cssi/SciSciGPT-SciSciNet huggingface dataset:
The genomic CDS sandbox

Display Omitted There is a need to promote development of resources for genomic CDS.The proposed sandbox will be available pre-configured with CDS and genome tools.We present survey results to assess needs for a genomic CDS sandbox.Results show strong interest for a sandbox to test CDS and genome case studies.Use of genomic CDS sandbox will enhance genomically-guided medicine. Genomics is a promising tool that is becoming more widely available to improve the care and treatment of individuals. While there is much assertion, genomics will most certainly require the use of clinical decision support (CDS) to be fully realized in the routine clinical setting. The National Human Genome Research Institute (NHGRI) of the National Institutes of Health recently convened an in-person, multi-day meeting on this topic. It was widely recognized that there is a need to promote the innovation and development of resources for genomic CDS such as a CDS sandbox. The purpose of this study was to evaluate a proposed approach for such a genomic CDS sandbox among domain experts and potential users. Survey results indicate a significant interest and desire for a genomic CDS sandbox environment among domain experts. These results will be used to guide the development of a genomic CDS sandbox.
Review: Haeckel's Embryos: Images, Evolution, and Fraud, by Nick Hopwood

Haeckel's Embryos: Images, Evolution, and Fraud . By Nick Hopwood. 2015. University of Chicago Press. (ISBN 978-0-226-04694-5). 388 pp. Hardcover. $45.00. Flip through biology textbooks, old or new, and chances are that you will find an illustration of vertebrate embryos arranged in rows and columns (see cover). This particular image, an embryo grid, is traced back to the work of Ernst Haeckel (1834–1919) and remains the single most published illustration in biology texts; no other diagram has proved so prevalent and resilient. Nick Hopwood's Haeckel's Embryos: Images, Evolution, and Fraud takes us on a journey of rich historical insight surrounding the origin and evolution of Haeckel's embryo grid. Hopwood is a professor at the University of Cambridge, where he studies embryonic development, the history of biology, and the visual culture of science. Having written a variety of scholarly articles about the history of embryology, Hopwood is no stranger to Haeckel's intriguing story, and Haeckel's Embryos presents a culmination (but not simply a repeat) of his previous publications. Hopwood provides the context for us to understand how Haeckel designed his drawings to mediate between a general …
Columnar Storage in SQL Server 2012

SQL Server 2012 introduces a new index type called a column store index and new query operators that efficiently process batches of rows at a time. These two features together greatly improve the performance of typical data warehouse queries, in some cases by two orders of magnitude. This paper outlines the design of column store indexes and batch-mode processing and summarizes the key benefits this technology provides to customers. It also highlights some early customer experiences and feedback and briefly discusses future enhancements for column store indexes.
Chemical Analysis of the Scent Fluid of Leptoglossus clypeatus

In central Texas the preferred natural habitat of the coreid bug Leptoglossus clypeatus (Heideman) is the common yucca, Yucca rupicola (Scheele), the waxy white blossoms of which offer food and lodging for this wary insect from late April to early June. After the petals have fallen from the plant the bugs can be found until late October on cultivated arborvitae, Thuja orientalis (L.).
Hesiod's Titans

In the opening lines of the Eumenides Aeschylus' Pythia says that the first prophetic deity at Delphi was Gaia. She was followed by two of her daughters in succession, Themis and Phoibe. Phoibe gave the oracle to Phoibos as a birthday present, and it is from her that he had his name.
TRANSFORMATION OF RANDOM BREAKING WAVES ON SURF BEAT

Based on a previous study by the authors of regular breaking waves in the surf zone, a model for random wave transformation across the nearshore region is developed. The results of a laboratory investigation of the effect of a steady opposing current on the wave decay process are presented and a proposed governing equation verified. Surf beat effects on wave transformation are then included in the model by representing the long wave as a temporally and spatiallyvarying current and mean water level. The concept of an equivalent water depth, which contains the effect of the current, is introduced and then included in a stochastic form in the random wave model. Surf beat is found to noticeably increase the decay of the root mean square wave height, especially in the inner surf where the beat is strongest. Comparison of the models to two field data sets show very good agreement for Hotta and Mizuguchi (1980), but rather poor for Thornton and Guza (1983). Possible explanations for the unexpected behavior of the second data set, pertaining to filtering, are discussed. Finally, a possible explanation for the dependence of random wave decay on deepwater steepness, noted by Battjes and Stive (1985), is presented.
A Study of the Wake Characteristics for Membrane Flat and Cambered Plates

This paper presents wake measurements behind thin plates with extensible membranes in low-Re flow (Re = 45,000). Many micro air vehicle designs, including fixedand flappingwing configurations utilize passive membrane flexibility to improve flight performance. At higher angles-of-attack compared to a rigid wing, the membrane extension (static or dynamic) due to aerodynamic loading modifies the development of the leading-edge shear layer and corresponding wake structure. Both flat and cambered plates with membrane surfaces and rounded leading-edges were studied. The aluminum plate wings were designed with a repeating membrane cell pattern and a high aspect ratio (AR = 8) to isolate leadingedge separation effects from pronounced tip vortex effects existing on low AR wings. Two basic wing designs were studied: batten reinforced membrane cells (free trailing-edge) and perimeter reinforced membrane cells (fixed trailing-edge). Wake width, momentum deficit and spectral energy results from hot-wire anemometry surveys are presented and discussed. The most dramatic effect on the wake structure, showing lower profile drag and well-defined spectral peaks, was a 20% scalloped version of the flat and cambered batten-reinforced plates.
Cytomegalovirus Infection in Pediatric Hematopoietic Stem Cell Transplantation: Risk Factors for Primary Infection and Cases of Recurrent and Late Infection at a Single Center

Cytomegalovirus (CMV) infection is a significant source of morbidity and mortality in allogeneic stem cell transplantation (SCT). We identified a cohort of 91 pediatric SCT patients at risk (defined as either donor and/or recipient seropositivity) for CMV infection at our institution. We retrospectively categorized at-risk SCT recipients as those who (1) were at risk of CMV infection in the post-SCT period, (2) had documented CMV infection before SCT, (3) experienced recurrence of post-SCT CMV viremia, or (4) experienced late post-SCT CMV viremia; categories were not mutually exclusive. We analyzed the impact of SCT-related factors on incidence of CMV infection and outcome, and we described the outcome of each of these cohorts. In univariate analysis, recipient CMV seropositivity, use of umbilical cord blood graft, and acute graft-versus-host disease (GVHD) predicted post-SCT CMV viremia, and the effects of acute GVHD (odds ratio, 4.018; 95% confidence interval, 1.032 to 15.643) and CMV seropositivity (odds ratio, 16.525; 95% confidence interval, 2.041 to 133.803) were confirmed in multivariate analysis. Patients with recurrence of post-SCT CMV viremia had a 50% all-cause mortality rate, compared with 12% in all 91 patients. Patients with pre-SCT CMV infection had a high incidence of post-SCT CMV infection but could successfully undergo SCT with antiviral prophylaxis and pre-emptive CMV treatment. All patients with late CMV infection had prior GVHD. Theses findings identify risk factors for post-SCT CMV infection and provide novel descriptions of childhood SCT recipients with pre-SCT, recurrent, and late CMV infection, which may contribute to risk stratification strategies for CMV at-risk patients in pediatric allogeneic SCT.
Ultrasonographic and morphological sequelae to repeated testicular biopsies in stallions in relation to the lateral branching of the testicular artery

Summary The objectives of this study were to investigate the sequelae to repeated testicular biopsies in stallions and to determine if arterial injuries can be prevented. This study was part of a larger project focused on the antispermatogenic effects of an oral contraceptive compound, RTI-4587-073(l), which was given to 3 mature Miniature horse stallions, while another 3 received a placebo treatment. Testicular biopsies were taken once before treatment and 3 times after treatment. They were obtained from alternating testes, 2 procedures per testis, 2 samples each time, using a 18 gauge split-needle core biopsy instrument (penetration depth: 22 mm). Colour Doppler ultrasonography was performed prior to the procedure to detect and thus avoid lateral branches of the testicular artery. Testicular parenchyma was evaluated ultrasonographically just before, and 2–6 h, 3 days and weekly after the biopsies were obtained. Changes in testicular volumes and semen parameters were monitored. All stallions were then castrated and the testes were evaluated for any gross pathology. There was no major scrotal swelling or gross haemorrhage after the procedures. Only mild, focal lesions were found in the testicular parenchyma 3 and 7 days after taking the biopsies. Three lateral branches of the testicular arteries were punctured, but there was no evidence of significant bleeding or other complications associated with these injuries. We conclude that repeated testicular biopsies may be taken from stallions without causing major complications, regardless of a presence or absence of the lateral branches of the testicular artery. Furthermore, we conclude that using colour Doppler ultrasonography to detect the lateral branches of the testicular arteries is unreliable; however, puncturing these vessels during a biopsy procedure does not necessarily result in significant haemorrhage.
For the Living: Thomas Paine’s Generational Democracy

This article shows that Thomas Paine’s political theory defends what I call generational democracy. Paine takes human mortality as a starting point to flesh out a conception of democracy that affirms the agency of the living. Generational democracy empowers the living to act as constitutional authors. The self-ennobling dimension of constitutional authorship and democratic socialization ensures a people capable of improving constitutions in ways that enhance democratic agency. The strengthening of democratic agency is also central to Paine’s right to welfare, which redresses legacies of economic injustice by creating substantial equality between generations. Welfare rights enhance the agency of the living by providing for economic opportunity and by securing agency in the face of impending death. Generational democracy achieves intergenerational justice and care for the future precisely because it focuses on enhancing the democratic agency of the living generation.
OPTIMAL SEARCH DESIGNS, OR DESIGNS OPTIMAL UNDER BIAS FREE OPTIMALITY CRITERIA*

Publisher Summary This chapter discusses whether the usual optimal designs are really optimal, with the possibility of the underlying model may be biased. The theory of search models offers the possibility of searching the bias and correcting for the same. As the true model is rarely known and as it is far easier to postulate a family of models, one of which is the true model, the idea of search should be inherent in the statistical aspects of most scientific experimentation. Thus, the problem of optimal designs is more a problem of obtaining a design that would be good from the viewpoint of a whole family of models rather than of any single model inside this family. The chapter presents certain optimality criteria for designs, where optimality takes the above view point into account. It also presents search linear models needed for development. It highlights the concept of optimal search designs and the criteria of AD-optimality and DD-optimality.
A rural society after the Black Death: People, land and occupations

There are many ways to approach the study of an historical rural society. One of the most revealing is to begin by inspecting cross-sections of its economic composition, for doing so can lead to many insights into the nature of that society that are not necessarily obvious at the outset. In this respect the two most revealing indices that late-medieval Essex sources can provide are landholding profiles and occupational structures. The rural economy of northern and central Essex in the later middle ages was a mixture of farming, crafts or industry, and trading, and the basic unit of production in this economy was the household, with family labour inputs supplemented, at times heavily, with hired workers. And yet households differed widely in their endowments of land or other capital, and at least half of all the families in the district during the later fourteenth and fifteenth centuries derived much or most of their income from wages earned from others. Landholding and occupation were therefore intricately intertwined. Later sections of this study will observe that many demographic and other aspects of life in late-medieval Essex differed considerably between different occupational groups, so a first step towards understanding the significance of these experiences is to be quite precise about how the groups were configured. Within any traditional agrarian society the landholding profile – the distribution of landholdings of different sizes among its population – bears much influence upon the nature of social relationships and economic development.
Nonclassic Signaling in the Brain

This chapter outlines the different types of chemical communication, focusing on the way these signaling systems function in the brain. The nonclassic neurotransmitters share many of the same fundamental properties of the classic neurotransmitters. They are not always locally synthesized, some being derived from other tissues in the body or regions of the brain. Nor are they always stored to await a specific release signal; in some cases the signaling mechanism for release is the same as the stimulus for synthesis, and thus these messengers are released as quickly as they are synthesized. The biochemical aspects of chemically coded interneuronal transmission are discussed in the chapter. Neuroscience is multidisciplinary, requiring an appreciation of several different aspects of cellular function to come to grips with the basic principles of integrated neuronal function. Synaptic transmission is a dynamic process that is constantly changing; therefore, the study of synaptic transmission is also dynamic, requiring frequent reevaluation and revision.
Spotlight on empagliflozin/metformin fixed-dose combination for the treatment of type 2 diabetes: a systematic review

The dramatic rise in the prevalence of obesity and diabetes is associated with increased morbidity, mortality, and public health care costs worldwide. The need for new, effective, and long-lasting drugs is urgent. Recent research has focused on the role of the inhibitors of sodium- glucose co-transporter 2 (SGLT-2). Clinical trials have shown that SGLT-2 inhibitors have glycemic efficacy and weight-lowering potential. Dual drug therapy is a recommended therapy for patients with new-onset type 2 diabetes who need significant glycemic control. Fixed-dose combination therapy represents a particularly attractive option as it may reduce pill burden and improve adherence. The combination of metformin and empagliflozin was approved by the US Food and Drug Administration in 2014 and represents a safe and effective means to combat glycemic control and weight gain. The purpose of this systematic review is to summarize the background of the SGLT-2 inhibitors, particularly empagliflozin, and focus on the safety and efficacy of the fixed-dose combination of empagliflozin and metformin.
Genomic Aberrations in Multiple Myeloma.

Multiple myeloma (MM) is a genetically complex disease. The past few years have seen an evolution in cancer research with the emergence of next-generation sequencing (NGS), enabling high throughput sequencing of tumors—including whole exome, whole genome, RNA, and single-cell sequencing as well as genome-wide association study (GWAS). A few inherited variants have been described, counting for some cases of familial disease. Hierarchically, primary events in MM can be divided into hyperdiploid (HDR) and nonhyperdiploid subtypes. HRD tumors are characterized by trisomy of chromosomes 3, 5, 7, 9, 11, 15, 19, and/or 21. Non-HRD tumors harbor IGH translocations, mainly t(4;14), t(6;14), t(11;14), t(14;16), and t(14;20). Secondary events participate to the tumor progression and consist in secondary translocation involving MYC, copy number variations (CNV) and somatic mutations (such as mutations in KRAS, NRAS, BRAF, P53). Moreover, the dissection of clonal heterogeneity helps to understand the evolution of the disease. The following review provides a comprehensive review of the genomic landscape in MM.
Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 Endonuclease.

Purpose To employ type II clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 endonuclease to suppress ocular angiogenesis by genomic disruption of VEGF-A in human RPE cells.
Epilepsy, a Cyberattack on Brains’ Networked Control System

Understanding pathways of neurological disorders requires extensive research on both structural and functional characteristics of the brain. Graph theoretical analysis of functional connectivity networks highlight the dynamics of communication among brain neurons. Resembling brain to a Networked Control System, describes seizure, epileptic episodes, as a response to a set of triggers. This unknown set attempts to destabilize the system and so referred as cyberattacks in network terminology. The study investigates the dynamics of brain networks under the attack of epileptic seizures focusing on the network parameters variation for pre-inter-and post-attack durations. Statistical analysis of the Scalp EEG-based connectivity networks found significantly (p
Osteoporosis and the Female Athlete Triad

Over the past four decades, an increase in the number of girls and women participating in sports has led to growing concerns about a series of three interrelated disorders observed by those involved in caring for the health of this cohort. This group includes parents, coaches, athletic trainers, team physicians, and administrators at the high school and college level and, to a certain extent, at the level of professional sports. Broadly defined, the components are (1) energy availability (EA) from optimal energy availability to an end point of low energy availability with or without eating disorders; (2) menstrual function from amenorrhea (normal menses) to an end point of amenorrhea (delayed menses or cessation for a period of 3 months); and (3) bone mineral density (BMD) from optimal bone density to an end point of osteoporosis. Although this book focuses on osteoporosis, it is important to understand that each of these components has implications for the next. Energy deficiency associated with eating disorders has a causal role in the development of menstrual irregularities; both energy deficiency and the hypoestrogenic environment linked to amenorrhea affect BMD. In addition, recent research suggests that this hypoestrogenic state could lead to endothelial dysfunction, resulting in cardiovascular disease, an association that could turn the triad into a tetrad.
Failure to find a distance effect in pigeon choice

Primates take longer to choose between alternatives with smaller differences in value. This effect—a particular instance of the distance effect in symbolic comparisons—has not been replicated in birds. Instead, birds appear to respond independently to each alternative, such that the latency to choose depends primarily on the alternative of highest value. Three experiments tested for the distance effect in pigeons under conditions not previously considered. Experiment 1 presented pigeons with forced- and binary free-choice trials, where each alternative was one of three possible delays to reinforcement (4, 8, and 16 s). Pigeons were exposed to the choice stimuli for different amounts of time and with different sample response requirements prior to the choice response. Experiment 2 added a fourth (0-s delay) alternative. Experiment 3 substituted the 16-s delay with a second 4-s delay. In all experiments, pigeons systematically chose the shortest delay to reinforcement. Latency to choose the 4-s delay did not vary when choosing against the 8-s or 16-s delay, regardless of whether choice stimuli were exposed for the duration of nine pecks (Experiment 1), or whether a 0-s delay alternative was sometimes present (Experiment 2). Latency to choose the preferred of two identical alternatives (4-s vs. 4-s) was shorter than the latency to choose between different alternatives (4-s vs. 8-s; Experiment 3); this is the opposite of a distance effect. These results show no evidence of a distance effect in pigeon choice, consistent with the hypothesis that pigeons respond independently to each choice alternative.
Finite-element domain decomposition methods for analysis of large-scale electromagnetic problems

This paper presents an overview of our recent development of domain decomposition methods for finite element analysis of large-scale electromagnetic problems. More specifically, it presents several domain decomposition algorithms based on the Dual-Primal Finite Element Tearing Interconnecting (FETI-DP) method for solving vector wave equations. These algorithms expand the capability and improve the performance of the FETI-DP method by: (1) lifting the requirement of conformal meshes on subdomain interfaces, (2) speeding up the convergence of the iterative solution of the global interface problem, and (3) incorporating appropriate truncation boundaries for more accurate simulation. Numerical results are presented to demonstrate the application, accuracy, efficiency, and capability of these algorithms.
SUMOylation Regulates Transcription by the Progesterone Receptor A Isoform in a Target Gene Selective Manner

Luminal breast cancers express estrogen (ER) and progesterone (PR) receptors, and respond to endocrine therapies. However, some ER+PR+ tumors display intrinsic or acquired resistance, possibly related to PR. Two PR isoforms, PR-A and PR-B, regulate distinct gene subsets that may differentially influence tumor fate. A high PR-A:PR-B ratio is associated with poor prognosis and tamoxifen resistance. We speculate that excessive PR-A marks tumors that will relapse early. Here we address mechanisms by which PR-A regulate transcription, focusing on SUMOylation. We use receptor mutants and synthetic promoter/reporters to show that SUMOylation deficiency or the deSUMOylase SENP1 enhance transcription by PR-A, independent of the receptors' dimerization interface or DNA binding domain. De-SUMOylation exposes the agonist properties of the antiprogestin RU486. Thus, on synthetic promoters, SUMOylation functions as an independent brake on transcription by PR-A. What about PR-A SUMOylation of endogenous human breast cancer genes? To study these, we used gene expression profiling. Surprisingly, PR-A SUMOylation influences progestin target genes differentially, with some upregulated, others down-regulated, and others unaffected. Hormone-independent gene regulation is also PR-A SUMOylation dependent. Several SUMOylated genes were analyzed in clinical breast cancer database. In sum, we show that SUMOylation does not simply repress PR-A. Rather it regulates PR-A activity in a target selective manner including genes associated with poor prognosis, shortened survival, and metastasis.
Addressing Mental Health Needs for Deaf Patients Through an Integrated Health Care Model

Deaf individuals struggle with accessing mental health services because of language and cultural discordance. Our project's purpose was to design and pilot an accessible, integrated mental health program for the Deaf population, scalable for other health centers interested in serving these individuals. Our team addressed several identified barriers to care. The addition of a language-concordant mental health clinician and telemental health appointments helped us better manage Deaf patients' mental health needs. Individual and clinic level data were collected and analyzed. Results demonstrated a significant improvement in the patients' depression and anxiety scores from their baseline to their last documented visit. Patient satisfaction overall was high. Telemental health appears to be a feasible tool to address some of the mental health gaps in the Deaf community. Further studies are needed to demonstrate how this program can be effective within a larger geographical area.
Spine surgery for lumbar degenerative disease in elderly and osteoporotic patients.

Abstract Elderly patients with lumbar spine degenerative disease present significant challenges regarding surgical decision making and management. Because osteoporosis is a particularly prevalent comorbidity in the elderly population, it must be a concern in all elderly patients with degenerative disease of the lumbar spine. Careful attention to surgical indications and surgical technique is always required for the successful treatment of this challenging patient population.
Bodyweight Gain Induced by Psychotropic Drugs

Some bodyweight gain is common with many of the psychotropic drugs frequently used to treat psychiatric disorders. Although in most instances the gain is not clinically significant, that induced by some drugs, such as lithium and atypical antipsychotics, can be quite large and clinically significant. Individual patients may not wish to continue with medications that increase bodyweight, even by amounts that have no significant effect on health. The true prevalence of bodyweight gain is often difficult to discern because of confounding factors within studies that have assessed this effect, such as the simultaneous use of multiple drugs and the absence of data on starting bodyweight. Risk factors for weight increase have not yet been well characterised, although in general the potential for drug-induced bodyweight gain is greatest in individuals with a past and/or family history of obesity. Little is currently known about the mechanisms of bodyweight gain that is induced by any drug.
Pharmacokinetics of intravenous flumetasone and effects on plasma hydrocortisone concentrations and inflammatory mediators in the horse.

BACKGROUND Flumetasone is a potent corticosteroid reportedly used in horses to decrease inflammation associated with strenuous exercise. There are currently no reports describing the use of this drug in horses. OBJECTIVES To describe the pharmacokinetics and effects on cortisol and eicosanoid concentrations, following administration of flumetasone to exercised horses. STUDY DESIGN Parallel design. METHODS Twelve exercised horses received a single i.v. administration of 5 mg of flumetasone. Blood and urine samples were collected before and for 72 h post-drug administration for determination of flumetasone and cortisol concentrations. Whole blood samples were collected at various time and challenged with lipopolysaccharide, calcium ionophore or methanol to induce ex vivo synthesis of eicosanoids. Concentrations of flumetasone, cortisol and eicosanoids were measured using LC-MS/MS and pharmacokinetic/pharmacodynamic analysis performed. RESULTS Flumetasone was detected for 23.5 ± 1.73 h in blood. The volume of distribution at steady state, systemic clearance and elimination half-life was 5.90 ± 0.200 L/kg, 30.7 ± 0.166 mL/min/kg and 4.84 ± 0.83 h respectively. Cortisol concentrations were still suppressed at last time point collected (72 h). For cortisol, Kin , Kout and the t1/2out were 30.3 ± 1.56 ng/mL × h, 0.331 ± 0.02 1/h and 2.1 h respectively. Stimulation with lipopolysaccharide resulted in a decrease in TXB2 , PGF2 , LTB4 , 15-HETE and 5-HETE for up to 72 h and PGE2 for 24 h post-flumetasone administration. Stimulation of whole blood with calcium ionophore resulted in a decrease in LTB4 for up to 6 h and 15-HETE at 8 h. MAIN LIMITATIONS Lack of sample collection for determination of biomarker concentrations beyond 72 h and the use of a single sample for determination of baseline cortisol concentrations. CONCLUSIONS Flumetasone is rapidly cleared from blood following administration to horses. It is a potent anti-inflammatory with prolonged effects on production of cortisol and other inflammatory mediators.
Abstract B07: Targeting DAB2IP in ovarian cancer stem cells

Ovarian cancer is the leading cause of death from gynecologic malignancies. Failure to eliminate ovarian cancer stem cells (OCSCs) by the end of conventional chemotherapy contributes to tumor relapse and metastasis. Understanding the molecular features of OCSCs may allow for effective targeting and eradicating these cells and tumor remission. We reported tumor-initiation and expansion capacity by ALDH+ OCSCs after platinum-based treatment of ovarian cancer xenografts. In addition, loss of DAB2IP in prostate and colon cancer promoted CSC-like features, suggesting a critical role in modulating CSC maintenance. DAB2IP, a novel member of Ras GTPase-activating (GAP) protein family, was identified as a potent tumor suppressor that interfered with many aspects of cancer progression and was frequently downregulated in tumors. In the current study, we aimed to elucidate the tumor-suppressor role of DAB2IP in ovarian cancer in the context of OCSCs and explore epigenetic approaches to upregulate its expression. OCSCs and non-CSCs subpopulations were isolated from multiple high-grade serous ovarian cancer cell lines (Kuramochi, OVCAR3, and COV362). Reduced (p Citation Format: Xingyue Zong, Ali R. Ozes, Kenneth P. Nephew. Targeting DAB2IP in ovarian cancer stem cells. [abstract]. In: Proceedings of the AACR Conference: Addressing Critical Questions in Ovarian Cancer Research and Treatment; Oct 1-4, 2017; Pittsburgh, PA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(15_Suppl):Abstract nr B07.
Improving Child Health through Technology-Supported Active Transport: A Survey of Parent Perspectives

Urban and suburban communities around the world have experienced a significant decrease of children moving around independently relative to just a decade or two ago. Child independent mobility (CIM) refers to that freedom of children to be away from constant direct adult supervision as they move in their communities. CIM has a demonstrable positive impact on a child's physical, social, and emotional health, yet a considerable decline in its prevalence persists. This paper presents a survey of parents' attitudes, experiences, and behaviors related to their school-age children and their (independent) mobility. We posit that pervasive computing technology has the potential to play a role in bolstering CIM and therefore improving the health of children; to that end, the survey also investigates parent's attitudes, experiences, and behaviors relating to their child's use of pervasive computing technologies. Finally, the survey reports on parents responses to hypothetical technology-supported CIM scenarios, using these results to make recommendations related to research in technology-supported CIM.
Endothelial Activation and Stress Index (EASIX) at Admission Predicts Fluid Overload in Recipients of Allogeneic Stem Cell Transplantation.

ABSTRACT Fluid overload (FO) grade ≥2 (more than 10% weight gain from baseline) has recently been recognized as an important toxicity associated with a high rate of nonrelapse mortality in recipients of allogeneic hematopoietic cell transplantation (AHCT). The causes for FO remain unclear. We hypothesized that endothelial damage, possibly due to treatments received prior to AHCT, may be associated with this toxicity and sought to determine whether the Endothelial Activation and Stress Index (EASIX) (defined as lactate dehydrogenase [U/L] × creatinine [mg/dL]/platelets [109 cells/L]) correlates with grade ≥2 FO in 2 cohorts of recipients of AHCT at our institution. We tested our hypothesis in a cohort of 145 consecutive recipients (study cohort) of AHCT transplant from HLA-haploidentical donors and validated the findings in a cohort of 449 (validation cohort) recipients of AHCT from HLA-matched donors who underwent transplantation between 2010 and 2015. Predictors of grade ≥2 FO were evaluated using competing risks regression in univariate analysis and classification and regression tree (CART) analysis in multivariate analysis. The cumulative incidence of grade ≥2 FO was estimated considering death as a competing risk. EASIX scores were evaluated based on log2-transformed values. Optimal predictive EASIX cutoff values were determined based on receiver operating characteristics curve analysis. Grade ≥2 FO occurred in 21% and 6% of the study and validation cohorts, respectively, with the majority of these cases being diagnosed before the day of AHCT. Median log2 EASIX score at admission was 2.4 (interquartile range [IQR], 1.3, 3.7) and 2.5 (IQR, 1.4, 3.9) in the 2 respective cohorts. In univariate analysis, high EASIX at admission was a significant predictor of grade ≥2 FO in the study (cutoff: 4.4, hazard ratio [HR] = 4.8, P 60 years (HR = 9.6, P = .04) in the validation cohort. At admission, the prevalence of EASIX score of >4.3 (18% versus 17%, P = .9) was not different between the diabetics and nondiabetics. EASIX score at admission is a significant predictor of grade ≥2 FO in recipients of AHCT from HLA-haploidentical or HLA-matched donors. Independently of EASIX, older patients with low weight were associated with increased risk of grade ≥2 FO for recipients of HLA-haploidentical transplants. For the HLA-matched cohort, diabetes and older age were associated with increased FO risk. These findings require validation in external cohorts.
A redescription of deep-channel ghost knifefish, Sternarchogiton preto (Gymnotiformes: Apteronotidae), with assignment to a new genus

ABSTRACT From a study of morphological and molecular datasets we determine that a species originally described as Sternarchogiton preto does not form a monophyletic group with the other valid species of Sternarchogiton including the type species, S. nattereri. Previously-published phylogenetic analyses indicate that this species is sister to a diverse clade comprised of six described apteronotid genera. We therefore place it into a new genus diagnosed by the presence of three cranial fontanels, first and second infraorbital bones independent (not fused), the absence of an ascending process on the endopterygoid, and dark brown to black pigments over the body surface and fins membranes. We additionally provide a redescription of this enigmatic species with an emphasis on its osteology, and provide the first documentation of secondary sexual dimorphism in this species.
Chapter Twenty-Five – Sheet Methods

Publisher Summary Sheet methods—such as paper and thin-layer chromatography—are used to separate a wide variety of organic and inorganic mixtures. A sheet method is considered an open, thin column. This technique, in comparison to column techniques, has the advantages of being simple, rapid, and inexpensive. It also provides excellent resolving power. Although quantitative results are possible, the main application is in qualitative identification, because very small quantities of sample are easily handled. Sheet methods can also be scaled up to handle purification on a preparative basis. Because a sheet method is similar to a column method, adsorption, partition, sieving, and ion exchange are readily carried out on a sheet. Inorganic as well as organic mixtures are separated by sheet methods. The chapter also describes the experimental procedures, which include pretreatment, sample application, developing chambers, development, and visualization.
Temporomandibular Joint Dysfunction

Temporomandibular joint (TMJ) dysfunction is a chronic pain condition characterized by pain in the joint that can also radiate into surrounding anatomical structures such as the ear, mandible, or neck. The TMJ is a true joint that contains an upper and lower synovial cavity with an articular disk located between the two cavities. The pain associated with TMJ dysfunction is usually related to inflammation or instability of the intracapsular disk, but may also be related to the muscles surrounding the joint, including the temporalis, internal and external pterygoids, and the masseter. Other muscles that may be involved include the trapezius and sternocleidomastoid. TMJ dysfunction should be carefully distinguished from other possible etiologies of pain with similar facial patterns, such as giant cell arteritis, trigeminal neuralgia, otitis, and complex regional pain syndrome. Diagnostic work-up of TMJ dysfunction can involve imaging modalities such as dental X-rays, panoramic radiographs, CT, MRI, and scintigraphy, as well as more invasive options such as arthroscopy of the TMJ. Treatment for TMJ dysfunction starts with conservative therapies including patient education, physical therapy, behavior modification, and oral orthotic devices. Oral pharmacologic agents such as Ibuprofen, Cyclobenzaprine, Gabapentin, and Amitriptyline have also been shown to help relieve symptoms. If conservative management is not effective, intra-articular injection of the joint with a combination of local anesthetic and steroid can be performed. Other injections such as intra-articular hyaluronate and injection of botulinum toxin into the temporalis and masseter muscles have been studied. Surgeries are performed on the TMJ itself to correct structural etiologies of dysfunction and are considered if more conservative therapies are not effective.
Bioprosthetic valve oversizing is associated with increased risk of valve thrombosis following TAVR.

Background Hypoattenuating leaflet thickening (HALT), the radiographic manifestation of transcatheter heart valve thrombosis, is commonly identified following transcatheter aortic valve replacement (TAVR) and associated with increased risk of stroke and structural valve deterioration. While anticoagulation effectively resolves HALT, routine use remains controversial. We aimed to identify hemodynamic, anatomic, and comorbid predictors of HALT. Methods We evaluated consecutive patients with severe aortic stenosis who underwent TAVR with Edwards SAPIEN 3 bioprosthesis at a single center between June 1, 2018 and October 30, 2019. Patients on anticoagulation and those receiving valve-in-valve were excluded. Clinically driven computed tomography (CT) imaging was performed to assess for HALT at the discretion of the treating valve team. Results A total of 78 patients with a mean age of 78 ± 10 years and STS risk score 5.5 ± 3.3% were analyzed. HALT was identified in 11 (14.1%) patients. Compared to controls, those with HALT had smaller annular areas, 435 ± 57 mm2 vs. 489 ± 79 mm2 (p = .032), but received comparable size valves. In multivariate regression, valve oversizing by more than 20% was associated with increased risk of HALT, OR 23.5, 95% CI 2.5-223, (p = .006). After initiation of anticoagulation, patients with HALT had similar rates of stroke, major bleeding, and all-cause mortality out to an average of 243 days. Conclusions In this pragmatic study of patients undergoing TAVR with SAPIEN 3 valves, we report the novel finding that oversizing by more than 20% was independently associated with increased risk of HALT. These findings warrant confirmation in larger and prospective trials.
Single-stage repair for coarctation with ventricular septal defect: results of 100 cases at a single centre.

Objectives The outcomes of the single-stage surgical repair of aortic arch hypoplasia (AAH) and/or coarctation of the aorta (CoA) associated with ventricular septal defect (VSD) remain controversial, especially in a lower middle-income country. This study reports the results of a single-stage repair protocol at our institution for AAH/CoA with VSD using selective cerebral perfusion. Methods This retrospective study included 100 consecutive patients who underwent single-stage repair via median sternotomy using selective cerebral perfusion for AAH/CoA with VSD from July 2010 to March 2017. Results The patients consisted of 65 males and 35 females. The median age of the patients was 67 days (range 4-2266 days); the median weight was 3.8 kg (range 2.1-15 kg). The average cardiopulmonary bypass time was 132 ± 28 min, the aortic cross-clamp time was 92 ± 23 min and the selective cerebral perfusion time was 33 ± 10 min. The survival rate of all patients was 94.7 ± 2.3%, with an in-hospital mortality of 5% and no late mortality at a median follow-up of 37 months (range 4-96 months). Four patients required reoperation due to recoarctation. The overall event-free survival rate following surgery was 87.1%. The median pressure gradient across the anastomosis at the last follow-up was 8.3 ± 2.8 mmHg. Multivariate logistic regression analysis revealed proximal aortic arch obstruction as a predictor of mortality (odds ratio = 3.8). The aortic isthmus diameter was identified as a predictor for reintervention by Cox regression (hazard ratio = 6.7). Conclusions Single-stage repair for AAH/CoA with VSD is safe and feasible in a developing country.
Facebook's Faces

The Facebook Oversight Board’s decision about the suspension of Donald Trump’s account is different from the Board’s other cases because it interests states. The ‘Trump Ban’ case affects the Board’s reputation and Facebook’s relationships with states and publics. We will not understand the case’s impact if we do not understand these relationships. Scholarship about social media platforms discusses their relationship with states and users. The Essay is the first to expand this theorization to account for differences among states, the varying influence of different publics and the internal complexity of companies. Theorizing Facebook’s relationships this way includes less influential states and publics that are otherwise obscured. It reveals that Facebook engages with states and publics through multiple, parallel regulatory conversations, further complicated by the fact that Facebook itself is not a monolith. This Essay argues that Facebook has many faces – different teams working towards different goals, and engaging with different ministries, institutions, scholars and civil society organizations. Content moderation exists within this eco-system. This Essay’s account of Facebook’s faces and relationships shows that less influential publics can influence the company through strategic alliances with strong publics or powerful states. It also suggests that Facebook’s carelessness with a seemingly weak state or a group, may affect its relationship with a strong public or state that cares about the outcome. To be seen as independent and legitimate, the Oversight Board needs to show its willingness to curtail Facebook’s flexibility in its engagement with political leaders where there is a real risk of harm. This Essay hopes to show Facebook that the short-term retaliation from some states may be balanced out by the long-term reputational gains with powerful publics and powerful states who may appreciate its willingness to set profit-making goals aside to follow the Oversight Board’s recommendations.
Compliance With Preferred Reporting Items for Systematic Review and Meta-Analysis Individual Participant Data Statement for Meta-Analyses Published for Stroke Studies.

Background and Purpose: Individual-participant data meta-analyses (IPD-MA) are powerful evidence synthesis studies which are considered the gold-standard of MA. The quality of reporting in these st...
Evaluation of irrigation suitability potential of brewery effluent post treated in a pilot horizontal subsurface flow constructed wetland system: implications for sustainable urban agriculture.

Abstract The use of untreated or partially treated wastewater reuse for urban and peri-urban agricultural irrigation is a common practice in developing countries like Ethiopia. Such practices, however, pose significant environmental and public health risks. The objective of this study was to evaluate the irrigation suitability of anaerobic digestion brewery effluent (ADBE) and two-stage horizontal subsurface constructed wetland post-treated ADBE (CWPBE). A series of pot experiments were conducted in a plastic - greenhouse system arranged in three sets of irrigation schemes: Treatment Group1 (TG1): municipal pipe tap water (MPTW) irrigated pots; Treatment Group2 (TG2): ADBE irrigated pots, and Treatment Group3 (TG3): CWPBE irrigated pots. Pots packed with the same amount of sandy clay loam soil and local tomato seeds sown were irrigated following an updated tomato irrigation schedule derived from the FAO CROPWAT stimulation model for 120 days. The findings from key irrigation water quality parameters showed that the CWPBE achieved the prescribed irrigation water standards with values of pH (7.4 ± 0.15), electrical conductivity (1.9 ± 0.11 dS.m−1), total suspended solids (25 ± 4.17 mgL-1), chemical oxygen demand (185.1 ± 1.66 mgL-1), total nitrogen (17.4 ± 0.7 mgL-1), total phosphorous (8.8 ± 0.26 mgkg-1), calcium (10.5 ± 3.6 mgkg-1), magnesium (4.9 ± 0.98 mgkg-1), sodium (4.4 ± 1.51 mgkg-1), potassium (2.3 ± 1.15 mgkg-1), sodium adsorption ratio (1.6 ± 0.34), and total coliform (8 ± 0.16×10−5 CFU/100 mL). Moreover, tomato plants grown in TG3 attained higher growth such as number of leaves (85.6 ± 4.68), plant height (92.2 ± 1.29 cm), stem diameter (13.1 ± 2.35 cm) and leaf area (35.5 ± 1.03 cm2) as well as higher biomass (61.2 ± 1.33 kgm−2) and fruit (46.4 ± 3.51 kgm−2) yields over other treatment groups. The results revealed that irrigation waters significantly improved both growth and yield parameters of tomato plants with the ascending order of TG1
Comunicabilidad y mediatización de los discursos psicoanalíticos en Buenos Aires

En este articulo analizo la circulacion de discursos psicoanaliticos fuera de la clinica a traves de algunos de sus canales mediaticos mas cotidianos y masivos. Para ello utilizo el concepto de comunicabilidad (Briggs; Hallin 2007), que ilumina como se difunden los discursos a traves de ideologias desarrolladas historicamente, y de mediatizacion (Agha, 2011), que designa la amalgama que se forma entre procesos comunicativos y su mercantilizacion. El analisis se centra en tres medios: humor grafico, programas de televisiony anuncios publicitarios que circulan en la ciudad de Buenos Aires. Un argumento clave del analisis es que la escucha psicoanalitica juega un papel importante en la diseminacion y reproduccion en la esfera publica de discursos psicoanaliticos a traves de la recepcion y continuo reciclaje de estos discursos por parte del publico lego.
Novel Personal Corporate Structures, Fiduciary Responsibility, and the Ethics of Personhood

The book The Unincorporated Man envisions a future in which every individual is incorporated at birth, and their worth and value are determined on a market exchange. The book uncovers profound questions about personal autonomy and fiduciary responsibility in a world where personhood is commodified, and offers a unique lens into contemporary questions about work/life balance, the degrees of freedom each of us have, and the nature of competing obligations. It provides an interesting perspective into issues we wrestle with today. This paper considers the use of Personal Service Corporations and other contemporary legal vehicles from that perspective.