cssi/SciSciGPT-SciSciNet huggingface dataset:
Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein-protein interactions directly from DNA.

Assays that integrate detection of binding with cell-free protein expression directly from DNA can dramatically increase the pace at which protein–protein interactions (PPIs) can be analyzed by mutagenesis. In this study, we present a method that combines in vitro protein production with an enzyme-linked immunosorbent assay (ELISA) to measure PPIs. This method uses readily available commodity instrumentation and generic antibody–affinity tag interactions. It is straightforward and rapid to execute, enabling many interactions to be assessed in parallel. In traditional ELISAs, reporter complexes are assembled stepwise with one layer at a time. In the method presented here, all the members of the reporter complex are present and assembled together. The signal strength is dependent on all the intercomponent interaction affinities and concentrations. Although this assay is straightforward to execute, establishing proper conditions and analysis of the results require a thorough understanding of the processes that determine the signal strength. The formation of the fully assembled reporter sandwich can be modeled as a competition between Langmuir adsorption isotherms for the immobilized components and binding equilibria of the solution components. We have shown that modeling this process provides semiquantitative understanding of the effects of affinity and concentration and can guide strategies for the development of experimental protocols. We tested the method experimentally using the interaction between a synthetic ankyrin repeat protein (Off7) and maltose-binding protein. Measurements obtained for a collection of alanine mutations in the interface between these two proteins demonstrate that a range of affinities can be analyzed.
Correcting for Endogeneity in Strategic Management Research

The field of strategic management is predicated fundamentally on the idea that managements' decisions are endogenous to their expected performance implications. Yet, based on a review of more than a decade of empirical research in the Strategic Management Journal, we find that few papers econometrically correct for such endogeneity. In response, we now describe the endogeneity problem for cross-sectional and panel data, referring specifically to management's choice among discrete strategies with continuous performance outcomes. We then present readily implementable econometric methods to correct for endogeneity and, when feasible, provide STATA code to ease implementation. We also discuss extensions and nuances of these models that are sometimes difficult to decipher in more standard treatments. These extensions are not typically discussed in the strategy literature, but they are, in fact, highly pertinent to empirical strategic management research.
Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity purification (TRAP) permits comprehensive studies of translated mRNAs in genetically defined cell populations after physiological perturbations. To establish the generality of this approach, we present translational profiles for 24 CNS cell populations and identify known cell-specific and enriched transcripts for each population. We report thousands of cell-specific mRNAs that were not detected in whole-tissue microarray studies and provide examples that demonstrate the benefits deriving from comparative analysis. To provide a foundation for further biological and in silico studies, we provide a resource of 16 transgenic mouse lines, their corresponding anatomic characterization, and translational profiles for cell types from a variety of central nervous system structures. This resource will enable a wide spectrum of molecular and mechanistic studies of both well-known and previously uncharacterized neural cell populations.
Moral Combat in An Enemy of the People: Public Health versus Private Interests

Dr Thomas Stockmann, the protagonist of Ibsen's play, An Enemy of the People, discovers a serious health threat in the Baths of his Norwegian town. The Baths have been marketed as a health resort to lure visitors. Dr Stockmann alerts officials about the problem and assumes that they will close the Baths until it is corrected. He is met with fierce resistance, however. His brother, the town's mayor, favors keeping the Baths open and correcting the problem gradually. He advances multiple arguments that appeal to the economic interests of the town and Thomas's role-related obligation as a citizen. His wife, Katherine, wants him to cooperate with the mayor. She marshals several arguments that appeal to his obligations as a father. This paper reconstructs and examines the competing arguments, shows how Ibsen's play has both contemporary relevance and moral depth, and demonstrates how Dr Stockmann's responses can be interpreted as an argument that complying with his duties to protect the public health do not force him to renege on his core commitments as a parent and as a citizen.
Climb‐Dissociated Dislocations in Monazite at Low Temperature

Three types of climb-dissociated partial dislocations were observed by high-resolution transmission electron microscopy in monazite (LaPO4) that was indented at room temperature. Two types were found on twin boundaries, and a third in the lattice. Formation mechanisms are discussed. Glide of climb-dissociated partial dislocations that is allowed by stacking fault migration is considered.
Mathematical Models for Hantavirus Infection in Rodents

Hantavirus pulmonary syndrome is an emerging disease of humans that is carried by wild rodents. Humans are usually exposed to the virus through geographically isolated outbreaks. The driving forces behind these outbreaks is poorly understood. Certainly, one key driver of the emergence of these viruses is the virus population dynamics within the rodent population. Two new mathematical models for hantavirus infection in rodents are formulated and studied. The new models include the dynamics of susceptible, exposed, infective, and recovered male and female rodents. The first model is a system of ordinary differential equations while the second model is a system of stochastic differential equations. These new models capture some of the realistic dynamics of the male/female rodent hantavirus interaction: higher seroprevalence in males and variability in seroprevalence levels.
An efficient strategy for utilizing a merit function in nonlinear programming algorithms

where f : f1~ n + ~'~ and G : A n ~ m are smooth, the method of sequential quadratic programming (SQP) has been shown to generate good step directions for computing iterative approximations to the solution. However, the best choice of a merit, or line search, function with which to determine the appropriate step length so as to guarantee rapid convergence is still a matter of some debate. (See, for example, [ChaLPP82], [Han77], BogT84], [Pow85], [Seh83].) The research of the authors has centered on a merit function of the form
Striking Deaths: Lethal Contestation and the “Exceptional” Character of the American Labor Movement, 1870–1970

The decades between the Great Railway Strike of 1877 and the post-World- War-II institutionalization of organized labor in the US have been impressionistically characterized by labor scholars as the most violent and bloody to be found in any Western, democratic nation. A variety of different forms of labor repression have been identified and studied. Yet because of a lack of systematic data, none have been able to examine directly the incidence and contours of the ultimate form of violent repression in collective contention. We create the conceptual space for pursuing bloodshed and a new data set featuring deaths resulting from labor strikes as a new and promising direction in the American exceptionalism debate and in studies of comparative strikes. Through a painstaking search of the historical record, we produce the first systematic quantitative gauge of striking deaths between 1870 and 1970. These data permit a mapping of fatalities resulting from labor strikes across time, geographical region, and industry. After describing configurations of strike-based mortality, we suggest what these patterned variations may mean and identify additional questions that these data may help resolve in subsequent studies. We urge comparable data collections in other countries that would permit direct comparative-historical assessments of the magnitude and role of bloodshed in different labor movements.
Component-based locomotion composition

When generating locomotion, it is particularly challenging to adjust the motion's style. This paper introduces a component-based system for human locomotion composition that drives off a set of example locomotion clips. The distinctive style of each example is analyzed in the form of sub-motion components decomposed from separate body parts via independent component analysis (ICA). During the synthesis process, we use these components as combinatorial ingredients to generate new locomotion sequences that are stylistically different from the example set. Our system is designed for novice users who do not have much knowledge of important locomotion properties, such as the correlations throughout the body. Thus, the proposed system analyzes the examples in a unsupervised manner and synthesizes an output locomotion from a small number of control parameters. Our experimental results show that the system can generate physically plausible locomotion in a desired style at interactive speed.
U.S. DoD Applications of Ion Beam Processing

Selected usages of ion beam processes within the U.S. Department of Defense (DoD) are discussed in terms of their technical merits, their current status, and the various factors governing their acceptance within the DoD user community.
The Hinge Civil Society, Group Culture, and the Interaction Order

Although often perceived as distant, social psychology and political sociology have much to offer each other. I build upon a meso-level analysis to examine how groups provide the basis for involvem...
Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury

The objective of the present study was to directly compare levels of chondrocyte apoptosis produced by osteochondral injury in vivo and in vitro. Adult New Zealand White rabbits underwent 2 mm osteochondral drilling of the medial and lateral femoral condyles of a single hind limb. Animals were euthanized, and specimens were harvested at 0, 2, 4, 7, 10, and 14 days following injury. At the time of euthanasia, identical injuries were created in the femoral condyles of the contralateral hind limb. These condyles were maintained in vitro under standard tissue culture conditions until harvesting at time points corresponding to the in vivo specimens (i.e. after 0, 2, 4, 7, 10 and 14 days in culture). The extent of apoptosis in the in vivo and in vitro specimens was quantified by TUNEL analysis. The amount and distribution of TUNEL positive cells followed similar patterns in both in vivo and in vitro specimens with a maximal percentage of apoptotic chondrocytes observed on post-injury day 4. On post-injury day 4, in vivo specimens displayed a statistically significant increased overall level of apoptosis compared to in vitro specimens [in vivo=32.5+/-8.6%; in vitro=22.2+/-4.8%; (p=0.03)]. These experiments suggest that the majority of programmed cell death observed after osteochondral injury can be attributed to processes intrinsic to the cartilage itself; however, additional factors present within the acutely traumatized joint also appear to potentiate chondrocyte apoptosis following injury.
Acetaminophen and low-flow myocardial ischemia: efficacy and antioxidant mechanisms.

In the current study, the cardioprotective efficacy of 0.35 mmol/l acetaminophen administered 10 min after the onset of a 20-min period of global, low-flow myocardial ischemia was investigated. Mat...
Motivating Customers to Adhere to Expert Advice in Professional Services A Medical Service Context

This study focuses on the mechanisms by which professional service providers effectively influence customers to adhere to their expert guidance and advice. Eliciting customer adherence is a critical concern for professional service firms since customers of these need-based (rather than want-based) services are often reluctant to adhere, and nonadherence can result in serious negative consequences to customer well-being and firm resource utilization. The study examines this scenario by developing a conceptual framework that integrates the following three theoretical areas: professional services theory, advice utilization theory, and social cognitive theory. The framework proposes associations between professional service provider actions and customer reactions, including adherence to expert advice, adherence intentions, and organizational resources needed to serve the customer (time cost and monetary cost). The study empirically tests the hypothesized relationships based on professional service provider-cu...
Steady-State Flow-Force Compensation in a Hydraulic Spool Valve

A high-speed jet flowing inside of a partially-open hydraulic valve is accompanied by a reaction force, also referred to as flow force. The nature of this force has remained a mystery despite an extensive research effort spanning many decades. The momentum theory on the flow force by Lee and Blackburn (1952) explains the origin of the flow force and offers a design solution to shape the valve spool as a turbine bucket. It provides a model to calculate the compensated flow force as well. This paper shows that the model applies to a different flow case due to incorrect assumptions made. A corrected equation is presented based on a detailed analysis of the static-pressure distribution in the valve cavity as well as on a literature review of pressure loss in diffusers and nozzles. The new equation is based on the compensation taking place upstream of the valve orifice, not downstream as assumed by the momentum theory. The new model can be applied to chamfers or notches on the valve spool without the need to machine a complete turbine-bucket profile. Keywords: flow force, flow-force compensation, hydraulic valve design, control volume, fluid momentum, pressure loss, nozzles, diffusers, CFD.
Objective-driven and Pareto Front Analysis: Optimizing Time, Cost, and Job-site Movements.

Abstract Finding the optimized trade-off relationship between cost and time, two important objectives of construction projects, helps project managers and their teams select a more suitable schedule for a given project. This trade-off relationship can roughly be estimated using past and cumulative knowledge, but since the early 1970s, researchers have been working on a systematic and mathematical solution to define this relationship more accurately. These researchers have used different optimization techniques such as the genetic algorithm (GA), ant colony, and fuzzy logic to further explore the relationship. In the present paper, the authors have used their previously introduced construction schedule generator algorithm to present graphical relationships between pre-defined objectives of schedule optimizations. The process starts with developing construction schedules from the project's Building Information Model (BIM) as part of the input along with resource data. Then the process continues with optimization of all developed construction schedules according to the two mentioned objectives along with the introduced job-site movement objective, which mathematically helps the sequence of installation be more logical and practical. Finally generation of a 3D space for all the created and calculated construction schedules in the form of a 3D solution cloud point. These 3D construction schedules show solution cloud points and three Pareto Fronts for the given project.
Paired Comparisons as Applied to Seeding Cropland to Grass

F ARMERS are frequently asked by economists to explain or give reasons for their actions. A common approach is to simply ask farmers why they took some particular action. The reason most frequently given is ranked first, and so on. This method lacks precision. Another approach is "rank order" wherein each respondent is asked to rank a set of reasons presented to him. Appropriate weightings are established and the rank order is based on the sums of the weighting of each reason by all respondents.
$delta$ PRODUCTION VIA $gamma$p $Yields$ $delta$$pi$ BY LINEARLY POLARIZED PHOTONS AT 2.8 AND 4.7 GeV.

The production of $\ensuremath{\Delta}(1236)$ by linearly polarized photons at 2.8 and 4.7 GeV was studied using a hydrogen bubble chamber. At 2.8 GeV the cross sections for $\ensuremath{\gamma}p\ensuremath{\rightarrow}{\ensuremath{\Delta}}^{++}{\ensuremath{\pi}}^{\ensuremath{-}}(\ensuremath{\gamma}p\ensuremath{\rightarrow}{\ensuremath{\Delta}}^{0}{\ensuremath{\pi}}^{+},{\ensuremath{\Delta}}^{0}\ensuremath{\rightarrow}p{\ensuremath{\pi}}^{\ensuremath{-}})$ were found to be 3.7 \ifmmode\pm\else\textpm\fi{} 0.4 \ensuremath{\mu}b (0.5 \ifmmode\pm\else\textpm\fi{} 0.2 \ensuremath{\mu}b); at 4.7 GeV, 1.0 \ifmmode\pm\else\textpm\fi{} 0.1 \ensuremath{\mu}b (0.16 \ifmmode\pm\else\textpm\fi{} 0.09 \ensuremath{\mu}b). Measurement of the parity asymmetry, ${P}_{\ensuremath{\sigma}}$, for ${\ensuremath{\Delta}}^{++}$ production with $|t|l0.5$ Ge${\mathrm{V}}^{2}$ yielded the values -0.27 \ifmmode\pm\else\textpm\fi{} 0.12 and -0.53 \ifmmode\pm\else\textpm\fi{} 0.15 at 2.8 and 4.7 GeV, respectively, whereas pure one-pion exchange would lead to ${P}_{\ensuremath{\sigma}}=\ensuremath{-}1$.
Tachinid Flies Captured in Traps for Apple Maggot

A variety of traps with attractive odors have been used to capture adult apple maggots, Rhagoletis pomonella (Walsh), (Howitt and Conner 1965, Neilson 1960, and Still 1960). However, the beneficial Tachinidae that are parasitic on some orchard pest insects and others are often attracted to these traps (Moore 1969). Therefore, when traps were hung in apple trees at 10 locations (1 trap/tree) on Washington Island, Wis., and used to monitor adult populations of the apple maggot, the collections were also checked for captures of other Diptera. The trap was a modified double-wing trap developed by Howell (1972) for use against the codling moth, Laspeyresia pomonella (L.) that is commercially available (Pherotrap IC®). The bait, (ca. 15 ml) Maggottract™ I Bait, was exposed on cotton wicks placed inside a plastic vial.
Congenital cytomegalovirus disease: a NOW problem.

It is time that we begin to deal with congenital cytomegalovirus (CMV) disease as an infectious disease problem! Eighteen years have elapsed since the publication of Dr. Weller's classic articles alerting us to congenital CMV infection as a major public health problem in the United States [1,2]. Since that time, each year approximately 3000-4000 infants have been born with symptomatic disease; many of these infants have died, and almost all of the surviving children are severely damaged (mentally retarded, blind, or deaf). An additional 30 000-40 000 each year have been asymptomatic at birth, but MS^o (4500-6000) of these children have significant handicaps, such as deafness and neurological problems. In other words, in the last 18 y, 30 000-40 000 children have died or have required custodial care and major medical management for congenital CMV disease, and an additional 45 000-60 000 are deaf or have neurological problems [3-8]. During the last two decades, major strides have been made in understanding the natural history of CMV infection and disease in mothers and their infants. Also, the modes of transmission have been clearly defined [9-11]. Despite this accumulation of knowledge, however, we lack aggressiveness in dealing with this disease problem. There are at least five major areas in which we need to take more initiative: establishment of a surveillance system, education of physicians and parents regarding the problem and the means of prevention currently available, development of a suitable vaccine, detection of infected infants at birth, and initiation of clinical trials of antiviral agents.
Electrochemical lithiation of graphene-supported silicon and germanium for rechargeable batteries

Binder-free graphene-supported Ge nanowires, Si nanowires, and Si nanocrystals were studied for use as negative electrode materials in rechargeable lithium ion batteries (LIBs). Graphene obtained from reduced graphene oxide (RGO) helped stabilize electrochemical cycling of all of the nanomaterials. However, differential capacity plots revealed competition between RGO and Si/Ge lithiation. At high Si/Ge loading (>50% w/w) and low cycle rates ( C/10), RGO lithiation begins to dominate. Under those conditions, only Ge nanowires exhibited significant lithiation relative to RGO, most likely due to the inherently faster lithiation of Ge compared to Si.
BENZO-RING DIOL EPOXIDES OF BENZO(E)PYRENE AND TRIPHENYLENE

Polyole und Epoxide (I)-(VIII) von Benzo(e)pyren und Triphenylen werden nach bekannten Verfahren hergestellt.
In memory of Dr. G. T. Stevens, Jr., professor and chair emeritus, University of Texas Arlington

On December 10, 2015, the Engineering Economy community and the Industrial Engineering profession lost a dear colleague, a devoted teacher, an accomplished scholar, and a highly regarded administra...
Antibody detection on doubt patients of measles and rubella in Shunyi,Beijing from 2005 to 2009

Objective:To understand the current situation of measles and rubella infection in Shunyi district of Beijing from 2006 to 2008,analysis the promble existence now and provide strategies for those prevention and control.Methods:Applied the enzyme-linked immunosorbent assay(ELISA) to detect the antibody of IgM.Results:During the years 2006-2009,positive rate of measles was 5.2/100,000.while the rubella was 2.7/100,000.The positive rate of floating people was 71.4%,which was higher than the native people.Conclusion:We should strengthen the administration of the floating people,and expand the range of routine immunization services,pay more intention to the detection of disease.
The Effects of Fructus Corni Polysaccharides on the Proliferation of Human Cervical Cancer Cells and Expressions of Survivin and Bcl-2

Objective To explore the inhibitory effect of fructus corni polysaccharides on human cervical cancer cells and expressions of Survivin and Bcl-2 in HeLa cells. Methods MTT assay was used to determine the cell proliferation. Flow cytometry and immunohistochemistry SP methods were used to detect the apoptosis and protein expressions of Survivin and Bcl-2 in HeLa cells. Results There was a significant inhibitory effect of fructus corni polysaccharides on the prolifera tion in HeLa cells. The inhibitory degree was correlated with different concentrations and different action times of fructus cor nipolysaccharides. The apoptosis rates of HeLa cells were 10.1%, 21.6% and 28.9% for fructus corni polysaccharides concen trations of 6.25 g/L, 12.5 g/L and 25 g/L. The expressions of Survivin and Bcl-2 in HeLa cells were significantly lower in fruc tus corni polysaccharides treatment group than those of control group. Conclusion Fructus corni polysaccharides showed significant inhibitory effects on the proliferation in HeLa cells, which also decreased Survivin and Bcl-2 expressions and in duced the cell apoptosis.
Groundwater Connectivity between Douglas Lake and Carp Creek Based on Fluorescein Dye Studies

ABSTRACT Sandy-gravelly deposits are highly permeable and allow groundwater to seep from one lake to another in glacial lake districts such as occur throughout much of Michigan. The springs that form the headwaters of Carp Creek were assumed to have their origins as groundwater seepage from Douglas Lake. A tracer test using a concentrated fluorescein dye solution was conducted during the summer of 2011 to confirm the velocity of groundwater flow from Douglas Lake to a series of springs in Carp Creek. Five springs were monitored from 28 June to 21 September 2011. Dilution of the dye by groundwater was nine orders of magnitude (g−L to ng−L) by the time it reached the springs. The fastest travel times of the dye were ≤ 10 days to all except one spring giving an average observed linear velocity of approximately 100 m d−1 to travel an average distance of 1036 m. Dye was not detectable in the springs after 19 August (day 53 of the experiment). Observed seepage velocities were faster than those predicted from Da...
Introducing Marketing Planning to a Professional Services Organization

This paper examines an attempt to introduce a marketing planning system into a consulting firm. Recent depressionary economic conditions (1981–1982) affected the growth of the organization and highlighted the lack of formal marketing planning and organized marketing activities. The resultant efforts to institute effective marketing planning and to integrate marketing activities into this professional services organization are discussed.
Quantum optics of near number states and squeezed states: a proposal and a comparison

Sub-Poissonian light was first observed more than two years ago.1 Until today all the sub-Poissonian lights that have been experimentally generated are of low intensity. Thus high-gain low-quantum-efficiency photomultiplier tubes are required for their detection. As a consequence, the measured Fano factor F of these lights is near unity, i.e., near the coherent state or the usual shot noise limit.
Prevention of granulocyte-colony stimulating factor (G-CSF) induced bone pain using double histamine blockade

Febrile neutropenia (FN) is an oncological emergency that may reduce patient survival due to chemotherapy dose delays or reductions. It is recommended that patients at risk for FN receive prophylaxis with granulocyte-colony stimulating factor (G-CSF). Bone pain is a common side effect through a mechanism not fully understood. It is thought to be due to histamine release from an inflammatory response. This was a retrospective cohort from January to November 2015. Oncology patients receiving an initial dose of G-CSFs rated their bone pain on a 0–10 scale prior to starting each cycle of chemotherapy and at least 1 day after G-CSF had been given. Those who developed bone pain received prophylaxis at their next G-CSF dose with a combination of famotidine and loratadine. The primary endpoint was to determine the analgesic effects of double histamine blockade for G-CSF induced bone pain. The secondary endpoint was to determine potential risk factors for the development of bone pain. Thirty percent of patients developed bone pain within this cohort, and 17 patients were included in the final analysis. Bone pain scores were lower by a mean of 1.21[(0.20–2.23), p = 0.019] in patients who were prophylaxed with the double histamine blockade. Type of cancer, treatment, age, and BMI were not significant predictors of bone pain. The use of a double histamine blockade is an inexpensive, safe, and effective way to alleviate bone pain symptoms secondary to G-CSF agents. Further investigation is warranted for prospective larger studies to confirm these results.
Diagnosis and clinical management of embryonic mosaicism

Embryonic mosaicism occurs when two or more cell populations with different genotypes are present within the same embryo. New diagnostic techniques for preimplantation genetic screening (PGS), such as next-generation sequencing, have led to increased reporting of mosaicism. The interpretation of mosaicism is complicated because the transfer of some mosaic embryos has resulted in live births. Mosaic embryos may represent a third category between normal (euploidy) and abnormal (aneuploidy). This category of mosaic embryos may be characterized by decreased implantation and pregnancy potential as well as increased risk of genetic abnormalities and adverse pregnancy outcomes. Euploid embryos should be preferentially transferred over mosaic embryos. Genetic counseling is necessary before the transfer of a mosaic embryo is considered. Certain types of mosaic embryos should be preferentially transferred over others. Transfer of embryos with mosaic trisomies 2, 7, 13, 14, 15, 16, 18, and 21 may pose the most risk of having a child affected with a trisomy syndrome; however, the transfer of embryos with mosaic monosomies or other mosaic trisomies are not devoid of risk. Patients must be counseled about the risk of undetected monosomies or trisomies within a biopsy specimen as well as the risk of intrauterine fetal demise or uniparental disomy with the transfer of mosaic embryos. Until more data are available, patients should be encouraged to undergo another cycle to obtain euploid embryos, when possible, rather than transferring a mosaic embryo.
Yield and yield components of Arachis hypogaea L. as influenced by NPK chemical fertilizers, farm yard manure and gypsum

Field trials were conducted to evaluate the effect of chemical fertilizers, farmyard manure (FYM) and gypsum on yield and yield components of groundnut ( Arachis hypogea L.). There were nine treatments included unfertilized treatment and full doses of recommended NPK fertilizers (65:100:75 kg/ha) or reduced doses of recommended NPK fertilizers (30:50:37.5 kg/ha) and FYM@10 t/ha in combination with different levels (0, 150, 300 and 450 kg/ha) of gypsum. The results exhibited that full dose of NPK fertilizers with 300 kg/ha gypsum treatment gave significantly (P<0.05) higher seed yield (2777.28 kg/ha) than the full dose of NPK fertilizers alone (typical control) which had 2276.05 kg/ha. On the other hand, application of reduced dose of NPK fertilizers + 10 t/ha FYM with 450 kg/ha gypsum resulted 2609.88 kg/ha seed yield followed by 300 kg/ha gypsum application which had 2521.98 kg/ha and both values were statistically similar. Thus, use of 300 kg/ha gypsum could give high seed yield of groundnut with full dose of NPK fertilizers alone or reduced dose of NPK fertilizers and 10 t/ha FYM. However, combined application of organic and inorganic fertilizers is better practice especially on sandy regosol when considering human and soil health. Bangladesh J. Sci. Ind. Res. 51(4) , 285-290, 2016
Evaluating and optimizing the NERSC workload on Knights Landing

NERSC has partnered with 20 representative application teams to evaluate performance on the Xeon-Phi Knights Landing architecture and develop an application-optimization strategy for the greater NERSC workload on the recently installed Cori system. In this article, we present early case studies and summarized results from a subset of the 20 applications highlighting the impact of important architecture differences between the Xeon-Phi and traditional Xeon processors. We summarize the status of the applications and describe the greater optimization strategy that has formed.
Locating data use in the microprocesses of district-level deliberations

ABSTRACTWhile there is an abundance of data-use literature available, there is still a need to develop methodological approaches for studying naturally occurring data use in decision-making processes over time. The central contribution of this paper is a strategy to understand the use of data in long-term observations of educational leaders’ policy-making deliberations. Using longitudinal and observational data, we created ‘decision trajectories’ that traced microprocesses of deliberation around specific decisions over time. We employed frame theory to locate when and how data entered decision-making processes within these trajectories. Our approach addresses the use of data as they arise in the context of longitudinal observations – a method that provides insight into how data may be used to inform, frame, or justify educational decisions.
Update on Autoinflammatory Syndromes

Advances in genetic techniques have led to the discovery of new autoinflammatory syndromes in the last three years. The purpose of this review is to discuss novel autoinflammatory syndromes including disease mechanisms, characteristics, and treatments. We will also discuss recent findings regarding the pathophysiology of well-known autoinflammatory disorders. Several recently described autoinflammatory disorders will be discussed including NLRC4-MAS, NAIAD, CANDLE, SAVI, ORAS, HA20, DADA2, and APLAID. There is now a better understanding of the pathophysiology of autoinflammatory disorders that has allowed for categorization of these disorders into interferonopathies, inflammasome mediated, or NF-κB dysregulated. With a better understanding of these disorders, targeted treatments based on their mechanism are now possible. Some of these disorders have an unknown mechanism of action, and novel disorders are likely. Further research on autoinflammatory disorders is necessary to improve the outcomes of these patients.
Gamma-ray intensities in multi-gated spectra

Abstract The level structure of nuclei offers a large amount and variety of information to improve our knowledge of the strong interaction and of mesoscopic quantum systems. Gamma-ray spectroscopy is a powerful tool to perform such studies: modern gamma-ray multi-detectors present increasing performances in terms of sensitivity and efficiency, allowing to extend ever more our ability to observe and characterize abundant nuclear states. For instance, the high-spin part of level schemes often reflects intriguing nuclear shape phenomena: this behavior is unveiled by high-fold experimental data analyzed through multi-coincidence spectra, in which long deexcitation cascades become observable. Determining the intensity of newly discovered transitions is important to characterize the nuclear structure and formation mechanism of the corresponding levels. However, it is not trivial to relate the apparent intensity observed in multi-gated spectra to the actual transition intensity. In this work, we introduce the basis of a formalism affiliated with graph theory: we have obtained analytic expressions from which data-analysis methods can eventually be derived to recover this link in a rigorous way.
House of Netflix: Streaming media and digital lore

ABSTRACTThis article focuses on the emergence of a nascent streaming industry. The media industry studies conceptualization of “industry lore” can be read during times of transition for media indus...
Comparison of flowsheets for THF/water separation using pressure-swing distillation

Abstract An eloquent optimization method was recently proposed and tested on the separation of tetrahydrofuran and water using pressure-swing distillation. The purpose of this paper is to compare the results of this rigorous optimum design with the design presented in a 1985 paper, which used heuristic engineering optimization. The new design uses more feed preheating in the low-pressure column and a higher pressure with more trays in the high-pressure column. Simulation results show that the old design has a 14% lower energy cost.
A Framework for Personal Web Usage Mining.

In this paper, we propose to mine Web usage data on client side, or personal Web usage mining, as a complement to the server side Web usage mining. By mining client side Web usage data, more complete knowledge about Web usage can be obtained. A framework for personal Web usage mining is proposed. Some related issues and applications of personal Web usage mining
Review of Jesus

This new psychobiographical analysis of Jesus by Donald Capps promises to be a controversial but important book. While the venture is an engaging one, new theses about what and why Jesus did what he did suffer the same sorts of challenges as have traditional and critical presentations of the historical Jesus. This review engages theological issues and their implications, historical judgments and their plausibility, and methodological approaches and their fruitfulness.
A Criminological Fly in the Ointment: Specialty Courts and the Generality of Deviance

Specialty courts—such as drug courts, mental health courts, or domestic violence courts—tend to assume, either implicitly or explicitly, that particular groups of offenders have unique problems tha...
Partitioning of time trends in prevalence and mortality of lung cancer.

Background Time trends of lung cancer prevalence and mortality are the result of three competing processes: changes in the incidence rate, stage-specific survival, and ascertainment at early stages. Improvements in these measures act concordantly to improve disease-related mortality, but push the prevalence rate in opposite directions making a qualitative interpretation difficult. The goal of this paper is to evaluate the relative contributions of these components to changes in lung cancer prevalence and mortality. Methods Partitioning of prevalence and mortality trends into their components using SEER data for 1973-2013. Results The prevalence of lung cancer increases for females and decreases for males. In 1998, the former was due to increased incidence (45%-50% of total trend), improved survival (40%-45%), and increased ascertainment at early stages (10%-15%). In males, a rapidly declining incidence rate overpowered the effects of survival and ascertainment resulting in an overall decrease in prevalence over time. Trends in lung cancer mortality are determined by incidence during 1993-2002 with noticeable contribution of survival after 2002. Conclusion Lung cancer incidence was the main driving force behind trends in prevalence and mortality. Improved survival played essential role from 2000 onwards. Trends in stage ascertainment played a small but adverse role. Our results suggest that further improvement in lung cancer mortality can be achieved through advances in early stage ascertainment, especially for males, and that in spite of success in treatment, adenocarcinoma continues to exhibit adverse trends (especially in female incidence) and its role among other histology-specific lung cancers will increase in the near future.
Decreasing BMI/weight immediately prior to starting anti-PD-1/PDL-1 monoclonal antibodies for treatment for stage IV non-small cell lung cancer is associated with shorter progression-free survival.

e20710Background: Currently, prognostic markers associated with immunotherapy treatment outcomes in patients with metastatic NSCLC include PDL-1 expression, tumor mutational burden (TBM), and neutr...
“Fake news,” misinformation, and political bias: Teaching news literacy in the 21st century

In an era where claims of “fake news” abound and more people turn to social media for their daily updates, knowing how to find and critically appraise information is more important than ever. The w...
Dynamics reconstruction and classification via Koopman features

Knowledge discovery and information extraction of large and complex datasets has attracted great attention in wide-ranging areas from statistics and biology to medicine. Tools from machine learning, data mining, and neurocomputing have been extensively explored and utilized to accomplish such compelling data analytics tasks. However, for time-series data presenting active dynamic characteristics, many of the state-of-the-art techniques may not perform well in capturing the inherited temporal structures in these data. In this paper, integrating the Koopman operator and linear dynamical systems theory with support vector machines, we develop a novel dynamic data mining framework to construct low-dimensional linear models that approximate the nonlinear flow of high-dimensional time-series data generated by unknown nonlinear dynamical systems. This framework then immediately enables pattern recognition, e.g., classification, of complex time-series data to distinguish their dynamic behaviors by using the trajectories generated by the reduced linear systems. Moreover, we demonstrate the applicability and efficiency of this framework through the problems of time-series classification in bioinformatics and healthcare, including cognitive classification and seizure detection with fMRI and EEG data, respectively. The developed Koopman dynamic learning framework then lays a solid foundation for effective dynamic data mining and promises a mathematically justified method for extracting the dynamics and significant temporal structures of nonlinear dynamical systems.
openDIEL: A Parallel Workflow Engine and Data Analytics Framework

openDIEL is a workflow engine that aims to give researchers and users of HPC an efficient way to coordinate, organize, and interconnect many disparate modules of computation in order to effectively utilize and allocate HPC resources [13]. A GUI has been developed to aid in creating workflows, and allows for the specification of data science jobs, including specification neural network architectures, data processing, and hyperparameter tuning. Existing machine learning tools can be readily used in the openDIEL, allowing for easy experimentation with various models and approaches.
Identifying Sex of Neonate Turtles with Temperature-dependent Sex Determination via Small Blood Samples.

Temperature-dependent sex determination, present in most turtle species, is a mechanism that uses temperature to direct the sex of the embryo. The rapid increase of global temperatures highlights the need for a clear assessment of how sex ratios of organisms with TSD are affected. In turtles with TSD, quantifying primary sex ratios is challenging because they lack external dimorphism and heteromorphic sex chromosomes. Here we describe a new technique used to identify sex in neonate turtles of two TSD species, a freshwater turtle (Trachemys scripta) and a marine turtle (Caretta caretta) via analysis of small blood samples. We used an immunoassay approach to test samples for the presence of several proteins known to play an important role in sex differentiation. Our results show that Anti-Mullerian Hormone (AMH) can be reliably detected in blood samples from neonate male turtles but not females and can be used as a sex-specific marker. Verification of sex via histology or laparoscopy revealed that this method was 100% reliable for identifying sex in both T. scripta and C. caretta 1–2 day-old hatchlings and 90% reliable for identifying sex in 83–177 day-old (120–160 g) loggerhead juveniles. The method described here is minimally invasive, and for the first time, greatly enhances our ability to measure neonate turtle sex ratios at population levels across nesting sites worldwide, a crucial step in assessing the impact of climate change on imperiled turtle species.
13 – COSTS AND THE SUPPLY OF GOODS

Publisher Summary This chapter describes the link between costs and market supply. The nature and function of costs are central to economic analysis. The economist's measurement of costs sometimes differs from that of business decision makers and accountants. If the cost of producing a good exceeds its price, producers will not continue to supply it. Most persons recognize that supply and cost of production are closely linked. The chapter discusses the function of costs in a market economy. In a market economy, consumer demand and cost of production are central to the performance of this balancing function. The desire of consumers for a specific good must be balanced against the desire for other goods that could be produced with the resources. As resources have alternative uses, certain goods that could be produced with these resources must be foregone. It is these foregone opportunities that give rise to costs of production. Resources employed in the production of goods pay an amount that draw them away from their alternative employment opportunities. As resources are bid away from their alternative employment opportunities, costs of production are incurred. Costs of production reveal the value of the resources in their alternative uses.
El paraíso perdido: La adaptación a la pantalla de Las viudas de los jueves

In 2005, Claudia Pineiro published Las viudas de los jueves , a novel about the life in “countries” (gated neighborhoods) in the greater Buenos Aires, and in 2009, Marcelo Pineyro adapted it to the screen. Athough Mavi, a real estate agent, describes life there as a paradise, we see that problems and hypocrisy dominate throughout the film. Pineyro utilizes various cinematographic techniques to underscore the economic dichotomy between the “inside” and the “outside” and to emphasize the themes of sex and death. Dudley Andrew emphasizes the importance of “the sociology and aesthetics of adaptation,” and Pineyro’s film, just like the original novel, reflects what sociological studies by Svampa and Castelo reveal about life in the “countries.” In addition, the film is made in a moment in which Argentina’s economic problems continue. Although Pineiro’s work is not a detective novel, the structure of the two texts have elements in common with that genre. Although the film version does not have the moral weight of the original narrative, the film makes us see that life in the “countries” can be paradise lost.
A review of the effectiveness of hibiscus for treatment of metabolic syndrome

Abstract Ethnopharmacological relevance Hibiscus species (Family: Malvaceae) have long been used in traditional medicine to treat a variety of maladies such as abscesses, bilious conditions, cancer, cough, fatigue, gastrointestinal discomfort, fever, veisalgia, cardiovascular disorders, neurosis, scurvy, and urinary tract disorders. Its antioxidants have the capacity to destroy free radicals that damage cells and increase risk of inflammatory conditions such as metabolic syndrome, cancer, and cardiovascular disease. Aim of the study This review synthesizes findings from animal studies and clinical trials to assess effectiveness of hibiscus for treating biomarkers of metabolic syndrome including hyperglycemia, hypertriglyceridemia, low high-density lipoprotein, obesity, and hypertension. Materials and methods We searched for 12 edible species of hibiscus in the Google Scholar database. Each scientific name of these species, their common names and their edible plant parts were searched in conjunction with fourteen key words associated with metabolic syndrome. A total of 68 articles met all inclusion criteria for this review, including 18 that tested human subjects, 48 that tested other animals, one that tested humans and other animals, and one that did not specify. Results Hibiscus often improved blood glucose, total cholesterol, high-density lipoprotein cholesterol, triglycerides, blood pressure, weight, lipid absorption and oxidation of fatty acids within vital organs around the abdominal cavity. Higher doses led to greater benefits in some cases, especially for body mass of animals, but lower doses were often equally effective. Hibiscus was often equally or more effective than pharmaceuticals in improving some biomarkers of metabolic syndrome, especially blood glucose and insulin sensitivity. Conclusion Hibiscus shows great promise for improving biomarkers of metabolic syndrome, but there are limitations that need to be addressed by future work, including increasing the number and size of human clinical trials, expanding human trials to include people from a greater diversity of ethnicities, taking into account the health and physical activity of human participants, investigating the influence of growing conditions and extraction/preparation techniques on nutrients in hibiscus, comparing the efficacy of several plant parts and plant products of hibiscus to a reference control group within the same experiment, incorporating rigorous statistical analysis of treatments and investigating the influence of dosage.