cssi/SciSciGPT-SciSciNet huggingface dataset:
The Poetics of Devotion in ʿĀʾisha al‐Bāʿūniyya's Praise of God and Muḥammad

Recently, there has been an effort within Islamic Studies to reassess the common belief that the so-called ‘post-classical’ era of Islamic history was characterized by intellectual stagnation and decline. The Mamluk era is one such period that has suffered from a dearth of scholarly attention resulting from outdated stereotypes. This article contributes to scholarship on this era through examining some poems by a late Mamluk poet, ʿĀʾisha al-Bāʿūniyya (d. 1517). While much scholarship on al-Bāʿūniyya focuses on her lyrical mystical verse, the poems studied here incorporate selective allusions to key Islamic sources in order to narrate a history of divine favor as the speaker imagines it. This innovative history expresses a poetics of devotion that focalizes Muḥammad and the poet's own peers. The poems intertextually anchor this narrative in key Islamic sources, reflecting al-Bāʿūniyya's extensive scholarly training. They constitute an unusual example of a female poet writing beyond the genres with which women's premodern poetry is conventionally associated. This poetry also represents a post-classical contribution to Islamic literary and religious history. However, the criterion of originality should ultimately be reconsidered in evaluations of scholarly merit, and scholarship should pay more attention to continuities and intertextuality in texts.
Introduction: Robert F. Wagner, the Forgotten Mayor

Both the public and academics have largely forgotten three-term mayor Robert F. Wagner (1954–1965). However, his administration institutionalized New York liberalism and created the modern political system. Robert Wagner was one of the most influential mayors in the city’s history.
Application of modulus degradation model of clays.

A degradation model is applied in conjunction with different soil models and stress-strain relations to site response analyses during earthquakes. To evaluate the effects of degradation, computations on two clay deposits subjected to both high and low-level input excitations are conducted. In addition, modulus degradation with or without shear strength reduction is discussed. In terms of surface response, degradation has little effect in the case of low-level excitation. With high-level excitatfons, however, degradation causes lower surface spectral response in the shorter period range, and the difference is on the same order as that from different soil models. Where surface response differs, the use of degradation with strength reduction is less conservative when compared to the use of degradation without strength reduction.
Precise Localization of Homes and Activities: Detecting Drinking-While-Tweeting Patterns in Communities

There has been an explosion of research on analyzing social media to map human behavior relevant to public health, such as drinking or drug use. However, it is important not only to detect the local regions where these activities occur, but also to analyze the degree of participation in them by local residents. We develop powerful new methods for fine-grained localization of activities and home locations using Twitter data. We apply these methods to discover and compare alcohol use patterns in a large city, New York City, and a more suburban and rural area, Monroe County.
Diet, Alcohol Use, and Colorectal Cancer Screening among Black Church-goers.

Objectives Interventions for colorectal cancer (CRC) prevention among black adults are needed. Connections between CRC screening non-adherence and other health risk behaviors may inform intervention development. Methods Associations between red meat (RM) and fruit and vegetable (FV) consumption, at-risk alcohol use, and CRC ever-screening were examined using adjusted logistic regressions among 520 church-going black adults in Houston, Texas, aged >50. Results In the final adjusted model, being younger, uninsured, eating more RM and engaging in at-risk alcohol use were associated with lower likelihood of CRC ever-screening. Conclusions Church-based interventions to increase CRC screening among black adults might capitalize on associations with RM consumption and alcohol use behaviors as part of a broader wellness promotion initiative.
Stuttering Frequency in Relation to Lexical Diversity, Syntactic Complexity, and Utterance Length:

Children’s frequency of stuttering can be affected by utterance length, syntactic complexity, and lexical content of language. Using a unique small-scale within-subjects design, this study explored whether language samples that contain more stuttering have (a) longer, (b) syntactically more complex, and (c) lexically more diverse utterances than samples that contain less stuttering. Children who stutter, ages 2 years 1 month to 4 years 11 months, produced 10 monthly language samples. For each child, samples were divided into the first five (early) and the last five (later). Utterance length, syntactic complexity, and lexical diversity analyses were performed on samples that contained the most and least stuttering for early and later samples. For the later samples but not the early ones, samples with the most stuttering contained longer mean lengths of utterance, more diverse vocabulary overall, and greater syntactic complexity than samples with the least stuttering. Contributions of language growth, time,...
North America and Native Americans: Sociocultural Aspects

An overview of Native Americans north of Mexico is provided, including characteristics of Native American societies and cultures, aspects of Native American history—government policies aimed at assimilating Native Americans—and the contemporary situation of Native Americans in the United States and Canada. Particular attention is given to Native American origins, aboriginal population size, population decline following the arrival of Columbus, and recent population recovery. The study of Native Americans is also considered, as it was important in the development of anthropology in North America and elsewhere.
Near-glacier surveying of a subglacial discharge plume: implications for plume parameterizations†

At tidewater glaciers, plume dynamics affect submarine melting, fjord circulation, and the mixing of meltwater. Models often rely on buoyant plume theory to parameterize plumes and submarine melting; however, these parameterizations are largely untested due to a dearth of near-glacier measurements. Here, we present a high-resolution ocean survey by ship and remotely-operated boat near the terminus of Kangerlussuup Sermia in west Greenland. These novel observations reveal the 3D structure and transport of a near-surface plume, originating at a large undercut conduit in the glacier terminus, that is inconsistent with axisymmetric plume theory, the most common representation of plumes in ocean-glacier models. Instead, the observations suggest a wider upwelling plume – a ‘truncated’ line plume of ∼200 m width – with higher entrainment and plume-driven melt compared to the typical axisymmetric representation. Our results highlight the importance of a subglacial outlet's geometry in controlling plume dynamics, with implications for parameterizing the exchange flow and submarine melt in glacial fjord models.
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

Half of all prostate cancers are caused by the TMPRSS2-ERG gene-fusion, which enables androgens to drive expression of the normally silent E26 transformation-specific (ETS) transcription factor ERG in prostate cells. Recent genomic landscape studies of such cancers have reported recurrent point mutations and focal deletions of another ETS member, the ETS2 repressor factor ERF. Here we show these ERF mutations cause decreased protein stability and mostly occur in tumours without ERG upregulation. ERF loss recapitulates the morphological and phenotypic features of ERG gain in normal mouse prostate cells, including expansion of the androgen receptor transcriptional repertoire, and ERF has tumour suppressor activity in the same genetic background of Pten loss that yields oncogenic activity by ERG. In the more common scenario of ERG upregulation, chromatin immunoprecipitation followed by sequencing indicates that ERG inhibits the ability of ERF to bind DNA at consensus ETS sites both in normal and in cancerous prostate cells. Consistent with a competition model, ERF overexpression blocks ERG-dependent tumour growth, and ERF loss rescues TMPRSS2-ERG-positive prostate cancer cells from ERG dependency. Collectively, these data provide evidence that the oncogenicity of ERG is mediated, in part, by competition with ERF and they raise the larger question of whether other gain-of-function oncogenic transcription factors might also inactivate endogenous tumour suppressors.
Abstract 4121: Androgen receptor as a potential target in non-small cell lung cancer

The cancer genome atlas (TCGA) has identified androgen receptor (AR) to be mutated, deleted and amplified across human lung squamous cell carcinoma and adenocarcinoma. Expression of AR is critical for early lung development. However, the intriguing expression of AR in non-small cell lung cancer (NSCLC) opens up an alternative treatment paradigm in the event of onset of clinical resistance to lung cancer drugs. To investigate this potential, a) 10 NSCLC cell lines and 3 control prostate cancer cell lines were stimulated with synthetic AR agonist, R1881 at 24, 48 and 72 hours. 0.5-4-fold RNA and protein expression was found across these lung cancer cell lines when compared to unstimulated cells. b) droplet digital PCR revealed varying copies of AR DNA when benchmarked to prostate AR. c) cell proliferation assays of these cell lines with enzalutamide (MVD3100) treatment resulted in 50-65% cell survival at concentrations ranging from 10 - 25 µM. d) Immunohistochemical staining of AR in a NSCLC human tissue microarray (TMA) revealed 10 out of 88 patients (11%) to have AR positive staining in their tumor. This included 6 adenocarcinomas and 2 squamous cell carcinomas. 8 patients had focal while 2 had diffuse staining. Validation of the TMA performed with whole mount slides confirmed diffuse staining in these 11 samples. Taken together, these findings suggest AR is a potential therapeutic target in NSCLC and further work is underway to test these observations in drug resistant lung cancer cell lines and pre-clinical mouse models. Citation Format: Sean Brennan, Albert R. Wang, Hope Beyer, Dylan Wiese, Darya Buehler, Anwaar Saeed, Andrew M. Baschnagel, Gopal Iyer. Androgen receptor as a potential target in non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4121. doi:10.1158/1538-7445.AM2017-4121
Angiotensin II Type 1 receptor antibodies are associated with inflammatory cytokines and poor clinical outcomes in pediatric kidney transplantation.

Angiotensin II type 1 receptor (AT1R) antibody has been linked to poor allograft outcomes in adult kidney transplantation. However, its clinical consequences in children are unknown. To study this, we examined the relationship of AT1R antibody with clinical outcomes, biopsy findings, inflammatory cytokines, and HLA donor-specific antibodies (DSA) in a cohort of pediatric renal transplant recipients. Sixty-five patients were longitudinally monitored for AT1R antibody, HLA DSA, IL-8, TNF-α, IL-1β, IFN-γ, IL-17, and IL-6, renal dysfunction, hypertension, rejection, and allograft loss during the first two years post transplantation. AT1R antibody was positive in 38 of the 65 of children but was not associated with HLA DSA. AT1R antibody was associated with renal allograft loss (odds ratio of 13.1 [95% confidence interval 1.48–1728]), the presence of glomerulitis or arteritis, and significantly higher TNF-α, IL-1β, and IL-8 levels, but not rejection or hypertension. AT1R antibody was associated with significantly greater declines in eGFR in patients both with and without rejection. Furthermore, in patients without rejection, AT1R antibody was a significant risk factor for worsening eGFR over the two-year follow-up period. Thus, AT1R antibody is associated with vascular inflammation in the allograft, progressive decline in eGFR, and allograft loss. AT1R antibody and inflammatory cytokines may identify those at risk for renal vascular inflammation and lead to early biopsy and intervention in pediatric kidney transplantation.
Modeling Dynamic Transcriptional Circuits with CRISPRi

Targeted transcriptional repression with catalytically inactive Cas9 (CRISPRi) can be used to build gene regulatory nets similar in principle to those made with traditional transcription factors, and promises to do so with better orthogonality, programmability, and extensibility. We use a simple dynamical model of CRISPRi to understand its behavior and requirements, and to show that CRISPRi can recapitulate several classic gene regulatory circuits, including the repressilator, a toggle switch, and an incoherent feed-forward loop pulse generator. Our model also predicts that these circuits are highly sensitive to promoter leak, but that promoter leak can be offset with active degradation of dCas. We provide specifications for required fold-repression and dCas degradation rates for several dynamic circuits. Our modeling reveals key engineering requirements and considerations for the construction of dynamic CRISPRi circuits, and provides a roadmap for building those circuits.
Foreign Body Ingestions: Approach to Management

This article reviews the diagnosis, evaluation, pre-intervention preparation, and endoscopic management of pediatric foreign body ingestion, which is a commonly encountered problem that may present a challenge for healthcare providers and has a potential for significant morbidity and mortality. While the lack of randomized controlled trials in this area remains, recent literature has shed light on new imaging methods to localize foreign bodies and evaluate for complications, new types of foreign body ingestions, and updated management paradigms. Pediatric foreign body ingestions should be treated as emergencies. If clinically indicated, endoscopy has been shown to be safe, successful, and cost-effective with low rates of complication. Management depends on the size, location, and type of foreign body ingested. Development of clinical pathways for management of foreign body ingestion can be a useful tool for this patient population.
Genome-wide map of proximity linkage to renin proximal promoter in rat.

A challenge to understanding enhancer-gene relationships is that enhancers are not always sequentially close to the gene they regulate. Physical proximity mapping through sequencing can provide an ...
Methodological strategies in child clinical trials: advancing the efficacy and effectiveness of psychosocial treatments.

The present paper reviews issues of treatment efficacy (i.e., potency) and effectiveness (i.e., clinical utility) in applied clinical child research. Threats to treatment evaluation are reviewed in the context of these two dimensions. It is proposed that treatment outcome research faces new challenges stemming from the ever increasing emphasis on generalization of gains and dissemination of interventions outside of clinical research settings. Issues and approaches proposed as warranting further development and attention include development, flexibility, acceptability, and disseminability of psychosocial assessment and treatment methods. A research emphasis is promoted that balances experimental control with the need for treatment generalization and delivery outside of the research setting, in order to maximize the utility of clinical research.
Lectin-Conjugated Liposomes as Biocompatible, Bioadhesive Drug Carriers for the Management of Oral Ulcerative Lesions

Oral ulcerative lesions are painful and debilitating, particularly for immunosuppressed patients undergoing chemotherapeutic/irradiation treatment. Their clinical management requires multiple drugs to be administered simultaneously. Current formulations available to patients require frequent dosing, leading to poor compliance and suboptimal clinical outcomes. In this study, we prepared wheat germ agglutinin (WGA)-conjugated liposomes (WGA liposomes) to serve as bioadhesive drug carriers that can encapsulate various classes of drugs, rapidly bind to oral epithelial cells within minutes, and stay on the cells to provide sustained, localized drug release for days. Fluorescence binding studies found a significant increase (p < 0.05) in the binding of WGA liposomes to oral cells in as short an incubation time as 1 min compared to that for nonconjugated liposomes. WGA liposomes encapsulating model drug amoxicillin showed sustained in vitro drug release, and the released drugs provided potent antimicrobial activ...
How do IRS Resources Affect the Corporate Audit Process

ABSTRACT This study investigates how Internal Revenue Service resources affect the IRS audit process for publicly traded corporations. Using confidential IRS audit data, we examine the effect of IR...
Human Immunodeficiency Virus Infection and Risk of Heart Failure Readmissions

Background Human Immunodeficiency Infection (HIV) is associated with increased risk for heart failure (HF). Outcomes of HF in people living with HIV (PLHIV) are unknown. We sought to identify the risk of HF readmissions (30 and 90 days) among PLHIV vs uninfected controls admitted with HF. Methods Using the 2016 national readmission database, we identified all patients (≥ 18 years) who were discharged alive with a primary diagnosis of HF (ICD10 I50.xx) with or without secondary diagnosis of HIV (ICD 10 Z21, B20, O98.7, or B97.35). Propensity score matching (PSM) was used to match PLHIV with controls (1:1) based on 45 patient characteristics (demographics, hospitalization characteristics, and comorbidities). Cox regression models were used to compare rates of HF readmission (primary ICD10 I50.xx) within 30 and 90 days after discharge from index HF hospitalization. Results A total of 312,264 patients with HF were identified, of whom 1,112 (0.4%) had HIV. After PSM, 1,112 PLHIV were matched with 1,112 uninfected controls. The standard mean difference for each variable was less than 10% post-matching. Overall, HF readmission rates were 11.2% and 19.2% at 30 and 90 days, respectively. The two groups (PLHIV and controls) were not different statistically with respect to all 45 covariates. Compared with controls, PLHIV had higher risk of HF readmission within 30 days (HR 1.45, 95% CI: 1.13-1.87, P=0.004) and 90 days (HR 1.41, 95% CI 1.16-1.71, P Conclusions In this propensity-matched national cohort of patients admitted with HF, patients with HIV appear to have increased risk of HF readmissions compared with uninfected controls at 30 days and 90 days.
Integrating Inpatient Electronic Consultations in Cardiology Fellowship.

Clinical consultations, both inpatient and outpatient, contribute significantly to cardiologists’ workload [(1)][1]. With an aging population, increasing prevalence of cardiovascular comorbidities, and the introduction of high-sensitivity cardiac troponin assays, cardiology consultation services
VETA: An Open-Source Matlab-Based Toolbox for the Collection and Analysis of Electromyography Combined With Transcranial Magnetic Stimulation

The combination of electromyography (EMG) and transcranial magnetic stimulation (TMS) offers a powerful non-invasive approach for investigating corticospinal excitability in both humans and animals. Acquiring and analyzing the data produced with this combination of tools requires overcoming multiple technical hurdles. Due in part to these technical hurdles, the field lacks standard routines for EMG data collection and analysis. This poses a problem for study replication and direct comparisons. Although software toolboxes already exist that perform either online EMG data visualization or offline analysis, there currently are no openly available toolboxes that flexibly perform both and also interface directly with peripheral EMG and TMS equipment. Here, we introduce Visualize EMG TMS Analyze (VETA), a MATLAB-based toolbox that supports simultaneous EMG data collection and visualization as well as automated offline processing and is specially tailored for use with motor TMS. The VETA toolbox enables the simultaneous recording of EMG, timed administration of TMS, and presentation of behavioral stimuli from a single computer. These tools also provide a streamlined analysis pipeline with interactive data visualization. Finally, VETA offers a standard EMG data format to facilitate data sharing and open science.
Invertebrate Community Associated with the Asexual Generation of Bassettia pallida Ashmead (Hymenoptera: Cynipidae)

Abstract Cynipid gall wasps play an important role in structuring oak invertebrate communities. Wasps in the Cynipini tribe typically lay their eggs in oaks (Quercus L.), and induce the formation of a “gall”, which is a tumor-like growth of plant material that surrounds the developing wasp. As the wasp develops, the cynipid and its gall are attacked by a diverse community of natural enemies, including parasitoids, hyperparasitoids, and inquilines. Determining what structures these species-rich natural enemy communities across cynipid gall wasp species is a major question in gall wasp biology. Additionally, gall wasps are ecosystem engineers, as the abandoned gall is used by other invertebrates. The gall-associated insect communities residing on live oaks (Quercus geminata Small and Q. virginiana Mill.) are emerging as a model system for answering ecological and evolutionary questions ranging from community ecology to the evolution of new species. Documenting the invertebrates associated with cynipids in this system will expand our understanding of the mechanisms influencing eco-evolutionary processes, record underexplored axes of biodiversity, and facilitate future work. Here, we present the community of natural enemies and other associates of the asexual generation of the crypt gall wasp, Bassettia pallida Ashmead. We compare the composition of this community to communities recently documented from two other cynipid gall wasps specializing on live oaks along the U.S. Gulf coast, Disholcaspis quercusvirens Ashmead and Belonocnema treatae Mayr. B. pallida and their crypts support a diverse arthropod community, including over 25 parasitoids, inquilines, and other associated invertebrates spanning 5 orders and 16 families.
Steven MacGregor Demorest (1959-2019)

Steven Demorest, as both a scholar and a singer, had a voice that was strong and resonant. Steve’s passion for singing grew as an undergraduate in the Luther College choirs under the inspiring direction of Weston Noble, as a graduate student at Westminster Choir College, and through his doctoral work at the University of Wisconsin, where he encountered the choral artistry of Robert Fountain. His value for and pursuit of rigorous research and musical accomplishment—pairing the two while maintaining the integrity of each—characterized his contribution to the fields of choral music, music education, and music psychology. Rather than viewing musical excellence as exclusive, Steve saw musical achievement as something everyone could and should experience. He also believed that those responsible for guiding such experiences should be skilled as musicians and as teachers. Through a career that began at the University of North Texas, then at the University of Washington, and finally at Northwestern University, Steve worked tirelessly to bring about the best in music-making …
Diplomacy and signaling

C ommunication is an important aspect of international relations. While diplomacy goes back to antiquity, the institution of diplomacy as we know it was developed during the Italian Renaissance to facilitate communication between states (Nicolson 1954). We have already seen how private information can lead to conflict, and we, therefore, have a convincing rationale for how communication could prevent conflict. This chapter will introduce the topic of communication in international relations. First, I will discuss a class of models in which the communication is costless, so it is designed to represent ordinary verbal communication such as diplomacy in which the parties may lie if it suits their interests with no direct penalty, other than what the strategic situation they are in provides. These models are denoted “cheap talk” models in economics. We will see that there are limits to the effectiveness of cheap talk in dealing with situations in which the players have conflicting interests. In some cases, therefore, states resort to “costly signals”, in which the means of communication have direct costs attached. Examples include threats that invoke a state or leader's reputation or domestic job security and mobilization of military power and engaging in actions that generate a risk of war. Communication in international relations The study of communication and signaling in international relations has a long history. An eighteenth-century French diplomat, Francois de Callieres, wrote a treatise on diplomacy that continues to be read today (de Callieres 1994). International relations as a discipline grew out of the study of diplomatic history and international law (Nicolson, 1939). Influential works in the field focused heavily on diplomatic maneuverings and included case studies of important diplomatic conferences such as the Congress of Vienna that followed the Napoleonic wars (Taylor 1954, Kissinger 1954). Schelling pioneered the analysis of communication in the context of international bargaining with a particular focus on how to make threats and commitments credible to adversaries when they might have reason to doubt that a state would fulfill them (Schelling 1960, 1966).
Energy-harvesting bioreactors: toward self-powered microfluidic devices, a mini-review

The past decades have witnessed tremendous progress in microfluidics in terms of functionalities and applications. To realize various functions such as actuation and sensing, a source of energy is often needed. Batteries, as a common energy source for portable devices, are not always preferred in situations such as remote sensing and in vivo applications. Nature has provided us with microorganisms and biomolecules capable of converting biomass into useful form of energy via complex chemical pathways. It would be extremely useful if microdevices can be self-powered by consuming “foods” around them. Recently, various types of microfluidic bioreactors have been developed to harness energy by intending to replicate natural processes. Most of them were used to generate electricity in a biofuel cell configuration. Others were used to produce mechanical actuation based on processes such as fermentation. Here, we summarize recent progresses made in this area. Specifically, we compare various applications and their performance metrics. We also discuss critical problems in this technology and highlight future opportunities for self-powered microfluidics.
Biophysical and Biochemical Characterization of TP0037, a d-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum.

A longstanding conundrum in Treponema pallidum biology concerns how the spirochete generates sufficient energy to fulfill its complex pathogenesis processes during human syphilitic infection. For decades, it has been assumed that the bacterium relies solely on glucose catabolism (via glycolysis) for generation of its ATP. However, the organism's robust motility, believed to be essential for human tissue invasion and dissemination, would require abundant ATP likely not provided by the parsimony of glycolysis. As such, additional ATP generation, either via a chemiosmotic gradient, substrate-level phosphorylation, or both, likely exists in T. pallidum Along these lines, we have hypothesized that T. pallidum exploits an acetogenic energy conservation pathway that relies on the redox chemistry of flavins. Central to this hypothesis is the apparent existence in T. pallidum of an acetogenic pathway for the conversion of d-lactate to acetate. Herein we have characterized the structural, biophysical, and biochemical properties of the first enzyme (d-lactate dehydrogenase [d-LDH]; TP0037) predicted in this pathway. Binding and enzymatic studies showed that recombinant TP0037 consumed d-lactate and NAD+ to produce pyruvate and NADH. The crystal structure of TP0037 revealed a fold similar to that of other d-acid dehydrogenases; residues in the cofactor-binding and active sites were homologous to those of other known d-LDHs. The crystal structure and solution biophysical experiments revealed the protein's propensity to dimerize, akin to other d-LDHs. This study is the first to elucidate the enzymatic properties of T. pallidum's d-LDH, thereby providing new compelling evidence for a flavin-dependent acetogenic energy conservation (ATP-generating) pathway in T. pallidum IMPORTANCE Because T. pallidum lacks a Krebs cycle and the capability for oxidative phosphorylation, historically it has been difficult to reconcile how the syphilis spirochete generates sufficient ATP to fulfill its energy needs, particularly for its robust motility, solely from glycolysis. We have postulated the existence in T. pallidum of a flavin-dependent acetogenic energy conservation pathway that would generate additional ATP for T. pallidum bioenergetics. In the proposed acetogenic pathway, first d-lactate would be converted to pyruvate. Pyruvate would then be metabolized to acetate in three additional steps, with ATP being generated via substrate-level phosphorylation. This study provides structural, biochemical, and biophysical evidence for the first T. pallidum enzyme in the pathway (TP0037; d-lactate dehydrogenase) requisite for the conversion of d-lactate to pyruvate. The findings represent the first experimental evidence to support a role for an acetogenic energy conservation pathway that would contribute to nonglycolytic ATP production in T. pallidum.
Perspectives on the benefits of leadership training for career growth among three mid-career behavioral scientists

Participation in the Society of Behavioral Medicine (SBM) Mid-Career Leadership Institute was invaluable in navigating challenges and opportunities experienced by behavioral scientists at key mid-career transitions. Professionals are expected to take on more responsibilities at mid-career, often with minimal guidance and/or relevant training in the requisite leadership skills. The SBM Leadership Institute provided concrete practical strategies for managing time, work email, planning/goal setting, and conflict resolution. The purpose of this commentary is to review the impact of the SBM Leadership Institute on new leadership roles obtained by three SBM Leadership Fellows. Practices adopted as a result of the Leadership Institute will be discussed (e.g., right sizing the workload, "inbox zero," starting with priority work, and single tasking). The use of these strategies resulted in increased productivity and reduced work stress. Furthermore, one-on-one executive career coaching and participation in our learning community cultivated the direct, effective communication skills needed to take on new leadership roles/projects (e.g., transitioning to department chair, running for SBM board, launching ACSM Exercise is Medicine On Campus program). The leadership projects helped to push Fellows out of their comfort zones and provided excellent opportunities for networking and increased involvement in organizations and professional societies. In sum, the SBM Leadership Institute helped instill the confidence and focus needed to surmount midcareer obstacles and accelerate into the next career phase.
Effect of fracture orientation on ultrasonic wave signatures

Fluid flow through low-permeable rock masses is dominated by transport through discontinuities such as fractures, faults, and joints present in the rock. These discontinuities are beneficial for some geo-resources such as geothermal, oil and gas reservoir, but detrimental for other applications such as CO2 storage and hazardous waste isolation. Fracture orientation plays a critical role during the design of the geo-resources. Often times, ultrasonic waves are used in the field to locate and characterize the fractures. In this study, the effect of fracture orientation (0° to 90°) on ultrasonic wave signatures was investigated by conducting a series of experiments on a granite rock with a longitudinal fracture under confining pressures of 15, 30, and 45 MPa. Ultrasonic wave signatures during the experiment were collected using the ultrasonic transducers embedded in the core holders that were attached to the two ends of the specimen. Results indicated sensitivity of the ultrasonic wave velocities, waveforms, and amplitudes (cross-polarized S-waves) to the fracture orientation.
Impacts on knowledge and testing on HIV in waves of Mozambique surveys with Bayes estimates

Background It is well known that it is more reliable to investigate the effects of several covariates simultaneously rather than one at time. Similarly, it is more informative to model responses simultaneously, as more often than not, the multiple responses from the same subject are correlated. This is particularly true in the analysis of Mozambique survey data from 2009 and 2018. Method A multiple response predictive model for testing positive for HIV and having sufficient HIV knowledge is modeled to 2009 and 2018 survey data with the use of Bayes estimates. These data are obtained through a hierarchical data structure. The model allows one to address the change in the response to HIV, as it relates to morbidity and to HIV knowledge in Mozambique in the fight against the disease in the last decade. Results A more affluent resident is more likely to test positive, more likely to be more knowledgeable about the disease. Whereas, individuals practicing the Islam faith are less likely to test positive but also less likely to be knowledgeable about the disease. Education, while still a factor, has declined in its impact on testing positive for HIV or being knowledgeable about HIV. Females are more likely to test positive but more likely to be knowledgeable about the disease than men. The rate of impact of affluence on knowledge has increased in the past decade. Marital status (cohabitating or married) showed no impact on the knowledge of the disease. Age had no impact on knowledge suggesting that the message is getting to resident. Conclusions A joint Bayes modeling of correlated binary (testing positive and knowledge about the disease) responses, while accounting for the hierarchy of the data collection, presents an opportunity to extract the extra variation before allocating the variation on the responses as the due of the covariates. The fight against HIV in Mozambique seems to be succeeding. Some knowledge is common among all ages, and Islam religion has a positive effect. While education still shows an influence on the binary responses, it has declined over the last decade.
A novel tumor-immune microenvironment (TIME)-on-Chip mimics three dimensional neutrophil-tumor dynamics and neutrophil extracellalar traps (NETs)- mediated collective tumor invasion.

Neutrophils are the most abundant type of leukocytes in the blood, traditionally regarded as the first immune responders to infections and inflammations. In the context of tumors, neutrophils have been shown to possess both tumor-promoting and tumor-limiting properties. A better understanding of the inter-cellular dynamics between the neutrophils and aggregated tumors could possibly shed light on the different modalities of neutrophil involvement in tumor progression. To study in-vitro the interactional dynamics of neutrophils and growing tumor aggregates, in this work, we engineered a novel, microfluidics-integrated, three-dimensional (3D) Tumor-Immune Microenvironment (TIME)-on-Chip device, and we investigated the effect of neutrophils on the inception of collective 3D invasion of ovarian tumor cells. Herein, tumor spheroids generated and cultured on hydrogel based multi-microwell plates, and embedded within collagen matrix of defined thickness, were magnetically hybrid-integrated with a 3D bioprinting enabled microfluidic system fabricated on a porous membrane and carrying neutrophils. This setting recreated a typical TIME in-vitro to model dynamic neutrophil migration and 3D tumor invasion. Using this device, we observed that neutrophils respond to the growing tumor spheroids through both chemotaxis and generation of Neutrophil Extracellular Traps (NETs). The formation of NETs stimulated the reciprocation of tumor cells from their aggregated state to collectively invade into the surrounding collagen matrix, in a manner more significant compared to their response to known tumor-derived stimulants such as TGF-β and IL-8. This effect was reversed by drug-induced inhibition of NETs formation, suggesting that induction of NETs by cancer cells could be a pro-migratory tumor behavior. Further, we additionally report a previously unidentified, location-dictated mechanism of NETosis, in which NETs formation within the stromal extracellular collagen matrix around the spheroids, and not tumor-contacted NETs, is important for the induction of collective invasion of the ovarian tumor cells, thus providing a rationale for new anti-tumor therapeutics research.
Escaping The Sisyphean Trap: How Quants Can Achieve Their Full Potential (Seminar Slides)

Investing can be characterized as a data science problem. While investment firms have attracted scientific talent, they have done a poor job at developing it. Firms hire specialists, but entice them to become generalists (e.g., portfolio managers). Under the ubiquitous silo/platform structure, quants succumb to the Sisyphean trap, and do not achieve their full potential. A research lab structure offers a unique environment for developing scientists, by means of: (a) co-specialization, working in a highly cooperative lab environment; (b) tackling well-defined open investment problems; and (c) applying the scientific method.
Improving Student Learning While Converting a Computer Architecture Course to Online Format

A required Computer Architecture course for Computer Science majors was converted to online form in Spring 2011. In this paper we discuss the changes made to make the course successful online, especially in content preparation, course organization, and the construction and handling of assignments. We discuss why we feel the revised course produces improved student learning in terms of the basic principles of scaffolding, self-explanation and multimodal learning. We also discuss how we made the course practical to administer on an ongoing basis. We hope that this experience will be helpful to other faculty members planning to convert courses in Computer Science or Engineering to an online format.
Delivering an Experiential Emersion Course to Enhance MBA Retention Rates, Achieve Understanding and Support for Institutional Missions and Values, and Hone Practical Skills in Applied Leadership

This article shares our experiences at Seattle University with a 16-year-old program that dramatically raises MBA student retention rates, conveys and achieves alignment with institutional values and mission goals, and develops interpersonal leadership skills that immediately enhance our students’ effectiveness in their current work lives. Legacy benefits include an estimated $16.2 million in incremental tuition revenues over this 16-year period, with no offsetting incremental expenses, and 16 years of loyal MBA alumni who identify emotionally with both our university, with our business school, and with their many fellow alumni with whom they otherwise would not have developed a collegial connection.
12-23 GHz ultra wide tuning range voltage-controlled ring oscillator with hybrid control schemes

This paper presents the design of a voltage-controlled ring oscillator that has ultra wide tuning range of 12 to 23 GHz with hybrid control schemes. The voltage-controlled oscillator (VCO) uses a feedforward interpolation topology scheme and a varactor diode load capacitance variation scheme to control the oscillation. The measurement result of the VCO shows good linearity in frequency-voltage characteristics over the ultra wide tuning range.
Parallel Architectures For Iterative Image Restoration

The recovery or restoration of an image that has been distorted is one of the most important problems in image processing applications. A number of algorithms or filters providing a solution to the image restoration problem, have appeared in the literature. Iterative restoration algorithms are used and analyzed in this work, due to advantages they offer over other existing techniques. Such algorithms, however, are generally computationally extensive and time consuming, as is the case with most image processing tasks. Therefore, there has been a natural interest in improving the response times of the image processors to extend the horizon of their applicability.
Eight polymorphic microsatellite loci for a Neotropical nutmeg, Virola flexuosa (Myristicaceae)

Eight highly polymorphic microsatellite loci were developed for Virola flexuosa from a (CA) n enriched genomic library for population and seed dispersal studies in eastern Ecuador. Loci show a high level of variation with the number of alleles ranging from 13 to 27. Observed and expected heterozygosities were from 0.313 to 0.896 and 0.552 to 0.937, respectively. The high levels of polymorphism and exclusionary power of the developed markers will likely prove very useful in direct measurement of seed dispersal.
CoVaC: Compiler Validation by Program Analysis of the Cross-Product

The paper presents a deductive framework for proving program equivalence and its application to automatic verification of transformations performed by optimizing compilers. To leverage existing program analysis techniques, we reduce the equivalence checking problem to analysis of one system --- a cross-product of the two input programs. We show how the approach can be effectively used for checking equivalence of consonant (i.e., structurally similar) programs. Finally, we report on the prototype tool that applies the developed methodology to verify that a compiler optimization run preserves the program semantics. Unlike existing frameworks, CoVaC accommodates absence of compiler annotations and handles most of the classical intraprocedural optimizations such as constant folding, reassociation, common subexpression elimination, code motion, dead code elimination, branch optimizations, and others.
The Cerebrocerebellar System

The cerebellum has massive reciprocal interconnections with the cerebral cortex and with cerebral subcortical structures that complement its interconnections with the spinal cord and brainstem. The major cerebrocerebellar link is mediated by the feedforward/afferent corticopontine projections and mossy fibers emanating from the pontocerebellar projections, and the feedback/efferent cerebellothalamic and thalamocortical projections. These highly arranged connections link sensorimotor, associative and limbic regions of cerebral cortex with the cerebellum and the intervening pontine nuclei and thalamus in a topographically precise manner. The cerebellum also has reciprocal links with the basal ganglia and hypothalamus, and with structures in the limbic circuit. In addition to these mossy fiber afferents to cerebellum, the inferior olive receives indirect input from motor and associative regions of the cerebral cortex by way of the red nucleus and zona incerta, and it conveys these inputs to cerebellum via climbing fibers. The cerebrocerebellar pathways are organized into segregated loops of information processing and stand in contrast to the cerebellar cortical architecture that is essentially uniform. Knowledge of cerebrocerebellar circuits is critical to understanding theories of the cerebellar contribution to motor and nonmotor function, and to the diagnosis and management of patients with lesions in these pathways.
Field Release of Genetically Engineered Microorganisms (GEM)

The Necessity for Field Release Trials Barriers to Field Release Studies Reducing Risks During Field Release Trials Keywords: environmental release of microorganisms; genetically engineered microorganisms (GEMs); polymerase chain reaction (PCR); risk assessment
Top Quark Physics at the Tevatron

We discuss physics of the top quark at the Fermilab Tevatron. By the year 2000, many properties of the top quark can be measured at the Tevatron.
Adult Supervision Required: The Commonwealth of Massachusetts's Reckless Adventures with Affordable Housing and the Anti-Snob Zoning Act

Recognizing that municipalities are inherently selfish and that they would intentionally exclude certain land uses and structures, the majority of states have required that their cities and towns plan for and accommodate undesirable land uses within their borders. The planned incorporation of undesirable and desirable land uses is a fundamental attribute of states that require and enforce the preparation of coordinated and rationally developed comprehensive plans. This Article discusses the approach taken in Massachusetts—a non plan state—and its myopic and regressive mechanism for compelling the construction of affordable housing. The Article suggests that the Massachusetts example is a failure of law and policy and that the statute, both abusive and abused, must be repealed. In its stead, Massachusetts must look to the success of numerous other states that have incorporated the development of affordable housing—and other land uses—within a rationally developed, and legally meaningful, comprehensive plan.
FERTILIDAD Y EMBARAZO EN PACIENTES CON ENFERMEDADES INFLAMATORIAS INTESTINALES

RESUMEN Las Enfermedades Inflamatorias Intestinales (EII) son entidades cronicas del tracto digestivo, que afectan frecuentemente a pacientes en edad reproductiva. Debido a las caracteristicas de estas enfermedades y su tratamiento, existen multiples desafios. En este articulo, revisamos la evidencia mas reciente con respecto a fertilidad y embarazo en pacientes con EII. En general, existe evidencia de que pacientes con EII tienen una mayor tasa de complicaciones durante el embarazo con respecto a pacientes sin EII. Sin embargo, esta diferencia esta directamente asociada al grado de actividad de la enfermedad. La mayor parte de los farmacos hoy usados en el tratamiento de EII son considerados seguros durante el embarazo y se recomienda continuarlos, sobre todo considerando que el mayor riesgo de complicaciones esta asociado a una enfermedad activa. Sin embargo es importante considerar las opciones caso a caso. Las dos grandes excepciones son metotrexato y talidomida que estan completamente contraindicadas. La recomendacion mas importante es educar a toda paciente con EII en edad reproductiva, explicando que el embarazo debe llevarse a cabo cuando la enfermedad este controlada y que la probabilidad de complicaciones esta relacionada con el grado de actividad y severidad de la EII. Los medicos tratantes deben educar a las pacientes, enfatizando el seguimiento de los controles y tratamiento.
Low-lying energy levels in odd-mass Sc isotopes

Abstract The reactions 46Ti(p, α)43Sc, 48Ti(p, α)45Sc and 50Ti(p, α)47Sc were initiated in isotopically enriched and natural targets with protons of 9, 9.5 and 10 MeV from a tandem accelerator. The reaction products were analysed and detected at 45°, 60° and 125° with a magnetic spectrograph. The Q values, excitation energies and absolute cross sections were determined. The energy level spectra of 43Sc, 45Sc and 47Sc emerging from this and other recent work are used to determine the applicability of several nuclear models to these nuclei.