cssi/SciSciGPT-SciSciNet huggingface dataset:
The time-image and Deleuze's transcendental experience

In this paper I examine the meaning of Deleuze's “transcendental empiricism” by means of the kind of experience that his project opens up for us – an experience that I want to call transcendental. Primarily on the basis of his works on cinema, famously dedicated to freely investigating Bergson's thought, I argue that Deleuze's notion of the time-image, together with his search for its real and necessary conditions, consists in the liberation of experience from its Kantian limitative conditioning. I then examine both the new kind of subjectivity (the fissured ego) that emerges from this enlarged experience and the new conception of temporality (time out of joint) that subtends it. Finally, I try to bring out the concrete relations between (transcendental) experience, thought and the brain that Deleuze brings to light in his analysis of great cinema's reinvention of the relationship between time and movement.
Implementation of hand geometry at Purdue University's Recreational Center: an analysis of user perspectives and system performance

This paper discusses the implementation issues of installing a commercially available hand geometry system in the current infrastructure of Purdue University's Recreational Sports Center. In addition to a performance analysis of the system, a pre- and post- data collection survey was distributed to the 129 test subjects gathering information on perceptions of biometrics, in particular hand geometry, as well as participants' thoughts and feelings during their interaction with the hand geometry device. The results of the survey suggest that participants were accepting of hand geometry. Additionally, analyses of the participants' survey responses revealed that 93% liked using hand geometry, 98% thought it was easy to use, and 87% preferred it to the existing card-based system, while nobody thought the device invaded their personal privacy. System performance achieved a 3-try match rate of 99.02% (FRR 0.98%) when "gaming"/potential impostor attempts were removed from analysis. The failure to enroll rate was zero. Statistical analyses exposed a significant difference in the scores of attempts made by users with prior hand geometry usage, and subjects that could not straighten out their hand on the device. However, there were no statistical difference in the effects of rings/no rings, improper hand placements/proper hand placements, or gender on hand geometry' score.
The Effects of an Afternoon Nap on Episodic Memory in Young and Older Adults.

Study objectives In young adults, napping is hypothesized to benefit episodic memory retention (eg, via consolidation). Whether this relationship is present in older adults has not been adequately tested but is an important question because older adults display marked changes in sleep and memory. Design Between-subjects design. Setting Sleep laboratory at Emory University School of Medicine. Participants Fifty healthy young adults (18-29) and 45 community-dwelling older adults (58-83). Intervention Participants were randomly assigned to a 90-minute nap opportunity or an equal interval of quiet wakefulness. Measurements and results Participants underwent an item-wise directed forgetting learning procedure in which they studied words that were individually followed by the instruction to "remember" or "forget." Following a 90-minute retention interval filled with quiet wakefulness or a nap opportunity, they were asked to free recall and recognize those words. Young adults retained significantly more words following a nap interval than a quiet wakefulness interval on both free recall and recognition tests. There was modest evidence for greater nap-related retention of "remember" items relative to "forget" items for free recall but not recognition. Older adults' memory retention did not differ across nap and quiet wakefulness conditions, although they demonstrated greater fragmentation, lower N3, and lower rapid eye movement duration than the young adults. Conclusions In young adults, an afternoon nap benefits episodic memory retention, but such benefits decrease with advancing age.
Intracellular transport and compartmentation of phosphate in plants

Phosphate (Pi) is an essential macronutrient with structural and metabolic roles within every compartment of the plant cell. Intracellular Pi transporters direct Pi to each organelle and also control its exchange between subcellular compartments thereby providing the means to coordinate compartmented metabolic processes, including glycolysis, photosynthesis, and respiration. In this review we summarize recent advances in the identification and functional analysis of Pi transporters that localize to vacuoles, chloroplasts, non-photosynthetic plastids, mitochondria, and the Golgi apparatus. Electrical potentials across intracellular membranes and the pH of subcellular environments will also be highlighted as key factors influencing the energetics of Pi transport, and therefore pose limits for Pi compartmentation.
“They will go like I did”: How parents think about college for their young children in the context of rising costs

Abstract Rising college costs and student loan burdens have triggered national debates about whether a college degree is “worth it.” Parents raising children in the midst of these debates may be evaluating the value of a college degree relative to its costs and adjusting their educational expectations for their children, shaping future generations' socialization toward college. In this context, it is unclear how theoretical models on college attendance decision-making perform in explaining parents' thoughts about college for their children. This qualitative study elicited early perspectives on college through in-depth interviews with 37 parents of kindergarten children from one school district in a mid-sized, Midwestern city. Almost unanimously, lower-income parents with some college education saw a college degree as a catalyst of their children's upward mobility, though very few thought they could help their children afford college. Higher-income parents more often expressed doubts about pursuing a college degree or the value of that degree acquired with debt.
Ontogeny and regulation of growth hormone- and prolactin- secreting cells in the rat: analysis at the single cell level using reverse hemolytic plaque assays

12 INTRODUCTION 14 MATERIALS AND METHODS 15 Animals and cell culture 15 RHPA 16 ICC 18 RESULTS 21 DISCUSSION 26 REFERENCES 33 ACKNOWLEDGMENTS 36 SECTION II; ONTOGENY OF PROLACTIN CELLS IN NEO37 NATAL RATS; INITIAL PROLACTIN SECRETORS ALSO RELEASE GROWTH HORMONE
Asfotase alfa treatment for 1 year in a 16 year-old male with severe childhood hypophosphatasia

We describe the clinical outcome of asfotase alfa therapy in a 16-year-old boy with severe childhood hypophosphatasia (HPP), who began therapy at age 15 years. The patient was diagnosed with HPP at age 2 years when he presented with genu varum and premature loss of primary teeth. He had a history of multiple fractures requiring 16 orthopedic surgeries with rod and pin placement in his lower extremities. He had chronic skeletal pain and used cane to ambulate with great difficulty. His height Z score at age 15 years was − 5. He had severe scoliosis and deformity of both legs. Bone radiograph showed hypomineralization and characteristic “tongues” of radiolucency in the distal radius and ulna. His serum alkaline phosphatase level was stable, with elevated serum pyridoxal 5′-phosphate and urine phosphoethanolamine, consistent with HPP. He was started on asfotase alfa 2 mg/kg given subcutaneously thrice weekly. He had marked clinical improvement in mobility with no report of pain after 3 months of treatment. At 6 month, he walked without cane and participated in outdoor activities with peers. Bone radiograph at 6 months showed striking improvement in previous radiolucent areas. At 9 months, his annualized growth velocity was 9.5 cm/year, while growth velocity of arm span was 12 cm/year. However, at 12 months, he was noted to have worsening scoliosis from 60 degrees before therapy to 110 degrees, with a slight decrease in height, necessitating a spinal fusion surgery. In conclusion, treatment with asfotase alfa significantly improved physical function, pain, overall quality of life, and skeletal radiographic findings in this patient. Close monitoring for progression of scoliosis in adolescents with HPP treated with asfotase alfa is recommended.
Two Strategies for Qualitative Content Analysis: An Intramethod Approach to Triangulation:

The overarching aim of qualitative research is to gain an understanding of certain social phenomena. Qualitative research involves the studied use and collection of empirical materials, all to describe moments and meanings in individuals' lives. Data derived from these various materials require a form of analysis of the content, focusing on written or spoken language as communication, to provide context and understanding of the message. Qualitative research often involves the collection of data through extensive interviews, note taking, and tape recording. These methods are time- and labor-intensive. With the advances in computerized text analysis software, the practice of combining methods to analyze qualitative data can assist the researcher in making large data sets more manageable and enhance the trustworthiness of the results. This article will describe a novel process of combining two methods of qualitative data analysis, or Intramethod triangulation, as a means to provide a deeper analysis of text.
Individual transportation decisions under conditions of risk and uncertainty

This study explores the influence of three factors on a person’s decision to drive in winter weather: destination, affected area, and caution level. Participants (n = 555) completed an online survey that included scenarios with text of a simulated radio message involving a character named Mike. After the scenario, participants answered Likert-scaled questions related to their intention to drive (what would you do) and their recommended behavior for others (what should Mike do). There was a significant effect of destination and caution level on the decision to drive. Participants were more likely to respond that they would drive if the destination was work rather than dinner, and if the caution statement was “exercise caution” rather than “do not drive.” There were similar significant effects of destination and caution level on what the scenario character should do. It is recommended that a clear directive be included in warning messages to encourage drivers to stay off the roadways during hazardous weather.
Acute Cardiac Effects of Severe Pre-Eclampsia.

Abstract Background Pre-eclampsia with severe features (PEC) is a pregnancy-specific syndrome characterized by severe hypertension and end-organ dysfunction, and is associated with short-term adverse cardiovascular events, including heart failure, pulmonary edema, and stroke. Objectives The authors aimed to characterize the short-term echocardiographic, clinical, and laboratory changes in women with PEC, focusing on right ventricular (RV) systolic pressure (RVSP) and echocardiographic-derived diastolic, systolic, and speckle tracking parameters. Methods In this prospective observational study, the authors recruited 63 women with PEC and 36 pregnant control patients. Results The PEC cohort had higher RVSP (31.0 ± 7.9 mm Hg vs. 22.5 ± 6.1 mm Hg; p Conclusions Women with PEC have higher RVSP, higher rates of abnormal diastolic function, decreased global RVLSS, increased left-sided chamber remodeling, and higher rates of peripartum pulmonary edema, when compared with healthy pregnant women.
Dante’s 3-Sphere Universe

Dante Alighieri (1265–1321) AD wrote what is now considered one of the greatest works of world literature, the Divine Comedy — an allegorical vision of Christian afterlife. The focus here is a description of a universe that includes the Empyrean, which, among Christian poets, is the abode of God or the firmament. Dante constructs the Empyrean as a mirror image of the classical Aristotle universe, and then “glues their 2-sphere boundaries” to form a 3-sphere. We essentially follow the article Dante and the 3-sphere by Mark Peterson, American Journal of Physics 47 (1979).
Telecommunications and the Scope of the Market in Services

The promised liberalization within the European Economic Community in 1992 is likely to be the most significant economic event of the coming decade. Should this transformation actually occur, it will at last create a market, the world’s largest, appropriate to the economic potential of the region. The free movement of goods, people, and information among 325 million consumers, workers, and stockholders promises to create enormous wealth for Europeans and enormous opportunities for the rest of us. I would like to focus on the role of telecommunications services in this transformation, which I believe is far more vital than is generally recognized. Note I use the word “services.” Much has been written and said about the market for telecommunications equipment, including the “threat” of the Japanese and American manufacturers. I am going to ignore completely the trade in telecommunications equipment problem; I view this market as mature, in which transactions are few in number but large in value, very highly politicized, and well studied by others. What I find of far greater interest is the role of telecommunications services in defining the scope of the market of services, which, after, all is what 1992 is all about.
Temporomandibular Pain Case Presentation

A 23-year-old female presents with a 4-week complaint of pain in the right preauricular/auricular area and limited range of mandibular motion. She has no previous history of similar discomfort. She denies any significant blunt trauma to the face or mandible. By history she was eating a bagel when she had acute pain and a sensation of instability in her right jaw joint. She has noticed a slight change in her occlusion with an inability to make her right posterior teeth touch (posterior open bite). Over time she has noticed that she has slowly regained some of her range of motion, but she still has significant pain especially with opening her mouth. Upon careful history taking, she does have a history of occasional “clicking” of her jaw joints. The noise was not accompanied by any pain or limited range of motion. She specifically denies any parafunctional habits such as clenching or bruxism. She did not seek any treatment until now. She has tried OTC analgesics with limited success in pain relief. She is very concerned about her limited range of motion. In addition the pain that she is experiencing is resulting in lost productivity.
Developing and Sustaining Sustainability-Related Academic Programming: Observations of Emerging Practices

The purpose of this paper is to provide an overview and summary of selected sustainability-related academic programs and certificates delivered by universities and colleges located in the same geographic area (Grand Rapids, Michigan, U.S.). Holistic and practical dimensions of creating and sustaining educational programs are evaluated, and emerging outcomes from universities with a history of prosperous sustainability studies programs are provided as models of applicability. The possible effects of the level of formalizing sustainability in higher education and different aspects of academic-level sustainability programming at universities and colleges in a single geographic region were studied in a comparative perspective. The study focused on the role of internal and external leadership, political and appointed officials, networking factors of various stakeholders, demand for sustainability in education, and the resources commitment in staffing. We evaluated each element in the context of sustainability in education and longevity and self-support. These findings and the concept of successfully developing and sustaining sustainability‑related academic programs in Grand Rapids (MI) are examined within a broad and holistic context encompassing educational, programmatic, socioeconomic, organizational, and leadership dimensions. While further research is warranted, predictably, all elements performed well and added value to the conceptual framework of developing and sustaining sustainability-related academic programming with potential lessons applicable to the programmatic approaches to education domestically and abroad.
Evaluating Simpler User Interfaces for Computer Programming Educational Tools

This project introduces and studies a redesign of the user interface for line_explorer, an instructional tool used in introductory programming courses. In this preliminary test students worked with one of two display options for the instructions: the first provided all instructional information at once, while the other displayed the instructional information in phases. Findings from the study confirmed that an interface can affect the comfort level of the user, and thus can influence the effectiveness of the tool. Results from the research will aid in identifying parameters that need to be improved or adapted to line_explorer and other programming instructional tools to encourage better comprehension of programming concepts, as well as improve the willingness of students to use these instructional tools.
Processing Different Kinds of Expository Text: An Investigation of Students’ Strategy Use in Postsecondary Education

Students’ strategic processing is foundational to reading and success and can inform reading and instruction in postsecondary education. The present study explored students’ strategy use when readi...
Internet economics

From the Publisher: "The Internet raises new questions about the economics of networks and forces us to re-examine old questions in a new light. As such, the papers assembled here constitute some of the seminal contributions to a new economic sub-field, by the scholars who were among the first to notice and investigate these new questions. This book also explores issues which are central to the current policy debate surrounding the current re-write of this country's communications laws. The material presented is extremely relevant to a broad audience, including in particular policy-makers, as well as the many business audiences which have a stake in the evolution of communication networks. This work is an extremely significant contribution." -- Francois Bar, Assistant Professor of Communication, Stanford University The Internet has rapidly become an important element of the economic system. The lack of accepted metrics for economic analysis of Internet transactions is therefore increasingly problematic. This book, one of the first to bring together research on Internet engineering and economics, attempts to establish such metrics. The chapters, which developed out of a 1995 workshop held at MIT, include architectural models and analyses of Internet usage, as well as alternative pricing policies. The book is organized into six sections: 1) Introduction to Internet Economics, 2) The Economics of the Internet, 3) Interconnection and Multicast Economics, 4) Usage Sensitive Pricing, 5) Internet Commerce, and 6) Internet Economics and Policy. Contributors: Loretta Anania, Joseph P. Bailey, Nevil Brownlee, David Carver, David Clark, David W. Crawford, Ketil Danielsen, Deborah Estrin, Branko Gerovac, David Gingold, Jiong Gong, Alok Gupta, Shai Herzog, Clark Johnson, Martyne M. Hallgren, Frank P. Kelly, Charlie Lai, Alan K. McAdams, Jeffrey K. MacKie-Mason, Lee W. McKnight, Gennady Medvinsky, Liam Murphy, John Murphy, B. Clifford Neuman, Jon M. Peha, Joseph Reagle, Mitrabarun Sarkar, Scott Shenker, Marvin A. Sirbu, Richard Jay Solomon, Padmanabhan Srinagesh, Dale O. Stahl, Hal R. Varian, Qiong Wang, Martin Weiss, Andrew B. Whinston.
Implementation of the PHA Pulmonary Hypertension Care Center Accreditation Program

In the previous issue of Advances in Pulmonary Hypertension, Dr Studer discussed the emerging evidence suggesting that patients with pulmonary hypertension (PH) managed by specialized centers have ...
An Atypical Case of Emphysematous Cystitis in a Young Non-Diabetic Patient

Emphysematous cystitis is a rare, but severe infection of the urinary tract which is mostly found in older women with uncontrolled diabetes. A 34-year-old non-diabetic male with a past medical history of refractory hepatic encephalopathy presented with fever and increased lower abdominal pain for 1 day. Computed tomography (CT) scan demonstrated multiple gas foci in a diffuse collection of gas within the thickened bladder wall suggestive of emphysematous cystitis, and urine culture revealed Klebsiella pneumoniae as the causative agent. The infection resolved with bladder drainage and irrigation and antibiotic therapy in 1 week. An atypical case of emphysematous cystitis in a young non-diabetic man is reported. Early diagnosis and prompt treatment are essential to achieving a favorable prognosis and to preventing a potentially fatal condition. World J Nephrol Urol. 2019;8(1):17-18 doi: https://doi.org/10.14740/wjnu374
Late Recurrences Following Radical Cystectomy Have Distinct Prognostic and Management Considerations.

Purpose:Disease recurrence after radical cystectomy generally occurs within 2 years and has a poor prognosis. Less well defined are the outcomes in patients who experience a late recurrence (more t...
[Formula: see text]Survey methods for neuropsychologists: A review of typical methodological pitfalls and suggested solutions.

Objective: Survey research has enjoyed an increase in popularity, in part due to the availability of user-friendly software programs for online survey development and deployment. Neuropsychologists...
Establishing an RMS von Mises Stress Error Bound for Random Vibration Analysis

The root mean square (RMS) von Mises stress is a criterion used for assessing the reliability of structures subject to stationary random loading. This work investigates error in RMS von Mises stress and its relationship to the error in acceleration for random vibration analysis. First, a theoretical development of stress-acceleration error is introduced for a simplified problem based on modal stress analysis. Using results from the example as a basis, a similar error relationship is determined for random vibration problems. Finite element analyses of test structures subject to an input acceleration auto-spectral density are performed and results from parametric studies are used to determine error. For a given error in acceleration, a relationship to the error in RMS von Mises stress is established. The resulting relation is used to calculate a bound on the RMS von Mises stress based on the computed accelerations. This error bound is useful in vibration analysis, especially where uncertainty and variability must be thoroughly considered.
THE INFLUENCE OF EARLY LITERACY CHARACTERISTICS AND SES ON THE LITERACY ACHIEVEMENT OF STUDENTS WHO SPEAK NON-DOMINANT LANGUAGES IN INDONESIA

Across the world, children from non-dominant language speaking families are not performing as well as their peers who speak a dominant language when they enter school. The current study examines the case of Indonesia, investigating the influence of language background status, early literacy characteristics, and socioeconomic status on literacy achievement in Indonesia. Drawing from the PIRLS 2011 dataset (N = 2,725), findings reveal that there is a significant association between each variable and literacy achievement, and that socioeconomic status explains literacy achievement most strongly among 4th grade students in Indonesia. Implications are discussed. DOI : doi.org/10.24071/ijiet.2019.030211
Abstract P2002: Loss of GSTM1 is Cardioprotective Against Ischemia-Reperfusion Injury

GSTM1 encodes the glutathione S-transferase μ-1 (GSTM1) enzyme that belongs to a superfamily of phase II antioxidant enzymes. In humans, a common deletion variant of the GSTM1 gene, the GSTM1(0) nu...
Как измерять мягкую силу в международных отношениях

В статье формулируются предложения автора по вопросам более эффективной оценки мягкой силы в международных отношениях, а также дифференциации ее количественных показателей по категориям, в наибольшей степени соответствующим стратегии количественного анализа. В центре внимания находится наиболее популярный и широко применяемый показатель – индекс мягкой силы “The Soft Power 30 Index”. По мнению автора, распространенные методы количественного анализа мягкой силы на основе наиболее популярных наборов данных не лишены недостатков. Проанализировав эти методы, автор предлагает собственный набор индикаторов, призванный сделать анализ мягкой силы более эффективным.
Resistance Mechanisms to Taxanes and PARP Inhibitors in Advanced Prostate Cancer.

Abstract The clinical landscape concerning advanced prostate cancer is rapidly changing and reaching beyond androgen deprivation therapy and androgen receptor-targeted therapies. Taxane chemotherapy is a critical tool in the management of advanced prostate cancer. Additionally, novel drug classes, such as PARP inhibitors, are being investigated. In spite of the tremendous progress, resistance to therapy remains as a major impediment to further improvement. Resistance mechanisms appear diverse and are not fully known or understood. This review will highlight recent advances in research regarding mechanisms of resistance to both taxanes (such as increased drug efflux capacity) and PARP inhibitors (such as reversion mutations, which restore DNA-repair proficiency). Understanding resistance to therapy promises to remove barriers blocking progress toward improved patient outcomes.
IMPACT OF A HISTORY OF ATRIAL FIBRILLATION ON THE MECHANISM OF MITRAL REGURGITATION, PROGNOSIS AND TREATMENT EFFECTS OF THE MITRACLIP: THE COAPT TRIAL

Atrial fibrillation (AF), mitral regurgitation (MR) and left ventricular ejection fraction (LVEF) have a complex interplay. We evaluated the role of AF in patients with heart failure (HF) and moderate-to-severe or severe MR enrolled in the COAPT trial and its impact on treatment with the MitraClip
Validation of algorithms to identify elective percutaneous coronary interventions in administrative databases.

Background Elective percutaneous coronary interventions (PCI) are difficult to discriminate from non-elective PCI in administrative data due to non-specific encounter codes, limiting the ability to track outcomes, ensure appropriate medical management, and/or perform research on patients who undergo elective PCI. The objective of this study was to assess the abilities of several algorithms to identify elective PCI procedures using administrative data containing diagnostic, utilization, and/or procedural codes. Methods and results For this retrospective study, administrative databases in an integrated healthcare delivery system were queried between 1/1/2015 and 6/31/2016 to identify patients who had an encounter for a PCI. Using clinical criteria, each encounter was classified via chart review as a valid PCI, then as elective or non-elective. Cases were tested against nine pre-determined algorithms. Performance statistics (sensitivity, specificity, positive predictive value, and negative predictive value) and associated 95% confidence intervals (CI) were calculated. Of 521 PCI encounters reviewed, 497 were valid PCI, 93 of which were elective. An algorithm that excluded emergency room visit events had the highest sensitivity (97.9%, 95%CI 92.5%-99.7%) while an algorithm that included events occurring within 90 days of a cardiologist visit and coronary angiogram or stress test had the highest positive predictive value (62.2%, 95%CI 50.8%-72.7%). Conclusions Without an encounter code specific for elective PCI, an algorithm excluding procedures associated with an emergency room visit had the highest sensitivity to identify elective PCI. This offers a reasonable approach to identify elective PCI from administrative data.
Prevalence of diabetic retinopathy in children and adolescents at an urban tertiary eye care center

Background Diabetic retinopathy (DR) is a serious complication that can progress to sight-threatening disease. The prevalence of DR in youth with diabetes has been reported to be 3.8% to 20%. Objective We aimed to evaluate the prevalence of DR among youth with diabetes at a large ophthalmologic referral center. Secondary goals were to determine the risk factors for DR and severity of disease. Methods Retrospective chart review of 343 patients with diabetes, Results The study included 343 patients, of which 293 had type 1 diabetes (T1D) and 50 had type 2 diabetes (T2D). Thirteen of 343 patients had DR, with an overall incidence of 3.8% (3.4% in T1D and 6% T2D). DR severity included nine with mild non-proliferative, three moderate non-proliferative, and one with proliferative DR. Patients with hemoglobin A1c (HbA1c) > 8% had a higher risk of DR (P = .049). In this cohort, none of the patients with an HbA1c Conclusions We found lower prevalence of DR in youth with diabetes than previously reported. The incidence of DR was higher among patients with T2D and occurred with a shorter duration of disease, as compared with T1D. While the incidence of DR in youth with T1D is low, with the increasing incidence of T2D in adolescents and early risk for DR, early screening must be emphasized.
Ministry of Fear: Fritz Lang’s De-suturing Operation

This chapter considers one of Fritz Lang’s less-heralded American films, showing how it employs idiosyncratic editing and staging strategies to imprint a seemingly conventional espionage/mystery thriller with Lang’s particular brand of self-reflexive paranoia. After reviewing much of the extant academic criticism of the film and providing a brief summary of the film’s production history, this chapter presents analyses of staging, framing and editing strategies in individual scenes, identifying stylistic and formal motifs that work to convey an ongoing sense that the action is constantly being observed by some unknown and unseen off-screen presence. It then relates Lang’s filmmaking choices in these instances to theories of cinematic “suturing” and proposes that the film’s dominant strategy may be seen as deliberately disrupting the system of the suture.
Enhancing the Lateral Orbital "C-Angle" With Calcium Hydroxylapatite: An Anatomic and Clinical Study.

BACKGROUND Deliberate injection of specific facial subunits may improve aesthetic outcomes in facial rejuvenation. We contend that the lateral orbital area (LOA) is a key anatomic subunit in the perception of eye attractiveness, with a C-shaped distribution of fat contributing to the formation of a distinct angle in the lateral orbit. OBJECTIVES The aim of this study was to describe the anatomy of the LOA that constitutes the C-shaped angle and to investigate the safety and cosmetic outcomes of nonsurgical enhancement of that area with calcium hydroxylapatite (CaHA). METHODS Four injected fresh-frozen cadaver heads were dissected. Twenty patients were enrolled in a prospective clinical study. Participants were seen on the day of injection, and at 2 weeks and 3 months postinjection. Two-dimensional and 3D photographs were analyzed to quantify the volumetric changes between pretreatment and postinjection time points. Secondary outcomes included Global Aesthetic Improvement Scale score and subject satisfaction at 3 months. RESULTS Cadaver dissections revealed distinct fat compartments and a zone of adhesion forming the C-shaped area around the lateral orbit. In the clinical study, a mean of 1.88 mL of CaHA was injected into each lateral periorbital region. There was 97% and 76% volume retention at 2 weeks and 3 months, respectively, with 70% of patients being "very satisfied" at 3 months. The average Global Aesthetic Improvement Scale rating at 3 months was 3.95. There were no complications. CONCLUSIONS The LOA is a distinct facial subunit that can be enhanced safely by CaHA injection with good cosmetic outcomes. Focusing on the C-angle can improve periorbital aesthetics. LEVEL OF EVIDENCE: 4
Post COVID-19 syndrome associated with orthostatic cerebral hypoperfusion syndrome, small fiber neuropathy and benefit of immunotherapy: a case report

Coronavirus disease (COVID-19) is a novel highly contagious infectious disease caused by the coronavirus SARS-CoV2. The virus affects the human respiratory and other systems, and presents mostly as acute respiratory syndrome with fever, fatigue, dry cough, myalgia and dyspnea. The clinical manifestations vary from no symptoms to multiple organ failure. Majority of patients fully recover. Several postinfectious presumably autoimmune complications of COVID-19 affecting the brain or peripheral large nerve fibers have been reported. This report describes a post COVID-19 patient who developed chronic fatigue, orthostatic dizziness and brain fog consistent with orthostatic hypoperfusion syndrome (OCHOS), a form of orthostatic intolerance, and painful small fiber neuropathy (SFN). Initially, the patient was diagnosed with. OCHOS (detected by the tilt test with transcranial Doppler monitoring) and SFN (confirmed by skin biopsy), and both OCHOS/SFN were attributed to Post Treatment Lyme Disease Syndrome of presumed autoimmune etiology. Patient recovered on symptomatic therapy. COVID-19 triggered exacerbation of OCHOS/SFN responded to immunotherapy with intravenous immunoglobulins. This case suggests that post COVID-19 syndrome may present as an autoimmune OCHOS/SFN and that early immunotherapy may be effective. Further studies are necessary to confirm the link between OCHOS/SFN and COVID-19 disease as well as to confirm the benefit of immunotherapy.
The Biochemistry of Memory

It has now been some thirteen years since I first started working with planarians. Sometimes when I stop and look back at this worm’s dozen of years, I wonder if I should not have told Bob Thompson to go have his head examined when he suggested back in 1953 that we see if we could not condition a flatworm. But one never has the choice of living one’s life over again in a different fashion, and I am not really sure I would change the basic pattern anyhow. For I have learned a great deal of psychology from working with the worms; indeed I have probably learned more about the behavior of that strange laboratory species called Homo scientificus than I had any desire to learn. If I could change things, I would not give up the worms, and I would not give up any of the experiments I have done (although many could have been better performed), but I do believe that those of us early in the field made some classic mistakes in the fine art of public relations. We were, in our green and callow days, pretty naive about the sort of reactions we should elicit from our colleagues. Instead of glossing over the possible significance of our findings, we stupidly said out loud, for everyone to hear, that we had found some pretty intriguing things in the laboratory.
Lateralized alpha activity and slow potential shifts over visual cortex track the time course of both endogenous and exogenous orienting of attention.

Spatial attention can be oriented endogenously, based on current task goals, or exogenously, triggered by salient events in the environment. Based upon literature demonstrating differences in the time course and neural substrates of each type of orienting, these two attention systems are often treated as fundamentally distinct. However, recent studies suggest that rhythmic neural activity in the alpha band (8-13Hz) and slow waves in the event-related potential (ERP) may emerge over parietal-occipital cortex following both endogenous and exogenous attention cues. To assess whether these neural changes index common processes of spatial attention, we conducted two within-subject experiments varying the two main dimensions over which endogenous and exogenous attention tasks typically differ: cue informativity (spatially predictive vs. non-predictive) and cue format (centrally vs. peripherally presented). This task design allowed us to tease apart neural changes related to top-down goals and those driven by the reflexive orienting of spatial attention, and examine their interactions in a novel hybrid cross-modal attention task. Our data demonstrate that both central and peripheral cues elicit lateralized ERPs over parietal-occipital cortex, though at different points in time, consistent with these ERPs reflecting the orienting of spatial attention. Lateralized alpha activity was also present across all tasks, emerging rapidly for peripheral cues and sustaining longer for spatially informative cues. Overall, these data indicate that distinct slow-wave ERPs index the spatial orienting of endogenous and exogenous attention, while lateralized alpha activity represents a common signature of visual-cortical biasing in anticipation of potential targets across both types of attention.
The Orthodox Church of Ukraine (OCU) and the Ukrainian Greek-Catholic Church (UGCC): a meeting after the tomos

The author explores the relations between the Ukrainian Greek-Catholic Church (UGCC) and the Orthodox Church of Ukraine (OCU) after the latter received the tomos of autocephaly from the Ecumenical ...
Hollow vortex in a corner

Equilibrium solutions for hollow vortices in straining flow in a corner are obtained by solving a free-boundary problem. Conformal maps from a canonical doubly connected annular domain to the physical plane combining the Schottky–Klein prime function with an appropriate algebraic map lead to a problem similar to Pocklington's propagating hollow dipole. The result is a two-parameter family of solutions depending on the corner angle and on the non-dimensional ratio of strain to circulation.
Endovascular reperfusion outcomes in patients with a stroke and low ASPECTS is highly dependent on baseline infarct volumes.

Background Patients with large vessel occlusion stroke (LVOS) and a low Alberta Stroke Program Early CT Score (ASPECTS) are often not offered endovascular therapy (ET) as they are thought to have a poor prognosis. Objective To compare the outcomes of patients with low and high ASPECTS undergoing ET based on baseline infarct volumes. Methods Review of a prospectively collected endovascular database at a tertiary care center between September 2010 and March 2020. All patients with anterior circulation LVOS and interpretable baseline CT perfusion (CTP) were included. Subjects were divided into groups with low ASPECTS (0–5) and high ASPECTS (6-10) and subsequently into limited and large CTP-core volumes (cerebral blood flow 30% >70 cc). The primary outcome measure was the difference in rates of 90-day good outcome as defined by a modified Rankin Scale (mRS) score of 0 to 2 across groups. Results 1248 patients fit the inclusion criteria. 125 patients had low ASPECTS, of whom 16 (12.8%) had a large core (LC), whereas 1123 patients presented with high ASPECTS, including 29 (2.6%) patients with a LC. In the category with a low ASPECTS, there was a trend towards lower rates of functional independence (90-day modified Rankin Scale (mRS) score 0-2) in the LC group (18.8% vs 38.9%, p=0.12), which became significant after adjusting for potential confounders in multivariable analysis (aOR=0.12, 95% CI 0.016 to 0.912, p=0.04). Likewise, LC was associated with significantly lower rates of functional independence (31% vs 51.9%, p=0.03; aOR=0.293, 95% CI 0.095 to 0.909, p=0.04) among patients with high ASPECTS. Conclusions Outcomes may vary significantly in the same ASPECTS category depending on infarct volume. Patients with ASPECTS ≤5 but baseline infarct volumes ≤70 cc may achieve independence in nearly 40% of the cases and thus should not be excluded from treatment.
Intelligent fault diagnosis for dynamic systems via extended state observer and soft computing

Abstract This chapter aims to address the common model-based fault diagnosis difficulties encountered in industries today. In other words, the plant model is usually uncertain, which leads to the model-based fault diagnosis techniques not working well. Furthermore, most fault diagnosis techniques assume that only the same type of fault, such as a process fault, occurs at the same time. This study uses extended state observer to detect faults without exact knowledge of the plant model, and a fuzzy inference system to help in fault isolation and fault identification. Considering that some faults are incipient in nature, trained neural networks were employed to help identify faults and determine the degree of fault in real time by means of inputs-to-outputs mapping. This chapter first presents fault diagnosis techniques by means of extended state observer, followed by investigating the complexity of fault isolation due to simultaneous faults of different types. A strongly coupled three-tank dynamic system—MIMO (a typical multiple-input, multiple-output system)—is given as a case study to illustrate the effectiveness of the presented techniques by means of computer simulation. As a result, this study demonstrates how faults can be detected with an uncertain plant model and how soft computing can make fault isolation and identification more reliable.
Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State

Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of cellular functions and diseases. During the reaction with peroxides (e.g., H2O2), the typical 2-Cys Prxs change oligomeric structure between higher order (do)decamers and disulfide-linked dimers, with the hyperoxidized inactive state (-SO2H) favoring the multimeric structure of the reduced enzyme. Here, we present a study on the structural requirements for the repair of hyperoxidized 2-Cys Prxs by human sulfiredoxin (Srx) and the relative efficacy of physiological reductants hydrogen sulfide (H2S) and glutathione (GSH) in this reaction. The crystal structure of the toroidal Prx1-Srx complex shows an extended active site interface. The loss of this interface within engineered Prx2 and Prx3 dimers yielded variants more resistant to hyperoxidation and repair by Srx. Finally, we reveal for the first time Prx isoform-dependent use of and potential cooperation between GSH and H2S in supporting Srx activity.
Impact of language preference and health literacy on health information-seeking experiences among a low-income, multilingual cohort.

Abstract Objective We examined the impact of language preference and health literacy on health information-seeking experiences in a multilingual, low-income cohort. Methods We administered a modified Health Information National Trends Survey in English, Spanish, and Chinese to a sample of San Francisco city/county residents. Using multivariable logistic regression analyses, we assessed how language and health literacy impact health information-seeking experiences (confidence, effort, frustration, quality concerns, and difficulty understanding information), adjusting for age, gender, race/ethnicity, education, usual place of care, health status, information-seeking behaviors, and smartphone ownership. Results Of 1000 participants (487 English-speaking, 256 Spanish-speaking, 257 Chinese-speaking), 820 (82%) reported at least one negative health information-seeking experience. Chinese-language was associated with frustration (aOR = 2.56; 1.12–5.86). Difficulty understanding information was more likely in Spanish-language respondents (aOR = 3.58; 1.25–10.24). Participants with limited health literacy reported more effort (aOR = 1.97; 1.22–3.17), frustration (aOR = 2.09; 1.28–3.43), concern about quality (aOR = 2.72; 1.60–4.61), and difficulty understanding information (aOR = 2.53; 1.58–4.05). Language and literacy impacted confidence only in the interaction term between Chinese-speakers and health literacy. Conclusion We found that negative health information-seeking experiences were common in non-English speaking populations those with limited health literacy. Practice implications Health communication efforts should consider both language preference and health literacy to ensure accessibility for all patients.
THE ANATOMY OF DIGITAL CLOUT(CHASING): BLACK AESTHETICS, ONLINE VISIBILITY AND RELATIONAL LABOR AMONG DIY HIP-HOP MUSICIANS ON CHICAGO’S SOUTH SIDE

Prior literature has suggested that it is through popular music that the social, professional and technological aspirations of Black youth often come together. Nowhere is this more evident than in the context of Hip-Hop music, where Black youth inventiveness with digital tools is celebrated and valued far more than any other genre of media entertainment. Though many scholars have theorized on the centrality of authenticity and masculinity to the communication of Hip-Hop artists in digital spaces, little academic work has paid very little attention to artist perspective of how this relational labor and visibility strategy helps them cultivate viable careers as influencers. Using interviews with artists, artist managers and independent label executives, I detail the career potentials for Hip-Hop artists engaging in social media self-branding strategies. I explore the content and character of their work on social media toward acquiring “clout”- a digital form of influence rooted in Hip-Hop that allows marginalized youth to leverage digital tools in build social status, maintain authenticity, cultivate connections with fans, connect to friends and other cultural producers. In this study, I detail examples of three relational strategies that our respondents utilized to acquire “digital clout:” a) Corralling b) Capping and, c) Co-Signing. To conclude, I argue Chicago’s Hip-Hop scene provides an example of why formal institutions need to rethink how race, class, gender and geography influence the digital practices of young people and how their practices add significantly to the understanding of the cultural and communicative diversity arising from globalizing social media.
Community health practicum with an oncology nursing focus.

Abstract A Community Health Practicum in Oncology Nursing for senior nursing students in a baccalaureate program is described. The practicum was designed to meet two objectives in the undergraduate curriculum: (1) to give students experience in the care of patients and families in the community by using cancer as a model of a life‐threatening disease requiring acute and chronic care, rehabilitation, etc. and (2) to provide knowledge about cancer care and prevention and give an opportunity for students to participate in a small‐scale cancer prevention project. Patient and family reactions to care provided by students were evaluated with a semi‐structured telephone interview. Evaluations of the students’ clinical performances and cancer prevention projects were made by instructor observation. Pre/post‐tests given to those being taught during the projects provided additional evaluations of the students’ projects. Evaluation of the students’ reactions to the learning experience was made by their responses to ...
Effect of a Sonographically Diffusely Enlarged Uterus Without Distinct Uterine Masses on the Outcome of In Vitro Fertilization–Embryo Transfer

Purpose: Our objective was to study the effect of a sonographically diffusely enlarged uterus without distinct uterine masses on the outcome of in vitro fertilization–embryo transfer (IVF-ET). Methods: Nineteen primary infertility patients undergoing IVF-ET who had a sonographically diffusely enlarged uterus without distinct uterine masses were enrolled. An age-controlled group of 144 primary infertility patients undergoing IVF-ET with a normal uterus and no history of uterine surgery was included. Results: The age, day 3 follicle stimulating hormone, antral follicle count, ovarian response, endometrial thickness, number of retrieved and fertilized oocytes, number of transferred embryos, clinical pregnancy rate, and total delivery rate were not statistically different between the two groups (P > 0.05). Patients with a sonographically diffused enlarged uterus without distinct uterine masses had a higher spontaneous abortion rate (66.7%) than controls (P < 0.04; odds ratio = 7.5;95% confidence interval, 1.16–48.56). Conclusions: A high spontaneous abortion rate was found in patients with a sonographically diffusely enlarged uterus without distinct uterine masses undergoing IVF-ET. Enhanced luteal support was required.