cssi/SciSciGPT-SciSciNet huggingface dataset:
Multiple Myeloma and Treatment-Related Thromboembolism: Oncology Nurses' Role in Prevention, Assessment, and Diagnosis

Immunomodulating agents such as thalidomide and its newly emerged derivative, lenalidomide, are becoming increasingly popular in the treatment of multiple myeloma because of their ability to combat drug resistance. Clinical trials suggest that thalidomide and lenalidomide are effective in all stages of multiple myeloma treatment-new diagnoses, stem cell transplantations, maintenance therapy, and relapsed or refractory disease. The drugs are most efficacious when combined with additional chemotherapeutic agents and/or corticosteroids. However, deep vein thrombosis and other thromboembolic events are associated with the treatment regimens. Oncology nurses must understand the pharmacologic properties of the drugs and the potentially life-threatening complications associated with them. To provide the highest standard of care, oncology nurses must play a vital role in the prevention, diagnosis, and management of thromboembolic events through awareness of the clinical problem, assessment tools, and thromboembolic prophylactic regimens.
Hydrodynamic interaction of spherical aerosol particles in a high intensity acoustic field

The hydrodynamic interaction between micron-sized aerosol particles dispersed in a gas with a high intensity acoustic field is analyzed. The particles are assumed to be much smaller than the acoustic boundary layer thickness, and to have a much larger density than the gas. Flow Reynolds numbers of the particles is in the range 0 to 10. In the calculation scheme the superposition method is used. Results show fairly strong hydrodynamic interaction velocities for close particle separations. These interaction velocities could be a major factor in the fill-up of the agglomeration volume during acoustic agglomeration.
A test of visual responses in the newborn.

SUMMARY A rapid easy bedside test for evaluation of visual responsiveness in newborn infants is described. It proved more efficient in eliciting fixation and following than a bright red ball or diffuse daylight. RESUME Un test de reponse visuelle chez le nouveau-ne Un test rapide, facile, au lit du malade, pour l'evaluation des reponses visuelles chez le nouveau-ne est decrit. Il s'est reavele plus efficace dans la fixation et la poursuite qu'une balle rouge brillante ou une lumibre du jour diffuse.
In utero evaluation of velocardiofacial syndrome

Abstract Velocardiofacial syndrome (VCF) and other 22q11.2 deletion phenotypes can be diagnosed in utero by fluorescence in situ hybridization (FISH) of metaphase or interphase chromosomes from fetal cells obtained at 10–12 weeks by chorionic villus sampling or after 12 weeks by amniocentesis. Definite indications for prenatal testing are a family history of VCF or a 22q11.2 deletion, or ultrasound findings of a conotruncal cardiac defect. Other ultrasound findings reported with, but not specific to the 22q11.2 deletion, are: renal anomaly, polyhydramnios and, in the 10–12 week fetus, increased nuchal translucency. Further, evaluation of the fetus with confirmed or suspected 22q11.2 deletion includes karyotype, comprehensive initial and sequential ultrasounds and echocardiograms including a postnatal echocardiogram, as well as parental testing by FISH. If a deletion is identified, the family should be counseled by a multidisciplinary medical team knowledgeable about the spectrum of clinical features as well as the limitations of prenatal testing for the 22q11.2 deletion. With antenatal diagnosis of VCF or other 22q11.2 deletion syndromes, the parents can make an informed reproductive decision and plan for the current and subsequent pregnancies.
Modernity and childrearing in families of Gujarati Indian adolescents

Over the last two decades, researchers have devoted increasing attention to the role of cognitive factors in parenting. These cognitive mediational models focus on the role of attitudes, beliefs, and knowledge in influencing parenting behaviours. A cognitive factor that contributes to cultural variation in parenting is attitudinal modernity--a broad concept that refers to the "Westernization" of attitudes in such diverse areas as gender role conceptions, political attitudes, attitudes toward authority, the family, and religious beliefs. Modernity has been most useful in describing the attitudes of individuals from countries undergoing the rapid social and economic changes that accompany industrialism and urbanization. The present study focused on India--a country currently undergoing such changes. Despite the wide range of modern and traditional beliefs among contemporary Indian parents, our understanding of the determinants of these individual differences is limited. The purpose of the present study was ...
Inverse electron demand diels-alder reactions of 3-carbomethoxy-2-pyrones. Controlled introduction of oxygenated aromatics: benzene, phenol, catechol, resorcinol, pyrogallol annulation.

Abstract Implementation of one of four inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones with N-vinyl-2-pyrrolidinone, vinylene carbonate, 1,1-dimethoxyethylene or 1,1,2-trimethoxyethylene followed by choice of two standard reaction sequences: (1) removal of the carbomethoxy group (NaOH; copper powder, quinoline, Δ) or (2) its conversion to an acetate [NaOH: (CO)2Cl2: (CH3)2CuLi: m-CPBA] allows the preparation of a full range of oxygen substituted aromatics from a single intermediate and represent methods of benzene, 1-, 2- or 3-phenol, symmetrical or unsymmetrical catechol, resorcinol and pyrogallol annulation.
Recognition of speech under stress and in noise

Speech recognizers trained in one condition but operating in a different condition degrade in performance. Typical of this situation is when the recognizer is trained under normal conditions but operated in a stressful and noisy environment as in military applications. This paper reports on recognition experiments conducted with a "simulated stress" data base using a baseline algorithm and its modifications. These algorithms perform acceptably well (1 % substitution rate) for a vocabulary of 105 words under normal conditions, but degrade by an order of magnitude under the "stress" conditions. The experiments also show that the speech production variation caused by noise exposure at the ear is far more deleterious than ambient acoustic noise with a noise cancelling microphone.
ADIABATIC APPROXIMATION AND NECESSARY CONDITIONS FOR THE EXISTENCE OF BOUND STATES.

Let $H(\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\rho}}, \stackrel{\ensuremath{\rightarrow}}{\mathrm{r}})$ represent the ($M\ensuremath{-}1$)-body Hamiltonian that results from fixing the center of mass $\stackrel{\ensuremath{\rightarrow}}{\mathrm{R}}$ of an $M$-body system, where $\stackrel{\ensuremath{\rightarrow}}{\mathrm{r}}$ is the relative coordinate of a particular pair of particles, and $\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\rho}}$ represents the $M\ensuremath{-}2$ remaining internal coordinates. With ${E}_{\mathrm{thr}}$ the lowest continuum threshold associated with $H$, the number of bound states of the system is the number of negative eigenvalues of $H\ensuremath{-}{E}_{\mathrm{thr}}$. A simple lower bound on $H$ was derived by Hahn and Spruch through the use of an adiabatic-like approximation in which the ($M\ensuremath{-}1$)-body problem is attacked by considering first an ($M\ensuremath{-}2$)-body problem and then a one-body problem. With ${E}_{\mathrm{a}0}(\mathcal{r})$ the lowest energy of the system for $\stackrel{\ensuremath{\rightarrow}}{\mathrm{R}}$ and $\stackrel{\ensuremath{\rightarrow}}{\mathrm{r}}$ fixed, one finds $H(\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\rho}}, \stackrel{\ensuremath{\rightarrow}}{\mathrm{r}})\ensuremath{-}{E}_{\mathrm{thr}}g~\stackrel{^}{1}(\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\rho}}){H}^{(1)}(\stackrel{\ensuremath{\rightarrow}}{\mathrm{r}}), \mathrm{where} {H}^{(1)}\ensuremath{\equiv}{T}_{\stackrel{\ensuremath{\rightarrow}}{\mathrm{r}}}+{E}_{\mathrm{a}0}(\mathcal{r})\ensuremath{-}{E}_{\mathrm{thr}}\ensuremath{\equiv}{T}_{\stackrel{\ensuremath{\rightarrow}}{\mathrm{r}}}+{V}^{(1)}(\mathcal{r}).$ ${H}^{(1)}$ is a one-body Hamiltonian, ${T}_{\stackrel{\ensuremath{\rightarrow}}{\mathrm{r}}}$ is the kinetic energy operator for the relative motion of the particular pair, and $\stackrel{^}{1}(\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\rho}})$ is the unit operator in the space of quadratically integrable functions of $\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\rho}}$. The adiabatic potential ${E}_{\mathrm{a}0}(\stackrel{\ifmmode \dot{}\else \.{}\fi{}}{\mathcal{r}})$ has been tabulated for a number of systems, primarily atomic and molecular. A necessary condition for the existence of a bound state of $H$ is that the lowest eigenvalue of ${H}^{(1)}$ be negative.The method is formulated fairly generally and discussed in some detail for the case of Coulomb interactions. It is shown that neither He+${e}^{+}$ nor $\ensuremath{\alpha}+p+{e}^{\ensuremath{-}}$ can form bound states. We also find lower bounds of -0.068 and -0.065 eV on the energy of the ground state and the first excited state, respectively, of the H+${e}^{+}$ system; presumably there is no bound state of this system, but we are unable to prove it. The system H+${e}^{\ensuremath{-}}$ is also considered.
A novel CPU/GPU simulation environment for large-scale biologically realistic neural modeling.

Computational Neuroscience is an emerging field that provides unique opportunities to study complex brain structures through realistic neural simulations. However, as biological details are added to models, the execution time for the simulation becomes longer. Graphics Processing Units (GPUs) are now being utilized to accelerate simulations due to their ability to perform computations in parallel. As such, they have shown significant improvement in execution time compared to Central Processing Units (CPUs). Most neural simulators utilize either multiple CPUs or a single GPU for better performance, but still show limitations in execution time when biological details are not sacrificed. Therefore, we present a novel CPU/GPU simulation environment for large-scale biological networks, the NeoCortical Simulator version 6 (NCS6). NCS6 is a free, open-source, parallelizable, and scalable simula- tor, designed to run on clusters of multiple machines, potentially with high performance computing devices in each of them. It has built-in leaky-integrate-and-fire (LIF) and Izhikevich (IZH) neuron models, but users also have the capability to design their own plug-in interface for different neuron types as desired. NCS6 is currently able to simulate one million cells and 100 million synapses in quasi real time by distributing data across these heterogeneous clusters of CPUs and GPUs.
In Situ Synchrotron X-ray Powder Diffraction Studies of Crystallization of Microporous Aluminophosphates and Me2+-Substituted Aluminophosphates

In situ synchrotron X-ray powder diffraction was used to study the crystallization of microporous aluminophosphate and of Mg2+-, Mn2+-, Co2+-, and Zn2+-substituted aluminophosphates. The gels contained the templates 2-(diethylamino)ethanol, di-n-propylamine, triethylamine, and tripropylamine and were heated in quartz glass capillaries at temperatures up to 200 °C. The main crystalline reaction products formed were AlPO4 (tridymite type), APO-5 (AFI), APO-11 (AEL), MgAPO-5 (AFI), MnAPO-5 (AFI), CoAPO-5 (AFI), ZnAPO-39 (ATN), and ZnAPO-47 (CHA). A kinetic analysis of the crystallization of MnAPO-5 (AFI) and ZnAPO-47 (CHA) was performed using isothermal in situ synchrotron X-ray powder diffraction data. The apparent activation energies for the hydrothermal nucleation of MnAPO-5 (AFI) and ZnAPO-47 (CHA) were 161(6) and 112(3) kJ/mol, respectively. The crystallization of MnAPO-5 could be modeled using a first-order expression giving an apparent activation energy of the crystal growth of 81(6) kJ/mol. The cryst...
Bioavailability and crop uptake of trace elements in soil columns amended with sewage sludge products

In order to assess the potential impact of long-term sewage sludge application on soil health, the equivalent of about 25 years of agronomic applications of low-metal (`EQ') sewage sludge products were made to greenhouse soil columns. After a 6-year period of `equilibration', during which time successive crops were grown with irrigation by simulated acid rain, the plant-available quantities of trace elements were estimated in the soils by extraction with 0.01 M CaCl2 at 90 °C, and measured directly by uptake into a crop of red clover (Trifolium pratense L.). Soil pH had a strong influence on the level of extractable and plant-available metals, and because the tested sludge products affected soil pH differently, pH was directly factored into the comparison of different sludge treatments with controls. CaCl2-extractable levels of several metals (Cu, Zn, Mo), sulfur and phosphorus were found to be higher in the soils amended with organic-rich sludge products than in the control soils. However, extractable Cd and Ni were not significantly elevated by the sludge amendments, presumably because of the low total loading of these metals. Copper, Zn and Mo applied in the form of sludge ash had low soil extractability, suggesting that these trace metals were trapped in high-temperature mineral phases formed during sludge incineration, and resisted subsequent weathering in the soil environment. Extractable soil metals in the alkaline-stabilized sludge treatment were also generally low. Phytotoxicity from the sludge metal loadings (Zn≤125, Cu≤135 kg/ha), was not clearly indicated as long as soil pH was maintained in the 6–7 range by lime amendment. Nevertheless, unexplained depressions in yield were noted with some of the sludge products applied, particularly the dewatered and composted materials. On limed soil columns, the most consistent effect of sludge product amendment on red clover composition was a marked increase in plant Mo.
Endophthalmitis following open-globe injuries

The incidence of traumatic endophthalmitis may be decreasing due to earlier wound closure and prompt initiation of antibiotics. Risk factors for endophthalmitis include retained intraocular foreign body, rural setting of injury, disruption of the crystalline lens, and a delay in primary wound closure. The microbiology in the post-traumatic setting includes a higher frequency of virulent organisms such as Bacillus species. Recognizing early clinical signs of endophthalmitis, including pain, hypopyon, vitritis, or retinal periphlebitis may prompt early treatment with intravitreal antibiotics. Prophylaxis of endophthalmitis in high-risk open-globe injuries may include systemic broad-spectrum antibiotics, topical antibiotics, and intravitreal antibiotics to cover both Gram-positive and Gram-negative bacteria. For clinically diagnosed post-traumatic endophthalmitis, intravitreal vancomycin, and ceftazidime are routinely used. Concurrent retinal detachment with endophthalmitis can be successfully managed with vitrectomy and use of intravitreal antibiotics along with a long acting gas or silicone oil tamponade. Endophthalmitis is a visually significant complication of open-globe injuries but early wound closure as well as comprehensive prophylactic antibiotic treatment at the time of injury repair may improve visual acuity outcomes.
Prediction of the flight acceleration of a spacecraft in the boost configuration.

Prediction of flight transient torsional acceleration at base of Surveyor spacecraft and implementation of pulse qualification testing
User Reaction to the Integration of Real & Virtual Worlds; Implications for Virtual World Platforms

Do users of a virtual world want to integrate their real world social network with the virtual world? On the one hand, such integration might improve the utility of the virtual world by allowing users to leverage their pre-existing social networks. On the other hand, such integration might negate the disinhibition-related benefits associated with anonymity in the virtual world. Using a unique dataset of prospective and current user activities in a social 3D virtual world, we study the influence of Facebook Platform integration on a virtual world through its impact on new user registration, time spent in the virtual world, and the social link formation. We find that providing the option to integrate with Facebook reduces new user registration, and that those who choose to integrate spend less time in the virtual world and have difficulty connecting socially with those who have not also chosen to integrate. These results suggest that users do not want to integrate their real and virtual worlds, and that it ...
Monkey kings make havoc: iconoclasm and murder in the Chinese cultural revolution

Abstract This article explores the interplay between destruction of material icons and people during China's Great Proletarian Cultural Revolution (1966–1976), when authority figures—teachers, landlords, monks and nuns, bosses, intellectuals, doctors, Party leaders—were ‘struggled against’ by gangs of teenage revolutionaries called Red Guards. There is striking continuity in the rhetoric and the symbolic practices of the Red Guards as they destroyed statues and to a lesser extent, signs, buildings, and books, and as they killed people. Through techniques of demonisation—the affixing of negative iconic values—the rhetoric of destruction moved all too easily from image to body and from body to image. Yet just as iconoclasm is not always the utter annihilation of an iconic object but, more crucially, an attack on its iconicity, the violence against living people which tends to accompany iconoclastic movements often seems to be about stripping away the external signs of identity and then redefining the boundaries between categories of bodies. After a brief survey of four phases of Communist iconoclasm in China, I explore a number of aspects of Chinese iconoclasm which blur the distinctions between icons and bodies, related to conceptions of icons as living, the production of iconic bodies, and the ‘iconoclasm of the habitus.’ These themes are explored in commentary on two products of Cultural Revolution iconoclasm: Born Red, a memoir by Gao Yuan, and Qiao Dianyun's short story ‘The Blank Stele.’
Changes in paleocurrents during the development of an obliquely convergent plate boundary (Sulaiman fold-belt, southwestern Himalayas, west-central Pakistan)

Abstract Pre-orogenic Cretaceous shelf sandstones at the northern and southern ends of the Sulaiman Range in west-central Pakistan show basically westward dispersal, which is off the craton. However, Paleocene marine sandstones in the south spread east-southeast, and early Eocene deltaic sandstones in the north spread southeast and north. These are mostly onto the craton, and indicate slope reversal of the Cretaceous shelf. Post-Oligocene fluvial molasse shows mostly southward drainage. A 3852 m section of molasse in the northern Sulaiman Range comprises a lower 2378 m of claystones and upwardly fining sandstones that represent meandering rivers and an upper 1474 m that are dominated by conglomerates that represent gravelly braided rivers. Paleocurrents in the lower, meandering, part of the section were generally southward, but very variable, whereas those in the upper, braided, part were more uniform and show eastward flow. A 3146 m section of molasse in the southern Sulaiman Range comprises (1) a basal 1160 m sequence of claystones and sandstones (meandering streams with very diverse flow directions, overall to the southwest), (2) a middle 1603 m sequence dominated by pebbly sandstone with large bedforms (big sandy braided rivers with less diverse flow to the southwest), and (3) an upper 383 m conglomeratic sequence (gravelly braided streams that still flow uniformly southwest). Rivers in the early molasse paralleled the modern Sulaiman Range in the north and flowed obliquely into it in the south, which suggests no uplift of the modern front of the range until the onset of modern transverse (eastward) drainage and the associated influx of conglomerates. In present and admittedly uncertain lithostratigraphic terms, uplift of the modern front of the range apparently began about 700 m lower in the north than in the south. The northern and southern molasse sections otherwise show broadly similar histories of river development.
Are You Ready for the Change? Embracing the Neonatal Resuscitation Program Guidelines of Simulation and Debrief

Poster Presentation Purpose for the Program Change is an inevitable, ongoing process in the healthcare profession. When significant practice changes occur, opportunities present for nursing leaders to champion innovative methods for overall performance improvement. The Neonatal Resuscitation Program (NRP) has offered a standardized approach to the teaching and practice of neonatal resuscitation since 1987. This program has more than 27,000 instructors who train more than three million healthcare providers. NRP guidelines were updated in 2010 through evidence‐based practice that revealed a need for new teaching methods. Two labor and delivery nurses recognized the chance to revamp the way NRP was taught within their level III tertiary facility. Proposed Change Traditionally, NRP instructors have conducted classes through a lecture, video, testing format, followed by a megacode to practice skills. The current changes by the American Academy of Pediatrics to the NRP guidelines have brought about a new education methodology. Instructors need to shift their roles from teachers to facilitators; which requires new skills for successful education. Each instructor previously had his/her own style of teaching, emphasized different points of NRP, and held megacodes that did not always offer the most effective cognitive, technical, and behavioral skills necessary for newborn resuscitation. The proposed change includes standardizing two to three scenarios of infant resuscitation, practicing together as an instructor group, and learning how to be less of a teacher and more of a facilitator so that participants will assume more of the responsibility for their own learning. Implementation, Outcomes, and Evaluation Initially, three standardized resuscitation scenarios were created. Next, a workshop for all unit NRP instructors was scheduled. Instructors were able to practice together and learn how to become effective facilitators of education. Proposed outcomes include successfully bringing current NRP instructors together, establish momentum for change, refocus on the fundamentals of neonatal resuscitation, increase the challenge for participants by their biennial NRP experience, and ultimately optimize improvements in the acquisition of improved performance in neonatal resuscitation. Staff and participants will be surveyed regarding their experience in this updated learning format. Implications for Nursing Practice The main goals for nurses are to create a consistent learning atmosphere, equally stimulating for all participants, led by a core group of instructors. The instructors use adult learning methods to optimize improved performance in neonatal resuscitation, which promotes safe, reliable practice. Finally, the program empowers program participants to champion excellence in the care of newborns.
Immunochemical relatedness of fungal NADPH-cytochrome P-450 reductases and their ability to reconstitute pisatin demethylase activity

Abstract NADPH-cytochromeP-450 reductase was purified from isolate T9 of the pathogenic fungusNectria haematococca, whose virulence onPisum sativum is due in part to its ability to metabolize and detoxify the pea phytoalexin pisatin via a cytochromeP-450-dependent demethylation. Polyclonal antibodies specific for the reductase were prepared and used to help compare this reductase with the corresponding enzyme from a range of other fungi, including plant pathogenic and nonpathogenic ascomycetes, a basidiomycete, and an oomycete. Some similarities were detected in the reductases from all eight ascomycete species examined and even from the oomycetePythium coloratum, whereas Western blots were able to distinguish differences among some filamentous ascomycetes. The ability to participate in pisatin demethylation in a reconstituted system differed strongly among the reductases, but also extended as far as the reductase fromP. coloratum.
Thermal boundary layers over a shrinking sheet: an analytical solution

In this paper, the heat transfer over a shrinking sheet with mass transfer is studied. The flow is induced by a sheet shrinking with a linear velocity distribution from the slot. The fluid flow solution given by previous researchers is an exact solution of the whole Navier–Stokes equations. By ignoring the viscous dissipation terms, exact analytical solutions of the boundary layer energy equation were obtained for two cases including a prescribed power-law wall temperature case and a prescribed power-law wall heat flux case. The solutions were expressed by Kummer’s function. Closed-form solutions were found and presented for some special parameters. The effects of the Prandtl number, the wall mass transfer parameter, the power index on the wall heat flux, the wall temperature, and the temperature distribution in the fluids were investigated. The heat transfer problem for the algebraically decaying flow over a shrinking sheet was also studied and compared with the exponentially decaying flow profiles. It was found that the heat transfer over a shrinking sheet was significantly different from that of a stretching surface. Interesting and complicated heat transfer characteristics were observed for a positive power index value for both power-law wall temperature and power-law wall heat flux cases. Some solutions involving negative temperature values were observed and these solutions may not physically exist in a real word.
Measurement of the Be-7 (p, gamma) B-8 Reaction Cross Section at Low Energies

The absolute total cross section for the reaction $^{7}\mathrm{Be}(p, \ensuremath{\gamma})^{8}\mathrm{B}$ has been measured for ${E}_{\mathrm{c}.\mathrm{m}.}=117\ensuremath{-}1230$ keV by detecting the delayed $\ensuremath{\alpha}$ particles following the $^{8}\mathrm{B}$ $\ensuremath{\beta}$ decay. Two independent methods have been used to determine the areal density of the $^{7}\mathrm{Be}$ target. The inferred zero-energy $S$ factor from the present experiment is ${S}_{17}(0)=0.0216\ifmmode\pm\else\textpm\fi{}0.0025$ keV b. This value reduces the predicted $^{37}\mathrm{Cl}$ solar-neutrino capture rate by \ensuremath{\sim}25%.
Organic reactions at high pressure. A mild method for the placement of protecting groups on hindered and sensitive alcohols

Abstract A series of hindered and/or labile alcohols has been derivatized with a variety of acylating and silylating agents using pyridine in methylene chloride at 15 kbar (1.5 GPa) pressure to afford excellent yields of protected alcohols at 20 °C, largely without the need for added DMAP. Methoxyethoxymethyl chloride reacted in moderate yield using N,N -diisopropylethylamine under the high pressure conditions.
cDNAs encoding the large subunit of human replication factor C

Replication factor C (RFC) is a multisubunit, DNA polymerase accessory protein required for the coordinated synthesis of both DNA strands during simian virus 40 DNA replication in vitro. Previous studies have shown that RFC is a DNA-dependent ATPase that binds in a structure-specific manner to the 3' end of a primer hybridized to a template DNA, an activity thought intrinsic to the 140-kDa component of this multisubunit complex. Here, the isolation and analysis of cDNAs encoding this subunit is described. Analysis of the full-length coding sequence revealed an open reading frame of 3.4 kb, encoding an 1148-amino acid protein with a predicted molecular mass of 130 kDa. A putative ATP-binding motif was observed that is similar to a motif in several of the smaller subunits of RFC and in functionally homologous replication factors of bacterial and viral origin. A "DEAD" box is also conserved among these proteins. The predicted protein shows significant identity with a DNA-binding protein of murine origin (B. Luckow, P. Lichter, and G. Schutz, personal communication). Regions of similarity were also seen between the amino acid sequences of the 140-kDa subunit of RFC, poly(ADP-ribose) polymerase, and bacterial DNA ligases--possibly representing a conserved structural feature of these proteins that bind similar DNA substrates.
Brawny vs. Wimpy: Evaluation and Analysis of Modern Workloads on Heterogeneous Processors

Heterogeneous processors, consisting of a mix of high-performance 'brawny' processors and low-power 'wimpy' processors, have been proposed to achieve higher energy-efficiency by making it possible for different applications within a diverse mix of workloads to be run on the most appropriate cores. This paper performs a comparative analysis of such heterogeneous multicores on the performance and energy efficiency of mobile devices and server systems. Using several real-world workloads from both mobile and enterprise domain, experimental evaluations are carried out on a unique experimental test bed comprised of real heterogeneous CPUs that differ in both their core architecture and cache sizes, comparing the performance and efficiency for these applications. Results show that heterogeneous processors can improve the performance and energy-efficiency for these diverse applications. They also highlight the challenges associated with user-perceived performance on mobile devices and power overhead of shared system components on the energy-efficiency of heterogeneous cores and thus call for novel energy-aware resource management approaches. The experimental results presented in this paper provide platform and system software designers a perspective on the trade-offs involved with these architectures and thus make optimal design choices.
Efficacy of dietary therapy for juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy (JME) is often successfully managed with anticonvulsants; however, some patients may have medically resistant seizures. The modified Atkins diet (MAD) has been reported as effective for idiopathic generalized epilepsy and is increasingly being used in adolescents and adults. Since 2006, 8 adolescents and adults have been started on the MAD for JME at Johns Hopkins Hospital. Of these 8 patients, 6 (75%) were female, with a mean age at seizure onset of 10.5 years (range: 6-13 years) and 24.3 years (range: 15-44 years) at MAD initiation. After 1 month, 6 (75%) patients had >50% seizure reduction, and after 3 months, 5 (63%) patients had >50% improvement. Several patients found the MAD difficult to adhere to, including 3 patients who reported temporarily increased seizures during periods of noncompliance. In this limited experience, the modified Atkins diet was an efficacious adjunctive therapy for young adults with very medically resistant JME.
Effect of cervical spinal cord hemisection and hemidiaphragm paralysis on arterial blood gases, pH, and respiratory rate in the adult rat

We documented the changes that occur in arterial blood gases, pH, and respiratory rate in rats subjected to a C2 spinal cord hemisection which results in paralysis of the ipsilateral hemidiaphragm. The results indicated that rats compensate for hemidiaphragm paralysis by maintaining arterial pO2 through an increased rate of respiration. This observation is of interest because it implies a form of functional recovery from spinal cord injury which has heretofore not been demonstrated.
American Society of Regional Anesthesia and Pain Medicine checklist for managing local anesthetic systemic toxicity: 2012 version.

The American Society of Regional Anesthesia and Pain Medicine (ASRA) periodically revises and updates its checklist for the management of local anesthetic systemic toxicity. The 2017 update replaces the 2012 version and reflects new information contained in the third ASRA Practice Advisory on Local Anesthetic Systemic Toxicity. Electronic copies of the ASRA checklist can be downloaded from the ASRA Web site (www.asra.com) for inclusion in local anesthetic toxicity rescue kits or perioperative checklist repositories.
Competitive DRL performance in humans: Differential reinforcement of short poststimulus pausing

Pairs of human subjects were trained to press a lever according to 5-sec and 12-sec DRL reinforcement schedules. Subjects initially responded independently of one another during baseline sessions and then competed against one another on the same schedule parameters. Results indicated that poststimulus pause durations during competitive sessions were shorter and more closely approximated the schedule value than did poststimulus pause durations under independent conditions. Competition as a means of establishing optimal sensitivity to schedule requirements is discussed.
A NOTE ON THE FATE OF TARTRATES IN THE BODY

Under the experimental conditions outlined, sodium tartrate subcutaneously introduced into rabbits fails to reappear in the urine. It is concluded that the disintegrative influence of the salt upon the convoluted tubules is sufficient to account for the failure of the salt to be eliminated. No evidence of a vicarious function on the part of the glomerulus was observed.
Intralaminar Damage Model for Laminates Subjected to Membrane and Flexural Deformations

Prediction of transverse damage initiation and evolution for not necessarily symmetric laminates under membrane and/or bending loads is the subject of this work. The laminate stiffness reduction is computed via crack opening displacement (COD) methods and the generalization to multiple cracking laminas is made via continuum damage mechanics (CDM) concepts. Using available COD solutions combined with homogenization techniques leads to an analytical constitutive model capable of predicting the initiation and evolution of crack density versus applied strain, as well as laminate modulus degradation, not only for symmetric laminates subjected to membrane deformation but also for general laminates subjected to flexural deformations as well. To adjust the model parameters, experimental data is required in the form of crack density, or modulus reduction, versus strain for two laminates of the same material system. Then, the model is capable of predicting crack density and modulus degradation for other laminate st...
Transport, radiative, and dynamical effects of the antarctic ozone hole: A GFDL SKYHI' model experiment

Abstract The GFDL “SKYHI” general circulation model has been used to simulate the effect of the Antarctic “ozone hole” phenomenon on the radiative and dynamical environment of the lower stratosphere. Both the polar ozone destruction and photochemical restoration chemistries are calculated by parameterized simplifications of the still somewhat uncertain chemical processes. The modeled total column ozone depletions are near 25% in spring over Antarctica, with 1% depletion reaching equatorial latitudes by the end of the 4½–year model experiment. In the lower stratosphere, ozone reductions of 5% reach to the equator. Large coolings of about 8 K are simulated in the lower stratosphere over Antarctica in late spring, while a general cooling of about 1–1.5 K is present throughout the Southern Hemisphere lower stratosphere. The model atmosphere experiences a long-term positive temperature-chemical feedback because significant ozone reductions carry over into the next winter. The overall temperature response to th...
Nonoperative Management of Isolated Celiac and Superior Mesenteric Artery Dissection: Case Report and Review of the Literature

Isolated dissection of the origin of both celiac and superior mesenteric arteries is a rare vascular pathology with limited management guidelines. The presentation is generally nonspecific, most often manifesting with epigastric pain radiating to the back. A high diagnostic index of suspicion and stepwise management are essential for a successful outcome. This case report details the clinical course of a 57-year-male who presented with a 2-week history of epigastric discomfort with back pain and was found to have focal celiac artery dissection with aneurysmal dilation of 1.2 cm. His vital signs were stable, and the physical examination was unremarkable. At this time, he was placed on antiplatelet medication and was scheduled for endovascular repair of his celiac aneurysm with a covered stent graft. Two weeks later, recurrent abdominal pain prompted a repeat computed tomographic scan that revealed sequential superior mesenteric artery (SMA) dissection. The patient was admitted and anticoagulated. A complete workup ruled out underlying collagen vascular and autoimmune pathology. He remained stable, with significant symptomatic improvement. After 6 months, anticoagulation was discontinued and antiplatelet therapy was instituted for long-term management. Subsequent operative or endovascular intervention was not required. The patient was continuing to do well on his 18-month clinical follow-up. There are 71 cases of SMA and 12 cases of celiac artery dissection in the literature. This report outlines this rare presentation of isolated, proximal sequential celiac artery and SMA dissection. This case illustrates that conservative management may be warranted in uncomplicated, isolated visceral arterial dissection.
The relativistic Hartree calculation of deformed nuclei

The Hartree calculation of even-even and N=Z deformed nuclei (16<A<40) are performed in the relativistic quantum field theory framework, using the same parameters as for nuclear matter and spherical nuclei. We found the deformed nuclei are less deformed than the experimental values, and the tensor couplings of the vector-meson can improve the results very little.
Trapped in the Logic of the Modern State System? European Integration in the Wake of the Financial Crisis

In the wake of the Single European Act of the mid-1980s and a series of follow-on initiatives aimed at fostering greater integration in Europe, a number of commentators began describing Europe as a truly novel political-territorial arrangement. By the middle of the 1990s, however, the adoption of a common currency came to dominate the European integration agenda. The embrace of monetary union reflected a view of European integration that was firmly embedded in the logic of the modern territorial state system. That logic led many commentators to view the success or failure of integration in terms of the degree to which powers were being transferred from state governmental and economic institutions to the central decision-making bodies of the European Union. Such an approach cast the EU as a super-state rather than as a new type of political-institutional entity. As a result, the integration project was less subversive of the state system than it might otherwise have been – bolstering the view of the Europe...
The Use of Transposable P-elements of Drosophila melanogaster for Introductory Genetics Laboratory Courses

Laboratories in introductory genetics courses often use Drosophila melanogaster as a tool for the students to understand how genes are transmitted and mapped. We demonstrate three advantages of using P-element containing inserts with the wild-type alleles of the genes to be mapped. First, inserts can be positioned at many places in the genome with relative ease; second, stocks can be chosen which have excellent viability; and third, inserts can be selected for precision in mapping with regard to marker genes. The results of a preliminary test with a beginning genetics laboratory are presented. The inserts exhibit excellent Mendelian ratios in F2 and backcross progeny and were reproducibly mapped by different student groups.
Multiple pulmonary nodules in an elderly woman.

72-year-old woman presented to the outpatient department with a 2-month history of a nonproductive cough and a 5-lb weight loss. She was a lifelong nonsmoker. Her physical examination was unremarkable. Chest radiography revealed multiple bilateral ill-defined nodules with multifocal right lung alveolar infiltrates (Fig. 1). A chest computed tomography scan after the administration of intravenous contrast showed multiple noncalcified nodules of varying size throughout both lungs, as well as alveolar infiltrates scattered throughout the right lung (Fig. 2A–C). Bronchoscopic lung biopsy samples of the right lower and right upper lobes showed adenocarcinoma with bronchioloalveolar features. Bronchioloalveolar carcinoma (BAC) is a subset of pulmonary adenocarcinoma with several unique features. It accounts for 4% of all non-small cell lung cancer, although its incidence is rising. 1 In sharp contrast to other forms of non-small cell lung cancer, women make up slightly more than half of BAC cases 1 and lifelong nonsmokers represent as many as one third of patients. 2,3 Not uncommonly, asymptomatic patients are discovered on routine chest radiography. The radiographic presentation of BAC fits one of three patterns: consolidation of one or more segments or lobes (37%–55% of the time); a solitary pulmonary nodule or mass (38% of the time), or multiple pulmonary nodules (7%–25% of the time). 2,4 Our patient’s radiographic evaluation demon
RELIGION IN AN AGE OF SCIENCE; METAPHYSICS IN AN ERA OF HISTORY

. Ian Barbour's Religion in an Age of Science is a welcome systematic, theoretical overview of the relations between science and religion, culminating his long career with a balanced and insightful appraisal. The hallmarks of his synthesis are critical realism, holism, and process thought. Barbour makes even more investment in process philosophy and theology than in his previous works. This invites further inquiry about the adequacy of a highly general process metaphysics in dealing with our particular, deeply historical world; also further inquiry about the adequacy of its panexperientialism and incrementalism.
COMPARISON OF ENVIRONMENTAL PARTICULATE MATTER DERIVED FROM STATIONARY SOURCES

ABSTRACT This report summarizes a variety of studies on the collection, characterization and biological activity of coal fly ash, oil fly ash, and volcanic ash. Methodologies are described for in situ and post-collection size-classification of particulate matter. The spherical morphology of coal fly ashes is contrasted with the large crystals and honeycomb-appearance of oil ash and the jagged, angular appearance of volcanic ash. Biological activity of coal fly ash is only slightly greater than that of inert particles, while oil fly ash is more cytotoxic than α-quartz, a potent macrophage toxicant. Although volcanic ash is morphologically similar to α-quartz, the ash is significantly less cytotoxic.
The trophic levels model for population growth depending on past history

A mathematical model for two trophic levels is modified by introducing time delays into differential equations. The time delays correspond to the predator population a generation earlier. Some properties of solutions of the model are presented.
Identification of novel QTLs for seedling and adult plant leaf rust resistance in a wheat doubled haploid population

Pyramiding of genes that confer partial resistance is a method for developing wheat (Triticum aestivum L.) cultivars with durable resistance to leaf rust caused by Puccinia triticina. In this research, a doubled haploid population derived from the cross between the synthetic hexaploid wheat (SHW) (×Aegilotriticum spp.) line TA4152-60 and the North Dakota breeding line ND495 was used for identifying genes conferring partial resistance to leaf rust in both the adult plant and seedling stages. Five QTLs located on chromosome arms 3AL, 3BL, 4DL, 5BL and 6BL were associated with adult plant resistance with the latter four representing novel leaf rust resistance QTLs. Resistance effects of the 4DL QTL were contributed by ND495 and the effects of the other QTLs were contributed by the SHW line. The QTL on chromosome arm 3AL had large effects and also conferred seedling resistance to leaf rust races MJBJ, TDBG and MFPS. The other major QTL, which was on chromosome arm 3BL, conferred seedling resistance to race MFPS and was involved in a significant interaction with a locus on chromosome arm 5DS. The QTLs and the associated molecular markers identified in this research can be used to develop wheat cultivars with potentially durable leaf rust resistance.
Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance.

Adipose dysfunction resulting from chronic inflammation and impaired adipogenesis has increasingly been recognized as a major contributor to obesity-mediated insulin resistance, but the molecular mechanisms that maintain healthy adipocytes and limit adipose inflammation remain unclear. Here, we used genetic and pharmacological approaches to delineate a novel role for sphingosine kinase 1 (SK1) in metabolic disorders associated with obesity. SK1 phosphorylates sphingosine to form sphingosine 1 phosphate (S1P), a bioactive sphingolipid with numerous roles in inflammation. SK1 mRNA expression was increased in adipose tissue of diet-induced obese (DIO) mice and obese type 2 diabetic humans. In DIO mice, SK1 deficiency increased markers of adipogenesis and adipose gene expression of the anti-inflammatory molecules IL-10 and adiponectin and reduced adipose tissue macrophage (ATM) recruitment and proinflammatory molecules TNFα and IL-6. These changes were associated with enhanced insulin signaling in adipose and muscle and improved systemic insulin sensitivity and glucose tolerance in SK1−/− mice. Specific pharmacological inhibition of SK1 in WT DIO mice also reduced adipocyte and ATM inflammation and improved overall glucose homeostasis. These data suggest that the SK1-S1P axis could be an attractive target for the development of treatments to ameliorate adipose inflammation and insulin resistance associated with obesity and type 2 diabetes.
The Dual Simplex Pivot and Its Uses

The simplex method pivots to preserve feasibility and seek optimality (nonpositive reduced costs in a maximization problem). By contrast, the “dual” simplex method pivots to preserve optimality and seek feasibility.
On event-triggered and self-triggered control over sensor/actuator networks

Event-triggered and self-triggered control have been recently proposed as an alternative to the more traditional periodic execution of control tasks. The possibility of reducing the number of executions while guaranteeing desired levels of performance makes event-triggered and self-triggered control very appealing in the context of sensor/actuator networks. In this setting, reducing the number of times that a feedback control law is executed implies a reduction in transmissions and thus a reduction in energy expenditures. In this paper we introduce two novel distributed implementations of event-triggered and self-triggered policies over sensor/actuator networks and discuss their performance in terms of energy expenditure.
Prevalence and risk factors for cerebrovascular disease in community-dwelling Latinos

Objectives Surveys on stroke prevalence may provide valuable information for planning of healthcare services. Few such studies have been conducted in Latinos and none have been performed in Los Angeles, a County that contains the largest population of Latinos in the United States. We sought to assess the prevalence of self-reported stroke in a population-based sample of community-dwelling Latinos in Los Angeles.
Effects of stress on the reproductive system of male rats and mice.

Male rats were immobilized for 2 hr/day, 5 days a week, for varying periods of time (7–31 days) to assess the effects of stress on the reproductive system. Mice were immobilized for 25–38 days. The effectiveness of the stress was demonstrated by assessing the adrenal and body weight. Adrenal weights were significantly increased (p<.05—t-test) compared to controls. Body weights were decreased compared to controls. No consistent change was noticed in the testicular weight and progressive motility of the spermatozoa drawn from the cauda epididymis and vas deferens. There were no deleterious effects of immobilization stress on the morphology of the differentiating germ cells, peritubular wall, and the interstitial tissues of the testis.