cssi/SciSciGPT-SciSciNet huggingface dataset:
Microstructure of copolymers formed by the reagentless, mechanochemical remodeling of homopolymers via pulsed ultrasound

The high shear forces generated during the pulsed ultrasound of dilute polymer solutions lead to large tensile forces that are focused near the center of the polymer chain, but quantitative experimental evidence regarding the force distribution is rare. Here, pulsed ultrasound of quantitatively geminal-dihalocyclopropanated (gDHC) polybutadiene provides insights into the distribution. Pulsed ultrasound leads to the mechanochemical ring-opening of the gDHC mechanophore to a 2,3-dihaloalkene. The alkene product is then degraded through ozonolysis to leave behind only those stretches of the polymer that have not experienced large enough forces to be activated. Microstructural and molecular weight analysis reveals that the activated and unactivated regions of the polymer are continuous, indicating a smooth and monotonic force distribution from the midchain peak toward the polymer ends. When coupled to chain scission, the net process constitutes the rapid, specific, and reagentless conversion of a single homop...
Investigation of Pre-Tungsten Silicide Deposition Wet Chemical Processing

Removing the native oxide from the poly-Si surface prior to WSix deposition is essential for achieving high quality silicides as well as sufficient film adhesion, particularly after high temperature anneal or oxidation. Contact angle studies have been used to determine initial and time-dependent surface characteristics of several types of silicon surfaces following immersions in HF-based etchants for varying amounts of time. The morphological characteristics of the surfaces before and after exposure to etchants, as well as the relative etch rates and wetting capabilities of the etchants have been used to explain the following results: With respect to initial contact angle studies, the implanted & annealed polycrystalline silicon surface has the lowest contact angle followed by polycrystalline and monocrystalline surfaces. Longer immersion times yield lower initial contact angles. The 0.1% lightly-buffered HF solution results in the highest contact angle followed by the 1% buffered HF solution with surfactant, and the 1% HF solution. With respect to contact angle changes during ambient air exposure time, the asdeposited polycrystalline silicon surface is most stable followed by monocrystalline, and implanted & annealed polycrystalline silicon surfaces. Longer immersion times improve surface stability while the 0.1% lightly-buffered HF solution results in the most stable surface followed by the 1% buffered HF solution with surfactant, and the 1% HF solution.
Implementation of a comprehensive competency-based transoral robotic surgery training curriculum with ex vivo dissection models

Background Despite its increasingly widespread adoption of transoral robotic surgery (TORS), there is still no uniform training curriculum. The purpose of this study was to describe the results of our novel TORS curriculum training program in which we introduce ex vivo dissection models for radical tonsillectomy and base of tongue (BOT) resections. Methods Prospective blinded data collection and objective assessment of a novel training curriculum. Trainee performance was evaluated on objective structured assessments of technical skills (OSATS) metrics, measured resection time, and margin analysis. Additionally, 4 expert TORS surgeons completed the ex vivo dissections. Results Trainees achieved OSATS scores similar to those of experts in both the BOT resection and radical tonsillectomy models. Peripheral and deep surgical margin measurements in the BOT model were significantly improved after training and were comparable to experts. Conclusion This graduated curriculum provides a realistic training experience to develop competency with oropharyngeal resections before transition to the operating room. © 2016 Wiley Periodicals, Inc. Head Neck, 2016
Research of College Students' Cultural Identity in Post-colonial Context

The cultural identity of college students' is a complicated question that is worth discussion,since it is closely related to national survival and development,national cultural independence and national dignity.This paper carried out a research aiming at finding out the cultural identity changes and the trend of cultural colonization among college English learners.The Chinese language learning,more Chinese characteristics in English textbooks and Critical Discourse Analysis in college English teaching can be the feasible ways to help college students construct their cultural identity.
Illustrating local community initiative in mental health reform: the management and treatment of depression by primary care physicians.

RIMARY CARE PHYSICIANS care for patients with mental health problems on a daily basis. Patients with psychiatric disorders (depression, anxiety, mixed disorders) are common in primary care settings with a prevalence of about 25 percent. 1 The prevalence of major depressive disorders for lifetime was recently reported at 16.2 percent and for 12-months was 6.6 percent. 2 Depression results in significant difficulty with home and job performances in the majority of patients. Multiple studies continue to demonstrate that primary care providers in outpatient settings underrecognize and undertreat patients with depression. 4 3 2 During my residency in the late 1970s, little emphasis was placed on mental health training for primary care physicians. It was expected that patients with these disorders would be cared for by the mental health profession, either by private psychiatrists, psychologists, clinical social workers, or the public mental health sector. This distinct separation generally continued into the 1980s, but in the 1990s patients increasingly had difficulty accessing mental health providers due to a reduction in behavioral mental health benefits and increased disarray of the public mental health system. 5 Thus, these patients complained about their poor mental health to primary care providers and requested care directed by/provided by their primary care physicians. What a challenge for primary care providers! In 1995 the local health coalition in Buncombe County, NC (population 200,000) known as HealthPartners, conducted a comprehensive community assessment that identified the county’s health care assets and needs. Only 29 percent of Buncombe County adults, who in the past year said that they had a major depressive episode, had ever accessed or tried to access mental health treatment. Low-income uninsured people were more likely to be depressed (40 percent) as compared to higher income, insured people (18 percent). 6 Based on this information and increasing concerns from physicians and patients, HealthPartners identified funds to design and implement a primary care-based depression program located at the Buncombe County Health Center, part of the county health department caring for 70 percent of our low-income uninsured. The program’s design was based on data supporting the benefit of screening and feedback to providers; integrated treatment guidelines; care managers who work with physicians to monitor care; and a supervising psychiatrist. 7 8 4
Physician usage of the computer to access a hospital information system.

This retrospective descriptive study was undertaken to determine the characteristics of physicians who use the computer to access a Hospital Information System (HIS). A convenience sample of 630 staff physicians at a 640-bed metropolitan tertiary care teaching medical center was analyzed utilizing the variables of age, specialty, years in practice, gender, and frequency of use. A significant difference (p < or = .01) in age was found with the user physician being younger than the nonuser; no significance was found (p < or = .01) in specialty, years in practice, or gender.
Feeling the Elephant: Some Observations on Agenda-Setting Research

(1988). Feeling the Elephant: Some Observations on Agenda-Setting Research. Annals of the International Communication Association: Vol. 11, Communication Yearbook 11, pp. 603-619.
Directing Discipline: State Medical Board Responsiveness to State Legislatures

State medical boards are increasingly responsible for regulating medical and osteopathic licensure and professional conduct in the United States. Yet, there is great variation in the extent to which such boards take disciplinary action against physicians, indicating that some boards are more zealous regulators than others. We look to the political roots of such variation and seek to answer a simple, yet important, question: are nominally apolitical state medical boards responsive to political preferences? To address this question, we use panel data on disciplinary actions across sixty-four state medical boards from 1993 through 2006 and control for over-time changes in board characteristics (e.g., composition, independence, budgetary status), regulatory structure, and resources. We show that as state legislatures become more liberal [conservative], state boards increasingly [decreasingly] discipline physicians, especially during unified government and in the presence of highly professional legislatures. Our conclusions join others in emphasizing the importance of state medical boards and the contingent nature of political control of state regulation. In addition, we emphasize the roles that oversight capacity and strategy play in offsetting concerns regarding self-regulation of a powerful organized interest.
Structured Intervention as a Tool to Shift Views of Parent-Professional Partnerships: Impact on Attitudes toward the IEP.

The Individualized Education Program (IEP) is the roadmap that helps educators and families drive the education of students with disabilities, improve outcomes, and fulfill each child’s potential. However, the IEP can be challenging due to the large number and diversity of stakeholders, dynamics and culture of collaboration, and the complex procedures guiding the referral, evaluation, and placement. This study describes changes in attitudes toward the IEP reported by special educators and parents participating in a statewide six-month collaborative training model. Pre- and post-test data analysis indicates an interaction effect on overall attitude toward the IEP, with parents’ ratings of the value of the IEP decreasing at the end of the training and teachers’ ratings increasing. Moreover, special educators’ significantly higher ratings of the value of team planning for the IEP indicate enduring pre- and post-intervention differences. These findings have implications for school districts and agencies providing professional development to improve collaboration in IEPs.
Educational Philosophies and Why They Matter

Berner contends that education cannot be neutral and that the uniform system imposes its own ethical claims upon schools. A school’s atmosphere and priorities, its traditions, the management of student discipline, the curriculum and how it is taught, the way adults relate to one another—all of these guide students’ experience with the world. Intentionally or tacitly, school practices draw upon deeper commitments and assumptions about human beings and what a life well lived looks like. The USA’s uniform school system has habituated us against seeing schools for the meaning-making institutions that they are. Berner argues that because education is morally rich and educational philosophies diverse and important, it is inappropriate (and intellectually dishonest) to enforce a uniform design.
Optically controlled microwave photonic dual-band filter with ultrafast reconfigurable capability

An ultrafast reconfigurable microwave photonic dual-band filter with four operation states is demonstrated. Through the control of optical pump power for nonlinear polarization rotation, gigahertz speed reconfiguration between different states is experimentally demonstrated.
High-specific-power electric machines for electrified transportation applications-technology options

Specific power of an electric machine is defined as the ratio of output power to total weight. High-specific-power (HSP) electric machines are in high demand in electrified transportation systems such as more electric aircraft (MEA) and electric vehicles (EV), because they help reduce the fuel consumption and extend the traveling range. However, electromagnetic, thermal, mechanical and manufacturing issues put limits on the machines' specific power and represent major technological challenges in their design and fabrication. This paper provides a survey of actual HSP machines and discusses design considerations and technology options for HSP machine development. An HSP permanent magnet synchronous machine architecture is proposed based on the survey and discussions.
A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells.

Fast, selective, and noninvasive reporting of intracellular cancer-associated events and species will lead to a better understanding of tumorigenesis at the molecular level and development of precision medicine approaches in oncology. Overexpressed reductase presence in solid tumor cells is key to cancer progression and protection of those diseased cells from the oxidative effects of therapeutics meant to kill them. Human NAD(P)H:quinone oxidoreductase isozyme I (hNQO1), a cytoprotective 2-electron-specific reductase found at unusually high activity levels in cancer cells of multiple origins, has attracted significant attention due to its major role in metastatic pathways and its link to low survival rates in patients, as well as its ability to effectively activate quinone-based, anticancer drugs. Accurate assessment of hNQO1 activities in living tumor models and ready differentiation of metastases from healthy tissue by fluorescent light-based protocols requires creation of hNQO1-responsive, near-infrare...
Calculating aluminum content in total parenteral nutrition admixtures.

The Food and Drug Administration (FDA) rule for limiting aluminum content in total parenteral nutrition (TPN) preparations continues to cause concerns among health care professionals, especially pharmacists.[1][1] The federal regulation applies to drug manufacturers and not pharmacy practitioners
CHAPTER 11 – Photodocumentation and Image Analysis

Photodocumentation refers to the investigator physically taking a picture of a gel soon after electrophoresis and staining. The newer digital technology systems for photodocumentation usually have an attached printer, thereby allowing the investigator to print a hard copy of the photograph. Using these systems, the image is digitized and a hard copy is generated either on heat-sensitive thermal paper, much like older style FAX paper, or on plain paper with a laser printer that helps in image analysis. All image analysis systems allow the user to set the amount of time that the shutter in the lens will be open for and the aperture setting. If one is uncertain as to the correct parameters, photographing ethidium bromide stained gels for 0.5 seconds at an aperture of f /8 is a good start, and corrections can be made as needed. Of course, the exact settings are empirically determined for each gel and are directly related to the mass of nucleic acid in the gel, the staining time, the destaining time (if any), the magnitude of background fluorescence, and whether epi-illumination or direct illumination from beneath the gel is used. Meaningful image analysis requires an understanding of the basic terminology and the benefits and deficiencies associated with this approach for analyzing gels and archiving data.
Vacuum impregnation of firming agents in red raspberries.

Red raspberries are a delicate and highly perishable fruit with a fragile pulp tissue. In this study we used vacuum impregnation (VI) methods to incorporate pectin and calcium chloride into whole red raspberries to improve their firmness. Specifically, we impregnated low methoxyl pectin (LMP) at 10 g of pectin kg-1 of solution and calcium chloride (CaCl2 ·2H2 O) at 30 g calcium kg-1 of pectin, and on the other side pectin methylesterase (PME) at 10 g of enzyme kg-1 of solution, and (CaCl2 ·2H2 O) at 10 g of calcium kg-1 of solution, into whole red raspberries. We tested three vacuum levels 33.9, 50.8, and 67.8 kPa, three vacuum impregnation times 2, 7, and 15 min, and two temperatures, 20 and 40 °C, during VI treatment. Maximum force (FM ) and gradient (GC3 ) were evaluated to assess raspberry firmness.; Results: A vacuum level of 50.8 kPa, processing time of 7 min, and a LMP and calcium infusion at 20 °C resulted in the firmest fruit compared to the other treatments. At these VI treatment conditions, FM and GC3 values of red raspberries obtained were 28 N, and 8.4 N mm-1 , respectively.; Conclusion: The optimal VI conditions identified in this study can be used to improve firmness and structural integrity of red raspberries by infusion of LMP and calcium. Findings on vacuum-impregnated red raspberries may be used to develop dehydrofrozen berries for incorporation into bakery and dairy products. © 2018 Society of Chemical Industry.; © 2018 Society of Chemical Industry.
The ribosome: A hot spot for the identification of new types of protein methyltransferases

Cellular physiology depends on the alteration of protein structures by covalent modification reactions. Using a combination of bioinformatic, genetic, biochemical, and mass spectrometric approaches, it has been possible to probe ribosomal proteins from the yeast Saccharomyces cerevisiae for post-translationally methylated amino acid residues and for the enzymes that catalyze these modifications. These efforts have resulted in the identification and characterization of the first protein histidine methyltransferase, the first N-terminal protein methyltransferase, two unusual types of protein arginine methyltransferases, and a new type of cysteine methylation. Two of these enzymes may modify their substrates during ribosomal assembly because the final methylated histidine and arginine residues are buried deep within the ribosome with contacts only with RNA. Two of these modifications occur broadly in eukaryotes, including humans, whereas the others demonstrate a more limited phylogenetic range. Analysis of strains where the methyltransferase genes are deleted has given insight into the physiological roles of these modifications. These reactions described here add diversity to the modifications that generate the typical methylated lysine and arginine residues previously described in histones and other proteins.
Benign hysterectomy performed by gynecologic oncologists: Is selection bias altering our ability to measure surgical quality?

Abstract Objective To compare the characteristics of women undergoing hysterectomy for benign disease with either a benign gynecologist or a gynecologic oncologist and to assess for differences in complication rates with and without risk adjustment. Methods Patients undergoing benign hysterectomy recorded in the National Surgical Quality Improvement Program (NSQIP) targeted hysterectomy file in 2015 were identified. The primary outcome was any postoperative complication. Stratified analysis was performed by route of surgery. Bivariable tests and modified Poisson regression were used to adjust for confounding by procedure type and patient characteristics. Results We identified 17,639 patients who underwent hysterectomy for benign pathology, primary surgeon was a benign gynecologist (82%) or gynecologic oncologist (18%). Patients who underwent surgery with gynecologic oncologists were older (51yo v 46yo), had a higher mean BMI (32 v 30), and a higher prevalence of prior abdominal surgery (29% v 25%, p Conclusions Patients operated on by gynecologic oncologists have a higher prevalence of risk factors for complication compared to those operated on by benign gynecologists even with a benign indication for surgery. Quality measurement should account for this selection bias.
The Flow Properties of Blood

Blood is a marvelous fluid that nurtures life, contains many enzymes and hormones, and transports oxygen and carbon dioxide between the lungs and the cells of the tissues. We can leave the study of most of these important functions of blood to hematologists, biochemists, and pathological chemists. For biomechanics the most important information we need is the constitutive equation.
An Overview of the Function, Composition and Structure of the Chloroplast ATP Synthase

A concise overview of the chloroplast ATP synthase is presented, with an emphasis on its functions, regulation, composition, and structure from fluorescence energy transfer mapping. The ATP synthase may be separated into two parts: coupling factor 1 (CF1) and CF0•CF1 is a large hydrophilic protein that contains the catalytic sites of the synthase. The functions of its five different polypeptides are briefly discussed. CF0 binds CF1 and functions to conduct protons across the thylakoid membrane. Because CF0 will not be considered in detail in subsequent chapters, the composition of CFα and some of its interactions with CF1 are discussed. Insights into the structure and function of CF1 as well as into subunit interactions, gleaned by structural mapping by fluorescence resonance energy transfer, are presented.
Event memory uniquely predicts memory for large-scale space

When a person explores a new environment, they begin to construct a spatial representation of it. Doing so is important for navigating and remaining oriented. How does one's ability to learn a new environment relate to one's ability to remember experiences in that environment? Here, 208 adults experienced a first-person videotaped route, and then completed a spatial map construction task. They also took tests of general cognitive abilities (working memory, laboratory episodic memory, processing speed, general knowledge) and of memory for familiar, everyday activities (event memory). Regression analyses revealed that event memory (memory for everyday events and their temporal structure), laboratory episodic memory (memory for words and pictures) and gender were unique predictors of spatial memory. These results implicate the processing of temporal structure and organization as an important cognitive ability in large-scale spatial-memory-from-route experience. Accounting for the temporal structure of people's experience while learning the layout of novel spaces may improve interventions for addressing navigation problems.
Dominant-negative NOX5 variant linked to primary immunodeficiency disorder

Several NOX enzymes have been linked to immunodeficiencies and inflammatory diseases. NOX5, a superoxide-generating NOX enzyme originally detected in the spleen, testes, and lymph nodes, is the least understood member of the NOX/DUOX family of NADPH oxidases, since the gene is absent in mice and rats, and no human diseases have been linked to NOX5. Using whole-exome sequencing of patients with immunodeficiencies, we identified an in-frame, three-codon deletion in NOX5. Here, we explored the functional consequences of this mono-allelic NOX5 variant (NOX5.P323_G325) on NADPH oxidase activity in reconstituted cell models. The alignment of this NOX5 sequence with other NOX isozymes shows that the 3-codon deletion occurs within the fourth transmembrane helix, between heme-binding helices 3 and 5. While predicted to be highly disruptive, western blotting for NOX5 detects an ~75 kDa band in both WT NOX5 and NOX5.P323_G325 transfected cells, with variant stability similar to WT NOX5. In comparison to WT NOX5-transfected cells, cells transfected with the NOX5.P323_G325 variant produced significantly less superoxide when stimulated with ionomycin, PMA, or H2O2 in all three cell models. Furthermore, the mutated protein causes dose-dependent inhibition of NADPH oxidase activity of co-expressed wild-type NOX5 in two NOX5-reconstituted models (COS-7 and HEK 293 cells), providing further insight on dominant-negative effects of this monoallelic gene variant. Taken together, our findings represent the first case in which a genetic and functional defect in NOX5 has been linked to immunodeficiency and raise the question of NOX5 involvement in lymphoid cell dysfunction.
Comparison of Xenogeneic Collagen Matrix vs. Free Gingival Grafts to Increase the Zone of Keratinized Mucosa Around Functioning Implants.

Purpose:To evaluate the effectiveness of collagen matrix (CM) grafts as an alternative to free gingival grafts (FGGs) in increasing the zone of keratinized tissue (KT) around dental implants.Methods:Thirty subjects with 2 contralateral implants were recruited. The test group (n = 30) received CM gra
Photonic Physical Unclonable Functions using Silicon Nitride Spiral Waveguides

Silicon nitride spiral physical unclonable functions provide unique spectral fingerprints in a compact, integrated platform and have potential for use in IC authentication.
Full disclosure: experimental analysis of female online dating on parole

Research has considered the effect of convictions on employment and housing outcomes, but there are limited studies exploring how criminal justice contact affects the initiation of relationships. This study uses an experimental design to explore how people react to criminal stigma in the context of online dating. Female online dating profiles were created using pre-rated, open access photographs of women that varied in race (Black, White, Latino). These three profiles comprised the control condition. The experimental condition consisted of the same exact three profiles with one exception: a brief mention of their being on parole in written profile bios. The three profiles attempted to match with 6000 online daters each in the control and experimental conditions across 18 online dating platforms (N = 36,000). Findings indicate that the Black and Latina profiles matched significantly less frequently when disclosing parole. In the parole disclosure condition, White female profiles received significantly more matches than Black and Latino profiles, and White females disclosing parole matched at a higher rate than White females not disclosing parole. The stigma of a criminal record is damaging for Blacks and Latinas who disclose parole in online dating bios, but for White females, disclosure of parole does not hinder and may even help their online dating match success. The stigma of being minority appears to compound criminal stigma in online dating. This has crucial implications for the relationships of formerly incarcerated because prosocial romantic relationships reduce recidivism.
Recurrent and de-novo autoimmune hemolytic anemia in patients treated with immunotherapy for advanced cancer.

e14170Background: Immunotherapy (IO) has brought dramatic clinical benefit to cancer patients. Serious immune-related adverse events (irAE) have been reported, however, hematological toxicities suc...
Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice.

We previously demonstrated protection against high fat-induced obesity in female but not male p47phox−/− mice lacking NADPH oxidase NOX1/2 activity. To test the role of estradiol (E2)-NOX crosstalk...
Milk donation after losing one's baby: Adopting a donor identity as a means of coping with loss

This is a study of bereaved mothers' donation of human milk to nonprofit human milk banks following their baby's death. Whereas much has been written about the biological and medical aspects of milk donations in times of loss, much less attention has been given to the psychosocial aspects of this phenomenon. I build on research of motivations for philanthropic giving in times of crisis and loss, and focus on the role of donor identity for explaining bereaved mothers' milk donations. Through a content analysis of 80 bereaved donors' personal testimonials, I demonstrate the role of a donor identity as a transformative identity in these women's process of coping with their loss. Taking on a temporary milk donor identity helped the women in this study reconstruct their shattered identities as mothers and healthy females and served to enfranchise them as bereaved mothers.
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis

Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to ﻿cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver were harvest for neutrophil infiltration, oxidative markers to lipids and protein and antioxidant activity of endogenous enzyme. Vitamin B6 diminished neutrophil infiltration in both organs, oxidative markers in the liver and restored catalase activity levels in the lung of septic animals. Vitamin B6 exerts anti-inflammatory and antioxidant effects in peripheral organs after polymicrobial sepsis.
4.402 – Biocompatibility and the Relationship to Standards: Meaning and Scope of Biomaterials Testing

This chapter presents biocompatibility (safety) evaluation of biomaterials, medical devices, and prostheses in the context of current standards and guidelines. The goal of this chapter is to provide an overview for the biological response evaluation, that is, biocompatibility evaluation, of end-stage ‘as-used’ medical devices, prostheses, and biomaterials. The chapter contains eight sections: biocompatibility; materials for medical devices; in vitro tests for biocompatibility; in vivo tests for biocompatibility; inflammation, wound healing, and the foreign body reaction; hemocompatibility; immune responses; and summary. It must be emphasized that standards, tests, and guidelines are constantly evolving and changing, and it can be anticipated that new information will provide new perspectives on immune response evaluation in the areas of tissue engineering and regenerative medicine.
Music therapy and retinopathy of prematurity screening: using recorded maternal singing and heartbeat for post exam recovery

Explore a music therapy (MT) intervention to support infant recovery post retinopathy of prematurity (ROP) exam. Prospective, double-masked, randomized, parallel group study of 100 preterm infants exposed to MT (recorded maternal singing/heartbeat) or standard care (SC). Premature Infant Pain Profile (PIPP) measured at: baseline, during the exam, and 1 and 5 min post exam. Recovery PIPP scores were less with MT vs. SC, but statistical significance not achieved (Mean ± sd: MT 1 min [5.81 ± 2.93] and 5 min [3.91 ± 1.73] vs. SC 1 min [6.40 ± 2.78] and 5 min [4.76 ± 2.07], p = 0.07). Recovery PIPP sores were significantly higher with SC compared to MT when eye exams were longer (p = 0.049) or when exams were more painful (p = 0.04). Recorded maternal singing and heartbeat can support recovery post ROP exam. For longer/more painful ROP exams, MT may be more effective than SC promoting recovery post exam.
At what age are English Premier League players at their most productive? A case study investigating the peak performance years of elite professional footballers

Seasonal statistics for 637 professional football players performing in the English Premier League (EPL) across 3 intermittent seasons were analysed via a series of Kruskal–Wallis tests in order to...
MODERN ASPECT OF UKRAINIAN POPULISM: POLITICAL AND SOCIAL ASPECT

The study of populism is actualized by the presence of a social order from interested political actors who use populism to implement their programs and in the struggle for power, focusing on the possibilities of change and reform. The relevance of the study is obvious given the lack of comprehensive study of populism in Ukraine, proper political evaluation of previous studies, rethinking some theses of individual researchers, and especially in connection with its actualization as one of the popular principles in action, behavior in modern political practice and our state. Today in Ukraine, the intensification and emergence of new manifestations of populism have become a sign of a general long-term failure on the path of technological modernization, in efforts to achieve rapid economic growth and in the fight against corruption. The tendency to the increasingly negative attitude of many citizens to complex and compromise procedures of democratic institutions, the desire for quick and simple solutions, intolerance of different views contain a double threat - to roll into anarchy or establish an authoritarian regime. Thus, populism can be considered an inevitable companion of political freedom and democracy. In some places, it is a force that promotes political participation and reform in the interests of many low-status social groups. By inclining to oppose the rights of the majority to the interests and rights of certain minorities, populism can be a threat to the rule of law and basic political and civil liberties. Wherever populist leaders gained power, it became authoritarian, accompanied by abuses and oppression (but not destruction) of the opposition.
The KAPA model of personality structure and dynamics

Abstract This chapter addresses the question of what are the enduring structures and dynamic processes of which personality is comprised. The KAPA model builds upon foundations in the extensive social-cognitive tradition in personality psychology and endeavors to advance beyond the concept that personality must be construed as a complex system whose elements are activated by features of the social world by specifying the elements of that system and how they causally contribute to specific patterns of personality coherence. The Kapa model provides theoretical and methodological tools that enable researchers to identify the content of the core aspects of self, and the associated life situations, at the level of the concrete individual case. The KAPA model aims to fill the gaps in 20th-century social-cognitive personality literature in three domains: (1) theory, (2) assessment, and (3) empirical research on cross-situational coherence in personality functioning.
Work-Care Balance over the Day and the Gender Wage Gap

We focus on the timing of labor supplied during the day and its interaction with home care responsibilities. Using the American Time Use Survey, we measure the incidence of household care activities between 8 AM and 5 PM (the prime time of the day). Women experience more work interruptions during that time. These work interruptions imply wages that are about 9 percent lower. This result is consistent with occupations offering more flexibility but also a lower wage. We offer suggestive evidence that missing work due to household demands has a larger penalty in occupations with more coordinated work schedules.
ATR Inhibitors and Paclitaxel in Melanoma.

A Phase 1 study defined a tolerable combination of the ATR inhibitor ceralasertib with paclitaxel and responses were seen in melanoma patients who had progressed on an immune checkpoint inhibitor. This combination warrants further exploration to determine the extent and molecular determinants of clinical activity.
Spinal Epidural Lipomatosis: A Comprehensive Review.

# Purpose of review This is a comprehensive review regarding the epidemiology, diagnosis, and management of spinal epidural lipomatosis (SEL). # Recent Findings SEL is a relatively rare condition that has gained scientific relevance over the past few decades. Recent findings include expanding treatment strategies to include minimally invasive surgical techniques. # Summary SEL is caused by an excess of adipose tissue accumulation localized to the thoracic and lumbar regions of the spine. While the exact pathogenesis is not fully elucidated, the etiology of SEL can be broadly classified based on five commonly associated risk factors; exogenous steroid use, obesity, endogenous steroid hormonal disease, spine surgery, and idiopathic disease. Progression of SEL may lead to neurological deficits, myelopathy, radiculopathy, neurogenic claudication, loss of sensation, difficulty voiding, lower extremity weakness, and rarely cauda equina syndrome. Conservative management is largely patient-specific and aimed at mitigating symptoms that arise from shared risk factors. If more advanced treatment measures are necessary, minimally invasive surgery and open surgical techniques, have proven successful.
Heightened splenic and bone marrow uptake of 18F-FDG PET/CT is associated with systemic inflammation and subclinical atherosclerosis by CCTA in psoriasis: An observational study.

Abstract Background and aims Psoriasis is an immune-mediated inflammatory disease with increased risk of myocardial infarction. Preclinical studies in psoriasis models show an association between chronic inflammation and immune cell proliferation in the spleen and bone marrow (BM). We sought to test the hypothesis that splenic and BM 18F-fluorodeoxyglucose (18F-FDG) uptake is heightened in psoriasis and that higher uptake associates with systemic inflammation and subclinical atherosclerotic disease measures in this cohort. Methods Multimodality imaging and biomarker assays were performed in 240 participants (210 with psoriasis and 30 healthy). Splenic and BM uptake was obtained using 18F-FDG positron emission tomography/computed tomography (PET/CT). Coronary artery plaque characteristics including non-calcified burden (NCB) and lipid rich necrotic core (LRNC) were quantified using a dedicated software for CT angiography. All analyses were performed with StataIC 16 (Stata Corp., College Station, TX, USA). Results Splenic and BM 18F-FDG uptake was increased in psoriasis (vs. healthy volunteers) and significantly associated with proatherogenic lipids, immune cells and systemic inflammation. Higher splenic 18F-FDG uptake associated with higher total coronary burden (β = 0.37; p Conclusions Heightened splenic and BM uptake of 18F-FDG is associated with proatherogenic lipids, immune cells, inflammatory markers and coronary artery disease. These findings provide insights into atherogenic mechanisms in psoriasis and suggest that immune cell proliferation in the spleen and BM is associated with subclinical atherosclerosis.
A solution of the integral equation h′(ƒ) = ∝μ′(ƒ;ƒ0) dz(ƒ0)

Abstract An alternative method for the solution of the integral equation h′(ƒ) = ∝μ′(ƒ;ƒ 0 ) dz (ƒ 0 ) is given. The solution involves expansion of the functions in a power series. It is believed that this solution is superior in some respects to previous methods. We will assume that there are no collisions.
Point-of-care ultrasound to identify distal ulnar artery thrombosis: Case of hypothenar hammer syndrome

Hypothenar hammer syndrome (HHS) is a rare condition of distal ulnar artery injury and thrombosis secondary to repetitive blunt trauma to the hypothenar area. We present a case of HHS for which point-of-care ultrasound (POCUS) was used as the initial means of imaging, prompting management and disposition without further imaging studies ordered in the emergency department (ED). This case demonstrates the utility of POCUS to aid the Emergency Physician in the diagnosis and management of patients with extremity vascular issues in the ED, and details a rarely seen clinical entity in the ED.
Happiness is drinking beer: a cross‐cultural analysis of multimodal metaphors in American and Ukrainian commercials

This paper examines multimodal conceptual metaphors in a corpus of 32 American and Ukrainian beer commercials. The dominant metaphor in both cultures is HAPPINESS IS DRINKING BEER, with a secondary metaphor BEER IS A PERSON. The Ukrainian commercials exhibit a third metaphor that appears in a very subtle way in the American commercials: LOVE FOR THE MOTHERLAND IS DRINKING BEER. The analysis reveals cross-cultural variation in the mappings and entailments of the metaphors. We argue that this variation is not just a matter of divergent advertising strategies but is a manifestation of differences in the conceptual understandings of happiness, beer drinking, friendship, and patriotism in both cultures. Este estudio investiga las metaforas conceptuales multimodales en un corpus de treinta y dos anuncios publicitarios de cerveza estadounidenses y ucranianas. La metafora principal en ambas culturas es LA FELICIDAD ES TOMAR CERVEZA, y una metafora secundaria es LA CERVEZA ES UNA PERSONA. Los comerciales ucranianos manifiestan una tercera metafora que aparece de una manera sutil en los comerciales estadounidenses: EL AMOR A LA PATRIA ES TOMAR CERVEZA. El analisis revela una variacion transcultural en las proyecciones e inferencias de las metaforas. Proponemos que esta variacion no solo se debe a estrategias de publicidad divergentes, sino que revela diferencias en la comprension conceptual de la felicidad, tomar cerveza, la amistad y el patriotismo entre las dos culturas.
PathwayMatrix: visualizing binary relationships between proteins in biological pathways

Background Molecular activation pathways are inherently complex, and understanding relations across many biochemical reactions and reaction types is difficult. Visualizing and analyzing a pathway is a challenge due to the network size and the diversity of relations between proteins and molecules.
Nietzsche on the Role of a Bearer of Culture (Kulturträger) in Modern Democracies

My paper argues, through an interpretation of Nietzsche’s philosophy, that the power of culture to enhance the political capacities of collectivities, thus working as a corrective to the internally and externally aggressive ideologies of the modern state, such as nationalism, resides in the manner in which individuals use their imagination and language. Since the analogical capacity of the aesthetic drive is the source of particular cultural horizons, one task of a democratic bearer of culture is to equally cultivate the explorative power of imagination. Since the origin of language is metaphorical and rhetorical, the other task of a democratic bearer of culture is to keep the memory of the primary orientation of words and language toward addressing and persuading the others vivid. Only thus the modern retreat into one’s internal realm and “into the smallest egoistic region,” which blinds people to anything else besides their own advantage or party, would be avoided.
NON-UNIFORM WEALTH DISTRIBUTION IN A SIMPLE SPATIAL BANKING MODEL

Submitted December 2005; accepted January 2007This paper uses a static spatial banking model with a non-uniform wealth distribution toprovide theoretical assessments for differences in banks’ prices and locations across regions. Itassumes imperfect information, where banks know more about individuals if they are “near”the bank and individuals incur in a cost proportional to this distance to show the viability oftheir projects to the bank. A free entry model is constructed to account for banks’ tendency toconcentrate in rich regions and to charge lower prices. Comparative statics exercises show theeffect of changes in the monitoring technology and wealth dispersion.JEL classification codes: G21, L11Key words: spatial banking, location
The properties of rabbit muscle glyceraldehyde 3-phosphate dehydrogenase labeled with a "reporter group".

Abstract A "reporter group," 2-acetamide-4-nitrophenol, has been incorporated at the active site sulfhydryl group of each of the four subunits of rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. Changes in the spectrum of this group are produced by changes in pH, addition of DPN and DPNH, or addition of adenosine derivatives including adenosine diphosphoribose, ATP, AMP, and cyclic AMP. Below pH 7.8 the environment of the reporter group is apparently more polar than water while at higher pH there is a shift of the group to a less polar environment. This pH-dependent transition is consistent with the removal of a proton from a neighboring ionized residue with a pK of about 8.5 and is qualitatively similar to the effects observed with reporter-labeled chymotrypsin. Binding of DPN or DPNH also produces a shift of the reporter group to a nonpolar environment, although the changes are different for the two compounds. The alterations in Kdis, subunit interactions, and spectral properties of the reporter-labeled enzyme suggest that the perturbation of the reporter group is due to changes in conformation of the enzyme. The other adenosine compounds are also shown to bind to the enzyme and produce a shift in the spectrum of the reporter group. ATP is unique in that it is tightly bound to two sites on the enzyme but does not compete effectively with DPN. The properties of the reporter-labeled enzyme appear to correspond to those of the normal acyl enzyme intermediate and thus it provides a useful tool for studying the properties of this intermediate.
Sinusoidal current rectification and ripple cancellation in a very wide three phase AC input to generate a regulated DC output

This paper represents a three-phase AC to DC rectifier topology that produces a regulated DC output voltage with low input current distortion. The novelty of this paper lies in the circuit which not only operates over a wide range of input voltages but also provides ripple cancellation in the rectifier current. Moreover, this power converter utilizes the principle of third harmonic current generation and circulation through a zig-zag transformer in order to achieve power factor correction in the line current. Since simulation is a way to investigate the concept prior to any hardware realization, PSpice-based simulation has been carried out. Simulation results are presented that prove the concept.
Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast.

The ESCRT-0 and ESCRT-I complexes coordinate the clustering of ubiquitinated cargo with intralumenal budding of the endosomal membrane, two essential steps in vacuolar/lysosomal protein sorting from yeast to humans. The 1.85-A crystal structure of interacting regions of the yeast ESCRT-0 and ESCRT-I complexes reveals that PSDP motifs of the Vps27 ESCRT-0 subunit bind to a novel electropositive N-terminal site on the UEV domain of the ESCRT-I subunit Vps23 centred on Trp16. This novel site is completely different from the C-terminal part of the human UEV domain that binds to P(S/T)AP motifs of human ESCRT-0 and HIV-1 Gag. Disruption of the novel PSDP-binding site eliminates the interaction in vitro and blocks enrichment of Vps23 in endosome-related class E compartments in yeast cells. However, this site is non-essential for sorting of the ESCRT cargo Cps1. Taken together, these results show how a conserved motif/domain pair can evolve to use strikingly different binding modes in different organisms.
Behavior in Hydra: Contraction Responses of Hydra pirardi to Mechanical and Light Stimuli

Hydra pirardi contracts in response to light and mechanical agitation. The animals show a reduction in the number of contractions in response to mechanical agitation on repeated testing but continue to contract in response to a light stimulus. Excision of all the tentacles of the animal completely inhibits contraction in response to mechanical agitation but does not affect contraction in response to light. The results of these experiments suggest that H. pirardi has different receptors for light and for mechanical agitation and that the control mechanisms for the contraction responses to these two stimuli are independent.