cssi/SciSciGPT-SciSciNet huggingface dataset:
Women's lived experience of infertility after unsuccessful medical intervention.

The purpose of this qualitative descriptive study was to explore the phenomenon of women's experience with infertility in the aftermath of unsuccessful medical treatment. A purposive sample of 22 women between the ages of 33 and 48 years participated in a hermeneutic–phenomenological research process and were interviewed an average of 3.9 years after unsuccessful medical treatment. Women described the existential challenges to their sense of self, their identity, and the meaning and purpose of life. The paradoxical dimensions of loss and opportunity in their experience contributed to an altered view of themselves and their world. Infertility and its role as a life-defining experience pervaded their stories of living with infertility after unsuccessful treatment. Health care professionals are advised to assess women's overall well-being, mental health status with particular attention to spiritual well-being, and their social support network as a basis for determining supportive services that may be required in the wake of unsuccessful treatment for infertility.
Public Perceptions of Forest Management in North Central Arizona: The Paradox of Demanding More Involvement but Allowing Limits to Legal Action

Because Arizona’s population is both dynamic and diverse (in terms of age, income, education, length of time living in Arizona, and rural or urban setting), we were particularly interested in examining how demographic factors relate to restoration policy preferences. Contextual factors, including setting (geographic and residential), have been identified as important dimensions in the study of social acceptability of natural resource issues (Shindler et al. 2002a, Brunson and Shindler 2004). Demographic information provides clues as to trends in policy preferences and may indicate how agencies can direct their efforts to communicate to the public. For instance, agencies may wonder if there is a difference between rural and urban preferences. Brunson and Evans (2005) found that rural residents in Utah were less likely than metropolitan residents to believe federal agencies can use prescribed fire effectively and that rural respondents had less trust of federal officials. Agencies also may ask, are younger or older people more receptive to restoration or limits to environmental litigation? Does education level influence whether limitations to participation are acceptable, or does length of residency in north central Arizona influence policy perceptions? Examining these contextual issues as they relate to policy preferences will help managers and policymakers better understand the publics they serve and may provide insights on the social and political context for restoration in a rapidly changing state such as Arizona (Hall and Bigler-Cole 2001).
Outcomes Following Cubital Tunnel Surgery in Young Patients: The Importance of Nerve Mobility.

Purpose To investigate the outcomes following surgical management of unstable and stable ulnar nerves at the elbow in young patients. Methods We retrospectively reviewed the charts of 67 patients who were 30 years old or younger when they underwent primary cubital tunnel surgery at our institution over a 10-year period. In 34 (45%) of these patients, the ulnar nerve either subluxated or perched on the medial epicondyle with elbow flexion and made up the "unstable" cohort. The remaining 42 patients made up the "stable" cohort. Preoperative, intraoperative, and postoperative data were obtained from the patients' charts. Thirty-nine patients completed the following outcome measures: Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), visual analog scale (VAS) for pain and treatment satisfaction, return to sport or full activities, and the presence of persistent symptoms. Results At an average of 5.6 years following surgery, the unstable cohort had a significantly lower QuickDASH score (6.4 vs 18.6) and a significantly higher VAS for treatment satisfaction (8.7 vs 5.9) compared with the stable cohort. The unstable cohort was also significantly less likely to experience residual symptoms (43% vs 94%), persistent numbness (39% vs 44%), or persistent tingling (22% vs 56%) compared with the stable cohort. Within the stable cohort, patients who underwent simultaneous carpal tunnel release exhibited improved VAS and QuickDASH scores compared with patients who did not. There were no differences in time to return to sports or full activities or pain VAS between the two groups. Conclusions Surgical management of young patients with symptomatic, unstable ulnar nerves results in superior subjective outcomes compared with surgery in young patients with stable ulnar nerves. Type of study/level of evidence Therapeutic III.
Molecular Dynamics Study on the Influence of Additives on the High-Temperature Structural and Acidic Properties of ZSM-5 Zeolite

The ReaxFF reactive force field method was used to study the effect of various dopants on the thermal stability and melting process of the zeolites. The force field parameters were fitted against quantum mechanical data for Si/Al/Fe/O/H interactions. Molecular dynamics (MD) simulations were performed using an isothermal–isobaric (NPT) ensemble to investigate the thermal stability of different zeolite frameworks. The zeolite frameworks simulated consisted of silicalite, Al-doped HZSM-5, Fe-doped ZSM5, hydrated ZSM5, and Al- and Fe-doped hydrated HZSM-5. The Lindemann index was used to characterize the melting process. MD results indicate that most of the zeolite frameworks remain stable until 3500 K on the nanosecond time scales accessible to MD simulations. Above 3500 K, the frameworks start to collapse inward, indicating the loss of porous channels. The melting process is initiated due to the disruption of the Si–O–Si network. The presence of water weakens this network due to the hydrogen transfer from w...
Some Derivatives of 5-hydroxy-2-pyridone(2,5-dihydroxypyridine):

The syntheses of 5-hydroxy-6-bromo-2-pyridone, 5-hydroxy-6-nitroso-2-pyridone, 3-bromo-5-acetoxy-2-pyridone, and 3-nitro-5-acetoxy-2-pyridone are described.
Regional Molecular Genetic Key of Thirteen Snow Pool Aedes Species (Diptera: Culicidae) in Northern Colorado

Snow pool Aedes mosquitoes are identified easily and accurately by microscopic examination of 4th instars or male genitalia. Early instars and females cannot be identified accurately. We demonstrate that restriction fragment-length polymorphisms (RFLP) in the internal transcribed spacer (ITS) of the nuclear ribosomal DNA cistron are specific to each of 13 snow pool Aedes species found in northern Colorado. The ITS was amplified by the polymerase chain reaction (PCR) and digested with AluI and MspI restriction endonucleases. Differences in the sizes of digested fragments among the 13 species were so slight that they could only be resolved with polyacrylamide gel electrophoresis and visualized with silver staining. A key to species found in the Rocky Mountains of northern Colorado was constructed using the PCR-RFLP patterns. Three of the species were collected in California and had identical PCR-RFLP patterns, indicating that restriction sites in the ITS may be conserved within some species.
Multifaceted Reactions of P(CH2OH)3 with Rhenium(V) Precursors. Synthesis, Characterization, and X-ray Structural Studies of trans,trans,trans-[ReO2{P(CH2OH)3}2- (py)2]Cl, trans,cis,cis-[ReO2{P(CH2OH)3}2(py)2]Cl, and Novel Alkoxide [Re(O)(μ-O)- (P{CH2OH}3)(μ-η2-P{CH2OH}2CH2O)]4

The reaction of the water-soluble monophosphine tris(hydroxymethyl)phosphine (THP, 1) with [ReO2(py)4]Cl produced either trans,trans,trans-[ReO2(THP)2(py)2]Cl (3, referred to as trans-[ReO2(THP)2(py)2]Cl throughout the text) or trans,cis,cis-[ReO2(THP)2(py)2]Cl (4, referred to as cis-[ReO2(THP)2(py)2]Cl throughout the text) depending on the reaction conditions. In contrast, the reaction of THP with ReO2I(PPh3)2 in biphasic media produced the novel, neutral, cyclic tetranuclear, rhenium(V) alkoxide 5 in low yields. A similar reaction of bis(hydroxymethyl)phenylphosphine (2) with [ReO2(py)4]Cl produced the trans,trans,trans-[ReO2{PPh(CH2OH)2}2(py)2]Cl complex (6, referred to as trans-[ReO2{PPh(CH2OH)2}2(py)2]Cl throughout the text) in high yields. All compounds were characterized by 31P, 1H, and 13C NMR spectroscopy and mass spectroscopy. X-ray data for 3: monoclinic, C2/c, a = 17.7964(11) A, b = 8.8972(6) A, c = 15.3247(9) A, β = 97.683(1)°, Z = 4, R = 0.0179 (Rw = 0.0426). X-ray data for 4: monoclinic, ...
A Test of the Quality Circle Approach to Problem Solving

Sixty employees from a large government installation were surveyed on the question, “How I solve problems and insure quality in my work environment.” Thirty of the participants were active members of Quality Circle (QC) groups, and thirty had never been members. The narrative responses were scored on references to (1) problem avoidance/identification, (2) problem resolution, and (3) individual responsibility/authority. Contrary to expectations, nearly every statistical test showed the QC members to exhibit less problem recognition, less individual initiative, and less willingness to accept authority than those employees who had never joined a QC group. The discussion emphasizes the continuing need for a method of evaluation of the claims of certain organizational development programs.
Palliative and prophylactic benefits of continuously administered dopaminomimetics in Parkinson's disease.

Motor response complications that ultimately affect most parkinsonian patients appear related to altered dopaminergic mechanisms at both the presynaptic and postsynaptic levels. «Wearing-off» phenomena reflect a shortened duration of the antiparkinsonian action of levodopa, caused initially by the reduced capacity of the degenerating nigrostriatal system to store dopamine. Later, secondary changes in postsynaptic structures contribute substantially to these complications as well as to the changes in levodopa dose-antiparkinsonian response relation and the threshold for levodopa-induced dyskinesias that underlie «on-off» fluctuations and «peak-dose» dyskinesias
Changes in Optical Properties of Plasmonic Nanoparticles in Cellular Environments are Modulated by Nanoparticle PEGylation and Serum Conditions

When plasmonic nanoparticles (NPs) are internalized by cells and agglomerate within intracellular vesicles, their optical spectra can shift and broaden as a result of plasmonic coupling of NPs in close proximity to one another. For such optical changes to be accounted for in the design of plasmonic NPs for light-based biomedical applications, quantitative design relationships between designable factors and spectral shifts need to be established. Here we begin building such a framework by investigating how functionalization of gold NPs (AuNPs) with biocompatible poly(ethylene) glycol (PEG), and the serum conditions in which the NPs are introduced to cells impact the optical changes exhibited by NPs in a cellular context. Utilizing darkfield hyperspectral imaging, we find that PEGylation decreases the spectral shifting and spectral broadening experienced by 100 nm AuNPs following uptake by Sk-Br-3 cells, but up to a 33 ± 12 nm shift in the spectral peak wavelength can still occur. The serum protein-containing biological medium also modulates the spectral changes experienced by cell-exposed NPs through the formation of a protein corona on the surface of NPs that mediates NP interactions with cells: PEGylated AuNPs exposed to cells in serum-free conditions experience greater spectral shifts than in serum-containing environments. Moreover, increased concentrations of serum (10, 25, or 50 %) result in the formation of smaller intracellular NP clusters and correspondingly reduced spectral shifts after 5 and 10 h NP-cell exposure. However, after 24 h, NP cluster size and spectral shifts are comparable and become independent of serum concentration. By elucidating the impact of PEGylation and serum concentration on the spectral changes experienced by plasmonic NPs in cells, this study provides a foundation for the optical engineering of plasmonic NPs for use in biomedical environments.
Education and Discomfort

It was late in the evening and I had just come home after a day of teaching, filled with the combination of exhaustion, tension, and sometimes pure joy that accompanies working in schools. There was something waiting for me, a letter from Teachers College, Columbia University. I opened it with much trepidation. But the news was good.
Memory in autoimmune NMDA receptor encephalitis: An issue for B cells and patients

This scientific commentary refers to ‘Human cerebrospinal fluid monoclonal N -methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis’, by Kreye et al. (doi:10.1093/brain/aww208) . Autoimmune NMDA receptor (NMDAR) encephalitis was first described in 2007 as an immunotherapy-responsive syndrome that is often paraneoplastic. Ovarian teratoma is the most commonly associated tumour (Titulaer et al. , 2013). NMDAR encephalitis now serves as a pathophysiological and therapeutic paradigm for several newly recognized autoimmune synaptic disorders affecting the CNS. Its distinctive clinical spectrum includes psychiatric and behavioural manifestations, cognitive deficits, abnormal movements (particularly in children), seizures (most commonly as the initial manifestation in males), autonomic instability, central hypoventilation and altered consciousness (Titulaer et al. , 2013). IgG autoantibodies targeting the NR1 subunit of the NMDA receptor are implicated in the syndrome pathogenesis, and their detection—particularly in the CSF—aids diagnosis. The clinical benefit of therapies that reduce circulating antibody levels and B cell numbers supports the pathogenicity of NMDAR-IgG, as do experimental studies in vitro and in vivo . The binding of patients’ CSF IgG to live hippocampal neurons decreases the density of NMDAR clusters by inducing endocytosis and lysosomal degradation of antibody-NMDAR complexes. After the autoantibody is removed, newly synthesized NMDARs repopulate the plasma membrane. Endocytosis is accompanied by a selective reduction in synaptic NMDAR-mediated currents (Hughes et al. , 2010; Moscato et al. , 2014). Mice injected intrathecally with patients’ CSF exhibit memory impairments and behavioural abnormalities, while human NMDAR-specific IgG progressively …
Mir-222-221 Induce Dexamethasone Resistance by Targeting BBC3/PUMA in Human Multiple Myeloma

Abstract 1419 ABSTRACT Dexamethasone is a conventional drug that effectively induces multiple myeloma (MM) cell death at presentation and in relapsed patients and continues to be used against MM alone or in combination with the new therapeutic agents. However, still remain unclear the mechanism of Dexamethasone resistance in clinic. We now report new mechanisms of Dexamethasone resistance implicating microRNAs (miR). MicroRNAs are noncoding small RNAs (18–25nt) that play an important role in the regulation of gene expression. Recently our profiling study in MM1S and MM1R cells has shown that miR-222-221 are highly expressed in MM1R cells as compared with MM1S cells. Our further investigation showed that enforced expression of miR-222-221 could render cells resistant to Dexamethasone and that the resistance to this drug could be partially restored by ectopic expression of PUMA without 39UTR region. The list of microRNAs regulators for PUMA (BBC3) 39UTR region in targetscan website includes miR-221 and miR-222. We also found a negative relationship between miR-222-221 levels and therapeutic response in clinical samples by using Q-RT-PCR, IHC and ISH methods. So we propose that miR-222-221 could target PUMA to induce Dexamethasone resistance in MM. Ectopic expression of miR-222-221 in MM1S cells resulted in decreased expression of PUMA protein and mRNA, whereas knockdown expression of miR-222-221 could restore PUMA expression in MM1S cells. Notably, miR-222-221-transfected MM1S cells became resistance to Dexamethasone as compared to vector-treated cells. Further, the knockdown of miR-222-221 sensitizes the MM1R cells to Dexamethasone-induced cell growth arrest and apoptosis. These findings indicate that the miR-222-221 play a significant role in regulation of PUMA expression level and could be potential targets for restoring PUMA expression and response to Dexamethasone therapy in a subset of MM patients. We are currently investigating the role of miR-222-221 in Dexamethasone resistant in vivo using well established mouse xenograft models of MM. Disclosures: No relevant conflicts of interest to declare.
Presenteeism in nursing: An evolutionary concept analysis.

Abstract Background Presenteeism is an emerging concept in nursing that has been linked to increased health care costs, patient medication errors and falls, and negative nurse well-being. However, prior work has utilized various definitions and antecedents. Clarity on the significance, development, and consequences of presenteeism in nursing is needed. Purpose This concept analysis seeks to understand the application of presenteeism within nursing workforce literature and in the broader workforce context. Method Rodgers' evolutionary concept analysis method was used. Discussion The proposed definition of presenteeism as the act of being physically present at work with reduced performance can be attributed to multiple antecedents. These include nurse health, professional identity, work–life balance, and work environment. The prevalence of these antecedents with high rates of presenteeism among nurses and consequences point to the need for interventions. Conclusion These findings can guide development of future interventions and policies that address the broader context of factors leading to presenteeism.
Fast parametric relationships for the large-scale reservoir simulation of mixed CH4-CO2 gas hydrate systems

A recent Department of Energy field test on the Alaska North Slope has increased interest in the ability to simulate systems of mixed CO2-CH4 hydrates. However, the physically realistic simulation of mixed-hydrate simulation is not yet a fully solved problem. Limited quantitative laboratory data leads to the use of various ab initio, statistical mechanical, or other mathematic representations of mixed-hydrate phase behavior. Few of these methods are suitable for inclusion in reservoir simulations, particularly for systems with large number of grid elements, 3D systems, or systems with complex geometric configurations. In this work, we present a set of fast parametric relationships describing the thermodynamic properties and phase behavior of a mixed methane-carbon dioxide hydrate system. We use well-known, off-the-shelf hydrate physical properties packages to generate a sufficiently large dataset, select the most convenient and efficient mathematical forms, and fit the data to those forms to create a physical properties package suitable for inclusion in the TOUGH+ family of codes. The mapping of the phase and thermodynamic space reveals the complexity of the mixed-hydrate system and allows understanding of the thermodynamics at a level beyond what much of the existing laboratory data and literature currently offer. Presents a toolkit for representing CO2-CH4 hydrate system properties numerically.Creates smooth functions for hydrate physical properties suitable for simulations.Supports field tests of injection and production from gas hydrate reservoirs.
Achievement Tests for Beginning and Intermediate Tennis

(1950). Achievement Tests for Beginning and Intermediate Tennis. Research Quarterly. American Association for Health, Physical Education and Recreation: Vol. 21, No. 3, pp. 303-321.
Infection or Glioma? The False Dilemma of Primary Central Nervous System Histiocytic Sarcoma.

Background Primary central nervous system (CNS) histiocytic sarcoma is an extremely rare lymphoproliferative disorder that affects the CNS and behaves aggressively. Only 27 cases of primary CNS histiocytic sarcoma have been reported. The paucity of literature on this entity has made diagnosis and treatment difficult both for the surgeon and the pathologist. Case Description In this case of primary CNS histiocytic sarcoma, a middle-aged woman presented from an outside institution with a supposed cerebellar abscess. Intraoperative frozen pathology was initially interpreted as high-grade glioma; however, final pathology demonstrated histiocytic sarcoma. Conclusions This report makes a significant contribution to the literature on this rare malignant disease by outlining a similar presentation among several cases and providing a thorough overview of existing criteria for diagnosis and management.
Outcomes utilizing intensity‐modulated radiotherapy in oropharyngeal cancers: Tonsils versus base of tongue

Background The purpose of this study was to present the outcomes of oropharyngeal cancers treated with intensity-modulated radiotherapy (IMRT) especially the differences between tonsillar and base of tongue (BOT) primaries. Methods Retrospective analysis of 124 patients with biopsy proven squamous cell carcinomas of the oropharynx, treated with IMRT. Results Human papillomavirus (HPV) association correlated with improvement in survivals in both tonsillar and BOT primaries. At the 2-year median follow-up, the cumulative incidences of locoregional recurrences were 8% in both the tonsil and BOT groups (P = .76) but the distant metastases were 8% in the tonsil group versus 26% in the BOT group (P = .009). Thirty percent of tonsil primaries has ≥N2c neck disease as compared to 54% of BOT. Incidence of distant metastases increases with advanced nodal classification, especially >N2c. Conclusion Even though the locoregional controls are excellent with IMRT and chemotherapy, these patients continue to fail distantly, particularly significant for the BOT group and for nodal stage >N2c.
Queering PR: Directions in theory and research for public relations scholarship

This article presents an historical overview of queer activism and inquiry, advocating for queer theorizing in public relations, and outlining future directions for theory building. It proposes mak...
The effect of history of abnormal pap smear or preceding HPV infection on the humoral immune response to Quadrivalent Human Papilloma virus (qHPV) vaccine in women with systemic lupus erythematosus.

ABSTRACT Objective : To determine if natural human papillomavirus (HPV) infection would induce an anamnestic response to quadrivalent (qHPV) vaccine in women with Systemic Lupus Erythematosus (SLE)...
Monolithic electrochemical cells for overall water splitting

Abstract Electrochemical cells are widely used for hydrogen production by electrochemical water splitting (EWS). Even though much progress in the electrochemical cells has been made, the mainstream device architecture is limited to batch-type configuration which leads to increased volume and extra need of products separation. Thus, it is still desirable to develop an electrochemical cell with a monolithic device architecture. Herein, we report a monolithic electrochemical cell (MEC) consisting of Pt nanoparticles (NPs) and FeNi 3 /Fe 3 O 4 hybrid NPs anchored to laser induced graphene (LIG) electrodes directly patterned on both sides of polyimide film. When serving as an individual electrode, Pt/LIG and FeNi 3 /Fe 3 O 4 /LIG exhibit overpotentials of 90 mV and 253 mV at 10 mA/cm 2 for HER and OER, respectively. When they are assembled as a MEC for EWS, it displays a voltage of 1.58 V at 10 mA/cm 2 . This novel device architecture omits the need of multiple assembling steps for manufacturing the full cells. In addition, the rapid and continuous laser synthesis strategy is quite simple, economic, and easily scaled up, which offers numbers of advantages over traditional batch-to-batch methods and thus offering a universal route to fabricating MECs via in - situ synthesis of various electrocatalysts embedded in LIG electrodes for other electrochemical reactions.
Genetic Analysis of Cytoskeletal Protein Function in Yeast

It has become clear in recent years that eukaryotic cells have an internal structure, called the cytoskeleton, which is of basic importance in many, if not all, cellular functions. Many of the major proteinaceous elements of the cytoskeleton have been identified, often with characteristic morphological structures (e.g., microfilaments, intermediate filaments, microtubules). However, the function of these proteins and structures is frequently unclear and sometimes entirely obscure. One way, in principle, that one can associate a protein or structure with a function is to obtain mutations in the gene(s) specifying the protein(s) and to observe the phenotype of the mutants. Carrying out this scheme in practice, however, requires considerable facility with the basic genetics of the organism under study and that the gene(s) not be present in more than one equivalent copy per haploid genome. Very few organisms have been studied which meet these conditions: first among them is the budding yeast (Saccharomyces cerevisiae), which has a very small genome, grows vegetatively as either a haploid or diploid, has an extraordinarily convenient, powerful and extensively developed genetic system (including advanced recombinant DNA methods) and contains just one copy of the actin and β-tubulin structural genes.
Conclusion and Challenges

This chapter concludes graphics recognition approaches that were comprehensively discussed in the earlier chapters. In brief, it highlights the current state-of-the-art techniques for graphics recognition: their merits and demerits. Recent trends on several other different (but, major) real-world problems are also discussed. Further, a few examples will be demonstrating to see whether graphics recognition can be extended to other domains, such as medical imaging.
Comparative Analysis of a Coaxial Magnetic Gearbox with a Flux Concentration Halbach Rotor and Consequent Pole Rotor Typology.

By utilizing magnetic field space modulation magnetic gearboxes (MGs) are able to create speed amplification without any physical contact [1–3]. An example of a flux-focusing coaxial MG is illustrated in Fig. 1. This coaxial MG consists of an inner rotor 1 that contains $p_{1} = 4$ pole-pairs an outer rotor 3 with $p_{3} = 13$ pole-pairs and a central ferromagnetic segment central rotor 2 that consists of $n_{2} = 17$ pieces. The $n_{2}$ ferromagnetic segments serve to modulate the inner and outer rotor magnetic fields. In order to create the highest level of field coupling between the inner and outer rotors the number of ferromagnetic segments must be chosen to satisfy $n_{2} = p_{1}+p_{3}$. With this condition satisfied the rotor angular velocity relationship between each rotor is $\mathrm{w}_{2} \mathrm{p}_{2} = \mathrm{w}_{3} \mathrm{p}_{3}+ \mathrm{w}_{1} \mathrm{p}_{1}$ where the subscript denotes rotor number. If the outer rotor is fixed $( \omega _{3} = 0)$ the torque will be maximized and the gearing ratio will be $\mathrm{w}1 = $ Gw 2 where $\mathrm{G} = n_{2}/ p_{1}$. For the example MG shown in Fig. 1 the gear ratio is $\mathrm{G} = 4.25$. In order to try to increase the torque density of a MG a range of different coaxial type rotor typologies have recently been investigated [4–14]. Along with the flux focusing MG design two other coaxial radial type MG rotor typologies that have been shown to create high torque density are the flux concentration Halbach rotor typology [15] and the consequent pole triple-PM rotor MG typology [16]. In this paper, these two design typologies are compared for the first time. The objective is to provide an idealized comparative analysis of the two competing typologies and then present the experimental design and testing of the best design.
Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

Enzymatic inhibition has proven to be a successful modality for the development of many small-molecule drugs. In recent years, small-molecule-induced protein degradation has emerged as an orthogonal therapeutic strategy that has the potential to expand the druggable target space. Focal adhesion kinase (Fak) is a key player in tumor invasion and metastasis, acting simultaneously as a kinase and a scaffold for several signaling proteins. While previous efforts to modulate Fak activity were limited to kinase inhibitors with low success in clinical studies, protein degradation offers a possibility to simultaneously block Fak’s kinase signaling and scaffolding capabilities. Here, we report the development of a selective and potent Fak degrader, PROTAC-3, which outperforms a clinical candidate, defactinib, with respect to Fak activation as well as Fak-mediated cell migration and invasion. These results underline the potential that PROTACs offer in expanding the druggable space and controlling protein functions ...
A Practitioner’s Guide to Optimizing the Interactions Between Modelers and Domain Experts

As model-based approaches to Systems Engineering (SE) grow in popularity, the dynamic information exchange between modelers and domain experts is becoming a more common form of engineering collaboration. Typically, modelers and domain experts do not possess much shared knowledge at the beginning of a domain modeling effort, and gradually learn from each other throughout the process. This paper presents a set of Model-Based Systems Engineering (MBSE) practitioner-based techniques that modelers and domain experts can use to have more efficient and effective interactions during model development. The techniques are presented in the context of existing literature, and further validated by the results of an exploratory survey given to MBSE practitioners, thereby forming the basis for a more standardized process of multidisciplinary knowledge sharing than exists today. The intent is that a team of modelers and domain experts could then apply these practical techniques to their project to reduce the cost of multidisciplinary translation, enabling faster model development while promoting model quality: readability, accuracy, and completeness.
A Hierarchical Approach to Self-Timed Circuit Verification

Self-timed circuits can be modeled in a link-joint style using a formally defined hardware description language. It has previously been shown how functional properties of these models can be formally verified with the ACL2 theorem prover using a scalable, hierarchical method. Here we extend that method to parameterized circuit families that may have loops and non-deterministic outputs. We illustrate this extension with iterative self-timed circuits that calculate the greatest common divisor of two natural numbers, with circuits that perform arbitrated merges non-deterministically, and with circuits that combine both of these.
Introduction: The Reactionary in the Fan and the Fan in the Reactionary:

This special issue explores the intersection of reactionary politics and fandom. Fandom has traditionally been thought of as progressive, but this has been limited and limiting. Moreover, considera...
Array Pattern Synthesis with Prescribed Nulls

Research into antenna array pattern synthesis started with lows sidelobe amplitude tapers. Later, adaptive nulling and null synthesis became very important. Contributions by Dr. Hans Steyskal gave tremendous insight into array pattern nulling. This paper applies his concepts to different adaptive array scenarios to provide insight into distortions in the adapted pattern.
The restorative potential of coastal walks and implications of sound

A growing body of research suggests blue spaces (oceans and freshwater) can be restorative environments and that sound can influence a restorative experience. This study uses a random cross-over fi...
Abstract TP396: Improving Documentation of Blood Pressure and Neurological Assessments in Post Alteplase Patients

Introduction: Patients who receive alteplase for acute ischemic strokes are at a high risk for conversion to a hemorrhagic stroke and must be monitored closely through frequent vital signs and neur...
Predicting Survival with Mobile ECMO: A Single-Center Evaluation

Purpose Extracorporeal membrane oxygenation (ECMO) treats acute reversible severe heart/lung failure in adults at high mortality risk. While often initiated in-hospital, ECMO's portability allows for experienced centers to implant it off site. We examined the impact mobile ECMO on survival in patients with severe cardiopulmonary failure. Methods This is a retrospective review of patients with in-hospital or mobile ECMO from January 2013 to October 2019. Participants were included if they were ≥ 18 years old and received ECMO performed at Hartford Hospital or through the mobile, “ECMO on the Go” unit. The Survival After Veno-Arterial ECMO (SAVE) and Respiratory ECMO Survival Prediction (RESP) scores were calculated. The primary endpoints were 48-hour and hospital discharge survival. Results We included 201 patients with a median (25th, 75th percentile) age 54.0 (39.5, 64.0) years and median ECMO time of 5.0 (3.0, 8.0) days. VA (median SAVE score -6.5 [-9.0, -3.0]) and VV ECMO (median RESP score 2.0 [-1.0, 5.0]) were initiated in 51.7% and 48.3% of patients, respectively. Mobile ECMO was initiated in 61 (30.3%) patients. 48-hour survival was higher in the mobile (65.6%) vs hospital ECMO patients (55.7%, p=0.192). Survival to hospital discharge was also higher with mobile (59.0%) vs hospital ECMO patients (41.4%, p=0.097). Baseline SAVE and RESP scores were higher in patients surviving to 48-hr and hospital discharge (p Conclusion We showed that mobile ECMO is effective for treatment of severe cardiopulmonary failure refractory to standard modalities. Mobile ECMO trended towards improved survival compared with in-hospital initiation. SAVE and RESP scores may be predictive of survival using mobile ECMO applications.
Changes in L2 pronunciation: 25 years of intelligibility, comprehensibility, and accentedness

Abstract This special issue revisits an extraordinarily influential paper for L2 pronunciation research and teaching (Munro & Derwing, 1995) by looking again at the original paper with new eyes and new analyses. The special issue also includes invited papers addressing current approaches based on the three key constructs in Munro and Derwing (1995): Intelligibility, comprehensibility, and accentedness. Papers in the issue include a reconsideration of the Intelligibility and Nativeness principles from Levis (2005), applications of the constructs to L2 Spanish (Nagle & Huensch), a consideration of how everyday L2 use affects comprehensibility (Zielinski & Pryor), long-term effects of intensive instruction (French, Gagne & Collins), influences on listener reaction to L2 speech (Isaacs & Thomson), empirical evidence for the dynamic nature of comprehensibility (Trofimovich et al.), a study on ELF intelligibility and functional load considerations (Thir), the relationship between comprehensibility and social evaluation of speech (Vaughn & Whitty), and one book review.
The Milky Way and its gas: Cold fountains and accretion

The Milky Way is acquiring gas from infalling high-velocity clouds. The material enters a disk-halo interface that in many places is populated with HI clouds that have been ejected from the disk through processes linked to star formation. The Smith Cloud is an extraordinary example of a high-velocity cloud that is bringing > 106 M☉ of relatively low metallicity gas into the Milky Way. It may be part of a larger stream, components of which are now passing through the disk.
Ethnicity in modern rewritings of Bashshār ibn Burd: “free thinker,” “libertine” or “love poet”?

Modern scholarship on and translations of Bashshār ibn Burd (d. 784), especially into English, adopt his Persian origin as a method for, or at least as a key, to interpreting and understanding his ...
Left-Wing Xenophobia in Europe

Given rising populist nationalism and multiplying meanings of “right” and “left,” this paper assesses whether Europeans who identify as extremely left-wing on the political spectrum hold anti-immigrant attitudes. In contrast to right-wing xenophobes, we further examine whether the political left, who conventionally emphasize class conflict, oppose immigrants less for cultural reasons and more for materialist reasons. We also consider whether socioeconomic status and values traditionally associated with the political left – favoring redistributive policies, egalitarianism, or social rights to benefits and services for immigrants – temper left- more than right-wing xenophobia. We find that a surprisingly large share of those who identify as far left do express extremely xenophobic attitudes, and we profile them in contrast to far right xenophobes. With logistic regression analysis of nine waves of the European Social Survey (2002-2018), we find that, all things equal, socioeconomic status influences far left xenophobia more than far right xenophobia, but inegalitarian values, less support for redistributive policies, and welfare chauvinism can only partially account for far left xenophobia and unexpectedly do not distinguish it from far right xenophobia. This implies that far left parties might adopt or anti-immigrant policies to try to retain their loyal voters, even though such policies do not comport with broader left-wing values and may increase racial and ethnic inequality. Controlling for demographic and attitudinal differences reduces the probability of xenophobia among the far left by about sixty percent, but there remains some residual anti-immigrant attitudes among this group still to be explained.
Understanding the Business Value of Information Technology Investments: Theoretical Evidence from Alternative Market and Cost Structures

This paper develops a series of two-stage duopoly models of quality- price competition and a series of monopoly models of quality-price choice in order to examine the impact of information technology (IT) investments on firm profit, firm productivity, and consumer welfare. We solve the duopoly and monopoly models for four cost functions, where each function makes a different assumption about the form of the marginal cost of production. These models are used to conduct a two-by-four comparison [(monopoly, duopoly) ii¾? (four cost functions)] of the impact of IT investments on economic performance. The analysis reveals that together market structure and cost structure play a critical role in determining the form of the relationship between IT investment and economic measures. Specifically, moving from monopoly to duopoly and moving from zero marginal cost to marginal cost as a function of quality increase the number of economic measures for which the directional effects of IT investment are ambiguous, or depend on model parameter values.
Competitive Entertainment: Implications of the NFL Lockout Litigation for Sports, Theatre, Music, and Video Entertainment

The 2011 NFL lockout reveals profound changes in the labor and product markets for the entire entertainment industry, driven by a revolution in technology. This article explores the revolution in the professional sports, theatre, and movie-making industries and concludes that it is fragmenting production, blurring the boundaries between labor markets and product markets, and introducing new forms of competition. As a result, the labor exemptions to the antitrust laws, which featured prominently in the NFL controversy are becoming less relevant, shifting the law's policing of competition to antitrust rule-of-reason analysis, where counterpoises such as labor unions are inactive, and making overaggressive interpretation and enforcement of copyright law a major danger to realization of the new markets' potential.
Evaluating Sparse Data Storage Techniques for MPI Groups and Communicators

In this paper we explore various sparse data storage techniques in order to reduce the amount of memory required for MPI groups and communicators. The idea behind the approach is to exploit similarities between the objects and thus store only the difference between the original process group and the resulting one. For each technique, we detail the memory saved compared to the currently used implementations, and present a runtime decision routine capable of choosing dynamically the most efficient technique for each scenario. Furthermore, we evaluate the performance impact of the new structures using point-to-point benchmarks as well as an application scenario over InfiniBand, Myrinet and Gigabit Ethernet networks.
Cowboy Republic: Six Ways the Bush Gang Has Defied the Law [Book Foreword and Introduction]

This book, "Cowboy Republic," describes the six most important ways the Bush Administration has weakened the rule of law. They include the war of aggression in Iraq, the torture of prisoners, summary execution and willful killing, the Guantanamo gulag, spying on Americans, and refusing to execute the law. Marjorie Cohn, Professor at Thomas Jefferson School of Law, and President of the National Lawyers Guild, explains what we can do to remedy the administration's breaches of statutory, constitutional, and international law, including political and legal remedies. This posting contains the Foreword and Introduction of the book.
Evaluation of Infiltration Basin Performance on Coarse Soils

AbstractInfiltration basins are commonly utilized to reduce or eliminate stormwater runoff and are commonly located on coarse soils due to relatively high infiltration rates. Forty infiltration basins in Florida were included in this field study to evaluate whether basin infiltration rates varied significantly from their designed infiltration rates. Basins were located among Leon, Alachua, and Marion counties in Florida, while watershed land uses were equally divided between Florida Department of Transportation and residential developments. Generally, six test sites within each basin were selected for infiltration rate measurement by double-ring infiltrometer (DRI). Also, a soil boring was collected from each test site for analyses, including soil texture, bulk density, and organic matter content. Infiltration rates were log-transformed and statistical analysis was used to determine if DRI measurements were significantly different from design rates. Basin soil textures were well distributed between sand, ...
Pilot Study of a Radiation Oncology Telemedicine Platform

Purpose: A pilot study was undertaken to develop an integrated telemedicine platform for radiation oncology at Memorial Sloan-Kettering Cancer Center (MSKCC) and its regional sites. The platform consisted of a computer system with simultaneous display of multiple live data portals including 1) video-conferencing between physicians, 2) radiology, and 3) radiation treatment-planning system (RTPS). Methods and Materials: Two MSKCC regional centers were set up with a widescreen monitor, a dedicated computer, and a web camera with microphone. Each computer ran a Microsoft operating system, utilized video-conferencing software, and connected to the MSKCC Ethernet. This allowed for access to the health information system, radiology (web-based picture archiving and communication systems), RTPS, shared network drives and the internet. Results: After 3 months, physicians at two MSKCC sites were successfully able to implement the proposed telemedicine platform. A small sample of cases (prostate, breast, head and neck, and anal cases) were tested. Radiology images, radiation treatment volumes and plans, and portal images were reviewed. Side-by-side comparison of contouring techniques was performed. The platform allowed physicians to remotely review details of cases efficiently. The interactions of the telemedicine platform improved clinical understanding of each case and often resulted in contouring changes. Conclusion: From this experience, we feel that telemedicine could have a significant clinical impact on patient care, especially at centers with satellite clinics. The future goal of the system will be the development of a virtual tumor board for radiation oncologists. We envision the simultaneous display of multiple clinical components, including face photo, pathology, tumor images/videos of procedures, radiology, RTPS, and anatomy/contouring databases, on one screen surface.
Creative health education through puppetry.

(1978). Creative Health Education through Puppetry. Health Education: Vol. 9, No. 1, pp. 40-41.
Explanatory Interface in Interactive Design Environments

Explanation is an important issue in building computer-based interactive design environments in which a human designer and a knowledge system may cooperatively solve a design problem. We consider the two related problems of explaining the system’s reasoning and the design generated by the system. In particular, we analyze the content of explanations of design reasoning and design solutions in the domain of physical devices. We describe two complementary languages: task-method-knowledge models for explaining design reasoning, and structure-behavior-function models for explaining device designs. Interactive Kritik is a computer program that uses these representations to visually illustrate the system’s reasoning and the result of a design episode. The explanation of design reasoning in Interactive Kritik is in the context of the evolving design solution, and, similarly, the explanation of the design solution is in the context of the design reasoning.
Intraluminal small intestinal pressures in normal patients and in patients with functional gastrointestinal disorders.

Summary 1.A pressure-sensitive radiotelemetering capsule has been used to obtain small intestinal intraluminal pressure records from 12 convalescent hospital patients without symptoms of functional gastrointestinal disease and 10 patients without organic disease complaining of "functional" symptoms. 2.The intraluminal pressure records were generally similar to those obtained by other detecting and recording systems. There was marked temporal variation in the recorded complexes, requiring long records for adequate interpretation. 3.No difference existed in the amplitude or frequency distributions of type I waves in the 2 groups studied, but rhythmic type III activity was much more common in records of patients with functional disease.
Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation.

Abstract v-rel is a viral oncogene that evolved from turkey c-rel, an NF-kappa B-related transcription factor. Numerous structural alterations record the evolutionary selection of v-rel and distinguish it from c-rel. To evaluate the biological significance of these alterations, we constructed a set of five c/v-rel hybrids in which three mutation clusters (c-Rel amino acids 1 to 97,222 to 302, and 328 to 598) were differentially distributed. These constructs, in addition to parental v-rel and c-rel and two C-terminal deletion mutants of c-rel, were expressed from a retroviral vector. An analysis of cells infected with each of the nine viruses revealed that mutations in all three domains contributed to the ability of v-rel to induce two endogenous c-rel target genes, major histocompatibility complex (MHC) class I and class II, in the B-cell line DT95 as well as MHC class II in normal splenocytes. The analysis revealed a strong nonlinear correlation between the ability of a Rel protein to induce expression of MHC proteins and its capacity to produce splenic tumors and establish in vitro transformation. This correlation is consistent with the hypothesis that v-rel transforms by constitutively altering expression of genes regulated by c-rel and in this way simulates events associated with immune response-linked proliferation of cells of hematopoietic origin. Further, the 16 carboxy-terminal amino acids of c-Rel were identified as a domain responsible for producing a cytotoxic and/or cytostatic effect in DT95. Because this effect is likely to differentially influence induction of MHC expression and tumorigenesis/transformation, it may represent one factor that contributes to the nonlinearity of their correlation.
Protocolized resuscitation with esophageal Doppler monitoring may improve outcome in post-cardiac surgery patients

Subjects: 174 adults who had cardiac surgery with cardiopulmonary bypass. Subjects undergoing off-pump surgery, aged 10 μg/kg/min of dopamine or dobutamine or >0.16 μg/kg/min of epinephrine or norepinephrine.