cssi/SciSciGPT-SciSciNet huggingface dataset:
OPPORTUNISTIC COMPUTED TOMOGRAPHY SCREENING SHOWS A HIGH INCIDENCE OF OSTEOPOROSIS IN ANKYLOSING SPONDYLITIS PATIENTS WITH ACUTE VERTEBRAL FRACTURES

Summary Statement It is now possible to diagnose osteoporosis using incidental CT scans; this approach has been used to objectively demonstrate the role of osteoporosis in fracture in ankylosing spondylitis patients. Background In advanced disease, Ankylosing Spondylitis (AS) is frequently associated with a reduction in bone mineral density (BMD), this contributes to pain and predisposes to fractures. Quantifying this reduction in BMD is complicated by the simultaneous processes occurring, in which there is both an overgrowth of bone (syndesmophytes) and a concurrent loss of trabecular bone. Traditional methods such as dual-energy X-ray absorptiometry (DXA) struggle to generate accurate estimates for BMD in these patients. It has recently become possible to diagnose osteoporosis, with a high sensitivity and specificity, using incidental CT scans of the L1 vertebra. The purpose of this study was to evaluate the use of opportunistic CT screening in the diagnosis of osteoporosis in patients with AS who had sustained vertebral fractures. Patients & Methods Following Institutional review board approval, patients with AS who presented, with acute fractures of the spine, to our facility between 2004 and 2013 were reviewed to assess whether or not they had a Computed Tomography (CT) scan of the abdomen on admission or in the 6 months before or after injury. In addition, patients were also required to have signs of advanced AS such as the presence of syndesmophytes and syndesmophyte bridging; patients with fractures through L1 were excluded. Of those fitting the criteria, a region of Interest (ROI) was generated over the body of L1, Hounsfield unit (HU) were then measured. Results Of the 42 patients reviewed, a total of 17 AS patients fit the above criteria. 15 were male and 2 were female, mean age of the whole cohort was 69.9years (range 22–85; SD 15.9). Using a threshold balanced for sensitivity and specificity ( Discussion and Conclusion This study demonstrates, for the first time, using opportunistic CT screening, that a high proportion of AS patients who sustain fractures have osteoporosis; this overcomes the difficulties that have been encountered with the use of DXA in this unique group of patients. This simple and accessible method saves on excess cost and exposure to radiation. With a high sensitivity, patients identified using this method can then be managed more proactively. We believe these data have the potential to significantly impact the day to day management of patients with spondyloarthropathies.
A recursion on maximal chains in the Tamari lattices

The Tamari lattices have been intensely studied since their introduction by Dov Tamari around 1960. However oddly enough, a formula for the number of maximal chains is still unknown. This is due largely to the fact that maximal chains in the n th Tamari lattice T n range in length from n - 1 to n 2 . In this note, we treat vertices in the lattice as Young diagrams and identify maximal chains as certain tableaux. For each i ź - 1 , we define C i ( n ) as the set of maximal chains in T n of length n + i . We give a recursion for # C i ( n ) and an explicit formula based on predetermined initial values. The formula is a polynomial in n of degree 3 i + 3 . For example, the number of maximal chains of length n in T n is # C 0 ( n ) = n 3 . The formula has a combinatorial interpretation in terms of a special property of maximal chains.
A modeling and simulation language for biological cells with coupled mechanical and chemical processes

Biological cells are the prototypical example of active matter. Cells sense and respond to mechanical, chemical and electrical environmental stimuli with a range of mechanistic responses, including dynamic changes in morphology and mechanical properties, chemical uptake and secretion, cell differentiation, proliferation, death, and migration. Modeling and simulation of such dynamic phenomena pose a number of computational challenges. A modeling language describing cellular dynamics must naturally represent complex intra and extra-cellular spatial structures and coupled mechanical, chemical and electrical processes. A compiler must then be able to generate a computational model from this physically motivated description. Finally, a simulator must efficiently evaluate the time evolution of the computational model to generate simulation results. We present the Mechanica modeling language, compiler, and particle-based simulation engine. Mechanica enables construction and simulation of mechanistic models of natural phenomena which couple mechanical and chemical processes, using natural, physically and biologically motivated constructs.
Interfirm Relationships and Business Performance

We organized business associations for the owner-managers of randomly selected young Chinese firms to study the effect of business networks on firm performance. We randomized 2,800 firms into small groups whose managers held monthly meetings for one year, and into a “no- meetings” control group. We find that: (1) The meetings increased firm revenue by 8.1 percent, and also significantly increased profit, factors, inputs, the number of partners, borrowing, and a management score; (2) These effects persisted one year after the conclusion of the meetings; and (3) Firms randomized to have better peers exhibited higher growth. We exploit additional interventions to document concrete channels. (4) Managers shared exogenous business-relevant information, particularly when they were not competitors, showing that the meetings facilitated learning from peers. (5) Managers created more business partnerships in the regular than in other one-time meetings, showing that the meetings improved supplier-client matching. (6) Firms whose managers discussed management, partners, or finance improved more in the associated domain, suggesting that the content of conversations shaped the nature of gains.
Understanding workers, developing effective tasks, and enhancing marketplace dynamics: a study of a large crowdsourcing marketplace

We conduct an experimental analysis of a dataset comprising over 27 million microtasks performed by over 70,000 workers issued to a large crowdsourcing marketplace between 2012--2016. Using this data---never before analyzed in an academic context---we shed light on three crucial aspects of crowdsourcing: (1) Task design---helping requesters understand what constitutes an effective task, and how to go about designing one; (2) Marketplace dynamics --- helping marketplace administrators and designers understand the interaction between tasks and workers, and the corresponding marketplace load; and (3) Worker behavior --- understanding worker attention spans, lifetimes, and general behavior, for the improvement of the crowdsourcing ecosystem as a whole.
Polarization Signatures of Kink Instabilities in the Blazar Emission Region from Relativistic Magnetohydrodynamic Simulations

Kink instabilities are likely to occur in the current-carrying magnetized plasma jets. Recent observations of the blazar radiation and polarization signatures suggest that the blazar emission region may be considerably magnetized. While the kink instability has been studied with first-principle magnetohydrodynamic (MHD) simulations, the corresponding time-dependent radiation and polarization signatures have not been investigated. In this paper, we perform comprehensive polarization-dependent radiation modeling of the kink instability in the blazar emission region based on relativistic MHD (RMHD) simulations. We find that the kink instability may give rise to strong flares with polarization angle (PA) swings or weak flares with polarization fluctuations, depending on the initial magnetic topology and magnetization. These findings are consistent with observations. Compared with the shock model, the kink model generates polarization signatures that are in better agreement with the general polarization observations. Therefore, we suggest that kink instabilities may widely exist in the jet environment, and provide an efficient way to convert the magnetic energy and produce multiwavelength flares and polarization variations.
Implications of Blood Pressure Measurement Technique for Implementation of Systolic Blood Pressure Intervention Trial (SPRINT)

BackgroundCardiovascular morbidity and mortality was reduced by 25% when blood pressure (BP) was targeted to 120 mm Hg systolic compared with 140 mm Hg systolic in Systolic Blood Pressure Intervent...
Performance measurement as policy rhetoric: the case of federal arts councils

Various reforms at the federal level have led bureaucracies, including arts councils, to design and implement performance measurement systems. We still know very little about whether performance me...
Robustness and Optimality of Light Harvesting in Cyanobacterial Photosystem I

As most biological species, photosynthetic lifeforms have evolved to function optimally, despite thermal disorder and with fault tolerance. It remains a challenge to understand how this is achieved. To address this challenge, the function of the protein−pigment complex photosystem I (PSI) of the cyanobacterium Synechococcus elongatus is investigated theoretically. The recently obtained high-resolution structure of this complex exhibits an aggregate of 96 chlorophylls that are electronically coupled to function as a light-harvesting antenna complex. This paper constructs an effective Hamiltonian for the chlorophyll aggregate to describe excitation transfer dynamics and spectral properties of PSI. For this purpose, a new kinetic expansion method, the sojourn expansion, is introduced. Our study shows that at room temperature fluctuations of site energies have little effect on the calculated excitation lifetime and quantum yield, which compare favorably with experimental results. The efficiency of the system ...
Fibers of tropicalization

We use functoriality of tropicalization and the geometry of projections of subvarieties of tori to show that the fibers of the tropicalization map are dense in the Zariski topology. For subvarieties of tori over fields of generalized power series, points in each tropical fiber are obtained “constructively” using Kedlaya’s transfinite version of Newton’s method.
A Question About Differential Ideals

Abstract This paper investigates the converse to a theorem which states that a differential domain D finitely generated over a field F of characteristic 0 with no nonzero proper differential ideals will have constants of differentiation C only in the field in question. The converse is known to be false but the question of whether the differential domain D can be finitely extended within its quotient field E to a domain with no nonzero proper differential ideals was raised by Magid (Magid, A. (1991). Lectures on Differential Galois Theory. University Lecture Series, Vol. 7, Providence: AMS). Two examples are given with different properties to show that the answer is no. It is shown to be true under hypotheses which include restrictions on F and limiting the number of generators of D over C to two or the transcendence degree of D over C to one.
The Nuclear Criticality Safety Aspects of Plutonium-238

Plutonium-238 is an important heat producing isotope which is being used in increasing amounts as fuel in isotopic power generators for space, terrestrial, and oceanographic applications. Only within the past few years has the quantity of plutonium-238 become large enough to be considered as a potential nuclear criticality hazard. In order to insure nuclear criticality safety in the storage, processing and assembly of devices containing plutonium-238, a program has been established at Mound Laboratory to investigate the nuclear criticality properties of this isotope. This paper will summarize what is presently known about the criticality behavior of plutonium-238, what are some of the criticality controls used as Mound Laboratory for processing plutonium-238, and what measurements are needed in order to establish a Nuclear Safety Guide for Plutonium-238.
Theory of anomalous magnetotransport from mass anisotropy

In underdoped ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{6+x}$, there is evidence of a small Fermi surface pocket subject to substantial mass enhancement in the doping regime $0.12lpl0.16$. This mass enhancement may vary substantially over the Fermi surface, due to ``hot spot'' or other relevant physics. We therefore examine the magnetotransport of an electronlike Fermi pocket with large effective mass anisotropy. Within the relaxation time approximation, we show that even for a pocket with a fixed shape, the magnitude and sign of the Hall effect may change as the mass anisotropy changes (except at very large, likely inaccessible magnetic fields). We discuss implications for recent Hall measurements in near optimally doped cuprates in high fields. In addition we identify a novel intermediate asymptotic regime of magnetic field, characterized by B-linear magnetoresistance. Similar phenomena should occur in a variety of other experimental systems with anisotropic mass enhancement.
Functional Status, Cognition, and Social Relationships in Dyadic Perspective

OBJECTIVES Health limitations can change older adults' social relationships and social engagement. Yet, researchers rarely examine how the disability of one's spouse might affect one's social relationships, even though such life strains are often experienced as a couple. This study investigates the association between functional and cognitive limitations and social experience in a dyadic context. METHOD We use actor-partner interdependence models to analyze the partner data from 953 heterosexual couples in Wave II (2010-2011) of the National Social Life, Health, and Aging Project. RESULTS One spouse's functional and cognitive health is associated with the other's relationship quality, but the pattern varies by gender. Husbands' functional limitations are associated with lower marital support and higher marital strain in wives, but wives' functional limitations are related to lower family and friendship strain in husbands. Husbands' cognitive impairment also predicts higher family and friend support in wives. DISCUSSION Findings support a gendered dyadic relationship between health and social life and highlight women's caregiver role and better connection with family and friends. There are also differences between experiencing cognitive and physical limitations in couples. Finally, mild health impairment sometimes shows stronger effects on social relationships than severe impairment, suggesting adaptation to health transition.
Hardening Stratum, the Bitcoin Pool Mining Protocol

Stratum, the de-facto mining communication protocol used by blockchain based cryptocurrency systems, enables miners to reliably and efficiently fetch jobs from mining pool servers. In this paper we exploit Stratum's lack of encryption to develop passive and active attacks on Bitcoin's mining protocol, with important implications on the privacy, security and even safety of mining equipment owners. We introduce StraTap and ISP Log attacks, that infer miner earnings if given access to miner communications, or even their logs. We develop BiteCoin, an active attack that hijacks shares submitted by miners, and their associated payouts. We build BiteCoin on WireGhost, a tool we developed to hijack and surreptitiously maintain Stratum connections. Our attacks reveal that securing Stratum through pervasive encryption is not only undesirable (due to large overheads), but also ineffective: an adversary can predict miner earnings even when given access to only packet timestamps. Instead, we devise Bedrock, a minimalistic Stratum extension that protects the privacy and security of mining participants. We introduce and leverage the mining cookie concept, a secret that each miner shares with the pool and includes in its puzzle computations, and that prevents attackers from reconstructing or hijacking the puzzles. We have implemented our attacks and collected 138MB of Stratum protocol traffic from mining equipment in the US and Venezuela. We show that Bedrock is resilient to active attacks even when an adversary breaks the crypto constructs it uses. Bedrock imposes a daily overhead of 12.03s on a single pool server that handles mining traffic from 16,000 miners.
Measuring Global and Country-Specific Uncertainty

Abstract Motivated by the literature on the capital asset pricing model, we decompose the uncertainty of a typical forecaster into common and idiosyncratic uncertainty. Using individual survey data from the Consensus Forecasts over the period of 1989–2014, we develop monthly measures of macroeconomic uncertainty covering 45 countries and construct a measure of global uncertainty as the weighted average of country-specific uncertainties. Our measure captures perceived uncertainty of market participants and derives from two components that are shown to exhibit strikingly different behavior. Common uncertainty shocks produce the large and persistent negative response in real economic activity, whereas the contributions of idiosyncratic uncertainty shocks are negligible.
Quantum de Finetti Theorems Under Local Measurements with Applications

Quantum de Finetti theorems are a useful tool in the study of correlations in quantum multipartite states. In this paper we prove two new quantum de Finetti theorems, both showing that under tests formed by local measurements in each of the subsystems one can get an exponential improvement in the error dependence on the dimension of the subsystems. We also obtain similar results for non-signaling probability distributions. We give several applications of the results to quantum complexity theory, polynomial optimization, and quantum information theory. The proofs of the new quantum de Finetti theorems are based on information theory, in particular on the chain rule of mutual information. The results constitute improvements and generalizations of a recent de Finetti theorem due to Brandao, Christandl and Yard.
Feasibility and scalability of spring parameters in distraction enterogenesis in a murine model.

Abstract Background Distraction enterogenesis has been investigated as a novel treatment for short bowel syndrome (SBS). With variable intestinal sizes, it is critical to determine safe, translatable spring characteristics in differently sized animal models before clinical use. Nitinol springs have been shown to lengthen intestines in rats and pigs. Here, we show spring-mediated intestinal lengthening is scalable and feasible in a murine model. Materials and methods A 10-mm nitinol spring was compressed to 3 mm and placed in a 5-mm intestinal segment isolated from continuity in mice. A noncompressed spring placed in a similar fashion served as a control. Spring parameters were proportionally extrapolated from previous spring parameters to accommodate the smaller size of murine intestines. After 2-3 wk, the intestinal segments were examined for size and histology. Results Experimental group with spring constants, k = 0.2-1.4 N/m, showed intestinal lengthening from 5.0 ± 0.6 mm to 9.5 ± 0.8 mm (P Conclusions Nitinol springs with k ≤ 0.4 N/m can safely yield nearly 2-fold distraction enterogenesis in length and diameter in a scalable mouse model. Not only does this study derive the safe ranges and translatable spring characteristics in a scalable murine model for patients with short bowel syndrome, it also demonstrates the feasibility of spring-mediated intestinal lengthening in a mouse, which can be used to study underlying mechanisms in the future.
CC shadow volumes

We present a technique that uses culling and clamping (CC) for accelerating the performance of stencil-based shadow volume computation. Our algorithm reduces the fill requirements and rasterization cost of shadow volumes by reducing unnecessary rendering. A culling step removes shadow volumes that are themselves in shadow or do not contribute to thefinal image. Our novel clamping algorithms restrict shadow volumes to those regions actually containing shadow receivers. In this way, we avoid rasterizing shadow volumes over large regions of empty space. We utilize temporal coherence between successive frames to speed up clamping computations. Even with fairly coarse clamping we obtain substantial reduction in fill requirements and shadow rendering time in dynamic environments composed of up to a 100K triangles.
Prompting the Benefit of the Doubt: The Joint Effect of Auditor‐Client Social Bonds and Measurement Uncertainty on Audit Adjustments

We design an incentivized experiment to test whether measurement uncertainty elevates the risk that social bonds between auditors and reporters compromise audit adjustments. Results indicate that, when audit evidence is characterized by some residual uncertainty, the adjustments our auditor-participants require are sensitive to whether auditors have an opportunity to form a modest but friendly social bond with reporters. In contrast, although auditors do not adjust fully even when misstatements are known with certainty, social bonding has no effect in this scenario. Accordingly, our experiment contributes beyond the main effects of social bonding and measurement uncertainty demonstrated in prior research by showing that these forces interact. A practical implication is that regulators and practitioners should consider both the technical and the social challenges facing audits of complex estimates. This article is protected by copyright. All rights reserved
Cryptanalyses of Candidate Branching Program Obfuscators

We describe new cryptanalytic attacks on the candidate branching program obfuscator proposed by Garg, Gentry, Halevi, Raykova, Sahai and Waters (GGHRSW) using the GGH13 graded encoding, and its variant using the GGH15 graded encoding as specified by Gentry, Gorbunov and Halevi. All our attacks require very specific structure of the branching programs being obfuscated, which in particular must have some input-partitioning property. Common to all our attacks are techniques to extract information about the “multiplicative bundling” scalars that are used in the GGHRSW construction.
Interventional cardiology's golden age of publishing.

![Figure][1] As I complete my 10-year term as editor-in-chief of JACC: Cardiovascular Interventions , I will reflect on this period when the opportunities to publish good work rose to new heights and when that opportunity was a major factor in stimulating good work. I will also praise the
Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2.

Appropriate and sequential differentiation of keratinocytes is essential for all functions of the human epidermis. Although transcriptional regulation has proven to be important for keratinocyte differentiation, little is known about the role of translational control. A key mechanism for modulating translation is through phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2). A family of different eIF2α kinases function in the integrative stress response to inhibit general protein synthesis coincident with preferential translation of select mRNAs that participate in stress alleviation. Here we demonstrate that translational control through eIF2α phosphorylation is required for normal keratinocyte differentiation. Analyses of polysome profiles revealed that key differentiation genes, including involucrin, are bound to heavy polysomes during differentiation, despite decreased general protein synthesis. Induced eIF2α phosphorylation by the general control nonderepressible 2 (GCN2) protein kinase facilitated translational control and differentiation-specific protein expression during keratinocyte differentiation. Furthermore, loss of GCN2 thwarted translational control, normal epidermal differentiation, and differentiation gene expression in organotypic skin culture. These findings underscore a previously unknown function for GCN2 phosphorylation of eIF2α and translational control in the formation of an intact human epidermis.
Employment’s Role in Enabling and Constraining Marriage in the Middle East and North Africa

We investigate the role of employment in enabling and constraining marriage for young men and women in Egypt, Jordan, and Tunisia. Survival analysis methods for age at marriage are applied to comparable labor market panel surveys from Egypt (2012), Jordan (2010), and Tunisia (2014), which include detailed labor market histories. For men, employment and especially high-quality employment are associated with more rapid transitions to marriage. For women, past—but not contemporaneous—employment statuses are associated with more rapid transitions to marriage. After addressing endogeneity using residual-inclusion methods for the case of public sector employment (a type of high-quality employment), we find that such employment significantly accelerates marriage for men in Egypt and women in Egypt and Tunisia. The potential of high-quality employment to accelerate marriage may make queuing in unemployment while seeking high-quality employment a worthwhile strategy.
The Effects of School Reform under NCLB Waivers: Evidence from Focus Schools in Kentucky

Under waivers to the No Child Left Behind Act, the federal government required states to identify schools where targeted subgroups of students have the lowest achievement and to implement reforms i...
Representation, sophisticated voting, and the size of the gridlock region:

We propose a formal model that investigates the institutional cause of the expansion of the gridlock region in a legislative body under supermajority rule. We show that the interaction between a legislative election and the supermajority rule in the legislative policy-making process causes an expansion of the size of the gridlock region under certain circumstances. More specifically, if the position of the status quo is neither too moderate nor too extreme, then certain voters will be incentivized to elect a more extreme representative than themselves, and this sophisticated voting results in the expansion of the size of the gridlock region. As a result, our model demonstrates that the expansion of the gridlock region is caused in part by sophisticated voting independent of the voters’ ideological distribution.
Mapping the Optical Properties of SOI-type Photonic Crystal Waveguides

We report on systematic mapping of transmission properties of W1 waveguides as a function of structural parameters. We demonstrate experimentally and theoretically that the bandwidth is maximized up to 125nm by decreasing the hole radius.
Fault-Tolerance in Real-Time Systems

Abstract With ever-increasing reliance on digital computers in embedded systems such as in space, avionics, manufacturing, and life-support monitoring/control applications, the need for dependable systems that deliver services in a timely manner has become crucial. Embedded systems often interact with the external environment and operate under strict timeliness and reliability requirements. Fault tolerance and real-time requirements on a system often influence one another in subtle ways, for example, the requirements on a highly—available system, such as an air traffic control system, may derive the timing constraints imposed on certain critical tasks. In cases where a set of interacting tasks operate under strict timing constraints, missing a deadline may result in a catastrophic system failure, which was termed a dynamic failure in (Shin, Krishna, and Lee, 1985). This paper argues that fault- tolerance and real-time requirements are not orthogonal and it addresses some of the challenges that confront the designers of fault-tolerant real-time systems. These challenges include formal specification of reliability and timing requirements, appropriate language and operating system support for providing fault-tolerance in a time-critical system, new scheduling theories which consider multiple resources and fault-tolerance, tradeoff between time and space redundancy, and predictable redundancy management in the presence of faults.
A Small Adrenocortical Carcinoma With Aggressive Behavior: An Evaluation of Criteria for Malignancy

Adrenocortical carcinoma is an unusual tumor that tends to be larger than 100 g at diagnosis. Malignant adrenocortical tumors of less than 50 g have been reported rarely. We studied a small adrenocortical carcinoma that weighed 40 g and metastasized 3 1/2 years following bilateral adrenalectomy. The malignancy of adrenocortical tumors is frequently difficult to determine. Two recent studies have proposed histologic criteria for determining the malignancy of adrenal cortical tumors. Since the tumor we studied was initially judged to be benign, we sought to determine whether an extensive evaluation of this tumor using these recent criteria could have identified the tumor's potential for metastasizing. Careful application of these criteria indicated that the tumor was either a borderline lesion or a definitely malignant lesion. This emphasizes the need to approach systematically all adrenal neoplasms with regard to determining their malignant potential. Documenting small adrenocortical carcinomas also should help in setting criteria for evaluating adrenal masses discovered incidentally by sensitive radiologic methods.
The Impact of Computed Tomography Scanning on the Child With Renal Trauma

A six-year experience using computed tomography(CT) in the diagnosis of blunt abdominal trauma was reviewed to assess the impact of CT scanning on a patient with renal injury. Three questions were evaluated: (1) Does the increased sensitivity of the CT scan heter the indications for surgery? (2) Does the CT scan help predict the course and eventual outcome of nonoperative therapy? (3) Are there circumstances when the CT scan is not the most efficient and cost effective method of diagnosis? One hundred seventy six consecutive patients with suspected renal trauma were reviewed. One hundred thirty eight were evaluated by CT scan and IVP, the other 38 by exretory urogram alone. Forty four renal injuries were identified. Four of these patients required urgent surgery and four others required later operation for unsuspected congenital anomalies. The injuries sustained by the other 36 cases resolved without surgery. Each patient has been followed for 1 to 5 years following their trauma, and their status assessed by questionnaire and physical examination. The CT technique provides better definition of the injury upon which to base the decision to operate or to enter the patient into nonoperative management. The extravasation seen on CT scan is frequently exaggerated and should not be an absolute indication for exploration. The scan provides improved follow-up data as to completeness of healing and allows directions to be given to the parents concerning resumption of full physical activities. The patients with asymptomatic posttraumatic hematuria, have in our experience, a very low incidence of intraperitoneal or retroperitoneal injuries. Therefore, these patients do not require the advantages of CT scan and may be screened by the less expensive intravenous pyelogram.
Nuclear Imaging in the Pediatric Acute Scrotum

• The acute scrotum in the pediatric patient frequently presents a diagnostic dilemma for even the most experienced clinician. In an effort to improve testicular salvage in equivocal cases, immediate surgical intervention has been recommended, despite a large number of unnecessary explorations. Evaluating the sodium pertechnetate Tc 99m radioisotopic scan in 46 boys, we found this study to be a rapid, reliable, sensitive, and noninvasive test that allows the selection of those patients who require immediate surgical intervention. (Am J Dis Child1982;136:831-835)
The Role of Fibrin Adhesive in Vascular Surgery

Abstract Fibrin Seal (FS) (a natural adhesive material composed of fibrinogen, cold insoluble globulin, factor XIII, platelet growth factor, antiplasmin thrombin, and calcium chloride) was utilized in the construction of vascular anastomosis of the femoral artery of mongrel dogs. A significant decrease in the number of sutures necessary to achieve adequate anastomosis and minimize the likelihood of postoperative bleeding was noted. There was no long-term increase in tissue reaction or decrease in arterial patency. On the basis of these preliminary results the role of FS as a hemostatic agent in vascular and especially microvascular surgery warrants further investigation.
Self-Retaining Ureteral Stent Catheters in the Management of Urologic Complications of Gynecologic Malignancies

Fifteen patients with ureteral obstruction secondary to advanced and/or recurrent gynecologic malignancies underwent endoscopic (3) or surgical transvesical (12) insertion of Gibbons (12) or Double "J" (3) stent catheters. Renal function improvement was noted in all but one patient who had renal parenchymal disease. No complication attributable to the insertion procedure was recorded. This approach to the treatment of ureteral occlusion in patients with gynecologic cancer is discussed and recommended.
Proteolytic Fragmentation of Rat Prolactin by the Rat Ventral Prostate Gland

Homogenates of rat ventral prostate diminished the immunoreactivity of rat prolactin (PRL) in a fashion dependent on time and tissue concentration, suggestive of hormone degradation. Direct evidence of PRL proteolysis was demonstrated by subjecting ventral prostate homogenates and cell fractions that were incubated with 125I-labeled rat PRL to SDS-PAGE and radioautography. Heat-labile PRL proteolysis predominated in the crude homogenate, the 3,300g pellet and the 100,000g (100 K g) supernatant of rat ventral prostate. The degradation of PRL by the 100 K g supernatant led to the formation of two stable peptide fragments weighing approximately 16,000 and 12,000 daltons. PRL proteolysis was negligible in 100 K g supernatants of the liver, salivary gland, testis, epididymis, vas deferens, seminal vesicle, and dorsolateral prostates of male rats. On the other hand, 100 K g supernatants of rat spleen, lung, and kidney did degrade rat PRL, although the patterns of peptide fragment formation differed from that of ventral prostate. Enzyme inhibitor analysis suggested that PRL degradation by the 100 K g supernatants of rat ventral prostate was due to sulfhydryl and serine proteases and not due to metalloenzyme or aspartate proteases. The functional significance of PRL fragmentation by rat ventral prostate cytosol remains to be determined.
Can a Cytological Grading System be Predictive of Gleason’s Scores in Aspiration Biopsy Cytology Specimens of Prostate Carcinoma?

A perceived disadvantage of fine needle aspiration biopsy is that aspiration biopsy cytology cannot be correlated with tissue grading systems based on tissue patterns of prostate carcinoma. We feel that it is possible to predict tissue patterns of prostate carcinoma and to estimate Gleason's scores in aspiration biopsy specimens. Cytologically, prostate carcinomas may be reduced to those with glands, cribriform patterns, or undifferentiated solid or discohesive structures. Tumor grading based on patterns of prostate carcinoma may have significant impact on judging patient prognosis and on determining optimum patient therapy by allowing the urologist to apply the vast bank of existing data based on tissue studies to the interpretation of material obtained by fine needle aspiration biopsy of the prostate gland.
Examining the effect of goal clarity on faculty performance

ABSTRACTPerformance of faculty members is the prime factor in the success of any academic organisation and certainly engineering academic organisation. The performance depends on various factors. This study tests our hypothesis, in the context of an Indian engineering college, that goal clarity is one such factor that significantly impacts faculty performance. Our experiment emphasised the importance of goal clarity by screening a relevant movie and by seeking professional goals from the faculty members. After a year, we evaluated the faculty performance using peer evaluation method and triangulated the data with course evaluation by students where faculty member’s goal was to be a better teacher, to ensure the trustworthiness of peer evaluation. We found that the performance of faculty, who had goal clarity, was significantly better than the performance of those who did not have goal clarity.
A robust information source estimator with sparse observations

Purpose/Background: In this paper, we consider the problem of locating the information source with sparse observations. We assume that a piece of information spreads in a network following a heterogeneous susceptible-infected-recovered (SIR) model, where a node is said to be infected when it receives the information and recovered when it removes or hides the information. We further assume that a small subset of infected nodes are reported, from which we need to find the source of the information. Methods: We adopt the sample path-based estimator developed in the work of Zhu and Ying (arXiv:1206.5421, 2012) and prove that on infinite trees, the sample path-based estimator is a Jordan infection center with respect to the set of observed infected nodes. In other words, the sample path-based estimator minimizes the maximum distance to observed infected nodes. We further prove that the distance between the estimator and the actual source is upper bounded by a constant independent of the number of infected nodes with a high probability on infinite trees. Results: Our simulations on tree networks and real-world networks show that the sample path-based estimator is closer to the actual source than several other algorithms. Conclusions: In this paper, we proposed the sample path-based estimator for information source localization. Both theoretic analysis and numerical evaluations showed that the sample path-based estimator is robust and close to the real source.
CEMENTLESS TOTAL KNEE ARTHROPLASTY FIXATION: GETTING IT RIGHT

Cementless fixation in TKA has been inconsistently adopted since its early use but is increasing due to a number of factors, predominantly related to a demand for improved survivorship in younger patients. Modern biomaterials have demonstrated optimal bone ingrowth and have also contributed to a renewed confidence by surgeons to utilise cementless fixation in TKA. With a modern design and appropriate surgical technique, optimal mechanical stability of new designs have been demonstrated and can build upon the excellent long-term outcomes that have rivaled traditional cemented TKA. Paramount to obtaining successful long-term osseointegration and clinical survivorship with cementless fixation is an awareness of the past failure mechanisms to improve implant modern implant design, and should also guide meticulous surgical technique. A robust implant design with optimal surgical technique is critical to success when employing cementless fixation in TKA. The tried and true principles of sufficient mechanical stability to minimise micromotion of an osteoconductive implant surface with intimate contact against viable bone are essential to allow osseointegration and long-term survivorship. The surgical techniques and tips for “getting it right” include: 1.) Meticulous planar cuts - Prevention of saw blade deviation (particularly anterior femoral cortex and sclerotic medial tibial plateau), Appropriate tolerances in cutting guides (particularly 4-in-1 femoral cutting guide), Appropriate interference fit for tibial keel/stem, patella planar cut, Perfect planar cut on tibial surface confirmed with “4-corner test”. 2.) Implantation of components to maximise mechanical stability - Intimate implant contact with bone (minimizing gaps), Consider bone slurry to minimise gaps, Prevention of femoral component flexion with impaction, Ensure parallel position of tibial baseplate with tibial cut surface during impaction, Peripheral fixation on tibial baseplate, either screws or pegs, to provide supplemental fixation and stability in titanium tray designs.
A minimal RNA ligand for potent RIG-I activation in living mice

We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I receptor. When introduced into mice, a family of short, triphosphorylated stem-loop RNAs (SLRs) induces a potent interferon response and the activation of specific genes essential for antiviral defense. Using RNA sequencing, we provide the first in vivo genome-wide view of the expression networks that are initiated upon RIG-I activation. We observe that SLRs specifically induce type I interferons, subsets of interferon-stimulated genes (ISGs), and cellular remodeling factors. By contrast, polyinosinic:polycytidylic acid [poly(I:C)], which binds and activates multiple RNA sensors, induces type III interferons and several unique ISGs. The short length (10 to 14 base pairs) and robust function of SLRs in mice demonstrate that RIG-I forms active signaling complexes without oligomerizing on RNA. These findings demonstrate that SLRs are potent therapeutic and investigative tools for targeted modulation of the innate immune system.
Spin-memory loss due to spin-orbit coupling at ferromagnet/heavy-metal interfaces: Ab initio spin-density matrix approach

Spin-memory loss (SML) of electrons traversing ferromagnetic-metal/heavy-metal (FM/HM), FM/normal-metal (FM/NM), and HM/NM interfaces is a fundamental phenomenon that must be invoked to explain consistently large numbers of spintronic experiments. However, its strength extracted by fitting experimental data to phenomenological semiclassical theory, which replaces each interface by a fictitious bulk diffusive layer, is poorly understood from a microscopic quantum framework and/or materials properties. Here we describe an ensemble of flowing spin quantum states using spin-density matrix, so that SML is measured like any decoherence process by the decay of its off-diagonal elements or, equivalently, by the reduction of the magnitude of polarization vector. By combining this framework with density functional theory, we examine how all three components of the polarization vector change at Co/Ta, Co/Pt, Co/Cu, Pt/Cu, and Pt/Au interfaces embedded within Cu/FM/HM/Cu vertical heterostructures. In addition, we use ab initio Green's functions to compute spectral functions and spin textures over FM, HM, and NM monolayers around these interfaces which quantify interfacial spin-orbit coupling and explain the microscopic origin of SML in long-standing puzzles, such as why it is nonzero at the Co/Cu interface; why it is very large at the Pt/Cu interface; and why it occurs even in the absence of disorder, intermixing and magnons at the interface.
Swine Leukocyte Antigen Class II Is a Xenoantigen.

Background Over 130 000 patients in the United States alone need a lifesaving organ transplant. Genetically modified porcine organs could resolve the donor organ shortage, but human xenoreactive antibodies destroy pig cells and are the major barrier to clinical application of xenotransplantation. The objective of this study was to determine whether waitlisted patients possess preformed antibodies to swine leukocyte antigen (SLA) class II, homologs of the class II HLA. Methods Sera from people currently awaiting solid organ transplant were tested for IgG binding to class II SLA proteins when expressed on mammalian cells. Pig fibroblasts were made positive by transfection with the class II transactivator. As a second expression system, transgenes encoding the alpha and beta chains of class II SLA were transfected into human embryonic kidney cells. Results Human sera containing IgG specific for class II HLA molecules exhibited greater binding to class II SLA positive cells than to SLA negative cells. Sera lacking antibodies against class II HLA showed no change in binding regardless of the presence of class II SLA. These antibodies could recognize either SLA-DR or SLA-DQ complexes. Conclusions Class II SLA proteins may behave as xenoantigens for people with humoral immunity toward class II HLA molecules.
Vaccine waning and mumps re-emergence in the United States

After decades of declining mumps incidence amid widespread vaccination, the United States and other developed countries have experienced a resurgence in mumps cases over the last decade. Outbreaks affecting vaccinated individuals and communities with high vaccine coverage have prompted concerns about the effectiveness of the live attenuated vaccine currently in use. It is unclear whether immune protection wanes or whether the vaccine protects inadequately against currently circulating mumps virus lineages. Synthesizing data from six studies of mumps vaccine effectiveness, we estimated that vaccine-derived immune protection against mumps wanes on average 27 years (95% confidence interval, 16 to 51 years) after vaccination. After accounting for this waning, we found no evidence that the emergence of heterologous virus genotypes contributed to changes in vaccine effectiveness over time. A mathematical model of mumps transmission confirmed the central role of waning immunity to the vaccine in the re-emergence of mumps cases. Outbreaks from 2006 to the present among young adults, and outbreaks in the late 1980s and early 1990s among adolescents, aligned with peaks in mumps susceptibility of these age groups predicted to be due to loss of vaccine-derived protection. In contrast, evolution of mumps virus strains escaping immune pressure would be expected to cause a higher proportion of cases among children, not adolescents and young adults as observed. Routine use of a third vaccine dose at 18 years of age, or booster dosing throughout adulthood, may be a strategy to prevent mumps re-emergence and should be assessed in clinical trials.
Quantifying the Pressure of Legal Risks on Third-party Vulnerability Research

Product vendors and vulnerability researchers work with the same underlying artifacts, but can be motivated by goals that are distinct and, at times, disjoint. This potential for conflict, coupled with the legal instruments available to product vendors (e.g., EULAs, DMCA, CFAA, etc.) drive a broad concern that there are "chilling effects" that dissuade vulnerability researchers from vigorously evaluating product security. Indeed, there are well-known examples of legal action taken against individual researchers. However, these are inherently anecdotal in nature and skeptics of the chilling-effects hypothesis argue that there is no systematic evidence to justify such concerns. This paper is motivated by precisely this tussle. We present some of the first work to address this issue on a quantitative and empirical footing, illuminating the sentiments of both product vendors and vulnerability researchers. First, we canvas a range of product companies for explicit permission to conduct security assessments and thus characterize the degree to which the broad software vendor community is supportive of vulnerability research activities and how this varies based on the nature of the researcher. Second, we conduct an online sentiment survey of vulnerability researchers to understand the extent to which they have abstract concerns or concrete experience with legal threats and the extent to which this mindset shapes their choices.
A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases

Asparagine-linked (N-linked) protein glycosylation is one of the most abundant types of posttranslational modification, occurring in all domains of life. The central enzyme in N-linked glycosylation is the oligosaccharyltransferase (OST), which catalyzes the covalent attachment of preassembled glycans to specific asparagine residues in target proteins. Whereas in higher eukaryotes the OST is comprised of eight different membrane proteins, of which the catalytic subunit is STT3, in kinetoplastids and prokaryotes the OST is a monomeric enzyme bearing homology to STT3. Given their relative simplicity, these single-subunit OSTs (ssOSTs) have emerged as important targets for mechanistic dissection of poorly understood aspects of N-glycosylation and at the same time hold great potential for the biosynthesis of custom glycoproteins. To take advantage of this utility, this chapter describes a multipronged approach for studying and engineering ssOSTs that integrates in vivo screening technology with in vitro characterization methods, thereby creating a versatile and readily adaptable pipeline for virtually any ssOST of interest.