cssi/SciSciGPT-SciSciNet huggingface dataset:
The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae.

The Saccharomyces cerevisiae p21-activated kinases, Ste20p and Cla4p, have individual functions but appear to share an essential function(s) as well because a strain lacking both kinases is inviable. To learn more about the shared function, we sought new mutations that were lethal in the absence of CLA4. This approach led to the identification of at least 10 complementation groups designated NCS (need CLA4 to survive). As for ste20 cla4-75 mutants, most ncs cla4-75 double mutants were defective for septin localization during budding. One group, NCS1/RRD1 (YIL153w), did not confer this defect, however, and we investigated its function further. ncs1Δ cla4Δ cells arrested with elongated buds and short mitotic spindles. The morphological defects and lethality were suppressed by mutations that abrogate the cell cycle morphogenetic checkpoint, CDC28Y19F or swe1Δ. The connection to the cell cycle may be direct, as we detected a Cla4p-Cdc28p complex. NCS1 encodes a protein with significant similarity to a mammalian phosphotyrosyl phosphatase activator (PTPA) regulatory subunit for type 2A protein phosphatases (PP2As). Genetic and biochemical evidence suggested that the phosphatase Sit4p is a target for Ncs1p. First, CLA4 and SIT4 were synthetically lethal. Second, Ncs1p and its yeast paralog, Noh1p (Rrd2p), bound to the catalytic domain of Sit4p in vitro, and Ncs1p could be immunoprecipitated with Sit4p but not with another PP2A (Pph21p) from yeast cell extracts. Strains lacking both NCS1 and NOH1 were inviable and arrested as unbudded cells, implying that PTPA function is required for proper G1 progression.
The Impact of Leadership Turnover and Domestic Institutions on International Cooperation

In the context of a noisy, continuous-choice prisoner's dilemma, the authors examine how leadership turnover and domestic institutions affect the depth and reliability of cooperative agreement that...
Playing with fire: an unexpected collaboration

Working with dancers to generate musical material has been the interest of many composers since such technologies became available. My work focuses on a particular kind of dance – a fire dancer – to generate sonic material. Working with a fire dancer in a collaborative environment creates a unique set of difficulties with rewarding outcomes.
Antimicrobial-Coated/Bonded and -Impregnated Intravascular Catheters

OBJECTIVE:To review the literature regarding the prevention of catheter colonization and catheter-related bloodstream infections (CRBIs) with the use of antimicrobial-coated/bonded and -impregnated intravascular catheters.DATA SOURCES:Primary and review English-language literature were identified using MEDLINE (1966–September 2000) pertaining to the key terms antibiotic, antimicrobial, antiseptic, silver, and bonded, coated, impregnated catheters. In addition, textbooks and relevant reference lists were reviewed.DATA EXTRACTION:All articles identified through the data sources were evaluated. Information deemed relevant to the objectives of the review was included.DATA SYNTHESIS:Significant morbidity and mortality are associated with the development of CRBIs. Preventative measures such as modification of these catheters with antimicrobial coating/bonding have produced varying results. Trials evaluating cefazolin, teicoplanin, vancomycin, silver, and chlorhexidine—silver sulfadiazine (C-SS) used for coated/...
Tubuloglomerular feedback is decreased in COX-1 knockout mice after chronic angiotensin II infusion.

Prostaglandins (PGs), produced by two isoforms of cyclooxygenase (COX), COX-1 and COX-2, are important modulators of renal hemodynamics. COX-1 and COX-2 are expressed in the kidney often at distinct sites. Thromboxane (TxA2), PGE2, and prostacyclin (PGI2) are the major PGs in the renal cortex of mice. Acute infusion of the vasoconstrictor ANG II increases COX-2-dependent PGE2 and PGI2. COX-2 is primarily expressed in the macula densa (MD), where several PG synthases are also expressed. We previously showed that MD COX-2 products modulate tubuloglomerular feedback (TGF) in the rat. Genetic deletion of COX-1 enhances COX-2 production of PGs, decreases renal and urinary PGs, and attenuates ANG II-induced hypertension. The present study tested the effects of chronic ANG II infusion on TGF in COX-1 knockout (KO) mice. Basal TGF was similar in COX-1 KO and wild-type (WT) mice. Chronic ANG II infusion increased TGF in WT mice (WT: 9.3 ± 0.7 vs. WT + ANG II: 12.2 ± 1.6 mmHg, P < 0.02). However, chronic ANG II decreased TGF in COX-1 KO mice (KO: 11.4 ± 1.1 vs. KO + ANG II: 8.3 ± 0.6 mmHg, P < 0.01). Pretreatment with the COX-2 inhibitor SC-58,236 in COX-1 KO mice prevented the ANG II-associated reduction in TGF (11.4 ± 1.0 vs. 11.5 ± 0.28 mmHg, not significant). Excretion of 6-keto-PGF2α, the metabolite of PGI2, was increased by ANG II infusion, whereas excretion of TxB2, the stable metabolite of TxA2, was not changed. ANG II infusion increased mean arterial pressure similarly in both WT and KO mice (WT: 93 ± 2 vs. KO: 92 ± 3 mmHg), but not in KO mice pretreated with SC-58,236 (85 ± 2 mmHg). This study shows that COX-1-generated PGs partially mediate ANG II increases in TGF and that COX-2 PGs offset that effect.
A New Mechanism for Attention Direction in Information Management

Information systems can present an enormous amount of information to a user. One of the important issues in the design of the user interface is directing the user's attention to the critical information in a situation, especially when a user's request for information produces an uncertain result. The purpose of this paper is to describe how a unique approach provides a solution to the problem of attention direction while simultaneously representing the database designer's intent to the user to facilitate user/system communication.
Putting the Pieces Together: High-performance LC-MS/MS Provides Network-, Pathway-, and Protein-level Perspectives in Populus

High-performance mass spectrometry (MS)-based proteomics enabled the construction of a detailed proteome atlas for Populus, a woody perennial plant model organism. Optimization of experimental procedures and implementation of current state-of-the-art instrumentation afforded the most detailed look into the predicted proteome space of Populus, offering varying proteome perspectives: (1) network-wide, (2) pathway-specific, and (3) protein-level viewpoints. Together, enhanced protein retrieval through a detergent-based lysis approach and maximized peptide sampling via the dual-pressure linear ion trap mass spectrometer (LTQ Velos), have resulted in the identification of 63,056 tryptic peptides. The technological advancements, specifically spectral-acquisition and sequencing speed, afforded the deepest look into the Populus proteome, with peptide abundances spanning 6 orders of magnitude and mapping to ∼25% of the predicted proteome space. In total, tryptic peptides mapped to 11,689 protein assignments across four organ-types: mature (fully expanded, leaf plastichronic index (LPI) 10–12) leaf, young (juvenile, LPI 4–6) leaf, root, and stem. To resolve protein ambiguity, identified proteins were grouped by sequence similarity (≥ 90%), thereby reducing the protein assignments into 7538 protein groups. In addition, this large-scale data set features the first systems-wide survey of protein expression across different Populus organs. As a demonstration of the precision and comprehensiveness of the semiquantitative analysis, we were able to contrast two stages of leaf development, mature versus young leaf. Statistical comparison through ANOVA analysis revealed 1432 protein groups that exhibited statistically significant (p ≤ 0.01) differences in protein abundance. Experimental validation of the metabolic circuitry expected in mature leaf (characterized by photosynthesis and carbon fixation) compared with young leaf (characterized by rapid growth and moderate photosynthetic activities) strongly testifies to the credibility of the approach. Instead of quantitatively comparing a few proteins, a systems view of all the changes associated with a given cellular perturbation could be made.
A Guide to Earth Science Data: Summary and Research Challenges

Recent growth in the scale and variety of Earth science data has provided unprecedented opportunities to big data analytics research for understanding the Earth's physical processes. An upsurge of Earth science datasets in the past few decades are being continually collected using various modes of acquisition, at different scales of observation, and in diverse data types and formats. Earth science datasets, however, exhibit some unique characteristics (such as adherence to physical properties and spatiotemporal constraints) that present challenges to traditional data-centric approaches. In this article, the authors briefly introduce the different categories of Earth science datasets and further describe some of the major data-centric challenges in analyzing Earth science data.
Terbutaline in the treatment of acute asthma in childhood.

Forty-eight children with known asthma (ranging in age from 2 to 16 years) were studied during an acute attack. Each received either terbutaline or epinephrine subcutaneously in a random double-blind fashion. Measurement of heart rate, respiratory rate, and systemic arterial systolic and diastolic blood pressures and careful clinical assessment of obstruction of the airway were made before and at 15, 30, and 60 minutes after the administration of the drugs. Appreciable and significant clinica] improvement was noted in 19 of the 24 patients in both groups and was of comparable magnitude. A small, but significant, increase in heart rate was noted in those patients requiring only one injection of terbutaline, suggesting that the drug's selectivity for the lung is relative, not absolute. The present study demonstrates that terbutaline is an effective bronchodilator drug in acute childhood asthma.
Constructing Bayesian networks for medical diagnosis from incomplete and partially correct statistics

The paper discusses several knowledge engineering techniques for the construction of Bayesian networks for medical diagnostics when the available numerical probabilistic information is incomplete or partially correct. This situation occurs often when epidemiological studies publish only indirect statistics and when significant unmodeled conditional dependence exists in the problem domain. While nothing can replace precise and complete probabilistic information, still a useful diagnostic system can be built with imperfect data by introducing domain-dependent constraints. We propose a solution to the problem of determining the combined influences of several diseases on a single test result from specificity and sensitivity data for individual diseases. We also demonstrate two techniques for dealing with unmodeled conditional dependencies in a diagnostic network. These techniques are discussed in the context of an effort to design a portable device for cardiac diagnosis and monitoring from multimodal signals.
Redundancy versus lifetime tradeoff analysis for environment monitoring using wireless sensor networks

Recent advancements of microelectronics and network protocol research enable the vast applications of wireless sensor network in industry and home environments. For example, the research in this paper is part of a NASA hydrogen detection to provide early detection of hydrogen leaks in storage facilities and transportation processes. Reliability issues play a vital role to ensure the quality of service of these applications, as well as to maintain the detection and response capabilities. In this paper, we provide a reliability analysis of a wireless sensor network based on the MIL-HDBK-217 reliability prediction model, and we examine the tradeoffs of enhancing the reliability of the network through redundancy of sensor network sleep sets, versus maximizing the energy-based lifetime of the network. An optimal number of sleep sets can be found, based on the given functional failure and the battery power expense models.
A simple extrusion method for the synthesis of aligned silica nanowires using the template of a rigid surfactant mesophase

Long range alignment of silica nanowires has been accomplished by extrusion of a novel surfactant mesophase prior to silica synthesis.
An Unusual P−P Double Bond Formed via Phospha-Wittig Transformation of a Terminal PO Complex

The terminal phosphorus monoxide complex (OP)Mo(N[(t)Bu]Ar)(3), 1 (Ar = 3,5-Me(2)C(6)H(3)), undergoes an O-for-PSiR(3) metathesis reaction with the niobium phosphinidene complex (i)Pr(3)SiPNb(N[CH(2)(t)Bu]Ar)(3), 2, to generate the oxoniobium complex ONb(N[CH(2)(t)Bu]Ar)(3), 3, and the diphosphenido complex (i)Pr(3)SiPPMo(N[(t)Bu]Ar)(3), 4. The structure of 4, as determined by X-ray crystallography, contains a "singly bent" diphosphenido moiety, suggesting that the diphosphenido ligand serves as a 3e(-) donor to a formally d(2) metal center. This bonding characterization was supported by DFT calculations and is unique among known diphosphenido complexes. Diphosphenido 4 was found to react over time to produce products consistent with a bimolecular degradation pathway where the terminal phosphide complex PMo(N[(t)Bu]Ar)(3), 5, serves as a stable leaving group. Mixtures of 4 and PPh(3) were observed to set up an equilibrium (K(eq) = 0.7) between 4, PPh(3), and the products of phosphinidene transfer, 5 and (i)Pr(3)SiP=PPh(3).
Taphonomic applications of georadar

Taphonomic research, particulary in vertebrate paleontology and archaeology, relies on the analysis of geological context of fossils or artifacts. Ground-penetrating radar is an effective high-resolution subsurface imaging technique that can be used not only for locating buried objects (decimeter-scale or larger), but also for visualizing their in situ geological context. The records often reveal sediment deformation structures around a buried target and allow imaging below the water table, often inaccessible by other methods. This paper presents examples, of recent setting (ephemeral inlet channel and active dune) to illustrate the use of georadar in resolving both continuous (geological) and pointsource (three-dimensional objects) features. When complemented with excavations or exposures subsurface images become an important part of taphonomic investigation by paleontolgists and archaeologists.
A Case of Gynandromorphism in Amblyomma imitator (Acarina: Ixodidae

Various instances of gynandromorphism in ixodid ticks have been reported, and the subject has been reviewed by Campana-Rouget (1959). In most cases the left side of the body has female characters and the right side, male characters.
Comparison of same-day sequential anterior and posterior spinal fusion with delayed two-stage anterior and posterior spinal fusion

STUDY DESIGN This was a retrospective review. Short-term outcomes were compared based on two different surgical techniques. OBJECTIVES To determine the safety, efficacy, and cost effectiveness of two different surgical techniques of anterior and posterior spinal fusion for pediatric patients with spinal deformity. SUMMARY OF BACKGROUND DATA Brown et al, Floman et al, and Bradford et al have reported on combined anterior and posterior spine fusions with a 1-2-week recovery period between stages. However, advances in surgical and anesthetic techniques combined with the prohibitive cost of prolonged hospitalization and theoretical advantages in pulmonary function and nutrition have led to increasing use of combined anterior and posterior spinal fusion under one anesthetic. METHODS The authors reviewed records and radiographs of patients with pediatric spinal deformities who underwent anterior spine fusion/posterior spine fusion and instrumentation performed by the senior author (HAK) at one institution. RESULTS Same-day sequential anterior spine fusion/posterior spine fusion resulted in less blood loss (575 +/- 275 ml; P < or = 0.0045), shorter hospital stay (8.00 +/- 2.68 days; P < or = 0.0001), and reduced hospital costs ($18,762 +/- $4,925; P < or = 0.0001). Operative time and complication rate were not affected. CONCLUSIONS In selected patients with pediatric spinal deformity, experienced spinal surgeons can reduce blood loss, hospital stay, and costs by performing anterior and posterior spinal fusions sequentially under one anesthetic.
Electromagnetic Radiation Outbursts from the Collision of p/ SHOEMAKER-LEVY-9 Comet with Jupiter

The forthcoming collision by debris of P/Shoemaker-Levy 9 comet with Jupiter during the week of July 18, 1994 has generated considerable scientific and public interest. This collision may release an amount of energy ranging from 1025-1031 ergs in the Jovian atmosphere. Two possible phenomena associated with this event are described in this Letter to the Editor. The first one is the likely display of deformed Jovian magnetic field lines as the comet interacts with the Jovian magnetosphere. The second one is electromagnetic radiation outbursts during comet explosions over a wide frequency range from radio up to gamma ray emissions. If relativistic electrons with energies up to ~ 1000 MeV could be produced during comet explosions, then synchrotron radiations with frequencies from radio up to infrared range could be detectable. Hard X-rays and gamma rays could be produced by bremsstrahlung and inverse Compton processes. Since one cannot exclude the possible transient presence of relativistic electrons with Lorentzγ factor ≳ 2 × 106, synchrotron radiation component might even be extended into gamma ray frequency range during intermittent short time intervals.
Considerations in biomarker development for neurodevelopmental disorders.

Purpose of reviewDespite significant progress in recognizing the biological bases of autism spectrum disorder, diagnosis and treatment rely primarily on subjective evaluation of behavior. This review highlights the challenges unique to neurodevelopmental disorders that have limited biomarker develop
Novel Secure Multicast Protocol Based on Public Cryptosystem

This paper proposes a secure and efficient multicast protocol for Internet based on public cryptosystem, in which the key management only occurs in the local subgroups. The protocol takes advantage of multicast backbone(Mbone) topology. It maintains the scalability and efficiency of Mbone.
Cloning and expression of full-lengthTrichoderma reesi cellobiohydrolase I cDNAs inEscherichia coli

The process of converting lignocellulosic biomass to ethanol via fermentation depends on developing economic sources of cellulases.Trichoderma reesei cellobiohydrolase (CBH) I is a key enzyme in the fungal cellulase system; however, specific process application requirements make modification of the enzyme by site-directed mutagenesis (SDM) an attractive goal. To undertake SDM investigations, an efficient, cellulase-free host is required. To test the potential ofEscherichia coli as a host, T.reesei CBH I cDNA was expressed inE. coli strain GI 724 as a C-terminal fusion to thermostable thioredoxin protein. Full-length expression of CBH I was subsequently verified by molecular weight, Western blot analysis, and activity on soluble substrates.
Nonlinear Regression on Riemannian Manifolds and Its Applications to Neuro-Image Analysis

Regression in its most common form where independent and dependent variables are in ℝn is a ubiquitous tool in Sciences and Engineering. Recent advances in Medical Imaging has lead to a wide spread availability of manifold-valued data leading to problems where the independent variables are manifold-valued and dependent are real-valued or vice-versa. The most common method of regression on a manifold is the geodesic regression, which is the counterpart of linear regression in Euclidean space. Often, the relation between the variables is highly complex, and existing most commonly used geodesic regression can prove to be inaccurate. Thus, it is necessary to resort to a non-linear model for regression. In this work we present a novel Kernel based non-linear regression method when the mapping to be estimated is either from Mi¾?ℝn or ℝni¾?M, where M is a Riemannian manifold. A key advantage of this approach is that there is no requirement for the manifold-valued data to necessarily inherit an ordering from the data in ℝn. We present several synthetic and real data experiments along with comparisons to the state-of-the-art geodesic regression method in literature and thus validating the effectiveness of the proposed algorithm.
Towards a Holistic Biomedical Information Platform for Primary and Secondary Use Settings.

BACKGROUND Clinical information is often used for biomedical research. Data warehouses can help providing researchers with data and the opportunity to find eligible participants for clinical trials. OBJECTIVES To define an information platform for healthcare and biomedical research based on requirements by clinicians and researchers. METHODS Interviews with clinicians, researchers, data privacy officers, IT and hospital administration combined with a questionnaire sent to 60 medical departments at our hospital were conducted. RESULTS Resulting requirements were grouped and a platform architecture was designed based on the requirements. CONCLUSION Requirements lead to a single platform supporting both, patient care and biomedical research.
UNUSUAL GENOME ORGANIZATION OF NEUROSPORA CRASSA

Publisher Summary This chapter examines the unusual genome organization of Neurospora crassa. The genome of the fungus Neurospora crassa was analyzed and found to have a sequence complexity relative to E. coli of 2 × 107 BP. The genome is composed of 90% unique, 8% repetitive, and 2% fold-back sequences. The complexity of the repetitive component is 15,400 BP with a repeat frequency of 140. Genetic evidence indicates that many nonlinked structural genes are coordinately and positively controlled. The chapter discusses the organization of the repetitive components in the genome because they may play a role in gene regulation. A variety of studies indicate that the repetitive sequences are organized in stretches 10,000 BP or longer. At most, only 2–3% of the unique sequences are adjacent to the repetitive sequences at fragment lengths up to 10,000 BP. Ribosomal DNA represents 5–6% of the total DNA and about 80% of the repetitive component. As the rDNA units are believed to be tandemly repeated on a single chromosome, as is the case in yeast, their clustering can largely account for the large repetitive stretches and lack of interpersion of the repetitive sequences. These results indicate that Neurospora crassa does not conform to either the short-period or long-period interspersion pattern for repetitive sequences seen in other eucaryotes.
Paul Would Be Proud: The New Testament and Jewish–Gentile Respect:

The article analyzes Jewish–Catholic relations with respect to New Testament interpretation, the apostle Paul, and theology. In the New Testament era, Paul promoted God’s openness to Gentiles. In r...
PWM Based Sensing and Control of Magnetic Bearings

This paper develops a PWM Based Position Sensing method for motion control of active magnetic bearings. A practical method to determine the rotor position in terms of rotor-stator magnetic properties was investigated. An analog signal processing circuit which conditions the PWM voltage and current signals is used to implement the method. Analog biquad band pass filters, as well as low pass filters, demodulators, isolators and dividers were built. Preliminary tests were conducted using a four pole homopolar magnetic bearing by manually varying the rotor position and measuring the effectiveness of the signal processing module. The closed loop magnetic bearing motion control based on PWM sensing module was simulated using Matlab/Simulink. The simulation model includes 4-axis radial magnetic bearings with the dynamics of a high speed flywheel. A PD controller along with notch filters and lead compensators were employed in the closed loop control system. The simulation results demonstrated converged orbit trajectories of the rotors, which proved the effectiveness of the sensing scheme and the control strategy.
Sleep, Sleep Disorders, and Stress

Sleep appears to be an important element in maintaining equilibrium or homeostasis, which is vital for the survival of living organisms. In this article, we review the association between sleep, sleep disorders, and stress, which has been defined as a state of disharmony, or threatened homeostasis.
Meeting overall reliability requirements for heats of steel: A case study

ABSTRACTIn this case study, we examine the reliability of a device whose material was produced over several heats, where the quality metric of the material is the content of a certain element in the material. The analyses revealed a number of issues, including rounded data values as well as periodicity and tilting in the two dimensions of the production process. Novel analysis features include non-standard estimation of certain variance components, and combining several tolerance intervals based on optimization criteria. The results of the analysis were useful to both the customer and supplier of the material.
Etching the Borders of Arbitration Agreement: the Group of Companies Doctrine in International Commercial Arbitration under the U.S. and Turkish Law

In the 21st Century, the commerce is not confined to the boundaries of any single-nation state. Hence, we have been witness to the transactions and disputes involving multiple parties and legal systems. Assuming that you are an in-house counsel in an MNE. Do you ever wonder whether the parent or sister companies' counsel or the opposing counsel may make contact with you about the arbitral proceedings that your client has never agreed on in the first place? Is it possible whether the non-signatory parties are bound by or benefit from the arbitration agreement, and what could be the possible legal grounds given the doctrine of privity of contract? This article discusses one of these grounds, the group of companies doctrine, in the context of Turkish and US legal systems comparatively and explores its applicability in light of precedents.
Should You Screen for and Manage Depression in Patients With a Recent Acute Coronary Syndrome

Nieuwsma and colleagues' systematic review summarizes the evidence for the diagnostic accuracy of depression screening tests and management strategies for patients with acute coronary syndrome. The...
Articulating displacement: Sierra Leonean Muslim dress practice and the aesthetics of negotiation:

In this paper, I examine the spatial and emotional poetics of dress practices deployed by Sierra Leonean Muslim women living in the Washington, DC metropolitan area as they navigate the complexity of life lived in the diaspora. Focusing on the way women utilize sartorial expression to reject or accept imposed moral regimes, I show how dress practices are part of a repertoire of tactics used to challenge displacement, express belonging, and enact pious presence in public venues. In so doing, I illustrate the way differing opinions about stylistic choices reassemble and rearticulate the strategic ways that Sierra Leonean women distinguish themselves, create personal and public subjectivities, and embrace or challenge dominant, and at times imposed, rules of propriety and morality in their everyday lives.
Resource asymmetry and property rights in agricultural drainage systems: Implications for collective action

Scholarly work on examining how property rights affect incentives for collective action in common-pool resource management has benefited immensely from the property-rights analytical scheme proposed in the seminal work of Schlager & Ostrom (1992). Here we apply this scheme to agricultural drainage systems, conceptualizing them as a common-pool resource held in a private property ownership regime and exhibiting asymmetric dilemmas. We propose a property rights analytical scheme to suit the asymmetry of incentives in drainage systems, while examining how drainage management institutions allocate bundles of property rights and how property rights interact to affect incentives for collective action. Unlike Schlager and Ostrom (1992), we find that property rights are not cumulatively bundled, and that having land held in private decouples use rights from physical access rights. In addition, the existence of complementary institutional mechanisms, one landowner-driven and the other government-driven, can provide collective action incentives.
Learning from the unexpected: Statistics and uncertainty in massively scalable online laboratories (MSOL)

Reasoning about unexpected outcomes is crucial to scientific exploration and STEM education. To stimulate conversations about these outcomes, we integrated noise characteristics and uncertainty into the framework of Massively Scalable Online Laboratories (MSOLs), which provide a collaborative and interactive online environment for education. The MSOL approach reduces a physical experiment to a set of states and displays it in an interactive environment. With the approach described here, those stages exhibit noise characteristics and nondeterministic outcomes. As a demonstration, we successfully recorded and displayed an example experiment, which contains quantum noise and limited repeatability. We thus display experiments more realistically and lead students towards a deeper understanding of the physical reality by evoking their curiosity about the variation of the displayed outcomes.
Client-serve yourself

The Office of Information Technology at California State University, Fullerton is responsible for campus administrative mainframe and programming support, as well as for all mainframe applications such as the student records and financial accounting systems. Two campus organizations, University Extended Education and the Office of Analytical Studies rely heavily on the timeliness and accuracy of administration and student record data. These organizations have identified process improvements that are best met by client/server database applications. Due to limitations in the universityâ€™s Office of Information Technology support capabilities (budgetary and legacy system related), both University Extended Education and Analytical Studies have opted for internal database development while still relying on the Office of Information Technologyâ€™s mainframe data. This approach has resulted in increased local capabilities without the uncertainties related to working within an overloaded campus-wide Information Technology organization. Whether this approach is advantageous from an enterprise perspective remains to be seen.
Disability Studies and Art Education

This article promotes the field of disability studies as a valuable resource for expanding art education’s concept of disability and as a promising venue for interdisciplinary dialogue. While art education has persistently supported special education since its inception, disability advocacy has advanced in the past two decades toward self-awareness, self-reliance, and selfexpression. The article demonstrates how disability studies, as the academic manifestation of this trend, can critically elaborate disability discourses in art education, such as those which espouse special education and the uncritical use of pejorative disability metaphors. The article concludes by exploring possibilities for art education researchers to contribute to disability studies and to collaborate on research as an interdisciplinary project to advance both fields.
In-vivo analysis of serum-borne growth factors in developing co-twinned fetuses.

Double-muscled fetuses develop more muscle fibers than normal-muscled fetuses. To exam- ine whether serum growth factors modulate muscle development in cattle, twin pregnancies were induced in eight Holstein heifers using embryos from Belgian Blue and Holstein genetics representing heavy (HM) and light (LM) muscled cattle, respectively. Twin combinations were 1) two pairs of Belgian Blue fetuses that were designated as HM (HM), 2) two pairs of Holstein fetuses that were designated as LM (LM), and 3 ) four pairs of mixed fetuses; the four Holstein fetuses were designated as LM (HM) and the four Belgian Blue fetuses were designated as HM (LM). Pregnancies were terminated at 175 rf: 5 d after conception and fetuses, with evidence of vascular anastomosis, were dissected. Carcass weights were greatest (P HM (LM) > LM (HM) = LM ( LM) ( P HM (HM) > LM (HMI = LM (LM) (P < .05). These data show that the presence of a co-twinned fetus with a lower genetic propensity for muscle development reduces the capacity of heavily muscled fetuses to develop muscle mass by 175 d after conception and strongly support the idea that blood-borne factors regulate muscle hypertrophy in fetal cattle.
VEGFR and PDGFR: Their Targeting in Liver Cancer

Pro-angiogenic factors such as bFGF, VEGF, and PDGF play a significant role in the invasion, metastasis, and neovascularization of hepatocellular carcinoma (HCC) cells. The expression levels of VEGFR, FGFR, and PDGFR along with the expression of their respective ligands are elevated in HCC. Increased expression levels of bFGF, not acidic FGF, are observed in HCC patients showing capsular infiltration of tumorous cells. Overexpressed VEGF and VEGFR are correlated to progression, angiogenesis, metastasis, tumor recurrence, and poor prognosis in HCC patients. Overexpressed levels of PDGF are associated with an increase in the metastatic potential of HCC. In this chapter, I will discuss VEGF and PDGF roles in metastatic properties of HCC.
Deep Beacon: Image Storage and Broadcast over BLE Using Variational Autoencoder Generative Adversarial Network.

This paper describes Deep Beacon which uses a set of cheap, low-power, storage-constrained Bluetooth Low Energy (BLE) devices to beacon (i.e. broadcast) a color image over a very long period (months, as opposed to days or weeks). The system employs deep neural network image encoder to encode a given input image and generates an extremely compact representation (as small as 10 bytes) of the image. At the receiver end, another deep neural network decoder runs on a mobile device which decodes (i.e. generates) the original image from the BLE broadcast messages. We evaluate Deep Beacon's performance using hand-written digit images and different types of RGB images that contain objects such as birds, flowers, and traffic signs. We empirically determine the tradeoffs between the system lifetime and the quality of broadcast images, and determine an optimal set of parameters for our system, under user-specified constraints such as the number of available beacon devices, maximum latency, and life expectancy. We develop a smartphone application that takes an image and user-requirements as inputs, shows previews of different quality output images, writes the encoded image into a set of beacons, and reads the broadcasted image back. Our evaluation shows that one beacon device is capable of broadcasting high-quality images (90% structurally similar to original images) for a year-long continuous broadcasting, and both the lifetime and the image quality improve when two beacons are used.
How metaphorical framings build and undermine resilience during change: A longitudinal study of metaphors in team-driven planned organizational change

Change is a constant feature of organizing and one that requires resilience, or the ability to effectively face challenges. Although research demonstrates important findings about resilience during chaotic change like crises, less is known about resilience in mundane situations like planned change. This study explores team-driven planned organizational change, offering insights about how team members metaphorically frame change how their framing fluctuates over time relative to perceptions of team success. Our three theoretical contributions extend theory about metaphors and organizational change, showing how negative framings of change are endemic to teams, regardless of perceived success; generate knowledge about resilience in organizing by showing how metaphors both build and undermine resilience; and extend applied theory about stakeholder participation in bureaucratic organizations.
Consumer welfare and climate change in Greenland

Abstract This manuscript aims to assess the potential impact of climate change on consumer welfare in Greenland, an arctic economy that has been historically affected by climate variation. Three proxies for climate change: (i) annual mass change anomaly of the ice cap, (ii) annual temperature anomalies, and (iii) annual heating degree days anomalies are used to test the hypothesis that climate is a potential determinant of consumer expenditure. The Quadratic Almost Ideal Demand System, in its original specification, is used to test this hypothesis. The empirical analysis, supported by Granger-causality tests, shows that the annual mass change anomaly of the ice cap is a statistically and economically significant determinant of consumption of non-durable goods in Greenland. A counterfactual analysis predicts that climate change could have decreased the wealth of consumers with an aggregate cumulative social welfare loss of 2010-US$ 21.63 million between 2003 and 2017.
Supporting Inclusive Teaching in Introductory College Physics

Even among the sciences, physics stands out as an unusually White- and male-dominated field. The American Institute of Physics (AIP) reports that only 19% of physics faculty are women, and less than 6% of physics faculty are African American or Hispanic. Particularly for female students, the transition from high school to a college major in physics has been identified as the most important point of attrition. As such, undergraduate physics education is a critical juncture where these trends can be interrupted. We approached this problem by using teaching strategies intended to promote inclusiveness in a calculus-based, introductory college physics course, a key requirement in many STEM majors and a gateway to the undergraduate physics major. Proponents of inclusive teaching strategies argue that using such strategies will benefit all students, particularly those from marginalized groups, increase the diversity of physics majors, and ultimately contribute to a more diverse community of physicists.
TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ.

The modulation of GLI2, an oncogenic transcription factor commonly upregulated in cancer, is in many cases not due to genetic defects, suggesting dysregulation through alternative mechanisms. The identity of these molecular events remains for the most part unknown. Here, we identified TFII-I as a novel repressor of GLI2 expression. Mapping experiments suggest that the INR region of the GLI2 promoter is necessary for GLI2 repression. ChIP studies showed that TFII-I binds to this INR. TFII-I knockdown decreased the binding of NELF-A, a component of the promoter-proximal pausing complex at this site, and enriched phosphorylated RNAPII serine 2 in the GLI2 gene body. Immunoprecipitation studies demonstrate TFII-I interaction with SPT5, another pausing complex component. TFII-I overexpression antagonized GLI2 induction by TGFβ, a known activator of GLI2 in cancer cells. TGFβ reduced endogenous TFII-I binding to the INR and increased RNAPII SerP2 in the gene body. We demonstrate that this regulatory mechanism is not exclusive of GLI2. TGFβ-induced genes CCR7, TGFβ1 and EGR3 showed similar decreased TFII-I and NELF-A INR binding and increased RNAPII SerP2 in the gene body post-TGFβ treatment. Together these results identify TFII-I as a novel repressor of a subset of TGFβ-responsive genes through the regulation of RNAPII pausing.
Of Law School Rankings, Disparity, and Football

U.S. News & World Report recently announced its intention to debut its new ranking measuring the scholarly impact of law schools’ faculty members in March 2021. In producing the ranking, U.S. News & World Report has collaborated with William S. Hein & Co. Inc, which specializes in distributing legal periodicals, to “link the names of each individual law school’s faculty to citations and publications that were published in the previous five years and are available in HeinOnline, an online database with more than 2,600 legal periodicals.” From this data, U.S. News & World Report plans to create and publish a “comprehensive scholarly impact ranking of law schools.” This new ranking of scholarly impact is as interesting as it is problematic. In this Article, I will unpack a few of the problems inherent in the newly proposed ranking of scholarly impact. Because I am starved for sports in this post-COVID-19 world, I will do so through the analogy of the football penalties these changes carry. Part I describes what rankings of law schools should do and where they fall short. Part II examines the potential impacts of the proposed U.S. News & World Report scholarly impact rankings, focusing on the inequalities they are sure to perpetuate. Part III continues by discussing who rankings of law schools are for—or who should they be for. Finally, this Article concludes with suggestions about how scholarly impact rankings could be improved, and if not, I suggest that they should be ignored.
Do microscopic surgical margins matter for primary gastric gastrointestinal stromal tumor

Abstract Background Although tumor size and mitotic rate are established prognostic factors for worse survival in patients undergoing surgical resection for gastric gastrointestinal stromal tumors, the impact of microscopic margins, or R1 resection, is not completely established. Methods Patients who received no neoadjuvant therapy and underwent surgical resection for stage I to III gastric gastrointestinal stromal tumors were identified from the 2010 to 2013 National Cancer Database and divided into 2 cohorts, R0 and R1 resections. Cox proportional hazards ratio and Kaplan Meier survival estimates were utilized to analyze 5-y overall survival. Results Of 2,084 patients, those with R1 resection (57, 2.7%) were more likely to have tumors >10 cm (28.1% vs 11.9%, odds ratio 3.51, P = .017) and stage III disease (26.3% vs 11.2%, odds ratio 2.26, P = .047). Although margin status was associated with higher risk tumors, it was not associated with receipt of adjuvant therapy. After multivariate Cox regression, R1 and R0 patients did not have a difference in 5-y overall survival (82.5% vs 88.6%, hazards ratio 1.26, P = .49). When stratified by stage of disease, there remained no difference in survival across all stages when comparing R1 and R0 patients. Conclusion Positive microscopic margins are uncommon but do not appear to impact survival outcomes in patients with resected localized gastric gastrointestinal stromal tumors.
Strategies of improving lesion detection in wide-angle digital breast tomosynthesis (DBT) with angular dose distribution and detector design

Cancerous masses are more conspicuous in wide-angle digital breast tomosynthesis (DBT) due to better depth resolution and tissue separation, while the detection of subtle microcalcifications (MC) is challenging. This study aims at providing guidance for a new DBT system design to enhance lesion detection through variable angular dose image acquisition and improved detector performance. Digital breast phantoms were generated, and projection images were simulated using the FDA VICTRE tool 1. Simulated masses and clusters of MC were inserted at different locations of the digital breast phantom. Projection images were simulated with 28 kVp W/Rh energy spectrum, 200 μm thick amorphous selenium (a- Se) direct active matrix flat panel imager (AMFPI), and 50° angular range with 25 views. The impact of a-Se detector performance, i.e., complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) versus AMFPI, with different electronic noise and pixel pitches, was investigated. Even and uneven angular dose distribution schemes (ADS) were designed to test the combined effect of image acquisition setting and detector performance on lesion detection. 2D Filtered Channel observer (FCO) and 3D Channelized Hotelling observer (CHO) were employed to evaluate lesion detectability under different scenarios. The results demonstrated the improvement of direct conversion CMOS APS on the detectability of small MC clusters by reducing FSM, improving DQE at a lower dose, and improve the sharpness of reconstructed MC. The uneven dose distribution benefits the detection of MC without compromising mass detection in FBP reconstructed volumes with slice thickness filter for wide angle DBT.
Antitrust Law: Economic Theory and Common Law Evolution [Book Review]

Professor Keith Hylton provides a timely discussion of the most important doctrines of modern antitrust. Underlying his discussion is the thesis that antitrust can perhaps be best understood through the lens of federal common law. This book review begins by discussing how Professor Hylton's book differs from other books in the field, what topics it covers, and who might profitably read the book. The bulk of the review provides a perspective on the book. On the positive side, Hylton has written a lucid text that fruitfully analyzes antitrust from both a legal and a traditional economic perspective. The review's critique, however, is two-fold. First, while the book does initially lay out some of the limitations of the neoclassical economic paradigm, it ends up not paying sufficient attention to new research in economics that casts doubt on the plausibility of traditional Chicago School law and economics. Second, Professor Hylton ultimately does not take advantage of several opportunities to critique the limitations of the common law in shaping antitrust and thus suggest how competition law might develop in the future. In the end, Antitrust Law is an extremely versatile, valuable and highly recommended book. It is an excellent text for readers who wish a cogent description of antitrust as an evolving form of common law, peppered with an insightful discussion of traditional law and economics. Those wishing sustained engagement with cutting-edge economics research or the articulation of a vision for the future of antitrust, however, will be left wanting more. Some readers might wish that Professor Hylton could offer a more critical perspective on neoclassical economics as well as on the limitations of the common law in setting competition policy. Doing so would have permitted him to address head on some of the most vibrant controversies facing antitrust today. Instead, he has preferred to weave a compelling narrative of antitrust's evolution.