cssi/SciSciGPT-SciSciNet huggingface dataset:
Depot naltrexone: antagonism of the reinforcing, subjective, and physiological effects of heroin.

Naltrexone is an opioid antagonist that is currently approved as a treatment for opioid and alcohol dependence. Although it is highly effective in completely antagonizing the effects of opioids, medication noncompliance is a difficult obstacle to treatment. Therefore, a sustained-release form of naltrexone may improve treatment outcome. The present study was designed to evaluate the time course, safety, and effectiveness of a depot formulation of naltrexone (Depotrex®). Five heroin-dependent individuals participated in an 8-week inpatient study. After a 1-week detoxification period, the effects of a range of heroin doses (0, 6.25, 12.5, and 25 mg, i.v.) were examined. Participants then received 384 mg naltrexone base. The effects of heroin were again evaluated for the next 6 weeks. One dose of heroin was tested per day and the entire dose range was tested each week. Doses were administered in non-systematic order. During a morning sample session, participants received a dose of heroin and $20 and subjective, performance, and physiological effects were measured both before and after drug administration. During an afternoon choice session, participants were given the opportunity to choose the sampled heroin dose and/or amount of money using a modified progressive ratio procedure. Depot naltrexone antagonized both the reinforcing and subjective effects of heroin for 4–5 weeks. Subjective ratings of withdrawal were reduced after week 2 and throughout the remainder of the study. The effects of heroin on mean trough pupil diameter began to emerge by week 5. There were no clinically significant effects on respiratory or cardiovascular function. The present results extend our previous findings by showing that the reinforcing effects of heroin were reduced for 4–5 weeks after administration of 384 mg depot naltrexone.
Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation

BACKGROUND Genome-wide association studies (GWAS) have led to the discovery of multiple SNPs that are associated with prostate cancer (PCa) risk. These SNPs may potentially be used for risk prediction. To date, there is not a stable estimate of their effect on PCa risk and their contribution to the genetic variation both of which are important for future risk prediction.
Bands from Doubly Excited Levels of the Hydrogen Molecule

A band system of ${\mathrm{H}}_{2}$ is described which has as upper state ${(2p\ensuremath{\sigma})}^{2}^{1}\ensuremath{\Sigma}$. Although this state has two electrons excited, its energy is about the same as that of the states with only one electron excited to a two-quantum state. The position of the lines and their intensities are very irregular. These irregularities, however, can be satisfactorily explained as being due to the interaction with the $(1s\ensuremath{\sigma})(2s\ensuremath{\sigma})^{1}\ensuremath{\Sigma}$ state.
Kristin's Journey Through Breast Cancer: A Social Constructionist Perspective

Marriage and family therapists are often not prepared for clients entering therapy with chronic illness. This article chronicles an individual's journey through the psychological experience and survival of breast cancer. It also addresses some of the issues and problems persons with breast cancer may experience, taking their spouses and families into consideration. Throughout this paper a distinction is made between the illness experience, the illness behavior and the illness meaning. This is accomplished against a social psychological backdrop of the definitions given to the illness and the resultant scripts taken on by the individual, the couple and family members. A visualization component to a four stage therapeutic model based on social constructionist assumptions is then presented. The model is illustrated by the case material throughout.
Active impedance matching, calibration, and interference mitigation for the BYU/NRAO L-band phased array feed

This paper is a summary of recent research progress towards scientifically useful low noise, high sensitivity phased array feeds for radio telescopes. Developments include techniques for designing phased array antennas to realize an active impedance matching condition that minimizes receiver noise over the array field of view, array beamforming algorithms that allow a controlled tradeoff between side-lobe control and peak beam sensitivity, and spatial filtering algorithms that achieve unprecedented levels of interference suppression for moving sources of unwanted radio signals.
Dynamic expansion of the coronary arteries: Implications for intravascular ultrasound measurements

The majority of coronary artery blood flow occurs in diastole; however, systolic epicardial coronary artery expansion has been described. With the advent of intravascular ultrasound, precise measurements of arterial structures with excellent spacial and temporal resolution are now readily available. However, the effect of dynamic expansion of the coronary arteries on routine intravascular ultrasound measurements has not been assessed. The purpose of this study was to determine in vivo the presence, timing, and extent of dynamic changes in the coronary arteries and saphenous vein grafts and to assess their implications for intravascular ultrasound measurements. Intravascular ultrasound images were obtained with simultaneous electrocardiographic monitoring in 202 coronary artery and 50 saphenous vein graft sites in 32 patients with varying plaque burden and morphologic features. Arterial, luminal, and plaque area were measured at end-diastole and early, mid-, and end-systole. Coronary luminal diameter increased 2.1%; luminal area increased 8.1%; arterial area increased 3.7%; and plaque area decreased 4.9% during mid and late systole (p < 0.01). There was no detectable cyclic change in saphenous vein graft dimensions. In coronary arteries there was significant systolic expansion of the artery and lumen and systolic thinning of the plaque. The magnitude of dynamic luminal area change was greater than the variability in measurement and thus warrants gating to the cardiac cycle. The lack of dynamic change in saphenous vein grafts and the relatively small dynamic change in luminal diameter and arterial and plaque areas suggest nominal utility in gating these measurements to the cardiac cycle.
On the application of the Haskind-Hanaoka relations to hydroelasticity problems

Abstract The Haskind-Hanaoka relations for obtaining the wave-exciting forces, given the incoming and radiation potentials in floating rigid-body dynamics, are extended to deformable-body dynamics in the presence of a free surface and within the assumption of linear potentials theory. These relations are applied to the mode-superposition and the direct methods of solution of hydroelasticity problems. In other words, it is shown that regardless of the structural analysis method used in a hydroelasticity problem, the Haskind-Hanaoka relations can be used to calculate the wave-exciting forces without solving for the diffraction potential explicitly. These relations can also be used in the composite singularity distribution method to increase further the computational efficiency.
Using metaprogramming to implement a testing framework

Testing plays an important role in improving software quality. However, test preparation, execution, and report analysis are labor-intensive tasks that require different activities and methods to obtain benefit from the testing process. This poster describes an investigation into the use of metaprogramming, which can reflect the internals of a system, to implement a common test framework that can be used to reduce the burden for test preparation in unit and system testing. The framework focuses on generating instrumented Java bytecode based on several sources of input (e.g., source code or bytecode, and information provided by each test case). Both load-time and compile-time metaprograms are used within the framework to inform the testing process.
Activty Patterns of the Desert Nightsnake (Hypsiglena chlorophaea)

Abstract Data on activity patterns of the desert nightsnake (Hypsiglena chlorophaea) were obtained from 121 specimens. Hypsiglena chlorophaea was active on roads in central Washington during April–October. Specimens were collected at temperatures of 9.1–40.8°C. Males were collected more frequently than females during May, but in equal numbers during June and July, while more females were found in August–September. Hatchling snakes were collected in July–September. Hypsiglena chlorophaea was active 2100-0500 h. Snakes were collected more often during periods of low moon-light (e.g., new moon) than high moon-light (e.g., full moon).
Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI.

Transgenic mice were generated to express a restrictive cardiomyopathy (RCM) human cardiac troponin I (cTnI) R192H mutation in the heart (cTnI193His mice). The objective of this study was to assess...
Effects of monovalent and multivalent ions on the stability of a polyelectrolyte complex with entrapped surfactants

In this article, we report the effects of nine different monovalent and multivalent salts on the particle size and stability of refined, positively charged polyelectrolyte complexes (PECs) with entrapped surfactant. Dynamic light scattering and ζ potential measurements of these polymeric particles as a function of various salt concentrations showed that both counter ions and co-ions induced a concentration-dependent increase in the particle size and a decrease in the ζ potential. We found that the anion concentration where the particle size doubled and the maximum anion concentration beyond which particle precipitation occurred (Ca,max) demonstrated a power law dependence on the anion valence. Moreover, for anions of the same valence but different hydration radio, Ca,max decreased in the following order: NO3 Cl HPO42− > SO42− > PO43−. However, unlike the case of hard colloids where co-ions have relatively little effect on particle interactions, the co-ions also increased the hydrodynamic radii of our PECs in the following order: K+ ≈ Na+ > Ca2+ > Mg2+ > Al3+. Furthermore, we found that the entrapped surfactants were shielded from the adverse effect of multivalent ions; this established that the monovalent and multivalent ions interacted with the polyelectrolyte shells of the PEC. This behavior was in contrast with the effect of salts on mixtures containing the polyelectrolyte and surfactant components, where the addition of salts typically causes an interaction with the individual components. Because several biomedical and technological applications involving PECs require saline environments, our studies provide insight into how small ions influence the PEC stability in applications involving varying salinities. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42099.
Efficient multivariable frequency response computations

An efficient algorithm is presented for the reliable computation of frequency response matrices of the form P(j\omegaI-A)^{-1}Q . Efficiency is achieved through an initial reduction of A to upper Hessenberg form H so that ( j\omegaI-H ) remains upper Hessenberg as ω is varied over a desired range. Linear systems with upper Hessenberg coefficient matrices can then be solved easily and accurately.
Variability in performance of Timed walk tests in pulmonary rehabilitation programs

Study objective: To describe variability in the conduct of walk tests in pulmonary rehabilitation programs. Design: Analysis of information obtained by means of a structured written questionnaire. Setting: Outpatient pulmonary rehabilitation programs in the United States and Canada. Participants: Clinical coordinators of 75 pulmonary rehabilitation programs. Interventions: None Results: Timed walk tests were obtained in 71 of 99 programs surveyed. Considerable variability in all aspects of testing practices was evident. Fifty-seven respondents (80%) based results on a single walk. Walk tests were completed in a hallway (73%), on a walking track (9%), and on a treadmill (7%). In 29 programs (44%), a walk supervisor carried or pulled the oxygen source, while in 25 programs (38%), the oxygen was carried or pulled by the patient. Informal nonstandardized instructions were provided to patients prior to walking in 41 programs (58%). In 53 programs (76%), the walk supervisor could direct a patient to speed up, to slow down, or to rest. Evaluations of breathlessness and perceived exertion were measured during the walk by 73% and 16% of programs, respectively. Conclusions: Practices regarding performance of timed walk tests are poorly standardized among pulmonary rehabilitation programs. Further research is needed to evaluate the impact of certain variations in testing practices on test results. (CHEST 2000; 118:98 ‐105)
Combined digital/wireless link over the multi-mode fiber with a vertical cavity surface emitting laser

In this paper, we present the simultaneous transmission of the baseband digital signal and wireless LAN signal over a multi-mode fiber using a VCSEL. For this hybrid optical link, a new type of combiner is used. For the overall link simulation, a rate-equation based VCSEL model is implemented with circuit components, which describe the high-speed modulation characteristic as well as the thermal effect on the L-I characteristic. The overall optical link is implemented on a Multi-Layer Organic board. An OC-48 baseband data stream and wireless LAN (802.11a) signal at 5.8GHz are applied to the link and successfully transmitted. To the best knowledge of the authors, this is the first demonstration of VCSEL technology for a hybrid optical link.
Adrenal lipid and alkaline phosphatase in hamsters infected with Leishmania donovani.

CPIANGES in adrenal size (Selye, 1936; Tepperman, Engel and Long, 1942; Chan, 1950) sudanophilic lipid (Selye, 1936; Zwemer, 1936; Knouff, Brown and Schneider, 1941; Dosne and Dalton, 1941; Darrow and Sarason, 1944) cholesterol (Popjack, 1944; Levin, 1945; Ludewig and Chanutin, 1947; Fortier et al, 1950) and ascorbic acid (Sayers and Sayers, 1948) are induced by stress. In this regard, chronic infections may serve as a continuous stress and thus influence the functional activity of the adrenal cortex. In general, adrenal hypertrophy and a loss in lipid accompanies prolonged infections (Deanesly, 1931; Menten and Smith, 1936). More recently, Sayers and his co-workers (1944) have shown that infectious diseases will deplete the adrenal gland of cholesterol and may favor adrenal exhaustion (Long, 1947; Pinchot, Close and Long, 1949). Attention was drawn to the possible involvement of the adrenal gland in the death of Golden hamsters {Mesocricetus auratus) infected with Leishmania donovani as many hamsters exh...
RELATIVE POTENCY OF ORG NC 45, PANCURONIUM, ALCURONIUM AND TUBOCURARINE IN ANAESTHETIZED MAN

SUMMARY The relative potency, time-course of action and cardiovascular effects of Org NC 45, a new non-depolarizing neuromuscular blocking agent, have been compared with those of pancuronium, alcuronium and tubocurarine in 64 anaesthetized patients. The relative potency (ED50) to Org NC45 was 1.74, 3.69 and 8.57 respectively. In doses which caused useful surgical relaxation, duration of action of Org NC 45 was 34%, 39% and 26% that of pancuronium, alcuronium and tubocurarine. After administration of repeated doses no cumulation was seen for Org NC 45. The new drug was free from any effect on arterial pressure and heart rate.
Instantaneous and local wavenumber estimations for damage quantification in composites

The continued and expanded use of composite materials in aerospace applications necessitates structural health monitoring and/or nondestructive evaluation techniques that can provide quantitative a...
Mixed carcinoma in situ: an immunohistochemical study

A case of mixed carcinoma in situ, of the skin, is presented. The lesion, located on the right temple of a 71-year-old man, showed histologic features of Bowen's disease and extramammary Paget's disease. This case suggests that Bowen's disease and extramammary Paget's disease may arise from pluripotential adnexal epithelium capable of keratinocytic and glandular differentiation. Utilization of the peroxidase-antiperoxidase technique for demonstrating carcino-embryonic antigen was performed in order to identify the component interpreted as extramammary Paget's disease. This procedure is apparently more sensitive than the commonly employed histochemical stains for demonstrating glandular differentiation.
The use of atomic level stress to characterize the structure of irradiated iron

The behaviour of irradiated material near a primary knock on atom immediately after impact is of great importance for designing reactor materials. Currently, molecular dynamics simulations with classical force fields provide the foundation for understanding the resulting cascade. However, modern density functional calculations can now treat large enough numbers of atoms that they can provide additional details of the magnetic and electronic nature of irradiated samples. In this paper we calculate from first principles the atomic level stresses for an instantaneous configuration following the initiation of a low energy cascade in iron.
A randomized phase II clinical trial of high-dose nicotine patch therapy for smokeless tobacco users.

Introduction: Nicotine patch therapy has not been shown to be efficacious for increasing long-term (≥6 months) tobacco abstinence rates among smokeless tobacco (ST) users. Higher doses of nicotine patch therapy may be needed to increase tobacco abstinence rates in this population of tobacco users.
The Ideology of the Dual City: The Modernist Ethic in the Corporate Development of Makati City, Metro Manila.

ijur_1100 165..185 Postcolonial cities are dual cities not just because of global market forces, but also because of ideological currents operating through local real-estate markets — currents inculcated during the colonial period and adapted to the postcolonial one. Following Abidin Kusno, we may speak of the ideological continuity behind globalization in the continuing hold of a modernist ethic, not only on the imagination of planners and builders but on the preferences of elite consumers for exclusive spaces. Most of the scholarly work considering the spatial impact of corporate-led urban development has situated the phenomenon in the ‘global’ era — to the extent that the spatial patterns resulting from such development appear wholly the outcome of contemporary globalization. The case of Makati City belies this periodization. By examining the development of a corporate master-planned new city in the 1950s rather than the 1990s, we can achieve a better appreciation of the influence of an enduring ideology — a modernist ethic — in shaping the duality of Makati.
Modeling the effects of memory on human online sentence processing with particle filters

Language comprehension in humans is significantly constrained by memory, yet rapid, highly incremental, and capable of utilizing a wide range of contextual information to resolve ambiguity and form expectations about future input. In contrast, most of the leading psycholinguistic models and fielded algorithms for natural language parsing are non-incremental, have run time superlinear in input length, and/or enforce structural locality constraints on probabilistic dependencies between events. We present a new limited-memory model of sentence comprehension which involves an adaptation of the particle filter, a sequential Monte Carlo method, to the problem of incremental parsing. We show that this model can reproduce classic results in online sentence comprehension, and that it naturally provides the first rational account of an outstanding problem in psycholinguistics, in which the preferred alternative in a syntactic ambiguity seems to grow more attractive over time even in the absence of strong disambiguating information.
Specific auditory memory induced by nucleus basalis stimulation depends on intrinsic acetylcholine

Although the cholinergic system has long been implicated in the formation of memory, there had been no direct demonstration that activation of this system can actually induce specific behavioral memory. We have evaluated the "cholinergic-memory" hypothesis by pairing a tone with stimulation of the nucleus basalis (NB), which provides acetylcholine to the cerebral cortex. We found that such pairing induces behaviorally-validated auditory memory. NB-induced memory has the key features of natural memory: it is associative, highly-specific and rapidly induced. Moreover, the level of NB stimulation controls the amount of detail in memory about the tonal conditioned stimulus. While consistent with the hypothesis that properly-timed release of acetylcholine (ACh) during natural learning is sufficient to induce memory, pharmacological evidence has been lacking. This study asked whether scopolamine, a muscarinic antagonist, impairs or prevents the formation of NB-induced memory. Adult male rats were first tested for responses (disruption of ongoing respiration) to tones (1-15 kHz), constituting a pre-training behavioral frequency generalization gradient (BFGG). Then, they received a single session of 200 trials of a tone (8.00 kHz, 70 dB, 2 s) paired with electrical stimulation of the NB (100 Hz, 0.2 s). Immediately after training, they received either scopolamine (1.0 mg/kg, i.p.) or saline. Twenty-four hours later, they were tested for specific memory by obtaining post-training BFGGs. The saline group developed CS-specific memory, manifested by maximum increase in response specific to the CS frequency band. In contrast, the scopolamine group exhibited no such memory. These findings indicate that NB-induced specific associative behavioral memory requires the action of intrinsic acetylcholine at muscarinic receptors, and supports the hypothesis that natural memory formation engages the nucleus basalis and muscarinic receptors.
A small, cheap, and portable reconnaissance robot

While there is much interest in human-carriable mobile robots for defense/security applications, existing examples are still too large/heavy, and there are not many successful small human-deployable mobile ground robots, especially ones that can survive being thrown/dropped. We have developed a prototype small short-range teleoperated indoor reconnaissance/surveillance robot that is semi-autonomous. It is self-powered, self-propelled, spherical, and meant to be carried and thrown by humans into indoor, yet relatively unstructured, dynamic environments. The robot uses multiple channels for wireless control and feedback, with the potential for inter-robot communication, swarm behavior, or distributed sensor network capabilities. The primary reconnaissance sensor for this prototype is visible-spectrum video. This paper focuses more on the software issues, both the onboard intelligent real time control system and the remote user interface. The communications, sensor fusion, intelligent real time controller, etc. are implemented with onboard microcontrollers. We based the autonomous and teleoperation controls on a simple finite state machine scripting layer. Minimal localization and autonomous routines were designed to best assist the operator, execute whatever mission the robot may have, and promote its own survival. We also discuss the advantages and pitfalls of an inexpensive, rapidly-developed semi-autonomous robotic system, especially one that is spherical, and the importance of human-robot interaction as considered for the human-deployment and remote user interface.
Coated-platelet levels are elevated in patients with transient ischemic attack

Transient ischemic attack (TIA) presents a medical management dilemma because of the high frequency of subsequent ischemic strokes. The ABCD2 score is designed to stratify the short-term risk for stroke in TIA patients. Coated-platelets, which are a subset of procoagulant platelets observed after dual agonist stimulation with collagen and thrombin, are increased in cortical ischemic stroke and decreased in spontaneous intracerebral hemorrhage. Because TIA increases the risk of subsequent ischemic stroke, we conducted a pilot study to investigate whether coated-platelet production is increased in patients with TIA (n = 60) compared with controls (n = 60). Coated-platelet levels were higher in TIA patients versus controls [mean ± standard deviation (SD), 38.4 ± 15.1% vs 31.0 ± 13.2%, P = 0.005], and a significant linear correlation was detected between ABCD2 scores and coated-platelet levels in TIA patients (P = 0.0003, r = 0.45). These findings lend support to the hypothesis that TIA and ischemic stroke represent a spectrum of conditions dependent on similar prothrombotic processes.
Use of Contralateral Masking in the Measurement of the Auditory Brainstem Response

In the first portion this study, the effects of two levels of contralateral masking on the auditory brainstem response (ABR) were investigated in 10 normal-hearing subjects. No significant changes ...
Money as metaphor

Purpose – The purpose of this study is to examine two rival narratives regarding the nature and evolution of money with reference to metaphor. Design/methodology/approach – The article draws on theoretical literature on money. Post-Keynesian perspectives are given consideration due to the particular attention that this school has given to money. Findings – A crucial divide in the understanding of money is interpreted in terms of two different narratives. We conclude that the narrative of money as credit has greater explanatory power, but that the commodity narrative, which is metaphorical in nature, is easier to comprehend and conceptualize. Research limitations/implications – This study has been qualitative in nature; further research would require specification of a linguistic methodology, including selection and analysis of a corpus. A process for detecting metaphors within a selected corpus would also need to be established. Moreover, the discussion of the commodity metaphor as a normative theory has ...
Lagrangian simulation of dispersion in turbulent shear flow with a hybrid computer

Two-dimensional turbulent diffusion is modeled with a generalized Langevin equation. Instantaneous velocities are simulated by using white noise filtered to simulate turbulence. By generating fluctuating signals that are partially correlated, it is possible to model diffusion for a turbulent shear field. The result show that the dispersion is independent of shear for long and short diffusion times but depend strongly on shear for intermediate times.
Auditors As Advocates For Their Clients: Perceptions Of The Auditor-Client Relationship

Recently auditors have come under increasing criticism for appearing to act as advocates on behalf of their audit clients. Such criticisms strike at the very heart of the public accounting profession the publics trust of the auditors. Given the considerable importance of this issue we conducted a survey of one national accounting firms auditing managers and senior managers to ascertain their attitudes regarding such advocacy. Results suggest that some members of the firm view their role somewhat differently than the traditional watchdog role commonly ascribed to them. Implications of our study as well as suggestions for future research are discussed.
Superconducting magnets

Although small superconducting magnets have been in regular use in many laboratories for several years, it is only recently that the technical difficulties preventing the use of superconductors in large magnet systems have been overcome. A better understanding of the transient thermal and magnetic behavior of such devices has led to various methods of reducing or eliminating the degradation effects present in earlier magnets. The use of large amounts of very high conductivity normal metal in conjunction with the superconductor has resulted in "stabilized" magnets whose behavior is completely predictable and which will not quench except under unusual conditions. Other techniques have been developed to improve "unstable" magnets so that very high field coils can be constructed. These developments are dramatically altering the equipment used in high-energy physics and controlled thermonuclear experiments, and their effect on other areas of technology is already beginning to be felt.
Quality of life after laparoscopic cholecystectomy for biliary dyskinesia in the pediatric population: a pilot study.

Abstract This pilot study examined symptom relief and quality of life in pediatric patients who received laparoscopic cholecystectomy surgery at our institution for biliary dyskinesia. We used two validated questionnaires: the Child Health Questionnaire (CHQ-PF28), to assess general well-being, and the Gastrointestinal Quality of Life Index (GIQLI), to measure gastrointestinal-related health. After Institutional Review Board approval, all patients under the age of 18 years who underwent laparoscopic cholecystectomy for biliary dyskinesia between November 2006 and May 2010 received mailed questionnaires. Preoperative and postoperative data were retrospectively collected from respondents and included age, race, symptoms, gallbladder ejection fraction values, pathologic findings, and clinical course. Of 89 patients meeting inclusion criteria, 21 responded. Mean age at surgery was 13.08 years (range, 8 to 17 years). The most common preoperative symptoms consisted of nausea (100%), postprandial pain (90.5%), right upper quadrant pain (81.0%), and vomiting (66.7%). Mean long-term follow-up interval was 18.9 months (range, 7 to 40 months; SD 10.37). Patients with long-term symptom relief reported significantly higher GIQLI scores than those with enduring symptoms. Examination of the results from the CHQ-PF28 revealed significantly lower scores than a general U.S. pediatric sample in both the Physical and Psychosocial Summary Measures (P < 0.05). Children experiencing long-term symptom cessation after laparoscopic cholecystectomy reported higher quality of life than those who had incomplete or only short-term relief. However, regardless of the degree of symptom relief, the degree of quality of life experienced by our study sample of patients with biliary dyskinesia is lower than that of a comparable U.S. pediatric sample.
Lowrank Finite-differences For Wave Extrapolation

We introduce a novel finite-difference approach for seismic wave extrapolation in time. Compared with those of conventional finite-difference (FD) methods, the coefficients of the new method are variables in space. We derive the finitedifference operator from a lowrank approximation of the space-wavenumber, wave-propagator matrix. We present a mathematical derivation of this method. Numerical examples confirm the validity of the proposed technique. The lowrank FD method can be applied to enhancing accuracy and stability in seismic imaging by reverse-time migration.
The Performance Characteristic Analysis of Transformer Differential Protection in a Complex Fault Condition

This paper introduced and diagnosed a complex transformer short circuit fault in which one fault point was at the internal zone and the other fault point was at the external zone of the transformer.It analyzed the current and the performance characteristic of transformer differential protection in fault condition.Fault types were identified according to field recording waveforms.And the problems that should be paid attention to during the fault debugging and location were brought forward.
A Factor Analysis of the Latent Structure in a Set of Random Numbers or, How to Find Structure Where None Exists

Conventional factor analysis, using decision rules common to the literature, is applied to a set of 22 variables generated with no intercorrelations. Interpretable factors result. An augmented analysis is applied to the same factor structure. No interpretable factors are found. This study presents a number of easily understood and simply applied safeguards which researchers may wish to use to avoid inferring a factor structure where none exists.
Quantum computing and second quantization

Quantum computers by their nature are many particle quantum systems. Both the many-particle arrangement and being quantum are necessary for the existence of the entangled states, which are responsible for the parallelism of the quantum computers. Second quantization is a very important approximate method of describing such systems. This lecture will present the general idea of the second quantization, and discuss shortly some of the most important formulations of second quantization.
CRISPR-Mediated Knockout of Cybb in NSG Mice Establishes a Model of Chronic Granulomatous Disease for Human Stem-Cell Gene Therapy Transplants

Chronic granulomatous disease (CGD) is characterized by defects in the production of microbicidal reactive oxygen species (ROS) by phagocytes. Testing of gene and cell therapies for the treatment of CGD in human hematopoietic cells requires preclinical transplant models. The use of the lymphocyte-deficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mouse strain for human hematopoietic cell xenografts to test CGD therapies is complicated by the presence of functional mouse granulocytes capable of producing ROS for subsequent bacterial and fungal killing. To establish a phagocyte-defective mouse model of X-linked CGD (X-CGD) in NSG mice, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 was utilized for targeted knockout of mouse Cybb on the X-chromosome by microinjection of NSG mouse zygotes with Cas9 mRNA and CRISPR single-guide RNA targeting Cybb exon 1 or exon 3. This resulted in a high incidence of indel formation at the CRISPR target site, with all mice exhibiting deletions in at lea...
Exploring Design Opportunities for a Context-Adaptive Medical Checklist Through Technology Probe Approach

This paper explores the workflow and use of an interactive medical checklist for trauma resuscitation--an emerging technology developed for trauma team leaders to support decision making and task coordination among team members. We used a technology probe approach and ethnographic methods, including video review, interviews, and content analysis of checklist logs, to examine how team leaders use the checklist probe during live resuscitations. We found that team leaders of various experience levels use the technology differently. Some leaders frequently glance at the checklist and take notes during task performance, while others place the checklist on a stand and only interact with the checklist when checking items. We compared checklist timestamps to task activities and found that most items are checked off after tasks are performed. We conclude by discussing design implications and new design opportunities for a future dynamic, adaptive checklist.
Selecting the Qualified: A Standards-Based Teacher Education Admission Process

A standards-based admission process for qualifying caring and competent candidates for teacher preparation is presented. The major elements of the admission process include prerequisite standards that address the knowledge, dispositions, and skills candidates should possess upon entrance to the teacher education program; multiple assessments that evaluate the prerequisite standards; and an admission interview process that involves collaboration of arts and sciences faculty, education faculty, undergraduate students, and professionals from the field. A unique aspect of the admission process is its strong focus on dispositional standards. Emphasis is placed on qualifying future teachers into teacher education programs based upon demonstrated evidence of their meeting defensible and education community supported admission standards.
Philadelphia chromosome-like acute lymphoblastic leukemia: progress in a new cancer subtype.

Abstract Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a newly described, high-risk subtype of B-cell ALL. It is characterized by a gene expression profile similar to that of Ph-positive ALL; however, the BCR-ABL1 fusion is not present. The World Health Organization classification of myeloid neoplasms and acute leukemia recently was updated to include the Ph-like or BCR-ABL1-like ALL subtype of B-cell ALL as a provisional entity. Unlike Ph-positive ALL, which is characterized by the pathognomonic BCR-ABL1 fusion, Ph-like ALL is characterized by a multitude of different genetic rearrangements and mutations. In this review, we outline the age-related and geographic incidence of Ph-like ALL, the association with worse clinical outcomes, and early evidence for the use of ruxolitinib (a Janus kinase 2 inhibitor) and dasatinib (a tyrosine kinase inhibitor targeting ABL1).
Zipped Commercials, Zapped Memory? Not Necessarily

As digital-video-recorders (DVRs) become more popular, an increasing number of television commercials are being zipped (fast-forwarded). This paper examines how memory for brand names, products and attitudes toward commercials are influenced by zipping at the speeds used by the popular DVR manufacturer, TiVo (300, 1800 and 6000 percent). Experimental results show that compared to ads shown in real-time, memory for the advertised brand names improves when the commercials are zipped at 300 percent of normal speed. However, brand name recall dramatically declines as the commercials are zipped at faster speeds (1800 and 6000 percent). Speed of zipping had a significant effect on the ability to recall the advertised brand for all commercials except those at the end of a commercial pod. This suggests that all else being equal, ads placed at the end of a commercial pod are more likely to be recalled at all zipping speeds. Viewers of zipped commercials had more neutral attitudes toward the ads compared with those who saw them in real-time.
Non-equilibrium wetting and capture of boron nitride nanotubes in molten aluminum during plasma spray

Abstract Boron Nitride Nanotube (BNNT) is integrated into Aluminum (Al) matrix by plasma spray, involving non-equilibrium solidification. A wet chemistry approach is adopted to obtain Al-BNNT powder feedstock, which is plasma sprayed to form Al-BNNT composite. BNNTs survive the harsh and reactive conditions in plasma and are uniformly distributed in Al matrix. Trace amounts of AlN and AlB2 formed due to Al-BNNT reactions act as covalently bonded interfacial anchors. Rapid solidification enables efficient capture of BNNT in the molten Al due to viscous drag. BNNT improves the stiffness and hardness of the composite, acting as an effective mechanical reinforcement.
Linking practice and classroom: Nonprofit financial management curricula in MPA and MPP programs

ABSTRACTThere is a growing interest in the nonprofit sector among the students and graduates of Master of Public Administration (MPA)/Master of Public Policy (MPP) programs. In response, curricula ...
United States Pollution Intensive Trade Trends From 1972 to 1992

Goods which are pollution intensive in production may be increasingly imported as the United States' income grows, trade barriers fall, and environmental regulation increases. This paper studies trends in United States bilateral trade patterns to test whether the United States has increased its imports of dirty manufacturing relative to clean manufacturing and whether imports of pollution intensive goods from poorer nations have increased from 1972 to 1992. Little evidence in favor of the "pollution havens" hypothesis is found.
Medical management of Mild and Moderate Vesicoureteral Reflux: Followup Studies of Infants and Young Children. A Preliminary Report of the Southwest Pediatric Nephrology Study Group

AbstractMild and moderate vesicoureteral reflux is expected to resolve spontaneously in most children treated medically; however, maximum benefit or minimum risk of such therapy has not been defined. A prospective 5-year followup study of infants and children younger than 5 years at entry with primary vesicoureteral reflux (grades I to III/V) and radiographically normal kidneys after the first recognized urinary tract infection was initiated in 1984. A total of 113 patients was entered from 5 centers and 61% of the patients were less than 2 years old. Vesicoureteral reflux was unilateral in 65 cases (58%) and bilateral in 48 (42%). Of the 226 renal units reflux was grade IV in 4 (2%), III in 51 (22%), II in 81 (36%) and I in 25 (11%), and 65 (29%) had no vesicoureteral reflux. Data on 59 patients who have completed the protocol were analyzed for this report.Breakthrough urinary tract infection occurred in 20 patients. Of the 84 ureters with vesicoureteral reflux at diagnosis reflux resolved in 67%, and it...
Scout: a simple game-searching algorithm with proven optimal properties

This paper describes a new algorithm for searching games which is conceptually simple, space efficient, and analytically tractable. It possesses optimal asymptotic properties and may offer practical advantages over α-β for deep searches.
What really determines the height in column flotation

Flotation columns and their variations are increasingly replacing conventional cells in mineral-processing circuits. While the operational characteristics of columns differ from those of conventional cells, the same scale-up methodologies are being employed. This practice may be attributed to a poor understanding of the factors that control throughput. The use of tall flotation columns is frequently justified because of the need for an increased particle residence time. However, it is shown that longer particle residence times alone do not translate into increased recoveries. In this paper, throughput data from several industrial flotation-column installations is presented. Also, an attempt is made at using dimensional analysis to provide a scale-up methodology for the factors controlling column throughput.
The Copyright Office and Their Digital Music Licensing Study: An Analysis of Comments

In early 2015, the Copyright Office issued a study that was the result of two rounds of comments that were made in response to a Notice of Inquiry (NOI) seeking information regarding a series of questions about digital music licensing. The study was needed as digital music distribution has become both increasingly prevalent and difficult to reconcile using present statutes. One specific item that the questions in the NOI sought information on, was the current state of the sound recording (SR) copyright, which is a separate right to ownership from the musical composition. This project is concerned with the shape of the discourse between the copyright office and the parties that submitted feedback in both rounds of comments, which comprises a complex communication route involving the commenters and copyright office. Furthermore, though, the filters put in place by the copyright office that allowed certain comments through to the final recommendation document represent a gatekeeper function. Ultimately, if the Copyright Act itself is changed at all to reflect the work of this study, then that gatekeeper role is highly important and must be analyzed for biases.
Providing primary care to transgender patients

Lara (not an actual patient), a 45-year-old transwoman, presents to your clinic for a yearly check-up. She has no significant medical history except for asthma. Her surgical history includes appendectomy and breast augmentation. Family history is significant for a mother who developed breast cancer
RDMTk: A Toolkit for Risky Decision Making

Research into risky decision making (RDM) has become a multidisciplinary effort. Conversations cut across fields such as psychology, economics, insurance, and marketing. This broad interest highlights the necessity for collaborative investigation of RDM to understand and manipulate the situations within which it manifests. A holistic understanding of RDM has been impeded by the independent development of diverse RDM research methodologies across different fields. There is no software specific to RDM that combines paradigms and analytical tools based on recent developments in high-performance computing technologies. This paper presents a toolkit called RDMTk, developed specifically for the study of risky decision making. RDMTk provides a free environment that can be used to manage globally-based experiments while fostering collaborative research. The incorporation of machine learning and high-performance computing (HPC) technologies in the toolkit further open additional possibilities such as scalable algorithms and big data problems arising from global scale experiments.
Communicating racial segregation: Abstract versus concrete.

In PNAS, Olteanu et al. (1) introduce a framework for analyzing racial segregation. What distinguishes their method is the high level of mathematical abstraction used to yield a result. We note that Olteanu et al. (1) do not compare the utility of their method to that of existing, more concrete methods (2, 3). In our view, the method based on classifying population units on the basis of racial diversity/dominant race (3) provides more insight to all stakeholders in the problem of racial segregation in a much more accessible fashion. The Olteanu et al. (1) method employs a street-view perspective of segregation in which inhabitants explore their city starting from their residence and record a … [↵][1]1To whom correspondence may be addressed. Email: stepintz{at}uc.edu. [1]: #xref-corresp-1-1
Injury and Injustice

This review examines the state of scholarship on the politics of injury law, a relatively neglected field. I argue that injury law is an important site of political contestation, particularly for s...
Insight into microstructure-sensitive elastic strain concentrations from integrated computational modeling and digital image correlation

Abstract The microstructural origins of highly localized elastic strain concentrations in polycrystalline microstructures under monotonic loading are studied using grain-scale, in situ digital image correlation and crystal plasticity finite element method. It is shown that the locations of exceptionally high elastic strain concentrations in the microstructure depend on particular crystallographic and morphological orientations of grains and less so on crystalline details of their local neighborhood. Based on these results, we discuss how topological and crystallographic features of annealing twin boundaries can increase the likelihood of slip band initiation throughout the microstructure of polycrystalline Ni-base superalloys.
Small Survey Event Detection.

A small survey on event detection using Twitter. This work first defines the problem statement, and then summarizes and collates the different research works towards solving the problem.
Between Order and Execution: A Phenomenological Approach to the Role of Relationships in Military Culture

Despite the growing recognition that military identity and veteran identity are interrelated, there is scant literature that seeks to describe or define military culture—perhaps an indication of the degree to which veterans and civilians alike take military culture for granted as a factor in veteran identity. One important factor in veteran identity is relationship: relationships amongst veterans and between veterans and civilians. In the latter case, trust is often wanting, and that lack of trust seems to be connected to the experience of military service. To explore a possible connection between military culture and veteran experience, in-depth interviews were conducted with a diverse group of veterans to develop an understanding of the phenomenon of relationship, or relationality, within military service. Close attention was paid to the daily routines and rhythms of military life. Veterans were given wide latitude to discuss both the positive and negative relationships that they regarded as key to their military experience. The results, presented here as case studies, suggest that relationships of trust in military service often develop out of routine training experiences and are grounded in unique military expectations regarding the public performance of common skills. This phenomenological study is a first step in developing a more comprehensive understanding of the many ways that military experiences may become veteran expectations with respect to relational ideas such as trust.