cssi/SciSciGPT-SciSciNet huggingface dataset:
Psychological interventions helping pediatric oncology patients cope with medical procedures: a nurse-centered approach.

Abstract Purpose of the research This study explored whether psychological interventions are currently used by pediatric oncology nurses to help children cope with their treatment and, if so, which interventions were considered by oncology nurses to be the most effective. Methods and sample A web-based survey was developed to assess pediatric oncology nurses' impressions of psychological care for pediatric patients during their medical treatment. A sample of 88 pediatric oncologic nurses from twelve leading pediatric oncology departments in the US participated in the survey. The closed questions were analyzed through quantitative methods with statistics. The open questions were examined through qualitative methods with report narratives and discourse analysis. Key results Pediatric oncology nurses identified three psychological interventions to reduce suffering: educating children by explaining the procedure; providing emotional support to children by listening, answering children's worries, or holding their hands; and distracting children through passive and active forms. The survey further showed that nurses spent on average 3 h per day providing emotional support, would be willing to be trained in additional interventions (93%), and could devote at least 10 min per treatment to provide support (77%). Conclusions This work demonstrates the central role nurses play as emotional support caregivers. Since nurses would be willing to provide emotional support during treatments, training may be an approach to incorporate the use of psychological interventions.
Parsing speech into articulatory events

In this paper, the states in the speech production process are defined by a number of categorical articulatory features. We describe a detector that outputs a stream (sequence of classes) for each articulatory feature given the Mel frequency cepstral coefficient (MFCC) representation of the input speech. The detector consists of a bank of recurrent neural network (RNN) classifiers, a variable depth lattice generator and Viterbi decoder. A bank of classifiers has been previously used for articulatory feature detection by many researchers. We extend their work first by creating variable depth lattices for each feature and then by combining them into product lattices for rescoring using the Viterbi algorithm. During the rescoring we incorporate language and duration constraints along with the posterior probabilities of classes provided by the RNN classifiers. We present our results for the place and manner features using TIMIT data, and compare the results to a baseline system. We report performance improvements both at the frame and segment levels.
Training At-Risk Youth to Become Diabetes Self-management Coaches for Family Members Partnering Family Medicine Residents With Underserved Schools

PurposeThe purpose of this study is to evaluate the impact of a school-based health program in which family medicine residents trained healthy at-risk adolescents to become diabetes self-management coaches for family members with diabetes.MethodsA mixed methods study included 97 adolescents from 3 San Francisco Bay Area high schools serving primarily ethnic minority youth of low socioeconomic status. Physicians came to schools once a week for 8 weeks and trained 49 adolescents to become coaches. Student coaches and 48 nonparticipant students completed pre- and posttest intervention questionnaires, and 15 student coaches and 9 family members with diabetes gave in-depth interviews after participation. Linear regression was used to determine differences in knowledge and psychosocial assets on pre- and posttests between student coaches and nonparticipant students, and NVIVO was used to analyze interview transcripts.ResultsAfter controlling for initial score, sex, grade, and ethnicity, student coaches improved...
Clustering for opportunistic communication

We describe ongoing work on I2I, a system aimed at fostering opportunistic communication among users viewing or manipulating content on the Web and in productivity applications. Unlike previous work in which the URLs of Web resources are used to group users visiting the same resource, we present a more general framework for clustering work contexts to group users together that accounts for dynamic content and distributional properties of Web accesses which can limit the utility URL based systems. In addition, we describe a method for scaffolding asynchronous communication in the context of an ongoing task that takes into account the ephemeral nature of the location of content on the Web. The techniques we describe also nicely cover local files in progress, in addition to publicly available Web content. We present the results of several evaluations that indicate systems that use the techniques we employ may be more useful than systems that are strictly URL based.
Robust distributed network localization with noisy range measurements

This paper describes a distributed, linear-time algorithm for localizing sensor network nodes in the presence of range measurement noise and demonstrates the algorithm on a physical network. We introduce the probabilistic notion of robust quadrilaterals as a way to avoid flip ambiguities that otherwise corrupt localization computations. We formulate the localization problem as a two-dimensional graph realization problem: given a planar graph with approximately known edge lengths, recover the Euclidean position of each vertex up to a global rotation and translation. This formulation is applicable to the localization of sensor networks in which each node can estimate the distance to each of its neighbors, but no absolute position reference such as GPS or fixed anchor nodes is available.We implemented the algorithm on a physical sensor network and empirically assessed its accuracy and performance. Also, in simulation, we demonstrate that the algorithm scales to large networks and handles real-world deployment geometries. Finally, we show how the algorithm supports localization of mobile nodes.
Observations on the Securitization of Non-Performing Loans in Russia

Asset securitization is a burgeoning trend in Russia as companies burdened by poor credit ratings seek access to capital at lower costs than they would be allowed in traditional equity or debt markets. In other countries, non-performing loan portfolios are assets that are frequently securitized. But securitization of these bad loans has not occurred in Russia at the levels one might expect. This has been due to both a relatively small amount of loans that under-perform as well as legal and regulatory impediments that have discouraged investors and lenders alike. However, expansion of consumer credit in Russia and the circumstances under which it is occurring indicate that the level of non-performing loans is due to rapidly increase and as the rationale for maintaining the impediments that stand in the way of securitizing these loans is being re-examined, those impediments are being scaled back to make way for market participants to engage in such securitizations. Thus, this article anticipates a significant rise in the level of non-performing loans, which will be logically paired with an increased interest of Russian lenders in securitizing these assets.
Performance assessment of cascade control loops

The minimum variance control law for a cascade control system is derived for two cases: the primary process has stable and unstable inverses. The expression for the primary output variable under the minimum variance cascade control is shown to be feedback-invariant. An estimate of the minimum achievable variance in a cascade control loop can be obtained via multivariate time-series modeling of the primary and secondary measurements collected under normal operation. The utility of the proposed performance assessment method is demonstrated using simulated and industrial data.
Impulsive choice and anxiety-like behavior in adult rats exposed to chronic intermittent ethanol during adolescence and adulthood.

Abstract Binge drinking during adolescence and adulthood may have differential long-term effects on the brain. We investigated the long-term effects of chronic intermittent ethanol (CIE) exposure during adolescence and adulthood on impulsivity and anxiety-like behavior. Adolescent (adolescent-exposed) and adult (adult-exposed) rats were exposed to CIE/water on postnatal days (PND) 28–53 and PND146–171, respectively, and a 4-day ethanol/water binge on PND181–184 and PND271–274, respectively. During withdrawal from CIE and 4-day binge exposures, anxiety-like behavior and arousal were measured in the light-potentiated startle (LPS) and acoustic startle (ASR) procedures, respectively. Impulsive choice was evaluated in the delay discounting task (DDT) at baseline and after ethanol challenges. Independent of age, ASR and LPS were decreased during withdrawal from CIE exposure. In contrast, LPS was increased in adult-exposed, but not adolescent-exposed, rats during withdrawal from the 4-day ethanol binge. CIE exposure had no effect on preference for the large delayed reward at baseline, independent of age. During DDT acquisition, CIE-exposed, compared with water-exposed rats, omitted more responses, independent of age, suggesting the CIE-induced disruption of cognitive processes. Ethanol challenges decreased preference for the large reward in younger adolescent-exposed rats but had no effect in older adult-exposed rats, independent of previous CIE/water exposure. Taken together, the present studies demonstrate that CIE withdrawal-induced decreases in anxiety and arousal were not age-specific. CIE exposure had no long-term effects on baseline impulsive choice. Subsequent ethanol exposure produced age-dependent effects on impulsivity (increased impulsivity in younger adolescent-exposed rats) and anxiety-like behavior (increased anxiety-like behavior in older adult-exposed rats).
Modeling dense nonaqueous phase liquid mass removal in nonuniform formations: Linking source-zone architecture and system response

Dense nonaqueous phase liquid (DNAPL) source zones comprise persistent sources of groundwater contamination that are recalcitrant to complete remediation using conventional (e.g., pump and treat) or emerging (e.g., surfactant flushing) technologies. Increased attention to the assessment of the benefits of partial mass removal from such contaminant source zones has intensified efforts to model multiphase flow and transport behavior. This paper describes the simulated recovery of a tetrachloroethene (PCE) spill in a statistically homogeneous but nonuniform aquifer, incorporating nonuniformity in both nonaqueous phase liquid saturation and pore velocities. We developed a ganglia-to-pool metric to quantify DNAPL source-zone architecture, and explored the correlation of this metric with dissolved mass flux behavior in response to partial DNAPL mass removal. Dissolution of 20%‐70% of PCE mass from models exhibiting low ganglia-to-pool ratios resulted in a larger predicted reduction of dissolved contaminant mass flux than models with high ganglia-to-pool ratios. Results of this study suggest that DNAPL source-zone characterization at field sites with homogeneous, nonuniform aquifers would benefit from inclusion of an estimate of the overall ganglia-to-pool ratio. Simulations demonstrate that flux reduction behavior depends on the source-zone architecture, which is not readily predictable using a priori assumptions about the spatial correlation of physical aquifer parameters. Model results further suggest that stochastic investigations of DNAPL source remediation at field sites should avoid reliance upon Leverett scaling of capillary entry pressures to permeability fields, which can artificially narrow the range of simulated behaviors.
Magnitude of Missed Esophageal Adenocarcinoma after Barrett's Esophagus Diagnosis: A Systematic Review and Meta-analysis

Background & Aims A proportion of patients with Barrett's esophagus (BE) are diagnosed with esophageal adenocarcinoma (EAC) within 1 year of an endoscopic examination that produced negative findings. These cases of missed cancers have not been well studied, despite current surveillance strategies for BE. We performed a systematic review and meta-analysis to determine the magnitude of missed EAC in cohorts of patients with BE. Methods We searched MEDLINE, EMBASE, and Web of Science from their inception to May 31, 2015 to identify cohort studies of adults with BE (baseline nondysplastic BE ± BE with low-grade dysplasia) and at least a 3-year follow-up period, providing data on missed and incident EACs (diagnosed within 1 year and diagnosed more than 1 year after the initial endoscopy in which BE was diagnosed, respectively). The main outcome measure was pooled proportion of missed and incident EACs (of all EACs detected after initial endoscopy) among BE cohorts, using a random effects model. Results In a meta-analysis of 24 studies reporting on 820 missed and incident EACs, 25.3% were classified as missed (95% confidence interval: 16.4%–36.8%) and 74.7% as incident EACs (95% CI: 63.2%–83.6%), although there was substantial heterogeneity among studies (I 2 = 74%). When the analysis was restricted to nondysplastic BE cohorts (15 studies), 23.9% of EACs were classified as missed (95% confidence interval: 15.3%–35.4%; I 2 = 0%). In a meta-analysis of 10 studies with follow-up periods of ≥5 years (a total of 239 EACs), 22.0% were classified as missed (95% confidence interval: 8.7%–45.5%), with substantial heterogeneity (I 2 = 68%). Conclusions Among adults with nondysplastic BE (or BE with low-grade dysplasia) at their index endoscopy and at least a 3-year follow-up period, 25% of EACs are diagnosed within 1 year after the index endoscopy. Additional resources should be allocated to detect missed EAC.
Scalable network analysis

Unstructured data is being generated at a tremendous rate in modern applications as diverse as social networks, recommender systems, genomics, health care and energy management. Networks are an important example of unstructured data and may arise explicitly, as in social networks, or implicitly, as in recommender systems. These networks are challenging to handle; not only are they large-scale but they are constantly evolving, and many applications require difficult prediction tasks to be solved, such as link or ratings prediction. In this talk, I will discuss scalable solutions for a class of prediction tasks on large-scale networks, that involve algorithmic innovation in response to the demands of modern computer systems.
A cyber-physical system for senior collapse detection

Senior Collapse Detection (SCD) is a system that uses cyber-physical techniques to create a "smart home" system to predict and detect the falling of senior/geriatric participants in home environments. This software application addresses the needs of millions of senior citizens who live at home by themselves and can find themselves in situations where they have fallen and need assistance. We discuss how SCD uses imagery, depth and audio to fuse and interact in a system that does not require the senior to wear any devices allowing them to be more autonomous. The Microsoft Kinect Sensor is used to collect imagery, depth and audio. We will begin by discussing the physical attributes of the "collapse detection problem". Next, we will discuss the task of feature extraction resulting in skeleton and joint tracking. Improvements in error detection of joint tracking will be highlighted. Next, we discuss the main module of "fall detection" using our mid-level skeleton features. Attributes including acceleration, position and room environment factor into the SCD fall detection decision. Finally, how a detected fall and the resultant emergency response are handled will be presented. RESULTS in a home environment will be given.
Prognostic significance of WT-1 levels in patients with myelodysplastic syndrome and leukemia after reduced-intensity allogeneic transplantation

6524 Background: Expression of WT-1, a zinc-finger transcription factor, is elevated at diagnosis in many kinds of leukemia. The prognostic significance of the WT-1 transcript level before and after stem cell transplant is controversial. We performed real-time quantitative PCR (RQ-PCR) on samples from pts with leukemia and MDS undergoing allo stem-cell transplant (SCT) to determine if WT-1 expression correlates with survival (OS) and/or disease-free survival (DFS). Methods: Pts were conditioned with fludarabine, melphalan and alemtuzumab. cDNA was synthesized for RQ-PCR, which was performed on bone marrow (BM) and peripheral blood (PB) samples drawn prior to transplant admission and at day 28 (D28) post transplantation. All samples were analyzed using LightCycler technology and reported as a normalized ratio of WT-1 copy number to ABL copy number. Results: Data on 48 patients who underwent allo SCT are reported here. During a median follow up of 17 months, 24 patients died and the OS rate at one year was ...
Choosing an appropriate alliance governance mode: The role of institutional, cultural and geographical distance in international research & development (R&D) collaborations

We identify a variety of R&D alliance modes in a knowledge-intensive industry (e.g., Pharmaceuticals), and classify them into four ordered categories which go beyond the traditional binary equity vs non-equity alliance classification. This enriches our understanding of alliance governance structures and broadens the application of alliance modes in what is today a more complicated international R&D collaboration setting. We then explore national, industry and firm factors that determine the selection of an appropriate R&D alliance governance mode, using a sample of 237 international alliance deals. The likelihood of using a more-integrated alliance governance mode decreases as the difference or “distance” between nations of the partner firms increases in terms of human capital and cultural distance. On the other hand, a greater geographic and institutional difference is positively associated with the selection of more integrated alliance governance modes. Furthermore, firms in the research stage are more likely to use a more-integrated governance mode, as opposed to firms in the development stage. These findings advance research on alliance governance structure. They reveal the factors affecting the R&D alliance governance mode choice.
P-006 Safety and Efficacy of Endovascular Treatment of Paraophthalmic Internal Carotid Artery Aneurysms

Introduction/Purpose Within the literature, controversy exists regarding the optimal treatment of ophthalmic segment internal carotid artery aneurysms. The close proximity of the ophthalmic artery and optic nerve increase the complexity of the disease, and the adjacent clinoid process impedes surgical exposure. This study investigates the safety and efficacy of coil embolisation for the treatment of paraophthalmic internal carotid artery aneurysms. Method A retrospective chart review identified 79 consecutive aneurysms who presented for elective treatment of an ophthalmic artery aneurysm. Patient demographics, details of treatments, effects of treatments, results of follow up procedures, and complications were recorded. Odds ratios were used to measure the effect size. The McNemar Test for systematic discordance was used to test the likelihood of visual improvement or degradation. Results Primary occlusion rate was 44%. The recurrence rate was 33%. In patients with at least 12 months follow-up, the size of the aneurysm (p=0.016), the size of the aneurysm neck (p=0.028), and hypertension (p=0.03) were predictive of the likelihood of recurrence. There were 3 major complications (4%). The average size of the aneurysm was greater in patients who experienced a major complication, though this did not reach statistical significance due to the low number of complications. 28 (35%) of the 79 patients presented with a visual disturbance that could be attributed to the aneurysm. Visual disturbances were experienced in those patients with larger aneurysms, though this was not statistically significant (p=0.285). Of the 28 patients with visual disturbance, 46% experienced improvement in their symptoms while none of the 51 patients who presented without visual disturbances developed a visual field defect postoperatively (p > 0.001). Conclusion Endovascular treatment of paraophthalmic internal carotid artery aneurysms appears to be a safe and effective treatment. Major complication rates were found to reside well within the expected rates for intracranial aneurysm treatment. Clinically, almost half of the patients who present with symptomatic visual disturbance or eye pain had significant improvement after treatment, and none of the patients presenting without visual disturbance demonstrated postoperative visual impairment. Disclosures J. Gaughen: 2; C; Covidien. C. Durst: None. Q. Nguyen: None. J. Patrie: None. M. Jensen: 2; C; Covidien, Microvention, Stryker. A. Evans: 2; C; Covidien, Microvention.
Physical Simulation Technology in the Value Guide of Head Processing Application

This paper introduces physical simulation analysis method,through professional finite element analysis software Advantedge value guide on engine cylinder head machining simulation analysis,and apply the analysis results to production,practice has proved,this method in engine value guide processing can increase tool life,improve the production cycle time,has a good production efficiency.
Reversible acid activation of amniotic fluid inactive renin

1. Inactive renin was isolated from human amniotic fluid by chromatography with DEAE-cellulose, pepstatin-aminobutyl-agarose, octylagarose and Cibacron Blue F3GA columns. 2. Before and after isolation from amniotic fluid, inactive renin could be activated by incubation with pepsin and by dialysis to pH 3.3, and the acid activation could be reversed by subsequent incubation at pH 7.4 and 37 degrees C. 3. Inactive renin was not activated by procedures expected to dissociate renin from an inhibitor. 4. The results suggest a pH-dependent conformational change as the mechanism of reversible acid activation of inactive renin in amniotic fluid. 5. There are chromatographic and activation similarities of inactive renin from human plasma, kidney and amniotic fluid.
Transient cholinergic glycoconjugate secretion from swine tracheal submucosal gland cells.

By inference, muscarinic stimulation of glycoconjugate release from tracheal submucosal gland cells appears to be a transient, nonequilibrium process (J. M. Farley and T. M. Dwyer, Life Sci. 48: 59...
Photon-Echo Zeeman Quantum Beats in Cesium Hyperfine Levels

Photon echo quantum beats were first reported by Lambert et al. [1] who observed echo modulations as a function of excitation pulse separation in ruby at low temperature. The modulations in the echo signal arise when a set of nondegenerate levels in the excited or ground state simultaneously participates in the echo process giving rise to interference terms in the coherent oscillating dipole moment. In ruby the quantum beats were attributed to Cr-Al superhyperfine interactions [2]. A semi-classical analysis of the general problem of photon echo quantum beats was given by Lambert, Compaan, and Abella [3], using methods of Gordon et al. [4]. Subsequent theoretical work was doen by Schenzle et al. [5] while observations of echo quantum beats have been reported in NH2D [6] and in cesium vapor [7].
An Integrated Ecological Modeling System for Assessing Impacts of Multiple Stressors on Stream and Riverine Ecosystem Services within River Basins.

Abstract We demonstrate a novel, spatially explicit assessment of the current condition of aquatic ecosystem services, with limited sensitivity analysis for the atmospheric contaminant mercury. The Integrated Ecological Modeling System (IEMS) forecasts water quality and quantity, habitat suitability for aquatic biota, fish biomasses, population densities, productivities, and contamination by methylmercury across headwater watersheds. We applied this IEMS to the Coal River Basin (CRB), West Virginia (USA), an 8-digit hydrologic unit watershed, by simulating a network of 97 stream segments using the SWAT watershed model, a watershed mercury loading model, the WASP water quality model, the PiSCES fish community estimation model, a fish habitat suitability model, the BASS fish community and bioaccumulation model, and an ecoservices post-processer. Model application was facilitated by automated data retrieval and model setup and updated model wrappers and interfaces for data transfers between these models from a prior study. This companion study evaluates baseline predictions of ecoservices provided for 1990–2010 for the population of streams in the CRB and serves as a foundation for future model development.
New insights from a high-resolution look at gastrulation in the sea urchin, Lytechinus variegatus.

Abstract Background Gastrulation is a complex orchestration of movements by cells that are specified early in development. Until now, classical convergent extension was considered to be the main contributor to sea urchin archenteron extension, and the relative contributions of cell divisions were unknown. Active migration of cells along the axis of extension was also not considered as a major factor in invagination. Results Cell transplantations plus live imaging were used to examine endoderm cell morphogenesis during gastrulation at high-resolution in the optically clear sea urchin embryo. The invagination sequence was imaged throughout gastrulation. One of the eight macromeres was replaced by a fluorescently labeled macromere at the 32 cell stage. At gastrulation those patches of fluorescent endoderm cell progeny initially about 4 cells wide, released a column of cells about 2 cells wide early in gastrulation and then often this column narrowed to one cell wide by the end of archenteron lengthening. The primary movement of the column of cells was in the direction of elongation of the archenteron with the narrowing (convergence) occurring as one of the two cells moved ahead of its neighbor. As the column narrowed, the labeled endoderm cells generally remained as a contiguous population of cells, rarely separated by intrusion of a lateral unlabeled cell. This longitudinal cell migration mechanism was assessed quantitatively and accounted for almost 90% of the elongation process. Much of the extension was the contribution of Veg2 endoderm with a minor contribution late in gastrulation by Veg1 endoderm cells. We also analyzed the contribution of cell divisions to elongation. Endoderm cells in Lytechinus variagatus were determined to go through approximately one cell doubling during gastrulation. That doubling occurs without a net increase in cell mass, but the question remained as to whether oriented divisions might contribute to archenteron elongation. We learned that indeed there was a biased orientation of cell divisions along the plane of archenteron elongation, but when the impact of that bias was analyzed quantitatively, it contributed a maximum 15% to the total elongation of the gut. Conclusions The major driver of archenteron elongation in the sea urchin, Lytechinus variagatus, is directed movement of Veg2 endoderm cells as a narrowing column along the plane of elongation. The narrowing occurs as cells in the column converge as they migrate, so that the combination of migration and the angular convergence provide the major component of the lengthening. A minor contributor to elongation is oriented cell divisions that contribute to the lengthening but no more than about 15%.
Low power embedded system for pre-fall detection application

Fall has become a serious medical problem, and sometimes leading to physical disabilities and death. This led researchers to pursue automatic monitoring systems for detecting the falls before they occur. Much of the existing efforts have successfully achieved a hardware system which provides a fall pattern after and prior to the fall. However, the existing fall detection systems are still deficient in achieving power optimization and optimum sensor structures. In this study, we have demonstrated a pre-fall detection system using accelerometers and gyroscopes, associated with EFM32GG — ARM Cortex −M3 based 32-bit microcontroller and MicroSD. The system is designed to get optimal low power consumption, better sensitivity & specificity, and early pre-fall detection, to trigger safety devices. The algorithm enables the system on interrupts, which then calculates angular positons of the subject using motion sensors and combines the result with Signal Vector Magnitude (SVM) and Signal Magnitude Area (SMA) to detect the pre-fall accurately. The system was constructed and tested. The practical model consumes 409.1μA in deep sleep mode and 15mA in the active mode with 92% sensitivity and 98.07% specificity. The system stays in sleeping mode during majority of user activity of daily living (walking, sitting), thus improving the battery life of the device. The system also successfully differentiates between the activity of daily living (ADL) like walking, sitting, running, and climbing stairs with actual fall. This paper details the power optimization and consumption, the sensor system architecture, the software algorithm for pre-fall detection and the low power hardware wireless.
The Entrepreneurial Intellectual in the Corporate University

Clyde Barrow’s critical theoretical monograph, The Entrepreneurial Intellectual in the Corporate University, is timely and probes the structural and historical transformation of the university towa...
Strong cation exchange-reversed phase liquid chromatography-capillary zone electrophoresis-tandem mass spectrometry platform with high peak capacity for deep bottom-up proteomics.

Abstract Two-dimensional (2D) liquid chromatography (LC)-tandem mass spectrometry (MS/MS) are typically employed for deep bottom-up proteomics, and the state-of-the-art 2D-LC-MS/MS has approached over 8000 protein identifications (IDs) from mammalian cell lines or tissues in 1–3 days of mass spectrometer time. Capillary zone electrophoresis (CZE)-MS/MS has been suggested as an alternative to LC-MS/MS for bottom-up proteomics. CZE-MS/MS and LC-MS/MS are complementary in protein/peptide ID from complex proteome digests because CZE and LC are orthogonal for peptide separation. In addition, the migration time of peptides from CZE-MS can be predicted accurately, which is invaluable for evaluating the confidence of peptide ID from the database search and even guiding the database search. However, the number of protein IDs from complex proteomes using CZE-MS/MS is still much lower than the state of the art using 2D-LC-MS/MS. In this work, for the first time, we established a strong cation exchange (SCX)-reversed phase LC (RPLC)-CZE-MS/MS platform for deep bottom-up proteomics. The platform identified around 8200 protein groups and 65,000 unique peptides from a mouse brain proteome digest in 70 h. The data represents the largest bottom-up proteomics dataset using CZE-MS/MS and provides a valuable resource for further improving the tool for prediction of peptide migration time in CZE. The peak capacity of the orthogonal SCX-RPLC-CZE platform was estimated to be around 7000. SCX-RPLC-CZE-MS/MS produced comparable numbers of protein and peptide IDs with 2D-LC-MS/MS (8200 vs. 8900 protein groups, 65,000 vs. 70,000 unique peptides) from the mouse brain proteome digest using comparable instrument time. This is the first time that CZE-MS/MS showed its capability to approach comparable performance to the state-of-the-art 2D-LC-MS/MS for deep proteomic sequencing. SCX-RPLC-CZE-MS/MS and 2D-LC-MS/MS showed good complementarity in protein and peptide IDs and combining those two methods improved the number of protein group and unique peptide IDs by nearly 10% and over 40%, respectively, compared with 2D-LC-MS/MS alone.
Contribution of Neuromuscular Factors to Quadriceps Asymmetry After Anterior Cruciate Ligament Reconstruction

Context: To quantify quadriceps weakness after anterior cruciate ligament reconstruction (ACLR), researchers have often analyzed only peak torque. However, analyzing other characteristics of the waveform, such as the rate of torque development (RTD), time to peak torque (TTP), and central activation ratio (CAR), can lend insight into the underlying neuromuscular factors that regulate torque development. Objective: To determine if interlimb neuromuscular asymmetry was present in patients with ACLR at the time of clearance to return to activity. Design: Cross-sectional study. Setting: Laboratory. Patients or Other Participants: A total of 10 individuals serving as controls (6 men, 4 women; age = 23.50 ± 3.44 years, height = 1.73 ± 0.09 m, mass = 71.79 ± 9.91 kg) and 67 patients with ACLR (43 men, 24 women; age = 21.34 ± 5.73 years, height = 1.74 ± 0.11 m, mass = 77.85 ± 16.03 kg, time postsurgery = 7.52 ± 1.36 months) participated. Main Outcome Measure(s): Isokinetic (60°/s) and isometric quadriceps s...
Na/K-ATPase signaling mediates miR-29b-3p regulation and cardiac fibrosis formation in mice with chronic kidney disease

The Na/K-ATPase is an important membrane ion transporter and a signaling receptor that is essential for maintaining normal cell function. The current study examined the role of Na/K-ATPase signaling in regulating miR-29b-3p, an anti-fibrotic microRNA, in a mouse chronic kidney disease (CKD) model (5/6th partial nephrectomy or PNx). The results showed that CKD induced significant reduction of miR-29b-3p expression in the heart tissue by activation of Src and NFκB signaling in these animals. To demonstrate the role of Na/K-ATPase signaling, we also performed the PNx surgery on Na/K-ATPase α1 heterozygous (α1+/-) mice, which expresses ~40% less Na/K-ATPase α1 compared to their wild type littermates (WT) and exhibits deficiency in Na/K-ATPase signaling. We found that CKD did not significantly change the miR-29b-3p expression in heart tissue from the α1+/- animals. We also found that CKD failed to activate Src and NFκB signaling in these animals. Using isolated cardiac fibroblasts from α1+/- mice and their WT littermates, we showed that ouabain, a specific Na/K-ATPase ligand, induces decreased miR-29b-3p expression in fibroblasts isolated from WT mice, but had no effect in cells from α1+/- mice. Inhibition of NFκB by Bay11-7082 prevented ouabain-induced miR-29b-3p reduction in WT fibroblasts. To further confirm the in vivo effect of Na/K-ATPase signaling in regulation of miR-29b-3p and cardiac fibrosis in CKD animals, we used pNaKtide, a Src inhibiting peptide derived from the sequence of Na/K-ATPase, to block the activation of Na/K-ATPase signaling. The result showed that pNaKtide injection significantly increased miR-29b-3p expression and mitigated the CKD-induced cardiac fibrosis in these animals. These results clearly demonstrated that Na/K-ATPase signaling is an important mediator in CKD that regulates miR-29b-3p expression and cardiac fibrosis, which provides a novel target for regulation of miR-29b-3p in CKD. We also demonstrate that antagonizing Na/K-ATPase signaling by pNaKtide can reduce organ fibrosis through the stimulation of tissue miR-29b-3p expression.
Service-Learning in an Undergraduate Abnormal Psychology Course: What Do Students Learn?

In my Abnormal Psychology course students reported that their service-learning work at mental health related organizations in the community helped them connect course content to life experiences, increase their understanding of the impact of mental illness on people’s lives, and examine their attitudes about people with psychological disorders. They also developed increased empathy, greater understandings of cultural and racial differences, and more awareness of their personal strengths. They felt useful to others, that their service made a difference, and that they were more likely to volunteer in the future. These results are consistent with previous research that service-learners increase their understanding of course content and experience personal growth. The present study provides a more focused perspective on how Abnormal Psychology students are affected specifically by their experiential understanding of psychological disorders and reflection on their attitudes about mental illness.
Later Stages of Boundary-Layer Transition

The need for understanding and predicting the laminar-turbulent transition is imperative in many technologically important situations. The National Aerospace Plane, the Advanced Subsonic Transport, and the High Speed Civil Transport are but a few examples in which the vehicle dynamics are modulated by the transition process. The onset of transition controls whether the flow over an aircraft wing is laminar or turbulent and determines whether the flow will remain attached, become fully separated, or form a separation bubble and reattach. Drag reduction in external or internal flows depends on the detail of the transition process, and efforts to predict heat transfer and to cool the turbulent blades are hampered by lack of a reliable transition scheme. The present chapter discusses boundary-layer transition with emphasis on the incompressible case.
Snow Brand Milk Products (B): Reform and Revitalization Efforts

This case outlines the turnaround efforts Snow Brand undertook to address its grave missteps: consumer-oriented, integrity-focused management style; greater transparency and communication; a corporate ethics committee; and a Snow Brands Code of Conduct. In June 2002, after much consideration and reflection on Snow Brand's issues (as outlined in the A case), consumer activist Nobuko Hiwasa joined SBM’s new board as its sole outside director, serving as the impetus for the changes the company made. Her appointment indicated Snow Brand Milk Products was indeed serious about reform and revitalization.
Raw Materials in the Manufacture of Biotechnology Products

Raw materials are an important aspect in the manufacture of biotechnology products as their quality may critically impact the quality of the finished product and thereby compromise its safety and efficacy.
Equine Coital Exanthema Virus

This chapter provides an overview of the classification and description of the equine coital exanthema virus, its hosts, the key developments regarding the virus, and the diagnostic techniques and reagents. The equine coital exanthema virus causes a venereally transmitted disease characterized by vesicles, pustules, and ulcers on the penis, prepuce of stallions, vagina, vulva, and perineal area of mares. The hosts that are infected by the equine coital exanthema virus include horses. A worldwide distribution for the equine coital exanthema virus is suspected. A microplaque virus neutralization (VN) assay system is the most sensitive diagnostic technique for the equine coital exanthema virus. Complement-fixing (CF) antibodies indicate infection within 60 days.
Investigation of Neuropsychiatric Disorders

The cerebral disorders most likely to have psychiatric consequences in old age are dementia, Parkinson’s disease and stroke.
TRANSCRIPTION PATTERN OF DROSOPHILA MELANOGASTER MITOCHONDRIAL DNA

ABSTRACT The expression of Drosophila melanogaster mitochondrial DNA has been examined by mapping and sizing a set of mitochondrial transcription products present in both tissue culture and larval salivary gland cells. We have utilized five recombinant plasmids containing cDNA complementary to polyadenylated Drosophila salivary gland mitochondrial transcripts as hybridization probes to identify and localize regions of the mitochondrial DNA genome which are transcribed. The sizes of the mitochondrial transcripts generating the cDNA-containing plasmids were determined. The overall pattern of mitochondrial transcription is not remarkably different during the first 21 hours of embryogenesis.
Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.

Summary Dendritic spines influence synapse function by boosting synaptic potentials and sequestering synaptically generated second messengers. Spines have been extensively studied in densely spiny principal neurons, but little is known about how they expand the information-gathering capabilities of sparsely spiny interneurons (INs). We find in the mouse primary visual cortex, parvalbumin-positive INs have a low density of spines that enclose functional glutamatergic synapses. Both spine and dendritic synapses contain calcium-permeable AMPA receptors (CP-AMPARs) and NMDA receptors (NMDARs), but NMDARs are enriched at spine synapses. Glutamate-receptor-mediated Ca influx at proximal dendritic sites is bidirectionally modulated by the timing of action potentials (APs). Surprisingly, spine synapses are largely insensitive to APs, but coincident activity originating in the adjacent dendrite strongly influences spine NMDAR-mediated calcium influx. Thus, while glutamate receptors on spines and dendrites are modulated by the activity of the neuron, they are distinctive in the type of coincident activity detected.
The Growth of Control? Changes in Local Land-Use Regulation in Major U.S. Metropolitan Areas From 1994 to 2003

ABSTRACTAmid concerns that increasingly stringent local land-use regulations are constraining housing development across the United States, there is a need for an empirical investigation into wheth...
Scenario Analysis and Managing Strategic Ambiguity: How to Remember Future Events, Before They Actually Occur!

Scenario analysis deals with strategic uncertainty . It introduces a new way of thinking about problems. We use scenario analysis when we don’t know what will happen next, and when we are facing such strategic ambiguity that we don’t even know what game we are playing. Digital transformations are like that. We don’t know what the rules are. If we’re executives, we don’t know what’s possible, what our customers will want, or what our regulators will permit. We don’t know what our opponents’ strategies will be, or what strategies we should adopt in response. If we’re consumers, we don’t know what to buy, or how to choose, or what the sharing economy of Uber and Airbnb will do for us, or to our neighborhoods. We need a way to figure out what the new rules will be, and what the new strategic choices will be. We need to know what game we are playing. Then, we can develop our strategies, for our businesses and for our lives. Scenario analysis doesn’t start by gathering data. The process starts by identifying questions that will be important and then seeks to determine the data that you will wish you could have to answer those questions.
Reflection on Tacit Knowledge - Effect of Providing EMG Visualization on Reflections on Throwing Clay

Craft practitioners rely on reflection to train and improve their skills. The lack of media to represent and communicate their tacit knowledge makes reflection difficult, especially if this reflection happens after the fact. This paper presents a set-up that tracks and visualizes muscle activities of potters when throwing on the wheel. We use this set-up to investigate the effect of the visualization of potters' muscle activities on their retrospective reflections on their own practice. We conducted a preliminary user study with three expert potters. The preliminary results suggest that externalizing the once implicit muscle activities alters potters' reflection of their own practice and can potentially serve as a medium to communicate the tacit knowledge involved in throwing.
Gender Differences in Patients with Panic Disorder: Evaluating Cognitive Mediation of Phobic Avoidance

Epidemiologic reports have consistently found that females are at greater risk for the development of panic disorder, in particular, when it is accompanied by agoraphobia. Although gender appears to be a well-established risk factor for the development of phobic avoidance, the mechanisms that account for this increased risk have yet to be delineated. Often, gender differences in phobic avoidance are speculated to arise from differences in courage (e.g., men are expected to be brave and endure fear-provoking situations). Our study evaluated this popular but unsubstantiated theory and advanced another hypothesis: Differences in panic- and arousal-related cognitions may account for gender differences in phobic avoidance. Male (n = 27) and female (n = 61) patients meeting DSM-IV criteria for panic disorder with or without agoraphobia were evaluated. Data did not support gender differences in courage; nor were these indices related to phobic avoidance. In contrast, there were significant gender differences in several cognitive domains. Moreover, anxiety sensitivity and panic-related appraisals mediated gender differences in phobic avoidance.
Diffusion flames in a chamber

Gaseous fuel is injected at a constant rate M from the bottom of a narrow insulated chamber and oxidant diffuses from the top. The object is to determine the response curve, i.e. the unburnt fuel fraction R as a function of M for fixed Damkohler number (representing either the constant chamber pressure or the chamber's length). The conclusions we draw are based on activation-energy asymptotics. Explicit response curves are obtained over the whole range of D. Two critical values Da, D0 are uncovered and determined explicitly. If D D0 the response is 5-shaped: the top of the curve lies on R = 1 and extends to M → ∞; the bottom lies on R = 0 and persists however small M becomes. The isola has two extinction points, corresponding to the fuel being supplied too slowly or too fast to a flame at the bottom or top of the chamber. The S has just the latter, but also has an ignition point; as M is decreased through the corresponding value the flame suddenly appears. The asymptotic analysis completes the inadequate picture obtained previously by numerical methods. It spans the whole range of parameter values and enables explicit formulas to be written for the ignition and extinction points.
Infant rats can acquire, but not retain contextual associations in object-in-context and contextual fear conditioning paradigms.

Context learning in postnatal day (PD) 16-18 rats has been taken by Revillo, Cotella, Paglini, and Arias (2015, Physiology & Behavior, 148, 6-21) to challenge the view that the ontogeny of contextual learning is related to the development of the hippocampal system (Rudy, 1993, Behavioral Neuroscience, 107(5), 887-891; Schiffino, Murawski, Rosen, & Stanton, 2011 Neurobiology of Learning and Memory, 95(2), 190-198). Whether context learning is "incidental" or "reinforcement-driven" may determine the ontogeny and neural systems involved (Rudy, 2009, Learning & Memory (Cold Spring Harbor, N.Y.), 16, 573-585). However, we have shown differential ontogeny of two different forms of incidental context learning, the context pre-exposure facilitation effect (CPFE; Jablonski, Schiffino, & Stanton, 2012, Developmental Psychobiology, 54(7), 714-722), which emerges between PD 17 and 21; and object-in-context recognition (OiC, Ramsaran, Westbrook, & Stanton, 2016, Developmental Psychobiology, 58(7), 883-895; Ramsaran, Sanders, & Stanton, 2016, Behavioural Brain Research, 298, 37-47), which is present on PD17. We investigated whether this task-dissociation reflects an encoding or a retention deficit, by varying the sample-to-testing intervals for both tasks. Experiment 1A found that PD17 rats were able to perform the OiC task after short (5 min) but not long (24 hr) sample-to-test intervals. Experiments 1B and 1C found that PD17 rats trained on the CPFE are able to acquire and express context-shock associations after short but not long retention intervals. These findings suggest that pre-weanling rats encode contexts but show poor consolidation or retrieval after longer retention intervals.
Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis

Neurotoxicity is a rare side effect of Cefepime use. Cefepime can cross the blood-brain barrier and can be neurotoxic by competitive albeit weak antagonism of the gamma-aminobutyric acid complex. It is cleared by the kidneys which puts individuals with renal impairment at risk of side effects. We describe a case of Cefepime neurotoxicity in the context of nephrotoxicity secondary to the use of other drugs.