\lambda \ne 1$$ and $$\delta $$ are positive parameters. The two iterative techniques used in this work are the fractional reduced differential transform method and q-homotopy analysis transform method. The outcomes using these two methods reveal an efficient numerical solution with high accuracy and minimal computations. Furthermore, to better understand the effect of the fractional order, we present the solution profiles which demonstrate the behavior of the obtained results.
Supraorbital Craniotomy for Sellar Solitary Fibrous Tumor: Operative Technique and Literature Review.

Objective Solitary fibrous tumors (SFT) are rare, locally aggressive, mesenchymal neoplasms that pose both diagnostic and operative challenges. In this review of the literature, data were collected from all previously described sellar and suprasellar SFTs to date, with special attention paid to presenting symptoms, surgical technique performed, recurrence status, and adjuvant radiotherapy or chemotherapy, among others. Methods A review of prior sellar and suprasellar SFTs was performed. Eleven cases of SFTs in the sellar and suprasellar regions were identified. We considered age and sex, along with case-specific information, such as presenting symptoms, surgical approach taken, number of resections, recurrence information, and adjuvant therapy. Results All cases including ours presented with visual deficits, ranging from blurry vision to complete bilateral visual loss. Endocrine hormonal abnormalities occurred in nearly all patients (90%.) Craniotomy was performed more often than endonasal transsphenoidal resection of tumors, 42% versus 33%, respectively. Conclusions SFTs are slow-growing fibroblastic mesenchymal neoplasms that comprise
Power politics: Armed non-state actors and the capture of public electricity in post-invasion Baghdad:

Scholars observe that armed non-state actors (NSAs) often provide social services to reinforce their popular support and legitimacy as guarantors of local order. On the other hand, NSAs usually fac...
Increasing Reoperations and Failures With Increasing BMI in Patients Undergoing 2-Stage Exchange for Infected Total Hip Arthroplasty.

Abstract Background While morbid obesity is associated with increased infection after total hip arthroplasty, little is known on the outcomes after 2-stage reimplantation for prosthetic joint infection (PJI) in this population. The purpose of this study is to evaluate the impact of morbid obesity (body mass index>40 kg/m2) on reinfection, postoperative complications, readmissions, and reoperations. Methods We conducted a retrospective review of 107 patients undergoing first time 2-stage reimplantation for PJI from 2013 to 2019. 18 patients (50% women) with body mass index>40 kg/m2 were identified. To minimize confounders, three propensity score matched cohorts were created, yielding 16 nonobese ( 40 kg/m2) patients. Outcomes were compared using chi-square or Fisher’s exact tests. All patients had minimum 12-month follow-up, with mean follow-up of 36.3, 30.1, and 40.0 months in the nonobese, obese, and morbidly obese cohorts, respectively. Results Compared with nonobese patients, morbidly obese patients had a higher rate of reinfection (0% vs 33%, P = .020 and higher likelihood of length of stay>4 days (19% vs 61%, P = .012). In addition, compared with nonobese and obese patients, morbidly obese patients had higher rate of return to the operating room for any reason (13% vs 19% vs 50%, respectively, P = .020). No differences between cohorts were found regarding complications, death, or revision surgery. Conclusion Morbidly obese patients have significantly increased risk of reinfection and reoperation after 2-stage reimplantation for PJI when compared with obese and nonobese patients. These data can be used to counsel morbidly obese patients contemplating total hip arthroplasty and supports the notion of deferring arthroplasty in this population pending optimization.
Essential Health and Nutrition Service Provision during the COVID-19 Pandemic: Lessons from Select Ethiopian Woredas

The world has faced a public health emergency due to the emergence of the COVID-19 pandemic A cross-sectional study with mixed methods was conducted to review the status of maternal and child health care and nutrition service delivery during the early months of the pandemic in woredas (districts) targeted by the Growth through Nutrition Activity, a multi-sectoral nutrition project in Ethiopia Comparison with the previous year showed some decline in key maternal and child health and nutrition services, with more pronounced effects during the early months of March and April before coordinated effort and standard guidance were well established A recovery of most services was likely due in no small part to a range of mitigation interventions implemented by respective health workers and institutions, supervising government organizations, and through support from non-governmental organizations
Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy

The cellular response to hypoxia is a key biological process that facilitates adaptation of cells to oxygen deprivation (hypoxia). This process is critical for cancer cells to adapt to the hypoxic tumor microenvironment resulting from rapid tumor growth. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor and a master regulator of the cellular response to hypoxia. The activity of HIF-1 is dictated primarily by its alpha subunit (HIF-1α), whose level and/or activity are largely regulated by an oxygen-dependent and ubiquitin/proteasome-mediated process. Prolyl hydroxylases (PHDs) and the E3 ubiquitin ligase Von Hippel-Lindau factor (VHL) catalyze hydroxylation and subsequent ubiquitin-dependent degradation of HIF-1α by the proteasome. Seven in Absentia Homolog 2 (SIAH2), a RING finger-containing E3 ubiquitin ligase, stabilizes HIF-1α by targeting PHDs for ubiquitin-mediated degradation by the proteasome. This SIAH2-HIF-1 signaling axis is important for maintaining the level of HIF-1α under both normoxic and hypoxic conditions. A number of protein kinases have been shown to phosphorylate SIAH2, thereby regulating its stability, activity, or substrate binding. In this review, we will discuss the regulation of the SIAH2-HIF-1 axis via phosphorylation of SIAH2 by these kinases and the potential implication of this regulation in cancer biology and cancer therapy.
How Novelty and Narratives Drive the Stock Market: Black Swans, Animal Spirits and Scapegoats

'Animal spirits' is a term that describes the instincts and emotions driving human behaviour in economic settings. In recent years, this concept has been discussed in relation to the emerging field of narrative economics. When unscheduled events hit the stock market, from corporate scandals and technological breakthroughs to recessions and pandemics, relationships driving returns change in unforeseeable ways. To deal with uncertainty, investors engage in narratives which simplify the complexity of real-time, non-routine change. This book assesses the novelty-narrative hypothesis for the U.S. stock market by conducting a comprehensive investigation of unscheduled events using big data textual analysis of financial news. This important contribution to the field of narrative economics finds that major macro events and associated narratives spill over into the churning stream of corporate novelty and sub-narratives, spawning different forms of unforeseeable stock market instability.
Persistent Spin Helix-Based Spin Field Effect Transistor

Spintronic device is promising due to their potential merits of low power consumption and fast operation. In this work, we present the effect of persistent spin helix, barrier resistance, spin polarization and channel resistance on the magnetoresistance of spin field effect transistor (FET) when the channel material carries strong spin-orbit coupling (SOC) and persistent spin helix (PSH). Our device shows promising spintronic performance with current device technologies.
CT Osteoabsorptiometry Assessment of Subchondral Bone Density Predicts Intervertebral Implant Subsidence in a Human ACDF Cadaver Model

Study Design:Cadaveric biomechanics study.Objective:Subchondral bone mineral density (sBMD) reflects the long-term mineralization and distribution of stress on joints. The use of 3-dimensional (3-D...
Characterization of humoral response to COVID mRNA vaccines in multiple sclerosis patients on disease modifying therapies.

Little is known about COVID-19 mRNA vaccine humoral immune responses in patients with central nervous system autoimmune demyelinating diseases, multiple sclerosis (MS) and neuromyelitis optica (NMO), who are on B-cell depleting therapies (BCDT) and other disease modifying therapies (DMTs). We conducted a single center prospective study to identify the clinical and immunological features associated with vaccine-induced antibody response in 53 participants before and after COVID-19 mRNA vaccination. This is the first report on the anti-spike RBD and anti-nucleocapsid antibody response, along with pre- and post-vaccine absolute lymphocyte counts (ALC) and flow cytometry analysis of CD19 and CD20 lymphocytes in patients with MS and NMO. We tested the hypothesis that patients on BCDT may have impaired COVID-19 vaccine humoral responses. Among patients on BCDT, 36.4% demonstrated a positive antibody response to spike RBD, in comparison to 100% in all other groups such as healthy controls, untreated MS, and patients on non-B cell depleting DMTs (p < 0.0001). Immunological data revealed lower baseline (pre-vaccination) levels of IgM in patients on BCDT (p = 0.003). Low CD19 and CD20 counts and a shorter interval from the last B cell depleting therapy infusion to the first vaccine dose were associated with a negative spike RBD antibody response (non-seroconverter) in patients on BCDT. Age, body mass index (BMI) and total treatment duration did not differ between seroconverters and non-seroconverters.
Crisis Counseling, intervention, and Prevention in the Schools

1. Conceptualizations and Principles of Crisis Counseling, Intervention, and Prevention, Jonathan Sandoval 2. Preparing for the School Crises Response, Stephen E. Brock 3. Considering Culture in Crisis Work, Jonathan Sandoval 4. School Entry, School Failure, and the Discovery of Learning Disabilities, Collette L. Ingraham 5. Divorce: Crisis Intervention and Prevention with Children of Divorce and Remarriage, Andrew M. Lamden & Jonathan Sandoval 6. Bullying: Students hurting students, Juliana Raskauskas 7. Child Maltreatment, Linda Webster 8. Helping Children Cope with Grief, Aubrey Uresti 9. Illness: A Crisis for Children, Dianne Castillano & Amy N. Scott 10. Disabled, Incarcerated or Deployed Parents, Mari Griffiths Irvin, Melissa Keane & Jonathan Sandoval 11. The Stress of Moving, Jonathan Sandoval12. Acts of Violence, Jonathan Sandoval, Stephen E. Brock & Katie Knifton 13. Preparing for and Responding to Disaster, Stephen E. Brock, Quinn Ballard & Christina Saad 14. Suicide, Oanh Tran, Alexis S. Pham & John M. Davis 15. Lesbian, Gay, Bisexual, Transgender, and Questioning (LGBTQ) Youth, Suzy R. Thomas 16. Adolescent Pregnancy and Parenthood, Katherine Hadley Cornell 17. Conflict and Crisis within the Family System, Suzy R. Thomas & Jeff Cook 18. Rape and sexual assault, Virginia Schiefelbein & Jonathan Sandoval 19. Non-suicidal Self Injury, David N. Miller
Violence and Temporal Subjectivity

SUMMARY Perceptions of temporal malleability and subjectivity are experienced by many perpetrators, victims, and witnesses of violence. Are perceptions of the slowing down, speeding up, or heightened awareness of time, which accompany violent moments, indicative of broader cultural and humanistic phenomena? In this article, I explore accounts of temporal perceptions surrounding violent encounters as a methodologically useful field of intersection between theories concerning the cultural construction of reality, the anthropology of time, simulation, and an emergent holographic physics. If, as a growing number of physicists assert, the universe can be described as a hologram where “time” is illusory and simultaneous, violent events that are perceived as temporally ambiguous offer sites of particular interest for the humanistic examination of these physical models. In other words, the temporal subjectivity often experienced by those who encounter violence can be interpreted as directly perceivable holographic encounters. The perpetrators, victims, and witnesses of such encounters can be viewed not only as interpreters of particular cultural temporal systems but also actively manipulating space–time and socially constructed reality. Interpreting violence through the experience of human agents could lead to greater insight into not only the symbolic meaning generated by acts of violence but also its hyperreal, desensitizing, and dissociative effects. Furthermore, the amplification of these effects by mass media and modern state ideologues becomes more penetrable under such an interpretive model. I draw from ethnographic research with police and “security” personnel in Thailand, Vietnam, and the United States, as well as from media and performance analysis.
Heart failure with preserved ejection fraction: defining the function of ROS and NO

The understanding of complex molecular mechanisms underlying heart failure (HF) is constantly under revision. Recent research has paid much attention to understanding the growing number of patients that exhibit HF symptoms yet have an ejection fraction similar to a normal phenotype. Termed heart failure with preserved ejection fraction (HFpEF), this novel hypothesis traces its roots to a proinflammatory state initiated in part by the existence of comorbidities that create a favorable environment for the production of reactive oxygen species (ROS). Triggering a cascade that involves reduced nitric oxide (NO) availability, elevated ROS levels in the coronary endothelium eventually contribute to hypertrophy and increased resting tension in cardiomyocytes. Improved understanding of the molecular pathways associated with HFpEF has led to studies that concentrate on reducing ROS production in the heart, boosting NO availability, and increasing exercise capacity for HFpEF patients. This review will explore the latest research into the role of ROS and NO in the progression of HFpEF, as well as discuss the encouraging results of numerous therapeutic studies.
Time-Cost Performance Effect of Change Orders from Accelerated Contract Provisions

AbstractAccelerated contract provisions (ACPs) such as cost-plus-time (A+B) and incentives/disincentives (I/D) are increasingly common, yet very little is known about their pure time-cost performance effects on change orders. To fill this large knowledge gap, a two-stage research methodology drawing on 1,372 highway improvement projects completed in California was adopted for this study. The Stage I study investigated the marginal change-order impacts of two ACPs, pure A+B and I/D combined with A+B. How ACP change orders affect projects’ time-cost performance was numerically modeled and successfully validated over the Stage II study. The results clearly showed that both ACPs led to more schedule-change and cost-change orders than conventionally contracted projects, whereas I/D combined with A+B performed significantly better than pure A+B in terms of the magnitude of schedule-change orders. This conveys an important recommendation to state transportation agencies (STAs) that A+B be used with an I/D provis...
A new genetic algorithm for Resource Constrained Project Scheduling

The Project Scheduling Problem has attracted the attention of researchers for years. Much of this research has been conducted in the Resource Constrained Project Scheduling Problem (RCPSP). The goal of this paper is to define new Genetic Algorithms Operators for a new a model of Resource Constrained Project Scheduling Problem with heterogeneous resources (operators). The model better resembles real-world projects and has more flexibility than previous models for manpower scheduling. Most RCPSP research uses Finish Time as a measure of the fitness of a solution. In this model the combination of Quality and Finish Time will be used. The goal will be to maximize the Quality and minimize the Finish Time. To solve the problem, the model will use Genetic Algorithms. New Crossover and Mutation operators will be implemented. These operators will attempt to create children with the same or higher Quality than their parents and will add the children the solution pool.
On a general approach to calculating the degree of crystallinity

Crystals nucleating at random positions are considered. A number of basic considerations lead to simple equations describing crystals that do not grow spherically but have different growth rates in different directions, as well as time dependent nucleation and growth rates. As applications, the respective equations are derived for two- and three-dimensional cases for thermal and athermal growth. A number of results obtained in the literature are derived as special cases, including Avrami's original equation. It is shown that the degree of crystallinity at any time is highest for perfectly parallel convex crystals, for which case an analytical solution is given. The power laws for the variation of the degree of crystallinity with time remain the same. A discussion is given as to what quantity would have to be computed in order to take into account the effect of any mutual orientation of crystals.
Ileal pouch-anal anastomosis without ileostomy

Thirty-seven patients underwent construction of a J-ileal pouch-anal anastomosis (IPAA) without temporary diverting ileostomy for chronic ulcerative colitis (CUC) (20 patients), familial adenomatous polyposis (FAP) (15 patients), indeterminate colitis (1 patient) and nonhereditary polyposis coli (1 patient) between 1981 and 1990. Seven of 20 CUC patients (35 percent) were on steroids at the time of hospital admission. The postoperative course of these patients was compared with that of a group of patients undergoing IPAA with ileostomy during that same time period and matched for age, sex, diagnosis, date of surgery, and steroid use. Eight patients (22 percent) in the group without ileostomy and four patients (11 percent) with ileostomy experienced one or more postoperative pouch-related complications. Complications requiring reoperation in patients without ileostomy occurred more frequently in patients either taking steroids or having previous pelvic radiation therapy. Functional results in patients undergoing one-stage procedures after a mean of 28 postoperative months were comparable to those in patients having staged procedures. Surgeons' criteria for a one-stage procedure in these patients should include absolute lack of tension on the anastomosis, good blood supply to the terminal ileum, good general health, and absence of recent intake of steroids at the time of surgery. We conclude that J-pouch construction with IPAA can be safely performed without diverting ileostomy, provided that these selection factors are taken into account.
A precorrected-FFT method for capacitance extraction of complicated 3-D structures

In this paper we present a new approach to three-dimensional capacitance extraction based on a precorrected FFT scheme. The approach is compared to the now commonly used multipole-accelerated algorithms for a variety of structures, and the new method is shown to have substantial performance and memory advantages.
Predictors of observer ratings of multicultural counseling competence in black, latino, and White American trainees

Using transcribed intake sessions of 52 counselor-client dyads, this study explored the relative contributions of (a) counselor and client race or ethnicity, (b) counselor-client racial or ethnic match, (c) previous academic training in multicultural counseling, and (d) self-reported multicultural counseling competence to observer ratings of trainees' multicultural counseling competence. Results revealed that (a) Black American and Latino American counselor trainees were rated as more multiculturally competent than their White American peers, and (b) prior multicultural training was positively predictive of observer-rated multicultural counseling competence. Implications of the findings for counselor training and practice are presented.
What Women Know that Men don't: Sex Differences in Determining the Truth Behind Deceptive Messages

While a good deal of research has been devoted to studying individual accuracy in detecting deceptiveness, a neglected issue involves the ability of individuals to accurately discern the truth that is obscured by deceptive messages. Methodological considerations have limited the generalizability of previous research findings in this area. Drawing upon a conceptualization of deception as a relational phenomenon, three hypotheses were developed and tested in a sample of 55 premarital romantic dyads. Subjects viewed a series of 12 videotaped segments of their partner who told the truth in half the segments and lied in half the segments. Results indicated that individual accuracy in ascertaining the underlying truth obscured by deception declines as individuals become more intimate. In addition, women were found to be consistently more accurate than men independent of level of relationship development.
Ureide catabolism in nitrogen-fixing legumes

Abstract The ureides, allantoin and allantoate, are the major nitrogen transport compounds in certain N 2 -fixing legumes. A novel pathway of allantoate catabolism that releases 4NH 3 , 2CO 2 and glyoxylate from allantoate, independent of urease action, has been proposed for soybeans.
Psychometric properties of a single-item assessing drunkenness to identify hazardous drinking: a replication study

AbstractBackground: The Alcohol Use Disorders Identification Test (AUDIT-C) is a commonly used scale to screen for hazardous alcohol use in various settings, including primary and emergency care settings. In such settings, brevity of effective screening tools is needed; therefore, single items have been developed and tested for detecting at-risk alcohol use behaviors.Purpose: This study replicates previous work validating the ability of a non-quantity-based single item assessing drunkenness to effectively identify signs of hazardous alcohol use.Methods: During fall 2013, alcohol use data were collected from 781 self-reported current drinkers. Concurrent validity of a drunkenness item to detect hazardous drinking behaviors was assessed against gender-based AUDIT-C thresholds. Convergent validity of the drunkenness item was assessed against biologic BrAC samples.Results: The single drunkenness item accounted for 0.856 of the area-under-the-received operating characteristics (ROC) curve for hazardous alcohol...
De novo assembly and characterization of tissue specific transcriptomes in the emerald notothen, Trematomus bernacchii

Background The notothenioids comprise a diverse group of fishes that rapidly radiated after isolation by the Antarctic Circumpolar Current approximately 14–25 million years ago. Given that evolutionary adaptation has led to finely tuned traits with narrow physiological limits in these organisms, this system provides a unique opportunity to examine physiological trade-offs and limits of adaptive responses to environmental perturbation. As such, notothenioids have a rich history with respect to studies attempting to understand the vulnerability of polar ecosystems to the negative impacts associated with global climate change. Unfortunately, despite being a model system for understanding physiological adaptations to extreme environments, we still lack fundamental molecular tools for much of the Nototheniidae family.
Cystic hepatic lesions: a review and an algorithmic approach.

OBJECTIVE. The purpose of this article is to review the different cystic hepatic lesions, with an emphasis on the imaging features that help to differentiate them, and to propose a practical algori...
Treating depression and anxiety in primary care. Closing the gap between knowledge and practice.

Depression is one of the most common and most debilitating psychiatric disorders. It is usually recognized when patients present with clear-cut psychiatric symptoms, but many depressed patients hav...
Cofermentation of glucose, xylose, and arabinose by genomic DNA-integrated xylose/arabinose fermenting strain of Zymomonas mobilis AX101.

Cofermentation of glucose, xylose, and arabinose is critical for complete bioconversion of lignocellulosic biomass, such as agricultural residues and herbaceous energy crops, to ethanol. We have previously developed a plas-mid-bearing strain of Zymomonas mobilis (206C[pZB301]) capable of cofer-menting glucose, xylose, and arabinose to ethanol. To enhance its genetic stability, several genomic DNA—integrated strains of Z. mobilis have been developed through the insertion of all seven genes necessay for xylose and arabinose fermentation into the Zymomonas genome. From all the integrants developed, four were selected for further evaluation. The integrants were tested for stability by repeated transfer in a nonselective medium (containing only glucose). Based on the stability test, one of the integrants (AX101) was selected for further evaluation. A series of batch and continuous fermentations was designed to evaluate the cofermentation of glucose, xylose, and L-arabinose with the strain AX101. The pH range of study was 4.5, 5.0, and 5.5 at 30°C The cofermentation process yield was about 84%, which is about the same as that of plasmid-bearing strain 206C(pZB301). Although cofermentation of all three sugars was achieved, there was a preferential order of sugar utilization: glucose first, then xylose, and arabinose last.
Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis

Abstract The sensitivity of rat cerebellar Purkinje cells to norepinephrine and to adrenergic antagonists and protagonists was studied by microiontophoresis. (1) Virtually all Purkinje cells respond to microiontophoresis of norepinephrine with a reduction in mean spontaneous discharge rate. (2) The effects of norepinephrine are reproduced by epinephrine, isoproterenol, amphetamine, and tyramine. (3) Responses to norepinephrine are blocked by the beta receptor antagonist, MJ-1999. (4) Desmethylimipramine, which blocks re-uptake of norepinephrine, markedly potentiates the response to this agent. (5) Norepinephrine, tyramine, amphetamine and MJ-1999 are effective in animals treated with 6-hydroxydopamine, indicating that their effects are not exerted on adrenergic presynaptic terminals. (6) These data support the hypothesis that norepinephrine is a Purkinje cell neurotransmitter.