cssi/SciSciGPT-SciSciNet huggingface dataset:
Value creation in corporate asset sales: The role of managerial performance and lender monitoring

Abstract Examining stockholder and bondholder wealth of acquirers and sellers, we find that asset sales are firm value enhancing for the seller but value neutral for the acquirer. Although divestitures are typically viewed as more synergistic and friendly transactions than takeovers, we find using a matched acquirer–seller sample, that the net wealth effect from the transaction is not significantly different from zero. However, those transactions that involve high- q bidders and low- q sellers create maximum value for acquirers and for the transaction as a whole. Further, low- q bidder/low- q seller transactions are value destroying. We find that seller gains are only related to the seller’s managerial performance. We document that private lender monitoring enhances transactional value in corporate divestitures. Collectively, the analysis shows that well-managed and highly monitored firms are more likely to benefit from asset sale transactions.
Generalizing a Theorem of Wilber on Rotations in Binary Search Trees to Encompass Unordered Binary Trees

Wilber’s logarithmic lower bound, concerning off-line binary search tree access costs, is generalized to encompass binary trees that are not constrained to satisfy the search tree property. Rotation operations in this extended model can be preceded by subtree swaps. A separation between the power of processing with search trees versus unordered trees is demonstrated.
Failure Mechanics—Part II: The Central and Decisive Role of Graphene in Defining the Elastic and Failure Properties for all Isotropic Materials

Continuing from Part I (Christensen, 2014, “Failure Mechanics—Part I: The Coordination Between Elasticity Theory and Failure Theory for all Isotropic Materials,” ASME J. Appl. Mech., 81(8), p. 081001), the relationship between elastic energy and failure specification is further developed. Part I established the coordination of failure theory with elasticity theory, but subject to one overriding assumption: that the values of the involved Poisson’s ratios always be non-negative. The present work derives the physical proof that, contrary to fairly common belief, Poisson’s ratio must always be non-negative. It can never be negative for homogeneous and isotropic materials. This is accomplished by first probing the reduced two-dimensional (2D) elasticity problem appropriate to graphene, then generalizing to three-dimensional (3D) conditions. The nanomechanics analysis of graphene provides the key to the entire development. Other aspects of failure theory are also examined and concluded positively. Failure theory as unified with elasticity theory is thus completed, finalized, and fundamentally validated. [DOI: 10.1115/1.4028407]
EDFA-based DWDM lightwave transmission systems with end-to-end power and SNR equalization

An approximate analysis is presented which can be used to predict the performance of power and signal-to-noise ratio (SNR) equalization schemes when applied to dense wavelength-division multiplexing (DWDM) lightwave systems employing erbium-doped fiber amplifier (EDFA) cascades. Expressions are provided which relate the maximum number of amplifiers, EDFA gain imbalance, bit rate (R/sub b/), transmitter power, receiver dynamic range and number of channels. The relative advantages of these two equalization strategies are quantified by comparing the maximum number of amplifiers allowed by each scheme. It is shown that, while SNR equalization represents, on balance, the more desirable equalization strategy for future EDFA-based DWDM lightwave transmission systems, under certain conditions power equalization may be a better choice. When employing an APD receiver, for instance, power equalization can support 1.9 times more amplifiers than SNR equalization. However, when employing the more conventional preamplified PIN/FET receiver, SNR equalization can support 1.7 times more amplifiers than power equalization.
A Cognitive Metaphorical Analysis of Selected Verses in the Glorius Qu’ran

Metaphor has been generally contemplated and broke down inside the schema of verbal and written discourse, scholarly works and artistic studies. It has been identified with metaphorical language and has been viewed as quite recently a sort of aesthetic frivolity (Murray & Moon, 2006). In addition, conventional instructing of metaphors presents language as an abnormal or different method for using it (Goatly, 1997). Likewise, as Goatly has put it, scholars have needed figures of speech strictly limited to writing, talk and craftsmanship. Moreover, metaphor is viewed as something that fits in with abstract structures which is more concerned with novel or intriguing uses of words. Lakoff & Johnson (1980) presented an alternate idea and perspective of metaphor which is known as reasonable metaphorical dissection. The theory underlying this new approach is that the reasonable metaphors enter our understanding of our general surroundings and they shape our demeanor. Appropriately, as pointed out by Lakoff & Johnson (1980), metaphor is available in ordinary discourse, in every language, and is to a certain degree, has gotten to be culturally specific. Besides both contend that metaphors affect our way of viewing the meanings and are discovered widely in a significant number of our languages, contemplations and activities.
Reproductive Risk Factors in a Prospective Study of Breast Cancer: The Nurses' Health Study

A modification of the model of Pike et al. (Nature 1983;303: 767-70) was applied to 91,523 women in the Nurses' Health Study who did not report prevalent cancer initially and who were followed for 14 years (1,212,855 person-years and 2,341 incident breast cancers). The model took into account current age, age at all births, age at menopause, and age at menarche in predicting the annual and cumulative incidence of breast cancer. The authors found that ages both at first birth and at subsequent births have long-term influence on breast cancer incidence. The incidence density for parous women was greater than for nulliparous women for 20-30 years after the time of the first birth. However, cumulative incidence up to age 70 years was about 20% lower, 10% lower, or 5% higher for parous versus nulliparous women if their first birth was at age 20, 25, or 35 years, respectively. The authors also observed a significantly lower incidence after each additional birth as well as after menopause for women of the same age. Overall, the effect of reproductive factors (other than age at menarche) appears to influence cumulative incidence to age 70 years by a maximum of approximately 50% when women with multiple births with an early age at first birth are compared with women with a single birth at a late age.
Physical attractiveness in preschoolers: Relationships with power, status, aggression and social skills

Abstract Several lines of theory and research suggest that power (e.g., social dominance) and status (e.g., social prominence and positive peer regard) are enjoyed by those blessed with good looks. The present work addresses the relations among physical attractiveness, power, status, and aggression from a resource control theoretic perspective that suggests that group members find power holders physically attractive, even if they are aggressive. Teacher ratings of physical attractiveness, social dominance, peer reception, aggression, and social skills were collected on 153 preschoolers (3–6 years) from a Midwestern city. Positive peer regard was derived via sociometric nominations. Raters unfamiliar with the children assessed their physical attractiveness from photographs. Results show that teachers' perceptions of physical attractiveness are a function of power, status, and social skills. Additionally, teachers rated aggressive children who employ both prosocial and coercive strategies of resource control (bistrategic controllers) to be among the most physically attractive. These relations did not emerge for raters unbiased by children's behavior. Results suggest social dominance achieved via prosocial means begets attractiveness ratings, even if accompanied by high levels of aggression. The implications for intervention are discussed.
The sense lounger: establishing a ubicomp beachhead in elders' homes

In this paper we describe the Sense Lounger, a method for simply and cheaply turning a lounge chair into an initial "ubicomp" device in a home; providing a beachhead for transforming the home into a rich ubicomp environment. The Sense Lounger employs fabric sensors sewn into a chair's slipcover and force sensors on each leg to detect both an occupant and their activity. Drawing insights from user needs, we developed the Sense Lounger to (i) fit into the home and lifestyle of elders, (ii) assist and add value to the lives of elders, (iii) provide a platform for expanding assistive devices within the home environment. The current Sense Lounger prototype can be used to detect signs of life, patterns of use, posture, and sitting duration.
Child Maltreatment and Offending Behavior: Gender-Specific Effects and Pathways.

This study assessed the association between child maltreatment (ages 0—11) and offending behavior within gender-specific models. Prospectively collected data, including official measures of maltreatment and offending, were derived from the Chicago Longitudinal Study, a panel study of 1,539 low-income minority participants. Multivariate probit analyses revealed that maltreatment significantly predicted delinquency for males but not females yet forged a significant relation to adult crime for both genders. Exploratory, confirmatory, and comparative analyses suggested that mechanisms linking maltreatment to adult crime primarily differed across gender. For males, childhood-era externalizing behavior and school commitment along with adolescent-era socioemotional skills, delinquency, and educational attainment explained the maltreatment-crime nexus. For females, childhood-era parent factors along with adolescent indicators of externalizing behavior, cognitive performance, mobility, and educational attainment p...
A FIBER OPTIC SENSOR FOR HIGH RESOLUTION MEASUREMENT AND CONTINUOUS MONITORING OF VALVE GAPE IN BIVALVE MOLLUSCS

Abstract We describe a novel sensor based on fiber optic technology for fine scale (∼0.1 mm) laboratory measurements of valve gape in bivalve molluscs. We have illustrated the operation of this sensor by measuring valve gape in conjunction with depletion rate assays in the Eastern oyster (Crassostrea virginica, Gmelin 1791). The sensor is capable of accurate and repeatable measurements, with few of the drawbacks of other valve gape sensing methods (e.g., levers, strain gauges, electromagnetic sensors). This sensor technology can be applied to other systems requiring the measurement of axial distances while immersed in seawater or other harsh environments.
Abstract 16295: Human Epicardial Bipolar Electrograms Prolong and Reduce in Amplitude Prior to Induction of Peri-Operative Atrial Fibrillation and Are Related to Sites of High Electrogram Dominant Frequency in Sinus Rhythm

Background: The exact trigger/substrate interactions leading to post-operative AF are unknown. Sites of high DF in sinus rhythm are proposed to harbor ‘fibrillar myocardium’ or ‘AF nests’. We studied AF inducibility related to putative upstream substrate changes by characterising epicardial electrograms (EGM) in both time and frequency domains. Method: AF naive patients (n=14) undergoing coronary artery bypass grafting (CABG) had bipolar electrograms recorded from the lateral right atria (RA) wall with a high density spiral catheter, sampled at 1kHz. RA burst pacing at cycle lengths (CL) of 200, 500 and 1000ms was performed with any episodes of AF > 30s recorded. Electrograms were analysed using an average of 5 consecutive beats for duration, peak to peak amplitude, dominant frequency (DF) and activation time at all bipole pairs during every pacing drive train (total EGMs analysed 3430). Results: Bipolar EGM duration was significantly longer during AF (mean = 76.64ms, SD = 29.35ms) than all other CLs or N...
Ectopic expression of TAPETUM DETERMINANT1 affects ovule development in Arabidopsis

Plants have evolved to extensively employ leucine-rich repeat receptor-like kinases (LRR-RLKs), the largest family of RLKs, to control growth, development, and defense. In Arabidopsis thaliana, the EXCESS MICROSPOROCYTES1 (EMS1) LRR-RLK and its potential small protein ligand TAPETUM DETERMINANT1 (TPD1) are specifically required for anther cell differentiation; however, TPD1 and EMS1 orthologs also control megaspore mother cell proliferation in rice and maize ovules. Here, the molecular function of TPD1 was demonstrated during ovule development in Arabidopsis using a gain-of-function approach. In ovules, the EMS1 gene was primarily expressed in nucellus epidermis and chalaza, whereas the expression of TPD1 was weakly restricted to the distal end of integuments. Ectopic expression of TPD1 caused pleiotropic defects in ovule and seed development. RNA sequencing analysis showed that ectopic expression of TPD1 altered expression of auxin signaling genes and core cell-cycle genes during ovule development. Moreover, ectopic expression of TPD1 not only affected auxin response but also enhanced expression of cyclin genes CYCD3;3 and CYCA2;3 in ovules. Thus, these results provide insight into the molecular mechanism by which TPD1-EMS1 signaling controls plant development possibly via regulation of auxin signaling and cell-cycle genes.
A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits

Corticotrophin-releasing factor (CRF) is a 41 amino acid neuropeptide that coordinates adaptive responses to stress. CRF projections from neurons in the central nucleus of the amygdala (CeA) to the brainstem are of particular interest for their role in motivated behavior. To directly examine the anatomy and function of CRF neurons, we generated a BAC transgenic Crh-Cre rat in which bacterial Cre recombinase is expressed from the Crh promoter. Using Cre-dependent reporters, we found that Cre expressing neurons in these rats are immunoreactive for CRF and are clustered in the lateral CeA (CeL) and the oval nucleus of the BNST. We detected major projections from CeA CRF neurons to parabrachial nuclei and the locus coeruleus, dorsal and ventral BNST, and more minor projections to lateral portions of the substantia nigra, ventral tegmental area, and lateral hypothalamus. Optogenetic stimulation of CeA CRF neurons evoked GABA-ergic responses in 11% of non-CRF neurons in the medial CeA (CeM) and 44% of non-CRF neurons in the CeL. Chemogenetic stimulation of CeA CRF neurons induced Fos in a similar proportion of non-CRF CeM neurons but a smaller proportion of non-CRF CeL neurons. The CRF1 receptor antagonist R121919 reduced this Fos induction by two-thirds in these regions. These results indicate that CeL CRF neurons provide both local inhibitory GABA and excitatory CRF signals to other CeA neurons, and demonstrate the value of the Crh-Cre rat as a tool for studying circuit function and physiology of CRF neurons.
High-performance rendering of realistic cumulus clouds using pre-computed lighting

We present a new method for rendering realistic cumulus clouds in real time. The clouds in our approach consist of randomly rotated and scaled copies of a single reference particle. During the pre-processing, we pre-compute optical depth, single and multiple scattering inside the reference particle for every camera position, orientation and light direction, and store the information in the look-up tables. At run time, information from the look-up tables is used to compute the cloud shading, avoiding any ray marching or slicing. To control the level of detail, we introduce a new technique which provides high fidelity for close clouds while using a coarse representation for distant regions. In addition to this, we present a new method for blending particles. Compared to traditional alpha-blending, this method produces more accurate visual results by accounting for volumetric intersection. The method merges collection of individual particles into a continuous medium, and also eliminates temporal artifacts. Our technique is able to produce realistic images at high frame rates.
A Parallel Geometric Multifrontal Solver Using Hierarchically Semiseparable Structure

We present a structured parallel geometry-based multifrontal sparse solver using hierarchically semiseparable (HSS) representations and exploiting the inherent low-rank structures. Parallel strategies for nested dissection ordering (taking low rankness into account), symbolic factorization, and structured numerical factorization are shown. In particular, we demonstrate how to manage two layers of tree parallelism to integrate parallel HSS operations within the parallel multifrontal sparse factorization. Such a structured multifrontal factorization algorithm can be shown to have asymptotically lower complexities in both operation counts and memory than the conventional factorization algorithms for certain partial differential equations. We present numerical results from the solution of the anisotropic Helmholtz equations for seismic imaging, and demonstrate that our new solver was able to solve 3D problems up to 6003 mesh size, with 216M degrees of freedom in the linear system. For this specific model problem, our solver is both faster and more memory efficient than a geometry-based multifrontal solver (which is further faster than general-purpose algebraic solvers such as MUMPS and SuperLU_DIST). For the 6003 mesh size, the structured factors from our solver need about 5.9 times less memory.
An adaptive method with mesh moving and mesh refinement for solving the Euler equations

We discuss mesh moving, local mesh refinement, and static mesh regeneration that are used with MacCormack's finite difference scheme to solve the Euler equations in two space dimensions. A coarse base mesh of quadrilateral cells is moved by an algebraic mesh movement function so as to follow and isolate spatially distinct phenomena. The local mesh refinement method recursively divides the time step and spatial cells of the moving base mesh in regions where the error estimates are high until a prescribed error tolerance is satisfied. The error estimation is based upon estimates of the local discretization error obtained by Richardson's extrapolation. A static mesh regeneration procedure is used to create the initial base mesh and a new base mesh when the existing one becomes too distorted through mesh movement. MacCormack's scheme is given total variation diminishing (TVD) artificial viscosity in order to compute shocks and discontinuities. The time step is adjusted automatically to maintain stable computation. Results are presented for a computational example.
Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis.

Background Expression of TL1A (tumor necrosis factor-like ligand 1A) is increased in patients with inflammatory bowel disease (IBD). Mice with elevated T-cell expression of Tl1a (L-Tg) have increased regulatory T cells, yet develop worsened colitis and intestinal fibrosis. The aim of this study was to investigate the role of Tl1a in the differentiation and function of Tregs and their effects in modulating murine colitis. Methods Tl1a overexpressing L-Tg, Foxp3-mRFP (FIR)-LTg, and DR3KO-LTg mice were used for the study. In the L-Tg mice, Tl1a expressing cells can be identified by green fluorescent protein (GFP). Results We report that Foxp3 expression in the L-Tg mice is variable based on high or low level of Tl1a expression, referred to herein as GFPhigh and GFPlow T cells. Treg-specific suppressive molecules were highly expressed on the GFPlow Foxp3 Tregs and were significantly reduced on Tregs expressing high Tl1a. In vitro suppression function was significantly enhanced in the GFPlow compared with the GFPhigh Tregs. RAG mice cotransferred with either GFPlow or wild-type Tregs were protected from colitis. Furthermore, GFPlow Tregs lost the suppression function in the absence of DR3 (Death receptor 3). Conclusions Tregs expressing low levels of Tl1a ameliorate murine colitis and promote the maintenance of Treg suppressor function in a DR3-dependent manner, partly due to a heightened regulatory program. These data reveal novel roles for differential levels of Tl1a in regulating T cell-mediated immune responses that have implications in understanding the pathogenesis of IBD.
Analgesic and anti-inflammatory effects of orally given streptokinase.

According to Lewis(1), the nonapeptide bradykinin is an important mediator of the acute inflammatory reaction. It is, therefore, of interest that orally given proteases were recently shown to antagonize 3 pharmacologic actions of bradykinin: vasodilatation, vascular permeability and smooth muscle contraction(2). The objects of the present investigation were: first, to assess the action of orally given streptokinase against the fourth pharmacologic action of bradykinin, namely, pain production; and second, to appraise the anti-inflammatory action of orally given streptokinase in a controlled animal and clinical experiment.Methods. 1. Analgesia study. The cantharidin blister technic of Armstrong et al. (3) was slightly modified. This study comprised 30 apparently healthy students and technicians. A band-aid containing 2 drops of tincture cantharidin was applied to the skin of the flexor surface of the forearm the evening before the day of the experiment. When the band-aid was removed the next morning, the a...
Tax-Loss Selling: Evidence from December Stock Returns and Share Shifts

This article develops a variety of new evidence on tax-loss selling and the January effect. Individual stocks are divided into categories depending on a tax-loss measure. By November, a given year can be categorized as a high tax loss or a low tax loss year. I find that December returns are significantly lower in high tax loss years than in low tax loss years. The subsequent January returns are higher in high tax loss than in low tax loss years. These effects hold across stocks of all sizes but grow in amount as stocks become smaller. The January increases are roughly the size of the December decreases. Tax-loss selling explains about one-half the January effect. Even following low tax loss years, the January effect is present. The size and tax loss effects across individual stocks depend on whether the year is a high tax loss or a low tax loss year. In low tax loss years, there is no size effect and no tax loss selling effect. I hypothesize that these effects occur because the public shifts shares to dealers in December, the tax-loss selling season. Data on Exchange member and nonmember transactions support this hypothesis. Over 60 percent of the temporal variation in the small firm January returns is explained by variation in end-of-year share shifts.
A new acellular tissue scaffold of Porcine thoracic aorta:preparation and evaluation

Objectives:To investigate the method of preparing a new acellular tissue scaffold of porcine thoracic aorta. Methods: One hundred and fifty fresh thoracic aorta specimens from chinese experiment swine with similar body weight were divided into five groups: fresh thoracic aorta group, decellularisation group with ultrasound wave (90 kW) and TritonX-100, decellularisation group with ultrasound wave(135 kW) and TritonX-100, decellularisation group with ultrasound wave(180 kW) and TritonX-100 and decel- lularisation group with TritonX-100. The histopathology and microstructure of these processed aortic tissues were studied with light microscope and scanning electronic microscope. As biomarkers of extracellular matrix, laminin and fibronectin on the processed tissue specimen were stained with immunohistochemical methods. In addition, the biomechanic properties and heat shrinkage properties of tissue specimen in each group were studied and compared. Results:In the acellular scaffold group prepared with ultrasound wave and TritonX-100, cells could be removed thoroughly,tissue structure and biomechanics were normal, and conservation of LN and FN was better than traditional chemical decellularisation methods. Conclusion:The new tissue scaffold prepared with ultrasound wave and TritonX-100 would be better than that with traditional chemical decellularisation methods. It could be a superior method in processing acellular thoracic aortic scaffold.
Introduction to the 2016 Keith L. Parker Memorial Lecturer: Douglas M. Stocco, Ph.D.

Douglas M. (Doug) Stocco is Professor Emeritus at Texas Tech University Health Sciences Center in Lubbock, TX, and is internationally renowned for his work characterizing the steroidogenic acute regulatory protein, StAR. Stocco's laboratory isolated and cloned StAR from mouse Leydig MA-10 cells, collaborated on the demonstration that StAR mutations cause congenital lipoid adrenal hyperplasia, and delineated much of what is known about the intracellular pathways that regulate its production. This work resolved a decades-long quest to identify the mechanism underlying the acute regulation of steroidogenesis.
Abstract 1117: Dissection of the major hematopoietic quantitative trait locus in chromosome 6q23.3 identifies miR-3662 as a player in hematopoiesis and AML

Background: Over 15 genome-wide association studies (GWASs) have identified a narrow region in chromosome 6q23.3 as a major hematopoietic quantitative trait locus (QTL) for many hematologic traits. The associated phenotypes have yet to be fully explained by genes in the region, including MYB. We noted a newly annotated microRNA within the QTL, miR-3662, and sought to characterize its role in the QTL by exploring its function in normal and malignant hematopoiesis, specifically acute myeloid leukemia (AML). Results: To assess the association between the QTL-defining SNPs and miR-3662 abundance, we genotyped 10 GWAS SNPs in 200 blood samples from non-leukemic individuals. The risk alleles of all 10 SNPs associated with higher miR-3662 abundance. Homozygosity for rs66650371, a three base pair (bp) deletion, showed the strongest association (P To explore the role of miR-3662 in malignant hematopoiesis, we overexpressed miR-3662 in AML cell lines (Kasumi1, KG1a, MV4-11) and primary AML patient blasts (n = 12). Overexpression of miR-3662 reduced cell growth and viability in vitro, and significantly reduced tumor size in a murine xenograft model (scramble vs. miR-3662; n = 9 mice/group). We used targeted RNA sequencing to identify differentially expressed genes between forced miR-3662-expresssing- and control AML patient blasts using a panel of 361 candidate genes (TruSeq RNA platform, Illumina). IKBKB was identified as a promising target, and direct regulation of IKBKB9s 3′-UTR by miR-3662 was confirmed via luciferase assay. MiR-3662 overexpression lowered IKBKB mRNA and protein expression in both HPCs and AML patient blasts. As IKBKB promotes activation and nuclear localization of NF-κB, overexpression of miR-3662 led to decreased NF-κB transactivation potential via luciferase assay. Confocal microscopy of HPCs and AML cells, as well as subcellular fraction immunoblots, revealed decreased NF-κB nuclear localization upon miR-3662 overexpression. Re-introduction of IKBKB partly rescued miR-36629s phenotype by increasing nuclear localization of NF-κB, decreasing growth of HPCs, and increasing viability of AML cells. Conclusion: The risk alleles of the 6q23.3 region associated with higher miR-3662 abundance, and miR-3662 abundance was functionally linked to rs66650371. We characterized miR-3662 as an agent in normal and malignant hematopoiesis, and demonstrated that miR-3662 reduces NF-κB activity by targeting IKBKB. Citation Format: Sophia E. Maharry, Christopher J. Walker, Sandya Liyanarachchi, Sujay Mehta, James S. Blachly, Denis C. Guttridge, Clara D. Bloomfield, Albert de la Chapelle, Ann-Kathrin Eisfeld. Dissection of the major hematopoietic quantitative trait locus in chromosome 6q23.3 identifies miR-3662 as a player in hematopoiesis and AML. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1117.
Enabling city-scale multi-energy optimal dispatch with energy hubs

This paper further extends the class of energy hubs that can be modeled with a concise system description and in a computationally efficient optimization framework to permit rapid analysis of multi-energy systems. The new hub models are then embedded in the multi-energy system analysis tool Hubert and solves the multi-period optimal dispatch (MPOD) problem for a broad class of energy hub systems. Specifically, this paper presents recent improvements developed for Hubert, including the use of piece-wise linear modeling to capture nonlinear converter efficiencies, limits on hub component outputs to reflect physical limits of converters, and hub emission limits. These developments enable appropriate modeling of multi-energy micro-grids and cities and are illustrated with a multi-energy model of The University of Vermont's campus under different capital planning scenarios and modeling assumptions. Interestingly, the shortcomings of using a traditional constant-efficiency hub converter model are illustrated with an energy storage sizing application for multi-energy systems. It is shown that the traditional hub models can significantly undersize energy storage as compared to the more accurate piece-wise linear energy hub formulation.
Engineered T cells: the promise and challenges of cancer immunotherapy

The immune system evolved to distinguish non-self from self to protect the organism. As cancer is derived from our own cells, immune responses to dysregulated cell growth present a unique challenge. This is compounded by mechanisms of immune evasion and immunosuppression that develop in the tumour microenvironment. The modern genetic toolbox enables the adoptive transfer of engineered T cells to create enhanced anticancer immune functions where natural cancer-specific immune responses have failed. Genetically engineered T cells, so-called 'living drugs', represent a new paradigm in anticancer therapy. Recent clinical trials using T cells engineered to express chimeric antigen receptors (CARs) or engineered T cell receptors (TCRs) have produced stunning results in patients with relapsed or refractory haematological malignancies. In this Review we describe some of the most recent and promising advances in engineered T cell therapy with a particular emphasis on what the next generation of T cell therapy is likely to entail.
Non-linearity test of an accelerometer system designed for the seismic near-field measurement

An accelerometer system designed for the seismic near-field measurement is described. The wide dynamic range of the system, and the anticipated acceleration spectral density require that the accelerometers be highly linear. A method for determining the linearity is described.
Nutritional Nightmare: Hypoparathyroidism Secondary to Celiac Disease

Abstract Idiopathic hypoparathyroidism is a rare and probable late disease associated with celiac disease that could be the result of endomysial antibody molecular cross-reactivity with parathyroid gland cells. It is possible that the length of exposure to these antibodies increases the risk for hypoparathyroidism. We present a case of symptomatic idiopathic hypoparathyroidism not controlled with outpatient calcium replacement therapy later discovered to have concomitant celiac disease.
Can alternative service delivery save cities after the Great Recession? Barriers to privatisation and cooperation

Cities continue to face fiscal challenges after the Great Recession and alternative service delivery is being emphasised as a solution. How promising is alternative service delivery as a solution a...
A Phenomenological Exploration of Bhutanese Counselors’ Experiences with Western Counseling

Bhutan has recently invited the profession of counseling to aid in responding to growing mental health problems, social and family issues, and school and career guidance needs. This study is a phenomenological investigation of the experiences of Bhutanese counselors with Western counseling in order to understand the cultural fit between Bhutan and Western counseling orientations. Eleven participants were interviewed and four themes identified: conceptualization of counseling, Bhutanese culture, Bhutanese counseling, and the relationship between Western counseling and Bhutan. Suggestions are made for a potential model of Bhutanese counseling, counselor training, ongoing Western contributions, and the further development of the counseling profession.
RHEED Reflection Mode

Before we discuss analysis of film textures by the x-ray pole figure and reflection high-energy electron diffraction (RHEED) pole figure (transmission mode) techniques, we present in this chapter a more familiar use of RHEED, the reflection mode. This technique has been used extensively for the determination of surface structure and for studies of surface ordering. It is most useful for surfaces that possess a decent long-range order with perhaps some extended defects such as surface steps. X-ray can also be used for these purposes with a glancing incidence diffraction geometry, but it would require a very intense source such as synchrotron radiation. In this chapter, we discuss kinematic treatment of electron scattering and the formulation of angular intensity distribution in both layer-by-layer and multilayer growths. More extensive discussion of RHEED in the transmission mode will be presented in Chaps. 6 and 7.
Seasonal Patterns of Agricultural Day-Labour at Eight English Farms, 1835–1844

Burnette examines the seasonality of employment and wages for day-labourers at eight farms throughout England in the period 1835–1844. She measures the number of days worked by men, boys and female workers each week of the year. Most employment peaks occurred either at the hay-harvest or at the corn harvest, and peak employment was anywhere from 40 to 190 per cent more than average employment. Some farms used migrant labour for harvest, some used the labour of women and children and some relied on local men. Male wages were highly seasonal in Norfolk, rising 83 per cent during harvest, but were less seasonal elsewhere. At some farms, wages changed little during harvest. Changes in wages were not strongly correlated with changes in employment.
Choosing Wisely in Critical Care: Results of a National Survey From the Critical Care Societies Collaborative.

Objectives:Over-utilization of tests, treatments, and procedures is common for hospitalized patients in ICU settings. American Board of Internal Medicine Foundation’s Choosing Wisely campaign tasked professional societies to identify sources of overuse in specialty care practice. The purpose of this
ECS Dynamism and Its Influence on Neuronal Excitability and Seizures.

Seizure activity is governed by changes in normal neuronal physiology that lead to a state of neuronal hyperexcitability and synchrony. There is a growing body of research and evidence suggesting that alterations in the volume fraction (α) of the brain’s extracellular space (ECS) have the ability to prolong or even initiate seizures. These ictogenic effects likely occur due to the ECS volume being critically important in determining both the concentration of neuroactive substances contained within it, such as ions and neurotransmitters, and the effect of electric field-mediated interactions between neurons. Changes in the size of the ECS likely both precede a seizure, assisting in its initiation, and occur during a seizure, assisting in its maintenance. Different cellular ion and water transporters and channels are essential mediators in determining neuronal excitability and synchrony and can do so through alterations in ECS volume and/or through non-ECS volume related mechanisms. This review will parse out the relationships between how the ECS volume changes during normal physiology and seizures, how those changes might alter neuronal physiology to promote seizures, and what ion and water transporters and channels are important in linking ECS volume changes and seizures.
The Higher Education “Crisis” and Political Science

The Road Ahead for America’s Colleges and Universities. By Robert B. Archibald and David H. Feldman. New York: Oxford University Press, 2017. 290 p. $29.95.Robot-Proof: Higher Education in the Age ...
Nietzsche's Free Spirit Works: A Dialectical Reading

Between 1878 and 1882, Nietzsche published what he called 'the free spirit works': Human, All Too Human; Assorted Opinions and Maxims; The Wanderer and His Shadow; Daybreak; and The Gay Science. Often approached as a mere assemblage of loosely connected aphorisms, these works are here re-interpreted as a coherent narrative of the steps Nietzsche takes in educating himself toward freedom that executes a dialectic between scientific truth-seeking and artistic life-affirmation. Matthew Meyer's new reading of these works not only provides a more convincing explanation of their content but also makes better sense of the relationship between them and Nietzsche's larger oeuvre. His argument shows how these texts can and should be read as a unified project even while they present multiple, in some cases conflicting, images of the free spirit. The book will appeal to anyone who is interested in Nietzsche's philosophy and especially to those puzzled about how to understand the peculiarities of the free spirit works.
Influence of brønsted-acid and cation-exchange sites on ethene adsorption in ZSM-5

Abstract Differential heats of adsorption were measured for ethane and ethene on a siliceous ZSM-5, H-[Al]ZSM-5, H-[Fe]ZSM-5, Li-[Al]ZSM-5, H(Zn)-[Al]ZSM-5, and H(Zn)-[Fe]ZSM-5 at 195 K in order to characterize the nature of interactions between the olefin functional group and both Bronsted sites and exchanged metal cations. On siliceous ZSM-5, the differential heats for ethane and ethene were both 31 ± 1 kJ/mol, independent of coverage. While the additional interaction of ethane with Li and Zn-cation sites was negligible and only about 2 kJ/mol with Bronsted sites, the additional heats of adsorption for ethene were negligible on Li sites, 8 kJ/mol on Bronsted sites, and 14 kJ/mol Zn sites. Results were similar for exchanged [Al]ZSM-5 and [Fe]ZSM-5. Density functional theory calculations with different dispersion-corrected generalized gradient approximation functionals correctly predict the increased interaction of ethene with acid sites but overestimate the strength of interaction of proton and Li with C C double bonds.
Relative accuracy of anthropometric-based body fat equations in males and females with varying BMI classifications.

Summary Background BMI based body fat equations developed from Womersley and Durnin (BMIWO), Jackson et al. (BMIJA), Deurenberg et al. (BMIDE), and Gallagher et al. (BMIGA) are commonly used to quantify body fat percentage (BF%). However, relative fat mass (RFM) is a new anthropometric-based method that has been proposed as an alternative. Aims The purpose of this study was to examine the independent and interactive effects of sex and BMI classification on the relative accuracy of BMI-based body fat equations and RFM. Methods Males (n = 75) and females (n = 75) were stratified and classified into three different groups; 1) normal weight (n = 50 [NW: 50% males]; BMI Results A significant SEX × BMI interaction was detected for all comparisons (all p Conclusions The current findings highlight that RFM does not appear to overcome error commonly associated with BMI-based body fat equations when stratifying by sex and BMI classification. Nonetheless, practitioners can use BMIWO, BMIDE, and RFM in males and females classified as NW or OB, but should employ caution prior to use in OW persons.
E-067 Endovascular occlusion of a carotid cavernous arteriovenous fistula complicated with posterior communicating artery-sphenoparietal sinus fistula: a case report, technical consideration, and literature review

Background Traumatic injury of the posterior communicating artery causing arteriovenous fistula is rare. Here, we present a complicated case in which a patient presented with a traumatic carotid-cavernous fistula and subsequently developed recurrence. Recurrence was complicated by shunting of the posterior communicating artery to the sphenoparietal sinus post-treatment that was successfully treated endovascularly. Method A 53-year-old male with a remote history of head trauma complicated by posttraumatic right cavernous carotid fistula presented with progressive headaches. He was treated at another facility via trans-superior ophthalmic vein coil embolization several years prior.CT angiography demonstrated recurrence with a complex fistula. Further investigation via cerebral angiogram demonstrated a type A direct high flow cavernous-carotid fistula with cortical venous drainage and multiple venous aneurysms. Result The fistula was treated by R ICA deconstruction with coil and Onyx embolization after a balloon occlusion test. Follow up MRI after one year suggested a continued low-pressure fistula. He subsequently underwent cerebral angiogram which showed an indirect fistula, with feeders from ethmoidal arteries and branches of the internal maxillary artery. Outflow was through the sphenoparietal sinus. There was a direct fistula communication in between the posterior communicating artery and fistula outflow. Via the R PCommA, the fistula outflow was embolized using coils and Onyx with almost complete obliteration of the fistula and minimal to no reflux into the right posterior communicating artery. The patient did well postoperatively with complete resolution of headaches and was seen recently in clinic for 6 months follow up visit. Conclusion We present a patient with carotid-cavernous arteriovenous fistula complicated by subsequent fistula between the posterior communicating artery and sphenoparietal sinus successfully endovascularly treated with complete obliteration of the fistula without reflux. To our knowledge, this is the first such report. We present this case to review the multiple challenges of managing complicated traumatic carotid cavernous arteriovenous fistula and to highlight the utility of endovascular intervention in their treatment. Disclosures M. Mathkour: None. J. Berry: None. E. McCormack: None. E. Valle-Giler: None.
Flexible MM-wave dielectric waveguides

Flexible dielectric waveguides have been demonstrated at 10 GHz and 94 GHz by filling hollow, low-dielectric-constant polymer tubes with low-loss, high-dielectric-constant powders. Flexible guides with losses as low as 0.12 dB/cm were demonstrated at 94 GHz. These guides also exhibited negligible bending loss for radii of curvature greater than 4 cm.
On the sufficiency of pairwise interactions in maximum entropy models of networks

Biological information processing networks consist of many components, which are coupled by an even larger number of complex multivariate interactions. However, analyses of data sets from fields as diverse as neuroscience, molecular biology, and behavior have reported that observed statistics of states of some biological networks can be approximated well by maximum entropy models with only pairwise interactions among the components. Based on simulations of random Ising spin networks with p-spin ( $$p>2$$ ) interactions, here we argue that this reduction in complexity can be thought of as a natural property of densely interacting networks in certain regimes, and not necessarily as a special property of living systems. By connecting our analysis to the theory of random constraint satisfaction problems, we suggest a reason for why some biological systems may operate in this regime.
Single Port Laparoscopic Total Colectomy

Single port laparoscopic surgery (SPS) is an alternative to traditional laparoscopy and open surgery for performing a total abdominal colectomy. Studies suggest that the SPS approach is safe and has comparable outcomes to traditional laparoscopy for this operation.The goal of this chapter is for the reader to gain a familiarity with single incision laparoscopic total colectomy. We describe the indications for SPS, pre-operative assessment of patients, and routine post-operative care. We also provide a detailed step-by-step approach to the operation with images. The reader will also benefit fromtroubleshooting advice at each step. We hope to increase the readers familiarity with our approach to this minimally invasive procedure.
RE: Racial and Ethnic Disparities in Multisystem Inflammatory Syndrome in Children.

We read with interest the article “Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome” by Javalkar et al.1 Multisystem inflammatory syndrome in children (MIS-C) is a potentially fatal complication of severe acute respiratory syndrome coronavirus 2 infection (coronavirus disease 2019 [COVID-19]) because patients can develop myocarditis, coronary artery abnormalities, arrhythmias, myocardial ischemia, cardiogenic shock, and death.2 Javalkar et al demonstrated that children in Massachusetts with lower socioeconomic status and higher social vulnerability index (SVI) had higher odds of developing MIS-C and that, of the children with lower socioeconomic status and higher … E-mail: aamartin{at}dmc.org
Continuing education needs in clinical geropsychology: The practitioners' perspective.

Abstract Presently, older adults are under-served by psychologists. In part this reflects a lack of psychologists proficient in clinical geropsychology to provide appropriate treatment. The present study provides information gathered from practitioners for planning continuing education programs in clinical geropsychology. The findings describe the characteristics of clinicians pursuing additional training to work with older adults, and their topical preferences and training needs to guide future continuing education offerings. In addition, the practitioners' opinions regarding a possible credential recognizing competence in clinical geropsychology are discussed.
A localized symplectic model reduction technique for parameterized Hamiltonian systems

In this article, a localized symplectic model reduction technique, locally weighted proper symplectic decomposition (LWPSD), is proposed to simplify parameterized Hamiltonian systems. Our aim is two-fold. First, to achieve computational savings for large-scale Hamiltonian systems with parameter variation. Second, to preserve the symplectic structure of the original system. As an analogy to the proper orthogonal decomposition, the proper symplectic decomposition (PSD) can be used to construct a symplectic subspace to fit empirical data, and yield a low-order Hamiltonian system on the subspace. Instead of using a global basis to construct a global reduced model, the locally weighted approach approximates the original system by multiple lower-dimensional subspaces. Each local reduced basis is generated by the PSD of a weighted snapshot ensemble. Compared with the standard PSD, the LWPSD could yield a more accurate solution with a fixed subspace dimension. The stability, accuracy, and efficiency of the proposed technique are illustrated through the numerical simulation of the wave equation.