cssi/SciSciGPT-SciSciNet huggingface dataset:
Charles Taylor's Deeply Diverse Response to Canadian Fragmentation: A Project Often Commented On but Seldom Explored

This article attempts to clarify the controversies Charles Taylor's thoughts on group rights and identity politics have generated by exploring the constitutional and normative dimensions of Taylor's approach to the problem of political fragmentation, what he calls "deep diversity." In doing so, it makes a qualified defence of Taylor against his critics while also sketching an alternative route to deep diversity. The latter responds to the critics' concerns about the actual forms of accommodation or recognition that Taylor's thought sanctifies while preserving the normative core of his model.
ΔNp63α represses anti-proliferative genes via H2A.Z deposition

DNp63a is a member of the p53 family of transcription factors that functions as an oncogene in squamous cell carcinomas (SCCs). Because DNp63a and p53 bind virtually identical DNA sequence motifs, it has been proposed that DNp63a functions as a dominant-negative inhibitor of p53 to promote proliferation and block apoptosis. However, most SCCs concurrently overexpress DNp63a and inactivate p53, suggesting the autonomous action of these oncogenic events. Here we report the discovery of a novel mechanism of transcriptional repression by DNp63a that reconciles these observations. We found that although both proteins bind the same genomic sites, they regulate largely nonoverlapping gene sets. Upon activation, p53 binds all enhancers regardless of DNp63a status but fails to transactivate genes repressed by DNp63a. We found that DNp63a associates with the SRCAP chromatin regulatory complex involved in H2A/H2A.Z exchange and mediates H2A.Z deposition at its target loci. Interestingly, knockdown of SRCAP subunits or H2A.Z leads to specific induction of DNp63a-repressed genes. We identified SAMD9L as a key anti-proliferative gene repressed by DNp63a and H2A.Z whose depletion suffices to reverse the arrest phenotype caused by DNp63a knockdown. Collectively, these results illuminate a molecular pathway contributing to the autonomous oncogenic effects of DNp63a.
Telecomunication Revolution in Brazil and its Impact in Self Imagen Percepions

Brasil es testigo de una gran revolucion en su infraestructura de telecomunicaciones. De facto, es este el ultimo estagio de un ciclo de mas de 100 anos donde los sectores privados y estatales bien como nacionalistas e investidores cosmopolitas se han enfrentado para obtener el control de esta inmensa red. La disputa por el mercado brasileno ha alcanzado una nueva fase donde la globalizacion ha creado un sistema abierto, despecho del interes de la izquierda y de los estrategas brasilenos.
The modern carbonate ramp slope of central West Florida

ABSTRACT A holistic investigation of the modern carbonate ramp slope of central west Florida has been completed via analysis of approximately 1,500 km of air-gun seismic reflection profiles tied to two drillcores and bottom samples recovered at 92 stations. Our primary goal has been to characterize modern depositional processes and products; to compare and contrast results with modern rimmed-platform slopes; and to develop a model for application to the rock record. The "modern" depositional environment of the west Florida ramp slope was initiated 12-15 Ma when depositional style changed from seaward-prograding clinoforms to a pelagic, slope-front-fill system bound along the shelf margin by contour-parallel flow of the Loop Current. A seaward-thickening wedge (0-250 m) of late Miocene to Recent pelagic carbonate ooze has been deposited across antecedent mid-Miocene topography. In general, the sea floor dips 1-2° seaward from water depths of about 200-2,000 m, and slopes are relatively smooth. However, contemporary submarine geomorphology is controlled, in part, by earlier slope failures. The primary control of modern sedimentation along the west Florida slope is Loop Current flow, which acts as a dynamic oceanographic boundary between outer shelf and upper slope, winnows bottom sediments, catalyzes early submarine cementation, and stimulates pelagic production of calcium carbonate. The axis of Loop Current circulation has also migrated laterally in response to climatically controlled sea-level fluctuations, which has resulted in a relatively wide ( 25 km) band of winnowed sands and hardgrounds along the shelf margin. Climatic oscillations have also resulted in cyclic deposition of pelagically derived aragonite (pteropods) on the ramp slope that is out of phase with bank-derived aragonite cycles of rimmed platform slope . There are three major facies belts that parallel modern isobaths: 1) a hardground facies of intraclastic grainstones and rhodolith rudstones, as well as algal ridges, along the outer shelf at water depths of approximately 200-400 m; 2) a winnowed-sand facies of planktonic forams, intraclasts, glauconite, and reworked phosphorite grains as well as deep-water coral mounds along the shelf margin at depths of approximately 400-600 m; and 3) a bioturbated pelagic-ooze facies along the ramp slope at depths of approximately 600-2,000 m. These facies patterns, geometries, and grain types, along with a general paucity of sediment-gravity-flow deposits, readily distinguish this carbonate ramp slope from better-known rimmed-platform slopes of the Bahamas.
Who Killed Robbie and Cecilia? Reading and Misreading Ian McEwan's Atonement

ABSTRACT Ian McEwan's 2001 novel, Atonement, is seen by many as a meditation on misreading, and this article argues that the author not only dramatizes misreading and implicitly warns readers against misreading, but also induces his readers into misreading. Although critics of the novel claim that Robbie Turner and Cecilia Tallis die during World War II, in fact the book not only offers no explicit statement of their deaths, but also offers good reasons to believe that they did not die. Readers who believe in their deaths, then, are seen to commit the same sort of misreading as does the novel's narrator: this narrator's misreading causes Turner and Tallis great suffering, and the misreading by readers of Atonement “causes” these characters' deaths. Reinforcing McEwan's warning against misreading, then, is the novel's illustration of how easy it is to misread.
Effect of Amino Acids and Oxygen on Chemotaxis in Escherichia coli

Adler, Julius (University of Wisconsin, Madison). Effect of amino acids and oxygen on chemotaxis in Escherichia coli. J. Bacteriol. 92:121-129. 1966.-Motile cells of Escherichia coli placed at one end of a capillary tube containing a mixture of the 20 amino acids commonly found in proteins migrate out into the tube in two bands. The bands are clearly visible to the naked eye, and they can also be demonstrated by microscopy, photography, and densitometry, and by assaying for bacteria throughout the tube. The occurrence of more than one band is not due to heterogeneity among the bacteria, since each band can be used over to give rise to two again. The first band uses all the oxygen to oxidize portions of one or more of the amino acids, including serine, and the second band consumes the residual serine anaerobically. The results are interpreted to mean that E. coli shows chemotaxis toward oxygen and serine. When no energy source is added to the medium, a band of bacteria still appears. It consumes all the oxygen to oxidize an endogenous energy source. The addition of any one of 10 oxidizable amino acids stimulates the rate of travel of this band. Alanine, an example that was studied in detail, supports such a band that consumes all the oxygen to oxidize a portion of the alanine. Serine, the only amino acid that this strain can use either aerobically or anaerobically when grown under the conditions used here, gives rise to two bands.
Critical Tax Theory: Race and Class Matters in Tax Policy

The Earned Income Tax Credit (EITC) which is available only to low-income workers, is headed for extinction or at least the end of the EITC as we know it. Recently we were informed that 1.6 million low-income taxpayers had their tax refunds frozen over the last five years, although the vast majority did nothing wrong. Low-income taxpayers are far more likely to be audited than their high income counterparts. In fact, since 1998 over $1 billion has been spent auditing low-income taxpayers. This Essay shows that the EITC is headed for extinction because the EITC has a welfare taint. The EITC first received a welfare taint during the Clinton Administration and it has continued during the Bush Administration. In order to reverse the trend, EITC taxpayers will have to be painted in a more sympathetic or deserving light. This Essay suggests that the truth actually will help here, given that the racial analysis of the EITC shows that the vast majority of EITC taxpayers are white. Because scholars have ignored the race and class effects of the EITC, they offer no solution to improve the plight of low-income taxpayers. Building upon Professor Derrick Bell's interest-convergence thesis, I predict that if the race and class information can be properly packaged, the EITC's elimination can be prevented.
Auditory-Evoked Response Morphology in Profoundly-Involved Multi-Handicapped Children: Comparisons with Normal Infants and Children

The developmental and difference/defect theories have been used to explain auditory development in some multi-handicapped children. If developmental factors influence auditory response behaviors, it might be predicted that evoked potentials measured from the central auditory nervous system would reflect similar developmental influences in multi-handicapped children. The purpose of this study was to compare auditory-evoked-potential waveform morphology between profoundly-involved multi-handicapped children and normal infants and children. Auditory brainstem response (ABR) and middle-latency response (MLR) morphology were examined from waveform descriptions, wave detection, latency, amplitude, and spectral energy measures. The majority of handicapped subjects exhibited response morphology unlike that of normal children or infants. ABR/MLR morphology for handicapped children was characterized by depressed responses and substantial waveform variability. The results of this study tended to support the differen...
Contour Threads Technique Pearls

Several technique elements can be implemented by the surgeon to improve results and potentially improve longevity and predictability of contour thread (Surgical Specialties, Reading, PA) lifting. These include: Ensure consistent and accurate fifi xation of the threads to the galea, preferably posterior (cephalad) to the existing hair line.
On the Critical Layer Thickness of Strained-Layer Heteroepitaxial CoSi2 Films on 〈111〉Si

The technique of Double Crystal X-Ray Diffractometry (DXD) and ion beam channeling are applied to investigate, as a function of thickness, the average perpendicular strain and crystal quality of CoSi2 layers grown by MBE on 〈111〉Si. The results show that thin layers (from 20 to 30 nm) are partially relaxed but with a strain greater than that expected for a free CoSi2 lattice. For layers thicker than 30nm the magnitude of the CoSi2 strain incrgases to 1.7%, somewhat less than the maximum magnitude strain expected for coherent growth (2.1%). For layers thicker than 50 nm, the perpendicular strain relaxes very slowly, with the strain at 225 nm only 5% less than that at 50nm. It was concluded that a coherent epitaxial layer does not form initially and the relaxation of the strained layers is not consistent with a planar growth mechanism of the CoSi2 epilayers. Therefore the concept of a critical thickness, below which the epilayers are strained and above which the epilayers are relaxed, cannot be applied to our CoSi2/Si system.
Mechanisms of anticonvulsant drug action. I. Drugs primarily used for generalized tonic-clonic and partial epilepsies.

The usefulness of the anticonvulsant drugs is determined by the mechanism by which the agent acts and its pharmacokinetics. The general mechanisms of action of these agents include (1) effects on neurotransmitter action, (2) effects on repetitive neuronal firing mechanisms, (3) effects on neuronal networks, and (4) effects on neuronal ionic transport. Ethosuximide, valproic acid and clonazepam are used primarily in absence epilepsy. Valproic acid is also effective against generalized tonic-clonic epilepsy. Diazepam is used primarily in status epilepticus. Valproic acid enhances gamma aminobutyric acid (GABA)-mediated inhibition, reduces repetitive firing, and reduces both inhibition and excitation in neuronal networks. Clonazepam and diazepam enhance the inhibitory action of GABA, decrease inhibition in neuronal networks and affect calcium ion transport with lesser effects on repetitive firing. Ethosuximide reduces inhibition in neuronal networks, may interact with dopamine, and possibly affects sodium and potassium ion transport. Further work is needed to assess the degree of involvement of these effects in the anticonvulsant action versus the adverse effects of these agents.
Development of a 3D Microfluidic Culture Model to Study the Effect of Shear Stress on Tumor Angiogenesis

Current in vitro studies of tumor angiogenesis and metastasis are limited by the use of static 2D culture systems or 3D models that poorly reflect the pathological tumor microenvironment. While these systems have provided insight into tumor-inherent mechanisms of neovascularization, they are unable to couple local cellular response with specific biochemical and mechanical cues [1]. Interstitial flow plays an important role in regulating tumor growth; however, there are currently no in vitro cell culture models specifically designed to investigate the effect of fluid shear on tumorigenesis. By integrating tissue-engineering strategies with microfluidics and particle image velocimetry, we have developed a 3D in vitro cell culture model that allows the relationship between shear stress and tumor-endothelial cell cross-talk to be monitored. This research strategy will greatly improve our understanding of shear-stress mediated angiogenesis.Copyright © 2011 by ASME
Lidar measurement of snow depth: a review

Laser altimetry (lidar) is a remote-sensing technology that holds tremendous promise for mapping snow depth in snow hydrology and avalanche applications. Recently lidar has seen a dramatic widening of applications in the natural sciences, resulting in technological improvements and an increase in the availability of both airborne and ground-based sensors. Modern sensors allow mapping of vegetation heights and snow or ground surface elevations below forest canopies. Typical vertical accuracies for airborne datasets are decimeter-scale with order 1 m point spacings. Ground-based systems typically provide millimeter-scale range accuracy and sub-meter point spacing over 1 m to several kilometers. Many system parameters, such as scan angle, pulse rate and shot geometry relative to terrain gradients, require specification to achieve specific point coverage densities in forested and/or complex terrain. Additionally, snow has a significant volumetric scattering component, requiring different considerations for error estimation than for other Earth surface materials. We use published estimates of light penetration depth by wavelength to estimate radiative transfer error contributions. This paper presents a review of lidar mapping procedures and error sources, potential errors unique to snow surface remote sensing in the near-infrared and visible wavelengths, and recommendations for projects using lidar for snow-depth mapping.
Influence of Thermal Incubation Stresses

Abstract A SIGNIFICANT pre-hatching alteration of the sex-ratio in poultry would have tremendous impact upon the industry. An increase in percentage of eggs which hatch into functional females would be worth thousands of dollars to hatcheries producing egg-laying stocks. On the other hand, an increase in males would provide faster growing broilers, turkeys and waterfowl, for meat production. In 1963 a preliminary study of the effect of gamma radiation on the developing embryo produced a high incidence of males from eggs which were treated on the ninth day of incubation (Morgan and Whitehead, 1964). Subsequent exposure of 480 eggs in a later trial, resulted in a hatch of 215 males and 174 females (Morgan, 1966), a departure which is significant at the 5% level from the theoretically expected 50:50 ratio. Inasmuch as the altered ratio was not associated with exposure in the latter study, another experiment was specifically designed to determine . . .
Insight into the Effect of Long Range Interactions for the Adsorption of Benzene on Transition Metal (110) Surfaces

In recent years, evaluating the effect of van der Waals (vdW) forces for many physical systems, including the adsorption of small organic molecules on metal surfaces, became possible thanks to the continuous improvements in vdW density functional theory (DFT). In this work, employing the vdW-DF (revPBE-vdW), the optimized vdW-DF (optB88-vdW, optPBE-vdW, optB86b-vdW), and vdW-DF2 (rPW86-vdW2) methods, we study the adsorption of benzene on a range of (110) transition metal surfaces. We evaluate the performance of the vdW functionals by examining the equilibrium adsorption geometries and energies and comparing the results with the available experimental data and the PBE calculations. Our results show that the optimized vdW-DF functionals predict the equilibrium geometries in good quantitative agreement with some of the available experimental reports. We show the crucial importance of the vdW interactions for accurate description of equilibrium geometries and energies of benzene on transition metal (110) surf...
A Coda-Length Magnitude Scale For New England

An empirical coda-length (signa] duration) magnitude scale is developed to estimate magnitudes for earthquakes in New England. The formula is based on the mean signal duration, T (in seconds), measured from 45 local earthquakes and is given by: m b = ( Lg ) = 2.21 * log 10 ( T ) - 1.70 For epicentral distances less than 600 km, the distante dependence is found to be negligibly small in comparison to other errors. Regional variations in signal duration suggest higher attenuation in southeastern New England than in New Hampshire.
‘One Country, Two Systems’

This chapter will not go into detail concerning the development of both Hong Kong and Taiwan since their separation from Imperial China under the Ching Dynasty during the nineteenth century. However, certain aspects of changes and the evolution of their significance will be touched upon to highlight the contemporary problems and conflicts surrounding both. For Hong Kong, for example, much emphasis will be placed on its evolution, the impending crisis of its return to China, the process of Sino-British negotiation since the early 1980s, the joint declaration of 1984, Hong Kong as a challenge to the People’s Republic of China (the PRC), and the Hong Kong settlement and its impact on the solution of Taiwan.
Impact statement: From the nurse manager's perspective

As a nurse manager, I spend countless hours developing a 24/7 schedule. Some employees prefer to spend their weekends at home while others appreciate the overtime. Additionally, nurses often have a...
Human Acute Stress Detection via Integration of Physiological Signals and Thermal Imaging

Daily pressure, work load, and family responsibilities among other factors impose increasing levels of stress on different individuals. Hence, detecting stress as early as possible can potentially reduce the severe consequences and risks that someone may experience. In this paper, we develop a novel dataset to detect acute stress using 50 subjects. We additionally analyze different features extracted automatically from the thermal and physiological modalities. Furthermore, we develop a system that integrates both thermal and physiological features for improved stress detection rates. Our system achieves promising results exceeding 75% accuracy and has the potential to be further improved by adding additional modalities, which can provide a useful and reliable approach in early detection of stress.
Seismic Performance of World Heritage Sites in Kathmandu Valley during Gorkha Seismic Sequence of April–May 2015

AbstractThis paper outlines the damage observed in seven world heritage sites within the Kathmandu Valley because of the Gorkha seismic sequence of April–May 2015. Field reconnaissance was performe...
Increasing Juniperus virginiana L. pollen in the Tulsa atmosphere: long-term trends, variability, and influence of meteorological conditions

In the Tulsa area, the Cupressaceae is largely represented by eastern red cedar (Juniperus virginiana L.). The encroachment of this species into the grasslands of Oklahoma has been well documented, and it is believed this trend will continue. The pollen is known to be allergenic and is a major component of the Tulsa atmosphere in February and March. This study examined airborne Cupressaceae pollen data from 1987 to 2016 to determine long-term trends, pollen seasonal variability, and influence of meteorological variables on airborne pollen concentrations. Pollen was collected through means of a Burkard sampler and analyzed with microscopy. Daily pollen concentrations and yearly pollen metrics showed a high degree of variability. In addition, there were significant increases over time in the seasonal pollen index and in peak concentrations. These increases parallel the increasing population of J. virginiana in the region. Pollen data were split into pre- and post-peak categories for statistical analyses, which revealed significant differences in correlations of the two datasets when analyzed with meteorological conditions. While temperature and dew point, among others were significant in both datasets, other factors, like relative humidity, were significant only in one dataset. Analyses using wind direction showed that southerly and southwestern winds contributed to increased pollen concentrations. This study confirms that J. virginiana pollen has become an increasing risk for individuals sensitive to this pollen and emphasizes the need for long-term aerobiological monitoring in other areas.
Design and implementation of a MRAS sliding mode observer for the inverse of the rotor time constant of the induction motor

The paper presents an estimator for the inverse of the rotor time constant of the induction motor. Estimation is done using a sliding mode observer under the assumption that the stationary frame fluxes are known. With measured voltages, currents, and with known fluxes and speed, the paper develops an MRAS-type sliding mode observer. This works well under ideal conditions; however, if the speed is inaccurate or if the magnetising inductance saturates, the accuracy suffers. The paper develops a model for the saturated induction motor and attempts to also estimate the saturation level. In the second part, an observer with only a single set of feedback terms is developed. This is transformed into a sensorless observer by feeding it with a speed estimate (assumed inaccurate). The error in the estimated rotor time constant can be reduced by operating the motor drive with a low ratio of id to iq.
Ventricular Resynchronization: Pathophysiology and Identification of Responders

Patients with dilated cardiomyopathy and discoordinate wall motion due to intraventricular conduction delay are at increased risk for exacerbated pump failure and arrhythmias and suffer higher mortality rates. Biventricular and left ventricular resynchronization pacing therapies acutely improve systolic ventricular function and energetic efficiency in patients with heart failure and left-bundle‐type intraventricular conduction delay. Sustained therapy can further inhibit or reverse chronic chamber dilation and remodeling. As with all therapies for heart failure, individual subject responses are variable; however, the invasive nature and expense of resynchronization therapy has particularly highlighted the need to prospectively identify optimal candidates. Although QRS duration has been principally used to date, increasing evidence shows this to have poor acute and chronic correlations with patient response. In contrast, direct measures of mechanical dyssynchrony based on simple echo imaging and more complex tissue Doppler and magnetic resonance imaging‐based approaches appear to afford better predictive accuracy. [Rev Cardiovasc Med. 2003;4(suppl 2):S3‐S13]
Histamine-induced depolarization: ionic mechanisms and role in sustained contraction of rabbit cerebral arteries

The role of membrane depolarization in the histamine-induced contraction of the rabbit middle cerebral artery was examined by simultaneous measurements of membrane potential and isometric force. Hi...
Exploring Organizational Human Resource Information System Security.

We explore HRIS security by presenting information security fundamentals and how they pertain to organizations. With increasing use of enterprise systems such as HRIS, security of such systems is an area that is worthy of concern. Even then, there is surprisingly little research in this area, albeit extensive work is present with regard to HRIS privacy. While focusing on HRIS security we introduce aspects of HRIS security and how it can be enhanced in organizations. Because of its complex, sensitive nature, we suggest that qualitative research is the optimal method of further investigating HRIS security. We also propose six research questions as part of deepening our understanding of HRIS research in the future.
The Social Construction of Educational Psychology (Continued): Implications for Teacher Education

This chapter brings the discussion from the previous chapter into more recent times. That is, the social construction of psychological concepts within the contemporary context is examined. After analyzing some of the larger implications of this hegemonic conditioning, a review of how teacher education students have internalized these constructs is explored. The final section examines the critical constructivism/postformalism of Kincheloe as a critical pedagogical approach to solving the problem of what we might refer to as the colonialist legacy of psychology situated within this neoliberal age of global capitalism.
Screening Library Selection and High-Throughput Screening Analysis/Triage

This chapter reviews a large number of concepts, techniques, and processes that can be used to generate a subset. The initial focus was on the preparatory work that should be done on the compound collection to arrive at a suitably filtered starting set based on agreement as to what compounds were important to retain. This preparatory work also included defining the use of the subset, the number of compounds in the subset, and touching on a number of pragmatic issues, such as single versus multiple compounds per well and freeze–thaw cycles. Having obtained a suitable starting set of compounds, a number of techniques for selecting compounds were reviewed. In general, there seems to be agreement that rational methods of selecting compounds is superior to a strictly random selection. The last section dealt with providing some assessment of the expected performance of the subset and described some of the techniques used in iterative follow up once the subset has been screened.
Durable Goods and Sectoral Effects of Monetary Policy

High degree of interest sensitivity of durable goods is now a stylized fact in the literature of monetary policy. This literature, however, does not provide a clear and consensual explanation for the modalities of this stylized fact. In this paper, two independent empirical models are performed to shed more light on the cross-sectoral impacts of monetary policy. The results of first study indicate that there is no straightforward qualitative relationship between the degree of durability and the interest-sensitivity of durables. While, the second study shows that, in response to monetary policy shocks, productive durables behave differently from consumer durables. For both studies, two models have been estimated using the quarterly data of the U.S. over the period 1954:III – 2007:II JEL Classification: E52, L68.
Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells.

Preclinical Research & Development Pancreatic cancer is the third leading cause of death in the US with a poor 5-year survival rate of 8.5%. A novel anti-cancer drug, dimethylamino parthenolide (DMAPT), is the water-soluble analog of the natural sesquiterpene lactone, parthenolide. The putative modes of action of DMAPT are inhibition of the Nuclear chain factor kappa-light-chain enhancer of activated B cells (NFκB) pathway and depletion of glutathione levels; the latter causing cancer cells to be more susceptible to oxidative stress-induced cell death. Actinomycin-D (ActD) is a polypeptide antibiotic that binds to DNA, and inhibits RNA and protein synthesis by inhibiting RNA polymerase II. A phase 2 clinical trial indicated that ActD could be a potent drug against pancreatic cancer; however, it was not a favored drug due to toxicity issues. New drug entities and methods of drug delivery, used alone or in combination, are needed to treat pancreatic cancer more effectively. Thus, it was postulated that combining DMAPT and ActD would result in synergistic inhibition of Panc-1 pancreatic cancer cell growth because DMAPT's inhibition of NFκB would enhance induction of apoptosis by ActD, via phosphorylation of c-Jun, by minimizing NFκB inhibition of c-Jun phosphorylation. Combining these two drugs induced a higher level of cell death than each drug alone. A fixed drug ratio of DMAPT: ActD (1,200:1) was used. Data from metabolic (MTT) and colony formation assays were analyzed for synergism with CompuSyn software, which utilizes the Chou-Talalay equation. The analyses indicated synergism and moderate synergism at combination concentrations of DMAPT/ActD of 12/0.01 and 18/0.015 μM, respectively.
Split-Brain Babies? Differences in Representation of Bilaterally and Unilaterally Presented Visual Stimuli in Infancy

Information needed for perception and action is often distributed across the two hemispheres of the human brain. During development, representations lateralized due to topographic sensory maps may be available independently before they can be integrated across hemispheres. These studies (total N = 211) investigate visual interhemispheric integration in two domains in infancy. In Experiment 1, infants (8-14 months) showed stronger evidence of representing the equality of two shapes when the shapes were presented in the same visual hemifield. In Experiments 2-4, infants (10-19 months) showed evidence of greater familiarization when shown 16 dots in one hemifield than when shown 8 dots in each hemifield. The possibility that interhemispheric integration poses an unusually late-resolved challenge in infant vision is discussed.
Book Review - Weapons of Math Destruction: How Big Data Increases Inequality and Threatens Democracy

“Big Data processes codify the past. They do not invent the future.” ― Cathy O’Neil, Weapons of Math Destruction: How Big Data Increases Inequality and Threatens DemocracyThe book talks about how i...
Correlation functions in the CFTd/AdSd+1 correspondence

Abstract Conformal techniques are applied to the calculation of integrals on AdS d +1 space which define correlators of composite operators in the superconformal field theory on the d -dimensional boundary. The 3-point amplitudes for scalar fields of arbitrary mass and gauge fields in the AdS supergravity are calculated explicitly. For three gauge fields we compare in detail with the known conformal structure of the SU (4) flavor current correlator 〈 J i a J j b J k c 〉 of the N = 4, d = 4 SU ( N ) SYM theory. Results agree with the free field approximation as would be expected from superconformal non-renormalization theorems. In studying the Ward identity relating 〈J i a O I O J 〉 to 〈 O I O J 〉 for (non-marginal) scalar composite operators O I , we find that there is a subtlety in obtaining the normalization of 〈 O I O J 〉 from the supergravity action integral.
Sleep-deprived fatigue pattern analysis using large-scale selfies from social media

The complexities of fatigue have drawn much attention from researchers across various disciplines. Short-term fatigue may cause safety issue while driving; thus, dynamic systems were designed to track driver fatigue. Long-term fatigue could lead to chronic syndromes, and eventually affect individuals physical and psychological health. Traditional methodologies of evaluating fatigue not only require sophisticated equipment but also consume enormous time. In this paper, we attempt to develop a novel and efficient method to predict individual's fatigue rate by scrutinizing human facial cues. Our goal is to predict fatigue rate based on a selfie. To associate the fatigue rate with user behaviors, we have collected nearly 1-million timeline posts from 10,480 users on Instagram. We first detect all the faces and identify their demographics using automatic algorithms. Next, we investigate the fatigue distribution by weekday over different age, gender, and ethnic groups. This work represents a promising way to assess sleep-deprived fatigue, and our study provides a viable and efficient computational framework for user fatigue modeling in large-scale via social media.
Bayesian model selection for high-dimensional data

Abstract High-dimensional data, where the number of features or covariates can even be larger than the number of independent samples, are ubiquitous and are encountered on a regular basis by statistical scientists both in academia and in industry. A majority of the classical research in statistics dealt with the settings where there is a small number of covariates. Due to the modern advancements in data storage and computational power, the high-dimensional data revolution has significantly occupied mainstream statistical research. In gene expression datasets, for instance, it is not uncommon to encounter datasets with observations on at most a few hundred independent samples (subjects) and with information on tens or hundreds of thousands of genes per each sample. An important and common question that arises quickly is—“which of the available covariates are relevant to the outcome of interest?” This concerns the problem of variable selection (and more generally model selection) in statistics and data science. This chapter will provide an overview of some of the most well-known model selection methods along with some of the more recent methods. While frequentist methods will be discussed, Bayesian approaches will be given a more elaborate treatment. The frequentist framework for model selection is primarily based on penalization, whereas the Bayesian framework relies on prior distributions for inducing shrinkage and sparsity. The chapter treats the Bayesian framework in the light of objective and empirical Bayesian viewpoints as the priors in the high-dimensional setting are typically not completely based subjective prior beliefs. An important practical aspect of high-dimensional model selection methods is computational scalability which will also be discussed.
A single-center retrospective cohort analysis of venetoclax in relapsed/refractory multiple myeloma.

Venetoclax, a small molecule inhibitor of BCL-2, has promising pre-clinical and early clinical activity in relapsed refractory multiple myeloma (RRMM). However, the clinical use of venetoclax remai...
CORRELATION FUNCTIONS FOR MN/SN ORBIFOLDS

We consider a bosonic CFT on a noncommutative orbifold Mn/Sn. To calculate three and four point functions of the twist operators on such an orbifold we perform a conformal map to the covering space and evaluate an appropriate Liouville action. We give an expression for the three point function for the case when the covering space is a sphere.
Lowering the Cramer-Rao lower bounds of variance in randomized response sampling

In this paper, we lower the Cramer-Rao Lower bound of variance due to Singh and Sedory (2011, 2012) for the Odumade and Singh (2009) model in the sense that we propose a randomized response model t...
The Use and Value of Badges: Leveraging Salesforce Trailhead Badges for Marketing Technology Education:

Recent calls to the academy challenge marketing educators to prepare new graduates for a complex, high-stakes marketing environment driven by technology. We explore the value of utilizing readily a...
Social and emotional learning is hegemonic miseducation: students deserve humanization instead

The ahistorical objectives of social and emotional learning fall short of repairing the cultural contempt of hegemonic miseducation and does not address the primary social forces negatively impacti...
Burying the Kasuku Syndrome: Constructing Inventive Sites of Knowledge

Having come here to advocate the immediate burial of ‘kasuku culture,’ alias, ‘parrot culture,’ I had better initiate the process of grave-digging myself. As an African academician, poet, playwright, artist, cultural worker and activist, I have sought to do this in different ways. One such way has been using my intellectual work to affirm progressive indigenous African paradigms, including orature, which Pio Zirimu and Austin Bukenya once concisely defined as ‘verbal art.’1 I will, therefore, use an African Orature style of delivery to hold this conversation with you. I cannot think of a more appropriate tool of competing with fatigue at the end of a long day, or of keeping a possible dozing audience alive, following such a challenging dinner. My talk, or palaver, will be divided into movements or cycles, labelled palaver one to ten. Inside each of these full stream palavers will be meandering tributaries of smaller, but related palavers. If the meanderings interfere with your focus, therefore, just find ways of tolerating them. For instance, treat them as the musings of an elder-in-the-making, borrowing a leaf from the wazee wakumbuka (elders recollect), an extremely popular kipindi (program) that used to air on Kenya Broadcasting Corporation (KBC) radio network sometime in the 1970s.
GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries

Peripheral nerve injuries commonly occur due to trauma, like a traffic accident. Peripheral nerves get severed, causing motor neuron death and potential muscle atrophy. The current golden standard to treat peripheral nerve lesions, especially lesions with large (≥ 3 cm) nerve gaps, is the use of a nerve autograft or reimplantation in cases where nerve root avulsions occur. If not tended early, degeneration of motor neurons and loss of axon regeneration can occur, leading to loss of function. Although surgical procedures exist, patients often do not fully recover, and quality of life deteriorates. Peripheral nerves have limited regeneration, and it is usually mediated by Schwann cells and neurotrophic factors, like glial cell line-derived neurotrophic factor, as seen in Wallerian degeneration. Glial cell line-derived neurotrophic factor is a neurotrophic factor known to promote motor neuron survival and neurite outgrowth. Glial cell line-derived neurotrophic factor is upregulated in different forms of nerve injuries like axotomy, sciatic nerve crush, and compression, thus creating great interest to explore this protein as a potential treatment for peripheral nerve injuries. Exogenous glial cell line-derived neurotrophic factor has shown positive effects in regeneration and functional recovery when applied in experimental models of peripheral nerve injuries. In this review, we discuss the mechanism of repair provided by Schwann cells and upregulation of glial cell line-derived neurotrophic factor, the latest findings on the effects of glial cell line-derived neurotrophic factor in different types of peripheral nerve injuries, delivery systems, and complementary treatments (electrical muscle stimulation and exercise). Understanding and overcoming the challenges of proper timing and glial cell line-derived neurotrophic factor delivery is paramount to creating novel treatments to tend to peripheral nerve injuries to improve patients' quality of life.
Impact of adding an IgG4 conjugate to routine direct immunofluorescence testing for subepithelial and intraepithelial autoimmune blistering disorders.

Background Certain autoimmune bullous dermatoses are mediated by autoantibodies of the IgG4 subclass. We determined the diagnostic impact of adding IgG4 to our conventional direct immunofluorescence (DIF) panel. Methods For all cases submitted to our referral laboratory for DIF over one month (n=630), we performed IgG4 DIF and collected consecutive biopsy specimens showing definite or indeterminate linear or cell-surface deposition of IgG, IgG4, and/or C3. On retrospective blinded review, we classified the pattern and whether findings were definite, indeterminate or negative. Background staining was reported if substantial. Results Seventy DIF specimens met inclusion criteria. Of 22 (31.4%) specimens equivocal for linear or cell-surface deposition, 9 (40.9%) had definitive IgG4 findings, either linear (3 of 14 equivocal linear cases; 21.4%) or cell-surface (6 of 8 equivocal cell-surface cases; 75.0%). 40.9%). Background deposition was substantial in 14 cases (20.0%) for IgG but in none for C3 and IgG4. Conclusion IgG4 allowed for classification of over 40% of cases that were otherwise equivocal by IgG and C3. IgG4 staining showed lower levels of non-specific background staining than did IgG or C3. IgG4 appears to contribute the most value in cases with cell-surface deposition and with equivocal linear IgG deposition and negative C3 results. This article is protected by copyright. All rights reserved.
Policy effectiveness of U.S. governors: The role of gender and changing institutional powers

Synopsis The demographic, cultural and gender representation of state governors has changed dramatically over the past four decades. Further, the institutional powers of governors have continued to increase over the past few decades. The role of women governors in the policy arena is of particular interest with more women elected and appointed to these positions every year. A review of the literature related to gender differences in leadership styles, group behaviors, and policy interests is presented, followed by a binomial generalized linear model testing the relationship between gender, gubernatorial powers and gubernatorial policy effectiveness. As more women serve as high ranking policy executives, understanding the role of gender is both a timely and relevant research question.
Urgent Compassion: Medical Marijuana, Prosecutorial Discretion and the Medical Necessity Defense

For centuries physicians and patients have extolled the medical benefits of marijuana. The federal government, however; refuses to retreat from its dogged war on drugs, preventing those in serious medical need from realizing marijuana's therapeutic potential. Numerous states have shown their opposition to the federal government's position, as well as their compassion for the seriously ill, lry' placing pro-medical marijuana initiatives on their election ballots or by introducing such legislation in their state legislatures. Furthermore, the United States Court of Appeals for the Ninth Circuit has recently rendered two landmark decisions holding that the common law medical necessity defense is available to medical marijuana defendants who are criminally prosecuted under federal law, despite the federal government's general marijuana prohibition. Because a change in federal drug policy is unlikely in the near future, one way federal prosecutors can avoid this conflict with the federal judiciary, as well as respect the will of the people in states that have passed pro-rnedical marijuana laws, is to exercise appropriate prosecutorial discretion, refusing to prosecute medical marijuana patients. This especially should be the case in states where the citizens have clearly expressed their values regarding medical marijuana through the initiative or legislative process.
New Representations of Some Probability Density and Cumulative Distribution Functions for Correlative Fading Applications

In this chapter we focus on the Rayleigh, Nakagami- m , and lognormal fading channels since they are the most commonly used in digital communication system analyses and, as discussed previously, are typical of many wireless environments.
Systematische Integration von Prozeß- und Produktmanagement

Versions-und Konfigurationsmanagement sind zentrale Instrumente zur intellektuellen Beherrschung komplexer Softwareentwicklungen. In stark wiederverwendungsorientierten Softwareentwik-klungsansatzen—wie vom SFB 501 bereitgestellt— mus der Begriff der Konfiguration von traditionell produktorientierten Artefakten auf Prozesse und sonstige Entwicklungserfahrungen erweitert werden. In dieser Veroffentlichung wird ein derartig erweitertes Konfigurationsmodell vorgestellt. Daruberhinaus wird eine Erganzung traditioneller Projektplanungsinformationen diskutiert, die die Ableitung masgeschneiderter Versions- und Konfigurationsmanagementmechanismen vor Projektbeginn ermoglichen.
Friction, Frontogenesis, and the Stratification of the Surface Mixed Layer

The generation and destruction of stratification in the surface mixed layer of the ocean is understood to result from vertical turbulent transport of buoyancy and momentum driven by air–sea fluxes and stresses. In this paper, it is shown that the magnitude and penetration of vertical fluxes are strongly modified by horizontal gradients in buoyancy and momentum. A classic example is the strong restratification resulting from frontogenesis in regions of confluent flow. Frictional forces acting on a baroclinic current either imposed externally by a wind stress or caused by the spindown of the current itself also modify the stratification by driving Ekman flows that differentially advect density. Ekman flow induced during spindown always tends to restratify the fluid, while wind-driven Ekman currents will restratify or destratify the mixed layer if the wind stress has a component up or down front (i.e., directed against or with the geostrophic shear), respectively. Scalings are constructed for the relative importance of friction versus frontogenesis in the restratification of the mixed layer and are tested using numerical experiments of mixed layer fronts forced by both winds and a strain field. The scalings suggest and the numerical experiments confirm that for wind stress magnitudes, mixed layer depths, and cross-front density gradients typical of the ocean, wind-induced friction often dominates frontogenesis in the modification of the stratification of the upper ocean. The experiments reveal that wind-induced destratification is weaker in magnitude than restratification because the stratification generated by up-front winds confines the turbulent stress to a depth shallower than the Ekman layer, which enhances the frictional force, Ekman flow, and differential advection of density. Frictional destratification is further reduced over restratification because the stress associated with the geostrophic shear at the surface tends to compensate a down-front wind stress.
Key ingredients to the success of an organization's knowledge management strategy

Knowledge management is a key strategy that organizations are embracing to manage their organizational knowledge for strategic advantage. Unfortunately, like any new and maturing field, overexpectations are being created by so-called knowledge management consultants and vendors. This paper describes the six essential ingredients in order for knowledge management to have a chance of succeeding in an organization. Copyright © 1999 John Wiley & Sons, Ltd and Cornwallis Emmanuel Ltd.