cssi/SciSciGPT-SciSciNet huggingface dataset:
Immunoglobulins in nasal secretions and nasal mucosa in perennial rhinitis.

Quantitative identification of albumin, and immunoglobulin G, A, M and E in the nasal secretion and serum was done in 25 patients with perennial rhinitis and in 15 normal subjects. By immunofluorescent microscopy of biopsies from the inferior turbinate immunoglobulin-producing plasma cells were identified by using FITC-marked antiglobulin against IgG, IgA, IgM and IgE. The presence of IgG and IgA in the nasal secretion and serum was not significant, and there was no difference between normal and patient groups. IgM was detected in nasal secretion in the patient group, probably due to increased permeability of the mucosa. This explanation is supported by the fact that albumen was also found in a rather high concentration in the patient material. The presence of IgM-producing plasma cells was more frequently found in the patient group than in the control subjects and in those patients where presence of these cells was proved, a higher concentration of IgM in serum was shown, possibly indicating a generally ...
Portable, Chronic Neural Interface System Design for Sensory Augmentation

While existing work in neural interfaces is largely geared toward the restoration of lost function in amputees or victims of neurological injuries, similar technology may also facilitate augmentation of healthy subjects. One example is the potential to learn a new, unnatural sense through a neural interface. The use of neural interfaces in healthy subjects would require an even greater level of safety and convenience than in disabled subjects, including reliable, robust bidirectional implants with highly-portable components outside the skin. We present our progress to date in the development of a bidirectional neural interface system intended for completely untethered use. The system consists of a wireless stimulating and recording peripheral nerve implant powered by a rechargeable battery, and a wearable package that communicates wirelessly both with the implant and with a computer or a network of independent sensor nodes. Once validated, such a system could permit the exploration of increasingly realistic use of neural interfaces both for restoration and for augmentation.
Iso-Energy-Efficiency: An Approach to Power-Constrained Parallel Computation

Future large scale high performance supercomputer systems require high energy efficiency to achieve exaflops computational power and beyond. Despite the need to understand energy efficiency in high-performance systems, there are few techniques to evaluate energy efficiency at scale. In this paper, we propose a system-level iso-energy-efficiency model to analyze, evaluate and predict energy-performance of data intensive parallel applications with various execution patterns running on large scale power-aware clusters. Our analytical model can help users explore the effects of machine and application dependent characteristics on system energy efficiency and isolate efficient ways to scale system parameters (e.g. processor count, CPU power/frequency, workload size and network bandwidth) to balance energy use and performance. We derive our iso-energy-efficiency model and apply it to the NAS Parallel Benchmarks on two power-aware clusters. Our results indicate that the model accurately predicts total system energy consumption within 5\% error on average for parallel applications with various execution and communication patterns. We demonstrate effective use of the model for various application contexts and in scalability decision-making.
Wave Cycle Design for NOx-Limited Wave Rotor Core Engines for High Speed Propulsion

Direct work and pressure exchange between gases can be accomplished by cyclic wave processes in the channels of a wave-rotor, circumventing the limitations of turbo-compressors. A wave-rotor cycle is presented for use as the high-pressure core in a high speed aircraft engine with turbine bypass. The products of a “low-NOx” combustor undergo a large immediate wave-expansion to reach a permissible turbine blade temperature. The wave rotor provides a substantial increase in pressure ratio and peak cycle temperature resulting in high specific power and efficiency.Approximate analytical methods are employed for initial design and optimization of the cycle. The method of characteristics is then used to compute the detailed time evolution of the flow-field in a wave channel.Copyright © 1993 by ASME
A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis

Motivation: A major focus of current sequencing studies for human genetics is to identify rare variants associated with complex diseases. Aside from reduced power of detecting associated rare variants, controlling for population stratification is particularly challenging for rare variants. Transmission/disequilibrium tests (TDT) based on family designs are robust to population stratification and admixture, and therefore provide an effective approach to rare variant association studies to eliminate spurious associations. To increase power of rare variant association analysis, gene-based collapsing methods become standard approaches for analyzing rare variants. Existing methods that extend this strategy to rare variants in families usually combine TDT statistics at individual variants and therefore lack the flexibility of incorporating other genetic models. Results: In this study, we describe a haplotype-based framework for group-wise TDT (gTDT) that is flexible to encompass a variety of genetic models such as additive, dominant and compound heterozygous (CH) (i.e. recessive) models as well as other complex interactions. Unlike existing methods, gTDT constructs haplotypes by transmission when possible and inherently takes into account the linkage disequilibrium among variants. Through extensive simulations we showed that type I error was correctly controlled for rare variants under all models investigated, and this remained true in the presence of population stratification. Under a variety of genetic models, gTDT showed increased power compared with the single marker TDT. Application of gTDT to an autism exome sequencing data of 118 trios identified potentially interesting candidate genes with CH rare variants. Availability and implementation: We implemented gTDT in C++ and the source code and the detailed usage are available on the authors’ website (https://medschool.vanderbilt.edu/cgg). Contact: ude.tlibrednav@il.nahsgnib or ude.phc@nehc.iew Supplementary information: Supplementary data are available at Bioinformatics online.
Oral valganciclovir versus ganciclovir as delayed pre-emptive therapy for patients after allogeneic hematopoietic stem cell transplant: a pilot trial (04-0274) and review of the literature.

: Background Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). This pilot prospective randomized clinical trial compares valganciclovir (VGV) to ganciclovir (GCV) as pre-emptive therapy for CMV viremia in the post-allogeneic HSCT population. Methods Patients undergoing allogeneic HSCT who were at risk for CMV viremia were monitored post HSCT by weekly quantitative whole blood polymerase chain reaction. Pre-emptive therapy was delayed until the viral load (VL) was >10,000 copies/mL once, or >5000 copies/mL twice. Patients were randomized to either GCV 5 mg/kg twice a day (b.i.d.) for 7 days followed by daily GCV 5 mg/kg for up to 21 days, or VGV 900 mg b.i.d. for 7 days followed by 900 mg daily for up to 21 days. The primary endpoint was clearance of viremia (VL <5000 copies/mL) within 28 days of initiation of therapy. Result In total, 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease. Conclusions In this trial, the rates of clearance of viremia appear to be similar with VGV and GCV.
Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma.

Background Little is known about the molecular signature of the rare tumor sinonasal squamous cell carcinoma (SNSCC). The purpose of this study was to comprehensively assess various molecular biomarkers in SNSCC. Methods We chose 13 markers for this study, which have been known as prognostic markers in head and neck squamous cell carcinoma. Expression of these markers was examined by either in situ hybridization or immunohistochemical methods on tissue microarrays made from 70 SNSCC specimens and 28 matched-pair normal tissues from patients who underwent surgical resection at our institution. Expression data were correlated with patient clinicopathologic parameters and survival. Results Of the 13 markers, only epidermal growth factor receptor (EGFR) protein expression was associated with significantly shorter disease-free survival (DFS; p = .01307). EGFR expression was also associated with shorter overall survival (OS), but the difference was not statistically significant. Conclusion Targeted inhibition of tumor EGFR expression may be a new approach to treating SNSCC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1094–1102, 2014
Prevalence of Developmental Delays and Participation in Early Intervention Services for Young Children

OBJECTIVES. The objective of this study was to use a nationally representative longitudinal sample of children born in the United States in 2001 to estimate rates of eligibility for Part C early intervention, to estimate rates of access to services for developmental delays, and to examine factors that are associated with access to services. METHODS. Data for this study were collected as part of the Early Childhood Longitudinal Study, Birth Cohort, which obtained data from participants when children were 9 and 24 months of age. Descriptive analyses were used to generate national estimates of the prevalence of developmental delays that would make children eligible for Part C services and rates of participation in early intervention services. Logistic regression analyses were conducted to examine whether child developmental delay, race, insurance availability, and poverty status were associated with the probability of receiving services. RESULTS. Results indicated that ∼13% of children in the sample had developmental delays that would make them eligible for Part C early intervention. At 24 months, only 10% of children with delays received services. Children with developmental delays were more likely to receive services than those who do not have delays; black children were less likely to receive services than children from other ethnic and racial groups. CONCLUSIONS. The prevalence of developmental delays that make children eligible for Part C services is much higher than previously thought. Moreover, the majority of children who are eligible for Part C services are not receiving services for their developmental problems. Strategies need to be developed to monitor patterns of enrollment in early intervention services and reach out to more minority children, particularly black children.
On the fundamental role of anatomy in functional imaging: Reply to commentaries on "In praise of tedious anatomy"

We have highlighted the importance of methodological clarity and consistency in the context of anatomical localization, and the commentaries on our target article were largely in agreement with our arguments. Whereas the focus of our target article was on the methodological aspects of anatomical localization, several of the commentaries also highlighted the fact that anatomy is not just about location: The reason that anatomical localization is critical is that anatomy is directly related to multiple aspects of brain function (e.g., Leonard et al., 2006). As a result, accurate, informative reporting of anatomy is a fundamental, but underappreciated, element in functional neuroimaging. We hope that our target article and the associated commentaries will bring renewed attention to this important issue. © 2007 Elsevier Inc. All rights reserved.
Hypoxia Is Not A Cause Of Oxidative Stress In Diabetic Peripheral Nerve

Severe ischemia and hypoxia in the neural tissues are associated with free radical production. The purpose of our study was to explore the contribution of endoneurial hypoxia vs hyperglycemia to oxidative stress in early experimental diabetic neuropathy. This was achieved by evaluating α1-adrenoceptor antagonist prazosin (5 mg/kg in the drinking water, for 3 wks from induction of diabetes), on diabetes-induced changes in endoneurial vascular conductance (VC), biochemical markers of nerve hypoxia, lipid peroxidation and antioxidative defense. Diabetes-induced decrease in VC as well as free NAD+/NADH ratios in mitochondrial cristae, matrix and cytosol, were completely (VC, free NAD+/NADH in mitochondrial matrix) or partially prevented by prazosin. Accumulation of lipid peroxidation products, depletion of GSH, ascorbate and taurine, increase in GSSG/GSH and DHAA/AA ratios were not affected by vasodilator therapy. Antioxidative defense enzyme activities were similar in control and diabetic rats treated with/without prazosin. Blood and nerve glucose concentrations were similarly elevated in prazosin-treated and untreated diabetic rats. In conclusion, hyperglycemia, but not hypoxia, is a major cause of oxidative stress in diabetic peripheral nerve. Free radical production in PNS is dependent on the degree of hypoxia, and is not initiated by relatively mild hypoxia in early diabetes.
Antigen Recognition by Lymphocytes

The immune response represents a collaborative enterprise between various sets of lymphocytes and mononuclear phagocytes. The lymphocytes represent a heterogeneous population grouped into two major sets: The B class, representing the progenitors of antibody-forming cells, and the T or thymic-derived class, which includes various subsets exerting regulatory influences and mediating cellular immune reactions. It has been established, at least for the B cells, that antigen recognition takes place through molecules localized on their plasma membrane. The nature of the receptor molecules and their properties have been reasonably well documented. Controversy exists regarding the receptor for antigen on T lymphocytes. Insofar as the mononuclear phagocytes, it is thought that interaction with antigens takes place by means of various surface “receptors”. Phagocytes have receptors for the Fc piece of IgG and for the third component of complement, enabling them to interact with antigen-antibody complexes; also, phagocytes may bind antigen by way of chemically uncharacterized sites on their surface.
Calcium dynamics of cortical astrocytic networks in vivo.

Large and long-lasting cytosolic calcium surges in astrocytes have been described in cultured cells and acute slice preparations. The mechanisms that give rise to these calcium events have been extensively studied in vitro. However, their existence and functions in the intact brain are unknown. We have topically applied Fluo-4 AM on the cerebral cortex of anesthetized rats, and imaged cytosolic calcium fluctuation in astrocyte populations of superficial cortical layers in vivo, using two-photon laser scanning microscopy. Spontaneous [Ca2+]i events in individual astrocytes were similar to those observed in vitro. Coordination of [Ca2+]i events among astrocytes was indicated by the broad cross-correlograms. Increased neuronal discharge was associated with increased astrocytic [Ca2+]i activity in individual cells and a robust coordination of [Ca2+]i signals in neighboring astrocytes. These findings indicate potential neuron–glia communication in the intact brain.
Voice in Writing Again: Embracing Contraries

Voice used to be a hot critical term in the pages of the journals, but our current scholarly conversation has gone rather quiet. I think there's something to be gained if we reawaken the discussion. Starting around the 1960s, there was a surge of enthusiasm for getting voice into writing. Those of us who were in that surge were not all saying the same thing, but we were all promoting voice in one sense or another: Voice is an important dimension of texts and we should pay lots of attention to it. Everyone has a real voice and can write with power. Writing with a strong voice is good writing. Sincere writing is good writing. My voice is my true self and my rhetorical power. The goal of teaching writing is to develop the self. But then came skeptics. They weren't all saying the same thing either, but they were all being critical in one sense or another: Lefs not pay so much attention to the voice in texts. Voice is a misleading metaphor. We don h write with a "voice " that is ours. We do not write, we are written by our culture. We are socially constructed, and what we mistake for a self is a subject position that changes as we are differentially interpellated from one social context of our life to another. Sincerity is not a useful goal for writing. Interestingly, the enthusiasts and the critics tended to share the same anti-elitist political desire for a fairer and less oppressive society?a desire to give more power to students in the classroom and citizens at large. So, when the skeptical line of
MAVEN: a tool for visualization and functional analysis of genome-wide association results

Summary: We describe the features and implementation of a web application tool named MAVEN—for Management, Analysis, Visualization and rEsults shariNg of genome-wide association data using cutting edge technologies. Main capabilities include user data uploading and management, queries using a variety of criteria, visualization of results, interactive selections and seamless integration of users' data with databases at the National Center for Biotechnology Information (NCBI) for functional annotations of single nucleotide polymorphisms (SNPs) and genes. Availability: http://cbc.case.edu/maven Contact: ude.esac@ilgnij Supplementary information: Supplementary data are available at Bioinformatics online.
Low cost spin coating fabrication of efficient Perovskite thin film layers

Development of fabrication techniques to produce cost efficient Perovskite absorption layers via spin coating techniques using the WS650 spin processor (Laurell Technologies) were investigated. The methyl ammonium lead iodide (CH3NH3PbI3) perovskite was deposited on top of soda lime glass (SLG) substrates. Two ways of depositing CH3NH3PbI3 were explored. The two techniques used to create the perovskite absorption are air drying at 65°C and a solvent-solvent extraction (SSE) method. Rapid processes such as the SSE method will be compared to the air-drying method. Various instruments will be used to characterize the perovskite absorption layer including: Cary 5000 UV-Vis spectrophotometer, and Hitachi S-4800 Scanning Electron Microscope (SEM), the Thermo Scientific DXR SmartRaman spectrometer and Bruker D8 Discover X-Ray Diffraction (XRD). The results were used to evaluate the energy band gap, crystallite size, and crystal structure. Achieving a high quality perovskite layer, while having simple fabrication methods, is the primary focus of this study.
Open source, live CD based, security lab design: tutorial presentation

The tutorial begins with a demonstration of Open Source Software and Live CDs. A Live CD is a bootable Compact Disk (CD) that runs a stand alone operating system (O/S). Generally, Live CDs utilize an Open Source operating system such as Linux. Individual Live CDs may run either from the CD or from RAM.
Differing shades of colour: online dating preferences of biracial individuals

ABSTRACTThe racial and ethnic makeup of the United States has become increasingly diverse over the past few decades. Growing rates of interracial dating and marriage have led to an increasing number of biracial individuals. Despite increasing rates of biracial individuals, research on this population specifically in relation to dating preferences, remains limited in scope. In order to assess biracial individuals' romantic partner preferences, the present research examines 1,203 Internet dating profiles drawn from Match.com. This study utilizes logistic regression to examine the willingness of biracial individuals to cross the colour line when seeking a potential romantic partner. The findings suggest that there are distinct racial dating preferences that reflect the presence of a triracial hierarchy. These results are examined in relation to how identity formation and racial stratification may play a part in shaping the racial/ethnic dating preferences of biracial individuals.
Abstract 1753: High expression of the microtubule destabilizing protein stathmin is prognostic for worse outcome in breast cancer

INTRODUCTION: Taxanes are microtubule targeting agents (MTAs) and potent cytotoxic molecules recognized as highly effective chemotherapeutic agents. In large randomized clinical trials, taxane-based chemotherapies provided benefits in overall and disease-free survival, but they are accompanied by significant adverse effects. Thus the clinical utility of taxane therapy would be enhanced if there were companion diagnostic tests so that only the taxane-sensitive patients (about half of breast cancers) could be treated with this drug. Accumulating evidence indicates that microtubule associated proteins (MAPs) may be responsible for tumor cell resistance to taxanes. Here we use a large retrospective cohort to measure expression levels of stathmin, a microtubule destabilizing protein, and to determine prognostic value, as a first step toward development of a companion diagnostic. METHODS: Stathmin expression was measured in a large retrospective breast cancer cohort (n= 645) with 20 year follow-up using tissue microarray technology (TMA) in two-fold redundancy and quantitative immunofluorescence (AQUA). Patient stathmin expression levels were correlated with clinical, pathological, and disease free survival variables. RESULTS: Stathmin expression exhibited nonparametric distribution with high correlation (R= 0.70) between redundant TMA cores. Prognostic evaluation of the cohort using univariate analysis indicated an inverse correlation between high stathmin expression and overall survival (HR = 1.30, 95% confidence interval [CI] = 1.02-1.65; p CONCLUSIONS: Stathmin expression in breast tumor tissue functions as a prognostic factor where high expression is associated with worse outcome. Since stathmin expression is useful in predicting survival, it may serve as marker to accurately select patients for current taxane-based or other anti-microtubule therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1753.
(α, α'γ) Angular Correlation Studies of Some Excited States in Mg 24 , Mg 26 , and Si 28

A number of states in ${\mathrm{Si}}^{28}$, ${\mathrm{Mg}}^{26}$, and ${\mathrm{Mg}}^{24}$ have been studied using the ($\ensuremath{\alpha}, {\ensuremath{\alpha}}^{\ensuremath{'}}\ensuremath{\gamma}$) reaction and the angular correlation method-II geometry of Litherland and Ferguson. In ${\mathrm{Si}}^{28}$, spin and parity assignments of 1, (${6}^{+}$), and ${1}^{\ensuremath{-}}$ are made to the 7.38-, 8.51-, and 8.94-MeV states, respectively. The 4.90-MeV state in ${\mathrm{Mg}}^{26}$ is assigned ${J}^{\ensuremath{\pi}}={4}^{+}$. Earlier ${J}^{\ensuremath{\pi}}$ assignments to the ${3}^{\ensuremath{-}}$ 6.88-, ${2}^{+}$ 7.41-, and ${2}^{+}$ 7.93-MeV states in ${\mathrm{Si}}^{28}$, and the ${1}^{\ensuremath{-}}$ 8.44-, ${2}^{+}$ 9.00-, and ${1}^{\ensuremath{-}}$ 9.15-MeV states in ${\mathrm{Mg}}^{24}$ are confirmed, as is an earlier value of the multipolarity mixing ratio of the 2.94\ensuremath{\rightarrow}1.81 $\ensuremath{\gamma}$-ray transition in ${\mathrm{Mg}}^{26}$.
Dispersal, Mating, and Oviposition of the Screwworm (Diptera: Calliphoridae) in Southern Mexico

Sterile screwworms, Cochliomyia hominivorax (Coquerel) (strain V-81), released at the mean rate of 868 flies per km2 per week for 3 weeks, imparted only 5% sterility to the native population within 3 km of the center of the release area. No sterile egg masses were collected from artificially wounded sheep at either of two pens located outside the release area (10 km from the nearest ground-release station). Releases at a mean rate of 3,363 flies per km2 per week imparted a mean sterility of 46% at sampling locations at the center of the release area. Although some sterility was detected at one pen outside the release area (5 of 86 masses), differences in proportions of sterility between inside and outside pens were highly significant. Assuming that recaptured flies were representative of the uncaptured and native screwworms and that immigrating fertile females did not contribute substantially to fertility rates within the release site, the distribution of sterile and fertile egg masses and data from trap-back studies supported the hypothesis of limited dispersal of screwworms on the humid tropical coastal plain of southern Mexico during the wet season. I conclude that one can (1) evaluate candidate strains of sterile screwworms and (2) study the bionomics and interactions of native and sterile populations in an efficient and simple manner using the method of ground release of sterile flies.
B-Vitamin Requirements of the Pink Bollworm

The pink bollworm, Pectinophora gossypiella (Saunders), was aseptically reared to determine dietary B-vitamin requirements. Lack of any one of the following vitamins in a casein medium resulted in 100% larval mortality: Calcium pantothenate, folic acid, nicotinamide, pyridoxine, riboflavin, and thiamine. No larvae matured in the absence of biotin in amino acid medium. In a medium of wheat germ without added nicotinamide or calcium pantothenate, complete larval mortality occurred. Larval development with or without vitamin B12 in 3 different media was similar. Quantitative vitamin requirements on casein medium for calcium pantothenate, nicotinamide, riboflavin, thiamine, pyridoxine, and folic acid were 0.40, 0.20, 0.050, <0.050, 0.025, and 0.025mg/ 100g of medium, respectively. Quantitative biotin requirement on amino acid medium was 1 µg /100g of medium.
Nano-catalysts: Key to the Greener Pathways Leading to Sustainability

Copyright: © 2012 Varma RS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Industrial chemistry in the new millennium is widely embracing the concept of “green chemistry” to meet the fundamental scientific challenges of protecting the human health and environment while maintaining commercial success. This emerging area of Green Chemistry is defined as “the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture, and application of chemical products” and envisages minimum hazard as the performance criteria while designing new chemical processes. One of the thrust areas for achieving this target is to explore the generation of efficient catalytic processes, particularly nano-catalysis [1]. The desired approach may encompass alternative activation methodology, such as mechanochemical mixing, photocatalysis, microwave-, and ultrasonic irradiation [2]. Additionally, the strategy has to follow “benign by design” principles and make an effort to utilize renewable resources wherever possible [3].
Application of Human-Computer Interaction Theories to Identify User Requirements for Internet Portal Design

This paper describes the first of two parts of a research study. The overall objective of the research was to determine the effects of tailoring Internet portal content and presentation style to user requirements according to either or both of two HCI theories. This study involved user requirements gathering by using a portal containing hyperlinks as the test bed. Participants rated the hyperlinks according to importance and the descriptions of each hyperlink according to intuitiveness. Results are discussed in terms of user search behavior and specific search requirements.
Sensor-Driven Condition-Based Generator Maintenance Scheduling—Part II: Incorporating Operations

A framework for sensor driven condition based generator maintenance scheduling was proposed in Part I of this paper. In Part II, we extend the previous model by incorporating the unit commitment and dispatch into the optimal maintenance scheduling problem. We reformulate this extended maintenance scheduling problem as a two-stage mixed integer program. We use this reformulation to construct an algorithm that obtains the global optimal solution to the proposed generator maintenance problem. Finally, we test and analyze the proposed model through extensive experiments conducted on IEEE-118 bus system. For every experiment, we present a benchmark analysis against the maintenance models used in current industry practice and power systems literature. Experimental results indicate that the proposed maintenance schedules provide considerable improvements in both cost and reliability.
Metabolic Consequences of Atypical Antipsychotic Drugs

Atypical antipsychotic drugs have become the treatment of choice for psychotic disorders. However, these medications, though certainly superior in many respects to the more traditional medications, have been shown to have a number of untoward consequences. Understanding of the metabolic consequences of these medications is essential for the psychiatrist. The possible development of diabetes, weight gain, and hypertriglyceridemia in patients taking atypical antipsychotics makes it imperative that the prescribing physician regularly monitor patients on these agents. One possible monitoring scheme is outlined and recommendations for treatment are discussed.
Application of Magic Belts on Fixation of Bedside ECG Monitor wire

Electrocardiogram(ECG) monitor is an essential medical equipment in the department of intensive care unit(ICU),which benefits medical staffs' works.But so far the management of monitor wires is still difficult.The fixation of bedside ECG monitor wire by magic belts is not only easy to operate but also reduce wire loss rate and keep beds clean.
A case of CIC-rearranged undifferentiated round-cell sarcoma with exclusive spindled morphology and diffuse CD99 positivity: a potential pitfall

CIC-rearranged sarcomas comprise a recognized subset of the so called “undifferentiated small round cell sarcomas” that lack the traditional EWSR1 fusion to one of the ETS family members.1 A smaller percentage have demonstrated BCOR gene rearrangements.2 The CIC gene is most commonly fused with the DUX4 or DUX4L10 genes through t(4;19)(q35;q13) or t(10;19)(q26;q13). An alternative fusion partner, the FOXO4 (Xq13.1) gene, has recently been identified.3 CIC-rearranged sarcomas have a distinct gene signature compared to classic Ewing sarcomas with upregulation of ETS transcription factors and WT1. They are more common in adults, in soft tissue locations as opposed to bone, and they have a mixed response to neo/adjuvant traditional Ewing sarcoma chemotherapy protocols.4 This article is protected by copyright. All rights reserved.
Relative Effects of Expectancy and Commitment on Salespeople’a Work Outcomes: a Conceptual Framework

Recent research attention to commitment in the selling context needs extreme caution due to the complexity associated with the conceptualization of the construct. This paper clarifies issues associated with typology, measurement, and conceptual distinction between expectancy-based motivation and commitment. In the process, a conceptual framework of the relative effects of expectancy and commitment on salesperson work outcomes is developed and research propositions are generated based on a literature review. Summary and future directions are also provided.
Chapter 7 – Revisiting Computer-Mediated Communication for Work, Community, and Learning

Publisher Summary With more than two decades of computer-mediated communication (CMC) use, it is time to take stock, revisit empirical and theoretical work, and consider its increasingly taken-for-granted use. CMC is also so interconnected with the Internet that cannot be discussed without the other. This chapter highlights the debate about the impact of computer media and the Internet on social interaction. Arguments both for and against CMC focus on the “reduced cues” of the environment, i.e., the way communication is reduced to text-only exchanges, without the additional cues of voice, facial expression, body position, and personal appearance. On the downside, the lack of cues makes CMC ill-suited for conveying confirmatory communication cues. Online communication hampers the ability to convey messages unambiguously and to verify meaning through other communication cues. On the negative side, this can lead to a lack of trust in the exchange and in the relationship with the other person. Individuals have to work harder to make themselves clear, conventions of communication have to be created and adopted between communicators and among online group members. This process can take more time for online than for face-to-face communications.
Functional Behavioral Assessment of Nonverbal Behavior

In this chapter the authors describe how functional behavioral assessment (FBA) procedures can be used to identify the function of various behaviors and the relation between FBAs and related interventions that have successfully reduced inappropriate behaviors. Using the principles of FBA it is possible to identify natural environmental contingencies that maintain the behavior of individuals who lack the verbal skills to communicate information about the function of their behavior (e.g., nonverbal students). These data can then be used to develop interventions based on within-subject data. Although FBA procedures are based on sound theory, the development and evaluation of such procedures is in its infancy and future research is needed to improve the quality of these procedures so that educators can efficiently determine the function of target behaviors. Additionally, combining FBA and treatment effectiveness research may allow researchers to develop function-by-treatment models of linking assessment to intervention, thereby allowing educational professionals to develop more effective prevention and remediation procedures across subjects, based on the assessed function of target behaviors.
Narrating health and scarcity: Guyanese healthcare workers, development reformers, and sacrifice as solution from socialist to neoliberal governance

In oral history interviews, Guyanese healthcare workers emphasize continuity in public health governance throughout the late twentieth century, despite major shifts in broader systems of governance during this period. I argue that these healthcare workers' recollections reflect long-term scarcities and the discourses through which both socialist politicians and neoliberal reformers have narrated them. I highlight the striking similarities in discourses of responsibility and efficiency advanced by socialist politicians in 1970s Guyana and by World Bank representatives designing the country's market transition in the late 1980s, and the ways these discourses have played out in Guyana's health system. Across diverging ideologies, politicians and administrators have promoted severe cost-control as the means to a more prosperous future, presenting short-term pains as necessary to creating new, better, leaner ways of life. In the health sector this has been enacted through a focus on self-help, and on nutrition as a tool available without funds dedicated for pharmaceuticals, advanced medical technologies, or a fully staffed public health system. I argue that across these periods Guyanese citizens have been offered a very similar recipe of ongoing sacrifice. I base my analysis on oral histories with forty-six healthcare workers conducted between 2013 and 2015 in Guyana in Regions 3, 4, 5, 9, and 10, as well as written records from World Bank and Guyanese national archives; I analyze official discourses as well as recollections and experiences of public health governance by those working in Guyana's health system.
Variation in readmission expenditures after high-risk surgery.

Abstract Background The Hospital Readmissions Reduction Program reduces payments to hospitals with excess readmissions for three common medical conditions and recently extended its readmission program to surgical patients. We sought to investigate readmission intensity as measured by readmission cost for high-risk surgeries and examine predictors of higher readmission costs. Materials and methods We used the Healthcare Cost and Utilization Project's State Inpatient Database to perform a retrospective cohort study of patients undergoing major chest (aortic valve replacement, coronary artery bypass grafting, lung resection) and major abdominal (abdominal aortic aneurysm repair [open approach], cystectomy, esophagectomy, pancreatectomy) surgery in 2009 and 2010. We fit a multivariable logistic regression model with generalized estimation equations to examine patient and index admission factors associated with readmission costs. Results The 30-d readmission rate was 16% for major chest and 22% for major abdominal surgery (P 3 wk after discharge was associated with lower costs among abdominal surgery patients. Conclusions Readmissions after high-risk surgery are common, affecting about one in six patients. Predictors of higher readmission costs differ among major chest and abdominal surgeries. Better identifying patients susceptible to higher readmission costs may inform future interventions to either reduce the intensity of these readmissions or eliminate them altogether.
Multifunctional glial support by Semper cells in the Drosophila retina

Glial cells play structural and functional roles central to the formation, activity and integrity of neurons throughout the nervous system. In the retina of vertebrates, the high energetic demand of photoreceptors is sustained in part by Muller glia, an intrinsic, atypical radial glia with features common to many glial subtypes. Accessory and support glial cells also exist in invertebrates, but which cells play this function in the insect retina is largely undefined. Using cell-restricted transcriptome analysis, here we show that the ommatidial cone cells (aka Semper cells) in the Drosophila compound eye are enriched for glial regulators and effectors, including signature characteristics of the vertebrate visual system. In addition, cone cell-targeted gene knockdowns demonstrate that such glia-associated factors are required to support the structural and functional integrity of neighboring photoreceptors. Specifically, we show that distinct support functions (neuronal activity, structural integrity and sustained neurotransmission) can be genetically separated in cone cells by down-regulating transcription factors associated with vertebrate gliogenesis (pros/Prox1, Pax2/5/8, and Oli/Olig1,2, respectively). Further, we find that specific factors critical for glial function in other species are also critical in cone cells to support Drosophila photoreceptor activity. These include ion-transport proteins (Na/K+-ATPase, Eaat1, and Kir4.1-related channels) and metabolic homeostatic factors (dLDH and Glut1). These data define genetically distinct glial signatures in cone/Semper cells that regulate their structural, functional and homeostatic interactions with photoreceptor neurons in the compound eye of Drosophila. In addition to providing a new high-throughput model to study neuron-glia interactions, the fly eye will further help elucidate glial conserved "support networks" between invertebrates and vertebrates.
On Exploiting Structured Human Interactions to Enhance Sensing Accuracy in Cyber-physical Systems

In this article, we describe a general methodology for enhancing sensing accuracy in cyber-physical systems that involve structured human interactions in noisy physical environment. We define structured human interactions as domain-specific workflow. A novel workflow-aware sensing model is proposed to jointly correct unreliable sensor data and keep track of states in a workflow. We also propose a new inference algorithm to handle cases with partially known states and objects as supervision. Our model is evaluated with extensive simulations. As a concrete application, we develop a novel log service called Emergency Transcriber, which can automatically document operational procedures followed by teams of first responders in emergency response scenarios. Evaluation shows that our system has significant improvement over commercial off-the-shelf (COTS) sensors and keeps track of workflow states with high accuracy in noisy physical environment.
App Review: Management Guide for Incidental Findings on CT and MRI

While the user should read and understand the relevant ACR white papers thoroughly, so that subtleties are not lost, the app is an efficient, easy to use, and free resource for managing a wide variety of incidental findings encountered on CT or MRI.
Evaluating the solvation properties of metal-containing ionic liquids using the solvation parameter model

Ionic liquids (IL) have been utilized as gas chromatography stationary phases due to their high thermal stability, negligible vapor pressure, wide liquid range, and the ability to solvate a range of analytes. In this study, the solvation properties of eight room temperature ILs containing various transition and rare earth metal centers [e.g., Mn(II), Co(II), Ni(II), Nd(III), Gd(III), and Dy(III)] are characterized using the Abraham solvation parameter model. These metal-containing ILs (MCILs) consist of the trihexyl(tetradecyl)phosphonium cation and functionalized acetylacetonate ligands chelated to various metals. They are used in this study as gas chromatographic stationary phases to investigate the effect of the metal centers on the separation selectivities for various analytes. In addition, two MCILs comprised of tetrachloromanganate and tris(trifluoromethylphenylacetylaceto)manganate anions were used to study the effect of chelating ligands on the selectivity of the stationary phases. Depending on the metal center and chelating ligand, significant differences in solvation properties were observed. MCILs containing Ni(II) and Mn(II) metal centers exhibited higher retention factors and higher peak asymmetry factors for amines (e.g., aniline and pyridine). Alcohols (e.g., phenol, p-cresol, 1-octanol, and 1-decanol) were strongly retained on the MCIL stationary phase containing Mn(II) and Dy(III) metal centers. This study presents a comprehensive evaluation into how the solvation properties of ILs can be varied by incorporating transition and rare earth metal centers into their structural make-up. In addition, it provides insight into how these new classes of ILs can be used for solute-specific gas chromatographic separations.
Full Scope-of-Practice Regulation Is Associated With Higher Supply of Nurse Practitioners in Rural and Primary Care Health Professional Shortage Counties

Introduction Access to quality primary care is challenging for rural populations and individuals residing in primary care health professional shortage areas (HPSAs). The ability of nurse practitioners (NPs) to provide full care is governed by state scope-of-practice (SOP) regulation, which is classified into three types: full SOP, reduced SOP, and restricted SOP. Understanding how legislative and regulatory decisions can influence supply of NPs in underserved areas can help guide effective health policies to reduce disparities in access to care. Objective To investigate the trends in NP supply in rural and primary care HPSA counties and their relationship with SOP regulation. Methods The authors conducted longitudinal data analyses using an integrated county-level national data set from 2009 to 2013. A hierarchical mixed-effects model was performed to assess the relationship between state SOP regulation and NP supply in rural and primary care HPSA counties. Results The number of NPs per 100,000 population increased in rural and primary care HPSA counties across states with various types of SOP regulation between 2009 and 2013. Compared with the NP supply in rural or primary care HPSA counties in states with reduced or restricted SOP regulation, NP supply in those counties in states with full SOP regulation was statistically significantly higher. Conclusions State full SOP regulation was associated with higher NP supply in rural and primary care HPSA counties. Regulation plays a role in maximizing capacity of the NP workforce in these underserved areas, which are most in need for improvement in access to care. This information may help inform state regulatory policies on NP supply, especially in underserved areas.
Intrathecal spinal abscesses due to Candida albicans in an immunocompetent man

Infections of the central nervous system due to Candida albicans are uncommon and are usually only observed in special circumstances, such as following neurosurgery or penetrating head trauma, in immunosuppressed patients, premature infants or in patients with ventriculoperitoneal shunts. The author reports a case of an immunocompetent man who presented with a thoracic intraspinal abscess due to C. albicans. Despite surgical drainage and 6 weeks of high-dose fluconazole therapy, the abscess extended and recurred in the cervical spine, requiring a second operation to arrest the infection.
A Written Constitution Without Functioning Constitutionalism – Analysis of Xi Jinping's 2012 Speech on Chinese Constitution

This paper examines the 2012 speech by Chinese President Xi Jinping at the Great Hall of the People (the national parliament building) marking the 30th anniversary of the adoption of the current version of the Constitution of the People’s Republic of China. While Xi’s speech formally functions in an epideictic capacity, its substantive content suggests a severely flawed constitutional system. Through the close analysis of the speech, this paper argues that the text of Xi’s address exposes many critical tensions intrinsic to China’s single-party political system, most notably the flawed implementation of the constitution. In its substantive capacity, the speech served as a stern warning about the gaping chasm that separates the written constitution from actual political practices in China, as well as the pressing need to formalize the Party-state relationship through the separation of powers between the Party and the state.
The weak psuedoscalar coupling of the free and the bound protons

The proton`s weak pseudoscalar coupling, g{sub p} is induced by the effects of its strong interaction on its weak interaction. In the Partially Conserved Axial Current hypothesis g{sub p} is due to single pion exchange between the leptonic and nucleonic currents in semi-leptonic weak processes. It predicts g{sub p} = 8.4 {plus_minus} 0.2 for the free proton but modifications of g{sub p}for the bound proton, due to modifications of the pion field of the bound proton, are possible. We will review the available data on g{sub p} for both the free and the bound proton. In the case of the free proton g{sub p} has been determined from measurements of ordinary (OMC) and radiative muon capture (RMC) on hydrogen. We will discuss the extraction of g{sub p} from the data, the importance of various {mu}-atomic and molecular processes in extracting g{sub p }and compare the results obtained from the OMC and RMC data and experiments in gaseous and liquid H{sub 2}. In the case of the bound proton we will discuss the measurements of ordinary and radiative {mu}{sup -} capture on complex nuclei and the extraction of g{sub p} from these data. The comparison of inclusive RMC and OMC ratesmore » on nuclei has led to speculations of a large enhancement of g{sub p} in light nuclei and a large quenching of g{sub p} in heavy nuclei. We will discuss the evidence for and against the renormalization, of g{sub p}in nuclei and the problems of extracting g{sub p} from the nuclear RMC and OMC data.« less