cssi/SciSciGPT-SciSciNet huggingface dataset:
Voltage-gated and calcium-gated calcium release during depolarization of skeletal muscle fibers.

The role of elevated intracellular calcium concentration ([Ca2+]) in activating calcium release from the sarcoplasmic reticulum (SR) was studied in skeletal muscle fibers microinjected with strong calcium buffers. After the injection of 3.8 +/- 0.5 mM (mean +/- S.E. of mean, n = 16) BAPTA (1,2-bis[o-aminophenoxy]ethane- N,N,N',N'-tetraacetic acid) or 2.2-2.8 mM fura-2 the normal increase in [Ca2+] during a depolarizing pulse was virtually eliminated. Even though calcium was released from the SR the kinetics of this release were markedly altered: the extensive buffering selectively eliminated the early peak component of SR calcium release with no effect on the maintained steady level. Microinjections of similar volumes but with low concentrations of fura-2 had no significant effect on the release waveform. The calcium released by voltage-dependent activation during depolarization may thus be involved in activating further calcium release, that is, in a calcium-induced calcium release mechanism.
Psychophysiological correlates of narcissistic traits in women during active coping

Two dimensions of narcissism were related to psychophysiological responses to stress in 50 young women. Cardiovascular, electrodermal, task performance, and stress appraisal measures were recorded during rest, mental arithmetic, and a computerized Thematic Apperception Test (Murray, 1943). The Egocentricity and Alienation scales of the Bell Object Relations and Reality Testing Inventory (Bell, 1995) served as measures of overt/inflated and covert/deflated narcissism. Egocentricity correlated consistently with heightened preejection period reactivity, whereas Alienation correlated consistently with diminished electrodermal reactivity (all p < .05). Multivariate analyses supported specific relationships between Egocentricity and preejection period hyperreactivity, and between Alienation and electrodermal hyporeactivity. These results have implications for narcissism, cardiovascular disease risk, and a variety of psychiatric disorders.
Gene-Diet Interactions on Colorectal Cancer Risk.

There has been increasing interest lately in understanding how natural dietary antioxidants affect chemoprevention, and recently, there has been a merging of information about antioxidants, endogenous and exogenous reactive oxygen and nitrogen species (RONS), and inflammation. RONS normally serve the cells as second messengers to regulate many of the intracellular signaling cascades that govern multiple cellular activities. However, when the amount of RONS exceeds the cell’s ability to metabolize/eliminate them, the cell becomes stressed and acquires genetic and epigenetic aberrations and dysregulated intracellular signaling cascades. In addition, there has been a better understanding of the role of tissue inflammation in the carcinogenesis process. Herein we integrate these fields to explain where RONS arise and how natural dietary antioxidants are principally working through refurbishing pathways that use RONS as second messengers.
Vancomycin plasma concentrations in cardiac surgery with the use of profound hypothermic circulatory arrest.

Objective:Thisstudywasundertakentocomparetheeffectofdeephypothermiccirculatoryarrest,comparedwithmoderatehypothermia,on the plasma concentrations and pharmacokinetic profile of vancomycin, administered as prophylaxis, in patients undergoing cardiac surgery with cardiopulmonary bypass. Methods: Two groups of adult cardiac surgery patients were prospectively studied. One group consisted of 12 patients undergoing valvular surgery with moderate hypothermia, and another group was of 12 patients undergoing surgery with the use of profound hypothermic circulatoryarrest. Vancomycin was administeredbefore skin incision, and plasma levels were measured at regular intervals for 24 h. Results: The plasma concentrations of vancomycin showed a similar pattern in both groups. The pharmacokinetic profile showed a threecompartment model in both groups. Conclusion: The dosing of vancomycin, if used as antibiotic prophylaxis, does not need to be adjusted in cardiac surgery patients when undergoing profound hypothermic circulatory arrest, since the plasma concentrations and pharmacokinetic profile are similar to patients with moderate hypothermia. The pharmacokinetic profile, consisting of three compartments, was not changed by the differences in temperature. # 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
A Breath Biofeedback Computer Game for Children With Cystic Fibrosis

The authors sought to develop and test a breath-controlled video game using a digital spirometer that, by providing visual breath biofeedback, could promote awareness of breathing techniques in children with cystic fibrosis (CF). To assess improvement in game performance during hospitalizations for CF exacerbations, the authors conducted a trial on 10 inpatients. Subjects had at least five 15-minute exposures to a breath biofeedback game that challenged them to track a moving target using their breath. Subjects reacted positively to the breath tracking challenge. Repeated-measures analysis of variance of a tracking fidelity statistic showed improvement in eye—breath coordination over 5 sessions ( P = .026). It was concluded that an electronic breath game is safe and can improve breath awareness among children with CF. This technology could also contribute to awareness of respiratory symptoms and foster social ties among CF patients.
Recovering Landscape: Essays in Contemporary Landscape Architecture Edited by James Corner New York, Princeton Architectural Press (1999) ISBN 1-56898-179-1

Abstract In A Landscape of Events,1 the French architect, planner and philosopher Paul Virilio describes the ‘miniaturization of destructive power’ that now allows individuals rather than vast armies to deconstruct with maximum impact. The world now looks no further than the horrific events of 11 September, 2001 sadly to confirm Virilio's theory. The world also knows too well that the information, media and international televized coverage following such tragedies are ‘communications weapons,’ giving individuals, rather than governments, political value to manipulate international public opinion. Virilio's ‘miniaturization of destructive power’ is the result of hard physical evidence and the verbal terrain created while exposing it.
Prestin and the cochlear amplifier

In non-mammalian, hair cell-bearing sense organs amplification is associated with mechano-electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.
Comparison of local-to regional-scale estimates of ground-water recharge in Minnesota, USA

Summary Regional ground-water recharge estimates for Minnesota were compared to estimates made on the basis of four local- and basin-scale methods. Three local-scale methods (unsaturated-zone water balance, water-table fluctuations (WTF) using three approaches, and age dating of ground water) yielded point estimates of recharge that represent spatial scales from about 1 to about 1000 m2. A fourth method (RORA, a basin-scale analysis of streamflow records using a recession-curve-displacement technique) yielded recharge estimates at a scale of 10–1000s of km2. The RORA basin-scale recharge estimates were regionalized to estimate recharge for the entire State of Minnesota on the basis of a regional regression recharge (RRR) model that also incorporated soil and climate data. Recharge rates estimated by the RRR model compared favorably to the local and basin-scale recharge estimates. RRR estimates at study locations were about 41% less on average than the unsaturated-zone water-balance estimates, ranged from 44% greater to 12% less than estimates that were based on the three WTF approaches, were about 4% less than the age dating of ground-water estimates, and were about 5% greater than the RORA estimates. Of the methods used in this study, the WTF method is the simplest and easiest to apply. Recharge estimates made on the basis of the UZWB method were inconsistent with the results from the other methods. Recharge estimates using the RRR model could be a good source of input for regional ground-water flow models; RRR model results currently are being applied for this purpose in USGS studies elsewhere.
Infrastructure for automatic dynamic deployment of J2EE applications in distributed environments

Recent studies have shown the potential of using component frameworks for building flexible adaptable applications for deployment in distributed environments. However this approach is hindered by the complexity of deploying component-based applications, which usually involve a great deal of configuration of both the application components and system services they depend on. In this paper we propose an infrastructure for automatic dynamic deployment of J2EE applications, that specifically addresses the problems of (1) inter-component connectivity specification and its effects on component configuration and deployment; and (2) application component dependencies on application server services, their configuration and deployment. The proposed infrastructure provides simple yet expressive abstractions for potential application adaptation through dynamic deployment and undeployment of components. We report on our experience with implementing the infrastructure as a part of the JBoss J2EE application server and testing it on several sample J2EE applications.
Factors associated with intern noncompliance with the 2003 Accreditation Council for Graduate Medical Education’s 30-hour duty period requirement

In 2003 the Accreditation Council for Graduate Medical Education mandated work hour restrictions. Violations can results in a residency program being cited or placed on probation. Recurrent violations could results in loss of accreditation. We wanted to determine specific intern and workload factors associated with violation of a specific mandate, the 30-hour duty period requirement. Retrospective review of interns’ performance against the 30-hour duty period requirement during inpatient ward rotations at a pediatric residency program between June 24, 2008 and June 23, 2009. The analytical plan included both univariate and multivariable logistic regression analyses. Twenty of the 26 (77%) interns had 80 self-reported episodes of continuous work hours greater than 30 hours. In multivariable analysis, noncompliance was inversely associated with the number of prior inpatient rotations (odds ratio: 0.49, 95% confidence interval (0.38, 0.64) per rotation) but directly associated with the total number of patients (odds ratio: 1.30 (1.10, 1.53) per additional patient). The number of admissions on-call, number of admissions after midnight and number of discharges post-call were not significantly associated with noncompliance. The level of noncompliance also varied significantly between interns after accounting for intern experience and workload factors. Subject to limitations in statistical power, we were unable to identify specific intern characteristics, such as demographic variables or examination scores, which account for the variation in noncompliance between interns. Both intern and workload factors were associated with pediatric intern noncompliance with the 30-hour duty period requirement during inpatient ward rotations. Residency programs must develop information systems to understand the individual and experience factors associated with noncompliance and implement appropriate interventions to ensure compliance with the duty hour regulations.
Thomas Edison as a manager of R&D: the case of the alkaline storage battery, 1898-1915

From 1898 to 1915, Thomas Edison devoted the resources of his laboratory in the US to developing an alkaline storage battery. Initially, Edison intended that this battery would be used in electric automobiles, but technical problems prevented him from introducing his battery before this market disappeared. It is argued that in the course of this invention Edison modified his style and approach. In particular, Edison became less of a tinkerer and more of a research director supervising a team of college-trained chemists and engineers. As a research director, Edison motivated his experimenters by using informal management techniques and he insisted on keeping research closely connected to manufacturing. Most of all, his approach shifted from being divergent in which he tried many solutions, to being convergent, in which he directed experiments toward a highly specified goal. >
Delayed onset of autoimmune hemolytic anemia complicating cladribine therapy for Waldenström macroglobulinemia.

Therapeutic options for patients with Waldenstrom macroglobulinemia (WM) now include the purine nucleoside analogues, fludarabine and cladribine. Both these agents have been associated with the onset of severe life-threatening autoimmune hemolytic anemia (AIHA) in patients with chronic lymphocytic leukemia (CLL). In these reports, AIHA developed within 6 weeks of drug administration and was generally resistant to conventional therapy. AIHA following purine analogues has not been reported in other hematologic malignancies. We report here on 4 patients with WM who developed AIHA following cladribine therapy. Cladribine was administered as a 2-hour infusion at a dose of 0.12 mg/kg per day for 5 consecutive days, at 28-day intervals. The median number of cycles was four (range, 4 to 6). AIHA occurred at a median of 40 months (range, 24 to 60) from cladribine administration. Only 1 patient responded to oral steroids while the other 3 were resistant to multiple therapeutic interventions. Two patients, 1 in comp...
Decentralized cooperative search by networked UAVs in an uncertain environment

This paper addresses the problem of cooperative search in a given environment by a team of unmanned aerial vehicles (UAVs). We present a decentralized control model for cooperative search and develop a real-time approach for online cooperation among vehicles, which is based on treating the possible paths of other vehicles as "soft obstacles" to be avoided. Using the approach of "rivaling force" between vehicles to enhance cooperation, each UAV takes into account the possible actions of other UAVs such that the overall information about the environment is increased. The simulation results illustrate the effectiveness of the proposed strategy.
Constructing professional identity in art therapy through service-learning and practica

Professional identity is a term used to describe both the collective identity of a profession and an individual's own sense of the professional role. This article draws from the literature exploring professional identity with attention to the issues of developing professional identity in fields such as art therapy where lower wages, fewer jobs, and the frequent need to earn additional practice credentials exist. A qualitative research project was conducted during which students participated in service-learning in conjunction with an art therapy practicum assignment. Service-learning was introduced as a pedagogy to facilitate the identity construction of art therapy students, and was found to nurture aspects of professional identity described in the literature.
A Finite-dimensional Stabilized Variational Method for Unbounded Operators

Stabilization problems inevitably arise in the solution of inverse problems that are phrased in infinite-dimensional function spaces. The direct versions of these problems typically involve highly smoothing operators and consequently the inversion process is usually highly ill posed. This ill-posed problem can be viewed on a theoretical level (and often on a quite practical level) as evaluating an unbounded operator on some data space (an extension of the range of the direct operator). A typical case involves the solution of a linear inverse problem phrased as a Fredholm integral equation of the first kind
Limiting Infarct Size in ST-Segment Myocardial Infarction: The Holy Grail of Reperfusion Therapy.

Acute thrombotic occlusion of a coronary artery usually produces myocardial ischemia that can result in myocardial infarction if reperfusion is not restored. Reperfusion injury from reintroduction of blood and oxygen into the ischemic area at risk can result in additional myocyte cell death [(1,2)][
Multiple Anonymized Social Networks Alignment

Users nowadays are normally involved in multiple (usually more than two) online social networks simultaneously to enjoy more social network services. Some of the networks that users are involved in can share common structures either due to the analogous network construction purposes or because of the similar social network features. However, the social network datasets available in research are usually pre-anonymized and accounts of the shared users in different networks are mostly isolated without any known connections. In this paper, we want to identify such connections between the shared users' accounts in multiple social networks (i.e., the anchor links), which is formally defined as the M-NASA (Multiple Anonymized Social Networks Alignment) problem. M-NASA is very challenging to address due to (1) the lack of known anchor links to build models, (2) the studied networks are anonymized, where no users' personal profile or attribute information is available, and (3) the "transitivity law" and the "one-to-one property" based constraints on anchor links. To resolve these challenges, a novel two-phase network alignment framework UMA (Unsupervised Multi-network Alignment) is proposed in this paper. Extensive experiments conducted on multiple real-world partially aligned social networks demonstrate that UMA can perform very well in solving the M-NASA problem.
Robust and sparse bridge regression

It is known that when there are heavy-tailed errors or outliers in the response, the least squares methods may fail to produce a reliable estimator. In this paper, we proposed a generalized Huber criterion which is highly flexible and robust for large errors. We applied the new criterion to the bridge regression family, called robust and sparse bridge regression (RSBR). However, to get the RSBR solution requires solving a nonconvex minimization problem, which is a computational challenge. On the basis of recent advances in difference convex programming, coordinate descent algorithm and local linear approximation, we provide an efficient computational algorithm that attempts to solve this nonconvex problem. Numerical examples show the proposed RSBR algorithm performs well and suitable for large-scale problems.
Social Systems Structure, Job Design, and Growth Need Strength: A Test of a Congruency Model

An eight cell congruency framework for social system structure (mechanistic-organic), job design (simple-complex), and employee growth need strength (low-high) was used to predict employee satisfac...
Trajectory Tracking Control of Robotic Manipulator System Based on Iterative Learning Algorithm

An improved D-type learning law with time-varying exponential gain and initial state learning w as proposed and the certification of convergence for this learning law w as given for the planar 2-DOF manipulator w hich is an non-linear system. Simulation results show ed that the iterative learning control w as very effective for the planar 2-DOF manipulator system w hich ow ned property of repetitiveness. D-type learning law w ith time-varying exponential gain and initial state learning w as obtained w hich could eliminate the impact of the initial state migration on tracking performance and improve the convergence rates of the algorithm. What's more,the robustness of iterative learning control w as also improved.
Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.

Synapses express different forms of plasticity that contribute to different forms of memory, and both memory and plasticity can become labile after reactivation. We previously reported that a persistent form of nonassociative long-term facilitation (PNA-LTF) of the sensorimotor synapses in Aplysia californica, a cellular analog of long-term sensitization, became labile with short-term heterosynaptic reactivation and reversed when the reactivation was followed by incubation with the protein synthesis inhibitor rapamycin. Here we examined the reciprocal impact of different forms of short-term plasticity (reactivations) on a persistent form of associative long-term facilitation (PA-LTF), a cellular analog of classical conditioning, which was expressed at Aplysia sensorimotor synapses when a tetanic stimulation of the sensory neurons was paired with a brief application of serotonin on 2 consecutive days. The expression of short-term homosynaptic plasticity [post-tetanic potentiation or homosynaptic depression (HSD)], or short-term heterosynaptic plasticity [serotonin-induced facilitation or neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFa)-induced depression], at synapses expressing PA-LTF did not affect the maintenance of PA-LTF. The kinetics of HSD was attenuated at synapses expressing PA-LTF, which required activation of protein kinase C (PKC). Both PA-LTF and the attenuated kinetics of HSD were reversed by either a transient blockade of PKC activity or a homosynaptic, but not heterosynaptic, reactivation when paired with rapamycin. These results indicate that two different forms of persistent synaptic plasticity, PA-LTF and PNA-LTF, expressed at the same synapse become labile when reactivated by different stimuli. SIGNIFICANCE STATEMENT Activity-dependent changes in neural circuits mediate long-term memories. Some forms of long-term memories become labile and can be reversed with specific types of reactivations, but the mechanism is complex. At the cellular level, reactivations that induce a reversal of memory must evoke changes in neural circuits underlying the memory. What types of reactivations induce a labile state at neural connections that lead to reversal of different types of memory? We find that a critical neural connection in Aplysia, which is modified with different stimuli that mediate different types of memory, becomes labile with different types of reactivations. These results provide insights for developing strategies in alleviating maladaptive memories accompanying anxiety disorders.
Towards a typology of word-level causatives

The paper proposes that word-level causatives can be classified into two types, simplex causatives and complex causatives. Simplex causatives can be further classified into labile simplex causatives and non-labile simplex causatives, and complex causatives can be further classified into derivational, compounding, and inflectional complex causatives. It shows that it is possible for simplex causatives and some form of complex causatives to co-exist in a language. Moreover, the paper demonstrates that the existence of productive compounding/inflectional causatives tends to lead to the absence of a reasonable number of labile simplex causatives and that there is a functional basis for this. Finally, the paper shows that Chinese manifests a typological shift from the use of non-compounding word-level causatives to the use of productive compounding complex causatives.
Outcomes in patients undergoing cardiac catheterization and therapeutic hypothermia after cardiac arrest

Background: We aimed to elucidate the post-hospitalization outcomes in patients undergoing therapeutic hypothermia and cardiac catheterization after sudden cardiac arrest (SCA). Methods: A retrospective, tertiary-center study consisted of 173 consecutive patients who met inclusion criteria between
Computational algorithm to automate as-built schedule development using digital daily work reports

Abstract As-built schedules prepared during and after construction are valuable tools for State Highway Agencies (SHAs) to monitor construction progress, evaluate contractor's schedule performance, and defend against any potential disputes. However, previous studies indicate that current as-built schedule development methods are manual and rely on information scattered in various field diaries and meeting minutes. SHAs have started to collect field activity data in digital databases that can be used to automatically generate as-built schedules if proper computational algorithms are developed. This study develops computational algorithms and a prototype system to automatically generate and visualize project level and activity level as-built schedules during and after construction. The algorithm is validated using a real highway project data. The study is expected to significantly aid SHAs in making better use of field data, facilitate as-built schedule development, monitor construction progress with higher granularity, and utilize as-built schedule for productivity analysis.
Evaluation of the timing of adjuvant mitomycin C following nephroureterectomy for urothelial carcinoma of the upper urinary tract.

444Background: Results of randomized trials support a single dose of intravesical chemotherapy (IVC) following radical nephroureterectomy (RNU) for urothelial carcinoma. Our goal was to evaluate th...
Cell-free production of full-length ice nucleating protein InaZ

Unlike inorganic or other synthetic alternatives, ice nucleating proteins - INPs - remain the most efficient ice nuclei today. Their potential applications in cryo-preservation, biomedicine, food industry and in the modulation of climate are widespread. Nevertheless, due to multiple difficulties to express these proteins in full-length in necessary yields using cell-based recombinant methods, further applications are limited. As a result, our understanding of the structure and ice nucleation mechanism for this class of proteins is also incomplete. Using wheat-germ cell-free expression pipeline, we successfully expressed and purified full-length ice nucleating protein InaZ from Pseudomonas syringae, known as a model INP. High protein yield and solubility has been achieved using this cell-free platform, allowing us to confirm the heterogeneous nature of InaZ assembly using negative stain TEM. The cell-free produced InaZ protein was confirmed to be functional by conducting ice nucleation experiments inside a dynamic environmental scanning electron microscope (ESEM). We believe that the current platform will be suitable for expressing other INPs of interest and can be further employed for industrial and structural characterization needs as INP source.
Description of a New Species of Caecincola (Trematoda: Cryptogonimidae) with a Key to the Species

Abstract Caecincola aubergina n. sp. is described from white crappie (Pomoxis annularis) from B. A. Steinhagen Reservoir in southeastern Texas, U.S.A. Members of C. aubergina n. sp. have an elongate body (5.5–8.8:1 length:width ratio), a multilobed ovary, large vitelline follicles primarily in the hindbody but extending into the forebody, and an oral sucker that is wider than long. The elongate form of the new specimens distinguishes them from all other species in the genus except Caecincola longiscens and Caecincola cookorum. In the former species, vitelline follicles are confined to the hindbody; in the latter species, the body is peanut-shaped and the vitelline follicles are almost entirely in the forebody. This is the eighth species of Caecincola, and a dichotomous key to the species is presented as well.
Calcification in Octocorals

The octocorals are colonial cnidarians, many of which contain calcareous spicules in the mesoglea and, in some species, in the axis as well. The octocorals are excellent organisms for probing the mechanisms of biomineralization and demineralization, and the processes of calcification of spicules have been investigated extensively in recent years, especially in Leptogorgia virgulata. In this review, octocoral spicule formation is discussed relative to (1) the characteristics of scleroblasts, the spicule-forming cells, (2) calcium transport by the colonies, (3) rate of calcification, (4) role of carbonic anhydrase, (5) hormonal control of calcification, and (6) organic matrices and their possible functions in spicule formation.
Performative statements and the will: mechanisms of psychotherapeutic change.

Performative statements are much discussed in the philosophy of language, e.g., by the linguistic philosopher, J. L. Austin, where they are distinguished from descriptive statements. Whereas the latter merely describe a current state of affairs from an external standpoint, performative statements enact a new state of affairs merely by being spoken, as when a minister pronounces a couple married during a wedding ceremony. Performative statements are words and deeds at the same time. They are special kinds of statements, requiring certain unique circumstances and relationships so that they can function validly. Leston Havens has made the connection between the ability to make performative statements and the setting of psychotherapy. He has asserted that performative statements are an important part of the psychotherapeutic repertoire and may be an important force in bringing about psychotherapeutic change. In this paper, I try to locate the mechanism by which performative statements may achieve this effect, suggesting that this occurs by means of influencing the patient's will directly. Performative statements work on the will, much as descriptive statements influence the intellect. Philosophical ideas about the will, like Aristotle's notion of weakness of will, may explain some of the phenomena of psychotherapy, including resistance.
Getting help from Frank and Starling (and Coats and Bowditch) to augment blood flow in heat-stressed older adults.

Otto Frank and Ernest Starling are credited with the first observations that led to Starling's law of the heart, namely that the strength of cardiac contraction during systole is proportional to end-diastolic volume, or the amount of stretch on the myocardial muscle cells during diastole. This article is protected by copyright. All rights reserved
Teaching the Lochner Era

This article, prepared for the St. Louis University Law Journal's issue on “Teaching the Fourteenth Amendment,” develops a taxonomy of the Supreme Court's economic substantive due process jurisprudence during the so-called “Lochner Era” of the late-19th and early-20th centuries, and offers an assessment of the trajectory and mechanisms of the decline of that body of doctrine.
Loss of Limb-Bud-and-Heart (LBH) attenuates mammary hyperplasia and tumor development in MMTV-Wnt1 transgenic mice.

Abstract WNT/β-catenin signaling plays pivotal roles in mammary development and tumorigenesis; and aberrant activation of this pathway is frequently observed in human breast cancer, correlating with poor outcome. However, the mechanisms underlying WNT-driven mammary tumorigenesis remain incompletely understood. Here, we used mouse mammary tumor virus (MMTV)-Wnt1 transgenic mice, which develop aggressive mammary adenocarcinomas, to examine whether Limb-Bud-and-Heart (LBH) - a WNT/β-catenin target transcription co-factor overexpressed in human triple-negative breast cancers with WNT pathway hyperactivation, contributes to WNT-induced tumorigenesis. We found LBH is specifically overexpressed in basal epithelial tumor cells of MMTV-Wnt1 mammary tumors reminiscent of its basal cell-restricted expression in the normal postnatal mammary gland. To determine the role of LBH in mammary tumorigenesis, we crossed MMTV-Wnt1 mice with basal epithelial-specific Keratin 14/K14-Cre;LbhloxP knockout mice. Mammary glands from virgin LBH-deficient MMTV-Wnt1 mice exhibited reduced hyperplasia, cell proliferation and increased apoptosis. Importantly, LBH inactivation in mammary epithelium significantly delayed tumor onset in MMTV-Wnt1 transgenic mice, with a median tumor-free survival of 32.5 weeks compared to 22.5 weeks in control LBH wild type MMTV-Wnt1 mice (p
Braden scale for pressure ulcer risk predicts rehabilitation placement after pancreatic resection.

Abstract Background Patients undergoing pancreatic resection frequently require rehabilitation facilities after hospital discharge. We evaluated the predictive role of validated markers of frailty on rehabilitation facility placement to identify patients who may require this service. Methods Single-center retrospective cohort study of patients who underwent pancreatic resection from 2010 to 2015. 90-day morbidity and mortality were calculated. Postoperative validated markers of frailty (Activities of Daily Living scale, Braden scale [assesses pressure ulcer risk, lower scores = higher risk] and Morse fall scale) were evaluated via multivariate regression to identify predictors of discharge to rehabilitation facility. Results 470 patients with complete data were included. Mean age was 62 and 49.2% were male. Postoperative median length of stay (LOS) was 8 (IQR 7–10). 92 (19.66%) patients were discharged to rehabilitation facilities and 138 (29.49%) patients were readmitted within 90 days. On multivariate analysis, age, sex, LOS > 8 days, inpatient Comprehensive Complication Index (CCI) and initial Braden scale were predictive of rehabilitation placement. Conclusion A marker of frailty routinely collected daily by nursing staff, the Braden scale, is available to help surgeons predict the need for postoperative rehabilitation placement after pancreatic resection. Engaging discharge planning services for at-risk patients may help prevent delayed hospital discharge and should be further evaluated.
Perceptions & Experiences of Non-Muslim Minority Students on the Muslim Image

The purpose of this study is to explore non-Muslim minority students attending a minority-serving university in a rural community on their knowledge and experiences of the Muslim image. Research is dominated by majority-minority interactions and perspectives regarding subjective reports of controversial issues, especially the heightened awareness of Muslim image in the United States over the past two decades. This trend has perpetuated a growing gap in knowledge of understanding the unique minority-minority perceptions and the development of minority cultural awareness; therein, generating the motivation for this study. The researchers applied a qualitative assessment exploring non-Muslim understanding of foundational components associated with the Muslim image, such as basic Islamic vocabulary competencies and additional open-ended questions regarding experienced social interactions. From the responses of the participants stemmed five emerging themes: enculturation, geographic association, stigmatization, influencers, and empathy. These results demonstrate a general openness toward the Muslim identity but also include consistent misconceptions that may be easily rectified by interactive-educational interventions. The findings acknowledge the propensity of non-Muslim minority students’ willingness to learn from authentic Muslim image, despite the influence of disingenuous Muslim images depicted by current media outlets.
Age-Related Trends of Patients Undergoing Thyroidectomy: Analysis of US Inpatient Data from 2005 to 2013.

ObjectivesAs the country ages, thyroidectomies can be expected to be performed more frequently among the elderly. In this study, we stratified patients by age to explore demographics and complicati...
THE BIOLOGY OF RELATIONSHIPS: WHAT BEHAVIORAL GENETICS TELLS US ABOUT INTERACTIONS AMONG FAMILY MEMBERS.

Human behavior is subject to genetic variations. The ways in which individuals differ in their intellectual abilities, personalities, and mental health are, to a large extent, functions of their inherited genetic predispositions. Decades of research on twins, adoptees, and families have led to the inescapable conclusion that most reliably measured psychological characteristics are influenced to some degree by genes. Behavior also shows signs of genetic influence; the way one experiences stressful life events, for example, shows some genetic influence. Even personal aspects of individuals, such as spirituality and political ideology, are affected to an extent by genes.1 It should come as no surprise, then, that genes influence the ways in which families function and how family members relate to one another.2 Familial relationships of all kinds—parent-child, sibling, and spousal—can be shown to be at least partially the product of genetic factors. This Article discusses a behavioral genetic perspective that provides insight into the biological factors that influence family relationships. Part II presents a brief overview of the research methods used to understand both genetic and environmental influences on human behavior. Part III then discusses several key findings from the field of behavioral sciences, particularly how they pertain to the ways in which family members relate to one another. It focuses on the following: (1) characteristics of parents and variations in the ways they treat their own children; (2) characteristics of children and how they may react to their parents’ behavior; and (3) the interactive processes that occur between parents and children. While the primary focus of Part III is on parent-child relationships, Part IV considers sibling and spousal relationships. Part V discusses the general interpretation of family relationships from a behavioral genetic perspective.
Rapid one-step purification of the BChl-a containing FMO-protein from the green sulfur bacterium Chlorobium tepidum using a high efficiency immunomatrix.

A new and rapid procedure has been developed for the isolation of the bacteriochlorophyll a-containing Fenna—Matthews—Olson (FMO)-protein from green sulfur bacteria. Polyclonal antibodies raised against the FMO-protein of Chlorobium (Chl.) tepidum were employed in the preparation of an antibody column utilizing immobilized protein A as the matrix. The antibody column afforded essentially a one-step purification process, resulting in preparations that were free from contaminating pigments and proteins. This was evidenced by absorption spectroscopy, SDS—PAGE, and fluorescence emission.
Breast Cancer Screening Practices for High-Risk Women: A Cross-Sectional Survey of Primary Care Providers.

Background: Little literature exists on primary care providers' knowledge and preferences toward breast cancer screening for high-risk women. Materials and Methods: A cross-sectional web-based surv...
The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in epilepsy

Abstract The Epilepsy Therapy Screening Program (ETSP), formerly known as the Anticonvulsant Screening Program (ASP), has played an important role in the preclinical evaluation of many of the antiseizure drugs (ASDs) that have been approved by the FDA and thus made available for the treatment of seizures. Recent changes to the animal models used at the contract site of the ETSP at the University of Utah have been implemented in an attempt to better model the unmet clinical needs of people with pharmacoresistant epilepsy and thus identify improved therapies. In this review, we describe the changes that have occurred over the last several years in the screening approach used at the contract site and, in particular, detail the pharmacology associated with several of the animal models and assays that are either new to the program or have been recently characterized in more depth. There is optimism that the refined approach used by the ETSP contract site, wherein etiologically relevant models that include those with spontaneous seizures are used, will identify novel, potentially disease modifying therapies for people with pharmacoresistant epilepsy and those at risk for developing epilepsy. This article is part of the special issue entitled ‘New Epilepsy Therapies for the 21st Century – From Antiseizure Drugs to Prevention, Modification and Cure of Epilepsy’.
Coarse- and fine-scale acoustic telemetry elucidates movement patterns and temporal variability in individual territories for a key coastal mesopredator

Great barracuda (Sphyraena barracuda) are a high trophic level predator that uses a wide variety of habitats globally throughout tropical and subtropical waters. Despite the important top-down pressure this species likely exerts on fish communities within its foraging territories, the specifics of spatial ecology remain relatively unknown. This study tracked 17 great barracuda throughout Buck Island Reef National Monument, a marine-protected area located in St. Croix, U.S. Virgin Islands (17.786944° N, − 64.620556° W) from July 2014 to May 2016. Broad- and fine-scale acoustic telemetry was used to examine individual variability and study population patterns in residency, site fidelity, territoriality, and complexity of spatial use within home ranges. Network analysis of broad-scale data revealed spatial and temporal differentiation among the population in location of core use areas and showed that these areas contained multiple unique receiver groups or communities, a product of spatial or temporal variation within core activity spaces. Results from the fine-scale positioning system reinforced spatial and temporal partitioning in core use areas between individuals, indicating territorial behaviors, and showed evidence for both resident and transient movements. Preliminary fine-scale analysis also suggested diel variation in location of activity spaces. Although ubiquitous throughout all shallow water habitats, detection patterns for the study population appear to be influenced by high residency, territoriality, spatial partitioning, and diel variation. Understanding the complexities of individual space use is fundamental to ecologically founded and effective area-based spatial management frameworks at community scales.
Multi-arterial and total-arterial coronary revascularization: Past, present, and future perspective

Background and aim of the study Although abundant biological, clinical, and scientific evidence exists on the superiority of multi-arterial (MAR) and total-arterial revascularization (TAR) over the conventional strategy with a single internal thoracic artery, only 10% of patients undergoing coronary artery bypass grafting (CABG) in the United States receives a second arterial conduit, and only 5% of patients receives TAR. Methods and results In January 2020, the authors performed comprehensive search to identify studies that evaluated MAR and TAR strategies through the MEDLINE database. Conclusions In this paper, the authors reviewed the literature on the historical and current evidence in favor of MAR and TAR, thus underlying why current CABG practice needs qualitative improvement.
A 3D nm-thin biomimetic membrane for ultimate molecular separation

Multi-functional membranes with high permeance and selectivity that can mimic nature's designs have tremendous industrial and bio-medical applications. Here, we report a novel concept of a 3D nanometer (nm)-thin membrane that can overcome the shortcomings of conventional membrane structures. Our 3D membrane is composed of two three-dimensionally interwoven channels that are separated by a continuous nm-thin amorphous TiO2 layer. This 3D architecture dramatically increases the surface area by 6000 times, coupled with an ultra-short diffusion distance through the 2–4 nm-thin selective layer that allows for ultrafast gas and water transport, ∼900 l m−2 h−1 bar−1. The 3D membrane also exhibits a very high ion rejection (R ∼ 100% for potassium ferricyanide) due to the combined size- and charge-based exclusion mechanisms. The combination of high ion rejection and ultrafast permeation makes our 3DM superior to the state-of-the-art high-flux membranes whose performances are limited by the flux-rejection tradeoff. Furthermore, its ultimate Li+ selectivity over polysulfide or gas can potentially solve major technical challenges in energy storage applications, such as lithium–sulfur or lithium–O2 batteries.
La imagen “distorsionada”: sobre la relación entre perdón y deformidad en los textos Walter Benjamin

espanolLa imagen del jorobado que aparece aqui y alla en el corpus benjaminiano, una imagen que el mismo Benjamin califica como el prototipo de la distorsion (“dem Urbilde der Entstellung”) es tambien el prototipo del sujeto necesitado de perdon. Una lectura critica de los lugares en los que Benjamin refiere a esta “imagen distorsionada” ofrece la posibilidad de levantar una teoria del perdon (e, indirectamente, de la culpa y de la justicia) que no reduce el perdon a una forma juridica, a una particular dinamica emocional, o a un intercambio de condiciones morales, sino que la dota ademas de una clara dimension corporal que esta simplemente ausente en la mayoria de las consideraciones a proposito del perdon desarrolladas en el siglo XX. English“Distorted Picture: on the Relationship Between Forgiveness and Deformity on Walter Benjamin’s Worka”. The hunchback we find here and there in Benjaminian texts, an image that Benjamin himself describes as the prototype of the distortion (“dem Urbilde der Entstellung”) is also the prototype of the subject in need of forgiveness. A critical reading of the places in which Benjamin refers to this “distorted image” offers the possibility of raising a theory of forgiveness (and, indirectly, of guilt and justice) that does not reduce forgiveness to a legal form, to some specific emotional dynamics, or to an exchange of moral conditions. Instead, I argue the Benjaminian hunchback endows our common understandings of forgiveness with a clear bodily dimension that is simply absent in most contemporary considerations of the matter.
Learning in Collectives: How Maker Spaces Encourage Entrepreneurship and Innovation

Maker spaces have emerged as resource-rich learning environments for innovators attempting to design, prototype and produce new artifacts with commercial potential. This study examines the conditio...
Feasibility and Acceptability of an Abbreviated, Four-Week Mindfulness Program for Chronic Pain Management.

Objective The Mindfulness-Based Stress Reduction program is effective at improving chronic pain outcomes, but the time demand hinders participation. This preliminary study evaluated the feasibility, acceptability, and potential effects of providing an abbreviated mindfulness program for patients with chronic pain. Design A single-arm, mixed-methods, pre-post intervention study. Setting An outpatient rehabilitation clinic at an academic medical center. Subjects Participants were N = 23 adults with chronic pain who were new to mindfulness practice. Methods Mindfulness-based Stress Reduction was adapted to shorten the program to four weekly 90-minute sessions and to focus content on pain management. Three cohorts of six to nine participants completed baseline and post-treatment measures of 1) patient-reported outcomes, including pain intensity, pain interference, physical functioning, depressive/anxiety symptoms, positive affect and well-being, and sleep disturbance; 2) pain medication dosages; 3) psychosocial variables including pain acceptance, pain catastrophizing, and perceived stress; 4) dispositional mindfulness, as well as postintervention structured interviews about their experiences. Results Acceptable rates of retention and attendance and high ratings of satisfaction indicated that the intervention was feasible and acceptable. In interviews, participants found the program acceptable and beneficial and provided suggestions to improve it. From pre- to post-treatment, significant improvements were reported in all measures except physical functioning and anxiety. Conclusions In adults with chronic pain, a four-week mindfulness program is feasible and acceptable, addresses the barrier of a lengthy program, and may improve quality of life and psychological functioning. An appropriately powered randomized controlled trial with a comparison group is needed to assess the intervention's effectiveness.