cssi/SciSciGPT-SciSciNet huggingface dataset:
Cluster-based approach to a multi-GPU CT reconstruction algorithm

Conventional CPU-based algorithms for Computed Tomography reconstruction lack the computational efficiency necessary to process large, industrial datasets in a reasonable amount of time. Specifically, processing time for a single-pass, trillion volumetric pixel (voxel) reconstruction requires months to reconstruct using a high performance CPU-based workstation. An optimized, single workstation multi-GPU approach has shown performance increases by 2–3 orders-of-magnitude; however, reconstruction of future-size, trillion voxel datasets can still take an entire day to complete. This paper details an approach that further decreases runtime and allows for more diverse workstation environments by using a cluster of GPU-capable workstations. Due to the irregularity of the reconstruction tasks throughout the volume, using a cluster of multi-GPU nodes requires inventive topological structuring and data partitioning to avoid network bottlenecks and achieve optimal GPU utilization. This paper covers the cluster layout and non-linear weighting scheme used in this high-performance multi-GPU CT reconstruction algorithm and presents experimental results from reconstructing two large-scale datasets to evaluate this approach's performance and applicability to future-size datasets. Specifically, our approach yields up to a 20 percent improvement for large-scale data.
Tracheal activity recognition based on acoustic signals.

Tracheal activity recognition can play an important role in continuous health monitoring for wearable systems and facilitate the advancement of personalized healthcare. Neck-worn systems provide access to a unique set of health-related data that other wearable devices simply cannot obtain. Activities including breathing, chewing, clearing the throat, coughing, swallowing, speech and even heartbeat can be recorded from around the neck. In this paper, we explore tracheal activity recognition using a combination of promising acoustic features from related work and apply simplistic classifiers including K-NN and Naive Bayes. For wearable systems in which low power consumption is of primary concern, we show that with a sub-optimal sampling rate of 16 kHz, we have achieved average classification results in the range of 86.6% to 87.4% using 1-NN, 3-NN, 5-NN and Naive Bayes. All classifiers obtained the highest recognition rate in the range of 97.2% to 99.4% for speech classification. This is promising to mitigate privacy concerns associated with wearable systems interfering with the user’s conversations.
Synchronous Rotation in the Eclipsing Binary 68 Herculis Inferred from Doppler Shifts in its Spectrum and Light Curve Modeling

Our differential photometry of the eclipsing binary 68 Herculis through V- and R-filters shows periodic minima consistent with a previously established period. As a function of its orbital motion, we report spectra over a limited wavelength range encompassing H-alpha 656.3 nm and helium 667.8 nm lines. Doppler shifts of both stars were resolved in H-alpha, while only the more massive star rendered the helium line with Doppler shifts that agree with the radial velocity we derive for it from the H-alpha profile. Sinusoidal curve-fits to the orbital dependence of the radial velocities imply circular orbits for both components, with amplitudes indicating a mass ratio for the two stars in agreement with published values. A subtle Doppler shift associated with stellar rotation is evident in the radial velocity of the primary component as its eclipse commences; modeling indicates this rotation is synchronous with the orbital revolution, an expected tidal effect of near-contact binary systems.
Mapping Wonderlands: Illustrated Cartography of Arizona, 1912–1962

Dori Griffin. Tucson, AZ: University of Arizona Press, 2013. ix and 219 pp., illustrations, notes, appendix, index. $55.00 cloth (ISBN 978-0-8165-0932-4).In the late nineteenth century, tourism ind...
Endoparasites of American marten (Martes americana): Review of the literature and parasite survey of reintroduced American marten in Michigan

The American marten (Martes americana) was reintroduced to both the Upper (UP) and northern Lower Peninsula (NLP) of Michigan during the 20th century. This is the first report of endoparasites of American marten from the NLP. Faeces from live-trapped American marten were examined for the presence of parasitic ova, and blood samples were obtained for haematocrit evaluation. The most prevalent parasites were Capillaria and Alaria species. Helminth parasites reported in American marten for the first time include Eucoleus boehmi, hookworm, and Hymenolepis and Strongyloides species. This is the first report of shedding of Sarcocystis species sporocysts in an American marten and identification of 2 coccidian parasites, Cystoisospora and Eimeria species. The pathologic and zoonotic potential of each parasite species is discussed, and previous reports of endoparasites of the American marten in North America are reviewed.
Genetic manipulation of forest trees: implications for physiological processes.

With the recent advances in biotechnology of woody perennials (Durzan, 1988ab, 1989, 1990; Hallgren, 1988; Haissig et al, 1987; Torrey, 1988), considerable interest has developed in gene expression, particularly as transgenic trees are being regenerated. Progress in physiological aspects of biotechnology is evaluated against current schemes for domestication and tree improvement (Haissig et al., 1987; Timmis et al., 1986). An attempt is made to illustrate how elite or foreign genes may be expressed in quantitative terms against different genetic backgrounds. Notions from metabolic control theory involving preconditioning factors become useful, especially when examining the rejuvenation of cells for clonal propagation and gene insertion. The general area involving gene manifestation, penetrance and expressivity has been termed molecular phenogenetics (Durzan, 1990).
Simonian Bounded Rationality and Complex Behavioral Economics

This chapter will consider the importance of Herbert A. Simon as both the discoverer of the idea of bounded rationality and its role in modern behavioral economics and as one of the early developers of complexity theory, especially its hierarchical and computational forms. Bounded rationality was essentially derived from Simon’s view of the impossibility of full rationality on the part of economic agents. Modern complexity theory through such approaches as agent-based modeling offers an approach to understanding behavioral economics by allowing for specific behavioral responses to be assigned to agents who interact within this context, even without full rationality. Other parts of modern complexity theory will also be considered in terms of their relationships with behavioral economics. Fundamentally, complexity provides an ultimate foundation for bounded rationality and hence the need to use behavioral economics.
Percutaneous Rescue for Critical Mitral Stenosis Late After Mitral Valve Repair

We report a case of catastrophic hemodynamic compromise secondary to pannus ingrowth and severe mitral stenosis occurring years after repair of a nonrheumatic mitral valve. The initial repair included closure of a posterior leaflet cleft and implantation of an annuloplasty ring. We describe a hybrid treatment strategy for this severely compromised patient, which included initial placement of a right ventricular assist device followed by percutaneous balloon mitral valvuloplasty and, eventually, a definitive mitral valve reoperation. This case report reinforces the importance of routine clinical and echocardiographic follow-up for patients after mitral valve repair, and it includes the description of a novel therapeutic approach.
Shape-Adaptable Polymeric Particles for Controlled Delivery

Environmentally triggered shape reconfiguration is ubiquitous in biological systems and a key parameter in developing “intelligent” materials capable of various function-oriented adaptations. While significant progress has been made in developing shape memory in “bulk” macroscale polymer materials, only a few examples of shape adaptability can be found in polymeric micro- and nanoparticles. In biotechnology and nanomedicine, though, morphological and shape adaptations of drug carriers offer unique opportunities in controlling shape-guided interactions with cells, vascular dynamics, transport across biobarriers, and recognition functions. Yet, unlike extensive studies on other physicochemical aspects of stimuli-responsive particle behavior, such as size, composition, surface morphology, permeability, swelling, and rigidity, the phenomenon of shape alteration in macro- and nanosized particulates has rarely been explored. This Perspective highlights recent developments in the field of polymer particulates su...
Bile acid: a potential inducer of colon cancer stem cells.

Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promote stemness in colonic epithelial cells leading to generation of cancer stem cells (CSCs) that play a role in the development and progression of colon cancer. Normal human colonic epithelial cells (HCoEpiC) were used to study bile acid DCA/LCA-mediated induction of CSCs. The expression of CSC markers was measured by real-time qPCR. Flow cytometry was used to isolate CSCs. T-cell factor/lymphoid-enhancing factor (TCF/LEF) luciferase assay was employed to examine the transcriptional activity of β-catenin. Downregulation of muscarinic 3 receptor (M3R) was achieved through transfection of corresponding siRNA. We found DCA/LCA to induce CSCs in normal human colonic epithelial cells, as evidenced by the increased proportion of CSCs, elevated levels of several CSC markers, as well as a number of epithelial–mesenchymal transition markers together with increased colonosphere formation, drug exclusion, ABCB1 and ABCG2 expression, and induction of M3R, p-EGFR, matrix metallopeptidases, and c-Myc. Inhibition of M3R signaling greatly suppressed DCA/LCA induction of the CSC marker ALDHA1 and also c-Myc mRNA expression as well as transcriptional activation of TCF/LEF. Our results suggest that bile acids, specifically DCA and LCA, induce cancer stemness in colonic epithelial cells by modulating M3R and Wnt/β-catenin signaling and thus could be considered promoters of colon cancer.
Adaptive synchronization of networked multi-agent systems considering transient responses and disturbances

Networks of mechanical drive systems require precise and robust regulation of the position and speed relations at specified synchronized ratios. Successful synchronization of the multi-agent systems can provide complex mechanisms like powertrain drives or precision machines with enhanced efficient and effective performances. In this paper a new adaptive tracking and synchronization controller is presented to achieve robust tracking and synchronization performance under modeling errors and disturbances. The presented methodology combines a synchronization method of networked systems and model reference adaptive control theories considering uncertainties. Improved transient and steady-state system performances are validated through application of the proposed architecture to DC servo motor systems.
Immunotherapy in Urothelial Cancer: Recent Results and Future Perspectives

Cytotoxic chemotherapy has been the only systemic treatment of locally advanced and metastatic urothelial carcinoma for decades. Long-term survival remains stagnant around 12–14 months for patients with advanced disease who have progressed on or recurred after receiving first-line platinum-based chemotherapy. Improving clinical outcomes for patients with urothelial carcinoma in all disease settings requires the development of novel treatments, especially for patients who failed on first-line chemotherapy. Since the discovery of intravesical Bacillus-Calmette Guerin (BCG) in the 1970s for non-muscle invasive disease, there have not been any major breakthrough drugs that exploit the immune-sensitivity of bladder cancer until recently. Immune-checkpoint inhibitors targeting the programmed death 1/programmed death-ligand 1 (PD-1/PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathways have shown significant anti-tumor activity, tolerable safety profiles and durable, long-term responses in clinical trials. Atezolizumab, avelumab, durvalumab, nivolumab and pembrolizumab are promising PD-1/PD-L1 blockade drugs under investigation that will redefine the standard of care for bladder cancer. CTLA-4 inhibitors are also under investigation in this setting. Atezolizumab, approved in May 2016, and nivolumab, approved in February 2017, are the first Food and Drug Administration (FDA)-approved immune-checkpoint inhibitors in bladder cancer for platinum-pretreated patients based on phase II data. On March 16, 2017, results from the phase III trial KEYNOTE-045 demonstrated that survival was significantly longer in patients treated with pembrolizumab when compared with the standard second-line chemotherapy. Research into biomarkers such as PD-L1 expression, messenger RNA subtype, mutational and neoantigen load and gene signature expression will be crucial to determining why some patients respond to immunotherapy and others do not. This review article describes the advances in immunotherapy since the development of BCG, presents results from clinical trials investigating immune-checkpoint inhibitors and discusses biomarkers and prognostic factors associated with response to these new drugs.
Challenges to teaming for pain in primary care.

Better understanding task distribution related to chronic pain assessment and management can help improve team-based pain care.
Review of Extraskeletal Activity on Tc-99m Methylene Diphosphonate Bone Scintigraphy and Value of Cross-Sectional and SPECT-CT Imaging Correlation

Recognizing the different mechanisms and imaging appearance of extraskeletal Tc-99m methylene diphosphonate uptake enhances the diagnostic value of bone scan interpretation. In this article, we present a pictorial review of the different mechanisms of extraskeletal Tc-99m methylene diphosphonate uptake on bone scintigraphy including neoplastic, inflammatory, ischemic, traumatic, excretory, and iatrogenic. We also illustrate through case examples the added value of correlation with cross-sectional and single photon emission computed tomography and computed tomography imaging in localizing and characterizing challenging cases of extraskeletal uptake.
Benchmarking keystroke authentication algorithms

Free-text keystroke dynamics is a behavioral biometric that has the strong potential to offer unobtrusive and continuous user authentication. Such behavioral biometrics are important as they may serve as an additional layer of protection over other one-stop authentication methods such as the user ID and passwords. Unfortunately, evaluation and comparison of keystroke dynamics algorithms are still lacking due to the absence of large, shared free-text datasets. In this research, we present a novel keystroke dynamics algorithm, based on kernel density estimation (KDE), and contrast it with two other state-of-the-art algorithms, namely Gunetti & Picardi's and Buffalo's SVM algorithms, using three published datasets, as well as our own new, unconstrained dataset that is an order of magnitude larger than the previous ones. We modify the algorithms when necessary such that they have comparable settings, including profile and test sample sizes. Both Gunetti & Picardi's and our own KDE algorithms have performed much better than Buffalo's SVM algorithm. Although much simpler, the newly developed KDE algorithm is shown to perform similarly as Gunetti & Picardi's algorithm on the three constrained datasets, but the best on our new unconstrained dataset. All three algorithms perform significantly better on the three prior datasets, which are constrained in one way or another, than our new dataset, which is truly unconstrained. This highlights the importance of our unconstrained dataset in representing the real-world scenarios for keystroke dynamics. Lastly, the new KDE algorithm degrades the least in performance on our new dataset.
Causal Effect Estimation and Inference Using Stata

Terza (2016b, Health Services Research 51: 1109–1113) gives the correct generic expression for the asymptotic standard errors of statistics formed as sample means of nonlinear data transformations....
Deep-Sea Hydrothermal Vents

Discovered only in 1977, hydrothermal vents are deep-sea hot springs rich in inorganic electron donors and CO2; they are generally located on the mid-ocean ridge spreading centers and other tectonically active areas. Seawater circulates through cracks and conduits in the subsurface rock and is chemically altered into anoxic vent fluid rich in sulfide, CO and CO2, reduced metals, reduced carbon (methane), and hydrogen. Through chimney-like conduits of precipitated metal sulfides, the vent fluids emerge into the deep-sea water column as dark clouds – the ‘black smokers’. Vent bacteria and archaea use the hydrothermal electron donors as energy sources for chemolithotrophic metabolism, either as free-living microorganisms or as chemosynthetic endosymbionts of specialized invertebrates. Thus, deep-sea hydrothermal vents are chemosynthetically based ecosystems, in contrast to photosynthetic life on the earth’s surface. Their only geochemical link with the earth’s surface is the requirement for oxygen or nitrate by most chemolithoautotrophic bacteria. Deep-sea hydrothermal vents harbor the most thermophilic life forms; hyperthermophilic, generally anaerobic vent archaea thrive at temperatures near and above 100 °C, and are candidates for life in the vent subsurface. The distinct chemical regimes of different vent sites are reflected in their specific communities of uncultured and cultured bacteria and archaea; cultivations continue to yield novel isolates and metabolisms.
Role of glucagon in countering hypoglycemia induced by insulin infusion in dogs.

The aim of the present study was to characterize the role of glucagon in countering the prolonged hypoglycemia resulting from insulin infusion and to determine whether its effect is manifest throug...
Cell adhesion molecules and endometriosis

The pathogenesis of endometriosis remains poorly defined. The interaction of endometrium with peritoneum is an important aspect of the disease process. Cell adhesion molecules (CAMs) are transmembrane receptors that facilitate intercellular binding and cellular interaction with the extracellular matrix (ECM). CAMs and components of the ECM are divided into large families based on sequence homology and similarity of tertiary structures. The function of eutopic and ectopic endometrial CAMs has been a focus of recent studies concerning the pathogenesis of endometriosis. Specific alterations in endometrial and peritoneal CAMs could facilitate binding of reflux menstruated endometrium at ectopic sites. In addition, the expression of CAMs by endometriotic lesions has been investigated to help understand mechanisms involved in the maintenance of endometrial tissue in ectopic locations. An understanding of the mechanisms involved in the interaction of endometrium with peritoneal tissues may provide new strategies to prevent endometriotic implants from forming and help treat existing lesions.
The Future of a Killer

The first, documented 100 years of cerebrospinal meningitis, during which the clinical course and worldwide occurrence of diseases were vividly described, was dominated by attempts at symptomatic and “alexipharmic”—antidote—therapy. That approach did little to alter the natural course and invariably fatal conclusion to this devastating disease. By the time that the clinical entity—now understood to be meningococcal meningitis—entered its second century, the body of knowledge in the sister sciences of microbiology and immunology had evolved to such a degree that it could support rigorous laboratory and clinical investigations of infectious diseases. This led to research—initially and largely carried out in the Institutes of the great cities of Europe—Paris, Vienna, and Berlin—but later advanced in New York, resulting in the first effective therapy for meningococcal disease. By 1907, the mortality rate would drop from 75 to 30 %; physicians and scientists around the world felt as if they now had some measure of control against the infection.
Models to Study Glioma Cell Invasion

Gliomas represent the most common primary intracranial tumors. The aggressive clinical behavior of these tumors stems from the highly invasive properties of neoplastic glial cells. Fundamental to the development of an effective clinical treatment is the need to therapeutically target this invasive potential. Research into the mechanisms of invasion is imperative to better understand the various biological processes that could be targeted to treat the invading glioma cells. Such research is ideally conducted with reliable and relevant models. We describe some of the most commonly used models in glioma invasion research. Each model has its benefits and drawbacks and the nature of the experiments being conducted will help choose the type of model most suitable.
Mechanical and Tribological Behaviors

This chapter reviews fatigue, fracture, and biotribological actions, such as friction, wear, and wear debris toxicity. Materials in bioengineering range widely from very small units, such as a virus or bacteria, to very large and complex units, such as a healthy human body. They also cover the various products manufactured by using the methodologies in connection with biological disciplines. Fatigue is the loss of strength and other important properties as a result of stressing over a quite long period of time. It is very important, as it is the single largest cause of failures in metals, estimated as about 90% of the metallic failures. Polymers and ceramics are also susceptible to this type of failure. The mechanical environments related to fatigue are divided into two distinct groups: strain-controlled and stress-controlled. Clasps can undergo permanent deformation to cause fatigue fracture under repeated flexures during the denture insertion and removal, and masticatory actions. Permanent deformation and fatigue fracture are caused by the stress created in the clasp.
Photosynthesis and the web: 2001

First, a brief history of the Internet and the World Wide Web is presented. This is followed by relevant information on photosynthesis-related web sites grouped into several categories: (1) large group sites, (2) comprehensive overview sites, (3) specific subject sites, (4) individual researcher sites, (5) kindergarten through high school (K-12) educational sites, (6) books and journals, and, 7) other useful sites. A section on searching the Web is also included. Finally, we have included an appendix with all of the web sites discussed herein as well as other web sites that space did not allow. Readers are requested to send comments, corrections and additions to gov@uiuc.edu.
Breathing mode of a skyrmion on a lattice

The breathing modes of a skyrmion, corresponding to coupled oscillations of its size and chirality angle, are studied numerically for a conservative classical-spin system on a $500\ifmmode\times\else\texttimes\fi{}500$ lattice. The dependence of the oscillation frequency on the magnetic field is computed for a model with Dzyaloshinskii-Moriya interaction. In accordance with previous works, it is linear at small fields, reaches maximum on increasing the field, then sharply tends to zero as the field approaches the threshold above which the skyrmion loses stability and collapses. Physically transparent analytical model is developed that explains the results qualitatively and provides the field dependence of the oscillation frequency that is close to the one computed numerically. Dissipation of a breathing motion in which the skyrmion chirality angle $\ensuremath{\gamma}$ is rotating in one direction depends on the initial amplitude. Below a certain threshold the mode is stable, while above that threshold it becomes strongly damped by the reservoir of spin waves and quickly ends with the skyrmion collapse. To the contrary, smaller-amplitude breathing motion in which $\ensuremath{\gamma}$ oscillates is undamped in the absence of other interactions. Adding perpendicular anisotropy and removing the applied field makes the breathing mode of any amplitude very slow and undamped.
PERTINENCE OF SURFACE MEMBRANE CHANGES IN SPONTANEOUSLY AND VIRALLY TRANSFORMED CELLS TO THE BALANCE BETWEEN TUMORIGENICITY AND IMMUNE REJECTION

Spontaneously transformed highly tumorigenic AL/N strain mouse cells and their SV40 virus transformed clonal derivatives were compared. Glycoproteins were labeled by various metabolic precursors (amino acids, glucosamine, mannosamine, etc.). The flow of such labels into various subcellular components was followed. Cell surface membranes were obtained and the components of these membranes were separated by polyacrylamide gel electrophoresis. The biosynthesis of a prominent glycoprotein component with an apparent molecular weight of 180 K dalton was reduced in the SV40 transformed cells, when all the different kinds of cells were grown in their logarithmic phase. Three types of SV40 specific antigens were detected by immunologic assays: (1) T antigens, (2) tumor specific surface antigens (TSSA), and (3) tumor specific transplantation antigens (TSTA). A rapid and sensitive microassay for TSSA guided the development of a mild and efficient detergent (Triton X-100) solubilization technique, and the purification of the antigens that appear to co-purify in various procedures. The antigens expressed on the cell surface that are responsible for immunologic recognition and rejection of the SV40 transformed cells represented a very minor fraction of the cell surface membrane components. The microassay for TSSA allowed partial purification and characterization of the SV40 specific cell surface antigen (s). The(se) SV40 specific cell surface antigen (s) in the AL/N strain mouse functionally opposes cellular tumorigenicity.
Duplex phase hexagonal-cubic multi-principal element alloys with high hardness

Abstract We report on the influence of Mn additions on the microstructure and properties of (CoCrCuTi)100−xMnx multiprincipal element alloys (MPEAs) containing 5, 10, 15, and 20% Mn prepared by arc-melting. It was observed that the alloys containing less than 10 at.% Mn contained BCC dendrites and a Cu-rich face centered cubic (FCC) interdendritic matrix. In contrast, alloys containing Mn ≥ 10 at.%, consisted of a hexagonal dendritic Laves phase (C14, hexagonal, P63/mmc) with small amounts of Cr-rich and Ti-rich dendrites, and a Cu-rich FCC interdendritic matrix. Isopleths of the CoCrCuMnTi system were generated using the ThermoCalc software with TCHEA3 database in order to elucidate phase formation in these alloys. In addition, the particular composition Co22Cr18Cu20Mn16Ti24 was found to consist of Laves C14 phase hexagonal dendrites in a Cu-rich FCC interdendritic matrix with very small dispersed Ti-rich dendrites. Selected area electron diffraction of the dendritic phase in Co22Cr18Cu20Mn16Ti24 was found to have lattice parameters approximated to be a = 4.8A and c = 7.5A based on fitting the d-spacing of the indexed patterns to previously published data on the Cr2Ti intermetallic phase. The Vickers mircohardness of the hexagonal dendritic phase of Co22Cr18Cu20Mn16Ti24 was found to be 996.6 ± 57.2 HV 0.01, while the Cu-rich interdendritic matrix has hardness of 457.3 ± 7.0 HV 0.01 and overall hardness of both regions equaling 480.2 ± 21.4 HV 1. The overall Rockwell hardness was found to be 43 ± 2 HRC. The compressive strength of Co22Cr18Cu20Mn16Ti24 was measured to be 1430 MPa, while wear rate was measured as 2.64 × 10−5 mm3/m·N.
Critically examining white racial identity and privilege in sport psychology consulting.

Recently, there has been an increased effort to establish multicultural training programs for consultants working with diverse athlete populations. Although several authors have suggested that one aspect of such training is the examination of one’s biases related to race (Andersen, 1993; Martens, Mobley, & Zizzi, 2000), a systematic means of doing so has not yet been adequately discussed. In this article, I briefly discuss the field of whiteness studies, and the process of confronting what McIntosh (1988) has termed the “invisible knapsack of white privilege.” I then present the results of a life-history interview with a white male consultant, in which we discussed his changing sense of racial awareness and how he views his own white racial identity and the privileges associated with it. Finally, I discuss the results of a three-way discussion between myself, the consultant, and an African-American graduate student in sport psychology and present a preliminary account of white privileges specific to the a...
Research Questions regarding Undergraduate TA and Mentor Programs in Computer Science

Undergraduates have been an important part of the teaching staff at many universities for decades. Recent work such as the Peer Teaching Summit at SIGCSE 2019 [1] and a systematic literature review [2] have focused more attention on issues related to the use of undergraduates in teaching assistant roles. This BOF provides a forum to discuss open research questions about undergrad TA/mentor programs at various stages in their evolution. Attendees will have an opportunity to discuss research questions, research methods, and explore possible collaborations. Discussion Leader(s): Diba Mirza will open the session by summarizing the key findings of literature review on UTAs from ICER'19 [1]-in particular, the fact that while there is widespread consensus that using UTAs is a good idea, the evidence backing up this consensus is mostly anecdotal. This creates many opportunities to establish the effectiveness of current practices, and the claimed benefits of the use of UTAs through more rigorous research and to discuss innovative ways to incorporate UTAs in teaching outside of what has been reported in the literature. This will be followed by a themed discussion to brainstorm about research within each of these areas. Based on the large turnout at the BOF on Undergraduate Teaching Assistants in SIGCSE'19, we plan to organize the discussion in smaller groups. Diba Mirza, Phillip Conrad, and Cynthia Lee will lead the discussion within each group. The leads will also document the discussions and share it with the participants.
Peripheral Neuroblastic Tumors Of The Adrenal Gland: Clinicopathologic Features And Important Molecular Alterations

Abstract Peripheral neuroblastic tumors are the most common extracranial solid tumor of childhood and commonly present as an adrenal mass in a young child. This group of tumors is notable for wide clinical heterogeneity and variable clinical outcome. Peripheral neuroblastic tumors are defined by the amount of Schwannian stroma and degree of neuroblastic differentiation and categorized by the International Pathology Neuroblastoma Committee (INPC) as neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Molecular testing remains critical for risk stratification of patients. Important prognostic factors include age, stage, histologic classification, and amplification of MYCN. Advancements in our understanding of clinical and biologic prognostic factors continue to provide valuable knowledge for risk stratification and potential therapeutic targets.
The Effects of Converting Enzyme Inhibition

Several compounds have been discovered or created that inhibit angiotensin converting enzyme and thereby dramatically slow the conversion of angiotensin I to angiotensin II. One of these, captopril, has been widely used as an experimental tool and is currently being evaluated for routine clinical use because it can be administered orally.
A Moral Defense of Trophy Hunting and Why It Fails

This is a critique of Timothy Hsiao’s ‘A Moral Defense of Trophy Hunting.’ I argue that Hsiao’s arguments on pain, consciousness, behavior, cruelty, and necessity all fail. More importantly, I argu...
Ensemble-Guided Tropical Cyclone Track Forecasting for Optimal Satellite Remote Sensing

Within the realm of satellite remote sensing, optimal data acquisition to study natural phenomena under time, resource, and cost constraints is a well-known problem. Furthermore, since the sensors themselves are at remote locations with sparse ground connectivity, the optimal method must use a computationally light forecasting algorithm, which assimilates information from the observations at possibly irregular intervals, in near real time. In this article, we propose and demonstrate the ensemble -guided cyclone track forecasting (EGCTF) method for application in remote tropical cyclone tracking. The algorithm uses ensemble data produced by numerical weather prediction models to guide the forecasting process while assimilating measured cyclone center positions. The algorithm was tested and analyzed with the Global Ensemble Forecasting System (GEFS) data and the National Hurricane Center data for the 2018 year hurricanes within the Atlantic basin. Compared with a baseline method that uses the GEFS-issued mean ensemble track (AEMN) for forecasting and no data assimilation, the proposed algorithm exhibited positive forecast skill for more than 290 test cases over forecast periods spanning 6–48 h. The skill is seen to improve with lengthening forecast periods, with five test cases showing greater than 75% skill for a forecast period of 6 h to 247 test cases for the forecast period of 48 h.
Gestational diabetes and childhood asthma in a racially diverse US pregnancy cohort

BACKGROUND Childhood asthma is a common chronic disease that likely has prenatal origins. Gestational diabetes alters maternal physiology and may influence fetal risk for childhood-onset disease. However, the association between gestational diabetes and child asthma is not well characterized. OBJECTIVE To investigate the association between gestational diabetes and wheeze/asthma at approximately 4 years of age in a racially diverse US cohort. METHODS We studied mother-child dyads enrolled prenatally in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. Gestational diabetes was determined by medical chart review. At approximately 4 years of age, we assessed child respiratory outcomes including parent report of physician-diagnosed asthma (ever), current wheeze (symptoms within the past 12 months), and current asthma (physician diagnosis and/or medication or symptoms within the past 12 months). We used the modified Poisson regression to assess associations between gestational diabetes and child respiratory outcomes, adjusting for maternal age, race, prenatal smoking, pre-pregnancy body mass index, parity, asthma history, socioeconomic status, and infant sex. RESULTS Among 1107 women, 66% were African American/Black. Six percent (n = 62) had gestational diabetes documented during pregnancy. Gestational diabetes was associated with increased risk of physician-diagnosed asthma (adjusted risk ratio (RR) [95% Confidence Interval]: 2.13 [1.35, 3.38]; prevalence: 14%), current wheeze (RR: 1.85 [1.23, 2.78]; prevalence: 19%), and current asthma (RR: 2.01 [1.30, 3.10]; prevalence: 16%). CONCLUSIONS Gestational diabetes was associated with increased risk of asthma and wheeze outcomes. Additional studies are needed to elucidate modifiable pathways underlying this association.
Submitting to Specialty Law Reviews and Journals in Gender, Women & Sexuality

This paper, originally published in the Green Bag 2d, contains bibliographic-style information about 29 U.S.-based law reviews and journals classified under the subject "Gender, Women and Sexuality" by the Washington & Lee Law Journal Rankings. This information will be of substantial relevance anyone working in legal education who publishes scholarship in these areas. SSRN has eJournals dedicated to "Legal Information & Technology," the "Practice of Law Librarianship," and "Law Educator: Courses, Cases & Teaching Materials eJournal." This publication will be useful for professors who are guiding students in submitting for publication seminar papers or independent study projects that take the form of a scholarly paper. SSRN regularly publishes as "Scholarly Papers" bibliographies and other law review submission information. Nevertheless, SSRN has declined to treat an unpublished version of this material as a "Scholarly Paper." This practice is inconsistent with SSRN's self-stated mission, and so the guide is updated here from time to time.
Copper deficiency myeloneuropathy with a history of malabsorption: a tale of two cases.

Acquired copper deficiency is rare but often seen among patients with intestinal malabsorption syndromes. Often times, these patients can develop myeloneuropathies with copper deficiency as an elus...
An unusual complication of culdoscopy.

Abstract A case has been presented of prolapse of two appendices epiploicae in a patient following her second culdoscopic examination.
Non-contact ultrasonic imaging for post-tensioned bridges to investigate corrosion and void status

Corrosion of the nation's transportation infrastructure is a widespread and costly problem. Recent corrosion problems in post-tensioned bridge structures have increased the need for a reliable method for determining grout voids and level of corrosion in post-tensioned tendons. Corrosion monitoring techniques such as half-cell potential and corrosion rate measurements face problems when used in this type of structure and standard NDE (nondestructive evaluation) methods such as impact-echo have also encountered problems. This study begins the evaluation of a method called C-Scan ultrasonic imaging to evaluate grouted post-tensioned tendons. While this paper focuses on post-tensioning applications, the C-Scan technique may be valuable for investigation of any type of reinforced concrete structure.
Cultivating a Sense of Place in Religious Studies

This essay analyzes student learning through place-based pedagogies in an American Religions course. In the course, students analyzed cultural meanings and practices of regional religious communities and participated in sensory awareness and ecological learning in a campus garden. Embodied learning increased student understanding and appreciation of land-based religious practices and epistemologies, and promoted multiple student literacies. In Religious Studies, place-based learning is vital to the examination of the rich dimensions and expressions of religious experience. Across disciplines, place-based pedagogies can expand and deepen text-based learning, cultivate recognition of various ways of knowing, foster affective connections to the local community, and develop critical skills for addressing patterns of displacement and ecological denigration.
DISABILITIES MISCONCEPTIONS AND EMPLOYMENT: INTEGRATING ADVOCACY PERSPECTIVE AND REHABILITATION

This a rt icle r ev i ews th e lit e r a t ure o n misconc ept io n s h e ld by e mpl oy er s a nd bu s in esses a b o ut p e ople with di s abilit ies, w hi c h co n s t i tut es b a rr ie r s to th e ir f ull wo rkpla ce parti c ip a ti o n . D esig n e d to pr ov ide fo r th e e limin a ti o n of d iscri m ina t io n a gai n s t indi v idu a l s wi th d is abilit ies, th e A m e ri ca n s with Disa bilit ies Act ( AD A) m ore s ign ifi c a ntl y pr ovi d e d fo r impr ov in g their e mp loy m e nt o pp o rtuniti es. E n ac t ed a d ec ad e ago in 1 990 , th e A D A, how e ve r , h as no t m ove d fas t e n o u g h in i n c r eas in g e mpl oy m e n t o p p ortunit ies fo r m a n y o f it s in te n de d p o pul a ti o n s. Th is a rticle di sc u sses de m ogra ph y o f p eo pl e wi th d is abiliti es, e mpl oy ment i ss ue s, and mi sco n ce pti o n s a ssoc iat e d w ith d isa b i liti es. It di sc u sses int eg rat i n g an a d vocacy p e r s p ec t ive i n rehabilitat ion co un se l i n g. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;}
Uniqueness in the Cauchy problems for higher order elliptic differential operators

In this note, we study the uniqueness in Cauchy problems for a class of higher order elliptic differential operators with Lipschitz coefficients. In particular, we prove the uniqueness under assuming the potentials being L;g with certain correct numbers rj's. Notation. Let Q be a domain in Rd. Suppose P(x,D) = Z1a1-maa(x)Da is a differential operator of degree m with real functions aa (x) on Q. We denote by P = P(x,. + ik) the symbol of P(x, D) and by Npk) the zero set of P(x,. + ik) for any (x, k) E Q x Rd. Let's define a subset in Q x Sd-i: Ep = {(x,k) E Q x Sd-i: S d (x,I + ik) 1kcj 50 , detHesscP(x, ( + ik) =0 Vf E N,k)} where HesscP = (dL )is the complex Hessian matrix of P, and z = (+ik E Cd. If u is a function on Q, we define its normal support N(suppu) as a subset of Q x Sd-1. Say (x, k) E N(suppu) if there is a neighborhood V of x such that +b(y) < +(x) for all y E V n suppu and d+(x) = ?k, where b is some smooth function. Let s = 2(d+31) be the restriction number and s' be its conjugate number. We let Wim,2 be the Sobolev space of functions whose derivatives up to order m belong to L2. We have the following theorem. Theorem. Suppose P(x, D) is an elliptic differential operator with real Lipschitz functions a,), as coefficients on Q and is of order m < d. If a function u E WlmJ,2 (Q) satisfies (1) IPu(x)I S E VtI vm u Iu 0<,u<m
Aligning Mathematics Teacher Work Sample Content with Selected NCTM Standards: Implications for Preservice Teacher Education

Teacher Work Sample Methodology has been described as an alternative means/set of procedures for assessing teacher effectiveness in producing student learning that are more authentic than traditional means of teacher certification. To investigate the degree to which the methodology aligns with state/national standards, 50 work samples produced by student teachers at Western Oregon University between fall 1991 and spring 1999 were analyzed to determine: (1) the efficiency of Teacher Work Sample Methodology in moving state and national standards, for example, the NCTM standards, into the classroom; and (2) the extent to which Teacher Work Sample Methodology promotes alignment of standards, content, instruction and assessments of instruction. The research found that a majority of the student teacher work samples demonstrated weak alignment or no alignment between stated instructional objectives and selected NCTM Curriculum and Evaluation Standards (Problem Solving, Communication, Reasoning, and Connections). However, in most of the work samples, more than half of the pre/post-assessment methods (performance, knowledge) were aligned with the instructional objectives.
Mechanical Stress Regulation of Plant Growth and Development

The authors introduce the chapter with a discussion of lessons from nature, agriculture, and landscapes; terms and definitions; and an historical perspective of mechanical stress regulation of plant growth and development. Topics include developmental responses to mechanical stress; mechanical stress-environment interactions; metabolic, productivity, and compositional changes; hormonal involvement; mechanoperception and early transduction mechanisms; applications in agriculture; and research implications. The discussion of hormonal involvement in mechanical stress physiology includes ethylene, auxin, gibberellins, and other phytohormones. The discussion of applications in agriculture examines windbreaks, nursery practices, height control and conditioning, and enhancement of growth and productivity. Implications for research are related to handling plant materials, space biology, and future research needs.
Mik1: Mik1 protein kinase (S. pombe)

Mik1 was characterized via a genetic screen designed to identify mitotic inhibitors in the fission yeast, Schizosaccharomyce pombe(S. pombe). The mik1 gene complements the mitotic catastrophe defect in the double mutant strain, cdc2-3w wee1–50. It was sequenced and shown to be most homologous to the SpWee1 protein kinase that also complements cdc2-3w wee1–50. The mik1 gene disruption strain shows no apparent phenotype, but, the mik1::ura4 wee1–50 double mutant is inviable, suggesting that the two kinases have a redundant function in S. pombe: phosphorylation of the SpCdc2 protein kinase on Tyr15. The ATP-binding site is not completely conserved in Mik1. Instead of the GXGXXG motif, Mik1 has HXSXXS. However, mutation of the highly conserved lysine (K320A) results in a Mik1 that is unable to complement the mik1::ura wee1–50 double mutant. The wild-type mik1 and wee1 genes are able to complement the double mutant. Genetic analysis predicts that the substrate for Mik1 (and Wee1) is the Tyr15 residue of SpCdc2.
Gallium-67 scintigraphy of gynecologic tumors

Abstract This study of 24 gynecologic neoplasms was initiated with the hope that tumor localization of 67 Ga might prove to be clinically useful to: (1) serve as a screening device for the diagnosis of some primary gynecologic tumors or their recurrences; (2) demonstrate the presence of local or distant metastasis; and (3) facilitate clinical judgment regarding operability of certain lesions. At the present time, with the use of available techniques, our preliminary observations suggest that 67 Ga scintigraphy has not reliably delineated the distribution of the various gynecologic malignancies studies. Thus, 67 Ga does not appear to provide a satisfactory clinical method for determining the presence of metastasis or the operability of specific patients.
HOW AGING AFFECTS THE RELATIONSHIP BETWEEN THE DRIVER AND THE ROAD ENVIRONMENT

Description des effets de la baisse de l'acuite visuelle d'un conducteur sur ses capacites de perception de l'environnement routier
Long-Term Safety of Repeated Blood-Brain Barrier Opening via Focused Ultrasound with Microbubbles in Non-Human Primates Performing a Cognitive Task

Focused Ultrasound (FUS) coupled with intravenous administration of microbubbles (MB) is a non-invasive technique that has been shown to reliably open (increase the permeability of) the blood-brain barrier (BBB) in multiple in vivo models including non-human primates (NHP). This procedure has shown promise for clinical and basic science applications, yet the safety and potential neurological effects of long term application in NHP requires further investigation under parameters shown to be efficacious in that species (500kHz, 200–400 kPa, 4–5μm MB, 2 minute sonication). In this study, we repeatedly opened the BBB in the caudate and putamen regions of the basal ganglia of 4 NHP using FUS with systemicallyadministered MB over 4–20 months. We assessed the safety of the FUS with MB procedure using MRI to detect edema or hemorrhaging in the brain. Contrast enhanced T1-weighted MRI sequences showed a 98% success rate for openings in the targeted regions. T2weighted and SWI sequences indicated a lack edema in the majority of the cases. We investigated potential neurological effects of the FUS with MB procedure through quantitative cognitive testing of’ visual, cognitive, motivational, and motor function using a random dot motion task with reward magnitude bias presented on a touchpanel display. Reaction times during the task significantly increased on the day of the FUS with MB procedure. This increase returned to baseline within 4–5 days after the procedure. Visual motion discrimination thresholds were unaffected. Our results indicate FUS with MB can be a safe method for repeated opening of the BBB at the basal ganglia in NHP for up to 20 months without any long-term negative physiological or neurological effects with the parameters used.