cssi/SciSciGPT-SciSciNet huggingface dataset:
Abstract 1130: Targeting the tumor-associated autoantigen alpha-enolase in prostate cancer

Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause of cancer-related deaths in American men. African American (AA) men are more likely to be diagnosed with aggressive PCa at a younger age and twice as likely to die from the disease as European American (EA) men. In order to reduce PCa mortality and its associated racial disparities, there is a critical need to identify and target pathways responsible for PCa aggressiveness. An unexplored target is the plasminogen system, which is key to cancer cell migration and tissue invasion during metastasis. During inflammation, activation of the plasminogen pathway degrades extracellular fibrin networks; however, in the context of cancer, this activation promotes cancer tissue invasion and metastasis. Mounting evidence shows that the glycolytic enzyme alpha-enolase (ENO1) plays a vital role in both increased energy metabolism and plasminogen activation during cancer progression and metastasis. Using immunoseroproteomic profiling of anti-tumor autoantibody responses in AA and EA men with PCa, we identified several tumor-associated autoantigens with functions in glycolysis and plasminogen signaling, including ENO1, annexin A2, fructose bisphosphate aldolase, glucose-regulated protein 78, glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase. In a cohort of PCa (N=157) and non-PCa sera (N=183), we found a significantly higher frequency of autoantibodies to ENO1 in patients with PCa (p Citation Format: Tino Wilson Sanchez, Guangyu Zhang, Jitian Li, Liping Dai, Saied Mirshahidi, Nathan R. Wall, Clayton Yates, Colwick Wilson, Susanne Montgomery, Jian-Ying Zhang, Carlos A. Casiano. Targeting the tumor-associated autoantigen alpha-enolase in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1130. doi:10.1158/1538-7445.AM2017-1130
Linear Functions with Two Points of Intersection

We need to check our X-range f course two straight lines in Euclidean space cannot intersect in more than one point unless they are the same line and intersect everywhere?or can they? Follow this problem on the graphing calculator, however, and the surprising twist that gives this article its name will be seen. The material covered should be readily accessible to first-year-algebra students who have studied systems of equations, but it also contains valuable lessons for college mathematics professors who have been easily deceived by its apparent simplicity and familiarity. Consider this problem, which leads to a system of linear equations:
The modified j-pole: A wideband end-fed half-wave dipole for a VHF reflector feed system

A “J-pole” is a 3λ/4-long dipole-type antenna that can be end-fed and does not require a ground plane or radials. This paper describes a modification to the classical J-pole which reduces the length to about λ/2. While this results in directivity about 0.5 dB less than an ideal half-wave dipole, the fractional bandwidth is increased to about 40% for |s 11 < −10 dB (50Ω). The use of this antenna as part of a new supplementary VHF-band feed system for an existing reflector antenna is described.
Identifying the foci of mission statements of the zoo and aquarium community

Zoos and Aquariums are increasingly being called upon to engage in conservation education to advance conservation goals and justify the keeping of captive animals. Further, the Association of Zoos ...
Preservice teachers’ racialized emotion recognition, anger bias, and hostility attributions

Abstract Differential treatment of students by race is well documented, and potentially driven by implicit processes relating to racial prejudice. To better understand some of the pathways by which racial prejudice may be activated, we examined preservice teachers’ racialized perceptions specific to emotion. Forty preservice teachers identified the emotions expressed in 20 Black and White male and female faces in order to assess racialized emotion accuracy and anger bias; participants also judged hostility in videos of 4 Black and White boys’ misbehaviors with peers in school in order to assess racialized attributions. We conducted a series of multilevel models with assessments of Black and White faces (or boys) nested within preservice teachers. Results indicated that emotions in Black faces were less accurately recognized than emotions in White faces; Black faces were more likely to be seen as angry even when they were not, compared to White faces; and boys’ misbehaviors were perceived as more hostile than those of White boys. Together, these results consistently suggest that racialized emotion-related perceptions may enter the classroom with preservice teachers. Implications, as well as limitations that may be resolved in future studies, and extensions of these findings to other minority status populations are discussed.
Advances in Sensitivity Analysis of Uncertainty to Changes in Sampling Density When Modeling Spatially Correlated Attributes

A comparative analysis of distance methods, kriging and stochastic simulation is conducted for evaluating their capabilities for predicting fluctuations in uncertainty due to changes in spatially correlated samples. It is concluded that distance methods lack the most basic capabilities to assess reliability despite their wide acceptance. In contrast, kriging and stochastic simulation offer significant improvements by considering probabilistic formulations that provide a basis on which uncertainty can be estimated in a way consistent with practices widely accepted in risk analysis. Additionally, using real thickness data of a coal bed, it is confirmed once more that stochastic simulation outperforms kriging.
Formulating and Solving Nonlinear Programs as Mixed Complementarity Problems

We consider a primal-dual approach to solve nonlinear programming problems within the AMPL modeling language, via a mixed complementarity formulation. The modeling language supplies the first order and second order derivative information of the Lagrangian function of the nonlinear problem using automatic differentiation. The PATH solver finds the solution of the first order conditions which are generated automatically from this derivative information. In addition, the link incorporates the objective function into a new merit function for the PATH solver to improve the capability of the complementarity algorithm for finding optimal solutions of the nonlinear program. We test the new solver on various test suites from the literature and compare with other available nonlinear programming solvers.
Metal Cluster Beams and Electron Diffraction: Deviations from the Bulk States of Matter

The salient features of cluster production are outlined and several specific cluster beam sources presented. The mean cluster size is seen to be dependent on oven temperature, related to the evaporation rate; the carrier gas pressure, related to the metal cooling and diffusion rate away from the evaporating surface; the carrier gas temperature, related to the metal vapor cooling rate; and on the carrier gas molecular weight, related to the metal-carrier gas collision cross section and therefore to the energy and mass transport processes.
Nietzsche Among the Neo-Kantians; Or, the Relation Between Science and Philosophy

Can one really speak of Nietzsche “among” the neo-Kantians? Even if we adopt the very inclusive narrative of neo-Kantianism developed in Kohnke’s history of the movement, we find its adherents taking scant notice of Nietzsche during his productive years.1 In the 1870s, when neo-Kantianism was establishing itself as the leading current in academic philosophy, only one reference to Nietzsche’s work by a neo-Kantian appears in the literature, a reference to Der Geburt der Tragodie in the second edition (1873) of F. A. Lange’s Geschichte des Materialismus.2 In the 1880s there was hardly more discussion of Nietzsche among members of the diverse movement. In an 1880 letter to Tonnies, Paulsen noted that with Menschliches-Allzumenschliches Nietzsche had “gone from metaphysics right over into positivism,”3 but there are no published notices by neo-Kantian philosophers. Looking back at this period from the standpoint of his 1920 critique of Lebensphilosophie, Heinrich Rickert claimed to have read the first three parts of Zarathustra as a young student in the summer of 1886, when “Nietzsche was entirely unknown,” and from then on “read every line of his that I could get my hands on.”4 Also looking back from the perspective of the 1920s, Paul Natorp recalled that during the “Kaiserzeit” (Krummel suggests that this would be after his Habilitation in 1881) the threat lay not in “naturalism and empiricism,” then already in principle overcome by the neo-Kantians, but in the “self-deception, nourished above all by Nietzsche, of the individual’s immediate grasp of self-lived life, aiming to transcend both reason and experience in the height of the moment”5 — but a genuine encounter with Nietzsche did not take place.
1H, 15N, and 13C resonance assignments for the N-terminal 20 kDa domain of the DNA single-strand break repair protein XRCC1.

XRCC1 is a 633-residue protein necessary for the repair of single-strand DNA breaks in mammalian cells. The XRCC1 protein has three apparent domains that include the N-terminal 20 kDa domain, a central BRCT domain, and a C-terminal BRCT domain. Two intervening segments of the XRCC1 protein have not been classified. Chinese hamster ovary cell lines with mutations in the XRCC1 gene have characteristic DNA repair defects that include sensitivity to ionizing radiation, elevated levels of single-strand DNA breaks, and increased sister chromatid exchange (Thompson et al., 1990; Shen et al., 1998). Using methods that included affinity chromatography and yeast two-hybrid screening, the XRCC1 N-terminal domain and intact XRCC1 were shown to interact with mammalian β-Pol (Kubota et al., 1996). The C-terminal BRCT domain interacts with a BRCT domain in DNA ligase III. The central BRCT domain of XRCC1 has been shown to interact with a BRCT domain on PARP (Masson et al., 1998). Thus, the XRCC1 protein has been considered to be a scaffolding protein, necessary for formation of a βPol-XRCC1-DNA ligase III repair complex, and this complex may also interact with PARP. No structural information is available for the XRCC1 N-terminal domain. Here we report on the 1H, 15N, and 13C res∗To whom correspondence should be addressed. E-mail: gmullen@panda.uchc.edu Abbreviations: XRCC1, X-ray cross-complementing group 1 protein; β-Pol, DNA polymerase β; BER, base excision repair; BRCT, BRCA1 (breast cancer susceptibility protein) C-terminal domain; PARP, poly(ADP-ribose) polymerase; IPTG, isopropyl β-D-thiogalactopyranoside; AEBSF, 4-(2-aminoethyl)benzenesulfonylfluoride; DTT, dithiothreitol. onance assignments for the backbone and essentially all side chains within the XRCC1 20 kDa N-terminal domain.
Orbital arteriovenous fistula presenting with choroidal pulsations on optical coherence tomography.

Abstract Purpose To describe a case of orbital arteriovenous fistula diagnosed based on choroidal pulsations on optical coherence tomography (OCT). Observations A 69-year-old female originally referred for evaluation of macular degeneration. During acquisition of OCT images, choroidal pulsations of the right eye were noted on the B-scan on the instrument display. The pulsations were not noted on gross or funduscopic examination. Fluorescein angiography was unremarkable. Indocyanine green angiography revealed engorged choroidal vasculature in the right eye. OCT angiography revealed relative tortuosity and dilation of the superficial and deep vascular complexes respectively. B-scan ultrasonography revealed orbital pulsations on the right. MRI imaging of the brain and orbits was unremarkable. Findings were attributed to a low-flow orbital arteriovenous fistula. The patient subsequently developed mild stasis retinopathy for which anti-VEGF therapy was initiated. Conclusions and importance Arteriovenous fistulas of the brain and orbit classically present with gross pulsatile proptosis among other clinical features. Low flow orbital fistulas may present with subtle choroidal pulsations only detectable on OCT.
High-flow versus standard nasal cannula in morbidly obese patients during colonoscopy: A prospective, randomized clinical trial.

Abstract Study objective Morbid obesity is associated with adverse airway events including desaturation during deep sedation. Prior works have suggested that proprietary high-flow nasal cannula devices generate positive pressure to all airway structures and may be superior to standard (low-flow) nasal cannula for prevention of desaturation. We hypothesized that, at a similar fraction of inspired oxygen (FiO2), use of a High-Flow Nasal Cannula (HFNC) at maximum flow rate would result in a lower incidence of intra-procedural desaturation episodes in morbidly obese patients compared to standard nasal cannula (SNC) during deep sedation with propofol. Design This is a pragmatic, prospective, randomized clinical trial at one hospital ( NCT03148262 , UTSW#112016-058). Morbidly obese patients were randomized to HFNC during propofol sedation for colonoscopy. HFNC was performed using maximum flow rates of 60 liters per minute (LPM) and FiO2 of 0.36–0.40, whereas SNC was performed at 4LPM. The primary endpoint was incidence of arterial oxygen desaturation Main results Patients were randomized to HFNC (n = 28) or SNC (n = 31). Interim analysis of the primary endpoint showed that the desaturation rates in the HFNC group (39.3%) and the SNC group (45.2%) were not significantly different (p = 0.79). The DMC halted the trial at that point due to futility. Conclusion At similar FiO2, HFNC was not significantly different from SNC for prevention of arterial oxygen desaturation in morbidly obese patients undergoing propofol sedation for colonoscopy.
Edge-to-Edge Repair of the Mitral Valve with the Mitraclip System: Evolution of Leaflet Grasping Technology

The first cases with the MitraClip system (Abbott, Menlo Park, CA) were performed by Dr. Jose Condado in June 2003, followed by Ted Feldman in the United States in July 2003. Recalling our first ca...
Are Domestic Abusers Terrorists: Rhetoric, Reality, and Asylum Law

The terms terrorism and terrorist are highly charged but all too often imprecisely utilized in legal, media, and political arenas. The terminology has even entered the field of intimate partner violence, where the phrases terrorism in the home or intimate terrorism have been used to describe domestic abuse. This language has proliferated not only due to identified commonalities between intimate partner abuse and terroristic behaviors but also because of the rhetorical impact of the words in highlighting the gravity of domestic violence. However, expanding the legal framework of terrorism into new areas has potentially serious and far-reaching consequences. It is therefore critical to carefully analyze the impact of reconceptualizing intimate partner abuse as a form of terrorism. This Article undertakes such an analysis with a focus on asylum law. It ultimately concludes that even though reconceptualizing intimate partner abuse as terrorism in the home may accurately describe the political and societal implications of domestic abuse (as well as the state’s complicity in perpetuating it) and has the potential to expand access to asylum for survivors, the terrorist label should be applied with caution. The decision to designate a violent act a terrorist act is often political in nature, and race and religious affiliation are frequently decisive factors in assigning the label. Moreover, significant criminal and immigration consequences exist for those who are either branded terrorists or those who harbor or materially support terrorists, potentially including survivors themselves. Recognizing these drawbacks, this Article calls for selective and limited use of the intimate terrorism framework –– effectively defining the phenomenon without utilizing the label –– in the asylum law system.
Reproducibility and Changes in Vena Caval Blood Flow by Using 4D Flow MRI in Pulmonary Emphysema and Chronic Obstructive Pulmonary Disease (COPD): The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Substudy

BackgroundChronic obstructive pulmonary disease (COPD) is associated with hemodynamic changes in the pulmonary vasculature. However, cardiac effects are not fully understood and vary by phenotype of chronic lower respiratory disease.PurposeTo use four-dimensional (4D) flow MRI for comprehensive assessment of the right-sided cardiovascular system, assess its interrater and intraobserver reproducibility, and examine associations with venous return to the right heart in individuals with chronic COPD and emphysema.Materials and MethodsThe Multi-Ethnic Study of Atherosclerosis COPD substudy prospectively recruited participants who smoked and who had COPD and nested control participants from population-based samples. Electrocardiography and respiratory gated 4D flow 1.5-T MRI was performed at three sites with full volumetric coverage of the thoracic vessels in 2014-2017 with postbronchodilator spirometry and inspiratory chest CT to quantify percent emphysema. Net flow, peak velocity, retrograde flow, and retrograde fraction were measured on 14 analysis planes. Interrater reproducibility was assessed by two independent observers, and the principle of conservation of mass was employed to evaluate the internal consistency of flow measures. Partial correlation coefficients were adjusted for age, sex, race/ethnicity, height, weight, and smoking status.ResultsAmong 70 participants (29 participants with COPD [mean age, 73.5 years ± 8.1 {standard deviation}; 20 men] and 41 control participants [mean age, 71.0 years ± 6.1; 22 men]), the interrater reproducibility of the 4D flow MRI measures was good to excellent (intraclass correlation coefficient range, 0.73-0.98), as was the internal consistency. There were no statistically significant differences in venous flow parameters according to COPD severity (P > .05). Greater percent emphysema at CT was associated with greater regurgitant flow in the superior and inferior caval veins and tricuspid valve (adjusted r = 0.28-0.55; all P < .01), particularly in the superior vena cava.ConclusionFour-dimensional flow MRI had good-to-excellent observer variability and flow consistency. Percent emphysema at CT was associated with statistically significant differences in retrograde flow, greatest in the superior vena cava.© RSNA, 2019Online supplemental material is available for this article.See also the editorial by Choe in this issue.
Extraction and visualization of orientation data from virtual geologic surfaces with MATLAB

High-resolution visualization of surfaces of geologic interest, at a multitude of scales, using 3D point cloud technologies provides an opportunity to analyze spatial relationships of surfaces using orientation data. We present a MATLAB® script that produces planar geologic attitude data (e.g., strike, dip, and dip-direction data) from 3D datasets (e.g., point clouds, 3D scanning). The method utilizes Cartesian coordinates of triangular planar surfaces and converts them into matrices of conventional geologic attitude data. Spatial relationships among data points can be investigated, using polar tangent diagrams, stereographic analysis, or geologic curvature analysis. We utilize this script to create "synthetic" graphical plots (e.g., stereograms, tangent diagrams) from geomechanically realistic, virtual, folded surfaces produced by dynamic modeling. Synthetic graphical diagrams are of considerable usefulness in interpreting graphical plots (e.g., stereograms) of attitude data from natural folded rock surfaces, particularly in locations with poor exposure. •This script outputs attitude data (strike, dip, and dip direction) in a spreadsheet and as a text file for use in other visualization software.•A tangent diagram is created and displayed in this script for rapid visualization and fold shape assessment.•The MATLAB script is readily modified to accept multiple data formats for input (e.g., MATLAB variables, *.csv files, etc.) and output (e.g., *.csv files, *.txt files, etc.).
Genetic risk assessment and haemoglobinopathy counselling: two case studies

Background The author works as an antenatal and newborn (ANNB) screening coordinator in a hospital designated as an area of low prevalence for sickle cell and thalassaemia (SCT). As such, the oppor...
Longitudinal Assessment of Quadriceps Muscle Morphology Before and After Anterior Cruciate Ligament Reconstruction and Its Associations With Patient-Reported Outcomes:

Background:Reductions in muscle size are common after anterior cruciate ligament reconstruction (ACLR) and may contribute to suboptimal patient outcomes. However, few studies have quantified postop...
Comparison of post-operative pain scores and opioid use between kyphoplasty and radiofrequency ablation (RFA) systems combined with cement augmentation

This retrospective chart review study aims to compare demographic information, post-operative pain scores, and opioid use following treatment with kyphoplasty alone, OsteoCool™ (Medtronic) system, and SpineSTAR ® (Merit Medicine). Following institutional review board approval, retrospective chart review of 64 patients was examined between January 2011 and December 2017. Inclusion criteria for this study comprised patients greater than 18 years old having metastatic vertebral compression fracture involving the thoracolumbar spine. Exclusion criteria consisted of non-pathologic osteoporotic compression fractures, metastasis in cervical spine, or previous radiofrequency ablation (RFA) treatment. Age at intervention, gender, previous treatment, and nursing recorded VAS score from 0 to 10, with zero representing no pain and 10 representing worst pain were compared. Pain scores documented immediately pre- and post-operatively, as well as 7–14 days post-operatively were targeted for analysis. Post-procedure opioid intake during the first month following surgery was also assessed. A total of 63 patients were included in this retrospective analysis. The demographic characteristics between the treatment arms were similar. Difference of square means analysis showed no statistical difference in pain scores at each time interval between the two RFA systems, or was there a statistical difference in pain scores when each RFA system was compared independently to kyphoplasty alone. Chi-squared analysis showed no statistical difference in opioid use between the treatment arms 1 month post-operatively. To our knowledge, this is the first study that evaluates post-operative pain scores between the two novel RFA systems and kyphoplasty alone. Each system results in improved pain scores post-operatively; however, no additional benefit was seen from the addition of RFA.
Investigating molecular-level factors that affect the durability of restored aged asphalt binder

Abstract This paper examines the durability of restored aged asphalt in terms of its susceptibility to moisture and aging. The study is motivated by the increasing use of modifiers called rejuvenators that are added to paving mixtures containing reclaimed asphalt pavements to restore the original rheological properties of asphalt binder that have been lost during service life. Although several test methods have been proposed to quantify the restoration capability of rejuvenators, not much attention has been given to the side-effects that the rejuvenators may impart to the resulting mix. Due to the specific chemical composition of certain rejuvenators, they may negatively impact the durability of the mixture, especially pertaining to its resistance to moisture damage and aging. This paper examines several rejuvenators that are all effective at restoring aged asphalt binder’s rheological properties, to highlight plausible side effects that may be overlooked when selection criteria are based solely on the restoration capacity of rejuvenators. Our laboratory experiments and computational analysis geared toward the use of rheometry and density functional theory showed that while all studied rejuvenators restored the rheological properties of aged asphalt binders, they had very different durability in terms of resistance to aging and moisture damage. Results obtained from the dynamic shear rheometer showed the rejuvenators with the highest restoration capacity did not have the best durability. Computational analysis showed that while the restoration capacity of rejuvenators is related to their penetration into and peptizing of asphaltene nanoaggregates, durability is mainly related to their polarizability values. Rejuvenators with lower polarizability showed better resistance to aging and moisture damage. The outcome of the study facilitates production of effective rejuvenators without compromising the long-term durability of restored asphalt binder. It also helps road authorities develop selection metrics that account for durability along with rheological properties, to prevent non-durable rejuvenators from entering the market. Accordingly, the study results promote sustainability and resource conservation by providing an in-depth understanding of the relation between rejuvenators’ chemical structure and the durability of restored aged asphalt binder.
Electrospun PLGA and β-TCP (Rebossis-85) in a Lapine Posterolateral Fusion Model.

Background Calcium phosphate materials have been employed clinically as bone void fillers for several decades. These materials are most often provided in the form of small, porous granules that can be packed to fill the wide variety of size and shape of bony defects encountered. ReBOSSIS-85 (RB-85) is a synthetic bioresorbable bone void filler for the repair of bone defects with handling characteristics of glass wool-like (or cotton ball-like). The objective of this study is to evaluate the in vivo performance of RB-85 (test material), compared to a commercially available bone void filler, Mastergraft Putty (predicate material), when combined with bone marrow aspirate and iliac crest autograft, in an established posterolateral spine fusion rabbit model. Methods One hundred fifty skeletally mature rabbits had a single level posterolateral fusion performed. Rabbits were implanted with iliac crest bone graft (ICBG), Mastergraft Putty™ plus ICBG, or one of 4 masses of ReBOSSIS-85 (0.2, 0.3, 0.45, or 0.6 g) plus ICBG. Plain films were taken weekly until euthanasia. Following euthanasia at 4, 8, and 12 weeks, the lumbar spine were tested by manual palpation. Spinal columns in the 12 week group were also subjected to non-destructive flexibility testing. MicroCT and histology were performed on a subset of each implant group at each euthanasia period. Results Radiographic scoring of the fusion sites indicated a normal healing response in all test groups. Bilateral radiographic fusion rates for all test groups were 0% at 4 weeks; ICBG 43%, Mastergraft Putty 50%, RB-85-0.2g 0%, RB-85-0.3g 13%, RB-85-0.45g 38%, and RB-85-0.6g 63% at 8 weeks; and ICBG 50%, Mastergraft Putty 50%, RB-85-0.2g 0%, RB-85-0.3g 25%, RB-85-0.45g 36%, and RB-85-0.6g 50% at 12 weeks.Spine fusion was assessed by manual palpation of the treated motion segments. At 12 weeks, ICBG, MGP, and RB-85-0.6g were fused mechanically in at least 50% of the rabbits. All groups demonstrated significantly less range of motion in both flexion/extension, lateral bending, and axial rotation compared to normal unfused controls.Histopathology analysis of the fusion masses, in all test groups, indicated an expected normal response of mild inflammation with macrophage and multinucleated giant cell response to the graft material at 4 weeks and resolving by 12 weeks. Regardless of test article, new bone formation and graft resorption increased from 4 to 12 weeks post-op. Conclusions This animal study has demonstrated the biocompatibility and normal healing features associated with the ReBOSSIS-85 bone graft (test material) when combined with autograft as an extender. ReBOSSIS-85 was more effective when a larger mass of test article was used in this study. Clinical relevance ReBOSSIS-85 can be used as an extender negating the need for large amounts of local or iliac crest bone in posterolateral fusions.
Witnessing the archive: Stormé DeLarverie and queer performance historicity

This essay animates witnessing as method to engage the performance historicity constellating the photographic archive of Storme DeLarverie (1920–2014). The archive resists historical white represen...
Enhancing Integrative Cognitive-Affective Therapy with ecological momentary interventions: A pilot trial.

Objective Although current treatments are effective for some patients with eating disorders, a large number of patients remain partially or fully symptomatic post-treatment. This may be related to poor utilization of treatment skills outside of the therapy office. Smartphone applications that can detect and intervene during moments of need could facilitate such skill use between sessions. Method Individuals (N = 16) participated in a small pilot open trial where they received 21 sessions of in-person Integrative Cognitive-Affective Therapy (ICAT) therapy an app (iCAT+) that delivers ecological momentary interventions (EMI) in response to user-entered data. Data were collected on the feasibility and acceptability of this treatment approach and on preliminary indicators of treatment outcomes. Results Participants found iCAT+ as a treatment augmentation acceptable and indicated it had clinical utility as an adjunct to in-person therapy, although analyses indicated poor compliance with data entry needed to trigger EMI delivery. This suggests that long-term use of EMI requiring ongoing data entry is infeasible. Conclusions We describe lessons learned from our initial pilot trial and future directions for the development of impactful EMI systems that can be used to augment in-person therapies.
Facial Nerve Repair: Bioengineering Approaches in Preclinical Models

Injury to the facial nerve can occur after different etiologies and range from simple transection of the branches to varying degrees of segmental loss. Management depends on the extent of injury and options include primary repair for simple transections and using autografts, allografts, or conduits for larger gaps. Tissue engineering plays an important role to create artificial materials that are able to mimic the nerve itself without extra morbidity in the patients. The use of neurotrophic factors or stem cells inside the conduits or around the repair site is being increasingly studied to enhance neural recovery to a greater extent. Preclinical studies remain the hallmark for development of these novel approaches and translation into clinical practice. This review will focus on preclinical models of repair after facial nerve injury to help researchers establish an appropriate model to quantify recovery and analyze functional outcomes. Different bioengineered materials, including conduits and nerve grafts, will be discussed based on the experimental animals that were used and the defects introduced. Future directions to extend the applications of processed nerve allografts, bioengineered conduits, and cues inside the conduits to induce neural recovery after facial nerve injury will be highlighted.
The laboratory diagnosis of platelet disorders: An algorithmic approach

○ Objective.-To provide both a detailed description of the laboratory tests available in the diagnosis of platelet disorders and a testing algorithm, based on platelet count, that can be used to direct the evaluation of platelet disorders. Data Sources.-A literature search was conducted using the National Library of Medicine database. Study Selection.-The literature on laboratory testing of platelet function was reviewed. Data Extraction and Data Synthesis.-Based on the literature review, an algorithm for platelet testing was developed. Conclusions.-A history of mucocutaneous bleeding often indicates abnormal platelet function that can be associated with a normal, increased, or decreased platelet count. Multiple laboratory procedures can now be used to determine the underlying pathologic condition of platelet dysfunction when other deficiencies or defects of the coagulation cascade or fibrinolysis are ruled out. Simple procedures, such as platelet count, peripheral blood smear, and a platelet function screening test, will often lead the investigator to more specific analyses. Although platelet function testing is often limited to larger medical centers with highly trained technologists, newer technologies are being developed to simplify current procedures and make platelet function testing more accessible. This review provides an algorithm for platelet testing that may be of benefit to pathologists and physicians who deal with hemostatic disorders.
Introduction to Special Relativity

The goal of this lecture is to introduce the student to the theory of Special Relativity. Not to overload the content with mathematics, the author will stick to the simplest cases; in particular only reference frames using Cartesian coordinates and translating along the common x-axis as in Fig. 1 will be used. The general expressions will be quoted or may be found in the cited literature.
"Wish I Would Have Known that before I Started Using It": Contraceptive Messages and Information Seeking among Young Women.

In recent decades, women’s use of contraception has evolved. Women not only utilize contraceptives to prevent pregnancy, but also to manage menstruation and other factors related to their personal ...
Compressive second-harmonic generation imaging

We combine widefield second-harmonic generation imaging and phase-coded apertures with a Gerchberg-projected Wirtinger flow algorithm and regularized least-squares reconstruction for recovery of 3D volumes of collagen in a chicken tendon tissue.
Measurement and analysis of elastic and anelastic properties of alumina and silicon carbide

Measurements of dynamic Young's modulus, E, and damping as a function of temperature, T, were made for alumina and silicon carbide. The Young's modulus data were compared with some from the literature, and analysed in terms of a theoretical framework relating the Debye temperature, θD, with the elastic constants. For both materials this analysis yielded a ratio T0/θD which was near 0.4, where T0 is an empirical fitting constant for the plot of (E(0)−E)/T versus 1/T (E(0) is the value of E at 0 K). The analysis of the damping data in terms of an Arrhenius type dependence led to effective activation energies near kT, where k is Boltzmann's constant.
On Judging the Plausibility of Theories

It is a fact that if you arrange the cities (or, alternatively, the metropolitan districts) of the United States in the order of their population in 1940, the population of each city will be inversely proportional to its rank in the list (see Figure 1). The same fact is true of these cities at other census dates —back to the first census— and for the cities of a number of other countries of the world.
The NED IIS Project - Forest Ecosystem Management

For many years we have held to the notion that an Intelligent Information System (IIS) is composed of a unified knowledge base, database, and model base. The main idea behind this notion is the transparent processing of user queries. The system is responsible for “deciding” which information sources to access in order to fulfil a query regardless of whether this involves a data retrieval, an inference, a computational method, a problem solving module, or some combination of these. The NED IIS project is an effort to develop a robust, intelligent, goal-driven forest ecosystem management system to help forest managers plan and achieve wildlife, ecological, water, landscape, and timber goals. NED, using a blackboard architecture dominated by semi autonomous intelligent agents, integrates a core database, domain knowledge, meta-knowledge, and a GUI with external (possibly distributed) legacy and special purpose (heterogeneous) information sources. The current version of NED is NED-2. NED-2 is still under construction, however a prototype incorporating the major components of the architecture has been completed and demonstrated.
Liability of foreignness and membership in a regional economic group: Analysis of the European Union

Abstract This study examines the performance of foreign vs. domestic firms in a regional economic group. In particular, we focus on host country and foreign-owned firms in the European Union. Results provide evidence of a liability of foreignness—foreign-owned firms underperform host country firms. However, there is also evidence that liability of foreignness can vary across countries, and that foreign firms can overcome the liability of foreignness in some host countries, even industrialized ones. The results show the moderating effects of the host country and home country environments on the relative performance of foreign firms. Lastly, the results reveal that foreign-owned banks from highly competitive home countries underperform foreign firms from less competitive home countries.
A novel scheme to handle highly pulsed loads with a standard helium refrigerator

Helium refrigerator performance degrades rapidly when it has to handle a varying or pulsed heat load. A novel scheme is presented to handle highly pulsed 4.5 K cryogenic loads with a standard helium refrigerator by isolating it from these pulses. The scheme uses a relatively simple arrangement of control valves, heat exchangers, and a storage dewar. Applications include pulsed tokamak machines such as TPX (Tokamak Physics Experiment) and ITER (International Thermonuclear Experimental Reactor). For example, the TPX (currently in the conceptual design phase in a DoE contract) requires an average 4.5 K refrigerator capacity of about 10 kW; however, pulsed loads caused by eddy current and nuclear heating will exceed 100 kW. The scheme presented here provides a method for handling these pulsed loads. Because of the simple and proven nature of the components involved and the thermodynamic properties of the helium, the system could be implemented for projects such as TPX or ITER with little or no development.
THE CRITICAL ROLE OF SCHOOL PSYCHOLOGY IN THE SCHOOL MENTAL HEALTH MOVEMENT

School mental health (SMH) programs are gaining momentum and, when done well, are associated with improved academic and social–emotional outcomes. Professionals from several education and mental health disciplines have sound training and experiences needed to play a critical role in delivering quality SMH services. School psychologists, specifically, are in a key position to advance SMH programs and services. Studies have documented that school psychologists desire more prominent roles in the growth and improvement of SMH, and current practice models from national organizations encourage such enhanced involvement. This article identifies the roles of school psychologists across a three-tiered continuum of SMH practice and offers an analysis of current training and professional development opportunities aimed at such role enhancement. We provide a justification for the role of school psychologists in SMH, describe a framework for school psychologists in the SMH delivery system, discuss barriers to and enablers of this role for school psychologists, and conclude with recommendations for training and policy.
Research to Improve Cross-Language Retrieval - Position Paper for CLEF

Improvement in cross-language information retrieval results can come from a variety of sources - failure analysis, resource enrichment in terms of stemming and parallel and comparable corpora, use of pivot languages, as well as phonetic transliteration and Romanization. Application of these methodologies should contribute to a gradual increase in the ability of search software to cross the language barrier.
Analysis of matrix dynamics by atomic force microscopy.

Publisher Summary This chapter describes matrix dynamics by atomic force microscopy (AFM). Matrix research is about biological surfaces, so the AFM, which investigates surfaces, is a good instrument for matrix research. The AFM images surfaces at resolutions between sub-nanometer to several nanometers and also senses the material properties of surfaces, through phase imaging in tapping mode AFM. Analysis of matrix dynamics for atomic force microscopy can be divided into three broad categories. First, AFM imaging in fluid has revealed dynamic processes such as the movements of laminin arms and the real-time degradation of collagen. Second, molecular force spectroscopy, also in fluid, has revealed intramolecular forces in the matrix protein tenascin and intermolecular forces between integrin and fibronectin. Third, AFM in air, the most common use of AFM for matrix analysis, has revealed static interactions among matrix macromolecules such as the binding sites of laminin and of human blood factor IX on collagen IV, and of heparin on fibronectin.
Active Transport of d-Alanine and Related Amino Acids by Whole Cells of Bacillus subtilis

Whole cells of Bacillus subtilis transported d-alanine and l-alanine by two different systems. The high-affinity system (Km of 1 μM and Vmax of 0.6 to 0.8 nmol/min per mg of protein) was specific for the two stereoisomers of alanine. The low-affinity system (Km of 10 μM for l-alanine and 20 μM for d-alanine and glycine) had a Vmax of 5 to 12 nmol/min per mg of protein. This system transported glycine, d-cycloserine, and d-serine, in addition to d- and l-alanine. Azide inhibited the uptake of these amino acids and caused the efflux of d-alanine from preloaded cells. These data suggest that transport of these amino acids is energized by the electron transport chain.
Classification of Sleep Disorders

The American Academy of Sleep Medicine supported the work of committees of experts appointed in the sleep field for the development of the International Classification of Sleep Disorders, 2nd edn (ICSD-2). This 300-plus page book classifies and categorizes the spectrum of sleep disorders. This article provides the reader an abbreviated overview, focused on key parts of the ICSD-2, especially those that are new or changed information compared to the ICSD-1. These changes are highlighted and discussed. The rationale for the revisions is identified. This article also discusses the methodological changes, the benefits of the new version, and items that will assist the clinician or interested reader in the use of ICSD-2 for differential diagnosis among the types of sleep disorders.
Injection of Dilute Brine and Crude Oil/Brine/Rock Interactions

Sensitivity of oil recovery to injection brine composition has been reported for a variety of circumstances including trends of increased recovery of crude oil with decrease in salinity. Absolute permeabilities of sandstones to synthetic reservoir brines and dilutions of these brines show little sensitivity to salinity when the initial brine and injected brine are of the same composition. With reservoir brine as the initial brine and injection of dilute brine, the pH of the outflow brine increased and absolute permeability to brine decreased, but never to less than 50% of its original value. Such changes, if any, were much less for rocks with low clay content. During the course of recovery of crude oil, interfacial tensions of crude oil and dilute effluent brine were reduced by about 25% relative to values for crude oil and reservoir brine. Effluent brine pH increased after injection of low salinity brine, but showed no response in the absence of an initial water saturation. Changes in brine composition resulting from flow through Berea sandstone were small. Fines production and permeability reduction resulting from injection of dilute brine was greatly reduced by the presence of crude oil.
RepliCAD an automated approach to replacement part IC design

RepliCAD, Honeywell's replacement part design system, which provides a highly automated system for the verification of replacement part designs, is described. RepliCAD automates the tasks of SPICE simulation definition, execution, and analysis, and maximizes the available SPICE computing resources by automatically distributing the simulations across a network of SPICE servers on Apollo/Mentor workstations. It is concluded that RepliCAD has freed Honeywell's engineers from the tasks of managing, executing, and monitoring simulations and has allowed them to be more productive. >
How patients' self-disclosure about sickle cell pain episodes to significant others relates to living with sickle cell disease.

Objectives This cross-sectional study examines to whom and how fully sickle cell disease (SCD) patients talk to others about sickle cell pain, how helpful it is to talk with others about these pain episodes, and the association between talking to others about sickle cell pain episodes and patients' psychological adjustment and coping strategies in managing the disease. Methods A convenience sample of 73 African American patients with SCD (30 men and 43 women), were recruited from two SCD clinics at the time of routine medical visits. Most participants had been diagnosed with hemoglobin SS, and they reported an average number of 8.61 pain episodes in the previous 12 months. Participants were asked to whom, how fully, and how helpful it was to talk to significant others about SCD pain episodes experienced in the last 12 months. Patients also completed measures of their psychological adjustment as well as how they would manage a future sickle cell pain episode. Self-report ratings were made on Likert-type scales. Results Based on paired samples t-tests, participants talked significantly more fully about their thoughts and feelings concerning pain episodes to God and to their primary medical providers than to either their parents, siblings, or an intimate partner/close friend. Bivariate correlations indicated that amount and helpfulness of talking about pain episodes to God and to parents were significantly associated with better psychological adjustment on selected measures. Also, bivariate correlations indicated that helpfulness in talking with siblings, intimate partner/close friend, and primary medical providers was positively related with willingness to go to a physician in the event of a future pain episode. Conclusions The results document to whom and how helpful it is to talk with others about SCD pain episodes and how SCD disclosure is related to strategies for managing this disease.