cssi/SciSciGPT-SciSciNet huggingface dataset:
Intake of key chronic disease-related nutrients among baby boomers.

OBJECTIVES The dietary habits of baby boomers (people born between 1946 and 1964) undoubtedly will have a substantial impact on their future health; however, dietary information regarding the intake of key chronic disease-related nutrients is lacking for this generation. The objective of this study was to compare the dietary intake of key chronic disease-related nutrients of the baby boomer generation with the previous generation of middle-aged adults. METHODS National cross-sectional study comparison analyzing data from the National Health and Nutrition Examination Survey (NHANES) including NHANES III (1988-1994) and the NHANES for 2007-2010, focused on adult respondents ages 46 to 64 years who were not institutionalized at the time of each survey. The two cohorts were compared with regard to dietary intake of key nutritional components. The main outcome measures were intake of total calories, sodium, cholesterol, fat, fruits, vegetables, vitamin C, water, and fiber. RESULTS The baby boomers' average daily intake of nutrients exceeded that of the previous generation of middle-aged adults for total calories (2118/1999), total fat (82/76 g), sodium (3513/3291 mg), and cholesterol (294/262 g; all P < 0.001). The intake of vitamin C (105/89 g), water (1208/1001 g), and vegetables (199/229 g) was less than that of the previous generation (P < 0.001), and the dietary intake of fruit and fiber was unchanged. In regression analyses, dietary changes remained significant after controlling for age, race, sex, and socioeconomic status (all P < 0.01). CONCLUSIONS The study findings document higher dietary intake of key chronic disease-related nutrients along with reduced vegetable intake among baby boomers compared with the previous generation of middle-aged adults. These findings are indicative of a diet that may contribute to increased rates of chronic disease among individuals in this age group.
Social Networking, Learning, and Civic Engagement: New Relationships between Professors and Students, Public Administrators and Citizens

Social networking is increasingly ubiquitous, and there is growing demand for professors and public administrators to use social networking to engage with students and citizens in new and more coll...
The Faith of George W. Bush: The Personal, Practical, and Political

When historians and political scientists reinterpret the religious beliefs and practices of long-dead presidents, and attempt to ascertain the impact of a president’s faith on his politics, they are often limited to a handful of original documents, and a finite amount of historical records. Often the depiction turns on interpretations of a few key facts—whether a president regularly attended church or mentioned God in his personal letters. Often historians wish for a richer source of information.
Representing Revolution in Milton and his Contemporaries: Religion, Politics, and Polemics in Radical Puritanism

Acknowledgements Note on abbreviations and citations Introduction Part I. Radical Puritanism and Polemical Responses: 1. Lilburne, Leveller polemic and the ambiguities of the Revolution 2. Gerrard Winstanley and the crisis of the Revolution 3. Ranter and Fifth Monarchist prophecies: the revolutionary visions of Abiezer Coppe and Anna Trapnel 4. The War of the Lamb: the revolutionary discourse of George Fox and early Quakerism 5. Marvell, the saints and the Protectorate Part II. Milton: Radical Puritan Politics, Polemics and Poetry: 6. Milton, Antichristian revolts and the English Revolution 7. Radical Puritan politics and Satan's revolution in Paradise Lost 8. The kingdom within: radical religion and politics in Paradise Regained 9. The saint's revenge: radical religion and politics in Samson Agonistes Afterword - two-handed engine: politics and spiritual warfare in the 1671 poems Notes Index.
ADDH And Methylphenidate Response

The dose-response, clinical effectiveness, and response prediction in 76 children with ADDH treated with methylphenidate (MPH) were evaluated by a double-blind, placebo-controlled, crossover study at the Department of Psychology, University of Hawaii, Honolulu.
Mind the Gap: A Study in Global Development Through Persistent Homology

The Gapminder project set out to use statistics to dispel simplistic notions about global development. In the same spirit, we use persistent homology, a technique from computational algebraic topology, to explore the relationship between country development and geography. For each country, four indicators, gross domestic product per capita; average life expectancy; infant mortality; and gross national income per capita, were used to quantify the development. Two analyses were performed. The first considers clusters of the countries based on these indicators, and the second uncovers cycles in the data when combined with geographic border structure. Our analysis is a multi-scale approach that reveals similarities and connections among countries at a variety of levels. We discover localized development patterns that are invisible in standard statistical methods.
HISTORICAL DEVELOPMENT OF THE FINANCIAL REPORTING MODEL FOR STATE AND LOCAL GOVERNMENTS IN THE UNITED STATES FROM LATE 1800s TO 1999

This study examines the historical development of the financial reporting model for state and local governments in the United States from the late 1800s through the issuance by the Governmental Accounting Standards Board (GASB) of Statement No. 34 in 1999. This research shows how the current governmental reporting standard evolved over time to meet diverse user needs by presenting both government-wide and fund statements, and requiring three governmental operating statements with potentially three different measurement focuses: the Statement of Activities; the Statement of Revenues, Expenditures, and Changes in Fund Balances; and the Budgetary Comparison Schedule. Overall, this historical study provides unique insights about the development of the governmental reporting model and an appreciation for the reporting requirements of GASB Statement No. 34.
Understanding Gender Differences in Rape Victim Blaming: The Power of Social Influence and Just World Beliefs:

Victims of sexual violence are frequently blamed by friends, family, or legal personnel in the aftermath of an attack, with men attributing greater blame on average than women. Victims' experiences of being blamed may generate a vicious cycle in which they are more likely to be blamed in the future. Moreover, just world beliefs (JWB) have been studied extensively as an underlying cognitive mechanism that predicts greater blame. Studies examining the influence of social support on blame have yet to examine the unique role of JWB on these attributions. The current study examined blame attribution of a fictional rape victim who received either positive, negative, or neutral support from friends and family in a sample of 383 undergraduate men and women. Individually, social support and JWB were both significant predictors of blame, and women were more influenced by social support than men; specifically, gender was a more salient predictor of blame toward the positively supported victim, suggesting that positive support received by friends and family may evoke a domino effect of support from other women. Conditional effects revealed that JWB were most influential on blame when responding to the positively supported victim. Implications and suggestions for future research are discussed.
Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We explored if cortical neurons detected by NeuN decreased with increasing TDP-43 inclusion pathology in the postmortem brains of 63 patients with sporadic and familial FTLD-TDP. Semi-automated quantitative algorithms to quantify histology in tissue sections stained with antibodies specific for pathological or phosphorylated TDP-43 (pTDP-43) and NeuN were developed and validated in affected (cerebral cortex) and minimally affected (cerebellar cortex) brain regions of FTLD-TDP cases. Immunohistochemistry (IHC) for NeuN and other neuronal markers found numerous neurons lacking reactivity, suggesting NeuN may reflect neuron health rather than neuron loss in FTLD. We found three patterns of NeuN and pTDP-43 reactivity in our sample of cortical tissue representing three intracortical region-specific stages of FTLD-TDP progression: Group 1 showed low levels of pathological pTDP-43 and high levels NeuN, while Group 2 showed increased levels of pTDP-43, and Group 3 tissues were characterized by reduced staining for both pTDP-43 and NeuN. Comparison of non-C9orf72/GRN FTLD-TDP with cases linked to both GRN mutations and C9orf72 expansions showed a significantly increased frequency of Group 3 histopathology in the latter cases, suggesting more advanced cortical disease. Hence, we propose that IHC profiles of pTDP-43 and NeuN reflect the burden of pTDP-43 and its deleterious effects on neuron health.
“To Life”: Biblical Narratives, Positive Psychology, and Suicide-Prevention

Some 16 suicides and self-mutilations can be found in the 26 surviving tragedies of Sophocles and Euripides. In contrast, only 6 suicides can be found in the Hebrew Scriptures, and 1 suicide in the Christian New Testament. In addition, the Hebrew Scriptures present a number of suicide-prevention narratives largely absent in Greek legends underlying much of mental health. In other words, the Hebrew Scriptures seem to provide a psychological stopper for people in despair which seems unavailable to figures in the writings of the great Greek tragedians. This chapter examines evidence regarding seven risk factors for suicide: (1) feeling isolated and ignored; (2) feeling one’s life is without meaning; (3) feeling exiled from one’s home or homeland (feeling as a refugee or an outcast); (4) feeling unable to be oneself with others; (5) being raised in a foster home and later feeling alone in one’s life mission; (6) feeling abandoned by one’s child leaving the family nest and building his/her own life; and (7) feeling doomed by a dysfunctional (even incestuous) family of origin. We contrast biblical and Greek narratives regarding each of these factors, respectively: (1) Elijah against Ajax, (2) Job against Zeno, (3) David against Coriolanus, (4) Jonah against Narcissus, (5) Moses against Oedipus, (6) Rebecca against Phaedra, and finally, (7) Ruth against Antigone. All these contrasts should demonstrate to psychotherapists, counsellors, and clergy alike as to how Greek narratives lead to self-destructive behaviours while biblical narratives provide a hopeful positive psychology, and a safe way out of these dilemmas. It is high time to develop a Biblical Psychology.
From .com to com.cn: A case study of website internationalization

MediaCentral.com had a success story in solving lots of unique issues in the process of internationalizing a website. Although their investments were huge in the beginning of the process, it paid off as the China site became one of the most popular e-commerce website in China. This chapter discusses some key things for setting up Media-Central.com in China. It includes: conducting significant market research and user experience research is before the efforts of launching an international site to understand the market and analyze the potential return on investment, involving people who are very familiar with the culture and the language of the target market, designing a site for audiences in a different culture always involves much more effort than straight translation, content and presentation needs to be adjusted according to contexts and local perceptions, and many user preferences and conventions should be taken into consideration in the design.
Physical Therapy, Physical Modalities, and Exercise Regimens in the Management of Osteoporosis

Abstract Osteoporosis was first recognized as a systemic disease in 1990 when a consensus development conference defined osteoporosis as “a systemic skeletal disease” that leads to an increased “susceptibility to fracture”. In other words, osteoporosis is the disease; fracture is the sequelae. Since then, we have made major advances in understanding the epidemiology of this common and chronic disease, elucidating its pathophysiology, identifying its significant effect on cost, morbidity, and mortality of the consequent fractures. In addition, a number of pharmacologic agents have been developed that have been proven effective in preventing the disease and its sequelae (i.e., fracture). As with any chronic systemic disease, however, management of the patient requires more than pharmaceuticals. Appropriate treatment requires a comprehensive management program that includes both fracture prevention and management of symptoms such as pain, decreased mobility, decreased function, social isolation, and depression. This requires a multidisciplinary approach involving many health professionals including physical therapists.
Impact of Cache Voltage Scaling on Energy-Time Pareto Frontier in Multicore Systems

Abstract High performance computing centers need to keep up with the growing workload of varying computational characteristics. Due to their high computation rates, these computing systems consume vast amounts of energy with increasing electricity costs. As an approach to balancing computation demand with energy consumption, state-of-the-art dynamic voltage and frequency scaling (DVFS) methodologies are used for improving the energy efficiency of computing systems. However, these studies often do not explore the extent to which their solutions are close to theoretically optimal limits. This work formulates optimal boundaries for energy-time performance with a Linear Programming (LP) approach. The formulation utilizes per-core energy consumptions and execution times obtained during the profiling phase to optimize the voltage and frequency (V/F) level assignments at runtime. For each of the four benchmarks considered in this work, the optimized V/F assignments are used to bound Pareto frontiers, which trade off energy consumption and execution time. In particular, this work studies the impact of scaling the voltage and frequency of the cache subsystem in a multicore system on establishing the energy-time Pareto frontier. An unexpected result of our study is that when the frequencies of caches are not scaled with that of the cores (i.e., fixed at 2.0 GHz), the proposed LP-based technique improves the overall Energy-Delay-Product (EDP) as much as 35% compared to the traditional no-DVFS Pareto frontier. Furthermore, this work compares the performance of three heuristic-based energy-efficient DVFS algorithms to demonstrate the differences between heuristics performances and the LP-based optimal Pareto frontier.
Fourier-Domain Shift Matching: A Robust Time-of-Flight Approach for Shear Wave Speed Estimation

Our primary objective of this work was to design and test a new time-of-flight (TOF) method that allows measurements of shear wave speed (SWS) following impulsive excitation in soft tissues. Particularly, under the assumption of the local plane shear wave, this work named the Fourier-domain shift matching (FDSM) method, estimates SWS by aligning a series of shear waveforms either temporally or spatially using a solution space deduced by characteristic curves of the well-known 1-D wave equation. The proposed SWS estimation method was tested using computer-simulated data, and tissue-mimicking phantom and ex vivo tissue experiments. Its performance was then compared with three other known TOF methods: lateral time-to-peak (TTP) method with robust random sampling consensus (RANSAC) fitting method, Radon sum transformation method, and a modified cross correlation method. Hereafter, these three TOF methods are referred to as the TTP-RANSAC, Radon sum, and X-corr methods, respectively. In addition to an adapted form of the 2-D Fourier transform (2-D FT)-based method in which the (group) SWS was approximated by averaging phase SWS values was considered for comparison. Based on data evaluated, we found that the overall performance of the above-mentioned temporal implementation of the proposed FDSM method was most similar to the established Radon sum method (correlation = 0.99, scale factor = 1.03, and mean difference = 0.07 m/s), and the 2-D FT (correlation = 0.98, scale factor = 1.00, and mean difference = 0.10 m/s) at high signal quality. However, results obtained from the 2-D FT method diverged (correlation = 0.201) from these of the proposed temporal implementation in the presence of diminished signal quality, whereas the agreement between the Radon sum approach and the proposed temporal implementation largely remained the same (correlation = 0.98).
Kaposi sarcoma incidence in females is nearly four-fold higher in the Lower Rio Grande Valley compared to the Texas average

Abstract The Lower Rio Grande Valley (LRGV) is located on U.S.-Mexican border with a population that is 90% Hispanic [1] . Comprised of Hidalgo, Cameron, Starr and Willacy counties, this region has the highest poverty rate and one of the highest incidences of Type 2 diabetes in the United States [2] , [3] , [4] . Previous studies demonstrated a high prevalence of Human Herpes Virus 8 (HHV8) in the LRGV [5] , [6] , [7] . HHV8 infection has been causally linked to Kaposi Sarcoma (KS) [8] . Here, we retrospectively examine the incidence of KS in the LRGV in a set of HIV-negative Hispanic patients. Strikingly, the incidence of KS was higher in LRGV women compared to the Texas state average (nearly four-fold higher in McAllen-Edinburg-Pharr Metro Statistical Area). This unique profile aligns with the increased HHV8 prevalence in the LRGV, suggesting that HHV8 contributes to a high incidence of HIV-negative KS on the U.S.–Mexican border in Texas.
Sensor Conditioning Circuits

Analog sensors produces a variation in an electrical property to show a change in the environment. The analog variation in electrical property needs a conditioning circuit to indicate the change before conversion into digital signal. The electrical properties most commonly detected by analog sensors are voltage, current, capacitance, resistance, and charge. Real-time capacitive and resistive sensors are used in a wide range of physical measurement systems. Detection of a small capacitance or resistance change is widely demanded in industrial process control systems and medical instrumentations [2].
Spacesuits: development and design for thermal comfort

Abstract: The history is described of the development of protective spacesuits through parallel efforts of the USA and USSR/Russia space programs. The application of physiological design principles to develop a shortened more energy-efficient liquid cooling/warming garment component of the spacesuit, finger calorimeter, and improved space glove is presented. The factors that must be taken into account to maintain thermal control in the design of protective spacesuits for exploration missions to Mars and other planets are examined, including differing metabolic expenditure rates as planetary explorers alternate between periods of high activity and rest. Methods of improving the cooling/warming garment are considered as part of this development process.
Use of Fine-scale Geospatial Units and Population Data to Evaluate Access to Emergency Care.

Author(s): Joyce, Katherine M.; Burke, Ryan C.; Veldman, Thomas J.; Beeson, Michelle M.; Simon, Erin L | Abstract: Introduction: Time to facility is a crucial element in emergency medicine (EM). Fine-scale geospatial units such as census block groups (CBG) and publicly available population datasets offer a low-cost and accurate approach to modeling geographic access to and utilization of emergency departments (ED). These methods are relevant to the emergency physician in evaluating patient utilization patterns, emergency medical services protocols, and opportunities for improved patient outcomes and cost utilization. We describe the practical application of geographic information system (GIS) and fine-scale analysis for EM using Ohio ED access as a case study.Methods: Ohio ED locations (n=198), CBGs (n=9,238) and 2015 United States Census five-year American Community Survey (ACS) socioeconomic data were collected July—August 2016. We estimated drive time and distance between population-weighted CBGs and nearest ED using ArcGIS and 2010 CBG shapefiles. We examined drive times vs. ACS characteristics using multinomial regression and mapping.Results: We categorized CBGs by centroid-ED travel time in minutes: l10 (73.4%; n=6,774), 10-30 (25.1%; n=2,315), and g30 (1.5%; n=141). CBGs with increased median age, Hispanic and non-Hispanic Black population, and college graduation rates had significantly decreased travel time. CBGs with increased low-income populations (adjusted odds ratio [AOR] [1.03], 95% confidence interval [CI] [1.01-1.04]) and vacant housing (AOR [1.06], 95% CI [1.05-1.08]) had increased odds of g30 minute travel time.Conclusion: Use of fine-scale geographic analysis and population data can be used to evaluate geographic accessibility and utilization of EDs. Methods described offer guidance to approaching questions of geographic accessibility and have numerous ED and pre-hospital applications.
Reveal the fast and charge-insensitive lattice diffusion of silver in cubic silicon carbide via first-principles calculations

Abstract The lattice diffusion of silver with various charge states in cubic silicon carbide has been investigated by means of high-fidelity spin-polarized density functional theory calculations. The migration energy barrier of the Ag interstitial diffusion is 1.09 eV and 1.11 eV for neutral and q = + 1 e charge state, respectively, close to the activation energy of Ag diffusion measured in the German HTR fuel program. A general trend is that the migration energy barrier reduces with respect to the increase of charge on Ag, which is much less than the increment in the oxidation energy, suggesting that the lattice diffusion of silver prefers constant neutral state without redox in transition state. Our results indicate a scenario that once Ag is deposited to interstitials via the kickout mechanism, it will highly likely perform lattice diffusion across the SiC layer leading to fast release of Ag in Tristructural-Isotropic fuel induced by irradiation.
Select Papers from the XIXth Biennial Interdisciplinary Conference on Netherlandic Studies

The following articles were originally presented at the 19th biennial Interdisciplinary Conference on Netherlandic Studies. Held in Bloomington at Indiana University in June 2018, the conference wa...
Editor's Choice: Dual-process model of older adults' sedentary behavior: an ecological momentary assessment study.

Objective: A 10-day ecological momentary assessment (EMA) study was conducted to test a dual-process model of older adults’ sedentary behavior.Design: Older adults (n = 104, 60–98 years) answered 6...
Left Ventricular Assist Devices 101: Shared Care for General Cardiologists and Primary Care

Ambulatory patients with a left ventricular assist device (LVAD) are increasing in number, and so is their life expectancy. Thus, there is an increasing need for care of these patients by non-LVAD specialists, such as providers in the emergency department, urgent care centers, community-based hospitals, outpatient clinics, etc. Non-LVAD specialists will increasingly come across LVAD patients and should be equipped with the knowledge and skills to provide initial assessment and management for these complex patients. These encounters may be for LVAD-related or unrelated issues. However, there are limited data and guidelines to assist non-LVAD specialists in caring for these complex patients. The aim of our review, targeting primary care providers (both inpatient and outpatient), general cardiologists, and other providers is to describe the current status of durable LVAD therapy in adults, patient selection, management strategies, complications and to summarize current outcome data.
A National Survey of Teaching and Learning Research Methods: Important Concepts and Faculty and Student Perspectives:

In this study, we assessed instructor and student attitudes and knowledge toward research methods (RM). Instructors (N = 62) answered questions about course format, topic importance, and resources....
Sublattice melting in binary superionic colloidal crystals

In superionic compounds one component premelts, providing high ionic conductivity to solid-state electrolytes. Here we find sublattice melting in colloidal crystals of oppositely charged particles that are highly asymmetric in size and charge in salt solutions. The small particles in ionic compounds melt when the temperature increases, forming a superionic phase. These delocalized small particles in a crystal of large oppositely charged particles, in contrast to superionic phases in atomic systems, form crystals with nonelectroneutral stoichiometric ratios. This generates structures with multiple domains of ionic crystals in percolated superionic phases with adjustable stoichiometries.
GLIDE: combining local methods and diffusion state embeddings to predict missing interactions in biological networks.

Motivation One of the core problems in the analysis of biological networks is the link prediction problem. In particular, existing interactions networks are noisy and incomplete snapshots of the true network, with many true links missing because those interactions have not yet been experimentally observed. Methods to predict missing links have been more extensively studied for social than for biological networks; it was recently argued that there is some special structure in protein-protein interaction (PPI) network data that might mean that alternate methods may outperform the best methods for social networks. Based on a generalization of the diffusion state distance, we design a new embedding-based link prediction method called global and local integrated diffusion embedding (GLIDE). GLIDE is designed to effectively capture global network structure, combined with alternative network type-specific customized measures that capture local network structure. We test GLIDE on a collection of three recently curated human biological networks derived from the 2016 DREAM disease module identification challenge as well as a classical version of the yeast PPI network in rigorous cross validation experiments. Results We indeed find that different local network structure is dominant in different types of biological networks. We find that the simple local network measures are dominant in the highly connected network core between hub genes, but that GLIDE's global embedding measure adds value in the rest of the network. For example, we make GLIDE-based link predictions from genes known to be involved in Crohn's disease, to genes that are not known to have an association, and make some new predictions, finding support in other network data and the literature. Availability and implementation GLIDE can be downloaded at https://bitbucket.org/kap_devkota/glide. Supplementary information Supplementary data are available at Bioinformatics online.
Towards a high-accuracy kinetic database informed by theoretical and experimental data: CH3 + HO2 as a case study

Abstract The reliability of predictive simulations for advanced combustion engines depends on the availability of accurate data and models for thermochemistry, chemical kinetics, and transport. In that regard, accurate data are critically important for both their direct use in predictive simulations and for benchmarking improved theoretical methodologies that can similarly produce accurate data for predictive simulations. The use of informatics-based strategies for the determination of accurate thermochemical data with well-defined uncertainties, e.g. the Active Thermochemical Tables (ATcT), has revolutionized the field of thermochemistry–providing thermochemical data of unprecedented accuracy for predictive combustion simulations and has served as a key enabler of ab initio electronic structure methodologies of equally impressive accuracy. Clearly, pursuit of informatics-based analogs in chemical kinetics would be similarly worthwhile. Here, we present results and analyses for the kinetics of CH3 + HO2 reactions that demonstrate some key elements of any approach to developing analogs for kinetics, including: the importance of raw data for quantifying the information content of experimental data, the utility of theoretical kinetics calculations for constraining experimental interpretations and providing an independent data source, and the subtleties of target data selection for avoiding unphysical parameter adjustments to match data affected by structural uncertainties. Notably, we find the optimization performed here using the MultiScale Informatics (MSI) approach applied to carefully selected (mostly raw) experimental data yields an opposite temperature dependence for the channel-specific CH3 + HO2 rate constants as compared to a previous rate-parameter optimization. While both optimization studies use the same theoretical calculations to constrain model parameters, only the present optimization, which incorporates theory directly into the model structure, yields results that are consistent with theoretical calculations.
Naturalness, Personality, and Mindfulness Predict EcoWellness: Implications for Counseling Practice

This study explored the role of individual differences in relation to overall EcoWellness (Reese and Myers in Journal of Counseling & Development, 90, 400-406, 2012) in a sample of online participants situated in the United States. Data were collected through self-report measures of mindfulness, personality traits, EcoWellness, and perceived naturalness of environmental settings. Aspects of mindfulness, greater perceived naturalness, extraversion, agreeableness, and openness predicted overall EcoWellness. Thus, individuals who scored higher on these traits were more likely to be regarded as EcoWell. These findings give insight to who might benefit from counseling interventions targeting EcoWellness and help to further build a conceptual understanding of the concept of EcoWellness in the international counseling literature.
Single-Shot Ptychographic Imaging of Femtosecond Laser Induced Plasma Dynamics

We present, to our knowledge, the first Single-Shot Ptychographic imaging of a continuously dynamic object. We also present the first ptychographic imaging of a plasma induced event created from a femtosecond laser breakdown in air.
Family cohesion and the relations among peer victimization and depression: A random intercepts cross-lagged model

The relation between peer victimization and depressive symptoms is complex, requiring the use of methodologically rigorous designs to examine these relations and potential mediating factors. The current study used a random intercepts cross-lagged panel model (RI-CLPM) to investigate both between-person and within-person associations in peer victimization, depressive symptoms, and family cohesion across five waves in a sample of adolescents (N = 801, ages 13-15 years at recruitment) in the Northeast. We also investigated the moderating effects of sex and victimization status (i.e., bullying victimization vs. peer victimization). Overall, findings revealed a reciprocal relation between peer victimization and depressive symptoms for females, but no relation for males. A reciprocal relation between peer victimization and family cohesion was found for males. No significant differences were found by victimization status. Future research on peer victimization and associated outcomes and the role of family should account for both between-person and within-person variance.
Impact of Multiplicity Fluctuations on Entropy Scaling Across System Size

The initial state is one of the greatest uncertainties in heavy-ion collisions. A model-agnostic approach is taken in the phenomenological Trento framework which constrains parameters using Bayesian analysis. However, the color-glass condensate (CGC) effective theory predicts initial energy densities that lie outside the recent Bayesian analyses due, in part, to the assumption in Trento of event-by-event multiplicity fluctuations following a $\Gamma$ distribution. We compare the Trento-preferred $\sqrt{T_{A}T_{B}}$ scaling to CGC-like $T_{A}T_{B}$ scaling coupled with log-normal fluctuations in $AuAu$ and $dAu$ collisions and find there is a significant impact on the multiplicity distributions and on the eccentricities, which may affect the extraction of viscosity in small systems.
Perceptions of Sound Quality and Enjoyment After Cochlear Implantation.

ObjectivesTo characterize the quality and enjoyment of sound by cochlear implant (CI) recipients and identify predictors of these outcomes after cochlear implantation.Study DesignCross-sectional st...
Therapeutic vaccination strategies against EBOV by rVSV-EBOV-GP: the role of innate immunity

Zaire Ebola virus (EBOV) is a member of the Filoviridae family. Infection with EBOV causes Ebola virus disease (EVD) characterized by excessive inflammation, lymphocyte death, coagulopathy, and multi-organ failure. In 2019, the FDA-approved the first anti-EBOV vaccine, rVSV-EBOV-GP (Ervebo® by Merck). This live-recombinant vaccine confers both prophylactic and therapeutic protection to nonhuman primates and humans. While mechanisms conferring prophylactic protection are well-investigated, those underlying protection conferred shortly before and after exposure to EBOV remain poorly understood. In this review, we review data from in vitro and in vivo studies analyzing early immune responses to rVSV-EBOV-GP and discuss the role of innate immune activation in therapeutic protection.
Scheduling Wind-Optimal Central East Pacific Flights

This study addresses one of the issues being raised as a Concept of Operation (CONOPS) is being developed for the Next Generation Air Transportation System (NextGen), systems to maximize the use of the oceanic domain airspace through new ways of enhancing situational awareness by pilots and new routes that take advantage of wind conditions. Some of these efforts are creating concern about the significant number of new four-dimensional (4-D) crossing points under user-generated routing. These could significantly increase air traffic controllers’ workloads. In this study, new single and multi-objective binary integer programming models that are derivatives of a model originally developed to solve a deterministic traffic flow management problem are proposed. They minimize the total scheduling delay and the weighted sum of the scheduling delay and the number of residual trajectory merge points that are allowed. The study also leverages an innovative technique for transforming a flight scheduling problem into a job scheduling problem. After routing all flights in the Central East Pacific (CEP) on wind-optimal routes and strategically scheduling the flights to reduce the number of trajectory merge points, the delays are calculated. A multi-objective binary integer program is developed to allow trade-offs between the number of trajectory merge points and delays. A trade-off frontier was calculated for a 24-hour scheduling problem. Future trade-offs can be calculated based on what is tolerable in the CEP to implement strategic scheduling.
Graph analytics techniques

There are many ways to analyze a graph. There are graph-wide metrics to quantify attributes of a graph such as diameter and density. You can compare your instance graph with a comparable regular, small-world, or random graph. The shape and size of a graph may tell you some interesting things about that graph. Fine-grained characteristics that are also useful consider connectivity of nodes in the graph, characteristics of paths, and the presence and size of clusters within the graph. This chapter provides a conceptual overview of analytics that fall into those three categories. It describes several node-based metrics such as degree and betweenness centrality, which can be used to learn more about a given node or about the distribution of degrees of connectivity within a graph. Path metrics can be used to calculate the shortest path between nodes, the average path length, or to look for special kinds of paths such as cycles in directed graphs. Clusters are groupings of nodes that have a special relationship to one another as compared to the graph as a whole, revealed by the relatively interconnectedness of nodes that fall within the cluster as compared to those which do not.
Novel Acoustic Techniques for Assessing Fish Schooling in the Context of an Operational Ocean Observatory

Abstract : Fish aggregation is important in terms of biology, fisheries, and measurement, quantitative analyses of gregarious movement behaviors remain relatively rare (Turchin 1989). Fish aggregation has most often been studied in easily accessed fish or fish easily maintained in the laboratory such as minnows and dace (see a review in Pitcher and Parrish 1993). Measurements of fish aggregations are often difficult, particularly in pelagic environments. Our goal is to develop new acoustic techniques that have the potential to serve as measurement tools to quantify this ubiquitous and important behavior.
Estimation of grid-induced errors in computational fluid dynamics solutions using a discrete error transport equation

Computational fluid dynamics (CFD) has become a widely used tool in research and engineering for the study of a wide variety of problems. However, confidence in CFD solutions is still dependent on comparisons with experimental data. In order for CFD to become a trusted resource, a quantitative measure of error must be provided for each generated solution. Although there are several sources of error, the effects of the resolution and quality of the computational grid are difficult to predict a priori. This grid-induced error is most often attenuated by performing a grid refinement study or using solution adaptive grid refinement. While these methods are effective, they can also be computationally expensive and even impractical for large, complex problems. This work presents a method for estimating the grid-induced error in CFD solutions of the Navier-Stokes and Euler equations using a single grid and solution or a series of increasingly finer grids and solutions. The method is based on the discrete error transport equation (DETE), which is derived directly from the discretized PDE and provides a value of the error at every cell in the computational grid. The DETE is developed for two-dimensional, laminar Navier-Stokes and Euler equations within a generalized unstructured finite volume scheme, such that an extension to three dimensions and turbulent flow would follow the same approach. The usefulness of the DETE depends on the accuracy with which the source term, the gridinduced residual, can be modeled. Three different models for the grid-induced residual were developed: the AME model, the PDE model, and the extrapolation model. The AME model consists of the leading terms of the remainder of a simplified modified equation. The PDE model creates a polynomial fit of the CFD solution and then uses the original PDE in differential form to calculate the residual. Both the AME and PDE are used with a single grid and solution. The extrapolation model uses a fine grid solution to calculate the grid-induced residual on the coarse grid and then extrapolates that residual back to the fine grid. The DETE and residual models were then evaluated for four flow problems: (1) steady flow past a circular cylinder; (2) steady, transonic flow past an airfoil; (3) unsteady flow of an isentropic vortex; (4) unsteady flow past a circular cylinder with vortex shedding. Results demonstrate the fidelity of the DETE with each residual model as well as usefulness of the DETE as a tool for predicting the grid-induced error in CFD solutions.
Economic Regulation of Intrastate Air Carriers in California

statutory provisions relating to Public Utilities Commission jurisdiction. Because of unique geographic and economic factors, commercial intrastate air travel has developed faster and with greater economic significance in California than in any other state. Attendant legal questions have arisen out of the uncertainty regarding the extent of exclusive federal control as well as from the application to those activities which are not subject to exclusive federal jurisdiction of certain state constitutional provisions, adopted while the airplane was still a combination box-kite and windmill not imagined as a means of mass transportation. Future developments in California may well lead the way towards settling the problems of federal, state and local regulation of air travel throughout the nation. The unlimited potential of air travel and its rapid development in recent years shows the need for resolution of the jurisdictional issues created by present laws and decisions, and for the development of a far-sighted and sympathetic governmental attitude to realize this potential. A comparable opportunity to further the development of intrastate and local-service air transportation may never again arise if the present solution of these problems is not forthright and effective. Congress and the states have not yet produced a sound regulatory pattern. Air carriers, serving many masters, face a nearly impenetrable mass of confusion, duplication and uncertainty in economic regulation. This complexity of regulation has an important adverse affect on the development of an air transportation system which will serve national, sectional and local needs adequately. This fact requires the resolution of existing jurisdictional conflicts and the establishment of a flexible regulatory framework aimed at maximum social utilization of the inherent advantages of the airplane. The framework should be tight enough to protect the public interest in safety, service and competition, and loose enough to permit the still unrealized potential of air transportation to develop as rapidly as eco-
Abstract 1785: Ubiquitin specific protease 3 is a regulator of histone ubiquitination required for maintenance of genomic stability.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC The ubiquitination of histones is crucial for the maintenance of genomic stability. Little is understood about the deubiquitinating enzymes that catalyze the removal of ubiquitin from histones in response to UV damage. In this study, we identify the ubiquitin-specific protease 3 (USP3) as a deubiquitinating enzyme which catalyzes the cleavage of ubiquitin from γH2AX and uH2A in response to UV damage. Using GFP-tagged USP3 we demonstrate that USP3 is a nuclear protein. To determine the function of USP3 in chromatin regulation we ectopically expressed USP3 in Hela cells and analyzed the ubiquitination status of histones. Our analysis demonstrated that the overexpression of the wild type USP3 (USP3wt), but not the catalytically inactive mutant (USP3C1685) resulted in a decrease in the ubiquitination of γH2AX and uH2A. This result was further supported by the functional ablation of USP3 by RNAi. The efficient reduction of the USP3 protein was accompanied by a significant increase in the levels of uH2A and the ubiquitination of γH2AX. In addition, we were also able to demonstrate that the depletion of USP3 increases the persistence of uH2A and Fk2 foci formation in response to UV damage. Together, our results implicate that USP3 is involved in the removal of ubiquitin marks from chromatin-bound proteins as a means to attenuate the damage signal. Thus, in the presence of UV damage, the functional ablation of USP3 may lead to a delay in cell cycle progression and the activation of checkpoint signals, which in turn could induce genotoxic stress. This work was supported by the PHS grant ES2388, ES12991 and CA93413. Citation Format: Nidhi Sharma, Qianzheng Zhu, Qi-En Wang, Altaf A. Wani. Ubiquitin specific protease 3 is a regulator of histone ubiquitination required for maintenance of genomic stability. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1785. doi:10.1158/1538-7445.AM2013-1785
Herbs and atherosclerosis

It is now widely accepted that atherosclerosis is a complex multicellular process involving oxidation of cholesterol and the intracellular accumulation of oxidized cholesterol. This accumulation causes a cascade of inflammatory processes, resulting in an unstable atherosclerotic plaque that ultimately bursts, causing myocardial infarction. Botanical dietary supplements (herbs) can ameliorate this process and prevent cardiovascular disease at many steps in the process. Many herbs have antioxidant activity and can reduce low-density lipoprotein oxidation. Some phytosterols found in botanicals can inhibit cholesterol absorption. After a brief review of herbs being promoted for achieving and maintaining healthy cholesterol levels, the evidence and future prospects for Chinese red yeast rice, the main component of dietary supplements with HMG-CoA reductase inhibiting activity, are discussed in detail. Initial phase II clinical trials are highly encouraging. This herb is likely to be able to directly impact the process of atherosclerosis, but large-scale clinical trials are needed to assess the public health potential of this herbal supplement.
Fourier transform spectrometry of rare earth elements for the lighting industry

Branching fractions for neutral holmium have been measured with FT spectrometry. Hyperfine structure patterns have been analyzed using a modified Xgremlin program.
Immigration and freedom of movement

In this paper I focus on one very influential argument for open borders, the freedom of movement argument, which says that if we value freedom of movement we must demand open borders. I begin the paper the paper by discussing Joseph Carens’ well known version of the argument. I then consider, and reject, David Miller’s response to that argument. Finally, I develop my own reply to Carens. Both Carens and Miller, I argue, are mistaken about the proper grounds for freedom of movement. Once we see this, it is clear how we can value freedom of movement without being committed to open borders. Keywords: political theory; philosophy; ethics (Published: 1 March 2013) Citation: Ethics & Global Politics, Vol. 6 , No. 1, 2013, pp. 25-37. http://dx.doi.org/10.3402/egp.v6i1.18188