cssi/SciSciGPT-SciSciNet huggingface dataset:
Culture Process and Intellectual Current: Durkheim and Atatürk1

IN THE Middle and Near East, as elsewhere in the changing world, local forms of nationalism have their origins in culture and culture history. Two major cultural domains have existed in the area, the Arab and the Turkish. These two, differing from each other largely in language rather than in basic pattern, were once loosely unified under the aegis of the caliphate, but political events, particularly after World War I, have drawn them increasingly apart. The respective Arab nations have gone their separate ways, each to develop its own volatile brand of nationalist aspirations, aims which became particularly explosive after the founding of Israel. But the Turks underwent their social and nationalist revolution somewhat earlier. Increasingly indifferent to its historical ties with the Islamic world, Turkey began to think of itself as a wholly autonomous nation-culture. The Turkish quest for self-assertion was fostered by Kemal Atattirk, who provided a special kind of rationale. What this was and how it developed reflect a culture process of particular significance. Atattirk and his associates, urbanized and Westernized intellectuals, set out deliberately to "modernize" Turkish culture and to develop a Westernized Turkish state which could exist on a par with the nations of Europe. To do this, they were confronted with the necessity of defining a Turkish ethos and of making Western elements one with it. Hence, as a basis for their actions, they were obliged to commit themselves to a system of social and political thought, a set of ground rules for the cultural modifications they sought to make. Obviously, there is an organic relationship, especially on the level of the literate cultures, between social system and philosophical premise. A constitutional type of government, for example, whether that of the United States, Britain, or the Soviet Union, reflects a system of conceptual values and in turn provides a rationale for behavior. The Turks borrowed elements of Western culture widely and intensively. As a result of the Kemalist revolution they took over Western material traits, designed a European-type government, and engaged in a wholesale importation of Western legal systems. But more than this, the party of Atatiirk found rational justification in an ideology which, although imported, permitted a course of nationalist action. Interested in culture change, in the processes of diffusion and integration, the anthropologist can find a classic example of culture building in the creation of the modern state and the modified society among the Turks. But further, that the rationale for Turkish national action should lie in the work of Emile Durkheim lends an anthropological interest of another kind.
Robust coding schemes for distributed sensor networks with unreliable sensors

A distributed sensor network in which several observations are communicated to the fusion center using limited transmission rate is considered in this paper. The observations must be separately coded and introduces a class of robust distributed coding schemes, which flexibly trade off between system robustness and compression efficiency.
Intramitochondrial positions of ubiquinone and iron-sulphur centres determined by dipolar interactions with paramagnetic ions

E.p.r. (electron-paramagnetic-resonance) spectra of ubisemiquinone (QH) organic radicals and all of the known iron-sulphur centres were studied in normal and 'nickle-plated' pigeon heart mitochondria, submitochondrial particles and submitochondrial particles from which succinate dehydrogenase had been removed. Incubation of pigeon heart mitochondria, submitochondrial particles or succinate dehydrogenase-depleted submitochondrial particles with substrate in the presence of pure O2 results in the accumulation of Q-H. In mitochondria, the e.p.r. spectrum of Q-H is characterized by in-homogeneous line broadening. A heterogeneous population of semiquinones appears to be partly responsible for these effects in mitochondria. Additon of Ni(II) to mitochondria renders saturation of the Q-H resonance more difficult. On the other hand, the resonance in either submitochondrial particles or succinate dehydrogenase-depleted particles is narrower than the same spectrum in mitochondria, and saturates like a homogeneous line. The presence of Ni(II) in either of these preparations, further, has no effect on either the A-H spectrum or the saturation curve. Therefore QH appears to be situated on the exterior surface of the mitochondrion. Likewise, the e.p.r. spectra and saturation curves of iron-sulphur centre N-2 exhibit characteristics of inhomogeneous line broadening, not only in intact mitochondria but also in both submitochondrial particles and succinate dehydrogenase-depleted particles. Because of the small pool size of centre N-2, this effect is likely to arise from a spin interaction with some other component in the membrane. Ni(II) has no effect on the saturation in centre N-2 in mitochondria or submitochondrial particles, and only a marginal effect in the succinate dehydrogenase-depleted preparation. These results are indeterminate with respect to the position of centre N-2 in the membrane; but suggest that its distance from the succinate dehydrogenase binding site is on the order of 1 nm. All of the other ferredoxin-type iron-sulphur centres in both preparations were not affected by paramagnetic ions. Homogeneous e.p.r. spectra and saturation curves are observed for both of the HiPIP-type (high-potential iron-sulphur protein-type) iron-sulphur centres in mitochondrial centres S-3 and bc-3. Addition of No(II) to intact mitochondria results in a dipolar interaction with centre bc-3. No effect was observed on centre S-3 in either preparation. A comprehensive model is presented for the structure of the respiratory electron-transport system in mitochondria, based on e.p.r. relaxation studies in the present and the preceding paper. There is no direct evidence for transmembrane electron flow through any of the known energy-coupling sites in mitochondria, so that direct hydrogen atom transfer across the membrane (as a combination of H+ translocation coupled to electron flow) does not occur...
Malaria and the DDT Story

Malaria kills millions of people each year and hundreds of millions more suffer chronic illness. Economic development is inhibited and poverty is perpetuated. Tren and Bate argue that action against malaria is over-centralised and narrowly focused, ignoring local conditions and concerns. Health agencies in developing countries and some companies are trying to stem a resurgent tide of malaria. Their work is, however, hampered by pressure from environmentalist groups and donor agencies which still crusade against the use of DDT and which have won a partial victory under the POPs (persistent organic pollutants) convention. A continuing anit-DDT campaign would have as its victims people in some of the world's poorest countries.
Chimpanzee to chimpanzee American sign language. Communication during high arousal interactions

The current study examined how five chimpanzees combined the signs of American Sign Language with their nonverbal communication during high arousal interactions. Thirty-five hours of videotape were analyzed for the presence of high arousal interactions. Similar to deaf children, the chimpanzees signed to one another during high arousal interactions, and they emphatically modulated their signs by signing more vigorously, enlarging the sign’s movement, prolonging the sign, reiterating the sign, or by using a two-handed version of a sign regularly signed with one hand. The majority of the chimpanzees’ sign utterances were contextually consistent. The chimpanzees’ sign utterances were scored as contextually consistent if they were used in previous high arousal interactions which were not part of the current study. Individual chimpanzee differences in signing frequency, emphatic modulation, and recipient allocation were found. Similar to humans, the chimpanzees’ verbal communication is a robust phenomena which continues to occur even during high arousal interactions.
Graft-versus-myeloma

Whereas patients with multiple myeloma continue to relapse after autologous transplantation and are unlikely to be cured, the probability of progression is less after allogeneic transplantation and a proportion of patients may be cured. This is attributable to an immunologically mediated graft-versus-myeloma (GVM) effect which is akin to the well-known graft-versus-leukemia effect. The available clinical and experimental evidence strongly support the existence of GVM, but it is not known whether GVM is separable from graft-versus-host disease (GVHD) in practice. The best way to exploit GVM reactions is unclear, and the morbidity and mortality associated with GVHD undermine long-term survival. There is usually a time lag of a few weeks between immune intervention and disease response. There is a propensity for extramedullary disease recurrence in patients whose marrow disease is controlled with immunologic manipulation. Exploration of GVM outside conventional allogeneic transplantation or after autologous transplantation is necessary to increase the number of patients likely to benefit from this phenomenon and to make it safer. This article reviews the currently available literature on the subject.
Construction and expression of a single-chain Fv antibody fragment against acidic isoferritin in Escherichia coli

Objective To obtain the functional single chain Fv antibody (scFv) against acidic isoferritin (AIF). Methods The variable regions of heavy chain (V_H) and light chain (V_L) from the hybridoma 4c9 were connected with a flexible linker using an assembly polymerase chain reaction. The construction of V_H-linker-V_L was inserted into a phagemid pCANTAB 5 E, and then selected with the recombinant phage antibody system (RPAS). Anti-AIF scFv gene from the recombinant phagemid pCAN4c9 was subcloned into pET28a and expressed in E. coli BL21(DE3). The recombinant anti-AIF scFv was characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Western blotting, and enzyme-linked immunosorbent assay after refold with an on-column refolding procedure based on Ni-chelating chromatography. Results The active anti-AIF scFv was recovered efficiently from inclusion bodies with a refolding yield of approximate 75% confirmed by spectrophotometer. The results showed that the anti-AIF scFv retained the specific binding activity to AIF with an affinity constant of 7.29× 10 -8 mol/L. The overall yield of anti-AIF scFv with bioactivity in E. coli flask culture was more than 62 mg/L. Conclusion A functional scFv antibody fragment specific against AIF is produced at high level in Escherichia coli.
A Simple Bioassay Method for Screening Pathogenic Fungi to Weeds

Alternaria alternata, Curvularia lunata, Helminthosporium gramineum Rabenh f. sp. echinochloae and Exserohilum monoceras are pathogenic fungi of barnyardgrass (Echinochloa crus-galli). Germinated seeds (coleoptile and radicle just emerged) of barnyardgrass and rice were directly inoculated on colonies of the pathogenic fungi cultured on PDA plates. Infection and growth inhibition of barnyardgrass and rice seedlings were investigated after culturing for several days. Results showed that the pathogenicity and growth inhibition of barnyardgrass by the four pathogens were almost the same with the results of normal test. Comparing to the normal test, the bioassay can save half time and reduce workload for testing and screening.
Mechanisms of hemostasis : effect on intracerebral hemorrhage

Aspects of the mechanisms of hemostasis are reviewed with particular emphasis on the assembly of enzyme complexes on the membranes of cells. The way this membrane fixation of reactions accelerates coagulation, inhibition, and fibrinolytic systems is discussed. The complex nature of the hemostatic system and the multiple complications of its abnormalities present a difficult problem for the neurologist and neurosurgeon managing the patient with intracerebral hemorrhage. This is a situation in which close consultation and collaboration among the neurological and hematologic specialists are imperative to achieve the most favorable outcome for the patient with this life-threatening situation
Interim report of a study of danazol for the treatment of endometriosis

Ninety-six infertile women with laparoscopically confirmed endometriosis received danazol (800mg daily) for 6 months. Despite their prevalence, side effects generally were tolerable and did not contraindicate use of the drug. The mean resolution of peritoneal endometriosis, measured in 44 patients, was 63%. However, individual responses varied considerably. The mean resolution of ovarian endometriosis in 28 patients was 45%. Resolution of less than 1cm involvement (57%) was similar to that of peritoneal endometriosis, but for more extensive ovarian disease it was only 37% to 40%. Preoperative use of danazol facilitated surgical removal of disease and probably reduced the risk of postoperative adhesions. Pregnancy rates, though reported, are not analyzed because of the brevity of follow-up to date.
Adults aging 'with' and 'into' paralysis: Epidemiological analyses of demography and health.

Abstract Background Survival for many individuals with paralysis is increasing, making this population a larger subset of the aging population (Molton, & Jensen, 2010). Yet little is known about the demographics and health of this population (Freedman, 2014). Objective This study is one of the first evaluations of the differences in etiology, sociodemographic and health characteristics (i.e., health status, chronic, and secondary and medical conditions) of adults aging with versus into disability. Methods A cross sectional epidemiological study was performed using secondary data from a nationally representative sample of adults with paralysis. The National Paralysis Survey is a random digit-dial survey of over 70,000 households. Weighted descriptive and regression analyses were conducted. Results Eighty percent of those aging with paralysis had disabilities for 40+ years. They showed significantly better self-reported health status, and a trend for more secondary and medical conditions. Those aging into paralysis had more chronic diseases. Conclusions Differences are evident between those aging with vs. into paralysis. These findings suggest that differentiating subgroups of older adults with disabilities by onset of disability makes disability and health information more actionable for programs and policies. Additional studies to explore the intersection of aging and disability onset across adulthood could increase our understanding of the dynamics of aging in persons with early and later onset disabilities.
The Universal and the Particular in the Constitution of Value

Recall Marx’s observation from ‘The Value-form’: ‘This inversion, whereby the sensate-concrete counts only as the form of appearance of the abstract-universal, and not, on the contrary, the abstract-universal as a property of the concrete, characterizes the value-expression.’ In order to begin to grasp how the dealist connotation of Hegelian formulae gets expelled through their usage by Marx, we have only to pay attention to the manner in which Marx’s ‘mode of expression’ here in fact departs from Hegel’s. For the topic of Marx’s claim is explicitly not the sensate-concrete as such, but only the latter inasmuch as brought ‘within the value-relation’. Now, what Marx calls the ‘value-relation’ is, in effect, just the ratio at which different categories of marketable goods exchange: so many units of one good being regularly obtainable for so many units of another.
Transcriptome Sequencing Reveals Thousands of Novel Long Non-Coding RNAs in B-Cell Lymphoma

Abstract Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of lymphoma. Roughly 40% of patients do not respond or relapse after current therapy. Gene expression profiling of DLBCL has revealed broad gene expression deregulation compared to normal B Cells and categorized DLBCLs into two main subtypes: germinal center B-cell like and activated B-cell like (GCB-DLBCL and ABC-DLBCL), both associated with distinct clinical outcomes. Recent RNAseq studies have demonstrated that large portion of the genome consists of long non-coding transcripts (lncRNAs) that exhibit cell type specific expression patterns and are shown to play critical roles in disease specific epigenetic gene regulation. We sought to discover and characterize novel lncRNAs expressed in DLBCL that are responsible for the disease phenotypes. We performed a systematic de novo lncRNA discovery analysis on RNAseq data obtained from 116 primary DLBCL tumors (dbGaP, phs000235.v6.p1), and 8 normal B-cell counterparts (4 Naive B-cell and 4 Germinal Center B-cell samples). We identified 2,632 novel expressed lncRNAs in DLBCL. These novel lncRNAs exhibit characteristics similar to known lncRNAs, such as low coding potential, > 200 nt in length, and exon counts (>=2 exons). Further comparison between tumors and normal B-cells revealed that 942 lncRNAs were expressed in DLBCL only. We noticed that many of these lncRNAs were located nearby coding-genes that are important in B-cell biology, such as BCL6, IKZF1, IL10, IRF4, PRDM1, TNFAIP3, etc. Indeed, using a computational tool GREAT, we found that the coding-genes located nearby DLBCL-specific lncRNAs were significantly enriched in immune cell activation and differentiation pathways (FDR To understand the regulation of lncRNA expression in DLBCL, we examined the histone mark profiles at lncRNA loci. First, we found in any given DLBCL cell line, there was a significant overlap of lncRNA promoters and H3K4me3 peaks (p Finally, we performed single nucleotide variant analysis on these novel lncRNAs by using VarScan. We identified 9,713 SNVs within the exonic regions of these lncRNAs. We calculated the Minimum Free Energy Scores (MFEs) by using RNAfold to examine whether these SNVs would have an impact on the stability of the lncRNA secondary structure. We observed a significantly higher than background shift towards the stabilization of the secondary structure with the SNVs (p Disclosures Melnick: ROCHE: Other: Research; Genentech: Speakers Bureau; Janssen: Other: Research; Celgene: Consultancy; Eli Lilly: Consultancy; Epizyme: Consultancy.
Perceptions of Racial Inequality in America

Chapter 6 presents a review of research examining inequality perceptions, framed by the previously described Disparities-Focused Model. Available evidence suggests that Whites dramatically underestimate the extent of present-day racial inequalities, and are also typically ignorant regarding the mechanisms that foster inequality—beliefs that predict support for racial colorblindness, as well as opposition to progressive racial policies. In addition to evidence suggesting that Whites’ inequality perceptions are largely inaccurate, factors that moderate inequality perceptions are also considered.
Smith and Critical groups of Polar Graphs

Abstract We compute the elementary divisors of the adjacency and Laplacian matrices of families of polar graphs. These graphs have as vertices the isotropic one-dimensional subspaces of finite vector spaces with respect to non-degenerate forms, with adjacency given by orthogonality.
Role of immune microenvironment in gastrointestinal stromal tumours.

Aims The immune microenvironment is a prognostic factor for various malignancies. The significance of key players of this immune microenvironment, including tumour-infiltrating lymphocytes (TILs) and expression of programmed death-ligand 1 (PD-L1), indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase (WARS) in gastrointestinal stromal tumours (GISTs) is largely unknown. Methods and results Tissue microarrays were constructed from pathology files, 1996-2016. Immunohistochemistry for PD-L1, IDO and WARS was correlated with tumour size, mitoses and outcomes. TILs expressing CD3, CD4, CD8, FoxP3 and GBP5 were counted. A total of 129 GISTs were analysed. Mean patient age was 62.5 years; 52.0% were male. Tumour location included 89 stomach (69.0%), 33 small bowel (25.6%) and seven other (5.4%). Mean tumour size was 5.6 cm; mean mitoses were 7.2 per 50 high-power field. Nineteen patients (15.0%) developed disease progression, to abdominal wall (n = 8), liver (n = 6) and elsewhere (n = 5). Median progression-free survival was 56.6 months; five patients died of disease. PD-L1 was positive in 88 of 127 tumour samples (69.0%), 114 of 127 tumours were IDO-positive (89.8%) and 60 of 127 were positive for WARS (47.2%). PD-L1 was associated with increased size (P = 0.01), necrosis (P = 0.018) and mitoses (P = 0.006). Disease progression was not associated with PD-L1 (P = 0.44), IDO (P = 0.14) or WARS (P = 0.36) expression. PD-L1-positive GISTs with CD8+ or CD3+ TILs were significantly smaller than tumours with CD8+ or CD3+ TILs. Conclusions PD-L1 expression was associated with increased size and mitoses. High CD8+ or CD3+ TIL counts were associated with decreased PD-L1/IDO+ GIST size. PD-L1 and IDO could be significant in GIST tumour biology, which invites consideration of immunotherapy as a potential treatment option.
Open-source parametric 3-D printed slot die system for thin film semiconductor processing

Abstract Slot die coating is growing in popularity because it is a low operational cost and easily scaled processing technique for depositing thin and uniform films rapidly, while minimizing material waste. The complex inner geometry of conventional slot dies require expensive machining that limits accessibility and experimentation. In order to overcome these issues this study follows an open hardware approach, which uses an open source 3-D printer to both fabricate the slot die and then to functionalize a 3-D slot die printing system. Polymer materials are tested and selected for compatibility with common solvents and used to fabricate a custom slot die head. This slot die is then integrated into a 3-D printer augmented with a syringe pump to form an additive manufacturing platform for thin film semiconductor devices. The full design of the slot die system is disclosed here using an open source license including software and operational protocols. This study demonstrates that functional lab-grade slot dies may be 3-D printed using low-cost open source hardware methods A case study using NiO2 found an RMS value 0.486 nm, thickness of 17–49 nm, and a maximum optical transmission of 99.1%, which shows this additive manufacturing approach to slot die depositions as well of fabrication is capable of producing viable layers of advanced electronic materials. Using this method, a cost savings of over 17,000% was obtained when compared to commercial slot die systems for laboratories.
The early signaling pathway of live yeast cell derivative in THP-1 monocytes.

Abstract Live yeast cell derivative (LYCD) is a medicinal yeast extract that has been used in the treatment of burns, wounds and hemorrhoids for over 70 years. It has been shown to enhance the closure of skin wounds in diabetic mice by increasing inflammation, angiogenesis, formation of granulation tissue and epithelial migration. An active fraction of LYCD has been identified as a mixture of peptides ranging in size from 5 kDA to 17 kDA. Despite its widespread use over many years, understanding of the mechanism by which LYCD acts to effect tissue repair responses is very limited. In this study, we have used a human monocyte-derived cell line, THP-1, as a representative of the inflammatory component of the wound healing process. We have identified two of the earliest responses to LYCD as an increase in cytoplasmic free calcium ([Ca2+]i) and the transcripts for c-fos. We have found that the increase in [Ca2+]i is both necessary and sufficient to account for the LYCD-induced elevation of c-fos. Furthermore, we have shown that the signaling pathway by which LYCD elevates [Ca2+]i involves both mobilization of Ca2+ from intracellular stores and influx of Ca2+ from the extracellular medium. Mobilization of store Ca2+ occurs first via activation of phospholipase C and this is followed by influx through activation of store operated calcium channels. These results constitute the first delineation of the early steps of the LYCD signaling pathway.
Wi-Fi tracking : Fingerprinting attacks and counter-measures

The recent spread of everyday-carried Wi-Fi-enabled devices (smartphones, tablets and wearable devices) comes with a privacy threat to their owner, and to society as a whole. These devices continuously emit signals which can be captured by a passive attacker using cheap hardware and basic knowledge. These signals contain a unique identifier, called the MAC address. To mitigate the threat, device vendors are currently deploying a countermeasure on new devices: MAC address randomization. Unfortunately, we show that this mitigation, in its current state, is insufficient to prevent tracking. To do so, we introduce several attacks, based on the content and the timing of emitted signals. In complement, we study implementations of MAC address randomization in some recent devices, and find a number of shortcomings limiting the efficiency of these implementations at preventing device tracking. At the same time, we perform two real-world studies. The first one considers the development of actors exploiting this issue to install Wi-Fi tracking systems. We list some real-world installations and discuss their various aspects, including regulation, privacy implications, consent and public acceptance. The second one deals with the spread of MAC address randomization in the devices population. Finally, we present two tools: an experimental Wi-Fi tracking system for testing and public awareness raising purpose, and a tool estimating the uniqueness of a device based on the content of its emitted signals even if the identifier is randomized.
Cardiovascular disease-related chronic conditions among Veterans Affairs colorectal cancer survivors: A matched case-control analysis.

4Background: The growing number of colorectal cancer (CRC) survivors often have multiple chronic conditions. Comparing CRC survivors and matched non-cancer controls, our objectives were to determin...
Measurement of a phonon-polariton dispersion curve by varying the excitation wavelength

Coupling between optical phonons and light leads to the formation of phonon polaritons, resulting in important changes to the material dispersion. Commonly, the phonon-polariton dispersion curve has been determined by transient-grating impulsive stimulated Raman-scattering measurements, but reported results for the prototypical dispersion curve of $\mathrm{LiNb}{\mathrm{O}}_{3}$ have led to some controversy. We present a procedure to measure the phonon-polariton dispersion curve by varying the pump wavelength with fixed probe wavelength that allows measurement over a broad range of wave vectors. We determine the lowest-frequency $E$-mode phonon-polariton dispersion curve for $\mathrm{LiNb}{\mathrm{O}}_{3}$ with measured wave vectors ranging from $1\ifmmode\times\else\texttimes\fi{}{10}^{3}\phantom{\rule{0.16em}{0ex}}\mathrm{c}{\mathrm{m}}^{\ensuremath{-}1}$ to $19\ifmmode\times\else\texttimes\fi{}{10}^{3}\phantom{\rule{0.16em}{0ex}}\mathrm{c}{\mathrm{m}}^{\ensuremath{-}1}$, which is the broadest known optically measured phonon-polariton dispersion curve for $\mathrm{LiNb}{\mathrm{O}}_{3}$. The broad range offers improved understanding of the extracted material parameters. We also note some challenges that occur in interpreting the data at short pump wavelengths; these effects help explain controversial differences between previous transient-grating measurements of $\mathrm{LiNb}{\mathrm{O}}_{3}$ dispersion curves.
A seven year laboratory and clinical experience with lithium carbonate as an adjuvant to cancer chemotherapy.

Early studies of lithium treated patients suggested that ingestion of this drug causes granulocytosis (Shopsin et al., 1971; Murphy et ah, 1971). Later, both in vitro granulocyte culture (Tisman et al., 1973) and in vivo granulocyte pool measurements (Stein et al., 1977; Rothstein et al., 1978) demonstrated that the lithium associated granulocytosis was most likely due to an increase in granulocyte production. Most cancer patients undergoing combination chemotherapy will eventually experience drug limiting, and in some, life-threatening leukopenia and it was postulated that lithium carbonate ingestion might help as an adjuvant in the treatment of patients receiving myelosuppressive chemotherapy.
Ergovaline Binding and Activation of D2 Dopamine Receptors in GH4ZR7 Cells

ABSTRACT Ergovaline inhibition of radioligand binding to the D2 dopamine receptor and ergot alkaloid inhibition of vasoactive intestinal peptide (VIP)-stimulated cyclic AMP production in GH4ZR7 cells, stably transfected with a rat D2 dopamine receptor, were evaluated. Ergovaline inhibition of the binding of the D2-specific radioligand, l3H1YM- 09151-2, exhibited a K1 (inhibition constant) of 6.9 f 2.6 nM, whereas dopamine was much less potent (370 k 160 nM). Ergot alkaloids were also effective in inhibiting VIP-stimulated cyclic AMP production, with EC50 values for ergovaline, ergonovine, cr-ergocryp- tine, ergotamine, and dopamine of 8 f 2,47 f 2, 28 _+ 2, 2 k 1, and 8 +_ 1 nM, respectively. Inhibition of cyclic AMP production by ergovaline was blocked by the dopamine receptor antagonist, ( -)-sulpiride (IC50, 300 f 150 nM). Our results indicate that ergot compounds, especially ergovaline, bind to D2 dopa- mine receptors and elicit second messenger responses similar to that of dopamine. These findings suggest that some of the deleterious effects of consumption of endophyte-infected tall fescue, which contains several ergot alkaloids including ergovaline, may be due to D2 dopamine receptor activation. Key Words: Ergot Alkaloids, Cell Cultures, Dopamine, Receptors, C-AMP, Binding
Clinical oncologic applications of PET/MRI: a new horizon

Positron emission tomography/magnetic resonance imaging (PET/MRI) leverages the high soft-tissue contrast and the functional sequences of MR with the molecular information of PET in one single, hybrid imaging technology. This technology, which was recently introduced into the clinical arena in a few medical centers worldwide, provides information about tumor biology and microenvironment. Studies on indirect PET/MRI (use of positron emission tomography/computed tomography (PET/CT) images software fused with MRI images) have already generated interesting preliminary data to pave the ground for potential applications of PET/MRI. These initial data convey that PET/MRI is promising in neuro-oncology and head & neck cancer applications as well as neoplasms in the abdomen and pelvis. The pediatric and young adult oncology population requiring frequent follow-up studies as well as pregnant woman might benefit from PET/MRI due to its lower ionizing radiation dose. The indication and planning of therapeutic interventions and specifically radiation therapy in individual patients could be and to a certain extent are already facilitated by performing PET/MRI. The objective of this article is to discuss potential clinical oncology indications of PET/MRI.
Ureaplasma Urealyticum and Human Infertility: The Effect of Antibiotic Therapy on Semen Quality *

Semen characteristics were evaluated in 64 men visiting our infertility clinic before and after the eradication of genital infection with Ureaplasma urealyticum. Semen quality was also analyzed in 9 men who were unsuccessfully treated for genital Ureaplasma infection, 11 men who had negative cultures and received no treatment, and 11 men who had negative cultures but received empirical antibiotic therapy. A significant improvement in spermatozoal motility (both the speed of forward progression and the percentage of motile cells) was found in the group that was successfully treated for Ureaplasma infection. Improvements were not demonstrated in any of the other patient groups. A correlation was found between improved motility and a decrease in certain abnormal features of seminal cytology that appear to be associated with Ureaplasma genital infection.
Apparent dissociation of photoperiodic time measurement between vernal migration and breeding under dim green light conditions in Gambel’s white-crowned sparrow Zonotrichia leucophrys gambelii

In seasonally breeding birds, the annual cycle of photoperiod is a principal environmental cue for temporal arrangement of different life-history stages, such as migration and breeding. In the past, most research has focused on the mechanisms of photoperiodic control of breeding with less attention paid to migration. In Gambel’s white-crowned sparrow Zonotrichia leucophrys gambelii (GWCS), photoreceptors for induction of breeding are known to reside in the basal hypothalamus. However, it is unknown whether the sites of photoperiodic reception for vernal migration are the same as those for breeding. Therefore, we hypothesized that they may be controlled separately. In this study, we exposed photosensitive GWCSs to low-penetration green light (wavelength at 510 nm) under a regime of 1 lux during the day and <0.1 lux at night, and switched the photoperiodic conditions from short day (10 h daytime) to long day (18 h daytime). The results showed that the experimental birds developed traits associated with vernal migration including mass increase, fat deposition and migratory restlessness behavior when transferred from short day to long day green light cycles, while control birds maintained continuously on short day green light conditions did not express any migration related characteristics. Neither experimental nor control groups showed gonadal recrudescence under either green light cycles. In support of our hypothesis, we were able to apparently dissociate the photoperiodic responses regulating vernal migration and breeding, which suggests separate mechanisms of photoperiodic time measurement. Such distinct photoperiodic mechanisms may drive the fine-tuned temporal arrangement of the two life history stages.
Bi-material strip based temperature sensor design and optimization through thermo-mechanical multi-physics modeling

With the capability of additive manufacturing, complex structures are easily fabricated to achieve various design purposes. In this work, a bi-material strip temperature sensor with complex periodi...
Jean Améry. Entre la razón crítica y la desesperanza

This article examines the writings of Jean Amery (Austria, 1912-1978), an Auschwitz survivor who through fiction and self-referential essay explored the catastrophe of the contemporary world. The autobiographical elements in his work constitute the real matter that Amery turned into a “contemplative essay”. He did not believe in the therapeutic virtue of memory, but rather only in his own experience and resentment —as portrayed by Frantz Fanon— as the breaking points and promontories from which he could observe the most ill-fated events of the past.
Anti-dopaminergic medication related myopathy causing respiratory muscle weakness without neuroleptic malignant syndrome (P3.461)

Objective: We report a case of toxic myopathy with severe respiratory muscle weakness due to anti-dopaminergic medications. Background: Several studies report muscle toxicity related to anti-dopaminergic medications, with up to 10% of patients developing serum creatine kinase (CK) elevation. While CK elevation can be extreme in neuroleptic malignant syndrome, severe motor weakness has rarely been reported. Design/Methods: Case report Results: A 29-year-old man with history of obsessive compulsive disorder and Tourette’s syndrome presented to the hospital for worsening dyspnea. A year prior, after an increased risperidone dose from 0.5mg to 1mg daily, the patient developed severe proximal muscle weakness, including respiratory weakness, with an elevated CK of 5932 units/L. Electromyography revealed a myopathic process. Muscle biopsy showed many degenerating, vacuolated fibers with a histiocytic infiltrate and a few T-cells. After discontinuation of risperidone, the patient improved clinically over 2 months. He was then started on ziprasidone 40mg daily and 3 weeks later his weakness recurred. On admission to our intensive care unit, his CK was 3318 units/L. He required intubation for worsening respiratory function complicated by aspiration pneumonia. He had severe proximal muscle weakness, including neck flexion weakness, without muscle rigidity. Following multiple weaning failures due to ineffective cough, tracheotomy was performed. On day 2, ziprasidone was discontinued and prednisone 60mg daily started. Repeat muscle biopsy showed significant reduction in the severity and extent of pathologic changes and prominent regenerative activity. Serum acid alpha-glucosidase activity was normal ruling out Pompe disease. He gradually improved, and at follow-up clinic visit 2 months after discontinuation of ziprasidone his CK was 62units/L and he was successfully decannulated. Conclusions: Toxic myopathy with proximal and respiratory muscle weakness can occur due to anti-dopaminergic medications, even in the absence of neuroleptic malignant syndrome. Identification and avoidance of the offending medication can lead to recovery. Disclosure: Dr. Harada has nothing to disclose. Dr. Gokden has nothing to disclose. Dr. Virmani has nothing to disclose. Dr. Stefans has nothing to disclose.
The Effect of Improving Basic Preventive Measures in the Perioperative Arena on Staphylococcus aureus Transmission and Surgical Site Infections: A Randomized Clinical Trial.

Importance Surgical site infections increase patient morbidity and health care costs. The Centers for Disease Control and Prevention emphasize improved basic preventive measures to reduce bacterial transmission and infections among patients undergoing surgery. Objective To assess whether improved basic preventive measures can reduce perioperativeStaphylococcus aureustransmission and surgical site infections. Design, Setting, and Participants This randomized clinical trial was conducted from September 20, 2018, to September 20, 2019, among 19 surgeons and their 236 associated patients at a major academic medical center with a 60-day follow-up period. Participants were a random sample of adult patients undergoing orthopedic total joint, orthopedic spine, oncologic gynecological, thoracic, general, colorectal, open vascular, plastic, or open urological surgery requiring general or regional anesthesia. Surgeons and their associated patients were randomized 1:1 via a random number generator to treatment group or to usual care. Observers were masked to patient groupings during assessment of outcome measures. Interventions Sustained improvements in perioperative hand hygiene, vascular care, environmental cleaning, and patient decolonization efforts. Main Outcomes and Measures PerioperativeS aureustransmission assessed by the number of isolates transmitted and the incidence of transmission among patient care units (primary) and the incidence of surgical site infections (secondary). Results Of 236 patients (156 [66.1%] women; mean [SD] age, 57 [15] years), 106 (44.9%) and 130 (55.1%) were allocated to the treatment and control groups, respectively, received the intended treatment, and were analyzed for the primary outcome. Compared with the control group, the treatment group had a reduced mean (SD) number of transmitted perioperativeS aureusisolates (1.25 [2.11] vs 0.47 [1.13];P = .002). Treatment reduced the incidence ofS aureustransmission (incidence risk ratio; 0.56; 95% CI, 0.37-0.86;P = .008; with robust variance clustering by surgeon: 95% CI, 0.42-0.76;P Conclusions and Relevance Improved basic preventive measures in the perioperative arena can reduceS aureustransmission and surgical site infections. Trial Registration ClinicalTrials.gov Identifier:NCT03638947
29.4 High-Performance Isolators and Notch Filters Based on N-Path Negative Transresistance

Negative-resistance circuits are used for a variety of functions, including the realization of oscillators and loss compensation. Active negative-resistance circuits, such as cross-coupled gm cells, can provide power gain but, when used for loss compensation, must be carefully designed to avoid oscillation. In addition, they present noise, linearity, and power-consumption challenges. In the recent past, linear periodically-time-varying (LPTV) circuits, typically implemented using switched capacitors, have shown unexpected yet highly desirable properties, including tunable high-Q bandpass/bandstop filtering [1] and non-magnetic nonreciprocity [2]. Here, we report a passive negative-transresistance (NTR) property of LPTV switched-capacitor circuits. This property is utilized in this work to realize (1) an N-path notch filter enhanced with reciprocal negative transresistance with ideally infinite depth regardless of the number of paths and (2) a non-magnetic non-reciprocal widely tunable N-path inductorless isolator with low loss and infinite isolation in the reverse direction.
Methadone for Opioid Use Treatment during Pregnancy: Trends in Postpartum Dose Adjustments.

Objective This study examines methadone dose adjustment postpartum. Methods A retrospective study of women with methadone for opioid use treatment (OUT) during pregnancy was performed. Patient charts were reviewed and data were extracted. Methadone doses from five temporal data points for each patient were used: starting dose, day of delivery, and 1, 2, and 6 months postpartum. Results Over 26 months, 49 pregnancies to women using methadone for OUT were evaluated and 20 (41%) were included. The mean methadone starting dose was 47 mg, compared with 86 mg at the time of delivery. The mean dose postpartum remained unchanged from delivery and 75% of pregnancies required the same dose or higher 1 month postpartum. By 2 months postpartum, only 33% were able to decrease their methadone dose. Twelve pregnancies completed follow-up until 6 months postpartum; only 17% of patients were able to decrease their dose, with an overall mean dose decrease was 12%. There was no difference between the mean dose at delivery and the 6-month postpartum dose. Conclusion Patients using methadone for OUT during pregnancy achieved minimal dose decreases postpartum. Patients should be counseled that postpartum dose tapers may be challenging and about alternatives to methadone for OUT.
Context-Dependent Implicit Authentication for Wearable Device Users

As market wearables are becoming popular with a range of services, including making financial transactions, accessing cars, etc. that they provide based on various private information of a user, security of this information is becoming very important. However, users are often flooded with PINs and passwords in this internet of things (IoT) world. Additionally, hard-biometric, such as facial or finger recognition, based authentications are not adaptable for market wearables due to their limited sensing and computation capabilities. Therefore, it is a time demand to develop a burden-free implicit authentication mechanism for wearables using the less-informative soft-biometric data that are easily obtainable from the market wearables. In this work, we present a context-dependent soft-biometric-based wearable authentication system utilizing the heart rate, gait, and breathing audio signals. From our detailed analysis, we find that a binary support vector machine (SVM) with radial basis function (RBF) kernel can achieve an average accuracy of 0.94 ± 0.07, F 1 score of 0.93 ± 0.08, an equal error rate (EER) of about 0.06 at a lower confidence threshold of 0.52, which shows the promise of this work.
Development of Competency in Needle-Guided Procedures Through the Use of Soft-Embalmed Cadavers

This study evaluated soft-embalmed human cadavers for ultrasound needle-guidance training. Second-year medical students used peripherally inserted central catheter (PICC) line and central line models and a Thiel-embalmed cadaver for training and provided feedback. Most (85%) agreed the cadaver was useful. There were positive correlations between performing the PICC line (r=0.44, P=.11) and central line (r=0.63, P=.03) procedures on a cadaver and in a clinical setting. Thiel-embalmed cadavers may provide important hands-on training.
A Single Center 8 Year Experience of Segmental Arterial Mediolysis Management

Abstract Objective : Segmental Arterial Mediolysis (SAM) is a rare, poorly understood vasculopathy that involves vacuolization of the arterial wall, most commonly of the visceral arteries. There are no established therapeutic or monitoring guidelines for SAM, and intervention typically depends on patient presentation. The purpose of this study is to review the management and outcomes of patients with this rare vascular disease Methods : Single center retrospective review of patients diagnosed with SAM between 2011 and 2019. Included were patients with radiological diagnosis of SAM. Demographic factors, past medical history, presenting symptoms, affected vessels, management, and lesion characteristics over time were collected. Demographic and periprocedural factors, and medical management strategies were compared for those who required operative intervention versus those managed non-operatively. Results : Thirty patients were included, 21 (70%) were male, mean age was 53.5 years (range: 35.7-72.2). Twenty-seven patients were managed non-operatively, 3 patients required surgical intervention. Patients who underwent operative intervention were more likely to present with pain >30 days (p Conclusions : Patients who underwent intervention for SAM presented with either mesenteric ischemia or pseudoaneurysm rupture. In patients that present without those conditions, medical management consisting of anti-hypertensives, antiplatelet agents, and lipid-lowering therapy was effective. Non operative management resulted in symptom resolution in all patients and surveillance imaging showed resolution of radiographic abnormalities in 6 patients out of 27 at less than one year.
Identification for utilization, not merely possession, of gifts: What matters is not gifts but rather deployment of gifts:

The focus of the field of giftedness is on the wrong thing. Instead of focusing on identifying who is gifted, the field should identify how people will deploy their gifts and educate students to de...
Coastal Ecosystem Vulnerability and Sea Level Rise (SLR) in South Florida: A Mangrove Transition Projection

We used static, elevation and land cover data to estimate sea level rise impacts (SLR) to urban, developed lands and coastal wetland systems in Everglades National Park and the East and West coastal regions in South Florida. Maps and data tables estimating potential state change to open water were compiled through overlay analysis of elevation, land cover, and SLR masks with future land cover projected using a land cover transition threshold model. Analysis was based on a 2- to 5-km-wide longitudinal band along the SW and SE coasts of Florida where sea-level rise has no surface impediments to inundation and will likely cause coastline transgression and wetland migration. Analysis used three different projections; 0.27 m (0.9 ft), 0.76 m (2.5 ft) and 1.13 m (3.7 ft) greater than current sea level by 2070 estimated by NOAA and IPCC. Under a 0.27 m SLR projection 51% of the coastal land cover may be impacted. Under 0.76 m and 1.13 m projected SLR, coastal land cover areas were impacted by 56.5% and 59.1%, respectively. Migration of coastal wetlands from their current location into more inland areas in response to increased water depths and as a function of empirically derived marsh and mangrove accretion rates were also evaluated. With a SLR of 0.76 m by 2070, without accretion, 1160 sq km of wetland became open estuarine water. However, with accretion values of 0.211 m (4.1 mm yr-1) and 0.55 m (11 mm yr-1) by 2070, there was a transition of wetland cover to open estuarine water of only 349 sq km and 41 sq km, respectively. Under a low SLR of 0.27 m by 2070 scenario with accretion, the coastal mangroves were able to migrate inland while maintaining the current coastline. It was only under the more extreme scenario of 1.13 m SLR by 2070 that accretion was not able to compensate for inundation and there was a loss of wetland coastline everywhere.