cssi/SciSciGPT-SciSciNet huggingface dataset:
Coastal and Terrestrial Impact of the Isostatically Forced Late Quaternary Drainage Divide Shift, Penobscot and Kennebec Rivers, Maine, USA

KELLEY, A.R.; KELLEY, J.T.; BELKNAP, D.F., and GONTZ, A.M., 2011. Coastal and terrestrial impact of the isostatically forced Late Quarternary drainage divide shift, Penobscot and Kennebec Rivers, Maine, USA. Journal of Coastal Research, 27(6), 1085–1093. West Palm Beach (Florida), ISSN 0749-0208. Marine features associated with Late Quaternary isostatic adjustment are well documented in central and coastal Maine, United States. However, the effects of glacially induced land-surface tilting in the interior of the state and its affects on coastal landforms are not well understood. Investigations at Moosehead Lake, Maine’s largest lake, indicates that isostatically forced tilting shifted the lake’s outlet from the Penobscot River drainage to the Kennebec River drainage, resulting in a significant effect on marine delta formation through changes in the discharge and competence of the Kennebec and Penobscot Rivers, two of the largest in the region. Historic stream-gage data are used as an analogue to quantify the effect of the outlet shift on the relative discharge of these two rivers. These data suggest that, in the upper portions of the watersheds, the Penobscot River lost approximately 25% of its annual discharge, while the Kennebec River experienced an approximately 74% increase in annual discharge. The timing of this change, established in the abandoned lake outlet into the Penobscot River, coincides with the end of deposition of the Penobscot paleodelta in Penobscot Bay and the onset of deposition of the western lobe of the Kennebec paleodelta. This indicates that changing river discharges were also linked to changes in sediment loads at the rivers’ mouths. In addition, these findings imply that coarse-grained fluvial deposits (North Anson Formation) identified in the upper Kennebec valley may be the result of the rapid and large increase in river discharge associated with the divide shift. Recognition of both marine and fluvial features associated with isostatic adjustment emphasizes the importance of this process on early postglacial landscape formation. www.JCRonline.org
Wireless communication for smart grid applications at distribution level — Feasibility and requirements

Smart grid technology places greater demands for reliability on communications infrastructure. This work focuses on identifying requirements for distribution feeder level communications. Due to the large number of distribution components connected to the distribution level feeders, a massively deployed wireless communication network is identified as the potential technology for this application. This network would allow prioritized communication: high priority for abnormal events and system control operations, and low priority communication for asset management tasks. A three-layer wireless communication architecture is proposed in this work to increase the reliability and reduce the latency of event notification. Fault location is considered as an example application to illustrate the proposed architecture.
Distributed RC-filters with linearized MOS-transistors in CMOS technology

Two distributed RC filters (a low-pass and a bandpass) that use MOS transistors as distributed RC lines are presented. A scheme for compensating for nonlinearities in the MOSFET is used. Simulation results for a 2- mu m CMOS p-well process (MOSIS) are presented. High programmability is expected from two tuning points: the gain of the voltage amplifier to control the Q of the filters, and the DC bias of the MOSFETs to change omega /sub 0/. SPICE simulation results are presented. >
Citizenship acts and immigrant voting rights movements in the US

What happens to notions of national belonging in the US when non-citizen immigrants claim the right to vote at the local level for school boards and city councils? Is this a fundamental challenge to US citizenship norms, or an extension of the force of liberal discipline onto new citizen-subjects-in-formation? While academic literature has focused on historical, legal and normative ethical arguments about non-citizen voting, this article focuses on the vernaculars of citizenship discourses advocates and opponents invoke in order to win over local and state officials to their cause and how they both integrate and challenge official responses to their claims. Such attention to particularities is necessary to appreciate the ways in which citizenship practice is contingent on local political culture and history but also potentially transformative of larger institutions and discussions over national membership. Advocates put into practice arguments from the academic literature and borrowed through trans-local ...
Management of occult metastatic disease from salivary gland neoplasms.

• Evaluating salivary gland neoplasms is difficult because of the relatively low incidence of these lesions, their variable locations, and their multiple histologic cell types. Little has been reported on nodal metastases, whether manifest or occult, from these neoplasms. Ninety cases of salivary gland neoplasm are analyzed to provide a clearer understanding of the appropriate approach to occult salivary gland cervical metastases. Manifest regional metastases at the original presentation were absent in 72% (65/90). Few nodal metastases occurred after the primary tumor was controlled (2% [1/56]). Local recurrence (38% [34/90]) and distant metastases (25% [14/56]) were more common. Stage I and II disease was treated by surgical resection of the primary tumor alone; resection was combined with postoperative radiation therapy for stage III disease. Whenever the neck was entered for stage III disease, a conservative neck dissection was incorporated with the resection to reduce the postoperative irradiation field once the neck had been proved N, O histologically. Delayed nodal metastasis was treated by neck dissection alone. ( Arch Otolaryngol Head Neck Surg 1989;115:322-325)
Cytotoxic acridinylthiourea and its platinum conjugate produce enzyme-mediated DNA strand breaks

The reactions of plasmid DNA modified with the novel acridinylthiourea, 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea (1), and the corresponding intercalator-tethered platinum complex (2) with human type I and type II topoisomerases have been studied. Assays were based on evaluating DNA cleavage products resulting from incubations of drug-modified DNA in cell-free systems. 2 produces double-strand breaks in the presence of topo II while 1 proved to be a dual topo I/topo II poison.
Declarations of Dependence: The Long Reconstruction of Popular Politics in the South, 1861–1908 – By Gregory P. Downs

During the Civil War, and for several generations thereafter, North Carolina exhibited the power of dependency upon popular politics. In this work, Gregory P. Downs reviews the long political caree...
Using multiple measures to evaluate a dental faculty development program.

Introduction The formal preparation of dental professionals for teaching is increasingly seen as essential to enhance teacher effectiveness and student learning and to promote curricular initiatives. As a result, many dental schools have implemented a variety of faculty development programming. There is a body of literature that describes these programmes, but there is limited rigorous evaluation of them. The use of multiple measures of evaluation helps to compensate for potential inadequacies of individual methods. Analyses with multiple measures provide a more comprehensive view of whether a programme is achieving its learning outcomes. Materials and methods A dental faculty development programme, Class Advanced Clinical Teaching Scholars (ACTS), at New York University College of Dentistry (NYUCD) was evaluated with four different measures: pre- and post-programme tests of participants' level of relevant pedagogical knowledge, pre- and post-programme objective structured teaching examinations (OSTEs), pre- and post-programme self-assessments of teaching abilities and post-programme participant satisfaction surveys. Two of the measures used a comparison group of faculty. Results Results revealed that the Class ACTS participants significantly improved their knowledge; observed teaching performance in most teaching domains tested showed significant improvement; there was no significant change in self-assessed teaching abilities after participation; and the course was viewed positively by the participants. Conclusion Class ACTS, an advanced dental faculty development course, has been successfully implemented and evaluated with the use of multiple measures.
Evaluating The Importance Of Competencies Within Accounting Information Systems Curricula

In International Education Guideline No. 11, the International Federation of Accountants identified the essential information technology (IT) competencies, knowledge, and skills required for entry-level accounting positions. These IT competencies are classified into three categories: (1) IT concepts for business systems (nine competencies), (2) internal control in computer-based business systems (six competencies), and (3) the roles of the professional accountant in information systems (18 competencies classified into three subcategories). In this exploratory study, we surveyed accounting information systems educators about the relative importance of the IFAC competencies to prepare undergraduate students for entry-level accounting positions. The results provide accounting educators with an understanding of current practice regarding the relative emphasis placed on IT competencies in AIS courses. Using this information, the results may be used to guide the allocation of resources within the AIS curriculum.
Tunable RF-power-fading compensation of multiple-channel double-sideband SCM transmission using a nonlinearly chirped FBG

We demonstrate that a nonlinearly chirped fiber Bragg grating can compensate RF power degradation in subcarrier-multiplexed (SCM) systems that is caused by fiber dispersion. Our all-optical technique provides tunable dispersion that compensates for multiple SCM channels simultaneously. We achieve RF-power-fading compensation for two SCM/BPSK 156-Mb/s channels in which the fading is reduced from 15 and 6 dB, respectively, to <0.5 dB for each channel.
Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Abnormal Placentation and Fetal Growth

Assisted reproductive technologies (ART) have been associated with several adverse perinatal outcomes involving placentation and fetal growth. It is critical to examine each intervention individually in order to assess its relationship to the described adverse perinatal outcomes. One intervention ubiquitously used in ART is superovulation with gonadotropins. Superovulation results in significant changes in the hormonal milieu, which persist during the peri-implantation and early placentation periods. Epidemiologic evidence suggests that the treatment-induced peri-implantation maternal environment plays a critical role in perinatal outcomes. In this study, using the mouse model, we have isolated the exposure to the peri-implantation period, and we examine the effect of superovulation on placentation and fetal growth. We report that the nonphysiologic peri-implantation maternal hormonal environment resulting from gonadotropin stimulation appears to have a direct effect on fetal growth, trophoblast differentiation, and gene expression. This appears to be mediated, at least in part, through trophoblast expansion and invasion. Although the specific molecular and cellular mechanism(s) leading to these observations remain to be elucidated, identifying this modifiable risk factor will not only allow us to improve perinatal outcomes with ART, but help us understand the pathophysiology contributing to these outcomes.
El secoya del Putumayo: aportes fonológicos para la reconstrucción del Proto-Tucano Occidental

El presente estudio tiene dos propositos fundamentales: (i) ofrecer la primera descripcion fonologica de la lengua secoya (Tucano Occidental) hablada en comunidades ubicadas en los afluentes del rio Putumayo, Peru; y, (ii) contribuir al avance de estudios comparativos de la rama occidental de la familia tucano. Actualmente existen algunos estudios de la variedad secoya hablada en el rio Aguarico, Ecuador, pero no existe ninguno de la variedad hablada en el Putumayo. Tambien hay avances significativos en la descripcion de las lenguas tucano de la rama oriental, pero los vacios en nuestro conocimiento de la rama occidental son todavia importantes. Este estudio pretende cubrir algunos de esos vacios. Algunos rasgos fonologicos relevantes del secoya del Putumayo incluyen la presencia de un segmento glotal en posicion de coda alli donde otras lenguas de la familia poseen nucleos vocalicos con tono bajo; es decir, en esta variedad no existe tono contrastivo. Otro rasgo importante es la insercion de consonantes nasales en posicion de coda alli donde la nasalizacion progresiva encuentra una consonante que la bloquea; asi, en esta variedad el alcance de la nasalizacion es relativamente transparente. El secoya del Putumayo, difiere en aspectos importantes del secoya del Aguarico. Por ejemplo, mientras en la variedad del Putumayo existen procesos de lenicion a partir de los fonemas africados /ʦ, ʤ/, en la variedad del Aguarico los fonemas correspondientes serian /s, z, y/. Asimismo, en la variedad del Putumayo no existen glotales en posicion de ataque, tampoco procesos de aspiracion de consonantes oclusivas, ambos rasgos asociados con el secoya del Aguarico.
Several Problems for Predicate Decompositions

In (1a) the patient the pie is realized as an object and in (1b) it is realized as an oblique marked by the preposition at. There is a semantic effect associated with this alternation: when the pie is a direct object it is known to have necessarily been affected in some way, but when it is an oblique it may or may not have been affected, depending on the context (i.e. it is underspecified for affectedness). We point out three general properties of such alternations, which a theory of argument realization should ideally capture. These are given in (2)–(4).
Survival, Growth, and Reproduction of the Fall Armyworm (Lepidoptera: Noctuidae) as Affected by Resistant Corn Genotypes

A comparative study of the fall armyworm, Spodoptera frugiperda (J. E. Smith), reared on leaf-feeding resistant and susceptible corn genotypes was conducted in the field and laboratory in 1983 to determine the effects of resistance on survival, growth, and reproduction of this insect. Larvae reared on resistant genotypes had higher mortality and surviving larvae were significantly smaller at day 7 in both field and laboratory tests than were larvae reared on susceptible genotypes. Significantly longer larval developmental times were required for larvae fed on resistant as opposed to susceptible leaf tissues. Female pupae from larvae reared on resistant leaf tissue weighed 11.4% less than those reared on susceptible leaf tissue. No significant differences among corn genotypes were detected for male pupal weights, duration of pupae development, percent adult emergence and deformity, or female longevity and fecundity. Under laboratory conditions, net reproductive rates of fall armyworm cohorts reared on resistant genotypes were 34–50% less than for those reared on susceptible genotypes, indicating that population size of the following generation would be greatly reduced.
Fetal cerebral blood flow and metabolism during oligemia and early postoligemic reperfusion.

The early time period following ischemia may be of pathogenetic importance in hypoxic-ischemic brain injury. Global cerebral oligemia was induced in ten late gestation fetal sheep by inflation of a balloon occluder around the brachiocephalic artery. Cerebral blood flow, oxygen, glucose, and lactate net flux, and oxygen delivery were measured by the Fick principle following 1 h of oligemia and at 5, 30, and 60 min of postoligemic reperfusion. During oligemia, cerebral blood flow decreased by 74 ± 10% (mean ± SD) and oxygen consumption decreased by 34 ± 24%. The glucose:oxygen quotient was elevated throughout the oligemic period. In the early (5 min) reperfusion period, blood flow and oxygen delivery were not different from control but oxygen consumption was persistently depressed by 27 ± 32%; fractional extraction of oxygen was 0.38 ± 0.10 during control and 0.24 ± 0.09 during early reperfusion. The venous oxygen tension increased modestly from 15.2 ± 2.4 to 18.0 ± 1.7 mm Hg; the postoligemic venous pO2 wa...
Gender and class violence in the intimate city

Ayona Datta’s essay is thought-provoking and evocative and I am grateful to be part of this conversation. She argues that “material interventions” are not the solutions for sexual violence and that...
Foreign capital in Korea’s economic development, 1960–1985

The relationship between foreign capital and state autonomy is investigated in the rapidly developing South Korean economy. The changing composition and the sectoral distribution of the different types of foreign capital, the role of the Korean state in the acquisition and distribution of foreign capital, and the implications of foreign capital on the autonomy and capacity of the state are studied. The findings show that public loans and state-guaranteed commercial loans in the 1960s and 1970s have supported and strengthened state autonomy, while direct foreign investment (DFI) and commercial loans in the 1980s could potentially undermine it. Significant changes in the 1980s—rapid increase of Japanese DFI in hotels, commerical loans behaving more like DFI, and changing industrial orientation of the Korean economy toward more high-technology sectors—suggest that the types of foreign capital which are more independent of state control and more keen on market signals will increase in the future. This has importnat implications for future Korean economic development.
Experimental research on Cr~(4+):YAG passively Q-switched solid state laser based on thermal bonding

In order to obtain integrative ns-pulsed solid-state laser,a Cr4+∶YAG passively Q-switched laser was designed,which combined Cr4+∶YAG with Nd∶YAG by the aid of thermal bonding,and whose F-P laser cavity was composed by coating films on its both sides.The quasi-continuous laser pulse output was realized in the experiment by directly pumping the crystal from its end by the fiber coupled laser diode.The pulse width(5.3ns) was obtained by the p6703A photo-detector.A radiator was designed to eliminate the thermal lens effect existing in the experiment.The contrast of the air blowing and the radiator was implemented.The experiments approves that the design is feasible and the laser works well.
Spatial Perception is Continuously Constrained by Goals and Memories.

Perceptual variables such as perceived distance contain information about future actions. Often our goals involve the integration of another’s goals, such as lifting heavy objects together. The purpose of this study was to investigate how another’s actions might influence one’s own goal-oriented perceptions, specifically, verbal distance estimates. Using a within-subject paradigm, we replicated a well-known finding that carrying a weighted backpack results in larger distance estimates relative to not carrying a backpack. In a crucial second condition, this effect was reversed: distance estimates were significantly greater when not carrying a weighted backpack than when carrying a backpack. In this condition, participants provided distance estimates while wearing a weighted backpack during the first phase and then gave estimates while not wearing a backpack, but following an experimenter wearing a weighted backpack in the second phase. Three additional conditions systematically documented how the observations of another’s actions influenced distance estimates.
ImmunoPET for assessing the differential uptake of a CD146-specific monoclonal antibody in lung cancer

Purpose Overexpression of CD146 in solid tumors has been linked to disease progression, invasion, and metastasis. We describe the generation of a 64Cu-labeled CD146-specific antibody and its use for quantitative immunoPET imaging of CD146 expression in six lung cancer models.
Considering about the Hearing Impairment of the Invisible Disability from My Experience in Surabaya

I am working for the visitors of otolaryngology special hospital “Kamio Memorial Hospital” as a nurse. Having begun to work here I immediately felt the difficulty of how to communicate with the patients eight years ago.
Sovereign Wealth and the Extraterritorial Manipulation of Corporate Conduct: A Multifaceted Paradigm in Transnational Law

Global legal harmonization is an aspect of transnational law whereby a family of norms is formed by a non-state legal order. Sovereign wealth funds, a diverse group in terms of their countries of origin, size, investment strategies, asset allocation tactics, and their underlying purposes, are contributing to the harmonization by setting and enforcing cross-border ethical norms and governance standards and by quickly becoming major participants in the community of merchants through their investment activities. This paper examines the various aspects of — and the implications for — SWFs as transnational law makers, a significant phenomenon for the global family of standards and a potential challenge for the more formalistic state-based legal orders. The chapter examines the SWF adoption of general legal principles and customs as advanced by a global civil society as well as through standardized contract forms and conduct codes. The chapter also analyzes the SWFs’ voluntary enactment of informal soft laws and the creation of norm setting institutions. The chapter concludes that SWFs are indeed a part of a diffused yet multilevel and coordinated political system that defies the state-centric paradigms, contributing to the dynamism that defines transnational law but also creating concerns related to legitimacy, democratic authority and democratic deficit.
Robust, wide range hydrogen sensor

A new robust, wide-range hydrogen sensor technology integrates catalytic gate transistors and resistors with a baseline CMOS process. Pd or PdNi gate transistors detect low concentrations of hydrogen (ppm) and Pd or PdNi thin film resistors sense higher concentrations of hydrogen (up to 100%). Fabrication of both sensors on the same die allows detection of hydrogen over a dynamic range of 6 orders of magnitude. On-chip power transistor heaters and diode thermometers allow accurate chip temperature control. >
Seasonal Effect on Ocular Sun Exposure and Conjunctival UV Autofluorescence.

PURPOSE To evaluate feasibility and repeatability of measures for ocular sun exposure and conjunctival ultraviolet autofluorescence (UVAF), and to test for relationships between the outcomes. METHODS Fifty volunteers were seen for two visits 14 ± 2 days apart. Ocular sun exposure was estimated over a 2-week time period using questionnaires that quantified time outdoors and ocular protection habits. Conjunctival UVAF was imaged using a Nikon D7000 camera system equipped with appropriate flash and filter system; image analysis was done using ImageJ software. Repeatability estimates were made using Bland-Altman plots with mean differences and 95% limits of agreement calculated. Non-normally distributed data was transformed by either log10 or square root methods. Linear regression was conducted to evaluate relationships between measures. RESULTS Mean (±SD) values for ocular sun exposure and conjunctival UVAF were 8.86 (±11.97) hours and 9.15 (±9.47) mm, respectively. Repeatability was found to be acceptable for both ocular sun exposure and conjunctival UVAF. Univariate linear regression showed outdoor occupation to be a predictor of higher ocular sun exposure; outdoor occupation and winter season of collection both predicted higher total UVAF. Furthermore, increased portion of day spent outdoors while working was associated with increased total conjunctival UVAF. CONCLUSIONS We demonstrate feasibility and repeatability of estimating ocular sun exposure using a previously unreported method and for conjunctival UVAF in a group of subjects residing in Ohio. Seasonal temperature variation may have influenced time outdoors and ultimately calculation of ocular sun exposure. As winter season of collection and outdoor occupation both predicted higher total UVAF, our data suggests that ocular sun exposure is associated with conjunctival UVAF and, possibly, that UVAF remains for at least several months after sun exposure.
Does social presence relate to knowledge sharing in virtual learning teams

The purpose of this study was to identify whether social presence relates to knowledge sharing in virtual learning teams in distance education. The participants in the study were 1355 students engaged in distance education programs. Both split sample and the total sample were used for different analyses. The findings of the study confirmed social presence as a two-dimensional construct, which involves interactive responses and cohesive-affective responses. Only interactive responses were found to relate to knowledge sharing. The results of the study can be used by instructional designers and instructors to design instructional environments that encourage effective social interaction towards knowledge sharing. https://doi.org/10.34105/j.kmel.2016.08.039
Classical simulation of quantum circuits by dynamical localization: Analytic results for Pauli-observable scrambling in time-dependent disorder

We extend the concept of Anderson localization, the confinement of quantum information in a spatially irregular potential, to quantum circuits. Considering matchgate circuits, generated by time-dependent spin-$\frac{1}{2}$ $XY$ Hamiltonians, we give an analytic formula for the out-of-time-ordered correlator of a local observable and show that it can be efficiently evaluated by a classical computer even when the explicit Heisenberg time evolution cannot. Because this quantity bounds the average error incurred by truncating the evolution to a spatially limited region, we demonstrate dynamical localization as a means for classically simulating quantum computation and give examples of localized phases under certain spatiotemporal disordered Hamiltonians.
An Accounting Information Systems Perspective on Data Analytics and Big Data

ABSTRACT Forty-six academics and practitioners participated in the second Journal of Information Systems Conference to discuss data analytics and Big Data from an accounting information systems perspective. The panels discussed the evolving role of technology in accounting, privacy within the domain of Big Data, and people and Big Data. Throughout all three panels, several topics emerged that impact all areas of accounting—developing enhanced analytical and data handling skills; evaluating privacy, security requirements, and risks; thinking creatively; and assessing the threat of automation to the accounting profession. Other topics were specific to a segment of the profession, such as the growing demand for privacy compliance audits and the curriculum adjustments necessary to develop data analytic skills. This commentary synthesizes and expands the discussions of the conference panels and suggests potential areas for future research.
Delay in Diagnosis of Celiac Disease in Patients Without Gastrointestinal Complaints.

Abstract Purpose The purpose of our study is to investigate the delay in diagnosis of patients with biopsy-proven celiac disease in those who present with gastrointestinal complaints vs nongastrointestinal complaints at our tertiary care center. Celiac disease is an autoimmune disorder that affects approximately 1% of the population worldwide. Celiac disease can have variable clinical presentations; it can be characterized by predominately gastrointestinal symptoms, or it may present without any gastrointestinal symptoms. Methods We retrospectively reviewed the charts of 687 adult patients who carried the diagnosis of celiac disease. Patients included had biopsy-proven celiac disease and were categorized based on presence or absence of gastrointestinal symptoms prior to their diagnosis. Results There were 101 patients with biopsy-proven celiac disease that met inclusion criteria. Fifty-two patients presented with gastrointestinal symptoms and 49 had nongastrointestinal complaints. Results from Mann-Whitney statistical analysis showed a median delay in diagnosis of 2.3 months for the gastrointestinal symptoms group and 42 months for the nongastrointestinal group ( P P = .004). Of patients with nongastrointestinal symptoms, 69.4% had anemia, compared with 11.5% of the gastrointestinal symptom group ( P P = .997). Conclusions Although there is growing awareness of celiac disease, the delay in diagnosis for patients without gastrointestinal symptoms remains prolonged, with an average delay of 3.5 years.
Implementing temporal integrity constraints using an active DBMS

The system presented in this paper allows automatic and efficient translation of integrity constraints formulated in past temporal logic into rules of the Starburst DBMS. During the compilation, the set of constraints is checked for the safe evaluation property. The result of the compilation is a set of Starburst SQL statements that define all the necessary rules needed for enforcing the given constraints. There is no need for an additional run-time constraint monitor. When the rules are activated, all updates to the database that violate any of the constraints are automatically rejected (i.e. the corresponding transaction is aborted). In addition to efficient implementation, this approach offers a clean separation of application programs and the integrity checking code. >
Benchmarking vulnerability scanners: An experiment on SCADA devices and scientific instruments

Cybersecurity is a critical concern in society today. One common avenue of attack for malicious hackers is exploiting vulnerable websites. It is estimated that there are over one million websites that are attacked daily. Two emerging targets of such attacks are Supervisory Control and Data Acquisition (SCADA) devices and scientific instruments. Vulnerability assessment tools can help provide owners of these devices with the knowledge on how to protect their infrastructure. However, owners face difficulties in identifying which tools are ideal for their assessments. This research aims to benchmark two state-of-the-art vulnerability assessment tools, Nessus and Burp Suite, in the context of SCADA devices and scientific instruments. We specifically focus on identifying the accuracy, scalability, and vulnerability results of the scans. Results of our study indicate that both tools together can provide a comprehensive assessment of the vulnerabilities in SCADA devices and scientific instruments.
Synthesis and Evaluation of Sterically Demanding Ruthenium Dithiolate Catalysts for Stereoretentive Olefin Metathesis

Dithiolate ligands have recently been used in ruthenium-catalyzed olefin metathesis and have provided access to a kinetically E selective pathway through stereoretentive olefin metathesis. The typical dithiolate used is relatively simple with low steric demands imparted on the catalyst. We have developed a synthetic route that allows access to sterically demanding dithiolate ligands. The catalysts generated provided a pathway to study the intricate structure–activity relationships in olefin metathesis. It was found that DFT calculations can predict the ligand arrangement around the ruthenium center with remarkable accuracy. These dithiolate catalysts proved resistant to ligand isomerization and were stable even under forcing conditions. Additionally, catalyst initiation and olefin metathesis studies delivered a better understanding to the interplay between dithiolate ligand structure and catalyst activity and selectivity.
Imaging studies in pediatric fibromuscular dysplasia (FMD): a single-center experience.

Fibromuscular dysplasia (FMD) is a non-inflammatory vascular disease that in children unlike in adults shows no sex predilection. FMD is often underdiagnosed, and its pathophysiology is unclear. Delayed diagnosis may lead to refractory hypertension and decreases the chance of successful treatment. Doppler ultrasound (US), magnetic resonance angiography (MRA), computed tomography angiography (CTA), and catheter-based angiography (angiography) are currently used to help make a clinicoradiological diagnosis of FMD. The main aim of the study was to compare the efficacy of imaging modalities which can allow for earlier and improved detection. Furthermore, an anatomical mapping of the location of lesions can help determine the best treatment modalities. All patients with non-syndromic non-inflammatory renovascular hypertension were recruited from the Nephrology Department at the Children’s Hospital of Philadelphia (CHOP) and enrolled in the U.S. FMD Registry maintained at the University of Michigan. Clinical presentation and imaging findings on US, CT, and MRI of children diagnosed with FMD were evaluated. Mean age at diagnosis was 7 ± 4.9 years (4 months–17 years). Family history of hypertension (HTN) (52%), FMD (8.7%), Caucasian (60%), headache (48%), and HTN (80%) were the most prevalent symptom and sign at presentation. Bruits were 100% specific for renal artery stenosis (RAS) diagnosis but were heard in the minority of patients (3 patients, 12%). FMD was mainly unifocal within a single site (68%) or multiple sites (28%) and involved the main or first order renal branch in about 68% of children. Isolated distal lesions beyond the second order branches were found in about 25% of children. US imaging was significantly less sensitive than angiography (28%, p = 0.003). MRA had a better sensitivity (62.5%, p = 0.3) than US. Overall, CTA had the best sensitivity (84.2%, p = 0.4) compared to angiography; however, only angiography showed distal vessel disease. Limitations of the study include the sample size and biases—only patients diagnosed with FMD were included in this study and most patients were referred to a pediatric nephrologist for unexplained hypertension. Angiography should be performed as part of the initial work-up of any child suspected of having renovascular FMD, regardless of the findings seen on US, MRA, or CTA.
Radionuclidic purity assessment of Yttrium-90 (Y-90) microspheres

2206 Objectives: Yttrium-90 (Y-90) glass and resin microspheres are being used as radioembolization agents for the treatment of liver metastases. Microspheres are delivered via the hepatic artery using FDA approved delivery devices. Although Y-90 residual activity remaining in the single use components of the treatment device is decayed for at least 60 days, radiation levels still exceed background radiation levels. The purpose of this study was to identify the radionuclidic impurity remaining in the treatment device after delivery of Y-90 microspheres. Methods: To determine if there is a relationship between the number of microspheres and the radioimpurity, analysis was preformed on plastic containers containing the spent single use components of the Y-90 microsphere delivery device as well as unused Y-90 microsphere dose vials. The gamma energy spectrum analysis of the decayed Y-90 microsphere samples was obtained using a Biodex Atomlab 950 with a 5 cm x 5 cm NaI(Tl) detector. Samples were placed 17 cm from the detector surface. Photopeak energies from 0 keV to 1500 keV were acquired. Radionuclide identification was demonstrated by photopeaks, assumptions from microsphere production, and decay of the samples. Results: Following assessment of radionuclidic purity of the decayed Y-90 microsphere samples, potential radioimpurities include: Y-88, Eu-152, Eu-154, Co-60, Co-58, Co-57, Co-56, and Fe-59. Spectrum peaks were observed at approximately 123, 344, 500, and 900 keV. Spectra analysis demonstrates that Yttrium-88 (Y-88) and Europium-152 (Eu-152) were present in both resin and glass microspheres. Conclusions: These findings suggest that the primary radionuclidic impurity identified in the single use components of the treatment device after infusion of Y-90 microspheres for samples decayed up to six months was Y-88. For samples decayed greater than six months, the primary radionuclidic impurity was Eu-152. Yttrium-88 has a half-life of 106.65 days. Europium-152 has a half life of 13.54 years. Significant activity, indicating a long-lived impurity found in the residual delivery device, may have to be shipped to a radioactive waste disposal facility.
Cardiac resynchronization therapy pacemakers versus defibrillators in older non-ischemic cardiomyopathy patients.

Abstract Introduction With the recent publication of the negative DANISH trial, the mortality benefit of the implantable cardioverter-defibrillator (ICD) has been put in question in patients with non-ischemic cardiomyopathy (NICM). Because a majority of patients in DANISH receive cardiac resynchronization therapy (CRT) devices, we investigated in the present study the survival of recipients of CRT pacemakers (CRT-P) versus CRT ICDs (CRT-D) in a cohort of older (≥75 years) NICM patients at our institution. Methods A total of 135 NICM patients with CRT device were identified (42 with CRT-P and 93 with CRT-D) and were followed to the endpoint of all-cause mortality. Overall survival was compared between the CRT-P and CRT-D groups with adjustment for differences in baseline characteristics. Results Over a median follow-up of 46 months from the time of CRT device implantation, there were 54 total deaths (40%): 14 in the CRT-P (33%) and 40 in the CRT-D (43%) groups. Overall, CRT-P recipients had similar unadjusted mortality compared to CRT-D recipients (hazard ratio [HR] 1.04, 95% confidence interval [CI] 0.56–1.93), and this remained unchanged after adjusting for unbalanced covariates (HR 0.95, 95% CI 0.47–1.89) including left ventricular ejection fraction, used of angiotensin converting enzyme inhibitors/angiotensin receptor blockers, and the Charlson comorbidity index. Conclusion Our data support that in older NICM patients with CRT devices, the addition of ICD therapy does not improve survival.
Not Just Black and Not Just a Woman: Black Women Belonging in Computing

A sense of belonging is key to pursuing and persisting in computing. It is also one of the reasons for the low representation of women and Black people in computing. Research has attempted to understand why these underrepresented groups feel like they do not belong in computing. These initiatives tend to analyze race and gender separately as if people experience these aspects of identity separately. For Black women who are seeking to belong in computing, these sorts of analyses are problematic. Black women are not just “women plus color, or Black plus gender” [1]. Intersections of their race and gender yield unique experiences for them. Thus, analyses that only focus on women’s experiences or Blacks’ experiences leaves out the many nuances that result from one being both a woman and Black. This paper is an exploration of “what it means to belong” in computing. By analyzing Black womens multiple identities through an intersectional lens, we show that most research for Black people or women is not inclusive of Black womens unique perspectives. We make visible a gap in computing education research that does not address intersectionality.
Solar PV Power Plant Underground Cable Sizing Case Study

A cable ampacity study for a PV power plant is evaluated based on temperature measurements taken during normal operation for one year. Differences between the design and the installation are discussed regarding their impact on cable temperature. Soil thermal resistivity measurements are reviewed, highlighting the need for the design engineer to properly specify the soil conditions for the measurement. The measured temperature was significantly less than the temperature calculated using the Neher-McGrath method.
On the Possibility of Discrimination of Mixed Mode Fatigue Fracture Mechanisms in Adhesive Composite Joints by Advanced Acoustic Emission Analysis

Acoustic emission (AE) from pure and mixed mode fatigue fracture of adhesive composite joints was recorded and analyzed. Transient AE signal classification was attempted by a computational pattern recognition analysis. Good separation was achieved for pure mode AE signals from the double cantilever beam (mode I) and end notch fracture (mode II) tests. AE signals from the mixed mode lap joint test were found to be closer to the mode II fracture signals. The results may provide insight into the fracture mechanisms in joints and can be used for the development of mechanism-based predictive models of fracture and life.
Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses

Previous genetic studies on susceptibility to otitis media and airway infections have focused on immune pathways acting within the local mucosal epithelium, and outside of allergic rhinitis and asthma, limited studies exist on the overlaps at the gene, pathway or network level between the upper and lower airways. In this report, we compared [1] pathways identified from network analysis using genes derived from published genome-wide family-based and association studies for otitis media, sinusitis, and lung phenotypes, to [2] pathways identified using differentially expressed genes from RNA-sequence data from lower airway, sinus, and middle ear tissues, in particular cholesteatoma tissue compared to middle ear mucosa. For otitis media, a large number of genes (n = 1,806) were identified as differentially expressed between cholesteatoma and middle ear mucosa, which in turn led to the identification of 68 pathways that are enriched in cholesteatoma. Two differentially expressed genes CR1 and SAA1 overlap in middle ear, sinus, and lower airway samples and are potentially novel genes for otitis media susceptibility. In addition, 56 genes were differentially expressed in both tissues from the middle ear and either sinus or lower airways. Pathways that are common in upper and lower airway diseases, whether from published DNA studies or from our RNA-sequencing analyses, include chromatin organization/remodeling, endocytosis, immune system process, protein folding, and viral process. Taken together, our findings from genetic susceptibility and differential tissue expression studies support the hypothesis that the unified airway theory wherein the upper and lower respiratory tracts act as an integrated unit also applies to infectious and nonallergic airway epithelial disease. Our results may be used as reference for identification of genes or pathways that are relevant to upper and lower airways, whether common across sites, or unique to each disease.
Mindfulness as one component of an integrative approach to migraine treatment in clinical practice: companion editorial.

In this month’s publication of ‘Mindfulness in Migraine: A Narrative Review’ we described the evidence to date of mindfulness-based interventions (MBIs) for the treatment of migraine [1]. Of the ei...
Real-time oxygenation mapping from structured light imaging with deep learning

Tissue oxygenation (StO2), which is the fraction of oxygenated hemoglobin in biological tissues, is an important biomarker that can reveal information about tissue viability and underlying pathologies. The continuous monitoring of StO2 is also useful for surgical guidance and patient management. In recent years, Spatial Frequency Domain Imaging (SFDI) has emerged as an elegant solution for mapping wide-field StO2. However, conventional SFDI requires capturing a sequence of images at different spatial frequencies and wavelengths, resulting in slow acquisition times and challenges with moving objects. Model-based single-snapshot techniques have shortened the acquisition time but introduce image artifacts and decrease accuracy. Here we propose a deep-learning technique for real-time StO2 mapping from snapshot structured light images. We train content-aware generative adversarial networks (OxyGAN) on pairs of structured light input at 659nm and 851nm wavelengths and StO2 ground truth predicted by conventional SFDI. We demonstrate that OxyGAN is not only capable of rapid data acquisition and processing but is also more accurate than a model-based benchmark. We also compare OxyGAN to a hybrid model that uses separate networks to estimate optical absorption at two wavelengths followed by Beer-Lambert fitting. The end-to-end OxyGAN approach shows better performance in terms of both speed and accuracy. We additionally demonstrate real-time OxyGAN by applying it to videos of in vivo tissues. OxyGAN has the potential to enable wide-field, real-time, and accurate tissue oxygenation measurements in many clinical applications.
Optically Controlled Supercapacitors with Semiconductor Embedded Active Carbon Electrodes

Supercapacitors, S-C - capacitors that take advantage of the large capacitance at the interface between an electrode and an electrolyte - have found many short-term energy applications. We concentrate here on optically induced, electrical and thermal effects. The parallel plate cells were made of two transparent electrodes (ITO), each covered with semiconductor-embedded, active carbon (A-C) layer. While A-C appears black, it is not an ideal blackbody absorber that absorbs all spectral light indiscriminately. In addition to relatively flat optical absorption background, A-C exhibits two distinct absorption bands: in the near-IR and in the blue. The first may be attributed to absorption by OH- group and the latter, by scattering, possibly by surface plasmons. Here, optical and thermal effects of sub-micron size SiC particles that are embedded in A-C electrode, are presented. Similarly to nano-Si particles, SiC exhibits blue band absorption, but it is less likely to oxidize. Using Charge-Discharge (CD) experiments, the relative optically related capacitance increase may be as large as ~34% (68% when the illuminated area is taken into account). Capacitance increase was noted as the illuminated samples became hotter. This thermal effect amounts to 20% of the overall relative change using CD experiments. The thermal effect was quite large when the SiC particles were replaced by CdSe/ZnS quatum dots; for the latter, the thermal effect was 35% compared with 10% for the optical effect. When analyzing the optical effect one may consider two processes: ionization of the semiconductor particles and charge displacement under the cell's terminals - a dipole effect. Our model suggests that the capacitance increase is related to an optically induced dipole.
Episodic, severe abdominal pain due to isolated jejunal Crohn’s disease

Small bowel Crohn's disease can present with episodic, relapsing, and remitting symptoms and delays in the diagnosis are common. We present a case of a young woman with three years of intermittent abdominal pain and nausea with negative previous evaluations. On presentation, inflammatory markers were elevated, and repeat imaging showed jejunal inflammation, with histopathological examination showing non-caseating granulomas of the small bowel consistent with Crohn's disease. This case highlights the importance of gastroenterologist recognizing the alarm signs in a patient with unexplained symptoms and adds to the literature on the clinical presentation of a rare diagnosis of isolated jejunal Crohn's disease.