cssi/SciSciGPT-SciSciNet huggingface dataset:
Vers une écopoésie de l’espace dans ‘Le Nénuphar blanc’ de Stéphane Mallarmé

Stephane Mallarme’s study of rhythm extends beyond his theoretical writings, and can be traced in his prose poem ‘Le Nenuphar blanc’. The imagery of water, vegetation, and the water-lily expands the notion of place in the poem, not merely to highlight the hidden space of a woman in nature, but to extend the consideration of rhythm through a new view of nature itself. Rhythm and movement in visible natural space are amplified through the invisible, inaccessible elements below the surface of the water. Among the underwater stems of bushes and water lilies, Mallarme turns to the floating, submerged, and hidden webs of the natural world. Rather than merely redirecting our gaze towards the artificial and the manmade, the representation of nature in ‘Le Nenuphar blanc’ provides an extended, concrete model for conceptualizing a theoretical space in which an exploration of rhythm — an abstract Mallarmean category — can occur.
Attitude Measurement under Conditions of Multiple Stimuli

Behavioral scientists frequently develop techniques which may have possible applications in marketing. This article describes an exploratory study which seeks to utilize a multiple variable technique for attitude measurement. This technique was developed to examine cognitive conflict in learning situations.
Multi-generational impacts of the psyllid Arytinnis hakani (Hemiptera: Psyllidae) on growth and survival of the invasive weed Genista monspessulana

Abstract Pre-release efficacy assessments of biological control agents can identify species with the most potential to impact the target weed. Experiments typically occur within a single generation of the agent, however, and strong impacts on target weeds may take longer to emerge. This study examined the effects of the prospective agent Arytinnis hakani (Hemiptera: Psyllidae) on the invasive weed French broom, Genista monspessulana , over three generations of the psyllid (∼150 days) under quarantine conditions. All of the psyllid-free control plants survived to the end of the experiment, whereas 23 out of 28 (82.1%) of the plants infested with psyllids died. Only three plants with psyllids died during the first psyllid generation; plant mortality rate peaked at the transition between the second and third psyllid generations. Plant growth was also reduced on plants with psyllids. Impacts on proportional increases in plant height and total stem length were evident by the end of the first psyllid generation, but effects on proportional change in leaf number were not apparent until the end of the third psyllid generation. By the end of the experiment, average proportional increases in height, total stem length and leaf number were 65.7%, 60.7% and 53.2% lower, respectively, on surviving psyllid-infested plants than controls. Final above-ground biomass of surviving psyllid-infested plants was 66.4% lower on average compared to the psyllid-free control plants. The results of this study highlight the need for pre-release efficacy assessments that allow effects on target weeds to develop over time.
Pituitary disorders during pregnancy

A number of morphologic and physiologic changes accompany pregnancy such as an increase in lactotrophs and prolactin production, and a decrease in gonadotropins and GH. The hormonal milieu can affect patients with prolactinomas, especially macroadenomas, to cause an increase in size in a minority of patients. Complications are treated with bromocryptine. Enlargement of GH-secreting tumors with acromegaly may respond to bromocryptine and possibly to octreotide. Pituitary tumors causing Cushing's syndrome may need removal if major complications develop. Hypopituitarism during pregnancy may be the result of lymphocytic hypophysitis or antepartum pituitary necrosis, and in the postpartum period may be because of postpartum hemorrhage and pituitary necrosis. These abnormalities need prompt recognition and hormonal replacement therapy with neurosurgical decompression to avoid serious morbidity and mortality. Posterior pituitary problems in pregnancy usually manifest by diabetes insipidus, with a pregnancy-specific variety resulting from excessive degradation of AVP by placental vasopressinase. The condition is treated with an analogue dDAVP, which is resistant to vasopressinase.
Lichen planus following procainamide-induced lupus erythematosus

A case of procainamide-induced lupus erythematosus with prominent cutaneous features is presented. The patient subsequently showed typical lesions of lichen planus, which has been associated with spontaneously occurring lupus erythematosus, but not previously reported with drug-induced lupus or as a result of procainamide therapy. A review of the immunologic alterations induced by procainamide raises questions about possible mechanisms causing the lupus and lichen planus.
Comparative Effects of Computer-Based Concept Maps, Refutational Texts, and Expository Texts on Science Learning

This study used a between-subjects experimental design to examine the effects of three different computer-based instructional strategies (concept map, refutation text, and expository scientific tex...
Isolation of mycoplasmas from prairie voles (Microtus ochrogaster)

A new species of mycoplasmas was isolated from the lungs and nasopharyngeal washings of prairie voles (Microtus ochrogaster). Clinical signs of disease and microscopic lesions were not observed at the time of this isolation. The organism was cultured in SP4 medium; it grew aerobically, anaerobically, and in 5% CO2 in 5 to 7 days, and fermented glucose. Transmission electron microscopy revealed the organism to lack a cell wall and to have typical mycoplasmal ultrastructural morphology. The complete nucleotide sequence of the 16S rRNA gene from an isolate was determined by amplification with polymerase chain reaction and by sequencing with the dideoxynucleotide chain termination method. The sequence did not match any known sequences in the GenBank of the National Institutes of Health. The 16S rRNA sequence of the organism, Mycoplasma volis (proposed species novum), is unique and most closely resembles that of M. muris and M. iowae. Because this vole colony will be housed in rooms with other rodents, pathogenicity studies of this new species of mycoplasmas in mice and rats are underway.
Family Structure Experiences and Child Socioemotional Development During the First Nine Years of Life: Examining Heterogeneity by Family Structure at Birth.

A vast amount of literature has documented negative associations between family instability and child development, with the largest associations being in the socioemotional (behavioral) domain. Yet, prior work has paid limited attention to differentiating the role of the number, types, and sequencing of family transitions that children experience, as well as to understanding potential heterogeneity in these associations by family structure at birth. We use data from the Fragile Families and Child Wellbeing Study and hierarchical linear models to examine associations of family structure states and transitions with children’s socioemotional development during the first nine years of life. We pay close attention to the type and number of family structure transitions experienced and examine whether associations differ depending on family structure at birth. For children born to cohabiting or noncoresident parents, we find little evidence that subsequent family structure experiences are associated with socioemotional development. For children born to married parents, we find associations between family instability and poorer socioemotional development. However, this largely reflects the influence of parental breakup; we find little evidence that socioemotional trajectories differ for children with various family structure experiences subsequent to their parents’ breakup.
Effects of Collagenase Digestion and Stromal Vascular Fraction Supplementation on Volume Retention of Fat Grafts.

Objective The use of autologous fat as a soft tissue filler has increased over the past decade in both reconstructive and aesthetic surgeries. Enhancement of autologous fat grafts with the addition of the stromal vascular fraction (SVF) has been reported to improve long-term volume retention. Stromal vascular fraction is most commonly isolated using enzymatic digestion, but it is unknown what effect the digestion process has on the adipocytes and SVF cells that comprise the graft. Some clinicians have reported use of enzymatically digested fat grafts to alter the physical properties of the tissue in specialized applications. We have previously reported that increasing collagenase digestion duration adversely affects the viability of adipocytes and SVF cells. Here, we aimed to determine if collagenase digestion of adipocytes before grafting is detrimental to long-term graft retention and if SVF supplementation can abrogate these potential deleterious effects. Methods and results We used a published xenograft model in which human lipoaspirate was implanted into the scalp of immunocompromised mice to study the effects of collagenase digestion on in vivo graft survival after 12 weeks. We used 4 experimental groups: grafts composed of collagenase-digested and nondigested adipocytes (50-minute digestion) and grafts with and without SVF supplementation. We used microcomputed tomography to serially and noninvasively quantify graft volume, in conjunction with hematoxylin-eosin staining of histological cross-sections of implanted and excised grafts to assess overall tissue viability. We found that adipocytes that were collagenase-digested before implantation had significantly lower retention rates at 12 weeks and poorer tissue health, which was assessed by quantifying the number of intact adipocytes, the number of cystic formations, and by scoring the degree of inflammation and fibrosis. Further, we found that SVF supplementation of the digested grafts improved graft survival, but not to the level observed in undigested grafts. Conclusions We conclude that collagenase digestion adversely affects the long-term volume retention of fat grafts, but that graft retention is improved by SVF supplementation. These experimental results can serve as an initial framework to further elucidate the reported efficacy and safety of using collagenase-digested fat grafts and SVF in the clinical setting.
Parathyroid Hormone-Induced Inhibition of Bicarbonate-Dependent Fluid Absorption in the Proximal Renal Tubule of the Rabbit

Although phosphaturia is the most characteristic renal effect of parathyroid hormone, PTH may also affect the renal handling of sodium, bicarbonate, calcium, glucose and amino acids (1). The relationship between these changes and the alterations in phosphate transport is unclear but information on this point may be useful in determining the mechanisms whereby PTH affects such a broad range of renal function.
Additive manufacturing with a flex activated mechanophore for nondestructive assessment of mechanochemical reactivity in complex object geometries

Abstract We used digital light processing additive manufacturing (DLP-AM) to produce mechanochemically responsive test specimens from custom photoresin formulations, wherein designer, flex activated mechanophores enable quantitative assessment of the total mechanophore activation in the specimen. The manufactured object geometries included an octet truss unit cell, a gyroid lattice, and an “8D cubic lattice”. The mechanophore activation in each test specimen was measured as a function of uniaxial compressive strain applied to the structure. Full shape recovery after compression was exhibited in all cases. These proof-of-concept results signify the potential to use flex activated mechanophore for nondestructive, quantitative volumetric assessment of mechanochemistry in test specimens with complex geometries. Additionally, the integration of DLP-AM with flex activated mechanophore build materials enabled the creation of customizable, three-dimensional mechanochemically responsive parts that exhibit small molecule release without undergoing irreversible deformation or fracture.
The Disease Concept of Alcoholism

“The disease concept of alcoholism,” as introduced by Jellinek(23) in 1960 in a book bearing that name, has been an inordinately productive concept both in the range of issues which it raised and also in its medical and social utility. Jellinek derived his concepts from a wealth of clinical experience; the book reflected his attempt to extract certain common denominators characteristic of alcoholism. As a result of his extensive observations, he recognized that not all alcoholics followed the same course. On that basis, he elaborated his clinical typology in which he distinguished alpha and beta alcoholics in whom the symptomatology of physical dependence was not a significant clinical characteristic from gamma and delta alcoholics in whom it was. As physiological concomitants of physical dependence, he postulated the development of craving, loss of control, and inability to abstain, mechanisms which exacerbated the self-reinforcing nature of alcoholism thus making the attainment of abstinence more difficult.
The Impact of Nonsynchronous Trading on Differences in Portfolio Cross-Autocorrelations

It has been widely debated how much nonsynchronous trading drives asymmetric portfolio cross-autocorrelations: lagged returns on a portfolio of larger-capitalization stocks are far more heavily correlated with current returns on a portfolio of smaller-capitalization stocks than the converse. This paper proposes a new method to generate precise estimates of the extent to which nonsynchronous trading underlies these differences. By contrasting cross-autocorrelations using 24-hour portfolio returns based on trade prices before an arbitrary point in the trading day with those using returns based on prices after, our difference-in-differences approach isolates the impact of nonsynchronous trading on differences in portfolio cross-autocorrelations.
Effects of Depressed Mood on Verbal Memory Performance Versus Self-Reports of Cognitive Difficulties

This 2-part study examined the effects of self-reported depressed mood on complaints of cognitive difficulties versus actual performance on tasks assessing verbal memory and intellectual functioning. In the first part of the study, 103 college students provided self-reports of their cognitive difficulties and level of depression by completing the Cognitive Failures Questionnaire, Postconcussion Syndrome Checklist, and Beck Depression Inventory-IA (BDI-IA). Forty eight respondents who obtained BDI-IA scores of less than 9 or greater than 14 participated in the second part of the study. They were again asked to provide self-reports of their level of depression by completing the Beck Depression Inventory-II (BDI-II), and were also tested on their verbal memory and intellectual abilities. Parallel forms reliability of the BDI-IA and the BDI-II was r = .66. Severity of depression was not associated with actual verbal memory or intellectual performance, but was significantly associated with self-reports of cognitive difficulties. The results confirm past findings that individuals who are depressed report more cognitive problems than are actually present. This study also presented descriptive data on college students' performance on the recently published Wechsler Abbreviated Scale of Intelligence.
The role of stratotypes in stratigraphy: Part 3. The Wood Committee, the Berkeley school of North American mammalian stratigraphic paleontology, and the status of provincial golden spikes

Abstract The North American Land Mammal Ages, defined in 1941 by the Wood Committee, provide good examples of the use of strict nominal stratotypes in fixing the names and establishing the minimum durations of provincial biochronologic units. The lithostratigraphic “type sections” of each Age served a name-bearing and exemplary function, not a boundary-defining function. Despite some inconsistencies in their work, the common charge that the Wood Committee defined many of their Ages as lithochrons is a myth. Nevertheless, the potential or actual temporal overlap of some of the original nominal stratotypes of the Ages is a significant problem, and their redefinition is permissible in order to preserve the original intentions of the Wood Committee. The Berkeley school of North American mammalian stratigraphic paleontology has been the most influential force in theoretical discussions in this field since the 1960s. D.E. Savage retained most of the Oppelian views of R.M. Kleinpell, while M.O. Woodburne and D.R. Prothero departed from that tradition and adopted some of the views of H.D. Hedberg and W.A. Berggren, thus emphasizing single-taxon definitions, “datum-planes,” and boundary stratotype definitions for “stages.” However, recommendations by members of the Berkeley school that we turn our land mammal ages into “formal stages” are ironic because their own writings show they still hold the anti-Hedbergian view that “stages” are flexible biostratigraphic/biochronostratigraphic entities. Nevertheless, in partial agreement with at least some members of the Berkeley school, the transformation of our provincial biochronologic units into golden spike-defined Ages/Stages would defeat their purpose, which is to summarize our evolving knowledge of the true sequence of important paleobiological events in each major fossil group that occurred in a given province. In principle and in practice, Hedberg's attempt to restrict the terms Age/Stage to golden spike-defined entities has failed. However, Hedbergians and traditional stratigraphic paleontologists can find common ground if they will admit that aurichronologic and biochronologic units are both legitimate subcategories of geochronologic units. If so, Hedberg's major program would be vindicated in that golden spikes would still be used to define the Phanerozoic Standard Global Geochronologic Units, while traditional stratigraphic paleontologists would retain the ability to modify the boundaries of their provincial Ages/Stages as they saw fit, provided that such modifications did not violate the strict nominal stratotypes of those Ages/Stages.
High Performance Cooling and Large Scale Integration

Large scale integration has not invaded the highest performance regime of computation. The speed of circuits on LSI chips has not matched those available at lower levels of integration. The root of the difference is to be found in power; increases in number of components have not been accompanied by a proportionate increase in power per chip. The trade-off between power and speed means that the limited ability of technology to remove heat at high density from compact structures leads to a lower power dissipation per gate at higher levels of integrations and lower speed.
The Borderlands of Belief: Phil Rickman's Merrily Watkins Mysteries

Merrily Watkins is a highly unconventional Anglican priest and exorcist, and her eponymous mystery series represents the church she serves as hopelessly out of touch culturally and morally. Such di...
Mechanics of Emulsion Electrospun Porous Carbon Fibers as Building Blocks of Multifunctional Materials

Many multifunctional composite structures incorporate porosity at various length scales to increase the available surface area of a functional component. One material system of particular interest is activated or porous carbon fibers and nanofibers that can serve as structural reinforcement as well as providing active surface for added functionality. A key question in the design and manufacture of these fibers is to what degree the induced pore affects the mechanical properties by inducing discontinuities in the material. To address this problem, mechanics of porous carbon nanofibers (CNFs) was studied for the first time as a function of their porous structure. Hollow CNF with porous shell was prepared by coaxial electrospinning a polyacrylonitrile/poly(methyl methacrylate) (PMMA) blend shell with a PMMA core. PMMA was removed by thermal decomposition during pyrolysis to form pores. Solid-shell CNF was prepared as a control with no PMMA in the shell. Results show that the modulus and strength of the porous-shell CNF with a porosity of 19.2 ± 1.3% were 65.0 ± 6.2 and 1.28 ± 0.14 GPa respectively, 13.9 ± 2.1% and 35.5 ± 4.9% lower than those of the solid-shell CNF. Finite-element analysis models were developed to decouple the effect of stress concentration and reduced load-bearing area in porous CNFs on their mechanical properties. The model predictions were in general agreement with the experimental results and were used to identify the most critical parameters that can affect load bearing in porous nanofibers. Considering the comparison of the experimental and modeling results, the intrinsic material strength (of the solid parts) does not seem to be affected by inducing pores; thus, fiber and pore geometries might be developed where the load paths are designed for even less of a strength loss.
Magnetospheric Constellation: Leveraging Space 2.0 for Big Science

Earth's magnetosphere is a large magnetic cavity formed through the interaction of the solar wind and Earth's intrinsic magnetic field. Solar wind energy enters this cavity through a boundary - the magnetopause - separating Earth's field from the solar wind. This energy leads to many forms of “space weather”, including the aurora, geomagnetic storms, and energization of the Van Allen radiation belts. Despite decades of research, we still do not understand the extent of dayside reconnection sites, nor do we have a quantifiable understanding of how much energy enters the magnetosphere during different solar wind conditions - necessary for space weather prediction. On the nightside, impulsive flows at various spatial and temporal scales occur frequently during storms and substorms, and couple to the ionosphere through still unresolved physical mechanisms. Because the magnetosphere is so large, it has been understood since the dawn of the space age that a full understanding of this complex region could only be achieved with a large fleet of in situ spacecraft. NASA has studied one such constellation, the socalled “Magnetospheric Constellation” (MagCon), since the 1990's [1], but it is deemed too expensive to implement using traditional approaches. The CubeSat/SmallSat revolution represents a fundamental disruption to traditional mission architectures, and in this paper I will discuss how, by leveraging innovation in spacecraft subystems, advanced manufacturing, and access to space, we can finally realize this long-term vision of exploration and discovery. The proposed modular approach, utilizing rideshare and propulsive ESPAs, would also enable worldwide participation in the mission, and is applicable to any constellation mission, including Earth Science missions.
Q Fever in Southern California: a Case Series of 20 Patients from a VA Medical Center.

Coxiella burnetii is the obligate intracellular Gram-negative bacteria responsible for query fever (Q fever), which is known to cause acute and chronic infection in humans.1 The clinical manifestations of acute and chronic infection are often nonspecific and can be widely variable, which makes establishing the diagnosis challenging.1,2 Acute infection, although often nonspecific or even asymptomatic, can present with fever, myalgia, headache, or gastrointestinal symptoms, and chronic infection can range from granulomatous hepatitis, osteomyelitis, and pneumonia to endocarditis.1 Transmission is predominantly from direct contact with infected animals or their birth products, although multiple modes of transmission have been described in humans, including inhalation of contaminated wind-borne material from infected livestock and ingestion of unpasteurized dairy products.3–8 There have even been reports of sexual transmission of Q fever.9,10 The reservoirs for Q fever are thought to include both wild and domestic animals spanning many different species and may also include arthropods.8,11,12 However, most patients diagnosed with Q fever do not report any exposure to the known risk factors.13 Query fever was first described in 1935 in Queensland, Australia, and has since been reported in almost every country.14 Twelve years later, Frank Young described the first reported case of Q fever in Los Angeles County, where the dairy industry was flourishing and geographically concentrated.15 Subsequent studies conducted in southern California in the 1940s and 1950s, to better characterize the disease and its endemicity, associated Q fever with exposure to domestic livestock, mostly sheep, goats, and cattle.16,17 These studies reported that the largest number of serologically positive animals were from southern California, as compared with northern California, and suggested sheep and goats were primarily responsible for harboring the disease in the north, whereas cattle were predominantly responsible in the south.18,19 Not many studies on Q fever in southern California have been conducted recently, and to our knowledge, the most recent study was published in 2006 by Cone et al.,20 who described six cases of Q fever which presented over 32 years in the southern California desert. We describe the clinical presentation, geographic distribution, and risk factors of 20 patients diagnosed with Q fever at the Veterans Affairs (VA) Loma Linda Healthcare System from 2000 to 2016.
Who Are the Remaining Uninsured Sexual Minority Adults Under the Affordable Care Act

Abstract Purpose: The study objectives were to estimate the size of and to describe the population that remains uninsured in the United States by sexual orientation. Methods: Data on nonelderly adu...
Subtiligase-Catalyzed Peptide Ligation

Subtiligase-catalyzed peptide ligation is a powerful approach for site-specific protein bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic analysis of cellular N termini. Here, we provide a comprehensive review of the subtiligase technology, including its development, applications, and impacts on protein science. We highlight key advantages and limitations of the tool and compare it to other peptide ligase enzymes. Finally, we provide a perspective on future applications and challenges and how they may be addressed.
Variance swaps, volatility swaps, hedging and bounds under multi-factor Heston stochastic volatility model

In this paper, we consider volatility swap and variance swap when the underlying asset is described by a process with multiple stochastic volatility models. The model considered in this paper is th...
Correction to: Unequal Opportunity: School and Neighborhood Segregation in the USA

The original version of this article unfortunately contained an error. The author would like to correct the error with this erratum.
Food Allergy Symptom Self-Management With Technology (FASST) mHealth Intervention to Address Psychosocial Outcomes in Caregivers of Children With Newly Diagnosed Food Allergy: Protocol for a Pilot Randomized Controlled Trial.

Background: Approximately 2.4 million children in the United States suffer from food-induced anaphylaxis, a condition that is annually responsible for over 200 deaths and 200,000 emergency room visits. As a result, caregivers of children newly diagnosed with severe and life-threatening food allergic reactions experience clinically significant symptoms of psychological distress, including fatigue, anxiety, depressed mood, social isolation, and substantially reduced quality of life. Despite this recognition, there is a lack of caregiver-centered self-management interventions to address these concerns. Objective: In this protocol, we propose to develop and conduct feasibility testing of a technology-enhanced, self-management, mobile health, smartphone app intervention called Food Allergy Symptom Self-Management with Technology for Caregivers (FASST) designed to meet the psychosocial health needs of caregivers of children with a new diagnosis of food allergy. Methods: This pilot study uses qualitative work (Phase I) to inform a 4-week longitudinal randomized controlled trial (Phase II). In Phase I, 10 caregivers of children (≤18 years old) with established food allergy (≥1 year from diagnosis) will participate in semistructured interviews to inform the development of the FASST app. In Phase II, 30 caregivers of children (≤18 years old) with a newly diagnosed food allergy (≤90 days from diagnosis) will be randomized 2:1 to receive the FASST intervention (n=20) or control condition (basic app with educational resources; n=10). Process measures include feasibility, caregiver acceptability, adherence, and satisfaction. Outcome measures include caregiver fatigue, anxiety, depression, sleep, self-efficacy, and quality of life measured at baseline, week 4, and 3 months post study completion. Results: Phase I study activities have been completed, and Phase II participant enrollment into the randomized controlled trial is expected to commence in 2021. Conclusions: With limited readily available resources at their disposal, the results from this study have the potential to provide caregivers of children with a newly diagnosed food allergy a tool to help them self-manage and mitigate negative psychosocial factors during a critical time period in the caregiving/condition trajectory. Trial Registration: ClinicalTrials.gov Identifier NCT04512924: https://clinicaltrials.gov/ct2/show/NCT04512924
Heterogeneous Effects of Affordable Care Act Medicaid Expansions Among Women with Dependent Children by State-Level Pre-Expansion Eligibility.

Objectives: This study explores the heterogeneity in effects of the 2014 Affordable Care Act (ACA) Medicaid expansions on insurance coverage, health care access, and health status of low-income wom...
Endosalpingiosis Is Negative for GATA3.

Context.— Endosalpingiosis is a benign Mullerian inclusion that can mimic metastatic low-grade mammary carcinoma, particularly when encountered in axillary lymph nodes excised for breast cancer staging. Immunohistochemistry can be useful in histologically ambiguous cases, and a targeted immunopanel should include a marker of gynecologic tract origin and a marker of mammary origin. GATA3 is a sensitive immunomarker for breast carcinoma, but the immunoreactivity of GATA3 in endosalpingiosis has not been systematically evaluated. Objective.— To evaluate whether GATA3 immunohistochemistry could be used to differentiate endosalpingiosis from metastatic mammary carcinoma. Design.— Whole slide sections of 15 cases of endosalpingiosis involving nonneoplastic tissues were subjected to GATA3 immunohistochemistry. Nuclear GATA3 labeling was scored as percentage and intensity labeling, with any labeling considered positive; GATA3 labeling was recorded in all cells present in the sections. Results.— Half (47%, n = 7 of 15) of the endosalpingiosis cases involved lymph nodes (2 axillary, 5 pelvic) and half (53%, n = 8 of 15) involved pelvic organs or soft tissue (3 myometrial, 2 paratubal, 2 periadnexal soft tissue, and 1 pelvic sidewall). GATA3 immunohistochemistry was negative in all cases of endosalpingiosis, with intact, positive control labeling in lymphocytes. The benign fallopian tube epithelium present on the sections of paratubal endosalpingiosis displayed focal ( Conclusions.— These findings support the diagnostic utility of GATA3 immunohistochemistry and its use in a targeted immunopanel to resolve the differential diagnosis of metastatic low-grade mammary carcinoma (GATA3+) and nodal endosalpingiosis (GATA3-).
Update on the Role of Imaging in Clinical Staging and Restaging of Renal Cell Carcinoma Based on the AJCC 8th Edition, From the AJR Special Series on Cancer Staging.

This article reviews the essential role of imaging in clinical staging and restaging of renal cell carcinoma (RCC). To completely characterize and stage an indeterminate renal mass, renal CT or MRI...
Unveiling the histopathologic spectrum of MRI-guided breast biopsies: an institutional pathological-radiological correlation

Breast magnetic resonance imaging (MRI) has high sensitivity but suffers from low specificity, resulting in many benign breast biopsies for MRI-detected lesions. We sought to compare histologic findings between patients who underwent MRI-guided breast biopsy versus biopsy via other imaging modalities as well as to examine features associated with malignancy in the MRI cohort to help inform MRI-biopsy practice. A 2-year (2018–2019) retrospective review of breast biopsies at our enterprise was conducted. Biopsies were categorized as stereotactic, ultrasound, MRI, or palpation guided. Pathology was categorized as benign (further divided into nine categories), atypical, or malignant (subdivided into in situ and invasive carcinoma). Pathology was compared between biopsy groups. Clinical, pathologic, and imaging features were compared between pathology groups within the MRI cohort. 5828 biopsies from 4154 patients were reviewed, including 548 MRI-guided biopsies with stratification of MRI-biopsy pathology as follows: 69% benign, 13.8% atypical, and 17.2% malignant. Among benign MRI biopsies, there was higher frequency of “clustered cysts with papillary apocrine metaplasia” (56/548; 10.2%) and lower rate of fibroadenoma/fibroadenomatous change (55/548; 10%) compared to other modalities (158 or 3% and 1144 or 21.7% of 5280 biopsies, respectively). Multivariate analysis revealed indication of breast cancer (p < .0001), ipsilateral cancer (p < .0001) and rapid initial phase kinetics (p = .017) to remain significantly associated with malignant MRI-biopsy pathology. A concurrent or recent breast cancer diagnosis was most predictive of malignancy on MRI-guided breast biopsy. Combined MRI feature evaluation and radiologic-pathologic concordance activities may allow for prognostic refinement and improved risk stratification.
The Quest to Feel Good

Part I: Introduction. Introduction. The Z-Factor. Part II: Theoretical Foundations. The Evolutionary Imperatives. Individual Psychology: The Perspective of Alfred Adler. Physiological Foundations. Part III: Emotional Basics. Emotions, Feelings, and Motivation. Part IV: Validating Emotions. The Validating Emotions. Part V: The Compelling Emotions. Threat Emotions. The Protest and Fighting Emotions. Psychological Distancing Emotions. The Affiliation Emotions. The Withdrawing Emotions. Part VI: Treatment Uses. Emotional Reorientation: A Clinical Strategy. Appendix A: The Adaptive Purpose of Emotional Expression. Appendix B: Emotional Self-Control (Instructions). Appendix C: Emotional Self-Control (Worksheet). Appendix D: The Three Purposes of Emotion.
Genome-wide DNA methylation profiling in 40 breast cancer cell lines

DNA methylation plays important roles in gene regulation and functions. Aberrant methylation, either hypomethylation or hypermethylation, has been reported to cause various diseases, especially cancers. Breast cancer ranked the fifth according to the number of cancer deaths in the world. To systematically characterize the epigenetic modification in breast cancer, we examined the genome-wide methylation profiling in 40 breast cancer cell lines. We identified a gene signature consisting of 345 differentially methylated genes, which could be used to discriminate estrogen receptor (ER)-negative and ERpositive breast cancer cell lines. This gene signature is promising for diagnosis and therapies of breast cancer. In the follow up functional analysis of this gene signature, three enriched networks could be highlighted. Interestingly, one of these networks contained estrogen receptor, implying its functional importance of ER-centric module. Finally, we examined the correlation between methylation and expression of these breast cancer cell lines. Very few genes showed significant correlation, suggesting that gene expression regulated by methylation is a complex biological process.
Geographic Data Mining and Knowledge Discovery

Introduction Harvey J. Miller and Jiawei Han Spatiotemporal Data Mining Paradigms and Methodologies John F. Roddick and Brian G. Lees Fundamentals of Spatial Data Warehousing for Geographic Knowledge Discovery Yvan Bedard and Jiawei Han Analysis of Spatial Data with Map Cubes: Highway Traffic Data Chang-Tien Lu, Arnold P. Boedihardjo, and Shashi Shekhar NEW! Data Quality Issues and Geographic Knowledge Discovery Marc Gervais, Yvan Bedard, Marie-Andree Levesque, Eveline Bernier, and Rodolphe Devillers Spatial Classification and Prediction Models for Geospatial Data Mining Shashi Shekhar, Ranga Raju Vatsavai, and Sanjay Chawla An Overview of Clustering Methods in Geographic Data Analysis Jiawei Han, Jae-Gil Lee, and Micheline Kamber NEW! Computing Medoids in Large Spatial Datasets Kyriakos Mouratidis, Dimitris Papadias, Spiros Papadimitriou NEW! Looking for a Relationship? Try GWR A. Stewart Fotheringham, Martin Charlton, and Urska Demsar Leveraging the Power of Spatial Data Mining to Enhance the Applicability of GIS Technology Donato Malerba, Antonietta Lanza, and Annalisa Appice Visual Exploration and Explanation in Geography: Analysis with Light Mark Gahegan NEW! Multivariate Spatial Clustering and Geovisualization Diansheng Guo NEW! Toward Knowledge Discovery about Geographic Dynamics in Spatiotemporal Databases} May Yuan NEW! The Role of a Multitier Ontological Framework in Reasoning to Discover Meaningful Patterns of Sustainable Mobility Monica Wachowicz, Jose Macedo, Chiara Renso, and Arend Ligtenberg NEW! Periodic Pattern Discovery from Trajectories of Moving Objects Huiping Cao, Nikos Mamoulis, and David W. Cheung NEW! Decentralized Spatial Data Mining for Geosensor Networks Patrick Laube and Matt Duckham NEW! Beyond Exploratory Visualization of Space-Time Paths Menno-Jan Kraak and Otto Huisman
Sex‐dependent modulation of age‐related cognitive decline by the L‐type calcium channel gene Cacna1c (Cav1.2)

Increased calcium influx through L-type voltage-gated calcium channels has been implicated in the neuronal dysfunction underlying age-related memory declines. The present study aimed to test the specific role of Cacna1c (which encodes Cav1.2) in modulating age-related memory dysfunction. Short-term, spatial and contextual/emotional memory was evaluated in young and aged, wild-type as well as mice with one functional copy of Cacna1c (haploinsufficient), using the novel object recognition, Y-maze and passive avoidance tasks, respectively. Hippocampal expression of Cacna1c mRNA was measured by quantitative polymerase chain reaction. Ageing was associated with object recognition and contextual/emotional memory deficits, and a significant increase in hippocampal Cacna1c mRNA expression. Cacna1c haploinsufficiency was associated with decreased Cacna1c mRNA expression in both young and old animals. However, haploinsufficient mice did not manifest an age-related increase in expression of this gene. Behaviourally, Cacna1c haploinsufficiency prevented object recognition deficits during ageing in both male and female mice. A significant correlation between higher Cacna1c levels and decreased object recognition performance was observed in both sexes. Also, a sex-dependent protective role of decreased Cacna1c levels in contextual/emotional memory loss has been observed, specifically in male mice. These data provide evidence for an association between increased hippocampal Cacna1c expression and age-related cognitive decline. Additionally, they indicate an interaction between the Cacna1c gene and sex in the modulation of age-related contextual memory declines.
Mediator measurements during an artificial allergy season: Increased IL-5 and eosinophilic cationic protein (ECP) but no evidence of priming

Abstract Rationale The objectives of this study were to measure symptoms, IL4, IL5, IFN-γ, and ECP in subjects experiencing an artificial allergy season and to look for priming by comparing these values with those after a single instillation of allergen. Methods Twelve subjects received nasal instillation of an extract of relevant allergen out of pollen season at a dose that gave moderate symptoms and were then randomized to receive nasal allergen or to receive nasal saline daily over the next 7 days. Scrapings of nasal epithelium and nasal secretions were obtained at baseline, 24 hours after initial allergen administration, and 24 hours after the last instillation of allergen or saline. All subjects kept a log of daily symptoms. Results Subjects receiving nasal allergen extract had an increase in total symptom scores at day 9 compared with baseline (day 1) (p=0.007). IL5 protein was increased in the subjects who received nasal allergen extract compared with the subjects receiving nasal saline instillation (p=0.02); there was a trend towards increase in ECP in the subjects receiving allergen when compared with those receiving placebo ( p =.078). However, symptom scores, IL5 levels, and ECP levels were similar in subjects receiving nasal allergen at days 2 and 9. Conclusions An artificial allergy season is characterized by persistent symptoms and elevations of both IL5 and ECP. When symptom scores and mediator levels at day 2 and day 9 in the active allergen group were compared, we did not detect a priming effect due to daily instillation of allergen.
Modeling intragranular diffusion in low‐connectivity granular media

[1] Characterizing the diffusive exchange of solutes between bulk water in an aquifer and water in the intragranular pores of the solid phase is still challenging despite decades of study. Many disparities between observation and theory could be attributed to low connectivity of the intragranular pores. The presence of low connectivity indicates that a useful conceptual framework is percolation theory. The present study was initiated to develop a percolation-based finite difference (FD) model, and to test it rigorously against both random walk (RW) simulations of diffusion starting from nonequilibrium, and data on Borden sand published by Ball and Roberts (1991a,b) and subsequently reanalyzed by Haggerty and Gorelick (1995) using a multirate mass transfer (MRMT) approach. The percolation-theoretical model is simple and readily incorporated into existing FD models. The FD model closely matches the RW results using only a single fitting parameter, across a wide range of pore connectivities. Simulation of the Borden sand experiment without pore connectivity effects reproduced the MRMT analysis, but including low pore connectivity effects improved the fit. Overall, the theory and simulation results show that low intragranular pore connectivity can produce diffusive behavior that appears as if the solute had undergone slow sorption, despite the absence of any sorption process, thereby explaining some hitherto confusing aspects of intragranular diffusion.
Surface haptics via electroadhesion: Expanding electrovibration with Johnsen and Rahbek

This work aims to demonstrate and explain a nearly century old electrostatic haptic effect in human fingertips, which has since gone unreported. This effect, based on the original work of Johnsen and Rahbek [1], as well as research on electrostatic chucking devices [2], is capable of producing electrostatic forces on the finger an order of magnitude greater than those previously reported in literature. It is also capable of working with DC excitation, an aspect which stands out against previous reports which utilize purely AC excitation. This work also proposes a unified force model for this effect, drawn from electrostatic chuck research, and resolves this model with those in previous reports. We briefly discuss the background and specifics of the Johnsen-Rahbek effect, and include measurements made with our own electroadhesive surface and experimental apparatus. Finally, we discuss how this model fits in with previous observations, and its implications going forward.
The Rat Oncogenome: Comparative Genetics and Genomics of Rat Models of Mammary Carcinogenesis

The Norway rat has for many years been widely used as an experimental model for the study of breast cancer etiology and prevention. Mammary cancer can be induced in rats by a variety of agents. The mammary cancers that develop in the various rat models resemble in many respects the breast cancers that develop in humans. It is now clear that significant differences exist between different rat models with respect to the genetic bases of susceptibility to mammary cancer as well as the somatic genetic events that are associated with development of mammary cancer. In this review I summarize our current understanding of the genetic and genomics of mammary cancer in the rat, compare and contrast the genetic/genomic features of different rat mammary cancer models and discuss the relevance of these models to breast cancer in humans.
On-chip matched 5.2 and 5.8 GHz differential LNAs fabricated using 0.35 [micro sign]m CMOS technology

The authors have designed experimental 5.2 and 5.8 GHz low-noise amplifiers (LNAs) using 0.35 /spl mu/m CMOS technology. The ICs feature on-chip matching to 50 /spl Omega/, differential operation, and open drain output buffers. A return loss of better than -15 dB was achieved for both amplifiers. LC parallel resonant loads were used to form the gain peak. The LNAs had a measured noise figure of 4 to 5 dB, at VSS=3.3 V.
Haloperidol affects guinea pig chewing burst durations

Previous investigations have reported that most movement patterns in humans and other mammalian species are partitioned into 1–5-s units. This finding has led to the hypothesis that a highly conservat
Venous Thromboembolic Events After Spinal Fusion: Which Patients Are at High Risk?

Background: Postoperative venous thromboembolic events (VTEs), which include pulmonary emboli and deep venous thromboses, are potentially preventable causes of death. The aim of this study was to investigate the patient and procedure-related risk factors for the occurrence of VTEs in patients undergoing spinal fusion. Methods: We used ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification) procedure codes to identify patients in the Nationwide Inpatient Sample (NIS) database for 2001 through 2010 who were treated with spinal fusion. The occurrence of a symptomatic VTE was identified with use of ICD-9-CM diagnosis codes. Patient demographics, hospital characteristics, and comorbidities in the VTE and non-VTE groups were analyzed, and independent risk factors for VTE were identified. Results: A total of 710,154 spinal fusion procedures were identified in the NIS from 2001 to 2010, and 3525 (0.50%) of these patients were recorded as having 3777 VTEs, consisting of 2038 deep venous thromboses (0.29%) and 1739 pulmonary emboli (0.24%). Patients with a VTE were older on average (57.63 years compared with 52.88 years for patients without a VTE) and more often male (VTE incidence, 0.58% compared with 0.42% for female) and black (VTE incidence, 0.78% compared with 0.47% for white). Postoperative VTE occurrence was associated with a longer hospital stay (18.0 compared with 3.94 days) and higher total hospital charges ($207,253 compared with $66,823). A number of comorbidities and procedure-related factors were identified as independent risk factors for VTE. Conclusions: We present a VTE Risk Index, based on the independent risk factors identified in this study, for the VTE following spinal fusion. In conjunction with current guidelines, this risk index can be used to guide clinical decision-making regarding VTE prophylaxis in patients undergoing spinal fusion. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Zr-catalyzed diastereo- and enantioselective diene cyclizations. An unexpected synthesis of chiral aldehydes

Zr-catalyzed diastereo- and enantioselective intramolecular cyclizations that afford highly functionalized cyclopentyl structures that bear quaternary carbon centers are presented. Depending on the structure of the substrate diene, exceptional levels of diastereo- (>25:1) and enantioselectivity (>98% ee) can be attained. Furthermore, an unexpected observation is disclosed regarding the formation of aldehyde products (note that processes discussed herein require use of excess of a Grignard reagent). Experiments that shed light on this unusual observation are reported and discussed.