cssi/SciSciGPT-SciSciNet huggingface dataset:
“Sorcellerie évocatoire”: Magic and Memory in Baudelaire and Eliphas Lévi

The relationship between Charles Baudelaire and his contemporary, the occult writer Eliphas Levi, has long interested scholars. This essay argues that instead of fruitlessly looking for evidence of direct literary influence between the two men, we should look on their writings as parallel texts exploring remarkably similar themes but to radically different ends. Both Levi and Baudelaire wrote about the supposed mystical origins of language and were interested in the links between poetry and black magic—a means, in both cases, to conjure up past experiences or absent people. Baudelaire's poem “Un Fantome” also explores the connection between memory and the occult concept of “lumiere astrale,” the mystical, unifying force that supposedly penetrated and connected all Creation. Although Baudelaire's writing looked to such occult ideas as potential antidotes to the fragmentation and transience of existence, he saw that they were ultimately marked by a fatal and quintessentially modern irony: Although ideas aki...
Cancer Centers—Origins and Purpose: The James Ewing Lecture

• Cancer centers in the United States date back to the beginning of this century, although there were few until the late 1950s and 1960s. The National Cancer Act of 1971 introduced a new era in serving as a major stimulus to the development of comprehensive cancer centers. Research scientists and physicians in centers have contributed significantly to the new knowledge of normal and abnormal regulation of cell growth and differentiation and to the advances in the diagnosis and treatment of cancer. The future for cancer centers is very bright. They will continue to play a major role in the advancement of knowledge about cancer. However, centers must be reevaluated at intervals to correct any deficiencies and to stimulate new and innovative approaches. Surgical oncologists should become more involved in cancer center research. Comprehensive cancer centers should develop more effective regional cancer control and prevention programs. Reevaluation of centers by the National Cancer Institute, Bethesda, Md, and its advisory body, the National Cancer Advisory Board, along with cancer center leaders, should result in a consensus concerning changes to enhance their contribution to a solution to the cancer problem. ( Arch Surg 1989;124:43-45)
Physics-Based Modeling and Control of Residual-Affected HCCI Engines

Homogeneous charge compression ignition (HCCI) is a novel combustion strategy for IC engines that exhibits dramatic decreases in fuel consumption and exhaust emissions. Originally conceived in 1979, the HCCI methodology has been revisited several times by industry but has yet to be implemented because the process is difficult to control. To help address these control challenges, the authors here outline the first generalizable, validated, and experimentally implemented physics-based control methodology for residual-affected HCCI engines. Specifically, the paper describes the formulation and validation of a two-input, two-state control-oriented system model of the residual-affected HCCI process occurring in a single engine cylinder. The combustion timing and peak pressure are the model states, while the inducted gas composition and effective compression ratio are the model inputs. The resulting model accurately captures the system dynamics and allows the simultaneous, coordinated control of both in-cylinder pressure and combustion timing. To demonstrate this, an H 2 optimal controller is synthesized from a linearized version of the model and used to dictate step changes in both combustion timing and peak pressure within about four to five engine cycles on an experimental test bed. The application of control also results in reductions in the standard deviation for both combustion timing and peak pressure. The approach therefore provides accurate mean tracking, as well as a reduction in cyclic dispersion. Another benefit of the simultaneous coordination of both control inputs is a reduction in the control effort required to elicit the desired response. Instead of using a peak pressure controller that must compensate for the effects of a combustion timing controller, and vice versa, the coordinated approach optimizes the use of both control inputs to regulate both outputs.
Doing the Right Thing: Ethical Leadership and Decision Making

This chapter explores the relationship between leadership style, ethical orientation, and the AACC competencies. A glimpse of the competencies in practices is provided through the results of interviews with thirteen community college presidents. The findings presented here are culled from a larger study of presidential decision making during difficult times (Garza Mitchell and Hornak, 2010; Hornak and Garza Mitchell, 2010) that was funded by a Faculty Research and Creative Endeavors grant from Central Michigan University.
Influence of Electrofishing on the Mortality of Arctic Grayling Eggs

Abstract The influence of electrofishing on egg mortality of Arctic grayling Thymallus arcticus was investigated. The hypothesis that electrofishing affects egg mortality was supported by two experiments. Experiment 1 examined the mortality rate of Arctic grayling eggs from parents that were electroshocked before spawning, and experiment 2 examined mortality rates of eggs that were electroshocked after fertilization. For experiment 1, egg mortality rates were significantly higher than the control group. The difference in mean mortality rates was 0.016 (SE = 0.005) compared to the control (P = 0.022). For experiment 2, mean egg mortality varied significantly (P < 0.001) by parents (electroshocked or not electroshocked), level of electroshock, and egg developmental stage. The largest difference in mean mortality rates compared with that of controls was 0.086 (SE = 0.017) for eggs electroshocked at the highest voltage gradient (1.30–1.50 V/cm), at 70 temperature units postfertilization, and from parents that...
Hamiltonian cycles in cayley color graphs

A group Γ is said to possess a hamiltonian generating set if there exists a minimal generating set Δ for Γ such that the Cayley color graph DΔ(Γ) is hamiltonian. It is shown that every finite abelian group has a hamiltonian generating set. Certain classes of nonabelian groups are also investigated.
Causal Connections, Universals, and Russell's Hypothetico-Scientific Realism

L'A. defend le realisme hypothetico-scientifique de Russell inspire de la distinction kantienne entre phenomene et noumene, et affirmant l'existence de connexions causales entre les universaux, contre l'objection du mathematicien M. Newman reprise par W. Demopoulos et M. Friedman, qui ignore le role critique des universaux entendus dans le sens anti-realiste d'extensions, et non de proprietes et de relations
Polymorphism of nickel-phosphorus metallic glasses

It is shown that nickel-phosphorus metallic glass alloys not only exhibit two distinct local structural configurations for a given composition, but also that the configuration can be selected by choosing the appropriate processing parameters. It is also shown that the structure exhibiting the greater Knight shift exhibits a discontinuous transformation to the structure with the lower Knight shift. Measurements have been extended to amorphous alloys containing up to 42 at.% phosphorus.
Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA

Thienylpyrimidines substituted at position 2 of the pyrimidine with a chiral aminoalkoxy group were synthesized. Upon interaction with duplex DNA, the unfused heteroaromatic system of these compounds intercalates with DNA base pairs and the protonated side chain is located in the major groove. The S-enantiomers bind more strongly than their R-counterparts with enantiomeric discrimination, as measured by a ratio of binding constants K(S)/K(R), ranging from 1.2 to 2.4.
Reduction of Listeria monocytogenes in cold-smoked salmon by bacteriophage P100, nisin and lauric arginate, singly or in combinations

Summary Three GRAS antimicrobials including, lauric arginate (LAE), bacteriophage P100 (phage P100) and bacteriocin nisin, were evaluated either singly or in combinations for the reduction of initial load of Listeria monocytogenes in cold-smoked salmon (CSS). The stability of phage P100 in the presence of LAE (200 ppm) and nisin (500 ppm) or at 10× and 100× of these concentrations was determined at 4 °C or 30 °C for 24 h in a broth model. Phage P100 was found to be highly stable in the presence of these antimicrobial agents as plaque-forming units (PFU) did not vary between control and antimicrobial-treated phage. The survival of L. monocytogenes in the presence of phage P100, nisin and LAE showed remarkable reduction within 24 h both at 4 °C or 30 °C in broth. Treatment of CSS containing 3.5 log CFU cm−2 L. monocytogenes with phage P100 (108 PFU mL−1), nisin (500 ppm) and LAE (200 ppm) showed strong listericidal action and reduced the L. monocytogenes by 2–3 log CFU cm−2 after 24 h. Among the combined treatments, phage P100 + LAE or nisin + LAE exhibited the most listericidal action in which L. monocytogenes cells were reduced to undetectable level within 24 h in CSS.
Increased nerve growth factor receptor mRNA in contused rat spinal cord

Peripheral nerve injury induces the expression of nerve growth factor receptor (NGFR). To determine whether a similar induction results from injury of the spinal cord, NGFR mRNA content was determined using Northern blot hybridization analysis of total RNA from spinal cords of rats contused in the mid-thoracic region. By four days after contusion NGFR mRNA was significantly increased in the thoracic segments that included the injury site. The induction was maximal at 7 days, about 5- to 7-fold the level of uninjured controls, and remained 4 times higher than controls at 14 and 28 days after injury. These results suggest that axotomy in the CNS may also trigger the molecular mechanism(s) leading to up-regulation of NGFR expression.
Breath acidification in adolescent runners exposed to atmospheric pollution: A prospective, repeated measures observational study

Vigorous outdoors exercise during an episode of air pollution might cause airway inflammation. The purpose of this study was to examine the effects of vigorous outdoor exercise during peak smog season on breath pH, a biomarker of airway inflammation, in adolescent athletes. We measured breath pH both pre- and post-exercise on ten days during peak smog season in 16 high school athletes engaged in daily long-distance running in a downwind suburb of Atlanta. The association of post-exercise breath pH with ambient ozone and particulate matter concentrations was tested with linear regression. We collected 144 pre-exercise and 146 post-exercise breath samples from 16 runners (mean age 14.9 years, 56% male). Median pre-exercise breath pH was 7.58 (interquartile range: 6.90 to 7.86) and did not change significantly after exercise. We observed no significant association between ambient ozone or particulate matter and post-exercise breath pH. However both pre- and post-exercise breath pH were strikingly low in these athletes when compared to a control sample of 14 relatively sedentary healthy adults and to published values of breath pH in healthy subjects. Although we did not observe an acute effect of air pollution exposure during exercise on breath pH, breath pH was surprisingly low in this sample of otherwise healthy long-distance runners. We speculate that repetitive vigorous exercise may induce airway acidification.
ISOLATION AND IDENTIFICATION OF THE LONG-ACTING THYROID STIMULATOR AND ITS RELATION TO HYPERTHYROIDISM AND CIRCUMSCRIBED PRETIBIAL MYXEDEMA.

Long-acting thyroid stimulator (LATS) was found in the plasma in each of 7 subjects with circumscribed, pretibial myxedema, which in every instance had developed after surgical or radioiodine treatment of thyrotoxicosis. Using a potent plasma from one of these subjects, a bio-assay method for the quantitative measurement of LATS was developed which was used in subsequent fractionation and recovery experiments. By fractional precipitation of the proteins of LATS plasma by acid potassium phosphate, followed by gel filtration of the active fraction through diethylaminoethyl-Sephadex, LATS was eluted with a single protein moiety and was recovered in 60–80% yield with an 8-fold increase in purity. Analysis by the methods of ultracentrifugation, paper electrophoresis, immunoelectrophoresis, double diffusion in agar, and sucrose gradient separation confirmed the presence of a single protein which was identified as a 7S gamma globulin. Incubation of LATS with antihuman-7S antibody or digestion of LATS by papain d...
Anwendung eines hochfrequenten Hämmerverfahrens zur Optimierung von geschweißten Motorbauteilen bei MAN Diesel SE

Das hochfrequente Hammerverfahren HiFIT (high frequency impact treatment) zur Lebensdauerverlangerung bestehender und neuer Stahlschweiskonstruktionen konnte bei MAN Diesel SE erfolgreich eingefuhrt werden. Ein wesentlicher Arbeitsschritt war dabei die Entwicklung eines neuartigen Bemessungskonzeptes auf Basis bruchmechanischer Methoden. Zum einen wurde das Nachbehandlungsverfahren in der Neukonstruktion einer Olwanne eingesetzt, um die notigen Sicherheitsfaktoren gegen Dauerbruch darstellen zu konnen. Zum anderen wurde es nachtraglich eingefuhrt, nachdem durch Spannungsmessungen an einem Fundamentrahmen die Notwendigkeit einer Verbesserung deutlich wurde. Die Anwendungsbeispiele werden im folgenden Beitrag vorgestellt. In beiden Fallen wurde durch das hochfrequente Hammerverfahren die Dauerfestigkeit erreicht und durch Betriebserfahrung bestatigt. Damit konnte ein weiterer Schritt in Richtung eines betriebssicheren Leichtbaus von Schweiskonstruktionen erfolgreich gegangen werden. Implementation of high-frequent hammer-peening as an optimisation step for welded engine components at MAN Diesel SE. The high-frequent hammer-peening called HiFIT (high frequency impact treatment) was introduced successfully at MAN Diesel SE. As an essential step, a new fatigue assessment procedure based on fracture mechanics was developed. On one hand, the after-treatment procedure was used in the design phase of an oil pan to achieve sufficient safety factors against fatigue fracture. On the other hand, it was adopted in an existing design of a foundation frame because in-situ measurements have revealed the need for improvement. This paper represents the both examples of application. In both cases, the fatigue requirements have been fulfilled with the high-frequent hammer-peening and are approved by field-experience. Thus, another step towards a reliable light-weight-design of welded components could be taken
Superconductive energy storage inductor-converter units for power systems

Large magnets with superconductive windings could serve to perform a power system function analogous to pumped storage hydro. A conventional Graetz bridge converter as used in dc transmission provides an ideal interface between the three-phase power system and the superconductive magnet or inductor. Such Inductor-Converter or I-C units, when properly controlled, provide significant power system benefits. Power reversibility is achievable within a few cycles without switching. Power system electromechanical oscillations can be damped effectively. Computer studies reveal that this damping capability may be useful even with smaller inductor sizes when energy storage in large amounts is not the primary objective. In sizes greater than 1,000 MWh, economic studies show promise.
Limit states design considerations for gusset plates

Abstract In spite of the extensive use of gusset plates as connecting elements in a variety of structures over the years, current design criteria are essentially based on very limited research work, and primarily of elastic analytical background. For example, North American design practice uses the results of the elastic model studies of Whitmore, obtained through research that was completed in 1952. With these things in mind, the paper discusses the design considerations that must be made when designing for ultimate strength, specifically, utilizing the limit states design formulation. Thus, limit states design models are described for tension and compression applications of gusset plates, although it is noted that much more research is needed before the criteria for compression can be considered as complete. Of particular interest are the second-order deformation effects in gusset plates; these are recent findings in experimental studies. It is demonstrated how load application and direction as well as type and orientation of the boundary connections have a major influence on the strength and behavior of these plates. A final summary itemizes the design checks that should be made.
Pallidotomy improves motor responses and widens the levodopa therapeutic window in Parkinson's disease.

Stereotactic posteroventral pallidotomy (PVP) as a treatment for Parkinson's disease (PD) symptoms has been increasingly used in moderate-advanced disease. We examined the pharmacodynamic responses of PD patients to single oral levodopa doses and intravenous levodopa infusions before and after PVP surgery. Nine subjects with advanced PD received a single oral dose and ramped intravenous levodopa infusions before and 3-5 weeks after unilateral PVP. Timed motor tasks, Unified Parkinson's Disease Rating Scale (UPDRS) evaluations, and ordinal dyskinesia rating were performed after oral levodopa and during i.v. levodopa infusions. Serum prolactin and dopa levels were measured during the levodopa infusions. Overall timed motor but not motor UPDRS scores were improved after PVP in both the worst ("off") and best ("on") states. Contralateral but not ipsilateral limb dyskinesias were substantially reduced at all serum (dopa) levels after PVP. Ipsilateral and contralateral timed motor performance at low serum (dopa) levels was improved by PVP. Walking speeds at all serum (dopa) levels were not changed by PVP. Serum prolactin was reduced equally by increasing (dopa) preoperatively and postoperatively. PVP significantly and favorably altered oral and intravenous levodopa pharmacodynamics by improving bilateral limb motor function and contralateral dyskinesia but did not alter walking speed. PVP appears to widen significantly the therapeutic window for levodopa in PD.
Application of molecular marker analysis to reconcile sources of carbonaceous particulates in tropospheric aerosols

Abstract Carbonaceous particulates in aerosols are derived from two major sources and are admixed depending on the geographic area. These sources are biogenic detritus (eg. pollen, microbes, etc.) and anthropogenic emissions (eg. soot, charcoal, etc.). Both biogenic detritus and some of the anthropogenic emissions contain organic materials (C 14 –C 40+ ) extractable by solvents, which have unique and distinguishable compound distribution patterns. Molecular marker analysis has been applied to such extracts after suitable chemical separation into subfractions. Microbial and vascular plant lipids are the dominant biogenic residues and petroleum hydrocarbons, with lesser amounts of the pyrogenic polynuclear aromatic hydrocarbons, are the major anthropogenic residues. The sources of these compound classes can be reconciled by the applications of the same analytical techniques to composited vegetation samples and emissions from vehicles (both gasoline and diesel) and fires. This approach is of utility in tracing air parcels from particular geographic regions and as tags for vehicular emissions.
The Replication Intermediates in Escherichia coli Are Not the Product of DNA Processing or Uracil Excision

The current model of DNA replication in Escherichia coli postulates continuous synthesis of the leading strand, based on in vitro experiments with purified enzymes. In contrast, in vivo experiments in E. coli and its bacteriophages, in which maturation of replication intermediates was blocked, report discontinuous DNA synthesis of both the lagging and the leading strands. To address this discrepancy, we analyzed nascent DNA species from ThyA+ E. coli cells replicating their DNA in ligase-deficient conditions to block maturation of replication intermediates. We report here that the bulk of the newly synthesized DNA isolated from ligase-deficient cells have a length between 0.3 and 3 kb, with a minor fraction being longer that 11 kb but shorter than the chromosome. The low molecular weight of the replication intermediates is unchanged by blocking linear DNA processing with a recBCD mutation or by blocking uracil excision with an ung mutation. These results are consistent with the previously proposed discontinuous replication of the leading strand in E. coli.
Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity

MDCK cells expressing RhoA or Rac1 mutants under control of the tetracycline repressible transactivator were used to examine short-term effects of known amounts of each mutant before, during, or after development of cell polarity. At low cell density, Rac1V12 cells had a flattened morphology and intact cell–cell contacts, whereas Rac1N17 cells were tightly compacted. Abnormal intracellular aggregates formed between Rac1N17, F-actin, and E-cadherin in these nonpolarized cells. At all subsequent stages of polarity development, Rac1N17 and Rac1V12 colocalized with E-cadherin and F-actin in an unusual beaded pattern at lateral membranes. In polarized cells, intracellular aggregates formed with Rac1V12, F-actin, and an apical membrane protein (GP135). At low cell density, RhoAV14 and RhoAN19 were localized in the cytoplasm, and cells were generally flattened and more fibroblastic than epithelial in morphology. In polarized RhoAV14 cells, F-actin was diffuse at lateral membranes and prominent in stress fibers on the basal membrane. GP135 was abnormally localized to the lateral membrane and in intracellular aggregates, but E-cadherin distribution appeared normal. In RhoAN19 cells, F-actin, E-cadherin, and GP135 distributions were similar to those in controls. Expression of either RhoAV14 or RhoAN19 in Rac1V12 cells disrupted Rac1V12 distribution and caused cells to adopt the more fibroblastic, RhoA mutant phenotype. We suggest that Rac1 and RhoA are involved in the transition of epithelial cells from a fibroblastic to a polarized structure and function by direct and indirect regulation of actin and actin-associated membrane protein organizations.
Causes and Consequences of Blue-Green Algal (Cyanobacterial) Blooms

ABSTRACT In lakes and reservoirs, productivity and biomass responses to nutrient loading are fairly predictable; resultant changes in phytoplankton taxonomic composition are not. Whether enrichment leads to dominance by procaryotic or by eucaryotic phytoplankton is important to lake trophic structures, to ecosystem modelers, and to lake managers. Much of the uncertainty about the effects of enrichment on phytoplankton composition stems from an inadequate understanding of how nuisance bloom-formers succeed in dominating plankton assemblages. The authors contend that investigations of nutrient effects on cyanobacterial buoyancy regulation provide a basis for understanding patterns of cyanobacterial dominance during the course of eutrophication as well as during seasonal successions in stratified, eutrophic lakes. Cyanobacterial dominance in the surface layers of enriched lakes should be more pronounced in HCO3-rich waters where synthesis of the cellular components involved in buoyancy regulation is not limi...
Towards bandwidth-efficient keyword continuous query processing over DHTs

In this paper, we focus our studies on a distributed keyword continuous query processing system that is built on distributed hash tables. Treating bandwidth as a first-class resource, we propose novel query indexing algorithms including MHI and SAP-MHI, multicast-based document announcement, and adaptive query resolution to reduce bandwidth cost. Our detailed simulations show that our proposed techniques, combined together, effectively and greatly cut down bandwidth consumption.
Corrigendum to “Traumatic brain injury-induced expression and phosphorylation of pyruvate dehydrogenase: A mechanism of dysregulated glucose metabolism” [Neurosci. Lett. 454 (2009) 38–42]

Corrigendum Corrigendum to “Traumatic brain injury-induced expression and phosphorylation of pyruvate dehydrogenase: A mechanism of dysregulated glucose metabolism” [Neurosci. Lett. 454 (2009) 38–42] Guoqiang Xing a,∗,1, Ming Ren b,1, William D. Watson b, J. Timothy O’Neill c, Ajay Verma b a Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States b Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, United States c Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, United States
Inhibition of brain dopamine-β-hydroxylase activity by methimazole

Abstract Rat brain dopamine-β-hydroxylase (DβH) activity was estimated using graded doses of 3 H-dopamine injected intracistermally. Animals treated acutely with methimazole, 5 to 50 mg/kg (.044 to .44 millimole/kg), displayed a dose-related decrease in the levels of 3 H-norepinephrine formed from 3 H-dopamine. The ID 50 of methimazole was 10 mg/kg (.088 millimole/kg). The duration of DβH inhibition, which was accompanied by a decrease in endogenous norepinephrine concentration, was between 6 and 12 hours following a single acute 10 mg/kg dose of methimazole. Methimazole's effect on DβH is thought to be mediated via its ability to chelate copper.
Acute abdominal pain: Is there a potential role for MRI in the setting of the emergency department in a patient with renal calculi?

Acute flank pain is a frequent clinical presentation encountered in emergency departments, and a work-up for obstructive urolithiasis in this setting is a common indication for computed tomography (CT). However, imaging alternatives to CT for the evaluation of renal colic are warranted in some clinical situations, such as younger patients, pregnancy, patients that have undergone multiple prior CT exams and also patients with vague clinical presentations. MRI, although relatively insensitive for the direct detection of urinary calculi, has the ability to detect the secondary effects of obstructive urolithiasis. Using rapid, single shot T2-weighted sequences without and with fat saturation provides an abdominopelvic MR examination that can detect the sequelae of clinically active stone disease, in addition to alternate inflammatory processes that may mimic the symptoms of renal colic. In addition, MR nephro-urography (MRNU) has the ability to provide quantitative analysis of renal function that has the potential to direct clinical management in the setting of obstructing calculi. This review describes the potential utility and limitations of MRI in the emergency setting for diagnosing causes of flank pain and renal colic, particularly in patients with unusual presentations or when an alternative to CT may be warranted. J. Magn. Reson. Imaging 2010;32:1012–1023. © 2010 Wiley-Liss, Inc.
Lifetime abuse and self-harm in people with severe mental illness: a structural equation model

We tested the hypothesis that lifetime physical and sexual abuse would have direct effects on self-harm (i.e., thoughts of self-harm, self-harming behaviors, and suicide attempts) and indirect effects on self-harm via negative appraisals of trauma and psychiatric symptoms in a sample of 242 clients with severe mental illness (SMI). Structural equation modeling partly confirmed our expectations. Although there was no direct effect between abuse and self-harm, abuse and self-harm appear to be fully mediated by negative appraisal and psychiatric symptoms. Limitations to this study include the cross-sectional nature of the research, which precludes firm causal inferences regarding the relationships among these factors. Longitudinal designs are needed to understand better the direct and indirect effects of abuse on people with SMI. (PsycINFO Database Record Language: en
Clinicopathologic features and treatment strategies for patients with pancreatic adenocarcinoma and ovarian metastases.

Abstract Background. Ovarian metastases from pancreatic adenocarcinoma are uncommon and data on the clinical features, treatment, and survival of patients with pancreatic adenocarcinoma with ovarian metastases is limited. The purpose of this study is to define the clinical characteristics and treatment strategies for this patient population. Methods. We reviewed the charts of 18 patients with pancreatic adenocarcinoma with ovarian metastasis who had presented to The University of Texas M. D. Anderson Cancer Center from 1985 to 2005. Results. Of the 18 patients diagnosed with pancreatic adenocarcinoma and ovarian metastases, 8 (44%) presented with ovarian metastases initially and a pancreatic primary tumor became apparent only on further imaging or during surgery. On pathology review, the primary pancreatic cancers (5 out of 18) and ovarian metastases (8 out of 16) showed mucinous characteristics. Patients who underwent resection of their ovarian metastases followed by chemotherapy had a trend of longer median survival compared to patients who received chemotherapy alone without resection of the ovarian metastases (16.5 vs. 8.5 months, respectively; p =0.28). Patients who responded to chemotherapy had a trend of longer survival compared to nonresponders (19 vs. 6 months, respectively; p =0.1). No responses were observed in the ovarian metastases to chemotherapy alone. Conclusions. Primary pancreatic adenocarcinoma with synchronous ovarian metastases may present initially as symptomatic ovarian masses and they commonly have mucinous histologic characteristics. Surgical resection of ovarian metastases may play an important palliative role in the treatment of symptomatic patients with good performance status and lead to longer survival.
Pulsed Laser Deposition of Barium Zirconate Thin Films for Neutral Imaging Applications

Low work function surfaces offer great promise as thermionic converters and neutral conversion surfaces due to the relative ease with which electrons may be removed. BaZrO3 surfaces were prepared using pulsed laser deposition (PLD) and their materials properties evaluated for potential use as a neutral conversion surface for space applications. Single layer films were fabricated at temperatures ranging from 110°C to 600°C, and as a function of background ambient pressure. The degree of crystallinity of the resulting films was measured using x-ray diffraction (XRD) and the surface morphology evaluated with atomic force microscopy (AFM). The film quality was found to be directly related to substrate temperature: an increase in grain size from ~ 10 nm to >50 nm and improved crystal orientation with respect to the substrate were observed as the deposition temperature was increased from 110°C to 600°C.
Realizing quantum controlled phase-flip gate through quantum dot in silicon photonic crystal waveguide

Scheme to realize controlled phase gate through single quantum dot in slow-light silicon photonic crystal waveguide is proposed. Enhanced Purcell factor and beta-factor lead to high gate fidelity over broadband frequencies compared to cavity-assisted system.
Demographic and lifestyle factors associated with perceived stress in the primary care setting: a MetroNet study.

Background. Stress and stress-related disorders are common in primary care. The stress-related needs for patients are often unmet partially due to the time and resource constraints inherent to many primary care settings. We examined the relative significance of key demographic and lifestyle factors related to stress among primary care patients. This information is unknown and needed to strategize these increasingly limited resources. Methods. We distributed surveys to 100 consecutive adult patients in each of four family medicine centres in metropolitan Detroit between 2006 and 2007. Hierarchical multivariable regression analyses were used to assess the relative significance of the demographic and lifestyle factors related to stress. Results. Of the 400 distributed surveys, 315 (78.7%) answered a minimum of 70% of the questions and were included in the analysis. The lifestyle factors [exercise, body mass index (BMI), sleep, social support, recovery or self-care skills (such as the ability to rest, relax and recuperate)] explained 39% (P < 0.001) of the variance in stress compared to 10% (P < 0.001) by the demographic factors (age, gender, race, employment, education and marital status). Stress was inversely related to sleep (P < 0.001), recovery (P < 0.001) and social support (P = 0.02) and positively to education (P < 0.001). Conclusions. The modifiable lifestyle factors explained significantly more of perceived stress among primary care patients than the demographic factors. Sleep and recovery had the biggest inverse relationship with stress, which suggests that they should be the primary target for assessment and intervention in patients who report stress or stress-related disorders.
Drug-involved Mexican-origin girls’ HIV prevention needs: A pilot study

The purpose of this pilot study was to collect data to inform the development of an HIV prevention program for drug-involved Mexican-origin (MO) adolescent girls. Eighteen in-depth semi-structured interviews were conducted with drug-involved MO girls in addition to focus group discussions with nineteen other drug-involved MO girls and eight clinical service providers in 2009-2010. Emergent themes indicated that HIV prevention programs for drug-involved MO girls should be girl-centered, focused on relationship development, and include trained peer facilitators who share the same cultural and "street" background as the girls. The program should omit scare tactics associated with risky sexual behaviors and emphasize individual empowerment skills useful to negotiate sexual decisions successfully. In addition, a girl-centered intervention for MO girls should address important concerns for this group, including resistance skills and strategies regarding relationships with older men, teenage motherhood, sexual infidelity, sexual coercion, and dating violence. Intervention activities should also be interactive with an emphasis on guiding girls as they learn to critically assess personal risk while at the same time learning skills and resources to address these issues in real life.
Insulin Stimulates the Phosphorylation and Activity of Farnesyltransferase via the Ras-Mitogen-Activated Protein Kinase Pathway

Farnesylation of p21Ras by farnesyltransferase (FTase) is obligatory for anchoring p21Ras to the plasma membrane, where it can be activated by growth factors. Insulin significantly stimulates the phosphorylation of the α-subunit of FTase (4-fold) and the enzymatic activity of FTase in 3T3-L1 fibroblasts and adipocytes. FTase activity was assessed by the amount of [3H] mevalonate (a precursor of farnesyl) incorporated into p21Ras in vivo and by quantitating the amount of farnesylated p21Ras before and after insulin administration. Insulin-stimulated phosphorylation of the α-subunit of FTase in 3T3-L1 fibroblasts and adipocytes was blocked by the mitogen-activated protein/extracellular-signal regulated kinase-kinase inhibitor, PD98059, but not by wortmannin or bisindolylmaleimide. Additionally, PD98059 blocked insulin-stimulated[ 3H]mevalonic incorporation and farnesylation of unprocessed p21Ras in both cell lines. Furthermore, expression of the dominant negative mutant of p21Ras precluded insulin-stimulate...
Using physics-based modeler outputs to train probabilistic neural networks for unexploded ordnance (UXO) classification in magnetometry surveys

The outputs from a physics-based modeler of magnetometry data have been successfully used with a probabilistic neural network (PNN) to discriminate unexploded ordnance (UXO) from ordnance-related scrap. Cross-validation predictions were performed on three data sets to determine which modeler parameters were most valuable for UXO classification. The best performing parameter combination consisted of the modeler outputs depth, size, and inclination. The cross-validation results also indicated that good prediction performance could be expected. Model outputs from one location at a site were used to train a PNN model, which could correctly discriminate UXO from scrap at a different location of the same site. In addition, data from one site, the former Buckley Field, Arapahoe County, CO, was used to predict targets detected at an entirely different training range. The Badlands Bombing Range, Bull's Eye 2 (BBR 2), Cuny Table, SD. Through careful selection of the probability threshold cutoff, the UXO detection rate obtained was 95% with a false alarm rate of only 37%. The ability to distinguish individual UXO types has been demonstrated with correct classifications between 71% and 95%.
Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs

Advanced maternal age is unequivocally associated with increased aneuploidy in human eggs and infertility, but the molecular basis for this phenomenon is unknown. An age-dependent deterioration of the spindle assembly checkpoint (SAC) has been proposed as a probable cause of aneuploidy. Accurate chromosome segregation depends on correct chromosome attachment to spindle microtubules, and the SAC provides time for this process by delaying anaphase onset until all chromosomes are stably attached. If SAC function decreases with age, oocytes from reproductively old mice would enter anaphase of meiosis I (AI) prematurely, leading to chromosome segregation errors and aneuploid eggs. Although intuitively appealing, this hypothesis is largely untested. We used a natural reproductive aging mouse model to determine if a defective SAC is the primary cause of aneuploidy in eggs. We tracked the progress of individual oocytes from young and old mice through meiosis I by time-lapse microscopy and counted chromosomes in the resulting eggs. This data set allowed us to correlate the timing of AI onset with aneuploidy in individual oocytes. We found that oocytes from old mice do not enter AI prematurely compared to young counterparts despite a 4-fold increase in the incidence of aneuploidy. Moreover, we did not observe a correlation between the timing of AI onset and aneuploidy in individual oocytes. When SAC function was challenged with a low concentration of the spindle toxin nocodazole, oocytes from both young and old mice arrested at meiosis I, which is indicative of a functional checkpoint. These findings indicate that a defective SAC is unlikely the primary cause of aneuploidy associated with maternal age.
The clinical significance of resistant uropathogens in ambulatory urinary tract infections in women.

Sir, I read with interest the article by Dr. Eva Hummers-Pradier et al., regarding treating ambulatory urinary tract infections (UTIs) in women [1]. The authors should be complimented on such a wel...
Struggling with the Past

Many postprocessual archaeologists have argued that active individuals make history. The apotheosis of the individual has been achieved under the rubric “identity,” the most pervasive theoretical term of the last few years. This focus obscures the fundamental idea that individuals do not exist in isolation. The relational concept of struggle will help us past this theoretical impasse. This concept has many components including real struggles in the past, our struggles to know the past, and using the past to struggle in the present. Our goal is to “struggle past” identity politics and the individual by focusing on peoples' real struggles in real cases.
Fatty acid composition ofcuphea seed oils

Nineteen species of 10 taxonomic sections ofCuphea were analyzed for fatty acid composition of the seed oils. Two sections of the genus,Trispermum andPseudocircaea, previously unreported, are included. Lauric acid is the major component of the seed oil in seven of the species surveyed; capric andmyristic each predominate in five. Linolenic acid, previously thought to be only a trace component ofCuphea seed oils, is the major constituent of two species. Two others are rich in linoleic acid, another minor component of mostCupbea oils.
Microarray analysis in prostate cancer research.

Purpose of review Microarray technologies are now being used to analyse prostate tumors and to gain insights into prostate cancer biology. This review provides a background on microarray technology, reviews recent applications of these techniques in prostate cancer research, and discusses the potential application of this technology to patient care. Recent findings An analysis of genome-wide changes in expression has identified several hundred genes differentially expressed by normal and malignant prostate tissues. Some, such as hepsin, not only show increased expression in cancer, but can also provide prognostic information on prostate tumors based on their level of expression. Microarrays have also been used to characterize gene expression changes associated with androgen stimulation, the activation of EGR1 pathways, and prostate epithelial cellular senescence. Summary Microarray analysis of gene expression in prostate cancer is in its infancy. Future work will probably yield new diagnostic and prognostic markers, provide insight into prostate cancer biology, and aid in identifying new therapeutic strategies.
The Isoperimetric Quotient: Another Look at an Old Favorite

(1991). The Isoperimetric Quotient: Another Look at an Old Favorite. The College Mathematics Journal: Vol. 22, No. 4, pp. 313-315.
Excess Vacancy Generation by Silicide Formation in Si

It has been long recognized that excess point defects are generated when a metal silicide is formed on silicon. Since the common dopants diffuse in Si with the aid of both self-interstials and vacancies, these point defect perturbations will influence motion of diffusions that are in the adjacent vicinity. TiSi 2 is known to enhance the concentration of vacancies and several mechanisms have been proposed for this effect. Recent literature has dealt with and rejected many of these ideas; however, some of the remaining few like film strain and lattice contraction upon silicidation have been the subject of state of the art experiments which has led to their rejection. It is the contention of this paper that by using the experimental data from this recent work and reinterpreting it, the model of volume contraction of the silicides as the cause for vacancy injection, still represents the most physically satisfying cause and therefore, was mistakenly rejected.
Frequency Studies and Scaling Effects of Jet Interaction in a Feedback-Free Fluidic Oscillator

The work presented in this paper focuses on understanding the effects of scaling on fluidic oscillator performance, with a particular emphasis on the relationship between flow rate and oscillation frequency. The jet interaction feedback-free type of fluidic oscillator used in this investigation is a strong candidate for a flow control actuator, as it has high bandwidth, no moving parts, and high momentum capability. The aim of this study is to understand the basic fluid dynamics of fluidic oscillators, as well as to provide an engineering database of information for future oscillator designs. Results presented in this paper detail the frequency response of the fluidic oscillator under various geometric and supply fluid conditions. Scaling studies were performed in order to establish the operating range of the device. Oscillators were built and tested with different fluids in gas and liquid phases over a range of magnitude in flow rate and frequency response. Frequency maps of the oscillator response indicate a flow field that is rich in high-frequency content, with up to the 7 th harmonic visible in the spectra. Three different flow regimes were observed with particle image velocimetry with a refractive index matched fluid. An interesting modehopping behavior was also observed which varied with the size of the oscillator, aspect ratio, and test fluid.
A New Genus and Species of Blind Sleeper (Teleostei: Eleotridae) from Oaxaca, Mexico: First Obligate Cave Gobiiform in the Western Hemisphere

Caecieleotris morrisi, new genus and species of sleeper (family Eleotridae), is described from a submerged freshwater cave in a karst region of the northern portion of the State of Oaxaca, Mexico, Rio Papaloapan drainage, Gulf of Mexico basin. The new species represents the first cave-adapted sleeper known from the Western Hemisphere and is one of only 13 stygobitic gobiiforms known worldwide, with all others limited in distribution to the Indo-Pacific region. The new taxon represents a third independent evolution of a hypogean lifestyle in sleepers, the others being two species of Oxyeleotris (O. caeca and O. colasi) from New Guinea and a single species, Bostrychus microphthalmus, from Sulawesi. Caecieleotris morrisi, new species, is distinguished from epigean eleotrids of the Western Atlantic in lacking functional eyes and body pigmentation, as well as having other troglomorphic features. It shares convergent aspects of morphology with cave-dwelling species of Oxyeleotris and B. microphthalmus but diffe...
Future Depends on Public Recognition Health Planning in Delaware

Abstract Delaware is the second smallest state in area. Our population is 550,000-366,000 in the metropolitan area. We are a high-average income state, making our areas of poverty more acute. Industry is varied from a large chemical complex accounting for $200 million to $700 million from auto, rubber, leather. Our farm population is balanced and our farm income mainly broiler chickens-accounts for an additional $130 million.
Incidental Spontaneous Coronary Artery Dissection

Spontaneous coronary artery dissection (SCAD) is a rare diagnosis that presents both a diagnostic and therapeutic challenge. This disorder is rare but more often found in young and pregnant females. The diagnosis of SCAD is difficult as the presenting signs and symptoms may be non-specific. The treatment for SCAD may often be conservative if the patient does not have acute coronary syndrome. Patients who experience dissection are at risk for future events. We present a case of a 44-year-old male with a history of smoking and hypertension who presented with chest pain and syncope. He was found on angiogram to have an SCAD. J Med Cases. 2017;8(2):36-38 doi: https://doi.org/10.14740/jmc2722w
Radiometric Evidence for the Origin of Eugeosynclinal Materials

Thorium and uranium contents of eugeosynclinal graywackes and associated volcanic rocks are similar and are in the range of 1-2 ppm thorium and 0.5-1 ppm uranium. These values are much lower than average concentrations in the continental crust and apparently indicate derivation of orogenic material directly from the upper mantle without contribution for the craton.
Hyper-spectral communications, networking & ATM as foundation for safe and efficient future flight: Transcending aviation operational limitations with diverse and secure multi-band, multi-mode, and mmWave wireless links: Project overview, aviation communications and new signaling

NASA's Aeronautics Research Mission Directorate (ARMD) has recently solicited proposals and awarded funds for research and development to achieve and exceed the goals envisioned in the ARMD Strategic Implementation Plan (SIP). The Hyper-Spectral Communications and Networking for Air Traffic Management (ATM) (HSCNA) project is the only University Leadership Initiative (ULI) program to address communications and networking (and to a degree, navigation and surveillance). This paper will provide an overview of the HSCNA project, and specifically describe two of the project's technical challenges: comprehensive aviation communications and networking assessment, and proposed multi-band and multi-mode communications and networking. The primary goals will be described, as will be research and development aimed to achieve and exceed these goals. Some example initial results are also provided.