cssi/SciSciGPT-SciSciNet huggingface dataset:
Is outpatient nesiritide safe for hypotensive heart failure patients

Background: Nesiritide (Nes) has been extensively studied for the treatment of decompensated heart failure within the hospital setting. Nes is indicated for use, and all Nes trials have enrolled patients with a baseline systolic blood pressure (SBP) 90 mm Hg. However, many patients treated and maintained on chronic oral heart failure medications consistently demonstrate SBP from 85-95 mm Hg. This study demonstrates the safety of Nes in patients with SBP 90 mmHg.Objective:Quantify the incidence of symptomatic hypotension in patients treated with Nes infusion in an outpatient heart failure clinic. Investigate any relationship between low baseline SBP or low SBP during Nes infusion and incidence of symptomatic hypotension. Observe the incidence of symptomatic hypotension when Nes is added as adjunctive therapy in patients with optimal use of oral betablockers, ACE inhibitors, and diuretic therapy. Methods: Retrospective chart review of 28 patients treated with Nes in the outpatient setting between April, 2002 and April, 2003 (all charts available for patients receiving Nes 2ug/kg bolus followed by 0.01ug/ kg/min for 4-6 hours). Total Nes infusion visits included in this analysis is 449, an average of 16 per patient. Symptoms were defined as complaint of light headedness or dizziness. Results: Average baseline SBP 109 37 mm Hg. 221/449 Nes visits (49%) demonstrated a SBP 90mmHgduringNes infusion therapy. Symptomatic hypotension occurredduring10/449visits (2.2%). 21/28 (75%)ofpatients exhibitedbaselineSBP 90 mm Hg (normotensive group) and 7/28 (25%) patients exhibited baseline SP 90 mm Hg (hypotensive group). Among the normotensive group 115/315 (37%) of Nes infusions were associated with SBP 90mm Hg and 5/315 (1.6%) of patients demonstrated symptomatic hypotension. Among the hypotensive group 106/134 (79%) of visits demonstratedSP 90mmHgand5/134 (3.7%)demonstrated symptomatichypotension.Among the 10/449 visits demonstrating symptomatic hypotension, 9 resolved simply with An Embolic Event Contributes to Death in 2/3 of Patients with Idiopathic Dilated Cardiomyopathy in End Stage Heart Failure Antonio C.P. Barretto, Mucio T. Oliveira, Jr. Robinson T. Munhoz, Airton R. Scipioni, Maria L. Higuchi, Jose A.F. Ramires1—Prevention and Rehabilitation Cardiovascular Service, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil
Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets

Background As large genomics and phenotypic datasets are becoming more common, it is increasingly difficult for most researchers to access, manage, and analyze them. One possible approach is to provide the research community with several petabyte-scale cloudbased computing platforms containing these data, along with tools and resources to analyze it. Methods Bionimbus is an open source cloudcomputing platform that is based primarily upon OpenStack, which manages on-demand virtual machines that provide the required computational resources, and GlusterFS, which is a high-performance clustered file system. Bionimbus also includes Tukey, which is a portal, and associated middleware that provides a single entry point and a single sign on for the various Bionimbus resources; and Yates, which automates the installation, configuration, and maintenance of the software infrastructure required. Results Bionimbus is used by a variety of projects to process genomics and phenotypic data. For example, it is used by an acute myeloid leukemia resequencing project at the University of Chicago. The project requires several computational pipelines, including pipelines for quality control, alignment, variant calling, and annotation. For each sample, the alignment step requires eight CPUs for about 12 h. BAM file sizes ranged from 5 GB to 10 GB for each sample. Conclusions Most members of the research community have difficulty downloading large genomics datasets and obtaining sufficient storage and computer resources to manage and analyze the data. Cloud computing platforms, such as Bionimbus, with data commons that contain large genomics datasets, are one choice for broadening access to research data in genomics.
UV light-induced changes to the surface conduction in hydrothermal ZnO

High quality, bulk ZnO crystals grown by Tokyo Denpa using the hydrothermal process typically exhibit a room temperature carrier concentration in the 1013–1014 cm−3 range and a low mobility, conductive surface layer, observed at low temperature, with a sheet concentration on the order of 1012–1013 cm−2. In the sample discussed here, bulk conduction is controlled by two donor levels at 50 and 400 meV with concentrations of 1.2×1016 and 1.5×1016 cm−3, respectively. Temperature-dependent photo-Hall-effect measurements, using blue/UV light, in vacuum show an increase in the surface sheet carrier density to more than 1×1013 cm−2 at low to intermediate temperatures while the two bulk donors continue to dominate the high temperature behavior, up to 400 K. Long-lived persistent photoconductivity (PPC) is observed when the sample is returned to the dark. When the PPC is allowed to fully relax and the sample is exposed to air, there is surprisingly no longer any surface conduction at low temperature, while the two ...
Circumstellar aluminum oxide and silicon carbide in interplanetary dust particles

Abstract A systematic NanoSIMS isotope imaging study of sub-micrometer phases in interplanetary dust particles (IDPs) has led to the discovery of two presolar grain types that previously were observed only in primitive meteorites. A 350 × 600 nm 2 Al 2 O 3 grain has a large 17 O enrichment and a slight 18 O depletion, as well as a 26 Mg excess due to the decay of extinct 26 Al. Because of its relatively large size and prominent location within the IDP, this presolar Al 2 O 3 grain is well characterized by SEM-EDX analyses. A second, much smaller presolar grain has a diameter of 150 nm and a 13 C enrichment of more than 300%. Isotopic anomalies in C are rarely found in IDPs and the magnitude of this anomaly is unprecedented. This grain also has a 15 N-rich composition and its isotopic makeup as well as its secondary ion yields identify it as a SiC grain. The discovery of presolar Al 2 O 3 and SiC in IDPs seamlessly complements earlier notions of interplanetary dust particles as the most primitive extraterrestrial material currently available for laboratory analysis. Both Al 2 O 3 and SiC are common presolar grain types in primitive meteorites, but they appeared conspicuously absent from the presolar grain inventory in interplanetary dust particles, which is dominated by silicate stardust. Not finding these presolar grain types in interplanetary dust would have been difficult to explain. Abundance estimates of the new presolar grain types in IDPs are hampered by limited statistics, but both Al 2 O 3 and SiC are less common than presolar silicates which have been found at relatively high abundances in IDPs. The particle in which these presolar grains have been found belongs to the ‘isotopically primitive subgroup’ of IDPs, yet does not contain any presolar silicates.
Epa's Basins Model: Good Science or Serendipitous Modeling?

: Better Assessment Science Integrating Point and Non-point Sources (BASINS) is a geographic-based watershed assessment tool developed by EPA's Office of Water to help states more efficiently target and evaluate water-bodies that are not meeting water quality standards. BASINS (EPA, 1996a, 1998) brings together data on water quality and quantity, land uses, point source loadings, and other related spatial data with supporting nonpoint and water quality models at a quicker and more effective pace. EPA developed BASINS, to better integrate point and nonpoint source water quality assessments for the Nation's 2100+ watersheds. In its zeal to achieve this endpoint, EPA has initiated a simplistic approach that was expected to grow through scientific enhancements as TMDL developers become more familiar with modeling requirements. BASINS builds upon federal databases of water quality conditions and point source loadings for numerous parameters where quality assurance is suspect in some cases. Its design allows comprehensive assessments and modeling in typical Total Maximum Daily Load (TMDL) computations. While the TMDL utility is the primary reason BASINS was developed, other longer-range water quality assessments will become possible as the Agency expands the suite of assessment models and databases in future releases. The simplistic approach to modeling and user-friendly tools gives rise, however, to technical and philosophical concerns related to default data usage. Seamless generation of model input files and the failure of some utilities to work properly suggest to NCASI that serious problems may still exist and prompts the need for a more rigorous peer-review. Furthermore, sustainable training becomes paramount, as some older modelers will be unfamiliar with Geographic Information System (GIS) technology and associated computer skills. Overall, however, BASINS was judged to be an excellent beginning tool to meet the complex environmental modeling needs in the 21st Century.
Neuroendocrine-Immune Interactions in Neurotropic Viral Infections

The nervous system, endocrine system, and immune system are highly connected and affect the outcome of viral infections. This chapter introduces a brief history of the field of psychoneuroimmunology and then provides examples of the impact of stress on two neurotropic viral infections: herpes simplex and Theiler’s virus.
COSTIMULATORY RECEPTORS FOR THE SUPERANTIGEN STAPHYLOCOCCAL ENTEROTOXIN B ON HUMAN VASCULAR ENDOTHELIAL CELLS AND T CELLS

Cell-surface molecules on human vascular en- dothelial cells (ECs) and T lymphocytes that mediate staphylococcal enterotoxin B (SEB)-induced T cell proliferation and cytokine production were investigated. Expression of HLA-DR and intercellular adhesion molecule 1 (ICAM-1) on EC was induced by interferon-'y (IFN-y). IFN-�y-treated ECs bound SEB effectively and stimulated T cells to proliferate and secrete tumor necro- sis factor a (TNF-a) and IFN--y. SEB-induced T cell proliferation was inhibited by monoclonal antibodies to CD2, CD11a, CD28, ICAM-1, and endothelial leukocyte adhesion molecule (ELAM). These antibodies also blocked production of the proinflammatory mediators, TNF-a and IFN-y, in SEB-stimulated T cell-EC cocul- tures. These results suggest that the surface molecules, CD11a:CD18/ICAM-1, CD2, CD28, and ELAM, are all important costimulatory receptors for T cell activation by superantigens with the EC as the antigen-presenting cell. Thus, like conventional antigens, multiple stimulatory signals from the interactions of these receptors are re- quired for superantigen-induced immune responses with ECs and T cells. Reducing proinfiammatory mediators such as TNF-a and IFN-y by these antibodies in SEB- induced T cell responses may be a useful therapeutic strategy for circumventing SEB toxicity and pathogene- sis. J- Leukoc. Biol. 56: 458-463; 1994. In this study, the superantigen SEB was used to activate T cells to examine the role of costimulatory molecules in T cell activation using IFN-"y-treated ECs as antigen- presenting cells (APCs). The induction by SEB of the proinflammatory mediators TNF-a and IFN-'y in the super- natants of T cell-EC cocultures was also investigated. The results indicate that IFN--y-treated ECs can serve as APCs and can provide other costimulatory signals to support a T cell-mediated response to SEB. Furthermore, monoclonal antibodies (mAbs) reacting with CD2, CD11a/intercellular adhesion molecule 1 (ICAM-1), CD28, and endothelial leu- kocyte adhesion molecule (ELAM) were found to inhibit T cell proliferation and cytokine production.
Characterization of potential interactions between transferrin binding proteins in Neisseria gonorrhoeae

S AND PRESENTATIONS Shreni Mistry and Cynthia Nau Cornelissen. 2012. Characterization of potential interactions between transferrin binding proteins in Neisseria gonorrhoeae. 18 th International Pathogenic Neisseria Conference (IPNC), Wurzburg, Germany
Multi-vehicle path planning for non-line of sight communication

This paper presents the formulation and hardware results of a mixed-integer linear programming approach to online connectivity-constrained trajectory planning of autonomous helicopters through cluttered environments. A lead vehicle must execute a certain mission whereby wireless line of sight communication to its ground station is lost. Relay helicopters are therefore introduced that must position themselves in such a way that indirect line of sight connectivity between the leader and the ground station is always maintained. The corresponding coordinated multi-vehicle trajectory optimization is tackled using both centralized and distributed receding horizon planning strategies. Binary variables are used to capture connectivity, obstacle- and collision avoidance constraints, extending earlier formulations to model nonconvex obstacles more efficiently. Simulation, hardware in the loop, and flight test results are presented for a centralized two-helicopter mission. Simulation results for a distributed scenario are given as well.
Origin of Dolomite Cement in Chesapeake Group (Miocene) Siliciclastic Sediments: An Alternative Model to Burial Dolomitization

ABSTRACT Ferroan dolomite and calcite cement fossiliferous sandstone unite in the Choptank and Calvert Formations (Miocene) of western Maryland and northern Virginia. The average composition of the dolomite is Ca.55Mg.43Fe.02CO3, though nonferroan dolomite is also present. The dolomite is generally euhedral and zoned, and it may have fluid-inclusion-rich cores. Calcite cements are dominantly composed of equant spar, though a fine, acicular, isopachous rim cement may be present. Calvert Formation dolomite is chemically similar to Choptank Formation dolomite, though the former contains both calcite inclusions and hollow centers. A relatively simple burial history for ferroan dolomite and calcite cement, coupled with petrographic and isotopic evidence, indicates that some of the dolomite has a marine origin, possibly under the influence of sulfate-reducing organisms. Later recrystallization may have occurred under the influence of alternating marine and meteoric-phreatic conditions. Zoned dolomite rhombs, dolomite with calcite cores, and clear dolomite rims indicate episodic crystallization, possibly due to multiple periods of phreatic conditions. Most of the calcite cement is demonstrably meteoric in origin. Dolomite cement is generally confined to permeable sandy intervals bounded on the top and bottom by clays of low permeability. When buried, this sequence would be similar to dolomite sequences inferred to be of deep burial in origin. The timing of dolomite formation in Chesapeake Bay sediments is significant in that most of the dolomite has derived its magnesium from sources other than the clays, as has been suggested in deep-burial dolomitization models.
Hybrid physical–chemical vapor deposition of Bi2Se3 films

Abstract Bi2Se3 thin films were grown on c-plane sapphire substrates by hybrid physical-chemical vapor deposition (HPCVD) using trimethyl bismuth (TMBi) and Se pellets. A Se-rich environment is created by evaporating Se pellets in the vicinity of the substrate, which is used to suppress the formation of Se vacancies. The effects of pre-cracking temperature and substrate/Se temperature on the growth rate, structural and electrical properties of the Bi2Se3 films were investigated. C-axis oriented films were obtained which show a reduction in the carrier concentration as pre-cracking temperature was increased from 290 °C (1.6×1019 cm−3) to 350 °C (8.4×1018 cm−3). An additional reduction in carrier concentration (7.28×1018 cm−3) was observed on increasing the substrate temperature from 200 to 260 °C.
Solving multiple isolated, interleaved, and blended tasks through modular neuroevolution

Many challenging sequential decision-making problems require agents to master multiple tasks. For instance, game agents may need to gather resources, attack opponents, and defend against attacks. Learning algorithms can thus benefit from having separate policies for these tasks, and from knowing when each one is appropriate. How well this approach works depends on how tightly coupled the tasks are. Three cases are identified: Isolated tasks have distinct semantics and do not interact, interleaved tasks have distinct semantics but do interact, and blended tasks have regions where semantics from multiple tasks overlap. Learning across multiple tasks is studied in this article with Modular Multiobjective NEAT, a neuroevolution framework applied to three variants of the challenging Ms. Pac-Man video game. In the standard blended version of the game, a surprising, highly effective machine-discovered task division surpasses human-specified divisions, achieving the best scores to date in this game. In isolated and interleaved versions of the game, human-specified task divisions are also successful, though the best scores are surprisingly still achieved by machine discovery. Modular neuroevolution is thus shown to be capable of finding useful, unexpected task divisions better than those apparent to a human designer.
A Comparative Study of Heated Single and Equivalent Twin Jets

This paper compares the flow characteristics and noise generated by a single axisymmetric nozzle and parallel and canted twin nozzle configurations. The twin nozzles were designed such that they had a cumulative exit area equivalent to that of the single nozzle. PIV images obtained for the jets operating at cold conditions reveal that the parallel jets begin to merge at x/D = 4 (D = single nozzle diameter) while the canted jets begin to merge at x/D = 2. Of note is that for x/D > 12, the merged canted jets appear to have a jet width that is similar to that of the single jet. Acoustic measurements were made using heated jets operating at comparable conditions. As expected, the parallel twin nozzles produced less noise, up to 3 dB, than the single nozzle at all of the angles examined here. Canting the twin nozzles together reduced the noise suppression benefits and the resulting jet noise was similar to that of the single jet at some angles, depending upon the twin jet orientation. A dependence on the orientation of the jets was also exhibited by the frequency spectra for both the parallel and canted twin jets in both the peak radiation and normal directions. The eect of water microjet injection on the twin jet configurations is also discussed and reductions of up to 7 dB have been observed.
Towards High Pulse Energy and Short Pulse Duration Fiber Laser Oscillators

Recent progress in all-normal dispersion fiber laser design indicates these sources will be capable of producing intense ultrashort pulses. Experimental delivery of 10’s of nanoJoules compressed to sub-45 fs pulse duration will be presented.
Expressions and clinical significance of Tiam1 and Rac1 in human colorectal cancer

OBJECTIVE:To investigate the expressions and clinical significance of T lymphoma invasion and metastasis inducing factor 1(Tiam1) and Rac GTPase activating protein 1(Rac1)in human colorectal cancer (CRC) and normal colorectal mucosa. METHODS: The expressions of Tiam1 and Rac1 proteins in formalin-fixed, paraffin-embedded specimens of colorectal cancer and normal colorectal mucosa of 50 cases respectively were detected by using SP immunohistochemical method. Simultaneously its relationship to the clinicopathological parameters of colorectal cancer was analysed. RESULTS: There was negative staining of Tiam1 and Rac1 proteins in normal colorectal mucosa (0/50, 0%), while positive staining was detected in colorectal cancer (42/50, 84.00% ).There were significant differences between them(P=0.003). Accompanyed with differentiated degree of histologic type descending, depth of invasion increasing, stage of TNM upgrading and lymph node metastasis happening, the positive staining rates of Tiam1 and Rac1 proteins in colorectal cancer significantly ascended (P=0.025,0.01,0.01,0.007,respectively), but there was no obvious correlation between its expression and the sex, age of patient, primary pathological location or size of colorectal cancer (P=0.686, 0.975, 0.791, 0.709, respectively). CONCLUSION: The expressions of Tiam1 and Rac1 proteins in human colorectal cancer are obviously correlated with the clinical stage, the degree of differentiation and tumor metastasis.
The clinical value of antithrombin-III, D-dimer and platelet in children with sepsis

Objectives To study the clinical value of antithrombin-III(AT-III),D-dimer(DD) and platelet(PLT) in children with sepsis.Methods One hundred and three children in pediatric intensive care unit were divided into ordinary infection group(n=30) and sepsis group(n=73),and 30 healthy children were selected as control group.Plasma AT-III activity,DD level and PLT count were detected.Results Compared with control group and ordinary infection group,AT-III activity and PLT count were both significantly lower(P0.01) and DD level was significantly higher(P0.01) in sepsis group.The differences of the three parameters were not significant between control group and ordinary infection group.However,AT-III activity and PLT count were both significantly lower(P0.05) and DD level was significantly higher(P0.01) in severe sepsis group,disseminated intravascular coagulation(DIC) group and death group.The abnormal rate of all the three parameters was 70.37% in DIC group.Conclusions Children with sepsis have obvious dysfunction of coagulation and fibrinolysis system.The activity of AT-III,DD level and PLT count are helpful for the early diagnosis of DIC in children with sepsis,and can also be valuable in the evaluation of severity and prognosis.
Termination in the Dora case.

Freud's insistence on interpreting Dora's second dream after she had announced that this would be her last analytic session illustrates his preoccupation with dreams as well as his failure to understand what Dora wanted from the analysis. Freud remained concerned with the relationship between Dora's symptoms (dreams) and her psychic reality; she was more interested in the external realities of her life, e.g., leaving analysis. Although the theme of termination was noted in Freud's interpretation of Dora's first dream, it was neglected during the final two weeks of the analysis. Freud's interpretations of Dora's dreams became the subject of the analysis, and Dora felt excluded. Several aspects of Freud's negative countertransference have been noted above: the analytic situation in many ways paralleled Dora's relationship with her mother; negative maternal elements in the transference destroyed any hopes Dora might have had of finding a suitable parent in Freud. The analysis ended with both Freud and Dora feeling betrayed.
A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors.

Human macrophage migration inhibitory factor (MIF) is both a keto–enol tautomerase and a cytokine associated with numerous inflammatory diseases and cancer. Consistent with observed correlations between inhibition of the enzymatic and biological activities, discovery of MIF inhibitors has focused on monitoring the tautomerase activity using l-dopachrome methyl ester or 4-hydroxyphenyl pyruvic acid as substrates. The accuracy of these assays is compromised by several issues including substrate instability, spectral interference, and short linear periods for product formation. In this work, we report the syntheses of fluorescently labeled MIF inhibitors and their use in the first fluorescence polarization-based assay to measure the direct binding of inhibitors to the active site. The assay allows the accurate and efficient identification of competitive, noncompetitive, and covalent inhibitors of MIF in a manner that can be scaled for high-throughput screening. The results for 22 compounds show that the most...
Quasicoherent double-resonance fluorescence correlation: a selective method for studying molecular and particulate motion in complex systems

Quasielastic light scattering (QLS) is a powerful technique for studying the fluctuations of molecular and particulate systems. Its use in complex systems such as intact living cells is limited by the predominance of scattering from large structures other than the components being studied. We propose and analyze a novel method analogous to QLS but selective for molecules or particles bearing a particular labeling chromophore, using correlation spectroscopy of a quasicoherent component of double-resonance fluorescence (QDORF).
Biological Time Measurement

Man is clearly able to sense time, sometimes quite accurately. For example, most of us are able to wake up at the same time of day with a little practice. One wonders whether plants and other animals also have the ability to measure time. Regular patterns of migration or flowering might lead one to suspect that this is the case (daylength could be measured to detect season), but on the other hand, occurrences that take place at a given time of year might be responses to changes in temperature or some other climatic factor.
Free Trade Among the Industrialised Nations

The main theme of this book is that there exist sets of conditions under which some departure from free trade may be warranted. The three major reasons for invoking some sort of discrimination against foreign goods are that: (a) a nation’s economy may suffer a temporary loss of competitiveness because of transitory disturbances (frequently in the financial sector). Or an important industry may temporarily lose its international competitiveness but this competitiveness may be regained (to a substantial degree at least) by improving the industry’s domestic efficiency. This will take time and conditional protection is warranted to allow the temporary conditions to evanesce or to allow the needed improvement in domestic efficiency to be achieved (b) the speed of adjustment imposed by the free action of market forces could be excessive and inflict unnecessarily high social costs. Under such conditions protection is warranted to slow down (but not to stop) the process of adjustment (c) the combination of new labour-saving technologies (chips and robots), together with the enhanced ability of labour-surplus nations to supply manufactured goods which meet the quality requirements of the industrialised world, will create chronic unemployment for low-skilled workers
Capacity of block Rayleigh fading channels without CSI

A system with a single antenna at the transmitter and receiver and no channel state information at either is considered. The channel experiences block Rayleigh fading with a coherence time of T 0 symbol times and the fading statistics are assumed to be known perfectly. The system operates with a finite average transmit power. It is shown that the capacity optimal input distribution in the T 0 -dimensional space is the product of the distribution of an isotropically-distributed unit vector and a distribution on the 2-norm in the T 0 -dimensional space which is discrete and has a finite number of points in the support. Numerical evaluations of this distribution and the associated capacity for a channel with fading and Gaussian noise for a coherence time T 0 = 2 are presented for representative SNRs. It is also shown numerically that an implicit channel estimation is done by the capacity-achieving scheme.
Plasma NGAL: So, it Really Is Just Expensive Creatinine!

Worsening renal function (WRF), commonly observed during the treatment of patients with acute decompensated heart failure (ADHF), is associated with increased mortality, recurrent heart failure (HF) hospitalizations and frequently limits the institution and up-titration of clinically indicated
Dysplasia, Malformations and Cancer, Especially with Respect to the Wiedemann-Beckwith Syndrome

Changes in the cellular composition of our organs and tissues are occurring continuously from conception till death. If these changes lead to the appearance of structurally and/or functionally abnormal cells, either by change of a local cell type, or through immigration of cells foreign to the tissue or organ, or to physiological or microscopic evidence of progressive cellular malfunction or death, then they are frequently called degeneration by pathologists. These changes may be “normal” or abnormal, transient, relapsing or permanent. The most common “normal” prenatal degenerative changes are all of the genetically programmed types of cell death which occur at fixed times during organogenesis and which, for example, are responsible for our lack of a tail, the absence of webbing between our digits, the fact that we have separate urethral and anal outlets, the absence of heterosexual internal genitalia and so forth. Normal postnatal degenerative changes include all the “normal” cellular changes of aging, including the lamentable but apparently relentless loss of CNS ganglion cells, the atresia of millions of primary oocytes during the first few decades of a woman’s life, etc.
Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department

Background Only a small fraction of acute chest pain in the emergency department (ED) is due to obstructive coronary artery disease (CAD). ED chest pain remains associated with high rates of recidivism, often in the presence of nonobstructive CAD. Psychological states such as depression, anxiety, and elevation of perceived stress may account for this finding. The objective of the study was to determine whether psychological states predict recurrent chest pain (RCP). Methods We conducted a prospective cohort study of low– to moderate–cardiac risk ED patients admitted to the Yale Chest Pain Center with acute chest pain. Depression, anxiety, and perceived stress were assessed in each patient using multistudy-validated screening scales: Patient Health Questionnaire (PHQ8), Clinical Anxiety Scale (CAS), and Perceived Stress Scale (PSS), respectively. All patients ruled out for infarction underwent appropriate cardiac stress testing. Primary outcome was RCP at 30 days evaluated by phone follow-up and medical record. The relationship between each psychological scale and RCP was evaluated using ordinal logistic regressions, controlling for known sociodemographic and cardiac risk factors. Depression (PHQ8 ≥ 10), anxiety (CAS ≥ 30), and perceived stress (PSS ≥ 15) were considered positive. Results Between August 2013 and May 2015, 985 patients were screened at the Yale Chest Pain Center. Of 500 enrolled patients, 483 patients had complete data and 365 (76%) patients completed follow-up. Thirty-six percent (n = 131) had RCP within 1 month. On multivariable regression models, depression (odds ratio [OR] = 2.11, 95% CI 1.18-3.79) was a significant independent predictor of 30-day chest pain recurrence after adjustment, whereas PSS (OR = 0.96, 95% CI 0.60-1.53) and anxiety (OR = 1.59, 95% CI 0.80-3.20) were not. Similarly, there was a direct relationship between psychometric evaluation of depression (via PHQ8) and the frequency of chest pain. Conclusions Depression is independently associated with RCP regardless of significant cardiac ischemia on stress testing. Identification and targeted interventions may curtail recidivism with RCP.
Menegaskan Kembali Komitmen Negara Hukum: Sebuah Catatan Atas Kecenderungan Defisit Negara Hukum di Indonesia

Bila dilacak akarnya, gagasan tentang negara hukum, adalah kelanjutan dari pemikiran tentang pembatasan kekuasaan, sebagai sealah satu prinsip dari konstitusionalisme-demokrasi. Inti dari pemikiran tentang negara hukum, adalah adanya pembatasan terhadap kekuasaan, melalui sebuah aturan yuridis—undang- undang. Seperti diungkapkan Andrew Heywood, menurutnya dalam ruang lingkup yang sempit, konstitusionalisme dapat ditafsirkan sebatas penyelenggaraan negara yang dibatasi oleh undang-undang dasar—inti negara hukum. Artinya, suatu negara dapat dikatakan menganut paham konstitusionalisme jikalau lembaga-lembaga negara dan proses politik dalam negara tersebut secara efektif dibatasasi oleh konstitusi. Sedangkan dalam pengertian yang luas, konstitusionalisme adalah perangkat nilai dan manifestasi dari aspirasi politik warganegara, yang merupakan cerminan dari keinginan untuk melindungi kebebasan, melalui sebuah mekanisme pengawasan, baik internal maupun eksternal terhadap kekuasaan pemerintahan (Heywood, 2002: 297). ...
RotorNet: A Scalable, Low-complexity, Optical Datacenter Network

The ever-increasing bandwidth requirements of modern datacenters have led researchers to propose networks based upon optical circuit switches, but these proposals face significant deployment challenges. In particular, previous proposals dynamically configure circuit switches in response to changes in workload, requiring network-wide demand estimation, centralized circuit assignment, and tight time synchronization between various network elements--- resulting in a complex and unwieldy control plane. Moreover, limitations in the technologies underlying the individual circuit switches restrict both the rate at which they can be reconfigured and the scale of the network that can be constructed.We propose RotorNet, a circuit-based network design that addresses these two challenges. While RotorNet dynamically reconfigures its constituent circuit switches, it decouples switch configuration from traffic patterns, obviating the need for demand collection and admitting a fully decentralized control plane. At the physical layer, RotorNet relaxes the requirements on the underlying circuit switches---in particular by not requiring individual switches to implement a full crossbar---enabling them to scale to 1000s of ports. We show that RotorNet outperforms comparably priced Fat Tree topologies under a variety of workload conditions, including traces taken from two commercial datacenters. We also demonstrate a small-scale RotorNet operating in practice on an eight-node testbed.
CENTENARIO DE DARWIN

Apoyado en numerosos cientificos que combaten la hipotesis evolucionista, el autor muestra que esta carece de todo fundamento empirico. Es mas, et verdadero autor de tal teora fue Herbert Spencer. Conocida esta por Darwin, y rechazada por no ser cientifica, reconoce que nada tiene que ver con su doctrina: esta puede definirse como la de la seleccion natural o la de la descendencia con modificacion. Mediante estos mecanismos, Darwin supone, siguiendo la hipotesis economica liberal, que se explica toda la inmensa variedad de especies que hoy pueblan el planeta. No solo biologos y paleontologos la combaten, sino que fisicos y matematicos han mostrado su imposibilidad
Toward Rational Design of Cu/SSZ-13 Selective Catalytic Reduction Catalysts: Implications from Atomic-Level Understanding of Hydrothermal Stability

The hydrothermal stability of Cu/SSZ-13 SCR catalysts has been extensively studied, yet atomic-level understanding of changes to the zeolite support and the Cu active sites during hydrothermal aging are still lacking. In this work, via the utilization of spectroscopic methods including solid-state 27Al and 29Si NMR, EPR, DRIFTS, and XPS, together with imaging and elemental mapping using STEM, detailed kinetic analyses, and theoretical calculations with DFT, various Cu species, including two types of isolated active sites and CuOx clusters, were precisely quantified for samples hydrothermally aged under varying conditions. This quantification convincingly confirms the exceptional hydrothermal stability of isolated Cu2+-2Z sites and the gradual conversion of [Cu(OH)]+-Z to CuOx clusters with increasing aging severity. This stability difference is rationalized from the hydrolysis activation barrier difference between the two isolated sites via DFT. Discussions are provided on the nature of the CuOx clusters ...
Epithelioid Angiosarcoma of the Thyroid Associated with Multinodular Goiter, Graves Disease, and Papillary Thyroid Carcinoma

ABSTRACT Objective: We describe an interesting case of primary thyroid epithelioid angiosarcoma associated with both Graves disease and multinodular goiter, presenting as thyrotoxicosis and enlarging neck mass. Methods: Chart review for this single case was approved by the Institutional Review Board and patient consent was obtained. Results: A 61-year-old female with longstanding history of multinodular goiter presented with rapidly enlarging neck girth and symptoms of thyrotoxicosis. Thyroid function testing revealed suppressed thyroid-stimulating hormone (TSH) of <0.005 μIU/mL, an elevated free thyroxine of 3.0 ng/dL (normal range, 0.7 to 1.8 ng/dL), and free triiodothyronine of 5.9 pg/mL (normal range, 1.8 to 4.6 pg/mL). TSH receptor antibodies were significantly elevated. Iodine-123 uptake and scan demonstrated elevated 4- and 24-hour uptake with heterogeneous bilateral distribution, exhibiting background diffuse uptake with a left inferior lobe hypofunctioning nodule, and signal attenuation in the ri...
Long-term CT surveillance after primary lung cancer treatment captures events in all risk groups.

In the article “ Risk Stratification for Second Primary Lung Cancer ” by Han et al . (1), the authors address the problem of selective screening of lung cancer survivors by creating a competing-risk prognostic model to determine the probability of a secondary primary lung cancer (SPLC).
An Analysis of the Liberal Arts in Introductory Meteorology Courses

A questionnaire was designed to probe the degree to which specific pedagogical tasks or techniques are incorporated into introductory meteorology courses. Responses from higher education institutio...
Lanthanide-Labeled DNA

Lanthanides, as alternative probes to conventional fluorophores, can lead to enhanced sensitivity in applications where autofluorescence is a problem. Multiple labeling with lanthanide chelates have been shown to be an effective method for further increases in sensitivity. These probes, being nonisotopic, avoid the many practical problems associated with radioactive probes. Lanthanide probes are particularly advantageous in resonance energy transfer, whether for measuring distances in biocomplexes or when used to generate new lifetime tailored dyes.
Cognition, Emotion, and Illness

Whenever general physicians are polled as to the source of their patients’ complaints, they invariably respond that most symptoms are directly or indirectly related to emotional factors (Shapiro, 1959). However, excluding a vigorous neurohumoral and behavioural tradition in animal research, there is surprisingly little scientific work elucidating the role of human emotion in illness. Even among researchers, the study of emotions has in many ways remained in the domains of subjective conjecture, patient anecdotes, and armchair psychology.
Interacting Effects of Leg Autotomy and Exposure to Predator Cues on Survival in A Wolf Spider (Pardosa valens)

Chemical cues from predators (kairomones) are used by many aquatic and terrestrial animals when deciding on behavioral responses to predation threats. These responses may also be affected by the animal’s physiological state (e.g., nutrition level, parasitism, or prior injury), which could alter normal responses to kairomones. In this study, we examined effects of leg autotomy (the voluntary sacrifice of a leg) on subsequent responses to predator chemical cues in females of the riparian-zone wolf spider Pardosa valens. In a fully-crossed design, spiders with all legs intact or with one leg removed were exposed to one of two cue treatments for 90 min: a control (no predator cue) or one with chemical cues (silk and excreta) from a larger sympatric wolf spider, Rabidosa santrita. We then introduced an R. santrita into each container, and recorded subsequent survival of P. valens. Survivorship was significantly higher for individuals previously exposed to predator cues than for those in the control group; however, autotomy had no effect on survivorship, which was similar for both intact and autotomized spiders in both the predator-cue and control treatments. In addition, although P. valens were more likely to be found off the substrate than on it when the predator was added in each of the four treatment pairings, this initial position did not influence survivorship. These results therefore indicate that P. valens can behaviorally respond to predator kairomones in ways that reduce their risk of predation, but that this response is unaffected by the prior sacrifice of a leg.
Provoked poachers? Applying a situational precipitator framework to examine the nexus between human-wildlife conflict, retaliatory killings, and poaching

The poaching of wildlife has received substantial interest from criminologists in recent years. In particular, prior research has attempted to better understand the factors that drive individuals t...
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.

Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles in carcinogenesis remain only partially elucidated. Because the nuclear factor erythroid2-related factor2 (NRF2) signaling pathway is involved in human cancers, we hypothesize that genetic variants in NRF2 pathway genes are associated with PanC risk. To test this hypothesis, we assessed associations between 31 583 common single nucleotide polymorphisms (SNP) in 164 NRF2-related genes and PanC risk using three published genome-wide association study (GWAS) datasets, which included 8474 cases and 6944 controls of European descent. We also carried out expression quantitative trait loci (eQTL) analysis to assess the genotype-phenotype correlation of the identified significant SNP using publicly available data in the 1000 Genomes Project. We found that three novel SNP (ie, rs3124761, rs17458086 and rs1630747) were significantly associated with PanC risk (P = 5.17 × 10-7 , 5.61 × 10-4 and 5.52 × 10-4 , respectively). Combined analysis using the number of unfavorable genotypes (NUG) of these three SNP suggested that carriers of two to three NUG had an increased risk of PanC (P < 0.0001), compared with those carrying zero to one NUG. Furthermore, eQTL analysis showed that both rs3124761 T and rs17458086 C alleles were associated with increased mRNA expression levels of SLC2A6 and SLC2A13, respectively (P < 0.05). In conclusion, genetic variants in NRF2 pathway genes could play a role in susceptibility to PanC, and further functional exploration of the underlying molecular mechanisms is warranted.
Understanding new metaphors

Metaphors are widespread in natural language. Most natural language processing systems have failed to adequately deal with this issue. A two part approach to this problem involving a Metaphoric Lexicon and a dynamic extension system is described. The extension mechanism operates by analogically mapping previously understood mappings to account for new uses based on known regularities in the English metaphor system. A system based on this approach has been applied to the UNIX domain. Results indicate that this domain exhibits all the predicted regularities and that understanding new senses is possible using these regularities
Abstract 113: Chemerin Regulates Adipocyte Size in Mesenteric Perivascular Adipose Tissue When on a Normal but Not High Fat Isocaloric Diet

Chemerin is an adipokine, positively associated with blood pressure, and used as a marker for metabolic syndrome. We hypothesized that a global knockout (KO) of chemerin in the rat would lead to a ...
Everyday Racial Discrimination and Hypertension among Midlife African American Women: Disentangling the Role of Active Coping Dispositions versus Active Coping Behaviors.

Racial discrimination, a psychosocial stressor, may contribute to disproportionate rates of hypertension among African American women. Coping moderates the effects of psychosocial stress on health. Coping dispositions describe stable personality characteristics, whereas contextual frameworks emphasize flexible coping behaviors in response to specific stressful encounters. Using data from the African American Women’s Heart and Health Study—a non-probability cross-section of 208 midlife African American women in Northern California—we estimated the association between everyday racial discrimination (Everyday Discrimination Scale, EDS) and prevalence of hypertension (HTN), and evaluated moderation by coping disposition (John Henryism Active Coping scale, JH) versus context-specific active coping behavior (Active Coping with Racism scale, ACR). There were no main associations between EDS, JH, or ACR on HTN prevalence. There was evidence of statistical interaction between EDS and ACR (p-int = 0.05), but not JH (p-int = 0.90). Among those with high levels of ACR, reporting monthly (prevalence ratio (PR) = 2.35, 95% confidence interval (CI) = 1.13, 4.87), weekly (PR = 2.15, 95% CI = 1.01, 4.61), or daily (PR = 2.36, 95% CI = 1.14, 4.88) EDS was associated with higher HTN prevalence, versus reporting racial discrimination yearly or less. In contrast, among those with low levels of ACR, reporting more chronic racial discrimination was associated with lower hypertension prevalence, although results were less precise. Findings suggest that ongoing active coping with chronic racial discrimination may contribute to hypertension risk among African American women.
MRI-guided pelvic lymph node biopsy via transrectal approach in prostate cancer.

Abstract Lymph node assessment in prostate cancer is most commonly performed at the time of radical prostatectomy. We present the case of pre-operative pelvic lymph node sampling with the use of MRI/TRUS fusion-guided biopsy at the time of prostate biopsy. Lymph node pathology revealed metastatic, poorly differentiated prostate cancer, concurrent with Gleason 4 + 5 disease showing perineural invasion. The use of MRI fusion guided biopsy for nodal sampling may be an effective method pre-operative staging and treatment planning for prostate adenocarcinoma.
Convergent Validity of the Patient Reported Outcomes Measurement Information System's (PROMIS) Physical Function Computerized Adaptive Test (PF-CAT) for the Knee and Shoulder Injury Sports Medicine Patient Population

Purpose To evaluate the convergent validity, precision, and completion times for the Physical Function Computerized Adaptive Test (PF-CAT) in a sports medicine patient population relative to standard measures of knee and shoulder function. Methods We reviewed all patient visits from April through September 2014 with either knee or shoulder complaints from a university-based sports medicine clinic, during which PF-CAT, Single Assessment Numerical Evaluation (SANE), Simple Shoulder Test (SST), and American Shoulder and Elbow Surgeons (ASES) outcome scores for shoulder patients and PF-CAT, SANE, and International Knee Documentation Committee (IKDC) scores for knee patients were obtained, with an initial visit or one follow-up visit included in the study. Spearman correlation was used to evaluate pairwise agreement among scores. The McNemar χ 2 test was used to evaluate a difference in the number of times floor and ceiling values occurred. Wilcoxon signed rank tests were used to compare differences in completion times. Results In total, 415 shoulder and 450 knee clinical evaluations qualified for inclusion in the study. A high correlation was found between IKDC and PF-CAT scores ( r = 0.75, P r = 0.68, P r = 0.63, P P P = .0133), and 5.8% for the shoulder SANE (floor P = .0012, ceiling P = .0269). The PF-CAT had values of 0.4% for the shoulder and 0.6% for the knee. Zero percent of IKDC scores but 6.9% of knee SANE scores hit floor or ceiling values (floor P = .0019, ceiling P = .0007). The PF-CAT median completion time was lower at 55 seconds versus 268 seconds for the IKDC assessment ( P P Conclusions The PF-CAT showed a high correlation with IKDC scores and a moderately high correlation with ASES and SST outcomes. The PF-CAT takes significantly less time to complete and exhibits improved or similar floor and ceiling effects in comparison to IKDC, SST, and ASES scores. The PF-CAT can be used in evaluating sports medicine knee and shoulder patients. Level of Evidence Level III, cross-sectional study.