cssi/SciSciGPT-SciSciNet huggingface dataset:
Clinical Evaluation of Hypnotic Drugs: Contributions from Sleep Laboratory Studies

The most thorough and clinically relevant approach to hypnotic drug evaluation is one that balances the strengths and weaknesses of clinical trials and sleep laboratory evaluations. Advantages of clinical trials include the ability to evaluate large numbers of subjects and specific target groups and to thoroughly assess and quantify a drug's side effects, whereas sleep laboratory studies are very limited in all of these areas. Sleep laboratory studies however provide a rigorous, precise, and comprehensive profile of a drug's activity since there is more control over experimental variables and measurements are objective as well as continuous throughout the night. These benefits offset the shortcomings of clinical trials, which include a lack of objective measurements, less control over experimental variables, failure to evaluate a drug's effectiveness with continued use, and inattention to drug interaction and withdrawal effect. Several basic principles derived from sleep laboratory findings have been incorporated into both the clinical trials and sleep laboratory evaluations recommended in the new FDA Guidelines for the Clinical Evaluation of Hypnotic Drugs. These principles include provision for adequate baseline and withdrawal periods, use of multiple consecutive drug nights to assess a drug's effectiveness with continued use, and inclusion of an adequate washout period when a cross-over design is used. The guidelines do not emphasize either clinical trials or sleep laboratory studies at the expense of each other, but rather stress their complementary utilization.
Activity loss and the onset of depressive symptoms: do some activities matter more than others?

Objective This study continues an investigation into the role of decline in performance of valued life activities in the development of depressive symptoms among persons with rheumatoid arthritis (RA). We examined whether declines in specific types of activities are important in the onset of depressive symptoms or whether the important factor is simply the overall burden of activity decline. Methods Data from a longitudinal study of persons with RA, for which individuals are interviewed annually, were used. Two analyses (n = 344 and 310) were conducted because of differences in the way life activities were assessed over time. Each analysis covered 4 interviews (1989–1992 and 1995–1998). Analyses were structured so that the decline in performance of life activities clearly preceded the development of depressive symptoms. The outcome variable was the presence of depressive symptoms at time 4; primary independent variables were activity decline between time 2 and time 3. Individuals with high levels of depressive symptoms prior to time 4 were excluded from the analyses. Results In both analyses, total decline in performance of life activities was an important predictor of subsequent high levels of depressive symptoms. However, some activity domains were more closely linked to the onset of new depressive symptoms than others. In particular, declines in the ability to perform recreational activities and engage in social interactions were linked to the onset of new depressive symptoms. Conclusion Declines in the ability to engage in recreational activities and social interactions appear to significantly increase the risk of new depressive symptoms. These findings can give direction to both clinical inquiries into patients' functioning and interventions intended to enhance functioning.
Simultaneous in-situ monitoring of parallel polymerization reactions using light scattering; a new tool for high-throughput screening

A recently introduced technique, simultaneous multiple sample light scattering (SMSLS), was used to monitor parallel polymerization reactions in situ. SMSLS is designed for real-time, high-throughput screening and provides a time-dependent light scattering signature for each reaction, which contains both qualitative and semiquantitative information. Qualitatively, the signature immediately indicates whether the reaction occurs or not, whether there is an initial lag period, and how long the reaction takes until it stops. The signature also provides estimates of the reaction rate and weight average molecular mass Mw, and its shape can help identify mechanistic aspects, for example, controlled versus free radical polymerization, presence of impurities, etc. The method is inherently adapted to small sample volumes and requires no special sample preparation or postpolymerization characterization. The demonstration here involved the free radical polymerization of acrylamide under varying conditions and should ...
Chemistry of the phenoxathiins IV. Synthesis of 9-substituted 1 -azaphenoxathiins

In an extension of recently reported syntheses of the I-azaphenoxathiin nucleus as well as several 7-substituted analogs, the synthesis of several 9-substituted members of this series is now reported. In addition, the first 13C-nmr spectral evidence of an interaction between a sulfur atom and the oxygen of an ortho-nilro group which has been previously observed only in X-ray erystallographic studies is also described. The possible consequences of this interaction on the reaction pathway leading to the cyclization of the 9-substituted J-azaphenoxathiin nucleus is also presented.
Conversion of cellulose to glucose and levulinic acid via solid-supported acid catalysis

Abstract Cellulose is hydrolyzed to glucose, which is further converted to levulinic acid in the presence of surface-supported Bronsted and Lewis acid catalysts. Nafion catalysts, in particular, have the potential to be recycled or applied to a continuous flow reactor for the synthesis of these biofuel precursors.
Socioeconomic status and child growth in rural Bolivia

This study describes the effect of socioeconomic status on the growth of school‐aged rural Aymara children in the highlands of Bolivia, Families were divided into two occupation groups—merchant‐professionals and farmers. Children from merchant‐professional families were found to be significantly taller, heavier and fatter than children from farming families. Growth of children in the farming families was significantly related to the number of animals owned by the family. Within the total sample, parental education and ability to speak both Spanish and Aymara are positively associated with measures of child growth; but when the two occupation classes are analyzed separately, there is some indication that these socioeconomic variables are negatively associated with growth among children from farming families. These findings indicate that measures of socioeconomic status can be useful indicators of nutritional status in community level studies, but that care must be taken in choosing these indicators.
Extremum and variational principles for elastic and inelastic media with fractal geometries

This paper further continues the recently begun extension of continuum mechanics and thermodynamics to fractal porous media which are specified by a mass (or spatial) fractal dimension D, a surface fractal dimension d, and a resolution lengthscale R. The focus is on pre-fractal media (i.e., those with lower and upper cut-offs) through a theory based on dimensional regularization, in which D is also the order of fractional integrals employed to state global balance laws. In effect, the global forms of governing equations may be cast in forms involving conventional (integer-order) integrals, while the local forms are expressed through partial differential equations with derivatives of integer order but containing coefficients involving D, d and R. Here we first generalize the principles of virtual work, virtual displacement and virtual stresses, which in turn allow us to extend the minimum energy theorems of elasticity theory. Next, we generalize the extremum principles of elasto-plastic and rigid-plastic bodies. In all the cases, the derived relations depend explicitly on D, d and R, and, upon setting D = 3 and d = 2, they reduce to conventional forms of governing equations for continuous media with Euclidean geometries.
Approximate analytical relations for radiative recombination of Br-atoms by free-bound transitions

Abstract Simple analytical expressions are derived for the emission intensity produced by the recombination of Br-atoms by free-bound transitions for optically thin media and for arbitrary optical depth. It is shown that the radiative free-bound transitions can formally be described by an effective upper-state population which is proportional to the collision-rate density at a relative velocity corresponding to the wavenumber of the transition considered. An analytical expression is given for the rate coefficient of the two-body radiative recombination, which is valid within 5% for temperatures up to 2500°K.
Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue

Abstract Proteolytic removal of amino-terminal octapeptides from mitochondrial intermediate proteins is a required step for a subgroup of nuclear-encoded mitochondrial precursors and is specifically catalyzed by mitochondrial intermediate peptidase (MIP). We recently reported the purification of MIP from rat liver and showed that the enzyme is a monomer of 75 kDa. We now report the sequence of a full-length rat MIP cDNA. This cDNA codes for a protein of 710 amino acids, including an amino-terminal mitochondrial leader peptide of 33 residues. The region surrounding the mature MIP amino terminus shows a cleavage site typically recognized by the general mitochondrial processing peptidase (MPP). In vitro synthesized MIP precursor is cleaved to mature MIP by purified MPP, and thus MIP is not required for its own proteolytic maturation. Comparison of the deduced MIP sequence with other sequences in the GenBank data base reveals two important similarities. The first is to a sequence encoding a putative MIP homologue in the recently reported sequence of yeast chromosome III. The putative yeast protein is predicted to be 712 amino acids long and includes a putative 23-residue mitochondrial leader peptide also with a MPP processing site. It shows 47% similarity and 24% identity to rat MIP. The second similarity is to members of a subfamily of metallopeptidases that includes rat metalloendopeptidase EC 3.4.24.15 and two bacterial proteases, oligopeptidase A and dipeptidyl carboxypeptidase. A region of greater than 50% similarity over 400 residues between MIP and these proteins is centered around the sequence motif HEXXH, typical of zinc metallopeptidases.
Pattern of nucleotide substitution and divergence of prophenoloxidase in decapods.

Abstract Despite the unprecedented development in identification and characterization of prophenoloxidase (proPO) in commercially important decapods, little is known about the evolutionary relationship, rate of amino acid replacement and differential selection pressures operating on proPO of different species of decapods. Here we report the evolutionary relationship among these nine decapod species based on proPO gene and types of selective pressures operating on proPO codon sites. Our analyses revealed that all the nine decapod species shared a common ancestor. The mean percentage sequence divergence at proPO gene was 34.4 ± 0.6%. Pairwise estimates of nonsynonymous to synonymous ratio ( ω ) for Homarus americanus–H. gammarus is greater than one, therefore indicating adaptive evolution (functional diversification) of proPO in these two species. In contrast, strong purifying selection ( ω ω value ( ω = 0.15 ± 0.3) than the distantly related species pairs ( ω = 0.0075 ± 0.005). These discrepancies could be due to higher fixation probability of beneficial mutation in closely related species. Maximum likelihood-based codon substitution analyses revealed a strong purifying selection operating on most of the codon sites, therefore suggesting proPO is functionally constrained (purifying selection). Codon substitution analyses have also revealed the evidence of strong purifying selection in haemocyanin subunits of decapods.
Feature Centrality and Conceptual Coherence

Conceptual features differ in how mentally tranformable they are. A robin that does not eat is harder to imagine than a robin that does not chirp. We argue that features are immutable to the extent that they are central in a network of dependency relations. The immutability of a feature reflects how much the internal structure of a concept depends on that feature; i.e., how much the feature contributes to the concept's coherence. Complementarily, mutability reflects the aspects in which a concept is flexible. We show that features can be reliably ordered according to their mutability using tasks that require people to conceive of objects missing a feature, and that mutability (conceptual centrality) can be distinguished from category centrality and from diagnosticity and salience. We test a model of mutability based on asymmetric, unlabeled, pairwise dependency relations. With no free parameters, the model provides reasonable fits to data. Qualitative tests of the model show that mutability judgments are unaffected by the type of dependency relation and that dependency structure influences judgments of variability.
Endomyocardial biopsy technique for orthotopic heart transplantation and cardiac stem-cell harvesting.

Abstract Introduction Orthotopic heart transplantation (OHT) is performed using the bicaval and pulmonary venous anastomoses or the standard (biatrial) anastomoses. The special considerations of endomyocardial biopsy after OHT using the bicaval technique, and after myocardial infarction for harvesting of cardiac stem cells, have not been described. Methods When approached via the right or left internal jugular vein, important technical considerations were ultrasound guidance for vascular access; a soft, 80-cm, 0.035-inch, J-tipped guidewire; a long (23-cm), 7-Fr sheath; and a flexible 7-Fr, 50-cm bioptome. These technical aspects were helpful to avoid disruption of the superior vena cava suture line, avoid entry into the right atrial appendage or coronary sinus, avoid right ventricular free wall perforation, and provide ready access to the right ventricular septal wall. We used the same principles and technical considerations when obtaining the cardiac stem cells after myocardial infarction in patients enrolled in the CADUCEUS trial. Results From January 2002 to December 2005, 754 biopsy procedures were performed in 179 patients after OHT with the bicaval technique, using bioptome A. There was 1 occurrence of ventricular fibrillation requiring cardioversion, and no occurrence of cardiac tamponade during the procedure. From January 2006 to September 2013, 2818 biopsy procedures were performed in 1064 patients using bioptome B. No patient developed ventricular fibrillation or cardiac tamponade during the procedure. In 2010 and 2011, 23 biopsy procedures were performed in 23 patients after acute myocardial infarction, using bioptome B. No immediate complications occurred while performing these biopsies. The late occurrence of tricuspid regurgitation was not evaluated in this study. Conclusions Endomyocardial biopsy procedures can be safely performed after OHT with the bicaval technique and after myocardial infarction for harvesting of cardiac stem cells. Ultrasound guidance for vascular access, a long guidewire and sheath, and a flexible bioptome are important features for the safe conduct of the biopsy procedure.
Soil carbon storage and nitrogen and phosphorous availability in loblolly pine plantations over 4 to16 years of herbicide and fertilizer treatments

The impact of extended herbicide (H) and annual fertilizer (F) treatments on the mineral soil carbon (C) pool and nitrogen (N) and phosphorous (P) availability were analyzed in managed loblolly pine (Pinus taeda L.) plantations in the Piedmont of Georgia in stands ranging from 4 to 16 years old. Mineral soil C, N, P, and extractable P were measured in 66 plots in three locations comparing H, F, and their combination HF to the Control plots. Soils were sampled in January 2000 near Eatonton (n = 40), in August 2001 near Athens (n = 12), and in March 2003 near Dawsonville (n = 14). In addition, twelve plots (two H and two HF at each location) were measured on 17 dates using a mixed bead resin core technique to estimate mineral soil N availability. At all three study locations the H treatment tended to deplete the mineral soil C pool while, overall, the F treatments did not determine any significant mineral soil C increase. The soil C pool (0- to 50-cm depth) was depleted by about 5 Mg C ha−1 under the H-treated plots near Eatonton. The HF plots had much higher resin-extractable N than the corresponding H plots in all months of the year. At a plot level, HF values ranged from about 9 to 3,195 μg N g−1 resin while H values ranged from about 4 to 858 μg N g−1 resin. The corresponding annual cumulative resin-extractable N ranged from about 13 kg N ha−1 in the H to about 372 kg N ha−1 in the HF. Extractable P values were also elevated in all F-treated plots. Fertilization and herbicide treatments favored C sequestration only in the aboveground biomass. No significant change was observed in the mineral soil C pool, despite the generally observed increases in soil available N and P.
Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions.

The host immune response directed against Helicobacter pylori is ineffective in eliminating the organism and strains harboring the cag pathogenicity island augment disease risk. Because eosinophils are a prominent component of H. pylori–induced gastritis, we investigated microbial and host mechanisms through which H. pylori regulates eosinophil migration. Our results indicate that H. pylori increases production of the chemokines CCL2, CCL5, and granulocyte-macrophage colony-stimulating factor by gastric epithelial cells and that these molecules induce eosinophil migration. These events are mediated by the cag pathogenicity island and by mitogen-activated protein kinases, suggesting that eosinophil migration orchestrated by H. pylori is regulated by a virulence-related locus.
Papillary squamotransitional cell carcinoma of the vagina

A case of papillary squamotransitional carcinoma of the vagina is reported. The immunohistochemical profiles (cytokeratin-7 and -20) and the detection of human papillomavirus 16 support its close relationship to conventional squamous cell carcinoma. The lesion is compared to previously reported cases of papillary transitional cell carcinoma of the vagina and papillary squamotransitional cell carcinoma of the cervix.
Inhibition of Ref-1 stimulates the production of reactive oxygen species and induces differentiation in adult cardiac stem cells

Abstract Redox effector protein-1 (Ref-1) plays an essential role in DNA repair and redox regulation of several transcription factors. In the present study, we examined the role of Ref-1 in maintaining the redox status and survivability of adult cardiac stem cells challenged with a subtoxic level of H2O2 under inhibition of Ref-1 by RNA interference. Treatment of cardiac stem cells with a low concentration of H2O2 induced Ref-1–mediated survival signaling through phosphorylation of Akt. However, Ref-1 inhibition followed by H2O2 treatment extensively induced the level of intracellular reactive oxygen species (ROS) through activation of the components of NADPH oxidase, like p22phox, p47phox, and Nox4. Cardiac differentiation markers (Nkx2.5, MEF2C, and GATA4), and cell death by apoptosis were significantly elevated in Ref-1 siRNA followed by H2O2-treated stem cells. Further, inhibition of Ref-1 increased the level of p53 but decreased the phosphorylation of Akt, a molecule involved in survival signaling. T...
Structure and Evolution of Streptomyces Interaction Networks in Soil and In Silico

Soil grains harbor an astonishing diversity of Streptomyces strains producing diverse secondary metabolites. However, it is not understood how this genotypic and chemical diversity is ecologically maintained. While secondary metabolites are known to mediate signaling and warfare among strains, no systematic measurement of the resulting interaction networks has been available. We developed a high-throughput platform to measure all pairwise interactions among 64 Streptomyces strains isolated from several individual grains of soil. We acquired more than 10,000 time-lapse movies of colony development of each isolate on media containing compounds produced by each of the other isolates. We observed a rich set of such sender-receiver interactions, including inhibition and promotion of growth and aerial mycelium formation. The probability that two random isolates interact is balanced; it is neither close to zero nor one. The interactions are not random: the distribution of the number of interactions per sender is bimodal and there is enrichment for reciprocity—if strain A inhibits or promotes B, it is likely that B also inhibits or promotes A. Such reciprocity is further enriched in strains derived from the same soil grain, suggesting that it may be a property of coexisting communities. Interactions appear to evolve rapidly: isolates with identical 16S rRNA sequences can have very different interaction patterns. A simple eco-evolutionary model of bacteria interacting through antibiotic production shows how fast evolution of production and resistance can lead to the observed statistical properties of the network. In the model, communities are evolutionarily unstable—they are constantly being invaded by strains with new sets of interactions. This combination of experimental and theoretical observations suggests that diverse Streptomyces communities do not represent a stable ecological state but an intrinsically dynamic eco-evolutionary phenomenon.
Carbohydrate energy reserves and effects of food deprivation in male and female rainbow trout.

Abstract We investigated the effects of nutritional state on carbohydrate, lipid, and protein stores in the heart, liver, and white skeletal muscle of male and female rainbow trout. For fed animals we also partitioned glycogen into fractions based on acid solubility. Fish (10–14 months-old, ~ 400–500 g) were held at 14 °C and either fed (1% of body weight, every other day) or deprived of food for 14 days. Under fed conditions, glycogen was increased 54% in ventricles from males compared with females, and elevated in the liver (87%) and white muscle (70%) in sexually-maturing versus immature males. Acid soluble glycogen predominated over the acid insoluble fraction in all tissues and was similar between sexes. Food deprivation 1) selectively reduced glycogen and free glucose in male ventricles by ~ 30%, and 2) did not change glycogen in the liver or white muscle, or triglyceride, protein or water levels in any tissues for both sexes. These data highlight sex differences in teleost cardiac stores and the metabolism of carbohydrates, and contrast with mammals where cardiac glycogen increases during fasting and acid insoluble glycogen is a significant fraction. Increased glycogen in the hearts of male rainbow trout appears to pre-empt sex-specific cardiac growth while storage of acid soluble glycogen may reflect a novel strategy for efficient synthesis and mobilization of glycogen in fishes.
Local Dipole Field Contributions to Bond-Stretching Silicon-Hydrogen Vibrational Modes on Flat and Vicinal Si(111) Surfaces

Bond-stretching frequencies for bonded-H (and D) on flat and vicinal Si(111) surfaces have been calculated using a model that includes (i) short range valence forces and (ii) dynamic effects due to dipole–dipole interactions. Dipole–dipole interactions have been calculated exactly for flat surfaces, and for vicinal surfaces off-cut in the and directions terminated respectively by monohydride, Si–H, and dihydride, Si–H2, bonding at the step edges. Using short range force constants and effective charges obtained from isolated Si–H and Si–H2 stretching modes in hydrogenated amorphous Si, a-Si:H, as input parameters, the calculated coupled mode frequencies are in excellent agreement with experiment, i.e. using 5 empirical parameters, 16 frequencies in the range of 1500–2150 cm-1 are fit to better than 0.14%, or ±2–3 cm-1.
Photon emission from gold surfaces in air using scanning tunneling microscopy

Photon emission was observed at the tunnel junction of a scanning tunneling microscope while scanning Au structures in air. Emission levels of about 4000 counts per second (cps) were routinely achieved with Au tips, allowing photon maps to be produced. The similarity between these photon maps and the topographic images of the Au samples are discussed.
Pulmonary infection caused by Mycobacterium gordonae.

Summary Mycobacterium gordonae , a scotochromogenic organism, is considered a saprophyte. In sputum cultures the isolation of this organism or other species belonging to the scotochromogen group is not generally considered clinically significant since they are known to appear as commensals. We report the case of a 50-year-old man with pulmonary infection caused by M. gordonae . The clinical and radiographic findings in this case and the course are outlined. Diagnostic criteria of atypical mycobacterial infections are discussed and previously reported scotochromogenic infections briefly reviewed.
Photochemical Doping and Tuning of the Work Function and Dirac Point in Graphene Using Photoacid and Photobase Generators

This work demonstrates that photochemical doping of CVD-grown graphene can be easily achieved using photoacid (PAG) and photobase (PBG) generators such as triphenylsulfonium perfluoro-1-butanesufonate (TPS-Nf) and 2-nitrobenzyl N-cyclohexylcarbamate (NBC). The TPS-Nf ionic onium salt photoacid generator does not noticeably dope or alter the electrical properties of graphene when coated onto the graphene surface, but is very effective at inducing p-doping of graphene upon exposure of the PAG-coated graphene sample. Likewise, the neutral NBC photobase generator does not significantly affect the electrical properties of graphene when coated, but upon exposure to ultraviolet light produces a free amine, which induces n-doping of the graphene. Electrical measurements show that the doping concentration can be modulated by controlling the deep ultraviolet (DUV) light exposure dose delivered to the sample. The interaction between both dopants and graphene is also investigated. The photochemical doping process is able to tune the work function of the single-layer graphene samples used in this work from 3.4 eV to 5.3 eV. Finally, a p–n junction is fabricated and analyzed, showing that it is possible to control the position of the two current minima (two Dirac points) in the ambipolar p–n junction.
Synthesis of nanoparticles using high-pressure sputtering for magnetic domain imaging

Abstract We have developed a modified sputtering gun for direct synthesis of metallic nanoparticles, and used this system to produce magnetic domain images using high-resolution Bitter microscopy (HRBM). The nanoparticles are produced at 900 mTorr inside the gun and transported to the main vacuum chamber by the pressure difference between the chamber and the gun interior. Fe particles synthesized using the particle gun have been characterized using X-ray diffraction, atomic force microscopy, and transmission electron microscopy techniques. The particles are 15–30 nm in size with a pure BCC phase. Further, we have deposited these Fe nanoparticles on magnetic recording media and observed the domain patterns using optical microscopy, scanning electron microscopy, and atomic force microscopy. We achieve a spatial resolution of at most 80 nm.
Accurate critical constants for the one-sided approximate likelihood ratio test of a normal mean vector when the covariance matrix is estimated.

Summary. Tang, Gnecco, and Geller (1989, Biometrika76, 577–583) proposed an approximate likelihood ratio (ALR) test of the null hypothesis that a normal mean vector equals a null vector against the alternative that all of its components are nonnegative with at least one strictly positive. This test is useful for comparing a treatment group with a control group on multiple endpoints, and the data from the two groups are assumed to follow multivariate normal distributions with different mean vectors and a common covariance matrix (the homoscedastic case). Tang et al. derived the test statistic and its null distribution assuming a known covariance matrix. In practice, when the covariance matrix is estimated, the critical constants tabulated by Tang et al. result in a highly liberal test. To deal with this problem, we derive an accurate small-sample approximation to the null distribution of the ALR test statistic by using the moment matching method. The proposed approximation is then extended to the heteroscedastic case. The accuracy of both the approximations is verified by simulations. A real data example is given to illustrate the use of the approximations.
EFFECT OF SHORT-TERM COYOTE REMOVAL ON POPULATIONS OF COYOTE HELMINTHS

Coyote (Canis latrans) removal programs often are initiated despite the potential population regulatory mechanism of parasitism with increased coyote density. We investigated the effect of intensive, short-term coyote removal on population levels of helminths in juvenile and adult coyotes from western Texas. Coyotes were killed by aerial gunning every 3 mo for 2 yr on two 5,000 ha areas, which reduced the overall coyote density of these areas by about 50%. Two other 5,000 ha areas were used as comparison sites where a limited number of coyotes were killed each season. Densities on comparison sites remained stable throughout the study at a mean ± 1 SE of 0.14 ± 0.01 coyotes/km2. Twelve helminth species consisting of seven nematodes (Ancylostoma caninum, Physaloptera rara, Toxascaris leonina, Dirofilaria immitis, Spirocerca lupi, Oslerus osleri, and Capillaria aerophila), three cestodes (Taenia pisiformis, Taenia multiceps, and Mesocestoidessp.), one acanthocephalan (Oncicola canis), and one trematode (Alar...
Is Leasing a Substitute or Complement to Debt? Evidence From the Restaurant and Retail Industry

Prior empirical research has produced conflicting findings on the lease–debt relation. Although some studies provide evidence that leases substitute for debt, other studies have shown the lease–deb...
Internal Improvements Reconsidered

In a notable article published in 1955, Robert A. Lively analyzed the body of new writing on â€œthe role of government in the antebellum economy.â€ In it he coined the term, â€œThe American System,â€ to describe the characteristic pattern of â€œpublic support for business developmentâ€ or government â€œpartnership with enterprise.â€ The greater part of the literature covered dealt with the government promotion of canals and railroads, and he credited the writers with achieving â€œthe rescue of the internal improvements movement from the political historian.â€ Another bench mark is provided by the appearance in 1969 of the fourth edition of Edward C. Kirkland's History of American Economic Life. The revision devotes attention to the new trends that have appeared in the writing of economic history since the first edition in 1932, and Kirkland declares that the one that interested him the most was â€œthe increasing attention to the interrelationships between government and economic activity.â€ His chapter on â€œInternal Improvements and Domestic Commerceâ€ makes full use of the research on the role of governments in the promotion of canals and railroads but ends with the judgment that recent writers have tended to overstate the supposed social gains and to disregard the traditional but still valid concern with the financial losses. Meanwhile, Albert Fishlow, in his admirable book, American Railroads and the Transformation of the Ante-Bellum Economy, had challenged the writers on the American System on a number of issues, including the commonly accepted theory that railroads were built ahead of demand. His critique is summarized in the following statement: â€œthe recent useful destruction of the myth of ideological laissez faire must not give rise to the equally erroneous impression of all-embracing, and essential, public promotion.â€
Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach

Farnesyltransferase (FT) inhibitors can suppress tumor cell proliferation without substantially interfering with normal cell growth, thus holding promise for cancer treatment. A structure-based approach to the design of improved FT inhibitors relies on knowledge of the conformational flexibility of the zinc-containing active site of FT. Although several X-ray structures of FT have been reported, detailed information regarding the active site conformational flexibility of the enzyme is still not available. Molecular dynamics (MD) simulations of FT can offer the requisite information, but have not been applied due to a lack of effective methods for simulating the four-ligand coordination of zinc in proteins. Here, we report in detail the problems that occurred in the conventional MD simulations of the zinc-bound FT and a solution to these problems by employing a simple method that uses cationic dummy atoms to impose orientational requirement for zinc ligands. A successful 1.0 ns (1.0 fs time step) MD simulation of zinc-bound FT suggests that nine conserved residues (Asn127alpha, Gln162alpha, Asn165alpha, Gln195alpha, His248beta, Lys294beta, Leu295beta, Lys353beta, and Ser357beta) in the active site of mammalian FT are relatively mobile. Some of these residues might be involved in the ligand-induced active site conformational rearrangement upon binding and deserve attention in screening and design of improved FT inhibitors for cancer chemotherapy.
The use of messages in altering risky gambling behavior in college students: an experimental analogue study.

This study examined the effects of messages on altering risky gambling behavior in college students. While playing a chance-based computerized game with play money, three groups of participants either viewed occasional accurate messages that correctly described the contingencies of the game, neutral messages unrelated to the contingencies, or no messages. Participants in the accurate message condition spent overall less money gambling, played fewer trials in the final phase of the game when all trials resulted in losses, and were more likely to quit the game while they still had money remaining in the bank. The findings suggest that “reminders” about the random nature of games and the overall negative rate of return might lead to more responsible gaming.
Thirty Years of Weather Change and Effects on a Grassland in the Peloncillo Mountains, New Mexico

Thirty Years of Weather Change and Effects on a Grassland in the Peloncillo Mountains, New Mexico DOI:10.2458/azu_rangelands_v33i3_moir
Clinical efficacy and cost-effectiveness of rosuvastatin.

Rosuvastatin, which was approved by the FDA in 2003 and has been available in Europe since 2002, is the newest and most efficacious of the currently available 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins). More than 8 million patients have now been treated with rosuvastatin for up to 3 years, and initial concerns about the tolerability of this agent, prompted by the withdrawal of cerivastatin, have been answered. In fact, the lack of interactions of rosuvastatin with drugs metabolized by cytochrome P450 3A4 may provide a safety advantage not shared by other potent statins. Finally, rosuvastatin enables the majority of patients to achieve their cholesterol goals at initial doses, without the need for further dose titration and associated costs, and studies in both the USA and the UK have established its cost–effectiveness.
Human herpesvirus-8: Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma

Human herpesvirus 8 (HHV8) is a gamma herpesvirus associated with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma, lymphoproliferative diseases that are most commonly observed in immunocompromised individuals. The viral genome expresses genes responsible for inhibition of apoptosis, cell cycle entry, and angiogenesis. Viral homologs of human regulatory genes are expressed, providing stimuli for angiogenesis, B-cell proliferation, and immune evasion. Variations in expression of these factors give rise to the 3 known HHV8-associated malignancies. Identification of these pathogenetic mechanisms has led to exploration of targeted treatment approaches for all 3 of these disorders with success in Kaposi sarcoma and multicentric Castleman disease; primary effusion lymphoma remains a clinical challenge.
Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat

Sympathoexcitation and increased blood pressure evoked by central networks integrating defensive behavior are fundamental to the acute stress response. A balance between excitatory glutamatergic and inhibitory GABAergic neurotransmission in the dorsal periaqueductal gray (dPAG) results in a tonic level of activity in the alerting system. Neuromodulators such as endocannabinoids have been shown to influence the sympathoexcitatory and pressor components of acute stress in the dPAG, exemplified by the defense response as a model, but the mechanism of integration remains unknown. The present study examines the role of GABA and its interaction with endocannabinoids in modulating sympathetic nerve activity and blood pressure related to the defense response. Microinjection of the broad-spectrum excitatory amino acid dl-homocysteic acid (DLH) identified sites of the defense pathway in the dPAG from which an increase in renal sympathetic nerve activity and blood pressure could be evoked, and subsequent microinjections were made at the same site through a multibarrelled micropipette. Blockade of GABAA receptors or microinjection of the cannabinoid 1 receptor agonist anandamide elicited a renal sympathoexcitation and pressor response. Prior microinjection of the GABAA receptor antagonist gabazine attenuated the sympathoexcitation and pressor response associated with anandamide microinjection. In contrast, the sympathetic response to DLH was enhanced by GABAA receptor blockade. These data demonstrate that sympathoexcitatory neurons in the dPAG are under tonic inhibition by GABA and that endocannabinoids modulate this GABAergic neurotransmission to help regulate components of the defense response.
Teaching Evaluations: Perceptions Of Students And Faculty

This study conducts a survey of students and faculty at a business school on critical issues regarding student evaluations of teaching and identifies several significant differences between their perceptions. Students agreed more strongly than faculty that evaluations are higher in courses where the instructor teaches effectively and students learn more. Students also agreed more than faculty that they give higher evaluations for more challenging courses and for courses requiring an above-average amount of work. Unlike students, faculty agreed that students give higher evaluations in courses where they expect to earn a higher grade than they deserve.
Dietary Conjugated Linoleic Acid Lowers Plasma Cholesterol during Cholesterol Supplementation, but Accentuates the Atherogenic Lipid Profile during the Acute Phase Response in Hamsters

Conjugated linoleic acid (CLA) reportedly exerts anticarcinogenic and antiatherosclerotic effects in animals. To test the hypothesis that the putative antiatherosclerotic effect of CLA might derive from an anti-inflammatory or antioxidant action on lipoprotein metabolism, an acute phase response (APR) was elicited in hamsters while varying dietary cholesterol and vitamin E intakes in two experiments. The effect of CLA intake (to 1%) was examined with 0% (Experiment 1, 7 wk) and 0 or 0.3% (Experiment 2, 12 wk) cholesterol, at which point APR was induced. In hamsters not fed dietary cholesterol (Experiment 1), CLA exaggerated the rise in plasma and LDL cholesterol observed during the APR. When CLA was fed concurrently with cholesterol (Experiment 2), plasma and liver cholesterol were reduced up to 40% independent of the APR. In addition, CLA decreased body weight gain and adipose reserves in Experiment 1, but not in Experiment 2. Because CLA failed to attenuate APR and was not influenced by vitamin E status, an antioxidant/anti-inflammatory role was not apparent. However, the reduced burden on liver and lipoprotein cholesterol induced by CLA during cholesterol feeding, suggests that CLA curtailed cholesterol absorption, whereas the rise during APR suggests that CLA exaggerated the impaired clearance of plasma cholesterol associated with acute inflammation.
A decline in weight and attrition of muscle in colorectal cancer patients receiving chemotherapy with bevacizumab

Weight loss and muscle wasting are of critical importance to cancer patients because of their negative effects on survival, functional status, and tolerability of chemotherapy. Because previous data suggest vascular endothelial growth factor receptor inhibitors disrupt skeletal muscle pathways, such as PI3K and AKT, the current study explored weight loss and muscle wasting in colorectal cancer patients treated with bevacizumab. Patients were assessed for serial weight and radiographic changes in skeletal muscle at baseline and again within 3 months of starting cancer therapy. Computed tomography scans were used to assess muscle. Fifty-seven patients are the focus on this report. These patients manifested a decline in mean weight from 85 to 83 kilograms (P = 0.002). Mean skeletal muscle area at the L3 vertebral level dropped from 148 cm2 to 145 cm2 (P = 0.02). This drop in weight and skeletal muscle occurred independently of cancer progression. No statistically significant differences in survival were observed based on loss of weight or skeletal muscle. Colorectal cancer patients prescribed bevacizumab appear to lose weight and muscle over a few months even in the absence of cancer progression.
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase

We compared phenotypes of five strains of Mycobacterium tuberculosis (Mtb) differing in their expression of rv1248c and its product, 2-hydroxy-3-oxoadipate synthase (HOAS), with a focus on carbon source-dependent growth rates and attenuation in mice. Surprisingly, an rv1248c transposon mutant on a CDC1551 background grew differently than an rv1248c deletion mutant on the same background. Moreover, the same rv1248c deletion in two different yet genetically similar strain backgrounds (CDC1551 and H37Rv) gave different phenotypes, though each could be complemented. Whole genome re-sequencing did not provide an obvious explanation for these discrepancies. These observations offer a cautionary lesson about the strength of inference from complementation and sequence analysis, and commend consideration of more complex phenomena than usually contemplated in Mtb, such as epigenetic control.
Utility of sentinel lymphadenectomy in the management of patients with high-risk cutaneous squamous cell carcinoma.

BACKGROUND High-risk cutaneous squamous cell carcinoma (SCC) is an aggressive tumor with a significant rate of metastasis, especially nodal, and deaths yearly. Sentinel lymphadenectomy may be a valuable adjunct in the treatment of patients with cutaneous SCC at high risk for metastases with a clinical N0 status. OBJECTIVE To report the clinical and pathologic features in nine patients who underwent this procedure at a tertiary-care cancer center. METHODS Since 1995, a total of nine patients from the Cutaneous Oncology Program at the H. Lee Moffitt Cancer Center received preoperative lymphoscintigraphy and sentinel lymphadenectomy for high-risk cutaneous SCC with a clinical N0 status. RESULTS Histologically positive nodes were found in 4 of 9 cases (44%). Two of the four patients with positive sentinel nodes died of metastatic disease within 2 years. All five patients with negative sentinel nodes are alive and well at a median follow-up of 8 months (mean of 13 months). Preoperative lymphoscintigraphy and sentinel lymphadenectomy were well tolerated by all patients. CONCLUSION In this small series of predominantly trunk and extremity high-risk SCCs, sentinel lymph node biopsy was technically feasible with low morbidity. Sentinel lymphadenectomy may prove to have an important role in the management of high-risk cutaneous SCC with a clinical N0 status.
Discovery of Term Variation in Japanese Web Search Queries

In this paper we address the problem of identifying a broad range of term variations in Japanese web search queries, where these variations pose a particularly thorny problem due to the multiple character types employed in its writing system. Our method extends the techniques proposed for English spelling correction of web queries to handle a wider range of term variants including spelling mistakes, valid alternative spellings using multiple character types, transliterations and abbreviations. The core of our method is a statistical model built on the MART algorithm (Friedman, 2001). We show that both string and semantic similarity features contribute to identifying term variation in web search queries; specifically, the semantic similarity features used in our system are learned by mining user session and click-through logs, and are useful not only as model features but also in generating term variation candidates efficiently. The proposed method achieves 70% precision on the term variation identification task with the recall slightly higher than 60%, reducing the error rate of a naive baseline by 38%.
How inappropriate high‐pass filters can produce artifactual effects and incorrect conclusions in ERP studies of language and cognition

Although it is widely known that high-pass filters can reduce the amplitude of slow ERP components, these filters can also introduce artifactual peaks that lead to incorrect conclusions. To demonstrate this and provide evidence about optimal filter settings, we recorded ERPs in a typical language processing paradigm involving syntactic and semantic violations. Unfiltered results showed standard N400 and P600 effects in the semantic and syntactic violation conditions, respectively. However, high-pass filters with cutoffs at 0.3 Hz and above produced artifactual effects of opposite polarity before the true effect. That is, excessive high-pass filtering introduced a significant N400 effect preceding the P600 in the syntactic condition, and a significant P2 effect preceding the N400 in the semantic condition. Thus, inappropriate use of high-pass filters can lead to false conclusions about which components are influenced by a given manipulation. The present results also lead to practical recommendations for high-pass filter settings that maximize statistical power while minimizing filtering artifacts.
Closed-loop data-driven control of uncertain dynamic systems

A combined system-identification and control technique is proposed. The identified model is of the same order as that of the controller. The method works very well except when the measurements are corrupted by high amounts of noise. Some computer simulation results are presented, comparing the performance of the proposed technique with that of a neural networks-based controller.