cssi/SciSciGPT-SciSciNet huggingface dataset:
End Effects in Twisted Cord‐Rubber Composites

Abstract This paper investigates the cord‐matrix load transfer problem in twisted cord‐rubber composites. The central feature of the study is to ascertain the polarizing effects of twist‐induced coupling of the axial loads and torque. Particular emphasis is given to the end problem, namely the transition between the axial‐circumferential shear stress‐dominated end region and the axial normal stress and torque‐controlled far‐from‐end zone. This is achieved through the development of both a closed form analytic formulation and its corroboration by a detailed finite element simulation.
What Makes Marketing Academicians Successful? An Assessment of Teaching, Publishing, and Service:

A survey was conducted of marketing academicians. In it, an attempt was made to determine whether the components of the teaching profession (i.e., research, teaching, and service) are important predictors of income. The results indicate that publishing is most likely to produce the greatest income rewards, not teaching, and certainly not service.
Software Science Revisited: A Critical Analysis of the Theory and Its Empirical Support

The theory of software science was developed by the late M. H. Halstead of Purdue University during the early 1970's. It was first presented in unified form in the monograph Elements of Software Science published by Elsevier North-Holland in 1977. Since it claimed to apply scientific methods to the very complex and important problem of software production, and since experimental evidence supplied by Halstead and others seemed to support the theory, it drew widespread attention from the computer science community.
4 modalities of periodontal treatment compared over 5 years

The purpose of the present study was to assess in a clinical trial over 5 years the results following 4 different modalities of periodontal therapy (pocket elimination or reduction surgery, modified Widman flap surgery, subgingival curettage, and scaling and rool planing). 90 patients were treated. The treatment methods were applied on a random basis to each of the 4 quadrants of the dentition. The patients were given professional tooth cleaning and oral hygiene instructions every 3 months. Pocket depth and attachment levels were scored once a year. 72 patients completed the 5 years of observation. Both patient means for pocket depth and attachment level as well as % distribution of sites with loss of attachment greater than or equal to 2 mm and greater than or equal to 3 mm were compared. For 1-3 mm probing depth, scaling and root planing, as well as subgingival curettage led to significantly less attachment loss than pocket elimination and modified Widman flap surgery. For 4-6 mm pockets, scaling and root planing and curettage had better attachment results than pocket elimination surgery. For the 7-12 mm pockets, there was no statistically significant difference among the results following the various procedures.
On the very idea of a system dynamics model of Kuhnian science

Validation strategies for models of theories have received scant attention in the system dynamics literature. Yet if system dynamics is to be an effective tool for, evaluating the dynamic consistency of theoretical systems, such strategies will need to be developed. This article illustrates how such validation might take place by analyzing an already published model of Thomas S. Kuhn's theory of scientific revolutions. The results indicate that the model, while capturing many important aspects of Kuhnian science, distorts certain fundamental features of the theory, in particular the process of paradigm change. The article concludes by discussing some of the problems associated with incorporating truly Kuhnian paradigm change into any system dynamics model.
Heparanase expression and TrkC/p75NTR ratios in human medulloblastoma

Medulloblastoma (MB), the most devastating and common brain tumor in children, is highly invasive and extremely difficult to treat. Identifying the properties of MB tumors that cause them to invade and metastasize is therefore imperative for the development of novel treatments. We performed investigations to elucidate prognostic implications of heparanase (HPSE-1) and TrkC/p75NTR expression in MB using formalin-fixed, paraffin-embedded (FFPE) MB clinical specimens from children aged 1–19 years. Expressions of p75NTR and HPSE-1 correlated with each other (Pearson’s correlation R = 0.899; P < 0.0001; R2 = 81%; n = 14). In addition, TrkC:p75NTR ratios correlated with MB meningeal spread (R = 0.608; P = 0.0212; R2 = 37%; n = 14). Secondly, using antibodies specific to TrkC and HPSE-1, we carried out immunohistochemistry (IHC) on 22 human MB tissue samples. IHC reaction scores revealed a significant expression of HPSE-1 in 76% of MB tissues from children aged 3 years and older (P = 0.0490; n = 17) while TrkC immunoreactivity was detected in 71% of these patient samples. Of note, TrkC was significantly present in 100% of MB female patients (P = 0.0313; n = 6). These studies support the role of p75NTR and HPSE-1 as two novel molecular determinants involved in the biology and clinical progression of MB.
Empirical Validation of Design Principles for Survivable System Architecture

Survivability, the ability of a system to minimize the impact of a finite-duration disturbance on end-user value delivery, is increasingly recognized beyond military contexts as an enabler of maintaining system performance in operational environments characterized by dynamic disturbances. Seventeen general design principles are proposed to inform concept generation of survivable system architectures. Six of these design principles focus on a survivability strategy of susceptibility reduction: (1.1) prevention, (1.2) mobility, (1.3) concealment, (1.4) deterrence, (1.5) preemption, and (1.6) avoidance. Eleven of the principles focus on vulnerability reduction: (2.1) hardness, (2.2) redundancy, (2.3) margin, (2.4) heterogeneity, (2.5) distribution, (2.6) failure mode reduction, (2.7) fail-safe, (2.8) evolution, (2.9) containment, (2.10) replacement, and (2.11) repair. In this paper, the completeness, taxonomic precision, and domain-specific applicability of the design principle framework is empirically tested through case applications to survivability features of the F-16C combat aircraft and Iridium satellite system. Integrating results of these two tests with previous tests (e.g., UH-60A Blackhawk helicopter, A-10A aircraft), the validity of the design principle framework for aerospace systems is demonstrated.
Impact tsunami Eltanin

Employing classical tsunami theory and elementary assumptions about the initial shape of impact cavities, we compute tsunami from the Eltanin asteroid collision at 2.15 Ma. An Eltanin impactor 4 km in diameter would have blown an initial cavity as deep as the ocean and 60 km wide into the South Pacific and delivered a 200–300 m high tsunami to the Antarctic Peninsula and the southern tip of South America 1200–1500 km away.New Zealand, 6000 km distant, would have met 60 m waves.Generalizing these results to other size impactors, we fit simplified tsunami attenuation laws to maximum tsunami heights extracted from the full-wave calculations.If Eltanin was 1 km in diameter instead of 4 km, its waves would have been at least five times smaller.An asteroid the size of Chicxulub (10 km diameter), had it fallen into water deeper than 1000 m, would have sent a 100 m tsunami out to 4000 km distance, even if shoaling amplifications are neglected. r 2002 Elsevier Science Ltd.All rights reserved.
OSCILLATOR STRENGTHS FOR DIPOLE-ALLOWED FINE-STRUCTURE TRANSITIONS IN Fe XIII

I thank Professor Anil K. Pradhan for comments. This work was partially supported by a grant from the NSF for the Iron Project and by the NASA UV and Optical Astrophysical Program. Computations were carried out on the Cray T-94 at the Ohio Supercomputer Center.
Altitude Control of a Single Degree of Freedom Flapping Wing Micro Air Vehicle

A control strategy is proposed for a minimally actuated flapping wing micro air vehicle. The Harvard RoboFly vehicle accomplished the first takeoff of an insect scale flapping wing aircraft. This flight demonstrated the capability of the aircraft to accelerate vertically while being constrained by guide-wires to avoid translation and rotation in the other five degrees of freedom. The present work proposes an altitude control scheme that would enable a similar vehicle under the same constraints to hover and track altitude commands. Using a blade element-based aerodynamic model and cycle averaging, it will be shown that altitude control of such an aircraft can be achieved. The RoboFly makes use of a single bimorph piezoelectric actuator that symmetrically varies the angular displacement of the left and right wings in the stroke plane. The wing angle-of-attack variation is passive and is a function of the instantaneous angular velocity of the wing in the stroke plane. The control law is designed to vary the frequency of the wing beat oscillations to control the longitudinal body-axis force which is used to achieve force equilibrium in hover and acceleration when tracking time-varying altitude commands.
A Field Guide to Genomics Research

Portraying high-throughput genomics research as a wild frontier, Andrea Bild and colleagues use caricatures to highlight common pitfalls in genomic research and provide recommendations for navigating this terrain.
Natural variability in forests of the Grand Canyon, USA

Aim Compare contemporary with pre-fire-disruption forest structures, assessing the influence of factors that caused ecological change and evaluating remote sites as relatively natural areas. Location Grand Canyon National Park contains the largest never-harvested and longterm ungrazed forest ecosystem in Arizona, providing valuable sites for measuring natural variability. However, anthropogenic disruption of natural fire regimes since Euro-American settlement c. 1880 has led to changes in forest structure.
Neutralino dark matter as the source of the WMAP haze

Previously, it has been argued that the anomalous emission from the region around the Galactic Center observed by WMAP, known as the 'WMAP Haze', may be the synchrotron emission from relativistic electrons and positrons produced in dark matter annihilations. In particular, the angular distribution, spectrum, and intensity of the observed emission are consistent with the signal expected to result from a weakly interactive massive particle with an electroweak-scale mass and an annihilation cross section near the value predicted for a thermal relic. In this article, we revisit this signal within the context of supersymmetry and evaluate the parameter space of the constrained minimal supersymmetric standard model. We find that, over much of the supersymmetric parameter space, the lightest neutralino is predicted to possess the properties required to generate the WMAP Haze. In particular, the focus point, A-funnel, and bulk regions (in which the neutralino annihilation cross section is of the order of 3x10{sup -26} cm{sup 3}/s) typically predict a neutralino with a mass, annihilation cross section, and dominant annihilation modes which are within the range required to produce the observed features of the WMAP Haze. The stau-coannihilation region (in which the annihilation is suppressed), in contrast, is disfavored as anmore » explanation for the origin of this signal.« less
Reaction Mechanism, Evolutionary Analysis, and Role of Zinc in Drosophila Methionine-R-sulfoxide Reductase *

Methionine residues in proteins are susceptible to oxidation, and the resulting methionine sulfoxides can be reduced back to methionines by methionine-S-sulfoxide reductase (MsrA) and methionine-R-sulfoxide reductase (MsrB). Herein, we have identified two MsrB families that differ by the presence of zinc. Evolutionary analyses suggested that the zinc-containing MsrB proteins are prototype enzymes and that the metal was lost in certain MsrB proteins later in evolution. Zinc-containingDrosophila MsrB was further characterized. The enzyme was found to employ a catalytic Cys124 thiolate, which directly interacted with methionine sulfoxide, resulting in methionine and a Cys124 sulfenic acid intermediate. A subsequent reaction of this intermediate with Cys69 generated an intramolecular disulfide. Dithiothreitol could reduce either the sulfenic acid or the disulfide, but the disulfide was a preferred substrate for thioredoxin, a natural electron donor. Interestingly, the C69S mutant could complement MsrA/MsrB deficiency in yeast, and the corresponding natural form of mouse MsrB was active with thioredoxin. These data indicate that MsrB proteins employ alternative mechanisms for sulfenic acid reduction. Four other conserved cysteines in DrosophilaMsrB (Cys51, Cys54, Cys101, and Cys104) were found to coordinate structural zinc. Mutation of any one or a combination of these residues resulted in complete loss of metal and catalytic activity, demonstrating an essential role of zinc in Drosophila MsrB. In contrast, two conserved histidines were important for thioredoxin-dependent activity, but were not involved in zinc binding. ADrosophila MsrA gene was also cloned, and the recombinant enzyme was found to be metal-free and specific for methionineS-sulfoxide and to employ a similar sulfenic acid/disulfide mechanism.
Properties of optimal, compaction filters in subband coding

Optimum compaction filters find application in the design of orthonormal subband coders with maximum coding gain. The compaction gain for a process is defined, and a number of its properties studied. Bounds on the compaction gain are established, and the conditions for the attainment of these bounds are specified in terms of the input power spectrum. Finally, the behavior of the optimum compaction gain as a function of M (the number of channels in a subband coder) is also addressed.
Silence, Attribution Accuracy and Virtual Environments: Implications for Developers and Facilitators

This research studied virtual teams using an Internet based software tool to collaborate to explore the question: what virtual or physical environment constructs influence the attribution accuracy of silence among virtual team members? Contextual information relating to team members was given to one half the teams and the other half was not given the cues. It was found that team members given the cues made more accurate attributions as to the meanings of silence than the team members using the software without the cues. Based on these findings we make recommendations to designers, facilitators and users of groupware tools.
Near-perfect-reconstruction pseudo-QMF banks

A novel approach to the design of M-channel pseudo-quadrature mirror filter (QMF) banks is presented. In this approach, the prototype filter is constrained to be a linear-phase spectral-factor of a 2Mth band filter. As a result, the overall transfer function of the analysis/synthesis system is a delay. Moreover, the aliasing cancellation (AC) constraint is derived such that all the significant aliasing terms are canceled. Consequently, the aliasing level at the output is comparable to the stopband attenuation of the prototype filter. In other words, the only error at the output of the analysis/synthesis system is the aliasing error which is at the level of stopband attenuation. Using this approach, it is possible to design a pseudo-QMF bank where the stopband attenuation of the analysis (and thus synthesis) filters is on the order of /spl minus/100 dB. Moreover, the resulting reconstruction error is also on the order of /spl minus/100 dB. Several examples are included. >
A quantitative determination of the damping behavior of acrylic-based interpenetrating polymer networks

Abstract The damping function, D.F., as derived from the area under the linearE″— temperature curve, expresses the amount of mechanical energy converted to heat per unit volume of material. Sometimes characteristics of the damping behavior of homopolymers and IPN's are more apparent in the linear E″—temperature plot, such as glass transitions and secondary transitions. Decrosslinking and/or annealing the IPN's have no effect on the D.F.'s, although these treatments significantly modify the shape of the E″—temperature curves as a result of molecular and phase rearrangements. Thus, to a first approximation, the area expressed by D.F. is a polymer chain characteristic, depending on the chain structure itself but not on crosslinking and/or annealing.
Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry

A variety of genomic and proteomic tools have been used to study cancer metabolism and metabolomics in order to understand how cancer cells survive in their environment. Throughout the past decade, mass spectrometry has been routinely used for large-scale protein identification of complex biological mixtures. In this review, we discuss some recent developments in cancer metabolism by proteomic analysis using mass spectrometric techniques, focusing on pyruvate kinase, L-lactate dehydrogenase, Warburg effect, glutamine metabolism and oxidative stress.
Abstract 187: Prevention of Circulating Progenitor Surge After Vascular Injury Effectively Reduces Restenosis

Background: Restenosis is an aberrant healing response that leads to failure of half of all vascular interventions and circulating progenitor cells have been implicated in restenotic pathology. Based on our previous findings of a surge specific to macrovascular injury, we hypothesized that a surge among progenitors and vascular injury signaling would be evident in the murine model and that an approach to prevent this surge would reduce restenosis. Methods: C57BL6 mice underwent injury of the femoral artery following either a depleting antibody to the progenitor marker sca-1 or a control antibody (n=8 per group). A third group had a non-vascular surgery (n=5). Antibody was administered pre-op and then until day 9. Blood and bone marrow were collected on days 1, 3, and 9 and analyzed by flow cytometry for progenitor markers CD34 and c-kit. Plasma was analyzed for the vascular injury signal, stromal cell-derived factor 1/CXCL12 (sdf1alpha). Vessel explants were imaged with lectin microscopy. Finally, animals treated with either sca-1 depleting antibody (n=4) or an isotype control (n=3) underwent vessel explant at 28 days and a lumen ratio was calculated. Results: Microscopy confirmed injury of endothelial monolayer and serologically, wire injury increased sdf1alpha by over 3 fold. Injury of the femoral artery resulted in a surge of CD34+/c-kit+ progenitors by over 2.2 fold relative to non-operative controls with a peak on day 1. Furthermore, this surge was prevented by treatment with a sca-1 antibody (P= 0.004). At 28 days, progenitor depletion increased the lumen from 20% among isotype treated controls to 79% among animals treated with direct progenitor depletion (P=0.04). Conclusions: It has not been previously demonstrated whether changes among progenitor cells impact restenotic pathology. Our findings suggest that a surge occurs in both a key vascular injury cytokine and among circulating progenitor cells after macrovascular injury. We have further demonstrated the efficacy of a depleting sca-1 antibody to mitigate progenitor surge and most importantly to reduce restenosis in a significant fashion. Future studies of strategies to block circulating progenitor cells may provide new therapies for this prevalent life and limb threatening disease.
Eleven years of runoff and phosphorus losses from two fields with and without manure application, Iowa, USA

Monitoring runoff at field edges can show how cropping systems and conservation practices affect runoff hydrology and water quality. Multi-year records are needed to characterize these effects, because of the variable, ephemeral nature of rainfall-runoff events. This study compared runoff and phosphorus (P) losses from two fields in central Iowa from 2000 through 2010. Both fields were managed in the same three-year, corn (Zea mays L.)–corn–soybean (Glycine max (L.) Merr.) rotation, but one field received applications of swine manure for each year of corn. Results comprised 116 events at the manured site and 94 events at the non-manured site, with 74 events common to both locations. Rainfall-runoff relationships for the two fields were similar; annual runoff averaged 54mm from the non-manured field and 47mm from the manured field. Large storms (>60mm rainfall) comprised about 10% of the runoff events in both watersheds, producing 12–16% of the total P loads. Moderate storms (30–60mm rainfall) generated most (65–70%) of the P load from both watersheds. Losses of P averaged 1.8kg Pha−1year−1 from the manured watershed and 1.05kgPha−1year−1 from the non-manured watershed. Relationships between runoff-volumes and P-loads differed between the two watersheds (p<0.05). Results highlight the challenge of maintaining adequate soil P levels while minimizing runoff P losses under a corn–soybean rotation, but indicate conservation practices that can limit runoff from storms of 30–60mm of rainfall can help producers meet that challenge.
Foliar ‘flags’ for avian frugivores: signal or serendipity?

We test and discuss two hypotheses relating autumn leaf-color to fruit color (Kerner, 1895) and to potential avian consumption (Stiles, 1982), using data from east-central Illinois. Kerner proposed that certain color combinations of fruit and background (foliage or branches) are particularly conspicuous and common and that in deciduousleaved plants they tend to occur in a certain seasonal order. We found no evidence to support this proposition for the eastern deciduous forest (and its edges) in our area. Stiles proposed that early autumn leaf-color might be well-developed in species with inconspicuous fruiting displays, in species with oily fruits, and in fruit-bearing individuals more than barren ones. None of these predictions was supported by our data. Fruit removal rates on experimentally ‘flagged’ individuals were no higher than on controls in any of the three species examined. In addition, many plants without food rewards for frugivores have colorful crowns in early fall and many fruit crops remain until late fall. The evidence for ‘foliar flags’ and their general use by foraging frugivores in our area is poor. The phenological and experimental data are discussed with respect to avian use of multiple clues for locating fruit crops, what is known (or not known) about avian color vision, seed dispersal by nonavian consumers, spatial and temporal variability in avian consumption of fruits, the quality of seed dispersal, bicolored fruiting displays, and the need to examine alternate hypotheses.
Onset for Superfluid Flow in He 4 Films on a Variety of Substrates

The onset of superfluid flow in ${\mathrm{He}}^{4}$ films was measured between 1.37 and 2.13 K on substrates of NaF, Ca${\mathrm{F}}_{2}$, Si${\mathrm{O}}_{2}$, Si, and Grafoil. Values of the Van der Waals constant of 19, 26, and 65 K were obtained for NaF, Si${\mathrm{O}}_{2}$, and Grafoil, respectively. In addition, a precise measurement of the critical thickness of the liquid-helium film was obtained, taking into account a small correction for the influence of the substrate.
Retail Sales of Eggs Priced by the Dozen and Pound—A Controlled Experiment

Abstract In a matched-lot controlled experiment, eggs priced by the pound outsold those priced by the dozen. Consumers were given the choice of buying eggs priced by the dozen or by the pound; the egg lots were displayed side by side on a shelf. Each dozen carton sold by the pound had a label showing net weight in pounds (to two decimal places), selling price per pound, and total price per dozen. An electronic scale was used for weighing, pricing, and labeling. Eggs were priced at 46 cents a pound, comparable to 25.5 ounce-per-dozen large eggs selling for 73 cents a dozen. Medium eggs were 68 cents, and small eggs 55 cents a dozen. Results were based on a one-month test (October, 1974) in which 19,562 dozen cartons of eggs were purchased. The test market was the Main Commissary, a large supermarket, at Fort Riley, Kansas. Sixty-three percent of the consumers buying eggs during the test purchased eggs priced by the pound.
A Four-Component Heterometallic Cu-Pt Quadrilateral via Self-Sorting

Herein we combine the subcomponent self-assembly and integrative self-sorting techniques with the well-established platinum(II)-pyridine coordination-driven self-assembly to report the quantitative synthesis and spectroscopic characterization of a heterometallic CuI -PtII quadrilateral QL that is formed from a total of twelve molecular components from four unique species, including 5-(pyridin-4-ylethynyl)picolinaldehyde (1), p-toluidine (2), [Cu(CH3 CN4 ](PF6 ) (3), and cis-Pt(PEt3 )2 (OTf)2 (4), in a 4:4:2:2 ratio. Despite the many different entities potentially forming from these four precursor units, the clean formation of QL is mainly guided by the different coordination preferences of the metal ions 3 and 4, and the design criteria inherent in compounds 1 and 2.
A region filling algorithm based on optimal neighborhood relativity

In order to improve the efficiency of recognition and filling for the region of interest,a region filling algorithm based on optimal neighborhood is presented.The temporary label of the object pixels is firstly determined by the neighborhood in the prior judgment order,which significantly accelerates the scan speed.Then a one-dimension array is used to store the equivalent relationship of the temporary label and final label,and sets are utilized to record the equivalent relationship among the temporary labels.Finally,set operations merge all temporary labels representing the same connected component with a final label.Experimental results show this optimized algorithm can effectively and stably fill connected domains with complex shapes.
Early Definitions of Meaning

Ullmann’s statement could apply to either the conceptual or the operational approach to definition. Definitions, or hypotheses, can be heuristic on a conceptual or experimental level. The early definitions of meaning were conceptual rather than operational, and tended to focus upon the content of experience. They ranged from the notion of ideas and images to elaborations that added such concepts as context, relationship, purpose or direction, and reference points within the individual rather than the object. The twentieth century was well under way before anyone proposed that meaning might be thought of in terms of conceptual organization or process, rather than in the more static descriptive way. Even the somewhat more dynamic definitions involving relationships between and among parts and wholes were more structurally or descriptively slanted than process oriented. That the definition of meaning might encompass action or behavior was never suggested until behavioristic psychology threw out meaning because it had become unnecessary as an explanatory or even descriptive concept.
Optical Design and Sampling Methods for the Measurement of Vibrational Circular Dichroism with a Nicolet Magna FT-IR Spectrometer

A modified design for a Fourier-transform vibrational circular dichroism (FT-VCD) spectrometer is presented. The FT-VCD instrument is based on a Nicolet Magna-IR 550 equipped with an external bench for the measurement of VCD spectra. VCD spectra of high signal quality were obtained with 20 minutes of collection time at 4 cm -1 resolution in the mid-infrared region by conventional sequential collection of rapid-scan VCD and transmission interferograms, the simultaneous collection of these rapid-scan interferograms and step-scan collection. Of these three methods the simultaneous rapid-scan exhibited the lowest levels of noise.
Repeated therapeutic lumbar punctures in cryptococcal meningitis – necessity and/or opportunity?

Purpose of reviewOverall, 50–70% of patients with cryptococcal meningitis have raised intracranial pressure (ICP). Multiple international treatment guidelines recommend repeated therapeutic lumbar punctures as adjunctive management. Here, we review the recent evidence for the role of repeated lumbar
Intraperitoneal radioimmunotherapy (RIT) for desmoplastic small round cell tumor (DSRCT): Initial results from a phase I trial.

3033 Background: DSRCT, a rare sarcoma of adolescents and young adults usually arising from the peritoneum, is lethal in >80% of patients despite aggressive multimodality therapy. Recurrences often...
In their shoes: co-creating value from deaf/hearing perspectives

Purpose This research investigates new innovative service models that provide opportunities for hearing and deaf individuals to switch roles within a co-created service encounter to allow for an enhanced perspective-taking experience. The purpose of this paper is to gain an in-depth understanding of deaf individuals’ experience working within such models using their preferred language, American sign language, to interact with a primarily hearing-majority customer base. Design/methodology/approach Data were collected for two studies through qualitative depth-interviews with both the deaf service employees and the hearing-majority customers from a North American restaurant founded on this innovative service model. Findings Results of these studies yield new insights into understanding the value generated for both the minority and majority populations within this co-creation platform. Notably, the deaf employees primarily recognize the transformative value derived from this service experience, whereas the hearing customers note the missing habitual value elements to which they are accustomed in traditional service encounters that inhibit repatronage intentions. Originality/value This is the first study to investigate the interpersonal service experience of deaf and hearing individuals within these emerging service models. Further, this research represents an initial attempt to explore a co-creative service experience between two different cultures, the deaf-minority and hearing-majority populations, with differing levels of ability.
Transplantation related toxicity and mortality in older autologous hematopoietic cell transplantation recipients.

With advances in supportive care, autologous hematopoietic cell transplant (AHCT) is increasingly being performed for patients older than 60 years. We analyzed patients receiving an AHCT for multiple myeloma or lymphoma in a contemporary cohort (2010-2012), with consistent treatment and supportive care and compared outcomes [CTCAE grade 3-5 toxicities, nonrelapse mortality (NRM) and overall-survival (OS)] of younger (40-59 years, n = 77) versus older (≥60 years, n = 67) recipients. The proportion of patients with neutropenic infections was higher in the older group (64% vs. 44%; P = 0.02). The proportion of patients with any grade 3-5 toxicity was also higher in the older group (84% vs. 67%, P = 0.03). In multivariate analysis, older age was significantly associated with higher odds (OR: 2.57, 95% CI:1.09-6.05) of grade 3-5 toxicity. The NRM was 3% (older) vs. 0% (younger) at 1 year. The probability of OS at 2 years was lower in the older group (76% vs. 90%, P = 0.04). Though AHCT can be performed safely in older recipients, the higher toxicity and slightly higher NRM in this population needs attention. Studies focusing on risk-stratification in older patients would further help predict toxicity. Further studies addressing enhanced supportive care needs for older patients who are most likely to benefit are indicated.
The Growing Problem of Horizontal Shareholding

Horizontal shareholding exists when significant shareholders have stock in horizontal competitors. (It is often imprecisely called "common shareholding," but that term can also apply when shareholders own stock in two noncompeting corporations. It differs from "cross-shareholding," which describes situations when firms own stock in each other, though cross-shareholding is effectively a special case of horizontal shareholding when the firms are competitors.) This Article presents new evidence confirming that horizontal shareholding has anticompetitive effects harmful to our economy and showing that the problem is only getting worse. It also rebuts various critiques of my proposal that high levels of horizontal shareholding in concentrated markets should be investigated and subject to antitrust enforcement when they are shown to have anticompetitive effects.
Dialogues at the Edge

William James lived at the boundaries and did his best work there. In 1890, James published his magnum opus, The Principles of Psychology, a foundational work in which he makes clear distinctions about the kinds of assumptions each discipline takes for granted and then subjects these assumptions to critical examination. For many years, this was a widely used text that uniquely blended his personal reflections with his ideas on physiology, philosophy, and psychology. Throughout the book and his career, James extravagantly crossed the boundaries of multiple disciplines. This volume is comprised of a series of in-depth interviews with ten North American scholars and clinical practitioners who have similarly spent their lengthy careers working at the interdisciplinary edges of mainstream psychological discourse.
A rules-based algorithm to identify patients who would benefit from re-addressing advance care planning.

4Background: Advance care planning (ACP) should be initiated early and readdressed often for cancer patients. We hypothesize that a rules-based algorithm can predict decreased overall survival, and can be used to target patients who would benefit from readdressing ACP. Methods: We performed a retrospective analysis of 219 patients receiving palliative chemotherapy with leukemia, cholangiocarcinoma, esophageal, gastric, pancreatic, lung or urothelial cancer at the University of Chicago Medicine. Patients were included if they had an index outpatient oncology visit from April 1, 2015 through June 30, 2015. We examined a three-month window from the index visit for a “high-risk event,” defined as: 1. change in chemotherapy 2. emergency department visit 3. hospitalization. Patients were followed from index visit until date of death or last clinical encounter as of January 31, 2017. Each “high-risk event” was treated as a time-varying covariate in a Cox proportional hazards regression model to calculate a hazar...
The relationship between personality disorder traits, emotional intelligence, and college adjustment

Objective The current study examined the relationship between emotional intelligence, personality disorder traits, and college adjustment. Method A sample of 246 first-semester, first-time freshmen (73.6% female, age mean = 18.7, standard deviation = 2.0) at a large university in the Eastern United States completed the Trait Emotional Intelligence Questionnaire (Petrides, 2009), the Schedule for Nonadaptive and Adaptive Personality-2 (Clark, Simms, Wu, & Casillas, 2014), and the Student Adaptation to College Questionnaire (Baker & Siryk, 1998). Results As predicted, personality disorder symptoms and emotional intelligence were generally related, and both were related to adjustment. Unique patterns of association between traits reflecting personality disorder clusters and emotional intelligence deficits also emerged. Contrary to expectation, however, emotional intelligence did not moderate the relationship between personality disorders and adjustment. Conclusion The results suggest an alternative model implicating emotional intelligence as a mediator of the relationship between personality difficulties and college adjustment.
Draft Genome Sequences of Nine New Carnobacterium maltaromaticum Strains Isolated from Diseased Sharks.

ABSTRACT Here, we report the draft genome sequences of 9 strains of Carnobacterium maltaromaticum (SK_LD1 to SK_LD3 and SK_AV1 to SK_AV6), a member of the Carnobacteriaceae family (phylum Firmicutes). These strains were isolated from the brain and the inner ear of three diseased thresher sharks and two diseased salmon sharks. The genome assembly resulted in an average of 3,306,205.9 ± 29,143.9 bp and 3,085 ± 32.67 coding DNA sequences (CDS).
TAL Effector Nuclease (TALEN) Engineering

TALENs, fusion proteins of DNA binding domains of TAL (transcription activator-like) effectors and the DNA cleavage domains of endonuclease FokI, have emerged as genetic tools for targeted gene modification, holding great potential for basic and applied research, even for gene therapy. Here we present a simple and efficient approach to custom-engineering TALEN genes with four basic TAL repeats and their DNA recognition cipher. The "modular assembly" method also involves the "Golden Gate" cloning strategy, using 53 ready-to-use plasmids in just two rounds of restriction and ligation to assemble TALENs with up to 24 repeat units that recognize up to 24 bp of target DNA.
A General Inequality

In the last lecture we remarked that some a priori inequality is required in elasticity in order to get the results of the classical infinitesimal theory, generally accepted as just for small deformations. On the other hand, we cannot follow blindly the lead of pure analysis and impose conditions strong enough to yield unqualified uniqueness of solution to the boundary-value problem of place and traction, since such uniqueness in large strain would be just as inappropriate as failure of that uniqueness in small. In any case, this caution is presently an empty one, since the general differential equations of elasticity lie outside the domain for which analysts have constructed a theory.
Casting light on focal adhesions.

Oncogenic transformation by v-Src is associated with dramatic alterations in cell morphology, actin organization and anchorage-dependence. These changes correlate with tyrosine phosphorylation of multiple proteins that associate with cytoskeletal structures known as focal adhesions (FA)  membrane-associated sites where clustered integrin receptors couple extracellular matrix (ECM) proteins to intracellular cytoskeletal proteins and actin stress fibers (Fig. 1). Although the structural components of FAs are well-defined, the specific roles of individual Src substrates in integrin-mediated cytoskeletal rearrangements or Src-mediated transformation remain elusive. On page 361 of this issue, Hisamaru Hirai and coworkers demonstrate that the FA-associated protein p130Cas (or Cas, which is encoded by Crkas), is essential for myofibril organization in cardiac muscle, actin organization of stress fibers in cultured fibroblasts, and Src-induced morphological transformation and anchorage-independence. These studies implicate Cas in the regulation of actin organization and highlight the structural and functional similarities of FAs and muscle Z discs (to which actin fibers attach). In addition, they suggest that the role of Cas in Src transformation may involve actin organization.
Metabolic Control Analysis Shows How Aneuploidy Causes Cancer

Over loo years ago aneuploidy, a numerical abnormality of chromosomes, was proposed as the cause of cancer (von Hansemann, 1890; Boveri, 1914). Since about 1970, the aneuploidy hypothesis has lost support over the years because it was unable to provide a specific mechanism for how the characteristic phenotypes of cancer cells could be generated without gene mutation. However, it is becoming increasingly apparent that the prevailing gene-mutation hypothesis of cancer is incapable of explaining the complexity and diversity of cancer-specific phenotypes, including dedifferentiation, invasiveness, metastasis, abnormal morphology and metabolism, genetic instability, and progression to malignancy (Duesberg & Schwartz, 1992). The failure of the gene-mutation hypothesis to explain cancer led us to re-examine the aneuploidy hypothesis in order to investigate how cancer could be caused without gene mutations (Li et al., 1997; Duesberg et al., 1998; Rasnick & Duesberg, 1999; see also Chapter 9 in this book).
Workers' compensation insurer risk control systems: Opportunities for public health collaborations.

Abstract Introduction Workers' compensation (WC) insurers offer services and programs for prospective client selection and insured client risk control (RC) purposes. Toward these aims, insurers collect employer data that may include information on types of hazards present in the workplace, safety and health programs and controls in place to prevent injury/illness, and return-to-work programs to reduce injury/illness severity. Despite the potential impact of RC systems on workplace safety and health and the use of RC data in guiding prevention efforts, few research studies on the types of RC services provided to employers or the RC data collected have been published in the peer-reviewed literature. Methods Researchers conducted voluntary interviews with nine private and state-fund WC insurers to collect qualitative information on RC data and systems. Results Insurers provided information describing their RC data, tools, and practices. Unique practices as well as similarities including those related to RC services, policyholder goals, and databases were identified. Conclusions Insurers collect and store extensive RC data, which have utility for public health research for improving workplace safety and health. Practical applications Increased public health understanding of RC data and systems and an identification of key collaboration opportunities between insurers and researchers will facilitate increased use of RC data for public health purposes.
Pathologic Features and Clinical Implications of Breast Cancer With HER2 Intratumoral Genetic Heterogeneity.

Objectives To review breast cancer with human epidermal growth factor receptor 2 (HER2) genetic heterogeneity (GH), with a focus on clinician interpretation of the results and subsequent management. Methods We retrospectively searched all consecutive invasive breast cancers that underwent HER2 fluorescent in situ hybridization testing and identified cases with HER2 GH. Results Eleven (0.4%) cases of primary breast tumors with reported HER2 GH were identified over 76 months. HER2-positive tumor cells comprised a mean ± SD of 20% ± 15% of the overall tumor population (range, 5%-50%) and exhibited high levels of amplification (HER2/CEP17 = 5.4 ± 2.9). Three cases had morphologic heterogeneity. Of the four patients who completed neoadjuvant chemotherapy, two had trastuzumab; all showed a partial pathologic response. We identified two cases in which there appeared to be clinical misinterpretation of the HER2 results. Conclusions HER2 GH is an infrequent event, may contain morphologic heterogeneity, could infer incomplete response to neoadjuvant therapy, and requires adequate communication with treating clinicians.
Characterizing Tilt Effects on Wind Plants

Tilting the nacelle of a wind turbine modifies entrainment into the wind plant and impacts total efficiency. Wakes are deflected vertically by tilt and in the case of large angles can disrupt entertainment from the undisturbed flow or dissipate on the ground. The effect of nacelle tilt on wake behavior is investigated in a series of wind tunnel experiments for the first time. Scale model turbines with a hub height and a diameter of 12 cm are arranged in a Cartesian array composed of four rows of three turbines each. The tilt angle was varied in the third turbine row from −15° to 15° in chosen 5° increments. Stereo particle image velocimetry measurements of the instantaneous velocity field were recorded at four locations for each angle. Tilted wakes are described in terms of the average streamwise velocity, vertical velocity, and Reynolds stresses. Mean kinetic energy quantities are presented, and conditional sampling is employed to quantify the importance of sweep to ejection events in vertical momentum transfer. Additionally, the effect of nacelle tilt on net power production is presented and compared to existing models. Numerical simulations accurately predict losses in net efficiency for positive angles but diverge for negative tilt angles. The results demonstrate that the tilt angle influences wake magnitude, displacement, and recovery. Positive angles deflect wakes above the wind plant, while negative angles encourage entrainment into the wind plant and exhibit rapid recovery.
Review of Kuxlejal Politics. Indigenous Autonomy, Race, and Decolonizing Research in Zapatista communities

Kuxlejal Politics. Indigenous Autonomy, Race, and Decolonizing Research in Zapatista communities, by Mariana Mora. University of Texas, 2017.
P-032 Post procedural low dose heparin drip reduces thrombotic events following pipeline embolization, without increasing hemorrhagic complications

Purpose Pipeline embolization devices (PEDs) are associated with inherent thrombotic complications as well as potentially catastrophic spontaneous intraparenchymal hemorrhage. Anti-platelet and anticoagulation therapy must be optimized to reduce thrombotic complications without increasing the incidence of hemorrhage. Post-procedural low dose heparin drip is a prophylactic measure to reduce ischemic stroke risk, with no published data to date reporting efficacy and complications. Here we report the thrombotic and hemorrhagic complication rates of patients receiving post-operative low dose heparin drip, and we compare our results to the published literature rates of patients not receiving such prophylaxis. Materials and methods We completed a retrospective review of patients who had intracranial aneurysms treated with the Pipeline Embolization Device at Westchester Medical Center. A total of 73 individuals received post-operative low dose heparin for an average of 18 hours. Thrombotic and hemorrhagic complications were identified and reported. These rates were compared to the published literature rates of individuals not receiving post-operative heparin. Additional variables included PTT range, type of heparin protocol used (weight based vs physician controlled), total time of heparinization, heparin dose, and number of PEDs deployed. Results 0% (0/73) patients developed thrombotic complications in the post-operative period. The reported literature rate of symptomatic thrombotic events is 6.6%. Post-operative heparin reduced symptomatic thrombotic complications following PED placement (p=0.0125). 2.7% (2/73) patients developed intraparenchymal hemorrhage resulting in neurological deficit, compared to a published rate of hemorrhagic complications approximating 3%. Conclusions Post-procedural low dose heparin prophylaxis reduces thrombotic complications in the post-operative period, without increasing hemorrhagic complications. Disclosures I. Rybkin: None. J. Cooper: None. G. Kaur: None. F. Al-Mufti: None. C. Gandhi: None. J. Santarelli: None.