cssi/SciSciGPT-SciSciNet huggingface dataset:
Microgravimetric preparation and characterisation of catalyst candidates for fuel cell electrodes

Abstract In the search for noble-metal-free cathode materials resistant to acid electrolytes and capable of catalysing the conversion of oxygen, thermogravimetric methods have been used to determine the conditions of preparation, to analyse the chemical properties, and to characterise the pore structure of the potential catalysts. The paper comprises results of investigations on inorganic compounds, such as ammonium tungstates, chromates, vanadates, molybdate and permanganate, and on organic polymers, such as polyamide nitriles, other CN polymers and polyacenoquinone pyrolysates.
Reversible and irreversible sources of radiation entropy

We discuss two practical issues concerning the relationship between the entropies of the atmosphere and of the radiation field. The first is whether the radiative flux of entropy can be determined from a satellite with sufficient accuracy for climate studies. We conclude that an accuracy much better than 1% is required, but that this can be achieved in the thermal spectrum with spectrometers having spectral resolutions ∼ 1 cm−1; it is also possible that the required accuracy can be achieved with a non-spectral approach. The second is whether the rate of change of the atmospheric entropy inventory can be inferred from the outgoing radiative-entropy flux. We conclude that, for clear skies in the thermal region of the spectrum, the two are directly proportional, and that the atmospheric term can be inferred with useful accuracy from an empirical relation.
LM flight simulation in the space environment

Mission simulation testing in thermal vacuum environment for Apollo Lunar Module, noting conformal skin heaters
Effects of Solar Radiation on Dissolved Organic Matter Cycling in a Subtropical Seagrass Meadow

The influence of sunlight on bacterioplankton production was investigated over a 12-month period in Laguna Madre, a shallow, subtropical, seagrass-dominated lagoon in south Texas. Two types of experiments were conducted every 6 to 8 weeks from June 1996 through June 1997 to assess the effect of photochemical transformations of dissolved organic matter (DOM) on bacterial production and the net effect of sunlight exposure on bacterioplankton and phytoplankton production in surface waters. Photobleaching of DOM was observed; however, estimates of the photomineralization of DOM in May and July were very low and indicated that this process could represent at most 3% of water column respiration. Photochemical transformations of DOM did not have any significant effect on bacterioplankton activity. However, bacterial production measured during exposure of water samples to natural sunlight in the summer months, with and without ultraviolet light, was enhanced relative to dark controls. Phytoplankton release of bioavailable substrates appeared to be responsible for light-mediated increases in bacterioplankton production. Bacterio- and phytoplankton were not photoinhibited by exposure to ultraviolet radiation in surface waters. Overall, we observed no indication of photoinhibition of microbial processes in Laguna Madre, and photochemical transformations appeared to play a minor role in the cycling of DOM. The low photoreactivity of DOM in combination with its relatively high bioreactivity appeared responsible for the minor role of photochemical transformations in the cycling of DOM in Laguna Madre.
Differences in survival among germfree mice following transfer to a conventional colony.

SummarySex and strain differences in survival were studied in 7-9 month old germfree mice following transfer to a conventional colony. One outbred and three inbred strains were observed. All outbred CD-1 mice survived transfer and in 4 months increased their weight by 50%. The majority of inbred mice survived 7 months after transfer. Sex differences in survival were evident throughout the experimental period and were most marked 7 months after transfer. An unexpected new finding was the viability of the male sex in germfree mice after transfer. Possible explanations are considered.
Transmitted minority drug-resistant HIV variants: a new epidemic?

Despite high rates of viral turnover and viral evolution, HIV has proven to be surprisingly easy to suppress with combination antiretroviral therapy (ART) in the regions of the world where such treatment is available. Recent reports indicate that the vast majority of patients initiating ART should be able to achieve durable if not indefinite viral suppression [1]. Given that there are now over 20 antiretroviral drugs from six unique classes, even if one regimen fails, others are often readily available. The emerging consensus among clinicians and clinical investigators is that fewer and fewer patients will generate highly resistant HIV during the course of their treatment.
Terracing in HgCdTe LPE films grown from Te solution

Abstract Terracing in HgCdTe films grown by LPE from Te solution is influenced by many factors. These include melt-back of the substrate, substrate holder design, rotation rate of the substrate, thermal gradients, and growth rates. Many of the variables which influence terracing are interdependent and can be related to their effects on the supersaturation. Variables which tend to level the solute and/or thermal fields would tend to reduce terracing.
Toward better terminology of behavioral symptoms of dementia.

Introduction of the Minimum Data Set (MDS) 3.0 provides anopportunity to achieve some uniformity in terminology used forbehavioral problems occurring during provision of care to theperson with dementia who does not cooperate with the caregiver.In the MDS 2.0, this problem was called “resists care” but this termwas sometimes considered as blaming the resident and invitingefforts toovercome the resistance by force. MDS 3.0 uses “rejectionof care” instead of “resists care” and speciﬁes that this is a problemonly if the resident rejects care that is “necessary to achieve theresident’s goals for health and well being.”Ishiietal
Decision responsibility, task responsibility, identifiability, and social loafing

Abstract Two laboratory experiments were conducted. Results of the first experiment revealed that identifiability had no impact on the degree of cognitive loafing when group members were asked to make a decision. Identifiability did have an impact when group members were asked to express an opinion. The second experiment replicated findings of the first experiment and, in addition, indicated that unidentifiable individuals with sole task responsibility loafed more than unidentifiable individuals who shared task responsibility. Cognitive effort was measured through recall of stimulus material.
Cotton response to zinc fertilizer

Abstract The purpose of this investigation was to evaluate cotton (Gossypium hirsutum L.) response to zinc (Zn) fertilization in terms of plant growth and development and yield components. Therefore, the effects of Zn fertilizer (ZnSO4) on cotton plants were investigated in both field experiments and pot trials. Application of zinc sulfate promoted nutrient (N, P, and K) uptake, utilization, and metabolism, slightly increased root and shoot growth, bloom, dry matter production, and improved cotton quality.
Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes

To further our studies on collagen gene expression, we have evaluated the molecular basis for the finding that steroids decrease collagen synthesis in cultured hepatocytes. We studied the effects of dexamethasone on primary cultures of adult rat hepatocytes grown on tissue culture plastic in either serum-supplemented medium or a serum-free hormonally defined medium. Cells were plated and allowed to attach for 24 hr in a mixture of serum-supplemented medium + hormonally defined medium. Cultures were then fed every 24 hr for 4 days under 1 of 4 conditions: serum-supplemented medium, serum-supplemented medium + dexamethasone, hormonally defined medium or hormonally defined medium + dexamethasone. On the fifth day, RNA was extracted. Dexamethasone did not affect the amount of RNA isolated; nor did it influence the quantitative translation of the mRNA in the rabbit reticulocyte lysate mRNA-dependent system. Employing hybridization analysis, dexamethasone resulted in increased albumin mRNA content in hepatocytes grown in serum-supplemented medium but had no affect on hormonally defined medium, and decreased type I in collagen mRNA content in cells grown in either serum-supplemented medium or hormonally defined medium. In cells cultured in hormonally defined medium, the β-actin and procollagen mRNA levels were lower than those in serum-supplemented medium, but albumin mRNA levels were higher, and in fact equivalent to those in vivo. β-Actin mRNA levels were not affected by dexamethasone in either serum-supplemented medium or hormonally defined medium. These results suggest that hormonally defined medium improves the expression of tissue-specific functions in hepatocytes, and dexamethasone reduces Type I collagen mRNA content in hepatocytes as well as mesenchymal cells. It is presently not clear whether the changes in albumin and collagen steady state mRNA levels are due to transcriptional and/or post-transcriptional controls.
Mathematical analysis of emergency ambulance location

Abstract Proper ambulance location is crucial in saving lives and reducing injury. To determine efficient and effective locations, it is necessary to evaluate both the spatial and temporal distributions of demand. Because of the complex nature of the ambulance response and transport activities, the problem is subdivided into a facility location problem and a vehicle allocation problem. A set covering model is modified to solve the location problem while a simulation is used to solve the allocation problem. Combining these two models provides a powerful methodology for systematically finding a satisfactory solution to the ambulance location problem.
Evaluation and Modification of a Domeless Net Radiometer

The use of net radiation as a critical variable in models of surface-atmosphere exchange is routine; however, its measurement is not. The discrete measurement of incoming and outgoing solar radiation with pyranometers and long-wave radiation with pyrgeometers is widely thought to be the most accurate method for estimating net radiation, but deployment at multiple sites is cost prohibitive. A recently developed single-sensor net radiometer differs from other commonly used net radiometers in that it has no domes covering the thermopile sensor. Long-term field data from this net radiometer were compared to reference net radiation calculated as the sum of the four independently measured components. The domeless net radiometer agreed well with the reference measurements, out-performing a similarly priced, widely used, domed net radiometer under most conditions. However, our analyses suggest that the domeless net radiometer has differing sensitivities to short and long-wave radiation, which is not accounted for in the calibration. Additionally, precipitation affected the domeless net radiometer much more severely than the domed model, which could be a significant limitation in areas with frequent rainfall. Despite these shortfalls, the domeless net radiometer evaluated here could be useful in a variety of field settings.
Laguerre-model blind system identification: cardiovascular dynamics estimated from multiple peripheral circulatory signals

This paper presents a method for comparing multiple circulatory waveforms measured at different locations to improve cardiovascular parameter estimation from these signals. The method identifies the distinct vascular dynamics that shape each waveform signal, and estimates the common cardiac flow input shared by them. This signal-processing algorithm uses the Laguerre function series expansion for modeling the hemodynamics of each arterial branch, and identifies unknown parameters in these models from peripheral waveforms using multichannel blind system identification. An effective technique for determining the Laguerre base pole is developed, so that the Laguerre expansion captures and quickly converges to the intrinsic arterial dynamics observed in the two circulatory signals. Furthermore, a novel deconvolution method is developed in order to stably invert the identified dynamic models for estimating the cardiac output (CO) waveform from peripheral pressure waveforms. The method is applied to experimental swine data. A mean error of less than 5% with the measured peripheral pressure waveforms has been achieved using the models and excellent agreement between the estimated CO waveforms and the gold standard measurements have been obtained.
Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis

Squamous esophageal epithelium adapts to acid reflux-mediated injury by proliferation and differentiation via signal transduction pathways. Induction of the Wnt antagonist Dickkopf-1 (Dkk1) is involved in tissue repair during inflammation and cellular injury. In this study, we aimed to identify the biological role of Dkk1 in human reflux esophagitis with respect to cell growth and regulation of Wnt signaling. Esophageal biopsies from reflux-esophagitis patients (n = 15) and healthy individuals (n = 10) were characterized in terms of Dkk1 expression. The role of Dkk1 in response to acid-mediated epithelial injury was analyzed by cellular assays in vitro utilizing squamous esophageal epithelial cell lines (EPC1-hTERT, EPC2-hTERT, and HEEC). Dkk1 was significantly overexpressed in human reflux-esophagitis tissue compared with healthy esophageal mucosa at transcriptional and translational levels. After acute and chronic acid (pH 4) exposure, esophageal squamous epithelial cell lines expressed and secreted high levels of Dkk1 in response to stress-associated DNA injury. High extracellular levels of human recombinant Dkk1 inhibited epithelial cell growth and induced cellular senescence in vitro, as demonstrated by reduced cell proliferation, G0/G1 cell cycle arrest, elevated senescence-associated β-galactosidase activity, and upregulation of p16. Acid pulsing induced Dkk1-mediated senescence, which was directly linked to the ability of Dkk1 to antagonize the canonical Wnt/β-catenin signaling. In healthy esophageal mucosa, Dkk1 expression was associated with low expression of transcriptionally active β-catenin, while in reflux-esophagitis tissue, Dkk1 overexpression correlated with increased senescence-associated β-galactosidase activity and p16 upregulation. The data indicate that, in human reflux esophagitis, Dkk1 functions as a secreted growth inhibitor by suppressing Wnt/β-catenin signaling and promoting cellular senescence. These findings suggest a significant role for Dkk1 and cellular senescence in esophageal tissue homeostasis during reflux esophagitis.
THE SELVES AND THE SHOEMAKER: PSYCHOPATHS, MORAL JUDGMENT, AND RESPONSIBILITY

David Shoemaker argues from (a) psychopaths' emotional deficiency, to (b) their insensitivity to moral reasons, to (c) their lack of moral responsibility. This response observes three important ambiguities in his argument, involving the interpretation of (1) psychopaths' emotional deficit, (2) their insensitivity to reasons, and (3) their moral judgments. Resolving these ambiguities presents Shoemaker with a dilemma: his argument either equivocates or it is falsified by the empirical evidence. I then propose an alternative perspective on psychopaths' moral and criminal responsibility.
A low power 10 Gb/s serial link transmitter in 90-nm CMOS

A 10Gb/s half-rate serial link differential transmitter is optimized for low power and features a 4:1 multiplexer and a 4-tap feed-forward equalizer. The chip is error-free at 10Gb/s (231-1 PRBS) and 125/spl deg/C, driving an AC-coupled 100 Ohm differential load with a 0.9V peak-to-peak differential (ppd) signal and consuming a total of 174mW (80mA from a 1.65V supply in the output driver section and 35mA from 1.2V in the multiplexer section).
Interactions between proteins encoded within the human cytomegalovirus UL133-UL138 locus

We previously described a novel genetic locus within the ULb' region of the human cytomegalovirus (HCMV) genome that, while dispensable for replication in fibroblasts, suppresses replication in hematopoietic progenitors and augments replication in endothelial cells. This locus, referred to as the UL133-UL138 locus, encodes four proteins, pUL133, pUL135, pUL136, and pUL138. In this work, we have mapped the interactions among these proteins. An analysis of all pairwise interactions during transient expression revealed a robust interaction between pUL133 and pUL138. Potential interactions between pUL136 and both pUL133 and pUL138 were also revealed. In addition, each of the UL133-UL138 locus proteins self-associated, suggesting a potential to form higher-order homomeric complexes. As both pUL133 and pUL138 function in promoting viral latency in CD34(+) hematopoietic progenitor cells (HPCs) infected in vitro, we further focused on this interaction. pUL133 and pUL138 are the predominant complex detected when all proteins are expressed together and require no other proteins in the locus for their association. During infection, the interaction between pUL133 and pUL138 or pUL136 can be detected. A recombinant virus that fails to express both pUL133 and pUL138 exhibited a latency phenotype similar to that of viruses that fail to express either pUL133 or pUL138, indicating that these proteins function cooperatively in latency and do not have independent functions that additively contribute to HCMV latency. These studies identify protein interactions among proteins encoded by the UL133-UL138 locus and demonstrate an important interaction impacting the outcome of HCMV infection.
Stress computed tomography analysis of the distal radioulnar joint: a diagnostic tool for determining translational motion.

Sixteen distal radioulnar joints in eight normal volunteers (five females, three males) were evaluated by use of a special stress computed tomography technique. The mean palmar and dorsal translational motion was 2.2 millimeters ± 1.6 and 1.0 millimeters ± 0.9, respectively, for the combined group. The mean stress range was 3.3 millimeters ± 1.4 for the entire group. There was no statistical difference for the amount of motion noted on palmar stress, dorsal stress, and the stress-range between males and females. There was also no statistical difference between contralateral sides and hand dominance. The average contralateral difference was 0.1 millimeters, 0.1 millimeters, and 0.3 millimeters for palmar, no stress, dorsal studies, respectively. We conclude the limits of maximal translational motion of the distal radioulnar joints can be determined by computed tomography stress analysis. Unilateral analysis allows the determination of frank instability. However, bilateral analysis allows the determination of frank instability, subluxation, and dynamic instability. This technique is useful in evaluating distal radioulnar joint stability.
Warrior Spirit: Soul Wound and Coping Among American Indians in Law Enforcement

This qualitative, exploratory study examined the role vocation played for American Indian non-Tribal law enforcement officers in adaptively coping with historical trauma, or Soul Wound. Participants’ views of career in relationship to its perceived congruence with their Nations’ warrior societies and how this vocation may facilitate or constrain the management of Soul Wound or historical trauma issues was examined. For this study, 12 participants were interviewed and data were analyzed utilizing extended case method. Results indicated 11 of the 12 participants believed their vocation was congruent with their Nations’ traditional warrior roles, particularly related to the role’s value of mentorship and modeling well-living for the community. Participants’ interests and satisfaction, as well as facilitating and constraining factors of their roles, are discussed. The authors elaborate on existing theoretical understandings of Soul Wound and coping using the results. Limitations, implications, and future dire...
The Comparative Toxicogenomics Database: update 2013

The Comparative Toxicogenomics Database (CTD; http://ctdbase.org/) provides information about interactions between environmental chemicals and gene products and their relationships to diseases. Chemical-gene, chemical-disease and gene-disease interactions manually curated from the literature are integrated to generate expanded networks and predict many novel associations between different data types. CTD now contains over 15 million toxicogenomic relationships. To navigate this sea of data, we added several new features, including DiseaseComps (which finds comparable diseases that share toxicogenomic profiles), statistical scoring for inferred gene-disease and pathway-chemical relationships, filtering options for several tools to refine user analysis and our new Gene Set Enricher (which provides biological annotations that are enriched for gene sets). To improve data visualization, we added a Cytoscape Web view to our ChemComps feature, included color-coded interactions and created a 'slim list' for our MEDIC disease vocabulary (allowing diseases to be grouped for meta-analysis, visualization and better data management). CTD continues to promote interoperability with external databases by providing content and cross-links to their sites. Together, this wealth of expanded chemical-gene-disease data, combined with novel ways to analyze and view content, continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases.
Proactive wrangling: mixed-initiative end-user programming of data transformation scripts

Analysts regularly wrangle data into a form suitable for computational tools through a tedious process that delays more substantive analysis. While interactive tools can assist data transformation, analysts must still conceptualize the desired output state, formulate a transformation strategy, and specify complex transforms. We present a model to proactively suggest data transforms which map input data to a relational format expected by analysis tools. To guide search through the space of transforms, we propose a metric that scores tables according to type homogeneity, sparsity and the presence of delimiters. When compared to "ideal" hand-crafted transformations, our model suggests over half of the needed steps; in these cases the top-ranked suggestion is preferred 77% of the time. User study results indicate that suggestions produced by our model can assist analysts' transformation tasks, but that users do not always value proactive assistance, instead preferring to maintain the initiative. We discuss some implications of these results for mixed-initiative interfaces.
Estimating the Reliability of Aggregate-Level Variables Based on Individual-Level Characteristics

Social scientists often use the mean of individual-level characteristics to describe aggregates such as organizations, schools, or programs. They seldom, however, attempt to assess the reliability of these measures. This article indicates how the internal consistency reliability of such measures can be estimated for several commonly used research designs. The method is based on generalizability theory and requires only the data that would normally be used to answer the substantive questions of a study; for example retests or parallel forms are not necessary.
Gene Expression Analysis of Toll-Like Receptor Pathways in Heterophils from Genetic Chicken Lines that Differ in Their Susceptibility to Salmonella enteritidis

Previously conducted studies using two chicken lines (A and B) show that line A birds have increased resistance to a number of bacterial and protozoan challenges and that het- erophils isolated from line A birds are functionally more responsive. Furthermore, when stimulated withToll-like receptor (TLR) agonists, heterophils from line A expressed a totally different cytokine and chemokine mRNA expression pattern than heterophils from line B. A large-scale gene expression profile using an Agilent 44K microarray on heterophils isolated from line A and line B also revealed significantly differential expression in many immune-related genes following Salmonella enteritidis (SE) stimulation, which included genes involved in the TLR pathway. Therefore, we hypothesize the differences between the lines result from distinctive TLR pathway signaling cascades that mediate heterophil function and, thus, innate immune responsiveness to SE. Using quantitative RT-PCR on mRNA from heterophils isolated from control and SE-stimulated heterophils of each line, we profiled the expression of all chicken homologous genes identified in a reference TLR pathway. Several differentially expressed genes found were involved in the TLR-induced My88-dependent pathway, showing higher gene expression in line A than line B heterophils following SE stimulation. These genes included the TLR genes TLR4, TLR15, TLR21, MD-2, the adaptor proteins Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP ), Tumor necrosis factor-receptor associated factor 3 (TRAF3), the IkB kinases transforming growth factor-b-activating kinase 1 (TAK1), IKK+ and IKKa, the transcription factors NFkB2 and interferon regulatory factor 7, phosphatidylinositol-3 kinase (PI-3K ), and the mitogen- activated protein kinase p38. These results indicate that higher expression of TLR signaling activation of both MyD88-dependent and TRIF-dependent pathways are more beneficial to avian heterophil-mediated innate immunity and a complicated regulation of downstream adaptors is involved in stronger induction of a TLR-mediated innate response in the resis- tant line A.These findings identify new targets for genetic selection of chickens to increase resistance to bacterial infections.
TACS enhancements for the Electromagnetic Transient Program

Transient analysis of control systems (TACS) of the electromagnetic transient program (EMTP) has been enhanced in many ways. There are major changes in methods of ordering components to minimize the introduction of time step and history term errors. Initialization algorithms have been greatly enhanced to allow multiple frequency initialization. An "IF THEN ELSE" control structure and the use of user written FORTRAN routines are among the important new features available to users of TACS. >
Modification of Radiation Response of Murine Tumors by Misonidazole (Ro 07-0582), Host Immune Capability, and Corynebacterium parvum

The hypoxic cell sensitizer misonidazole (Ro 07-0582),1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol, significantly enhanced the local control of the weakly immunogenic C3H mouse mammary carcinoma MDAH-MCa-4 (8-mm diameter) by single doses of radiation. The dose modification factor (DMF) was 2.33 when the drug was given ip to inbred C3Hf/Bu mice in a dose of 1 mg/g body weight 30 minutes before irradiation of the tumor. The DMF in a highly immunogenic 3-methylcholanthrene-induced C3H fibrosarcoma (FSa) was 1.65 in normal mice and 1.86 in mice immunosuppressed by 600 rads whole-body irradiation 1 day before tumor transplantation. In mice treated iv with 0.25 mg Corynebacterium parvum when tumors were 6 mm in diameter and irradiated at 8 mm, local control of FSa was enhanced at low doses of radiation but was similar to that in normal mice at higher doses. In mice treated with both misonidazole and C. parvum, local control at lower doses of radiation was similar to that in mice treated with C. parvum alone but was enhanced at higher doses in mice that failed to respond to C. parvum. Cytotoxicity of misonidazole, as reflected in tumor growth, was not detected.
BASS: approximate search on large string databases

In this paper, we study the problem on how to build an index structure for large string databases to efficiently support various types of string matching without the necessity of mapping the substrings to a numerical space (e.g., string B-tree and MRS-index) nor the restriction of in-memory practice (e.g., suffix tree and suffix array). Towards this goal, we propose a new indexing scheme, BASS-tree, to efficiently support general approximate substring match (in terms of certain symbol substitutions and misalignments) in sublinear time on a large string database. The key idea behind the design is that all positions in each string are grouped recursively into a fully balanced tree according to the similarities of the subsequent segments starting at those positions. Each node is labeled with a regular expression that describes the commonality of the substrings indexed through the subtree. Any search can then be properly directed to the portion in the database with a high potential of matching quickly. With the BASS-tree in place, wild card(s) in the query pattern can also be handled in a seamless way. In addition, search of a long pattern can be decomposed into a series of searches of short segments followed by a process to join the results. It has been demonstrated in our experiments that the potential performance improvement brought by BASS-tree is in an order of magnitude over alternative methods.
Prognostic value of automated vs visual analysis for adenosine stress myocardial perfusion SPECT in patients without prior coronary artery disease: A case-control study

Purpose We aimed to evaluate the prognostic value of automated quantitative hypoperfusion parameters derived from adenosine stress myocardial perfusion SPECT (MPS) for predicting sudden or cardiac death (CD) in case-controlled patients with suspected coronary artery disease (CAD).
1,4-dicyanobenzene as a scaffold for the preparation of bimetallic actinide complexes exhibiting metal-metal communication.

Reaction of two equivalents of [(C 5 [e 4 Et)2U(CH3)(Cl)] (6) or [(C 5 Me 5 ) 2 Th(CH 3 )(Br)] (7) with 1,4-dicyanobenzene leads to the formation of the novel 1,4-phenylenediketimide-bridged bimetallic organoactinide complexes [{(C5Me4Et)2(Cl)U}2(μ-{N=C-(CH3)-C 6 H 4 -(CH3)C=N})] (8) and [{(C 5 Me 5 -) 2 (Br)Th} 2 ,(μ-{N=C(CH 3 )-QH4-(CH 3 )CmN))] (9), respectively. These complexes were structurally characterized by single-crystal X-ray diffraction and NMR spectroscopy. Metal-metal interactions in these isovalent bimetallic systems were assessed by means of cyclic voltammetry, UV-visible/NIR absorption spectroscopy, and variable-temperature magnetic susceptibility. Although evidence for magnetic coupling between metal centers in the bimetallic U IV /U IV (5f 2 -5f 2 ) complex is ambiguous, the complex displays appreciable electronic communication between the metal centers through the π system of the dianionic diketimide bridging ligand, as judged by voltammetry. The transition intensities of the f-f bands for the bimetallic U IV /U IV system decrease substantially compared to the related monometallic ketimide chloride complex, [(C 5 Me 5 ) 2 U(Cl){-N= C(CH3)-(3,4,5-F 3 -C 6 H 2 ))] (11). Also reported herein are new synthetic routes to the actinide starting materials [(C5Me4Et)2U(CH3)(Cl)] (6) and [(C 5 Me 5 ) 2 Th(CH 3 )(Br)] (7) in addition to the syntheses and structures of the monometallic uranium complexes [(C 5 Me 4 Et) 2 UCl 2 ] (3), [(C 5 Me 4 Et) 2 U-(CH 3 ) 2 ) (4), [(C 5 Me 4 Et)2U(-N=C(CH3)-C 6 H 4 -C=N) 2 ) (10), and 11.
Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells

STUDY QUESTION Can biologically active vitamin D3 [1,25(OH)2D3] regulate the expression and activity of matrix metalloproteinases (MMPs) in human uterine fibroid cells?
The Quest For Molecule-Based Magnets

In the past decade a new class of magnets possessing spins on organic species have been discovered and studied. These magnets can be fabricated at room temperature and may enable useful devices and/or processes. Herein we discuss several of the mechanisms that can enable the stabilization of magnetic ordering and also provide examples of molecule-based magnets.
Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA.

Group II introns encode reverse transcriptases that function in both intron mobility and RNA splicing. The proteins bind specifically to unspliced precursor RNA to promote splicing, and then remain associated with the excised intron to form a DNA endonuclease that mediates intron mobility by target DNA-primed reverse transcription. Here, immunoblotting and UV cross-linking experiments show that the reverse transcriptase activity encoded by the yeast mtDNA group II intron aI2 is associated with an intron-encoded protein of 62 kDa (p62). p62 is bound tightly to endogenous RNAs in mitochondrial ribonucleoprotein particles, and the reverse transcriptase activity is rapidly and irreversibly lost when the protein is released from the endogenous RNAs by RNase digestion. Non-denaturing gel electrophoresis and activity assays show that the aI2 reverse transcriptase is associated predominantly with the excised intron RNA, while a smaller amount is associated with unspliced precursor RNA, as expected from the role of the protein in RNA splicing. Although the reverse transcriptase in wild-type yeast strains is bound tightly to endogenous RNAs, it is regulated so that it does not copy these RNAs unless a suitable DNA oligonucleotide primer or DNA target site is provided. Certain mutations in the intron-encoded protein or RNA circumvent this regulation and activate reverse transcription of endogenous RNAs in the absence of added primer. Although p62 is bound to unspliced precursor RNA in position to initiate cDNA synthesis in the 3' exon, the major template for target DNA-primed reverse transcription in vitro is the reverse-spliced intron RNA, as found previously for aI1. Together, our results show that binding to intron-containing RNAs stabilizes and regulates the activity of p62.
The role of cytochrome P450 BM3 phenylalanine-87 and threonine-268 in binding organic hydroperoxides.

Abstract Background Cytochrome P450 (P450) BM3, from Bacillus megaterium, catalyzes a wide range of chemical reactions and is routinely used as a model system to study mammalian P450 reactions and structure. Methods The metabolism of 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone (BHTOOH) and 2-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadien-1-one (BMPOOH) was examined with P450 BM3 and with the conserved T268 and F87 residues mutated to investigate their effects on organic hydroperoxide metabolism. To determine the effects of the mutations on the active site volume and architecture, the X-ray crystal structure of the F87A/T268A P450 BM3 heme domain (BMP) was determined and compared to previous structures. To investigate the interactions of the substrates with the F87 and T268 residues, BHTOOH and BMPOOH were docked into the BMP X-ray crystal structures. Results Lower metabolism of BHTOOH and BMPOOH was observed in the WT P450 BM3 and the T268A P450 BM3 mutant than in the F87A and F87A/T268A P450 BM3 mutants. Large differences were found in the F–G loop regions and active site cavity volumes for the F87A mutated structures. Conclusions Analysis of the metabolism, X-ray crystal structures, and molecular docking simulations suggests that P450 BM3 activity toward BHTOOH and BMPOOH is mediated through substrate recognition by T268 and F87, and the active site cavity volume. Based on this information, a simplified representation is presented with the relative orientation of organic hydroperoxides in the P450 BM3 active site. General significance The metabolism results and structural analysis of this model P450 allowed us to rationalize the structural factors that influence organic hydroperoxide metabolism.
Mobile medical apps: To regulate, or not to regulate?

Hundreds, if not thousands, of mobile medical apps (MMAs) are available with an easy touch of a screen, promising anything from all-encompassing diagnoses and foolproof diet, medication, and exercise plans to turning your phone into a personal blood pressure monitor or disease tracker.
The Efficacy of IRIS STAR Legacy Modules Under Different Instructional Conditions

The vast majority of special education teacher preparation programs in the United States incorporate the IRIS Center’s STAR Legacy modules into their coursework. Given the diversity of module conte...
Who is Next? Identifying Communities with the Potential for Increased Implementation of Sustainability Policies and Programs

Understanding the system of connections between societal contexts and policy outcomes in municipal governments provides important insights into how community sustainability happens, and why it happens differently in various communities. A growing body of research in recent years has focused on understanding the socio-economic characteristics of communities and cities that are recognized as policy leaders in sustainability. In this paper, we expand the focus beyond the leaders in sustainability as we apply a selection of socio-demographic influences of community sustainability to a large sample of U.S. communities using community classification analytics to identity a range of community types and levels of engagement with sustainability. Our typology presents an integrated and comprehensive perspective on the structure of community sustainability in the United States, highlighting key points of comparison between human capital factors such as population size and density, affluence, home ownership, and adoption of sustainability policy. The analysis provides new insights not only about community leaders in sustainability, but also communities with the civic and social capacity to do more, and the challenges that may inhibit sustainability efforts in others.
Managing Care of an Intrapartum Patient with Agitation and Psychosis: Ethical and Legal Implications.

The best interests of a pregnant psychotic patient can be served by determining her decision making capacity and using surrogate decision making if needed.
Opening the news gates? Humanitarian and human rights NGOs in the US news media, 1990–2010

This study examines whether changes in the media, political, and civic landscapes give leading non-governmental organizations (NGOs) increased news access. Using longitudinal content analysis (1990–2010) of a purposive sample of US news outlets, it compares the prevalence, prominence, and story location of news articles citing leading human rights NGOs to human rights coverage more generally. In all outlets, NGO prevalence rises over time; media-savvy NGOs drive much of the growth. By contrast, prominence decreases, as do the number of NGO-driven stories. In all outlets, NGOs typically appear in stories already in the media spotlight; as sources, they appear after the statements of government officials. Finally, the news outlets most receptive to NGOs are those that commit the fewest resources to international news coverage. Overall, findings suggest that while NGO news access has indeed increased over time, such access continues to be shaped by established patterns of news construction.
Chemical Vapor Deposition of Oxides From Alkoxides

MOCVD of oxides can be achieved through deposition reaction schemes such as oxidation, thermal pyrolysis, plasma assisted pyrolysis, radiation-assisted pyrolysis or any combinations of these free-radical processes. Chemically mild and clean reaction schemes such as the hydrolysis-polycondensation and the hydrolysis-assisted pyrolysis reactions are found favorable for stoichiometric depositions using alkoxide complex precursors. We review the various reaction schemes and try to point out comparatively the advantages and disadvantages of each. Experiments in the deposition of lithium tantalate from alkoxide complex precursors are presented. Low deposition temperature, high deposition rate and autostoichiometry capabilities are demonstrated in the experiments.
Improving Patient Safety through Educational Initiatives

The VA National Center for Patient Safety (NCPS) came into being just prior to publication of the IOM Report (Kohn, 1999). From the outset, the approach used by NCPS was to seek engineering solutions (Watts, 2012). Human factors engineering (HFE) adds the necessary insight for solving complex patient safety issues (Bagian, 2012; Gurses, 2012). For NCPS, the initial step was development of a specialized professional role, a Patient Safety Manager, employed at every VA hospital [Bagian, 2002]. A second effort, detailed here, is specifically focused on filling a patient safety leadership gap. Clinician-leaders become patient safety leaders as they acquire knowledge and skills in teamwork, communication, and other HFE-based methods for problem-solving.
Factors affecting the quantitative evaluation of the uni- and bidirectional reactions of mixed leukocyte cultures.

There is evidence to support the opinion that the unidirectional mixed leukocyte reaction is a reliable procedure for assessing histocompatibility in humans. If the test is to be useful for comparing degrees of histocompatibility among a given population, the technic must be standardized by giving careful attention to the factors which influence the degree of reactivity of cells in culture. We found that to obtain the maximum reactivity two factors are important: (1) the length of incubation, since the maximum reactivity occurred on days 6, 7, or 8, but did not always occur on the same day, and (2) the time of incubation with isotopically-labelled thymidine, which is maximum in mixed leukocyte cultures in 18 to 24 hr. To compare degrees of histocompatibility, the cultures should be standardized by the number of lymphocytes. In our system, two factors do not influence the reaction: the concentrating of lymphocytes in the cultures to 93 to 96% in the presence of 1.1% or more macrophages, and the increase in the number of stimulating lymphocytes, provided the volume of each culture is kept at 4 ml.
Yes We Can (Channel Our Arousal): The Adaptive Role of Cortisol in Women’s Salary Negotiations

Women have been found to experience more stress than men in negotiations which can adversely affect negotiation outcomes. However, it has been suggested that certain behavioral practices, such as b...
Searching for Significance in Unstructured Data: Text Mining with Leximancer:

Scholars in many knowledge domains rely on sophisticated information technologies to search for and retrieve records and publications pertinent to their research interests. But what is a scholar to...
The application of the phage-fluorescent antiphage staining system in the specific identification of Listeria monocytogenes. II. The use of the phage-fluorescent antiphage system in the specific identification of Listeria monocytogenes in tissues from experimentally infected animals.

Smith et al (1962) and Smith and Metzger (1963) used a polyvalent conjugated fluorescent antiserum in the specific demonstration of the 4 serological types of Listeria monocytogenes in experimentally infected animal tissue. Listerial antigens were stable to fixation in formalin, embedding in paraffin, and subsequent deparaffinization with organic solvents. Although the immunofluorescent technique was not without limitations when employed in the detection of tissue-associated L. monocytogenes, it provided a rapid method for demonstrating this pathogen in surgical and autopsy material (Villella et al, 1963; Biegeleisen, 1964). Duncan and Olson (1963) traced the fate of intravenously injected L. monocytogenes in guinea pigs by examining frozen tissue culture sections with cultural and
Research of on Big Data and its Application Scenarios in Grid Intelligent Dispatching Field

With the widespread access of distributed energy resources wind,light storage and other new energy sources,power dispatching has involved massive,multi-type,high complexity of the data,Transforming transforming power data into knowledge is the inevitable trend of intelligent scheduling dispatching development.For application of to meet the requirements to of deep and overall comprehensive big data analysis,this paper analyses and summaries data in intelligent dispatching field according to from the data sources,data characteristics,application trend and etc,considering intelligent scheduling new requirements of intelligent dispatching,analyzes potential application scenarios of big data technology in the field of intelligent dispatching,to provides a reference of realizing intelligent analysis and decision making with comprehensive optimal objectives of accuracy,security,economic and others,which single data source can not be achieved by single data source.
Breeding and Application of New Strong Heterosis Hybrid Rice Combination Liangyou 1128

Liangyou 1128,derived from the cross between P88S,a dual-purpose genic male sterile line,and R1128,is a new two-line hybrid rice combination developed by Hunan Hybrid Rice Research Center.It has the characteristics of high and stable yield,good plant type,relatively good grain quality and strong lodging resistance.It was approved for release by Hunan Provincial Crop Variety Appraisal Committee in March,2011.
IMPLICIT FUNCTIONS AND DIFFERENTIATION

This chapter describes implicit functions and implicit differentiation. Not every equation, even of polynomial type, can be solved directly for its unknown. If two variables are related by an equation that cannot be solved algebraically for one of the variables, then one can only discover the relationship between the two variables numerically. To be specific, if X and Y are related by the equation Y↑2 + 3 * X * Y − 6 * X↑3 * Y = 5, then by treating this as a quadratic in Y and applying the quadratic formula, one has Y = (-3 * X + -SQR(9 * X↑2 + 4 * (5 + 6 * X↑3)))/2. Thus, in this case, one is able to solve the equation relating X and Y to obtain an explicit relationship between the two variables. If the polynomial relating X and Y had been of degree 5 or greater in both of the variables, then it would in general be impossible to obtain an explicit relationship between the two variables. In that case, the relationship can be called implicit.
A Whole Blood Assay for AR-V7 and ARv567es in Patients with Prostate Cancer

Purpose: Most prostate cancer mortality can be attributed to metastatic castration resistant prostate cancer, an advanced stage that remains incurable despite recent advances. The AR (androgen receptor) signaling axis remains active in castration resistant prostate cancer. Recent studies suggest that expression of the AR-V (AR splice variant) AR-V7 may underlie resistance to abiraterone and enzalutamide. However, controversy exists over the optimal assay. Our objective was to develop a fast and sensitive assay for AR-Vs in patients.Materials and Methods: Two approaches were assessed in this study. The first approach was based on depletion of leukocytes and the second one used RNA purified directly from whole blood preserved in PAXgene® tubes. Transcript expression was analyzed by quantitative reverse transcription-polymerase chain reaction.Results: Through a side-by-side comparison we found that the whole blood approach was suitable to detect AR-Vs. The specificity of the assay was corroborated in a cance...
‘On the Line’: a report on shifting collaborations around clotheslines

AbstractThis vignette tells the story of ‘On the Line’, a Riverside, California series of exhibitions, performances, research and participatory interventions that focus on clotheslines to probe divisions of life and art, gender and culture and generation. Who does your laundry? What does an electric dryer indicate about changing relationships to nature? How do movements and conversations around laundry lines differ across the world? Each event has associated art and ethnography differently, building on earlier work to develop varied modes of spectatorship, participation, research and dialogue. The programme started with my work: first a painting, then in 2013 the first ‘On the Line’ exhibition. Artists, anthropologists and graduate students developed a ‘critique’ and then a ‘remake’ of that exhibition called ‘On the Line: A Second look’. The circle of collaborative research and practice widened and produced ‘Hanging Out’ in 2015. That exhibition was developed as a site for fieldwork, collaboration and per...