cssi/SciSciGPT-SciSciNet huggingface dataset:
Magnetization and magnetic entropy of Dy2Ti2O7

Isothermal measurements of the magnetic entropy, magnetization, and differential susceptibility of Dy2Ti2O7 have been made. Absolute values of magnetic entropy have been determined as a function of applied magnetic field for several temperatures in the range 2-20 K, and several isofield lines in the magnetic entropy-temperature plane have been determined. Magnetization measurements, which extended into the saturation region, yield a powder-average magnetic moment of about 4.7 Bohr magnetons per ion. A van Vleck contribution to M was also observed. The results are consistent with the assumption of a nearly pure Jz equals + or - 15/2 ground-state Kramers doublet for the Dy(+++) ion. Comments on the suitability of Dy2Ti2O7 for use in a magnetic refrigerator cycling between 4.2 and 20 K are included.
Sedative Dosing Of Propofol For Treatment Of Migraine Headache In The Emergency Department: A Case Series

Introduction: Migraine headaches requiring an emergency department visit due to failed outpatient rescue therapy present a significant challenge in terms of length of stay (LOS) and financial costs. Propofol therapy may be effective at pain reduction and reduce that length of stay given its pharmacokinetic properties as a short acting intravenous sedative anesthetic and pharmacodynamics on GABA mediated chloride flux. Methods: Case series of 4 patients presenting to an urban academic medical center with migraine headache failing outpatient therapy. Each patient was given a sedation dose (1 mg/kg) of propofol under standard procedural sedation precautions. Results: Each of the 4 patients experienced dramatic reductions or complete resolution of headache severity. LOS for 3 of the 4 patients was 50% less than the average LOS for patients with similar chief complaints to our emergency department. 1 patient required further treatment with standard therapy but had a significant reduction in pain and a shorter LOS. There were no episodes of hypotension, hypoxia, or apnea during the sedations. Conclusion: In this small case series, sedation dose propofol appears to be effective and safe for the treatment of refractory migraines, and may result in a reduced LOS. (West J Emerg Med. 2013;14(6):646-649.)
DUST DYNAMICS, SURFACE BRIGHTNESS PROFILES, AND THERMAL SPECTRA OF DEBRIS DISKS: THE CASE OF AU MICROSCOPII

AU Microscopii is a 12 Myr old M dwarf that harbors an optically thin, edge-on disk of dust. The scattered light surface brightness falls with projected distance b from the star as b-α; within b = 43 AU, α ≈ 1-2, while outside 43 AU, α ≈ 4-5. We devise a theory to explain this profile. At a stellocentric distance r = rBR = 43 AU, we posit a ring of parent bodies on circular orbits: the ``birth ring,'' wherein micron-sized grains are born from the collisional attrition of parent bodies. The ``inner disk'' at r rBR comprises grains just large enough to remain bound to the star, on orbits rendered highly eccentric by stellar wind and radiation pressure. How the vertical optical depth τ⊥ scales with r depends on the fraction of grains that migrate inward by CPR drag without suffering a collision. If this fraction is large, the inner disk and birth ring share the same optical depth, and τ⊥ r-5/2 in the outer disk. By contrast, under collision-dominated conditions, the inner disk is empty, and τ⊥ r-3/2 outside. These scaling relations, which we derive analytically and confirm numerically, are robust against uncertainties in the grain size distribution. By simultaneously modeling the surface brightness and thermal spectrum, we break model degeneracies to establish that the AU Mic system is collision dominated and that its narrow birth ring contains a lunar mass of decimeter-sized bodies. The inner disk is devoid of micron-sized grains; the surface brightness at b 43 AU arises from light forward scattered by the birth ring. Inside b = 43 AU, the disk's V - H color should not vary with b; outside, the disk must become bluer as ever smaller grains are probed.
Highly acidic C-terminal region of cytomegalovirus pUL96 determines its functions during virus maturation independently of a direct pp150 interaction.

ABSTRACT Tegument proteins pp150 and pUL96 function at a late step in cytomegalovirus (CMV) maturation. Here, we show that pp150 interacts directly with pUL96; however, the N-terminal region of pp150 and the C-terminal region of pUL96, which are critical for these proteins to function, are not required for this interaction. Moreover, the largely dispensable C-terminal region of pp150 is critical for pp150-pUL96 interaction. To further study the role of pUL96, several point and clustered mutations were engineered into the CMV Towne bacterial artificial chromosome (Towne-BAC) genome, replacing the conserved negatively charged C-terminal residues of pUL96. Although individual point mutations (E 122 A, D 124 A, and D 125 A) reduced virus growth slightly, the clustered mutations of 122 EVDDAV 127 significantly reduced virus growth, produced small syncytial plaque phenotypes, and impacted a late stage of virus maturation. When the UL96 C-terminal alanine conversion mutant (B6-BAC) virus was serially passaged in cell culture, it gained a plaque size comparable to that of Towne-BAC, displayed an altered restriction fragment length pattern, and replicated with increased growth kinetics. Whole-genome sequencing of this passaged virus (UL96P10) and the similarly passaged Towne-BAC virus revealed major differences only in the RNA4.9 and UL96 regions. When one of the mutations in the UL96 coding region was engineered into the B6-BAC virus, it significantly increased the plaque size and rescued the virus growth rate. Thus, accumulation of compensatory mutations only in UL96 in this revertant and the specific involvement of functionally dispensable regions of pp150 in the pUL96-pp150 interaction point toward a role for pUL96 in virus maturation that does not depend upon pp150. IMPORTANCE Human cytomegalovirus causes significant medical problems in newborns, as well as in people with low immunity. In this study, we investigated the functions of two essential virus proteins, pp150 and pUL96, and determined the impact of their mutual interaction on virus replication. These studies provide valuable information that is critical for the development of targeted antiviral therapies.
Gastroduodenal arterial aneurysms: Report of a case and review of the literature

Aneurysms of the gastroduodenal artery are rare. Only nine cases have been reported previously. These aneurysms are extremely difficult to diagnose preoperatively. A case of ruptured gastroduodenal artery aneurysm, which was diagnosed by aortography prior to operation, is reported, and the literature is reviewed.
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans

Background— Resistin, a plasma protein, induces insulin resistance in rodents. Recent reports suggest that circulating levels of resistin are elevated in obese and insulin-resistant rodents and humans. Whereas rodent resistin is made in adipocytes, macrophages are a major source of human resistin. Given the convergence of adipocyte and macrophage function, resistin may provide unique insight into links between obesity, inflammation, and atherosclerosis in humans. Methods and Results— We examined whether plasma resistin levels were associated with metabolic and inflammatory markers, as well as with coronary artery calcification (CAC), a quantitative index of atherosclerosis, in 879 asymptomatic subjects in the Study of Inherited Risk of Coronary Atherosclerosis. Resistin levels were positively associated with levels of inflammatory markers, including soluble tumor necrosis factor-α receptor-2 (P<0.001), interleukin-6 (P=0.04), and lipoprotein-associated phospholipase A2 (P=0.002), but not measures of insul...
Property Tax Assessment Practice and Income Elasticities

The routines of property tax assessment practiced by state and local governments differ dramatically among jurisdictions. Regardless of particular routine applied (annual assessment, staggered cycl...
Application Lockbox for Mobile Device Security

The security requirements for mobile devices are inherently different from stationary machines. Mobility exposes them to different threat environments and excludes them from relying on external physical security. Productive application from enterprise, government, and military will invariably deal with sensitive data. A risk management and security framework is needed to protect applications and data on mobile devices when they are lost. We propose an application lockbox concept that compartmentalizes mobile devices at the application level. It combines policy enforcement mechanisms and support for sophisticated access polices to mitigate the exposure when the device is lost. It is a practical approach that improves the security of mobile devices without requiring significant changes in the current mobile technology.
The infant neurodevelopmental assessment: A clinical interpretive manual for CAT-CLAMS in the first two years of life, part 1*

Summary The above evaluation for minor dysmorphic features might perhaps be referred to as medical or scientific physiognomy. Physiognomy was never supposed to be limited to the study of the face, but in its better versions includes the face, the palms, the somatotype, as well as the gait and other movement patterns. Medical physiognomy therefore approximates the modern approach to syndrome identification but remains somewhat broader. The above and similar dysmorphic features may contribute to the identification of a specific chromosomal, genetic, or teratogenic syndrome diagnosis. However, the presence of several (usually taken as more than 3 or 4) of these minor malformations in the absence of a specific syndrome still suggests either a genetic influence (perhaps a constellation of familial features) or some adverse impact on the developing fetus occurring in the first trimester. The absence of a syndrome and the presence of a familial pattern of dysmorphology does not rule out an association with developmental disorders; rather they recommend a more in-depth review of the family history for the presence of subtle developmental abnormalities. In the presence of a developmental diagnosis, dysmorphic features support the need for a more detailed genetic investigation and strongly favor a prenatal as opposed to postnatal cause for the disorder. With a suspicious but nondiagnostic developmental delay, the presence of dysmorphic features favors increasing the seriousness with which an otherwise mild degree of delay is interpreted.
Transmission line modeling and synthesis for multi-channel communication

To overcome the limitations of traditional interconnects, transmission lines that transmit multi-channel signals via high frequency carriers have recently been proposed and realized for intra-chip and inter-chip communication. We derive a closed-form model for SNR for such interconnects with multiple ports and branches, and propose efficient figures of merit (FOMs) to minimize signal distortion. Experiments show that the SNR model is accurate compared to SPICE simulation and signal distortion FOMs are effective. Using the proposed models, we further automatically synthesize coplanar waveguides for radio-frequency (RF) interconnects with capacitive couplers. We minimize the total interconnect area under constraints of SNR and signal distortion. Compared to the published manual designs, the synthesized solution can reduce up to 80% area. Furthermore, the optimized solutions vary greatly with respect to number of ports, frequency bands, topologies and terminations, and therefore automatic synthesis is needed.
A new method of dream analysis congruent with contemporary counseling approaches

Dream analysis appears to deepen and accelerate the psychotherapeutic process, but it is not widely employed in modern practice. This may be due, in part, to the belief that the value of a dream lies in the analysis of its visual content, and that reflective awareness, volition, and personal responsibility––qualities valued highly by non-psychodynamic therapies––are presumed to be lacking in most dreams. While modern research has largely overturned this view, it may still impede the adoption of dream analysis by modern psychotherapists. Add to that a psychotherapist’s lack of training and concomitant discomfort with his or her own dreams and it is no surprise that dream work utilization remains low. Drawing on an array of theoretical, clinical, and empirical sources, this paper presents a view of normal dreaming as an interactive process between the dreamer and the dream imagery, and views the dream outcome as a co-determined or co-created experience. By shifting the focus in dream analysis away from content to interactive process, a counselor view the dream in such a way as to support the goals of contemporary therapy. By adopting this paradigm, he or she can assist clients in discerning the dream ego’s responses to the dream content, and evaluate how these responses influence the overall experience and, by implication, parallel waking relationships. Such an approach is congruent with the client-centered, competency-based aims of many schools of modern therapy, and thus may result in a more widespread adoption of dream analysis by psychotherapists. The author presents a case example of employing an approach to dream analysis consistent that is congruent with the goals of many of the schools of modern psychotherapy.
Barley root hair growth and morphology in soil, sand, and water solution media and relationship with nickel toxicity

Barley, Hordeum vulgare (Doyce), was grown in the 3 media of soil, hydroponic sand solution (sand), and hydroponic water solution (water) culture at the same environmental conditions for 4 d. Barley roots were scanned, and root morphology was analyzed. Plants grown in the 3 media had different root morphology and nickel (Ni) toxicity response. Root elongations and total root lengths followed the sequence soil > sand > water. Plants grown in water culture were more sensitive to Ni toxicity and had greater root hair length than those from soil and sand cultures, which increased root surface area. The unit root surface area as root surface area per centimeter of length of root followed the sequence water > sand > soil and was found to be related with root elongation. Including the unit root surface area, the difference in root elongation and 50% effective concentration were diminished, and percentage of root elongations can be improved with a root mean square error approximately 10% for plants grown in different media. Because the unit root surface area of plants in sand culture is closer to that in soil culture, the sand culture method, not water culture, is recommended for toxicity parameter estimation. Environ Toxicol Chem 2016;35:2125-2133. © 2016 SETAC.
Global Disclosure Practices of U.S. Corporations Entering Overseas Equity Markets

This study examines the global disclosure practices of U.S. companies that list equities in overseas markets. We focus on two questions: First how (if at all) do the frequency mix and timing of a firm's disclosures change in an overseas market when the firm lists equity in that market? Second after a U.S. firm has listed overseas are its disclosures in the overseas market as frequent and as timely as in the U.S.? We observe that U.S. firms listing in the U.K. and in Continental Europe do not increase the frequency of timeliness of accounting disclosures they make in Europe during the post-listing period. In contrast the private U.S. firms making initial public offerings in the U.K. and U.S. firms listing existing equity in Japan do increase disclosure frequency and timeliness. We also find that U.S. firms make fewer and less timely accounting disclosures in non-U.S. markets than in the U.S. during the post-listing period. These results suggest that since acquiring and maintaining an equity listing in the U.K. and Continental Europe is inexpensive and monitoring and enforcement of disclosure rules is not stringent U.S. firms might list in those markets even when they have little serious intention of expanding their shareholder bases or complying with the disclosure rules there. In contrast since listing equity in Japan is comparatively expensive perhaps the only firms that list in Japan are those that believe they can benefit significantly from the foreign listing and this may influence their disclosure choices.
Abstract 2541: Effect of carcinogen acrolein on DNA repair and mutagenic susceptibility.

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Lung cancer death is the number one cause of cancer death in the United States. Cigarette smoking is the major cause of lung cancer. Cigarette smoke (CS) contains more than 60 human carcinogens. Our early work has demonstrated that acrolein (Acr), one of the most abundant aldehydes in CS, reacts with DNA to form α- and α-hydroxy-1, N2-cyclic propano-dG adducts (α-Acr-dG and α-Acr-dG). The distribution of Acr-dG in the p53 gene coincides with lung cancer p53 mutational spectrum. Acr-dG adducts induce mainly G to T and G to A mutations that are similar to the mutation signature found in the p53 gene in lung cancer. We have also found that Acr inhibits DNA repair. Therefore, we concluded that Acr is a major etiological agent for CS related lung cancer. In this study, we found that Acr-dG adducts are poorly repaired in Acr treated normal human bronchial epithelial (NHBE) cells. Intriguingly, NHBE cell lysates are competent in carrying out in vitro repair synthesis assay using Acr-modified as well as UV-irradiated DNA as substrates. These results indicate that Acr treatment impairs DNA repair function. We found that Acr not only inhibits nucleotide excision repair (NER), it also inhibits base excision repair (BER) and mismatch repair (MMR). Acr does not change the expression of XPA, XPC, hOGG1, PMS2 or MLH1 genes. However, Acr causes a reduction of XPA, XPC, hOGG1, PMS2 and MLH1 proteins and that this effect can be neutralized by the proteosome inhibitor, MG132. We further found that Acr treatment enhances both bulky and oxidative DNA damage-induced mutagenesis. These results indicate that Acr not only damages DNA, but can also modify DNA repair proteins and further cause degradation of these modified repair proteins. We propose that these two detrimental effects contribute to Acr mutagenicity and carcinogenicity. ![Figure][1] Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2541. doi:1538-7445.AM2012-2541 [1]: pending:yes
Fabrication, Characterization and Electronic Properties of Bismuth Nanowire Systems

We have fabricated ultra-fine Bi nanowire (10–120 nm) arrays with packing densities as high as 7.1 × 1010/cm2 by pressure injecting its liquid melt into the evacuated nano-channels of an anodic alumina template. Using this fabrication technique, we have also prepared Te-doped n-type Bi nanowires. Free-standing Bi nanowires with an aspect ratio (length/diameter) higher than 500 are obtained by etching away the anodic alumina matrix without attacking the Bi. The resulting Bi nanowires are shown to be single crystals (with the same crystal structure as bulk Bi) and all the wires of a nanowire array are similarly oriented along the wire axis. The small electron effective mass of Bi, the high anisotropy of its Fermi surface, and the large aspect ratio of the Bi nanowires make this a very promising material for low-dimensional thermoelectric applications and an excellent system for studying quantum confinement effects in a quasi-one-dimensional (1D) electron gas. A theoretical model based on the basic band structure of bulk Bi, suitably modified for the 1D situation, is constructed to explore the electrical transport properties of Bi nanowires, which are expected to be very different from those of bulk Bi.
Metamaterials With Tunable Stop Bands

Metamaterials are materials with manmade microstructures. Recently, researchers have looked at a class of metamaterials whose microstructures contain internal degrees of freedom that are different from those of the macro-medium. These metamaterials exhibit unusual dynamic behavior and if modeled as homogeneous solids then their effective mass densities would become negative in certain frequency range. Specifically, a new stop band in the vicinity of the local resonance frequency of the internal mass in the microstructure would result. In this paper, a one dimensional metamaterial is employed to investigate the meaning of the negative mass density in the material and the energy flow in and out of the microstructure. In addition, numerical solutions are used to illustrate the phenomenon.Copyright © 2008 by ASME
Seasonal Emergence and Population Development of the Pink Bollworm in Southern California

Field emergence of moths of Pectinophora gossypiella (Saunders) in the Imperial Valley of California began in 1969 and 1970 during the 1st week of March. Peak emergence occurred during mid-May 1969 and mid-April 1970. Emergence declined rapidly from these peaks but continued at low levels into midsummer when trapping was terminated. Metal-screened emergence cages collected almost twice as many moths as plastic-screened cages. Pheromone trap collections of moths in 1969 in untreated and treated cotton fields showed 5 flight peaks between June 1 and November 1.
Chromosomal Abnormalties with Epilepsy

The correlation between specific chromosome abnormalties and various epilepsies was investigated by a study of 76 patients’ records obtained by questionnaires distributed to members of Kyoto Multi-institutional Study Group of Pediatric Neurology.
Mechanism of Pyridine-Catalyzed SiO2 Atomic Layer Deposition Studied by Fourier Transform Infrared Spectroscopy

Fourier transform infrared (FTIR) investigations were performed to study the mechanism of catalytic SiO2 atomic layer deposition (ALD) using pyridine as the catalyst. Pyridine adsorption on hydroxy...
Prestressed concrete design in the reconstruction project of wutan company's second dining-room in Daqing

The reconstruction project of Daqing wutan company's second dining-room adopts prestressed concrete frames which span is 19.8m. This paper introduces the design method of prestressed concrete frame structure, and gives a method to use bearing to deal with the big moment in topside pillar of large-span frame. These may be will reference to design homogeneous building structures.
Fruit quality characteristics influence prices received for processing apples

This study quantifies the discounts and premiums associated with various quality factors for processing apples (Malus domestica Borkh.). Discounts and premiums were estimted using a hedonic price model and quality data from a total of 137 samples representing three processing apple cultivars (45 'York Imperial', 43 'Rome Beauty', and 49 'Golden Delicious'). Price discounts in the sample were statistically significant for fruit size, bruising, bitter pit, decay, misshapen apples, and internal breakdown [...]
Limitations of Current Plasma VonWillebrand Factor (VWF) Activity Tests: A Comprehensive Comparison of Five VWF Activity Assays.

Abstract Accurate measurement of plasma von Willebrand factor (VWF) activity is essential for the laboratory diagnosis and treatment monitoring of von Willebrand disease (VWD). Currently available VWF activity assays include VWF ristocetin cofactor activity by manual light transmission platelet aggregometry (VWF:RCo–Agg) or flow cytometry (VWF:RCo–FL), collagen I and III binding activity (VWF:Co–I and –III) (Technozym), and platelet activity by latex agglutination (VWF:Lx) (Instrumental Laboratory). In this study we evaluated and compared the accuracy and precision of these 5 assay methods. Plasma samples from 11 normal donors and 41 patients categorized as type 1 (n=20) or type 2 (n=21) VWD based on clinical evaluation, fVIII:C activity, VWF:RCo–Agg, VWF antigen (VWF:Ag) level and plasma VWF multimer analysis by agarose gel electrophoresis were assayed for VWF activity by VWF:RCo–FL, VWF:Co–I, VWF:Co–III and VWF:Lx methods. The VWF:Ag/VWF activity ratio by VWF activity assay method was calculated for each sample. For normal donors and type I VWD patients, VWF:RCo–FL and VWF:Lx correlated well with VWF:RCo–Agg (R2=0.87, and 0.97, respectively), while VWF:Co–I and –III were lower compared to VWF:RCo-Agg. For type 2 VWD patients, different VWF:Ag/VWF activity ratio cutoffs (range 0.3–0.7) were used (Figure). Both VWF:RCo–Agg and –FL were sensitive (95%) and specific (97%) for type 2 VWD while the VWF:Lx was slightly less sensitive (81%) but was very specific (100%). VWF:Co–I and –III were the least sensitive (
Motherhood and the Yugoslav Communist State in the Revolutionary Era, 1943–1953

In 1943, the Croatian branch of the sole gender-specific organisation in the communist-led Yugoslav Partisan movement, the Antifascist Front of Women (AFŽ), launched its wartime journal, Žena u borbi (Woman in the struggle). The cover of the journal’s first issue features a sketch of a strong, angry-looking barefoot woman holding a young child in her left arm and a rifle in her right hand. She emanates determination and forcefulness (Fig. 12.1).
Low Vowel ˝Lengthening˝ in Hungarian

This paper examined the topic of Low Vowel Lengthening in Hungarian, which is a term describing the short-long alternation that low vowels show. After an introduction of the vowel system and phonotactics of the language, two main criteria were identified that an analysis of LVL has to satisfy: (i) being able to explain suffixes that do not trigger LVL, yet interact with the stem and (ii) being a close-fitting model for other phenomena related to linking vowels, as well (the need for the latter rose from a functional motivation). From the two possible groups of analyses (lengthening and shortening approaches), it was lengthening that proved to be a more suitable account for the phenomena. Examples of both were given with explanation and evaluation on the two criteria. Finally, the empty-V approach suggested in this paper was also tested against these criteria.
Emi1 Is Required for Normal Cell Cycle Progression in Zebrafish Myelopoiesis and Likely Functions as a Haploinsufficient Tumor Suppressor on Chromosome 6q in Human Leukmias.

Myelopoiesis is a developmental process through which stem cells give rise to mature monocytes and granulocytes by means of a tightly regulated cellular program. The molecular mechanisms controlling myelopoiesis are incompletely understood, as are the abnormalities in this process that give rise to myeloid cell diseases, such as leukemia, myelodysplasia, and myeloproliferative syndromes. These diseases are commonly associated with somatically acquired large chromosomal deletions, making the identification of the causative tumor suppressor genes difficult. To learn more about the genes required for normal myelopoiesis, which we postulated might be mutated during the molecular pathogenesis of myeloid malignancies, we performed a screen using a panel of insertional mutants provided by Nancy Hopkins (MIT) to identify zebrafish lines with deficiencies in myeloperoxidase (mpo), a gene specifically expressed in granulocytes. As part of this screen, we identified the line hi2648, in which homozygous mutants have a severe reduction in the numbers of mature myeloid cells expressing either mpo or l-plastin, and in which the small numbers of residual myeloid cells are abnormally large. We bred hi2648 mutant fish to a line carrying the pu.1:GFP transgene and found that the homozygous mutant embryos displayed decreased numbers but relatively large GFP-positive cells, which were also observed in cytospins of FACS-purified, GFP-expressing cells, consistent with our in situ analysis. Hi2648 harbors a retroviral insertion that disrupts the gene emi1 between exons one and two, resulting in decreased levels of emi1 RNA assayed by whole- mount in situ analysis. We confirmed that the hematopoietic phenotype in this line is due to disruption of emi1 by showing that we could phenocopy the mutant using emi1-specific morpholinos and also by rescuing the mutant phenotype using forced expression of emi1 RNA. The Emi1 gene product has been shown to inhibit anaphase-promoting complex during interphase of the cell cycle. We analyzed emi1-mutant embryos for cell cycle defects by FACS analysis of propidium-iodide stained cells at 21 hpf, and showed that impaired emi1 expression results in an accumulation of cells in G2 phase, presumably due to premature activation of APC during S- and G2-phase with an inability to accumulate adequate levels cyclin B. We also observed a range of increased of levels of cellular DNA content greater than the normal 4n complement, suggesting that loss of emi1 also promotes abortive endoreduplication. Mutational analysis indicated gene-specific disruption in of emi1 in a human leukemia cell line, suggesting that this gene represents one of the long-sought haploinsufficient tumor suppressors located on the long arm of human chromosome 6 (del 6q), whose loss promotes genomic instability during leukemogenesis and the progression of MDS to AML in man.
THE INTERACTIONS OF BrdU-SUBSTITUTED DNA WITH LAC REPRESSOR AND HISTONES

The interactions of lac repressor and histones to BrdU-substituted DNA and the normal DNA has been studied by nitrocellulose membrane filter methods. Competition with unlabeled operator DNA and poly[d(A-T)] indicates that lac repressor binds about ten fold tighter to BrdU-substituted operator DNA than to the normal operator DNA. Inducer inhibition and heat inactivation studies show that repressor-BrdU operator DNA complex is more stable than the repressor-normal operator complex. The interaction of BrdU-operator DNA to repressor appears to be more sensitive to pH temperature and ionic strength than the normal operator DNA. Histones, H1 and H4 bind more tightly to poly[d(A-BrU)] than to poly[d(A-T)]. The histone interaction with BrdU-DNA is highly susceptible to the presence of urea. This suggests that one reason for the increased affinity of BrdU-DNA to proteins is due to an enhancement of the hydrophobic interaction. The increased affinity of BrdU-DNA to lac repressor and histones may at least partially explain the specific effects of BrdU in gene regulation.
Deviation from expected cognitive ability across psychotic disorders

Patients with schizophrenia show a deficit in cognitive ability compared to estimated premorbid and familial intellectual abilities. However, the degree to which this pattern holds across psychotic disorders and is familial is unclear. The present study examined deviation from expected cognitive level in schizophrenia, schizoaffective disorder, and psychotic bipolar disorder probands and their first-degree relatives. Using a norm-based regression approach, parental education and WRAT-IV Reading scores (both significant predictors of cognitive level in the healthy control group) were used to predict global neuropsychological function as measured by the composite score from the Brief Assessment of Cognition in Schizophrenia (BACS) test in probands and relatives. When compared to healthy control group, psychotic probands showed a significant gap between observed and predicted BACS composite scores and a greater likelihood of robust cognitive decline. This effect was not seen in unaffected relatives. While BACS and WRAT-IV Reading scores were themselves highly familial, the decline in cognitive function from expectation had lower estimates of familiality. Thus, illness-related factors such as epigenetic, treatment, or pathophysiological factors may be important causes of illness related decline in cognitive abilities across psychotic disorders. This is consistent with the markedly greater level of cognitive impairment seen in affected individuals compared to their unaffected family members.
Face poser: interactive modeling of 3D facial expressions using model priors

In this paper, we present an intuitive interface for interactively posing 3D facial expressions. The user can create and edit facial expressions by drawing freeform strokes, or by directly dragging facial points in 2D screen space. Designing such an interface for face modeling and editing is challenging because many unnatural facial expressions might be consistent with the ambiguous user input. The system automatically learns a model prior from a prerecorded facial expression database and uses it to remove the ambiguity. We formulate the problem in a maximum a posteriori (MAP) framework by combining the prior with user-defined constraints. Maximizing the posterior allows us to generate an optimal and natural facial expression that satisfies the user-defined constraints. Our system is interactive; it is also simple and easy to use. A first-time user can learn to use the system and start creating a variety of natural face models within minutes. We evaluate the performance of our approach with cross validation tests, and by comparing with alternative techniques.
TAILORING EPIC, A GROUP-BASED SHARE INTERVENTION, TO MEET THE NEEDS OF SPANISH SPEAKERS

This presentation provides insights on tailoring EPIC’s outreach, assessment, and intervention activities for Spanish Speaking Latinos. EPIC (a group-based intervention protocol derived from SHARE) is designed to reduce stress and enhance well-being of people with early-stage dementia and their care partners. Steps in tailoring included: ongoing community advisory board feedback; conceptual translation of all project material; and incorporation of suggestions from six focus groups with 51 Latino family caregivers, professionals, and direct care staff. Participants regarded the project’s revised care values and preferences as critically important for Latino families (“excellent visual aids”; “concepts are simple to understand and manage”; “very useful”, “these activities would help to have a conversation and come to agreement”). Feedback also helped to expand Latino outreach efforts by choosing less threatening language to describe dementia, speaking at existing community health classes, conducting Concerned about Changes in Your Memory? forums, and using social media across the generations.
Greentech Media, Inc.: Utilizing Digital Platforms

This case is used in Darden's "Digital Marketing" course. How quickly can an organization rewrite the way a B2B industry functions? The cofounders of Greentech Media introduced a business model from the telecommunications space to green technology, led digital content distribution as an industry innovation, and quickly became the most visited solar content website online. In doing so, this B2B online media and research company learned that the nascent nature of the industry required its business model, its marketing, and its sales team to adapt to accommodate a dearth of institutional knowledge. Using e-mail newsletters and social media, the marketing manager says of the company's approach: “technology and marketing are the same thing now.” Excerpt UVA-M-0846 Jan. 23, 2013 GREENTECH MEDIA, INC.: UTILIZING DIGITAL PLATFORMS Many start-ups have unique, entrepreneurial leaders. Scott Clavenna had the experience and success to attract venture capital funding: He had taken a chance in the emerging field of business media, integrating market research with a media company; he had succeeded at fundraising; and he had built a team and positioned an organization for exit. His cofounder, Rick Thompson, an industrial engineer by training with breadth of work experience, was known to “hire for personality and intelligence, not background.” In February 2007, with $ 1 million in venture capital funding, Thompson and Clavenna had formed Greentech Media, Inc., an online media company comprising cutting-edge news, in-depth market research, and focused industry events. Alternative energy executives often described devotion to their causes, but Thompson and Clavenna had been attracted to the business opportunity of the industry rather than a commitment to green principles. Clavenna and Thompson had worked together at Light Reading Inc., a market research, events, and publishing company for the telecommunications industry, which had experienced an explosion of growth between 1996 and 2003. In forming a new company, they wanted to identify an opportunity for the kinds of research-focused products they were familiar with at Light Reading. Global investments in renewable energy were expected to reach $ 653.35 billion by 2015. And by 2011, the worldwide installed capacity of renewable energy was expected to surpass that of nuclear power for the first time. Green technology seemed to be a good bet. The Business Concept . . .
BLOOD FLOW-DEPENDENT FUNCTIONAL RECOVERY IN A RAT MODEL OF FOCAL CEREBRAL ISCHEMIA

The reduction in focal infarct volume after L-arginine has been attributed to an increase in regional cerebral blood flow (rCBF) within ischemic tissue. We tested the hypothesis that L-arginine-induced rCBF increases precede the recovery of spontaneous electrical activity [electrocorticogram (ECoG)] in spontaneously hypertensive rats subjected to middle cerebral artery (MCA) occlusion. ECoG was recorded from the penumbral region of parietal cortex by a glass microelectrode inserted into 1-mm3 cortical tissue from which blood flow was sampled by laser-Doppler flowmetry. rCBF dropped to 21 +/- 8% of the preischemic level, and ECoG was depressed by 64 +/- 13% after distal MCA occlusion. L-Arginine infusion (300 mg/kg i.v.) increased rCBF in 14 out of 18 rats, and ECoG significantly recovered in seven rats in which rCBF exceeded 31% of preischemic flow. Increases in rCBF anticipated the functional improvement in every case. Saline (n = 6) or D-arginine (n = 5) administration was ineffective. These data demonstrate that increasing rCBF can promote functional recovery in the ischemic brain and suggest that early administration of L-arginine or other vasodilators may enhance tissue survival by increasing rCBF.
Taste Responses to Linoleic Acid: A Crowdsourced Population Study

Dietary fats serve multiple essential roles in human health but may also contribute to acute and chronic health complications. Thus, understanding mechanisms that influence fat ingestion are critical. All sensory systems may contribute relevant cues to fat detection, with the most recent evidence supporting a role for the sense of taste. Taste detection thresholds for fat vary markedly between individuals and responses are not normally distributed. Genetics may contribute to these observations. Using crowdsourced data obtained from families visiting the Denver Museum of Nature & Science, our objective was to estimate the heritability of fat taste (oleogustus). A pedigree analysis was conducted with 106 families (643 individuals) who rated the fat taste intensity of graded concentrations of linoleic acid (LA) embedded in taste strips. The findings estimate that 19% (P = 0.043) of the variability of taste response to LA relative to baseline is heritable at the highest concentration tested.
High-dimensional fitting of sparse datasets of CCSD(T) electronic energies and MP2 dipole moments, illustrated for the formic acid dimer and its complex IR spectrum.

We present high-level, coupled-mode calculations of the infrared spectrum of the cyclic formic acid dimer. The calculations make use of full-dimensional, ab initio potential energy and dipole moment surfaces. The potential is a linear least-squares fit to 13 475 CCSD(T)-F12a/haTZ (haTZ means aug-cc-pVTZ basis set for O and C, and cc-pVTZ for H) energies, and the dipole moment surface is a fit to the dipole components, calculated at the MP2/haTZ level of theory. The variables of both fits are all (45) internuclear distances (actually Morse variables). The potential, which is fully permutationally invariant, is the one published recently and the dipole moment surface is newly reported here. Details of the fits, especially the dipole moment, and the database of configurations are given. The infrared spectrum of the dimer is calculated by solving the nuclear Schrodinger equation using a vibrational self-consistent field and virtual-state configuration interaction method, with subsets of the 24 normal modes, up to 15 modes. The calculations indicate strong mode-coupling in the C—H and O—H stretching region of the spectrum. Comparisons are made with experiments and the complexity of the experimental spectrum in the C—H and O—H stretching region is successfully reproduced.
The role of catecholamines in HIV neuropathogenesis

Abstract The success of anti-retroviral therapy has improved the quality of life and lifespan of HIV + individuals, transforming HIV infection into a chronic condition. These improvements have come with a cost, as chronic HIV infection and long-term therapy have resulted in the emergence of a number of new pathologies. This includes a variety of the neuropathological and neurocognitive effects collectively known as HIVassociated neurocognitive disorders (HAND) or NeuroHIV. These effects persist even in the absence of viral replication, suggesting that they are mediated the long-term changes in the CNS induced by HIV infection rather than by active replication. Among these effects are significant changes in catecholaminergic neurotransmission, especially in dopaminergic brain regions. In HIV-infected individuals not treated with ARV show prominent neuropathology is common in dopamine-rich brain regions and altered autonomic nervous system activity. Even infected individuals on therapy, there is significant dopaminergic neuropathology, and elevated stress and norepinephrine levels correlate with a decreased effectiveness of antiretroviral drugs. As catecholamines function as immunomodulatory factors, the resultant dysregulation of catecholaminergic tone could substantially alter the development of HIVassociated neuroinflammation and neuropathology. In this review, we discuss the role of catecholamines in the etiology of HIV neuropathogenesis. Providing a comprehensive examination of what is known about these molecules in the context of HIV-associated disease demonstrates the importance of further studies in this area, and may open the door to new therapeutic strategies that specifically ameliorate the effects of catecholaminergic dysregulation on NeuroHIV.
New Developments in Systems Theory Relevant to Biology

While most of the papers at this auspicious meeting are concerned with biology (a field in which I cannot tell you anything you don’t already know much better), my talk will be concerned with systems theory and mathematics. There has been much excitement (and tangible progress) in systems theory recently. I shall try to describe some important results in conceptual terms which may suggest applications to biology, since I feel that there should be such applications.
Research Ethics Consultation at the Johns Hopkins Bloomberg School of Public Health.

A lthough many hospitals have long offered a clini /Jk cal ethics consultation service to their physicians, JL JLpatients, and allied health professionals, formal ethics consultation in the research setting is a relatively new development.1 This article describes the Research Ethics Consulting Service (RECS) that was launched in March 2005 at the Johns Hopkins Bloomberg School of Public Health (JHSPH). Johns Hopkins University was one of 142 institutions that received funding in fiscal year 2002 to develop programs to "strengthen the over sight of human subject research."2 After obtaining the capacity development grant, the authors?faculty mem bers at the Bergman Institute of Bioethics (BI) with appointments in the school of public health?conducted a needs assessment to determine what types of continu ing education in research ethics would be most useful to school faculty. The universal preference was for a con sulting service that would give faculty the opportunity, in real-time, to discuss challenging ethical issues they faced at various stages of their research, with emphasis on issues particular to their work. The authors determined early in discussions with faculty and key senior adminis trators that the goal of such a consulting service would be to assist investigators (whether faculty, staff, or stu dents) in navigating the ethical challenges that might arise in the design, conduct, or analysis of research proj ects involving human subjects. At the end of the six-month pilot period, the JHSPH Office for Research Subjects (ORS) decided to provide salary support for the authors to manage the RECS as a regular component in the school of public health. The focus of this article is to show how the RECS is organ ized, how it responds to and manages requests for con sultations, and what types of consultations the service has provided since its inception.
Interrelations and Applications of Mathematical Demography to Selected Problems in Fruit Fly Management

I address 2 sets of demographic problems in this paper. The first group concerns the application of life table methods to statistical and arithmetic problems in tephritid ecology and management. Here I introduce the notion of the life table as a statistical tool and the concept of multiple decrement tables. I then establish connections between formal demography and Abbot’s Correction, Key Factor Analysis and Probit Analysis. The second group of problems concerns estimating population growth rate, r, from population age structure or sex ratio if relative survival and relative trappability of 2 age groups or of each sex is known. Formulae are given for determining r using either the nulliparous:parous ratio or the sex ratio of captured adults. Eleven sample problems are interspersed in the text to clarify most of the main techniques or concepts. A general discussion of life tables and stable population theory is included at the end.
Ist Content King? – Zur Bedeutung neuer Content-Formate

Der Beitrag diskutiert den Wert von journalistischem Content im Zeitalter der Medienkonvergenz. Dabei geht er auf veranderte, vom Journalismus zu berucksichtigende Rahmenbedingungen ein. Einerseits haben sich im Internet neue Konkurrenten entwickelt, die Nachrichten vielfaltigen und zumeist kostenlos anbieten. Andererseits zeigen sich bei den Rezipienten veranderte Rezeptionssituationen. Um Inhalte zu produzieren, die den Rezipienten trotz der veranderten Konkurrenzsituation etwas wert sind, sollte der Journalismus Themen qualitativ hochwertig bearbeiten und in innovativen Erzahlformaten vermitteln. Dabei ist es entscheidend, das passende Format auszuwahlen, das die jeweilige Geschichte am besten vermitteln kann. Der Beitrag beschreibt konkrete Formate, die narrative und visuelle Vermittlungsstrategien nutzen, wie das (Crossmedia-) Storytelling und den Datenjournalismus.