cssi/SciSciGPT-SciSciNet huggingface dataset:
Effects of Verbalization on Lineup Face Recognition in an Interpolated Inspection Paradigm

SUMMARY We examined the effects of describing a target face on face memory in a procedure in which subjects either did or did not inspect a single distractor face to determine if it matched the target face before attempting lineup identification of both the target and the distractor. Verbalization did not affect accuracy of identification of the target face; however, it increased accuracy during inspection of the distractor face and improved subsequent lineup identification of the distractor face. The absence of description-related impairment of memory for the target face (i.e. the failure to find verbal overshadowing), and the fact that verbalization has the potential positive effect of reducing false alarms to the distractor, points to the complex relation between verbalization and memory for faces. Copyright # 2004 John Wiley & Sons, Ltd. In the course of a criminal investigation, a single eyewitness may be called upon to verbally describe a perpetrator’s face, inspect one or more individual photos to determine whether they show the face of the perpetrator, and attempt photo lineup identification of the perpetrator’s face. Hereafter we will refer to these activities as description, inspection, and lineup identification. Because a single witness may be given multiple tests of face memory, it is important to ask whether participation in one test affects accuracy on another test. Therefore, various combinations of face memory tests have been investigated, including varying the presence of description prior to either lineup identification (e.g. Dodson, Johnson, & Schooler, 1997; Ryan & Schooler, 1998; Schooler & EngstlerSchooler, 1990) or inspection (Mauldin & Laughery, 1981; McClure & Shaw, 2002; Memon & Bartlett, 2002), and varying the presence of interpolated inspection after description and before lineup identification (Cutler, Penrod, & Martens, 1987; Dysart, Lindsay, Hammond, & Dupuis, Experiment 2, 2001; Lindsay, Nosworthy, Martin, & Martynuck, Experiment 1, 1994). These studies have shown that participation in one test can affect performance on another, as in the verbal overshadowing effect, whereby description relative to no-description impairs lineup identification (Schooler & EngslterSchooler, 1990; Meissner & Brigham, 2001).
SAC1-LIKE DOMAINS OF YEAST SAC1, INP52, AND INP53 AND OF HUMAN SYNAPTOJANIN ENCODE POLYPHOSPHOINOSITIDE PHOSPHATASES

The SAC1 gene product has been implicated in the regulation of actin cytoskeleton, secretion from the Golgi, and microsomal ATP transport; yet its function is unknown. Within SAC1 is an evolutionarily conserved 300-amino acid region, designated a SAC1-like domain, that is also present at the amino termini of the inositol polyphosphate 5-phosphatases, mammalian synaptojanin, and certain yeast INP5 gene products. Here we report that SAC1-like domains have intrinsic enzymatic activity that defines a new class of polyphosphoinositide phosphatase (PPIPase). Purified recombinantSAC1-like domains convert yeast lipids phosphatidylinositol (PI) 3-phosphate, PI 4-phosphate, and PI 3,5-bisphosphate to PI, whereas PI 4,5-bisphosphate is not a substrate. Yeast lacking Sac1p exhibit 10-, 2.5-, and 2-fold increases in the cellular levels of PI 4-phosphate, PI 3,5-bisphosphate, and PI 3-phosphate, respectively. The 5-phosphatase domains of synaptojanin, Inp52p, and Inp53p are also catalytic, thus representing the first examples of an inositol signaling protein with two distinct lipid phosphatase active sites within a single polypeptide chain. Together, our data provide a long sought mechanism as to how defects in Sac1p overcome certain actin mutants and bypass the requirement for yeast phosphatidylinositol/phosphatidylcholine transfer protein, Sec14p. We demonstrate that PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization and suggest signaling roles for phosphoinositides other than PI 4,5-bisphosphate in these processes. Additionally, the tethering of PPIPase and 5-phosphatase activities indicate a novel mechanism by which concerted phosphoinositide hydrolysis participates in membrane trafficking.
Towards continuous availability of Internet services through availability domains

The increasing number of Internet users has caused a dramatic increase in electronic commerce. This growth is outpacing technologies for dependability, causing traditional views of high availability to come under question. In particular, Internet failures are a phenomenon external to the owner of a commerce site that must be dealt with, and therefore, geographically distributed servers are a basic availability requirement for e-commerce sites. Geographic distribution provides an opportunity to view users in different roles based on those distributed components they must access. This paper presents an approach based on partitioning online function into domains, each of which provides service to users in a specific role. Coordination between domains is eliminated as much as possible by exploiting application-specific knowledge. Once partitioned, availability techniques may be applied to each domain independently. We argue such an approach is necessary to deal with the geographic distribution of system components imposed by the nature of the Internet and maps well onto real e-commerce deployments.
Skeletal-Carbonate Neptunian Dikes of the Capitan Reef: Permian, Guadalupe Mountains, Texas, U.S.A.

Sedimentary dikes in the Permian (Guadalupian) Capitan Reef of West Texas and New Mexico are composed of siliceous sand, skeletal carbonate, or cement. Skeletal-carbonate neptunian dikes appear to be a relatively uncommon type; only four are known by the authors, but they are important in providing information about platform growth, sediment sources, and dispersal on the platform, and the biota that were present on the platform. The dikes occur within massive poorly sorted skeletal grainstones typical of the reefal part of the Capitan Formation (the Capitan-massive) that is correlative with upper Guadalupian Yates B strata on the platform. They formed during later Yates B, Yates C, and Tansill deposition on the platform, following closely a major period of progradation of the platform margin. The dikes are approximately vertical, and parallel to and within about 100 m of the platform margin. Fissure formation was a probable consequence of flexing and fracturing of lithified shallow-water Capitan-massive over compacting unconsolidated slope and basinal sediment. At least three stages of opening and filling are recorded in the largest and most complex dike, with each sequential fissure opening forming on the basinward side of the previous cemented filling. In two of the dikes, centimeter-thick deposits of vertically laminated peloidal grainstone, which formed in situ within microbial films on the fissure wall, preceded filling by skeletal sediment. Skeletal fossils within two of the dikes are well preserved and represent organisms that either were living within the fissures or were living on the adjacent sea floor and were washed into the fissures soon after death. Other skeletal grains in these dikes, and all of those in the other two dikes, are abraded, strongly micritized, and encrusted with microbial micrite, indicative of having lain on the sea floor for a considerable time before being deposited in the fissures. Fossils in the dikes are characteristic of the reefal and adjacent outer-shelf facies tracts, but they are a biased record of the biota of that depositional area in that they consist largely of vagile or only weakly attached members of the dweller and baffler guilds living on the reef surface and of organisms living within the fissures; members of the reefal framework communities are largely absent. The absence in the dikes of fossils diagnostic of more distant facies tracts indicates that there was little across-platform movement of carbonate sediment on the platform. Deposition of terrigenous sediment is correlated with a sea-level low-stand, indicating that land-derived sediment moved across the platform otherwise infrequently.
Tectonic structures on the Juan de Fuca Ridge

The northern Juan de Fuca Ridge is an actively spreading part of the East Pacific Rise system that is flooded with young turbidite sediments from the nearby continental margin. A detailed geophysical survey was completed at the intersection of the ridge with the Sovanco Fracture Zone. North-south and east-west seismic reflection profiles, spaced 10 km apart on a grid 110 km on a side, were taken with a medium-frequency (200 Hz) electromagnetic source. Profiles give as much as 1.5 sec of penetration, yet show very detailed structure in the turbidite layering. The ridge-crest area is typified by its two axial valleys and associated normal-fault blocks rotated away from the crest. These fault blocks, made strikingly visible by the once-horizontal turbidites, range in horizontal dimension from less than 1 km to 8 km, and they are rotated as much as 8°. Normal faults are clearly visible in the sediments of the axial valley (Middle Valley) as discontinuities along acoustic reflectors. These faults dip toward the center of the valley at angles from about 45° to nearly vertical (>80°). Of the two axial valleys, only one (West Valley) is currently active. Profiles and bottom photographs show pillow basalt cropping out over most of the West Valley floor, but some rifted sediments exist as well. The second axial valley (Middle Valley) appears to be currently inactive. It is completely sediment filled (sediment thickness as much as 3.0 km), and although clearly visible normal faults extend through the full section seen in the profiles, extensional rates calculated on these faults are only about 0.2 cm/yr. Over the rest of its length, the Juan de Fuca Ridge crest has no significant axial valley. Only on its northern end near its intersection with the Sovanco Fracture Zone does it develop an axial valley. Similar observations have been made on the Explorer Ridge and on the East Pacific Rise, Gulf of California, although the mechanism for this is not yet understood. Other observations of axial valleys in general — namely, the nonisostatic relief of the valleys, their dependence on spreading rate for generation, and the formation and rotation of normal-fault blocks away from the valley floors — all seem best explained by a passive mechanism where complete crust and upper mantle accretion occurs by passive intrusion over a zone wider than the width of the initial formation of a rigid surface layer.
Modular multi-resolution vision processor

We have been developing processing modules, and processor systems which consist of these modules, dedicated to visual recognition. These processor systems and modules are expected to be efficient and reliable for various kinds of computer vision applications. The modules developed are listed below: (1) Direct Image Correlation Module (2) Multiple Model Images Module (3) Real-time Edge Detection Module (4) Multiple Resolution Module This paper focuses on the multiple resolution module which was developed after presenting the last paper in the 1985 IEEE International Conference on Robotics and Automation (1). This module made it possible to decrease the processing time from 2.5 sec to 0.03 sec (less than the image acquisition time) for medium resolution (128×128) images.
Optimization Techniques for the Synchronization of Concurrent Fluidic Operations in Pin-Constrained Digital Microfluidic Biochips

The implementation of bioassays in pin-constrained digital microfluidic biochips may involve pin-actuation conflicts if the concurrently-implemented fluidic operations are not carefully synchronized. We propose a two-phase optimization method to identify and synchronize the fluidic operations that can be executed in parallel. The goal is to implement these fluidic operations without pin-actuation conflict, and minimize the duration of implementing the outcome sequence after synchronization. We also extend the synchronization method with the addition of a small number of control pins, in order to further minimize the completion time while avoiding pin-actuation conflicts. The effectiveness of the proposed synchronization method is demonstrated for a representative 3-plex assay performed on a commercial pin-constrained biochip and for multiplexed in-vitro diagnostics performed on an experimental pin-constrained biochip.
Multi-spectral medical image visualization with self-organizing maps

The effective display of multi-parameter medical image data sets is assuming increasing importance as more distinct imaging modalities are becoming available. For medical purposes, one desirable goal is to fuse such data sets into a single most informative gray-scale image without making rigid classification decisions. A visualization technique based on a non-linear projection onto a 1-D self-organizing map is described and examples are shown. The SOM visualization technique is fast, theoretically attractive, and has properties which complement those of projection-pursuit or other linear techniques. It may be of particular value in calling attention to specific regions in a multi-parameter image where the component images should be examined in detail. >
A three-dimensional numerical model for satellite-magnetoplasma interactions

Numerical simulations of the electrodynamic interactions between a satellite and magnetoplasma have been carried out using a 3-D particle-in-cell code in cylindrical geometry. The satellite is a finite-sized cylindrical body, which can be biased at a potential. The plasma is composed of electrons and hydrogen ions. Included in the model is a magnetic field, which represents the geomagnetic field and which in the model can be oriented as required. Simulation cases have been performed with and without a relative motion between the satellite and plasma. For the situation without motion, the current collected by the satellite is compared with the available analytical prediction from the theory of L. W. Parker and B. L. Murphy (1967). The current collected in the simulations is found to be in agreement with the theoretical value for different system parameters. For simulations with a relative motion, the current collected by the satellite is found to be enhanced over the nondrifting case. >
National Health Insurance and Health-Based Drug Policy: An Examination of Policy Linkages in the USA and Canada

For more than 50 years the United States and Canada maintained illegal-drug policies that followed the same course: a long period of punitive prohibition followed by moderation and an emphasis on drug abuse as a public health problem. Then in the 1980s, the USA reverted to a punitive model while Canada increased its commitment to a health-based approach. Why this divergence after following the same path for so long? In this paper I argue that one factor was Canada's adoption of national health insurance, which guaranteed universal access to health care, including addiction treatment. As the country's most popular policy it was protected against budget cuts during a period of welfare-state retrenchment in the 1980s. In the USA, on the other hand, public health insurance was limited to the elderly and the poor, and addiction treatment services were isolated and stigmatized. Thus the public health side of drug policy was poorly positioned to resist welfare cutbacks and ascendant criminal-justice interests. The experiences of the USA and Canada have implications for policy reformers and for the study of how institutional interests cross policy domains.
On the instability of an electrostatically sprayed liquid jet

Electrostatic spraying of insulators using field emission or ionization is characterized by the formation of a thin jet. Experimentally, this jet appears to be stable over most of its length. The stability of such a jet is examined theoretically. Since the jet is insulating, the charge injected becomes surface charge. This charge can be redistributed through electric mobility and charge convection. In addition, there is an electric field with a component parallel to the jet. This charge and field result in both a normal and a shearing electrical force. Calculations show that a charge with no tangential field stabilizes the long wavelengths while it makes the short wavelengths more unstable. On the other hand, a tangential electric field stabilizes the short wavelengths. The effect of both charge and the tangential field is much larger than the sum of the two effects separately. Fields and charge densities that are easily achievable in all experiment can be used to produce a stable jet. Calculations of the growth rate of instabilities for different values of the electrical parameters are presented. >
Long form of latent TGF-β binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

Latent TGF-beta binding protein 1 (LTBP1) is a member of the LTBP/fibrillin family of extracellular proteins. Due to the usage of different promoters, LTBP1 exists in two major forms, long (L) and short (S), each expressed in a temporally and spatially unique fashion. Both LTBP1 molecules covalently interact with latent TGF-beta and regulate its function, presumably via interaction with the extracellular matrix (ECM). To explore the in vivo role of Ltbp1 in mouse development, at the time when only the L isoform is expressed, we mutated the Ltbp1L locus by gene targeting. Ltbp1L-null animals die shortly after birth from defects in heart development, consisting of the improper septation of the cardiac outflow tract (OFT) and remodeling of the associated vessels. These cardiac anomalies present as persistent truncus arteriosus (PTA) and interrupted aortic arch (IAA), which are associated with the faulty function of cardiac neural crest cells (CNCCs). The lack of Ltbp1L in the ECM of the septating OFT and associated vessels results in altered gene expression and function of CNCCs and decreased Tgf-beta activity in the OFT. This phenotype reveals a crucial role for Ltbp1L and matrix as extracellular regulators of Tgf-beta activity in heart organogenesis.
Automated recognition of malignancy mentions in biomedical literature.

Background: The rapid proliferation of biomedical text makes it increasingly difficult for researchers to identify, synthesize, and utilize developed knowledge in their fields of interest. Automated information extraction procedures can assist in the acquisition and management of this knowledge. Previous efforts in biomedical text mining have focused primarily upon named entity recognition of well-defined molecular objects such as genes, but less work has been performed to identify disease-related objects and concepts. Furthermore, promise has been tempered by an inability to efficiently scale approaches in ways that minimize manual efforts and still perform with high accuracy. Here, we have applied a machine-learning approach previously successful for identifying molecular entities to a disease concept to determine if the underlying probabilistic model effectively generalizes to unrelated concepts with minimal manual intervention for model retraining. Results: We developed a named entity recognizer (MTag), an entity tagger for recognizing clinical descriptions of malignancy presented in text. The application uses the machine-learning technique Conditional Random Fields with additional domain-specific features. MTag was tested with 1,010 training and 432 evaluation documents pertaining to cancer genomics. Overall, our experiments resulted in 0.85 precision, 0.83 recall, and 0.84 F-measure on the evaluation set. Compared with a baseline system using string matching of text with a neoplasm term list, MTag performed with a much higher recall rate (92.1% vs. 42.1% recall) and demonstrated the ability to learn new patterns. Application of MTag to all MEDLINE abstracts yielded the identification of 580,002 unique and 9,153,340 overall mentions of malignancy. Significantly, addition of an extensive lexicon of malignancy mentions as a feature set for extraction had minimal impact in performance. Conclusion: Together, these results suggest that the identification of disparate biomedical entity classes in free text may be achievable with high accuracy and only moderate additional effort for each new application domain.
Search control techniques for planning

Significant advances have been made in heuristic search for classical planning in the last six years. Most of these planners use A* style search. We report on two sound and complete domain-independent classical planners AWA* (adjusted weighted A*) and MAWA* (modified AWA*) in this paper. AWA* is the first planner to use node-dependent weighting in A*. MAWA* uses a two-phase heuristic evaluation. MAWA* applies node-dependent weighting to a subset of the nodes in the fringe, after the two-phase evaluation. We report on an empirical comparison of AWA*, MAWA* with classical planners AltAlt, FF and STAN 4. Both AWA* and MAWA* outperform AltAlt and STAN 4. Both AWA* and MAWA* solve many problems that FF does not. The ideas in AWA* and MAWA* are general enough to be applicable in solving other planning problems like temporal planning and planning with resources and numerical variables.
Adaptively Routing P2P Queries Using Association Analysis

Unstructured peer-to-peer networks have become a very popular method for content distribution in the past few years. By not enforcing strict rules on the network?s topology or content location, such networks can be created quickly and easily. Unfortunately, because of the unstructured nature of these networks, in order to find content, query messages are flooded to nodes in the network, which results in a large amount of traffic. This work borrows the technique of association analysis from the data mining community and extends it to intelligently forward queries through the network. Because only a small subset of a node?s neighbors are forwarded queries, the number of times those queries are propagated is also reduced, which results in considerably less network traffic. These savings enable the networks to scale to much larger sizes, which allows for more content to be shared and more redundancy to be added to the system, as well as allowing more users to take advantage of such networks.
Incidental finding of an univentricular heart on echocardiogram in an adult patient

A 23-year-old asymptomatic female was sent for an echocardiogram because of a loud murmur heard on auscultation. She never had any cardiac surgeries and reported good exercise tolerance. Echocardiogram revealed a double inlet left ventricle (DILV) with two separate atrio-ventricular (AV) valves opening into a single large morphological left ventricle ( Panels A and B ; …
The bibliosphere of ancient science (outside of Alexandria) : a preliminary survey.

Der Artikel stellt die Methodik zur Erforschung einer „Bibliosphare“ vor, also der Gesamtheit der literarischen Dokumente einer bestimmten Kultur. In diesem Fall geht es um die Bibliosphare der Antike, und hierbei insbesondere um deren wissenschaftlich-philosophischen Bereich. Es wird die Auffassung vertreten, dass wir die Inhalte von Werken durch ihre Position in der Bibliosphare begreifen konnen. Der Gegensatz zwischen Mathematik und Literatur wird detailliert dargestellt und der Ubergangscharakter der Medizin hervorgehoben.
Emergency! Thoracic aortic dissection.

Back pain during labor is no surprise, which is why this very serious complication almost fooled this team.
Analysis and Interpretation of Ecological Field Data Using BACI Designs: Discussion

McDonald, Erickson, and McDonald (2000) and Murtaugh (2000) have presented two interesting views of analysis and interpretation of data from before-after control-impact (BACI) studies. In my opinion, the general message they convey to the reader is that analysis of data from a BACI design, in combination with professional expertise, can add useful evidence as long as one is prudent about the resulting interpretations. Whether scientists who analyze BACI data will indeed use caution in interpretation, particularly in making statements regarding cause and effect, remains to be seen. McDonald et al.'s (2000) study is application specific, taking the reader through an analysis of bird count data from the Exxon Valdez oil spill (EVOS). The authors prudently phrase their interpretation in terms of a weight of evidence argument rather than the much more difficult one of causation. I see the primary usefulness of this paper as that of encouraging scientists to use more complex models to realistically describe count data through time. (Using these models in data analysis has been considerably enhanced by the increasing availability of various types of computer software.) Particularly with biological data, a conventional first step is to try an additive model on untransformed data or an additive model on log-transformed data with the hope that the log transform restores the assumptions of variance homogeneity and normally distributed error terms. The presence of data recorded on the same units through time necessitates that the Huynh-Feldt condition (also known as sphericity) holds in order to use a conventional repeated measures approach. In case this sphericity condition does not hold, there are references to make conservative adjustments to the usual F-tests. (I do wonder just how many people would take the trouble to test these assumptions and do the proper corrections if such corrections were not already built into the
FILLING PATTERN OF THE FORT SHERIDAN GROIN SYSTEM

An analysis of the action of a groin system through the 14 months following construction is reported herein. Six surveys were made during this period which included onshore elevations to the bluff line and offshore soundings to approximately the seven foot depth contour. Wind records during the period of record were studied and hindcasts of wave conditions made. Analysis of the basic data reveals that the cumulative volume of impoundment at the system may be expressed approximately by K(Icos B)^0.97.
APPLICATION OF DUST SUPPRESSION BY SPRAYING TECHNOLOGY TREAT COAL DUST

principle of coal dust appear、technical theory of dust suppression by spraying type of Spraying appliance and structure,engineering application is introduced.The system is easily operation,a simpler process,lower the project cost and good applicable prospect.
Abstract 3588: The spindle assembly checkpoint gene Bub1b is essential for the survival of some breast cancers

As normal breast epithelium evolves towards malignancy, cells accumulate genomic changes that give them a replicative advantage while at the same time increasing their genomic instability. Increased genomic instability results in accumulation of genomic aberrations that compromise the genomic integrity and, therefore, threaten cell viability, thus putting cancer cells under mitotic stress. As a consequence, cancer cells evolutionarily must adapt themselves to compete with the possible detrimental effects of genomic instability. Finding a balance between the instability that gives them a replicative advantage and the instability that could lead them to mitotic catastrophe is crucial. The mitotic stress caused by genomic instability may require overexpression of certain spindle assembly checkpoint (SAC) genes, which can prevent mitotic catastrophe that would occur if cancer cells undergo mitosis prematurely. Although the full mechanism of action of SAC is yet to be elucidated, Bub1b through its protein BubR1 is an important part of this checkpoint, and inhibits the onset of anaphase until all chromosomes are aligned correctly at the metaphase plate. Our analysis of clinical datasets shows a significant increase in the expression of Bub1b in breast cancer as compared to normal epithelia. Furthermore, Bub1b overexpression correlates with decreased overall survival in patient samples. Our analyses also show a pattern of increasing Bub1b overexpression in more aggressive variants of breast cancer such as triple negative tumors and high-grade tumors, which also tend to be more resistant to current therapies. Expression analyses of breast cancer cell lines reveal that Bub1b overexpression is positively correlated with more aggressive behavior. We postulated that the requirement for Bub1b expression might be a vulnerability of rapidly proliferating cancers; therefore, its inhibition will result in cell death through mitotic catastrophe. Using RNA interference with siRNAs, we reduced Bub1b levels in a variety of breast cancer cells. Our results showed significant decrease in cell viability and clonogenicity in soft agar upon Bub1b knockdown, especially in triple negative breast cancer cell lines. However, the viability of normal breast epithelium cells, MCF12A, was not affected. Our data indicate that Bub1b is a critical player in breast cancer viability, and further investigation of the role of Bub1b in promoting successful proliferation of breast cancer cells with genomic instability could provide a new therapeutic strategy particularly in concert with standard genotoxic treatments such as alkylators, spindle poisons and radiation therapy. Citation Format: Dilara Koyuncu, Erik T. Goka, Philip C. Miller, Marc E. Lippman. The spindle assembly checkpoint gene Bub1b is essential for the survival of some breast cancers. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3588.
Chronic Urinary Retention in Multiple Sclerosis Patients: Physiology, Systematic Review of Urodynamic Data, and Recommendations for Care

Many multiple sclerosis (MS) patients are affected by urinary retention. Common causes include neurogenic underactive bladder and/or bladder outlet obstruction from detrusor sphincter dyssynergia. Systemic review of contemporary MS urodynamic studies demonstrates that 53% of MS patients have detrusor overactivity, 43% have detrusor sphincter dyssynergia, and 12% have atonic bladder (12 studies, 1524 patients). There is no standard definition of MS-related urinary retention, but greater than 300 mL is a proposed threshold value for the condition based on literature review. Treatment should be based on stratifying patients by risk from morbidity from retention and by symptoms caused by retention.
Abstract 12008: Comprehensive Bivariate Meta-Analysis of Hypertension Trials With Heart Failure as an Outcome

Introduction: In meta-analyses, odds ratios (OR) are considered more meaningful to summarize data of multiple trials while absolute risk reduction (ARR) is more relevant to specific clinical questions. We developed a novel bivariate random effects meta-analysis method for simultaneous evaluation of ORs and ARRs. Methods: Using this method, we analyzed the efficacy of different classes of antihypertensive therapy in preventing heart failure (HF) in 54 randomized clinical trials not requiring diabetes as an inclusion criterion (331,728 patients, 12,969 events), including SPRINT and HOPE-3. Results: The expected relationship between OR and ARR for a given baseline risk was observed. Diuretics were superior to all other medications, both with respect to ARR and OR (ARR 14.6 per thousand, 95% CI 7.3-22.0; OR 0.52, CI 0.38-0.70). Intensive therapy (ARR 5.1, CI -1.9-12.1; OR 0.72, CI 0.46-1.11) was the second best, followed by ACEIs (ARR 4.9, CI 0.1-9.6; OR 0.81, CI 0.69-0.95), ARBs (ARR 4.4, CI -0.3-8.5; OR 0.90, CI 0.81-0.99), and DHPs (ARR 1.0, CI -3.4-5.4; OR 0.89, CI 0.86-1.16). Verapamil was associated with a trend toward increased absolute risk (ARR 2.3, CI -0.1-4.8; OR 1.17, CI 0.99-1.37). Multiple metaregression identified the magnitude of the difference between the blood pressure lowering from baseline in the active and control groups as the only significant association (p Conclusions: This new bivariate meta-analysis method combining ARR and OR is useful in clinical decision making, using ARR for specific clinical questions, OR to summarize studies. Based on information from all available studies, diuretics are the superior medication for the prevention of HF in hypertensive patients from both points of view.
9 Egocentric Referents in Human Limb Orientation

Testing the hypothesis that spatial localization is made on the basis of an abstract spatial code, rather than on stored proprioceptive information, orientation of the unseen limb was contrasted under same and switched limb movement conditions. In Experiments 1 and 2, movements were executed in the midline vertically upward and horizontally away, respectively. The results of both experiments revealed that same limb accuracy was superior only at farther target positions, and it was hypothesized that orientation of the limb could be mediated by a spatial location code if movements remained within the confines of an egocentric reference system. To test this tentative assertion more directly, Experiment 3 examined same and switched limb performance in two-dimensional space. At locations defined a priori as inside egocentric space, absolute movement accuracy and amplitude error failed to differentiate between same and switched limb localization. At locations defined a priori as outside egocentric space the same limb condition prevailed. Meanwhile, irrespective of spatial position directional error revealed that same limb orientation was superior to switched limb orientation. The amplitude error findings were interpreted to mean that body referent points inside egocentric space allow for the parameterization of the necessary length-tension relationships in the agonist and antagonist muscles of either limb. The direction findings were explained in light of previous data demonstrating systematic perceptual errors in estimating the objective referents.
Daoism and Religious Community Traditions: Their Influence on Chinese Managerial Theory

This paper examines the significant impact of Daoism and the Community Traditional beliefs in shaping Chinese managerial theory. The paper explores the work of Laozi and Zhuangzi, who shaped the more formal religious tradition in China, as well as the more ancient and varied community religious traditions of the Chinese. It is proposed that these two forces have shaped the underlying philosophical orientation of modern managerial theory and practice in China. This influence spreads across the managerial spectrum, from proper human resource management, to strategic decision-making.
Eating and Sleeping

Stressful eating and sleeping patterns are not limited to autistic children. From birth to age 2½ years, all children progress through developmental stages that are clearly explained in child-rearing manuals (Brazelton, 1974; Spock & Rothenberg, 1985) and understood and expected by their parents. Unfortunately, children do not read these manuals and can find too many ways to do it in their own way. This can often be seen in how they gradually learn to feed themselves, try new foods, not eat inedibles, and imitate and accept some rules for table manners. Similarly, it is not unusual for them to dislike leaving their parents to go to sleep alone, to wake in the night and wander around, and to wake up earlier than others would like.
Hemangioendotheliomaitosis of the Liver: A 12-year follow-up

Hemangioendothelioma of the liver is a rare tumor. A case is reported of a middle-aged woman who presented with hepatomegaly and ascites, and who has been followed for over 12 years. The clinical features, pathological, radiographic, portal hemodynamic, and metabolic changes are presented.
Dispersal of Hydrothermal Vent Larvae at East Pacific Rise 9–10°N Segment

Author Posting. © American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research-Oceans, 123(11), (2018): 7877-7895. doi: 10.1029/2018JC014290.
Preferential survival of mice and cells expressing human herpesvirus-8 K1

1930 HHV-8 is associated with the development of primary effusion lymphoma (PEL) and Kaposi’s sarcoma. Expression of the HHV-8 K1 gene driven by a ubiquitous promoter activates nuclear factor-κB and induces lymph node hyperplasia and lymphomas in transgenic mice. K1 inhibits Fas-mediated apoptosis in several lymphoma cell lines. We report here that, compared with nontransgenic littermates, K1 transgenic mice developed enlarged spleens and lymph nodes and had increased rates of tumor development by the age of 15 months. Histological examination of the enlarged spleens demonstrated enlarged germinal centers or destruction of normal spleen structures and areas with clonal expansion of lymphocytes. Because K1 blocks Fas-mediated apoptosis in human cells, we treated splenocytes from K1 transgenic mice and their nontransgenic littermates with agonist anti-Fas antibody (Jo2) for 24 hours. Next, we examined cell death by DAPI staining followed by microscopic morphological change. K1-positive splenocytes showed significantly lower percentages of cell death compared with K1-negative splenocytes (23 ± 0.6% vs. 50 ± 0.5%, P in vivo transfection approach to introduce Flag- or cMyc-tagged K1 into mice liver. Different strains of HHV-8 are identified by different K1 amino acid sequences. We transfected C57B6 mice with plasmids containing K1 from different strains of HHV-8. The expression of K1 in mouse liver was confirmed by Western blot and immunohistochemistry. Sixteen hours after transfection, mice were challenged with a lethal dose of anti-Fas antibody. Four hours after challenged with anti-Fas antibody, mice were sacrificed and liver tissues were formalin fixed and paraffin embedded. The immunohistochemical staining showed lower percentages of cleaved caspase 3-positive cells in K1-transfected liver tissue compared with vector transfected liver tissue (58 ± 15% vs. 87 ± 9%, P lower mouse death rates after challenge with anti-Fas antibody (P We now hypothesize that K1 contributes to cell survival, lymphoproliferation, and lymphoma and may have a role in HHV-8 related human cancers.
LATE GADOLINIUM ENHANCEMENT IN PATIENTS WITH MYOCARDITIS FROM IMMUNE CHECKPOINT INHIBITORS

Myocarditis is a rare but potentially fatal complication of immune checkpoint inhibitors (ICI). Among broad populations, late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) is used for diagnosis and risk prediction in patients with myocarditis. There are no data on the use
Using Disciplinary Approaches for Reading Literary Texts in Developmental Literacy Courses

This forum article discusses using disciplinary literacy approaches for reading literary text targeting interpretation as a goal. Disciplinary literacy approaches make the assumption that literacy ...
The relationship of motivational climates, mindsets, and goal orientations to grit in male adolescent soccer players

Across a variety of domains, such as in academics and in the military, grit is a significant predictor of performance, even after controlling for dimensions of innate ability. However, little is kn...
Anisotropy extraction using a deviated well in the Mahanadi Basin, East Coast of India

Shale is the primary rock type in the shallow marine section of the Mahanadi Basin, East Coast of India. Shale, being intrinsically anisotropic, always affects the seismic data. Anisotropy derived from seismic and VSP has lower resolution and mostly based on P wave. The workflow discussed here uses Gardner equation to derive vertical velocity and uses a nonlinear fitting to extract the Thomsen’s parameters using both the P wave and S wave data. These parameters are used to correct the sonic log of a deviated well as well as anisotropic AVO response of the reservoir. The presence of negative delta was observed, which is believed to be affected by the presence of chloride and illite in the rock matrix. This correction can be used to update the velocity model for time–depth conversion and pore pressure modelling.
Leukemic lineage switch in a t(8;22)(p11.2;q11.2)/BCR-FGFR1-rearranged myeloid/lymphoid neoplasm with RUNX1 mutation - diagnostic pitfalls and clinical management including FGFR1 inhibitor pemigatinib.

Hematologic malignancies with Fibroblast Growth Factor Receptor-1 gene (FGFR) gene rearrangement are a rare group of myeloid/lymphoid neoplasms with eosinophilia and a variety of translocations at ...
Biochar, Manure, and Sawdust Alter Long-Term Water Retention Dynamics in Degraded Soil

Biochars are porous but more recalcitrant that non-pyrolyzed organic materials, hence when biochar is added to soil it may cause more persistent alterations to soil water dynamics as compare to other materials. In this 6-yr, outdoor, large-pot study, we amended an irrigated calcareous silt loam with a single, one-time, 1 or 2% dry wt. (22.4, 44.8 Mg ha-1) application of either hardwood biochar, manure, sawdust, or acidified sawdust, a combined 1% biochar+2% manure treatment, and an untreated control. Each year the soils were hand-tilled and planted to a local crop. Soil water retention and plant available water (PAW, g H2O per g dry soil, being that retained between potentials of -10 to -1500kPa) were measured on spring soil samples. Across all years, the combined 1% biochar+2% manure produced the greatest PAW (0.262), with PAW in all treatments following the order of: 1% biochar+2% manure > all 2% rates > all 1% rates > control (0.222). In most years, the 2% treatments increased soil PAW relative to the control, i.e. their PAW ratios exceeded unity. The PAW ratios for 2% rates varied with amendment and year (P<0.0001). PAW ratios for: i) 2% manure peaked in yr 1 and declined to a minimum in yr 3; ii) 2% biochar, 2% sawdust, and 2% acid sawdust were least in yr 1 and peaked between yr 3 and 5; and iii) 1% biochar+2% manure was consistently near a maximum during the study period. Biochar effects on PAW were no more persistent than that of non-pyrolyzed amendments during the 6-yr study. Several factors influenced soil PAW development in addition to the quantity of the added highly porous amendment. Results suggest that water repellent properties and particle size distribution of the added organic material substantially influenced water retention dynamics in amended soils.
Hepatic and hematological toxicity associated with selective internal radiation therapy (SIRT): A meta-analysis of randomized clinical trials.

546Background: For advanced hepatocellular cancers (HCCs) and colorectal cancers (CRCs) with liver metastasis, the impact of selective internal radiation therapy(SIRT) with yttrium-90 on survival o...
Client and therapist agreement in moment-to-moment helpfulness ratings in psychotherapy: A microprocess approach.

METHOD Clients (n = 16; Mage = 32.88 years; 81% female) and their therapists (n = 10; 80% female) from a training clinic provided moment-to-moment ratings while reviewing a video recording of a recent session. West and Kenny's Truth-and-Bias (T&B) model was used to examine agreement in ratings. Multilevel modeling was used to evaluate the agreement-alliance association while controlling for sessions completed. RESULTS Consistent with the T&B model, client-therapist ratings were temporally congruent and were not discrepant overall. Greater congruence and smaller discrepancies were linked with stronger alliances. CONCLUSIONS The within-session and between-dyad variability in helpfulness ratings highlight the utility of moment-to-moment rating methods. Findings suggest that therapists should attune to client perceptions on a within-session level and attunement may be a target for enhancing the alliance.
Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism.

Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic reprogramming plays a critical role in the activation of these bone cells and skeletal metabolism, which fulfills the energy demand for bone remodeling. Among various metabolic pathways, the importance of lipid metabolism in bone cells has long been appreciated. More recent studies also establish the link between bone loss and lipid-altering conditions—such as atherosclerotic vascular disease, hyperlipidemia, and obesity—and uncover the detrimental effect of fat accumulation on skeletal homeostasis and increased risk of fracture. Targeting lipid metabolism with statin, a lipid-lowering drug, has been shown to improve bone density and quality in metabolic bone diseases. However, the molecular mechanisms of lipid-mediated regulation in osteoclasts are not completely understood. Thus, a better understanding of lipid metabolism in osteoclasts can be used to harness bone cell activity to treat pathological bone disorders. This review summarizes the recent developments of the contribution of lipid metabolism to the function and phenotype of osteoclasts.
Accounting Rules and Post-Acquisition Profitability for Business Combinations

Prior studies report a decline or no change in acquirers' profitability after a merger or business acquisition. Those studies, however, do not consider the downward impact on profitability that stems from use of the "purchase accounting" (and in later periods, "acquisition") method for business combinations. Drawing on financial statement data from both targets and acquirers, we estimate the effects of the application of purchase/acquisition method accounting rules on post-acquisition profitability. We find that recognition rules for acquired inventories, deferred revenues, in-process research and development (IPR&D), and depreciation and amortization expense resulting from writing acquired assets up to fair value vis-a-vis purchase/acquisition accounting methods are all important sources of downward pressure in post-acquisition profitability. We find that investors and analysts appear to recognize the effects of IPR&D in assessing post-acquisition profitability of the combined entity. The findings also suggest that investors and analysts do not appear to fully incorporate the accounting effects related to inventories, deferred revenues, and depreciation and amortization expense for post-acquisition profitability.
Social Science Mechanics: A Graduate Training Module that “Looks under the Hood” at Innovative Research Designs

Scholars in the fields of instructional development and pedagogy note that learning outcomes can be improved when teachers use “narratives” to communicate how complex processes work or how problems are addressed. In this article, the authors describe a narrative-centered approach to graduate-level instruction in research methodology. This approach is intended to supplement, not replace, conventional graduate seminars in quantitative or qualitative methods. In a series of lectures, scholars reflected on how their published articles originally were framed, the trade-offs that were necessary to advance the investigation, the methodological challenges and non-findings that had to be addressed—but may not have been printed—and the evolution of a piece as it progressed through the peer-review stages. This approach to exposing graduate students to the entirety of the research process is termed Social Science Mechanics: A Look under the Hood at Innovative Research Designs. Surveys used to evaluate the series confirmed that graduate students who attended the presentations found them to be highly engaging and beneficial. Many faculty members also attended and found the lectures to be equally instructive.