cssi/SciSciGPT-SciSciNet huggingface dataset:
Velocity Profile Generation of a Robotic Manipulator to Minimize Tracking Error

The method described in this paper promotes accurate tracking of a given path by a robotic manipulator. The manipulator's velocity along the path is slowed as manipulator singularities or path corners are encountered. This adjustment is necessary to keep the manipulator tracking close to the path to satisfy error criteria. A numerical example is presented.
261 Colchicine Induced Myopathy in a Tacrolimus-Treated Renal Transplant Recipient

COLCHICINE INDUCED MYOPATHY IN A TACROLIMUSTREATED RENAL TRANSPLANT RECIPIENT Samitha Reddy, Zeenat Bhat, Mona Doshi and Elizebeth Wilpula. Detroit Medical Center, Detroit, Michigan. Colchicine induced myopathy is well described in literature. Several cases of colchicine toxicity have been reported in cyclosporine-treated patients due to a drug-drug interaction. However, to our knowledge, none have been reported in patients on tacrolimus. A 62-year-old African American male underwent a deceased donor renal transplant 4 years ago and had been doing well on tacrolimus-based immunosuppression. He presented to the clinic with an episode of gout and was started on colchicine 0.6 mg to be taken twice daily. After a few days, he was noted to have a four fold increase in AST (52 to 209 units/L) and an elevated CPK (9084 units/L). A stable therapeutic concentration of tacrolimus (6.1ng/mL), stable creatinine (1.2 mg/dL) and WBC were documented. His other medications were mycophenolate mofetil, omeprazole, allopurinol, losartan, atenolol, nifedepine, and vardenafil. He was not drinking grapefruit juice, or taking over-the-counter or herbal supplements. Colchicine toxicity was suspected and the drug was discontinued with prompt decrease of CPK to 5204 units/L in 3 days. Muscle and liver enzymes returned to normal in 2 months. Cyclosporine is a P-glycoprotein and CYP3A4/5 inhibitor causing increased colchicine absorption and decreased elimination. We hypothesize that tacrolimus, a weak inhibitor of P-gp and CYP3A4/5 increased the susceptibility of our patient to colchicine toxicity.
Has coarse ocean resolution biased simulations of transient climate sensitivity

We investigate the influence of ocean component resolution on simulation of climate sensitivity using variants of the GFDL CM2.5 climate model incorporating eddy-resolving (1/10°) and eddy-parameterizing (1°) ocean resolutions. Two parameterization configurations of the coarse-resolution model are used yielding a three-model suite with significant variation in the transient climate response (TCR). The variation of TCR in this suite and in an enhanced group of 10 GFDL models is found to be strongly associated with the control climate Atlantic meridional overturning circulation (AMOC) magnitude and its decline under forcing. We find that it is the AMOC behavior rather than resolution per se that accounts for most of the TCR differences. A smaller difference in TCR stems from the eddy-resolving model having more Southern Ocean surface warming than the coarse models.
Single-dose Levodopa Administration and Aging Independently Disrupt Time Production

We tested the hypothesis that age-related time production deficits are dopamine-mediated. The experiment was conducted double-blind, and with random assignment of 32 healthy aged and 32 healthy young participants to either inert placebo or levodopa (200 mg) groups. The procedure included training participants to produce two target time intervals (6 and 17 sec) in separate blocks, drug/placebo administration, a 1-hr delay, and then delayed free-recall time production retesting without feedback. Participants also performed a speeded choice reaction time (RT) task, as a control for potential dopaminergic and aging effects on attention and psychomotor speed. Results indicate that during retesting, aged participants show duration-dependent timing errors that are larger than those shown by the young participants. Levodopa administration yielded lengthened time production of both target intervals. The aging and levodopa effects did not interact. Also, aging slowed RT and increased RT variability, but levodopa had no effect on the RT. These results suggest that at this dosage and under these specific conditions, timing is dopamine-mediated but the effect of aging on time production is not. Moreover, the levodopa timing effect cannot be attributed to the effects of dopaminergic function on psychomotor speed.
Analysis of WWW traffic in Cambodia and Ghana

In this paper we present an analysis of HTTP traffic captured from Internet cafes and kiosks from two different developing countries -- Cambodia and Ghana. This paper has two main contributions. The first contribution is a analysis of the characteristics of the web trace, including the distribution and classification of the web objects requested by the users. We outline notable features of the data set which effect the performance of the web for users in developing regions. Using the trace data, we also perform several simulation analyses of cache performance, including both traditional caching and more novel off-line caching proposals. The second contribution is a set of suggestions on mechanisms to improve the user experience of the web in these regions. These mechanisms include both applications of well-known research techniques as well as offering some less well-studied suggestions based on intermittent connectivity.
Body images of 4-8-year-old girls at the outset of their first artistic gymnastics class.

Objective: The primary objective of this investigation was to compare body images of 54 girls (4-8 years old) who were beginning their first gymnastics class to 54 age-matched (� 1 year) and % body fat-matched (� 3%) girls not participating in gymnastics. Method: Rat- ings of actual and ideal body size and a computed measure of body dissatisfaction (actual minus ideal) were obtained. Body composition was measured with dual-energy x-ray absorptiometry. Results: Girls beginning gymnastics did not differ significantly from controls on (meanSD) actual (2.2 � 1.4 vs. 2.1 � 1.4), ideal (1.8 � 1.3 vs. 1.8 � 1.5), or body dissatisfaction (0.39 � 1.8 vs. 0.26 � 1.4) scores. Discussion: Body images of 4-8-year-old girls beginning their first artistic gymnastics class do not differ from non-gymnast controls matched on age and % body fat. This observation casts doubt on the idea that young girls who are dissatisfied with their body and want to be smaller are more likely to enroll in gymnastics classes than girls without this type of body dissatisfaction. # 2003 by Wiley Periodicals, Inc. Int J Eat Disord 34: 244-250, 2003.
Sex Differences in Cortical Thickness Mapped in 176 Healthy Individuals between 7 and 87 Years of Age

Findings from previous magnetic resonance imaging studies of sex differences in gray matter have been inconsistent, with some showing proportionally increased gray matter in women and some showing no differences between the sexes. Regional sex differences in gray matter thickness have not yet been mapped over the entire cortical surface in a large sample of subjects spanning the age range from early childhood to old age. We applied algorithms for cortical pattern matching and techniques for measuring cortical thickness to the structural magnetic resonance images of 176 healthy individuals between the ages of 7 and 87 years. We also mapped localized differences in brain size. Maps of sex differences in cortical thickness revealed thicker cortices in women in right inferior parietal and posterior temporal regions even without correcting for total brain volume. In these regions, the cortical mantle is up to 0.45 mm thicker, on average, in women than in men. Analysis of a subset of 18 female and 18 male subjects matched for age and brain volume confirmed the significance of thicker gray matter in temporal and parietal cortices in females, independent of brain size differences. Further analyses were conducted in the adult subjects where gender differences were evaluated using height as a covariate, and similar sex differences were observed even when body size differences between the sexes were controlled. Together, these results suggest that greater cortical thickness in posterior temporal inferior parietal regions in females relative to males are independent of differences in brain or body size. Age-by-sex interactions were not significant in the temporoparietal region, suggesting that sex differences in these regions are present from at least late childhood and then are maintained throughout life. Male brains were larger than female brains in all locations, though male enlargement was most prominent in the frontal and occipital poles, bilaterally. Given the large sample and the large range of ages studied, these results help to address controversies in the study of central nervous system sexual dimorphisms.
Thermal expansion studies of indium–iron oxide

Linear thermal expansion coefficients for the cubic bixbyite phase of bulk In 2―x Fe x O 3 have been determined using high resolution X-ray diffraction. The addition of Fe 2 O 3 to In 2 O 3 results in the formation of solid solutions in the body centered cubic phase with a decreasing lattice parameters as a funetion of increasing Fe content. The thermal expansion coefficients for solid solutions showed increased values in comparison to the values for pure In 2 O 3 phase.
Apparent elastic constants of cubic crystals and their pressure derivatives

Expressions for the pressure-dependent apparent elastic constants of cubic crystals are derived in terms of their original second- and third-order elastic constants. New expressions are obtained for the apparent compliances and their pressure derivatives. Results are shown to be in agreement with those based on the apparent elastic moduli.
Effects of Basic Rural Paratransit Characteristics on Organizational Culture

The purpose of this research is to determine if the basic characteristics of rural paratransit systems influence their organizational culture. "Organizational culture" is defined in this research as a pattern of shared basic assumptions for solving problems that is considered the correct way to perceive, think, and feel in relation to those problems. Eight categories of organizational culture specific to paratransit systems-including efficiency, customer focus, availability to the general public, dedication to human service agencies, growth, maintenance of the status quo, business, and charity-were explored. The survey was distributed to managers of paratransit agencies with similar funding sources and the same basic goal of providing community mobility. Respondents completed the survey by ranking the statements in each question in order of importance. Respondent rankings were analyzed with the use of basic characteristics of paratransit systems, including organization type, scheduling software, and syste...
Blueberry latent virus: An amalgam of the Partitiviridae and Totiviridae

A new, symptomless virus was identified in blueberry. The dsRNA genome of the virus, provisionally named Blueberry latent virus (BBLV), codes for two putative proteins, one without any similarities to virus proteins and an RNA-dependent RNA polymerase. More than 35 isolates of the virus from different cultivars and geographic regions were partially or completely sequenced. BBLV, found in more than 50% of the material tested, has high degree of homogeneity as isolates show more than 99% nucleotide identity between them. Phylogenetic analysis clearly shows a close relationship between BBLV and members of the Partitiviridae, although its genome organization is related more closely to members of the Totiviridae. Transmission studies from three separate crosses showed that the virus is transmitted very efficiently by seed. These properties suggest that BBLV belongs to a new family of plant viruses with unique genome organization for a plant virus but signature properties of cryptic viruses including symptomless infection and very efficient vertical transmission.
SANITARY CONDITIONS IN HAWAII.

GEORGE W. MCCOY.* Surgeon, United States Public Health Service, Honolulu, T. H. GENERAL CONSIDERATIONS. The Hawaiian Islands are very appropriately designated "The Cross Roads of the Pacific." The group consists of seven inhabitated islands lying almost directly in the line of travel from the western coast of North America to the Orient. Commercial relations and the exigencies of steamer traffic make Honolulu, the chief city of the archipelago, a port of call for vessels engaged in trade between the Far East and North and South America. Most of these vessels stop at Honolulu twice on each round trip. These considerations, while contributing to the commercial prosperity of the country, add to the complexity of its public health problems. In addition to the ordinary commerce with other countries the immigration problem is vastly more important here than elsewhere-. The labor supply in the Islands is totally inadequate to furnish all the help required by the various industries, chiefly sugar growing, and as a consequence it is necessary to import large numbers of foreigners. Formerly these people came almost exclusively from the Orient, but in recent years many have been brought from Europe, especially from Russia, Spain, and Portugal. Many of these men bring their families with them. A single steamer may bring a number of immigrants almost equal to 1 per cent. of the total population of the Islands. RELATION TO GENERAL GOVERNMENT. The Island of Oahu, on which the city of Honolulu is situated, is one of the most important military and naval bases in the possession of the United States. In the neighborhood of five thousand United States Troops are stationed here at the present time and it is quite likely that within the next few years the number will be largely increased. It is obvious therefore that the Federal Government will always have a very great interest in the sanitary conditions of the Islands. This is recognized by the Territorial Government as well as by those charged with the responsibility of caring for the public health interests of the Federal Government. At the request of the Territorial authorities an officer of the United States Public Health Service was detailed for duty as sanitary adviser to the Governor of Hawaii. It must not be inferred from this assignment that the Territorial health authorities are not efficient and energetic. The very reverse is true. The writer is not acquainted with any state having a more effective health department than that of Hawaii. It was felt, however, that on account of the importance to the United States of the sanitary conditions in the Islands it would be well to have the assistance of an officer detailed by the Federal Government. This is particularly appropriate inasmuch as Hawaii being a Territory and not a sovereign state is, in a sense, a ward of
Line-up: a complete and automatic linearizability checker

Modular development of concurrent applications requires thread-safe components that behave correctly when called concurrently by multiple client threads. This paper focuses on linearizability, a specific formalization of thread safety, where all operations of a concurrent component appear to take effect instantaneously at some point between their call and return. The key insight of this paper is that if a component is intended to be deterministic, then it is possible to build an automatic linearizability checker by systematically enumerating the sequential behaviors of the component and then checking if each its concurrent behavior is equivalent to some sequential behavior.We develop this insight into a tool called Line-Up, the first complete and automatic checker for deterministic linearizability. It is complete, because any reported violation proves that the implementation is not linearizable with respect to any sequential deterministic specification. It is automatic, requiring no manual abstraction, no manual specification of semantics or commit points, no manually written test suites, no access to source code.We evaluate Line-Up by analyzing 13 classes with a total of 90 methods in two versions of the .NET Framework 4.0. The violations of deterministic linearizability reported by Line-Up exposed seven errors in the implementation that were fixed by the development team.
A theoretical framework for defining similarity measures for boolean search request formulations, including some experimental results

Abstract Clusters of queries submitted to a given information retrieval system can be used as a basis for an effective method of clustering documents. This indirect procedure of document clustering requires the availability of a similarity measure for queries. Research carried out along these lines has resulted in the development of some methodologies for estimating such query similarities, applicable both in the case of queries characterized by sets of weighted or unweighted index terms and in the case of queries represented by Boolean combinations of index terms. This paper reports the results of further research by the author into a methodology of the latter type, i.e. a methodology for determining the similarity between queries characterized by Boolean search request formulations. The novelty of the presented approach, as compared with the methodology introduced in an earlier paper by the author, is that some relations among index terms are now taken into account. A number of similarity measures for Boolean combinations of index terms are discussed here in some detail. The rationale behind these measures is outlined, and the conditions to be met for ensuring their equivalence are identified. Moreover, the results of an experiment concerning two of the similarity measures introduced are given.
Anti-windup compensation for nonlinear systems via gradient projection: Application to adaptive control

Control saturation is an important limitation in practical control systems and it is well known that performance degradation or instability may result if this limitation is not effectively addressed. Using ideas from the gradient projection method in nonlinear programming, we propose a new anti-windup scheme for multi-input, multi-output nonlinear dynamic controllers. The key idea is to project the controller state update law onto the tangent plane of the active saturation constraints. To do this, we first extend the gradient projection method to the continuous-time case that can accommodate multiple nonlinear constraints. This is then used for anti-windup compensation, resulting in a hybrid controller that switches its state update law over arbitrary combinations of saturating controls. Simulations on a nonlinear two-link robot driven by an adaptive sliding mode controller illustrates its effectiveness and limitations.
Validation of 24-Hour Flucytosine MIC Determination by Comparison with 48-Hour Determination by the Clinical and Laboratory Standards Institute M27-A3 Broth Microdilution Reference Method

Flucytosine and itraconazole are the only antifungal agents for which the Clinical Laboratory and Standards Institute recommendations include MIC breakpoint readings at 48 h only. Here we show good essential and categorical agreement between the flucytosine MIC readings at 48 and 24 h for Candida species.
Agricultural Man-power

During the past year, agricultural man-power in Canada has assumed a new importance. With a growing recognition that food is a vital weapon of war and the realization that the farm working force has been seriously depleted during the past three and a half years, the problems of farm labour have been forced into the foreground. It was natural perhaps, during the first years of war, when munitions, aeroplanes, army vehicles, and ships were in such great demand; when men were needed in large numbers for the armed forces; and when surpluses of many essential farm products existed, that farm production should be considered of secondary importance. Today, the situation has changed. The relative importance of food has sharply increased. Not only have the surpluses of bacon, dairy, and poultry products disappeared, but the requirements of the Allied Nations for these and other provisions have greatly expanded. To contribute her share in supplying essential foods and fibres to the Allied Nations and to meet home requirements, Canada must have adequate farm man-power. It is proposed in this paper to deal with the subject of agricutural man-power largely from an economic point of view. In making this limitation, it is realized that the economic considerations cannot be divorced arbitrarily from other ever-present social factors. These latter factors cannot be ignored, and will have to be considered, at least indirectly, in several parts of the discussion. The main economic aspects of agricultural man-power covered here might be briefly indicated. In the first place, the nature of the present farm man-power problem will be outlined. The extent and character of the existing farm working force will be analysed and the sources of additional labour discussed. The mobilization of this man-power through measures introduced by the federal and provincial governments will be reviewed. Finally, some problems for the immediate and long-run future will be raised and discussed.
Food safety education for people with diabetes and pregnant women: A positive deviance approach

Abstract Few education programs target audiences at high-risk for foodborne illness, especially people with diabetes and pregnant women. The objective of this study is to develop a food safety education program for each using a positive deviance approach. The positive deviance focus group is a novel educational intervention that allows participants to discuss their food handling behaviors and decide to try recommended positive practices modeled by people like themselves. To fit within the educational programs offered by the collaborating institutions, three sessions were given, discussing safe handling topics: ‘Cook and Chill,’ ‘Clean and Separate,’ and ‘Choose Safe Food.’ People with diabetes (32) and pregnant women (29) participated in the study. Focus groups were audiotaped and transcribed. Participants became involved and inspired by vivid discussions and were inspired to change their behaviors to the recommended food handling practices modeled by their peers. Safe food handling practices were reinforced by take-home tasks focused on using refrigerator and cooking thermometers and using separate cutting boards. Participants were unaware of details associated with safe handling recommendations, such as the recommended temperature for cooking specific items or the temperature of the refrigerator. Results of this study indicate that positive deviance discussion module could be a promising alternative to traditional methods of food safety education.
Advantages of Using Fluorescent Light with Dissecting Microscopes in Taxonomic Investigations

Entomologists have traditionally used incandescent light with dissecting microscopes in their taxonomic and biological studies. Incandescent light produces excessive glare and shadow. Glare can distort images of large structures and may completely mask minute details. It contributes to eye fatigue and reduces efficiency. Shadowing prevents clear inspection of the entire fields of view, which means that frequent repositioning of specimens is necessary. These disadvantages of incandescent illumination are significantly reduced or eliminated by using fluorescent lighting
The impact of public and semi-public information on cotton futures market

ABSTRACTThis study estimated the impact of all major public and semi-public reports on the cotton futures market from 1995 through 2012. The estimation was based on the event study approach with the events measured by the release of five major reports: Export Sales, Crop Progress, World Agricultural Supply and Demand Estimates (WASDE) and Prospective Plantings (public reports from US Department of Agriculture) and Cotton This Month (semi-public report from International Cotton Advisory Committee). The best-fitting IGARCH(1,1)-t model that accounted for the day-of-week, seasonality and stock levels was used to measure the report effects on daily nearby cotton close-to-close futures returns. Prospective Plantings and WASDE reports appeared to be the most important sources of information in the cotton markets moving the conditional standard deviation of returns by an average of 14.4 and 9.6 percentage points, respectively. However, significant market reaction was not found for the other three reports. Our an...
Philadelphia's Lords of the Docks: Interracial Unionism Wobbly-Style

In the early twentieth century, several thousand Philadelphia longshoremen organized themselves into a powerful, durable, and effective labor union. These men, who proudly belonged to the Industrial Workers of the World, proved willing and able to employ the Wobblies’ direct action tactics to improve their lives. Perhaps even more impressive is that Local 8 was one of the most, perhaps the most, racially inclusive union of its era. Few institutions of any sort at that time in America could claim to be more committed to interracial, multiethnic unionism than Local 8. For ideological and pragmatic reasons, Local 8 stood for racial and ethnic integration on the waterfront. Uniting a diverse workforce was essential to the union's success. Indeed, the union collapsed when Local 8 was split along racial lines. This article looks at the rise and fall of the Progressive Era's most integrated union.
The effect of speed limits on drivers' choice of speed: A random parameters seemingly unrelated equations approach

Drivers’ choice of speed has long been known to be a critical factor in both the likelihood and severity of vehicle crashes. Given this, understanding drivers’ choice of speed and the possible effect that posted speed limits may have on this choice, is a critical element of safety research. This paper seeks to provide new insights on drivers’ speed-choice process by studying U.S. interstate highways (all of which are constructed to the same design-speed standard) under three distinct speed limits (55 mi/h, 65 mi/h and 70 mi/h). Using a survey of interstate drivers that asked respondents their normal operating speed on interstates posted with these speed limits (under light traffic conditions), a random parameters seemingly unrelated regression estimation approach is used to account for both the interrelation among the choices under the three speed limits and for the unobserved heterogeneity across respondents. The estimation results show that a wide variety of factors influence the choice of speed in the presence of speed limits, including driver age, gender, marital status, number of children, driver education level, household income, age when the driver was first licensed, and opinions about pavement quality. The findings in this paper have important implications relating to the factors that may affect speed-limit compliance, and also demonstrate the methodological potential of the random parameters seemingly unrelated regression estimation approach to address a number of safety-related problems involving a series of inter-related continuous dependent variables.
Bromocriptine Inhibits Growth Hormone Release from Rat Pituitary Cells in Primary Culture

AbstractThe action of the potent dopamine receptor agonist bromocriptine was studied in primary cultures of rat anterior pituitary cells. Bromocriptine inhibited both prolactin and growth hormone release in a concentration-dependent manner. This effect was blocked by the dopamine receptor antagonist spiperone when the agonist and antagonist were added coincidently. In contrast, spiperone was unable to affect the actions of bromocriptine if added 1 min after bromocriptine application or later. These results suggest that dopamine receptors exist not only on mammotrophs, but also on somatotrophs in vitro.
Natural Rights and the Right to Choose: The Drift from Natural Rights

Blackstone, that venerable commentator on the English law, insisted that it was a chimera or an oxymoron to suggest that the law may contain a principle of revolution. Laws were settled rules; revolutions involved the overturning of the deepest rules, the unsettling of that which had been most deeply settled. And yet, what Sir William Blackstone regarded as a contradiction in terms, James Wilson regarded not only as plausible, but as an understanding that ran to the foundation of the law in America. In his first lecture on jurisprudence, in 1790, Wilson insisted that “a revolution principle certainly is, and certainly should be taught as a principle for the constitution of the United States, and of every State in the Union.” As paradoxical as that may sound, Wilson recognized that it was simply an implication that flowed from the understanding of natural rights or natural justice. For natural right implied an understanding of what was just or right apart from the positive law, the law that was “posited,” enacted, set forth in official statutes and decrees. Built into the logic of natural rights, one might say, was a recognition that the positive law, a “law” established in a thoroughly legal manner, may nevertheless be wanting in the substance of justice or lawfulness. For that reason, a statute might not be “lawful” in the strictest sense even if it were passed with a thorough respect for the forms of law.
Cramps, Muscle Stiffness, and Exercise Intolerance

A cramp is an involuntary painful contraction of a muscle or part of a muscle. Cramps can occur in normal children during and after vigorous exercise and after excessive loss of fluid or electrolytes. The characteristic electromyogram (EMG) finding for such cramps is the repetitive firing of normal motor unit potentials. Stretching the muscle relieves the cramp. Partially denervated muscle is particularly susceptible to cramping not only during exercise, but also during sleep. Night cramps may awaken patients with neuronopathies, neuropathies, or root compression. Cramps during exercise occur also in patients with several different disorders of muscle energy metabolism. The EMG characteristic of these cramps is electrical silence.
Training and Abrichtung: Wittgenstein as a tragic philosopher of education

AbstractAs a landmark philosopher of language and of mind, Ludwig Wittgenstein is also remarkable for having crossed, with apparent ease, the ‘continental divide’ in philosophy. It is consequently not surprising that Wittgenstein’s work, particularly in the Philosophical Investigations, has been taken up by philosophers of education in English. Michael A. Peters, Christopher Winch, Paul Smeyers and Nicholas Burbules, and others have engaged extensively with the implications of the later Wittgenstein’s philosophy for education. One challenge they face is Wittgenstein’s use of the word ‘training.’ It appears throughout his discussions of language learning and in his periodic references to education. This is made all the more problematic by realizing that the German term Wittgenstein uses consistently is Abrichtung, which refers to animal dressage or obedience training, which is currently used in sadomasochistic practice, and which also connotes also the breaking of an animal’s will. I argue that this little...
Promoting Strategic Research on Inclusive Access to Rich Online Content and Services

How can the broader field of computer science research be harnessed to address challenges and opportunities in accessibility? This poster summarizes the findings of a workshop, sponsored by the Computing Community Consortium (USA), that brought together computer scientists, representatives of disability advocacy organizations, people from industry, and government employees to develop an agenda for strategic research. Members of the ASSETS community may find the reports useful in organizing collaborative projects with others in the computer science community.
PEG3 binds to H19-ICR as a transcriptional repressor.

ABSTRACTPaternally expressed gene 3 (Peg3) encodes a DNA-binding protein with 12 C2H2 zinc finger motifs. In the current study, we performed ChIP-seq using mouse embryonic fibroblast (MEF) cells. This experiment identified a set of 16 PEG3 genomic targets, the majority of which overlapped with the promoter regions of genes with oocyte expression. These potential downstream genes were upregulated in MEF cells lacking PEG3 protein, suggesting a potential repressor role for PEG3. Our study also identified the imprinting control region (ICR) of H19 as a genomic target. According to the results, PEG3 binds to a specific sequence motif located between the 3rd and 4th CTCF binding sites of the H19-ICR. PEG3 also binds to the active maternal allele of the H19-ICR. The expression levels of H19 were upregulated in MEF cells lacking PEG3, and this upregulation was mainly derived from the maternal allele. This suggests that PEG3 may function as a transcriptional repressor for the maternal allele of H19. Overall, the ...
Does the Strength of the Victim-Offender Overlap Depend on the Relationship Between the Victim and Perpetrator?

Abstract Purpose Strong evidence of the correlation between victimization and offending has led researchers to investigate both the causal relationship between victimization and offending and possible contingencies in this relationship. But, research has yet to investigate whether the victim's relation to the perpetrator impacts the strength of the victim-offender overlap. Drawing on betrayal trauma theory, we examine whether the victim-offender overlap depends on the relationship between the victim and the perpetrator. Methods Using data from the Project on Human Development in Chicago Neighborhoods, a three-level logistic item response model nested 7936 violent crime item responses at level 1 within 992 subjects (at level 2) representing 174 neighborhoods across metropolitan Chicago (at level 3). Results Victimization by a relatively unfamiliar (acquaintance) or unknown (stranger) perpetrator did not increase the likelihood of subsequent violent behavior, while victimization by a family member, peer, or gang member was significantly associated with future violence. Among known perpetrators, victimization by a family member was least likely to generate an offending response. Conclusions Victimization and offending are inextricably linked, but the ways in which these constructs are related are nuanced. In particular, the strength of the victim-offender overlap depends on the relationship between the victim and perpetrator.
A trial of benorylate tablets in the symptomatic relief of osteoarthritis.

The effectiveness of Benoral Tablets in controlling joint pain and stiffness in osteoarthritis was assessed over a two-week period in a multicentre general practice open study.In this trial it has been demonstrated that a correlation exists between pain relief and relief from stiffness for patients suffering from osteoarthritis taking Benoral Tablets over this period. It way also found that patients with initially mild to moderate pain benefited most from their treatment.
Total electron scattering cross sections of molecules containing H, C, N, O and F in the energy range 0.2–6.0 keV

Abstract Based on the effective atomic total electron scattering cross sections (EATCS) of atoms in a molecular environment, a simple model is proposed to predict the total electron scattering cross sections (TCS) of H, C, N, O, and F containing molecules. The EATCS for these five atoms are reported for 0.2–6.0 keV energies. The predicted TCS by this model are compared with experimental TCS in the literature. The experimental TCS of CHF 3 , C 2 F 4 , C 2 F 2 H 2 , C 4 F 6 , and c-C 4 F 8 have been obtained for 0.2–4.5 keV electrons by measuring the attenuation of the electron beam through a gas cell.
In the Shadow of Nikolai Danilevskii: Universalism, Particularism, and Russian Geopolitical Theory

AbstractIn order to contribute to our understanding of Russian geopolitical theory, this article investigates closely the figure of Nikolai Danilevskii. The article pays special attention to the thinker’s increased influence on contemporary Russian geopolitical thought, by presenting qualitative and quantitative evidence of this influence. It explains Danilevskii’s rise by looking at Western pressures on Russia and the country’s internal vulnerabilities. Such vulnerabilities emerged from the breakup of the Tsarist and the Soviet state, respectively, by providing the required context for the emergence of defensive nationalist ideas.
Electrochemical studies of Pd-doped Cu and Pd-doped Cu-Al intermetallics for understanding corrosion behavior in wire-bonding packages

Abstract This study investigated the electrochemical characterizations in the field of wire metallurgy (Pd concentration) and molding compound chemistry (chloride concentration) to find ways to reduce metallic entities' susceptibility to corrosion at ball-pad interfaces. The open circuit potentials and potentiodynamic polarization curves of various metallic entities found in a Cu(Pd)-Al bonding interface were obtained in near-neutral electrolytes of 100 ppm, 20 ppm, and 1 ppm of NaCl in high-purity water. From X-ray diffraction spectra, it was found that Pd could be homogeneously incorporated into Cu 9 Al 4 , the Cu-rich intermetallic compound (IMC) also referred to as γ but not into CuAl 2 , the Al-rich IMC also referred to as θ for arc-melted specimens. For Cu-Pd alloys, at a given chloride concentration, increasing Pd concentration causes the value of open-circuit potential (E oc ) to increase and corrosion current density (i corr ) to decrease. Likewise, for a given amount of Pd in Cu-Pd alloy, decrease in the NaCl concentration causes the value of E oc to increase and i corr to decrease. Interestingly, for high concentration of Pd as in the case of Cu-9Pd, E oc and i corr became less sensitive to the NaCl concentrations investigated. This can be attributed to the Pd enrichment on the corroding surface that reduces the anodic dissolution rate of Cu. For Pd-doped γ intermetallics, increasing Pd concentration causes a systemic increase in the value of E oc , but at a lower concentration of Pd, the value of i corr was increased. The addition of Pd to γ causes an increase in the cathodic current density due to the high cathodic activity of Pd, while the passivation of Al in γ reduces the extent of the anodic current density reduction due to the addition of Pd, which leads to a higher value of i corr at a low Pd concentration. This is true even when the NaCl concentration is as low as 1 ppm. On the other hand, the influence of NaCl concentration on the E oc and i corr of γ IMC was always observed, even with Pd addition.
Mastering a Bacterial Photosynthetic System

As part of a project dedicated to modeling how single-celled purple bacteria turn light into food, a team of computational scientists from the University of Illinois at Urbana-Champaign simulated a complete ATP synthase, the power plant of the cell, in all-atom detail. The work builds on the project’s first phase—a 100-million atom photosynthetic organelle called a chromatophore—and gives scientists an unprecedented glimpse into a biological machine whose energy efficiency far surpasses that of any artificial system.
Mapping the undiscovered country: a brief introduction to contemporary afterlife fiction for young adults

In the last fifteen years, fiction set in or about the afterlife has become a popular and critically acclaimed sub-genre within contemporary speculative fiction for young adults especially, but not only, in English-language publishing. These narratives, where the main characters die at the beginning of the story and find themselves in an alien world, the world beyond death, have developed into a fertile ground for imaginative and intellectual challenge and discovery, as a means both to depict the ultimate culture shock and a challenging exploration of otherness and alienation.
The acceptability and feasibility of emailed parent questionnaires for medical and developmental surveillance after NICU discharge.

The following are the objectives of this study: (1) Assess the feasibility and acceptability of emailing parent-reported measures of infant health and development after NICU discharge. (2) Examine whether post-discharge questionnaire data helps identify infants most likely to benefit from specialized follow-up care. Parents of 51 infants <32 weeks’ gestation received email questionnaires at 44 weeks postmenstrual age (PMA) and 6 months corrected age (CA). Adverse infant outcomes were assessed in-person at 6 months: (1) Bayley-III cognitive or motor score <85; (2) weight, length, or head circumference <10th percentile; (3) new referral for medical or developmental services. Questionnaire response was 48 (94%) at 44 weeks PMA and 46 (90%) at 6 months CA. 36 (70%) infants were assessed at 6 months; 72% had at least 1 adverse outcome. Poorer transition home, feeding problems, and special health care needs at 44 weeks PMA predicted adverse outcomes. Feeding problems, maternal depression, and lower infant health-related quality of life at 6 months CA correlated with adverse outcomes. Emailed questionnaires after NICU discharge were feasible to implement and acceptable to families. Repeated post-discharge assessments may help identify infants at heightened health and developmental risk.
Polymer effects on PAG acid yield in EUV resists

The photo-mechanism of EUV exposures in chemically amplified photoresists are much different than that of previous lithographic wavelengths. Electrons generated during EUV exposure are demonstrated to be a source of acid production through a process referred to as electron trapping. Density functional theory modeling indicates that it is energetically favorable for the PAG molecule to decompose if an electron is trapped. Low-energy electrons unlikely to produce holes and secondary electrons generate acid indicating electron-PAG interactions are capable to induce decomposition. Additionally, a more easily reduced PAG (i.e. higher likelihood of trapping an electron) produces a higher acid yield supporting electron trapping as a process of acid production. An acid indicator, Coumarin 6, was used to determine the number of acids generated per absorbed EUV photon. The results of these measurements indicate that electron-PAG interactions are a source of acid production through electron trapping; thus, increasing the number of electron-hole pairs available to induce chemical reactions would improve sensitivity. It is expected that lower band gap materials produce more electron-hole pairs after an absorption event. Subsequently, these measurements show that lower band gap polymers generate higher acid yields.
Personalized Medication Adherence Motivating and Reminding System (PMAMRS)

Medication non adherence reduces quality of care, causes unnecessary cost and negatively affects the quality of life of the patients. Using community engagement approach and adopting design science research guidelines, this research develops a prototype to motivate and improve patient prescription adherence.
Semantic Role Labeling for Open Information Extraction

Open Information Extraction is a recent paradigm for machine reading from arbitrary text. In contrast to existing techniques, which have used only shallow syntactic features, we investigate the use of semantic features (semantic roles) for the task of Open IE. We compare TextRunner (Banko et al., 2007), a state of the art open extractor, with our novel extractor SRL-IE, which is based on UIUC's SRL system (Punyakanok et al., 2008). We find that SRL-IE is robust to noisy heterogeneous Web data and outperforms TextRunner on extraction quality. On the other hand, TextRunner performs over 2 orders of magnitude faster and achieves good precision in high locality and high redundancy extractions. These observations enable the construction of hybrid extractors that output higher quality results than TextRunner and similar quality as SRL-IE in much less time.
When Markets Are Grue

The article of record as published may be located at http://dx.doi.org/10.2139/ssrn.571922
New Insights into the Phenotype and Cell Derivation of B Cell Chronic Lymphocytic Leukemia

For many decades, B cell chronic lymphocytic leukemia (B-CLL) stood out as a B cell-derived malignancy that was difficult to position within the framework of the available B cell differentiation scheme: First, the histology as well as the immunophenotype did not quite resemble that of any normal lymphocyte; second, in contrast to almost all other B cell tumor subtypes, the immunoglobulin variable region (IgV) genes of B-CLL cases could be either unmutated or somatically mutated; third, the genomic lesions observed in B-CLL were markedly distinct from those of the other major B cell malignancies, which typically exhibit balanced chromosome translocations. Recent advances in the characterization of both B-CLL and normal B cell subpopulations by phenotypic analysis, global gene expression profiling, as well as extensive IgV gene repertoire analyses have shed new light on the phenotype and the cell derivation of B-CLL and provided novel hypotheses concerning its pathogenesis. Here we summarize recent work relevant to these issues and conclude that B-CLL may be derived from a cell that can be referred to as a marginal zone B cell. Moreover, we propose that the lack of chromosomal translocations in B-CLL may be related to their derivation from marginal zone B cells, since somatic hypermutation and Ig class switch, the processes that generate chromosome translocations in most germinal center (GC)-derived malignancies, are no longer active in marginal zone B cells. Also, we discuss similarities and differences between B-CLL and hairy cell leukemia (HCL) and suggest that also HCL may be derived from a post-GC memory or marginal zone B cell.
PTSD in civilian populations after hospitalization following traumatic injury: A comprehensive review.

Abstract Background Injuries and their comorbidities affect victims far beyond their physical recovery period. Some study-measures show that more than half of patients hospitalized for a traumatic injury suffer from Acute Stress Disorder, alcohol dependence, and recurrent trauma. Overall, this literature review serves to review risk factors for PTSD, screening tools, follow-up strategies, and gaps in the literature for achieving feasible patient-centered interventions for the prevention of PTSD after a traumatic injury. Data sources A literature review was performed from August 1, 2017 to March 19, 2018, from 3 Databases: PubMed, CINAHL and Cochrane, with keywords: “PTSD”, “Post-traumatic Stress Disorder”, “Civilians”, “Traumatic”, “Injury”, “Follow-up”, “Treatment”, “Referral”, “surgery”, “surgical”, “Intervention”, and “Insured”, “underinsured”. Conclusions Reported risk factors for PTSD were: prior psychiatric disorder, gunshots, and lack of social support. Most articles use the Posttraumatic Stress Disorder Checklist – Civilian version. Follow-up strategies mainly focus on multidisciplinary intervention protocols, including social workers, behavioral health specialists, and psychiatrists. Finally, gaps in the literature show the need for bilingual/bicultural patient-centered care for elderly, diverse ethnic backgrounds, and insured vs. uninsured patients.