cssi/SciSciGPT-SciSciNet huggingface dataset:
Design of a model to predict surge capacity bottlenecks for burn mass casualties at a large academic medical center.

OBJECTIVES: To design and test a model to predict surge capacity bottlenecks at a large academic medical center in response to a mass-casualty incident (MCI) involving multiple burn victims. METHODS: Using the simulation software ProModel, a model of patient flow and anticipated resource use, according to principles of disaster management, was developed based upon historical data from the University Hospital of the University of Michigan Health System. Model inputs included: (a) age and weight distribution for casualties, and distribution of size and depth of burns; (b) rate of arrival of casualties to the hospital, and triage to ward or critical care settings; (c) eligibility for early discharge of non-MCI inpatients at time of MCI; (d) baseline occupancy of intensive care unit (ICU), surgical step-down, and ward; (e) staff availability-number of physicians, nurses, and respiratory therapists, and the expected ratio of each group to patients; (f) floor and operating room resources-anticipating the need for mechanical ventilators, burn care and surgical resources, blood products, and intravenous fluids; (g) average hospital length of stay and mortality rate for patients with inhalation injury and different size burns; and (h) average number of times that different size burns undergo surgery. Key model outputs include time to bottleneck for each limiting resource and average waiting time to hospital bed availability. RESULTS: Given base-case model assumptions (including 100 mass casualties with an inter-arrival rate to the hospital of one patient every three minutes), hospital utilization is constrained within the first 120 minutes to 21 casualties, due to the limited number of beds. The first bottleneck is attributable to exhausting critical care beds, followed by floor beds. Given this limitation in number of patients, the temporal order of the ensuing bottlenecks is as follows: Lactated Ringer's solution (4 h), silver sulfadiazine/Silvadene (6 h), albumin (48 h), thrombin topical (72 h), type AB packed red blood cells (76 h), silver dressing/Acticoat (100 h), bismuth tribromophenate/Xeroform (102 h), and gauze bandage rolls/Kerlix (168 h). The following items do not precipitate a bottleneck: ventilators, topical epinephrine, staplers, foams, antimicrobial non-adherent dressing/Telfa types A, B, or O blood. Nurse, respiratory therapist, and physician staffing does not induce bottlenecks. CONCLUSIONS: This model, and similar models for non-burn-related MCIs, can serve as a real-time estimation and management tool for hospital capacity in the setting of MCIs, and can inform supply decision support for disaster management. Abir M , Davis MM , Sankar P , Wong AC , Wang SC . Design of a model to predict surge capacity bottlenecks for burn mass casualties at a large academic medical center. Prehosp Disaster Med. 2013;28(1):1-10. Language: en
SpriteDB Tool A Web-Tool for Comparing Sprite Generation Results

SpriteDB tool has two main objectives. Firstly, it provides an open-source, uniform platform for accessing a vast collection of test videos used for sprite generation. Secondly, it presents the experiments with intermediate results generated by our approach for comparison and analysis. Our experimental results consist of classification of videos for sprite generation, synthetic and ground truth video generation, and the generated sprites.
Comparative Study of Pedestrian Accessibility to Transit Stations Using Free and Proprietary Network Data

Availability of a transit service is a key factor in a traveler's choice of transportation mode. Transit service is a realistic option only if the service is available at or near locations when a person plans to travel. Whereas various measures exist for transit availability such as service frequency, the focus of this study was on the spatial aspect of pedestrian accessibility to transit stations, that is, on service coverage. Service areas are commonly used to visualize accessibility for pedestrians to transit systems and to analyze the potential ridership. Because the service area for a station is defined over the maximum network walking distance from a transit station, a complete street network that includes pedestrian segments, that is, shortcuts, is highly important for a realistic assessment of service areas. Whereas most proprietary geodata providers concentrate solely on car-related geodata, public domain street data and volunteered geographic information, such as OpenStreetMap, provide a potenti...
Marketing and Product Description: Value Added in the Real Estate Market

We consider the effect of marketing expertise on economic transactions, with a particular focus on the real estate market. We show that even as listing information becomes increasingly accessible on real estate aggregation websites, realtor expertise remains important in securing a desirable sale price. One main channel for the effects of such expertise is improving information dissemination to potential buyers through higher quality listings. Using listing photos and remarks as measures of quality, we find that realtor activity is correlated with significantly higher quality listings. We then measure the price impact of these measures of quality and find that, even after controlling for a large spectrum of house characteristics, listing quality is correlated with higher sale prices.
Applications to the calculus of variations

The theory developed in this chapter is based on the concept of the integral $$\left\langle {\Phi ,T} \right\rangle = \int_T {\Phi = \int {\Phi \left[ {z,\vec T\left( z \right)} \right]} d\left\| T \right\|z}$$ of a parametric integrand Ф of degree m over an m dimensional rectifiable current T defined in 5.1.1, on the concept of ellipticity defined in 5.1.2, and on the notions of minimizing current defined in 5.1.6. For example, a current S ∈ ℛ m(R n ) is absolutely Ф minimizing with respect to R n if and only if $$\left\langle {\Phi ,S} \right\rangle \le \left\langle {\Phi ,T} \right\rangle {\rm{for}}\,{\rm{all}}\,T \in {R_m}\left( {{R^n}} \right)\,{\rm{with}}\,\partial {\rm{S = }}\partial {\rm{T}}{\rm{.}}$$
Antigen-Antibody Interaction

Serology is the study of the in vitro reaction of antibodies in blood serum with antigens, i.e., usually those of microorganisms inducing infectious disease. Precipitation, agglutination, and complement fixation are serological methods used in diagnosis and research.
Racism as 'The National Crucial Sin': Theology and Derrick Bell

The Article probes a paradox that lies at the heart of the work of critical race scholar Derrick Bell. Bell claims on the one hand that racism is permanent, and yet on the other he argues that the fight against racism is both necessary and meaningful. Although Bell's thesis of racism's permanence has been criticized for rendering action for racial justice unavailing, the Article advances an understanding of Bell that supports and defends the integrity of his paradox. The Article draws upon the work of Protestant theologian Reinhold Niebuhr and Niebuhr's paradox that social action is both necessary and meaningful despite the inextricable presence of human sin. The argument is that the dynamics of the relation between sin and action may illuminate the dynamics of the relation between racism and action. One need not necessarily agree with Niebuhr's theology to find the lived experience he describes a potentially rich source of understanding for the paradox that Bell maintains.
Sequence of E. coli tRNA-Glu1 by automated sequential degradation.

Abstract A minor tRNA-Glu1 constituent of a preparation of E. coli B tRNA-Glu (Oak Ridge) has a guanosine residue at position 66 rather than an adenosine as in the tRNA-Glu2 described by Ohashi et al. (3). Automated sequential degradation was used to sequence this region.
Exemptions for Religion Contained in Regulatory Statutes

Discussions of the relation of religion and secular law of the United States often center on constitutional controversies arising out of the Religion Clauses of the First Amendment. That narrow focus, however, overlooks the practical and conceptual importance of the thousands of ways in which sub-constitutional sources of law such as statutes and common law rules also play a defining role in mapping the boundaries of civil and religious authority. This encyclopedia entry discusses, in particular, the many federal and state statutes that explicitly provide religious institutions and religiously-motivated individuals with exemptions from otherwise applicable secular law. Such statutes seek, variously, to accommodate religious conscience, recognize the relevance of religious norms, minimize intrusion into religious life, acknowledge religious diversity, adjust regulatory regimes to take religious facts into account, or simply oblige religious interest groups. Exemption statutes have been criticized on various grounds, and sometimes pose particular difficulties, though courts have generally indicated that they are not unconstitutional simply for setting out distinctive legal treatment for religion and religious persons. In any event, their existence and variety is a vital feature of the legal landscape of religion in the United States whose practical significance and larger meaning needs to be appreciated and understood. They also suggest, especially in the light of the recent constriction of the constitutional doctrine of free exercise, a particular legislative capacity, not only to respect religious conscience but to recognize, in an almost political sense, the diversity and dignity of non-state normative perspectives. This entry does not attempt an exhaustive account of statutory exemptions. It does try to provide a framework for considering a range of examples, and to suggest how such provisions illuminate the law's effort to understand and accommodate the reality of religious life.
What educators need to know about where openGL is and where it is going

OpenGL has undergone major transitions in the last 5 years. Some functionality has been "deprecated". Shaders have both core and compatibility modes. Compute Shaders have been added. And, now we hear about a project that started out being called glNext, and now is called Vulkan. When OpenGL started in 1992, educators found it easy to understand and teach. This is not the case anymore. It is difficult to figure out what pieces of OpenGL to include in various levels of computer graphics courses. This tutorial will make sense of all these issues and give advice on what is worth teaching to what level of students. This tutorial will present class notes that educators can adapt to explain these concepts to their own students in their own classes.
Laboratory Evaluation of the Recent Fungicides for Sapatain and Lumber Mold by JWPA test method

22種類の原体成分からなる単一あるいは2～3種混合の,最近の木材用防かび剤について実験室的な防かび効力試験を行った。試験は,本邦では未発売の開発途上にある6種類の新規薬剤と,すでに市場にある20種類の薬剤を用い,JWPA規格第2号に準じて行った。得られた結果の概要は次のとおりである。1)TCP-Na系薬剤に代わり得る性能を持つ多くの低毒性の薬剤が確認された。しかしそれらの薬剤の中には,特定の供試菌に効力を持たないものがあり,今後は相互の欠点を補い合う数種の薬剤を配合することが不可欠である。2)この試験において,D=30以下と評価された薬剤は,実用に際しても優れた効力を発揮すると考えられる。3)最近の薬剤は酸性溶液になるものが多く,薬液槽の鉄サビや溶液中の陽イオンによって起こる木材の変色・汚染の防止対策など,実用上さらに解決すべき多くの問題があると考えられる。
Study on Primary Frequency Regulation in S109E Combined Cycle Unit

The paper briefly analyses the logic associated with primary frequency regulation,such as,the speed control and load control of GE-9E gas steam combined cycle unit etc.And,it also introduces the dynamic response and problems of gas turbine and steam turbine affected by primary frequency regulation turbulence of original 9E unit.Therefore,it generates the control logic of primary frequency regulation for satisfying the power grid requirements by means of MARK V.The service and test result indicate that the primary frequency regulation can be realized in power grid for 9E gas steam combined cycle unit by this system.
Clinical pharmacology of dexrazoxane.

Dexrazoxane is a synthetic bisdiketopiperazine two-ringed compound which hydrolyzes to an EDTA analog. These rings undergo intracellular hydrolysis to form the single and double (ICRF-198) chelating forms of the compound by both enzymatic and non-enzymatic catalysis. These dexrazoxane metabolites are efficient at stripping the cations from the iron:anthracycline complex. The disruption of the complex prevents the oxidative damage from free radicals promoted by this anthracycline complex. Pharmacologic studies of single agent dexrazoxane (originally studied as an antineoplastic agent) demonstrates an alpha half-life of approximately 30 minutes and a beta half-life of 2 to 4 hours. When given in combination with anthracyclines (e.g. doxorubicin or epirubicin) the pharmacokinetics of dexrazoxane are unchanged. Additional studies of anthracycline metabolism when given in combination with dexrazoxane, both in single arm and randomized cross-over studies, have generally shown no change in anthracycline metabolism, including pharmacokinetic parameters of alpha, beta, and gamma half-lives, area-under-the-curve, or clearance. There is no pharmacokinetic interaction of dexrazoxane on anthracycline metabolism and, therefore, pharmacokinetics cannot account for the cardioprotective effects described for dexrazoxane.
Concise history of ballistic limit equations for multi-wall spacecraft shielding

Abstract All earth-orbiting spacecraft are susceptible to impacts by orbital debris particles, which can occur at extremely high speeds and can damage flight- and mission-critical systems. The traditional damage mitigating shield design for this threat consists of a “bumper” that is placed at a relatively small distance away from the main “inner wall” of the spacecraft. The performance of a hypervelocity impact shield is typically characterized by its ballistic limit equation, which is typically drawn as a line of demarcation between regions of rear-wall perforation and no perforation; when graphically represented, it is often referred to as a ballistic limit curve. Once developed, these equations and curves can be used to optimize the design of spacecraft wall parameters so that the resulting shields can withstand a wide variety of high-speed impacts by orbital debris. This paper presents some comments and observations on the development of the three-part ballistic limit equation used to predict the response of dual-wall structural systems under hypervelocity projectile impact. The paper concludes with some insights into the limitations of NASA’s current MMOD risk analysis code, and offers several suggestions regarding how it could be modified so that, for example, it could be used as an integral part of a probabilistic risk assessment exercise.
“We've Got to Keep Meeting Like This”: A Pilot Study Comparing Academic Performance in Shifting-Membership Cooperative Groups Versus Stable-Membership Cooperative Groups in an Introductory-Level Lab

ABSTRACTThis study examined possible ways to increase student engagement in small sections of a large, introductory-level, required university course. Research shows that cooperative group learning boosts achievement through fostering better interpersonal relationships between students. Cooperative group learning is an evidence-based instructional practice engaging students in active learning. The present study investigated whether cooperative groups with sustained-membership functioned more effectively for boosting performance than shifting-membership cooperative groups. Findings indicated that the amount of class time spent in groups influenced the impact of shifting or sustained-membership. A significant difference in performance was found for sustained-group students when group activities were used the majority of the time during recitation.
The Achievement of a 3-Month Complete Cytogenetic Response (3-mo CCyR) to Second Generation (2nd) Tyrosine Kinase Inhibitors (TKI) Post Imatinib Failure Is the Only Predictive Factor for Event-Free (EFS) and Overall Survival (OS)

Abstract Abstract 2289 2nd TKIs such as dasatinib and nilotinib have shown significant activity post imatinib failure, with high rates of hematologic and cytogenetic responses. Achieving early cytogenetic response is a known major determinant of outcome in patients (pts) treated with imatinib. In a previous report from our institution, we reported that the achievement of a previous cytogenetic response to imatinib therapy is a major predictive factor in pts receiving a 2nd TKI. The aim of our study was to assess the impact of a 3-mo CCyR on EFS and OS of pts treated with 2nd TKI post imatinib failure. 123 pts with chronic phase (CP) CML after imatinib failure were treated with dasatinib (n=78) or nilotinib (n=45). Median age was 56 years (range, 21–83). Median duration of CP (CML diagnosis to start of second generation TKI) was 67 months (range, 2–268). Their best response to imatinib was complete hematologic response (CHR) only in 24%, and cytogenetic response in 63% (28% complete, 17% partial, 18% minor). The CHR rates were 87% and 84% in pts treated with dasatinib and nilotinib, respectively (p=0.75). The major cytogenetic response rates were 64% and 62% (p=0.85), and the complete cytogenetic response rates were 60% and 56% (p=0.70). The rates of cytogenetic response at 3-, 6- and 12-mo were 59%, 63% and 69% (p=0.39) and 60%, 55% and 51% (p= 0.7) in pts treated with dasatinib and nilotinib, respectively, and the rates of CCyR at these same time-points were 32%, 41% and 48% (p= 0.13) and 36%, 36% and 35% (p= 0.99), respectively. The 3-year EFS and OS rates were 53% and 84%, respectively. Factors associated with poor EFS in the univariate were older age (> 55 years), lack of any cytogenetic response to previous imatinib therapy, more than ≥90% Philadelphia-positive metaphases (Ph) at the start of 2nd TKI therapy, and lack of a 3-mo CCyR to 2nd TKI therapy. In a multivariate analysis, the lack of a 3-mo CCyR to 2nd TKI therapy (HR= 4.5; p 55 years), increasing marrow blasts, lack of any cytogenetic response to previous imatinib therapy, and lack of a 3-mo CCyR to 2nd TKI therapy. In a multivariate analysis, only a lack of a 3-mo CCyR to 2nd TKI therapy (HR=5.4; p = 0.03) was independently associated with a lower probability of survival; the 3-year OS rates were 98% and 79% for pts with and without 3-mo CCyR, respectively. Therefore we analyzed factors that were associated with the 3-mo achievement of a CCyR. In the univariate analysis, high hemoglobin level, previous cytogenetic response to imatinib therapy, and ≤90% Ph, and increasing marrow blast% were associated with the achievement of a CCyR at 3 months of therapy with 2nd TKI. In the subsequent multivariate analysis for response, Ph% >90 and Hgb 90%) and anemia (Hgb Disclosures: Jabbour: BMS: Honoraria; Novartis: Honoraria. Cortes: Novartis: Research Funding; BMS: Consultancy; Pfizer: Consultancy, Research Funding.
Patient‐reported health status during pediatric cancer treatment

Background Changes in patient function and factors affecting pediatric patients with cancer during treatment are largely unknown. The purpose of this study was to measure patient-reported outcomes (PROs) in children during the initial 6 months of therapy to characterize function and explore factors associated with function including type of cancer, intensity of therapy, age, and gender. Procedure We conducted a prospective cohort study of children aged 5–21 newly diagnosed with cancer. PROs were obtained twice monthly over the first 6 months of treatment. The Patient-Reported Outcome Measurement Information System (PROMIS) was used to measure patient mobility, fatigue, pain interference, peer relationships, anxiety, and depressive symptoms. A generalized linear mixed model was used to analyze changes by domain over time. Results Forty patients completed the study with a mean age of 11.7 years (standard deviation [SD] 4.7), 60% had leukemia/lymphoma. All patients report improved pain over time (P = 0.008). Patients with central nervous system (CNS)/solid tumor report better mobility (P < 0.001), less fatigue (P < 0.001), less pain (P < 0.001), less anxiety (P < 0.001), fewer depressive symptoms (P < 0.001), and better peer relationships (P = 0.0036). Younger patients report worse mobility (P = 0.017), more fatigue (P = 0.032), more pain (P < 0.001), more anxiety (P = 0.017), and more depressive symptoms (P = 0.005). Conclusions Pain improved for all patients over the first 6 months of cancer treatment. Age and tumor type also affected patient-reported function for all domains. Understanding the burden of cancer treatment is critical to refine supportive care interventions to minimize the burden of pediatric cancer treatment.
Pedicled Vascularized Clavicular Graft for Anterior Cervical Arthrodesis: Cadaveric Feasibility Study, Technique Description, and Case Report.

Cadaveric feasibility study. To assess the anatomic and technical feasibility of rotating a clavicular segment on a sternocleidomastoid muscle (SCM) pedicle into the ventral cervical spine using a cadaveric model and to provide the first clinical case description of performing this procedure. Reconstruction of the anterior cervical spine in patients with a high risk of pseudoarthrosis may require the use of a vascularized bone graft (VBG). A vascularized clavicular graft rotated on an SCM pedicle would afford all the benefits of a VBG without the added morbidity of free-tissue transfer; however, this technique has not been described. A multidisciplinary team hypothesized that it would be anatomically and technically feasible to rotate a pedicled clavicular bone graft from the bottom of C2 to the top of T2 via an anterior approach. Five cadavers underwent bilateral anterior neck dissections for a total of 10 clavicular graft assessments. A case report describes the use of a clavicular VBG in a patient with a 3-level corpectomy defect and a history of failed fusion. Ten clavicles were rotated on an SCM pedicle. The grafts were either harvested as an entire segment or as the superior two-thirds of clavicle, leaving the inferior one-third in situ with pectoralis attachments intact. All grafts reached from the bottom of C2 to the top of T2. When the entire length of exposed clavicle was mobilized, it could cover 5–6 levels. The case report highlights technical challenges of this procedure in a living patient and provides clinical context for its potential utility in reconstruction of the ventral cervical spine. This surgical technique is best suited for patients with long-segment cervical defects and an increased risk of pseudarthrosis. Further clinical experience with this technique is required before definitive conclusions can be made. Level of Evidence: 5
Intraocular lens power calculations in eyes with previous hyperopic laser in situ keratomileusis or photorefractive keratectomy.

Purpose To evaluate the accuracy of 7 intraocular lens (IOL) calculation formulas in patients with previous hyperopic laser in situ keratomileusis (LASIK) or excimer laser photorefractive keratectomy (PRK). Design Retrospective case series. Setting Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, and private practice, Mesa, Arizona, USA. Methods The 7 formulas evaluated were the adjusted Atlas 0-3, Masket, Modified Masket, Haigis-L, Shammas-PL, Barrett True-K, and Barrett True-K No-History. The Masket and Modified Masket were calculated using the single-K version of Holladay 1 and Hoffer Q formulas; the adjusted Atlas 0-3 was calculated using the double-K version of Holladay 1 and Hoffer Q. The IOL power predicted by each formula was calculated by targeting the postoperative manifest refraction. The IOL prediction error was obtained by subtracting the predicted IOL power from the implanted IOL power. The mean IOL prediction error, median absolute refractive prediction error, and percentages of eyes within ±0.50 diopter (D) and ±1.00 D of the predicted refraction were calculated. Results Twenty-one eyes of 21 patients were evaluated. There were no significant differences in the median absolute refractive prediction error or percentages of eyes within ±0.50 D or ±1.00 D of the predicted refraction between formulas or methods. The IOL mean prediction errors were comparable between the Holladay 1 and Hoffer Q calculations for all formulas except for a greater error for the double-K version of the Hoffer Q of the adjusted Atlas 0-3. Conclusion In eyes that had hyperopic LASIK or PRK, there were no significant differences in the accuracy between the 7 IOL calculation formulas.
Survival following Y90 radioembolization for neuroendocrine tumor liver metastases: A retrospective, single-center analysis.

e15166 Background: Y90 radioembolization has become an increasingly common palliative measure for patients with unresectable metastatic neuroendocrine tumors (NETs) in the liver. The amount by whic...
The Academic Conference as a Chilly Climate for Women: Effects of Gender Representation on Experiences of Sexism, Coping Responses, and Career Intentions

Across many disciplines, women are underrepresented in faculty positions relative to men. The present research focuses on the academic conference as a setting because it is a gateway to an academic career and a context in which women might experience sexism. We surveyed 329 presenters (63% women) from three U.S. national academic conferences, which differed in women-to-men ratios, about their perceptions of the conference climate, their coping tactics (e.g., gender performance, silence, or voice), and their intentions to exit the conference or academia. The greater the representation of women at the conference relative to men, the less likely were women to perceive sexism and to feel they had to behave in a masculine manner in that setting. In contrast, women who perceived the conference as sexist and felt silenced also expressed increased intentions to exit from academic careers. Men’s perceptions of sexism predicted increased intentions to exit from that particular conference, but not from academia. Because conferences signal the norms of a discipline, it is important to explore their climates as they relate to gender. Perhaps especially for new and aspiring female academics, they may signal devalued status and lack of fit and as such play an inadvertent role in the “leaky pipeline.” We discuss strategies that conference organizers could implement to mitigate sexist climates, including broader inclusion of women in speaking and leadership roles and explicit attention to cues that women belong.
Ethnography for a new global political economy? Marcus (1995) revisited, through the lens of Tsing and Nash:

In 1995 George Marcus wrote on the ‘emergence of multi-sited ethnography’, contrasting ethnography in the world and ethnography of the world. He seemed to anticipate that with increasing globalizat...
Discharge home health services referral and 30-day all-cause readmission in older adults with heart failure.

Author(s): Arundel, Cherinne; Sheriff, Helen; Bearden, Donna M; Morgan, Charity J; Heidenreich, Paul A; Fonarow, Gregg C; Butler, Javed; Allman, Richard M; Ahmed, Ali | Abstract: IntroductionHeart failure (HF) is the leading cause of hospital readmission. Medicare home health services provide intermittent skilled nursing care to homebound Medicare beneficiaries. We examined whether discharge home health referral is associated with a lower risk of 30-day all-cause readmission in HF.Material and methodsOf the 8049 Medicare beneficiaries hospitalized for acute HF and discharged alive from 106 Alabama hospitals, 6406 (76%) patients were not admitted from nursing homes and were discharged home without discharge hospice referrals. Of these, 1369 (21%) received a discharge home health referral. Using propensity scores for home health referral, we assembled a matched cohort of 1253 pairs of patients receiving and not receiving home health referrals, balanced on 33 baseline characteristics.ResultsThe 2506 matched patients had a mean age of 78 years, 61% were women, and 27% were African American. Thirty-day all-cause readmission occurred in 28% and 19% of matched patients receiving and not receiving home health referrals, respectively (hazard ratio (HR) = 1.52; 95% confidence interval (CI): 1.29-1.80; p l 0.001). Home health referral was also associated with a higher risk of 30-day all-cause mortality (HR = 2.32; 95% CI: 1.58-3.41; p l 0.001) but not with 30-day HF readmission (HR = 1.28; 95% CI: 0.99-1.64; p = 0.056). HRs (95% CIs) for 1-year all-cause readmission, all-cause mortality, and HF readmission are 1.24 (1.13-1.36; p l 0.001), 1.37 (1.20-1.57; p l 0.001) and 1.09 (0.95-1.24; p = 0.216), respectively.ConclusionsHospitalized HF patients who received discharge home health services referral had a higher risk of 30-day and 1-year all-cause readmission and all-cause mortality, but not of HF readmission.
Law enforcement practices in the first two states in U.S. to legalize recreational marijuana

Abstract Background There is a lack of research regarding law enforcement practices where recreational marijuana sales are legal. Given that legalization of recreational marijuana is expanding, lessons learned from areas with existing legalization can help inform future practices. This pilot study is an evaluation of enforcement of marijuana laws in the first two states in the U.S. to legalize sales of recreational marijuana, Colorado and Washington, several years post legalization. Methods We surveyed a random sample of local law enforcement agencies in the two states (25 agencies per state). We also attempted to survey the state-level marijuana enforcement agency but only Washington responded. Surveys focused on youth marijuana use, youth access to marijuana, and impaired driving but included other topics. Chi-square tests assessed differences between states (p Results All local agencies reported underage use was somewhat or very common in their jurisdictions. Thirty percent of local agencies conducted enforcement targeting underage use/possession. Twenty percent of agencies overall conducted underage compliance checks at licensed stores, with more agencies conducting checks in Colorado (32%) than Washington (8%; p = .03). Most agencies in both states reported marijuana-impaired driving was somewhat or very common in their jurisdictions. One local agency in each state specifically targeted marijuana-impaired driving. The state-level agency in Washington reported that their agency is the one primarily responsible for enforcing marijuana retail laws and they conducted routine underage compliance checks at all licensed marijuana stores three times per year. Conclusion Our findings indicate that marijuana enforcement can be improved regarding sales/provision to underage youth and impaired driving in these states, particularly given that underage use and impaired driving are perceived to be common. Larger studies with additional jurisdictions and types of agencies (e.g., highway patrol) are warranted.
Testing Measurement Invariance of the Moral Foundations Questionnaire Across 27 Countries.

It has become clear that there are multiple “moralities”: diverse bases that guide people’s judgments of right and wrong. The widely known Moral Foundations Theory stipulates that there are at leas...
The impact of the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) in reducing outcome disparities based on race.

6555 Background: The NBCCEDP, created in 1990, provides breast and cervical cancer screening and diagnostic services to low-income and uninsured women. The program’s effectiveness in reducing racia...
Enabling Identification and Behavioral Sensing in Homes using Radio Reflections

Understanding users' behavior at home is central to behavioral research. For example, social researchers are interested in studying domestic abuse, and healthcare professionals are interested in caregiver-patient interaction. Today, such studies rely on diaries and questionnaires, which are subjective, erroneous, and hard to sustain in longitudinal studies. We introduce Marko, a system that automatically collects behavior-related data, without asking people to write diaries or wear sensors. Marko transmits a low power wireless signal and analyses its reflections from the environment. It maps those reflections to how users interact with the environment (e.g., access to medication cabinet) and with each other (e.g., watch TV together). It provides novel algorithms for identifying who-does-what, and bootstrapping the system in new homes without asking users for new annotations. We evaluate Marko with a one-month deployment in six homes, and demonstrate its value for studying couple relationships and caregiver-patient interaction.
Adaptively truncated Hilbert space based impurity solver for dynamical mean-field theory

We present an impurity solver based on adaptively truncated Hilbert spaces. The solver is particularly suitable for dynamical mean-field theory in circumstances where quantum Monte Carlo approaches are ineffective. It exploits the sparsity structure of quantum impurity models, in which the interactions couple only a small subset of the degrees of freedom. We further introduce an adaptive truncation of the particle or hole excited spaces, which enables computations of Green functions with an accuracy needed to avoid unphysical (sign change of imaginary part) self-energies. The method is benchmarked on the one-dimensional Hubbard model.
PD-1 Blockade in Advanced Adrenocortical Carcinoma

PURPOSEAdrenocortical carcinomas (ACC) are rare and aggressive malignancies with limited treatment options. This study was undertaken to evaluate the immunogenicity of ACC.PATIENTS AND METHODSPatie...
Fichte’s Life and Philosophical Trajectory

J. G. Fichte presented his transcendental idealism in many different ways, but despite radical changes in terms, style, and method throughout his philosophical development, each version retained the essence of the one and only Wissenschaftslehre. His philosophical task was always to relate life or human consciousness (that is, sensible experience at the empirical standpoint) to its supersensible ground (that is, pure consciousness at the transcendental standpoint). Although life and philosophy are opposites, life presumes concepts and principles that can only be justified by philosophy at the transcendental standpoint, and philosophy presupposes feelings, intuitions, and beliefs that can only be discovered at the empirical standpoint.
CFD Model of PM Sedimentation and Resuspension in Urban Water Clarification

AbstractUnit operations (UO) for urban water clarification are commonly implemented for management of particulate matter (PM), PM-associated chemicals, and microbial species, primarily through sedi...
Molecular Breast Cancer Imaging in the Era of Precision Medicine

OBJECTIVE. Precision medicine in oncology aims to individualize the patient's treatment and management regimen according to the accurate assessment of diagnosis, risk of recurrence, or progression. In this review, we will discuss the evolving role of molecular imaging (breast-specific gamma imaging and positron emission mammography) toward precision medicine in patients with breast cancer. CONCLUSION. Incorporating molecular imaging for breast cancer will lead to precision medicine, which holds promise to facilitate appropriate personalized treatment in patients with breast cancer.
Endosomal recycling reconciles the Alzheimer's disease paradox.

A hub-and-spoke model with endosomal recycling as the hub can reconcile the pathogenic contribution of amyloid precursor protein to Alzheimer’s disease.
Gravitomagnetic Dipole Moment of Gravitational Unit Cells

It is proposed that gravitational meta-atom unit cells with gravitomagnetic moments could exhibit gravitomagnetic permeability, analogous to the magnetic permeability of materials comprised of atoms with magnetic moments. Recently, a gravitoelectromagnetic (GEM) framework was proposed to explore the possibility of a Veselago-inspired approach to gravitational metamaterials. The prospect of gravitational metamaterials motivates the consideration of candidate gravitational unit cells or gravitational meta-atoms. Although mass serves as a monopole source of a gravitoelectric field similar to positive charge, negative mass would be needed to create a gravitational analog of an electric dipole. However, moving mass is analogous to electric current, and can lead to a gravitomagnetic dipole moment analogous to magnetic dipole moments of magnetic materials and atoms. In this paper, GEM field approximations to general relativity are used to find the gravitomagnetic dipole moment of different rotating systems, ranging in scale from meters to astronomical size.
A Market for Tax Compliance

It is becoming increasingly clear that, due to political realities and budgetary constraints, the IRS is going to have to attempt to enforce the tax laws by doing more with less. Current enforcement efforts have yielded a tax gap (i.e., the difference between the amount of taxes that should be paid and the amount that are collected) of roughly $450 billion annually. Faced with this task, one of the steps that the IRS has recently taken is to try to improve the quality in services performed by paid tax preparers, a group that historically has been subject to little IRS regulation or monitoring but that continues to play an increasingly important role in the tax system.Although the IRS’s recent efforts to better regulate paid preparers is a good step in improving the quality of tax services, its current structure as a mandatory regulatory regime causes it to miss a number of compliance oriented advantages that could be achieved through a voluntary system of tax preparer regulation in which tax preparers could choose to seek certifications indicating whether they had a positive track record of compliance.This paper explores in detail for the first time in the literature how preparer regulation could achieve significantly more compliance gains if it were structured as a voluntary system designed to create a market that rewards tax compliance. Under a voluntary compliance certification regime with appropriately structured participation incentives aimed both at paid preparers and their clients, paid tax preparers are not simply mandated to achieve a minimal level of competence; they are instead provided with competitive advantages in the marketplace for achieving higher levels of compliance than preparers who have poor compliance track records. As a result, preparers are more likely to choose to pursue higher levels of compliance in order to obtain and maintain a certification. In addition, many taxpayers are more likely to seek out compliance certified preparers because of the benefits associated with relying on advice and filing tax returns prepared by compliance certified preparers. This piece seeks to lay the framework for how such a voluntary compliance certification program would work and to discuss the benefits of such a system that are currently not being realized through the IRS’s current regulation of paid preparers.
Transcriptional reprogramming by oxidative stress occurs within a predefined chromatin accessibility landscape.

Abstract Reactive oxygen species (ROS) are important signaling molecules in many physiological processes, yet excess ROS leads to cell damage and can lead to pathology. Accordingly, cells need to maintain tight regulation of ROS levels, and ROS-responsive transcriptional reprogramming is central to this process. Although it has long been recognized that oxidative stress leads to rapid, significant changes in gene expression, the impact of oxidative stress on the underlying chromatin accessibility landscape remained unclear. Here, we asked whether ROS-responsive transcriptional reprogramming is accompanied by reprogramming of the chromatin environment in MCF7 human breast cancer cells. Using a time-course exposure to multiple inducers of oxidative stress, we determined that the widespread ROS-responsive changes in gene expression induced by ROS occur with minimal changes to the chromatin environment. While we did observe changes in chromatin accessibility, these changes were: (1) far less numerous than gene expression changes after oxidative stress, and (2) occur within pre-existing regions of accessible chromatin. Transcription factor (TF) footprinting analysis of our ATAC-seq experiments identified 5 TFs or TF families with evidence for ROS-responsive changes in DNA binding: NRF2, AP-1, p53, NFY, and SP/KLF. Importantly, several of these (AP-1, NF–Y, and SP/KLF factors) have not been previously implicated as widespread regulators in the response to ROS. In summary, we have characterized genome-wide changes in gene expression and chromatin accessibility in response to ROS treatment of MCF7 cells, and we have found that regulation of the large-scale transcriptional response to excess ROS is primarily constrained by the cell's pre-existing chromatin landscape.
Review of "Bans, Walls, Raids, Sanctuary: Understanding U.S. Immigration for the Twenty-First Century" by A. Naomi Paik (University of California Press)

A. Naomi Paik’s Bans, Walls, Raids, Sanctuary responds to a trio of executive orders on immigration policy issued in the early days of Donald Trump’s presidency. Those orders sought to make good on campaign promises to further restrict immigration by banning citizens from Muslim-majority countries, allocating funds to expand a border wall between the US and Mexico, and ramping up home and workplace deportation raids by Immigration and Customs Enforcement (ICE). Paik delineates how these legal barriers came to be by locating them in relation to the nation’s formative immigration policies, backlash to the liberation movements of the 1960s and 1970s, and the global repercussions of neoliberalism. Highlighting the work of Indigenous activists, Paik eventually calls not only for the dramatic restructuring of the nation’s immigration system but also for the creation of a more just society based on relationships that reject the politics of inclusion and exclusion.
Strategies of Sequence Analysis of Regulatory Subunit of Bovine Cardiac Muscle cAMP-Dependent Protein Kinase Type II

The regulatory subunit of bovine cardiac muscle cAMP- dependent protein kinase has a molecular weight of 45,000 and is composed of a single chain with blocked amino terminus and 400 amino acid residues including 9 Met, 6 CySH and one Trp.
In-Situ Mechanical Property Evaluation of Dielectric Ceramics in Multilayer Capacitors

The Young's modulus, hardness, and fracture toughness of barium titanate dielectric ceramics in three commercially available multilayer capacitors (MLCs) were measured in-situ using indentation and a mechanical properties microprobe. The three MLCs were equivalent in size (0805), capacitance (0.1 uF) and dielectric type (X7R). The Young's modulus and hardness of the dielectric ceramics in the three MLCs were similar, while there were statistically significant differences in their fracture toughnesses. The results provide insight into the assessment of MLC mechanical reliability, and show that equivalent electrical MLC rating is not necessarily a guarantee that the dielectric ceramics in them will exhibit equivalent mechanical performance.
Progressive masks : letters of Oliver Wendell Holmes, Jr., and Franklin Ford

These remarkable letters reveal Holmes to be patient, sympathetic, even indulgent of theories that, by his own admission, he did not really understand. The y bring further notice to financial analyst Franklin Ford, who was a close associate of John Dewey.
Effect of H2 addition on surface reactions during CF4/H2 plasma etching of silicon and silicon dioxide films

In situ multiple internal reflection Fourier transform infrared spectroscopy and spectroscopic ellipsometry are used to study the surfaces of Si and SiO2 films during etching with CF4/H2 plasmas. At sufficiently low H2 concentration, a thin fluorocarbon film forms on both Si and SiO2 surfaces during etching, but Si and SiO2 removal continues despite the existence of such a layer. The structure of this film depends on the H2 concentration in the feed gas. Above a critical H2 concentration, the fluorocarbon film becomes more crosslinked, fluorine deficient, and amorphous carbonlike. Formation and subsequent growth of this fluorinated amorphous carbon (a-C:F) film stops etching of both Si and SiO2. In the absence of energetic ion bombardment, the critical concentration at which etching is arrested and a-C:F growth begins is the same for both Si and SiO2 films indicating that whether this film forms or not is determined by the fluxes of reactive species arriving at the surface from the gas phase rather than b...
The Evolvement of Automobile Steering System Based on TRIZ

Products and techniques pass through a process of birth, growth, maturity, death and quit the stage like biological evolution process. The developments of products and techniques conform to some evolvement rules. If people know and hold these rules, they can design new kind of products and forecast the develop trends of the products. Thereby, enterprises can grasp the future technique directions of products, and make product and technique innovation. Below, based on TRIZ theory, the mechanism evolvement, the function evolvement and the appearance evolvement of automobile steering system had been analyzed and put forward some new ideas about future automobile steering system.
Vermiculite Surface Morphology

A study of the surface morphology of vermiculites from several different sources by the electron microscope has indicated that, unlike the smooth surfaces of micas, the vermiculite surfaces show micromorphological structural variations such as small humps, prominent crystallographic steps on the basal cleavage planes, marginal rolling of the layers and layer buckling. The production of layer buckling may result from the inhomogeneity of interlayer population caused by the introduction of hydrated cations replacing potassium during weathering. The (110) steps on the surface of the cleavage can be observed and these are visualized as nuclei for weathering in addition to the particle edges.
Optimization of the electrodeposition of raney nickel on titanium substrate

The electrodeposition of Raney nickel onto a titanium grid substrate was investigated. Optimization of current density and charge density was performed via a factorial design experimental method to maximize the percentage of Raney nickel powder deposited on the grid. A scale-up of the deposition process was performed to demonstrate the feasibility of the procedure using larger substrates. Reproducible electrodes were obtained which can find applications in fuel cells as well as electrolytic hydrogen generators.
The resonant hot electron transfer amplifier: A continuum resonance device

Abstract The resonant states in the continuum above a multi-quantum well structure produce strong variations in the transmission coefficient as a function of injected electron energy. A device design which exploits these resonant effects is proposed. The Resonant Hot Electron Transfer Amplifier (RHETA) is a three-terminal device in which the transfer of hot electrons across the base is modulated by shifting the injected electron energy relative to the resonant states.
INVERSIONS DISRUPTING THE FACTOR VIII GENE. ASSOCIATION WITH INHIBITOR DEVELOPMENT 171

Haemophilia A is one of the most common X-linked hereditary coagulation disorders with a freguency of ≈ 1 in 5,000 male births in all ethnic groups. A large number of different molecular defects have been described in patients with haemophilia A. The most common mutation in patients with the severe form is a partial inversion of factor VIII mediated by a 9.5 Kb sequence, present in the large intron 22 of factor VIII and twice more about 400 Kb telomeric to it. Different types of the partial inversion account for 43% of the molecular defects in those patients. A higher frequency for inhibitors development seems to be associated with this type of defect.