cssi/SciSciGPT-SciSciNet huggingface dataset:
Relevance of Competency-based Education to Work with Individuals with Serious Mental Illness

Individuals with serious mental illness (SMI) experience impairment in personal, social, and occupational domains of functioning. They interact with several systems to fulfill their day-to-day functioning. This paper reviews literature to identify systems with which the SMI population interacts with and highlights the ways those systems help or deter their functioning in society. The new Council on Social Work Education (CSWE) Educational Policy and Accreditation Standards (EPAS) requires competency-based curriculum to educate social workers on how best to serve hard-to-reach populations. This article includes four competencies essential in educating social workers to work with the SMI population. Finally, there is a discussion of the ways that the CSWE's new accreditation standards for social work can be incorporated in a curriculum that focuses on understanding the experiences and needs of individuals with SMI.
On the Stability of Nearly Parallel Vortex Filaments

In these lectures we shall concentrate on some topics on the theory of incompressible fluids. In particular, we shall discuss the vorticity equations in 2D and 3D, the dynamic of point vertices, the bi-normal equation (modeling the motion of a self-interaction vortex filament), and the system for the interaction of nearly parallel vortex filaments deduced by Klein, Majda and Damodaran. We explain some of the results obtained by Kenig, Ponce and Vega concerning the existence of explicit solutions for this system as well as the stability of somespecial configurations.
Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism.

Coagulopathy Does Not Fully Protect Hospitalized Cirrhosis Patients from Peripheral Venous Thromboembolism
Links between effective tensors for fiber-reinforced elastic composites

Abstract Predicting the effective elasticity of a composite material based on the elasticity of the constituent materials is extremely difficult, even when the microstructure is known. In this paper we consider a link between effective elastic tensors of composites with the same microgeometry but different constituent materials. Information about the effective tensor of one composite can then be used to determine the other. The general theory of exact relations allows us to identify all such links in principle. Here we describe a special set of links, for which one of the composites can be chosen arbitrarily. Several applications are considered and a number of microstructure-independent relations satisfied by the effective elastic tensors is derived.
Data Collection Effects on Nonmetric Multidimensional Scaling Solutions

This study investigates four widely used methods of collecting direct similarity judgments for nonmetric multidimensional scaling: Rating Scale, Triads, Rank Order of Pairs, and Conditional Rank Order. The results indicate that: (1) when class structure is very striking in the attributes to be scaled, respondents under the Rating Scale method place significantly more weight on class structure than on continuously varying attributes in determining similarity; (2) nonmetric multidimensional scaling solutions account for a greater proportion of the variance in Rank Order of Pairs data than in data collected by the other methods studied, although the differences are so small that they would have little operational impact; and (3) the four methods do not differ significantly in test-retest reliability.
The tandem Bergman-radical cyclization : a new method for ring annulation

Abstract Heading of enediynes 1a, 1b and 2 at 210° C in a sealed tube in the presence of a hydrogen atom source yields naphthalene derivatives 3a, 3b and 4 in yields of 53-72%.
Partitioning Arrangements of Lines: II. Applications

In this paper we present efficient deterministic algorithms for various problems involving lines or segments in the plane, using the partitioning algorithm described in a companion paper [A3]. These applications include: (i) anO(m2/3n2/3 · log2/3n · log?/3 (m/?n)+(m+n) logn) algorithm to compute all incidences betweenm points andn lines, where ? is a constant <3.33; (ii) anO(m2/3n2/3 · log5/3n · log?/3 (m/?n)+(m+n) logn) algorithm to computem faces in an arrangement ofn lines; (iii) anO(n4/3 log(?+2)/3n) algorithm to count the number of intersections in a set ofn segments; (iv) anO(n4/3 log(? + 2)/3n) algorithm to count "red-blue" intersections between two sets of segments, and (v) anO(n3/2 log?/3n) algorithm to compute spanning trees with low stabbing number for a set ofn points. We also present an algorithm that, given set ofn points in the plane, preprocesses it, in timeO(n?m log?+1/2n), into a data structure of sizeO(m) forn logn≤m≤n2, so that the number of points ofS lying inside a query triangle can be computed inO((n/?m) log3/2n) time.
Sense of Community and Neighbourhood Form: An Assessment of the Social Doctrine of New Urbanism:

New urbanism, an umbrella term which encompasses 'neotraditional development' as well as 'traditional neighbourhood design', lives by an unswerving belief in the ability of the built environment to...
Thermodynamically important contacts in folding of model proteins.

Proteins are heteropolymers, composed of 20 types of amino acids, that perform specific functions. The amino acid composition of proteins determines their unique structure, function, and folding kinetics. Understanding the relevance of the interactions between amino acids to protein folding is a complex task that has been the subject of a number of theoretical and experimental studies @1‐13#. The transition from the unfolded to the folded state of a protein is accompanied by a drastic reduction of the entropy. In one popular scenario, the folding transition for short proteins is analogous to the nucleation process at a first-order transition @2,6,8,12#, with competition between two free-energy minima: the folded state with low energy and entropy and the unfolded state with high energy and entropy. These two minima are separated by a free-energy barrier corresponding to the transition states. At the folding transition temperature T f , there is an abrupt change in the energy of the system resulting in a pronounced peak in the specific heat. AtT f , a small increase in interaction energy e ij between amino acids i and j ‘‘contact strength’’ results in rapid transition to the folding state, while a small decrease in contact strength results in transition to the unfolded state. Temperature is measured in units of kB/e @10#. However, different amino acids have a different contribution to the folding transition. Small variation in e ij for different pairs i and j has a different effect on the folding transition. Here, we study the thermodynamic importance of each interaction during folding by computing the entropic susceptibility—the response function to a small perturbation of e ij . We assume that the protein potential energy is additive in the pair potentials ~contacts!
Case studies of corrosion of mixed waste and transuranic waste drums

This paper presents three case studies of corrosion of waste drums at the Los Alamos National Laboratory (LANL). Corrosion was not anticipated by the waste generators, but occurred because of subtle chemical or physical mechanisms. In one case, drums of a cemented transuranic (TRU) sludge experienced general and pitting corrosion. In the second instance, a chemical from a commercial paint stripper migrated from its primary containment drums to chemically attack overpack drums made of mild carbon steel. In the third case, drums of mixed low level waste (MLLW) soil corroded drum packaging even though the waste appeared to be dry when it was placed in the drums. These case studies are jointly discussed as ``lessons learned`` to enhance awareness of subtle mechanisms that can contribute to the corrosion of radioactive waste drums during interim storage.
Presumed Consent, Autonomy, and Organ Donation

I argue that a policy of presumed consent for cadaveric organ procurement, which assumes that people do want to donate their organs for transplantation after their death, would be a moral improvement over the current American system, which assumes that people do not want to donate their organs. I address what I take to be the most important objection to presumed consent. The objection is that if we implement presumed consent we will end up removing organs from the bodies of people who did not want their organs removed, and that this situation is morally unacceptable because it violates the principle of respect for autonomy that underlies our concept of informed consent. I argue that while removing organs from the bodies of people who did not want them removed is unfortunate, it is morally no worse that not removing organs from the bodies of people who did want them removed, and that a policy of presumed consent will produce fewer of these unfortunate results than the current system.
A functional model of the mammalian circadian pacemaker

This paper describes a general model of the mammalian circadian pacemaker with specific parameters for golden hamsters. The model successfully simulates free-runs in constant darkness and constant light, phase shifts induced by light pulses and entrainment and relative coordination under light-dark cycles. It also accounts for the recent findings that the amplitude of the phase response curve to light pulses is dependent on the free-running period of the animal and on the previous history of photic stimulation. Effects of non-photic stimuli on the circadian pacemaker are discussed.
The maximum difference between the binomial and Poisson distributions

Abstract Explicit expressions are given for the maximum error between the binomial distribution with parameters n and p and its Poisson approximants, for sufficiently small values of np. Both the error in the cumulative distribution function and that in the probability mass function are given for Poisson approximants having means λ = np and λ = −n log(1 − p).
Determination of the water geometry in violuric acid monohydrate with a Monte Carlo simulation

The positions and orientations of water molecules in violuric acid crystals have been determined with the Metropolis Monte Carlo method. The interaction potentials between water and violuric acid needed in the simulation have been developed using ab initio calculations corrected for the basis set superposition error with the C.P. technique and fitted to atom-atom pairwise potentials. The agreement between experimental data and simulation results is good, proving that the interaction potentials can be used with confidence.
A Wireless and Batteryless 10-Bit Implantable Blood Pressure Sensing Microsystem With Adaptive RF Powering for Real-Time Laboratory Mice Monitoring

An implantable real-time blood pressure monitoring microsystem for laboratory mice has been demonstrated. The system achieves a 10-bit blood pressure sensing resolution and can wirelessly transmit the pressure information to an external unit. The implantable device is operated in a batteryless manner, powered by an external RF power source. The received RF power level can be sensed and wirelessly transmitted along with blood pressure signal for feedback control of the external RF power. The microsystem employs an instrumented silicone cuff, wrapped around a blood vessel with a diameter of approximately 200 ?m, for blood pressure monitoring. The cuff is filled by low-viscosity silicone oil with an immersed MEMS capacitive pressure sensor and integrated electronic system to detect a down-scaled vessel blood pressure waveform with a scaling factor of approximately 0.1. The integrated electronic system, consisting of a capacitance-to-voltage converter, an 11-bit ADC, an adaptive RF powering system, an oscillator-based 433 MHz FSK transmitter and digital control circuitry, is fabricated in a 1.5 ?m CMOS process and dissipates a power of 300 ?W. The packaged microsystem weighs 130 milligram and achieves a capacitive sensing resolution of 75 aF over 1 kHz bandwidth, equivalent to a pressure sensing resolution of 1 mmHg inside an animal vessel, with a dynamic range of 60 dB. Untethered laboratory animal in vivo evaluation demonstrates that the microsystem can capture real-time blood pressure information with a high fidelity under an adaptive RF powering and wireless data telemetry condition.
Stability of Ensembles of Ge/Si(100) Islands

We have investigated the stability of ensembles of Ge/Si(100) islands by annealing at their growth temperature. Islands grown by molecular beam epitaxy at temperatures of 450, 550, 600 and 650°C were annealed for times between 5 and 120 minutes. Small, pure Ge hut clusters, bound by {105} facets appear to be extremely stable structures, surviving the longest anneals with no apparent coarsening. Dome clusters, however, coarsen. Large alloyed hut clusters, apparent in as-grown samples only for growth temperatures greater than 600°C, appear during annealing at 450 and 550°C. During anneals at 550 and 650°C, we observe novel coarsening behavior. Arrays of crystallographically oriented, alloyed hut clusters are formed which result from the dissolution of large, alloyed dome clusters.
Janus kinases in immune cell signaling.

The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They are involved in cell growth, survival, development, and differentiation of a variety of cells but are critically important for immune cells and hematopoietic cells. Data from experimental mice and clinical observations have unraveled multiple signaling events mediated by Jak in innate and adaptive immunity. Deficiency of Jak3 or Tyk2 results in defined clinical disorders, which are also evident in mouse models. A striking phenotype associated with inactivating Jak3 mutations is severe combined immunodeficiency syndrome, whereas mutation of Tyk2 results in another primary immunodeficiency termed autosomal recessive hyperimmunoglobulin E syndrome. In contrast, complete deletion of Jak1 or Jak2 in the mouse are not compatible with life and, unsurprisingly, do not have counterparts in human disease. However, activating mutations of each of the Jaks are found in association with malignant transformation, the most common being gain-of-function mutations of Jak2 in polycythemia vera and other myeloproliferative disorders. Our existing knowledge on Jak signaling pathways and fundamental work on their biochemical structure and intracellular interactions allow us to develop new strategies for controlling autoimmune diseases or malignancies by developing selective Jak inhibitors, which are now coming into clinical use. Despite the fact that Jaks were discovered only a little more than a decade ago, at the time of writing there are 20 clinical trials underway testing the safety and efficacy of Jak inhibitors.
Comparison of three enzyme-linked immunosorbent assays to detect Porcine circovirus-2 (PCV-2)-specific antibodies after vaccination or inoculation of pigs with distinct PCV-1 or PCV-2 isolates

Porcine circovirus-2 (PCV-2) serology is frequently used to determine PCV-2 status and optimal timing of PCV-2 vaccination in the field. The objectives of the current study are to determine the diagnostic accuracy of 3 currently available commercial anti-immunoglobulin G (IgG) PCV-2 enzyme-linked immunosorbent assays (ELISAs) and to compare the ability of the 3 assays to detect and differentiate between anti-PCV-2a and anti-PCV-2b antibodies, as well as anti-PCV-2 and anti-PCV-1 antibodies. Fifty- five 3-week-old, conventional pigs were randomly allocated to 7 groups: 1) negative controls (n 5 7), 2) PCV- 2a (n 5 8; inoculated with PCV-2 ISU-40895), 3) PCV-2b (n 5 8; inoculated with PCV-2 NC-16845), 4) PCV-1 (n 5 8), 5) vaccine A (n 5 8; IngelvacH CircoFLEX TM ), 6) vaccine B (n 5 8; CircumventH PCV2), and 7) vaccine C (n 5 8; SuvaxynH PCV2 One Dose). Blood samples were collected weekly, and all sera were tested by 3 different anti-PCV-2 IgG ELISAs. The results indicated that all ELISAs had area under the receiver operating curve values greater than 0.94, detected both anti-PCV-2a and -2b antibodies with no differentiation, and did not detect anti-PCV-1 antibodies in infected animals. One of the ELISAs was able to distinguish pigs vaccinated with vaccine B from pigs inoculated with either PCV-2a or PCV-2b.
Cell Surface Heparan Sulfate Promotes Replication of Toxoplasma gondii

Previous work suggests that cell surface heparan sulfate acts as a receptor for the Apicomplexan parasite Toxoplasma gondii. Using Chinese hamster ovary cell mutants defective in heparan sulfate biosynthesis, we show that heparan sulfate is necessary and sufficient for infectivity. Further, we demonstrate that the parasite requires N sulfation of heparan sulfate initiated by N-deacetylase/N-sulfotransferase-1, but 2-O sulfation and 6-O sulfation appear to be dispensable. In order to study the role of heparan sulfate in other cell types, we created a conditional allele for N-deacetylase/N-sulfotransferase-1 by using Cre-loxP technology. Mammary tumor cells lacking N-deacetylase/N-sulfotransferase-1 exhibited reduced toxoplasma infectivity like Chinese hamster ovary cell mutants. Surprisingly, heparin, chemically modified heparinoids, and monoclonal antibodies to heparan sulfate had no effect on toxoplasma infection. T. gondii attachment and invasion were unchanged in N-deacetylase/N-sulfotransferase-1-inactivated cells as well, but replication was reduced. Thus, heparan sulfate does not appear to function as a receptor for T. gondii but instead facilitates parasite replication postinvasion.
College Of Business Majors" Perceptions Toward Globalization: An Empirical Study

The objective of this paper is to determine the extent to which business majors’ attitudes towards globalization are influenced by the area of selected study. Research has documented that more favorable attitudes towards globalization are found among college students, and specifically, these more favorable attitudes are found in business majors. While individuals may see globalization resulting in positive effects for the economy, business and the consumer, attitudes concerning globalization’s impact on the environment and domestic job creation and security may be quite different. We surveyed junior and senior students at a mid-western public university on a variety of questions related to globalization. Unlike the comparison of business with liberal arts majors, a further examination of the responses of four different business majors failed to note any consistent differences in the student responses. Our findings support the Heckscher-Ohlin theory which argues that one’s skill endowments influence perceptions on globalization, and, when applied to the academic environment, the more favorable global attitudes among business majors are influenced by the skills attained in their academic training.
Professional Development of Secondary Science Teachers of English Learners in Immigrant Communities.

This is a research study of secondary science teacher professional development, in which 30 teachers learned about and implemented a series of teaching strategies aimed at increasing the participation and learning of English Learners in schools serving largely Latino immigrant communities within California’s Central Valley. This study focuses on six of the 30 science teachers. Through a professional summer development workshop, teachers were exposed to science content that included the use of pedagogical strategies that intended to improve knowledge acquisition for students in immigrant communities. The pedagogical approach used for enhancing teacher skills was the 5E model. The methodology used to examine the pedagogical approach was qualitative teacher observations. Results indicate that all 6 teachers and their students increased engagement and explanation abilities, and students had opportunities to explore and elaborate their understanding of science content when teachers implemented the 5E model.
Poststerilization regret: findings from the United States Collaborative Review of Sterilization.

Abstract Objective: To evaluate the cumulative probability of regret after tubal sterilization, and to identify risk factors for regret that are identifiable before sterilization. Methods: We used a prospective, multicenter cohort study to evaluate the cumulative probability of regret within 14 years after tubal sterilization. Participants included 11,232 women aged 18–44 years who had tubal sterilizations between 1978 and 1987. Actuarial life tables and Cox proportional hazards models were used to identify those groups at greatest risk of experiencing regret. Results: The cumulative probability of expressing regret during a follow-up interview within 14 years after tubal sterilization was 20.3% for women aged 30 or younger at the time of sterilization and 5.9% for women over age 30 at sterilization (adjusted relative risk [RR] 1.9; 95% confidence interval [CI] 1.6, 2.3). For the former group, the cumulative probability of regret was similar for women sterilized during the postpartum period (after cesarean, 20.3%, 95% CI 14.5, 26.0; after vaginal delivery, 23.7%, 95% CI 17.6, 29.8) and for women sterilized within 1 year after the birth of their youngest child (22.3%, 95% CI 16.4, 28.2). For women aged 30 or younger at sterilization, the cumulative probability of regret decreased as time since the birth of the youngest child increased (2–3 years, 16.2%, 95% CI 11.4, 21.0; 4–7 years, 11.3%, 95% CI 7.8, 14.8; 8 or more years, 8.3%, 95% CI 5.1, 11.4) and was lowest among women who had no previous births (6.3%, 95% CI 3.1, 9.4). Conclusion: Although most women expressed no regret after tubal sterilization, women 30 years of age and younger at the time of sterilization had an increased probability of expressing regret during follow-up interviews within 14 years after the procedure. (Obstet Gynecol 1999;93:889–95.)
On the all-to-all broadcast problem in optical networks

This paper considers the transmission of uniform deterministic traffic in an optical broadcast-star network using wavelength division multiplexing. Lower bounds are established on the minimum time to exchange information between every node pair in such a network with tunable transmitters and fixed-tuned receivers. Three different scheduling algorithms are developed that are strictly optimal in three regimes of system parameters. The results are applicable to arbitrary tuning delays and arbitrary numbers of wavelength channels, and indicate the existence of a well-defined transition regime from tuning-limited operation to bandwidth-limited operation.
Radio-Frequency Transistors Using Chemical-Vapor-Deposited Monolayer Graphene: Performance, Doping, and Transport Effects

Large-area graphene is synthesized by Cu-catalyzed chemical vapor deposition (CVD), transistors are constructed, and the dc/RF performance is examined. Top-gate transistors, i.e., with a gate length of 3 μm and Vds = 5 V, have a peak dc transconductance in excess of 20 mS/mm and a drive current of 0.5 A/mm. RF measurements achieve gigahertz extrinsic current-gain cutoff frequency with low back biasing. Back-gated devices are used to examine doping and transport effects that impact the performance. Good agreement between measurements and a drift-diffusion model is obtained for gapless graphene with a net p-type doping and asymmetric electron/hole mobility. The mean free path for scattering is extracted and reveals that the transport suffers from large levels of Coulomb scattering and short-range scattering. The results are of importance for understanding the performance potential of large-area CVD graphene in future RF devices.
Avian Use of Successional Cottonwood (Populus deltoides) Woodlands Along the Middle Missouri River

Cottonwood (Populus deltoides) woodlands are important habitats for birds. Yet, little is known of the relations between bird habitat and succession in these woodlands. We studied the bird community in cottonwood woodlands from early to late seral stages along the Missouri River in central South Dakota from 1990 to 1992 to describe quantitative relations between avifauna and ecological patterns of succession in cottonwood woodlands along the Missouri River. The vegetation in the early seral cottonwood was characterized by a high density of seedlings and saplings that were restricted to narrow bands along the rivers. Late seral cottonwoods were characterized by a few large old trees that extended across the flood plain. Seventy-nine percent of the bird species were woodland obligates. Birds that nest in trees or cavities were the most common, while shrub and ground nesting birds were relatively uncommon. Total bird abundance, species diversity, species richness, richness of woodland obligates, abundance in the tree-nesting guild, abundance in the cavity-nesting guild and abundance in the shrub-nesting guild were greater (P 0.10) in early or early intermediate seral cottonwood. Bell's vireos (Vireo belli), indigo buntings (Passerina cyanea) and brown thrashers (Toxostoma rufum) occurred predominantly in early or early intermediate seral stages, but no significant differences among seral stages were noted. Expanses of late seral cottonwood on flood plains will likely decline because controlled river flows reduce flooding that is necessary for cottonwood regeneration. Cottonwood regeneration was evident only in narrow bands along the river channels. Cavity nesting species will be the most negatively affected by loss of late seral cottonwood.
A family of range restricted iterative methods for linear discrete ill-posed problems

The solution of large linear systems of equations with a matrix of ill-determined rank and an errorcontaminated right-hand side requires the use of specially designed iterative methods in order to avoid severe error propagation. The choice of solution subspace is important for the quality of the computed approximate solution, because this solution typically is determined in a subspace of fairly small dimension. This paper presents a family of range restricted minimal residual iterative methods that modify the well-known GMRES method by allowing other initial vectors for the solution subspace. A comparison of the iterates computed by different range restricted minimal residual methods can be helpful for determining which iterates may provide accurate approximations of the desired solution. Numerical examples illustrate the competitiveness of the new methods and how iterates from different methods can be compared.
Networked Solidarity: An Exploratory Network Perspective on Twitter Activity Related to #illridewithyou

This study examines the nature of issue-based Twitter response networks using the hashtag "#illridewithyou. This hashtag was a response of solidarity towards Muslims in Australia after a hostage incident that occurred in Sydney in December 2014. A network of 11293 users that used the hashtag #illridewithyou and their tweets were analyzed to examine the nature of engagement at network, ego, and semantic levels. Results show that although the #illridewithyou network has some characteristics of scale free networks, including a high clustering coefficient, low mean geodesic distance, and degree distribution approximating the power law, it lacks a giant connected component, but rather is structured into local clusters. Citizen participation, as indicated by out-degree, was considerably high in the network, and the topics discussed in the Tweets ranged from religion and empathy to globalism, multiculturalism and peace. Participants are globally connected but active in small clusters.
The Effects of a Manual Furniture Handling Device on Muscle Activity and Kinematics of the Lower Back

Low back disorders (LBDs) are prevalent in the manual furniture moving industry. However, few practical lifting aids are available, especially when handling objects requiring two movers. A belt system, the GRIPSystem™, has been developed to assist movers who operate in pairs while lifting awkward furniture. The purpose of this study is to evaluate the effectiveness of this manual device in reducing key low back disorders risk factors. Twelve subjects (9 male and 3 female) were recruited to participate in this study. The subjects lifted three household furniture items, at three varied weights, with and without the lifting device, while trunk kinematics and 10 muscle EMG signals were recorded. The results showed that the device significantly lowered the kinematics and muscle activity of the lower back, as well as the risk of LBDs. Other potential benefits of the device are also discussed. However, further studies are needed to confirm the device's effectiveness in reducing LBDs in the moving industry.
Electric Propulsion Plume Modeling Using Parallel Supercomputers

A parallel, three-dimensional electrostatic PIC code is developed for large-scale simulations of ion thruster plume spacecraft interactions on parallel supercomputers. This code is based on a newly developed immersed-flnite-element (IFE) PIC. The IFE-PIC is designed to handle complex boundary conditions accurately while maintaining the computational speed of the standard PIC code. Domain decomposition is used in both fleld solve and particle push to divide the computation among processors. A high-resolution simulation of multiple ion thruster plume interactions for a realistic spacecraft using a domain enclosing the entire solar array panel is carried out to demonstrate the capability of the code. A standard flnite difierence PIC (FD-PIC) code is also parallelized for comparison. Both the IFE-PIC and FD-PIC run with similar overall speed and the IFE-PIC achieves a high parallel e‐ciency of ‚ 90%.
Turbulence and tranquility in the new decade: pharmacy leader--managers in patient care

Management challenges that face pharmacy in the 1990s are described. Tichy's rope metaphor--intertwined cultural, technical, and political strands of an organization--is applied to problems faced by pharmacy managers; effective managers keep the organization strong by preventing the strands from working at cross-purposes to unravel the rope. Pharmacy's culture--its shared beliefs and values--is changing as "altruistic" institutional pharmacists form home care businesses, pharmacists identify more strongly with the profession than with their institutions, clinical pharmacists identify more strongly with the medical team, and cost control becomes more important. Institutional pharmacy must identify its desired outcomes and apply technology to achieve them. The patient's bedside is the best place for pharmacists to influence prescribing and monitor drug therapy; technology could be used to process patient information at the bedside and to dispense medications there. Current unit dose distribution systems isolate the functions of physician, pharmacist, and nurse, which must be integrated to make the system efficient and responsive. Standardized doses and dosage forms could be developed that are consistent with patient-care protocols; use of protocols allows the effectiveness of treatment methods to be evaluated and eliminates unnecessary therapy. Pharmacy can further its patient-care goals through political success with the medical staff; a pharmacy practice plan developed for a specific clinical area and presented to the medical staff is an example. Collaboration of pharmacists and physicians in a unified institutional strategy for drug use helps ensure appropriate decisions about therapy and prevents manufacturers from attempting to isolate an institution's pharmacists from its medical staff.(ABSTRACT TRUNCATED AT 250 WORDS)
Migration, imagination, poétique. Le paradigme transnational chez Marie-Célie Agnant

Le present article analyse La Dot de Sara et Le Livre d’Emma, de l’ecrivaine haitienne-quebecoise Marie-Celie Agnant, sous l’angle du transnationalisme, notion empruntee aux sciences sociales. Il s’agit de demontrer que le paradigme transnational y est plus qu’un simple enjeu thematique et diegetique, car il se manifeste dans la structure, la narration et la langue des deux romans. La tension entre pays d’origine et pays d’accueil, fiction et monde referentiel, experience individuelle et collective, hors-texte et texte faconne une poetique portee par la geographie migratoire dont sont marques les personnages et l’auteure.
Retirement Security: It's Not Just About the Money

Retirement security is not just about the money. Although there are many guidelines for financial security, there are few for crafting a rewarding life in the new era of longevity and health. With the meaning of "retirement" being actively redefined, there is a gap between what older adults want and need and what their employers and policymakers are offering. Retirement security in its broadest sense requires programs and policies that encourage and support flexible work that allow some choice and control over when, where, and how work gets done, and which work tasks are assumed by which employees or work teams, self-employment, and formal and informal volunteer work. This article has 3 purposes: (a) to summarize the current context of retirement, (b) to identify barriers to psychological security in later life, and (c) to suggest how psychologists can support the rewriting of the retirement chapter for future retirees. (PsycINFO Database Record
Research on scheduling of real-time messages over master-slave switched Ethernet

To make switched Ethernet meet the requirements of real-time communication,a novel link schedulability analysis method for both periodic and aperiodic real-time messages is proposed based on FTT-SE(Flexible Time Triggered Switched Ethernet)paradigm.In addition,it is proved that finding the optimal schedule for a given set of periodic messages on transmission links in order to minimize the maximum finishing time of reception links is NP-complete,and a heuristics algorithm named LSHA is proposed to solve this problem.Particularly,we design different EDF-based scheduling algorithms for periodic and aperiodic real-time messages respectively,which make it possible for the scheduler to take full advantage of multiple transmission paths,thus enhance the real-time communication over a COTS-based switched Ethernet.Simulation results show that the proposed Real-Time scheduling algorithm outperforms FTT-SE in terms of enhancing network bandwidth utilization and reducing average message delay.
Methods and the Margins: Realigning the Center, A Postscript

The idea for this book started as a conversation between friends in Barbara Dennis’ living room. The editors, together with Barbara Dennis, Adrea Lawrence, and Joshua Hunter, had come together to discuss our work and broadly some of the trends in educational research. It became an extended, if not unending, conversation. We were mindful of our elite position; in fact, one of the key points in our discussion was our relative security in the center. We were White, Western women and men who had not only the luxury of education, but the indulgence of time—time to think and explore new ideas and innovations. Yet, each of us shared stories of marginalization, because of our gender, our sexuality, our age, our reproductive decisions, our geography, and universally our intellectual work. In this latter category, all of our experiences seemed to mesh. It was the experience of marginalization that had led us to investigate certain topics in our research: birth education, educational experiences of marginalized groups in and outside of the United States, and the role of natural objects in educative experiences, to name a few.
Frontier Development as Job Creation — With Social Costs

Brazil, like every other land-based nation in the Western Hemisphere, has a frontier. It is not unreasonable to posit that the presence of a frontier has some effect on economic growth. Frontiers provide land, which is a form of capital. They provide mineral extractive sources that can be developed. They stimulate migration. This development is not cost free. The damage done by frontier openings to the environment and to indigenous populations is well known and of concern. However, the opening up of interior lands has some effect on economic growth, although the size of this effect has never been precisely estimated. If the effects of opening the frontier were small, it would make the ecological damage associated with this process indefensible. If the benefits of opening the frontier were substantial, this could pose significant moral and policy questions about the trade-offs between the elimination of poverty and the preservation of the environment.
Quality risk management for pharmaceutical manufacturing: The role of process modeling and simulations

This chapter discusses the use of process models to support quality risk management in pharmaceutical manufacturing. It starts with describing the elements of quality risk management, and then outlines how process models can aid the risk assessment process through sensitivity analysis and the evaluation of risk mitigation strategies through feasibility analysis. It then discusses different categories of process models based on their impact on product quality assurance, and the scientific considerations that may need to be taken into account to incorporate these process models into the quality risk management system. Finally, several case studies of continuous manufacturing are presented, illustrating the potential role of process models in the implementation of emerging manufacturing technologies.
Subclasses of (b, c)-inverses

For any semigroup S and any , the author [Linear Algebra Appl. 2012;436:1909–1923] introduced the idea of the (b, c)-inverse y of a, and then [Bicommuting properties of generalized inverses. Linear...
Abstract 20581: Population Based Characterization of the Definition, Prevalence and Associated Mortality of Pulmonary Hypertension in the Setting of Left Heart Disease

Purpose: Patients with left heart disease can develop pre-capillary pulmonary vascular remodeling, resulting in elevations of pulmonary vascular resistance (PVR). Pre-capillary pulmonary vascular disease has been variably defined by elevations in the transpulmonary or diastolic pulmonary pressure gradients (TPG or DPG) or PVR, but the optimal hemodynamic definition and predictor of mortality remains uncertain. Methods and Results: We retrospectively analyzed a large cohort of 10,023 subjects who had a right heart catheterization at our institution between 2005 and 2012, with linkage of catheterization data to electronic health records with natural language-based search and social security death index. Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) was defined as mPAP ≥25 mmHg, PCWP ≥15 mmHg and LVEF ≥ 45%, with variable TPG, PVR and DPG cut-off values to quantify severity of PH. Cox proportional hazard regression analysis was used. In cases of non-linear associations with mortality (PVR and DPG), hazard ratios were calculated based on spline models fit to a parameter. Of the 10,023 subjects, 21.4% have PH-HFpEF and 10.4%, 7.4% and 2.9% have PH-HFpEF with an elevated TPG (>12), PVR (≥3) and DPG (≥7), with 5-year survival rates of 50%, 46% and 45%, respectively (Figure 1). Predictive value was confirmed over a wide range of values by spline-modeled Cox analysis: TPG HR 1.02 (95%CI 1.01-1.02; P 1 (91% of observations); DPG HR 1.03 (95%CI 1.02-1.04; P Conclusions: PH-HFpEF is highly prevalent in patients referred for right heart catheterization. TPG, PVR and DPG are highly predictive of mortality by standard cut-offs and as continuous variables in a large PH-HFpEF cohort.
Sparse linear contextual bandits via relevance vector machines

This paper describes a linear multi-armed bandit algorithm that exploits sparsity in the underlying unknown weight vector controlling rewards. In linear multi-armed bandits, a user chooses a sequence of (slot machine) “arms” to pull, and each arm pull results in the user receiving a stochastic reward with mean equal to the inner product between a known feature vector associated with the arm and an unknown weight vector. While linear bandit algorithms have been widely considered in the literature, relatively little is known about how to exploit sparsity in the weight vector. This paper describes a novel approach that leverages ideas from linear Thompson sampling and relevance vector machines, resulting in a scalable approach that adapts to the unknown sparse support. Theoretical regret bounds highlight the proposed algorithm's performance as a function of the sparsity level, and simulations illustrate the advantages of the proposed method over several competing approaches.
A DSM-5-Based Online Mental Health Referral Inventory: A Large-Scale Validation Study

ABSTRACTIn 2007, a comprehensive mental health referral inventory based on the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) was posted online as an alternative to the informal tests the public now uses to self-diagnose mental health problems. A validation study was published in 2011 (Epstein & Muzzatti, 2011). In 2013, a revision of that inventory that was consistent with the DSM-5 was posted. The present study evaluates the new inventory with a diverse sample of 201,625 people from 184 countries (mainly the United States, Canada, and the United Kingdom). The 63-item inventory screens for 21 common problems and typically takes about 5 min to complete. Test scores proved to be good predictors of a variety of self-reported criterion measures, including happiness, personal and professional success, history of hospitalization, history of therapy, current participation in therapy, and employment. Females were found to have slightly more mental health problems than males, an...
Limb-Leaf designs for adaptive exploration of the dose-response curve.

Abstract We propose a two-stage strategy, called the Limb-Leaf method, to explore the dose-response curve using dose promotion and addition in the context of adaptive seamless Phase II/III trials. Strong control of the overall type 1 familywise error rate of the proposed method is enforced by the closed testing principle. The design constants are determined to minimize the risk-adjusted expected total sample size while maintaining a target power. In the case of a nonmonotonic dose response curve where more doses are required to adequately explore the curve, substantial savings in sample size are achieved compared with a traditional strategy which offers only selection and promotion from among initial first stage doses.
Brief Announcement: Applying Predicate Detection to the Stable Marriage Problem

We show that many techniques developed in the context of predicate detection are applicable to the stable marriage problem. The standard Gale-Shapley algorithm can be derived as a special case of detecting linear predicates. We also show that techniques in computation slicing can be used to represent the set of all constrained stable matchings.
SiC power MOSFET gate oxide breakdown reliability — Current status

SiC power MOSFET is poised to take off commercially. Gate oxide breakdown reliability is an important obstacle standing is the way. Early prediction of poor intrinsic reliability comparing to silicon MOSFET, while theoretically sound, has now proven way too pessimistic. Experimental data from good quality SiC MOSCAP turns out to have better breakdown lifetime than its silicon counterpart, based on data available in the literature. This surprising result is the consequence of improper extraction of intrinsic lifetime in the presence of extrinsic failures. Even though intrinsic lifetime is no longer an issue, SiC MOSFET gate oxide breakdown reliability is not out of the wood yet. This is because, for thick oxide, it is the extrinsic failure that determine lifetime, not intrinsic failure. Unfortunately, up to now there is no properly done study of SiC gate oxide extrinsic breakdown study reported in the literature.
Polyelectrolyte Complexes: Fluid or Solid?

Polyelectrolyte complexes that form between oppositely charged macromolecules could be solid or fluid, depending on water and salt content.
Getting Hit by Pitch in Professional Baseball: Analysis of Injury Patterns, Risk Factors, Concussions, and Days Missed for Batters:

Background:Although batters are frequently hit by pitch (HBP) in baseball, the effect of HBP injuries remains undefined in the literature.Purpose:To determine the effect of HBP injuries in terms of time out of play, injury patterns resulting in the greatest time out of play, and the value of protective gear such as helmets and elbow pads.Study Design:Descriptive laboratory study.Methods:Based on the Major League Baseball (MLB) Health and Injury Tracking System, all injuries to batters HBP during the 2011-2015 MLB and Minor League Baseball (MiLB) seasons were identified and analyzed. Video analysis was performed on all HBP events from the 2015 MLB season. Multivariate stepwise regression analysis was utilized to determine the predictive capacity of multiple variables (velocity, pitch type, location, etc) on injury status and severity.Results:A total of 2920 HBP injuries resulted in 24,624 days missed (DM) over the 5 seasons. MLB HBP injuries occurred at a rate of 1 per 2554 plate appearances (1 per 9780 pi...
Pore-scale statistics of flow and transport through porous media

Flow in porous media is known to be largely affected by pore morphology. In this work, we investigate the effects of pore geometry on the transport and spatial correlations of flow through porous media in two distinct pore structures arising from three-dimensional assemblies of overlapping and nonoverlapping spheres. Using high-resolution direct numerical simulations (DNS), we perform Eulerian and Lagrangian analysis of the flow and transport characteristics in porous media. We show that the Eulerian velocity distributions change from nearly exponential to Gaussian distributions as porosity increases. A stretched exponential distribution can be used to represent this behavior for a wide range of porosities. Evolution of Lagrangian velocities is studied for the uniform injection rule. Evaluation of tortuosity and trajectory length distributions of each porous medium shows that the model of overlapping spheres results in higher tortuosity and more skewed trajectory length distributions compared to the model of nonoverlapping spheres. Wider velocity distribution and higher tortuosity for overlapping spheres model give rise to non-Fickian transport while transport in nonoverlapping spheres model is found to be Fickian. Particularly, for overlapping spheres model our analysis of first-passage time distribution shows that the transport is very similar to those observed for sandstone. Finally, using three-dimensional (3D) velocity field obtained by DNS at the pore-scale, we quantitatively show that despite the randomness of pore-space, the spatially fluctuating velocity field and the 3D pore-space distribution are strongly correlated for a range of porous media from relatively homogeneous monodisperse sphere packs to Castlegate sandstone.
Squamous Intraepithelial Neoplasia

In our part of the world (the upper midwestern United States), squamous epithelial neoplasms of the esophagus have become rare, and the common esophageal carcinoma is the Barrett’s adenocarcinoma. As a result, we have had very little recent experience with squamous neoplasms. Therefore, the chapters devoted to these neoplasms may be less informative than comparable chapters written in places where they are still common, such as Japan.