cssi/SciSciGPT-SciSciNet huggingface dataset:
[Intravascular NK-cell lymphoma: a clinicopathologic study and literature review].

Objective To study the clinicopathologic features and disease outcome of intravascular natural killer-cell lymphoma (IVNKL). Methods The histologic features, immunohistochemical findings and results of in-situ hybridization for Epstein-Barr virus-encoded RNA (EBER) were analyzed in 2 novel cases of IVNKL. Seven cases of IVNKL previously reported in the literature were reviewed. Results The patients were a 68-year-old woman and a 22-year-old man. They both presented with erythematous patches and nodules on their trunk and extremities. Skin biopsies confirmed the diagnosis of IVNKL. The tumor cells were positive for CD3, CD56, granzyme B and EBER. Both patients died 2 months after the diagnosis.Amongst the 9 reported cases, including those from the literature, the male was 4 cases, the female was 5 cases. The mean age of the patients was 45.7 years and the median age was 47 years. Skin lesions represented the commonest clinical manifestations. Multiple organ involvement was found in 7 cases and central nervous system was involved in 3 cases. Six patients died during 2 to 17 months of follow-up. The median survival was 9 months and the one-year survival rate was (35.6 ± 18.6)％. The clinical outcome of the patients with multiple organ involvement was worse than that with skin manifestations only. The difference however was not statistically significant ( P = 0.083 ). Conclusions IVNKL is a rare disease.Diagnosis should be made according to typical histologic findings, immunophenotype and EBER in-situ hybridization results. The overall prognosis of IVNKL is poor. Early diagnosis and treatment before multiorgan involvement may be helpful in improving the clinical outcome. Key words: Lymphoma,T-cell ; Blood vessels; Immunophenotyping; Herpesvims 4, human; Prognosis
Wade Keyes' Introductory Lecture to the Montgomery Law School: Legal Education in Mid-Nineteenth Century Alabama

Abstract of David I. Durham and Paul M. Pruitt, Jr., editors, Wade Keyes' Introductory Lecture to the Montgomery Law School: Legal Education in Mid-Nineteenth Century Alabama (Tuscaloosa: University of Alabama School of Law, 2001). Iv, 45 pages, illustrations. Occasional Publications of the Bounds Law Library, Number Two. This book consists of essays by the editors, followed by an edited version of a lecture delivered by Wade Keyes (1821-1879) in March 1860 to the students of his Montgomery, Alabama, law school. Keyes was already a scholar of some note, a recognized authority on future interests and a former Chancery Court judge. His school lasted only a year before the onset of the Civil War forced him to close it, but Keyes showed the quality of his mind in his introductory lecture, printed at the request of his students and here presented in typographical facsimile. In it he proposes study and work habits appropriate to students and seasoned professionals alike quoting extensively from Coke. He also discusses economic and ethical aspects of the profession, with many references to literary works both classical and modern, and to contemporary events. David Durham's "Introduction to Wade Keyes and the Montgomery Law School" outlines Keyes' biography, tracing his legal and educational careers, his service with the Confederate Department of Justice, and his subsequent work as a code commissioner. Paul Pruitt's "Law and the Life of the Mind: Wade Keyes as Legal Educator" puts the lecture into pedagogical and ethical context.
Preservation of Distal Splenorenal Shunt in a Patient Requiring Left Nephrectomy

We report a case in which a prior distal splenorenal shunt for bleeding esophageal varices was preserved during subsequent left nephrectomy for adenocarcinoma. At nephrectomy portal hypertension with numerous collateral varices to the splenic vein was not a major technical problem. Shunt integrity was documented by postoperative angiography.
Surgical treatment of severe hallux valgus: the state of practice among academic foot and ankle surgeons

Background:The purpose of this study was to evaluate the operative procedures used for treatment of severe hallux valgus by academic foot and ankle surgeons practicing in the United States.Methods:...
Genes and Genetics of Murine Systemic Lupus Erythematosus

Murine lupus encompasses a diverse collection of spontaneous, modified, and induced models that has provided the means to identify and characterize genetic risk variants in experimental settings. What has been discovered about the genetics of lupus mice has not only informed about the lupus-promoting potential of a large number of genes, but has also contributed to identifying and understanding the genetic basis for key pathways in disease pathogenesis including the noninflammatory disposal of self-nucleic acids, B-cell production of autoantibodies, and end-organ susceptibility. Importantly, these findings overlap observations acquired in human SLE genetic studies. Consequently, as the focus shifts toward characterizing the function of risk variants, genetic studies of murine lupus models have remained an important complementary resource, particularly with the recent arrival of more efficient cost-effective methodologies to modify the mouse genome.
Patterns of Pugilism: Rocco e i suoi fratelli (1960) and the Boxing Film

Visconti's family melodrama reflects boxing's ascendency in Italian popular culture in the 1940s and 1950s, fuelled by the favourable results of Italian boxers in the ring and numerous Hollywood and Italian boxing films in theatres. An examination of this cinematic intertext in the preparation, production, and presentation of the film reveals a disruption to any ontological link between the film and the migrant crisis, introducing generic codes not normally associated with an auteur like Visconti. Moreover, attention to the body of the boxers redirects criticisms that Visconti embedded a personal, racist perspective on southern Italians within Rocco e i suoi fratelli. How this cinematic archetype was deployed to narrativize a hot-button social issue highlights the limits of the canonical means for interpreting the film: neorealism, adaptation, and impegno.
Performance Modeling: A Data Scientific Operationalization of Tilly's Theory

This article aims to revitalize and extend Charles Tilly’s theory of contentious performances by presenting a new and fruitful method for discovering, measuring, and modeling them. The article begins with a restatement of Tilly’s theory that performances are flexible, semi-scripted sets of coherent action occurring within protest events (i.e., contentious gatherings), then describes how Tilly attempted to measure performances. Next, it describes a novel method for discovering performances that efficiently merges hand-coding and automated text analysis techniques. The merits of the approach are demonstrated across three studies of news data reporting on the Occupy movement of 2011. The first shows that the method is able to easily identify performances common to the social movements repertoire, such as marches and demonstrations. The second shows that the method can identify performances common to the Occupy movement but rarely included in event catalogues, like setting up encampments and targeting banks. The third study discovers performances never before measured in quantitative studies: performances that only occur through the interaction of protesters and police. These ‘dances,’ namely curfew disputes and traffic battles, highlight the need for more research understanding the relationships between intra- and trans-event conflict for social movement campaign outcomes. The article discusses how its novel approach is both more efficient to put into practice and much more adequate to Tilly’s theory of performances than traditional hand-coding approaches. The article then previews future work, discussing how the approach may be used to model the incidence of various performances as a function of political opportunity structures, and the temporal location of an event within a longer movement campaign. The article concludes with an invitation to use and improve upon the performance modeling approach.
Quantifying the volatility of organic aerosol in the southeastern US

Abstract. The volatility of organic aerosols (OA) has emerged as a property of primary importance in understanding their atmospheric life cycle, and thus abundance and transport. However, quantitative estimates of the thermodynamic (volatility, water solubility) and kinetic parameters dictating ambient-OA gas-particle partitioning, such as saturation concentrations (C∗), enthalpy of evaporation (ΔHvap), and evaporation coefficient (γe), are highly uncertain. Here, we present measurements of ambient-OA volatility at two sites in the southeastern US, one at a rural setting in Alabama dominated by biogenic volatile organic compounds (BVOCs) as part of the Southern Oxidant and Aerosol Study (SOAS) in June–July 2013, and another at a more anthropogenically influenced urban location in North Carolina during October–November 2013. These measurements applied a dual-thermodenuder (TD) system, in which temperature and residence times are varied in parallel to constrain equilibrium and kinetic aerosol volatility properties. Gas-particle partitioning parameters were determined via evaporation kinetic model fits to the dual-TD observations. OA volatility parameter values derived from both datasets were similar despite the fact that measurements were collected in distinct settings and seasons. The OA volatility distributions also did not vary dramatically over the campaign period or strongly correlate with OA components identified via positive matrix factorization of aerosol mass spectrometer data. A large portion (40–70 %) of measured ambient OA at both sites was composed of very-low-volatility organics (C∗ ≤ 0.1 µg m−3). An effective ΔHvap of bulk OA of ∼ 80–100 kJ mol−1 and a γe value of ∼ 0.5 best describe the evaporation observed in the TDs. This range of ΔHvap values is substantially higher than that typically assumed for simulating OA in atmospheric models (30–40 kJ mol−1). TD data indicate that γe is on the order of 0.1 to 0.5, indicating that repartitioning timescales for atmospheric OA are on the order of several minutes to an hour under atmospheric conditions. The OA volatility distributions resulting from fits were compared to those simulated in the Weather, Research and Forecasting model with Chemistry (WRF/Chem) with a current treatment of secondary organic aerosol (SOA) formation. The substantial fraction of low-volatility material observed in our measurements is largely missing from simulations, and OA mass concentrations are underestimated. The large discrepancies between simulations and observations indicate a need to treat low-volatility OA in atmospheric models. Volatility parameters extracted from ambient measurements enable evaluation of emerging treatments for OA (e.g., secondary OA using the volatility basis set or formed via aqueous chemistry) in atmospheric models.
The association between alcohol consumption and breast density: a systematic review and meta-analysis.

Background: Percent breast density (PBD) is a strong risk factor for breast cancer that is influenced by several other risk factors for the disease. Alcohol consumption is associated with an increased risk of breast cancer with an uncertain association with PBD. We have carried out a systematic review and meta-analysis to examine the association of alcohol consumption with PBD. Methods: We searched nine databases to identify all relevant studies on the association between alcohol intake and breast density. Two independent investigators evaluated and selected 20 studies that were included in our analyses. We divided the studies into three groups according to the methods used to measure and analyze the association of breast density with alcohol consumption. Results: Meta-analysis of the 11 studies that used quantitative methods to measure and analyze PBD as a continuous variable found a statistically significant difference in PBD when comparing the highest with the lowest alcohol level [β = 0.84; 95% confidence interval (CI), 0.12–1.56]. Three studies that used quantitative methods to measure PBD and categories of PBD for analysis had a summary OR = 1.81 (95% CI, 1.07–3.04). Five studies that used categories to classify PBD and analyze their association with alcohol intake had a summary OR = 1.78 (95% CI, 0.90–3.51). Conclusions: These results suggest that there is a positive association between alcohol intake and PBD. Impact: Alcohol may increase the risk of breast cancer associated with PBD. Cancer Epidemiol Biomarkers Prev; 26(2); 170–8. ©2016 AACR.
Assessing subsets of analytes in context of detecting laboratory errors

Laboratory error detection is a hard task yet plays an important role in efficient care of the patients. Quality controls are inadequate in detecting pre-analytic errors and are not frequent enough. Hence population- and patient-based detectors are developed. However, it is not clear what set of analytes leads to the most efficient error detectors. Here, we use three different scoring functions that can be used in detecting errors, to rank a set of analytes in terms of their strength in distinguishing erroneous measurements. We also observe that using evaluations of larger subsets of analytes in our analysis does not necessarily lead to a more accurate error detector. In our data set obtained from renal kidney disease inpatients, calcium, potassium, and sodium, emerged as the top-3 indicators of an erroneous measurement. Using the joint likelihood of these three analytes, we obtain an estimated AUC of 0.73 in error detection.
Parenting Practices and Emotion Regulation in National Guard and Reserve Families: Early Findings from the After Deployment Adaptive Parenting Tools/ADAPT Study

While a caregiver’s military status per se is not a risk factor for children’s adjustment, deployment is a significant family stressor, which places children at risk for behavior and emotional problems. We hypothesize that deployment (i.e. separation from spouse and child(ren), exposure to combat, reintegration, and further deployment) may impair parenting by influencing parents’ emotion regulation capacities. We report baseline data from the After Deployment: Adaptive Parenting Tools study, an NIH-funded effectiveness study of a parenting program for Reserve component families. Data were gathered from N = 89 military and civilian parents in families where a parent had deployed to the current conflicts. Parents completed self-report measures of emotion regulation, and parenting. On average, deployed individuals (N = 52) reported more difficulties in emotion regulation than civilian parents. Across gender, mothers reported more difficulties than fathers with deployed mothers reporting the most difficulties. Emotion regulation explained a significant proportion of the variance in parenting practices, and associations of deployment to parenting and emotion regulation approached significance in a regression analysis. Results are discussed in the context of the challenges facing deployed parents—particularly mothers—and the potential for programs targeting parenting in military families experiencing deployment.
Prediction of convection from a finned cylinder in cross flow using direct simulation, turbulence modeling, and correlation-based methods

ABSTRACTDirect numerical simulation (DNS), two shear-stress transport (SST) turbulence models, and three k-e models are used to predict mixed convection associated with air in cross flow over an isothermal, finned cylinder. The DNS predictions reveal complex time-variation in the flow field. Convection heat transfer coefficients predicted by the SST models are in good agreement with those generated by DNS, whereas the k-e models do not accurately predict heat fluxes. Correlation-based predictions of heat transfer coefficients are, in general, in poor agreement with the DNS and SST predictions. The impact of various geometrical modifications on convection coefficients is also presented.
Inherited DNA repair gene mutations detected by tumor next generation sequencing in urinary tract cancers

Interpretation of next-generation sequencing (NGS) of tumor tissue in patients with advanced Urinary Tract Cancer (UTC) is performed to guide treatment selection but may reveal pathogenic variants with germline implications. We identified three patients with UTC with unexpected germline DNA repair gene mutations. Specific testing for these was prompted by the detection of these mutations by tumor NGS. All three patients were nonsmokers with a strong family history of cancer. Two patients had upper tract UTC with age at diagnosis in the 40 s. One had a family history suggestive of hereditary breast/ovarian predisposition and a FANCA mutation detected on NGS was confirmed to be germline. The second patient had a family history suggestive of Lynch syndrome but was found to have a germline BRCA2 mutation that was suggested by NGS. The third patient had bladder cancer at an advanced age, a family history of late-onset gastrointestinal malignancies that did not meet criteria for clinical testing for a hereditary cancer predisposition syndrome. NGS identified an MUTYH mutation, and targeted testing confirmed a monoallelic germline MUTYH mutation. Detection of variants with germline implications by tumor NGS may be clinically relevant for patients and their families and warrant genetic counseling and germline genetic testing. The prevalence of germline DNA repair defects in the context of inherited predisposition to UTC merits further study.
Symptom management challenges in heart failure: pharmacotherapy considerations

Heart failure is a chronic, progressive illness that is increasing in prevalence in the USA. Patients with advanced heart failure experience a high symptom burden that is comparable to patients with advanced cancer. Palliative care, however, is underutilized in patients with heart failure, and symptoms may go untreated as the disease progresses. A combination of pharmacologic and non-pharmacologic interventions should be used to address symptoms and maintain quality of life. While there have been significant advances in evidence-based heart failure treatments in recent years, selection of appropriate palliative medications as symptoms progress is challenging due to limited clinical studies in this patient population. Medications that are commonly used for symptom management in other life-limiting illnesses may have little to no evidence in heart failure, or have undesirable cardiac effects that preclude use. Clinicians must extrapolate available clinical evidence and prescribing considerations relevant to heart failure to palliate symptoms as well as possible. The objectives of this paper are to review the most common and distressing symptoms in heart failure, analyze evidence, or lack thereof, for pharmacologic management of symptoms, and provide prescribing considerations based on side effect profiles and comorbid conditions.
Consumption of intentional food subsidies by a hunted carnivore

Wildlife consumption of human foods is common and these subsidies can alter a species’ behavior, demography, and interspecific interactions, and lead to conflicts with humans. Intentional food subsidies, including feeding or baiting of wildlife for viewing or hunting, can represent a large energy source. We studied consumption of bait for an American black bear (Ursus americanus) population in northern Wisconsin. Given the state's liberal baiting regulations, we hypothesized that bear baits would be highly available, and that bears would readily consume such baits within a hunting season. We documented the abundance of bear bait on forestlands, and quantified the diets of harvested black bears using stable isotopes and Bayesian mixing models to determine the relative contribution of human foods to individual and population diets. Baits occurred at ≥0.25 bait stations/km2 on public lands, and bears (n = 180) were subsidized by these baits, which contributed to >40% of their diet. Our analysis of multiple tissue types with different turnover rates revealed that harvested bears were relying on subsidies throughout their lifetimes. Patterns of bait consumption were primarily influenced by age-sex class; adult males were the most reliant on human foods, followed by adult females. We found a high level of food subsidization in this bear population. We posit that the high density of bears in northern Wisconsin may be partly due to subsidies. Our results reveal how baits used for hunting can become an important resource for free-ranging bears and highlight the importance of considering potential consequences when bait is used in harvest management. © 2017 The Wildlife Society.
Seating, Console, and Workplace Design: Integration of Literature and Accommodation Model

In this paper, a procedure for determining the percentage excluded from a seat-console design, given the percentage excluded on individual dimensions is described. Seven critical anthropometric variables for seat-console design were identified. A “computerized accommodated percentage evaluation (CAPE)” model was used to determine the percentage excluded on the total design of a seat console as critical limits were imposed on each individual anthropometric dimension. Results of this paper are applicable to meeting MIL-STD-1472B criteria for accommodating 90 percent of the potential user population.
Education mirrors industry: on the not-so surprising rise of internet distance education

Internet distance education is analyzed as a natural consequence of fin de siecle industrial transformations. From this perspective, previous distance-and technologically-based educational innovations are discussed, not as having failed, but as not matching prevailing economic and social conditions. It is argued that in the evolution from a manufacturing economy, in which standard educational practices are based, to an information economy, in which greater autonomy, collaboration, flexibility, and a project orientation to work are the norm, educational practices will either follow the lead of industrial organizations or risk irrelevance. Implications for adapting educational practices to new economic realities and developing new research streams are presented, especially in terms of matching instructional technology to educational outcomes, virtual collaboration, and media naturalness effects.
Surface engineered excipients: I. improved functional properties of fine grade microcrystalline cellulose.

Excipients with good flowability, bulk density as well as compaction properties are desired for use in tableting since they play important roles in formulation development and processing, including, handling, mixing, feeding and compaction. The objective of this paper is to examine the feasibility of using dry coating based surface modification of microcrystalline cellulose, Avicel PH-105, to produce an engineered fine grade (<30 μm) excipient that has all three desired properties. Using a material sparing high-intensity vibrational mixer, Avciel PH-105 is dry coated with 1 wt% Aerosil 200, selected due to its relatively higher dispersive surface energy and lower particle size amongst other silica choices. The results indicated that as expected, the bulk density and flowability are significantly improved, while there was an appreciable loss of compaction. To minimize the loss of compaction, attributed to decreased surface energy after coating, while maintaining improved bulk density and flowability, the effect of reduced silica amount was examined. Remarkably, at reduced levels (0.5 wt% to 0.7 wt%) of Aerosil 200, significant improvements in bulk density and flowability were attained with only 9%–12% compaction reduction. The properties of the surface-engineered excipients were compared with several other commercially available pharmaceutical excipients using two different processibility or regime maps; tablet tensile strength versus bulk density or flow function coefficient (FFC). The surface engineered excipients exhibited the best overall performance establishing a promising pathway to engineer excipients using dry processing instead of complex processes such as spray drying.
Maintaining nano-lamellar microstructure in friction stir welding (FSW) of accumulative roll bonded (ARB) Cu-Nb nano-lamellar composites (NLC)

Abstract Accumulative roll bonded (ARB) Copper Niobium (Cu-Nb) nano-lamellar composite (NLC) panels were friction stir welded (FSWed) to evaluate the ability to join panels while retaining the nano-lamellar structure. During a single pass of the friction stir welding (FSW) process, the nano-lamellar structure of the parent material (PM) was retained but was observed to fragment into equiaxed grains during the second pass. FSW has been modeled as a severe deformation process in which the material is subjected to an instantaneous high shear strain rate followed by extreme shear strains. The loss of the nano-lamellar layers was attributed to the increased strain and longer time at temperature resulting from the second pass of the FSW process. Kinematic modeling was used to predict the global average shear strain and shear strain rates experienced by the ARB material during the FSW process. The results of this study indicate that through careful selection of FSW parameters, the nano-lamellar structure and its associated higher strength can be maintained using FSW to join ARB NLC panels.
Methods for Statistical Analysis of Reliability and Life Data

(1977). Methods for Statistical Analysis of Reliability and Life Data. Journal of Quality Technology: Vol. 9, No. 1, pp. 44-45.
Do environmental toxicants contribute to allergy and asthma

The rates of asthma and allergy (Type 1 hypersensitivity disorders) have been increasing worldwide for the last few decades. Various theories have been proposed to account for this alarming trend. One of these is the impact of environmental toxicants. Epidemiological research has correlated exposure to environmental chemicals (such as pesticides, solvents, and air pollutants) with increasing rates of both asthma and allergies. Research has documented chemicals as causal agents capable of producing immune system imbalances characteristic of type 1 hypersensitivity. In vitro studies and in vivo animal models have demonstrated that many of the environmental chemicals and pollutants that have been epidemiologically associated with increased allergic tendency have been shown to enhance Type 2 helper T cell (Th2) dominance, which is consistent with the T-helper cell pattern found in asthma, allergic rhinitis, and other Type 1 hypersensitivity disorders. Depletion of glutathione is one possible mechanism for this T-helper cell imbalance. Preliminary evidence suggests the possibility that repletion of glutathione levels (with oral supplementation of N-acetylcysteine), and enhancement of glutathione transferase function (using sulforaphanes), might be therapeutic options for countering type 1 hypersensitivity disorders caused by environmental chemicals.
Intraperitoneal Chemotherapy: Phase III Trials

It is well documented that epithelial-type ovarian cancer growth remains within the intraperitoneal (IP) space for the majority of its natural history, making even advanced disease (e.g., stage III) amenable to regional therapy. The concept of IP delivery of chemotherapy goes back more than 40 years to the bioengineer, Robert Dedrick, whose research group at the National Institutes of Health developed animal and mathematical models to describe the disposition of cytotoxic agents administered directly into the IP space [1]. Most notably, his preclinical research led to the “belly bath” as a way of delivering cell-cycle specific agents by continuous 4 h infusions, leading to phase I/II clinical trials of IP 5-fluorouracil and methotrexate in patients with advanced ovarian cancer at the National Cancer Institute (NCI) [2, 3].
Pursuing risk or insight. Marketing adventures.

Abstract Adventure tourism is often envisioned as outdoor activity where the participant confronts nature in order to experience risk. Such models are ill-suited for facilitating the marketing of many types of adventure tourism pursued by those who embrace certain cultural and personal styles. This paper distinguishes between risk-taking adventure and that which is pursued to gain knowledge or insight. In North America, both are strong traditions. Tourism scholars and practitioners should recognize this distinction and the fact that they are pursued by different kinds of target markets. Discussing adventure tourism in broader perspectives which include the participants' cultural orientation and psychological styles, a more general model is presented.
High-Performance Few-Layer Tellurium CMOS Devices Enabled by Atomic Layer Deposited Dielectric Doping Technique

Tellurium (Te) is a p-type narrow bandgap (0.35 eV, direct) semiconductor with high hole mobility around 700 cm2/Vs. [1] The lattice of Te is formed by 1D helical atomic chains and the neighboring chains are interconnected by van der Waals forces as shown in Fig. 1(a) [2]. Recently a liquid-based synthesis method was proposed to produce high-quality large-area 2D tellurium films with atomic flat surfaces [1], and high-performance p-MOSFETs based on few-layer tellurium films were demonstrated with large on-state current ( $(> 1$ A/mm), high on/off ratio (∼106) and great stability for over two months in air [1]. However, like most of other 2D materials, the lack of doping techniques [3], [4] to obtain its counterpart n-FETs is a major roadblock against the realization of Te CMOS or steep-slope devices. In this paper, for the first time, we demonstrated Te n-FETs enabled by atomic layer deposited (ALD) dielectric doping technique with large drive current (200 mA/mm) and reasonable on/off ratio (∼103). The n-FETs show almost symmetric operation as p-FETs and comparable field-effect mobility of 612 cm2/Vs. Using low work function metal, the on-state contact resistance is reduced to $4.3 \mathrm{k}\Omega\cdot\mu \mathrm{m}$ . The impacts of oxide layer type and thickness on doping effect are also systematically studied.
Abstract WP87: Remote Pre-, Per, and Postconditioning of Cerebral Ischemia in Preclinical Models: Comprehension of Mechanisms for Translation to Clinical Trials

Background: Limb remote ischemic conditioning is a series of mechanical interruptions that alters the hydrodynamics of reperfusion of a remote, distal organ or limb rendering a significantly reduce...
ESG Risks and the Cross-Section of Stock Returns

This paper finds that environmental, social, and governance (ESG) risks generate negative long-run stock returns. A value-weighted portfolio of firms with high ESG risks exhibits a four-factor alpha of −3.5% per year, even when controlling for other risk factors, industries, or firm characteristics. The negative alpha stems from unexpected costly ESG incidents and from negative earnings surprises. These findings make three contributions. First, weak corporate social responsibility (CSR) destroys shareholder value. Second, stock markets fail to incorporate the consequences of intangible risks. Third, shorting firms with high ESG risks is a profitable socially responsible investing (SRI) strategy.
Condition C reconstruction, clausal ellipsis and island repair

This paper makes two related but distinct claims concerning the relationship between islandhood and the clausal ellipsis construction known as stripping. The first claim is that (at least a certain version of) this construction is island insensitive: no unacceptability results from having a correlate inside an island. This claim is supported by evidence from a formal acceptability judgment study. The second claim concerns the question of how to best account for this phenomenon of island- insensitivity in stripping: we claim that this island-insensitivity is best explained via the notion of island-repair, i.e., the ellipsis site involves the structure of island yet the ellipsis operation ameliorates island violations as opposed to the alternatives that have been dubbed evasion approaches. By this we mean that the island-insensitivity cannot be explained by positing a smaller, non-island structure in the ellipsis site; while this approach does of course explain the lack of an island effect, we show that it is incompatible with other facts about the crucial example sentences. If we instead assume that movement out of an island is grammatical if the island is properly contained inside a clausal ellipsis site, then positing a complete island structure inside the ellipsis site can explain all the properties of these crucial examples.
Regional Anesthesia/MAC

Monitored anesthesia care (MAC) is an alternative to general anesthesia for surgical procedures that are noninvasive and short in nature, or that utilize regional anesthesia. Sedatives and analgesics are given, by an anesthesia provider trained in airway management, in a fashion that promotes respiratory function and spontaneous ventiation, yet provides amnesia and analgesia. Patients and surgeons favor MAC over general anesthesia due to the quicker recovery and pain control it provides when used in conjunction with a regional anesthetic. Multiple factors contribute to whether a MAC is appropriate for a certain patient. In most instances MAC is very safe, however, the anesthesia provider needs to be aware of potential complications that can arise using MAC.
Mechanical, inflammatory, and embolic complications of myocardial infarction: An emergency medicine review

Abstract Introduction Despite the declining incidence of coronary heart disease (CHD) in the United States, acute myocardial infarction (AMI) remains an important clinical entity, with many patients requiring emergency department (ED) management for mechanical, inflammatory, and embolic complications. Objective This narrative review provides an evidence-based summary of the current data for the emergency medicine evaluation and management of post myocardial infarction mechanical, inflammatory, and embolic complications. Discussion While 30-day mortality rate after AMI has decreased in the past two decades, it remains significantly elevated at 7.8%, owing to a wide variety of subacute complications evolving over weeks. Mechanical complications such as ventricular free wall rupture, ventricular septal rupture, mitral valve regurgitation, and formation of left ventricular aneurysms carry significant morbidity. Additional complications include ischemic stroke, heart failure, renal failure, and cardiac dysrhythmias. This review provides several guiding principles for management of these complications. Understanding these complications and an approach to the management of various complications is essential to optimizing patient care. Conclusions Mechanical, inflammatory, and embolic complications of AMI can result in significant morbidity and mortality. Physicians must rapidly diagnose these conditions while evaluating for other diseases. In addition to understanding the natural progression of disease and performing a focused physical examination, an electrocardiogram and bedside echocardiogram provide quick, noninvasive determinations of the underlying pathophysiology. Management varies by presentation and etiology, but close consultation with cardiology and cardiac surgery is recommended.
After the Flood: Reflections of a Wounded Healer’s Countertransference in Adolescent Treatment

The aim of this paper is to analyze countertransference experienced by a therapist while treating a ‘difficult to treat’ adolescent client. In doing so, the therapist discusses how his childhood experiences and the subsequent assumption of Carl Jung’s wounded healer archetype fueled the countertransference in ways that were concurrently beneficial and detrimental to treatment. The client’s symptoms, behavior, and family system are also examined to illustrate how they uniquely contributed to the intense feelings evoked in the therapist. Topics of omnipotence, curative fantasies, biblical myth, and childhood trauma are explored throughout this paper, as they uniquely intersected to create a complex web of psychodynamics between therapist and client. This is demonstrated primarily through an interpretation of the client’s final session and the therapist’s dream following treatment. The therapist shares reflections of the treatment, implications for wounded healer self-disclosure, as well as the archetype’s importance to the social work profession.
An integrated simulation-optimization framework to optimize search and treatment path for controlling a biological invader

Abstract Invasive species cause large economic losses and are difficult to control due to the high cost of locating and treating the continual emergence of new individuals. The national strategy against invasive species encompasses prevention, early detection, and rapid response. In particular, determining an optimal route for search and treatment under limited budget is critical to reducing management costs. In this paper, we present a new integrated simulation-optimization framework to effectively search and treat invasive species under a limited management budget. The simulation mimics invader growth over a landscape and 12 years, while a bio-economic optimization model finds an optimal search and treatment path to minimize its economic damage to agricultural production. Our optimization model is new in the sense that it prescribes the optimal path for searching and treating sites for controlling the invader. This study is also the first in the literature to present and combine simulation and optimization models of the complex bio-economic search-path problem, and to prescribe a pathway for search and treatment that is applicable to the real-world management of invasive species. Our case study data and parameter calibration are based on the large-scale field data on Sericea, an aggressive invasive plant threatening the Great Plains of the U.S., collected over twelve pastures in Kansas during the past two years. Solving simulation and optimization models in a consecutive fashion provides a considerable computational advantage to find an optimal solution to practical size problems in a reasonable time. Our results imply that applying yearly treatment with a slow search-and-treatment speed results in the biggest bang for the buck under most invasion scenarios.
Exploring Cost and Environmental Implications of Optimal Technology Management Strategies in the Street Lighting Industry

Abstract The market for solid-state lighting (SSL) systems has expanded 40-fold in installed lamps since 2001. At the same time, systems which preserve materials over time and promote material reuse are getting increasing attention in light of calls for reducing consumption of natural resources. As new lighting technology products are designed and brought to market, consideration must be given to how products will be managed throughout the life-cycle as well as their end-of-life (EOL) fate. Lighting-as-a-service (LaaS) business models have emerged as a potential strategy for preserving the materials embedded in lighting products. In this paper, we examine the cost and environmental implications of technology management decisions in the context of the street lighting industry, employing life-cycle assessment and a Markov Decision Process model. The goal of the research is to determine a policy that minimizes expected costs and emissions for the system over a fixed time horizon thus reducing uncertainty for managers. The model used in the paper evaluates the optimal replacement strategies for street lighting products and additionally connects the result to the optimal EOL product trajectory, taking both costs and carbon emissions into account. In doing so, we are able to more deeply understand the role that LaaS business models might play in enabling closed-loop systems within the street lighting industry.
Sitagliptin-induced Pancreatitis: Chronic Use Would Not Spare You the Complication.

Medication-induced pancreatitis is an overlooked cause of acute pancreatitis. We present an 81-year-old male patient with acute sharp epigastric pain radiating to his back, who was found to have lipase of more than 30,000 U/L. The patient denied current alcohol use. Abdominal ultrasound and abdominal computed tomography scan revealed no gallstones or biliary duct abnormalities. The patient had been taking sitagliptin for eight years. Supportive treatment with intravenous fluids, pain medications, and early feeding adequately treated his disease. With our case, we aim to increase awareness of sitagliptin-induced pancreatitis, regardless of the duration of use.
A Read-the-Bill Rule for Congress

In this Article, I argue that legislators have a duty to read the text of proposed legislation before voting to enact it. A Read the Bill political movement has formed in response to recent high-profile instances of rushed legislation. Putting aside partisan concerns, a rushed legislative process creates real problems because it forces legislators to vote on bills without having the time to properly evaluate the new legal rules that are being imposed on citizens. If a rule or norm of reading the bill can slow the legislative process enough to provide for thorough consideration of proposed legislation, it would bring a substantial benefit in the form of better laws. The rule would also draw the attention of legislators to their primary, fundamental role of making good law.
Toward mitigating microcracks using nanopowders in laser powder bed fusion

Selective laser melting (SLM) is an additive manufacturing (AM) process capable of fabricating parts of intricate shapes and sizes by melting layers of metal powder with high accuracy. Nickel–Titanium (NiTi) is a shape memory alloy with superelastic characteristics which is of great interest to modern industries. The conventional fabrication of NiTi is limited due the poor machinability of NiTi. Thus, modern manufacturing techniques like SLM enables the fabrication of complex NiTi specimens to suit its application. Nevertheless, microstructural defects such as porosities and microcracks often lead to decreased ductility in SLM fabricated NiTi specimens. In this study, a new technique is used in order to deposit nano metal powders over already formed microcracks, followed by their melting, in order to reduce these microstructural defects. The as-fabricated additive manufactured NiTi sample with the novel nanoparticle dispersion technique exhibited a reduction of 98% in crack density.
Experimental Evaluation of Test Methods to Characterize Tensile Behavior of UHPC

Ultra-high performance concrete (UHPC) is a relatively new class of concrete material that exhibits exceptional mechanical and durability properties compared to traditional concrete. Unlike normal concrete, UHPC has a sustained post-cracking tensile strength due to the presence of steel fibers and strain hardening of the fibers. The tensile response of UHPC plays an important role in the design of structural members. However, currently there is no standard test method available to reliably characterize the tensile behavior of UHPC. There are several experimental methods available in literature to quantify the tension behavior of steel fiber-reinforced concrete. The test methods include the disk-shaped compact tension (DCT) test, double-edge wedge-splitting (DEWS) test, single-edge notched beam specimen (SEN(B)), and four-point beam bending test. FHWA is currently developing a direct-tension test procedure for quantifying UHPC tension behavior. A total of 47 specimens, including at least 6 specimens for each type of test, were constructed using a commercially available UHPC mix and were tested to failure using standard test procedures. Using experimentally measured force-displacement response, fracture parameters and tensile stresses were calculated for different test methods. This paper presents details of the experimental investigation, observations, and observed correlation between the tension behavior obtained from the conducted tests.
Evoking gender distinctiveness threat in cisgender women lowers their support for gender-inclusive bathroom policies:

Some cisgender women oppose policies granting transgender women access to women-only bathrooms. We examined whether this opposition stems from perceiving that transgender women threaten the distinc...
Coaching Parents of Young Children with Autism in Rural Areas Using Internet-Based Technologies: A Pilot Program:

The purpose of this paper is to describe a pilot program (i.e., Internet-Based Parent-Implemented Communication Strategies [i-PiCS] program) that provides long-distance training and coaching via th...
Disposable blast shields for use on NIF imaging diagnostics

The NIFs 192 lasers can deliver 2 MJ of energy to Target Chamber Center (TCC) to produce environments not available in any other experimental laboratory. The NIFs ability to deliver such intense energy to a small volume causes harsh consequences to experimental equipment and supporting diagnostics such as holhraums, support packages, target positioners, diagnostic equipment, and laser optics. Of these, the hohlraum and support packages are typically quickly vaporized and transformed into an expanding shell of high-hypersonic gases referred to as debris wind. During an experimental event such as fusion implosion, the target diagnostic components used to measure key observables in the experiment are subjected to extreme pressures and impact shocks due to incident debris wind loading. As diagnostics are positioned closer to TCC, the diagnostic pinhole stacks and other components along the diagnostic structure become more likely to be at or above the yield strength of the materials commonly used. In particular, the pinhole stack components and data recording instruments behind the pinholes are the most costly to replace. Thus, a conceptual configuration for a pinhole shield is proposed, analyzed, and tested with the intent of mitigating damage to the pinhole stack and imaging equipment and allowing immediate re-use of this diagnostic equipment. This pinhole shield would be a replaceable window that can be replaced quickly by inserting and removing it before and after each experimental laser shot, which will allow NIF to benefit from significant material and labor costs.
Isolation and sequence of cDNA clones encoding rat phosphatidylinositol transfer protein.

Abstract Phosphatidylinositol (PtdIns) transfer protein is a cytosolic protein that catalyzes the transfer of PtdIns between membranes. It is expressed in organisms from yeast to man, and activity has been found in all animal tissues examined. Using antibodies prepared against bovine brain PtdIns transfer protein, lambda gt11 rat brain cDNA libraries were screened and several clones isolated. DNA sequence analysis showed that the cDNAs encoded a polypeptide of 271 amino acids with a mass of 31,911 Da. Comparison of the deduced amino acid sequence with N-terminal sequence data obtained for the intact purified bovine brain protein and rat lung phospholipid transfer protein verified that the cDNAs were PtdIns transfer protein clones. The predicted protein shows no significant sequence similarity to other known (phospholipid)-binding proteins. DNA blot hybridization suggests that the rat genome may contain more than one gene encoding PtdIns transfer protein. RNA blot hybridization reveals that the PtdIns transfer protein gene is expressed at low levels in a wide variety of rat tissues; all tissues examined showed a major mRNA component of 1.9 kilobases and a minor component of 3.4 kilobases. The isolation of clones encoding rat PtdIns transfer protein will greatly facilitate studies of the structure and function of PtdIns transfer proteins and their role in lipid metabolism.