cssi/SciSciGPT-SciSciNet huggingface dataset:
Why and How We Should Avoid Right Ventricular Apical Pacing

A large body of evidence has emerged recently about the harmful effects of chronic right ventricular (RV) apical pacing on left ventricular (LV) function leading to an increase in morbidity and mortality. Right ventricular apical pacing is unphysiologic because it produces aberrant LV depolarization, and in turn mechanical LV dyssynchrony with resultant long-term unfavorable hemodynamic and structural changes. Although the data about RV pacing-induced LV dysfunction outlined in this discussion are persuasive, its clinical applicability in pacemaker practice remains challenging. The ongoing transition to new pacing sites will succeed only with major technologic improvements in lead implantation. Meanwhile, pacing algorithms minimizing right ventricular pacing might be preferable at least in patients with sick sinus syndrome or non-permanent atrioventricular block. I N T R O D U C T I O N A large body of evidence has emerged recently about the harmful effects of chronic right ventricular (RV) pacing (mostly apical) on left ventricular (LV) function. The findings in several important trials correlate with the abnormalities in LV function previously documented in experimental animals subjected to RV pacing. RV pacing is unphysiologic because it produces aberrant LV depolarization, and in turn mechanical LV dyssynchrony with resultant long-term unfavorable hemodynamic (abnormal systolic and diastolic function) and structural changes. Faced with proof that RV apical pacing causes an increase in morbidity and mortality, the question arises as to whether we should continue pacing the apical RV as the preferred site or consider alternative sites to minimize LV dysfunction. Although the data about RV pacing-induced LV dysfunction outlined in this discussion are persuasive its clinical applicability in pacemaker practice remains challenging.
How muscle architecture and moment arms affect wrist flexion-extension moments

Abstract The purpose of this investigation was to determine how the moment arms and architecture of the wrist muscles influence their isometric moment-generating characteristics. A three-dimensional computer graphics model was developed that estimates the moment arms, maximum isometric forces, and maximum isometric flexion-extension moments generated by 15 muscles about the wrist over a range of wrist flexion angles. In combination with measurements of muscle strength, we used this model to answer three questions: (1) why is peak wrist flexion moment greater than peak extension moment, (2) why does flexion moment vary more with wrist flexion angle than does extension moment, and (3) why does flexion moment peak with the wrist in a flexed position? Analysis of the model revealed that the peak flexion moment is greater than the peak extension moment primarily because of the larger (110%) summed physiologic cross-sectional area of the flexors. The larger variation of flexion moment with flexion angle is caused mainly by greater variation of the moment arms of the major wrist flexors with flexion angle. The location of the peak flexion moment is determined by the wrist flexion moment arms (which tend to increase with wrist flexion) in combination with the force-length characteristics of these muscles.
DELETION ANALYSIS OF THE FIS PROMOTER REGION IN ESCHERICHIA COLI : ANTAGONISTIC EFFECTS OF INTEGRATION HOST FACTOR AND FIS

Fis is a small DNA-binding and -bending protein in Escherichia coli that is involved in several different biological processes, including stimulation of specialized DNA recombination events and regulation of gene expression. fis protein and mRNA levels rapidly increase during early logarithmic growth phase in response to a nutritional upshift but become virtually undetectable during late logarithmic and stationary phases. We present evidence that the growth phase-dependent fis expression pattern is not determined by changes in mRNA stability, arguing in favor of regulation at the level of transcription. DNA deletion analysis of the fis promoter (fis P) region indicated that DNA sequences from -166 to -81, -36 to -26, and +107 to +366 relative to the transcription start site are required for maximum expression. A DNA sequence resembling the integration host factor (IHF) binding site centered approximately at -114 showed DNase I cleavage protection by IHF. In ihf cells, maximum cellular levels of fis mRNA were decreased more than 3-fold and transcription from fis P on a plasmid was decreased about 3.8-fold compared to those in cells expressing wild-type IHF. In addition, a mutation in the ihf binding site resulted in a 76 and 61% reduction in transcription from fis P on a plasmid in the presence or absence of Fis, respectively. Insertions of 5 or 10 bp between this ihf site and fis P suggest that IHF functions in a position-dependent manner. We conclude that IHF plays a role in stimulating transcription from fis P by interacting with a site centered approximately at -114 relative to the start of transcription. We also showed that although the fis P region contains six Fis binding sites, Fis site II (centered at -42) played a predominant role in autoregulation, Fis sites I and III (centered at +26 and -83, respectively) seemingly played smaller roles, and no role in negative autoregulation could be attributed to Fis sites IV, V, and VI (located upstream of site III). The fis P region from -36 to +7, which is not directly regulated by either IHF or Fis, retained the characteristic fis regulation pattern in response to a nutritional upshift.
A comparison of olanzapine and risperidone on the risk of psychiatric hospitalization in the naturalistic treatment of patients with schizophrenia

Background Decreasing hospital admissions is important for improving outcomes for people with schizophrenia and for reducing cost of hospitalization, the largest expenditure in treating this persistent and severe mental illness. This prospective observational study compared olanzapine and risperidone on one-year psychiatric hospitalization rate, duration, and time to hospitalization in the treatment of patients with schizophrenia in usual care.
The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

Cellular responses to DNA damage are important determinants of both cancer development and cancer outcome following radiation therapy and chemotherapy. Identification of molecular pathways governing DNA damage signaling and DNA repair in response to different types of DNA lesions allows for a better understanding of the effects of radiation and chemotherapy on normal and tumor cells. Although dysregulation of the DNA damage response (DDR) is associated with predisposition to cancer development, it can also result in hypersensitivity or resistance of tumors to therapy and can be exploited for improvement of cancer treatment. We highlight the DDR pathways that are activated after treatment with radiation and different classes of chemotherapeutic drugs and describe mechanisms determining tumor sensitivity and resistance to these agents. Further, we discuss approaches to enhance tumor sensitivity to radiation and chemotherapy by modulating the DDR with a goal of enhancing the effectiveness of cancer therapies.
Proficient repair in chromatin remodeling defective ino80 mutants of Saccharomyces cerevisiae highlights replication defects as the main contributor to DNA damage sensitivity

Ino80 is an evolutionarily conserved member of the SWI2/SNF2-family of ATPases in Saccharomyces cerevisiae. It resides in a multiprotein helicase/chromatin remodeling complex, and has been shown to play a key role in the stability of replication forks during replication stress. Though yeast with defects in ino80 show sensitivity to killing by a variety of DNA-damaging agents, a role for the INO80 protein complex in the repair of DNA has only been assessed for double-strand breaks, and the results are contradictory and inconclusive. We report that ino80Delta cells are hypersensitive to DNA base lesions induced by ultraviolet (UV) radiation and methyl methanesulfonate (MMS), but show little (or no) increased sensitivity to the DNA double-strand break (DSB)-inducing agents ionizing radiation and camptothecin. Importantly, ino80Delta cells display efficient removal of UV-induced cyclobutane pyrimidine dimers, and show a normal rate of removal of DNA methylation damage after MMS exposure. In addition, ino80Delta cells have an overall normal rate of repair of DSBs induced by ionizing radiation. Altogether, our data support a model of INO80 as an important suppressor of genome instability in yeast involved in DNA damage tolerance through a role in stability and recovery of broken replication forks, but not in the repair of lesions leading to such events. This conclusion is in contrast to strong evidence for the DNA repair-promoting role of the corresponding INO80 complexes in higher eukaryotes. Thus, our results provide insight into the specialized roles of the INO80 subunits and the differential needs of different species for chromatin remodeling complexes in genome maintenance.
The continuous retina: image processing with a single-sensor artificial neural field network

Silicon retinas are typically implemented with multiple photosensors. Recent work with VLSI extended analog computers has led to a single-photosensor retina. An image focused on it generates a current gradient within the sensor that is discretized into an analog output vector, then classified by an artificial neural field network. A VLSI implementation recognizes several letters and fits on one MOSIS "TinyChip".
Minimizing Great-Circle Distance Ratios of Undesired and Desired Signal Paths on a Spherical Earth

Preventing interference among mobile radio (MR) nets often requires spectrum managers to observe channel-assignment rules based on minimum ratios of the great-circle distances traversed by desired and undesired (potentially interfering) signals. Finding the true minimum values of these ratios, rather than the simply computed worst-case estimates, is necessary to utilize the spectrum efficiently. This paper provides an analysis of the case where the MRs operate in or above circular service areas on the surface of a spherical Earth. The analysis provides an accurate and efficient way, which is less complicated than performing the calculations on the sphere, to compute true minimum distance ratios. The method uses stereographic projection to transform the original minimization problem into a simpler problem of minimizing a ratio of Euclidean distances, which is expressed as a function of a single real variable, over the boundaries of discs (i.e., circles) in the complex plane. In a large, complicated problem, this methodology has been shown to reduce the computational time by two thirds.
Three-Dimensional Kinematic and Microphysical Evolution of Florida Cumulonimbus. Part I: Spatial Distribution of Updrafts, Downdrafts, and Precipitation

Abstract This paper is the first in a three-part study that examines the kinematic and microphysical evolution of Florida cumulonimbus and focuses on the convective-to-stratiform transition of the storm. This first paper lays the groundwork for the subsequent papers by defining the problem under study, delineating the setting for the storm, and describing the spatial distribution of updrafts, downdrafts, and precipitation. High-resolution radar data of a typical line of storms associated with the Florida sea breeze is the centerpiece of this study. The high-resolution data reveal details of the internal structure of the squall line that were beyond the resolution of previous squall-line studies. Radar reflectivity filled in between cells at upper levels as the storm evolved. Reflectivity values were only weakly associated with updraft and downdraft magnitude. The updrafts and downdrafts in the storm tended to be irregular in their three-dimensional shape and less than 5 km in horizontal extent. At any giv...
The Remarkable Long-Run Conditional Predictability of US Real M1

This paper presents a useful approach to modeling US M1. Given the many failures in money modeling, the case for a meaningful relationship is made by forcing the model down two paths most fear to tread. First, a static cointegrating model is used to forecast over horizons well past the terminal estimation date, conditional on known non-M1 variables. Here "long horizon" is well over five years and as much as 25 years. In this long-horizon exercise the model tracks actual M1 remarkably well. Second, in shorter-run forecasts the cointegrating relationship is not folded into a dynamic error-correction form. Instead, the static model is forced to stand on its own when compared to a dynamic pure time series model. Here the static cointegration model forecasts with a smaller RMSE at a horizon of only six quarters. The model employs money and income scaled per household. There are three theoretical reasons for doing so. Scaling is necessary (a priori) to avoid inducing instability, miss-timing and trivial "self-cointegration". The cointegration model can be re-arranged to treat the price-level as a function of nominal money per household, real GDP per household, and an interest rate.
A Banks International Loan Policy And The Supply of Deposits

If the supply of domestic deposits is a function of the rate on deposits and the amount of loans extended domestically, and if domestic banks maximize profits, then the interest rate differential between two countries persists despite the lack of risk or government intervention. Furthermore, each domestic bank holds a combination of domestic and foreign loans although rates abroad are higher. By extending domestic loans, the bank attracts more deposits and incurs lower interest costs on these deposits.
INBREEDING EFFECTS IN A GYNODIOECIOUS POPULATION OF THE COLONIZING SPECIES TRIFOLIUM HIRTUM ALL.

The demographic consequences of one and two generations of selfing were examined in a gynodioecious population of rose clover (Trifolium hirtum). Seeds collected from a roadside population were used to create an experimental population that consisted of seeds of open-pollinated individuals (S0 ), and seeds obtained after one (S1 ) and two (S2 ) generations of selfing. Seeds from the three groups were equally likely to germinate. However, inbreeding effects were observed in the vigor and survivorship of the seedlings. The proportion of the transplanted seedlings that reached the reproductive stage was 0.42, 0.31, and 0.14 for the S0 , S1 , and S2 groups, indicating a reduction of 26% and 66% by one and two generations of selfing, respectively. Inbreeding effects on reproductive components of fitness were nonsignificant. Groups were compared by multiplicative fitness functions based on germination, survival to reproduction, and fecundity. The relative fitness of the S1 and S2 groups were 0.64 and 0.23 relative to the S0 group, representing a reduction in lifetime fitness of 36% and 77%, respectively. The differences in relative fitness among the groups were caused mainly by differences in survivorship. Thus, inbreeding depression is apparently an important factor in the maintenance of the gynodioecious breeding system in rose clover.
Facile and stabile linkages through tyrosine: bioconjugation strategies with the tyrosine-click reaction.

The scope, chemoselectivity, and utility of the click-like tyrosine labeling reaction with 4-phenyl-3H-1,2,4-triazoline-3,5(4H)-diones (PTADs) is reported. To study the utility and chemoselectivity of PTAD derivatives in peptide and protein chemistry, we synthesized PTAD derivatives possessing azide, alkyne, and ketone groups and studied their reactions with amino acid derivatives and peptides of increasing complexity. With proteins we studied the compatibility of the tyrosine click reaction with cysteine and lysine-targeted labeling approaches and demonstrate that chemoselective trifunctionalization of proteins is readily achieved. In particular cases, we noted that PTAD decomposition resulted in formation of a putative isocyanate byproduct that was promiscuous in labeling. This side reaction product, however, was readily scavenged by the addition of a small amount of 2-amino-2-hydroxymethyl-propane-1,3-diol (Tris) to the reaction medium. To study the potential of the tyrosine click reaction to introduce...
Paula Alexander. Corporate Social Irresponsibility. New York, NY: Routledge (2015) pp. 413

This book was intuitively appealing because of its title, or in business jargon its “hook”: Corporate Social IRresponsibility. In the foreword, which all should read, the author maps out the book's...
The Etiology and Research Progress of Acute Hemorrhagic Conjunctivitis

Acute hemorrhagic conjunctivitis(AHC)is a self-limiting epidemic viral infection of eyes caused by coxsakievirus group A type 24 variant,human enterovirus type 70 or adenovirus.It is characterized by abrupt onset of ocular pain,eyelid edema,foreign body sensation,rash,redness of eyes with sub-conjunctivital hemorrhages and epiphora.To augment the attention of AHC,this article reviewed the pathogenic characters,molecular epidemiology,epidemic status and characteristic,and provide strategy for acute hemorrhagic conjunctivitis prevention and control in China.
Where Have We Been, Where Are We Headed?: A Retrospective Review of Pynchon Criticism

Reading in Pynchon criticism to date is a good lesson in how irrelevant thematic studies can be to literary scholarship if they are not argued from within an understanding of the fiction, instead of being merely grafted onto it. Writing governs and defines its themes, and the critic must always have the process of the writing securely in mind before proposing to say what the writing means. This is particularly true of Pynchon's writing, which enacts the uncertainties of meaning. Because his books are in many respects about the interpretation of meaning, they resist efforts to impose a consistent pattern upon them. This is especially evident in those efforts which are entirely thematic and which attempt to discern the "message" of Pynchon's work without attending to its medium.
Abstract 303: Pre-operative Angiotensin Converting Enzyme Inhibitor use and outcomes in patients undergoing Isolated Coronary Artery Bypass Grafting

Background: The association between pre-operative use of angiotensin converting enzyme inhibitors (ACEI) and outcomes after coronary artery bypass grafting (CABG) remains controversial. Our aim was to study in-hospital outcomes after isolated CABG in patients on preoperative ACEI. Methods: We performed a retrospective analysis of 8,889 patients who underwent isolated CABG from year 2000 to 2011. Primary outcome was the incidence of major adverse events (MAE) defined as a composite of in-hospital mortality, post-operative renal dysfunction, myocardial infarction, stroke, and atrial fibrillation during index hospitalization. Secondary outcomes studied were the incidence of individual components comprising MAE. Logistic regression analysis was performed. Results (Table): Of the 8,889 patients, 3,983 (45%) were on pre-operative ACEI (“ACEI group”) and 4906 (55%) were not (“no ACEI group”). The overall incidence of MAE was 38.1% (n=1518) in the “ACEI group” versus 33.6% (n=1649) in “no ACEI group”. Pre-operative ACEI use was independently associated with increased risk of MAE (OR; 1.12, 95% CI; 1.02-1.23), most of which was driven by a statistically significant increase in post-operative renal dysfunction and atrial fibrillation. Pre-operative ACEI therapy was not associated with in-hospital mortality, post-operative myocardial infarction, or stroke. Conclusion: Preoperative ACEI use was associated with an increased risk of MAE post CABG, in particular post-operative renal dysfunction and atrial fibrillation. ![Graphic][1] [1]: /embed/inline-graphic-1.gif
Science: knowledge discovery in high-energy particle and nuclear physics

The fields of high energy and nuclear physics are faced with difficult challenges in terms of both the complexity and volume of data. This article contains a description of some of the tools that have been and will be used in physics data handling. It includes a description of the application of artificial neural network tools to the search for the top quark at the Fermi National Accelerator Laboratory. In addition, this article describes a new data handling framework, which will support deep drill-down data mining in physics analysis.
Thermal and crystallization histories of magmatic bodies by Monte Carlo inversion of Mg-Fe isotopic profiles in olivine

A random search modeling approach is introduced to retrieve the thermal histories of magmatic bodies from chemical and isotopic analyses of olivine crystals. The sample used for demonstration is an olivine phenocryst from Kilauea Iki lava lake, Hawaii. Random time-temperature ( t - T ) paths were used to model diffusion accompanying crystal growth. Although a large number of t - T paths yielded acceptable fits to the Mg/Fe chemical profiles measured in olivine, only a small fraction resulted in acceptable fits to the Mg-Fe isotopic profiles. The best-fit cooling path was close to the independently inferred cooling history of this sample. Use of isotopic profiles in minerals coupled with a random search method can be a powerful tool for recovering thermal histories of rocks with little geologic context.
A perception system for detecting brake levers in outdoor rail yard environments

A rail yard is a dangerous environment for humans to work in, primarily because of the possibility of serious injuries associated with moving rail cars, locomotives, and uneven terrain. For robots to act autonomously in such environments, there exists a need for a perception system that can act reliably under uncertain conditions. This uncertainty arises from multiple factors—uncontrolled lighting, uneven terrain, variability in appearance of objects, dynamic environment, noisy sensors, and controllers. In this paper, we present a perception system for a mobile robot that leverages information from various sensing modalities to act reliably in a partially observable environment. We show how our system can detect brake levers on a rail car, by fusing information from multiple detectors. We validate our approach by performing tests in an actual rail yard over multiple days and nights.
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency: immunologic studies on the mutant enzyme.

The Lesch-Nyhan syndrome is a bizarre, X-linked disease characterized by spasticity, choreoathetosis, self-mutilation, mental and growth retardation as well as hyperuricemia and hyperuricaciduria (Lesch and Nyhan,1964) which is due to a striking reduction of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity in all tissues of affected individuals (Seegmiller, Rosenbloom and Kelley, 1967; Rosenbloom, et al., 1967). We have examined hemolysates from 14 patients and autopsy tissue from one patient with the Lesch-Nyhan syndrome for their content of HGPRT activity and immunologically detectable HGPRT enzyme protein by using a monospecific rabbit antiserum prepared against a homogeneous preparation of normal human HGPRT (Arnold, Meade and Kelley, 1972).
INTRARENAL RENIN ANGIOTENSIN SYSTEM ACTIVATION: PATHOPHYSIOLOGIC AND THERAPEUTIC IMPLICATIONS IN ACUTE DECOMPENSATED HEART FAILURE

Introduction: The Renin Angiotensin System (RAS) plays a pivotal role in mediating Cardiorenal Syndrome in acute decompensated heart failure (ADHF) and is one of the most targeted pathways in the treatment of HF. Human Angiotensinogen (AGT) is the precursor for all angiotensin (ANG) isoforms,
Secondary breast cancer (s-BC) after hematopoietic cell transplantation (HCT) for leukemia: Role of total body irradiation (TBI).

1592 Background: s-BC after conventional chest radiation for histologically distinct cancer is well-recognized, and has resulted in radiologic screening recommendations by American Cancer Society. ...
Outcomes of first-line treatment for chronic lymphocytic leukemia (CLL) with 17p deletion (del17p).

7102 Background: Patients (pts) with relapsed CLL bearing del17p are very high-risk for poor clinical outcomes. We summarize outcomes for first-line treatment of del17p CLL. Methods: We identified ...
A Task-Level Model of Distibuted Computation for Sensory-Based Control of Complex Robot Systems

Abstract We describe the development of a task-level model of distributed computation specifically designed for complex robot systems. We start by describing two fundamental problems which characterize the complex robot domain, and then describe four examples by which our model can be judged. Emphasizing that the formal exploration of behavior is as important as the specification of behavior, we describe the syntax and semantics of our model. Noting that our emphasis in this paper is on representation, we detail the implementation of each of the four examples introduced earlier. We conclude by analysing our implementations and outlining future work on this model.
Emergence of Neo-Islamic Economic Capital in Turkey

The third and fourth chapters deal with the rise of Islamic economic and political capital in modern Turkey, a topic which has been the subject of several academic studies in recent years. The main arguments of these chapters are that the neo-liberal free market policies of Turgut Ozal’s Motherland Party created conducive conditions for the accumulation of first economic and then political capital in the 1980s. Contrary to the accepted wisdom, the new class was not necessarily an autonomous class but rather has been created thanks to the policies of the Motherland Party. It was the 1980s when the Islamists who were excluded from the creation of the national bourgeoisie came back into the picture. The formation of Islamic financial institutions opened up new opportunity spaces for Islamic businessmen. Interest-free special finance institutions served in two ways in the process of Islamic economic capital accumulation. First, they attracted the savings of religious people who did not use conventional banks. Through Islamic financial institutions, these “excluded” people were integrated into the system. Moreover, these institutions brought new funds to the system. Second, they provided funds to Islamic business circles that did not use banks for capital loans, hence contributing to their development.
The assembled transcriptome of the adult horn fly, Haematobia irritans .

Abstract The horn fly, Haematobia irritans irritans (Linnaeus, 1758; Diptera: Muscidae), a hematophagous external parasite of cattle, causes considerable economic losses to the livestock industry worldwide. This pest is mainly controlled with insecticides; however, horn fly populations from several countries have developed resistance to many of the products available for their control. In an attempt to better understand the adult horn fly and the development of resistance in natural populations, we used an Illumina paired-end read HiSeq and GAII approach to determine the transcriptomes of untreated control adult females, untreated control adult males, permethrin-treated surviving adult males and permethrin + piperonyl butoxide-treated killed adult males from a Louisiana population of horn flies with a moderate level of pyrethroid resistance. A total of 128,769,829, 127,276,458, 67,653,920, and 64,270,124 quality-filtered Illumina reads were obtained for untreated control adult females, untreated control adult males, permethrin-treated surviving adult males and permethrin + piperonyl butoxide-treated killed adult males, respectively. The de novo assemblies using CLC Genomics Workbench 8.0.1 yielded 15,699, 11,961, 2672, 7278 contigs (≥ 200 nt) for untreated control adult females, untreated control adult males, permethrin-treated surviving adult males and permethrin + piperonyl butoxide-treated killed adult males, respectively. More than 56% of the assembled contigs of each data set had significant hits in the BlastX (UniProtKB/Swiss-Prot database) (E
Spanish transfer effects in the English writing of elementary school students

L'article examine les influences du langage specifique sur les eleves en espagnol L1 et en anglais L1 ecrivant en anglais. Un total de 545 textes (311 en anglais et 234 en espagnol) sont analyses sur des traits linguistiques varies tels que l'utilisation du pronom, les verbes modaux, la coordination et la subordination. Les resultats confirment un certain nombre d'affirmations anterieurs sur l'effet de transfert en espagnol lors de l'ecriture en anglais, particulierement en ce qui concerne l'utilisation d'un style elabore
The Effects of Three Physical and Vocal Warm-up Procedures on Acoustic and Perceptual Measures of Choral Sound: Study Replication With Younger Populations.

Summary Objective The purpose of this study was to replicate a previous investigation to assess with two intact children's choirs and a high school choir the potential effects of three choral warm-up procedures (vocal-only, physical-only, physical/vocal combination) on acoustic and perceptual measures of choral sound. Methods The researchers tested three videotaped, 5-minute, choral warm-up procedures on two children's and one high school choir. After participating in a warm-up procedure, each choir was recorded singing a folk song for long-term average spectra and pitch analysis. Singer participants responded to a questionnaire about preferences after each warm-up procedure. Warm-up procedures and recording sessions occurred during each choir's regular rehearsal time and in each choir's regular rehearsal space during three consecutive rehearsals. Results Long-term average spectra results demonstrated more resonant singing after the physical/vocal warm-up for two of the three choirs. Pitch analysis results indicated that two of the three choirs sang “in-tune” after participating in the physical/vocal warm-up and two choirs sang “in-tune” after participating in the physical-only warm-up. Singer questionnaire responses showed a preference for the physical/vocal combination warm-up, and singer ranking of the three procedures indicated the physical/vocal warm-up as the most favored for readiness to sing. Conclusions This study replication indicates similar conclusions as the original investigation with university choruses: a combination choral warm-up that includes both physical and vocal aspects is preferred by singers of all ages, enables more resonant singing, and more in-tune singing. Findings from these investigations provide choral educators with compelling information concerning efficient and effective choral warm-up procedures.
Acute Lymphoblastic Leukemia in the Older Adult

Acute lymphoblastic leukemia (ALL) in older adults presents a real challenge as a result of adverse disease biology and comorbidities that preclude delivering curative regimens. Conventional chemotherapy approaches have generally yielded unsatisfactory results in older patients with ALL as a result of excessive induction mortality, chemotherapy resistance of the leukemia, and the need to omit or dose reduce key drugs during the course of therapy because of adverse effects. Philadelphia chromosome-positive ALL represents about a quarter of newly diagnosed older adults, and the striking single-agent activity and excellent safety profile of tyrosine kinase inhibitors has allowed incorporation of these agents into therapy, significantly improving the outcome of older adults with Philadelphia chromosome-positive ALL. Allogeneic hematopoietic cell transplantation using reduced-intensity conditioning is a potentially curative approach in the older adult with ALL, and ironically, it may be better tolerated than intensive combination chemotherapy in a subset of older patients with ALL. Immunotherapies such as chimeric antigen receptor-modified T-cells, the bispecific T-cell-engaging antibody targeting CD19 (blinatumomab), and the antibody-drug conjugate targeting CD22 (inotuzumab) have shown safety and exceptional activity even in advanced ALL, and the efficacy of these agents has been observed irrespective of patient age. Several promising studies tailored specifically toward older adults with ALL are ongoing, with the majority of them incorporating novel immunotherapies, targeted therapies, or third-generation tyrosine kinase inhibitors into the front-line treatment regimen.
Managing Privilege and Access on Federated Edge Platforms

The SLATE (Services Layer at the Edge) platform supports collaborative, multi-institution scientific computing through federation of containerized edge services. This paper considers issues of trust between resource providers and developers of orchestrated services which span administrative domains. The context for discussion is the SLATE federation architecture and application deployment pattern. The major features are a custom central API server which implements the federation, partitioning of user and group applications on edge clusters, and a curated catalog of applications which can be installed within the federation.
RECENT DEVELOPMENTS FOR THE PSMG MULTISCALE METHOD

In this paper we discuss new developments for the PSMG multiscale method, which we have introduced previously as an efficient PDE solver for massively parallel architectures.
Emergency Department Closures And Openings: Spillover Effects On Patient Outcomes In Bystander Hospitals

High-occupancy hospitals may be sensitive to neighboring emergency department (ED) closures and openings, as they already operate at or near capacity. We conducted a retrospective analysis using da...
Neuromemristive Multi-Layer Random Projection Network with On-Device Learning

This paper proposes a neuromemristive multi-layer neural network with on-device learning. The proposed system is studied within the context of a feedforward multi-layer random projection network, where the core learning is modeled by a stochastic gradient descent simplified for memristor crossbar integration. Two random projection network topologies are explored for binomial and multinomial datasets. A detailed study on the resiliency of the networks in the presence of device failure is performed. The topology with softmax output layer exhibits stability and better resiliency in performance after experiencing a device failure. It is shown that this topology can regain full performance after experiencing 30% stuck-at-faults, with 2x increase in the hidden layer neurons.
Breast-Related Quality of Life in Young Reduction Mammaplasty Patients: A Long-Term Follow-Up Using the BREAST-Q.

Background:Reduction mammaplasty is the most effective means of improving symptoms of macromastia. Although studies have shown lasting benefits in adult patients, there is a paucity of data that explore this topic in young patients. In this study, the long-term satisfaction and well-being of young r
My Leadership Chronology and What It Taught Me

Leadership is more about the people with whom you work than about you, and it is more about what you learn from experience than just what you experience. My experiences taught me what to do as a leader, and sometimes, and perhaps more importantly, what not to do. This chapter describes the chronological sequence of experiences that taught me, and it details what I learned for each of those experiences.
Latent class analysis of early onset of behavior problems: relevance for predicting offending across the life-course

Research has demonstrated the importance of early-life behavioral issues for predicting risk for offending throughout the life-course. However, there has yet to be any study that has examined how e...
Anxiety impacts rheumatoid arthritis symptoms and health-related quality of life even at low levels.

OBJECTIVES We explored the burden of symptoms of anxiety and depression on health-related quality of life (HRQL) in patients with rheumatoid arthritis (RA). METHODS Adults with RA participating in an observational cohort completed PROMIS tests of depression, anxiety, fatigue, physical function (PF), pain interference (PI), sleep disturbance, and participation in social roles and activities at the baseline visit. Clinical measures of disease status were also obtained. We used ANOVA and partial correlation adjusting for the swollen joint count (SJC) to examine associations of anxiety and depression with other aspects of HRQL. Mild and moderate-severe anxiety were defined as T-scores ≥55.4 and ≥ 62.3 and mild and moderate-severe depression was defined as ≥52.5 and ≥58.6 based on previous validated clinical thresholds. Multivariable linear regression (MVR) was used to identify predictors of emotional distress with a subset analysis of those in remission/low disease activity. RESULTS Of 196 RA participants, 18% had mild anxiety, 9% had moderate-severe anxiety, 18% had mild depression, and 14% had moderate-severe depression symptoms. Anxiety and depression scores were associated with significantly worse mean scores across HRQL domains (p <0.05). In MVR, depression (β=0.75, p<0.001), PF (β=0.14, p=0.024) and fatigue (β=0.15, p=0.015) predicted higher anxiety levels, whereas only anxiety predicted higher depression levels (β=0.70, p=<0.001). In subset analysis, PF no longer predicted higher anxiety levels. CONCLUSIONS Emotional distress is common in RA, even when disease is well controlled, with considerable impacts on other aspects of HRQL even at mild levels.
Closely Spaced Paralllel Operations (CSPO) Dependent Departures: Concept and Initial Assessments

The Federal Aviation Administration currently develops and implements capabilities of its Next Generation Air Transportation System (NextGen). Key benefits include increased airport capacity by reducing separation standards and enabling new operations in lower visibility conditions. NextGen's Closely Spaced Parallel Operations (CSPO) program investigates the operational concepts and performance requirements that enable the implementation of innovative standards and procedures for operations on closely spaced parallel runways across the National Airspace System. They include the CSPO Dependent Departure concept which aims to increase the operational efficiencies of departure operations. When operations are conducted under Instrument Flight Rules, departures from runways with centerlines spaced less than 2,500 feet currently require application of separation identical to the separation required for departures conducted on the same runway. The Dependent Departure concept capitalizes on CSPO runway spacing to enable lower initial separation requirements, effectively reducing the time interval applied between departing aircraft. This paper presents the CSPO Dependent Departure concept and its application to a range of operational scenarios. It describes the methodology developed for leveraging in-service data of actual operations to define reduced initial spacing requirements and support safety assessments of the operations. The results suggest, depending on the operational scenario, CSPO Dependent Departures with 15 to 52-percent reduced departure time intervals will meet the target level of safety established for the operations from a collision risk perspective.
INTERFEROMETRIC UPPER LIMITS ON MILLIMETER POLARIZATION OF THE DISKS AROUND DG TAU, GM AUR, AND MWC 480

Millimeter-wavelength polarization measurements offer a promising method for probing the geometry of magnetic fields in circumstellar disks. Single dish observations and theoretical work have hinted that magnetic field geometries might be predominantly toroidal, and that disks should exhibit millimeter polarization fractions of 2–3%. While subsequent work has not confirmed these high polarization fractions, either the wavelength of observation or the target sources differed from the original observations. Here we present new polarimetric observations of three nearby circumstellar disks at 2 ′′ resolution with the Submillimeter Array (SMA) and the Combined Array for Research in Millimeter Astronomy (CARMA). We reobserve GM Aur and DG Tau, the systems in which millimeter polarization detections have been claimed. Despite higher resolution and sensitivity at wavelengths similar to the previous observations, the new observations do not show significant polarization. We also add observations of a new HAeBe system, MWC 480. These observations demonstrate that a very low (.0.5%) polarization fraction is probably common at large (&100AU) scales in bright circumstellar disks. We suggest that high-resolution observations may be worthwhile to probe magnetic field structure on linear distances smaller than the disk scale height, as well as in regions closer to the star that may have larger MRI-induced magnetic field strengths. Subject headings: magnetic fields – polarization – protoplanetary disks – stars: formation – stars: individual(DG Tau, GM Aur, MWC 480)
Journal of Community Engagement and Higher Education: Changes in Perspective

This article reflects on recent changes that have and will continue to affect the Journal of Community Engagement and Higher Education.
Transcending marginalization in knowledge development

Quality care requires a body of knowledge that reflects the experiences and the responses of the marginalized populations to health and illness, and requires demarginalization of nursing knowledge. We argue the significance of developing an understanding of people who are marginalized, and organize our arguments and discussions into four sections: (i) developing knowledge that is not marginalizing; (ii) developing knowledge about marginalized populations; (iii) integrating nursing knowledge and making it visible; and (iv) the future of research enterprise. We propose that nurses critically consider strategies and processes to deal with and transcend marginalization of populations and of nursing knowledge.
Expression and Localization of Androgen Receptor in the R-3327 Dunning Rat Prostatic Adenocarcinoma

Abstract The Dunning R-3327 rat prostatic adenocarcinoma and its sublines have been developed as a model system to study prostate tumor progression. We have used this system to study the changes in androgen receptor (AR) and AR mRNA expression which occur during tumor progression from androgen dependent to androgen independent growth. Dorsal prostate and all tumor sublines contained a 10-kilobase AR mRNA on Northern blot analysis. The levels of AR mRNA in each subline compared to dorsal prostate (100%) were: H (75%) > G (48%) > HI (25%) > HI-F = AT-1 = AT-3 = MAT-Lu = MAT-Ly-Lu =
Pseudarthrosis of the Clavicle

Twenty ununited fractures of the clavicle have been reviewed. The factors predisposing to pseudarthrosis were severe trauma with persistent gross displacement of the fragments, primary open reduction with inadequate internal fixation, and insufficient external fixation. Fractures of the middle third of the clavicle may be more prone to non-union. If painful symptoms persist in the presence of non-union, intramedullary fixation and an onlay bone graft are indicated. An onlay iliac-bone graft fixed with screws combined with cancellous iliac bone packed between the ends would appear to give the best results. A spica or figure-of-eight plaster encasement should be used as external immobilization.
Goal Setting:: A Five-Step Approach to Behavior Change

The purpose of a superordinate or overarching goal is to capture the imagination, and hence to galvanize people to take action. A superordinate goal reflects the power of language expressed in ways that convey to people something they can believe in. Hence a superordinate goal facilitates self-management. Bottom-up goals are frequently more powerful than those that are primarily top-down because they are expressed in the language of the employees. Whereas a superordinate goal appeals primarily to affect, goal setting is first and foremost a cognitive variable. The purpose of goal setting is to make the superordinate goal concrete, to move it from emotional rhetoric to concrete action steps. Goals are also effective because they provide people with a challenge as well as feelings of accomplishment when progress is made toward goal attainment. Goals even provide meaning to otherwise meaningless tasks.
Phase II Evaluation of Thalidomide in Patients With Metastatic Breast Cancer

PURPOSE: To determine the efficacy, safety, pharmacokinetics, and effect on serum angiogenic growth factors of two dose levels of thalidomide in patients with metastatic breast cancer. PATIENTS AND METHODS: Twenty-eight patients with progressive metastatic breast cancer were randomized to receive either daily 200 mg of thalidomide or 800 mg to be escalated to 1,200 mg. Fourteen heavily pretreated patients were assigned to each dose level. Each cycle consisted of 8 weeks of treatment. Pharmacokinetics and growth factor serum levels were evaluated. RESULTS: No patient had a true partial or complete response. On the 800-mg arm, 13 patients had progressive disease at or before 8 weeks of treatment and one refused to continue treatment. The dose was reduced because of somnolence to 600 mg for five patients and to 400 mg for two and was increased for one to 1,000 mg and for four to 1,200 mg. On the 200-mg arm, 12 patients had progressive disease at or before 8 weeks and two had stable disease at 8 weeks, of who...
The Grothendieck group of a Hopf algebra

Abstract Let H be a cosemisimple Hopf algebra over an algebraically closed field k . We show that if H contains a simple subcoalgebra of dimension 4, then H contains either a Hopf subalgebra of dimension 2, 12, or 60, or a simple subcoalgebra of dimension n 2 for each positive integer n . In particular, if H is finite dimensional, then it has even dimension.
A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) versus penile nerve block for pain relief during circumcision.

Abstract Objective: We set out to compare a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) to dorsal penile nerve block with lidocaine for anesthesia during circumcision. Study Design: In a double-blind study, term newborns were randomized to local anesthetic cream and sodium chloride solution dorsal penile nerve block (n = 31) or to placebo cream and lidocaine dorsal penile nerve block (n = 29). Pain was assessed by determination of heart rate, respiratory rate, and behavioral distress scoring. Group differences were evaluated with repeat-measures analyses of variance. Results: Distress scores and heart rates were significantly higher in the eutectic mixture group than in the lidocaine group. Respiratory rates were higher in the eutectic mixture group but did not reach statistical significance. Conclusions: Distress scores and heart rates were significantly higher in infants treated with the anesthetic mixture than in infants treated with lidocaine. Dorsal penile nerve block with lidocaine is a more efficacious means of providing anesthesia for neonatal circumcision than the mixture of local anesthetics. (Am J Obstet Gynecol 1999;181:1506-11.)
Regaining single sign-on taming the beast

It has been our effort at Ringling school to provide our campus community with the capability to uniformly access resources across multiple platforms. Empowering the user with a single sign-on capability has multifold benefits. It greatly improves user experience and relieves the user from the burden of remembering multiple user-id and password pairs. On the administrative side, help desk costs are noticeably reduced and security improved, as users are not tempted to 'store' multiple passwords in written form.In the Fall of 1998 we implemented a single sign-on framework that utilized Sun RPC to synchronize accounts and passwords across multiple systems on the network. Our approach was easy to deploy, did not require any client level software and we did not introduce a single point of failure.It is our objective to consolidate user administration systems by adhering to a Light Weight Directory Access Protocol (LDAP) based meta-directory model while preserving a common, single end-user authentication information and the coordinated management of user account information. Therefore, we are implementing a new single sign-on system that utilizes LDAP and SUN RPC protocols. Our approach is secure, does not store passwords and does not introduce a single point of failure. Password resetting can be done seamlessly and transparently without the need for additional client software.