cssi/SciSciGPT-SciSciNet huggingface dataset:
Classification of T-cell and NK-cell neoplasms based on the REAL classification

Mature or peripheral T-cell lymphomas are uncommon, accounting for only 10%-15% of all non-Hodgkin's lymphomas. The classification of these neoplasms has been controversial. In contrast to B-cell lymphomas, cytologic grade has not been very useful in predicting the clinical course. This finding may result from the generally aggressive clinical course associated with T-cell lymphomas. Prior studies have suggested that stage of disease may be more important than cytologic subtype. Clinical presentation is very important in the classification of T-cell malignancies. For T-cell lymphomas, cytologic features alone are not sufficient to distinguish among disease entities. For example, adult T-cell leukemia/lymphoma (ATLL) often cannot be distinguished morphologically from HTLV-1-negative T-cell lymphomas. Most extranodal T-cell lymphomas appear to be derived from cytotoxic T cells, which express perforin, TIA-I, and granzyme B. Three broad groups of T-cell malignancies can be identified: (1) leukemic or systemic disease; (2) nodal disease; (3) extranodal disease. Anaplastic large-cell lymphoma (ALCL) is probably the single most common subtype of T-cell lymphoma. Classical ALCL should be distinguished from primary cutaneous ALCL (CD30+ lymphoproliferative disease of the skin), which is a distinct disease entity.
Provenance-Aware Sensor Data Storage

Sensor network data has both historical and realtime value. Making historical sensor data useful, in particular, requires storage, naming, and indexing. Sensor data presents new challenges in these areas. Such data is location-specific but also distributed; it is collected in a particular physical location and may be most useful there, but it has additional value when combined with other sensor data collections in a larger distributed system. Thus, arranging location-sensitive peer-to-peer storage is one challenge. Sensor data sets do not have obvious names, so naming them in a globally useful fashion is another challenge. The last challenge arises from the need to index these sensor data sets to make them searchable. The key to sensor data identity is provenance, the full history or lineage of the data. We show how provenance addresses the naming and indexing issues and then present a research agenda for constructing distributed, indexed repositories of sensor data.
How organizational commitment of critical care nurses influence their overall job satisfaction

Background: J ob satisfaction is an important component of nurses’ lives that can have an effect on patient satisfaction and safety, productivity and performance, quality of care, retention, turnover, and commitment to the organization and the profession. Job dissatisfaction affects nurses’ commitment to the organization. Methods : This non-experimental, quantitative study was conducted of critical care nurses who practice in a non-profit healthcare organization in New York City. The study consisted of a purposive sample of 204 critical care nurses who were employed in various critical-care units such as medical intensive care units (MICU), cardiothoracic intensive care unit CTICU) Cardiac care unit (CCU), neuroscience intensive care unit, burn intensive care unit, and surgical intensive care unit( SICU). Two pre- existing, validated instruments (Organizational Commitment Questionnaire and Job in General scale) was used to gather data for the current study. Statistical analysis of data was performed. Findings: There is a significant correlation between Organizational commitment and Job Satisfaction ( r = .66, p = .00). The regression model examining the association between gender, age, years as an RN, years with current employer, highest educational degree and job satisfaction (the dependent variable) was not statistically significant ( F (5, 87) = .605, p = .69). The ANOVAs for the impact of ethnicity, specialty certification, specialty area, title, shift, and employment status were not statistically significant ( p > .05). Conclusion: The relationship between critical care nurses’ organizational commitment and job satisfaction reaffirms the importance of nurse leaders routinely monitoring nurses’ satisfaction and implementing strategies that address the dimensions of job satisfaction.
Stability and robustness analysis tools for marine robot localization and SLAM applications

Our aim is to explore the fundamental stability issues of a robotic vehicle carrying out localization, mapping, and feedback control in a perturbation-filled environment. Motivated by the application of an ocean vehicle performing an autonomous ship hull inspection, our planar vehicle model performs localization using point features from a given map. Cases in which the agent must update the map are also considered. The stability of the controller and estimator duo is investigated using a pair of theorems requiring boundedness and convergence of the transition matrix Euclidean norm. These theorems yield a stability test for the feedback controller. Perturbations are then considered using a theorem on the convergence on the perturbed system transition matrix, yielding a robustness test for the estimator. Together, these tests form a set of tools which can be used in planning and evaluating the robustness of marine vehicle survey trajectories, which is demonstrated through experiment.
Design of a general purpose meta-assembler for parallel processor environment in ISPS

This paper discusses the design of a general-purpose meta- assembler for both single processor and parallel processor environments to be used as a software tool to improve upon the capability of the ISPS (Instruction Set Processor Specification) simulator. Currently, it is not feasible to simulate multi-microprocessor systems capable of performing parallel processing tasks efficiently in the ISPS language. There remains the problem of running long benchmark programs that have to be written in the machine code of the particular architecture(s) under study. With this in mind run-time results of simulated benchmark programs will be reported for various configurations of parallel processing systems using the meta assembler. We introduce a general purpose assembler for ISPS which will generate the machine code for simulation files. This software package eliminates the inefficiency of writing and testing long benchmark programs in the machine code by providing the user with the capability of writing them in assembly language. This package provides for existing assembly languages and can allow the user to create assembly languages for other possible architecture designs. It is hoped that this software package will make ISPS a more complete and powerful hardware description language.
An Analysis of “Ban the Box” Policies through the Prism of Merton’s Theory of Unintended Consequences of Purposive Social Action

After decades of “tough on crime” policies, the number of ex-offenders in the USA has increased dramatically. Felony convictions limit ex-offenders’ opportunities in the labor market. In an effort ...
Application of a two-fluid theoretical plasma energy confinement scaling to current Tokamak reactor designs

A two-fluid theoretical model of heat transport in tokamaks is developed based on microinstabilities. A tau/sub E/ scaling of the form tau/sub E/=1.832a/sup 2.45/R/sup 0.59/q/sub a//sup -2.07/ X B/sub T//sup 0.91//sup 0.46/Z/sup -0.09/P/sub T//sup -0.55//sub {Kappa}//sup 0.55/ has been determined from this transport model. The theoretical tau/sub E/ scaling is used to determine the smallest size tokamak fusion reactor for two cases, ignition and Q=5 steady state. Parameters are in good agreement with Tokamak Ignition/Burns Experimental Reactor II designs based on empirical Kaye-Goldston tau/sub E/ scaling.
Project HOPE volunteers and the Navy Hospital Ship Mercy.

ABSTRACT This article describes, from the perspective of Project HOPE volunteers, the precedent-setting, military-civilian partnership in staffing the USNS Mercy as part of the rapid response of the United States to the overwhelming devastation and loss of life resulting from the tsunami off the coast of Indonesia. The article discusses the designation of Project HOPE as the nongovernmental organization to be the single source of volunteers for the USNS Mercy mission (providing ∼ 100 volunteers for each of two 30-day rotations), some issues facing Project HOPE and the contingent of volunteers in recruiting, orienting, training, and preparing for the mission, steps taken to make this a successful mission despite the ambiguity and uncertainties involved in arriving in the relief area 1 month after the disaster, and some recommendations for similar future missions. The Project HOPE volunteers quickly integrated with the cadre of Navy health professionals to deliver a broad range of high-quality care, includi...
Effects of surface-active agents on carbohydrate metabolism in yeast.

Summary1. The effects of several surface-active agents on carbohydrate metabolism have been studied. Fermentation, oxygen consumption, and the Pasteur Effect are affected by these agents. 2. With the exception that oxygen consumption is affected differently by various surfactants tested, all 4 agents show qualitative similarities in their effects on carbohydrate metabolism. Benzalkonium chloride showed greatest effect on aerobic CO2 production and the Pasteur Effect. 3. Several hexoses used as substrates showed the effect of benzalkonium ion to be non-specific in its action on metabolism of 3 hexose substrates. 4. Effects of the agents on oxygen consumption and effects of pH were discussed.
Reply to "Comment on `Theory of chemisorption on metallic surfaces: Role of intra-adsorbate Coulomb correlation and surface structure' "

Arguments to refute the preceding comments made by Brenig and Sch\"onhammer (BS) are presented. In particular we note that the BS interpretation of the adsorbate induced peak in ultraviolet photoelectron spectra is inconsistent with their theoretical results.
Synthesis of ascorbic acid in guinea pigs by an implanted dialysis bag containing L-gulonolactone oxidase.

Guinea pigs fed no ascorbic acid develop scurvy due to the inherited absence of the enzyme L-gulonolactone oxidase. However, by providing this enzyme together with its substrate L-gulonolactone, synthesis of the vitamin and prevention of scurvy are demonstrated in this species. Rat liver enzyme is placed in a dialysis bag which has been surgically implanted within the animals9 peritoneal cavities. Substrate is then injected into the penitoneum. Plasma concentrations of ascorbic acid are markedly increased in enzyme-treated animals compared to similar bovine albumin-treated control animals. Adrenal gland, liver, and other tissue concentrations of the vitamin are also significantly elevated. Prolonged time of survival of enzyme-treated guinea pigs fed the ascorbic acid-deficient diet is shown. Enzyme placed within the dialysis bags does not appear to be antigenic, whereas unprotected enzyme is clearly antigenic.
Controversies in the Management of Intracranial Germinomas

Intracranial germinomas are uncommon tumors. In the past, patients have traditionally been diagnosed with a trial of focal radiotherapy without biopsy. If the tumor was radiosensitive, it was presumed to be a germinoma.
United states government health programs for children.

Myriad maternal and child health programs are scattered throughout different cabinet departments, agencies, and bureaus in the government. A summary of 29 of the more important federal health programs which have direct applicability to the practicing pediatrician and his patients is presented.
Repeated Thrombosis After Synthetic Cannabinoid Use.

Abstract Background Synthetic cannabinoids are swiftly gaining popularity and have earned a reputation of being relatively safer than other illicit drugs. However, there is a growing body of literature associating thromboembolic events with their use. Case Report A 32-year-old woman presented on four separate occasions with a new thromboemoblic event after smoking synthetic cannabinoids. She had no medical history, and over the span of 9 months she developed two kidney infarcts, pulmonary emboli, and an ischemic stroke. Each of these events occurred within 24 hours of smoking synthetic cannabinoids. During periods of abstinence, she remained free of thrombotic events. Why Should an Emergency Physician Be Aware of This? This report shows that an association between thrombosis and the use of synthetic cannabinoids is reproducible and involves both venous and arterial thrombosis, suggesting activation of coagulation or inflammatory pathways. As the popularity of this drug continues to grow, we can expect to see a growing number of these cases. Synthetic cannabinoid use should be included in the differential diagnosis of young patients with no risk factors who present with venous or arterial thrombosis.
Conceiving the Indian Buddhist Patriarchs in China

If Buddhist studies in the 1990s was the age of the imaginaire, the first decades of the twenty-first century may be remembered as age of the “repertoire.” Our collective fascination with the “repe...
Safety-oriented pavement performance thresholds: Accounting for unobserved heterogeneity in a multi-objective optimization and goal programming approach

Abstract The cornerstone of transportation infrastructure asset management is managing the physical infrastructure, with pavement preservation being one of the most critical and costly assets. Preserving pavements in an appropriate manner extends their service life, and most importantly improves motorists’ safety and satisfaction while saving public tax dollars. To that end, this paper presents a methodology to estimate pavement performance thresholds that are cost-effective and safe for users. Using data from Indiana, the relationships of the three criteria, i.e., safety (accident rates), normalized treatment cost and pavement service life, with the pavement performance (roughness, rutting, overall rating, and surface deflection), road geometry, traffic characteristics and climate - are investigated and estimated. These relationships are utilized in a multi-objective optimization and goal-programming scheme to identify performance threshold values that trigger preservation treatments. These analytically determined threshold values are found to be comparable to historical thresholds and thresholds derived from experts’ and users’ opinions.
Giant Spontaneous Greater Saphenous Vein Aneurysm

Venous aneurysm, a rare venous anomaly, poses increased risk of distal thromboembolic event. Superficial venous aneurysm, such as greater saphenous vein aneurysm, is an uncommon subset with nonspecific symptoms and often a delay in diagnosis. Symptomatic patients or patients with a thromboembolic event may benefit from surgical intervention with low morbidity. This case report describes an isolated spontaneous greater saphenous vein aneurysm which was successfully ligated and resected for symptomatic relief and prevention of distal thromboembolism.
Framing the President: the Dominant Ideology – Comprehensive Repertoire of News Frames // Enquadrando o Presidente: a ideologia dominante – repertório compreensivo dos quadros midiáticos

The theory of a dominant ideology underlying the news remains unacceptable for the commercial press and undermines its legitimacy. For social constructionists, no description or categorization is neutral. If all reporting has a point of view and the news inherently evaluates and frames events, the heuristic task is to demonstrate the existence of a single inventory of repeatedly used and shared “stock phrases” that consistently interpret “objective” events. Our case study examines coverage of U.S. President Bill Clinton in his first two years. Despite the wide number of events occurring and the large number of articles reviewed (N=513), the Clinton presidency was consistently portrayed using a finite and relatively small number of frames. We provide preliminary evidence of an industry-wide inventory of frames used by news workers over time and in a range of newsroom settings.
Rapid drawdown of Antarctica's Wordie Ice Shelf glaciers in response to ENSO/Southern Annular Mode-driven warming in the Southern Ocean

Abstract Here we investigate the largest acceleration in ice flow across all of Antarctica between ∼2008 InSAR and 2014 Landsat velocity mappings. This occurred in glaciers that used to feed into the Wordie Ice Shelf on the west Antarctic Peninsula, which rapidly disintegrated in ∼1989. Between 2008 and 2014, these glaciers experienced at least a threefold increase in surface elevation drawdown relative to the 2002–2008 time period. After ∼20 yrs of relative stability, it is unlikely that the ice shelf collapse played a role in the large response. Instead, we find that the rapid acceleration and surface drawdown is linked to enhanced melting at the ice-ocean boundary, attributable to changes in winds driven by global atmospheric circulation patterns, namely the El Nino–Southern Oscillation (ENSO) and Southern Annular Mode (SAM), linking changes in grounded ice to atmospheric-driven ocean warming.
Higher power generation from torsion-dominant mode in a zigzag shaped two-dimensional energy harvester

Abstract Torsion- and bending-dominant modes of a zigzag-shaped piezoelectric vibrational energy harvester were compared in terms of power generation using experimental and numerical methods. Output power measurements from 25 discrete mass loading configurations led to three major observations: (1) a torsion-dominant mode can produce a higher level of power compared to a bending-dominant mode, (2) generated power in the torsion-dominant mode displays a V-shape curve under certain mass loading, rather than continually increasing as a function of mass, and (3) generated power in the bending-dominant mode is largely independent of mass. These observations differ from the conventional wisdom that bending modes are better for energy harvesting and that power increases as a function of added mass. Numerical analysis is used to validate the variation of generated power and is found to be in agreement with the experimental results. Analysis of the displacement and gradation angle of equi-displacement measurements of the beam are used to provide understanding of the influence of dynamics of the energy harvester on power generation.
Estimating the Integrated Information Measure Phi from High-Density Electroencephalography during States of Consciousness in Humans

The integrated information theory (IIT) proposes a quantitative measure, denoted as Φ, of the amount of integrated information in a physical system, which is postulated to have an identity relationship with consciousness. IIT predicts that the value of Φ estimated from brain activities represents the level of consciousness across phylogeny and functional states. Practical limitations, such as the explosive computational demands required to estimate Φ for real systems, have hindered its application to the brain and raised questions about the utility of IIT in general. To achieve practical relevance for studying the human brain, it will be beneficial to establish the reliable estimation of Φ from multichannel electroencephalogram (EEG) and define the relationship of Φ to EEG properties conventionally used to define states of consciousness. In this study, we introduce a practical method to estimate Φ from high-density (128-channel) EEG and determine the contribution of each channel to Φ. We examine the correlation of power, frequency, functional connectivity, and modularity of EEG with regional Φ in various states of consciousness as modulated by diverse anesthetics. We find that our approximation of Φ alone is insufficient to discriminate certain states of anesthesia. However, a multi-dimensional parameter space extended by four parameters related to Φ and EEG connectivity is able to differentiate all states of consciousness. The association of Φ with EEG connectivity during clinically defined anesthetic states represents a new practical approach to the application of IIT, which may be used to characterize various physiological (sleep), pharmacological (anesthesia), and pathological (coma) states of consciousness in the human brain.
Molecular determination of claudin-15 organization and channel selectivity.

Tight junctions are macromolecular structures that traverse the space between adjacent cells in epithelia and endothelia. Members of the claudin family are known to determine tight junction permeability in a charge- and size-selective manner. Here, we use molecular dynamics simulations to build and refine an atomic model of claudin-15 channels and study its transport properties. Our simulations indicate that claudin-15 forms well-defined channels for ions and molecules and otherwise “seals” the paracellular space through hydrophobic interactions. Ionic currents, calculated from simulation trajectories of wild-type as well as mutant channels, reflect in vitro measurements. The simulations suggest that the selectivity filter is formed by a cage of four aspartic acid residues (D55), contributed by four claudin-15 molecules, which creates a negative electrostatic potential to favor cation flux over anion flux. Charge reversal or charge ablation mutations of D55 significantly reduce cation permeability in silico and in vitro, whereas mutations of other negatively charged pore amino acid residues have a significantly smaller impact on channel permeability and selectivity. The simulations also indicate that water and small ions can pass through the channel, but larger cations, such as tetramethylammonium, do not traverse the pore. Thus, our model provides an atomic view of claudin channels, their transport function, and a potential three-dimensional organization of its selectivity filter.
TZSlicer: Security-aware dynamic program slicing for hardware isolation

To address security issues related to information leakage, microprocessor designers and manufacturers such as ARM and Intel have introduced hardware isolation-based technologies to support secure software execution. However, utilizing such technologies often requires significant efforts to design new applications or refactor existing applications to adhere to the usage protocols. Developers also need to clearly distinguish code sections that can manipulate sensitive data and relocate them to the secure execution environment. These processes can be laborious and error-prone, since over-protection can result in poor application performance and high resource usage, and under-protection may cause exploitable security vulnerabilities. In this paper, we introduce TZSlicer, a framework to automatically identify code that must be protected based on a sensitive variable list provided by developers. TZSlicer automatically identifies code sections that can process sensitive data, extracts those sections from the original program, and creates harness in the original and extracted code sections so that they can interface with each other. We develop a prototype of TZSlicer to support slicing of C programs at function, code block, and code line levels. Also, we identify optimization opportunities to improve the context switching overhead of TZSlicer via applying loop unrolling and variable renaming. We evaluate TZSlicer using seven real-world programs, and the evaluation results indicate that TZSlicer is effective in protecting sensitive data without incurring significant runtime and resource usage overheads.
EXACT STRESS STATES AND VELOCITY FIELDS IN BICRYSTALS AT THE YIELD POINT IN CHANNEL DIE COMPRESSION

The archive publications in plasticity of Professor Paul M. Naghdi span forty years, and include two major survey articles [1, 2] giving valuable perspectives on the field at their respective times (1960 and 1990). Recently he has turned some of his attention to the topic of crystal plasticity (see [2], Section 8, for example). An analytical investigation of a special problem within that subfield is the subject of this paper.
Beyond words: What can help first year medical students practice effective empathic communication?

Abstract Objective To gain insight into first year medical students’ experiences of practicing empathic communication and how patients that train students perceive such communication, in order to inform early communication skills training. Methods Our study consisted of four focus groups, two of year one students who completed a first semester clinical skills course, one of standardized patients, and one of volunteer outpatients. Focus group transcripts were independently coded and iteratively reviewed to identify major themes. Course evaluation data was collected and analyzed. Results Themes from student focus groups described significant challenges in striving to convey empathy: coping with anxiety due to multitasking, “buying-in” to learning empathy, and managing vulnerability when engaging emotionally. Patients appreciated students’ expression of vulnerability and nonverbal communication. Conclusion First year medical students encounter challenges in learning empathic communication, and patients may perceive empathy from students in ways other than verbal responses. Early communications curricula should focus on assisting students with anxiety of multi-tasking, sense of vulnerability, buy-in to communications training, and the importance of non-verbal communication. Practice implications A deliberate focus on empathetic responsiveness, especially non-verbal, might lessen anxiety, improve attentional switching, and build confidence in managing vulnerability for early medical students learning communication skills.
Management of Peridevice Leak Following Left Atrial Appendage Occlusion

Residual leaks are not uncommon following percutaneous left atrial appendage occlusion (LAAO). There are currently no guidelines on the optimal management of these leaks, but life-long anticoagulation has been recommended in large persistent leaks. Percutaneous closure of peridevice leak is a viable
A Schrödinger Operator with \(\delta \prime \)-Interaction

The number of negative eigenvalues of a Schrodinger operator with point \(\delta \prime \)-interaction and with a \(\delta \prime \)-interaction on a Cantor set are found.
Associations between frequency of food shopping at different food sources and fruit and vegetable intake among rural residents in upstate New York, USA.

OBJECTIVE To examine the frequency of shopping at different food sources and the associations between shopping at different food sources and fruit and vegetable (FV) intake among upstate New York rural residents. DESIGN Cross-sectional study. Descriptive statistics and linear mixed models were used. SETTING Eighty-two rural communities in upstate New York, USA. PARTICIPANTS Adults (n 465; 82·3 % female, mean age 51·5 years, mean BMI 31·7 kg/m2). RESULTS Within one's community, the majority of participants reported often going to supermarkets (73·1 %). Many participants sometimes or occasionally shopped at superstores (48·0 %), convenience stores (57·9 %), small grocery stores or local markets (57·2 %), farmers' markets or FV stores (66·6 %), dollar stores (51·5 %), pharmacies (46·0 %), or farm stands or community-supported agriculture (56·8 %). Most participants had never utilized food banks or food pantries (94·0 %), community gardens (92·7 %) or home food delivery (91·9 %). While frequent visits to farmers' markets or farm stands were associated with higher fruit intake (P < 0·001), frequent visits to food co-ops or food hubs were associated with lower fruit intake (P = 0·004). Frequent visits to convenience stores (P = 0·002) and dollar stores (P = 0·004) were associated with lower vegetable intake. When FV intakes were combined, frequent visits to farmers' markets or farm stands (P < 0·001) were associated with higher FV intake, and frequent visits to convenience stores (P = 0·005) were associated with lower FV intake. CONCLUSIONS Findings from the present study provide important insight for informing future food environment interventions related to helping rural residents consume adequate FV.
Applied digital library project management: Using decision tree analysis to clarify multipath problems

Purpose – This paper seeks to define and describe decision tree analysis as a method for decision making when there are multiple, linearly or hierarchically related decision points that must be considered when determining the optimum choices within a project. Design/methodology/approach – Using theory and example, the paper relates the use of decision tree analysis to the successful selection of decision points in complex, multistage digital library projects. Findings – Decision tree analysis is useful as a method for both determining the various courses of action within a project and visualizing these choices in an easily understood format. Decision tree analysis can help a team understand the relationships between issues in a project as well as the consequences of various courses of action. Originality/value – The paper fills a gap in the digital library project management literature by providing an overview of a tool used in operational research that helps identify an optimal course of action within a complex system of interrelated decisions.
Perioperative Medication Management

The management of a patient’s home medication regimen around a surgical procedure is an essential component of perioperative medicine. Clinicians must consider which routine medications might cause harm versus which are essential to controlling the underlying medical condition(s) during the perioperative period. This chapter provides guidance for clinicians in this risk–benefit assessment while acknowledging that there is a general lack of outcome data about routine medication management in the perioperative setting.
Lesion Imaging and Target Detection in Complex Heterogeneous Media: Application to Lung Nodules

Ultrasound imaging in strongly heterogeneous media is challenging due to the aberrations caused by multiple scattering. The linearity between distance and time is lost making echolocation-based imaging elusive. In this study, we present a method for the imaging of anechoic lesions and targets in highly scattering media taking advantage of ultrasound multiple scattering. First, in silico, heterogeneous media are simulated with 10% area fraction of plastic scatterers in water. Circular lesion (areas with no scatterers) with diameter 8mm are placed at a depth of 10mm. Experimentally, a petroleum jelly lesion is placed in a sponge partially saturated with water, and in a pig lung ex vivo. Inter-elements Response Matrix are acquired using a tranducer array. The backscattered intensity is calculated and split into its coherent and incoherent parts. From the incoherent intensity, a diffusion map is generated and combined with a depression detection algorithm to predict the presence, location and size of the lesions.
Pregnancy outcomes after frozen-thawed single euploid blastocyst transfer following IVF cycles using GNRH agonist or HCG trigger for final oocyte maturation

To assess whether GnRH agonist trigger impacts the implantation potential of euploid embryos. Retrospective cohort study done at an academic IVF center evaluating frozen-thawed embryo transfer (FET) cycles in which single-euploid blastocysts were transferred between 2014 and 2019. All embryos were generated in an IVF cycle which used GnRHa or hCG trigger and then were transferred in a programmed or natural FET cycle. Only the first FET cycle was included for each patient. Primary outcome was ongoing pregnancy rate or live birth rate (OPR/LBR). Secondary outcomes were implantation rate (IR), clinical pregnancy rate (CPR), clinical loss rate (CLR), and multiple pregnancy rate (MPR). Logistic regression was performed to control for confounding variables. A p value of 35 years old). Our findings confirm that euploid embryos created after hCG or GnRHa trigger have the same potential for pregnancy.
Ki-67 Labeling Index in Pulmonary Carcinoid Tumors: Comparison Between Small Biopsy and Resection Using Tumor Tracing and Hot Spot Methods.

Context.— Pulmonary carcinoids are classified as typical or atypical by assessing necrosis and mitoses, which usually cannot be adequately assessed on small biopsies. Ki-67 is not currently used to...
Chemical Exposures, Health, and Environmental Justice in Communities Living on the Fenceline of Industry

Polluting industries are more likely to be located in low-income communities of color who also experience greater social stressors that may make them more vulnerable than others to the health impacts of toxic chemical exposures. We describe recent developments in assessing pollutant exposures and health threats posed by industrial facilities using or releasing synthetic chemicals to nearby communities in the U.S. More people are living near oil and gas development due to the expansion of unconventional extraction techniques as well as near industrial animal operations, both with suggestive evidence of increased exposure to hazardous pollutants and adverse health effects. Legacy contamination continues to adversely impact a new generation of residents in fenceline communities, with recent studies documenting exposures to toxic metals and poly- and perfluoroalkyl substances (PFASs). Researchers are also giving consideration to acute exposures resulting from inadvertent industrial chemical releases, including those resulting from extreme weather events linked to climate change. Natural experiments of industrial closures or cleanups provide compelling evidence that exposures from industry harm the health of nearby residents. New and legacy industries, coupled with climate change, present unique health risks to communities living near industry due to the release of toxic chemicals. Cumulative impacts from multiple stressors faced by environmental justice communities may amplify these adverse effects.
Leonardo Sciascia e la funzione sociale degli intellettuali

Leonardo Sciascia e la funzione sociale degli intellettuali collects the translations of three writings that have already appeared in English-speaking scientific journals - L'onore, il qualunquismo e l'essenzialismo ne L'antimonio di Sciascia, Sciascia e La scomparsa di Majorana and De L'Affaire Moro e della (ri)scrittura della storia - as well as an in-depth introduction that provides an overview of the author's research results on Sciascia - from which a much more conservative Sciascia than is commonly believed is revealed - as well as an analysis of Sciascia's poetics (centred on the public self-image of the "spoiler"). The essay ends with a concluding chapter where the last decade of Sciascia's career is examined (the period after L'Affaire Moro and the participation of the Sicilian writer in the Moro Commission) during which the author publishes various collections of essays - such as La strega e il capitano, 1912+1, Una storia semplice - and traces an essay on Telesio Interlandi, ideologue of the discriminatory legislation of 1938.Leonardo Sciascia e la funzione sociale degli intellettuali raccoglie traduzioni di tre scritti gia apparsi su riviste scientifiche anglofone – L'onore, il qualunquismo e l'essenzialismo ne L'antimonio di Sciascia, Sciascia e La scomparsa di Majorana e De L'Affaire Moro e della (ri)scrittura della storia – oltre ad una approfondita introduzione che fornisce una visione d'insieme dei risultati delle ricerche dell'autore su Sciascia – dai quali emana uno Sciascia molto piu conservatore di quanto comunemente si creda – nonche un'analisi della poetica sciasciana (imperniata sull'autoimmagine pubblica del "guastatore"). Chiude il saggio un capitolo conclusivo dove si esamina l'ultimo decennio della carriera di Sciascia (il periodo posteriore a L'Affaire Moro e la partecipazione dello scrittore siciliano alla Commissione Moro) durante il quale l'autore pubblica varie raccolte di saggi – come La strega e il capitano, 1912+1, Una storia semplice – e progetta un saggio su Telesio Interlandi, ideologo della legislazione discriminatoria del 1938.
Chromohalobacter salixigens uronate dehydrogenase: Directed evolution for improved thermal stability and mutant CsUDH-inc X-ray crystal structure

Abstract Chromohalobacter salixigens contains a uronate dehydrogenase termed CsUDH that can convert uronic acids to their corresponding C1,C6-dicarboxy aldaric acids, an important enzyme reaction applicable for biotechnological use of sugar acids. To increase the thermal stability of this enzyme for biotechnological processes, directed evolution using gene family shuffling was applied, and the hits selected from 2-tier screening of a shuffled gene family library contained in total 16 mutations, only some of which when examined individually appreciably increased thermal stability. Most mutations, while having minimal or no effect on thermal stability when tested in isolation, were found to exhibit synergy when combined; CsUDH-inc containing all 16 mutations had ΔK t0.5 +18 °C, such that kcat was unaffected by incubation for 1 h at ∼70 °C. X-ray crystal structure of CsUDH-inc showed tight packing of the mutated residue side-chains, and comparison of rescaled B-values showed no obvious differences between wild type and mutant structures. Activity of CsUDH-inc was severely depressed on glucuronic and galacturonic acids. Combining select combinations of only three mutations resulted in good or comparable activity on these uronic acids, while maintaining some improved thermostability with ΔK t0.5 ∼+ 10 °C, indicating potential to further thermally optimize CsUDH for hyperthermophilic reaction environments.
Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX

BCL-2 family proteins converge at the mitochondrial outer membrane to regulate apoptosis and maintain the critical balance between cellular life and death. This physiologic process is essential to organism homeostasis and relies on protein-protein and protein-lipid interactions among BCL-2 family proteins in the mitochondrial lipid environment. Here, we find that trans-2-hexadecenal (t-2-hex), previously implicated in regulating BAX-mediated apoptosis, does so by direct covalent reaction with C126, which is located on the surface of BAX at the junction of its α5/α6 core hydrophobic hairpin. The application of nuclear magnetic resonance spectroscopy, hydrogen-deuterium exchange mass spectrometry, specialized t-2-hex-containing liposomes, and BAX mutational studies in mitochondria and cells reveals structure-function insights into the mechanism by which covalent lipidation at the mitochondria sensitizes direct BAX activation. The functional role of BAX lipidation as a control point of mitochondrial apoptosis could provide a therapeutic strategy for BAX modulation by chemical modification of C126.
The Persistence of Indigenous Silver Production in Porco, Bolivia

Technological change has interested archaeologists since the inception of the field, but persistence – particularly in a broader context of social transformation – is also a phenomenon that demands explanation. This paper examines the persistence of Indigenous silver production in Porco, Bolivia from Inka times to the twenty-first century, arguing that rather than solely being the result of either passive traditionalism or active identity creation, it can be most fully understood in terms of the intersection of technological practice with a changing local political economy.
Can nutrient additions facilitate recovery of Pacific salmon

Multiple restoration actions have been implemented in response to declining salmon populations. Among these is the addition of salmon carcasses or artificial nutrients to mimic marine-derived nutri...
Persuasion, News Sharing, and Cascades on Social Networks

We study a model of online news dissemination on a Twitter-like social network. Given a news item and its credibility, agents with heterogeneous priors strategically decide whether to share the news with their followers. An agent shares the news, if the news can persuade her followers to take an action (such as voting) in line with the agent's perspectives. We describe the agent's decision making and the conditions that lead to sharing the news with followers, and characterize the size of news spread at the equilibrium of the news-sharing game. We further investigate the impact of the network connectivity, heterogeneity of prior perspectives, and news credibility on the set of the news that can trigger a sharing cascade. Finally, we identify the conditions under which the news with low credibility can spread wider than highly credible news. In particular, we show that when the network is highly-connected or the news is not a ``tail event'', a sharing cascade can occur even with news that is not credible.
Observed surface densities in globular clusters

This review of observations is oriented toward the problem of core collapse in globular clusters. After a brief discussion of methods of determining surface densities, recent results are cited which show that the central brightness peak seen in M15 also appears in several other clusters. The central peaks of brightness are interpreted as the result of core collapse, which theories have repeatedly predicted. If binaries stabilize the collapsed core, the cluster should follow a Henon model. In two of the three cases tested this model is a reasonable fit. Remaining theoretical questions are listed, as are observational needs.
DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain

Recently, the Dlx family of homeobox genes have been identified as candidates for regulating patterning and differentiation of the forebrain. We have made a polyclonal antiserum to the protein product of the Dlx-2 gene. Using this antiserum, we have characterized the spatial and temporal pattern of DLX-2 protein expression during murine development and in the adult mouse brain. These studies demonstrate that, like the mRNA from the Dlx-2 gene, DLX-2 protein is expressed in mouse embryonic forebrain, limbs, tail, genital tubercle, and branchial arches. Within the embryonic forebrain, DLX-2 protein is expressed within specific transverse and longitudinal domains. Analysis of expression within the wall of the forebrain shows that DLX-2 is expressed in proliferative regions including the ventricular and subventricular zones. DLX-2 is expressed in the same cells as MASH-1, a marker of relatively undifferentiated cells, but in a reciprocal fashion to MAP-2, a marker of terminal neuronal differentiation. A number of DLX-2-expressing cells, but not all, can be labeled with bromodeoxyuridine (BrdU). Using the patterns of DLX-2, MASH-1, MAP-2 expression, and bromodeoxyuridine incorporation, we identify four molecularly distinct populations of cells that may correspond to different stages of neuronal differentiation in the mouse basal forebrain, in which DLX-2 is expressed at the transition from proliferation to terminal differentiation.
Denoising Via Block Wiener Filtering in Wavelet Domain

In this paper we describe a new method for image denoising. We analyse statistical properties of the wavelet coefficients of natural images. It turns out that there is a strong local covariance structure introduced by the edges. We suggest a model for this covariance which allows us to estimate it from the noisy image. Then Wiener filter is employed in order to remove the noise.
Spherical-Homoscedastic Distributions: The Equivalency of Spherical and Normal Distributions in Classification

Many feature representations, as in genomics, describe directional data where all feature vectors share a common norm. In other cases, as in computer vision, a norm or variance normalization step, where all feature vectors are normalized to a common length, is generally used. These representations and pre-processing step map the original data from ℜp to the surface of a hypersphere Sp-1. Such representations should then be modeled using spherical distributions. However, the difficulty associated with such spherical representations has prompted researchers to model their spherical data using Gaussian distributions instead---as if the data were represented in ℜp rather than Sp-1. This opens the question to whether the classification results calculated with the Gaussian approximation are the same as those obtained when using the original spherical distributions. In this paper, we show that in some particular cases (which we named spherical-homoscedastic) the answer to this question is positive. In the more general case however, the answer is negative. For this reason, we further investigate the additional error added by the Gaussian modeling. We conclude that the more the data deviates from spherical-homoscedastic, the less advisable it is to employ the Gaussian approximation. We then show how our derivations can be used to define optimal classifiers for spherical-homoscedastic distributions. By using a kernel which maps the original space into one where the data adapts to the spherical-homoscedastic model, we can derive non-linear classifiers with potential applications in a large number of problems. We conclude this paper by demonstrating the uses of spherical-homoscedasticity in the classification of images of objects, gene expression sequences, and text data.
The effect of diastolic function on cardiac efficiency

A mathematical model that incorporates the basic features of the diastole is used; these features include nonlinear compliance, viscoelasticity, and active relaxation. Diastolic function is affected by shifts in the elastic pressure-volume curve. It is found that a significant change (up to +or-25%) in total efficiency can occur with shifts in diastolic function. >
Planting Design Effects on Avian Seed Dispersers in a Tropical Forest Restoration Experiment

Seed dispersal often limits tropical forest regeneration and animals disperse most rainforest tree seeds. This presents two important questions for restoration ecologists: (1) which animals are common seed dispersers? and (2) which restoration techniques attract them? Fourteen restoration sites were planted with four tree species in three designs, (1) controls (no planting, natural regeneration) (2) islands (trees planted in small patches), and (3) plantations (trees planted continuously over a large patch). We sampled birds in November, February, and April 2007–2008 with mist nets, in February and July 2009 with observations, and in July 2008 with both techniques. We documented 30 seed species from fecal samples of captured birds. All identified seed species were early-successional forms. Four tanager species, three thrushes, two saltators, two flycatchers, and one finch were categorized as common seed dispersers, based on their high likelihood of dispersing seeds. Common dispersers were generalist species with small gape widths (<15 mm). Common dispersers were captured significantly more often in plantations than controls in most seasons and more often in plantations than islands during one season. Common disperser observations were significantly greater in plantations than controls during two periods and in plantations compared with islands in one period. Results indicate that plantation-style planting is the conservative strategy to maximize attractiveness to common dispersers in tropical restoration sites. Island planting is an alternative when resources are limited although disperser activity may be lower in some seasons than in plantations. Additional research should investigate how to attract large, forest-associated dispersers.