cssi/SciSciGPT-SciSciNet huggingface dataset:
Two-Photon X-Ray Diffraction.

The interference pattern of a circular photon source has long been used to define the optical diffraction limit. Here we show the breakdown of conventional x-ray diffraction theory for the fundamental case of a “source”, consisting of a back-illuminated thin film in a circular aperture. When the conventional spontaneous x-ray scattering by atoms in the film is replaced at high incident intensity by stimulated resonant scattering, the film becomes the source of cloned photon twins and the diffraction pattern becomes self-focused beyond the diffraction limit. Furthermore, the case of cloned photon pairs is compared to and distinguished from entangled photon pairs or biphotons.
An examination of the etiologic overlap between the genetic and environmental influences on insomnia and common psychopathology.

Background Insomnia is comorbid with internalizing and externalizing psychiatric disorders. However, the extent to which the etiologic influences on insomnia and common psychopathology overlap is unclear. There are limited genetically informed studies of insomnia and internalizing disorders and few studies of overlap exist with externalizing disorders. Methods We utilized twin data from the Virginia Adult Twin Studies of Psychiatric and Substance Use Disorders (total n = 7,500). Insomnia, internalizing disorders (major depressive disorder [MDD], generalized anxiety disorder [GAD]), and alcohol abuse or dependence (AAD) were assessed at two time points, while antisocial personality disorder (ASPD) was assessed once. Cholesky decompositions were performed in OpenMx and longitudinal measurement models were run on available phenotypes to reduce measurement error. Results The latent additive genetic influences on insomnia overlapped significantly (56% for females, 74% for males) with MDD and were shared completely (100%) with GAD. There was significant overlap of latent unique environmental influences, with overlap ranging from 38 to 100% across disorders. In contrast, there was less genetic overlap between insomnia and externalizing disorders, with 18% of insomnia's heritability shared with AAD and 23% with ASPD. Latent unique environmental overlap between insomnia and both externalizing disorders was negligible. Conclusions The evidence for substantial genetic overlap between insomnia and stable aspects of both internalizing disorders suggests that there may be few insomnia-specific genes and investigation into unique environmental factors is important for understanding insomnia development. The modest overlap between insomnia and externalizing disorders indicates that these disorders are genetically related, but largely etiologically distinct.
A hierarchical Bayesian approach to estimate endosymbiont infection rates

Endosymbionts may play an important role in the evolution of the Insecta. Bacteria such as Wolbachia, Cardinium, and Rickettsia are known to manipulate their host` reproduction to facilitate their own. Indeed, there are many well know cases where Wolbachia (Alphaproteobacteria: Rickettsiaceae) induces one of four manipulative phenotypes (cytoplasmic incompatibility, male killing, feminization, and parthenogenesis). The scale of infection among species has been a major subject of investigation, but this is not an easy endeavor and different approaches have yielded different estimates. One aspect of this problem that may be underappreciated arises when multiple yet independent samples are taken within a taxon. When independent samples within a taxon are treated as levels of a hierarchy the problem is greatly simplified because error propagates through the model in a realistic and intuitive manner. Here, we present a hierarchical Bayesian approach to estimate infection frequency where multiple independent samples were collected across multiple taxonomic levels. We apply this model to estimate the rates of infection for Wolbachia in the Lepidoptera, and apply the model with a correction to account for phylogenetic non-independence. In addition, we highlight the present body of knowledge regarding Wolbachia and its effects with regards to the Lepidoptera. Our model estimates suggests that the rate of endosymbiont infection in the order Lepidoptera is approximately 12%, which is much lower than previously estimated. Given our limited knowledge regarding the phenotypes induced by these endosymbionts, we urge caution when extrapolating the results of a positive assays.
Dynamic adsorption of ammonia: apparatus, testing conditions, and adsorption capacities

There is a growing need for adsorbents with high capacities for adsorption of toxic gas molecules. Methods and conditions to test these materials introduce large discrepancies and overestimates (~90%) in the reported literature. This study describes a simple apparatus utilizing hand-held inexpensive gas sensors for testing adsorbents and hybrid adsorbent materials, explains possible sources for the observed discrepancies based on how the measurements are made, and provides guidelines for accurate measurements of adsorption capacity. Ammonia was the model gas and Ammonasorb™ activated carbon was the model commercial adsorbent. Inlet ammonia concentration, residence time, adsorbent pre-treatment (baking) and humidity, affected the measured adsorption capacities. Results suggest that the time lag in gas detection sensors leads to overestimated capacities. Monitoring both inlet and outlet concentrations using two calibrated sensors solved this issue. There was a direct relationship between adsorption capacity and residence time and capacities were higher at higher inlet concentrations. The size of the adsorbent particles did not show a significant effect on adsorption breakthrough, and the apparatus was able to quantify how humidity reduced the adsorption capacity.
Theoretical Modeling of Enlarging Intracranial Aneurysms

Rupture of intracranial aneurysms is the leading cause of spontaneous subarachnoid hemorrhage, which results in significant morbidity and mortality. The mechanisms by which intracranial aneurysms develop, enlarge, and rupture are unknown, and it remains difficult to collect the longitudinal patient-based information needed to improve our understanding. We suggest, therefore, that mathematical models hold considerable promise by allowing us to propose and test competing hypotheses on potential mechanisms of aneurysmal enlargement and to compare predicted outcomes with limited clinical information; in this way, we may begin to narrow the possible mechanisms and thereby focus experimental studies. Toward this end, we develop a constrained mixture model for evolving thin-walled, saccular, and fusiform aneurysms and illustrate its efficacy via computer simulations of lesions having idealized geometries. We also present a method to estimate linearized material properties over the cardiac cycle, which can be exploited when solving coupled fluid-solid interactions in a lesion
Entanglement production in bosonic systems: Linear and logarithmic growth

We study the time evolution of the entanglement entropy in bosonic systems with time-independent, or time-periodic, Hamiltonians. In the first part, we focus on quadratic Hamiltonians and Gaussian initial states. We show that all quadratic Hamiltonians can be decomposed into three parts: (a) unstable, (b) stable, and (c) metastable. If present, each part contributes in a characteristic way to the time dependence of the entanglement entropy: (a) linear production, (b) bounded oscillations, and (c) logarithmic production. In the second part, we use numerical calculations to go beyond Gaussian states and quadratic Hamiltonians. We provide numerical evidence for the conjecture that entanglement production through quadratic Hamiltonians has the same asymptotic behavior for non-Gaussian initial states as for Gaussian ones. Moreover, even for nonquadratic Hamiltonians, we find a similar behavior at intermediate times. Our results are of relevance to understanding entanglement production for quantum fields in dynamical backgrounds and ultracold atoms in optical lattices.
Enhancing Mental and Physical Health of Women through Engagement and Retention (EMPOWER): A protocol for a program of research

The Enhancing Mental and Physical health of Women through Engagement and Retention or EMPOWER program represents a partnership with the US Department of Veterans Health Administration (VA) Health Service Research and Development investigators and the VA Office of Women’s Health, National Center for Disease Prevention and Health Promotion, Primary Care-Mental Health Integration Program Office, Women’s Mental Health Services, and the Office of Patient Centered Care and Cultural Transformation. EMPOWER includes three projects designed to improve women Veterans’ engagement and retention in evidence-based care for high-priority health conditions, i.e., prediabetes, cardiovascular, and mental health. The three proposed projects will be conducted in VA primary care clinics that serve women Veterans including general primary care and women’s health clinics. The first project is a 1-year quality improvement project targeting diabetes prevention. Two multi-site research implementation studies will focus on cardiovascular risk prevention and collaborative care to address women Veterans’ mental health treatment needs respectively. All projects will use the evidence-based Replicating Effective Programs (REP) implementation strategy, enhanced with multi-stakeholder engagement and complexity theory. Mixed methods implementation evaluations will focus on investigating primary implementation outcomes of adoption, acceptability, feasibility, and reach. Program-wide organizational-, provider-, and patient-level measures and tools will be utilized to enhance synergy, productivity, and impact. Both implementation research studies will use a non-randomized stepped wedge design. EMPOWER represents a coherent program of women’s health implementation research and quality improvement that utilizes cross-project implementation strategies and evaluation methodology. The EMPOWER Quality Enhancement Research Initiative (QUERI) will constitute a major milestone for realizing women Veterans’ engagement and empowerment in the VA system. EMPOWER QUERI will be conducted in close partnership with key VA operations partners, such as the VA Office of Women’s Health, to disseminate and spread the programs nationally. The two implementation research studies described in this protocol have been registered as required: Facilitating Cardiovascular Risk Screening and Risk Reduction in Women Veterans: Trial registration NCT02991534 , registered 9 December 2016. Implementation of Tailored Collaborative Care for Women Veterans: Trial registration NCT02950961 , registered 21 October 2016.
Evidence for declining forest resilience to wildfires under climate change.

Forest resilience to climate change is a global concern given the potential effects of increased disturbance activity, warming temperatures and increased moisture stress on plants. We used a multi-regional dataset of 1485 sites across 52 wildfires from the US Rocky Mountains to ask if and how changing climate over the last several decades impacted post-fire tree regeneration, a key indicator of forest resilience. Results highlight significant decreases in tree regeneration in the 21st century. Annual moisture deficits were significantly greater from 2000 to 2015 as compared to 1985–1999, suggesting increasingly unfavourable post-fire growing conditions, corresponding to significantly lower seedling densities and increased regeneration failure. Dry forests that already occur at the edge of their climatic tolerance are most prone to conversion to non-forests after wildfires. Major climate-induced reduction in forest density and extent has important consequences for a myriad of ecosystem services now and in the future.
Correlation of Burning Rate with Spread Rate for Downward Flame Spread Over PMMA

Burning rate of solid fuel and laminar flame spread rate are both well studied topics for flame spread in downward configuration. Yet, despite well-developed theories, not much experimental data is available to correlate the two. In this work, experiments are performed under ambient conditions in downward spread configuration for a wide range of thicknesses (2 mm to 24 mm) for flat samples of Poly-Methyl Methacrylate (PMMA). The samples are held by two ceramic plates in order to obtain a two-dimensional propagation that is independent on the sample width. By analyzing videos of the experiments, the instantaneous spread rate is obtained using a recently developed MATLAB based tool. The shape of the pyrolyzing fuel is carefully measured after extinguishing the flame during a steady propagation. The spread rate and the burn angle, which is defined as the angle subtended by the pyrolyzing surface with respect of the fuel surface, are correlated, producing an expression for the burning rate in terms of the burn angle and flame spread rate. As the fuel thickness is increased, the burn angle and burning rate decrease and reach asymptotic limits for thermally thick fuels, in analogy with the spread rate limit. The comparison with data from literature suggests that in the thick limit the value of mass flux for PMMA (about 10 g/m2 s) tends to the one of non-spreading flames. The presented geometrical approach to study the downward spread problem avoids the use of the B number and local gradients in order to calculate the mass burning rate of the fuel.
Sex Differences in Early Cardiovascular and All-Cause Hospitalization Outcomes After Surviving Firearm Injury:

The majority of the burden of firearm injury in the United States is on men as compared to women. There is limited evidence regarding sex differences in short-term hospitalization outcomes after surviving firearm injury. The risk of cardiovascular and all-cause hospital readmission, length of stay (LOS), and costs within 180 days after surviving an index firearm injury was compared between males and females. A claims-based, retrospective, cohort study was performed using Nationwide Readmission Database (2013-2014) to obtain a cohort of patients who survived an index hospitalization of firearm injury. The analysis was performed in August 2017. Cox proportional hazard regression models were used to estimate hazard ratio (HR) and 95% confidence intervals (95% CIs). Among 17,594 males and 2,289 females discharged alive after index firearm injury hospitalization, 14.4% and 13.2% were readmitted within 180 days. Within 180 days, the risk of cardiovascular readmission was 3.3 times greater among males versus females (HR = 3.34, 95% CI [1.18, 9.44]. Risk of all-cause readmission among males was greater at 90 days (HR = 1.40, 95% CI [1.04, 1.87]. Patients surviving a firearm injury have a substantial risk of subsequent hospitalizations. Cardiovascular readmissions are greater among males than females during the first 6 months after injury and may be indicative of a continuing long-term risk of health and patient outcomes that contributes to the overall burden of firearm injury.
Phase II trial of circadian infusion floxuridine (FUDR) in hormone refractory metastatic prostate cancer

Circadian administration of chemotherapy has been reported to decrease toxicity and possibly enhance efficacy. Between March 1991 and December 1993, 18 evaluable patients with progressive, hormone-refractory metastatic prostate cancer were treated in this phase II trial of circadian infusion floxuridine (FUDR). The drug was delivered through a central venous catheter using a CADD-Plus computerized pump such that approximately 70% of the drug was administered between 3 and 9 p.m. and the rest (30%) was administered between 9 p.m. and 3 p.m. The dose of FUDR was 0.15 mg/kg/day × 14 days every 4 weeks. A total of 79 complete cycles was administered.
Activism and Marginalization in the AIDS Crisis

Contents Foreword * Introduction: Activism and Marginalization in the AIDS Crisis * Gatekeeping Through Media Format: Strategies of Voice for the HIV-Positive via Human Interest News Formats and Organizations * Truth and Deception in AIDS Information Brochures * The Social Construction of Target Populations and the Transformation of Prison-Based AIDS Policy: A Descriptive Case Study * The Problem with Making AIDS Comfortable: Federal Policy Making and the Rhetoric of Innocence * A Citizens' AIDS Task Force: Overcoming Obstacles * AIDS and the New Medical Gaze: Bio-Politics, AIDS, and Homosexuality * Index
Helicobacter pylori and Related Species

Helicobacter pylori, originally classified as Campylobacter pyloridis, is a spirillar or coccoid Gram-negative bacterium that infects the stomach. The incidence of H. pylori (HP) infection is decreasing, in part due to eradication, but it remains one of the most common bacterial infections worldwide and reportedly infects over half of the entire human race. Person-to-person transmission via fecal–oral, oral–oral, and gastric–oral routes accounts for most cases, but the possibility of acquisition from zoonotic or environmental sources cannot be excluded. Risk factors include young age and low socioeconomic status.
Comparison of anion gap and strong ion gap as predictors of unmeasured strong ion concentration in plasma and serum from horses.

OBJECTIVE To compare the accuracy of anion gap (AG) and strong ion gap (SIG) for predicting unmeasured strong ion concentration in plasma and serum from horses. ANIMALS 6 well-trained Standardbred horses undergoing high-intensity exercise (experimental study) and 78 horses and ponies that underwent i.v. administration of lactic acid or endotoxin, and endurance, submaximal, or high-intensity exercise. PROCEDURE Anion gap was calculated as AG = (Na+ + K+) - (Cl- + HCO3-), and SIG was calculated, using the simplified strong ion model, whereby SIG (mEq/L) = 2.24 x total protein (g/dl)/(1 + 10(6.65-pH)) - AG. The relation between AG or SIG and plasma lactate concentration was evaluated, using linear regression analysis. RESULTS Linear relations between plasma lactate concentration and AG and SIG were strong for the experimental study (r2 = 0.960 and 0.966, respectively) and the published studies (r2 = 0.914 and 0.925, respectively). The following relations were derived: AG = 1.00 x plasma lactate + 10.5; SIG = 0.99 x plasma lactate + 2.8. An AG > 15 mEq/L indicated an increased unmeasured anion concentration, whereas a SIG < -2 mEq/L indicated an increased unmeasured strong anion concentration. CONCLUSIONS AND CLINICAL RELEVANCE Anion gap and SIG can be used to predict plasma lactate concentration in horses. AG is accurate and clinically useful for estimating unmeasured strong ion concentration in horses with total protein concentrations within or slightly outside reference range, whereas SIG is more accurate in horses with markedly abnormal total protein concentrations and those of various ages and with various concentrations of albumin, globulin, and phosphate.
Neurobiology of Disruptive Behavior: A Developmental Perspective and Relevant Findings

The work presents a brief history of the rapid evolution of research on the neurobiology of development and how these advances have illuminated understanding of emotional (ER) and behavioral regulation (BR). Empirical instances are provided regarding how integration across systems is played out in behavioral neuroscience research. Findings from independent laboratories demonstrate the ways in which developmental human neuroscience-based approaches can address critical conceptual and methodological issues in the emergence of emotional and behavioral regulation.
Socioeconomic variables explain rural disparities in US mortality rates: Implications for rural health research and policy.

Abstract Objectives Rural disparities in age-adjusted mortality are growing in the United States. While socioeconomic variables have been found to explain significant variation in life expectancy across US counties, previous research has not examined the role of socioeconomic variables in explaining rural mortality disparities. The purpose of this study was to quantify the rural mortality disparity after controlling for socioeconomic variables. Methods Recursive partitioning, or tree regression, was used to fit models predicting premature mortality across counties in the United States, adjusted for age, median income, and percent in poverty in 4 time periods (from 2004 to 2012) with and without inclusion of an urban-rural variable. Results We found median income and percent in poverty explained about 50% of the variation in age-adjusted premature mortality rates across US counties in each of the four time periods. After controlling for these socioeconomic variables, rural mortality disparities largely disappeared, explaining less than 2% of the variance in premature mortality. Conclusions Addressing poverty and other socioeconomic issues should be a priority to improve health in rural communities. Interventions designed to target social determinants of health in rural areas are needed to address the growing rural mortality disparity that is largely explained by measures of poverty and income. Researchers examining rural health disparities should routinely include socioeconomic variables in their analyses.
Exploring output-based coverage for testing PHP web applications

In software testing, different testers focus on different aspects of the software such as functionality, performance, design, and other attributes. While many tools and coverage metrics exist to support testers at the code level, not much support is targeted for testers who want to inspect the output of a program such as a dynamic web application. To support this category of testers, we propose a family of output-coverage metrics (similar to statement, branch, and path coverage metrics on code) that measure how much of the possible output has been produced by a test suite and what parts of the output are still uncovered. To do that, we first approximate the output universe using our existing symbolic execution technique. Then, given a set of test cases, we map the produced outputs onto the output universe to identify the covered and uncovered parts and compute output-coverage metrics. In our empirical evaluation on seven real-world PHP web applications, we show that selecting test cases by output coverage is more effective at identifying presentation faults such as HTML validation errors and spelling errors than selecting test cases by traditional code coverage. In addition, to help testers understand output coverage and augment test cases, we also develop a tool called WebTest that displays the output universe in one single web page and allows testers to visually explore covered and uncovered parts of the output.
Analysis of evacuation destination and departure time choices for no-notice emergency events

Over the past decades, both the frequency and severity of disastrous events have increased all over the world. Thus far, many studies have focused on people’s evacuation behaviour during advance-no...
THE EFFECT OF MARIJUANA DISPENSARY OPENINGS ON HOUSING PRICES

We evaluate the effect of medical and recreational dispensary openings on housing prices in Denver, Colorado. Using an event study approach, we find that the introduction of a new dispensary within a half‐mile radius of a new home increases home prices by approximately 7.7% on average. The effect diminishes for homes further from new dispensaries but is consistent over time. Our results provide important and timely empirical evidence on the socioeconomic impacts of marijuana legalization. (JEL R32, R38, R5)
A Novel Approach to Increase Dynamic Fracture Toughness of Additively Manufactured Polymer

An experimental study is performed to investigate the dynamic fracture of additive manufactured Acrylonitrile Butadiene Styrene (ABS). A single edge notched bending (SENB) specimen with three orientations, namely horizontal builds with 45°/−45° (H45), 0°/90° (H90) raster orientations, and vertical builds with layers perpendicular to the pre-crack (V0) are considered for this study. In addition, a novel toughening mechanism is explored by changing the surface topology to deflect the crack paths. A modified split Hopkinson pressure bar with a copper pulse shaper (to increase the raising time of incident loading pulse) is used to conduct a three-point bend impact experiment to characterize the dynamic fracture initiation toughness and crack dynamics of 3D printed specimens. Real-time crack initiation and propagation is captured by using a high-speed video camera. Using the load history diagram, accurate fracture initiation load is found to determine dynamic fracture initiation toughness. Fracture initiation toughness is increased by 138% for a V0 specimen configuration compared to H90. Three different sized circular patterns (with diameters of 1, 1.75 and 2.5 mm) and a square pattern (with a length of 1.53 mm) are considered to observe the effect of surface topology on the dynamic fracture initiation toughness. Introducing surface pattern to the specimen increases the fracture toughness by 58% as compared to specimens without surface pattern. Surface pattern also exhibits two steps of crack growth and decreases the initial crack propagation velocity significantly for all three orientations. Additionally, higher fracture initiation toughness is achieved with the increase in the size of the pattern and the change of the pattern shape.
[Semi-quantitative risk assessment of human infection with H7N9 avian influenza epidemic in Zhejiang province].

Objective To assess the risk of local outbreaks of H7N9 avian influenza infection in Zhejiang province and to explore the semi-quantitative assessment method for public health risks in emergency. Methods Risk index system of human infection with H7N9 avian influenza caused by local transmission were reviewed. The weights of indexes were calculated by analytic hierarchy process, which was combined with the TOPSIS method to calculate the risk comprehensive index. Results Four primary indexes and 23 secondary indexes were identified for risk assessment in local outbreaks of H7N9 avian influenza infection. The weights ranked on the top five were:morbidity (0.0972), closure measures (0.0718), sterilization measures (0.0673), fatality rate (0.0651), and epidemic spread (0.0616). The comprehensive index of the risk of local outbreaks of H7N9 avian influenza ranged from high to low were Hangzhou (0.5910), Shaoxing (0.5711), Jiaxing (0.5199), Taizhou (0.5198), Huzhou (0.4662), Ningbo (0.3828), Wenzhou (0.3719), Jinhua (0.3392), Lishui (0.2727), Quzhou (0.2001) and Zhoushan (0.0508). Conclusions A semi-quantitative method has been established in this study, which provides scientific basis for prevention and control of H7N9 avian influenza epidemic in Zhejiang province.
Computationally Efficient, Multi-Domain Hybrid Modeling of Surface Integrity in Machining and Related Thermomechanical Finishing Processes

Abstract In order to enable more widespread implementation of sophisticated process modeling, a novel, rapidly deployable multi-physics hybrid model of surface integrity in finishing operations is proposed. Rather than modeling detailed chip formation mechanics, as is common in numerical models, the proposed models integrates existing analytical and semi-empirical models of the plastic, elastic, thermal and thermodynamic domains. Using this approach, highly complex surface integrity phenomena such as residual stresses, grain size, phase composition, microhardness profile, etc. can be accurately predicted in a manner of seconds. It is envisioned that this highly efficient modeling scheme will drive new innovations in surface engineering.
Particle image velocimetry validation for quantifying bedload movement

A Particle Image Velocimetry (PIV) technique was validated for predicting movements of bedload particles. Synthetic images, similar to those from testing a physical model, were created with differe...
Hydrophilic polyurethane matrix promotes chondrogenesis of mesenchymal stem cells.

Abstract Segmental polyurethanes exhibit biphasic morphology and can control cell fate by providing distinct matrix guided signals to increase the chondrogenic potential of mesenchymal stem cells (MSCs). Polyethylene glycol (PEG) based hydrophilic polyurethanes can deliver differential signals to MSCs through their matrix phases where hard segments are cell-interactive domains and PEG based soft segments are minimally interactive with cells. These coordinated communications can modulate cell–matrix interactions to control cell shape and size for chondrogenesis. Biphasic character and hydrophilicity of polyurethanes with gel like architecture provide a synthetic matrix conducive for chondrogenesis of MSCs, as evidenced by deposition of cartilage-associated extracellular matrix. Compared to monophasic hydrogels, presence of cell interactive domains in hydrophilic polyurethanes gels can balance cell–cell and cell–matrix interactions. These results demonstrate the correlation between lineage commitment and the changes in cell shape, cell–matrix interaction, and cell–cell adhesion during chondrogenic differentiation which is regulated by polyurethane phase morphology, and thus, represent hydrophilic polyurethanes as promising synthetic matrices for cartilage regeneration.
Revisiting Landscape Analysis in Deep Neural Networks: Eliminating Decreasing Paths to Infinity

Traditional landscape analysis of deep neural networks aims to show that no sub-optimal local minima exist in some appropriate sense. From this, one may be tempted to conclude that descent algorithms which escape saddle points will reach a good local minimum. However, basic optimization theory tell us that it is also possible for a descent algorithm to diverge to infinity if there are paths leading to infinity, along which the loss function decreases. It is not clear whether for non-linear neural networks there exists one setting that no bad local-min and no decreasing paths to infinity can be simultaneously achieved. In this paper, we give the first positive answer to this question. More specifically, for a large class of over-parameterized deep neural networks with appropriate regularizers, the loss function has no bad local minima and no decreasing paths to infinity. The key mathematical trick is to show that the set of regularizers which may be undesirable can be viewed as the image of a Lipschitz continuous mapping from a lower-dimensional Euclidean space to a higher-dimensional Euclidean space, and thus has zero measure.
Integrating Supply and Demand Perspectives for a Large-Scale Simulation of Shared Autonomous Vehicles:

Transportation Network Companies (TNCs) have been steadily increasing the share of total trips in metropolitan areas across the world. Micro-modeling TNC operation is essential for large-scale tran...
Strategies of desiccation tolerance vary across life phases in the moss Syntrichia caninervis.

PREMISE Desiccation tolerance (DT) is a widespread phenomenon among land plants, and variable ecological strategies for DT are likely to exist. Using Syntrichia caninervis, a dryland moss and model system used in DT studies, we hypothesized that DT is lowest in juvenile (protonemal) tissues, highest in asexual reproductive propagules (gemmae), and intermediate in adults (shoots). We tested the long-standing hypothesis of an inherent constitutive strategy of DT in this species. METHODS Plants were rapidly dried to levels of equilibrating relative humidity (RHeq) ranging from 0 to 93%. Postrehydration recovery was assessed using chlorophyll fluorescence, regeneration rates, and visual tissue damage. For each life phase, we estimated the minimum rate of drying (RoDmin ) at RHeq = 42% that did not elicit damage 24 h postrehydration. RESULTS DT strategy varied with life phase, with adult shoots having the lowest RoDmin (10-25 min), followed by gemmae (3-10 h) and protonema (14-20 h). Adult shoots exhibited no detectable damage 24 h postrehydration following a rapid-dry only at the highest RHeq used (93%), but when dried to lower RHs the response declined to <50% of control fluorescence values. Notably, immediately following rehydration (0 h postrehydration), shoots were damaged below control levels of fluorescence regardless of the RHeq, thus implicating damage. CONCLUSIONS Life phases of the moss S. caninervis had a range of strategies from near constitutive (adult shoots) to demonstrably inducible (protonema). A new response variable for assessing degree of DT is introduced as the minimum rate of drying from which full recovery occurs.
Overground gait training using virtual reality aimed at gait symmetry.

Abstract This study investigated if training in a virtual reality (VR) environment that provides visual and audio biofeedback on foot placement can induce changes to spatial and temporal parameters of gait during overground walking. Eighteen healthy young adults walked for 23 min back and forth on an instrumented walkway in three different conditions: (i) real environment (RE), (ii) virtual environment (VE) with no biofeedback, and (iii) VE with biofeedback. Visual and audio biofeedback while stepping on virtual footprint targets appearing along a straight path encouraged participants to walk with an asymmetrical step length (SL). A repeated-measures, one-way ANOVA, followed by a pairwise comparison post-hoc analysis with Bonferroni's correction, was performed to compare the step length difference (SLD), stance phase percentage difference (SPPD), and double-support percentage difference (DSPD) between early and late phases of all walking conditions. The results demonstrate the efficacy of the VE biofeedback system for training asymmetrical gait patterns. Participants temporarily adapted an asymmetrical gait pattern immediately post-training in the VE. Induced asymmetries persisted significantly while later walking in the RE. Asymmetry was significant in the spatial parameters of gait (SLD) but not in the temporal parameters (SPPD and DSPD). This paper demonstrates a method to induce unilateral changes in spatial parameters of gait using a novel VR tool. This study provides a proof-of-concept validation that VR biofeedback training can be conducted directly overground and could potentially provide a new method for treatment of hemiplegic gait or asymmetrical walking.
Industrialization from scratch: The “Construction of Third Front” and local economic development in China's hinterland

Abstract This paper investigates whether temporary subsidies to the manufacturing sector at an early stage of structural transformation stimulate economic development. We study the “Construction of Third Front” (TF), a massive yet short-lived industrialization campaign in China's under-developed hinterland. Motivated by defense considerations, location choices of TF projects followed a peculiar set of criteria, which generates plausibly exogenous variation in manufacturing capacity before market reforms started in the mid-1980s. We find initial advantages in manufacturing have long-run positive effects on the structural transformation of the local economy. The effects are driven by new entrants in the private sector, consistent with the existence of local agglomeration economics. However, there is no evidence that agglomeration forces are stronger in initially less-developed regions. While the TF reduced regional inequality, it likely hurt the aggregate efficiency.
Perusall (www.perusall.com): Read, connect, discuss!

Perusall. (n.d.). Getting started. https://support.perusall.com/hc/en-us/articles/360034534193-Getting-started.Online programs and classes are increasingly offered in higher education (Ni et al., 2...
Single-session versus two-session placement of chest port and gastrostomy tube in patients with head and neck cancer: Is there any difference in the device-related early infection rates?

BackgroundIt is unknown whether placement of a chest port (port) and a gastrostomy tube (G-tube) in a single session increases the risk of the early device infections in patients with head and neck...
Esrrγa regulates nephron development and ciliogenesis by controlling prostaglandin synthesis and cooperation with Ppargc1a

Cilia are essential for the ontogeny and function of many tissues, including the kidney. In mammals, Esrr{gamma} has been previously established as a significant determinant of renal health, with decreased expression linked to age related dysfunction, cyst formation, and kidney disease. Here, we report that the Esrr{gamma} vertebrate ortholog estrogen related receptor gamma a (esrr{gamma}a) is essential for proper cell fate choice within kidney functional units (nephrons) as well as ciliogenesis. Deficiency of esrr{gamma}a resulted in nephrons with alterations in proximodistal segmentation and a decreased multiciliated epithelial cell populace. Surprisingly, esrr{gamma}a deficiency disrupted renal ciliogenesis and caused a similar abrogation within the developing node and otic vesicle--all defects that occurred independently of changes in cell polarity or basal body organization. These phenotypes were consistent with interruptions in prostaglandin signaling, and we found that ciliogenesis was rescued in esrr{gamma}a deficient embryos with exogenous PGE2 or through overexpression of the cyclooxygenase enzyme Ptgs1. Through genetic interaction studies, we found that peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (ppargc1a), which acts upstream of Ptgs1-mediated prostaglandin synthesis, has a synergistic relationship with esrr{gamma}a in the ciliogenic pathway. These data position esrr{gamma}a as a novel link between ciliogenesis and nephrogenesis through regulation of prostaglandin signaling and cooperation with ppargc1a, and highlight esrr{gamma}a as a potential new target for future ciliopathic treatments.
Innovation diffusion and long waves: Further evidence

Abstract The mean rate of innovation diffusion in the U.S. is compared with the long wave of prices. A clear relationship is evident, with the long waves led by the innovation waves. Kondratiev peaks mark the periods of instability that accompany market saturation and the onset of technological restructuring.
Discussion by J.A. Hartigan

Dr. Murtagh paints a grim picture of the typical astronomical database, containing data of various types and complexity from various sources with varying reliability. And I do not think much comfort is available in standard statistical theory for handling such data; most multivariate analysis presupposes data to be in a rectangular data matrix and begins by assuming that points are sampled independently from some population. So, yes, usually we begin by getting data into shape by crude procrustean means, lopping off bits of data in one place, and interpolating bits of data elsewhere.
Mens sana: the growth of mental health in the American College Health Association.

Abstract In 1910, the first college mental health service sought to help college students with personality development and building a healthy mind. In 1920, the meeting that founded the American College Health Association (ACHA) identified “mental hygiene” as important, although a separate Mental Health Section was not established in ACHA until 1957. Between 1920 and 1960, a series of national meetings helped define the role and functioning of college mental health and counseling services. Most colleges employed a multidisciplinary staff of psychologists, psychiatric social workers, and psychiatrists to provide clinical services for students and consultation and education for faculty and staff. Mental health services on college campuses grew rapidly in the 1960s and 1970s, leading to discussions in the late 20th century of the use of brief psychotherapies, prevention and treatment of drug and alcohol abuse, prevention of suicide and homicide, the use of psychotropic medications, and effective campus inter...
A Super-Programming Technique for Large Sparse Matrix Multiplication on PC Clusters

The multiplication of large spare matrices is a basic operation for many scientific and engineering applications. There exist some high-performance library routines for this operation. They are often optimized based on the target architecture. The PC cluster computing paradigm has recently emerged as a viable alternative for high-performance, low-cost computing. In this paper, we apply our super-programming approach [24] to study the load balance and runtime management overhead for implementing parallel large matrix multiplication on PC clusters. For a parallel environment, it is essential to partition the entire operation into tasks and assign them to individual processing elements. Most of the existing approaches partition the given sub-matrices based on some kinds of workload estimation. For dense matrices on some architectures estimations may be accurate. For sparse matrices on PC, however, the workloads of block operations may not necessarily depend on the size of data. The workloads may not be well estimated in advance. Any approach other than run-time dynamic partitioning may degrade performance. Moreover, in a heterogeneous environment, statically partitioning is NP-complete. For embedded problems, it also introduces management overhead. In this paper We adopt our super-programming approach that partitions the entire task into medium-grain tasks that are implemented using super-instructions; the workload of super-instructions is easy to estimate. These tasks are dynamically assigned to member computer nodes. A node may execute more than one super-instruction. Our results prove the viability of our approach.
The use of the semiprogrammed workbook as a self-learning device in teaching reproductive biology.

Abstract The ability of a group of freshman and junior medical students to learn human cytogenetics using a semiprogrammed workbook was measured and the results compared with student reading ability (vocabulary and comprehension) as measured by the Nelson-Denny reading test. Three freshman and one junior control groups (to test different variables of the experimental design) were compared to a freshman and a junior treatment group, using a post-test only method. Both freshman and junior treatment groups showed significant growth in knowledge (p
Mobile Antiphase Domains in Lightly Doped Lanthanum Cuprate

Light hole doping of lanthanum cuprate strongly suppresses the onset of antiferro-magnetic (AF) order. Surprisingly, it simultaneously suppresses the extrapolated zero temperature sublattice magnetization. 139La NQR results in-lightly doped La2Cu1−xLixO4 demonstrate that these effects are independent of the details of the mobility of the added holes. We propose a model in which doped holes phase separate into charged domain walls that surround “antiphase” domains. These domains are mobile down to ∼30 K, at which point they either become pinned to the lattice or evaporate as their constituent holes become pinned to dopant impurities.
Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR.

Human immunodeficiency virus (HIV) protease inhibitors (PIs) produce profound and unpredictable drug-drug interactions (DDIs) that cannot be explained fully by their inhibition/inactivation of CYP3A enzymes. Delineating and quantifying the CYPs and transporters inducible by PIs are crucial in developing an integrative mechanistic understanding and prediction of PI-based DDIs. To do so, two LC-MS/MS cocktail assays were modified and validated simultaneously to quantify the CYP activity of CYP3A, 2B6, 2C8, 2C9, 2C19, 1A, 2E1, 2A6 and 2D6 enzymes. These new assays were applied to evaluate the induction potential of eight PIs in microsomes isolated from PI-treated human hepatocytes. The mRNA expression of these CYPs and transporters (OATP1B1, OATP1B3, OATP1A2, MDR1, MRP2 and MRP4) was also evaluated using relative RT-PCR. The majority of PIs were net inducers of CYP3As and 2B6 at both the mRNA and activity level (> 2-fold), while ritonavir, saquinavir, nelfinavir or lopinavir did not induce CYP3A activity ( 2-fold) by the PIs. Amprenavir was the most potent net inducer. In conclusion, our validated cocktail assays can be implemented to comprehensively quantify CYP activities in human liver microsomes and hepatocyte studies. The results also provide the much needed data on the net induction potential of the PIs for hepatic CYPs and transporters. A qualitative agreement was observed between our results and published PI-based DDIs, suggesting that human hepatocytes are a useful platform for more extensive and quantitative in vitro-in vivo prediction of PI-based DDIs.
Mutational analysis of the S21 pinholin

Summary Lambdoid phage 21 has the prototype pinholin-SAR endolysin lysis system, which is widely distributed among phages. Its prototype pinholin, S2168, triggers at an allele-specific time to form small, heptameric lesions, or pinholes, in the cytoplasmic membrane, thus initiating lysis. S2168 has two transmembrane domains, TMD1 and TMD2. Only TMD2 is required for the formation of pinholes, whereas TMD1 acts as an inhibitor of TMD2 and must be externalized to the periplasm in the lytic pathway. Previously we provided evidence that S2168 first accumulates as inactive dimers with both transmembrane domains embedded in the bilayer. Here we analyse an extensive collection of S21 mutants to identify residues and domains critical to the function and regulation of the pinholin. Evidence is presented indicating that, within the inactive dimer, TMD1 acts in trans as an inhibitor of the lethal function of TMD2. A wide range of phenotypes, from absolute lysis defectives to accelerated lysis triggering, are observed for mutations mapping to each topological domain. The pattern of phenotypes allows the generation of a model for the structure of the inactive dimer. The model identifies the faces of the two transmembrane domains involved in intramolecular and intermolecular interactions, as well as interaction with the lipid.
GAS PHASE ATOMIC HYDROGEN-INDUCED HYDROGENATION OF CYCLOHEXENE ON THE NI(100) SURFACE

Gas phase hydrogen atoms add to adsorbed cyclohexene at 100 K on the Ni(100) surface, resulting in cyclohexane formation during subsequent TPR (temperature-programmed reaction) experiments. No C−C ...
Occurrence of multidrug resistant Salmonella in antimicrobial-free (ABF) swine production systems

This cross-sectional study was conducted to determine the prevalence and antimicrobial resistance of Salmonella species in swine reared in the intensive (indoor) and extensive (outdoor) ABF production systems at farm and slaughter in North Carolina, U.S.A. We sampled a total of 279 pigs at farm (extensive 107; intensive 172) and collected 274 carcass swabs (extensive 124; intensive 150) at slaughter. Salmonella species were tested for their susceptibility against 12 antimicrobial agents using the Kirby-Bauer disk diffusion method. Serogrouping was done using polyvalent and group specific antisera. A total of 400 salmonellae were isolated in this study with a significantly higher Salmonella prevalence from the intensive (30%) than the extensive farms (0.9%) (P<0.001). At slaughter, significantly higher Salmonella was isolated at the pre- and post-evisceration stages from extensively (29% pre-evisceration and 33.3% post-evisceration) than the intensively (2% pre-evisceration and 6% post-evisceration) reared swine (P<0.001). The isolates were clustered in six serogroups including B, C, E1, E4, G and R. Highest frequency of antimicrobial resistance was observed against tetracycline (78.5%) and streptomycin (31.5%). A total of 13 antimicrobial resistance patterns were observed including the pentaresistant strains with ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline resistance pattern observed only among isolates from the intensive farms (n=28) and all were serotype Salmonella typhimurium var. Copenhagen. In conclusion, this study shows that multidrug resistant Salmonella are prevalent in ABF production systems despite the absence of antimicrobial selection pressure. In addition, it also highlights the possible role played by slaughterhouse and other environmental factors in the contamination and dissemination of antimicrobial resistant Salmonella in ABF production systems.