cssi/SciSciGPT-SciSciNet huggingface dataset:
In the Company of Microbes: Ten Years of Small Things Considered

In the Company of Microbes is now available on Wiley.comMembers, use the code ASM20 at check out to receive your 20% discount. A look at the amazing, groovy world of microbes With more than 1,000 posts and 2 million views, the esteemed blog Small Things Considered has been sparking the imagination of microbiologists for an entire decade. Throughout the years, Elio Schaechter and his team of dedicated bloggers have shared exciting, unexpected, and unusual stories from the microbial world. In the Company of Microbes is a carefully selected treasure chest of wise, amusing, and even profound statements about the ubiquity and relevance of the microbial world. Schaechter, other past ASM Presidents, and distinguished microbiologists from around the globe reflect on personal, sometimes historic interactions with microbes and unexpected discoveries, each essay conveying the excitement and sense of surprise that microbiology holds for them. This is the reason that Small Things Considered is a scientific and social media phenomenon that has impacted scientists at every stage of their careers and shared the magic of microbes with world. Join Schaechter in discovering a never-ending pageant of astounding variations on the theme of microbial life. Enjoy! “ Since Elio Schaechter’s blog, Small Things Considered, first appeared 10 years ago, I have looked forward to each post. I smiled, laughed, and always learned something new about the microbial world. Elio’s style is uniquely engaging and makes microbiology come alive. This book captures all the best of Elio’s magic. It is a must-read for students of microbiology of any age.” Lynn W. Enquist, Henry L. Hillman Professor in Molecular Biology and Professor in the Princeton Neuroscience Institute, Princeton University Watch author Elio Schaechter discuss the creation process of In the Company of Microbes: Ten Years of Small Things Considered during ASM Microbe 2016. Click here to watch "ASM Press' Author Insights with Moselio Schaechter." Hardcover, 292 pages EST, full-color illustrations, index.
The Power of Abstract Images in Advertising

Marketers have discovered the power of utilizing images in advertisements as a means to convey the experience of their product offerings. Advertising images of human models engaging in the product experience have the power to create self- referent schema storylines, emit emotions, and effect attitudes and behavior intentions toward that of the product. However, little research has been done to investigate the effect of a model’s image on the ability to fully engage the participant in self- referent processing. Does an abstract image of the model allow for the participant to transport themselves into the role of the model more easily than that of an image which clearly shows the distinguishing features of the model?
New Directions in 4-Manifold Theory

This last fall, Seiberg and Witten introduced exciting new techniques to the theory of 4-manifolds. My first lecture will serve as an introduction to Donaldson theory and to the Seiberg-Witten equations. I will outline the major acheivements of both theories and highlight their differences. Many of the new results that I will speak about in Lecture 1 have already appeared in print. In my next two lectures I will discuss applications of Seiberg-Witten Theory which have not yet appeared. In Lecture 2, I will discuss the invariants of Seiberg and Witten and their use in proving the ‘Immersed Thorn Conjecture’. In Lecture 3, I will talk about the problem of realization of intersection forms and the 11/8 Conjecture (still unsolved).
Integrated coherent combining of photonic crystal Bragg lasers with triangular lattice

We demonstrate on-chip coherent combining of broad-area photonic crystal (PC) Bragg lasers with triangular lattice for high power, single wavelength operation. Compared to rectangular lattice in conventional PC Bragg lasers, the triangular lattice eliminates the interface mismatch around the coupling region and provides comparable performance.
14 – Relationship Between Humans and Their Viruses

This chapter addresses those viruses that are considered to be viruses of humans. Viruses of humans are those that induce the diseases known as acquired immunodeficiency syndrome, fever blisters, measles, mumps, polio, rubella, smallpox, T-cell leukemia, T-cell lymphoma, and type A influenza. Many of the viruses that can infect humans are not considered as virus of humans, but rather as zoonotic. Zoonotic viruses are those viruses of animals that can cross boundaries such that they occasionally infect humans. Zoonotic category includes most of the human illnesses induced either by arboviruses or by the hemorrhagic fever viruses. Humans represent dead-end hosts for zoonotic viruses. Achieving self-reproduction is the first principal goal of the virus. This chapter addresses the questions of where and how the virus begins its march through the host body, and how the virus then continues the course of this attack, leading ultimately to the concept of viral reproduction strategies at the host population level.
Sprint’s Social Media Ninja Program: A Model for Teaching Consumer Relations

This study reviews the application of a new training model, Sprint’s Social Media Ninja program, an innovative approach to using new media to initiate change. Sprint recognized change management mu...
Unified versus Divided Political Authority

Is unified or divided authority optimal for voter welfare? We study this question in a political agency model where a politician’s task-specific competences are correlated. The model highlights tra...
Applications of synergistic combination of remote sensing and in-situ measurements on urban monitoring of air quality

In this study, multiple remote sensing and in-situ measurements are combined in order to obtain a comprehensive understanding of the aerosol distribution in New York City. Measurement of the horizontal distribution of aerosols is performed using a scanning eye-safe elastic-backscatter micro-pulse lidar. Vertical distribution of aerosols is measured with a co-located ceilometer. Furthermore, our analysis also includes in-situ measurements of particulate matter and wind speed and direction. These observations combined show boundary layer dynamics as well as transport and inhomogeneous spatial distribution of aerosols, which are of importance for air quality monitoring.
Fostering Insights: A Strengths-Based Theory of Parental Transformation

Parent’s awareness that their child’s development is not proceeding as they expected can create an unanticipated transition from being a parent to becoming the parent of a child with a developmental diagnosis. While many transition theories contribute to our understanding of how parents’ experience change over time, many traditional transition models are not family-centered and do not provide a strengths-based perspective of parents’ experiences during this transition. This paper describes the process of theory derivation to develop a strengths-based theory of parental transformation (STPT). We used the theory of well-being of refugee women experiencing cultural transition to gain insights into parents’ experiences related to their child’s diagnosis. We propose that the STPT addresses a gap in the literature by situating the diagnostic process within a strengths’ based framework that aligns with contemporary perspectives regarding disability. The STPT emphasizes understanding parents’ experiences and needs in ways that promote personal growth to support the parent and child.
Faculty perceptions and participation in distance education: pick fruit from the low-hanging branches

Motivating faculty members to teach at a distance has been a challenge for most colleges and universities. What will be th impact of teaching using technology on faculty responsibility? Is teaching students through any or all distance education methods really nothing more than adapting traditional classroom approaches? What are the attitudes and barriers to using technologies often associated with distance education? In this chapter the authors present data obtained from an extensive survey of faculty opinions on teaching at a distance, as well as several case studies describing incentives and training made available for distance education. To enhance participation in distance education, faculty must have the competence, attitude that distance education is important and valuable, and infrastructure available to facilitate the additional time and effort to convert courses. Faculty training programs cannot be one-shot and should include personnel in close proximity to faculty, preferable on their own equipment. Release time is an important incentive to encourage participation.
The lysosome as a mediator of hormone action.

Publisher Summary This chapter describes that nuclear invasion by lysosomal constituents serve as an obligatory early step in the coupling of metabolic responses leading to hormone-induced growth of specific target organs. Coordinated responses to events in the life of the whole cell involve the nucleus absolutely; both under conditions of rest and during circumstances leading to hormonally induced growth and differentiation. It has been found that participation of the phagolysosomal system in rapid and specific hormonal responses leads to invasion of the nucleoplasm by lysosomal components and to dramatic alterations of the cytoplasmic and intranuclear environments. Lysosomes have been shown to coalesce with the plasma membrane, a process that is reversible on interaction with a variety of chemical substances, which are preferentially accumulated in these organelles. Lysosomes also exhibit extraordinary intracellular mobility when their redistribution toward the nucleus is triggered by a variety of changes in the cellular environment. The target-specific lysosome, on activation by tropic hormone, serves as the mobile link for information transfer between the cell surface and the nucleoplasm.
A Review of: “Kitchen Literacy: How we Lost Knowledge of where Food Comes from and why we Need to get it Back”

In Kitchen Literacy, Ann Vileisis links the history of what home cooks in the U.S. know about where food comes from to changes in their understanding of its relationship to nature. She brings to th...
Phylogenetic Regression for Binary Dependent Variables

We compare three methods for phylogenetic regression analyses designed for binary dependent variables (traits with two discrete states) both with each other and with “standard” methods that either ignore phylogenetic relationships or ignore the binary character of the dependent variable. In simulations designed to reveal statistical problems arising in different methods, PLogReg (Ives and Garland 2010) performed better than PGLMM (Ives and Helmus 2011) and MCMCglmm (Hadfield 2010) to identify phylogenetic signal in the absence of independent variables; PLogReg also outperformed a standard method for detecting phylogenetic signal in binary data, ancestral character estimation (Schluter et al. 1997; Pagel 1994). All three phylogenetic methods performed similarly for identifying relationships with a continuously valued independent variable x, with all methods having at most moderately inflated Type I error rates, and MCMCglmm having slightly greater power. In contrast, standard logistic regression that ignores phylogeny had seriously inflated Type I errors when x had phylogenetic signal. Perhaps surprisingly, phylogenetic regression that ignored the binary nature of the dependent variable, RegOU (Lavin et al. 2008), performed as well or better than the other methods, at least for larger sample sizes (≥64 species), although this approach does not result in a model that can be used to simulate data (e.g., for bootstrapping). We also apply the methods to a data set describing whether antelopes fight or flee versus hide from predators as a function of their group size (Brashares et al. 2000). We end with rough guidelines for analyzing binary dependent variables, with the main recommendation being that multiple methods and simulations should be used to give confidence in the statistical results.
Influence of 4 and 4′ Substituents on RuIII/II Bipyridyl Self-Exchange Electron Transfer Across Nanocrystalline TiO2 Surfaces

Lateral self-exchange electron transfer across oxide surfaces is important to many solar energy capture and conversion schemes. Substituent effects on lateral RuIII/II self-exchange electron transfer were studied using a series of RuII polypyridyl compounds of the type [Ru(R2bpy)2(P)]2+, where P is 2,2′-bipyridyl-4,4′-diphosphonic acid and R2bpy was a 4,4′-substituted-2,2′-bipyridine with six different R groups: −OCH3, −C(CH3)3, −CH3, −H, −Br, and −CF3. These functional groups were chosen mainly for their electron-withdrawing or -donating ability. Chronoabsorptometry was used to probe the apparent diffusion coefficient, DCA, that was proportional to the self-exchange rate constants, and these values were found to be between 2.8 × 10–11 and 7.9 × 10–9 cm2/s. The measured DCA values showed no correlation with the electron-withdrawing or -donating ability of the functional groups, but were instead correlated with the steric size of the substituents that also influenced the saturation surface coverage and thu...
The case for a market for livers

Abstract. Liver transplantation is a necessary procedure to save the lives of thousands of people suffering from a multitude of diseases. Unfortunately, there are currently 14,301 individuals in the United States in dire need of a liver currently on the wait list, with more people added each year than removed as a result of successful transplantation. This is largely due to the National Organ Transplant Act of 1984’s outlawing the compensation of donors for their organs, which, in concurrence with basic economic theory, has resulted in a vast supply shortage. This paper aims to assess the state of the organ transplantation system in the United States and make the case that compensation for organ donors will not only remedy the vast shortage, but would prove to be a more economical alternative than the status quo. Keywords. Market for livers, National organ transplant. JEL. I11, I18.
Hypervascular Metastatic Spine Tumor Angiographic Relationships with the Artery of Adamkiewicz and Other Radiculomedullary Arteries

Background Preoperative endovascular embolization of hypervascular metastatic spine tumors can reduce intraoperative blood loss. One frequent objection to embolizing these tumors is the concern for associated arteries feeding the spinal cord, such as the artery of Adamkiewicz. This study aimed to elucidate a relationship between spinal levels affected by hypervascular spine metastases and associated radiculomedullary arteries (RMAs). Methods A retrospective review of 46 patients who underwent preoperative embolization of hypervascular metastatic spine tumors was conducted. A total of 484 spinal levels were evaluated by diagnostic spinal angiography during embolization procedures. Each spinal level was categorized based on the presence or absence of tumor and RMA. Results No statistically significant associations were found. The relative risk of affected spinal levels having an associated RMA was 1.10 (95% confidence interval, 0.66–1.85). The attributable risk was 0.01 (−0.01 to 0.02). Chi-squared statistic was 0.13, with a P value of 0.7. Subgroup analysis in renal cell patients was also statistically insignificant, with a relative risk of 0.97 (95% confidence interval, 0.43–2.16). Chi-square statistic was 0.01, with a P value 0.94. A total of 32 patients (69.6%) had an RMA identified on their regional angiogram. Seventeen patients (37%) had an RMA at an embolized level. Conclusions In this study, no association was found between spinal levels affected by hypervascular metastatic spine tumors and RMAs feeding the spinal cord by diagnostic spinal angiography. This suggests that these tumors have little intrinsic affinity for spinal levels with an RMA. However, given that tumor embolization frequently requires accessing multiple levels, the risk of encountering an RMA during embolization remains significant.
IL17A Blockade Successfully Treated Psoriasiform Dermatologic Toxicity from Immunotherapy.

Dermatologic toxicities are the most common immune-related adverse events (irAE) secondary to immune checkpoint inhibitors (ICI). First-line treatment for grade 3 or 4 skin irAEs is high-dose corticosteroids, which have their own side effects. Prolonged treatment with corticosteroids may abrogate antitumor ICI activity. The cellular causes of these dermatologic toxicities, which can manifest as a variety of clinical presentations, remain unclear. Beyond steroids, recommended treatment options are limited. We report a case of psoriasiform dermatologic toxicity, induced by inhibition of PD-1 with the mAb pembrolizumab, which resolved after treatment with systemic interleukin IL17A blockade. Introduction of IL17A blockade did not alter the patient9s melanoma response to pembrolizumab. This case suggests a possible pathogenic role of Th17 cells the irAE of the skin in this metastatic melanoma patient.
Coastal Ocean Modeling & Dynamics - ESS

Abstract : The central objective of the proposed research is to explore problems in coastal ocean modeling and dynamics, including Lagrangian trajectory analysis and the various roles played in coastal ocean predictability by basic physical elements of coastal ocean circulation. The research is being conducted by a graduate student, in collaboration with the PI. The long-term goal of this research is to improve our ability to understand and predict environmental conditions in the coastal ocean.
After the Coup. The National Council for Peace and Order Era and the Future of Thailand

Reading this collection at the fifth anniversary of the 2014 military coup is an exercise in reminding oneself of the lengths the military has gone to in embedding authoritarianism in Thailand. Whi...
Philadelphia-Negative Myeloproliferative Neoplasms: Laboratory Workup in the Era of Next-Generation Sequencing

To review the impact of next-generation sequencing (NGS) on laboratory approach of myeloproliferative neoplasms (MPNs). Next-generation sequencing has provided valuable information on the mutational landscape of MPNs and has been used for various applications, including diagnosis, risk stratification, monitoring of residual disease or disease progression, and target therapy. Most commonly, targeted sequencing of a panel of genes that have been shown to be recurrently mutated in myeloid neoplasms is used. Although numerous studies have shown the benefit of using NGS in the routine clinical care of MPN patients, the complexity of NGS data and how these data may contribute to the clinical outcome have limited the development of a standard clinical guideline. We review recent literature and discuss how to interpret and use NGS data in the clinical care of MPN patients.
Ocular tissue changes associated with anterior segment opacity in lumpfish (Cyclopterus lumpus L) eye.

Lumpfish use their vision to hunt prey or, in the case of aquaculture, to see and eat pelleted diets. A common anterior ocular opacity abnormality designated in the literature as "cataract" described in both farmed and wild lumpfish has not yet been characterized in detail at the pathobiological level. We describe here lens tissue changes associated with cataract in cultured and domesticated lumpfish. Methodology included gross observations, ophthalmoscopy and histology. Young adult cultured animals approaching 400 days post-hatch presented a range of anterior segment opacities associated with lenticular abnormalities observable at a histological level. Wild aged domesticated animals also displayed cataracts characterized mainly by abnormalities of the lens observed by both ophthalmoscopy and histology. Dysplastic lesions of the lens in one aged domesticated lumpfish were accompanied with both retinal and optic nerve degeneration. These novel naturally occurring anatomical changes in lumpfish present both commonalities and unique features associated with cataract in young adult cultured animals versus aged domesticated broodstock animals.
Immigration Policy and Terrorism: An Empirical Analysis

Though populist politicians deem the terrorist threat as a reason for restrictive immigration policies, existing studies neglect to explore the systematic connection between immigration and securit...
Resident experience in brachytherapy: An analysis of Accreditation Council for Graduate Medical Education case logs for intracavitary and interstitial brachytherapy from 2007 to 2018.

Abstract Purpose We sought to characterize temporal trends of radiation oncology resident–reported case experience with intracavitary brachytherapy (ICBT) and interstitial brachytherapy (ISBT). Methods and Materials Summarized, deidentified case logs for graduating radiation oncology residents (GRORs) between 2007 and 2018 were obtained from the Accreditation Council for Graduate Medical Education national summary data report. Cases were subdivided based on the site of treatment. Analysis of variance was used to determine differences, and strength of association was evaluated using the Pearson correlation. Results The number of GRORs increased by 66% from 114 in 2007 to 189 in 2018 (p Conclusions The average number of ICBT cases per GROR has increased, although this does not differentiate between cylinder and tandem-based insertions currently. There has been a steady decline in ISBT experience. These findings may have implications for the development of Accreditation Council for Graduate Medical Education case minimums for residency programs.
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis.

Background & Aims Pancreatic ductal adenocarcinomas (PDACs) are hypovascular, resulting in the up-regulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes the survival of cells under low-oxygen conditions. We studied the roles of HIF1A in the development of pancreatic tumors in mice. Methods We performed studies with KrasLSL-G12D/+;Trp53LSL-R172H/+;Pdx1-Cre (KPC) mice, KPC mice with labeled pancreatic epithelial cells (EKPC), and EKPC mice with pancreas-specific depletion of HIF1A. Pancreatic and other tissues were collected and analyzed by histology and immunohistochemistry. Cancer cells were cultured from PDACs from mice and analyzed in cell migration and invasion assays and by immunoblots, real-time polymerase chain reaction, and liquid chromatography–mass spectrometry. We performed studies with the human pancreatic cancer cell lines PATU-8988T, BxPC-3, PANC-1, and MiaPACA-2, which have no or low metastatic activity, and PATU-8988S, AsPC-1, SUIT-2 and Capan-1, which have high metastatic activity. Expression of genes was knocked down in primary cancer cells and pancreatic cancer cell lines by using small hairpin RNAs; cells were injected intravenously into immune-competent and NOD/SCID mice, and lung metastases were quantified. We compared levels of messenger RNAs in pancreatic tumors and normal pancreas in The Cancer Genome Atlas. Results EKPC mice with pancreas-specific deletion of HIF1A developed more advanced pancreatic neoplasias and PDACs with more invasion and metastasis, and had significantly shorter survival times, than EKPC mice. Pancreatic cancer cells from these tumors had higher invasive and metastatic activity in culture than cells from tumors of EKPC mice. HIF1A-knockout pancreatic cancer cells had increased expression of protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B). There was an inverse correlation between levels of HIF1A and PPP1R1B in human PDAC tumors; higher expression of PPP1R1B correlated with shorter survival times of patients. Metastatic human pancreatic cancer cell lines had increased levels of PPP1R1B and lower levels of HIF1A compared with nonmetastatic cancer cell lines; knockdown of PPP1R1B significantly reduced the ability of pancreatic cancer cells to form lung metastases in mice. PPP1R1B promoted degradation of p53 by stabilizing phosphorylation of MDM2 at Ser166. Conclusions HIF1A can act a tumor suppressor by preventing the expression of PPP1R1B and subsequent degradation of the p53 protein in pancreatic cancer cells. Loss of HIF1A from pancreatic cancer cells increases their invasive and metastatic activity.
An Investigation of How Nitrogen Monoxide (NO) and Nitrogen Dioxide (NO2) Are Produced in Oxidations by Nitric Acid (HNO3)

In oxidations by nitric acid (HNO3), such as the dissolution of gold (Au) in aqua regia, mixtures of nitrogen monoxide (NO) and nitrogen dioxide (NO2) are produced. In this article, the exact proce...
Secondary Prophylaxis of Variceal Bleeding in Liver Cirrhosis

Variceal hemorrhage is a serious complication of cirrhosis and associated with significant morbidity and mortality. After initial treatment of an index variceal bleeding event, secondary prevention of variceal hemorrhage is of upmost importance. Numerous treatment modalities are accessible; however, knowledge of the efficacy, potential determinants, and application of each individual therapeutic option remains paramount in optimizing rebleeding rates and survival among this patient population. More specifically, this chapter summarizes the role of endoscopic interventions, pharmacotherapy, combination therapy, and transjugular intrahepatic portosystemic shunt (TIPS) placement in the management of secondary prophylaxis for variceal hemorrhage. Based upon thorough dissection of primary literature chiefly via randomized controlled trials and meta-analyses, the most robust evidence supports the utilization of combination therapy, predominantly with endoscopic variceal ligation plus nonselective beta-blocker (NSBB), for the secondary prevention of esophageal variceal bleeding. There currently is little evidence to suggest the routine addition of isosorbide mononitrate (ISMN) to NSBB or combination therapy. Yet, the recommendations surrounding ISMN will likely remain volatile given the recent debate supporting hepatic venous pressure gradient directed therapy. On the other hand, NSBB does not have a well-established role in the secondary prophylaxis of gastric variceal hemorrhage, where endoscopic interventions still provide superior efficacy. However, TIPS continues to provide superior efficacy in the reduction of rebleeding rates for both esophageal and gastric variceal hemorrhage. TIPS placement remains the preferred option when these primary therapeutic interventions fail; additionally, there is mounting evidence for early TIPS among patients with advanced cirrhosis. Overall, current evidence supports a combined therapeutic approach, principally through endoscopic interventions and pharmacotherapy; however, a comprehensive knowledge of the myriad of treatment options is essential for optimizing the management of secondary prevention of variceal bleeding.
Outcomes with Preoperative Biliary Stenting After Pancreaticoduodenectomy In the Modern Era

Previous studies have documented increased complications following pancreaticoduodenectomy in patients who undergo preoperative biliary stenting (PBS). However, in the modern era, the vast majority of patients with jaundice are stented. We hypothesized that there is no difference in short-term postoperative outcomes between PBS and no PBS in patient with obstructive jaundice undergoing pancreaticoduodenectomy. We performed an analysis using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) participant use file (2014–2017). Patients who received neoadjuvant chemotherapy and required stenting were excluded from the analysis. A propensity-matched analysis was performed to select obstructive jaundice patients who underwent PBS and those who did not with similar characteristics prior to pancreaticoduodenectomy. Short-term postoperative outcome measures included superficial surgical site infection (S-SSI), deep surgical site infection (D-SSI), hospital length of stay (LOS), postoperative pancreatic fistula (POF), hospital readmission, minor morbidity (Clavien-Dindo I–II), major morbidity (Clavien-Dindo III, IV, V), and 30-day mortality. A total of 5851 patients with obstructive jaundice underwent pancreaticoduodenectomy without neoadjuvant chemotherapy. 81.6% underwent PBS. Based on the propensity-matched analysis, 927 patients who received PBS and 927 patients who did not were selected for comparing the outcomes between the two groups. There was no significant difference in outcome measures between the two groups with respect to S-SSI (OR 1.30 , 95% CI = 0.94–1.80, p = 0.12), D-SSI (OR 1.07, 95% CI = 0.81–1.41, p = 0.62), POF (OR 1.11, 95% CI = 0.87–1.42, p = 0.40), hospital readmission (OR 0.99, 95% CI = 0.77–1.27, p = 0.94), minor morbidity (OR 0.91, 95% CI = 0.76–1.11, p = 0.36), major morbidity (OR 0.84, 95% CI = 0.67–1.06, p = 0.14), and 30-day mortality (OR 1.05, 95% CI = 0.57–1.95, p = 0.87). Patients who underwent PBS were more likely to have shorter LOS (RR 0.87, 95% CI = 0.81–0.93, p < 0.0001). Contrary to previously reported studies, there was no increased risk of short-term postoperative outcomes after pancreaticoduodenectomy between PBS and N-PBS in a propensity-matched analysis. Preoperative biliary stenting is safe and does not need to be avoided before surgical intervention in patients who present with obstructive jaundice.
THE STRUCTURE OF DARK MOLECULAR GAS IN THE GALAXY. I. A PILOT SURVEY FOR 18 cm OH EMISSION TOWARD l≈ 105°, b≈ +1°

We report the first results from a survey for 1665, 1667, and 1720 MHz OH emission over a small region of the Outer Galaxy centered at . This sparse, high-sensitivity survey ( mK rms in 0.55 km s?1 channels), was carried out as a pilot project with the Robert C. Byrd Green Bank Telescope (GBT) (FWHM ) on a 3 ? 9 grid at spacing. The pointings were chosen to correspond with those of the existing 12CO(1-0) CfA survey of the Galaxy done at a similar resolution (8.?4). With 2 hr integrations, 1667 MHz OH emission was detected with the GBT at of the 27 survey positions ( ), confirming the ubiquity of molecular gas in the ISM as traced by this spectral line. With few exceptions, the main OH lines at 1665 and 1667 MHz appear in the ratio of 5:9 characteristic of LTE at our sensitivity levels. No OH absorption features are recorded in the area of the present survey, in agreement with the low levels of continuum background emission in this direction. At each pointing the OH emission appears in several components extending over a wide range of radial velocity and coinciding with well-known features of Galactic structure such as the Local Arm and the Perseus Arm. In contrast, little CO emission is seen in the survey area; less than half of the identified OH spectral features show detectable CO counterparts at the CfA sensitivity levels, and these are generally relatively faint. There are no CO features without corresponding OH emission in our survey. With very few exceptions, peaks in the OH profiles coincide with peaks in the GBT H i spectra (obtained concurrently, FWHM 8.?9), although the converse is not true. We conclude that main-line OH emission is a promising tracer for the ?dark molecular gas? in the Galaxy discovered earlier in far-IR and gamma-ray emission, although further work is needed to establish the quantitative details of the connection. Further aspects of the OH CO relation are revealed in a scatter plot of CO versus OH line strengths. This plot suggests a rough proportionality between the bright envelope of the CO emission (when present) and level of the accompanying 1667 MHz OH emission. Finally, we note several cases of anomalous OH emission. One survey position shows several narrow OH spectral features which are not well correlated with the H i spectrum; these features have been identified with a nearby known OH?IR star. Also, nine neighboring survey positions show enhanced emission at 1720 MHz, consistent with earlier observations and with models involving extended regions of elevated particle density.
Patient's compliance is a contributor to failure of extended antithrombotic prophylaxis in colorectal surgery: prospective cohort study.

Venous thromboembolic events (VTE) continue to be a major source of morbidity following colorectal surgery. Selective extended VTE prophylaxis for high-risk patients is recommended; however, provider compliance is low. The purpose of this study is to evaluate whether the “global” extended use of enoxaparin in all colorectal patients is feasible and safe. This is a prospective study conducted at a tertiary care center. All Patients undergoing elective colorectal procedures from November 1, 2017 to October 31, 2018 were discharged on 30 days of enoxaparin. Safety of use and patient compliance were examined. Total of 270 patients received extended prophylaxis during the study period (100% of intended patients) with five VTE recorded (1.85%). There was no significant difference in rates of VTE or complications when compared to years of selective prophylaxis (1.26% for 2016, 2.32% for 2017). Only 64% of patients reported full compliance. Global use of extended enoxaparin prophylaxis is safe, but does not decrease rates of VTE when compared to selective use. Patient’s non-adherence is likely a significant contributing factor.
Parasitism and Predation on Sentinel Egg Masses of Three Stink Bug Species (Hemiptera: Pentatomidae) in Native and Exotic Ornamental Landscapes.

This study evaluated parasitism and predation on sentinel egg masses of three stink bug species, the spined soldier bug, Podisus maculiventris (Say), the brown stink bug, Euschistus servus (Say), and the invasive brown marmorated stink bug (BMSB), Halyomorpha halys (Stal), in ornamental landscapes composed of either native or exotic plants. This study also compared the species composition of parasitoids attacking two native stink bug species (P. maculiventris and E. servus) with those attacking the invasive BMSB on the same tree species in the same habitat. Overall, egg parasitism and predation were much higher on the two native stink bug species compared with BMSB, with an average parasitism rate of 20.6% for E. servus, 12.7% for P. maculiventris, and only 4.2% for H. halys and an average predation rate of 8.2% for E. servus,17.7% for P. maculiventris, and 2.3% for H. halys. Egg predation was also significantly higher on P. maculiventris than on E. servus eggs. Eight parasitoid species attacked sentinel stink bug eggs in the ornamental landscaped plots. Trissolcus euschisti (Ashmead) (Hymenoptera: Scelionidae) was the predominant parasitoid for all three stink bug species. There were no significant differences in parasitism and predation rates on any of the stink bug species between native and exotic plots. Therefore, there is no evidence that ornamental landscapes composed of native plants increased parasitism or predation rates of sentinel egg masses of two native stink bug species or the invasive BMSB, compared with those composed entirely of exotic plants.
A Simulated Reality for Patient Care: An Alternative to the Social Distancing Barriers of COVID-19

At present, the conditions brought about by the COVID-19 pandemic affect the consistency, quality, and amount of exposure prelicensing nursing students have to hands-on clinical experiences. Hospitals and other health care organizations are limiting or prohibiting student nurse clinical participation within their environments to comply with communicable disease policies and protect student and patient health. This contributes to an atmosphere in which entry-level nursing students may come into the workforce lacking a sound experiential base obtained in a clinical setting due to social distancing and other pandemic restrictions. Due to decreasing hands-on clinical experiences, it is important to fashion a new environment for nursing students to practice skills. Simulated Hospital Day (SHD) activities in a laboratory setting can contribute to meeting this need. A study was done to evaluate the effect of a SHD on the awareness and competency of pre-licensing nursing students regarding specific nursing interventions and critical thinking performed throughout the SHD. Findings showed a substantial rise in both core awareness and perceived skill competency. It is proposed that these findings may extend to SHD activities modified in response to COVID-19 guidelines. Innovative teaching strategies driven by such modifications may prove useful across educational disciplines for creating environments that promote student achievement of learning outcomes during a global pandemic.
Demographics and outcome of dogs and cats enrolled in the PetSafe program at the Purdue University College of Veterinary Medicine: 2004-2019.

Objective To determine the number and species of animals cared for by the PetSafe program at the Purdue University College of Veterinary Medicine (a community service offered to meet the short-term housing needs of pets, especially pets owned by victims of intimate partner violence) from 2004 through 2019 and collect information on duration of stay, outcome, health problems, and expenses. Animals 229 animals cared for by the PetSafe program. Procedures Medical records were reviewed for information on species, breed, age, duration of stay, outcome of stay, client referral source, whether the animal had been cared for previously, health problems, medical interventions, and expenses incurred. Results There were 124 dogs, 95 cats, 6 ferrets, and 4 sugar gliders; 187 of the animals were returned to their owners, 37 were rehomed, and 5 were euthanized because of medical conditions. The most common health problems were dental disease and dermatological complaints (eg, flea infestation and resulting fleabite dermatitis). None of the animals had physical evidence of abuse. Mean duration of stay was 22 days (range, 1 to 93 days), and mean ± SD cost per animal was $368 ± $341. Clinical relevance Over the 16-year period of the study, the number and species of animals cared for by the PetSafe program at Purdue and the health problems encountered in those animals were relatively stable, and the program was able to meet the relatively predictable financial costs incurred through existing sources of funding.
Potential anti-inflammatory effects of nebulized local anesthetics on inhaled chlorine lung injury (834.8)

Chlorine (Cl2) is a chemical used in both industry and society alike, despite it being a highly irritant and reactive gas. Acute exposure can result in symptoms of airway obstruction such as wheezing, shortness of breath, mouth/nose/chest pain, and bronchospasm. Currently, there is no known antidote for chlorine’s poisoning effects. Potential treatments include topical exposure of the airways to nebulized drugs such as local anesthetics which have been shown to improve the mobility of monitored animals after exposure to Cl2 gas. In this research project, we assess the effects of the nebulized local anesthetics lidocaine (1% and 4%), 3% 2-Chloroprocaine following exposure to 100 or 400 ppm of chlorine gas on biochemical measurements of injury to airway. Wet-to-dry lung weight ratios, bronchoalveolar lavage (BAL) cell counts and total protein, and lung homogenate cytokine levels were determined 24 hours after Cl2 gas exposure and anesthetic treatment. In mice exposed to 400 ppm Cl2 gas, 1% lidocaine had the...
The effect of ventricular alternation on a summation gallop sound: Report of a case with left atrial and left ventricular intracardiac phonocardiograms

Abstract A patient with myocardial disease and pulsus alternans was found to have cyclic alternation in the intensity of a summation gallop sound recorded from the left ventricle. This sound was of greater amplitude immediately preceding the weaker beats. A reasonable explanation for the alternate waxing and waning of these vibrations makes use of the concept of Straub and the observations of more recent investigators that myocardial relaxation may be incomplete preceding the weaker beats of ventricular alternation.
Abstract 18989: Periprocedural Heparin Requirement in Patients Undergoing Atrial Fibrillation Ablation Stratified by Different Baseline Anticoagulation Regimens: Evidence for a Prothrombotic State With Interrupted Dabigatran

Introduction: Thromboembolic (TE) and bleeding complications represent the most common adverse events during atrial fibrillation (AF) ablation. In order to prevent TE, unfractionated heparin (UFH) is recommended throughout the procedure, with a target ACT of 350-400 sec. In this study we compared periprocedural heparin requirements during different pre-procedure anticoagulation regimens and the potential clinical implications. Methods: We retrospectively analyzed every case of AF ablation performed at our institution over the last 2 years, including only first time ablations, and collected the amount of UFH per kilogram needed to achieve the target ACT. The groups were compared based on the periprocedural anticoagulation strategy (warfarin vs. dabigatran vs. rivaroxaban), and the number of doses held before the procedure. Patients on warfarin were all on uninterrupted warfarin, but for comparison we further subdivided this group into INR tertiles, based on INR at time of procedure. Results: We included 58...
Real-time feedback on knee abduction moment does not improve frontal-plane knee mechanics during jump landings

Excessive knee abduction loading is a contributing factor to anterior cruciate ligament (ACL) injury risk. The purpose of this study was to determine whether a double-leg landing training program with real-time visual feedback improves frontal-plane mechanics during double- and single-leg landings. Knee abduction angles and moments and vertical ground reaction forces (GRF) of 21 recreationally active women were quantified for double- and single-leg landings before and after the training program. This program consisted of two sessions of double-leg jump landings with real-time visual feedback on knee abduction moments for the experimental group and without real-time feedback for the control group. No significant differences were found between training groups. In comparison with pre-training data, peak knee abduction moments decreased 12% post-training for both double- and single-leg landings; whereas peak vertical GRF decreased 8% post-training for double-leg landings only, irrespective of training group. Real-time feedback on knee abduction moments, therefore, did not significantly improve frontal-plane knee mechanics during landings. The effect of the training program on knee abduction moments, however, transferred from the double-leg landings (simple task) to single-leg landings (more complex task). Consequently, ACL injury prevention efforts may not need to focus on complex tasks during which injury occurs.
Circulating Lymphocyte Subpopulations in Crohn's Disease

Circulating lymphocytes were enumerated in 28 patients with Crohn's disease and in 12 patients with other diseases by rosetting and by immunofluorescent staining using monoclonal antibodies for Tcell surface phenotypic markers [OKT3 (mature), OKT4 (helper), and OKT8 (suppressor/cytotoxic)] or polyvalent antisera for surf ace immunoglobulins (B cells). Total lymphocyte counts were reduced only in those with non-steroid-treated active Crohn's disease. Circulating monocyte counts, proportions of peripheral T and B cells, and percentages and absolute numbers of mature, helper, and suppressor Tcell subclasses in Crohn's disease were not significantly different than in the controls. Helper to suppressor T-cell ratios were comparable in all subjects, varying directly with numbers of helper T cells (p
Cost Analysis and Long Term Planning Over the Lifecycle of an Enterprise Storage Solution

This document will cover the basics of Storage Area Networks (SAN), IP-Based Storage Networks such as NAS, and the basics of choosing a technology for an Enterprise Storage infrastructure. This document will focus on SAS (Serial Attached Storage) and SATA (Serial ATA) disk drive technologies. The primary focus for this document will be to aid a manager in making a purchasing decision for the selection of storage technologies. I will cover purchase options such as buy, lease, and lease-to-buy. This document will cover the basic costs associated with maintenance and upgrades over the lifetime of different storage technologies.
Aulacoseira stevensiae sp. nov. (Coscinodiscophyceae, Bacillariophyta), a new diatom from Ho Ba Bê, Bac Kan Province, Northern Viêt Nam

A new species of Aulacoseira Thwaites is described from piston core samples from Ho Ba Be in the karst region of northern Viet Nam. Although it closely resembles Aulacoaseira subborealis (Nygaard) Denys, Muylaert & Krammer, A. stevensiae Weide sp. nov. is designated a new species based mainly on morphological differences in the spines, including invariably inclined spines that are rounded, differences in the Ringleiste, areola pattern and overall size. Aulacoseira stevensiae is present throughout a core that spans the last 500 years. It was a major component of the diatom community, but the populations have recently decreased, possibly being outcompeted by Discostella Houk & Klee and Cyclotella (Kutzing) Brebisson species.
Speculations About the Indo-European Cardinals 5-10

SUMMARYOn the basis of some recent research in Indo-European phonology and morphology, it is suggested in this paper that the IE cardinals 5 to 10 were subject to affixation by non-singular markers. These markers, probably originating as quantitative enclitic adverbs, were added to these numerals in order to hypercharacterize their inherent non-singular meaning. Specifically, it is proposed that '5', '7', '8', '9', and '10' were all hypercharacterized by the suffix *-n, while '6' was hypercharacterized by the suffix *-s. In addition, dialectal data imply that within Indo-European '7' and '10' showed the non-singular element *-t, generally in contamination with *-n. Such an assessment represents a major departure from the traditional view that in Indo-European these numerals, with the exception of '8', were uninflected forms.RESUMECet article suggere, a la base de certaines recherches sur la pho-nologie et la morphologie indo-europennes, que les nombres cardinaux 5 a 10 en indo-europeen avaient ete soumis a une affixation avec des marqueurs 'non-singulier'. Ces marqueurs, venant probablement d'ad-verbes clitiques quantitatifs, ont ete ajoutes a ces chiffres afin de surcaracteriser leur sens inherent de 'non-singulier'. En particulier, il est propose que '5', '7', '8', '9' et '10' etaient tous surcaracte-rises par le suffixe *-n, tandis que '6' etait surcaracterise par le suffixe *-s, De plus, des donnees dialectales suggerent qu'a l'interi-eur de '7' et '10' indo-europeen il y avait l'element non-singulier *-t, generalement contamine avec *-n. Une telle analyse represente un ecart important par rapport avec 1'acceptation traditionnelle selon laquelle ces chiffres indo-europeens, a l'exception de '8!, etaient des formes sans flexion (i.e., invariables).ZUSAMMENFASSUNGIn diesem Aufsatz wird der Vorschlag gemacht, auf Grundlage jiing-ster Untersuchungen auf dem Gebiete der idg. Laut- und Formenlehre, das die idg. Kardinalzahlen 5 bis 10 'nicht-Singular' Merkzeichen in der Form eines Affixes trugen. Diese Merkzeichen, die wahrscheinlich in en-klitischen, quantitativen Adverbien ihren Ursprung haben, wurden diesen Ziffern beigefugt, urn ihre ihnen innewohnende nicht-singulare Bedeutung uberzubetonen. Insbesondere wird der Vorschlag gemacht, das die Ziffern '5', '7', '8', '9' und '10' alle durch das Suffix *-n ubercharakterisiert waren, wahrend dies im Falle von der Ziffer '6' durch Anfiigung von *-s geschah. Daruberhinaus legen es dialektale Daten nahe, das innerhalb des Indogermanischen die Ziffern '7' und '10' das nicht-singullire Element *-t aufwiesen, und zwar zumeist in Kontamination mit *~s. Eine sol-che Interpretation der Materialien bedeutet eine wichtige Abriickung von der traditionellen Auffassung, derzufolge diese Zahlworter des Indogermanischen, mit Ausnahme der '8', unflektierte Formen gewesen seien.