cssi/SciSciGPT-SciSciNet huggingface dataset:
Anticorrelated multidecadal variations between surface and subsurface tropical North Atlantic

[1] In this paper for the first time I show that the multidecadal variations of observed tropical North Atlantic (TNA) sea surface temperature (SST) are strongly anticorrelated with those of the observed TNA subsurface ocean temperature, with long-term trends removed. I further show that the anticorrelated change between the TNA surface and subsurface temperature is a distinctive signature of the Atlantic meridional overturning circulation (AMOC) variations, using water-hosing experiments with the GFDL state-of-art coupled climate model (CM2.1). External radiative forced simulations with the same model do not provide a significant relationship between the TNA surface and subsurface temperature variations. The observed detrended multidecadal TNA subsurface temperature anomaly may be taken as a proxy for the AMOC variability. Various mechanisms proposed for the multidecadal TNA SST variations, which are crucial for multidecadal variations of Atlantic hurricane activities, should take into account the observed anticorrelation between the TNA surface and subsurface temperature variations.
Respiratory morbidity and lung function in preterm infants of 32 to 36 weeks' gestational age

Normal lung development follows a series of orchestrated events. Premature birth interrupts normal in utero lung development, which results in significant alterations in lung function and physiology. Increasingly, there are reports documenting the broad range of complications experienced by infants aged 34 to 36 weeks' gestational age (GA). Our objective was to summarize the evidence demonstrating respiratory system vulnerability in infants aged 34 to 36 weeks' GA and to review the developmental and physiologic principles that underlie this vulnerability. A comprehensive search for studies that reported epidemiologic data and respiratory morbidity was conducted on the PubMed, Medline, Ovid Biosis, and Embase databases from 2000 to 2009 by using medical subject headings "morbidity in late preterm infants," "preterm infants and lung development," "prematurity and morbidity," and "prematurity and lung development." Because the number of studies exclusive to infants aged 34 to 36 weeks' GA was limited, selected studies also included infants aged 32 to 36 weeks' GA. Of the 24 studies identified, 16 were retrospective population-based cohort studies; 8 studies were observational. These studies consistently revealed that infants born at 32 to 36 weeks' GA, including infants of 34 to 36 weeks' GA, experience substantial respiratory morbidity compared with term infants. Levels of morbidity were, at times, comparable to those observed in very preterm infants. The developmental and physiologic mechanisms that underlie the increased morbidity rate and alterations in respiratory function are discussed. We also present evidence to demonstrate that the immaturity of the respiratory system of infants 34 to 36 weeks' GA at birth results in increased morbidity in infancy and leads to deficits in lung function that may persist into adulthood.
Factors determining pathogenicity of variants of ECHO 9 virus for newborn mice.

While some strains of ECHO 9 virus were found to be completely incapable of multiplying in newborn mice or even of being adsorbed by their tissues (e.g., the prototype Hill strain), other naturally occurring strains readily multiplied even after inoculation of as little as 3 TCD50 of virus. With the multiplying strains, the infection remained clinically inapparent except after inoculation of very large doses, usually in the range of 105 to 107.5 TCD50. Investigation of the question why such large doses were required to produce paralysis indicated that for paralysis to occur virus multiplication had to reach a level of 108 TCD50 or more within 4 days after inoculation of mice less than 1 day old. The reason for this was found in the fact that at 5 to 6 days of age the mice lost their susceptibility to paralysis even when multiplication was capable of progressing to the indicated high level. Thus, speed of multiplication and extent of muscle involvement before the 5th day of life were the determining factors. Passage in tissue culture had no effect except to yield a larger dose for inoculation, while serial propagation in mice resulted in a gradual enrichment of virus particles capable of more rapid multiplication in mice and in a concurrent greater paralytogenic activity of smaller doses.
Sequence specificity of streptozotocin-induced mutations

The isolation and characterization of streptozotocin (STZ)-induced mutations in the phage P22 mnt repressor gene is described. Cells carrying the plasmid-borne mnt gene were exposed to STZ to give 10-20 percent survival and at least an eleven-fold increase in mutation frequency. DNA sequence analysis showed that 50 of 51 STZ-induced mutations were GC to AT transitions, and one was an AT to GC transition. We have also compared the STZ mutational spectrum to that for N-methyl-N'-nitro-N-nitroso-guanidine (MNNG). There are sites in the mnt gene which are mutated only by STZ; only by MNNG, or by both agents. Sites at which only STZ induced GC to AT transition mutations occur were in sequences that are pyrimidine rich 5' to the mutated site and purine rich 3' to the mutated site. Induction of mutations by both STZ and MNNG should be considered to maximize the number of mutable sites.
Computational Investigations Evidencing Multiple Objectives in Portfolio Optimization

In this paper we argue for the recognition of criteria beyond risk and return in portfolio theory in finance. We discuss how multiple criteria are logical and demonstrate computational results consistent with the existence of multiple criteria in portfolio selection. With the efficient frontier becoming an efficient surface, the paper considers that what is the modern portfolio theory of today is best interpreted as a projection onto two-space of the real multiple criteria portfolio selection problem in higher dimensional space.
Exploring the Potential of Realtime Haptic Feedback during Social Interactions

We explore the use of haptic feedback to deliver supportive information during social interactions in realtime. In an exploratory user study, we investigated perceptual limitations of vibration patterns during a conversation between peers. The results from this study have then been used to develop a system for providing users with realtime information regarding the quality of their nonverbal behaviour while engaged in a public speech.
Abstract B52: MicroRNAs and SEL1L gene regulation in human pancreatic ductal adenocarcinoma

Pancreas‐specific tumor suppressor gene SEL1L is downregulated at both the mRNA and protein levels in a significant proportion of human pancreatic ductal adenocarcinoma (PDAC) cases. We sought to use statistical methods to determine if one or more aberrantly upregulated microRNAs (miRNA) are responsible for the repression of SEL1L, which would help elucidate the role of specific miRNAs in PDAC. Based on published microRNAs microarray data and miRNA targets prediction resource, we initially identified seven miRNAs for our study which were reported to be upregulated in PDAC and potentially target SEL1L. Using real‐time PCR, we quantitatively assessed the expression levels of SEL1L mRNA and these miRNAs in 42 pairs of PDAC samples and matched normal adjacent tissues. Fisher9s Exact Test and Kruskal‐Wallis Test were applied to evaluate the correlation between SEL1L and the miRNAs. Our results showed that the expression of SEL1L mRNA inversely correlates with the expression of 3 miRNAs ( P P P = 0.002, respectively). As the number of these overexpressed miRNAs increase from 0 to 3, we observed progressively increasing downregulation of SEL1L ( P − trend = 0.001). Our findings suggest that the 3 miRNAs work cooperatively to repress SEL1L mRNA expression. These specific miRNAs may serve as useful biomarkers for PDAC. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B52.
Enzymatically Modified Low-Density Lipoprotein Promotes Foam Cell Formation in Smooth Muscle Cells via Macropinocytosis and Enhances Receptor-Mediated Uptake of Oxidized Low-Density Lipoprotein

Objective— Enzyme-modified low-density lipoprotein (ELDL) is present in human atherosclerotic lesions. Our objective is to understand the mechanisms of ELDL uptake and its effects on vascular smooth muscle cells (SMC). Approach and Results— Transformation of murine aortic SMCs into foam cells in response to ELDL was analyzed. ELDL, but not acetylated or oxidized LDL, was potent in inducing SMC foam cell formation. Inhibitors of macropinocytosis (LY294002, wortmannin, amiloride) attenuated ELDL uptake. In contrast, inhibitors of receptor-mediated endocytosis (dynasore, sucrose) and inhibitor of caveolae-/lipid raft–mediated endocytosis (filipin) had no effect on ELDL uptake in SMC, suggesting that macropinocytosis is the main mechanism of ELDL uptake by SMC. Receptor for advanced glycation end products (RAGE) is not obligatory for ELDL-induced SMC foam cell formation, but primes SMC for the uptake of oxidized LDL in a RAGE-dependent manner. ELDL increased intracellular reactive oxygen species, cytosolic calcium, and expression of lectin-like oxidized LDL receptor-1 in wild-type SMC but not in RAGE−/− SMC. The macropinocytotic uptake of ELDL is regulated predominantly by intracellular calcium because ELDL uptake was completely inhibited by pretreatment with the calcium channel inhibitor lacidipine in wild-type and RAGE−/− SMC. This is in contrast to pretreatment with PI3 kinase inhibitors which completely prevented ELDL uptake in RAGE−/− SMC, but only partially in wild-type SMC. Conclusion— ELDL is highly potent in inducing foam cells in murine SMC. ELDL endocytosis is mediated by calcium-dependent macropinocytosis. Priming SMC with ELDL enhances the uptake of oxidized LDL.
Promoting Caring: Mindfulness- and Compassion-Based Contemplative Training for Educators and Students

There is a growing need to develop and deliver programs in educational settings that support the social, emotional, and prosocial development of teachers and students. In recent years, researchers, educators, and contemplatives have worked to develop and adapt mindfulness- and compassion-based interventions for use in school settings. This chapter provides a theoretical overview of three such programs—Mindfulness-Based Stress Reduction (MBSR), Cognitively Based Compassion Training (CBCT), and Sustainable Compassion Training (SCT)—which have been implemented in educational contexts. It also provides a brief overview of the development and status of these programs to date as well as suggestions for further research and application.
Influence Analysis of Powdered Milk Increasing Sharply on the Development of Dairy Industry in China

In recent years, the milk powder of imported increased quickly, which had a negative pressure effect to China's dairy industry and dairy processing enterprises. The phenomenon is not conducive to long-term sustainable and healthy development of China's dairy industry. Through analysis, foreign milk powder production costs and selling prices are lower than domestic, domestic consumers lack confidence in our milk, the appreciation of the RMB exchange rate, decreased tariff rates, scarcity of resources, and so on. There are the main factors to cause the increase of milk powder imports. In this regard, our country should increase support, increase the production capacity of cows, achieve the dairy industry integration and the make good use of foreign market, so as to alleviate the impact on the domestic milk market.
Numerical Simulation of Electric Field Distribution ofInsulator Surface

Using finite element program ANSYS for simulation electromagnetic field,a threedimensional model of insulator was constructed.Based on this model,the effect of the length of conductive particle and the uneveness factor of flashover voltage was analyzed.The simulation result indicates that flashover voltage has a decrease tendency with increasing of particle length,electric field strength had a saturation tendency with increasing of particle length.The simulation results are consistent with experiments.
Mechanisms of fracture healing.

Bone is remarkable in that…it regenerates itself. In fact, it is the only tissue…except the liver with that regenerative capacity….The stages of healing in fracture callus recapitulate the spatial ...
Übung und Ermüdung

Wir haben nun jene Leistungsanderungen zu erortern, die auf bestimmten Betatigungsgebieten sowohl in positivem Sinne (als Ubung) wie in negativem (als Ermudung) auftreten. Auch bei diesen sind, wie uberall im Leben, aussere und innere Bedingungen in Konvergenz wirksam, aber die ausseren ubernehmen jetzt die Fuhrung.
The Lipid Composition and Ca Transport Function of Sarcoplasmic Reticulum(SR) Membranes during Development in Vivo and in Vitro

Lipids play an essential role in the structure and function of biological membranes. The concept that the lipid enviroment influences the activity of membrane bound enzymes is now generally accepted. The sarcoplasmic reticulum(SR) of skeletal muscle is an intracellular membranous system with an important physiological role in contraction and relaxation (Hasselbach, 1964; Martonosi, 1971). The Ca2+ transport and (Ca2+ + Mg2+)-ATPase activities which exhibit isolated SR preparations have been shown to be dependent on membrane phospholipids (Martonosi, 1968). An involvement of the fatty acid component of phospholipids in the functioning of the Ca2+ pump has also been suggested (Seiler et al., 1970; Seiler & Hasselbach, 1971). With the purpose of further exploring the relationships existing between lipids and other components of sarcoplasmic reticulum and its Ca transport function, changes in biochemical composition were correlated with variations in Ca2+ uptake during development of skeletal muscle in vivo and in vitro.
New ideas and their acceptance. As it has related to preservation of chordae tendinea and certain other discoveries

The significant benefits of preserving chordal-papillary muscle integrity in mitral valve replacement took some two decades to become widely accepted. Familiarity with history clearly tells us that this paradox between our dedication to "new ideas" on the one hand, and opposition to their acceptance on the other has existed for hundreds of years. Most "new ideas" have been surrounded by controversy and opposition before wide acceptance. Selected examples from history are cited beginning with Roger Bacon in the 13th century, and continuing with Galileo, Semmelweiss, Lister, and Forssmann. The author cites two notable examples from his personal experiences. They occurred during the development of open heart surgery, and another during the development of the rigid bileaflet cardiac prosthesis, now known as the St. Jude cardiac prosthesis. Some of the basic reasons for this inevitable opposition are: an innate skepticism over anything "new." Simplicity is often resented, as well as any need to change patterns of behavior/habits. Determination, persistence, stubbornness are the most important components for successful research. In addition, the successful innovator must learn to expect opposition and not be deterred by it, but rather must learn to take sustenance from it, and "learn to thrive upon opposition." In conclusion, these observations and suggestions are summarized in a satire on "The Seven Ages in the Evolution of an Idea--with particular reference to the critic."
Clustering-aware structure-constrained low-rank representation model for learning human action attributes

This paper addresses the problem of learning meaningful human action attributes from high-dimensional video sequences based on union-of-subspaces (UoS) model. The model hypothesizes that each action attribute is represented by a subspace. It puts forth an extension of existing low-rank representation (LRR), termed the clustering-aware structure-constrained low-rank representation (CS-LRR) model, for unsupervised learning of human action attributes. The proposed CS-LRR model overcomes the shortcomings of existing techniques by its ability to handle disjoint subspaces, and by performing optimal spectral clustering of the subspaces. An efficient linear alternating direction method (LADM) is developed to solve the CS-LRR optimization problem. A human action or activity is represented as a sequence of transitions from one action attribute to another and can be uniquely represented by a subspace transition vector. These subspace transition vectors are used for human action recognition. The effectiveness of the proposed model is demonstrated through experiments on two real-world datasets for action recognition.
Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults.

Patients with severe traumatic brain injury (TBI) frequently present with concomitant injuries that may cause secondary brain injury and impact outcomes. Animal models have been developed that combine contemporary models of TBI with a secondary neurologic insult such as hypoxia, shock, long bone fracture, and radiation exposure. Combined injury models may be particularly useful when modeling treatment strategies and in efforts to map basic research to a heterogeneous patient population. Here, we review these models and their collective contribution to the literature on TBI. In addition, we provide protocols and notes for two well-characterized models of TBI plus hemorrhagic shock. Language: en
A Comparison of X-Band Polarization Parameters with In Situ Microphysical Measurements in the Comma Head of Two Winter Cyclones

AbstractSince the advent of dual-polarization radar, methods of classifying hydrometeors by type from measured polarization variables have been developed. The deterministic approach of existing hydrometeor classification algorithms of assigning only one dominant habit to each radar sample volume does not properly consider the distribution of habits present in that volume, however. During the Profiling of Winter Storms field campaign, the “NSF/NCAR C-130” aircraft, equipped with in situ microphysical probes, made multiple passes through the comma heads of two cyclones as the Mobile Alabama X-band dual-polarization radar performed range–height indicator scans in the same plane as the C-130 flight track. On 14–15 February and 21–22 February 2010, 579 and 202 coincident data points, respectively, were identified when the plane was within 10 s (~1 km) of a radar gate. For all particles that occurred for times within different binned intervals of radar reflectivity ZHH and of differential reflectivity ZDR, the ...
Re-conceptualizing (environmental) sociology

Despite decades of activity, environmental sociology has not yet achieved its original goal of reorienting the discipline to account for human–ecosystem interdependence. Here, I review critical assessments of the status of efforts in sociology, and beyond, to understand and communicate about socio-environmental processes. I argue that meaningful advances in environmental sociology are not possible without a more fundamental re-conceptualization of sociology and its core. With reference to Norbert Elias’ work on relations among the sciences, I show that sociology’s disciplinary isolation has been a significant obstacle to advancement. Situating sociology and its subject matter among adjacent sciences and theirs reveals fundamental premises, suggests alternative core concepts, and forms the basis of a general theory of socio-environmental processes, all conspicuously absent to date. I provide an overview of the concepts and theory, offer a visual model to convey it, and conclude by suggesting possible impli...
Battery Life Extending Charging Strategy for Plug-in Hybrid Electric Vehicles and Battery Electric Vehicles*

Abstract This paper presents an optimal control based charging strategy for plug-in hybrid electric vehicles (PHEVs) and battery electric vehicles (BEVs). This work proposes a method to minimize battery capacity degradation incurred during charging by optimizing current profile. A semi-empirical battery aging model is adopted to quantify the capacity loss; a generic control-oriented vehicle cabin thermal model is developed to describe the battery surroundings taking into account solar radiation. Optimal control solution offered by Pontryagin’s Minimum Principle (PMP) is presented. Simulation-based results show that the benefit of this strategy in terms of decreasing battery aging is significant, when compared with the existing strategies, such as the widely accepted constant current constant voltage (CC-CV) protocol.
Pay rates for vets and medics.

IN response to a job advertisement published in Veterinary Record on February 4, 2017 (vol 180, p iv) for a Senior Clinical Research Fellowship in Infection at the University of Liverpool's Institute of Infection and Global Health, offering differing pay rates depending on whether the successful candidate had a veterinary or medical degree, a number of BVA members expressed concern to us. We contacted the Institute of Infection and Global Health to raise these concerns directly. Professor Tom Solomon, …
How Children with Mental Disabilities Affect Household Investment Decisions.

We analyze how children with mental disabilities influence parental portfolio allocation. We find that risky asset holding decreases among households with special needs children. However, conditional on participating in financial markets, households with special needs children invest a larger portion of their wealth in risky assets. As risky asset holding is a key component of wealth building, these findings have important implications for both policy and household wealth inequality.
Exploring instructional differences and school performance in high-poverty elementary schools

ABSTRACTIn the United States, federal funding under Title 1 is provided to schools to improve academic achievement for disadvantaged students. Many students attending schools eligible for Title 1 funding are from families in poverty and at risk for negative outcomes. Identifying instructional factors that mitigate this risk must be a priority for teachers and school administrators, especially in high-poverty schools. Active instruction that increases student engagement has long been identified as a critical element of academic achievement. The purpose of this study was to explore teachers' use of teacher behaviors representing active instruction (specifically, provision of opportunities to respond [OTR] and feedback) in 22 high- and low-performing Title 1 elementary schools. Results of multilevel modeling indicated that although school-level variance was limited, teachers varied in rates of group OTR and negative feedback across schools: teachers in high performing schools delivered higher rates of group ...
Identifying Trauma-Related and Mental Health Needs: The Implementation of Screening in California’s Child Welfare Systems

A central aspect of trauma-informed care in child welfare (CW) systems is the use of a trauma-informed screening process. This includes the use of a broadly administered measurement approach to assist professionals in identifying current trauma-related symptomology or a history of potentially traumatizing events. With a high prevalence of unmet mental health needs among CW-involved children, screening can be a crucial step as systems strive to identify children impacted by trauma. This paper offers a summary of CW screening approaches in county-administered CW systems across California. Through a web-administered survey, 46 county administrators reported on their screening practices and perceptions. Information about ages of children screened and screening tools used, perceptions of screening implementation priorities, degree of implementation and satisfaction with screening processes is provided. Several implementation considerations for future trauma-informed care efforts are offered including maintaining a focus on childhood trauma, closing the science-practice gap, and evaluating the state of the science.
Tisha B’Av, “Ghetto Day,” and producing “authentic” Jews at postwar Jewish summer camps

ABSTRACTThe postwar period brought sweeping changes for American Jews. Communal socioeconomic transitions and the aftermath of the Holocaust triggered intense anxieties among Jewish leaders regardi...
Supercharacter theories of semiextraspecial p-groups and Frobenius groups

Abstract In this paper, we describe all supercharacter theories of semiextraspecial p-groups and Frobenius groups. We first review the constructions which will classify these supercharacter theories. We then show that the supercharacter theories of these groups, as well as the more general Camina pairs, must have nontrivial C-normal subgroups. Next, we examine the superclass structure to show that the supercharacter theory can be constructed from supercharacter theories of subgroups of the group and its quotient groups. We can apply this to count the number of supercharacter theories for the group.
Dui yu lishi, kexuejia you hua shuo: 20 shiji Zhongguo kexuejie de ren yu shi 对于历史,科学家有话说:20世纪中国科学界的人与事 [Scientists Have Something to Say about History: The People and Issues of Twentieth-Century China’s Scientific World]

People in our profession frequently need to explain why we think historians have something to say about science. In this rich collection of oral histories, historian Xiong Weimin seeks to demonstra...
Higher Fungi in Tundra and Subalpine Tundra from the Yukon Territory and Alaska

Descriptions and illustrations are provided for six species of Inocybe and one Cortinarius collected in tundra and subalpine tundra mainly from the St. Elias Mountains, the Yukon Territory and Alaska. A new combination, Inocybe boltoni ssp. giacomi, is proposed.
ATTRACTING WHOM ? - MANAGING USER -GENERATED - CONTENT COMMUNITIES FOR MONETIZATION

Successful monetization of user-generated-content (UGC) business calls for attracting enough users, and the right users. The defining characteristic of UGC is users are also content contributors. In this study, we analyze the impact of a UGC firm’s quality control decision on user community composition. We model two UGC firms in competition, with one permitting only high quality content while the other not controlling quality. Users differ in their valuations and the content quality they contribute. Through analyzing various equilibrium situations, we find that higher reward value generally benefits the firm without quality control. However, when the intrinsic value of contribution is low, higher reward value may surprisingly drive high valuation users away from that firm. Also somewhat interestingly, we find that higher cost of contribution may benefit the firm that does not control quality. Our work is among the first to study the business impact of quality control of UGC.
The effect of the Halothane and Rendement Napole genes on carcass and meat quality characteristics of pigs.

The objective of this study was to determine the effects of the Halothane (N) and Rendement Napole (RN) genes on carcass and meat quality characteristics in pigs. Halothane and RN carrier (Nn/RN- rn+) Hampshire boars (n = 4) were mated to dams that were homozygous for the normal allele of both genes (NN/rn+ rn+) to produce progeny of four genotypes: 1, NN/rn+ rn+ (n = 31); 2, Nn/rn+ rn+ (n = 27); 3, NN/RN- rn+) (n = 30); and 4, Nn/RN- rn+ (n = 23). A DNA test was used to determine Halothane genotype, and longissimus glycolytic potential was used to predict the RN genotype. Pigs were reared under standard conditions to approximately 120 kg live weight and slaughtered at a commercial plant, and carcass characteristics and meat quality were evaluated. Halothane carriers (Nn/ _ _), in comparison to Halothane normal (NN/_ _) pigs, had shorter carcasses, lower longissimus ultimate pH, higher Minolta L* and b* values, and greater drip loss. Rendement Napole gene carriers (_ _/RN- rn+) had higher L* and b* values and drip and cooking loss and lower longissimus ultimate pH than homozygous recessive animals (_ _/rn+ rn+). There were Halothane x RN genotype interactions (P 0.05) of gender on other meat quality traits. This study illustrates the negative effects of the Halothane and RN genes on fresh pork quality and suggests that in combination the detrimental effects of the two genes are additive for ultimate pH, objective color, and water-holding capacity.
The effect of spatial working memory capacity on ball flight perception

Batting in baseball or softball represents a physically and perceptually challenging task. Changes in flight of a high-speed pitched ball require quick and accurate predictions of future location. To be successful, an individual must be able to rapidly gather and process visual information, suggesting an emphasis on spatial working memory. The current experiment assessed if individuals of variant expertise levels (novices and varsity softball players) differed in ability to determine future locations of a pitched ball based on different pitch types and durations. Data suggest an impressive base capability for visual motion prediction including a time appropriate ability to predict motion timing. Additionally, while not central to this capability, data suggest a relevance for spatial working memory in predicting speed. These results demonstrate a need to further investigate a base ability in motion prediction as well as the impact of working memory in high performance skills.
What is a placental mammal anyway

Many developmental functions in marsupials and eutherian mammals are accomplished by different tissues, but similar genes.
Perineurioma of the Tongue: A Case Report and Review of the Literature

A perineurioma (PN) is a rare benign peripheral nerve sheath tumor derived from perineurial cells. Based on clinical and pathologic features, PNs can be classified into 2 major subtypes: intraneural PN (IPN) and the more common extraneural PN (EPN). EPNs and IPNs are extremely rare in the oral cavity, and there have been only 38 reported cases (21 EPNs, 17 IPNs). In the present case, a 20-year-old man presented with a painless left dorsal tongue mass. Excisional biopsy examination indicated a diagnosis of EPN based on microscopic examination with immunohistochemical analysis. Twenty-eight months later the patient presented again with concern for a recurrent lesion. Intraoral examination showed a firm nonulcerated left dorsal tongue mass. Re-excision and microscopic examination with immunohistochemical analysis confirmed the diagnosis of an EPN. This report presents an unusual case of EPN that arose in the tongue and potentially recurred, although the possibility of persistence versus true recurrence exists. In addition, the clinicopathologic characteristics of previously reported cases of oral PN are reviewed.
Modeling and Analysis of Marine Product Trade on the Coordinated Development of Economy and Resource in Border and Coastal Area

Chang, D., 2018. Modeling and analysis of marine product trade on the coordinated development of economy and resource in border and coastal area. In: Liu, Z.L. and Mi, C. (eds.), Advances in Sustainable Port and Ocean Engineering. Journal of Coastal Research, Special Issue No. 83, pp. 229–236. Coconut Creek (Florida), ISSN 0749-0208.Marine product trade has become an important driving force in international economic and trade exchange. The analysis of the relationship between marine product trade and border and coastal economic resource is of vital importance for promoting the economic development of coastal cities. The establishment of the coordinated development model of marine product trade and economy and resource of the border and coastal area can help improve the import and export volume of marine product. The research problem of traditional model is too simple, and the content of research is not deep enough. To address this problem, starting from the analysis of the effect mechanism of port economy on the development of coastal economy, based on the export orientation theory, agglomeration and diffusion effect, the dynamic process of marine product trade promoting economic development is analyzed. From the two aspects of theory and practice, it is revealed that there is a close relationship between marine product trade and economic development of the border and coastal area. The model is established by mathematical theory, and the feasibility of the model is verified by comparing with the traditional model. Experimental results show that the proposed model can quickly and effectively analyze the influence of s marine product trade on the coordinated development of economy and resource in the border and coastal area and promote the economic progress of the coastal cities.
Relationship of alternate bearing and apical bud development in cranberry (Vaccinium macrocarpon Ait.)

Similar to other woody crops, cranberry (Vaccinium macrocarpon Ait.) exhibits alternate bearing or a tendency to produce heavier yields one year, followed by lighter yields the next year. Unfortuna...
Two-layer Predictive Controller for V2G and G2V Services Using on Wireless Power Transfer Technology

This paper presents a comprehensive solution that allows electric vehicles (EV) to autonomously charge and discharge their batteries wirelessly during long term parking and/or the transient stops. A two-layer power-flow controller for bidirectional wireless power transfer system (BWPTS) in EVs applications is proposed. The proposed controller can manage the bidirectional power-flow between EV and surrounding infrastructures such as power grid, home microgrid, building micro-grid, road or another vehicle. It consists of two levels of control; the first is responsible for communicating with the surrounding infrastructures and gathering information from driver, charging station, power grid and battery management system and then, based on these information, it estimates the EV's psychological price as a function of its battery's state-of-charge (SOC) and compares it with the energy price to decide whether to charge, discharge or abstain, and how much the charging or discharging rate. The second layer receives the reference signal from the first one and generates the control parameters for two synchronized resonant converters (one is on the vehicle side and the other is on the grid side) to provide the requited power-flow. The proposed controller is adaptively estimating the system parameters to consider the misalignment conditions effects on the system performance. The parameter estimation is achieved using only one voltage sensor. The second layer control is designed based on a new analytical modeling for the power flow in the system. For verification purposes, a prototype for BWPTS was built and driven by the proposed controller, which was implemented using a field-programmable gate array (FPGA) integrated circuit. The proposed controller provides very fast and stable response during both the transient and steady state operation in comparison with the conventional PI controller.
Histologic findings associated with laser interstitial thermotherapy for glioblastoma multiforme.

Laser-interstitial thermal therapy (LITT) has been supported by some authors as an ablative treatment of glioblastoma multiforme (GBM). Although the effects of LITT have been modeled in vivo, the histologic effects in a clinical circumstance have not been described. We analyzed tissue from a patient who underwent LITT as primary treatment for GBM. A 62-year-old male was diagnosed with a left temporal GBM and underwent LITT at an outside institution. Despite corticosteroid therapy, the patient was referred with increasing headache and acalculia associated with progressive peritumoral edema two weeks after LITT procedure. En bloc resection of the enhancing lesion and adjacent temporal lobe was performed with steroid-independent symptom resolution (follow-up, > 2 years). Histologic analysis revealed three distinct histologic zones concentrically radiating from the center of the treatment site. An acellular central region of necrosis (Zone 1) was surrounded by a rim of granulation tissue with macrophages (CD68) (Zone 2; mean thickness, 1.3 ± 0.3 mm [±S.D.]). Viable tumor cells (identified by Ki-67, p53 and Olig2 immunohistochemistry) were found (Zone 3) immediately adjacent to granulation tissue. The histologic volume of thermal tissue ablation/granulation was consistent with preoperative (pre-resection) magnetic resonance (MR)-imaging. These findings are the first in vivo in humans to reveal that LITT causes a defined pattern of tissue necrosis, concentric destruction of tumor and tissue with viable tumor cells just beyond the zones of central necrosis and granulation. Furthermore, MR-imaging appears to be an accurate surrogate of tissue/tumor ablation in the early period (2 weeks) post-LITT treatment. Surgery is an effective strategy for patients with post-LITT swelling which does not respond to steroids.
Conspecifics, not pollen, reduce omnivore prey consumption

Pollen can decrease (via reduced consumption) or increase (via numerical response) an omnivores consumption of animal prey. Although pollen can increase predation pressure through numerical responses of omnivores, pollen may also suppress predation by increasing omnivore interactions with conspecifics. Despite this potential, studies of the impacts of pollen on predation by omnivores often overlook the effect of these tissues on intraspecific interactions between omnivores. We designed three studies to examine how Spartina foliosa pollen and conspecific density impact scale insect prey consumption by ladybeetle (Naemia seriata) omnivores. First, we assessed how pollen impacts scale insect consumption by isolated ladybeetles. Second, we measured how pollen influences ladybeetle prey suppression when numerical responses were possible. Third, because initial experiments suggested the consumption rates of individual ladybeetles depended on conspecific density, we compared per capita consumption rates of ladybeetles across ladybeetle density. Pollen did not influence prey consumption by isolated ladybeetles. When numerical responses were possible, pollen did not influence total predation on prey despite increasing ladybeetle density, suggesting that pollen decreased per capita prey consumption by ladybeetles. The discrepancy between these studies is likely a consequence of differences in ladybeetle density-the presence of only two other conspecifics decreased per capita prey consumption by 76%. Our findings suggest that pollen may not alter the population level effects of omnivores on prey when omnivore numerical responses are offset by reductions in per capita predation rate.
Oncology drug shortages in the USA - business as usual.

Shortages of drugs, including chemotherapeutics, are increasingly common in the USA, and compromise patient care, delay clinical trials and are associated with substantial financial costs. The recent shortage of vincristine, a chemotherapeutic used for most children with cancer and countless adult patients, presents a particularly vexing challenge. Drug shortages can cause patients unnecessary anxiety and challenge clinicians to ration lifesaving medications for which no alternative agent exists. We provide an overview of this problem and discuss potential solutions.
Radical hysterectomy is not associated with a survival benefit for patients with stage II endometrial carcinoma

Abstract Objective To evaluate the role of radical hysterectomy in the management of patients with stage II endometrial carcinoma. Materials Patients diagnosed between 2004 and 2015, with stage II (based on the revised FIGO staging) endometrial carcinoma who had hysterectomy and regional lymph node surgery were identified in the National Cancer Database. Those who had radical or modified radical (RH), or total hysterectomy (TH) were selected. Overall survival (OS) was assessed with Kaplan-Meier curves and compared with the log-rank test. A Cox model was constructed to evaluate survival after controlling for confounders. Results A total of 7552 patients who met the inclusion criteria were identified. Rate of RH was 10.5%. Those who underwent RH had longer hospital stay (median 3 vs 2 days, p Conclusions Radical hysterectomy was not associated with a survival benefit in a cohort of patients with stage II endometrial carcinoma.
An ultrathin integrated nanoelectromechanical transducer based on hafnium zirconium oxide

Nanomechanical resonators that can operate in the super high frequency (3–30 GHz) or the extremely high frequency (30–300 GHz) regime could be of use in the development of stable frequency references, wideband spectral processors and high-resolution resonant sensors. However, such operation requires the dimensions of the mechanical resonators to be reduced to tens of nanometres, and current devices typically rely on transducers, for which miniaturization and chip-scale integration are challenging. Here, we show that integrated nanoelectromechanical transducers can be created using 10-nm-thick ferroelectric hafnium zirconium oxide (Hf0.5Zr0.5O2) films. The transducers are integrated on silicon and aluminium nitride membranes, and can yield resonators with frequencies from 340 kHz to 13 GHz and frequency–quality-factor products of up to 3.97 × 1012. Using electrical and optical probes, we show that the electromechanical transduction behaviour of the Hf0.5Zr0.5O2 film is based on the electrostrictive effect, and highlight the role of nonlinear electromechanical scattering in the operation of the resonator. Nanomechanical resonators with frequencies from 340 kHz to 13 GHz can be created using an integrated 10-nm-thick transducer layer of hafnium zirconium oxide.
Cardiac transplant recipient with COVID-19 induced acute hypoxic respiratory failure: a case report

Background Heart transplant recipients represent a particularly vulnerable patient population to the novel coronavirus disease 2019 (COVID-19) due to chronic immunosuppression and high rates of comorbidities. Currently, data are limited and evidence to guide management of heart transplant recipients with COVID-19 is sparse. In this case report, we provide a summary of the current literature as well as an in-depth analysis of our clinical decision-making. Case summary A 67-year-old female who underwent cardiac transplantation 1 year prior was found to have acute hypoxic respiratory failure due to COVID-19. Her immunosuppressant medications were modulated with discontinuation of mycophenolate and titration of tacrolimus troughs with a goal of 6-10 ng/dL. She was administered supportive treatment including convalescent plasma, remdesivir, and dexamethasone, in addition to antibiotic treatment that resulted in resolution of her symptoms within a matter of days despite her precarious disposition. Discussion This case demonstrates that it can be safe and efficacious to modulate immunosuppressant medications in cardiac transplant recipients in accordance with recommendations made by the International Society of Heart and Lung Transplantation. This case additionally demonstrates that aspects of the current literature regarding the management of COVID-19 can be safely extrapolated to cardiac transplant recipients. Providing supportive care with dexamethasone, remdesivir, and convalescent plasma as indicated can be beneficial in cardiac transplant recipients; although, the current literature regarding convalescent plasma and remdesivir is conflicting.
Non-Riemannian Quantities

In this chapter, we will introduce several geometric quantities for sprays and Finsler metrics. These quantities always vanish for Riemannian spaces. Therefore, they are said to be non-Riemannian. The most important non-Riemannian quantity was introduced by L. Berwald [Bwl] [Bw2] [Bw8] for Finsler metrics. Who is L. Berwald?
Reduced-rank multiuser detectors based on vector and matrix conjugate gradient Wiener filters

Using the notion of expanding subspace and the framework of reduced-rank signal processing, we present our latest discovery on applying the vector and matrix conjugate gradient (CG) methods to design reduced-rank linear MMSE multiuser detectors (MUD) for code division multiple access (CDMA) systems. We show that for a synchronous CDMA system with K users, each using a distinct length N spreading code, the vector CG method converges to the full-rank linear MUD in at most K steps (K/spl les/N).The matrix CG method converges to the full-rank linear MUD in one step. Furthermore, when the Gold codes are used as spreading codes in combination with a groupwise power control scheme, early convergence in the vector CG Wiener filter can be reached in just L steps (L/spl Lt/K/spl les/N), typically L=2/spl sim/4 independent of the user number K and the spreading length N.
Comparison and analysis of energy consumption in typical Iowa swine finishing systems

Fossil fuel use in agriculture is an increasingly important topic of concern. Iowa is the largest swine producing state in the United States. A systems analysis was performed to evaluate energy use in deep bedded hoop and confinement swine finishing systems for typical Iowa conditions. Energy use for feed production, facility operation, bedding production, manure application, and swine management were analyzed and the use of onfarm versus offfarm feed processing was compared. Energy for feed required 68 to 82% of the overall energy use. The hoop system required an average of 3.6% less overall energy and 47% less non-feed energy than the confinement system. On-farm feed processing reduced the overall energy an average of 9.5% when compared to off-farm feed processing. 774 MJ of non-solar energy was required to produce 104.5 kg of gain for a pig raised in a deep bedded hoop system with on-farm feed processing while 879 MJ was required in a confinement system with off-farm feed processing. Development of low external input integrated cropping and swine production systems will be key to reducing energy use in swine finishing systems.
River of Tears: Country Music, Memory, and Modernity in Brazil

Reviewed Medium: book Authors: Alexander Sebastian Dent Year: 2009 Pages: 312 Publisher: Duke University Press ISBN: 978-0-8223-4520-6 (hard cover). Prices: $84.95 USD(hard cover).
Astrocyte origin of activity-dependent release of ATP and glutamate in hippocampal slices: real-time measurement utilizing microelectrode biosensors.

It is well known that astrocytic and neuronal transmitter release processes are important for signalling, and that activity-dependent release of adenosine nucleotides and transmitters occurs after stimulation. Neurons and astrocytes can account for the source of ATP efflux. In this issue of the BJP, Heinrich et al. characterized K+ depolarization-evoked release of ATP, adenosine and glutamate in hippocampal slices, utilizing microelectrode biosensors for simultaneous real-time recordings of multiple transmitter effluxes. They demonstrated efflux of ATP, adenosine and glutamate from hippocampus slices, in response to K+-depolarization, with distinct kinetics and mechanisms, suggesting a coordinated pattern of transmitter release. Surprisingly, it turned out that a considerable amount of the transmitter efflux measured under these conditions had a glial origin. For a long time, it was believed that the glial cell did not play a major role in neurotransmission, but the latter results somewhat change this view. The release of ATP and glutamate from glial cells under these conditions involved P2X7 receptors, and a source of adenosine accumulation independent of the metabolism of extracellular ATP was identified. This study also highlighted a novel use of multi-enzymatic microelectrode biosensors, which enabled a better characterization of transmitter release processes with higher temporal and spatial resolution than obtained previously. This technique was originally developed and used for the detection of purine release. In the present study, it was modified to identify the interplay between different transmitters, measured simultaneously in hippocampal slices. LINKED ARTICLE This article is a commentary on Heinrich et al., pp. 1003–1020 of this issue. To view this paper visit http://dx.doi.org/10.1111/j.1476-5381.2012.01932.x