cssi/SciSciGPT-SciSciNet huggingface dataset:
Myeloma Cell Interaction with Osteoclasts and Mesenchymal Stem Cells Reveals Genes Associated with Post Relapse Survival

Abstract 2957 Myeloma is intimately associated with osteolytic bone disease, resulting from myeloma cells9 interactions with osteoclasts and osteoblasts and their progenitors, and is dependent on the changes it induces in bone metabolism for progression. Myeloma cell dependence on the bone marrow microenvironment is also evident experimentally, where interaction of primary myeloma plasma cells (MMPC) with osteoclasts (OC) and with mesenchymal stem cells (MSC) support the survival of primary myeloma cells. To understand the molecular mechanisms associated with the survival of MMPC, we used Acuity 4 software to analyze Affymetrix U133 Plus2 chip data and identify changes in gene expression in induced MMPC freshly isolated from 8 patients by interaction with OC and from 8 additional patients with MSC. Expression by MMPC of 675 genes was changed following interaction with OC; 552 genes were upregulated and 123 down regulated. Expression of 296 genes was changed in MSC co cultures (161 upregulated, 135 down regulated). Comparison of the genes whose expression was similarly changed in both co culture systems identified 72 probesets, representing 58 genes, that were commonly changed; 33 were upregulated and 25 down regulated. Ingenuity Pathway Analysis assigned 54 of the 58 genes to 4 distinguished networks of interrelated genes with high probability scores. We next tested the hypothesis that the expression of genes whose expression was commonly changed in the co culture systems has clinical significance. To accomplish this, we used gene expression data available on 127 relapsed patients who had been uniformly treated on our Total Therapy 2 protocol, and for whom gene expression (GEP) data at first relapse (RL) were available. 71 of these patients also had pre treatment (BL) GEP data; for these 71 patients we calculated change in expression of the 72 probesets as the ratio of RL/BL expression signal. We identified 7 genes whose expression changes were significantly (p≤0.05) associated with survival after relapse: These genes were, in order of significance: CCNE2, PECAM1, KLHL21, ICAM1, PLAU, ANPEP, and DUSP1, with p-values ranging from 0.017 to 0.05. Up regulation of PECAM1, ANPEP, DUSP1, and down regulation of CCNE2, KLHL21, ICAM1, and PLAU were associated with longer survival. We further determined whether expression level of these 72 probesets at relapse, defined by signal intensity, correlated with post relapse survival of the 127 patients; 18 genes were significantly (p -7 , HR, defined as ratio of hazard for a twofold increased in signal) =1.83), PECAM1 (p=2e -7 , HR=0.64), FOSB (p=2.3e -6 , HR=0.76), HMOX1 (p=8.2e -5 ; HR=0.72), CISH (p Disclosures: No relevant conflicts of interest to declare.
Emotionality and Violent Behavior in Psychopaths

According to the classic clinical description of psychopathy offered by Hervey Cleckley, violence and persistent criminality are not essential aspects of the disorder. He theorized that the primary features of psychopathy derive from a constitutional deficit in affectivity that actually diminished the likelihood of intense emotional displays, vengeful grudges, and angry aggression.
Decreased pulmonary function in asymptomatic long-term survivors after allogeneic hematopoietic stem cell transplant.

Decreased pulmonary function in asymptomatic long-term survivors after allogeneic hematopoietic stem cell transplant
Concentration in Food Retailing

CONVENTIONAL criteria for evaluating economic concentration may no longer be useful in a dynamic world where economic growth is a prime economic goal. This paper argues that economic growth rather than competitive efficiency may be a more appropriate criterion by which concentration should be evaluated. A theory of concentration in food retailing is offered and developed conceptually and statistically with a newly devised index of concentration. The hypothesis holds that concentration in food retailing is a function of the level of economic development in a region; concentration is higher in rich than in poor regions and grows with the economic development of a region over time. The purpose here is not to demonstrate that concentration is good or bad. Rather, the objective is to provide a new criterion for evaluating concentration in food retailing by explaining why it varies systematically among regions and over time. This is a study in the anatomy rather than the physiology of food retailing [1]. We are concerned here with concentration and its causes rather than its effects. The dependent variable is a statistical concentration index which describes an array of retail food firms ordered by size; the independent variables represent forces which may cause concentration. A major premise of this paper is that the economic performance of an industry cannot adequately be appraised without first knowing why and how industry structure is determined. Part I examines some of the policy issues and theoretical implications of concentration in food retailing. Part II seeks theoretical causes of concentration and develops the hypothesis conceptually. Part III defines retail concentration and presents a new index for its measurement. Part IV tests the hypothesis statistically and Part V concludes the argument.
The interpretation of the Wadati diagram with relaxed assumptions

The usual interpretation of the graph of ( S-P ) versus P in terms of the ratio of P - and S -velocities ( α/β ) and the origin time is valid only if α/β is the same in all media along the wave path. The properties of the graph have been derived for the cases in which α/β differs in layers by amounts that are small but representative of the range found in crustal rocks. For data at regional distances large compared to the depth, the slope yields a good approximation to α/β in the lowest layer traversed by the waves. The P -axis intercept is no longer the origin time. For a hypocenter in a half-space overlain by one layer, the origin time error is approximately proportional to the difference in α/β in the two media. If the origin time is known independently, for example, from a location program with good data and a good velocity model, the error in origin time given by the Wadati diagram can be used to verify the model. The technique was applied to a tightly clustered group of earthquakes well-placed with respect to the network centered on Amchitka Island. The P -velocities were well-determined, but Poisson's ratio had been arbitrarily taken as 0.25. The results called for a decrease of σ to 0.24 in the source layer (10.2-22.6 km) and an increase to 0.28 in the material above. The premonitory decrease in α/β proposed as a predictive phenomenon by Semyenov was marginally detected for one event during the 12 months following April, 1971. Conditions in an island arc make the application of the technique difficult. The time duration of the minimum relative to the magnitude of the earthquake agrees well with the results of other investigations.
Abstract 2143: Smg-GDS regulates cellular proliferation in squamous cell carcinomas of the head and neck

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Squamous cell carcinoma of the head and neck (SCCHN) is a major worldwide source of morbidity and mortality, with over 26,000 estimated new cases and 6,000 deaths from pharyngeal and laryngeal cancer in 2011 in the the United States alone. SCCHN is an aggressive disease which is characterized by local invasion and lymphatic and distant metastasis. Ras and Rho family GTPases are known to regulate tumor cell proliferation in numerous human cancers including SCCHN. SmgGDS, an unusual guanine nucleotide exchange factor, has previously been shown in other systems to activate these small GTPases and directly regulate cellular proliferation through control of small GTPase prenylation and cellular localization. Little is known about the role of SmgGDS in the progression of SCCHN. These studies were begun to characterize the expression of SmgGDS in SCCHN and assess the role that SmgGDS plays in SCCHN proliferation. SCCHN tumor tissue microarray analysis demonstrated increased SmgGDS expression in tumor tissue from various head and neck sites compared to normal tissues, with evidence for higher SmgGDS expression at the pushing tumor boarders in invasive cancers. Significantly increased amounts of SmgGDS protein and RNA expression were also noted in head and neck tumor cell lines compared to cultured normal head and neck tissue cell lines. To assess the function of Smg-GDS expression in SCCHN, UM-SCC-1 cells were transfected with siRNA directed toward the 60.7 and 55.8 kD SmgGDS isoforms, with significant decreases in S-phase distribution for all treatments. Blocking both 60.7 and 55.8 kD SmgGDS isoforms with siRNA induced an 89% decrease in S-phase distribution as determined by Click-iT Edu cell cycle proliferation assay. These studies confirm an active role for SmgGDS protein function in the promotion of cancer cell proliferation in SCCHN, and provide the basis for further investigations into the role of small GTPases in head and neck neoplasia. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2143. doi:1538-7445.AM2012-2143
Visual Signaling in a High-Search Virtual World-based Assessment: A SAVE Science Design Study

Education policy in the United States centers K-12 assessment efforts primarily on standardized tests. However, such tests may not provide an accurate and reliable representation of what students understand about the complexity of science. Research indicates that students tend to pass science tests, even if they do not understand the concepts being assessed. On standardized tests, such concepts are typically assessed via multiple-choice questions, which may check student receptive understanding of science-related vocabulary terms rather than their ability to develop hypotheses and design experiments to test those hypotheses. In an attempt to address these assessment issues, our SAVE Science project has been exploring the use of immersive virtual environments as platforms for both learning and assessment. SAVE Science (Situated Assessment in Virtual Environments for Science Content and Inquiry) is an NSF-funded study exploring the use of virtual world-based tests to assess the science knowledge and skill of middle school students. The main goal of SAVE Science is to explore the value of virtual world-based assessments as supplements or alternatives to more traditional forms of assessment. In pursuit of that goal, we are examining design frameworks designed to help students manage the high cognitive load they may experience while completing the tests. In this paper, we present results from a study exploring the use of visual signaling techniques in virtual world-based assessments, with a particular focus on their use and impact in visually complex, high visual search environments. The study focused on the use of visual signaling to reduce perceived student cognitive load, while simultaneously increasing the number of interactions students perform with assessment-relevant objects in a virtual world (assessment efficiency).
Clinical assessment tools identify functional deficits in fragility fracture patients.

PURPOSE To identify inexpensive, noninvasive, portable, clinical assessment tools that can be used to assess functional performance measures that may put older patients at risk for falls such as balance, handgrip strength, and lumbopelvic control. PATIENTS AND METHODS Twenty fragility fracture patients and 21 healthy control subjects were evaluated using clinical assessment tools (Nintendo Wii Balance Board [WBB], a handheld dynamometer, and an application for the Apple iPod Touch, the Level Belt) that measure functional performance during activity of daily living tasks. The main outcome measurements were balance (WBB), handgrip strength (handheld dynamometer), and lumbopelvic control (iPod Touch Level Belt), which were compared between fragility fracture patients and healthy controls. RESULTS Fragility fracture patients had lower scores on the vertical component of the WBB Torso Twist task (P=0.042) and greater medial-lateral lumbopelvic sway during a 40 m walk (P=0.026) when compared to healthy controls. Unexpectedly, the fracture patients had significantly higher scores on the left leg (P=0.020) and total components (P=0.010) of the WBB Single Leg Stand task as well as less faults during the left Single Leg Stand task (P=0.003). CONCLUSION The clinical assessment tools utilized in this study are relatively inexpensive and portable tools of performance measures capable of detecting differences in postural sway between fragility fracture patients and controls.
Study on the intoxication matter in yellow rice wine and its controlling technology

In order to carry out the study on the high content of superior alcohol,and the study on its factors and controlling technology,the superior alcohol content of yellow rice wine is compared with that of other brewed wines.It proves that superior alcohol is both the matter of fragrance and flavor,and the matter of intoxication after drinking.The superior-alcohol-composition approaches in yellow rice wine include Pierre Lee the Greek system mechanism and special formation of amino acids.How to control the amount of superior alcohol in yellow rice wine production is introduced as well.
Hybrid array architectures for BMD radar systems

The proliferation of long range ballistic missiles has increased the need for radars capable of supporting early midcourse and ascent phase intercepts. In order to support these early midcourse and ascent phase intercepts, the ballistic missile defense (BMD) radar should be forward deployed. While a sea-based capability can be forward deployed, an easily transportable ground-based radar would be advantageous in certain scenarios. In this paper, we described a hybrid array antenna architecture that can provide target tracking performance similar to a conventional array design, but requires approximately 50 percent less prime power and cooling. In phased array antennas, the prime power and cooling requirements are dominated by the transmit portion of the antenna. Since the receive portion of the antenna requires only a small fraction of the total power, the prime power and cooling required can be reduced by approximately 50 percent by using a hybrid array architecture with only half the number (0.5N) of transmit/receive (T/R) modules as used in a conventional array. These T/R modules are located in the central core of the antenna and receive-only modules are added around the central core to compensate for the lost radar sensitivity. For this hybrid array to maintain the same power-aperture-gain (PAG) performance as the conventional array consisting of N T/R modules, approximately three and one half times as many (3.5N) receive-only modules will be required. Note that for tracking and discrimination, PAG is the appropriate measure for radar performance. The hybrid array architecture results in a large, but relatively lightweight, aperture. However, the antenna can be manufactured in a modular form, so that sections of the antenna can be shipped separately with final assembly being performed at the deployment site. Since receive-only modules have the potential to cost significantly less than T/R modules, the total antenna cost may still be lower than the conventional antenna with only T/R modules. Since the prime power, and therefore the DC power, required is reduced by 50 percent, the associated transmit portion of the antenna weight is reduced significantly. As a result, the total antenna weight of the hybrid array should still be less than the conventional antenna weight. Also, the rate of fuel consumption required to run the generators that power the array will also be reduced by approximately 50 percent, which eases the logistical burden of supplying fuel.
Flexible Hybrid Electronic Circuits and Systems

Printed organic electronics are being explored for a wide range of possible applications, with much of the current focus on smart labels, wearables, health monitoring, sensors and displays. These applications typically integrate various types of sensors and often include silicon integrated circuits (IC) for computation and wireless communications. Organic thin film transistors (TFT), particularly when printed, have performance and yield limitations that must be accommodated by the circuit design. The circuit design also needs to select sensor technology, ICs and other circuit elements to integrate with the TFTs and match the functional and performance requirements of the application. This paper describes organic TFT properties and strategies for circuit and sensor design, with examples from various sensor systems.
Fundamental and Clinical Considerations of the Muscles of the Hip

This chapter will provide an overview of the actions of hip muscles, with a focus on understanding a muscle’s action based on its line-of-force. Discussions will highlight on how the position of the hip at a given time affects the torque and ultimate action of certain hip muscles. Other mechanical aspects of hip muscle function will be discussed, such as how the forces generated by muscle contraction affect the stress on the hip and its periarticular tissues. This chapter should serve as a foundation for physicians and rehabilitation specialists who direct and provide care for patients following hip arthroscopic surgery.
The All or None Principle

(1923). The All or None Principle. American Physical Education Review: Vol. 28, No. 9, pp. 409-412.
Elastic constants of epitaxial cubic MoNx(001) layers

Abstract The N-to-Mo ratio x in epitaxial cubic molybdenum nitride γ -MoN x (001) layers was varied from x = 0.69–1.25 by adjusting the substrate temperature T s = 1000–600 °C during reactive magnetron sputter deposition. X-ray diffraction, reflection, and reciprocal space mapping measurements in combination with Rutherford backscattering spectroscopy indicate that the layers exhibit negligible strain and that increasing x = 0.69–1.25 leads to an increasing lattice constant a = 4.16–4.26 A and a decreasing density ρ = 8.7–6.8 g/cm 3 which is primarily attributed to a decrease in the cation site occupation from 0.89 to 0.70. Time resolved pump-probe reflectivity measurements of the sound velocity parallel to the [001] growth direction indicate that increasing the nitrogen concentration leads to a velocity reduction, corresponding to a decrease in C 11 from 502 ± 31 to 355 ± 30 GPa for x = 0.69–1.25. Similarly, the transverse surface acoustic wave velocity measured by surface Brillouin scattering spectroscopy decreases from 4.00–3.52 km/s, providing values for C 44 from 100 ± 7 to 73 ± 3 GPa. The softening with increasing N concentration is primarily attributed to the decreasing Mo site occupancy, which causes a reduction in the valence electron concentration leading to a weakening of N Mo bonds associated with hybridized N 2 p - Mo 4 d e g orbitals.
Global Association of Air Pollution and Cardiorespiratory Diseases: A Systematic Review, Meta-Analysis, and Investigation of Modifier Variables.

Background. Little is known about the health risks of air pollution and cardiorespiratory diseases, globally, across regions and populations, which may differ because of external factors.Objectives. We systematically reviewed the evidence on the association between air pollution and cardiorespiratory diseases (hospital admissions and mortality), including variability by energy, transportation, socioeconomic status, and air quality.Search Methods. We conducted a literature search (PubMed and Web of Science) for studies published between 2006 and May 11, 2016.Selection Criteria. We included studies if they met all of the following criteria: (1) considered at least 1 of these air pollutants: carbon monoxide, sulfur dioxide, nitrogen dioxide, ozone, or particulate matter (PM2.5 or PM10); (2) reported risk for hospital admissions, mortality, or both; (3) presented individual results for respiratory diseases, cardiovascular diseases, or both; (4) considered the age groups younger than 5 years, older than 65 yea...
Application of MOSCED To Predict Limiting Activity Coefficients, Hydration Free Energies, Henry’s Constants, Octanol/Water Partition Coefficients, and Isobaric Azeotropic Vapor–Liquid Equilibrium

Modified Separation of Cohesive Energy Density (MOSCED) is a solubility parameter-based method to predict limiting activity coefficients. In addition to making quantitative predictions, MOSCED may additionally be used to understand the underlying molecular-level driving forces for intuitive solvent selection and formulation. A major improvement of MOSCED over similar solubility parameter methods is that it splits the association term. We show by example how this change allows MOSCED to better model the molecular interactions of associating fluids. While parametrized to predict limiting activity coefficients, we demonstrate the ability to predict hydration-free energies, Henry’s constants in water, and octanol/water partition coefficients. We focus on water as MOSCED was previously found to perform substantially worse when water was the solvent. Comparison is made to molecular simulation and mod-UNIFAC, and we find for the studied reference set that predictions with MOSCED were in better agreement with exp...
A Multifrequency GPS Signal Strong Equatorial Ionospheric Scintillation Simulator: Algorithm, Performance, and Characterization

This paper presents a physics-based, data-consistent, multifrequency GPS scintillation signal simulator. The simulator is based on the two-component power-law phase screen derived from real GPS scintillation measurements. The real data used to initialize the simulator, simulator outputs, and receiver-processed results are compared to demonstrate the simulator accuracy and the receiver processing effects. This simulator will enable better characterization of ionospheric scintillation effects and development of robust receiver algorithms during strong equatorial scintillation.
An historical overview of the National Network of Libraries of Medicine, 1985–2015

The National Network of Libraries of Medicine (NNLM), established as the Regional Medical Library Program in 1965, has a rich and remarkable history. The network’s first twenty years were documented in a detailed 1987 history by Alison Bunting, AHIP, FMLA. This article traces the major trends in the network’s development since then: reconceiving the Regional Medical Library staff as a “field force” for developing, marketing, and distributing a growing number of National Library of Medicine (NLM) products and services; subsequent expansion of outreach to health professionals who are unaffiliated with academic medical centers, particularly those in public health; the advent of the Internet during the 1990s, which brought the migration of NLM and NNLM resources and services to the World Wide Web, and a mandate to encourage and facilitate Internet connectivity in the network; and the further expansion of the NLM and NNLM mission to include providing consumer health resources to satisfy growing public demand. The concluding section discusses the many challenges that NNLM staff faced as they transformed the network from a system that served mainly academic medical researchers to a larger, denser organization that offers health information resources to everyone. This article has been approved for the Medical Library Association’s Independent Reading Program .
Low-Magnitude Forces for Bone Modeling and Remodeling in Dentofacial Orthopedics

To examine the evidence in support of light continuous forces for enhancing bone adaptation (modeling and remodeling) in orthodontics and dentofacial orthopedics. Clinical evidence suggests that light continuous orthodontic force can achieve physiologic expansion of the maxillary arch, but the long-term stability and the biological effects of the procedure are unclear. Compared to conventional orthodontic appliances that deliver heavy interrupted forces for tooth movement, the application of low-magnitude forces in animal models leads to anabolic modeling and remodeling of the alveolar bone in the path of orthodontic tooth movement. This results in dental translation and expansion of the alveolar process. Light continuous forces are preferable to heavy forces for more physiologic dentofacial orthopedics. The interaction of low-magnitude loads with soft tissue posture achieves therapeutic adaptation of the craniofacial skeleton. The increasing emphasis on genomic medicine and personalized treatment planning should focus on low-magnitude loads in orthodontics and dentofacial orthopedics.
Enhancing performance of cooperating agents in real-time diagnostic systems

We present a data-driven protocol and a supporting architecture for communication among cooperating intelligent agents in real-time diagnostic systems. The system architecture and the exchange of information among agents are based on simplicity of agents, hierarchical organization of agents, and modular non-overlapping division of the problem domain. These features combine to enable efficient diagnosis of complex system failures in real-time environments with high data volumes and moderate failure rates. Preliminary results of the real-world application of this work to the monitoring and diagnosis of complex systems are discussed in the context of NASA's interplanetary mission operations.
Opioids: Pharmacokinetics and Pharmacodynamics

Opiates have been used for pain control for several thousands of years, dating back to the times of the ancient Sumerians. The Sumerians documented poppy in their pharmacopoeia and called it “HU GIL,” the plant of joy (Benedetti 1987). In the third century bc, Theophrastus has the first documented reference to poppy juice (Macht 1915). The word opium is derived from the Greek name for juice obtained from the poppy, Papaver, and the Latin name for sleep inducing, somniferum. Arab traders brought opium to the Orient, where it was used to treat the symptoms of dysentery. Opium contains approximately 20 distinct naturally occurring alkaloids, called opiates, such as morphine or codeine. In 1805, a German pharmacist Sertuner isolated a pure substance in opium and called it morphine. Morphine is named after Morpheus, the Greek god of dreams. After this initial discovery, many more opium alkaloids were discovered. Robiquet isolated codeine in 1832, and Merck isolated papaverine in 1848. In 1898, Bayer Pharmaceuticals launched an alternative to opium and morphine, diacetylmorphine or heroin, from the German word for hero. By the middle of the nineteenth century, pure opium alkaloids, rather than basic opium preparations, spread throughout the medical community. Until the early twentieth century, opioid abuse in the United States increased because of unrestricted availability of opium along with a massive influx of opium-smoking immigrants from the Orient. In fact, Thomas Jefferson grew opium poppies at Monticello. In 1942, the Opium Poppy Control Act banned opium production in the United States (Booth 1999). It is important to differentiate “opioids,” which are substances that act on the opiate receptor, and the term “narcotic,” which is a substance that produces narcosis and can be abused, such as cocaine, cannabis, and barbiturates (Reisine 1996). Narcotics are derived from the Greek word for stupor. Narcotics were initially used for sleeping aid medications rather than for opiates. Narcotic is now a legal term for drugs that are abused. In 2007, 93% of the opiates on the world market originated in Afghanistan (United Nations Office on Drugs and Crime 2007). This amounts to an annual export value of about $64 billion.
Reflection Profiling of the Continental Crust

The COCORP program is devoted to collecting, analyzing, and interpreting high resolution seismic profiles using techniques which have been highly successful for hydrocarbon exploration in sedimentary basins. In six years of operation with a single conventional crew, over 3000 Km of section have been produced in I2 study areas. These profiles have sufficient resolution to show geologically informative structure at all depths in the crust. The high initial cost of data collection is more than justified by the geological value of the results.
A Method for Forecasting Hailstone Size at the Earth's Surface

All upper-air soundings in the United States have been evaluated since January 1, 1950 and 274 selected as representative of air in which hailstones of known size formed. These soundings are summarized and several parameters which are or may be useful in forecasting are discussed. A graph is presented, which permits the translation of a forecast of air structure into one of hailstone size and two groups of forecasts are summarized to show the validity of this forecasting tool. The forecasts discussed were prepared in practical situations by meteorologists on regular forecasting duty and issued before the storms occurred. They therefore constitute a real test of the method under working conditions. Evidence is presented to show a very striking relation between the incidence of surface hail and the height of the wet bulb freezing level above the terrain. It was found that in 91.6% of the 274 representative soundings, the wet bulb freezing levels were between 5000 and 12,000 feet above the surface and the la...
Solidarity.com? Class and collective action

In detailing the evolution of the economic landscape from factory town to electronic vil-lage and in discussing how class and collective action may be analyzed in the context of the electronic village, my goal has been to provide a framework that researchers can use to develop meaningful studies of class and collective action in the electronic village.
A Compact Dual-Band Antenna Based on SIW Technology

In this paper., a compact dual-band antenna based on substrate-integrated waveguide (SIW) technology is proposed. The antenna is comprised by three layers. The top layer is a SIW cavity-backed slot antenna while the middle layer is a quarter-mode SIW (QMSIW) antenna. A microstrip feeding line is configured on the bottom layer connecting to a vertically-oriented probe penetrating through the three layers to feed the antenna. Full-wave simulations show that two operational bands with unidirectional radiation along broadside direction are successfully achieved at 2.6 and 5.9 GHz. The fractional bandwidths are equal to 1.54% and 2.71 %., respectively. The overall size of the antenna is 33mm×43mm×5. 23mm, which is extremely compact. Moreover., parametric studies revealed that the two bands can be tuned separately by adjusting the appropriate design parameters.
Management of Recurrent Peptic Ulcer Disease

The advent of proton pump inhibitors (PPIs) and histamine-2 (H2) blockers has led to a significant decrease in the number of patients who require surgical management of peptic ulcer disease. However, there is still a small subset of patients with pathologies that will lead to recurrent peptic ulcer disease. Understanding these pathologies is critical in allowing clinicians to correctly identify and treat them.
The Low Dropout Regulator [A Circuit for All Seasons]

The low-dropout (LDO) regulator is an essential power management circuit in today’s systems on chip (SOCs). Much to grammarians’ chagrin, the noun regulator has been dropped, and the circuit is simply called the LDO. The need for supply voltage regulation, of course, goes back many decades.
Development of a Culturally-Oriented Website Usability Evaluation

As the uni-cultural studies of website usability have matured, the paucity of cross-cultural studies of usability become increasingly apparent. Moving toward these cross-cultural studies will require the development of a new tool to assess website usability in the context of cultural dimensions. This paper introduces the preliminary results from the first phase of this project and then presents the proposed method for the research in progress that specifically is directed to the development and quantitative evaluation of a measurement scale of a culture sensitive measurement of website usability. The recognition of the need to develop this scale resulted from the identification of culture-related shortcomings of previous measurement tools that have been used widely within the Management of Information Systems (MIS) literature.
The Congruence Principle Applied: Rethinking Equal Protection Review of Federal Alienage Classifications after Adarand Constructors, Inc. v. Peña

This article suggests that the Supreme Court's 1995 decision in Adarand Constructors, Inc. v. Pena constitutes a starting point for a renewed dialogue on the intersection of race, noncitizens' rights, and immigration law.Part I of this Article examines the historical foundations of the plenary power doctrine up to the current dichotomy between judicial review of state and federal alienage classifications under equal protection. Part II reviews the Adarand decision, arguing that Justice O'Connor's congruence principle provides the bulwark for a revision of judicial review of federal legislation, especially in light of the historical and continuing perception of Asian- and Latino-Americans as noncitizens. The Article briefly concludes that underlying the proposed model is the well-established tenet that the equal protection guarantee stands as the vanguard of minority rights against systematic government discrimination.
Abstract 1808: The anti-estrogen endoxifen altered bone morphology and reduced muscle function in mice

Endoxifen, the predominant CYP2D6 metabolite of the selective estrogen receptor modulator (SERM) tamoxifen, is currently being developed as a novel anti-estrogen therapy for the treatment of estrogen receptor (ER)+ breast cancer. Genetic polymorphism of CYP2D6 is a predictor of response to tamoxifen in patients, implicating endoxifen as one of the most active and relevant tamoxifen metabolites. Breast cancer patients treated with adjuvant endocrine therapies including aromatase inhibitors (AIs) and SERMs often report unmanageable musculoskeletal toxicities that can result in treatment discontinuation. While ER binding affinity and anti-tumor effects have been established in preclinical models, the effects of endoxifen on the musculoskeletal system are not fully known. Twenty-week female C57BL/6 mice underwent sham surgery or ovariectomy (OVX) and were treated daily with vehicle, the AI letrozole, or the SERM endoxifen. Body composition was assessed prospectively by DXA. Bone indices and marrow adipose tissue volume were measured by μCT and muscle contractility of the extensor digitorum longus (EDL) was measured ex vivo. After eight weeks, trabecular bone volume fraction (BV/TV) decreased by 50% in OVX-vehicle and OVX-letrozole mice, whereas BV/TV increased threefold in endoxifen mice relative to sham-vehicle. Despite the presence of significantly more trabecular bone following endoxifen treatment, cortical bone analyses revealed impaired periosteal and endosteal expansion of bone, resulting in reduced polar moment of inertia, which is a measure of resistance to fracture. Uterine weight increased significantly in endoxifen-treated mice relative to all OVX groups, similar to what is observed with tamoxifen treatment. Peripheral body fat, bone marrow adipose tissue, and circulating leptin were reduced by endoxifen, suggesting that the drug may elicit positive systemic metabolic effects. At the termination of the study, muscle-specific force was reduced in OVX-endoxifen mice relative to sham-vehicle, OVX-vehicle, and OVX-AI mice, despite no change in muscle mass. While endoxifen shows promise as a potent anti-estrogen therapy for the treatment of ER+ breast cancer, it may be important to monitor patients for endometrial proliferation, morphological changes in bone that increase fracture risk, and for musculoskeletal side effects that could reduce drug compliance. Citation Format: Laura Wright, Khalid Mohammad, Theresa Guise. The anti-estrogen endoxifen altered bone morphology and reduced muscle function in mice [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1808.
Florida Crop/Pest Profile: Sugarcane

Sugarcane (Saccharum interspecific hybrids) is the main source of sugar in the world. It is grown in more than 90 countries in tropical and subtropical regions. Cultivation techniques and production challenges vary by location (Rott 2017; Rott 2018). This 19-page document discusses characteristics of the sugarcane crop and pests affecting its production in Florida, which is the largest producer of sugarcane in the United States. Written by P. Rott, D. C. Odero, J. M. Beuzelin, R. N. Raid, M. VanWeelden, S. Swanson, and M. Mossler, and published by the UF/IFAS Agronomy Department, revised May 2018. https://edis.ifas.ufl.edu/pi207
Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients.

Hyperpolarized helium 3 magnetic resonance imaging (3He MRI) is useful for investigating pulmonary physiology of pediatric asthma, but a detailed assessment of the safety profile of this agent has not been performed in children. To evaluate the safety of 3He MRI in children and adolescents with asthma. This was a retrospective observational study. 3He MRI was performed in 66 pediatric patients (mean age 12.9 years, range 8–18 years, 38 male, 28 female) between 2007 and 2017. Fifty-five patients received a single repeated examination and five received two repeated examinations. We assessed a total of 127 3He MRI exams. Heart rate, respiratory rate and pulse oximetry measured oxygen saturation (SpO2) were recorded before, during (2 min and 5 min after gas inhalation) and 1 h after MRI. Blood pressure was obtained before and after MRI. Any subjective symptoms were also noted. Changes in vital signs were tested for significance during the exam and divided into three subject age groups (8–12 years, 13–15 years, 16–18 years) using linear mixed-effects models. There were no serious adverse events, but three minor adverse events (2.3%; headache, dizziness and mild hypoxia) were reported. We found statistically significant increases in heart rate and SpO2 after 3He MRI. The youngest age group (8–12 years) had an increased heart rate and a decreased respiratory rate at 2 min and 5 min after 3H inhalation, and an increased SpO2 post MRI. The use of 3He MRI is safe in children and adolescents with asthma.
Clearing drug interferences in myeloma treatment using mass spectrometry.

Abstract Objective To explore the possibility of using a combination of a rapid MALDI-TOF-MS method (Mass-Fix) in conjunction with higher resolution LC-ESI-QTOF-MS (miRAMM) measurements to discriminate the IgG kappa M-protein from daratumumab , elotuzumab and isatuximab in myeloma patients. Design & Methods 86 patients with an IgG kappa M-protein were spiked with therapeutic levels of the drugs and examined by Mass-Fix and miRAMM to establish the percent of cases that could be resolved by each method. The method was then applied to 21 samples from patients receiving one of the drugs. Results Mass-Fix was capable of resolving the t-mAb from M-protein for 87 percent of the spiked samples. For the cases unresolved by Mass-Fix, miRAMM was capable of resolving the remaining drug interferences. The 21 IgG kappa myeloma patients that were receiving the drugs were all resolved by Mass-Fix. Conclusion This proposed algorithm allows use of a clinical available assay (Mass-Fix) while maximizing the number of cases that can accurately resolve the t-mAb from the M-protein.
Presacral epidermoid cyst in a pediatric patient

Abstract Epidermoid cysts are benign cysts of ectodermal origin that are most commonly found on the face, trunk, and neck but have been infrequently described in the presacral region. Presacral epidermoid cysts are most commonly seen in middle-aged women and to our knowledge, only two previous cases have been reported in the pediatric population. In this case report, we present the case of a pediatric patient who underwent a total mass excision with formal coccygectomy for a presacral epidermoid cyst. We describe the differential diagnosis for a presacral mass in a pediatric patient and the clinical, radiographic, and histologic work up involved in obtaining the correct diagnosis. Finally, we discuss the surgical treatment options to remove the mass and to decrease the risk of local recurrence, infection, and other serious complications.
Colorectal cancer with first known case of simultaneous bilateral tibial metastases.

The most common osseous metastatic regions for colorectal cancer are the lumbar and sacral vertebrae and the pelvis. There are few reported cases of isolated solitary tibial metastasis, and simulta...
Am I Next? The Spillover Effects of Mega-Threats on Identity Threat, Identity Labor, and Withdrawal

Mega-threats – negative, identity-relevant events that receive significant media attention – are frequent occurrences in society, yet the influence of these events on individuals at work remains un...
Oral ulcerations as a sign of Crohn's disease in a pediatric patient: a case report.

Crohn's disease is an inflammatory intestinal disease of unknown etiology. The disease primarily affects whites, with both sexes being affected equally. A genetic predisposition exists. Symptoms frequently present in the second to third decades of life, although they may present in the pediatric and/or geriatric populations. Oral lesions are significant as they are frequently reported to precede intestinal symptoms. Treatment of Crohn's dis- ease is palliative, with a focus on remission. Pediatric and general dentists play a critical role in the early diagnosis of Crohn's disease. Evaluation of a pediatric patient with com- plaints of oral ulcerations, as well as gastrointestinal symptoms, fatigue, and/or weight loss requires prompt referral to a gastroenterologist for further evaluation for Crohn's disease. (Pediatr Dent. 2004;26:355-358)
Regulation of epidermal growth factor receptor signal transduction. Role of gangliosides.

The addition of gangliosides to tissue culture cells causes a decrease in the tyrosine protein kinase activity of the epidermal growth factor (EGF) receptor and an inhibition of EGF-stimulated growth. Based on these data, the hypothesis that the EGF receptor is physiologically regulated by gangliosides has been proposed by E.G. Bremer, J. Schlessinger, and S. Hakomori (J. Biol. Chem. (1986) 261, 2434-2440). To test this hypothesis, a mutant Chinese hamster ovary cell line (clone Idl D) that has a reversible defect in the biosynthesis of gangliosides (Kingsley, D.M., Kozarsky, K. F., Hobbie, L., and Krieger, M. (1986) Cell 44, 749-759) was investigated. The human EGF receptor cDNA was expressed in the mutant cells, and the properties of the EGF receptor were examined using cells grown under permissive and nonpermissive conditions. Changes in ganglioside expression were not observed to cause any significant alterations in the affinity or number of EGF receptors detected at the cell surface. However, decreased levels of ganglioside expression were associated with 1) increased EGF receptor autophosphorylation on tyrosine residues, and 2) increased EGF-stimulated cellular proliferation. The inverse correlation observed between the level of ganglioside expression and signal transduction by the EGF receptor is consistent with the hypothesis that the function of the EGF receptor is physiologically regulated by gangliosides.
Integrating Probabilistic Reasoning into a Symbolic Diagrammatic Reasoner.

An important part of diagram understanding is the problem of glyph recognition. This problem is challenging because a glyph may be drawn in many different ways and with varying levels of precision. Diagrams in general are rarely perfect and often filled with poorly-drawn glyphs. In order to understand a wide range of diagrams, a diagrammatic reasoner should recognize glyphs that deviate from standard forms. This paper presents a new mechanism for glyph recognition which combines a probabilistic representation with an existing symbolic diagrammatic reasoner. This reasoner, GeoRep, recognizes diagram glyphs using a set of rules supported by a logic-based truth-maintenance system (LTMS). Here we extend GeoRep’s LTMS to include nodes that encapsulate Bayesian networks. The result is a reasoner that can leverage the benefits of symbolic truth maintenance as well as that of probabilistic networks.
Topology and Continuous Functions

The main goal of this text is to give a complete presentation of integration and differentiation. Plainly a detailed study of set-theoretic topology would be out of place here. Similarly, a detailed treatment of continuous functions is outside our purview. Nevertheless, topology and continuity can be ignored in no study of integration and differentiation having a serious claim to completeness.
Age‐related changes of hyoid bone position in healthy older adults with aspiration

Objectives/Hypothesis Aspiration, the passage of a bolus below the vocal folds, increases morbidity and mortality in the elderly by increasing the risk of aspiration pneumonia and other conditions. We hypothesized that altered position of the hyoid bone associated with aging may negatively affect airway protection during swallowing (i.e., aspiration) in older adults. Study Design Retrospective study. Methods We re-reviewed computed tomography (CT) scans of the head from 40 older adults (65–80 years old), comprised of 20 aspirators and 20 nonaspirators, obtained from a previous cohort study. In addition, CT scans of the head from 40 young adults (20–40 years old) were retrieved from a medical records database. Three-dimensional reconstruction and 2-dimensional sagittal views were used to measure the distance between the mandible and hyoid bone. Comparisons between age groups, genders, and aspiration status were made. Results Older adults had a larger distance between the hyoid and mandible in both latitude and longitudinal positions compared to the young adults. Among older males, there was evidence that the hyoid bone in the aspirators tended to be positioned more posterior compared to the nonaspirators. Conclusions The distance between the hyoid and mandible is increased with aging, and a more posterior position of the hyoid bone is correlated with aspiration in older males. These findings suggest that age-related changes in hyoid bone position may be a component of decreased swallowing safety and aspiration in older adults and warrant further investigation. Level of Evidence N/A. Laryngoscope, 124:E231–E236, 2014
Parametric Sensitivity Analysis of Fuel Cell Dynamic Response

The dynamic behavior of a fuel cell is integral to the overall stability and performance of the power system formed by the fuel supply, fuel cell stack, power conditioner and electrical load. But present-day fuel cells have transient (dynamic) responses that are much slower than the responses of the typical power conditioner and load. Therefore, there is significant motivation to identify which fuel cell parameters have greater impact on the cell's transient response so as to facilitate improved designs of such cells. This paper describes the results obtained from a sensitivity analysis performed on an input-output transfer function that is derived from a linear small-signal model of PEM fuel cell dynamics. These provide greater insight into the issue of which physical parameters have the greater impacts on fuel cell dynamic response.
Effect of estrogens on postpartum hypercoagulability and antithrombin III activity

Abstract Serial postpartum levels of antithrombin III activity, thrombin generation patterns, thrombelastograms, and fibrinogen were assessed in 10 women who were breast-feeding and 11 patients whose lactation was suppressed by stilbestrol. The markedly reduced antithrombin III activity demonstrated immediately following delivery had reverted to normal values one week post partum in the breast-feeding group, but its normalization was significantly delayed in the stilbestrol group (P