cssi/SciSciGPT-SciSciNet huggingface dataset:
Composite Lymphocyte-Rich Thymoma and Peripheral T-Cell Lymphoma Not Otherwise Specified: Case Report and Literature Review

The simultaneous occurrence of thymoma and peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) has not been previously reported, to our knowledge. We describe a 59-year-old ethnic Filipina woman with myasthenia gravis who was found to harbor an invasive lymphocyte-rich thymoma (World Health Organization [WHO] type B1). Subsequent pathologic examination of her mediastinal and abdominal lymph nodes revealed concurrent PTCL-NOS. A bone marrow examination revealed T-cell lymphoma, which was confirmed by flow cytometric and T-cell receptor gene rearrangement analysis. * NHL : non-Hodgkin lymphoma WBC : white blood cell PTCL-NOS : peripheral T-cell lymphoma not otherwise specified MRI : magnetic resonance imaging CT : computed tomographic WHO : World Health Organization HTLV-1 : human T-cell leukemia virus type 1 HTLV-2 : human T-cell leukemia virus type 2 PCR : polymerase chain reaction TCR : T-cell receptor CML : chronic myelogenous leukemia
NASA's advanced control law program for the F-8 digital fly-by-wire aircraft

This paper briefly describes the NASA F-8 Digital Fly-By-Wire (DFBW) and Langley Research Center's role in investigating and promoting advanced control laws for possible flight experimentation. The primary purpose of the paper is to provide background material for the papers that follow which describe some of the F-8 DFBW adaptive control law studies. The paper provides a brief description of the Phase II DFBW F-8 aircraft and its control system, discusses some of the advanced control law study objectives and guidelines, and provides some mathematical models which are useful in the control analysis problem.
A relative technique for characterization of PCV error of large aperture antennas using GPS data

The Federal Aviation Administration's (FAA) local area augmentation system (LAAS) is a code-based differential global positioning system (DGPS) to be used for guidance of aircraft during the approach and landing phase of flight. Code-based multipath error was a limiting factor in the LAAS meeting category III accuracy requirements for this phase of flight. Consequently, a large aperture antenna was proposed for use at each ground-based DGPS reference site to reduce the impact of code-based multipath error to less than 0.25 m. The large aperture antenna accomplishes this task at the expense of providing limited coverage in the vertical plane (0-35/spl deg/). An ancillary high-zenith antenna is then necessary to track satellites from 35-90/spl deg/ in elevation. Phase center variation (PCV) has been observed to be a significant source of GPS error when translating the accumulated carrier phase (ACP) and pseudorange (PR) data between the two aforementioned antennas to a common phase center. This paper presents a relatively simple method for reducing the error caused by the PCV of a large aperture antenna. This is done by comparing the GPS ACP data from a large aperture vertically polarized dipole array antenna with undesirably large PCV (more than 20 cm), with similar data from a right-hand circularly polarized high-zenith antenna with small PCV (relative to physical center of array). A triple-differencing technique of the ACP data between the two antennas across successive epochs is used to characterize the PCV of the large aperture antenna as a function of elevation angle. The PCV correction factor is applied to the ACP data from the large aperture antenna array. The ACP data from the two antennas are then combined in software to appear as one antenna with minimal offset from PCV. A field test that employed this technique is described and test results are provided. This technique confers an advantage over other methods for PCV determination, which require precision mounting and/or robotic motion capabilities, or the use of an antenna range.
CTLA4 blockade increases Th17 cells in patients with metastatic melanoma

Th17 cells are CD4+ cells that produce interleukin 17 (IL-17) and are potent inducers of tissue inflammation and autoimmunity. We studied the levels of this T cell subset in peripheral blood of patients treated with the anti-CTLA4 antibody tremelimumab since its major dose limiting toxicities are inflammatory and autoimmune in nature. Peripheral blood mononuclear cells (PBMC) were collected before and after receiving tremelimumab within two clinical trials, one with tremelimumab alone (21 patients) and another together with autologous dendritic cells (DC) pulsed with the melanoma epitope MART-126–35 (6 patients). Cytokines were quantified directly in plasma from patients and after in vitro stimulation of PBMC. We also quantified IL-17 cytokine-producing cells by intracellular cytokine staining (ICS). There were no significant changes in 13 assayed cytokines, including IL-17, when analyzing plasma samples obtained from patients before and after administration of tremelimumab. However, when PBMC were activated in vitro, IL-17 cytokine in cell culture supernatant and Th17 cells, detected as IL-17-producing CD4 cells by ICS, significantly increased in post-dosing samples. There were no differences in the levels of Th17 cells between patients with or without an objective tumor response, but samples from patients with inflammatory and autoimmune toxicities during the first cycle of therapy had a significant increase in Th17 cells. The anti-CTLA4 blocking antibody tremelimumab increases Th17 cells in peripheral blood of patients with metastatic melanoma. The relation between increases in Th17 cells and severe autoimmune toxicity after CTLA4 blockade may provide insights into the pathogenesis of anti-CTLA4-induced toxicities. Clinical trial registration numbers: NCT0090896 and NCT00471887
Psychological Component in the Etiology of Geographic Tongue

SYNOPSIS IN INTERLINGUACOMPONENTE PSYCHOLOGIC IN LE ETIOLOGIA DE LINGUA GEOGRAPHIC. — Sub) stress emotional, le linguas de 11 afficite studentes se pejorava e illos de 4 se meliorava. Le profilos medie de MMPI (Inventorio Multiphasic de Personalitate Minnesota) del afficite studentes esseva generalmente elevate in comparation con illos del subjectos de controlo. Duo de 35 subjectos de control e 15 de 35 afficite studentes habeva profilos de MMPI suggestive de disturbation psychologic. Le morbo esseva significativemente plus prevalente inter adultos mentalmente malade que inter adultos normal o mentalmente deficiente. Iste evidentia monstra que stress emotional es un factor etiologic in lingua geographic, sed investigationes additional es necessari pro determinar su importantia relative.
In-service aging and degradation of 345 kV EPDM transmission line insulators in a coastal environment

Aging and degradation of 345 kV ethylene propylene diene monomer (EPDM) transmission line insulators removed from service is presented. These suspension type insulators were installed in a New Hampshire coastal area in 1995 and were removed in 2000 after unexplained outages in that structure. The purpose of this paper is to better understand the aging and degradation mechanisms of EPDM insulators in service. The insulators showed severe chalking and discoloration and partial loss of hydrophobicity on the side facing the sun. The surface structural changes were studied in detail using advanced surface analysis techniques, such as attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). For the first time, the significant differences in surface properties between the chalked/discolored (white) and the other surfaces (dark) were studied quantitatively. The Fourier transform infrared (FTIR) absorption spectra showed a significant decomposition of the CH groups of the white surface, elucidating the effect of photo-oxidation on the EPDM polymer. The SEM micrographs showed the cracking of the surfaces. The XPS spectra showed the formation of various polar carboxyl groups and the presence of high surface energy compounds, such as silica, and silicates. This study provided valuable basic information on the changes in the surface properties of EPDM insulators during service in a coastal environment.
An objective measure of lateral epicondylitis

Purpose: The purpose of this study was to develop and determine the efficacy of a middle digit isokinetic eccentric strength dynamometer (MDD) in two groups of subjects. Methods: The first group was composed of individuals without physician diagnosed lateral epicondylitis (13 males and 14 females), and the second group was composed of individuals who had physician diagnosed lateral epicondylitis (13 males and 14 females). A middle digital extension isokinetic dynamometer measured eccentric isokinetic torque, work, power, and angle at peak torque of the third finger. Results : Test-retest correlation values ranged from 0.83 to 0.45. ANOVA indicated a significant difference in work, power, and angle at peak torque were indicated between the two subject groups. Conclusion: The middle digital extension isokinetic dynamometer appears to provide an acceptable means of evaluating effects of lateral epicondylitis therapy.
Modular solution of dynamic multi-phase systems

Binary Decision Diagram (BDD)-based solution approaches and Markov chain based approaches are commonly used for the reliability analysis of multi-phase systems. These approaches either assume that every phase is static, and thus can be solved with combinatorial methods, or assume that every phase must be modeled via Markov methods. If every phase is indeed static, then the combinatorial approach is much more efficient than the Markov chain approach. But in a multi-phased system, using currently available techniques, if the failure criteria in even one phase is dynamic, then a Markov approach must be used for every phase. The problem with Markov chain based approaches is that the size of the Markov model can expand exponentially with an increase in the size of the system, and therefore becomes computationally intensive to solve. Two new concepts, phase module and module joint probability, are introduced in this paper to deal with the s-dependency among phases. We also present a new modular solution to nonrepairable dynamic multi-phase systems, which provides a combination of BDD solution techniques for static modules, and Markov chain solution techniques for dynamic modules. Our modular approach divides the multi-phase system into its static and dynamic subsystems, and solves them independently; and then combines the results for the solution of the entire system using the module joint probability method. A hypothetical example multi-phase system is given to demonstrate the modular approach.
Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

Rationale: Neutrophil extracellular trap (NET) formation promotes vascular damage, thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in diseased arteries. Peptidylarginine deiminase inhibition is a strategy that can decrease in vivo NET formation. Objective: To test whether peptidylarginine deiminase inhibition, a novel approach to targeting arterial disease, can reduce vascular damage and inhibit innate immune responses in murine models of atherosclerosis. Methods and Results: Apolipoprotein-E (Apoe ) −/− mice demonstrated enhanced NET formation, developed autoantibodies to NETs, and expressed high levels of interferon-α in diseased arteries. Apoe −/− mice were treated for 11 weeks with daily injections of Cl-amidine, a peptidylarginine deiminase inhibitor. Peptidylarginine deiminase inhibition blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model. Decreases in atherosclerosis burden were accompanied by reduced recruitment of netting neutrophils and macrophages to arteries, as well as by reduced arterial interferon-α expression. Conclusions: Pharmacological interventions that block NET formation can reduce atherosclerosis burden and arterial thrombosis in murine systems. These results support a role for aberrant NET formation in the pathogenesis of atherosclerosis through modulation of innate immune responses.
Ovarian Steroidogenesis in the Proestrous Hamster

In the proestrous hamster, in response to the LH surge, there is a dramatic and sustained increase in serum progesterone (P) and transitory increases in testosterone (T), estrone (E1 ) and estradiol-1 7� (E2). Ovarian steroidogenesis in the proestrous hamster was analyzed in detail by studying: 1) concentrations of these steroids in the whole ovary, antral follicles (AF) and the nonantral follicular portion of the ovary (NAO) at 1200 h (prior to the LI-I surge), 1500 h (during the LH surge) and 1800 h (after the LH surge); 2) in vitro steroidogenic production by the AF and NAO, as well as the whole ovary (removed before 1200 h, 1500 h and 1800 h and 3) in vitro effects of LU, FSH and P on steroidogenesis of ovaries removed before the LH surge and incubated for 2 h. P concentration was the same in AF and NAO at 1200 h but increased slightly in the AF with the onset of the LH surge. Both the concentration and production rate of P increased from a minimum at 1200 h (1 ng/mg/h) to a maximum by 1800 h (30 ng/mg/h) in the ovary, AF and NAO. On the other hand, the concentration ofT, E1 and E2 was selectively greater in the AF at all times. Maximum T production occurred in the ovaries removed during the LH surge (150 pg/mg/h) followed by a significant decline by 1800 h. However, AF produced negligible amounts ofT at all times. In the NAO, the production of T was essentially the same (about 20 pg/mg/h) in all 3 incubations. The production of E1 and E2 was much greater in the AF than in the NAO, especially between 1200-1500 h. By 1800 h, the levels and synthetic capacity for estrogens in the ovary, AF and NAO declined to baseline levels, while the production of P was still very high. These studies indicate that in the proestrous hamster, steroidogenesis in the NAO which largely represents the interstitial compartment is limited to the production of P and androgens and only a negligible fraction passes down the pathway to form estrogens. On the other hand, steroidogenesis is more complete in the AF where it can proceed efficiently as far as estrogens. LH (5-250 ng/ml) added in vitro increased the production rate of all steroids whereas 1 ng LU increased only the synthesis of E2. FSH (100-200 ng/ml) also stimulated E2 production but not E1. Higher concentration of FSH (250 ng/ml) resulted in overall increases in P, T, E1 and E2 possibly due to contamination with LH. Exogenous P (10, 100 ng/ml) had no effect on T or E1 synthesis, but E2 production was enhanced.
Diculty of selecting among multilevel models using predictive accuracy

As a simple and compelling approach for estimating out-of-sample prediction error, cross-validation naturally lends itself to the task of model comparison. However, even with moderate sample size, it can be surprisingly dicult to compare multilevel models based on predictive accuracy. Using a hierarchical model t to large survey data with a battery of questions, we demonstrate that even though cross-validation might give good estimates of pointwise out-of-sample prediction error, it is not always a sensitive instrument for model comparison.
Input correlation with the a.s.w. storage correlator

By correlating during read-in, we correlate signals of much greater length than could be stored within the device, thereby obtaining a large improvement in t.b. product.
Examining Time to Initiation of Biologic Disease-modifying Antirheumatic Drugs and Medication Adherence and Persistence Among Texas Medicaid Recipients With Rheumatoid Arthritis.

Abstract Purpose Little is known about the transition from nonbiologic disease-modifying antirheumatic drugs (DMARDs) to biologic DMARDs or about individual nonbiologic DMARD use patterns among patients with rheumatoid arthritis (RA). This study examined time to initiation of biologic DMARDs and nonbiologic DMARD medication adherence and persistence among Texas Medicaid recipients with RA taking nonbiologic DMARDs. Methods In this retrospective study (July 1, 2003–December 31, 2010) of the Texas Medicaid database, patients were aged 18 to 62 years at index, were diagnosed with RA (International Classification of Diseases, Ninth Revision, Clinical Modification, code 714.xx), had no claims for nonbiologic or biologic DMARDs in the preindex period, and had a minimum of 2 prescription claims for the same nonbiologic DMARD in the postindex period. Kaplan-Meier survival analysis and log-rank tests were used to compare time to initiation of biologic DMARDs according to nonbiologic DMARD type and therapy. Adherence and persistence were examined according to nonbiologic type and therapy by using ANOVA models and χ2, Duncan, and t tests. Findings On average, patients were 47.9 (±10.4) years of age, mostly female (89.1%) and Hispanic (55.2%). Methotrexate (MTX) and leflunomide (LEF) users took the shortest time to initiate biologic DMARDs (207 [190] days and 188 [205] days, respectively). LEF users had the highest mean adherence of 37.5% (27.5%), which was similar to MTX users (35.7% [26.9%]), whereas dual-therapy users had the lowest mean adherence at 17.1% (14.4%). Sulfasalazine users (108 [121] days) had the lowest persistence, whereas LEF (227 [231] days) and MTX (211 [222] days) users had the longest persistence. Nonbiologic DMARD monotherapy users were more adherent than dual-therapy users (32.6% [25.8%] vs 17.1% [14.4%]). Implications These results should be interpreted in light of some study limitations, such as using proportion of days covered as a proxy for adherence, not having clinical data to control for RA severity, and lack of generalizability to all US populations. Given the study findings, both clinicians and other decision makers may want to investigate the potential driving factors of initiation of biologic DMARDs to provide effective RA management and consider patient education programs to enhance medication adherence and persistence to RA medications.
Free wandering cells and cortisone.

ConclusionIn tissue cultures of embryonic skin it can be demonstrated that, of the cell types present, the free wandering cells are the most sensitive to the hormone. All wandering cell movement can be brought to a stop in cultures in which fibroblastic activity remains undisturbed. This observation is supported by the behavior of cortisone-treated spleen fragments.
All of the Above: How Fiscal, Political, and Workforce Traits Affect Pension Funding

Public sector pension funding varies significantly across the states, a phenomenon often linked with budget conditions, but do political factors also play a role? Utilizing data collected between 2...
A Scientific Vocation: Professional Dentistry in American Society

(1943). A Scientific Vocation: Professional Dentistry in American Society. The Journal of Higher Education: Vol. 14, No. 9, pp. 500-500.
Picturizing narrative innovation: a bird’s eye view of hypervisualized intertextuality in Stephen Kelman’s Pigeon English

Via the use of ‘seeing’ strategies (pictographization) rather than just ‘telling’ strategies (textualization), Booker-prize shortlister, Stephen Kelman, in Pigeon English, successfully synergizes m...
Study on precise surgery of paediatric DDH treatment based on modern design and manufacture technology

The development dysphasia of the hip(DDH) is an illness commonly found among children.In the conventional treatment to DDH,the modification of the bone position is based on the analysis of feature parameters to 2D X-ray photo and the surgical result is highly dependent upon surgeon's personal experience.Thus,the quality and efficiency of the surgery is yet to be improved.Aiming at this problem,some computer aided techniques,such as image processing,reverse engineering and rapid prototyping are applied to combine with surgery to construct precise and controllable surgery method based on 3D virtual model and bio-model.With this method,the feature parameters are first precisely obtained from virtual model and bio-model.The operation schedule is then made and pre-operated.At last the aided tools needed in the practical surgery are designed and manufactured.The applications in the surgery of DDH demonstrate that the method can greatly improve the quality and efficiency of surgery.
Classification of membrane transporters.

In summation, classification of membrane transporters is a challenging issue. One must consider not only their primary structure, but one must also ponder their function, topology, evolutionary origins, substrate specificity, and structural architecture. It is not known to what extent convergence and divergence played a role in the evolutionary progression of membrane transporters. A major question remaining to be resolved is whether common ancestry indeed implies similar folding into a common molecular architecture, as commonly assumed for soluble proteins. Most transporter gene families share a similar membrane topology, and the primary structure is highly conserved among members of the same gene family. Transporter families often include diverse functions in terms of substrate specificity and translocation mechanism. However, sequence similarities among different transporter families are often limited. It is difficult to establish evolutionary relationships between distant transporter families because of the recurrent TMD– loop structure, with restricted amino acid content. For a better understanding of these polytopic membrane proteins, we must determine how their structural diversity has evolved, and how the primary structures fold into the mature transport protein. Much remains to be learned about the biology and structure of membrane transporters.
Using Eye Tracking to Investigate Reading Patterns and Learning Styles of Software Requirement Inspectors to Enhance Inspection Team Outcome

Background -- Inspecting requirements and design artifacts to find faults saves rework effort significantly. While inspections are effective, their overall team performance rely on inspectors' ability to detect and report faults. Our previous research showed that individual inspectors have varying LSs (i.e., they vary in their ability to process information recorded in requirements document). To extend the results of our previous LS research, this paper utilizes the concept of eye tracking (to record eye movements of inspectors) along with their LSs to detect reading patterns of inspectors during requirements inspections. Aim -- The objective of this research is to analyze the reading trends of effective and efficient inspectors using eye movement and LS data of individual inspectors and virtual inspection teams. Method -- The current research uses data (LS, eye tracking, and inspection) from thirteen inspectors to find its impact on inspection effectiveness and efficiency. Results -- Results from this study show that, inspectors who detect more faults during inspection, focus significantly more at the fault region to find and report faults as opposed to comprehending requirements information. Results also showed Inspection teams with diverse inspectors outperform similar teams and spend more time in comprehending information at the fault region. Additionally, results showed that inspectors with SEQ LS significantly tends to focus more at fault locations and are preferred for inspection. Conclusion -- These results can aid the selection of inspectors during the inspection process thus improving software quality
Captivate short answer evaluator

We propose a model for automatically scoring short textual responses in e-learning content. Natural Language Processing (NLP) techniques are used to extract syntactic and semantic structures from the content, which are used to build the model. The proposed approach is planned to be implemented in Adobe Captivate - a popular end-to-end e-learning tool.
An Emerging Model of Knowledge for Youth Development Professionals

A model of knowledge for youth development professionals that is comprised of five knowledge domains: 1) Foundational Knowledge of Positive Youth Development; 2) Knowledge of Youth; 3) Knowledge of Group Facilitation; 4) Knowledge of Contexts and Organizational Systems and; 5) Specialized Youth Development Knowledge is proposed in this paper. The model is intended for use in youth development programs, which have been associated with better outcomes for participants when compared to other types of youth programs. The development of the knowledge base is framed by seminal research on teacher knowledge and informed by practice-oriented research in the out-of-school time field and literature on the quality of youth development programs.
Robotic Assisted Laparoscopic Prostatectomy after High Intensity Focused Ultrasound Failure.

Background. Prostate cancer is the most common cancer diagnosed in men. As new focal therapies become more popular in treatment of prostate cancer, failure cases requiring salvage therapy with either surgical or other techniques are being reported. Objective. To report the options in treatment of prostate cancer after recurrence or failure of the primary treatment modality. Methods. We report a salvage robotic assisted laparoscopic radical prostatectomy (RALP) for prostate cancer recurrence following high intensity focused ultrasound treatment (HIFU) in the United States. Results. A 67-year-old man who underwent HIFU treatment for prostate adenocarcinoma 2 years prior was presented with a rising prostate specific antigen of 6.1 ng/mL to our clinic. A biopsy proven recurrent disease in the area of previous treatment documented the failure of treatment. The patient elected to undergo a salvage RALP. The operation time was 159 minutes. The patient was discharged from the hospital on postoperative day 1 with no complications. The catheter was removed on post-op day 10. The patient reserved sexual function and urinary continence. The PSA levels on 6 months’ follow-up are undetectable. Conclusions. Salvage RALP is an effective and safe treatment choice for recurrent prostate adenocarcinoma following failed HIFU treatment if operated by an experienced surgeon.
Collaborative botnet detection with partial communication graph information

Botnets have long been used for malicious purposes with huge economic costs to the society. With the proliferation of cheap but non-secure Internet-of-Things (IoT) devices generating large amounts of data, the potential for damage from botnets has increased manifold. There are several approaches to detect bots or botnets, though many traditional techniques are becoming less effective as botnets with centralized command & control structure are being replaced by peer-to-peer (P2P) botnets which are harder to detect. Several algorithms have been proposed in literature that use graph analysis or machine learning techniques to detect the overlay structure of P2P networks in communication graphs. Many of these algorithms however, depend on the availability of a universal communication graph or a communication graph aggregated from several ISPs, which is not likely to be available in reality. In real world deployments, significant gaps in communication graphs are expected and any solution proposed should be able to work with partial information. In this paper, we analyze the effectiveness of some community detection algorithms in detecting P2P botnets, especially with partial information. We show that the approach can work with only about half of the nodes reporting their communication graphs, with only small increase in detection errors.
Effects of plant and animal waste-based compost amendments on the soil food web, soil properties, and yield and quality of fresh market and processing carrot cultivars

A substantial knowledge gap exists on how compost source and rate of application affect nematode community-based soil food web structure, soil health, soil physiochemistry, and crop yield and quality in short- and full-season crops. We tested effects of plant (PC)- and animal (AC)-based compost at 1, 1.5 and 2× the standard nitrogen (N) rate on processing carrot ‘Cupar’ and fresh market ‘Sugarsnax 54’ (short-season crop) over 2-3 growing seasons. Low abundance of nematodes and domination of herbivores and bacterivores indicate that the field is biologically stressed. While outcomes of most measured parameters varied by compost source and/or rate, an increase in soil food web structure with time was most consistent. A combination of the variable outcomes and correlation patterns suggest that a multifactor analysis may best quantify compost-driven changes in soil ecosystems as opposed to looking for changes in a single parameter.
Implications of false-positive results for future cancer screenings.

BACKGROUND False-positive cancer screening results may affect a patient's willingness to obtain future screening. METHODS The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast, prostate, or colorectal cancer screening test results (repeat breast imaging or negative breast biopsy ≤3 months after screening mammography, repeat prostate-specific antigen [PSA] test ≤3 months after PSA test result ≥4.0 ng/mL or negative prostate biopsy ≤3 months after any PSA result, or negative colonoscopy [without biopsy/polypectomy] ≤6 months after a positive fecal occult blood test). Outcomes were up-to-date status with breast or colorectal cancer screening. Covariates included prior screening history, clinical information (eg, family history, obesity, and smoking status), comorbidity, and demographics. RESULTS Women were more likely to be up to date with breast cancer screening if they previously had false-positive mammography findings (adjusted odds ratio [AOR], 1.43 [95% confidence interval, 1.34-1.51] without breast biopsy and AOR, 2.02 [95% confidence interval, 1.56-2.62] with breast biopsy; both P<.001). The same women were more likely to be up to date with colorectal cancer screening (AOR range, 1.25-1.47 depending on breast biopsy; both P<.001). Men who previously had false-positive PSA testing were more likely to be up to date with colorectal cancer screening (AOR, 1.22 [P = .039] without prostate imaging/biopsy and AOR, 1.60 [P = .028] with imaging/biopsy). Results were stronger for individuals with more false-positive results (all P≤.005). However, women with previous false-positive colorectal cancer fecal occult blood test screening results were found to be less likely to be up to date with breast cancer screening (AOR, 0.73; P<.001). CONCLUSIONS Patients who previously had a false-positive breast or prostate cancer screening test were more likely to engage in future screening. Cancer 2018;124:2390-8. © 2018 American Cancer Society.
Neuroendocrine Secretion and Biological Rhythms in Man

All biological organisms demonstrate chronobiological rhythms which characterize their responses to both short-term and long-term environmental changes. All the hypothalamic and pituitary and many but not all of the peripheral endocrine hormones have been shown to have complex periodic patterns of secretion and circulation in the blood.
Holographic calculation of two-point correlation functions of CFT stress tensor in the BMS gauge and flat-space holography

In this paper, we use the holographic renormalization method to calculate the two-point correlation functions of the CFT stress tensor. In the gravity side, we write the asymptotically AdS spacetimes in the BMS gauge and apply the standard holographic renormalization method for these space-times. The significance of using multi-point functions in this gauge is that its flat-space limit is well-defined. We discuss this point in the last section of the paper.
Natural Law, Property, and Welfare Rights

It is a distinct pleasure to contribute to this festschrift volume honoring Joseph Boyle. I have admired, and learned much from, the wide range Dr. Boyle’s scholarship—his contributions to so-called “revised” natural law epistemology, his analysis of the moral status of nuclear deterrence as a strategy, and his perceptive discussions of particular issues in bioethics and medical ethics.
Review of Write No Matter What: Advice for Academics

This is a review of the book Write No Matter What: Advice for Academics by Joli Jensen (University of Chicago Press, 2017).
Three-Dimensional CeO2 Woodpile Nanostructures To Enhance Performance of Enzymatic Glucose Biosensors.

Fabrication of detection elements with ultrahigh surface area is essential for improving the sensitivity of analyte detection. Here, we report a direct patterning technique to fabricate three-dimensional CeO2 nanoelectrode arrays for biosensor application over relatively large areas. The fabrication approach, which employs nanoimprint lithography and a CeO2 nanoparticle-based ink, enables the direct, high-throughput patterning of nanostructures and is scalable, integrable, and of low cost. With the convenience of sequential imprinting, multilayered woodpile nanostructures with prescribed numbers of layers were achieved in a “stacked-up” architecture and were successfully fabricated over large areas. To demonstrate application as a biosensor, an enzymatic glucose sensor was developed. The sensitivity of glucose sensors can be enhanced simply by increasing the number of layers, which multiplies surface area while maintaining a constant footprint. The four-layer woodpile nanostructure of CeO2 glucose sensor ...
Patterns of Social Media Use Among Adolescents Who Are Psychiatrically Hospitalized

Adolescents' use of social media (SM) has increased drastically in recent years, with more than 80% of teens now belonging to sites such as Instagram, Snapchat, and Facebook.1 This has critical implications for youths' psychosocial development. Research increasingly supports a differential susceptibility model of media effects,2 whereby certain adolescents show increased risk for negative effects of SM use. Emerging research with community samples of youth suggest that mental health concerns may be one factor that heightens vulnerability to adverse SM experiences. In particular, youth with internalizing symptoms are more likely to report negative emotional responses to SM activity.3 In addition, youth with suicidal thoughts or behaviors are more likely to experience cybervictimization, and may be at risk for exposure to suicide-related SM content.4 Despite this preliminary evidence, almost no research to date has examined SM use among youth with clinically severe psychiatric presentations. This has significantly limited our understanding of a central feature in the lives of youth with mental illness. To address this limitation, we examined SM experiences among a large sample of psychiatrically hospitalized adolescents. We sought to determine the prevalence of positive and negative SM experiences in this population, and to explore differences in SM use based on diagnostic presentation.
U.S. farmers’ sense of place and its relation to conservation behavior

Abstract State and federal governments collectively spend billions of dollars on conservation programs designed to address nonpoint source pollution from working agricultural landscapes. Previous research has attempted to identify why farmers adopt conservation practices and enroll in conservation programs, but more work is needed to better understand management decisions in specific geo-spatial contexts. Sense of place provides one theoretical approach to accomplish this objective. This study uses mail survey methodology to test a sense of place scale in an American Midwestern agricultural landscape. Factor and principal component analysis suggests sense of place functions as a one-dimensional construct in this setting. However, two subcomponents identified in other studies (place attachment and place identity) have significant effects on specific conservation behaviors where the overall construct of sense of place does not. Insights are gained into the applicability of sense of place theory to a working landscape, as well as the factors contributing to agricultural conservation behavior.
Secure indoor positioning against signal strength attacks via optimized multi-voting

Indoor positioning systems (IPSes) can enable many location-based services in large indoor venues where GPS signals are unavailable or unreliable. Among the most viable types of IPSes, RSS-IPSes rely on ubiquitous smartphones and indoor WiFi infrastructures and explore distinguishable received signal strength (RSS) measurements at different indoor locations as their location fingerprints. RSS-IPSes are unfortunately vulnerable to physical-layer RSS attacks that cannot be thwarted by conventional cryptographic techniques. Existing defenses against RSS attacks are all subject to an inherent tradeoff between indoor positioning accuracy and attack resilience. This paper presents the design and evaluation of MV-IPS, a novel RSS-IPS based on weighted multi-voting, which does not suffer from this tradeoff. In MV-IPS, every WiFi access point (AP) that receives a user's RSS measurement gives a weighted vote for every reference location, and the reference location that receives the highest accumulative votes from all APs is output as the user's most likely position. Trace-driven simulation studies based on real RSS measurements demonstrate that MV-IPS can achieve much higher positioning accuracy than prior solutions no matter whether RSS attacks are present.
Expression of Phosphofructokinase Is Not Sufficient to Enable Embden-Meyerhof-Parnas Glycolysis in Zymomonas mobilis ZM4

Zymomonas mobilis is a bacterium that produces ethanol from glucose at up to 97% of theoretical efficiency on a carbon basis. One factor contributing to the high efficiency of ethanol production is that Z. mobilis has a low biomass yield. The low biomass yield may be caused partly by the low ATP yield of the Entner-Doudoroff (ED) glycolytic pathway used by Z. mobilis, which produces only one ATP per glucose consumed. To test the hypothesis that ATP yield limits biomass yield in Z. mobilis, we attempted to introduce the Embden-Meyerhof-Parnas (EMP) glycolytic pathway (with double the ATP yield) by expressing phosphofructokinase (Pfk I) from Escherichia coli. Expression of Pfk I caused growth inhibition and resulted in accumulation of mutations in the pfkA gene. Co-expression of additional EMP enzymes, fructose bisphosphate aldolase (Fba) and triose phosphate isomerase (Tpi), with Pfk I did not enable EMP flux, and resulted in production of glycerol as a side product. Further analysis indicated that heterologous reactions may have operated in the reverse direction because of native metabolite concentrations. This study reveals how the metabolomic context of a chassis organism influences the range of pathways that can be added by heterologous expression.
Coda: Genres of Futurity

This coda crystalizes my argument about contemporary dystopian and apocalyptic narratives. Twenty-first-century dystopian and post-apocalyptic novels offer dependent but distinct social imaginaries about the trajectory of post-industrial life. Where dystopian futurities typically project an intensification of technological surveillance, post-apocalyptic narratives often hinge on the fatal inability of institutions and networks to effectively manage threats posed by non-human forces, viruses, toxins, and climates. Pairing Charlie Booker’s “White Bear” episode of the TV series Black Mirror with Colson Whitehead’s novel Zone One, I analyse the pivotal instant when the genre of both of these texts suddenly changes: the dystopian becomes apocalyptic and vice versa. This moment of bewilderment, I argue, is a symptom produced by a generic engine that represents future catastrophes as alibis for more exacting forms of dystopian control, and represents dystopian control as precipitating ever more catastrophic catastrophes.
Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome

The purpose of this article is to describe the prevalence of cardiac disease previously undiagnosed in healthy asymptomatic children and adolescents with Down syndrome (DS). Subjects with DS ages 10-20 years were recruited from two sites, the Children's Hospital of Philadelphia (Philadelphia, PA) and Children's National Health System (Washington, DC) for a cross-sectional study of body composition and cardiometabolic risk. Echocardiographic and clinical data were collected from patients enrolled in the parent study of cardiometabolic risk. Nine (6%) new cardiac diagnoses were identified out of 149 eligible patients. All new findings resulted in outpatient referrals to pediatric cardiology. Current guidelines recommend screening all newborns with DS for congenital heart disease. Older patients with DS may benefit from rescreening.
169 Yb-based rotating shield brachytherapy for prostate cancer.

Purpose To present a system for the treatment of prostate cancer in a single-fraction regimen using 169 Yb-based rotating shield brachytherapy (RSBT) with a single-catheter robotic delivery system. The proposed system is innovative because it can deliver RSBT through multiple implanted needles independently, in serial, using flexible catheters, with no inter-needle shielding effects and without the need to rotate multiple shielded catheters inside the needles simultaneously, resulting in a simple, mechanically robust, delivery approach. RSBT was compared to conventional 192 Ir-based high-dose-rate brachytherapy (HDR-BT) in a treatment planning study with dose escalation and urethral sparing goals, representing single-fraction brachytherapy monotherapy and brachytherapy as a boost to external beam radiotherapy, respectively. A prototype mechanical delivery system was constructed and quantitatively evaluated as a proof of concept. Methods Treatment plans for twenty-six patients with single fraction prescriptions of 20.5 and 15 Gy, were created for dose escalation and urethral sparing, respectively. The RSBT and HDR-BT delivery systems were modeled with one partially shielded 999 GBq (27 Ci) 169 Yb source and one 370 GBq (10 Ci) 192 Ir source, respectively. A prototype angular drive system for helical source delivery was constructed. Mechanical accuracy measurements of source translational position and angular orientation in a simulated treatment delivery setup were obtained using the prototype system. Results For dose escalation, with equivalent urethra D10% , PTV D90% for RSBT vs HDR-BT increased from 22.6 ± 0.0 Gy (average ± standard deviation) to 29.3 ± 0.9 Gy, or 29.9 % ± 3.0%, with treatment times of 51.4 ± 6.1 min for RSBT and 15.8 ± 2.3 min for 10 Ci 192 Ir-based HDR-BT. For urethra sparing, with equivalent PTV D90 % , urethra D10% for RSBT vs HDR-BT decreased for RSBT vs HDR-BT from 15.6 ± 0.4 Gy to 12.0 ± 0.4 Gy, or 23.1% ± 3.5%, with treatment times of 30.0 ± 3.7 min for RSBT and 12.3 ± 1.8 min for HDR-BT. Differences between measured vs predicted rotating catheter positions (corresponding to source position) were within 0.18 mm ± 0.12 mm longitudinally and 0.07° ± 0.78°. Conclusion 169 Yb-based RSBT can increase PTV D90% or decrease urethral D10% relative to HDR-BT with treatment times of less than 1 h using a single-source robotic delivery system with treatment delivered in a single fraction. The prototype helical delivery system was able to demonstrate adequate mechanical accuracy.
Abstract 16661: Fluid Challenge During Right Heart Catheterization for Evaluation of Pulmonary Hypertension Identifies Patients With Decreased Right Ventricular Function

Introduction: Fluid challenge during right heart catheterization (RHC) identifies occult left heart diastolic dysfunction (Occ-DD) in 10-20% of patients initially diagnosed with pre-capillary pulmo...
Short report: Development and utility of the Family-Centered Autism Navigation interview

Navigating various systems, resources, and supports available for families of children with autism spectrum disorder is challenging. Family navigation is a potentially important support system for ...
Pediatric Unilateral Vocal Fold Paralysis: Workup and Management

This paper will examine recent advances in the assessment and management of pediatric unilateral vocal fold motion impairment (VFMI). Unilateral VFMI can have a considerable impact on pediatric voice, swallowing, and pulmonary hygiene. In addition, postoperative VFMI in children undergoing congenital cardiac procedures is associated with longer lengths of stay. Laryngeal ultrasound (LUS) is an adjunctive tool that can be used to assess vocal fold mobility in patients who cannot tolerate traditional flexible nasolaryngoscopy (FNL) or for those in whom FNL is non-diagnostic. Laryngeal electromyography (LEMG) can help differentiate neuronal causes of vocal fold paralysis from mechanical cricoarytenoid joint fixation. Recent data suggests that preoperative LEMG may be used to predict voice outcomes after non-selective laryngeal reinnervation (NSLR). NSLR is a promising treatment modality for permanent vocal fold medialization in children. An emphasis on early diagnostic and prognostic techniques, such as the use of LUS and LEMG, can inform decision-making in unilateral VFMI treatment. NSLR is emerging as the preferred treatment modality for pediatric unilateral VFMI due to neuronal injury.
Prolactin and Other Pituitary Disorders in Kidney Disease

Prolactin levels are increased in chronic kidney disease (CKD) as a result of reduced clearance and increased secretion. Hyperprolactinemia manifests as galactorrhea and hypogonadism. Treatment of hyperprolactinemia should focus on improving bothersome galactorrhea or hypogonadism by using dopamine agonists and/or replacement of sex hormone(s). Changes in the hypothalamic-pituitary-adrenal axis in CKD are characterized by increases in adrenocorticotropic hormone (ACTH) and cortisol levels, largely preserved circadian rhythms of ACTH and cortisol, and a normal response of cortisol to ACTH, metyrapone, and insulin-induced hypoglycemia. However, the hypothalamic-pituitary-adrenal axis is less inhibited by 1 mg dexamethasone but retains normal suppression by higher-dose dexamethasone. Diagnosis of adrenal insufficiency in CKD patients, as in normal subjects, usually is made by finding a subnormal cortisol response to ACTH. The mainstay of treatment of adrenal insufficiency is to replace glucocorticoid hormone. Cushing's disease in CKD is difficult to diagnose and relies on the dexamethasone suppression test and the midnight salivary cortisol test because the 24-hour urine free cortisol test is not useful because it is increased already in CKD. Treatment of Cushing's disease involves surgery, complemented by radiation and/or medical therapy if necessary. Growth hormone levels are increased and insulin-like growth factor 1 levels are normal in patients with CKD. In a normal patient with CKD, as in one with acromegaly, there can be a paradoxic increase in growth hormone after an oral glucose load. Therefore, diagnosis of acromegaly in renal insufficiency is challenging. The treatment of choice for acromegaly is surgery, although data for medical treatment for acromegaly in CKD are rare. In patients with renal impairment, arginine vasopressin levels are increased as a result of decreased clearance, and there also is impairment of arginine vasopressin signaling in renal tubules. Diabetes insipidus can be masked in advanced kidney disease until kidney transplantation. Diagnosis of the syndrome of inappropriate antidiuretic hormone is similar in mild or moderate kidney disease as in normal subjects, but is challenging in patients with advanced kidney disease owing to the impairment in urine dilution.