cssi/SciSciGPT-SciSciNet huggingface dataset:
Treatment of salivary gland neoplasms with fast neutron radiotherapy.

Objective To evaluate the efficacy of fast neutron radiotherapy for the treatment of salivary gland neoplasms. Design Retrospective analysis. Setting University of Washington Cancer Center, Neutron Facility, Seattle. Patients The medical records of 279 patients treated with curative intent using fast neutron radiotherapy at the University of Washington Cancer Center were reviewed. Of the 279 patients, 263 had evidence of gross residual disease at the time of treatment (16 had no evidence of gross residual disease), 141 had tumors of a major salivary gland, and 138 had tumors of minor salivary glands. The median follow-up period was 36 months (range, 1-142 months). Main Outcome Measures Local-regional control, cause-specific survival, and freedom from metastasis. Results The 6-year actuarial cause-specific survival rate was 67%. Multivariate analysis revealed that low group stage (I-II) disease, minor salivary sites, lack of skull base invasion, and primary disease were associated with a statistically significant improvement in cause-specific survival. The 6-year actuarial local-regional control rate was 59%. Multivariate analysis revealed size 4 cm or smaller, lack of base of skull invasion, prior surgical resection, and no previous radiotherapy to have a statistically significant improved local-regional control. Sixteen patients without evidence of gross residual disease had a 100% 6-year actuarial local-regional control. The 6-year actuarial freedom from metastasis rate was 64%. Factors associated with decreased development of systemic metastases included negative lymph nodes at the time of treatment and lack of base of skull involvement. The 6-year actuarial rate of development of grade 3 or 4 long-term toxicity (using the Radiation Therapy Oncology Group and European Organization for Research on the Treatment of Cancer criteria) was 10%. No patient experienced grade 5 toxic effects. Conclusions Neuron radiotherapy is an effective treatment for patients with salivary gland neoplasms who have gross residual disease and achieves excellent local-regional control in patients without evidence of gross disease.
Ice-Nucleation-Active Bacteria on Citrus in Florida

A survey for ice-nucleation-active (INA) bacteria on citrus leaves was made in two locations in the north of the citrus zone in Florida. The first sample of leaves was collected in April, 1984 and additional samples were collected monthly until January, 1985. In one location leaves were taken from a single tree and in the other leaves were taken from 25 trees in a block. The mean number of total bacteria per leaf isolated varied from log10 3.3 to log10 6.2, and the mean number of INA bacteria per leaf did not exceed log10 3.8. Ice-nucleation-active bacteria were isolated from 3 of 10 monthly collections from one location and 7 of 9 monthly collections from the other location. The percentage of leaves with INA bacteria varied from 0 to 33 and 0 to 50, respectively. Four different species of INA bacteria were isolated from 19 collections; Pseudomonas viridiflava from 6, P. syringae from 1, Erwinia herbicola from 5, and Xanthomonas campestris from 1.
Up Close and Personal: Ethics-Guided Practice

This article focuses upon the practical utilization of the APA Ethical Principles of Psychologists and Code of Conduct (APA 2010a), henceforth termed the Ethics Code, in the course of everyday clinical practice. The article is divided into the following sections: (1) introduction outlining the contextual approach to ethics-guided practice, (2) description of the varied elements of the Ethical Principles in the current Code and presentation of a rationale emphasizing application of those principles in clinical practice, (3) ethical decision-making and demonstration of a truncated version of a field-tested decisional model, and (4) practical applications of the five ethical principles in situations involving several diagnostic populations with neurological impairment, focusing upon vulnerabilities inherent in those diagnostic categories and emphasizing ethical considerations for the practitioner.
Generalizations of Horner's rule for polynomial evaluation

Polynomials are generally evaluated by use of Horner's rule, sometimes referred to as the nesting rule. This rule is sequential and affords no opportunity for parallecl omputation, i.e., completion of several of the arithmetic operations simultaneously. Two generalizations of Horner's rule which allow for parallel computation are presented here. Schedules and, in some cases, machine codes for evaluating a polynomial on a computer with several parallel arithmetic units are developed. Some advantages of the generalized rules in sequential computations on a computer with a single arithmetic unit are presented.
International Economics: Global Markets and Competition (3rd Edition)

This book integrates the microeconomics of trade with international finance and open economy macroeconomics. The emphasis throughout is on international competition and the limits of trade policy.Economics began with a debate over tariffs. Domestic industries lobby for protection against foreign competitors or export subsidies. Government policy makers dole favors in return for cash and votes. Governments negotiate free trade agreements but disregard them when possible with tariffs, export subsidies, and other policies to influence foreign trade and investment. The forces of international competition, however, eventually overwhelm government policy.This text presents the critical issues of international trade and finance. Trade theory includes partial equilibrium market analysis, neoclassical trade models, constant cost production, factor proportions production, and models of industrial organization. The text integrates concepts from international finance and the basic models of open economy macroeconomics.The presentation uses graphs with numerical examples making the theory easier for students, especially when combined with more general classroom presentation. The text does not assume previous courses in intermediate economics or calculus but develops the theory with simple tools. Numerous questions give students confidence to use the theoretical models and concepts.Over 250 boxed examples illustrate the theory, many with visually descriptive charts and plots. The text is concise in its presentation style. Students enjoy its clear straightforward style and instructors notice the difference on exams. Contents: Trade and Protectionism: Markets and Trade; Gains from Trade; Protectionism; Terms of Trade; Production and Trade: Trade with Constant Cost Production; Factors of Production of Trade; Industrial Organization and Trade; International Integration: International Migration and Captial; International Economic Integration; International Macroeconomics: Balance of Payments; Foreign Exchange Rates; Money and International Financial Markets; Open Economy Macroeconomics.
Thermodynamic Contributions to the Stability of the Insulin Hexamer

The insulin hexamer is resistant to degradation and fibrillation, which makes it an important quaternary structure for its in vivo storage in Zn2+- and Ca2+-rich vesicles in the pancreas and for pharmaceutical formulations. In addition to the two Zn2+ ions that are required for its formation, three other species, Zn-coordinating anions (e.g., Cl–), Ca2+, and phenols (e.g., resorcinol), bind to the hexamer and affect the subunit conformation and stability. The contributions of these four species to the thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer. Both Zn2+ and resorcinol make a significant enthalpic contribution, while Ca2+ primarily affects the protein heat capacity (solvation) by its interactions in the central cation-binding cavity, which is modulated by the surrounding subunit conformations. Coordinating anions have a negligible effect on ...
Current status of nosocomial infection management in children rehabilitation department and monitoring measures

OBJECTIVE To understand the current status of nosocomial infection management in rehabilitation department of grassroots children hospital and to explore corresponding monitoring measures.METHODS The current status of nosocomial infection management in rehabilitation department was investigates and analyzed,the countermeasures for prevention and control of hospital infection were formulated.RESULTS There were shortcomings in nosocomial infection management in rehabilitation department of our hospital in the management system,protection awareness,hand washing compliance,distribution of training room,and hygiene of the training appliance,and so on.CONCLUSION The problems in the nosocomial infection management in rehabilitation department of grassroots children′s hospital are highlighted.It is necessary to take comprehensive management measures to effectively prevent and control nosocomial infections.
Myosin light chain efflux after heart transplantation in infants and children and its correlation with ischemic preservation time.

Serum levels of cardiac myosin light chain 1 after heart transplantation were studied in 24 infants and children who underwent heart transplantation between June 1990 and April 1991. The ages of the patients ranged from 4 days to 6 years 7 months (mean, 9.9 months), and their body weights ranged from 2.2 to 20 kg (mean, 5.6 kg). The ages of the donors ranged from 2 days to 8 years, 7 months (mean, 26.6 months), and their body weights ranged from 2.5 to 26 kg (mean, 11.4 kg). The donor heart ischemic time ranged from 90 minutes to 482 minutes (mean, 279 minutes). Peak myosin levels after heart transplantation showed significant correlation with the duration of graft ischemia (p
Performance of a composite bioactive membrane for H2 production and capture from high strength wastewater

In this study, a composite bioactive membrane was developed and tested to generate and capture hydrogen (H2) during the process of wastewater treatment. Hollow fiber membranes were coated with encapsulated acetogenic bacteria to simultaneously produce and capture H2 from waste feedstocks. Acetogens were encapsulated with cast poly(vinylalcohol) or electrospun microfibers. Under anaerobic conditions the poly(vinylalcohol) and electrospun composite membranes produced an average of 44.6 ± 11.3 mL H2 g−1 hexose (0.33 ± 0.08 mol H2 mol−1 hexose) and 21.2 ± 4.8 mL H2 g−1 hexose (0.16 ± 0.04 mol H2 mol−1 hexose), respectively, and captured 73 ± 12% and 57 ± 11%, respectively, of the total H2 produced in bioreactors fed synthetic high strength wastewater. The H2 capture efficiency of the electrospun composite membrane was improved by coating the modules with a thin film of polymeric silica gel, improving the H2 production to 28.3 ± 2.3 mL H2 per hexose (0.21 ± 0.02 mol H2 mol−1 hexose) and the H2 capture efficiency to 73 ± 15%. Final composite membranes were built by immobilizing bacteria directly onto the membrane surface, again improving H2 yields from high strength synthetic wastewater to a maximum of 48.4 ± 9.4 mL H2 g−1 hexose (0.36 ± 0.07 mol H2 mol−1 hexose) with a maximum H2 capture efficiency of 86 ± 9%. The optimized composite membranes were also capable of generating and capturing H2 from real wastewaters, with yields and capture efficiencies of 19.2 ± 3.0 mL H2 g−1 hexose (0.14 ± 0.02 mol H2 mol−1 hexose) and 99.1 ± 0.2%, and 46.0 ± 15.5 mL H2 g−1 hexose (0.34 ± 0.12 mol H2 mol−1 hexose) and 79 ± 19% when tested with a feed of sugar beet wastewater and dairy production wastewater, respectively. After further optimization, the composite membrane system could allow the extraction of high-quality energy from wastewater.
Voting Deliberatively: FDR and the 1936 Presidential Election Campaign. By Mary E.Stuckey. University Park, PA: The Pennsylvania State University Press, 2015. 154 pp.: Book Review

Voting Deliberatively: FDR and the 1936 Presidential Election Campaign. By Mary E. Stuckey. University Park, PA: The Pennsylvania State University Press, 2015. 154 pp. When considering Franklin Delano Roosevelt's presidential campaigns, the first one likely to come to mind is his trouncing of Herbert Hoover in 1932, an election that took place in the midst of the Great Depression and one in which Roosevelt defeated a highly unpopular Hoover by more than 17 percentage points in the popular vote and won the Electoral College by a margin of 413 votes. Roosevelt's famed First Hundred Days and myriad legislative accomplishments in his first term set up his even more lopsided defeat of Kansas governor Alf Landon in the election of 1936. This time, Roosevelt received over 60 percent of the popular vote while winning all but two states. FDR's triumph in 1936 is often seen as simply the second of four decisive campaigns, as well as an affirmation that he was one of the most popular presidents of the modern era. But Mary E. Stuckey's Voting Deliberatively suggests that the 1936 election was more than a mere stepping stone in Roosevelt's storied political career. Stuckey argues that the election of 1936 was, in fact, fraught with uncertainty, as criticism of Roosevelt from both the Left and the Right was unceasing, and continued economic uncertainty, high unemployment, and political upheaval left the election as anything but a foregone conclusion. More importantly, though, Stuckey argues that it was also a watershed moment in American politics, one that ushered in several new elements of political campaigning that are still with us today. To Stuckey, the election of 1936 is an under-examined, yet important moment in American history. Dissecting Roosevelt's campaign into its various features, Voting Deliberatively identifies four pioneering and intentional strategies that Roosevelt and his aides employed: new ways of assessing public opinion; the mobilization of voters through what we now refer to as a "ground game"; identifying and segmenting blocks of voters by group affiliation (women, blue collar, Protestant, etc.); and employing persuasive appeals that signaled a new kind of presidential rhetoric, one that was both authoritative and deeply personal. According to Stuckey, Roosevelt's 1936 campaign was the first to use both anecdotal and nominally scientific means of understanding the concerns and attitudes of the American public. Stuckey describes the various ways in which Roosevelt's team members embarked on an unprecedented data collection program that allowed them to quantitatively assess both the electorate as a whole and individual demographic slices of the American populace--advances that Stuckey argues had both positive and negative ramifications for American democracy. …
Evaluation of new farming technologies in Ethiopia using the Integrated Decision Support System (IDSS)

This study investigates multi-dimensional impacts of adopting new technology in agriculture at the farm/village and watershed scale in sub-Saharan Africa using the Integrated Decision Support System (IDSS). Application of IDSS as an integrated modeling tool helps solve complex issues in agricultural systems by simultaneously assessing production, environmental, economic, and nutritional consequences of adopting agricultural technologies for sustainable increases in food production and use of scarce natural resources. The IDSS approach was applied to the Amhara region of Ethiopia, where the scarcity of resources and agro-environmental consequences are critical to agricultural productivity of small farm, to analyze the impacts of alternative agricultural technology interventions. Results show significant improvements in family income and nutrition, achieved through the adoption of irrigation technologies, proper use of fertilizer, and improved seed varieties while preserving environmental indicators in terms of soil erosion and sediment loadings. These pilot studies demonstrate the usefulness of the IDSS approach as a tool that can be used to predict and evaluate the economic and environmental consequences of adopting new agricultural technologies that aim to improve the livelihoods of subsistence farmers.
"La nuit de la langue perdue": Défaite et legs de la mère dans "Vaste est la prison" d'Assia Djebar

"Pendant architectonique et epistemologique du roman du legs des peres qu’est L’amour, la fantasia (1985), le premier volume du projet de “quartet algerien” d’Assia Djebar, Vaste est la prison (1995) privilegie le legs des femmes mais, comme une photographie que l’on developpe, cette primaute ne se revele que lentement par couches successives d’accents, d’echos et de sillages entrecroises des recits. D’une structure en apparence eparse et dodecaphonique, le roman joue sur le rythme narratif et sur les points d’intersection de quatre chronotopes (chronotopes de la vie intime de la narratrice dans la “Premiere Partie”, de l’heritage linguistique antique de l’Algerie dans la seconde, de la genealogie familiale de la narratrice dans la troisieme et enfin de sa relation a la guerre civile des annees 1990) pour inviter et dejouer les tentatives de lecture suivie de la transmission du savoir des femmes."
Volcanic lake systematics II. Chemical constraints

Abstract A database of 373 lake water analyses from the published literature was compiled and used to explore the geochemical systematics of volcanic lakes. Binary correlations and principal component analysis indicate strong internal coherence among most chemical parameters. Compositional variations are influenced by the flux of magmatic volatiles and/or deep hydrothermal fluids. The chemistry of the fluid entering a lake may be dominated by a high-temperature volcanic gas component or by a lower-temperature fluid that has interacted extensively with volcanic rocks. Precipitation of minerals like gypsum and silica can strongly affect the concentrations of Ca and Si in some lakes. A much less concentrated geothermal input fluid provides the mineralized components of some more dilute lakes. Temporal variations in dilution and evaporation rates ultimately control absolute concentrations of dissolved constituents, but not conservative element ratios. Most volcanic lake waters, and presumably their deep hydrothermal fluid inputs, classify as immature acid fluids that have not equilibrated with common secondary silicates such as clays or zeolites. Many such fluids may have equilibrated with secondary minerals earlier in their history but were re-acidified by mixing with fresh volcanic fluids. We use the concept of ‘degree of neutralization’ as a new parameter to characterize these acid fluids. This leads to a classification of gas-dominated versus rock-dominated lake waters. A further classification is based on a cluster analysis and a hydrothermal speedometer concept which uses the degree of silica equilibration of a fluid during cooling and dilution to evaluate the rate of fluid equilibration in volcano-hydrothermal systems.
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and metabolism in response to nutrients, energy levels, and growth factors. It contains the atypical kinase mTOR and the RAPTOR subunit that binds to the Tor signalling sequence (TOS) motif of substrates and regulators. mTORC1 is activated by the small GTPase RHEB (Ras homologue enriched in brain) and inhibited by PRAS40. Here we present the 3.0 angstrom cryo-electron microscopy structure of mTORC1 and the 3.4 angstrom structure of activated RHEB-mTORC1. RHEB binds to mTOR distally from the kinase active site, yet causes a global conformational change that allosterically realigns active-site residues, accelerating catalysis. Cancer-associated hyperactivating mutations map to structural elements that maintain the inactive state, and we provide biochemical evidence that they mimic RHEB relieving auto-inhibition. We also present crystal structures of RAPTOR-TOS motif complexes that define the determinants of TOS recognition, of an mTOR FKBP12-rapamycin-binding (FRB) domain-substrate complex that establishes a second substrate-recruitment mechanism, and of a truncated mTOR-PRAS40 complex that reveals PRAS40 inhibits both substrate-recruitment sites. These findings help explain how mTORC1 selects its substrates, how its kinase activity is controlled, and how it is activated by cancer-associated mutations.
In Briddes Wise: Chaucer’s Avian Poetics

Chaucer’s poetry is filled with beasts and birds that narrate stories and sing tales. Birds, in particular, do not just “maken melodye” or serve as the main actors in a story. Many of Chaucer’s birds engage in active discourse, speaking to humans or to each other in “briddes wise,” a highly articulate and expressive speech. This speech is more than representational; it stands alongside human speech as a fully articulate language, albeit a language that humans can only experience through translation. Chaucer endows the avian world with a series of communicative strategies as diverse as—and profoundly linked to—his own poetic strategies; however, its meaning can only be derived through anthrosemiotic representation. Challenging notions of the animal/human boundary, Chaucer offers the potential for a deeply communicative, poetic exchange.
Clinical Context and Detection of the Murmur of Advanced Aortic Stenosis.

OBJECTIVES Auscultation is an important clue to the presence of aortic stenosis (AS). We sought to assess the effect of symptom status, prior knowledge of diagnosis, and other patient factors on murmur detection. METHODS Patients with moderate-to-severe AS by echocardiography at a single center between June 2015 and June 2016 were included. Five consecutive patient encounters (inpatient and outpatient) within 12 months before the echocardiogram were analyzed. RESULTS Ninety-five patients (418 different clinician encounters) were studied. The murmur of AS was identified by only 39% of clinicians. In multivariate analysis, significant determinants of murmur detection were examination in outpatient setting (odds ratio [OR] 3.40, 95% confidence interval [CI] 1.75-6.61), known history of AS (OR 2.77, 95% CI 1.53-5.01), female sex (OR 1.97, 95% CI 1.07-3.60), and presence of symptoms (OR 1.91 95% CI 1.12-3.26). Compared with the murmur detection findings by clinicians in medicine, the findings of surgical specialty clinicians were significantly lower (OR 0.12, 95% CI 0.06-0.26, P < 0.001). CONCLUSIONS In this real-world assessment, clinical context played an important role in the auscultation of AS murmur. The findings have important implications for the clinical diagnosis of asymptomatic advanced AS.
The impact of placement in introductory computer science courses on student persistence in a computing major

Multiple studies have shown that when novice and experienced programmers are enrolled in the same introductory programming course, the novice programmers are negatively impacted. We have two entry points into our course sequence for majors. One course is intended for students with little or no programming experience, while the alternate course is intended for students who have had previous programming experience. In 2015 we discovered that many students with programming experience were enrolling in the course for novice programmers. A change in our placement strategy in 2016 resulted in a greater portion of the students with programming experience actually enrolled in the course intended for students with programming experience. Last year we reported on the impact this change had on the courses and the students enrolled in these introductory courses. Although student performance improved only slightly, many fewer students with little or no previous programming experience reported that their first programming course was unreasonably difficult in 2016. In this paper we examine how this change in placement strategy and resulting changes in the courses is impacting student persistence in the major. Initial indications are that a greater percentage of students with little or no previous programming experience are persisting in their computing major when these students begin in an introductory course that does not also include students who have substantial programming experience.
From Coin Flipping to Motion of Molecules

Down among the atoms and molecules randomness rules. Gas molecules rush around in all directions with different speeds, their tracks jagged, zigzag, full of turns and reverses. Disordered. Random. Unpredictable.
Molybdenum-Nitrogenase: Structure and Function

Molybdenum (Mo) was believed, as early as 1930, to be absolutely essential for nitrogen fixation, even though vanadium (V) was found to be almost as stimulatory to bacterial growth on N2 (1). Recently, however, it has been shown that biological nitrogen fixation can occur without Mo. Nitrogenase is now known to exist in three genetically distinct forms; the conventional Mo-based system (Mo-nitrogenase) and the two alternative systems, V-nitrogenase and nitrogenase-3 (2–4). In general, the enzymes from all N2-fixing bacteria are very similar, comprising two component proteins. For Mo-nitrogenase, these are the MoFe protein and the Fe protein (5), neither of which has activity alone. The deduced amino-acid sequences of the subunits of the MoFe, VFe and FeFe proteins show significant identity with one another and the conservation of both the domain structures around the eight strictly conserved Cys residues and the spacing between them indicates that all three protein types will have the same general structural features. All N2-fixing species examined so far have Mo-nitrogenase. In some species, it occurs alone, while in others it is found in all permutations with the V-based and third systems. It is not at all clear why each species has its own combination of these nitrogenases (6). This paper reviews only studies of the Mo-based nitrogenase system.
Comparative study of macroporous silicon-based photovoltaic characteristics using indium tin oxide-silicon and pn-silicon junction based devices.

Abstract We report highly ordered macroporous silicon (Si)-based photovoltaic characteristics using indium tin oxide (ITO)/n-Si and pn-Si junction-based devices. The detailed fabrication processes including new controlled ITO etching are presented. Theoretical device simulations are performed to understand the presented device structures and propose an optimum device design based on processing limitations. The performance of ITO/n-Si junction devices directly depends on the conformal ITO coating along the pore surface. While pn-Si junction device requires additional doping step, the device can overcome the limitation of ITO conformal coating, especially for a device with high-aspect-ratio macropore structures. Experimental results also support the simulation analysis. The three-dimensional structural properties of well-defined macroporous Si coupled with the formation of photovoltaic devices are attractive for multi-functional applications.
Older HIV+ and HIV- Adults Provide Similar Definitions of Successful Aging: A Mixed-Methods Examination.

Author(s): Fazeli, Pariya L; Montoya, Jessica L; McDavid, Chastity N; Moore, David J | Abstract: Background and objectiveAs HIV-infected (HIV+) individuals age, there is a need to understand successful aging (SA) from the patient perspective. This study compared SA definitions between HIV+ and HIV-uninfected (HIV-) older adults and then examined correlates of SA categories.Research design and methodsNinety-three HIV+ and 46 HIV- older (aged 50+) adults provided brief definitions of SA, which was examined using content analysis. We then compared the frequency of SA categories by serostatus and examined the correlates of SA categories within both groups.ResultsSeven SA categories emerged: General Health, Cognitive Health a Ability, Physical/Biological Health a Ability, Social Relationships, Attitudes, Psychological, a Emotional Well-Being, Proactive a Engaged Lifestyle, and Independence. While no significant differences emerged, HIV- older adults were more likely to report General Health and the subcategory of Longevity/Survival, while HIV+ older adults were more likely to report subcategories of Enjoying Life a Fulfillment and Maintaining Balance. Few demographic correlates of SA categories emerged. Mood and HIV characteristics were not associated with SA categories. In both groups, those without neurocognitive impairment were significantly more likely to endorse General Health than those with neurocognitive impairment.Discussion and implicationsHIV+ and HIV- older individuals may generally perceive SA similarly, and their definitions parallel with existing models of SA. Yet, living with a chronic illness may cause HIV+ older adults to place greater value on quality of life and life satisfaction than physical health and chronological age. Observational and intervention studies may use similar approaches in evaluating and maximizing SA.
Clopidogrel-Associated Migratory Inflammatory Polyarthritis

BACKGROUND Clopidogrel is an antiplatelet medication that plays an important role in primary management and secondary prevention of thrombotic vascular events in patients with acute coronary syndrome. It is generally well tolerated by most patients, but rare adverse effects such as inflammatory arthritis has been noted. A very few cases of migratory polyarthritis secondary to clopidogrel have been reported in the literature. CASE REPORT We describe 2 cases of acute migratory polyarthritis associated with clopidogrel that resolved with discontinuation of clopidogrel and did not recur after prasugrel initiation. In the first case, the patient presented with migratory polyarthritis approximately 2-3 days after initiating clopidogrel, and the symptoms lasted in each joint for 1-2 days. In the second case, the migratory polyarthritis started 1 week after initiating clopidogrel, and the symptoms lasted in each joint for approximately 2-3 days. The symptoms completely resolved after discontinuing clopidogrel in both the cases, which is typical of an immune-mediated drug reaction. A diagnosis of acute migratory inflammatory polyarthritis related to clopidogrel was determined in both cases by excluding other conditions causing inflammatory arthritis. In both cases, the eosinophil count was within normal limits, thereby differentiating the disease process from an acute allergic reaction. CONCLUSIONS Identifying the etiology of inflammatory arthritis in a patient on clopidogrel needs extensive evaluation. The diagnosis of clopidogrel-related inflammatory arthritis is often missed due to lack of awareness. Early diagnosis and timely intervention are essential, as the symptoms completely resolve after discontinuing clopidogrel.
Survey of Heteronormative Attitudes and Tolerance Toward Gender Non-conformity in Mountain West Undergraduate Students

Introduction: Heteronormative attitudes are prevalent in the U.S. and may contribute to discrimination against individuals who do not conform to traditional gender roles. Understanding the attitudes of undergraduate students is of particular interest as they may represent emergent societal views toward gender nonconformity. Methods: We conducted an online survey of Mountain West college students between the ages of 18-24 years to assess perceptions of personal gender conformity using the Traditional Masculinity-Femininity Scale (TMF), endorsement of heteronormative beliefs using the Heteronormative Attitudes and Beliefs Scale (HABS), and explicit tolerance of gender nonconformity on a 7-point Likert Scale. Results: The sample (n = 502) was 84% female and 78% white. Approximately 21% of respondents identified as a sexual minority and 36% identified as liberal or somewhat liberal (27% were conservative). The mean score on the TMF was 5.23 (95% CI: 5.15-5.32), indicating moderate levels of personal gender conformity. The mean HABS scores was 3.31 (95% CI: 3.19-3.43), indicating relatively low endorsement of heteronormative attitudes. TMF and HABS scores were both highest in heterosexual males. Most respondents (73%) were taught traditional gender roles in their childhood home, and 89% had heard negative opinions about nonconformity. The majority (80.6%) of respondents reported that they know someone who displays nonconforming characteristics and 61% said that they associate gender nonconformity with homosexuality. Approximately, 7% reported they had bullied others for not conforming to their gender. Among heterosexuals, 13.6% reported they had been bullied for gender nonconformity as did 42.7% of LGBTQ-identified individuals. Nearly 1-in-4 (23.6%) believed that male cross-dressing is wrong. Nearly 1-in-5 (17.2%) agreed with the statement that those who dress or act like the opposite sex were more likely to be abused or neglected during their development. Conclusion: Students reported relatively low endorsement of heteronormative attitudes and moderate levels of acceptance toward gender nonconforming persons. The sample reflects shifting attitudes when compared with outside data sets.
Nuclear Oncology 2: Scintigrahic Imaging

Nuclear medicine has a major role in the management of malignant tumors. With the developments towards molecular imaging and the technological advancement of scanners providing a fusion of both physiologic and anatomic imaging, it has even become a more integral part of management protocols. This role includes detection of malignant tumors, staging and restaging of the disease, early detection of recurrence, evaluation of the response to therapy, and prediction of the prognosis. Radionuclide diagnosis and therapy for tumors depend on the characteristics of tumors including increased vascularization, increased blood flow, newly proliferated capillaries with more permeable walls, increased metabolic activity of cells, increased energy demand, high density of some common antigens or several specific antigens, and several specific receptors as discussed in the previous chapter.
Féline Fatale: The New Woman as Cat-Woman in Rachilde’s L’Animale

In her analysis of L’Animale (1893) by Rachilde (1860–1953), Nettleton examines the modern cat-woman myth, where women and cats in fiction were often relegated to marginal spaces like rooftops and gutters, with no clear place in urban society. Nettleton discusses the newfound abundance of women in the arts, from painters to Chat Noir cabaret performers. Drawing parallels between feminist theory and animal theory (Haraway, Adams, Donovan), Nettleton analyzes Rachilde’s own self-identification with animals, and cats in particular, as integral to her creative process. A morphing creature that escapes social identity, Rachilde’s figure of the cat-woman transcends the boundaries between man and woman, human and animal, as well as technical and organic. The feline fatale is a part of an urban aesthetic that still clings to its pastoral past. Much like the architectural and proto-cinematic arts of the fin de siecle, L’Animale infuses theriomorphic and technical imagery within the industrial cityscape of fin de siecle France.
Not so right after all? Making sense of the progressive rhetoric of Europe’s far-right parties:

Several newly successful far-right European populist parties have deviated from traditional conservative stances by embracing progressive values such as gender equality, gay rights, religious freed...
What makes an effective grants peer reviewer? An exploratory study of the necessary skills

This exploratory mixed methods study describes skills required to be an effective peer reviewer as a member of review panels conducted for federal agencies that fund research, and examines how reviewer experience and the use of technology within such panels impacts reviewer skill development. Two specific review panel formats are considered: in-person face-to-face and virtual video conference. Data were collected through interviews with seven program officers and five expert peer review panelists, and surveys from 51 respondents. Results include the skills reviewers' consider necessary for effective review panel participation, their assessment of the relative importance of these skills, how they are learned, and how review format affects skill development and improvement. Results are discussed relative to the peer review literature and with consideration of the importance of professional skills needed by successful scientists and peer reviewers.
Surgery for the Hospice Patient: When Is It Appropriate?

Meet Mr. Alexander, a patient with multiple comorbidities who is on hospice. He breaks a hip and later develops a bowel perforation. Explore how to navigate a hospice patient with real surgical needs.
The association between self-declared acute care surgery services and critical care resources: Results from a national survey.

Abstract Purpose We examined differences in critical care structures and processes between hospitals with Acute Care Surgery (ACS) versus general surgeon on call (GSOC) models for emergency general surgery (EGS) care. Methods 2811 EGS-capable hospitals were surveyed to examine structures and processes including critical care domains and ACS implementation. Differences between ACS and GSOC hospitals were compared using appropriate tests of association and logistic regression models. Results 272/1497 hospitals eligible for analysis (18.2%) reported they use an ACS model. EGS patients at ACS hospitals were more likely to be admitted to a combined trauma/surgical ICU or a dedicated surgical ICU. GSOC hospitals had lower adjusted odds of having 24-h ICU coverage, in-house intensivists or respiratory therapists, and 4/6 critical-care protocols. Conclusions Critical care delivery is a key component of EGS care. While harnessing of critical care structures and processes varies across hospitals that have implemented ACS, overall ACS models of care appear to have more robust critical care practices.
Weak States and Terrorist Organizations: A Proposed Model of Intervention

The war on terrorism in the post 9/11 reality brings constant challenges to jurists. One of these challenges deals with terrorist organizations like al-Qaida that build terrorist infrastructure in various parts of the Third World, such as in Africa and the Middle East where the central government is either weak or absent. Be it in parts of Sudan or in Yemen the vast areas that give ample hiding ground for terrorists coupled with a weak government that can’t stop Al-Qaida make them a heaven for terrorists. This article raises the question what can be done in such a scenario? What tools does a government combating al-Qaida have when terrorists find a safe haven in remote parts of the globe far away from the control of a government, which might be sympathetic to the war on terrorism but for geo-political reasons lack the will and means to drive Al-Qaida away. We argue that in a situation where a state does not have the ability to control parts of its territory taken by terrorists which are using it as a base of operation to launch attacks on a third state, this failure to act raises the right of self-defense to the attacked party. When a state loses its sovereignty to a terrorist organization and it cannot fulfill its duties, it forfeits some of the privileges that sovereignty entails. However since this inaction is not a voluntary one, the actions against the terrorist organization thus infringing on the sovereignty of the weak state should be gradual and allow the weak state the opportunity to resume its capacity as a sovereign state. We suggested a list of tactical measures that have a lesser effect on sovereignty and allow the weak state to choose between acting against the terrorist entity or allowing the intervening force to do so on its behalf.
Commentary: Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline.

No abstract available Keywords: Meningioma; Meta-analysis; Noncavernous sinus benign meningioma; SRS; Stereotactic radiosurgery; Systematic review; guidelines.
Rural-Urban Differences in the Labor-Force Impacts of COVID-19 in the United States

COVID-19 has had dramatic impacts on economic outcomes across the United States, yet most research on the pandemic’s labor-market impacts has had a national or urban focus. We overcome this limitat...
The Research of SEIJR Model With Time-Delay Based on 2019-nCov

A global epidemic disease known as the novel coronavirus (2019-nCov) had seriously hit the most area around the whole world causing unpredictable loss of manpower and finance during the past year. Modeling the spread and development of infectious diseases represented by new Coronavirus has become an important part of public health work in the world. Estimation of possible infection population and prospective suggestion of handling spread based on existing data is crucial. In this article, we build a more applicable model called SEIJR with a log-normal distributed time delay to forecast the trend of spreading considering the biology parameters obtained based on Chinese clinical data in Wuhan and the real spread feature of 2019-nCov in Italy. Adopting Particle Swarm Optimization (PSO), we estimate the early period average spreading velocity ( $\boldsymbol {\alpha _{0}}$ ) and implement inversion analysis of time point ( $\boldsymbol {T_{0}}$ ) when the virus first hit Italy. Based on fixed $\boldsymbol {\alpha _{0}}$ and $\boldsymbol {T_{0}}$ , we then obtained the average spreading velocity $\boldsymbol {\alpha _{1}}$ after the area lockdown using PSO. The result shows that it will help address the infection by generating the prediction trends of different $\boldsymbol {\alpha }$ which we considered. Finally, our research applies Logistic regression, Neural Network embedding LSTM layer, which is two representative machine learning algorithms, to directly predict future infection trends and compare the forecast with results yielded by mathematical model adopting differential equations. Not only solved the complex, nondifferentiable equation of the epidemic model, this research also performs well in inversion analysis based on PSO which conveys informative outcomes for further discussion on precautious action. The comparison with the machine learning algorithms shows that the 2019-nCov based epidemic dynamics assumption is reasonable and helpful to the mathematical model, which is better than the data-driven machine learning algorithms. Code can be freely downloaded from https://github.com/Summerwork/2019-nCov-Prediction .
Abstract 38: ERK5 inhibitor XMD8-92 for malignant mesothelioma treatment: A preclinical study

Malignant mesothelioma (MM) is an aggressive cancer in dire need of successful treatment. We are first to demonstrate that Extracellular signal regulated kinase 5 (ERK5) plays an important role in MM pathogenesis (Clinical Cancer Research, 19, 2013). In this study we used genetically manipulated (ERK5 inhibited) MM cell lines to show that MM tumorigenesis is influenced by ERK5. In the present study we used recently discovered specific ERK5 inhibitor (XMD8-92) to show that it regulates MM tumor growth both in vitro and in vivo. First, we show that XMD8-92 inhibits ERK5 phosphorylation in 3 out of 4 MM cell lines showing constitutive activation of ERK5. Next, time and dose dependent study demonstrated significant cytotoxicity of XMD8-92 on 3 different MM cell lines. We also showed that soft agar colony forming efficiency of H2373 MM cells was significantly reduced in response to XMD8-92 treatment. Furthermore, in vivo studies using syngeneic mouse model of intraperitoneal mesothelioma showed that XMD8-92 treatment (50 mg/kg, ip, 1x daily for 3 weeks) resulted in significant decreases in tumor weights as compared to vehicle treated mice. Total and differential cell counts in peritoneal lavage fluid (PLF) were also inhibited by XMD8-92 suggesting the role of inflammation in MM tumor growth and their inhibition by ERK5 inhibitor. Cytokine profile assessment in PLF demonstrated the reduced levels of VEGF and IL-6 in XMD8-92 treated animals as compared to control animals receiving saline. FGF2, MCP-1, G-CSF, KC and RAGE levels were, however, not significantly impacted by the ERK5 inhibition. Taken together these data suggest that ERK5 inhibitor/ERK5 inhibition could be used for inhibiting the growth of MM tumors. Currently we are exploring the role of XMD8-92 alone as well as in combination with chemotherapeutic drugs for the treatment of MM using various mouse models. We are also exploring the role(s) of ERK5 inhibitor in inflammasome regulation by chemotherapeutics. This work is supported by NIEHS RO1 ES021110 and VCC/LCCRO grants. Citation Format: Arti Shukla, Joyce Thompson, Anurag Shukla, Alan Leggett, Maximilian MacPherson, Stacie Beuschel. ERK5 inhibitor XMD8-92 for malignant mesothelioma treatment: A preclinical study. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 38. doi:10.1158/1538-7445.AM2015-38
Adverse Childhood Experiences, Family Functioning, and Resilience in Military Families: A Pattern-Based Approach

Linkages between adverse childhood experiences and long-term consequences in servicemen and servicewomen were examined in relation to family-level resiliency processes predicted to mitigate this link. Using a pattern-based, multi-informant approach, resilience was explored through a systemic lens in relation to family-level processes. Latent family profiles were identified using diverse dimensions of family functioning guided by the circumplex model. Data were collected from parents and their adolescents, age 11 to 18, living in the continental United States (N = 273 military families). Variations in adverse childhood experiences among servicemembers and their partners were related to heterogeneous family functioning typologies (profiles). One adaptive family functioning typology illustrated that a select group of families with higher levels of early adverse experiences evinced adaptive functioning outcomes in multiple domains in adulthood. Implications for examining individual resilience via a family-level process and applications to educational and clinical contexts are discussed in relation to military and nonmilitary families.
Visual information retrieval techniques applied to veterinary radiology

This paper presents an assessment of the difficulties involved in implementing visual information retrieval (VIR) systems for veterinary images such as x-rays. Particularly, we examine cases where the x-ray exchange is of a casual nature, such as x-rays photographed and stored as JPEG images, so that they can be exchanged and shared more readily with other professionals in the field. While this practice is very convenient for the exchange of information between veterinary professionals, the resulting images contain imperfections such as glare, angular distortion, and background noise. These imperfections can become a stumbling block when applying VIR algorithms intended to analyze and process these images.
The impact of dual-market on supply chain configuration for new products

Given a firm’s supply chain network, the key objective of supply chain configuration (SCC) is to determine a subset of supply chain partners to be involved in development, sourcing, production, distribution and support of a new product at the highest level of efficiency and expected responsiveness. Current literature on SCC realises the importance of considering the demand dynamics associated with the new product diffusion (NPD). However, these studies assume one-segment market for new products, a single homogenous consumer segment. Recent research in marketing indicates that such simplification might be fatal because a diverse and significant number of product categories may experience a dual-market structure, namely early and main markets, and generate a different demand dynamics. The objectives of this study are to: (i) develop a hybrid optimisation model, capturing both SCC decisions and the demand dynamics of dual-market NPD process; (ii) based on real-world data for a host of electronic product cate...