cssi/SciSciGPT-SciSciNet huggingface dataset:
Interpersonal Anticipatory Synchronization: The Facilitating Role of Short Visual-Motor Feedback Delays.

Effective interpersonal coordination is fundamental to robust social interaction, and the ability to anticipate a co-actor’s behavior is essential for achieving this coordination. However, coordination research has focused on the behavioral synchrony that occurs between the simple periodic movements of co-actors and, thus, little is known about the anticipation that occurs during complex, everyday interaction. Research on the dynamics of coupled neurons, human motor control, electrical circuits, and laser semiconductors universally demonstrates that small temporal feedback delays are necessary for the anticipation of chaotic events. We therefore investigated whether similar feedback delays would promote anticipatory behavior during social interaction. Results revealed that co-actors were not only able to anticipate others’ chaotic movements when experiencing small perceptual-motor delays, but also exhibited movement patterns of equivalent complexity. This suggests that such delays, including those within the human nervous system, may enhance, rather than hinder, the anticipatory processes that underlie successful social interaction.
Adenosine kinase of sarcoma 180 cells N 6 -substituted adenosines as substrates and inhibitors.

Adenosine kinase (ATP:adenosine 59-phosphotransferase, EC 2.7.1.20) was partially purified by DEAE-cellulose column chromatography from Sarcoma 180 cells grown in vitro. This enzyme preparation, which was free of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) but contained adenylate kinase (ATP:AMP phosphotransferase, EC 2.7.4.3), was studied with respect to its kinetic properties and specificity for substrates and inhibitors. At pH 7.0 and 35° the Km for adenosine was 0.5 µM and the Vmax was 63 mµmoles/mg of protein per minute. Strong substrate inhibition was observed at adenosine concentrations greater than 4 µM, 50% inhibition occurring at about 100 µM. The reaction required ATP (Km = 200 µM) and Mg++. The optimal Mg++ concentrations were 0.1 and 0.25 mM at 0.5 and 2.5 mM ATP, respectively. Concentrations of Mg++ higher than these were inhibitory, and Mn++ substituted poorly for Mg++. Most of the N6-substituted adenosine analogues which were substrates of adenosine kinase inhibited the growth of S-180 cells in vitro. Among these were two compounds which are also known to be potent cytokinins in plant systems, namely, N6-furfuryl- and N6-(Δ2-isopentenyl)adenosine. The 59-monophosphate of the latter compound was not phosphorylated further by adenylate kinase. The N6-substituted adenosines which were poorly or not at all phosphorylated by adenosine kinase were also poor inhibitors of S-180 cells in vitro. Several of these were potent inhibitors of the kinase, such as N6-phenyladenosine, which had a Ki value of 0.6 µM.
An Integrated Approach to the Use of Information in Marketing Decision Making

In this paper we present a holistic approach to the use of information in managerial decision making. It is argued that information obtained from market research, sales forecasting and the marketing information system should be used in a more integrative manner by managers in formulating and implementing stronger marketing programs. Towards this end, an integrated approach to the use of information is developed, and its application illustrated by a case study.
Ultrasonic Guided Waves in Solid Media: Circumferential Guided Waves

Introduction In this chapter the governing equations for circumferential SH waves and circumferential Lamb type waves are developed. For brevity, circumferential SH and Lamb type waves will be abbreviated as CSH-waves and CLT-waves, respectively, from this point onward. Following the development of the single-layer cases, considerations will be made for n -layer annuli. More details on this practical problem can be found in Appendix D, Section 2.11. Circumferential guided waves are guided waves that propagate in the circumferential direction of a hollow cylinder. They have many practical applications, including the detection of corrosion in piping from in-pipe or in-line inspection (ILI) vehicles. While researchers often use plate-wave solutions to study circumferentially propagating guided waves, this chapter shows that the two cases are quite different, both physically and mathematically, and that significant differences often exist between the plate-wave and circumferential-wave solutions to the governing wave equations. The case in which the two solutions are similar is also discussed in this chapter. The amount of work published in the area of circumferential guided waves is relatively terse when compared to the body of work relating to wave propagation in the axial direction of hollow cylinders. The treatment of wave propagation in cylindrical layers is first seen in Viktorov (1967). In his text, Viktorov identifies the major physical differences between wave propagation in cylindrical structures and planar structures and specifically addresses the topics of Rayleigh waves on concave and convex surfaces and Lamb type waves in cylindrical layers. He defines the concept of angular wavenumber, which is a physical phenomenon unique to cylindrically curved waveguides. In his treatment of Lamb type waves in a cylindrical layer, Viktorov forms the characteristic equation for an elastic single layer. Because of the limited computational abilities of the time, Viktorov makes several simplifications to arrive at a first approximation.
Evaluation of CO2 Storage Mechanisms in CO2 Enhanced Oil Recovery Sites: Application to Morrow Sandstone Reservoir

This article presents numerical simulations of CO2 storage mechanisms in the Pennsylvanian Upper Morrow sandstone reservoir, locally termed the Morrow B sandstone in the Farnsworth Unit (FWU) of Ochiltree County, Texas. The CO2 storage mechanisms considered in the study under a CO2 enhanced oil recovery (EOR) mode include structural-stratigraphic trapping, CO2 dissolution in formation water and oil, and residual trapping. The reservoir simulation model was constructed on the basis of field geophysical, geological, and engineering data such as three-dimensional surface seismic data, well logs, and fluid analysis. A representative fluid sampled from the reservoir was analyzed and used to tune the equation of state. A thermodynamic minimum miscible pressure was subsequently computed and compared to the experimental outcome. A history-matched model was constructed and used as a baseline to determine the effects of different hypothetical injection strategies (that consider CO2 purchase, gas recycling, and infi...
The hemicellulose preparation, Natramune (PDS-2865), increases macrophage phagocytosis and nitric oxide production and increases circulating human lymphocytes levels.

Background Hemicellulose containing nutritional supplements demonstrate benefits to the immune system in vitro and in vivo. Here we show that Natramune (PDS-2865) stimulates phagocytosis, nitric oxide production and boosts viability in J774A.1 murine machrophages. We also show that dietary supplementation with Natramune (PDS-2865) significantly increases the levels of circulating lymphocytes in human subjects. Material/methods In order to measure the beneficial effects of Natramune (PDS-2865) on cells of the immune system, phagocytosis was measured by J774A.1 uptake of fluorescently labeled E. Coli bioparticles, nitric oxide production was measured by the formation of nitrite, and cell proliferation and viability was measured by NADH reduction of WST-8. The effect of Natramune (PDS-2865) on human circulating leukocyte levels was measured in 18 volunteers after an 8 week regimen of two 250 mg doses daily after which blood was collected and blood cell number and types were counted. Results Natramune (PDS-2865) stimulated phagocytosis, nitric oxide production and promoted proliferation/viability in J774A.1 cells by 65%, 517%, and 155% respectively. Further, Natramune (PDS-2865) did boost human circulating total lymphocyte levels (18%) in a statistically significant manner and while all lymphocyte subtype levels also increased, the individual subtype increases were not statistically significant. Conclusions Dietary supplementation with Natramune (PDS-2865) enhances immune system function and vitality.
Sensitivity to Audiovisual Temporal Asynchrony in Children With a History of Specific Language Impairment and Their Peers With Typical Development: A Replication and Follow-Up Study.

Purpose Earlier, my colleagues and I showed that children with a history of specific language impairment (H-SLI) are significantly less able to detect audiovisual asynchrony compared with children ...
Add-On Antihypertensive Medications to Angiotensin-Aldosterone System Blockers in Diabetes: A Comparative Effectiveness Study.

Background and objectives In individuals with diabetes, the comparative effectiveness of add-on antihypertensive medications added to an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker on the risk of significant kidney events is unknown. Design, setting participants, & measurements We used an observational, multicenter cohort of 21,897 individuals with diabetes to compare individuals who added β-blockers, dihydropyridine calcium channel blockers, loop diuretics, or thiazide diuretics to angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. We examined the hazard of significant kidney events, cardiovascular events, and death using Cox proportional hazard models with propensity score weighting. The composite significant kidney event end point was defined as the first occurrence of a ≥30% decline in eGFR to an eGFR Results Over a maximum of 5 years, there were 4707 significant kidney events, 1498 deaths, and 818 cardiovascular events. Compared with thiazide diuretics, hazard ratios for significant kidney events for β-blockers, calcium channel blockers, and loop diuretics were 0.81 (95% confidence interval, 0.74 to 0.89), 0.67 (95% confidence interval, 0.58 to 0.78), and 1.19 (95% confidence interval, 1.00 to 1.41), respectively. Compared with thiazide diuretics, hazard ratios of mortality for β-blockers, calcium channel blockers, and loop diuretics were 1.19 (95% confidence interval, 0.97 to 1.44), 0.73 (95% confidence interval, 0.52 to 1.03), and 1.67 (95% confidence interval, 1.31 to 2.13), respectively. Compared with thiazide diuretics, hazard ratios of cardiovascular events for β-blockers, calcium channel blockers, and loop diuretics compared with thiazide diuretics were 1.65 (95% confidence interval, 1.39 to 1.96), 1.05 (95% confidence interval, 0.80 to 1.39), and 1.55 (95% confidence interval, 1.05 to 2.27), respectively. Conclusions Compared with thiazide diuretics, calcium channel blockers were associated with a lower risk of significant kidney events and a similar risk of cardiovascular events. Podcast This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_03_23_CJASNPodcast_18_5_S.mp3
Taphonomy and negative results: An integrated approach to ceramic-bound protein residue analysis

Abstract Despite the growing body of evidence demonstrating that proteins can survive for thousands to even millions of years in selected contexts, there are relatively few examples of the successful recovery and identification of archaeological protein residues from ceramic artifacts. Claims of positive results are sometimes contentious and frequently challenged. One source of confusion in the debate is a general lack of consideration for the taphonomic histories of ceramic-bound proteins. To gain insight into this issue, we conducted an integrated, mass spectrometry-based study examining ceramic-bound protein that was experimentally aged over the course of 12 months. Results demonstrate the rapid degradation of proteins, raise questions about the degree to which ceramic-bound proteins can be expected to survive over time, and reveal some of the limitations of non-targeted mass spectrometry-based analyses. Further, by comparing results from our experimentally-aged samples to the those we obtained from a multi-pronged study of archaeological ceramics from the American Southwest, we are able to draw more confident conclusions regarding our lack of meaningful matches in the archaeological samples.
Myocardial perfusion and viability by positron emission tomography in infants and children with coronary abnormalities: correlation with echocardiography,coronary angiography, and histopathology

AbstractObjectives: This study was designed to assess the feasibility and accuracy of positron emission tomography (PET) imaging in infants and children.Background: Positron emission tomography is ...
Special Problems in the Critically Ill Trauma Patient

Identify the etiologies of traumatic shock. Describe the compensatory mechanisms in shock. Describe the measures for determining the adequacy of resuscitation during traumatic shock. Define the global and regional endpoints of resuscitation in trauma. Appreciate the utilization of trauma damage control. Discuss abdominal compartment syndrome and its pathophysiology. Appreciate the significance of the early recognition of limb compartment syndrome. Discuss the various complications associated with massive blood products transfusion in the trauma patient. Discuss the importance of recognizing and treating inhalation thermal burns and toxic inhalation injuries. Recognize carbon monoxide toxicity and institute proper treatment. Recognize the importance of venous thromboemolism as a complication in the trauma patient.
What Next for European Power Utilities

The European electricity sector has experienced significant consolidation over the last 10 years, but the era of mega-mergers is coming to an end. This chapter explores the main industry drivers behind the next wave of acquisitions, the implications for the super-utilities and the opportunities and challenges created. Unlike the consolidations of the past decade, the transactions over the next 10 years are likely to be shaped by rising oil prices, increasing environmental awareness, an increasing focus on unbundling of tariffs and ultimately assets, the emergence of financial asset owners and increasing nationalisation. The chapter explores how each of these factors poses challenges but also creates opportunities that will shape the strategies of all super-utilities in Europe.
For Crying Out Loud—The Differences Persist into the '90s

The relation of gender to crying was investigated over a 15-year interval. The 1996 sample was composed of 523 undergraduates (293 females and 230 males). Forty percent of the sample described themselves as Asian, 32% Anglo, 19% Hispanic, and 7% African American. There were extreme similarities between the 1981 and 1996 samples in terms of reported frequency and intensity of crying and the gender patterning of crying behavior across stimulus situations. In the later sample, gender role orientation (as measured by the BSRI) was found to be associated with crying. Neither ethnicity nor socioeconomic status was significantly related to any of the variables examined. It may be that crying has not been significantly affected by changing gender role expectations in the last 15 years.
Exon Skipping of FcεRIβ for Allergic Diseases

Mast cells are key effector cells in allergic inflammation and consequently are ideal targets for new therapeutics. The high-affinity IgE receptor complex, FceRI, plays a critical role in mast cell and basophil activation by allergens to drive the immediate allergic inflammatory response. The β subunit of FceRI is critical for trafficking the FceRI complex to the cell membrane and amplifies the FceRI signaling cascade. We have utilized splice switching antisense oligonucleotides to force expression of a truncated isoform of FceRIβ, which we have shown does not associate with the FceRI complex. This approach eliminates surface FceRI expression in mast cells by targeting protein-protein interactions. Exon skipping has several therapeutic applications, and our findings demonstrate a novel application to alter receptor trafficking and dampen allergic inflammation. Here, we describe the methods of exon skipping in mast cells and the assays used to examine the responses of mast cells in vitro and in vivo.
194 ADHERENCE TO PHYSICAL ACTIVITY GUIDELINES IN PEOPLE WITH MULTIPLE SCLEROSIS.

Objective Physical inactivity has increasingly been reported as a risk factor associated with an array of morbidities. Despite this evidence, nearly 70% of adults in the United States remain sedentary by the Centers for Disease Control (CDC) and the American College of Sports Medicine9s (ACSM) standards for physical activity. This study sought to determine the proportion of persons with multiple sclerosis (MS) who meet the CDC/ACSM guidelines for physical activity and examine variables that may be related to meeting these guidelines. Methods Subjects were 236 persons with MS living in the Seattle area. A research assistant asked subjects over the telephone for the frequency, duration, and type of exercise performed in the last month and basic demographic and medical history data. Respondents were classified as adherent to the CDC/ACSM guidelines if they engaged in moderate-intensity physical activity at least 5 days per week for 30 minutes or vigorous activity at least 3 days per week for 20 minutes. Results Eighty-seven percent of the sample did not meet the CDC/ACSM guidelines for regular exercise and 29% had not exercised at all in the preceding month. Chi-square analysis did not reveal any significant relationships between meeting the exercise guidelines and sex, type of MS, being ambulatory, extreme heat sensitivity, or balance problems. Body mass index values were significantly lower for those who met the exercise guidelines (mean 26.7 [SD 5.9]) than for those who did not (24.3 [SD 2.9]) (Student9s t-test, p = .038). Conclusions These findings highlight the clinical importance of encouraging increased participation in physical activity for people with MS and developing exercise interventions that are feasible for people in this population.
Investigations into the acoustics of the mandolin

The mandolin is a descendent of the lute with a long history starting in 18th century Italy. This talk will give a brief history of the mandolin culminating in the modern flat-back mandolins used in bluegrass music. After a summary of previous research into its acoustics, we will describe our current research. This includes the use of Electronic Speckle Pattern Interferomentry (ESPI) to study the low-modes of the front and back plates and studies of the driving point impedance at the bridge. The mandolin has four courses of doubled strings tuned in unison. Inspired by Weinreich’s seminal study of piano strings, we explore the coupling of the strings’ motions to each other through their attachment to the vibrating bridge. By using a macro lens on a high-speed camera, we are able to study these motions in exquisite detail. We observe clear evidence of coupling including the exchange of energy between the vertical and horizontal motions of each string and correlations in the phases of their motions. We interpret the experimental results in the context of a theoretical model. [Work supported by the National Science Foundation under Grant No. 1707978.]The mandolin is a descendent of the lute with a long history starting in 18th century Italy. This talk will give a brief history of the mandolin culminating in the modern flat-back mandolins used in bluegrass music. After a summary of previous research into its acoustics, we will describe our current research. This includes the use of Electronic Speckle Pattern Interferomentry (ESPI) to study the low-modes of the front and back plates and studies of the driving point impedance at the bridge. The mandolin has four courses of doubled strings tuned in unison. Inspired by Weinreich’s seminal study of piano strings, we explore the coupling of the strings’ motions to each other through their attachment to the vibrating bridge. By using a macro lens on a high-speed camera, we are able to study these motions in exquisite detail. We observe clear evidence of coupling including the exchange of energy between the vertical and horizontal motions of each string and correlations in the phases of their motions. We inter...
A Makerspace for Life Support Systems in Space

Human space exploration and settlement will require leaps forward in life support for environmental management and healthcare. Life support systems must efficiently use nonrenewable resources packed from Earth while increasingly relying on resources available locally in space. On-demand production of components and materials (e.g., 3D printing and synthetic biology) holds promise to satisfy the evolving set of supplies necessary to outfit human missions to space. We consider here life support systems for missions planned in the 2020s, and discuss how the maker and 'do-it-yourself' (DIY) biology communities can develop rapid, on-demand manufacturing techniques and platforms to address these needs. This Opinion invites the diverse maker community into building the next generation of flight hardware for near-term space exploration.
Developable mechanisms on regular cylindrical surfaces

Abstract Developable mechanisms can provide high functionality and compact stowability. This paper presents engineering models to aid in the design of cylindrical developable mechanisms. These models take into account the added spatial restrictions imposed by the developable surface. Equations are provided for the kinematic analysis of cylindrical developable mechanisms. A new classification for developable mechanisms is also presented (intramobile, extramobile, and transmobile) and two graphical methods are provided for determining this classification for single-DOF planar cylindrical developable mechanisms. Characteristics specific to four-bar cylindrical developable mechanisms are also discussed.
Mapping the Research Domain Criteria Social Processes Constructs to the Social Responsiveness Scale.

Objective Research Domain Criteria (RDoC) operationalizes a set of basic social dimensions that can be used to deconstruct sources of variation in social impairments across affected individuals, regardless of their diagnostic status. This is a necessary step toward the development of etiologically based and individualized treatments. The main objective of this investigation was to derive estimations of the RDoC social constructs from the Social Responsiveness Scale (SRS-2). Method Exploratory structural equation modeling and confirmatory factor analysis were conducted using individual SRS-2 items from six distinct databases ( N = 27,953; mean age = 9.55 years, SD = 3.79; 71.7% male participants) spanning normative (33.8%) and atypical (66.2%) development. The following models were estimated: a one-factor model; a three-factor model with separate attachment and affiliation, social communication, and understanding of mental states factors; and a four-factor model where social communication was further split into production of facial and non-facial communication. Results The one-factor solution showed poor fit. The three-factor solution had adequate fit (comparative fit index = 0.952, Tucker Lewis Index = 0.937, root mean square error of approximation = 0.054). However, the four-factor solution had superior fit (comparative fit index = 0.973, Tucker Lewis Index = 0.961, root mean square error of approximation = 0.042) and was robust across age, sex, and clinical status. Conclusion To our knowledge, this is the first study examining estimations of the RDoC social constructs from an existing measure. Reported findings show promise for capturing important RDoC social constructs using the SRS-2 and highlight crucial areas for the development of novel dimensional social processing measures.
Strict Performativity and the Limits of Resignification in Stories and Novels

This chapter provides close reading of a number of Elizabeth Gaskell’s short stories, which illustrate the gloomy side of Judith Butler’s theory of performativity. In these stories, which are rarely examined by literary critics, characters are compelled by discourses rather than able to manipulate or resignify them. The analysis then moves to the opposite type of text, novels that contain characters who are capable of resignifying the compulsory discourses that surround them. The focus of this section of the chapter is on Wives and Daughters, with some attention also to North and South. Mary Barton is discussed as a bridging text between Gaskell’s early short fiction and later novels. The strongest argument for the cheerful hypothesis of performativity is to be found in Gaskell’s novels, but it is not clear from them which factors make it possible for discourse to be resignified.
Ictal multicomponent agraphia in left temporal lobe epilepsy.

A 58-year-old woman with a clinical diagnosis of temporal lobe epilepsy characterized by episodes of disorientation and derealization followed by aphasia tried to write sentences during a seizure. Instead, she drew random figures (figure 1) . External standard MRI was reported normal; however, a nonenhancing left amygdala lesion was identified on our 3T epilepsy protocol MRI (figure 2) . This drawing emphasizes ictal multicomponent agraphia characterized by impaired allographic storage with expected accompanying aphasia.1 Although symbolic graphic language is impaired, non-language-based symbolic graphic production remains intact. This suggests posterior temporal/temporo-parietal junction involvement during seizure spread.2
“In the Beginning, It Was Little Whispers...Now, We’re Almost a Roar”: Conceptualizing a Model for Community and Self in LGBTQ+ Health Information Practices

Although LGBTQ+ populations experience significant health challenges, little research exists that investigates their health from an informational perspective. Our study addresses this gap by exploring the health information practices of LGBTQ+ communities in South Carolina, focusing on how sociocultural context shapes these practices. Thirty semi-structured interviews with South Carolina LGBTQ+ community leaders analyzed using open qualitative coding informed the development of a conceptual framework describing their information practices. Findings show that participants engaged in two broad types of practices – protective and defensive – as responses to risks and barriers experienced, which are in turn produced by social and structural factors. Findings advance information practices and marginalization approaches and offer ways for medical professionals to improve service to LGBTQ+ populations.
Concomitant transcarotid artery revascularization and transcatheter aortic valve replacement

Abstract Concomitant carotid artery disease and aortic valve disease is common. Whereas carotid stenosis does not appear to have an effect on outcomes of patients undergoing aortic valve replacement, the management of a patient with symptomatic carotid disease and severe aortic stenosis is challenging. The advent of minimally invasive endovascular techniques has provided less invasive and effective treatment options for these respective conditions. In this report, we describe two cases of patients successfully treated with concomitant transcatheter aortic valve replacement and transcarotid artery revascularization.
Does the Addition of Breast MRI Add Value to the Diagnostic Workup of Invasive Lobular Carcinoma

Abstract Background Invasive lobular carcinoma (ILC) has unique histologic growth pattern. Few studies have focused on the value of breast magnetic resonance imaging (MRI) specifically for ILC. We hypothesized that MRI adds value to the diagnostic workup in ILC by better defining the extent of disease and identifying additional foci of malignancy, which can change the surgical plan. Materials and methods This was a single-institution retrospective review of women diagnosed with ILC from 1/2012 to 7/2019 who underwent preoperative MRI. Patient, tumor characteristics, and initial surgical plan were reviewed. MRI had added value if ILC size correlated best to final pathologic size or if additional malignancy was identified. MRI was considered harmful if additional biopsies were benign or if the size was overestimated. Results ILC was identified in 166 breasts in 165 women. Original surgical plan was for lumpectomy in 86 (52%), mastectomy in 49 (30%), and undecided in 31 (18%). MRI changed the plan in 25 (19%) with 24 (96%) changing from lumpectomy to mastectomy. Additional biopsy was performed in 28% after MRI, the majority (n = 41, 72%) were benign or high risk and 16 (28%) identified additional malignancy. MRI was not a better size estimate than mammogram/ultrasound. Re-excision rate after lumpectomy was 6.8% (5/73). MRI added value in 48 (28.9%) and was harmful in 48 (28.9%). Conclusions Using breast MRI in the diagnostic workup of ILC has both positive and negative implications on surgical treatment planning. A shared decision-making conversation is warranted before proceeding with MRI to maximize value and minimize harms associated with this diagnostic tool.
Stability Issues for Dark Energy

Cosmological data reveal a dark energy with a negative equation of state w=P/ρ 0 to Λ=0 in an assumed first-order phase transition. From arguments about stimulated nucleation it is shown that the critical nucleation radius must be at least of galactic size. The spontaneous nucleation rate is infinitesimal thus explaining the dark energy's extreme stability. Dark energy detection at subgalactic scales will never be possible.
After Five Years: Adverse Childhood Experiences and Response to Surviving Illness Contribute to Shorter Life Expectancy

Initial research in 2012 described the psychological responses of 32 older adult survivors of critical illness. At the five year follow up in 2017, 15 participants were deceased. Only 2 of these 15...
What's Water Got to Do with It? Place-Related Symbolic Meanings Alter Residents' Perceived Effects of Coastal Infrastructure

The symbolic meanings residents associate with their local bodies of water and coastal infrastructure can shape their perceptions of the infrastructure's effects. In this case, we conduct a survey ...
Palliative Care Training for Geriatric Psychiatry Fellows: A National Survey Project.

Abstract Objectives Palliative care is an essential part of the standard of care for individuals with serious medical illnesses. Integration of palliative care and mental health is important for elderly patients with medical and psychiatric comorbidities. Geriatric psychiatrists are natural stewards of palliative care-mental health integration, however this is contingent on palliative care training. Currently, palliative care training in geriatric psychiatry fellowship programs is uncharacterized. We surveyed geriatric psychiatry fellowship program directors in the United States to assess current palliative care training practices. Methods Web-based anonymous survey of geriatric psychiatry fellowship training directors Results Forty-six percent (28/61) of program directors responded. Seventy one percent (20/28) of programs provide didactics on palliative care. Seventy-seven percent (20/26) of programs provide clinical experiences in palliative care. Sixty-three percent (15/24) have formalized interactions between geriatric psychiatry and palliative care fellows. Conclusions Palliative care training for geriatric psychiatry fellows is robust but unstandardized. Operationalizing palliative care training for geriatric psychiatrists may improve mental health integration into serious illness care.
Tenascin-C expression in the lymph node pre-metastatic niche in muscle-invasive bladder cancer.

Background Markers of stromal activation at future metastatic sites may have prognostic value and may allow clinicians to identify and abolish the pre-metastatic niche to prevent metastasis. In this study, we evaluate tenascin-C as a marker of pre-metastatic niche formation in bladder cancer patient lymph nodes. Methods Tenascin-C expression in benign lymph nodes was compared between metastatic (n = 20) and non-metastatic (n = 27) patients with muscle-invasive bladder cancer. Urinary extracellular vesicle (EV) cytokine levels were measured with an antibody array to examine potential correlation with lymph node inflammation. The ability of bladder cancer EVs to activate primary bladder fibroblasts was assessed in vitro. Results Lymph node tenascin-C expression was elevated in metastatic patients vs. non-metastatic patients, and high expression was associated with worse survival. Urinary EVs contained four cytokines that were positively correlated with lymph node tenascin-C expression. Bladder cancer EVs induced tenascin-C expression in fibroblasts in an NF-κB-dependent manner. Conclusions Tenascin-C expression in regional lymph nodes may be a good predictor of bladder cancer metastasis and an appropriate imaging target. It may be possible to interrupt pre-metastatic niche formation by targeting EV-borne tumour cytokines or by targeting tenascin-C directly.
The effects of conventional and unconventional monetary policy on exchange rate volatility

This paper examines the impacts of U.S. conventional and unconventional monetary policy announcements on the volatility of six exchange rates, namely Australian dollar, British pound, Canadian doll...
“Interaction” in a System of Concepts

Something that hangs by itself may be said to “dangle”. A concept that hangs by itself I call a dangling concept. Just as proper grammar has no place for dangling participles, advanced science has no place for dangling concepts. A more complete description of such concepts, as well as an examination of the degree to which this idea applies to “interaction”, are the subjects of this chapter. In particular I examine some scientific concepts that are candidates to combine with “interaction” to form concept systems. But my first task is to elucidate the idea of a dangling concept.
Contribution of sympathetic activation to coronary vasodilatation during the cold pressor test in healthy men: effect of ageing

The sympathetic nervous system is an important regulator of coronary blood flow. The cold pressor test (CPT) is a powerful sympathoexcitatory stressor. We tested the hypotheses that: (1) CPT-induced sympathetic activation elicits coronary vasodilatation in young adults that is impaired with advancing age and (2) combined α- and β-adrenergic blockade diminishes/abolishes these age-related differences. Vascular responses of the left anterior descending artery to the CPT were determined by transthoracic Doppler echocardiography before (pre-blockade) and during (post-blockade) systemic co-administration of α- and β-adrenergic antagonists in young (n = 9; 26 ± 1 years old, mean ± SEM) and older healthy men (n = 9; 66 ± 2 years old). Coronary vascular resistance (CVR; mean arterial pressure/coronary blood velocity) was used as an index of vascular tone. CPT decreased CVR (i.e. coronary vasodilatation occurred) in young ( -33 ± 6%), but not older men ( -3 ± 4%; P 0.05 compared to young pre-blockade). Impaired CPT-induced coronary vasodilatation could not be explained by a reduced stimulus for vasodilatation as group and condition effects persisted when CVR responses were expressed relative to myocardial oxygen demand (rate-pressure product). These data indicate that the normal coronary vascular response to sympathetic activation in young men is pronounced vasodilatation and this effect is lost with age as the result of an adrenergic mechanism. These findings may help explain how acute sympathoexcitation may precipitate angina and coronary ischaemic events, particularly in older adults.
ESCHERICHIA COLI ENTEROHEMORRAGICA Y SINDROME UREMICO HEMOLITICO EN ARGENTINA

.es un desorden multisistemico caracterizado por presentar insuficiencia renal aguda, anemia hemolitica microangiopatica y trombocitopenia. Constituye la principal causa de insuficiencia renal aguda y la segunda causa de insuficiencia renal cronica y de transplante renal en ninos en la Argentina. Actualmente, nuestro pais presenta el registro mas alto de SUH en todo el mundo, con aproximadamente 420 casos nuevos declarados anualmente y una incidencia de 12.2/100 000 ninos menores de 5 anos de edad. Se reconocen multiples agentes etiologicos, aunque se considera a la infeccion por Escherichia coli enterohemorragica (EHEC) como la principal etiologia de SUH. La gran mayoria de brotes epidemicos y casos esporadicos en humanos se han asociado con el serotipo O157:H7, aunque otros serotipos han sido tambien aislados, y estos son un subgrupo de E. coli verocitotoxigenico (VTEC)..El bovino es considerado el principal reservorio de VTEC. El contagio al hombre frecuentemente se debe al consumo de alimentos carneos y lacteos contaminados, deficientemente cocidos o sin pasteurizar, o al contacto directo con los animales o con sus heces, consumo de agua, frutas o verduras contaminadas. Tambien puede producirse contagio mediante el contacto interhumano. Palabras clave: sindrome uremico hemolitico, Escherichia coli enterohemorragica (EHEC), bovinos, Argentina
Steric inhibition of π-electron delocalization in 1, 3-dienes

Abstract The conjugated diene, “methylisopulegene” (1, 1-isopropenyl-2,4-dimethyl-1-cyclohexene), exhibits a CD Cotton effect (CE) with Δe217= + 1.77 but no UV maximum down to 200nm; whereas, the structurally related conjugated diene, 3,-8-p-menthadiene (2, 1-isopropenyl-4-methyl-1-cyclohexene), exhibits a more normal UV maximum at 232 nm (e = 17,300) and a CE with Δe240 = +2.56.
On Marginal Effects in Semiparametric Censored Regression Models

This note illustrates that the typical parameter, beta, in a censored regression model can be used to calculate an interesting marginal effect even when the errors in the model and the explanatory variables are not independent. The result is relevant for cross sectional models such at the ones considered in Powell (1984), Powell (1986) and Chen and Khan (2000), as well as for panel data models such as the ones in Honore (1992) and Alan and Leth-Petersen (2006), and it applies with fixed as well as with random censoring.
OSTEOARTHRITIS : A CONTINUING CHALLENGE

Osteoarthritis is a disorder of cartilage that affects almost 85% of the population by age 75. A lack of rigorous clinical and radiographic criteria for defining the disorder makes precise determination of its prevalence impossible. The process of wear and tear explains many manifestations of osteoarthritis, but it does not account for some of the clinical findings or the biochemical changes in osteoarthritic cartilage. Thus, other factors such as heredity, hormones, and diet may play a role. Treatment consists of teaching patients about their disease, alleviating pain, and preserving joint function. Nonsteroidal anti-inflammatory drugs may be no more effective than simple analgesics in relieving the pain of this disorder. Moreover, some nonsteroidal anti-inflammatory drugs can adversely affect cartilage metabolism, and most are possibly dangerous in elderly patients. Drugs that inhibit the production or activity of chondrolytic enzymes can slow the degeneration of cartilage in some animals, but their effects on humans with osteoarthritis are unproved. The surgical repair of severely damaged joints can have gratifying results.
The Development of Political Imagination in Public Housing

Although welfare recipients undergo political learning from welfare bureaucracies, I disagree that this is where political development begins and ends. In this paper I argue that Chicago public housing policy has created a public sphere where low-income people develop political imagination through public-spirited conversation. Drawing from six months of ethnographic fieldwork and in-depth interviews, I find that, despite at times being denied access to the larger public sphere, public housing residents have found ways to effect change within their own smaller public spheres. While public housing resident political advocacy often goes on under the radar of the larger public eye, it is still very much happening in ways that are effective and significant. My argument takes Joe Soss’ work, as well as the work of others within the policy feedback literature, as a point of departure, and interrogates the way in which low-income people act politically in creative and poignant ways.
Contrasts between platinum group element contents and biotite compositions of Duluth Complex troctolitic and anorthositic series rocks

This paper presents new data on sulfide assemblages, platinum group elements (PGE's) and halogen contents of biotites in anorthositic series rocks from the Duluth Complex. The data are contrasted with similar data from troctolitic series rocks. Sulfides occur in only trace amounts in anorthositic series rocks as interstitial grains, inclusions in plagioclase, and veinlets cutting olivine. These textures and the sulfide assemblage (pyrrhotite, pentlandite and chalcopyrite) are similar to the sulfide mineralization in troctolitic series rocks. However, the sulfide assemblage is dominated by chalcopyrite in anorthositic rocks. The highest concentration of PGE's in anorthositic series rocks found to date is 163 ppb Pt, with the bulk of the data at limits of detection. PGE contents of troctolitic series rocks range from 100=200 ppb Pt + Pd to an anomalously high 14 ppm Pt + Pd over a one meter interval. The variation of F/Cl ratios with Fe-Mg compositions of Duluth Complex magmatic biotites may be interpreted to imply equilibration with a fluid phase of constant composition. We have no definitive interpretation of the significance of the distinctly different biotite compositions reported from the Stillwater and Bushveld Complexes.
Subcritical Noise Measurements with a Nickel-Reflected Plutonium Sphere

Subcritical measurements were conducted with an α-phase plutonium sphere reflected by nickel hemishells using the 252Cf source-driven noise analysis method to provide criticality safety benchmark d...
Multidisciplinary teamwork in primary care: The role of the counsellor

Since other professionals have joined doctor and nurse to form multidisciplinary working groups, primary health care teams have made efforts, more or less successfully, to work together. This paper views the primary health care team as a medium-sized, multidisciplinary, family-like organization with very specific characteristics. Full of promise as a synergistic body, nevertheless the team frequently struggles with difficult and even self-destructive dynamics. The structures, problems and values of teamworking in this specialized context are examined, with particular attention given to ways in which the practice counsellor can support and encourage team working. Suggestions are offered regarding how primary health care teams might move towards a more team-oriented approach.
The Efficiency Instability Problem of Coaxial Germanium Detectors

The generally accepted belief in constant fullenergy peak efficiency for coaxial germanium gamma ray detectors maintained at liquid nitrogen temperature has been found to be invalid in many cases. A majority of the available raw germanium ingots possess a shortcoming which causes detectors to decline in efficiency with time, if the standard techniques described in the literature have been employed for their production. A strong correlation of efficiency instability with ingot has been established. The time rate of change varies markedly from ingot to ingot. Over 60% of the ingots studied resulted in detectors whose efficiencies declined at rates greater than 8% per year. A substantial fraction of the cases studied displayed relative decreases of 10-20% in a period of six months. Declines of as much as 10-25% in several weeks were also observed.
Issues and strategies for integrating HCI in masters level MIS and e-commerce programs

Human-computer interaction (HCI) is an important knowledge component for graduate management information systems (MIS) and E-commerce (EC) programs. HCI topics, such as user-centered design and usability testing, have begun to receive increasing attention in MIS/ EC curricula because of their importance in the development of Web-based solutions. This paper discusses issues and approaches for integrating HCI topics into masters level MIS/EC programs. Research on HCI topics related to MIS provides a theoretical foundation for student learning. By bridging research with these curricula, researchers are challenged to examine how HCI approaches can improve user acceptance of new systems. A case study illustrates how HCI topics can be taught as a stand-alone course or incorporated in existing MIS/EC courses. Drawing from the case study, the paper also addresses pedagogical challenges regarding student skill sets, learning outcomes, innovative pedagogies, tools and technology, and HCI issues for advanced IS/EC topics.
The μ-opioid activity of κ-opioid receptor agonist compounds in the guinea pig ileum

Abstract On the basis of their in vivo activity and binding affinity, nalorphine and (−)SKF 10,047 were classified as mixed agonist/antagonist compounds. However, in isolated tissue preparations without a selective antagonist to block their agonist effect, the characterization of these compounds and the determination of their antagonist activity were very difficult. Nor-binaltorphimine, a selective κ-opioid receptor antagonist, was used in the longitudinal muscle preparations of the guinea pig ileum to block the κ-agonist activity of nalorphine and (−)SKF 10,047. In the absence of their κ-agonist activity, we were able to determine the μ-antagonist activity using the μ-selective agonist DAMGO ([D-Ala 2 ,N-Me-Phe 4 ,Gly-ol 5 ]enkephalin). The pA 2 values for nalorphine and (−)SKF 10,047 were 7.50 and 7.69, respectively.
A look at 1983 CO2 emissions from fossil fuels (with preliminary data for 1984)

During 1983, global emissions of CO2 from fossil fuels continued to decline slightly, to a value of 4932 millions tons carbon compared to 4957 million tons carbon in 1982. This marked the 4th consecutive year that CO2 emissions from fuel use has declined. Even though cement production has continued to increase very slowly, the annual CO2 emissions from the combination of fuels and cement showed the relative decline that occurred in emissions from fuels alone. Although preliminary, data for 1984 strongly suggest that the decline is over; CO2 emissions in 1984 were greater than any previous year other than 1979. Examination of each fuel type reveals that the decline in the total emissions between 1979 and 1983 was a result of reduced use of liquid fuels. Both gas and solid fuels continue to grow, albeit at a very slow pace. Growth in fossil fuel use and resulting CO2 emissions has continued in the developing world in contrast to the decline observed in developed countries of the western world in recent years. This could have important implications for growth in global emissions in future years.
A longitudinal view of the liberal arts curriculum a decade after merger : a multiple case study of community colleges in Connecticut, Kentucky, and Louisiana.

This study is an examination of the state of the liberal arts curriculum in community colleges in three geographic regions of the United States. From a constructivist paradigm and using globalization theory as a theoretical framework, this multiple case study examined faculty work life and administrative processes related to curriculum change in merged community and technical colleges. Through an examination of research on globalization, mergers, and trends in the general education and liberal arts curriculum, a gap in the literature emerged in the studies of community college curriculums after merger. This study considers whether the focus on workforce development and decrease in the transfer mission has diminished the liberal arts courses in the college curriculum. Research on liberal arts courses identified them as courses that emphasize higher order thinking and the development of intellectual skills needed to engage in a democratic society. If students are not exposed to these skills, it may have a d...