cssi/SciSciGPT-SciSciNet huggingface dataset:
Supply chain process and agent design for e-commerce

Supply chain management represents a critical competency in today's fast-paced, global business environment, but neither EDI nor Web-based supply chain applications can enable both the process integration and flexibility demanded in the business environment of today. In contrast, intelligent agents offer potential and capability for buyer-seller integration and flexibility, and early applications show great promise for supply chain integration through agent technology. However, agent technology remains relatively immature, and we have yet to establish, test and verify good design principles and techniques like those now well established for other, more conventional software technologies. The research described in this paper builds upon recent work on agent-based supply chain integration to propose a set of techniques and tools to integrate process and agent design for the supply chain in an e-commerce context. Preliminary results from implementation include successful development of a supply chain agent federation and demonstration of its effective performance in a socially-conforming manner along the supply chain. Implications of this work with respect to the e-commerce context include the potential for rapid agent development by end users themselves.
On the Dynamics of Two Mutually-Coupled, Electromagnetically-Actuated Microbeam Oscillators

This work describes the modeling, analysis, predictive design, and control of self-excited oscillators, and associated arrays, founded upon electromagnetically-actuated microbeams. The study specifically focuses on the characterization of nonlinear behaviors arising in isolated oscillators and small arrays of nearly-identical, mutually-coupled oscillators. The work provides a framework for the exploration of larger oscillator arrays with different forms of coupling and feedback, which can be exploited in practical applications ranging from signal processing to micromechanical neurocomputing.© 2011 ASME
Chemical Safety in Animal Care, Use, and Research

Chemical safety is an essential element of an effective occupational health and safety program. Controlling exposures to chemical agents requires a careful process of hazard recognition, risk assessment, development of control measures, communication of the risks and control measures, and training to ensure that the indicated controls will be utilized. Managing chemical safety in animal care and use presents a unique challenge, in part because research is frequently conducted in two very different environments--the research laboratory and the animal care facility. The chemical agents specific to each of these environments are typically well understood by the employees working there; however, the extent of understanding may not be adequate when these individuals, or chemicals, cross over into the other environment. In addition, many chemicals utilized in animal research are not typically used in the research laboratory, and therefore the level of employee knowledge and proficiency may be less compared with more routinely used materials. Finally, the research protocol may involve the exposure of laboratory animals to either toxic chemicals or chemicals with unknown hazards. Such animal protocols require careful review to minimize the potential for unanticipated exposures of the research staff or animal care personnel. Numerous guidelines and regulations are cited, which define the standard of practice for the safe use of chemicals. Key chemical safety issues relevant to personnel involved in the care and use of research animals are discussed.
Rumford's Theory of Heat: A Reassessment

As a natural philosopher, Count Rumford is best known for his vehement advocacy of a motion or mechanical hypothesis of heat and for the dramatic experiments that he performed to support this hypothesis. Although a motion hypothesis which held that heat was merely the motion of the ultimate particles of a body had a distinguished history, with advocates that included Bacon, Boyle, Hooke, and Newton, most British natural philosophers by the beginning of the nineteenth century believed that the phenomena associated with heat were caused by an imponderable fluid. William Henry reflected contemporary opinion in 1803, when he wrote:The former of these opinions [i.e. the existence of caloric], though far from being universally admitted, is now generally received; and the peculiar body, to which the phenomena of heat are referred, has been denominated by M. Lavoisier [as] caloric.
Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer

The ubiquitin-proteasome system is essential for multiple physiological processes via selective degradation of target proteins and has been shown to plays a critical role in human cancer. Activation of oncogenic factors and inhibition of tumor suppressors have been shown to be essential for cancer development, and protein ubiquitination has been linked to the regulation of oncogenic factors and tumor suppressors. Three kinases, Akt, ERK, and IKK, we refer to as oncokinases, are activated in multiple human cancers. We and others have identified several key downstream targets that are commonly regulated by these oncokinases, some of which are regulated directly or indirectly via ubiquitin-mediated proteasome degradation, including FOXO3, β-catenin, Mcl-1, and Snail. In this review, we summarize these findings from our and other groups and discuss potential future studies and applications in the clinic.
Moral Repugnance, Moral Distress, and Organ Sales

Many still oppose legalizing markets in human organs on the grounds that they are morally repugnant. I will argue in this paper that the repugnance felt by some persons towards sales of human organs is insufficient to justify their prohibition. Yet this rejection of the view that markets in human organs should be prohibited because some persons find them to be morally repugnant does not imply that persons' feelings of distress at the possibility of organ sales are irrational. Eduardo Rivera-Lopez argues that such instinctive distress is an appropriate response to the (rationally defensible) perception that certain kinds of arguments that are offered in favor of legalizing organ sales are "in an important sense, illegitimate." Having argued that repugnance should not ground the prohibition of markets in human organs, I will also argue that the moral distress that some feel towards certain arguments that favor such markets is not rationally defensible, either.
Single-chip precision oscillators based on multi-frequency, high-Q aluminum nitride MEMS resonators

Aluminum nitride (AlN) contour mode resonators have been of interest because of their high quality factor, low impedance, large number of frequencies on a single chip and compatibility with CMOS processes [1–3]. While AlN low insertion loss filters [1–3] and oscillators [4–7] have been demonstrated, CMOS integration has yet to be accomplished. This work represents the first time fully-released contour mode AlN microresonators have been integrated with CMOS circuitry to obtain completely monolithic frequency references.
Fatigue cracking resistance of fiber-reinforced asphalt concrete

The influence of fibers on the fatigue cracking resistance of asphalt concrete is investigated using fracture energy. Nylon, a popular facing yarn of carpets, is used for the actual recycled carpet...
Salsa Dance and the Transformation of Style: An Ethnographic Study of Movement and Meaning in a Cross-Cultural Context

Over the last century perennial surges in the popularity of Latin American couple dance genres such as tango and rumba in the United States have served as lightning rods for debate on issues of morality, performance, and identity. These “crazes” have fueled the collective American imagination, reinforcing a type of Latin American exotica that prevailed throughout the twentieth century and into the next. Consequently, they have also fostered an entirely new style of performance as white Americans borrowed—or perhaps better stated, appropriated—these genres for their own. For instance, the two styles of tango performed by ballroom dancers today, some one hundred years after its introduction to American audiences in theaters and exhibition performances, is sufficiently distant from its Argentine roots to be considered an entirely different dance employing different movements, rhythms, and musical accompaniment. This article explores this particular brand of cross-cultural borrowing through an ethnographic accounting of a salsa dance formation team in central Illinois. Salsa is the latest of the Latin dance crazes, and since the earl. 1990. the genre has experienced increased attention from mainstream American audiences who have invested significant resources in order to learn to dance salsa. Formation teams are presentational performance ensembles, in this case combining salsa; ballroom; and staged, theatrical dance, and generally draw their enthusiasts from ballroom dance circles.
Evidence-Based Concept Mapping for the Athletic Training Student.

Context: A concept map is a graphical and cognitive tool that enables learners to link together interrelated concepts using propositions or statements that answer a posed problem. As an assessment ...
Orbital-scale glacio-eustasy in the Middle Devonian detected using oxygen isotopes of conodont apatite: Implications for long-term greenhouse–icehouse climatic transitions

Abstract Results from previous paleoclimate studies indicate Gondwanan glaciation, marking the onset of middle Paleozoic icehouse climate conditions, began by the Latest Devonian (Famennian). More recently, δ18O trends from conodont apatite suggest cooling Middle Devonian subtropical seasurface temperatures > 20 My prior to Famennian glaciation and high-latitude temperatures cool enough to permit the growth of continental glaciers which controlled longer term (My-scale) glacio-eustasy. This study evaluates the details and patterns of Middle Devonian high-frequency ( Thirteen complete Middle Devonian (Givetian) subtidal cycles (0.5–3 m thick) in the Little Cedar Formation of southeastern Iowa are characterized by oxygenated offshore facies (transgression), poorly oxygenated offshore facies (maximum flooding), a return to oxygenated facies, and are capped by bioturbated lower shoreface facies (regression/lowstand) which lack evidence of subaerial exposure. Across-shelf cyclostratigraphic facies relationships suggest relatively subdued water-depth changes were responsible for cycle development. Measured δ18O values from conodont apatite range from 15.9‰ to 18.4‰ and repeated, systematic intracycle trends are dominated by lower isotopic values in offshore facies and higher isotopic values in cycle-capping lower shoreface facies, which is consistent with glacio-eustasy driving the water-depth changes. The average ~ 0.6‰ magnitude of intracycle isotopic shift (0.2‰ to 1.0‰ = total range) suggests ~ 15–23 m glacio-eustatic oscillations were responsible for observed water-depth changes. The higher range of intracycle isotopic magnitudes may be the result of increased subtropical evaporation rates during glacial stages which locally enriched surface seawater δ18O values. Orbital-scale (
In Search of an Independent Judiciary: Alternatives to Judicial Elections in Mississippi

In Mississippi, state judges are judged by the electorate through a system of partisan elections. This article challenges whether popular election of judges is best suited to the goal of selecting the most qualified, independent, and responsible judiciary. Along the way, an overview of Mississippi's history with judicial selection will be offered, together with a critical analysis of its current system and a discussion of alternatives.
Abstract IA16: Acquired resistance to targeted therapeutics in hematologic malignancies

Targeted treatment approaches of hematologic malignancies provided many of the first inroads into the successful treatment of human malignancy with the emerging class of targeted therapeutics. Initial responsiveness to targeted therapy provides compelling evidence for the importance of specific targets for the maintenance of disease. Understanding mechanisms of acquired resistance further informs how malignant cells can circumvent target inhibition in patients, and in some instances, these insights have facilitated the successful development of next generation targeted therapeutics, best exemplified by BCR-ABL tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia (CML). As detailed genomic analyses are becoming more readily available, opportunities for developing and incorporating targeted therapeutics are expected to increase. It is becoming clear, however, that tumor heterogeneity in advanced hematologic malignancies can be substantial, and resistant subclones can compromise duration of response to targeted therapy. Several examples of acquired resistance to targeted therapeutics in human hematopoietic malignancies will be presented, as well as the implications of these molecular mechanisms toward future successful management of these diseases. Citation Format: Neil P. Shah. Acquired resistance to targeted therapeutics in hematologic malignancies. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr IA16.
Materials Development and Evaluation of Selective Laser Sintering Manufacturing Applications

This report summarizes the FY96 accomplishments for CRADA No. LA95C10254, "Materials Development and Evaluation of Laser Sintering Manufacturing Applications". To research the potential for processing additional materials using DTM Corporations Selective Laser Sintering rapid prototyping technology and evaluate the capability for rapid manufacturing applications, the following materials were processed experimentally using the Sinterstation 2000 platform; Linear Low Density Polyethylene thermoplastic; Polypropylene thermoplastic; Polysulfone thermoplastic; Polymethylpentene (TPX) thermoplastic; Carbon microsphere filled nylon 11; "APO-BMI" Apocure bismaleimide thermoset polyimide glass m.icrosphere filled and carbon microsphere filled formulations; and 900-24 physical properties mock for plastic bonded TATB high explosive These materials have been successfully processed to a "proof of concept" level or better (with the exception of No. 7). While none of these materials have been introduced as a standard product as of this date, the potential to do so is viable. Present status of materials processing efforts is presented in Section A 2.0. Some recent efforts in manufacturing applications is discussed in Section A 4.0.
HeRO graft versus lower extremity grafts in hemodialysis patients with long standing renal failure

BACKGROUND The role of the HeRO graft in central venous pathology has been defined in the literature and clinically. There have been two publications or abstracts that have compared the patency rates and outcomes of this graft to the lower extremity graft. AIM The outcomes of both publications leads to an algorithm suggested by the author in determining which procedure should be used for specific patients. METHODS Both papers trend to show that lower extremity grafts have improved patency rates when compared to the HeRO device in the upper extremity. DISCUSSION The author will use these data to demonstrate that in younger patients and in patients with low morbidity and mortality, salvaging the upper extremity area for access may show that the HeRO device provides benefit for these patients.
Adaptive OpenMP Task Scheduling Using Runtime APIs and Machine Learning

Task-based programming models adopt different scheduling strategies to exploit parallelism in irregular applications. These scheduling strategies differ in terms of exploiting data locality, maintaining load balance, and minimizing overhead. OpenMP tasks allow programmers to express unstructured parallelism at a high level of abstraction and make the runtime responsible about the burden of scheduling parallel execution. For irregular applications, the performance of task scheduling cannot often be predicted due to the nature of application, the used compiler, and the platform/architecture dependencies. In this work, we introduce an automatic, portable, and adaptive runtime feedback-driven framework (APARF) that combines standard low-level tasking runtime APIs, a developed profiling tool, and a hybrid machine learning model. We employ APARF to select the optimum task scheduling scheme of any given application using similarity analysis through the correlation between the captured runtime APIs with low profiling costs. Our hybrid model predicts the best scheduling strategy for a variety of unseen applications with an average accuracy of 93%, while maintaining a 100% training accuracy. An average performance enhancement of 25% was obtained compared with the default configuration, when APARF was applied on different unseen programs. APARF was examined against a real application (Molecular Dynamics), where we achieved up to 31% performance improvement. Compared to Intel, PGI and GNU compilers, our predicted scheme achieved better performance in most cases.
Contribution à la résolution collective de problème (Modèles d'auto-organisation par interactions directes et indirectes dans les SMA réactifs et robotiques)

This HDR habilitation (Habilitation a Diriger des Recherches) presents my researchs since 2002 as Associate Professor, first in Universite de Technologie de Belfort-Montbeliard, until 2006, and second, in Universite Henri Poincare (Nancy 1) in the Inria project-team Maia at LORIA Lab. This work concerns contributions to the field of collective problem solving when considering cooperative agents and/or robots. The presented models show how a set or a swarm of agents/robots can self-organize through direct or indirect interactions. The main applications concern mobile autonomous robots and autonomous vehicles.
Reference LD50 Values for Some Insecticides Against the Boll Weevil

The standard method (topical application) of determining resistance in Anthonomus grandis Boheman adopted by the Entomological Society of America was used to establish LD50 values for 6 experimental insecticides and 16 chemicals or chemical combinations. These values can serve as reference standards that may be used to detect changes in susceptibility. The average LD50’s ranged from 0.052 μg/weevil for methyl parathion to 39.490 for carbaryl. Also, the LD50’s obtained for toxaphene + DDT, methyl parathion, and carbaryl by the standard method were compared with the LC50’s obtained with an immersion method and a dry film method. The dry film method appeared more promising for a field test kit.
Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries

20-Hydroxyeicosatetraenoic acid (20-HETE), a potent vasoconstrictor and mediator of the myogenic response, is a major arachidonic acid metabolite in the microvasculature of the rat kidney formed pr...
The Effect of Watergate on Political Party Identification: Results from a 1970–1974 Panel Study

Abstract The large number of studies of the impact of Watergate have generally ignored its electoral repercussions. This paper helps to fill this void by reporting the results of a statewide panel study which investigated the effects of attitudes toward Watergate on shifts in political party identification between 1970 and 1974. We found a considerable amount of change in the partisan identifications of the panel members during the four years; however, while both parties suffered an overall loss of support to the “Independents,” the Republicans did lose considerably more support than did the Democrats. More importantly, the greater Republican losses were found to be significantly related to attitudes toward Watergate. It therefore appears that Watergate contributed to the shrinking proportion of Republicans within our panel. While the Republican losses were not of great magnitude, they appear sufficiently large to have had an effect on recent elections.
Factors Contributing to the Natural Control of Citrus Insects and Mites in Florida

Injurious insects and mites cause large annual losses of the citrus fruit crop in Florida. These losses, although expressed in reduction in yield, are a reflection of leaf, fruit, twig, and root injury by many minor and a few major injurious species. The losses would be even greater were it not for a relatively high degree of natural control which prevents many of the minor species from becoming of economic importance and to some extent limits injurious populations of the major species. At the present time biologic agents such as predators, insect parasites, and pathogenic agents appear to be the most important factors in the natural control of citrus insects and mites in Florida. This paper is concerned with a survey of these factors on the major injurious insects and mites and a preliminary evaluation of their importance to citrus production in the state.
House fly (Diptera: Muscidae) monitoring method comparisons and seasonal trends in environmentally controlled high-rise, caged-layer poultry houses.

Baited jug traps and 0.093-m2 counting stations were used to monitor adult Flies within the manure pits of five central Pennsylvania high-rise, caged-layer poultry houses. House flies, Musca domestica L., were the principal fly species at four of the houses and black garbage flies, Ophyra aenescens (Wiedemann), at the fifth house. Correlation analyses were used to compare counting-station (three positions: pit upper walls, lower walls, and posts) and baited jug trap house fly counts. Station-count positions were fairly well correlated with each other ( r2 = 0.20-0.84). Poor correlations between jug traps and most counting stations ( r2 = 0.07-0.57) suggest that 0.093-m2 counting stations were not reliable reflections of population density changes. Seasonal influences in the relationship between house fly activity indicated by counting stations, house fly abundance obtained by baited jug traps, and temperature were examined by linear regression. Temperature accounted for 19-26% of the variation at two of the houses but only 0-7% at the other two houses. The distribution of ventilation fans in the pit walls significantly affected baited jug trap counts.
Does the Summer Arctic Frontal Zone Influence Arctic Ocean Cyclone Activity

AbstractExtratropical cyclone activity over the central Arctic Ocean reaches its peak in summer. Previous research has argued for the existence of two external source regions for cyclones contributing to this summer maximum: the Eurasian continent interior and a narrow band of strong horizontal temperature gradients along the Arctic coastline known as the Arctic frontal zone (AFZ). This study incorporates data from an atmospheric reanalysis and an advanced cyclone detection and tracking algorithm to critically evaluate the relationship between the summer AFZ and cyclone activity in the central Arctic Ocean. Analysis of both individual cyclone tracks and seasonal fields of cyclone characteristics shows that the Arctic coast (and therefore the AFZ) is not a region of cyclogenesis. Rather, the AFZ acts as an intensification area for systems forming over Eurasia. As these systems migrate toward the Arctic Ocean, they experience greater deepening in situations when the AFZ is strong at midtropospheric levels. ...
Analysis and Protection of the Failure Mechanism of Long Cable for Motor Driver

The motor driving systems using long cable frequently appear cable insulation problems,whichseriously influence the reliable operation of the systems. Based on the analysis of the influences of frequency harmonicand voltage transient loss on the long cable insulation,the"converter-long cable-induction motor"simulation modelbased on PSCAD/EMTDC software was built,the over-voltage,over-current and the corresponding spectrum under thesituation of frequency harmonic and voltage transient loss were simulated and analyzed. The results show that theconverter output pulse produce nearly twice harmonic over- voltage in cable tapping through long cable,meawhileproduce a certain harmonic over-current,which results in the decrease of cable insulation;the induction motor delversits energy after happening voltage transient loss,which produce short-term high current that leads to the damage ofcable insulation. Based on the simulation results,a kind of second-order RLC low-pass filter was designed to suppressthe harm of frequency harmonic,and some protection was put forward to decrease the influence of voltage transientloss,which can effectively protect the cable insulation.
Epidemiological characteristics of human caliciviruses in infants and young children with acute diarrhea in Nanjing in 2009-2010

Objective To study molecular epidemiological characteristics of human caliciviruses among infants and young children aged 0-5 years old with acute diarrhea in Nanjing.Methods Stool specimens were collected from 300 infants and young children less than 5 years old admitted with acute gastroenteritis to Nanjing Children’s Hospital from July 2009 to June 2010.Human caliciviruses(including noroviruses and sapoviruses) were detected by RT-multiplex PCR.Results Human caliciviruses were identified in 71 cases from the 300 specimens and the detection rate was 23.67%.Out of these 71 positive samples,67 cases were Norovirus including 58 of GII/4(2006b strain),8 of GII/3 and 1 of GII/12;4 cases were Sapovirus including 2 of GI/1,1 of GI/2 and 1 of GII/1,respectively.Conclusions Human calicivirus is one of the main pathogens of diarrhea in infants and young children in Nanjing.Norovirus GII/4 genotype(2006b strain) was the most predominant strain.
THE FEATURES OF THE NETWORK POETRY LYRIC LANGUAGE

There are same lyric features and speech ways between network poetry and traditional poetry.But network poetry has unique features which are personal lyric,extra text lyric,oral lyric and narrative lyric.
Management strategies in respiratory failure.

Putting a critically ill patient back on the road to recovery is as much a matter of rehabilitative as of acute care. A metaphor that works effectively for this purpose is the patient as athlete preparing for a major competition. A five-point training protocol is discussed in the context of total management of respiratory dysfunction in an intensive care setting.
Different Ways of Measuring Emotions Cross-Culturally

Abstract There is no doubt that our emotions reflect our evolutionary heritage. Most humans around the world experience and express broadly similar emotional responses to significant events, such as bonding with others, prevailing over challenges, losing something or someone, or coping with threats to self or others. A rapidly expanding body of work illustrates that our emotions also reflect our cultural contexts. For example, a minor insult is more likely to trigger physiological and behavioral signs of rage among people from cultural contexts that emphasize honor concerns (eg, American South). Much of what we currently knowabout emotions is based on emotions of college students in North America and Western Europe, two sets of cultural contexts that are not representative of the world’s diversity. Recently, researchers have been extending the study of emotions to people in cultural contexts with different models of emotions that are important, appropriate, desirable, and functional. There is much to gain from pursuing this work. In doing so, we may learn more about emotions, about culture, and about the interactions between the two, as well as examine practical questions that involve both constructs (eg, comparing people’s responses to a political campaign). This chapter will review extant work in the field, with special attention given to methodological challenges posed by assessing emotions across cultural contexts and best practices for doing so.
Regulation of Muscarinic Receptor Binding

The specific binding of [3H] antagonists to muscarinic receptors from neuronal tissue has been demonstrated by several investigators (6,19,24,28,32,37). In each case, the binding of [3H] antagonists is consistent with the law of mass action for a single class of independent receptors. Similarly, the results of antagonist/ [3H] antagonist competition experiments are also consistent with the law of mass action (23). Perhaps the most convincing evidence demonstrating that the binding of [3H] antagonists represents a specific interaction with the muscarinic receptor is the excellent quantitative agreement between the values of dissociation constants determined by binding experiments and by antagonism of agonist induced contractions of the guinea pig ileum (8,10).
The development of sweet taste: From biology to hedonics.

From the age of 2 years, an American child is more likely to consume a sugar-sweetened product than a fruit or vegetable on any given day—a troubling statistic, given that food preferences are established early in childhood, as well as the strong association between this dietary pattern and increased risk of developing a number of chronic diseases. Here, we review the ontogeny and biopsychology of sweet taste, highlighting how a biological drive to prefer sweetness at high concentrations during childhood, which would have conferred an advantage in environments of scarcity, now predisposes children to overconsume all that is sweet in a modern food system replete with added sugars. We review the power of sweet taste to blunt expressions of pain and mask bad tastes in foods as well as factors that predispose some to consume high-sugar diets, including experiential learning and taste preferences driven in part by genetics. Understanding children’s unique vulnerability to our current food environment, rich in both nutritive and nonnutritive sweeteners, is highlighted as a priority for future research to develop evidence-based strategies to help establish healthy dietary behaviors early in life.
SP0191 Measuring Quality of Life in Young Adults with Jia in Clinical Practice

Background Children and adolescents with Juvenile Idiopathic Arthritis (JIA) are at risk for the development of psychosocial problems and a lowered Health Related Quality of Life (HRQOL). These problems are not always identified during consultations with a rheumatologist. Therefore, adequate screening, monitoring and providing tailored interventions is necessary. The goal of the KLIK program is therefore to monitor the HRQOL and psychosocial functioning of children and young adults with chronic illnesses over extended periods of time and to facilitate communication between patient and practitioner. Children (0-18 years) or their parents complete questionnaires on www.hetklikt.nu before a consultation. The basis of KLIK is a generic HRQOL questionnaire. The decision of disease-specific HRQOL and psychosocial questionnaires is based on focus groups with practitioners. The answers on the questionnaires (Patient Reported Outcomes) are converted into a KLIK ePROfile. The KLIK ePROfile consists of a literal representation of the answers and a graphic presentation. The KLIK ePROfiles are available prior to a consultation. The practitioner retrieves the ePROfile from the website and discusses this with the patient and parents. The KLIK program is effective in increasing discussion about emotional and psychosocial functioning in pediatric care. However, young adults can also benefit from the use of KLIK in adult care. The aim of this project is to adapt the KLIK program for young adults and facilitate transition. Methods To adapt the website for young adults (16-30 years) we will conduct focus groups in order to select the most important themes. To know where their major problems in psychosocial functioning and HRQOL are and to select the most suitable questionnaires for feedback in the KLIK program, we will conduct a cross-sectional study. After this we will change the lay-out of the website to make it more usable for young adults. Results Since implementation began in pediatric care in 2011, 31 patient groups, (including children with JIA) over 300 professionals in 8 different hospitals and around 3000 pediatric patients have started using KLIK in the Netherlands. The first steps in adapting KLIK for young adults are taken by conducting the first focus groups and by adding transition-specific questionnaires to the KLIK website. Conclusions The implementation of KLIK appears to be feasible and workable in pediatric care, and with information from focus groups, cross-sectional research and adaption of the website for young adults we will explore if the program is also feasible in adult care. Disclosure of Interest None declared
A Bicistronic Therapeutic Retroviral Vector Enables Sorting of Transduced CD34+ Cells and Corrects the Enzyme Deficiency in Cells From Gaucher Patients

Corrective gene transfer for therapeutic intervention in metabolic and hematopoietic disorders has been hampered by the relatively inefficient transduction of human hematopoietic stem cells. To overcome this, a bicistronic recombinant retrovirus has been generated that delivers both a therapeutic glucocerebrosidase (GC) cDNA for the treatment of Gaucher disease, and a small murine cell surface antigen (heat-stable antigen [HSA]) as a selectable marker. An amphotropic retroviral-producing cell clone was created, and filtered supernatant was used to transduce NIH 3T3 cells. Sorting of transduced cells by flow cytometry enabled separation into populations based on cell surface fluorescence intensity derived from the expressed HSA. Significant increases in GC enzyme activity were seen for the transduced and especially the transduced and sorted cells. Similarly, increases in GC specific activity were seen in transduced and sorted skin fibroblasts from a patient with Gaucher disease. To streamline future transfer and sorting protocols for hematopoietic cells, transformed B-cell lines from Gaucher patients were created. Type I B cells were transduced and sorted, and large increases in GC specific activity occurred with concomitant increases in integrated retroviral copy numbers. In addition, toward the goal of using this selectable approach for corrective gene transfer to bone marrow stem cells, CD34+ cells were isolated from normal BM donors, transduced, and sorted based on cell surface expression of HSA. Proviral DNA was detected in approximately 40% of clonogenic progenitor colonies derived from unsorted, transduced CD34+ cells, demonstrating the high titer of the vector. However, after sorting, 100% of the colonies had the corrective GC cDNA, demonstrating the efficiency of this selective system for human hematopoietic progenitors. It is expected that strategies based on this approach will allow sorting of transduced cells of many types before implantation of transduced cells to animals or patients. This vector system may also be used to simplify manipulations and studies on retroviral-mediated gene delivery in vitro and for in vivo models.
Increasing the usability of drought information for risk management in the Arbuckle Simpson Aquifer, Oklahoma

Abstract Tools are needed that can add value to existing drought information and customize it for specific drought management contexts. This study develops a generalized framework that can be used to link local impacts with readily available drought information, thus increasing the usability of existing drought products in decision making. We offer a three-step risk-based framework that can be applied to specific decision-making contexts: (i) identify hydrologic impact thresholds, (ii) develop threshold exceedance model, and (iii) evaluate exceedance likelihood. The framework is demonstrated using a study site in south-central Oklahoma, which is highly susceptible to drought and faces management challenges. Stakeholder input from interviews are used to identify “moderate” and “extreme” thresholds below which water needs are not met for important uses. A logistic regression model translates existing drought information to the likelihood of exceeding the identified thresholds. The logistic model offers an improvement over climatology, and the 12-month Standardized Precipitation Index is shown to be the best drought index predictor. The logistic model is used in conjunction with historical drought information to give a retrospective look at the risk of drought impacts from the beginning of the century. Results show the 1980s to early 2000s to be an anomalously wet period, and that recent drying trends and impacts do not appear to be unusual for the 20th century. This drought risk analysis can be used as a baseline by local managers to guide future decision making under climate uncertainty.
Lagrangians and Integrals of Motion for Multi-Degree-of-Freedom Linear Systems with Gyroscopic and Circulatory Forces

This paper deals with multi-degree-of-freedom linear dynamic systems that may be subjected to damping, gyroscopic, and circulatory forces. Under suitable conditions, Lagrangians are obtained for su...
Identification of flight maneuvers and aircraft types utilizing unsupervised learning with big data

Security professionals are interested in knowing with a high level of confidence the details of each flight beyond what the self-broadcasted data provides. A program run by the Air Force is attempting to better characterize flights. From various data sources, this program attempts to determine aircraft identities. The purpose of this study is to test unsupervised machine learning methods to improve the Air Force's aircraft identification process. These alternative methods cluster unlabeled aircraft flight data from which we identify different aircraft types and maneuvers. The alternate methods include k-means and k-medoids. To improve the clustering, we first perform feature engineering. Some of the features built include acceleration rates, G forces, specific excess power, flight path angle, flight efficiency, and winding number. We then cluster the data using the above features and determine the ideal number of clusters via the average silhouette width. The initial clusters identify discrete flight maneuvers, such as takeoff and landing, and from these initial clusters we utilize sub-clustering to identify aircraft. To validate our aircraft identification process, we implement web scraping to develop a labeled dataset to compare the distribution of aircraft within the sub-cluster versus the initial cluster. The final model uses k-means, and 12 of the 14 sub-clusters generated by it have statistically different distributions of aircraft at α = 0.01 from the initial clusters. This indicates that we can better identify aircraft type given in which sub-cluster a data point resides. With some modifications, the method could be used by the Air Force to augment the current identification process.
Using 3-D Similarity Searching to Develop Synthetic Targets

One of the key challenges facing the medicinal chemist is converting data obtained from X-ray crystallography, biological screening, and mechanism studies into ideas for new synthetic targets. To develop these new targets, two problems must be solved. First, a pharmacophore model representing the 3-D arrangement of the functional groups required for biological activity must be developed. Then, a molecular framework must be found which can position these functional groups in the proper 3-D orientation. This paper reviews our approaches to developing pharmacophore models and how these models can be used as input for searching 3-D databases to find desirable molecular ‘frameworks’. Our 3-D searching is done using the GEOSTAT software from the Cambridge Crystallographic Data Centre and Molecular Design Limited’s MACCS-3D software. Results for several pharmacophores will be used to illustrate how the technique can be used to develop novel synthetic targets.
Undergraduate Research and Training in Ion-Beam Analysis of Environmental Materials ☆

Abstract We have an active undergraduate research program at the Union College Ion-Beam Analysis Laboratory (UCIBAL) focused on the study of environmental materials. Accelerator-based ion-beam analysis (IBA) is a powerful tool for the study of environmental pollution because it can provide information on a broad range of elements with high sensitivity and low detection limits, is non-destructive, and requires little or no sample preparation. It also provides excellent training for the next generation of environmental scientists. Beams of protons and alpha particles with energies of a few MeV from the 1.1-MV tandem Pelletron accelerator (NEC Model 3SDH) in the UCIBAL are used to characterize environmental samples using IBA techniques such as proton-induced X-ray emission, Rutherford back-scattering, and proton-induced gamma-ray emission. Recent projects include the characterization of atmospheric aerosols in the Adirondack Mountains of upstate New York, the study of heavy metal pollutants in river sediment, measurements of Pb diffusion in sulfide minerals to help constrain the determination of the age of iron meteorites, and the search for heavy metals and toxins in artificial turf.
Review of The Black Urban Atlantic in the Age of the Slave Trade, by Jorge Cañizares-Esguerra et al., & The Brink of Freedom; Improvising life in the Nineteenth-Century Atlantic World, by David Kazanjian

The Black Urban Atlantic in the Age of the Slave Trade, by Jorge Canizares-Esguerra et al. University of Pennsylvania Press, 2016 The Brink of Freedom; Improvising life in the Nineteenth-Century Atlantic World , by David Kazanjian. Duke University Press, 2016
A dividerless reference-sampling RF PLL with −253.5dB jitter FOM and <-67dBc Reference Spurs

In the recent past, there have been exciting advances in dividerless PLLs, such as sub-sampling PLLs (SSPLLs) [1,2] and injection-locked clock multipliers (ILCMs) [3] that substantially reduce loop noise to cross the −250dB jitter-power figure-of-merit (FOM,) barrier. However, there exists a fundamental trade-off between FOM, and reference spurs in PLLs, although the mechanisms vary across architectures. Narrow PLL bandwidths are necessary for reducing spurs through filtering, but this can conflict with the optimal bandwidth for jitter. In SSPLLs, buffers, isolating the VCO from the sub-sampled phase detector (SSPD) (Fig. 15.7.1), reduce spurs at the expense of noise and power consumption. Smaller sample capacitances in the SSPD reduce spurs generated by mismatch-induced charge sharing, charge injection, and tank frequency modulation at the expense of increased kT/C noise. Consequently, the SSPLL of [2] achieves spur <-80dBc by using isolation buffers, a small sample capacitance (and another DLL-based technique) but exhibits an FOM, of −244.6dB. In the SSPLL of [1], the elimination of this isolation buffer and the use of a larger capacitance results in a better FOM, of −252dB but a spur of −56dBc. The ILCM in [3] operates with large injection to enable locking to a high multiple of the reference, but this degrades spurs. The absence of noisy loop components yields a very low, but large injection leads to a spur of −43dBc. Also, ILCMs do not feature explicit phase detectors, limiting the optimization of loop dynamics.
Surface analysis: From single crystals to biomaterials

Surfaces and interfaces play a critical role in material performance in many applications including catalysis, biomaterials, microelectronics, tribology and adhesion. Characterizing the important surfaces and interfaces involved in each application may present different challenges, but the approach to investigating them often is rather similar. Specialized instrumentation is typically used to probe the surface region of a material and often times it is required to develop new instrumentation and data analysis methods to obtain the desired information. It usually best to use multiple experimental techniques, often coupled with theoretical calculations and simulations, to gain a more complete understanding of the surface and interface regions. Careful handling and preparation of the samples is required so the surface is not altered during these processes as well as during analysis. Using model samples with well-defined surface structures and compositions can provide information about fundamental processes as well as help develop the analytical tools and methodology needed to characterize complex surfaces and interfaces. Thus, the expertise and experience a surface analyst acquires in one field can be readily applied to other fields, even when those fields are significantly differently (e.g., biomaterials and microelectronics). This has resulted in surface analysts moving rather easily between different research and application areas. As one example my career path of small molecule chemisorption and reactivity on single crystals to industrial catalysis to biomedical surface science is presented in this manuscript.
Diamond: Potential and Status

Consider virtually any material property; the value of that property in diamond is virtually certain to represent an extremest value. Although the superlative properties of diamond were known for centuries, knowledge of its wholly carbon constitution came much later. It was the French chemist Antoine L. Lavoisier who found in 1772 that the products of combustion of diamond were singular: CO2. This knowledge of the carbon constituency did not, however, precipitate a rush toward artifact diamond. The first written claim to artifact diamond was made sixty years later by C. Cagniard de la Tour, but the products of his endeavors are no longer to be found. In 1880, J. B. Hanney allegedly synthesized diamond from lithium, bone meal, and mineral oil heated together in a wrought iron tube. His products are on display in the British Museum. Thirteen years after that Henry Moisson developed a procedure that heated sugar charcoal and iron to a molten mixture in an electric furnace and followed by a water quench. The Nobel award winning high pressure work of Percy Bridgman of Harvard University in the 1940s pointed the way toward combining the electric furnace with high pressure to create quality artifact diamond. This approach first became publicly known in the 1950s by a team at General Electric but similar documented but unreported work may have occurred earlier in Sweden. From this time forward the wonder material improved in quality and size until today it is possible to produce artifact diamond films and to coat various materials with polycrystalline diamond.