cssi/SciSciGPT-SciSciNet huggingface dataset:
Frequently used Active Learning Techniques and Their Impact: a Critical Review of Existing Journal Literature in the United States

This article examines the ‘lessons’ from the most recent Scholarship of Teaching and Learning research in political science that appears in three North American academic journals. The article focuses on the literature that examines the effectiveness of ‘active learning’ classroom techniques. Although the most commonly used technique to promote active learning is the in-class simulation, the evidence on the effectiveness of simulations is decidedly mixed. The article continues by exploring other available, but often ignored, active learning classroom techniques.
Task mapping on supercomputers with cellular networks

This thesis focuses on techniques of task mapping for solving problems on parallel computers with hundreds of thousands of processors on cellular networks. Task mapping is a serious intellectual challenge and a practical tool for unleashing the potential power of supercomputers. It is challenging because of both the astronomical searching space and the high dependence on the exact nature of the applications and the computers. In this thesis, we propose two general static mapping models to optimize the assignment of tasks on heterogeneous, distributed-memory, ultra-scalable computers. In our models, the underlying application problems can be appropriately decomposed to subtasks with known computational load and known inter-task communicational demands. We also know, or can conveniently measure, the computing systems' specifications such as individual processor speed and inter-processor communication cost. Our models abstract an application as a demand matrix and a parallel computer as a load matrix and a supply matrix with which we construct our models as minimizing the objective function value for completing the application on the given computer. We have tested several applications on Blue Gene/L supercomputer with 3D mesh and torus networks. For a 2D wave equation, the mappings generated by our models reduced communication by 51% for 3D-mesh and 31% for 3D-torus over the default MPI rank order mapping. For SMG2000 application, our mapping can reduce communication and total time by 16% and 5% over the default MPI rank order mapping, respectively. For NPB MG, we improve the communication time and benchmark result by 53% and 13%, respectively. For NPB CG, we improve the communication time and benchmark result by 43% and 22%, respectively. We believe that our models are useful for task assignment for broad applications on a family of supercomputers with cellular networks.
Affirmative Action for the Physically Disabled in Social Work Education

Abstract Physically disabled people belong to a distinctive minority group for whom affirmative action measures in social work education and employment are long overdue. That the disabled have been neglected is reflective of their circumstances generally and of the existence of other priorities for affirmative action in social work. The author discusses why affirmative action for the disabled is warranted, identifies issues and needs that must be considered in developing affirmative action programs, and suggests means for identifying and recruiting qualified disabled students.
Graduate Education in Instructional Systems: A Review of Selected Programs.

While demographic characteristics vary among programs, competencies and content emphasized in graduate study in instructional systems are common to a number of programs. For example, the master’s degree is intended to prepare students for employment as instructional developers in business and industry. There is a noticeable lack of emphasis on preparation for employment in public or private elementary or secondary school settings, which is uncharacteristic of the typical master’s degree program in education. Doctoral programs in instructional systems exhibit more variability in the areas of content, competencies, and the emphasis of competencies in an ideal program than do master’s degree programs. Each program, along with an individual emphasis in a particular component of instructional systems, stresses research methodology. Thus, the faculties within the various programs and their respective graduates can pursue knowledge in instructional systems on a range of concerns. The most significant characteristic of the instructional systems programs surveyed is the nature of the curriculum and course offerings. Instructional development courses overwhelmingly outnumber all other courses, with secondary areas of emphasis being instructional psychology, visual technology, management, and research. The emphasis placed on content and competencies other than media is an indication of the present direction of instructional systems. Although many of the programs evolved from an earlier audiovisual orientation, present programs now represent a concern with process rather than product and show a healthy diversity of content emphases within instructional systems.
Analysis of Lageos' altitude decrease

The paper treats the inverse problem of celestial mechanics which consists of determining the force field or potential from given or observed orbit(s). From the observational information, according to which Lageos loses approximately 1 mm altitude per day, a linear partial differential equation is formulated. The solution of this equation gives the field responsible for the above-mentioned, as yet unexplained, small but well established secular decrease in the semi-major axis. Note that the altitude-loss is not due to air-drag because of the very high altitude of this satellite.
Winning – Jack Welch

Book reviewed: Jack Welch (with Suzy Welch), Winning. New York, NY: Harper Business, 2005: Pages 372; Price US$27.95.
The Impact of Centers and Institutes on Faculty Life: Findings from a Study of Life Sciences Faculty at Research-Intensive Universities’ Medical Schools

This article reports on the impact of organized research centers on professional effort, productivity, and perceptions of work satisfaction for life sciences faculty members at research intensive universities’ medical schools in the U.S. Results indicate that senior center-affiliated faculty members taught less but worked more total hours than peers not affiliated with centers. Senior affiliated faculty members were more productive than their non-affiliated peers and were more likely to be principal investigators on externally funded grants. Center-affiliated faculty members were more likely to be dissatisfied with their mix of activities and workload but more likely to be satisfied with job security and autonomy. Implications beyond this context are suggested.
A methodology for chip-level electromigration risk assessment and product qualification

Even after the successful introduction of Cu-based metallization, the electromigration (EM) failure risk has remained one of the most important reliability concerns for most advanced process technologies. Ever increasing operating current densities and the introduction of low-k materials in the back-end process scheme are some of the issues that threaten reliable, long-term operation at elevated temperatures. The traditional method of verifying EM reliability only through current density limit checks is proving to be inadequate in general, or quite expensive at the best. A Statistical EM Budgeting (SEB) methodology has been proposed to assess more realistic chip-level EM reliability from the complex statistical distribution of currents in a chip. To be valuable, this approach requires accurate estimation of currents for all interconnect segments in a chip. However, no efficient technique to manage the complexity of such a task for very large chip designs is known. We present an efficient method to estimate currents exhaustively for all interconnects in a chip. The proposed method uses precharacterization of cells and macros, and steps to identify and filter out symmetrically bi-directional interconnects. We illustrate the strength of the proposed approach using a high-performance microprocessor design for embedded applications as a case study.
A field study of azimuthal seismic anisotropy in fractured carbonates at Canyon Lake, central Texas

Many important hydrocarbon fields worldwide produce from fractured carbonate reservoirs. For those fields, azimuthal seismic anisotropy potentially provides a means to map fracture orientation and distribution in the subsurface.
Trends in neurovascular complications of surgical management for carotid body and cervical paraganglionmas: A fifty-year experience with 153 tumors

Almost 75% of carotid body and cervical paragangliomas are adherent to or surround adjacent arteries and cranial nerves. Their resection can result in neurovascular injury, stroke, and excessive blood loss. To assess trends in neurovascular complications, we reviewed 153 carotid body and cervical paragangliomas that were surgically managed between 1935 and 1985. Results of the past 10 years were compared with two previous time periods: period I (1935 to 1965), when carotid artery reconstruction was uncommon at our institution, and period II (1966 to 1975), when methods of intraoperative electroencephalographic monitoring and carotid patch angioplasty were being developed. During the past 10 years (period III), surgical approach to these tumors has included intraoperative monitoring of cerebral blood flow, selective use of shunts, vein patch or graft reconstructions after extensive tumor resections, and mobilization of the parotid gland to facilitate adequate exposure of high tumors. Although tumor resection was attempted in 80% of patients in period I, surgical resection was complete in 98% during periods II and III. Three trends were observed: (1) The perioperative stroke rate has decreased dramatically from 23% in period I to 2.7% in period III (p = 0.007); (2) the perioperative mortality rate has been reduced from 6% in period I to no deaths in the past 10 years, but (3) the rate of postoperative cranial nerve dysfunction remains unchanged over 50 years (period I, 46%; period III, 40%). The median tumor size among patients with postoperative complications was significantly larger than those without complications (median size: 17 vs. 7 cm3, p = 0.004).(ABSTRACT TRUNCATED AT 250 WORDS)
Intelligence Vs. Wisdom: The Love of Money, Machiavellianism, and Unethical Behavior across College Major and Gender.

This research investigates the efficacy of business ethics intervention, tests a theoretical model that the love of money is directly or indirectly related to propensity to engage in unethical behavior (PUB), and treats college major (business vs. psychology) and gender (male vs. female) as moderators in multi-group analyses. Results suggested that business students who received business ethics intervention significantly changed their conceptions of unethical behavior and reduced their propensity to engage in theft; while psychology students without intervention had no such changes. Therefore, ethics training had some impacts on business students’ learning and education (intelligence). For our theoretical model, results of the whole sample (N = 298) revealed that Machiavellianism (measured at Time 1) was a mediator of the relationship between the love of money (measured at Time 1) and unethical behavior (measured at Time 2) (the Love of Money → Machiavellianism → Unethical Behavior). Further, this mediating effect existed for business students (n = 198) but not for psychology students (n = 100), for male students (n = 165) but not for female students (n = 133), and for male business students (n = 128) but not for female business students (n = 70). Moreover, when examined alone, the direct effect (the Love of Money → Unethical Behavior) existed for business students but not for psychology students. We concluded that a short business ethics intervention may have no impact on the issue of virtue (wisdom).
A Framework for Automatic Adaptation of Tunable Distributed Applications

Increased platform heterogeneity and varying resource availability in distributed systems motivate the design of i>resource-aware applications, which ensure a desired performance level by continuously adapting their behavior to changing resource characteristics. In this paper, we describe an application-independent adaptation framework that simplifies the design of resource-aware applications. This framework eliminates the need for adaptation decisions to be explicitly programmed into the application by relying on two novel components: (1) a i>tunability interface, which exposes adaptation choices in the form of alternate application configurations while encapsulating core application functionality; and (2) a i>virtual execution environment, which emulates application execution under diverse resource availability enabling off-line collection of information about resulting behavior. Together, these components permit automatic run-time decisions on i>when to adapt by continuously monitoring resource conditions and application progress, and i>how to adapt by dynamically choosing an application configuration most appropriate for the prescribed user preference. We evaluate the framework using an interactive distributed image visualization application and a parallel image processing application. The framework permits automatic adaptation to changes in execution environment characteristics such as available network bandwidth or data arrival pattern by choosing a different application configuration that satisfies user preferences of output quality and timeliness.
Propagation in shielded microslot on ferrite substrate

Using the method of moments, analysis is implemented for a completely shielded microslot on a ferrite substrate, i.e. a slotline with a parallel ground plane. Accuracy in the propagation constant as a function of slot line geometry, ferrite parameters and magnetising field of within 1% is obtained using matrices as small as five-by-five.
Optimal Estimation of Dynamically Consistent Kinematics and Kinetics for Forward Dynamic Simulation of Gait

Background Forward dynamic simulation provides a powerful framework for characterizing in vivo loads, and for predicting changes in movement due to injury, impairment or surgical intervention. However, the computational challenge of generating simulations has greatly limited the use and application of forward dynamic models for simulating human gait.
Prognostic scoring systems in patients with follicular thyroid cancer : a comparison of different staging systems in predicting the patient outcome

Background: The use of prognostic scoring systems is important for predicting the survival of individuals with thyroid carcinoma. Relatively few studies have addressed this issue for patients with follicular thyroid cancer. The goal of this retrospective study was to establish the best and most pertinent prognostic scoring system to predict survival in patients with follicular thyroid cancer. Methods: We selected 86 patients with follicular thyroid cancer treated at University of California, San Francisco (UCSF) hospitals from January 1954 to April 1998. The mean follow-up time was 11.5 years. There were 60 women (70%) and 26 men (30%), with a mean age if 48.6 years. Prognostic scoring systems included tumor, node, metastases (TNM), European Organization for Research and Treatment of Cancer (EORTC), Age, Grade, Extent, Size (AGES), Age, Metastases, Extent, Size (AMES), and the Metastases, Age, Completeness of resection, Invasion, Size (MACIS). Survival time was calculated using the Kaplan-Meier method. Us...
Towards Change Propagating Test Models in Autonomic and Adaptive Systems

Autonomic and adaptive computing systems can add, remove, and replace their own components in response to a changing environment. Self-adaptation facilitates the performance of automated maintenance and configuration tasks, but makes it possible for faults to be introduced into the software at runtime. To address this issue, researchers have developed approaches for integrating runtime testing into autonomic and adaptive software systems. An important aspect of runtime testing approaches for autonomic software is the provision of a framework for regression testing, which determines whether modifications have introduced faults into previously tested components. However, after adaptation occurs in autonomic software, a predefined test set may no longer be applicable due to changes in the program structure. Investigating techniques for dynamically updating regression tests after adaptation is therefore necessary to ensure such approaches can be applied in practice. In this paper we describe a model-driven approach that maps structural adaptations in autonomic software, to updates for its runtime test model. We provide a workflow and meta-model to support the approach, referred to as Test Information Propagation (TIP). To demonstrate TIP, we have developed a prototype that simulates a reductive change to an autonomic, service-oriented healthcare application. Conducting the simulation has provided us with much insight into this highly challenging research problem.
Low Calcium Intake Among African Americans: Effects on Bones and Body Weight

This review was performed to summarize and integrate the evidence relating calcium intake to health status in African Americans with special attention to bone and fat. Despite lower average calcium intakes, African Americans typically have skeletons more massive than those of whites. This is the result of a relative resistance of the bony resorptive apparatus to parathyroid hormone, which forces better urinary conservation of calcium and, at some life stages, more efficient intestinal calcium absorption as well. This adaptation, however, has other costs and appears to contribute to a greater risk in African Americans for several chronic diseases, including cardiovascular disease and stroke, obesity, and the insulin resistance syndrome. Higher calcium intakes not only support the skeleton in African Americans, just as they do in whites, but reduce the disease burden for other chronic diseases as well.
Reactivity of TpRu(L)(NCMe)R (L = CO, PMe3; R = Me, Ph) systems with isonitriles : Experimental and computational studies toward the intra-and intermolecular hydroarylation of isonitriles

Abstract The Ru(II) phenyl complex TpRu(PMe3)(NCMe)Ph {Tp = hydridotris(pyrazolyl)borate} reacts with isonitriles to form complexes of the type TpRu(PMe3)(C NR)Ph (R = tBu, CH2Ph, CH2CH2Ph). Neither thermal nor photolytic reactions of these systems with excess isonitrile and benzene resulted in the production of corresponding imines. DFT studies that probed the energetics of the desired catalytic transformations revealed that (Tab)Ru(PH3)(C NCH2CH2Ph)Ph {Tab = tris(azo)borate} is the most stable species in a proposed catalytic cycle. Exclusive of calculated transition states, the highest points on the calculated free energy surface are 34 kcal/mol, for (Tab)Ru(PH3)(o,η2-C,C-CNCH2CH2Ph)Ph {relative to the starting material (Tab)Ru(PH3)(C NCH2CH2Ph)Ph}, and 27 kcal/mol for the C–H activation product (Tab)Ru(PH3)(o-C6H4CH2CH2NC) and benzene. The substantial increases in free energy result primarily from the loss of the stable ruthenium–η1-isonitrile interaction.
Individual and Combined Roles of the Master Regulators AphA and LuxR in Control of the Vibrio harveyi Quorum-Sensing Regulon

Bacteria use a chemical communication process called quorum sensing to control transitions between individual and group behaviors. In the Vibrio harveyi quorum-sensing circuit, two master transcription factors, AphA and LuxR, coordinate the quorum-sensing response. Here we show that AphA regulates 167 genes, LuxR regulates 625 genes, and they coregulate 77 genes. LuxR strongly controls genes at both low cell density and high cell density, suggesting that it is the major quorum-sensing regulator. In contrast, AphA is absent at high cell density and acts to fine-tune quorum-sensing gene expression at low cell density. We examined two loci as case studies of coregulation by AphA and LuxR. First, AphA and LuxR directly regulate expression of the genes encoding the quorum-regulatory small RNAs Qrr2, Qrr3, and Qrr4, the consequence of which is a specifically timed transition between the individual and the group life-styles. Second, AphA and LuxR repress type III secretion system genes but at different times and to different extents. The consequence of this regulation is that type III secretion is restricted to a peak at mid-cell density. Thus, the asymmetric production of AphA and LuxR coupled with differences in their strengths and timing of target gene regulation generate a precise temporal pattern of gene expression.
Stress Distribution in Anisotropic Viscoelastic Hollow Sphere

The stress and deformation analysis of an anisotropic linear viscoelastic hollow sphere under a symmetrical loading on the boundaries is considered. In order to reduce some of the mathematical difficulties, assumptions of small strain with quasistatic stress-strain conditions are consistently made. The solution is found for a system of non-homogeneous anisotropic viscoelastic media, and subsequently reduced to that for a homogeneous medium. Numerical results for both short-time and long-time behavior are presented for a number of simple model media in the anisotropic viscoelastic case and compared with the result for the elastic or viscoelastic medium in the isotropic case.
Music Instruction and its Diverse Extra-Musical Benefits

this article provides an overview of our research , including studies yet unpublished, on the effects of music on cognition. Music instruction can enhance children9s spatial-temporal reasoning, numerical reasoning, and phonemic awareness. Longitudinal studies of middle-income and economically disadvantaged preschoolers reveal that children who receive music instruction prior to age 7 show improved performance on spatial-temporal and numerical reasoning tasks compared to children in control groups—effects that persist for two years after the intervention ends. Three additional studies suggest that teacher gender may influence these transfer effects in children. Our studies also show improved perceptual discrimination as a function of music training: adult string players have lower than average pitch discrimination thresholds, whereas adult percussionists have lower than average temporal discrimination thresholds. These effects are strongest for musicians who begin their training before age 7. Related to these improvements in perceptual discrimination, children provided with violin instruction perform better than controls on tasks measuring phonemic awareness, a skill that correlates strongly with pitch discrimination and is related to reading acquisition.
On the design of broad-band loaded wire antennas using the simplified real frequency technique and a genetic algorithm

A novel design methodology for broad-band loaded wire antennas is presented that combines the genetic algorithm and the simplified real frequency technique (SRFT) to remove the requirement of choosing the types of load circuits and matching networks a priori. Analytical expressions for the impedance functions of load circuits and matching networks are obtained in the form of rational polynomials via the SRFT. The location of loads on the antenna and the resistance functions of the load circuits and matching networks are optimized using a genetic algorithm. Maximization of system gain in the azimuth and minimization of voltage standing wave ratio are sought as design objectives. The circuit topologies and the component values are automatically arrived at using Darlington synthesis after the optimization process is complete. Also demonstrated, is the use of this procedure to achieve broad-band operation in the HF band for the unloaded and loaded monopoles assuming electronically switched matching networks.
Molecular Interactions and Cellular Itinerary of the Yeast RAVE (Regulator of the H+-ATPase of Vacuolar and Endosomal Membranes) Complex

The RAVE complex (regulator of the H+-ATPase of vacuolar and endosomal membranes) is required for biosynthetic assembly and glucose-stimulated reassembly of the yeast vacuolar H+-ATPase (V-ATPase). Yeast RAVE contains three subunits: Rav1, Rav2, and Skp1. Rav1 is the largest subunit, and it binds Rav2 and Skp1 of RAVE; the E, G, and C subunits of the V-ATPase peripheral V1 sector; and Vph1 of the membrane Vo sector. We identified Rav1 regions required for interaction with its binding partners through deletion analysis, co-immunoprecipitation, two-hybrid assay, and pulldown assays with expressed proteins. We find that Skp1 binding requires sequences near the C terminus of Rav1, V1 subunits E and C bind to a conserved region in the C-terminal half of Rav1, and the cytosolic domain of Vph1 binds near the junction of the Rav1 N- and C-terminal halves. In contrast, Rav2 binds to the N-terminal domain of Rav1, which can be modeled as a double β-propeller. Only the V1 C subunit binds to both Rav1 and Rav2. Using GFP-tagged RAVE subunits in vivo, we demonstrate glucose-dependent association of RAVE with the vacuolar membrane, consistent with its role in glucose-dependent V-ATPase assembly. It is known that V1 subunit C localizes to the V1-Vo interface in assembled V-ATPase complexes and is important in regulated disassembly of V-ATPases. We propose that RAVE cycles between cytosol and vacuolar membrane in a glucose-dependent manner, positioning V1 and V0 subcomplexes and orienting the V1 C subunit to promote assembly.
Building on the intrinsic resiliency of children/youth impacted by HIV/AIDS: a participatory study in India.

During August-September 2013 this research was conducted in two sites of World Vision India’s GRACE Project that specialize in providing care and support to children/adolescents (ages 11-19) impacted by HIV/AIDS in Chennai.1 This qualitative report presents the findings alongside a literature review that focuses on building resiliency upon the “innate capacities” of children/adolescents impacted by HIV/AIDS towards psychosocial vocational and spiritual flourishing. In order to better understand the ways in which programs can respond to the true needs of this demographic the interviews and focus groups were framed with a participatory grassroots approach to discover unique challenges future dreams and existing capabilities.2 This study addresses the nature of resiliency in transformational development by exploring its engagement with the interlocking dimensions of well-being in four sections: 1) framing immediate needs and integrated programming 2) social support and the role of kinship in transformational development 3) enhancing vocational resiliency through participatory development and 4) identity reformation and redeemed relationships within the Kingdom of God.
Evaluating Subsampling Methods for Estimating Numbers of Varroa jacobsoni Mites (Acari: Varroidae) Collected on Sticky-Boards

Six subsampling methods for estimating the number of Varroa jacobsoni (Oudemans) mites on sticky-boards were evaluated. Each method was based on stratified random sampling and was evaluated on 3 groups of boards: those with an undetermined number of mites, those with >500 mites, and those with >1,000 mites. A working compromise between efficiency and precision was obtained by randomly sampling half of the cells in each of 96 two-cell strata. For this method and these 3 groups of boards, estimates of the number of mites on individual boards were within 38.46, 5.93, and 5.03%, respectively, of the true value 95% of the time. Evaluation of this method on a different set of 120 boards gave similar results. Using the same method, estimates of the total number of mites on 3 boards from the same colony were within 3.33% of the true value 95% of the time. These results demonstrate that subsampling can reduce the amount of time required to determine the number of mites on a sticky-board by approximately one half.
Use of Supersonic Microjets for Active Separation Control in Diffusers

Inlets to aircraft propulsion systems must supply flow to the compressor with minimal pressure loss, distortion or unsteadiness. Flow separation in inlets and ducts can reduce the overall system performance. The present paper describes an experimental investigation carried out to study the feasibility of using supersonic microjets to control boundary layer separation in an adverse pressure gradient. The geometry used for this study is a simple diverging “Stratford ramp” equipped with arrays of 400!m supersonic microjets. Measurements include detailed surface flow visualizations, surface pressure distributions, flow visualizations and velocity field measurements using Particle Image Velocimetry. The results clearly indicate that by activating these microjets, the separated flow was eliminated. This was achieved with minimal mass flux, lower than 1.5 % of the primary flow. The activation of microjets and the resulting elimination of separated flow led to a significant increase in the momentum of the flow near the surface. The increase in momentum was at least an order of magnitude higher than the momentum injected by the microjets. As such, supersonic microjets appear to be very effective actuators for separation control.
A further study of amino acid analysis and conditioning of planarians

Two groups of planaria regenerated from heads or tails were subdivided into groups in which CS and UCS were either paired or non-paired. After 120 presentations of CS and UCS the animals were subjected to amino acid analysis. Significant behavioral differences were found, but biochemical-behavioral correlations were not significant.
Effects of membrane peroxidation on [3H]acetylcholine release in rat cerebral cortical synaptosomes.

[3H]Acetylcholine (ACh) release, malonaldehyde formation and45calcium-uptake were measured in rat cerebral cortical nerve terminal that were exposed to various concentrations of ferrous and ascorbate ions. At a constant molar ratio of 25:1, ferrous:ascorbate, these ions increased malonaldehyde (MA) synthesis in a concentration-dependent manner. Treatment with these ions in the same ratio also induced a dose-related inhibition of the K+-depolarization-induced release of newly synthesized [3H]ACh. Combined exposure to Fe2+/ascorbate also reduced calcium ionophore A23187-induced [3H]ACh release. Neither ferrous nor ascorbate ions alone altered depolarization-or ionophore-induced [3H]ACh release over this concentration range. Depolarization- and A23187-induced45calcium uptake were not affected by peroxidation, suggesting that membrane peroxidation influenced some process in the release-process subsequent to calcium influx in a manner similar to what is observed during aging.
Abstract 4429: EGR1-MIR152pathway overcomes acquired cisplatin resistance in ovarian cancer cells by inhibiting cyto-protective autophagy via ATG14

The cytotoxic-based platinum compound cisplatin has been commonly used in ovarian cancer treatment for almost three decades. However, the intrinsic and acquired resistance to cisplatin in cancer cells remains a big challenge for overall survival. A growing body of evidence indicates a role of autophagy as a prosurvival and resistance mechanism against chemotherapy. Here, we reported MIR152 as a new autophagy-regulating miRNA that plays a role in cisplatin resistance. We showed that MIR152 expression was dramatically downregulated in the cisplatin-resistant cell lines A2780/CP70, SKOV3/DDP compared with their respective parental cells, and in ovarian cancer tissues associated with cisplatin resistance. Overexpression of MIR152 sensitized cisplatin-resistant ovarian cancer cells by reducing cisplatin-induced autophagy, enhancing cisplatin-induced apoptosis and inhibition of cell proliferation. A mouse subcutaneous xenograft tumor model using A2780/CP70 cells with overexpressing MIR152 was established and displayed decreased tumor growth in response to cisplatin. We also identified that ATG14 is a functional target of MIR152 in regulating autophagy inhibition. Furthermore, we found that EGR1 (early growth response 1) regulated the MIR152 gene at the transcriptional level. Ectopic expression of EGR1 enhanced efficacy of chemotherapy in A2780/CP70 cells. More importantly, these findings were relevant to clinical cases. Both EGR1 and MIR152 expression levels were significantly lower in human ovarian cancer tissues with high levels of ERCC1 (excision repair cross-complementation group 1), a marker for cisplatin resistance. Collectively, these data provide insights into novel mechanisms for acquired cisplatin resistance. Activation of EGR1 and MIR152 may be a useful therapeutic strategy to overcome cisplatin resistance by preventing cyto-protective autophagy in ovarian cancer. Note: This abstract was not presented at the meeting. Citation Format: Jun He, Jing-Jie Yu, Bing-Hua Jiang. EGR1- MIR152 pathway overcomes acquired cisplatin resistance in ovarian cancer cells by inhibiting cyto-protective autophagy via ATG14. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4429. doi:10.1158/1538-7445.AM2015-4429
Oil Migration Transporting Pathways in Nose Structure Region outside Oil Source Area and Their Controlling on Oil Accumulation——Example of Shangjia region in the Songliao basin

The Shangjia region is a nose structure.It is located outside the oil area of K_1qn~1 (lst Member,Qingshankou Formation,Lower Cretaceous) in the Sanzhao depression,Songliao Basin.In this region oil accumulation and distribution are controlled by transporting pathways. It is of important significances for orienting oil exploration and enriching oil--gas accumulation theory that transporting pathways of oil and their controlling on oil accumulation and distribution are recognized in a region.Using the method of oil source correlation,typical oil reservoirs anatomy and oil accumulation models,oil transporting process in the Shangjia region,Songliao basin,was studied.It is classified into 3 parts:(1) T2 faults connecting source--rock were transporting pathways for migration downward of oil from K_1qn~1 source rocks into Fuyu oil layer,Yangdachengzi oil layer,the 4th and the 3rd Member of the Lower Cretaceous Quantou Fm.,respectively,in the Sanzhao depression.(2) Sand bodies connecting by T_2-- T_(2-2) faults were transporting pathways for oil in Fuyu,Yangdachengzi oil layers migrating laterally from the Sanzhao depression to the Shangjia region.(3) T_2--T_(1-1) faults were transporting pathways for oil in Fuyu,Yangdachengzi oil layer migrating to Putaohua oil layer,the Lower Cretaceous Yaojia Fro.,in the Shangjia region.Using the method studying the relation between oil transporting pathways and oil distribution,controlling of transporting pathways on oil accumulation and distribution was studied.It was concluded that the more developed the faults were,the more sufficient the oil source for lateral migration from the Sanzhao depression to the Shangjia region was.The position and ability of transporting pathways which were sand bodies connected by T_2--T_(1-1) faults controlled the distribution and abundant degree of oil in Fuyu,Yangdachengzi oil layers and K_1q~2.The distribution of T_2--T_(1-1) faults transporting pathways controlled the abundant area of Putaohua oil layer in the Shangjia area.
Current situation and development of the quality standard research of traditional Chinese medicine

Here,we introduced the research and development directions of the quality standard of traditional Chinese medicine(TCM),expounded the development situation of TCM quality standards,and analyzed current problems and the reasons in TCM quality standards.In conclusion,the research of TCM quality standards must adhere to science studies,overall consideration and continuous improvement.Besides,the quality standard is only one of important measures to ensure the quality of TCM.Only enhanced the whole course quality control,the quality of TCM can be ensured to be uniform,stable and controllable.
Research progress of reasonable feeding and nursing in very low birth weight infant

With the constantly development of emergency treatments and nursing standard in China,the livability rate of very low birth weight infant(VLBWI) has increasing obviously.VLBWI refers to those infants whose birth weight is below 1500 g and each organ does not develop well especially the function of stomach.Nutrition support is the key link of improving the livability rate which not only influence infant′s weight increase and prognosis of disease,but also relate to the prognosis forward.Stress conditions of VLBWI are kind of a lot,which make the infants cannot be fed direct-ly or the feeding intolerance will appear.And the infants need parenteral nutrition to get enough power at this time.Im-proper feeding method will directly influence the infant′s nervous system development and totally support by parenteral nutrition will lead to liver fat changes,cholestasis,transaminase increase etc.Such liver injury could lead to hepatic fail-ure,so the reasonable feeding strategies are needed.The present thesis has made a review of nutrition metabolism and minimal feeding,intermittent feeding and continuous feeding in early stage,and caring strategies including proper feed-ing position,non-nutritive sucking,human milk fortifier,touching and the like,which aims to make reasonable feeding for the VLBWI.
Effect of Propranolol Therapy on Aldosterone Responses to Angiotensin II and Adrenocorticotropic Hormone in Essential Hypertension

1. The plasma aldosterone responses to exogenous angiotensin II and adrenocorticotropic hormone (ACTH) were studied before and after 1 month of propranolol therapy (120-240 mg/day) in eight patients with essential hypertension. 2. Basal supine plasma renin activity was decreased (P less than 0.001) after propranolol, whereas plasma aldosterone was unchanged. After 3 h of upright posture the increases in both plasma renin activity and aldosterone were decreased (P less than 0.05) after propranolol. 3. Plasma aldosterone responses to exogenous angiotensin II and ACTH were not significantly different after propranolol. Serum and urinary electrolytes and plasma cortisol were also unaffected by propranolol therapy. 4. It is concluded that changes in adrenal sensitivity are not responsible for maintaining unchanged supine plasma aldosterone concentrations after beta-adrenoceptor antagonism in essential hypertension.
Discovering better AAAI keywords via clustering with community-sourced constraints

Selecting good conference keywords is important because they often determine the composition of review committees and hence which papers are reviewed by whom. But presently conference keywords are generated in an ad-hoc manner by a small set of conference organizers. This approach is plainly not ideal. There is no guarantee, for example, that the generated keyword set aligns with what the community is actually working on and submitting to the conference in a given year. This is especially true in fast moving fields such as AI. The problem is exacerbated by the tendency of organizers to draw heavily on preceding years' keyword lists when generating a new set. Rather than a select few ordaining a keyword set that that represents AI at large, it would be preferable to generate these keywords more directly from the data, with input from research community members. To this end, we solicited feedback from seven AAAI PC members regarding a previously existing keyword set and used these 'community-sourced constraints' to inform a clustering over the abstracts of all submissions to AAAI 2013. We show that the keywords discovered via this data-driven, human-in-the-loop method are at least as preferred (by AAAI PC members) as 2013's manually generated set, and that they include categories previously overlooked by organizers. Many of the discovered terms were used for this year's conference.
Head Loss Characteristics of a Fibrous Bed in a PWR Chemical Environment

This paper examines the generation and effect of secondary materials created by chemical reactions between dislodged fiberglass insulation debris and simulated cooling system water that would be present within the containment of a pressurized water reactor following a loss-of-coolant accident (LOCA). Corrosion and subsequent precipitation of metals (aluminum, iron, zinc, and calcium) pose an important safety concern because the surface area of exposed metal inside containment represents a large potential source term of chemical debris products that may be capable of blocking the recirculation sump. The Advisory Committee on Reactor Safeguards (ACRS) cited the presence of gelatinous material recovered from the Three Mile Island containment pool after its 1979 accident and noted that the formation of adverse chemical products had not been previously examined under Generic Safety Issue 191 (GSI-191) research program. Based on small-scale tests, the following key issues related to corrosion and precipitation were investigated: 1. Do credible corrosion mechanisms exist for leaching metal ions from bulk solid surfaces, and if so, what are the typical reaction rate constants? 2. Can corrosion products accumulate in the containment pool water to the extent that they might precipitate as new chemical species at pH and temperature levels that are relevant to the LOCA accident sequence? 3. How do chemical precipitants affect the head loss across an existing fibrous debris bed? Findings from these tests confirmed that corrosion of metal can occur and that artificially induced metallic precipitants can cause substantial additional head loss.
Build an Instinct for Feelings

NURSING STANDARD Nurse directors A conference for existing and aspiring nurse directors in primary and secondary care will be held on May 21 in London. Some of the topics covered are preparing and applying for a nurse director position, support and resources for nurse directors, developing management and leadership skills, contributing in the boardroom, supporting the nurse workforce, leadership in difficult times, commissioning and making the transition from nurse director to chief executive. http://tinyurl.com/6vxh5up
A comparison of point defects in Cd1−xZnxTe1−ySey crystals grown by Bridgman and traveling heater methods

In this paper, the properties of point defects in Cd1−xZnxTe1−ySey (CZTS) radiation detectors are characterized using deep-level transient spectroscopy and compared between materials grown using two different methods, the Bridgman method and the traveling heater method. The nature of the traps was analyzed in terms of their capture cross-sections and trap concentrations, as well as their effects on the measured charge-carrier trapping and de-trapping times, and then compared for the two growth techniques. The results revealed that Se addition to CdZnTe can reduce the VCd− concentration. In Travelling Heater Method (THM) and Bridgman Method (BM) grown CZTS detectors, besides a few similarities in the shallow and medium energy traps, there were major differences in the deep traps. It was observed that the excess-Te and lower growth-temperature conditions in THM-grown CZTS led to a complete compensation of VCd− and two additional traps (attributed to Tei− and TeCd++ appearing at around Ev + 0.26 eV and Ec − ...
Sales Team Resources for Market-Driven Behaviors, Norms, and Performance: An Extended Abstract

A recent survey of 1200 sales executives indicated that in order to improve sales performance, leaders must champion salesperson activities that (1) improve customer experiences and (2) support continuous improvement (Accenture CSO Insights 2013). This contemporary focus represents a shift away from a formal mapping of sales approaches and toward an emphasis on sales teams which promote a learning- and customer-centric environment (Bell and Kozlowski 2002) to attune themselves with the market. In line with this, research has shown that learning effort (Sujan et al. 1994) and commitment to customer service quality (Peccei and Rosenthal 1997) are key to developing this more market-driven capability for salesperson performance.
Compression and recovery of carbon nanotube forests described as a phase transition

Abstract In this paper we describe experiments and a continuum phase transition model for the compression of carbon nanotube (CNT) forests. Our model is inspired by the observation of one or more moving interfaces across which densified and rarefied phases of the CNT forests co-exist. We use a quasi-static version of the Abeyaratne-Knowles theory of phase transitions for continua with a stick-slip type kinetic law and a nucleation criterion based on the critical stress for buckling of CNT forests to describe the formation and motion of these interfaces in uniaxial compression experiments. We investigate micropillars made from bare CNTs, as well as those coated with different thicknesses of alumina using atomic layer deposition (ALD). The coating thickness affects the moduli of individual CNTs as well as the adhesion energy per contact between CNTs. In order to test the applicability of our model to more complex stress states, we carry out nanoindentation experiments on the CNT pillars and interpret the load-indentation data by incorporating a constitutive law allowing for phase transitions into solutions for the indentation of a linearly elastic half-space. Even though the state of stress in a nanoindentation experiment is more complex than that in a uniaxial compression test, we find that the parameters extracted from the nanoindentation experiments are close to those from uniaxial compression. Our models could therefore aid the design of CNT forests to have engineered mechanical properties, and guide further understanding of their behavior under large deformations.
Analysis and compensation of asynchronous stock time series

The accurate computation of statistical quantities from sampled data is of paramount importance in the analysis of economic and financial time series. The Epps effect is an empirically observed phenomenon where the sample correlation between the logarithmic returns of two stock prices decreases as the sampling frequency of data increases. The full explanation of this phenomenon is currently an open problem and several potential contributing factors are reported in the scientific literature. However, asynchronous sampling times in the stock prices is one of the key components originating the Epps effect. This article investigates in a quantitative way how asynchronous price data contribute to the Epps effect by modeling stock prices as correlated geometric Brownian motions and considering trading times as Poisson point processes. Under these assumptions we show that the Epps effect can be considered as a statistical artifact producing a bias on the sample correlation of the logarithmic returns. We also provide an analytic expression describing this bias. This expression can be used to compensate the bias on the sample correlation in order to obtain an unbiased estimate.