cssi/SciSciGPT-SciSciNet huggingface dataset:
Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Here we provide evidence that RBBP4 modulates temozolomide (TMZ) sensitivity through coordinate regulation of two key DNA repair genes critical for recovery from TMZ-induced DNA damage: methylguanine-DNA-methyltransferase (MGMT) and RAD51. Disruption of RBBP4 enhanced TMZ sensitivity, induced synthetic lethality to PARP inhibition, and increased DNA damage signaling in response to TMZ. Moreover, RBBP4 silencing enhanced TMZ-induced H2AX phosphorylation and apoptosis in GBM cells. Intriguingly, RBBP4 knockdown suppressed the expression of MGMT, RAD51, and other genes in association with decreased promoter H3K9 acetylation (H3K9Ac) and increased H3K9 tri-methylation (H3K9me3). Consistent with these data, RBBP4 interacts with CBP/p300 to form a chromatin-modifying complex that binds within the promoter of MGMT, RAD51, and perhaps other genes. Globally, RBBP4 positively and negatively regulates genes involved in critical cellular functions including tumorigenesis. The RBBP4/CBP/p300 complex may provide an interesting target for developing therapy-sensitizing strategies for GBM and other tumors.
The lawyer terrorist and his comrades.

Horst Mahler, a young lawyer who had fled to West Berlin, was the cofounder of the Red Army Faction. While imprisoned for committing acts of terror, he and other leading terrorists directed raids and kidnappings against the "system." His published interviews and "cell circulars" provide important insights into the multicausal factors in the making of a terrorist: (1) Apprehensions over the profound progress of scientific and technological progress exploited by the capitalist system. (2) Blame directed toward the father's generation for the horrors of the Hitler system and complicity with the expansionistic United States. (3) Inability to identify with an adequate father figure which led to anti-authoritarian stance and overcompensation when the terrorists exercised their own ruthless authority. Enclosure in the underground reinforced hostility. The psychological mechanisms caused by withdrawal from society fostered commission of dehumanized acts.
Fractionation studies of copper in erythrocytes from normal, sickle cell anemia, and hemoglobin C disease

SummaryQuantitative copper determinations of erythrocyte fractions obtained by ultracentrifugation of erythrocyte homogenates from 105- persons were made by atomic absorption spectrophotometry. Elevated copper levels were demonstrated in the particulate fraction of erythrocytes of 16 patients with sickle cell anemia (Hb SS), 30 patients with sickle cell trait (Hb AS), 14 patients with hemoglobin C trait (Hb AC), and 5 patients with hemoglobin SC, as compared to similar fractions from 40 normal persons (Hb AA). Erythrocytes from sickle cell anemia patients contained sedimentable copper levels approximately twice that of normal controls. The sedimentable copper values from sickle cell trait were 1.5 times that of normal cells. The significance of these findings is discussed.
Charge transport in TiO 2 / M E H − P P V polymer photovoltaics

We study the effect of polymer thickness, hole mobility, and morphology on the device properties of polymer-based photovoltaics consisting of MEH-PPV as the optically active layer, ${\mathrm{TiO}}_{2}$ as the exciton dissociation surface, and ITO and Au electrodes. We demonstrate that the conversion efficiency in these polymer-based photovoltaics is primarily limited by the short exciton diffusion length combined with a low carrier mobility. For MEH-PPV devices with optimal device geometry, we achieve quantum efficiencies of 6% at the maximum absorption of the polymer, open circuit voltages of 1.1 V, current densities of 0.4 ${\mathrm{m}\mathrm{A}/\mathrm{c}\mathrm{m}}^{2}$ and rectification ratios greater than ${10}^{5}$ under 100 ${\mathrm{m}\mathrm{W}/\mathrm{c}\mathrm{m}}^{2}$ white light illumination. In addition, we achieve fill factors up to 42% at high light intensities and as high as 69% at low light intensities. We conclude by presenting a model that describes charge transport in ${\mathrm{s}\mathrm{o}\mathrm{l}\mathrm{i}\mathrm{d}\ensuremath{-}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{t}\mathrm{e}\phantom{\rule{0ex}{0ex}}\mathrm{p}\mathrm{o}\mathrm{l}\mathrm{y}\mathrm{m}\mathrm{e}\mathrm{r}/\mathrm{T}\mathrm{i}\mathrm{O}}_{2}$-based photovoltaics and suggest methods for improving energy conversion efficiencies in polymer-based photovoltaics.
Partial immunologic reconstitution of a patient with acquired agammaglobulinemia: a transient phenomenon accompanying therapeutic plasmapheresis

A patient with acquired agammaglobulinemia was treated with plasmapheresis. The rationale for this procedure was based on the presence of a cytotoxic autoantibody with specificity for helper (TH2-) T lymphocytes. Plasmapheresis reduced the autoantibody concentration to undetectable levels, which resulted in an increase number of helper T cells. These T cells provided normal in vitro helper activity. Plasmapheresis did not correct a concomitant suppressor T-cell defect, and the clinical remission ended during the fifth month of exchange therapy.
Functional Properties of Pea Protein Isolate Subjected to Phenol Removal and Alkali Treatment

Pea protein isolate(PPI) was prepared from defatted pea flour by sequential treatment with methanol followed by acetone and then subjected to alkali treatment. The effects of phenol removal(with methanol/acetone extraction) and alkali treatment at pH 12 on the particle size, solubility and emulsifying properties of PPI were investigated. The amino acid profile and protein subunit changes were examined to elucidate the relationship between protein structure and functionality. Gentisic acid, hydroxybenzoic acid, coumaric acid and ferulic acid were identified using HPLC with phenolic compound standards. Decreased protein particle size and improved solubility and emulsifying properties were observed in PPI after both treatments. These processes also selectively removed some polypetides rich in arginine and cysteine. However, alkali treatment was more effective to improve protein functionality than phenol removal.
Prediction of Nanoparticle and Colloid Attachment on Unfavorable Mineral Surfaces Using Representative Discrete Heterogeneity.

Despite several decades of research there currently exists no mechanistic theory to predict colloid attachment in porous media under environmental conditions where colloid–collector repulsion exists (unfavorable conditions for attachment). It has long been inferred that nano- to microscale surface heterogeneity (herein called discrete heterogeneity) drives colloid attachment under unfavorable conditions. Incorporating discrete heterogeneity into colloid–collector interaction calculations in particle trajectory simulations predicts colloid attachment under unfavorable conditions. As yet, discrete heterogeneity cannot be independently measured by spectroscopic or other approaches in ways directly relevant to colloid–surface interaction. This, combined with the fact that a given discrete heterogeneity representation will interact differently with differently sized colloids as well as different ionic strengths for a given sized colloid, suggests a strategy to back out representative discrete heterogeneity by ...
A Bibliography of the Noema

The following bibliography includes not only articles that deal explicitly with the concept of the noema but articles that address the noema within the more general framework of Husserl’s thought on intentionality. The primary Husserlian text is Ideas I (1913), although many commentators appeal to passages in Logical Investigations (1900-01) and Cartesian Meditations (1931).
Historical change in the report of daytime fatigue

Population-based data suggesting that contemporary society does not value sleep are difficult to obtain. In this report, historical change in item endorsements relevant for disturbed sleep and daytime fatigue from the Minnesota Multiphasic Personality Inventory (MMPI) generated from normative, upper Midwestern adult populations was analyzed. Response rates from the 1930s and 1980 were compared. The data indicated that, relative to individuals in the post-Great Depression/pre-World War II era, contemporary men were more likely to report fatigue and tiredness, although they were no more likely to report disturbed nocturnal sleep. The results are compatible with the voluntary curtailment of sleep typical in modern society described in the report of the National Commission on Sleep Disorders Research.
Comparative analysis of techniques to prevent laparoscopic fogging

Purpose: To evaluate the efficiency and efficacy of two common and commercially available methods to resolve lens fogging: a Fluid Warming System (O.R. Solutions, Chantilly, VA) and the Clearify Vi...
New species of Tobantilla Casal, 1965 and a new genus and species, Gogoltilla chichikovi gen. et sp. nov., from Argentina (Hymenoptera: Mutillidae)

Seven new species of Tobantilla Casal are described: T. aleatrix Williams, Brothers & Pitts, sp. nov. (Argentina), T. andrikos Williams, Brothers & Pitts, sp. nov. (Colombia), T. drosos Williams, Brothers & Pitts, sp. nov. (Argentina), T. ephemeros Williams, Brothers & Pitts, sp. nov. (Argentina, Uruguay), T. kolasma Williams, Brothers & Pitts, sp. nov. (Venezuela), T. krima Williams, Brothers & Pitts, sp. nov. (Colombia), and T. xouthos Williams, Brothers & Pitts, sp. nov. (Venezuela). Four of these species represent the first males described in Tobantilla. Tobantilla frigidula (Cresson), comb. nov. and the two original members of Tobantilla, T. charrasca Casal and T. montonera Casal, are redescribed. A new genus that is apparently closely related to Pseudomethoca Ashmead, but closely resembles Tobantilla, is described: Gogoltilla Williams, Brothers & Pitts, gen. nov., based on both sexes of Gogoltilla chichikovi Williams, Brothers & Pitts, sp. nov. (Argentina).
Magnetic and Electronic Phase Transitions

Magnetism in materials originates with electron spins and their alignments. Groups of spins develop patterns and structures at low temperatures through interactions with each other. With temperature, pressure, and magnetic field, these spatial patterns of electron spins are altered, and several trends can be understood by thermodynamic considerations. This chapter describes how magnetic structures change with temperature. The emphasis is on magnetic moments localized to individual atoms, as may arise from unpaired 3 d electrons at an iron atom, for example. The strong intra atomic exchange interaction gives an atom a robust magnetic moment, but the magnetic moments at adjacent iron atoms interact through inter atomic exchange interactions. Interatomic exchange interactions are often weaker, having energies comparable to thermal energies. Interatomic exchange is analogous to chemical bonding between pairs of atoms in a binary alloy that develops chemical order. The critical temperature of chemical ordering T c corresponds to the Curie temperature for a magnetic transition T C , and short-range chemical order above the T c finds an analog in the Curie–Weiss law for paramagnetic susceptibility above T C . For chemical ordering the atom species are discrete types, whereas magnetic moments can vary in strength and direction as vector quantities. This extra freedom allows for diverse magnetic structures, including antiferromagnetism, ferrimagnetism, frustrated structures, and spin glasses.
Iterated reweighted rank-based estimates for GEE models

Repeated measurement designs occur in many areas of statistical research. In 1986, Liang and Zeger offered an elegant analysis of these problems based on a set of generalized estimating equations (GEEs) for regression parameters, that specify only the relationship between the marginal mean of the response variable and covariates. Their solution is based on iterated reweighted least squares fitting. In this paper, we propose a rank-based fitting procedure that only involves substituting a norm based on a score function for the Euclidean norm used by Liang and Zeger. Our subsequent fitting, while also an iterated reweighted least squares solution to GEEs, is robust to outliers in response space and the weights can easily be adapted for robustness in factor space. As with the fitting of Liang and Zeger, our rank-based fitting utilizes a working covariance matrix. We prove that our estimators of the regression coefficients are asymptotically normal. The results of a simulation study show that the our proposed estimators are empirically efficient and valid. We illustrate our analysis on a real data set drawn from a hierarchical (three-way nested) design.
Magnesium and Metabolic Syndrome: The Role of Magnesium in Health and Disease

Metabolic syndrome is a constellation of conditions associated with elevated risk of diabetes and cardiovascular disease. Magnesium, the fourth most abundant cation in the human body and required in over 300 enzymatic reactions, has been shown in experimental, observational, and clinical studies to improve various risk factors of metabolic syndrome. This chapter is an overview of metabolic syndrome, magnesium, and the evidence supporting the role of magnesium in ameliorating conditions associated with the syndrome in humans.
A MaximumLpDistance Problem

This paper deals with the problem of finding a point within a convex or nonconvex planar region, which is farthest from a given point. Equivalently, given a facility serving a geographical region, a point of this region is sought which receives the least amount of service, assuming that the amount of service received decreases with distance from the facility. Applications of this problem can be found in the military, transportation, telecommunications, and public safety services. In this study the generalizedLpnorm is considered as the distance metric. For this nonlinear and nonconvex problem, properties of the optimal solution are established. Based on these properties a solution algorithm is developed, consisting of (a) thesubdivision procedurethat decomposes the boundary into manageable nonlinear segments, and (b) a branch and bound basedenveloping procedurewhich determines the optimal solution on a nonlinear segment. Using Karush–Kuhn–Tucker conditions, it is proved that the optimal solution in the special cases of the rectilinear and Tchebycheff metrics is among a set of four candidate points. For the Tchebycheff metric, a converse problem, the farthest point Vornoi diagram is defined and constructed. Appropriate examples illustrate all cases.
Parallels in Structural Chemistry between the Molecular and Metallic Realms Revealed by Complex Intermetallic Phases

ConspectusThe structural diversity of intermetallic phases poses a great challenge to chemical theory and materials design. In this Account, two examples are used to illustrate how a focus on the most complex of these structures (and their relationships to simpler ones) can reveal how chemical principles underlie structure for broad families of compounds. First, we show how experimental investigations into the Fe–Al–Si system, inspired by host–guest like features in the structure of Fe25Al78Si20, led to a theoretical approach to deriving isolobal analogies between molecular and intermetallic compounds and a more general electron counting rule. Specifically, the Fe8Al17.6Si7.4 compound obtained in these syntheses was traced to a fragmentation of the fluorite-type structure (as adopted by NiSi2), driven by the maintenance of 18-electron configurations on the transition metal centers.The desire to quickly generalize these conclusions to a broader range of phases motivated the formulation of the reversed appr...
Cruel Optimism in Sport Management: Fans, Affective Labor, and the Political Economy of Internships in the Sport Industry:

For university students in sport management programs, working in sports is often the end goal, and internships have become the most common curricular component for achieving this end. Sport managem...
A practical method to evaluate personalized injected patient dose for cardiac perfusion SPECT imaging: the polar map as a numerical observer

The diversity in the patient population necessitates a more refined dose reduction approach in cardiac perfusion imaging. We have recently formulated a strategy to better calculate individual and personalized injected doses using the body mass index. The purpose of this study is to present a practical method to evaluate the efficacy of personalizing injected dose employing the polar map methodology. Two hundred and fifty-two normally read patients were used to either determine the personalized dose or to test the dose reduction strategy. Fifty of the test patient studies were altered by inserting perfusion defects in the LV wall. The original or full dose as well as the personalizes dose data were reconstructed using OSEM (Ordered subsets expectation maximization) with attenuation, scatter and spatial resolution compensation. The ROC results show that the personalized dose strategy does not adversely affect the detection of perfusion defects.
Game Theoretical Approaches in Wireless Networks

In this chapter, we review game theoretical approaches in wireless networks, mainly the issues of power control, cooperation between mobile terminals, security, and radio channel access control.
On the Importance of Dimensionality in the Simulation of Dense Non-Aqueous Liquid Migration in the Subsurface

The simulation of dense non-aqueous phase liquid migration in the subsurface is computationally demanding. As a consequence it is common to reduce the dimensionality of the problem. Herein we investigate the impact of reducing the dimensionality of a DNAPL migration problem from three to two.
Assessing the Potential Effect of Cross-Hybridization on Oligonucleotide Microarrays

We introduce a computational method which estimates non-specific binding associated with hybridization signal intensities on the oligonucleotide-based Affymetrix GeneChip arrays. We consider a simplified linear hybridization model that should work well when the target DNA concentration is low or when the probe-target affinity is weak, and use the quadratic programming technique to estimate the parameters of this model (binding coefficients). We show that binding coefficients correlate with the degree of homology between the probe and target sequences. Detectable contribution into DNA binding was found to start from the matches of 7–8 nucleotides. The method suggested here may prove useful for the interpretation of hybridization results and for the assessment of true target concentrations in microarray experiments.
Hodgkin's disease of the prostate: a detailed case report.

AbstractMalignant lymphoma of the prostate is an unusual entity, and nonHodgkin’s lymphoma constitutes most reported cases. We report a well documented case of Hodgkin’s lymphoma, initially involving the gastrointestinal tract and spleen, which recurred in the prostate following initial remission with chemotherapy. Treatment with external beam radiotherapy resulted in a rapid complete response that has been sustained for 18 months.
Low Resolution Sampling for Joint Millimeter-Wave MIMO Communication-Radar

We propose the deployment of millimeter-wave MIMO for joint vehicular high speed communication and high resolution radar sensing. To cope with the significant hardware complexity, we consider the use of low resolution analog-to-digital converters (ADC) while maintaining a separate radio-frequency chain per antenna. The system performance is analyzed in terms of Cramer Rao lower bound and achievable data rate, and compared to the ideal case with infinite resolution ADCs. Additionally, we study the impact of quantization on the trade-off between these performance metrics. Numerical results demonstrate the potential of the concept to meet the challenging requirements of next-generation vehicles.
On a Combinatorial Framework for Fault Characterization

Covering arrays have been widely used to detect the presence of faults in large software and hardware systems. Indeed, finding failures that result from faulty interactions requires that all interactions that may cause faults be covered by a test case. However, finding the actual faults requires more, because the failures resulting from two potential sets of faults must not be the same. The combinatorial requirements on test suites to enable a tester to locate the faults are developed, and set in the context of similar combinatorial search questions. Test suites known as locating and detecting arrays to locate faults both in principle and in practice generalize covering arrays, thereby addressing combinatorial fault characterization. In common with covering arrays, these locating and detecting arrays scale logarithmically in size with the number of factors, but unlike covering arrays they support complete characterization of the interactions that underlie faults.
Empirical Study on High-Dimensional Variable Selection and Prediction Under Competing Risks

Competing risk analysis considers event times due to multiple causes, or of more than one event types. Commonly used regression models for such data include (1) cause-specific hazards model, which focuses on modeling one type of event while acknowledging other event types simultaneously; and (2) subdistribution hazards model, which links the covariate effects directly to the cumulative incidence function. Their use and in particular statistical properties in the presence of high-dimensional predictors are largely unexplored. We study the accuracy of prediction and variable selection of existing statistical learning methods under both models using extensive simulation experiments, including different approaches to choosing penalty parameters in each method.
Race/Ethnicity and 30-Day Readmission Rates in Medicare Beneficiaries With COPD.

BACKGROUND: COPD is now included in Medicare9s hospital readmission reduction program. Hospitals with excessive risk-adjusted 30-d readmission rates receive financial penalties. Race/ethnicity is not included in the risk-adjustment models. We examined whether race/ethnicity was independently associated with readmission after controlling for clinical factors and other demographic variables. METHODS: We used the 100% Medicare in-patient (Part A) files to identify patients hospitalized with COPD (MS-DRG codes 190, 191, 192) who were discharged between January 1, 2013, and September 13, 2014. The outcome measure was an unplanned readmission within 30 d of hospital discharge. We used generalized linear mixed models to test the independent effects of race/ethnicity on 30-d readmission. RESULTS: The sample included 298,706 Medicare beneficiaries hospitalized for COPD: 87% white, 8% African-American, and 5% Hispanic. Mean age was 77.7 ± 7.7 y. Overall, 17.3% of subjects experienced an unplanned readmission. Whites (17.4%) and African-Americans (17.7%) had significantly higher unadjusted rates than Hispanics, and Hispanics demonstrated the lowest readmission rate (16.3%). The minority groups generally displayed higher-risk clinical profiles. After controlling for those differences, the multivariable model suggested a benefit for both minority groups in terms of readmission risk. The adjusted readmission rates for whites, African-Americans, and Hispanics were 16.6%, 15.9%, and 14.6%, respectively. CONCLUSIONS: Racial/ethnic disparities in observed readmission rates may be largely explained by the more severe clinical profiles of minority populations. Controlling for known clinical risk factors effectively mediates the relationship between race/ethnicity and readmission.
Effect of exogenous progesterone administration on cigarette smoking-related symptomology in oral contraceptive users who smoke.

Abstract Cigarette smoking-related symptomatology (e.g., craving; SRS) is linked to relapse after a quit attempt. SRS varies by menstrual phase, possibly due to variations in sex hormones (e.g., progesterone), though much of the research to-date has relied on observations from the menstrual cycle acting as a proxy for hormone levels. The goal of this study was to examine the effect of exogenous progesterone on SRS during ad libitum smoking and following overnight abstinence. Oral contraceptive users who smoked completed two 9-day crossover testing periods (7 days of ad libitum smoking and 2 days following overnight abstinence) while taking double-blind active/placebo exogenous progesterone. Participants completed questionnaires to measure SRS. The effect of exogenous progesterone and endogenous hormones (progesterone, estradiol, and progesterone-to-estradiol [P/E2] ratio) on SRS was assessed with paired t-tests and linear mixed effect models. Participants (n = 53) were, on average, 24 years old and smoked 11 cigarettes per day. During ad libitum smoking, a doubling of the P/E2 ratio was associated with 0.09 points lower anticipated relief from negative affect (95% confidence interval [CI]: 0.03–0.15 points lower; p = 0.008) and 0.11 points lower psychological reward (95% CI: 0.03–0.18 points lower; p = 0.006). After correction for multiple testing, these associations were not statistically significant: anticipated relief from negative effect (p = 0.10) and psychological reward (p = 0.09). No other significant associations were observed. Although substantial previous literature indicates that progesterone influences SRS, exogenous progesterone administration did not alter SRS here. Additional research is needed to elucidate alternative mechanisms involved in menstrual phase effects on SRS.
Trends in nonoperative management of papillary thyroid microcarcinoma.

BACKGROUND In 2010, a Japanese trial of nonoperative management for papillary thyroid microcarcinomas (PTmC) was published. This study determines if the prevalence of nonoperative management in the United States has changed and if there are predictors of this approach. METHODS Patients treated for PTmC between 2004 and 2015 in the National Cancer Data Base were identified. Inclusion criteria were: classic or follicular variant papillary cancer histology, tumor size 1 to 10 mm, cN0 disease and no extrathyroidal extension or metastatic disease. Nonoperative management was assessed over time and compared between 2004-2010 and 2010-2015. Logistic regression identified factors associated with nonoperative management. RESULTS Of 65 381 PTmC patients, 344 (0.5%) were treated nonoperatively. The annual rate of nonoperative management was similar at 0.6% in 2004 to 0.4% in 2010 (P = .755) but increased to 0.9% in 2015 (P < .001). There was no difference in patient age, race, comorbidities, or reason for nonoperative management between the two periods. Academic centers managed more patients nonoperatively. Multivariable logistic regression suggests older age, facility type, location, Hispanic, Asian, and Native American ethnicity were associated with nonoperative management. CONCLUSION The vast majority of PTmC in the United States is treated with an operation. A small but significant increase in nonoperative management occurred between 2004-2010 and 2010-2015.
Graph Theory and IC Component Design Analysis

Graph analysis in large integrated circuit (IC) designs is an essential tool for verifying design logic and timing via dynamic timing analysis (DTA). IC designs resemble graphs with each logic gate as a vertex and the conductive connections between gates as edges. Using DTA digital statistical correlations, graph condensation, and graph partitioning, it is possible to identify high-entropy component centers and paths within an IC design. Identification of high-entropy component centers (HECC) enables focused DTA, effectively lowering the computational complexity of DTA on large integrated circuit graphs. In this paper, a devised methodology termed IC layout subgraph component center identification (CCI) is described. CCI lowers DTA computational complexity by condensing IC graphs into reduced subgraphs in which dominant logic functions are verified.
Market Access, Production Diversity, and Diet Diversity: Evidence From India:

Background:Recent literature, largely from Africa, shows mixed effects of own-production on diet diversity. However, the role of own-production, relative to markets, in influencing food consumption...
Neuropsychiatric comorbidities in hypothyroidism: A systematic review

Abstract Objectives Impairment of thyroid function is implicated in different neuropsychiatric manifestations. This systematic review article will examine and discuss (1) the biochemistry of thyroid hormones, including structure, synthesis, and homeostasis, (2) the neurophysiological role of the hypothalamic-pituitary-thyroid (HPT) axis in development and maintenance of a euthymic state, (3) laboratory measures of thyroid function, (4) clinical staging of hypothyroidism, and (5) neuropsychiatric comorbidities of hypothyroidism. Data sources Data sources include a systematic review of English articles using Ovid (1950–2018). Search terms included hypothyroidism, depression, and bipolar disorder. Additional studies were identified and added by searching references of articles in this database. Included topics focused on treatment of neuropsychiatric disorders with psychiatric drugs and adjunctive thyroid hormone replacement. Methods We created the database by identifying articles from multiple sources. Sources included the Ovid database, references of collected articles, and manual retrieval of articles on focused topics. Clinical information was summarized towards review objectives. We include a summary of the relevant basic sciences to enhance a thorough review. Results We found use of adjunctive treatment with thyroid hormone an acceptable approach to treating treatment-refractory or otherwise atypical presentations of mood and cognitive disorders. Given the prevalence of neuropsychiatric symptoms in subclinical hyperthyroidism and the severity and treatment-resistant symptoms, clinicians should rule out thyroid disorders in presentations of a mood disorder. Clinicians should consider an endocrine disruption in psychiatric patients whose mood symptoms remain treatment-refractory. Limitations The article does not discuss hyperthyroidism, which may predicate episodes of hypothyroidism in patients. Only articles with English-language abstract or full text were included. No quantitative synthesis is included as no meta-analysis was conducted. Risks of bias across studies include publication bias and selective reporting. Conclusions Hypothyroidism should be investigated in patients with neuropsychiatric symptoms of mood disorders. Adjunctive thyroid hormone treatment should be considered as a possible option for patients with refractory mood disorders.
Rhetoric in Neoliberalism: edited by Kim Hong Nguyen, Cham, Switzerland, Palgrave Macmillian, 2017, x + 234 pp., $139.00 (hardcover/softcover); $109.00 (e-book).

The encroachment of neoliberal institutions, policies, and ideas in the global sphere challenges rhetoricians to craft theories that respond to the increasing relevance of economic rationality in e...
Sleep-wake characteristics in a mouse model of severe traumatic brain injury: Relation to posttraumatic epilepsy.

Study objectives Traumatic brain injury (TBI) results in sequelae that include posttraumatic epilepsy (PTE) and sleep-wake disturbances. Here, we sought to determine whether sleep characteristics could predict development of PTE in a model of severe TBI. Methods Following controlled cortical impact (CCI) or sham injury (craniotomy only), CD-1 mice were implanted with epidural electroencephalography (EEG) and nuchal electromyography (EMG) electrodes. Acute (1st week) and chronic (months 1, 2, or 3) 1-week-long video-EEG recordings were performed after the injury to examine epileptiform activity. High-amplitude interictal events were extracted from EEG using an automated method. After scoring sleep-wake patterns, sleep spindles and EEG delta power were derived from nonrapid eye movement (NREM) sleep epochs. Brain CTs (computerized tomography) were performed in sham and CCI cohorts to quantify the brain lesions. We then employed a no craniotomy (NC) control to perform 1-week-long EEG recordings at week 1 and month 1 after surgery. Results Posttraumatic seizures were seen in the CCI group only, whereas interictal epileptiform activity was seen in CCI or sham. Sleep-wake disruptions consisted of shorter wake or NREM bout lengths and shorter duration or lower power for spindles in CCI and sham. NREM EEG delta power increased in CCI and sham groups compared with NC though the CCI group with posttraumatic seizures had lower power at a chronic time point compared with those without. Follow-up brain CTs showed a small lesion in the sham injury group suggesting a milder form of TBI that may account for their interictal activity and sleep changes. Significance In our TBI model, tracking changes in NREM delta power distinguishes between CCI acutely and animals that will eventually develop PTE, but further work is necessary to identify sleep biomarkers of PTE. Employing NC controls together with sham controls should be considered in future TBI studies.
Sexual Identity and its Association with Trajectories of Depressive Symptoms and Emotion Regulation Difficulties from Early to Middle Adolescence.

Few studies have examined how changes in sexual identity impact trajectories of depressive symptoms and emotion regulation difficulties. The current study addresses this gap in the literature by examining these associations over a three-year period in a community sample of adolescents (N = 177; Mage = 12.56; SD = 0.60; nmale = 95). Multilevel modeling revealed that youth who consistently held sexual minority identities from early to middle adolescence—but not youth with inconsistent sexual identity—demonstrated increases in depressive symptoms and emotion regulation difficulties relative to their heterosexual peers. Findings suggest that treatments that bolster emotion regulation abilities and address depressive symptoms may be of particular benefit to youth with consistent sexual minority identities from early to middle adolescence.
SCOPE: Synthesis-Based Constant Propagation Attack on Logic Locking

Hardware intellectual property (IP) piracy and misuse have introduced new challenges in the semiconductor industry as untrusted parties in the IP’s life cycle may clone, reverse-engineer, or extract important design secrets from an IP. A promising solution to protect a hardware IP against such attacks is to perform logic locking, where additional logic controlled by a secret key is inserted in strategic locations of an IP to lock the functionality when the correct key is not available. As a multitude of logic locking techniques has emerged in the past decade, the research community has also developed strong attacks against them to expose various vulnerabilities that can be exploited by an adversary to break the protection. While state-of-the-art logic locking solutions have demonstrated provable robustness against known attacks, there is a critical need to explore new attack vectors and mitigate them to achieve a higher level of protection. In this article, we present SCOPE, a novel synthesis-based constant propagation attack for security evaluation of logic locking techniques. SCOPE is oracle-less and requires no knowledge about the locking algorithm or the locked design by an attacker. The introduced attack performs a synthesis-based analysis on each individual key-input port and looks for meaningful design features that may help derive the correct key value. SCOPE offers two attack modes with varying complexity and effectiveness, a linear regression test, and an unsupervised machine-learning analysis. We perform SCOPE to a number of existing locking techniques and demonstrate that the average attack accuracy is 84.13% with high scalability in terms of design size. Based on the vulnerabilities identified by SCOPE, we provide a low-overhead countermeasure that can help mitigate such constant propagation attacks.
Electrophysiological effects and clinical utility of propafenone in children.

Aim This retrospective case series study sought to describe the safety and clinical effectiveness of propafenone for the control of arrhythmias in children with and without CHD or cardiomyopathy. Methods We reviewed baseline characteristics and subsequent outcomes in a group of 63 children treated with propafenone at 2 sites over a 15-year period Therapy was considered effective if no clinically apparent breakthrough episodes of arrhythmias were noted on the medication. Results Sixty-three patients (29 males) were initiated on propafenone at a median age of 2.3 years. CHD or cardiomyopathy was noted in 21/63 (33%). There were no significant differences between demographics, clinical backgrounds, antiarrhythmic details, side effect profiles, and outcomes between children with normal hearts and children with CHD or cardiomyopathy. Cardiac depression at the initiation of propafenone was more common amongst children with CHD or cardiomyopathy compared to children with normal hearts. Systemic ventricular function was diminished in 15/63 patients (24%) prior to starting propafenone and improved in 8/15 (53%) of patients once better rhythm control was achieved. Other than one child in whom medication was stopped due to gastroesophageal reflux, no other child experienced significant systemic or cardiac side effects during treatment with propafenone. Propafenone achieved nearly equal success in controlling arrhythmias in both children with normal hearts and children with congenital heart disease or cardiomyopathy (90% versus 86%, p = 0.88). Conclusion Propafenone is a safe and effective antiarrhythmic medication in children.
Internal nitrogen dynamics in stormwater pond sediments are influenced by pond age and inorganic nitrogen availability

Nitrogen (N) removal from stormwater runoff prior to its export to sensitive downstream water bodies is a common goal for urban stormwater ponds (SWPs). Denitrification removes nitrate (NO3−) from stormwater runoff by conversion to di-nitrogen gas (N2), permanently removing reactive N from the ecosystem. Typically, N removal in SWPs is quantified via mass balance approaches, but the internal biogeochemical mechanisms driving N dynamics in these engineered ecosystems are unclear. In this study, we quantified gaseous and dissolved inorganic N fluxes and sediment oxygen demand from sediment cores collected at residential SWPs ranging from 10 to 30 years old in two subtropical cities during the dry and wet seasons. To better understand biogeochemical process rates and drivers within SWP sediments, we exposed sediments to both ambient and elevated (to simulate stormwater runoff) water column nitrate concentrations. Under ambient concentrations, SWP sediments could be either net sources (via N-fixation) or sinks (via denitrification) for N, and net N2 flux was not significantly affected by background nitrate concentrations, sediment oxygen demand, or age. However, SWP sediments shifted to net denitrification under elevated nitrate conditions. Denitrification (positive net N2 flux) increased with SWP age, microbial activity, and net nitrate uptake (p < 0.05 for each). These results suggest that while denitrification is N limited under ambient conditions, SWPs have the capacity to rapidly process acute nitrate loading events and remove N from the water column via denitrification.
Document-centric OLAP in the schema-chaos world

Gaining business insights such as measuring the effectiveness of a product campaign requires the integration of a multitude of different data sources. Such data sources include in-house applications (like CRM, ERP), partner databases (like loyalty card data from retailers), and syndicated data sources (like credit reports from Experian). However, different data sources represent the same semantic attributes in different ways. E.g., two XML schemas for purchase orders may represent price as /SAP46Order/Product/Price or /PeopleSoft/Item/Sold/ Cost, respectively. The different paths to the same semantic information depend on the schema, making it difficult to index the data and for query languages such as XQuery to process aggregation queries. Shredding the XML documents is not feasible due to the vast number of different schemas and the complexity of the XML documents. The only known approach today is to ETL every single document into a common schema, and then use XQuery on the transformed data to perform aggregation. Such a solution does not scale well with the number of schemas or their natural evoluation. This paper presents a robust solution to document-centric OLAP over highly-heterogeneous data. The solution is based on the exploitation of text-indexing that provides the necessary flexibility and well-established techniques for aggregation (like star-joins and bitmap processing). We present the overall architecture and the experimental performance results from our implementation.
Operating Hours ofD.S. Manufacturing Plants, 1976’1988, and Their Significance for Productivity Change

This paper1 provides annual estimates of weekly operating hours of manufacturing plants in the United States for the period 1976–1988 and their significance for productivity change. It is a sequel to two earlier studies, the first of which (Foss 1981) found that manufacturing plants were working about 25 percent more hours per week in 1976 than in 1929. The second study (Foss 1984) found that plant hours in manufacturing had increased over the post-World War II period and that for nonf arm business as a whole capital hours had increased both from 1929 and from 1948 to the mid-1970s.
Treatment of intracoronary thrombus with microwave thermal balloon angioplasty

Microwave energy was used to evaluate the treatment of vascular thrombus in a canine model of coronary thrombus. It was found that with the microwave energy, it was possible to coagulate and laminate intracoronary thrombus, providing a more effective resolution of intracoronary thrombus than with conventional balloon angioplasty. >
The many paths to quality core assets

Can all of the different approaches to software product line operation lead to quality core assets? Some organizations use a recognized method such as the Software Engineering Institute’s Framework for Product Line Practice [4] while others use a homegrown variant of their non-product line process. Some organizations iteratively mature their core assets while others build proactively.
TWO-WAY FLEXURE OF STEEL-DECK-REINFORCED SLABS

An elastically orthotropic finite element model with uniform thickness is developed that simulates the behavior of a structurally orthotropic steel-deck-reinforced concrete slab. The elastically orthotropic model accurately predicts the uncracked behavior of previously tested steel-deck-reinforced concrete slabs. The linear, elastic, uncracked behavior of a single panel of a typical steel-deck-reinforced concrete slab is examined for simply supported and fixed boundaries. Deflections and bending moments for two-way flexural action are compared with similar values for one-way bending. An expression is proposed for computing the optimum aspect ratio for a given orthotropic steel-deck-reinforced concrete slab. This study indicates that it is feasible to consider two-way action in the design of steel-deck-reinforced concrete slabs.
Stimulation of Protein Phosphatase-1 Activity by Phorbol Esters. Evaluation of the regulatory role of protein kinase C in insulin action.

In this study, we examined the role of insulin, protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) cascade in activation of protein phosphatase-1 (PP-1) by using three complementary approaches. First, differentiated L6 cells were acutely exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA, 400 nM) to activate PKC. In these cells, TPA caused 32% stimulation of PP-1 activity. The PP-1 stimulation by TPA was comparable to stimulation by insulin (t1/2 = 1 min and EC50 = 5 nM) with a maximum effect in 5 min. The effects of insulin and TPA were not additive. Insulin and TPA also stimulated MAPK (> 2-fold increase over basal, with myelin basic protein as a substrate). ML-9, a myosin light chain kinase inhibitor, blocked the effects of insulin and TPA on both MAPK and PP-1 activation. In the second approach, PKC was down-regulated by chronic treatment with TPA. In these cells subsequent effects of insulin on MAPK and PP-1 activation were blocked, without an effect on basal enzyme levels. In the third approach, two selective inhibitors of PKC, calphostin and chelerythrine chloride, were used to inhibit PKC. These inhibitors completely prevented insulin and TPA stimulation of MAPK and PP-1 and blocked insulin-induced translocation of PKC to the plasma membranes. We conclude that PKC plays an important role in insulin stimulation of PP-1 via the activation of MAPK cascade.
Protograph-based Raptor-like LDPC codes for the binary erasure channel

This paper designs protograph-based Raptor-like (PBRL) codes as a class of rate-compatible (RC) LDPC codes for binary-erasure channels (BEC). Similar to the Raptor Codes, the RC property is achieved by X-OR operations of the precoded bits. The additional parity bits, which lower the rate, are selected such that their connections in the protograph optimize the density evolution threshold. In order to avoid problematic graphical objects in the CPEG lifted bipartite graph and guarantee the linear growth distance property some constraints are imposed in the threshold optimization algorithm. Simulation results are presented for information block sizes of k = 1032, and k = 16384. These results are compared with finite blocklength bounds of Polyanskiy, Poor, Verdu (PPV) as well as several asymptotic bounds. The k = 1032 code family operates at various rates in the range of 8/9 to 8/48 and has an average normalized threshold gap of 5.56% from capacity. The k = 16384 code family operates at rates 8/10 to 8/32 and has an average normalized threshold gap of 3.27% from capacity.
Making kinship in the wake of history: Gendered violence and older child adoption

In the United States children enter the state‐run foster care system because of a range of conditions considered to be “abuse and neglect.” Children entering the system are vulnerable to additional bureaucratically ordained violence, some of which is generic and some of which is gendered. This paper situates the exposure of children in state care to gendered violence in a context of poverty, the scaling back of state social welfare programs, and the interaction of gender, family, and race ideologies. The consequences of early exposure to gendered violence are explored through narratives by parents of girls adopted over the age of two who had been subject to sexual and other forms of gendered violence in or before foster care. The need for intervention on the conditions leading to foster care, better monitoring of children's well‐being in foster care, and training and support of foster and adoptive parents regarding recovery from gendered violence is stressed, as is the need to address the ideological cond...