cssi/SciSciGPT-SciSciNet huggingface dataset:
Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p.

We have taken a combined genetic and biochemical approach to identify major constituents of the yeast nuclear pore complex (NPC). A synthetic lethal screen was used to identify proteins which interact genetically with the major pore-membrane protein Pom152p. In parallel, polypeptides present in similar amounts to Pom152p in a highly enriched preparation of yeast NPCs have been characterized by direct microsequencing. These approaches have led to the identification of two novel and major nucleoporins, Nup170p and Nup157p. Both Nup170p and Nup157p are similar to each other and to an abundant mammalian nucleoporin, Nup155p (Radu, A., G. Blobel, and R. W. Wozniak. 1993. J. Cell Biol. 121: 1-9) and interestingly, nup170 mutants can be complemented with mammalian NUP155. In addition, the synthetic lethal screen identified genetic interactions between Pom152p and two other major nucleoporins, Nup188p (Nehrbass, U., S. Maguire, M. Rout, G. Blobel, and R. W. Wozniak, manuscript submitted for publication), and Nic96p (Grandi, P., V. Doye, and E. C. Hurt. 1993. EMBO J. 12: 3061-71). We have determined that together, Nup170p, Nup157p, Pom152p, Nup188p, and Nic96p comprise greater than one-fifth of the mass of the isolated yeast NPC. Examination of the genetic interactions between these proteins indicate that while deletion of either POM152, NUP170, or NUP188 alone is not lethal, pairwise combinations are. Deletion of NUP157 is also not lethal. However, nup157 null mutants, while lethal in combination with nup170 and nup188 null alleles, are not synthetically lethal with pom152 null alleles. We suggest that Nup170p and Nup157p may be part of a morphologically symmetrical but functionally distinct substructure of the yeast NPC, e.g., the nucleoplasmic and cytoplasmic rings. Finally, we observed morphological abnormalities in the nuclear envelope as a function of alterations in the expression levels of NUP170 suggesting a specific stoichiometric relationship between NPC components is required for the maintenance of normal nuclear structure.
SOUL WARS: NEW BATTLES, NEW NORMS

Abstract One of the most difficult concepts pertaining to religious freedom is proselytism. Because globalization causes more interaction between religious groups, religious beliefs must now compete in the open marketplace of ideas. Increased religious competition often causes resentment and ecumenism gives way to religious balkanization and conflict. The state struggles to balance one community's right to exercise and expand its faith against another's right to be left alone to its own traditions. While inter-religious dialogue is the often-cited remedy, it must be paired with guidelines of prudence and restraint on the part of the proselytizer.
A review of the child development associate credential: Corrections and comments

The Child Development Associate Project is of sufficient magnitude and importance to warrant and benefit from a fair and open public examination. However, Berk and Berson's analysis is in need of factual correction and represents a biased view of the program. This paper seeks to set straight the facts while indicating the areas where additional research and discussion are warranted.
American passage: Towards a new economy and a new politics

Abstract America's present system of political economy is failing across a broad front — economic, social, political, and environmental. The prioritization of economic growth and economic values is at the root of the systemic failures and resulting crises that America is now experiencing. But an expanding body of evidence is now telling us to think again. Before it is too late, America should begin to move to a post-growth society where working life, the natural environment, our communities, and the public sector are no longer sacrificed for the sake of mere GDP growth, and where the illusory promises of continuous growth no longer provide an excuse for neglecting to deal generously with compelling social needs. Of particular importance for the new economy are government policies that will temper growth while simultaneously improving social and environmental well-being, policies such as shorter work weeks and longer vacations, with more time for children and families, greater labor protections, job security, and benefits, including generous parental leaves, guarantees to part-time workers, restrictions on advertising, a new design for the twenty-first century corporation, incentives for local production and consumption, rigorous environmental, health, and consumer protection, greater economic and social equality, heavy spending on public services and initiatives to address population growth at home and abroad. The best hope for a new political dynamic is a fusion of those concerned about environment, social justice, and political democracy into one progressive force. A unified agenda would embrace a profound commitment to social justice and environmental protection, a sustained challenge to consumerism and commercialism and the lifestyles they offer, a healthy skepticism of growth-mania and a new look at what society should be striving to grow, a challenge to corporate dominance and a redefinition of the corporation and its goals, and a commitment to an array of major pro-democracy reforms.
Linguistic development of children with phenylketonuria and normal intelligence

Hsia et al, ~ Berry et al, 7 and Holtzman et al 8 have reported similar data, al though we were unable to find comparable cord blood values. Subsequently, Cunningham ~ has analyzed their results and added data from 13 infants seen in the California program who had at least two blood phenylalanine values obtained at 96 hours of age or younger. He was the first to suggest that the single most important reason for "missed" cases was probably laboratory error rather than lack of protein feeding or testing the infant too early in life. Subsequently, Guthrie and Warner 9 presented data on 13 infants, collected in a similar manner as ours, which confirm the rapid rise in blood phenylalanine concentration seen in our patients. Their data were based upon the inhibition assay, and they concluded that "missed" cases are probably the result of laboratory error. Hol tzman et al 8 suggest that the "error rate" in newborn screening thrughout the United States is about 8%. On the other hand, Sepe et al TM have shown that in a state with a centralized screening program and high quality control, "missed cases" are practically nonexistent. These data argue strongly for regionalization and centralization of newborn testing for PKU.
PtdIns(4,5)P2 turnover is required for multiple stages during clathrin- and actin-dependent endocytic internalization.

The lipid phosphatidylinositol-4,5-bisphosphate (PtdIns[4,5]P2) appears to play an important role in endocytosis. However, the timing of its formation and turnover, and its specific functions at different stages during endocytic internalization, have not been established. In this study, Sla2 ANTH-GFP and Sjl2-3GFP were expressed as functional fusion proteins at endogenous levels to quantitatively explore PtdIns(4,5)P2 dynamics during endocytosis in yeast. Our results indicate that PtdIns(4,5)P2 levels increase and decline in conjunction with coat and actin assembly and disassembly, respectively. Live-cell image analysis of endocytic protein dynamics in an sjl1Δ sjl2Δ mutant, which has elevated PtdIns(4,5)P2 levels, revealed that the endocytic machinery is still able to assemble and disassemble dynamically, albeit nonproductively. The defects in the dynamic behavior of the various endocytic proteins in this double mutant suggest that PtdIns(4,5)P2 turnover is required for multiple stages during endocytic vesicle formation. Furthermore, our results indicate that PtdIns(4,5)P2 turnover may act in coordination with the Ark1/Prk1 protein kinases in stimulating disassembly of the endocytic machinery.
Radiculopathy in the setting of lumbar nerve root compression due to an extradural intraforaminal lipoma: a report of 3 cases.

A true adult spinal lipoma is an exceedingly rare cause of lumbar compression neuropathy. Only 5 cases of true extradural intraforaminal lipomas have been documented in the medical literature. The diagnostic criteria and treatment guidelines for this specific lipoma have yet to be established. This report features 3 histologically confirmed cases of extradural intraforaminal spinal lipomas that recently presented to the authors’ practice. In addition, the literature was surveyed to include the 5 previously reported cases of true adult extradural intraforaminal spinal lipomas. The consistency in presentation, response to surgical intervention, and postoperative recovery in these 8 cases supports surgical intervention at the time of diagnosis. The authors’ findings support elevated clinical suspicion, efficient diagnosis based on MRI, and early surgical intervention for this rare pathological entity. All cases presented in this report were symptomatic and occurred in the absence of other significant patholo...
Testicular cancer: Underestimating radiotherapy toxicity for stage I seminoma.

A recent survey of radiation oncologists has evaluated barriers to surveillance rather than adjuvant therapy for postorchiectomy management of stage I seminoma. The findings suggest that providers are underestimating the late toxicity of radiation therapy in these patients.
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes

Abstract We describe the generation of mammalian cell lines carrying amber suppressor genes. Nonsense mutants in the herpes simplex virus thymidine kinase (HSV tk ) gene, the Escherichia coli xanthine-guanine phosphoribosyl transferase (Eco- gpt ) gene and the aminoglycoside 3′ phosphotransferase gene of the Tn5 transposon ( NPT-II ) were isolated and characterized. Each gene was engineered with the appropriate control signals to allow expression in both E. coli and mammalian cells. Expression in E. coli made possible the use of well developed bacterial and phage genetic manipulations to isolate and characterize the nonsense mutants. Once characterized, the nonsense mutants were transferred into mammalian cells by microinjection and used, in turn, to select for amber suppressor genes. Xenopus laevis amber suppressor genes, prepared by site-specific mutagenesis of a normal X. laevis tRNA gene, were microinjected into the above cell lines and selected for the expression of one or more of the amber mutant gene products. The resulting cell lines, containing functional amber suppressor genes, are stable and exhibit normal growth rates.
Tactics-based remote execution for mobile computing

Remote execution can transform the puniest mobile device into a computing giant able to run resource-intensive applications such as natural language translation, speech recognition, face recognition, and augmented reality. However, easily partitioning these applications for remote execution while retaining application-specific information has proven to be a difficult challenge. In this paper, we show that automated dynamic repartitioning of mobile applications can be reconciled with the need to exploit application-specific knowledge. We show that the useful knowledge about an application relevant to remote execution can be captured in a compact declarative form called tactics. Tactics capture the full range of meaningful partitions of an application and are very small relative to code size. We present the design of a tactics-based remote execution system, Chroma, that performs comparably to a runtime system that makes perfect partitioning decisions. Furthermore, we show that Chroma can automatically use extra resources in an over-provisioned environment to improve application performance.
Selection rule violations in multiple quantum NMR spectroscopy

Abstract Violations of coherence transfer selection rules in multiple quantum NMR spectra of isotropic solutions are reported. In some cases these violations can be accounted for by strong coupling effects, as demonstrated via computer simulations. In many cases, however, the “forbidden” peaks likely arise due to differential relaxation rates of degenerate single quantum transitions of magnetically equivalent nuclei.
X-ray emission in the &#x201C;water-window&#x201D; from laser-produced boron-nitride plasma

Soft x-rays in the water-window (λ=2.3-4.4nm) are an attractive source for cellular microscopy due to high contrast between water and carbon rich cellular structures. Water-window microscopy allows for sub-102 nm resolution without the lengthy preparation techniques needed for transmission electron microscopy. Currently synchrotron radiation is the most common source of soft x-rays for cellular microscopy,1 but synchrotron facilities are extremely large and access is limited. In order for water-window microscopy to become a widely spread and commonly used technique, compact laboratory based systems must be developed. A laser-produced plasma (LPP) x-ray source offers the advantages of being compact with high brightness, making it popular for developing compact water-window microscopes.2
TU‐E‐350‐01: New Member Symposium/Meet the Experts

The New Members Symposium will provide an introduction to the AAPM, our current officers, council chairs and operations. AAPM leaders will remain at the symposium to continue informal discussions following the brief opening presentations. The New Members Symposium is followed directly by the Meet the Experts sessions in the same room. Bill Hendee, Gary Barnes, Dan Low and Jim Hevezi, all individuals with many years of experience will address current issues and lead discussions on many medical physics aspects of Imaging Research, Imaging Clinical, Therapy Research and Therapy clinical. Educational Objectives: 1. To introduce new members to the AAPM leadership and operations. 2. To provide discussions with experts in medical physics
Induced lexico-syntactic patterns improve information extraction from online medical forums.

Objective To reliably extract two entity types, symptoms and conditions (SCs), and drugs and treatments (DTs), from patient-authored text (PAT) by learning lexico-syntactic patterns from data annotated with seed dictionaries. Background and significance Despite the increasing quantity of PAT (eg, online discussion threads), tools for identifying medical entities in PAT are limited. When applied to PAT, existing tools either fail to identify specific entity types or perform poorly. Identification of SC and DT terms in PAT would enable exploration of efficacy and side effects for not only pharmaceutical drugs, but also for home remedies and components of daily care. Materials and methods We use SC and DT term dictionaries compiled from online sources to label several discussion forums from MedHelp (http://www.medhelp. org). We then iteratively induce lexico-syntactic patterns corresponding strongly to each entity type to extract new SC and DT terms. Results Our system is able to extract symptom descriptions and treatments absent from our original dictionaries, such as ‘LADA’, ‘stabbing pain’ ,a nd ‘cinnamon pills’. Our system extracts DT terms with 58– 70% F1 score and SC terms with 66–76% F1 score on two forums from MedHelp. We show improvements over MetaMap, OBA, a conditional random field-based classifier, and a previous pattern learning approach. Conclusions Our entity extractor based on lexicosyntactic patterns is a successful and preferable technique for identifying specific entity types in PAT. To the best of our knowledge, this is the first paper to extract SC and DT entities from PAT. We exhibit learning of informal terms often used in PAT but missing from typical dictionaries.
Evaluating pressure ulcer occurrence in long-term care: Pitfalls in interpreting administrative data

Administrative databases for long-term care frequently collect information on fixed dates of the calendar year, rather than for entire episodes of care. Patients discharged or dying prior to an evaluation date are lost to follow-up. We used one such database, the VA Patient Assessment File, to examine pressure ulcer occurrence in long-term care. Clinical studies have established that most pressure ulcers develop during the first several weeks following admission. In these data, however, pressure ulcer development was less common in patients assessed within 2 months following admission, as compared to those examined at 3 to 6 months. This finding appears to be related to the selective discharge of patients, which makes these patient populations noncomparable. These results highlight that care must be exercised when interpreting results obtained from such administrative data.
Feature selection based on mutual information for human activity recognition

In this work, we consider a classification problem of 14 physical activities using a body sensor network (BSN) consisting of 14 tri-axial accelerometers. We use a tree-based classifier, and develop a feature selection algorithm based on mutual information to find the relevant features at every internal node of the tree. We evaluate our algorithm on 31 features per accelerometer (total of 434), and we present the results on 8 subjects with a 96% average accuracy.
A transformation approach to stochastic model reduction

A new and direct approach to stochastic model reduction is developed. The order reduction algorithm is obtained by establishing an equivalence between canonical correlation analysis and solutions to algebraic Riccati equations. Also the concept of balanced stochastic realization (BSR) plays a fundamental role. Asymptotic stability of the reduced-order realization is established, and spectral domain interpretations for the BSR are given.
Multiscale approximation methods (MAME) to locate embedded consecutive subsequences: its applications in statistical data mining and spatial statistics

In statistical data mining and spatial statistics, many problems (such as detection and clustering) can be formulated as optimization problems whose objective functions are functions of consecutive subsequences. Some examples are (1) searching for a high activity region in a Bernoulli sequence, (2) estimating an underlying boxcar function in a time series, and (3) locating a high concentration area in a point process. A comprehensive search algorithm always ends up with a high order of computational complexity. For example, if a length-n sequence is considered, the total number of all possible consecutive subsequences is (n+1/2) ≈ n2/2. A comprehensive search algorithm requires at least O(n2) numerical operations.We present a multiscale-approximation-based approach. It is shown that most of the time, this method finds the exact same solution as a comprehensive search algorithm does. The derived multiscale approximation methods (MAMEs) have low complexity: for a length-n sequence, the computational complexity of an MAME can be as low as O(n). Numerical simulations verify these improvements.The MAME approach is particularly suitable for problems having large size data. One known drawback is that this method does not guarantee the exact optimal solution in every single run. However, simulations show that as long as the underlying subjects possess statistical significance, a MAME finds the optimal solution with probability almost equal to one.
K-Subspace Clustering

The widely used K-means clustering deals with ball-shaped (spherical Gaussian) clusters. In this paper, we extend the K-means clustering to accommodate extended clusters in subspaces, such as line-shaped clusters, plane-shaped clusters, and ball-shaped clusters. The algorithm retains much of the K-means clustering flavors: easy to implement and fast to converge. A model selection procedure is incorporated to determine the cluster shape. As a result, our algorithm can recognize a wide range of subspace clusters studied in various literatures, and also the global ball-shaped clusters (living in all dimensions). We carry extensive experiments on both synthetic and real-world datasets, and the results demonstrate the effectiveness of our algorithm.
The Puzzle of African Party Systems

Two puzzling features characterize African party systems: low fragmentation and high volatility. We present systematic data describing these features and provide a theoretically grounded explanation of them. The explanation emphasizes the role of strategic choice structured by the institutional legacies of authoritarian regimes in the formation and development of political parties. Political restrictions under authoritarian regimes produced severe information deficit concerning electoral mobilization, strategic coordination and the collective action problems that typically attend party formation and coalition-building. Under these constraints, political actors in Africa’s emerging democracies established political parties to preserve their fragmented power bases and relied on presidential elections and ethno-political cleavages as alternative sources of strategic coordination over votes and seats and electoral coalition-building. The result is the entry of large numbers of short-lived political parties, p...
Nature of PO bonds in phosphates.

Making use of a combination of ab initio calculated geometries, orbital energies, and orbital spatial distributions as well as experimental information about bond lengths, bond energies, vibrationa...
Integrating positive psychology into schools: Implications for practice

Traditional approaches for working with children and families in the schools focus on problems and disturbance. The concept of positive psychology as a way to change this focus is offered through exploration of its integration within school psychology. Specifically, the application of positive psychology can form the basis of preventive practices within the school setting. Examples of this application are provided within common roles of the school psychologist (consultation, direct work, educational assessment and planning). © 2004 Wiley Periodicals, Inc. Psychol Schs 41: 163–172, 2004.
Two interesting cases of fracture of sternum

Abstract Two cases are reported of complete fracture of the sternum with moderate displacement of the fragments in which a good functional union was obtained without manipulation or immobilization.
An effective technique for enhancing an intrauterine catheter fetal electrocardiogram

Physicians can obtain fetal heart rate, electrophysiological information, and uterine contraction activity for determining fetal status from an intrauterine catheters electrocardiogram with the maternal electrocardiogram canceled. In addition, the intrauterine catheter would allow physicians to acquire fetal status with one noninvasive to the fetus biosensor as compared to invasive to the fetus scalp electrode and intrauterine pressure catheter used currently. A real-time maternal electrocardiogram cancellation technique of the intrauterine catheters electrocardiogram will be discussed along with an analysis for the methods effectiveness with synthesized and clinical data. The positive results from an original detailed subjective and objective analysis of synthesized and clinical data clearly indicate that the maternal electrocardiogram cancellation method was found to be effective. The resulting intrauterine catheters electrocardiogram from effectively canceling the maternal electrocardiogram could be used for determining fetal heart rate, fetal electrocardiogram electrophysiological information, and uterine contraction activity.
Analysis and control of timing jitter in digital logic arising from noise voltage sources

Timing jitter is an important factor in limiting throughput in high-performance digital circuits, e.g. those using techniques such as wave pipelining. Many of the sources of timing jitter, such as physical noise, coupling noise, and delta-I noise, are best modeled with random shifts in signal voltages. A new analysis technique for translating such noise into timing jitter characteristics is presented. The circuit is linearized about its nominal behavior and the resulting time-varying system is discretized so that the mapping from voltage noise to timing jitter can be easily calculated and characterized. In addition, the use of differential circuit techniques to improve noise immunity is discussed. >
Controlling the hydration rate of a hydrophilic matrix in the core of an intravaginal ring determines antiretroviral release

Intravaginal ring technology is generally limited to releasing low molecular weight species that can diffuse through the ring elastomer. To increase the diversity of drugs that can be delivered from intravaginal rings, we designed an IVR that contains a drug matrix encapsulated in the core of the IVR whereby the mechanism of drug release is uncoupled from the interaction of the drug with the ring elastomer. We call the device a flux controlled pump, and it is comprised of compressed pellets of a mixture of drug and hydroxypropyl cellulose within the hollow core of the ring. The pump orifice size and chemistry of the polymer pellets control the rate of hydration and diffusion of the drug-containing hydroxypropyl cellulose gel from the device. A mechanistic model describing the hydration and diffusion of the hydroxypropyl cellulose matrix is presented. Good agreement between the quantitative model predictions and the experimental studies of drug release was obtained. We achieved controlled release rates of multiple antiretrovirals ranging from μg/d to mg/d by altering the orifice design, drug loading, and mass of pellets loaded in the device. This device could provide an adaptable platform for the vaginal drug delivery of many molecules.
Heterogenity of γ-Globulins

Publisher Summary This chapter gives a detailed physicochemical and immunologic characterization of the four classes of globulins in normal and neoplastic plasma cells. Unique characteristics of the γ-globulins are their antibody activity and an extensive heterogeneity not seen in other serum proteins. Heterogeneity is characteristic of each class of γ-globulins with respect to electrophoretic mobility, antibody activity, hexose content, antigenic determinants, and genetic properties. The serum γ -globulins in many species are now known to include three major groups of proteins (γ, β 2A, γ 1M ). A fourth group, the γ-microglobulins may be formed in normal, as well as in malignant plasmacytes and related cells. A dual relationship exists among these groups of proteins. Studies at the submolecular level of the interrelationships among different γ-globulin groups, among different γ-globulin molecules, and among different γ-globulin functions and a better understanding of the physicochemical and immunological heterogeneity of the γ-globulins is beginning to develop. This rapidly moving area of investigation, taking advantage of developments in other fields, is, in turn, contributing to advancement in many areas of immunology and other biological science.
Using Permanent and Temporary Polyimide Adhesives in 3D-TSV Processing To Avoid Thin Wafer Handling

3D chip integration processes use thinned silicon wafers in conjunction with through silicon vias. Polyimide adhesives are evaluated for use as temporary and permanent adhesives to enable handling of thinned wafers and subsequent bonding into 3D stacks. These adhesives are found to have a combination of thermal and mechanical properties and processing capabilities required for 3D chip integration applications.
Coping Capacity among Women with Abusive Partners

Coping capacity, although increasingly implicated as a mediating force in how individuals respond to personal threat, is an underrecognized factor in work with women of abusive partners. To explore the utility of coping capacity as a multivariable set to guide intervention with women of abusive partners, findings are reported comparing four groups of women: those whose partners do not engage in abuse, are abusive toward them, are sex offenders of children for whom the woman is a parent, or are offenders of children for whom the woman is not a parent. Three variable sets were included: vulnerability factors that may negatively influence appraisals of threat and ability to cope with abuse; coping responses that include cognitive, emotional, and behavioral reactions to the abuse; and coping resources expected to mediate effects of vulnerability factors and to influence the mobilization (of lack thereof) of coping responses. There were significant differences in coping capacity profiles across the four groups. These appeared to be a continuum of coping capacity, with women who were most directly threatened showing the lowest and women who were least directly threatened showing the highest levels of coping capacity. In order from the lowest to the highest levels of coping capacity were (1) battered women, (2) women whose partners are offenders against their children, (3) women whose partners are offenders against children of whom they are not the parent, and (4) control group women. The paper ends with a conceptual interpretation of the mediating functions of coping resources and implications for intervention and further study.
Smartphones: Everyone Can Do Anything

The smartphone is, many suggest, a revolutionary device that has changed the world—especially the Apple iPhone, which is the most important smartphone. There are, it turns out, more than 2500 different models of smartphones, 2 millions apps that can be used on them, and almost 7 billion smartphones in use. A new development in smartphone design, the phablet, which is a large smartphone that is also around the same size as a small tablet, is discussed. Then the idea of psychoanalyst Erik Erikson are used to help explain why smartphones play such an important role in the lives of teenagers. This is followed by a discussion of some of the negative effects of smartphone use and the desire, many smartphone users have, to wait for “the next big thing” in smartphones before upgrading to new smartphones.
A Decade of Love and Hate Trajectories of Intergenerational Ambivalence Experienced by Two Cohorts of Older Parents and Adult Children

The intergenerational ambivalence paradigm is a critical lens for understanding the complexities of aging families, and researchers have begun to explore the potential changes and implications of ambivalence over the life course. This study is one of few to examine trajectories of ambivalence over 13 years and is the first to include two birth cohorts of reciprocal parent–child dyads. This research uses five waves of the Longitudinal Study of Generations to assess changes in ambivalence and reciprocal influences among 903 parent–child dyads using latent growth models. Primary findings show an overall decline in ambivalence over time with different patterns by generation, cohort/life stage, and gender. Children experienced greater levels of ambivalence than parents. There is a reciprocal influence of ambivalence in parent–child dyads; parents and children have similar trajectories of ambivalence and the older generation of parents’ ambivalence exerted influence on the change in their children’s ambivalence...
Proteolytic enzyme inhibitors of human serum in health and disease.

SummaryMethods are described for the determination of chymotrypsin and rennin inhibitors in serum. The many physiological and pathological conditions which influence their concentration are discussed.
COFFDROP: A Coarse-Grained Nonbonded Force Field for Proteins Derived from All-Atom Explicit-Solvent Molecular Dynamics Simulations of Amino Acids.

We describe the derivation of a set of bonded and nonbonded coarse-grained (CG) potential functions for use in implicit-solvent Brownian dynamics (BD) simulations of proteins derived from all-atom explicit-solvent molecular dynamics (MD) simulations of amino acids. Bonded potential functions were derived from 1 μs MD simulations of each of the 20 canonical amino acids, with histidine modeled in both its protonated and neutral forms; nonbonded potential functions were derived from 1 μs MD simulations of every possible pairing of the amino acids (231 different systems). The angle and dihedral probability distributions and radial distribution functions sampled during MD were used to optimize a set of CG potential functions through use of the iterative Boltzmann inversion (IBI) method. The optimized set of potential functions—which we term COFFDROP (COarse-grained Force Field for Dynamic Representation Of Proteins)—quantitatively reproduced all of the “target” MD distributions. In a first test of the force fi...
Dating preferences among self-identified gay men of Asian descent in the United States.

Author(s): Nehl, EJ; Talley, CL; Yu, F; Nakayama, KK; Lin, L; Wong, FY; Ong, PM; Takahashi, LM; Ross, MW | Abstract: Little is known about the dating preferences of Asian American gay men. To conceptualize the dating preferences among these men, the impact domains model (IDM) was used to investigate if nativity and/or acculturation might explain dating preferences. Previous studies have pointed out the problematic nature of a racist cultural stereotype that Asian American gay men prefer white partners (Choi, Yep, a Kumekawa, 1998; Han, 2008). The current findings do not support that Asian American gay men prefer white partners. In our sample, 17.1% preferred dating white men and over 20% preferred Asian men. Over 60% had no clear racial/ethnic dating preference. Multivariate analyses indicated that those reporting higher ethnic acculturation (p l.001) and were U.S.-born (p l.01) were more likely to prefer dating Asian men. In contrast, those younger (p l.001) and living on the East Coast (p l.01) were more likely to prefer dating white men. Limitations of the study include a self-report cross-sectional design with purposive recruitment to study HIV/STIs and sexual health rather than dating preferences. Additionally, the data set included only a coastal classification (East vs. West Coast) and an acculturation scale which included cultural identity, language, and competence. The complex effect of nativity and acculturation on dating preference warrants further investigation. The IDM may be useful to guide future studies of partner preference among Asian MSM. Researchers in future studies should pay attention to identifying the key behavioral, social, and affective beliefs that underlie partner preference and examine actual dating practices.
Fluorescence Microscopic Examination of Basidiosporogenesis in Boletus rubinellus and Coprinus cinereus

Sterigma and basidiospore development in Coprinus cinereus and Boletus rubinellus have been examined using an optical brightener and fluorescence microscopy. Development of the ellipsoid basidiospores of C. cinereus was associated with a characteristic series of fluorescence patterns: general, asymmetric, apical and finally subapical fluorescence. In the elongate spores of B. rubinellus, after the initial asymmetric growth phase, fluorescence was consistently apical until the spore matured. Stage-specific fluorescence patterns were correlated with the changes in spore shape. Their significance is discussed.
Research for Energy-saving Technologies of Laboratory Animals Building Facilities

Design of experimental animal facilities of energy-efficient building is the key factors which hinders the normal operation of facilities for the establishment and management.Good energy-saving measures including optimization of barrier systems and the layout of IVC cages,which will help to ensure that air quality of the experimental zone,save investment and improve the comprehensive utilization rate of facilities for 3 to 5 times.Using of Variable Air Volume Control Systems,can greatly reduce the thermal energy consumption of fresh air and air-conditioning load reduced by about 10%～50% volume of fresh air power.The use of advanced smart power-saving central air conditioning system(referred to as GL-CAC),can be achieved the target for central air-conditioning Auxiliary power-saving 30%～60%,host power-saving 5% to 20%.Optimizing the health hot water and steam sterilization equipment which will help to save project investment and operating costs of 50%.The scientific management of implementation of the infrastructure system will help to save the administrative costs of human resources annual operation.
Site Test Method of Error for 1000kV Capacitor Voltage Transformer

1000 kV capacitor voltage transformer (CVT)is the new equipment in UHV AC piolt project of china,which has no precedent to go by in 1000 kV CVT errors field test. To ensure implementing the field test of 1000 kV CVT successfully,field test methods about 1000 kV CVT are studied in this paper. Based on analyzing the structural characteristic and the concrete parameters of CVT in the piolt project,three methods including difference method,voltage coefficient method are presented. By comparative the advantage and disadvantage of the three test methods,a conclusion is get that using the 1000 kV standard electromagnetic voltage transformer as the test standard and application difference method to calibrate the errors of CVT is more suitable in the filed test. According to the need of the field test,1600 kV standard capacitor,1000 kV quantity transfer and standard electromagnetic voltage transformer which used in field test are developed. In the end,this paper also analyzes the source of the uncertainty may exist in the measurement,which make the measurement deviation on one-third of permissible error.All these provide reliable guarantee to finish the field commissioning test successfully in the UHV AC project.
Association between presence of pneumonia and pressure ulcer formation following traumatic spinal cord injury.

Objective: To determine if the presence of pneumonia and pressure ulcers are associated in individuals with an acute spinal cord injury during acute care and rehabilitation hospitalizations.Design: Retrospective, secondary analyses of data obtained from the Spinal Cord Injury Model Systems enrolled from 1993 until 2006Setting: Acute care hospitalization and inpatient rehabilitation facilitiesParticipants: A cohort of individuals hospitalized in acute care (n = 3,098) and inpatient rehabilitation (n = 1,768) was included in the analysis. Frequencies of pressure ulcer formation and episodes of pneumonia were noted in both settings.Interventions: Not applicable.Outcome Measures: Pressure ulcer formation and diagnosis of pneumoniaResults: The development of pressure ulcers, including stage I, was 20.3% acute care and 21.1% during in inpatient rehabilitation. Multivariate logistic regression analyses revealed a significant association of pneumonia with occurrence of pressure ulcers (P ≤ 0.001, OR = 2.3 and 2.2...
Assessing Jitter in Sensor Time Series from Android Mobile Devices

This paper is motivated by work on a real-time Android navigation system using accelerometer, gyroscope, and camera data. We observed that our attempts at combining data from these different sensors yielded time series with jitter, i.e., inaccurate timestamps, that negatively affected program correctness and reliability. Thus, the aim of this paper is to help Android developers anticipate, assess, and understand problems with data quality in sensor-dependent applications. Our analysis focuses on jitter in timestamps obtained from Android's SensorManager and CameraManager services. We demonstrate the presence and severity of jitter obtained through these services and explain the characteristics of Android that originate jitter, resulting in a taxonomy of the various sources of jitter. Finally, we discuss the results of a quantitative analysis of jitter performed on three Android mobile devices (HTC One M8, Google Nexus 5, and Asus Zenfone 2) and provide recommendations on how Android developers can design sensing applications that will behave correctly across the majority of mobile devices.
A 12-Bit 2 GS/s Dual-Rate Hybrid DAC With Pulse-Error Pre-Distortion and In-Band Noise Cancellation Achieving > 74 dBc SFDR and <−80 dBc IM3 up to 1 GHz in 65 nm CMOS

This paper presents a 12-bit 2 GS/s dual-rate hybrid DAC using bandwidth- and linearity-enhancement techniques. The proposed pulsed-error pre-distortion scheme enhances DAC linearity at both low and high signal frequencies by leveraging the fine time-and-voltage resolution from the oversampling path of the hybrid DAC structure. To further widen the DAC bandwidth, a noise-cancellation scheme is proposed to suppress the quantization noise of the delta-sigma modulator within DC to the 1 GHz band without increasing modulator complexity. The analytical derivations and numerical simulations of the proposed techniques are provided to demonstrate the technique’s effectiveness, as well as its practical design constraints. A proof-of-concept silicon prototype is implemented in 65 nm standard CMOS that achieves SFDR of 74–98 dBc over the DC-1GHz Nyquist band. In a two-tone measurement, the IM3 product is measured from 101 dBc to 80 dBc across the Nyquist band. The SFDR improvement after enabling the proposed pulsed pre-distortion scheme measures from 67.5 to 74.4dBc, while the in-band noise floor demonstrates 6 dB suppression at the Nyquist band edge after enabling the noise-cancellation scheme.
Minority Achievement Gaps in STEM: Findings of a Longitudinal Study of Project Excite.

This longitudinal study examined the outcomes of Project Excite on reducing minority students’ achievement gaps in STEM over 14 years. Project Excite was designed to provide intensive supplemental enrichment and accelerated programming for high-potential, underrepresented minority students from third through eighth grades to better prepare them for advanced math and science courses in high school. This study compared the performance of Project Excite participants with that of students from their local school districts and the state on the Illinois Standards Achievement Test, the Explore test, the Measures of Academic Progress, and on rates of placement in above-grade-level math courses in ninth grade. Project Excite participants consistently outperformed their Black, Latino, and low-income peers, and they came close to the performance levels of White, Asian, and non-low-income students. They were more likely to be placed in above-grade-level math courses than their minority peers in ninth grade.
Inducible defenses in Olympia oysters in response to an invasive predator

The prey naivete hypothesis suggests that native prey may be vulnerable to introduced predators because they have not evolved appropriate defenses. However, recent evidence suggests that native prey sometimes exhibit induced defenses to introduced predators, as a result of rapid evolution or other processes. We examined whether Olympia oysters (Ostrea lurida) display inducible defenses in the presence of an invasive predator, the Atlantic oyster drill (Urosalpinx cinerea), and whether these responses vary among oyster populations from estuaries with and without this predator. We spawned oysters from six populations distributed among three estuaries in northern California, USA, and raised their offspring through two generations under common conditions to minimize effects of environmental history. We exposed second-generation oysters to cue treatments: drills eating oysters, drills eating barnacles, or control seawater. Oysters from all populations grew smaller shells when exposed to drill cues, and grew thicker and harder shells when those drills were eating oysters. Oysters exposed to drills eating other oysters were subsequently preyed upon at a slower rate. Although all oyster populations exhibited inducible defenses, oysters from the estuary with the greatest exposure to drills grew the smallest shells suggesting that oyster populations have evolved adaptive differences in the strength of their responses to predators. Our findings add to a growing body of literature that suggests that marine prey may be less likely to exhibit naivete in the face of invasive predators than prey in communities that are more isolated from native predators, such as many freshwater and terrestrial island ecosystems.
Inoperable patients with acute type A dissection: are they candidates for endovascular repair?

OBJECTIVES The objectives are to (i) report characteristics and outcomes of patients with inoperable acute type A aortic dissection, (ii) describe proximal aortic morphology and (iii) identify potential for endovascular treatment of the entry tear. METHODS Fifty-three (7.7%) of 686 patients with acute type A dissection between 2005 and 2015 were deemed inoperable. Chart review and active follow-up were performed for clinical characteristics and outcomes. Specific attention was directed at determining the reasons for inoperability. Twenty-four patients had computed tomography scans available for 3D reconstruction and imaging analysis. Measurements included diameter and cross-sectional area at multiple levels; plus lengths along the centreline, greater and lesser curves and outer wall of dissection. The entry tear location was identified. Entry tears between the sinotubular junction and innominate artery, or distal to the left subclavian artery, were considered amenable to endovascular repair. RESULTS The reasons for inoperability were characterized as very high-risk 35 (66%) or prohibitive 18 (34%). Prohibitive risk factors included dementia, severe stroke, malperfusion and advanced malignancy. Thirty-day mortality occurred in 35 (66%). On imaging analysis, the sinotubular junction was <45 mm in 18 (75%). The false lumen was located along the greater curve in 16 (67%), lesser curve 2 (8%), anteriorly in 5 (21%) and posteriorly in 1 (4%). The entry tear was potentially amenable to coverage in 19 (79%) patients-between the sinotubular junction and innominate artery in 18 patients and distal to the left subclavian artery in 1 patient. The entry tear was in the aortic root and arch in 1 patient (4%) each and not visible in 3 patients (13%). CONCLUSIONS Only one-third of inoperable patients are prohibitive risk for any intervention. The entry tears in most patients are potentially coverable with endovascular devices. Additional imaging and engineering analysis will guide the design of disease specific devices.
The Effect of Sport Specialization on Lower Extremity Injury Rates in High School Athletes

Objectives:Sport specialization has been shown to be associated with increased risk of musculoskeletal lower extremity injuries (LEI) in adolescent athletes presenting in clinical settings. However...
Multitask LS-Svm for Predicting Bleeding and Re-operation Due to Bleeding

Individualized blood transfusion management would benefit from the ability to prospectively identify patients at risk of complications of blood transfusion, and target them for closer monitoring or intervention. This study presents a simple and efficient multi-task learning method for predicting multiple surgical outcomes based on the weighted least squares support vector machine. To accelerate the training process, the input data is mapped onto a low dimensional randomized feature space leading to a simple linear system that can be solved with any existing fast linear or gradient based methods. Results for predicting early re-operation due to bleeding for patients undergoing non-cardiac operations from an institutional transfusion datamart illustrates that the method can reduce misclassification errors by as much as 13 compared to learning independent models. To further demonstrate the general applicability of the proposed method, a series of experiments are performed on synthetic data sets for scalability and on a real public data set for accuracy and robustness.