cssi/SciSciGPT-SciSciNet huggingface dataset:
Robust and Efficient Video Scene Detection Using Optimal Sequential Grouping

Video scene detection is the task of dividing a video into semantic sections. We propose a novel and effective method for temporal grouping of scenes using an arbitrary set of features computed from the video. We formulate the task of video scene detection as a general optimization problem and provide an efficient solution using dynamic programming. Our unique formulation allows us to directly obtain a temporally consistent segmentation, unlike many existing methods, and has the advantage of being parameter-free. We also present a novel technique to estimate the number of scenes in the video using Singular Value Decomposition (SVD) as a low-rank approximation of a distance matrix. We provide detailed experimental results, showing that our algorithm outperforms current state of the art methods. In addition, we created a new Open Video Scene Detection (OVSD) dataset which we make publicly available on the web. The ground truth scene annotation was objectively created based on the movie scripts, and the open nature of the dataset makes it available for both academic and commercial use, unlike existing datasets for video scene detection.
Verbal stigmatization from family: How does that affect Latino men who have sex with men?:

A secondary analysis investigated the influences of verbal stigmatization from family members on the psychological well-being of Latino homosexual males. A model was proposed to explain effects of ...
Accuracy of the Cody/Waite algorithms

To assess the accuracy of the elementary functions provided by the mathcw library, it is best to let the ELEFUNT numbers speak for themselves. Table 24.1 on the next page through Table 24.23 on page 822 show typical results obtained at this author’s site and the Hewlett–Packard Test Drive Laboratory. The tables are prepared with the help of a small awk program that filters and reformats the output of make check to avoid errors from manual transcription.
Magnetotelluric imaging of lower crustal melt and lithospheric hydration in the Rocky Mountain Front transition zone, Colorado, USA

We present an electrical resistivity model of the crust and upper mantle from two-dimensional (2D) anisotropic inversion of magnetotelluric data collected along a 450 km transect of the Rio Grande Rift, southern Rocky Mountains, and High Plains in Colorado, USA. Our model provides a window into the modern-day lithosphere beneath the Rocky Mountain Front to depths in excess of 150 km. Two key features of the 2D resistivity model are (1) a broad zone (~200 km wide) of enhanced electrical conductivity (<20 Ωm) in the mid- to lower-crust that is centered beneath the highest elevations of the southern Rocky Mountains and (2) hydrated lithospheric mantle beneath the Great Plains with water content in excess of 100 ppm. We interpret the high conductivity region of the lower crust as a zone of partially-molten basalt and associated deep-crustal fluids that is the result of recent (less than 10 Ma) tectonic activity in the region. The recent supply of volatiles and/or heat to the base of the crust in the late Cenozoic implies that modern-day tectonic activity in the western United States extends to at least the western margin of the Great Plains. The transition from conductive to resistive upper mantle is caused by a gradient in lithospheric modification, likely including hydration of nominally anhydrous minerals, with maximum hydration occurring beneath the Rocky Mountain Front. This lithospheric “hydration front” has implications for the tectonic evolution of the continental interior and the mechanisms by which water infiltrates the lithosphere.
Steroid-Binding Immunoglobulins: Preparation, Properties and Application for Radioimmunoassay of Steroid Hormones

The interactions between steroids and proteins discussed so far in this monograph, and the reactions between steroids and enzymes to be dealt with in Chapter XVI, involve proteins which occur in every normal individual of a given species in about the same quantities. Normal biosynthesis, metabolism and degradation applies to these proteins which possess more or less specific binding sites for steroid molecules. No experimental procedure is known to influence the biosynthesis of the binding proteins with respect to steroid specificity, with the possible exception of bacterial enzymes.
A Two-Stage Model to Predict Surgical Patients’ Lengths of Stay From an Electronic Patient Database

Soaring healthcare costs and the growing demand for services require us to use healthcare resources more efficiently. Randomness in resource requirements makes the care delivery process less efficient. Our aim is to reduce the uncertainty in patients’ resource requirements, and we achieve that objective by classifying patients into similar resource user groups. In this article, we develop a two-stage classification model to classify patients into lower variability resource user groups by using electronic patient records. There are various statistical tools for classifying patients into lower variability resource user groups. However, classification and regression tree (CART) analysis is a more suitable method for analyzing healthcare data because it has some distinct features. For example, it can handle the interaction between predictor variables naturally, it is nonparametric in nature, and it is relatively insensitive to the curse of dimensionality. We found that the CART analysis is also useful for determining the patient attributes that can explain the variability in resource requirements. Furthermore, we observed that some of the covariates, such as the principal prescribed procedure code, the admission point, and the operating surgeon, were able to explain up to $53.43\%$ of the variability in patients’ lengths of stay (LoS). Reducing the uncertainty in patients’ LoS predictions helps us manage patient flow efficiently and subsequently obtain a better throughput.
Adoption of Responsive Neurostimulation (RNS) at a typical level 4 Epilepsy Center (P4.280)

Objective: To describe a group of patients with medically-resistant focal epilepsy with Responsive Neurostimulation (RNS) at a level 4 Epilepsy Center that was not an RNS study site. Background: About 30% of patients with epilepsy are medically intractable and require non-drug options. When potentially curative surgery is not an option or fails, neurostimulation is a viable palliative option. Vagus nerve stimulation (VNS) has been available since 1997 and has a long history, and the RNS became available in the US in 2013. As a typical level 4 center that was not a study site for RNS, we describe a series of patients who received RNS after FDA approval. Design/Methods: We retrospectively reviewed our 11 patients who received RNS after it was approved (2013). Results: Eleven patients with intractable epilepsy have been implanted with RNS since its approval. Seven patients had bitemporal epilepsy and 4 had neocortical seizure foci. Five had prior resective epilepsy surgery. Five had previously received VNS. Four patients continued on VNS therapy after receiving RNS while one was turned off due to worsening of seizures when turned on. All patients tolerated both procedures and therapies without significant adverse events. All patients remained on at least two antiepileptic medications. Conclusions: A typical surgical epilepsy center should have appropriate patients for RNS. Since RNS is much more recent than VNS, it is understandable that many RNS recipients will have previously received VNS. It is likely that, at a given center, the number of RNS patients will be smaller than the number of patients with VNS, as the indications are narrower for RNS. The two modalities can be combined safely. Disclosure: Dr. Rivera Cruz has nothing to disclose. Dr. Jayakody has nothing to disclose. Dr. Benbadis has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Cyberonics (Livanova), Eisai, Lundbeck, Neuropace, Sunovion, UCB .
Mechanisms of mitochondrial calcium transport.

Mitochondria are known to possess a rapid calcium uptake mechanism or uniport and both sodium-dependent and sodium-independent efflux mechanisms. Whether sodium-independent calcium efflux is mediated and whether sodium-dependent calcium efflux can be found in liver mitochondria have been questioned. Kinetics results relevant to the answers of these questions are discussed below.
Speaking Truth to Power: How Black/African Psychology Changed the Discipline of Psychology:

Black/African psychology is a distinct disciplinary field of psychology that includes a community of scholars and a history of scholarly inquiry. Black psychologists grounded in a Black/African psy...
Unsupervised Learning in PET Radiomics

In this study, we investigated large scale radoimics on 116 breast cancer patientstextbf{. {We are particularly interested in unsupervised learning to bicluster patients and features in order to associate such biclusters with the disease characteristics. The results show that radiomics features with wavelet features have a better biclustering ability. And 172 radiomics features have shown a better classification capability.
Interdisciplinary Care Model: Papillon-Lefèvre Syndrome and Oral Health.

Although rare, Papillon-Lefevre syndrome (PLS) is a disease that exemplifies the oral systemic continuum of findings that is representative of the need for merging medical and dental records and for promoting a closer collaboration between physicians and dentists.
Structures and Mechanical Properties of Al-Al 2 Cu Interfaces

Al-Cu eutectic composites are composed of α-Al and θ-Al2Cu phases. Al-Al2Cu interfaces play a crucial role in determining the deformation modes and mechanical properties of nanoscale Al-Cu composites. In this work, we studied the structures and properties of the $$ \left( {110} \right)_{{{\text{Al}}_{ 2} {\text{Cu}}}} \left\| {\left( {111} \right)_{\text{Al}} } \right. $$ interface and elucidated corresponding plastic deformation mechanisms by using atomistic simulations. The $$ \left( {110} \right)_{{{\text{Al}}_{ 2} {\text{Cu}}}} \left\| {\left( {111} \right)_{\text{Al}} } \right. $$ interface comprises three sets of Shockley partial dislocations that divide the interface into three types of coherent structures. The interface exhibits isotropic, low shear resistance corresponding to the easy gliding and threefold symmetry of interface dislocations. Under mechanical straining parallel to the interface, unusual slips occur on $$ \left\{ {011} \right\}_{{{\text{Al}}_{ 2} {\text{Cu}}}} $$ planes. Such an unexpected shear mode in Al2Cu phase is ascribed to the slip continuity across the Al-Al2Cu interface and the dislocations deposited at Al-Al2Cu interfaces.
Penetrating Cervical Vascular Injuries

This article reviews penetrating cervical vascular injuries, with a focus on the initial control, diagnostic workup, and operative or endovascular management. The review highlights the change in management approach from one based on anatomical zones of the neck to the contemporary approach of using physical exam and computed tomographic angiography to guide decision making. The approach to penetrating neck injuries has evolved over the past 40 years with a resultant decrease in the rate of non-therapeutic operations, driven primarily by improvements in imaging technology. The role of endovascular techniques is now established for vertebral artery injuries and continues to evolve for non-emergent carotid injuries. Penetrating cervical injuries pose a significant risk to life and triage of patients to the operating room or further imaging by computed tomographic angiography (CTA) must occur promptly based on the physical examination. In the operating room, the management of complex venous injuries consists of simple ligation. Vertebral injuries can be temporized with packing or bone wax and then managed with percutaneous endovascular interventions. Carotid injuries may generally be managed with arteriorrhaphy, primary repair, or reconstruction with venous or PTFE graft. In damage control situations, shunting is preferred.
Treatment of feline injection-site sarcoma with surgery and iridium-192 brachytherapy: retrospective evaluation of 22 cats:

ObjectivesThe aim of this retrospective descriptive study was to determine the effectiveness of using iridium implants in addition to surgery in cats with feline injection-site sarcomas (FISSs) in ...
Abstract 891: Plumbagin and atovaquone inhibit Na+/K+-ATPase through the generation of oxidative stress

Plumbagin and atovaquone are chemotoxic to ovarian, breast and other tumors. Both molecules inhibit oxidative phosphorylation causing a rapid increase in intracellular oxygen radicals and apoptosis. Oxidative stress is also known to inhibit the activity of Na+/K+-ATPase (NKA), the ion channel that maintains the membrane potential. Here, we investigate if the oxidative stress mediated by plumbagin and atovaquone also leads to inhibition of NKA activity. We confirm that plumbagin and atovaquone inhibit proliferation of three human (OVCAR-3, SKOV-3 and TYKNu) and one mouse (ID8) ovarian cancer cell lines. Using SKOV-3 and OVCAR-3 as models for ovarian cancer, we demonstrate that oxygen radical scavenger, N-acetylcysteine (NAC) attenuated the cytotoxicity of plumbagin and atovaquone. Using whole cell patch clamping we demonstrate that plumbagin and atovaquone inhibit outward and inward current flowing through NKA in SKOV-3 and OVCAR-3. Both drugs decrease cellular ATP. Providing exogenous ATP (5 mM) in the pipet solution used during patch clamping did not recover NKA activity in the plumbagin or atovaquone treated SKOV-3 and OVCAR-3 cells. However, pretreatment of the cells with NAC completely abrogated the NKA inhibitory activity of plumbagin and atovaquone. Exposure of the SKOV-3 cells to either of the drugs for 1-2 h resulted in a significant decrease in the expression of NKA. We conclude that oxidative stress caused by plumbagin and atovaquone degrades NKA and hence the membrane potential cannot be optimally maintained. Evaluation of compounds that induce oxidative stress should therefore consider contribution of NKA inhibition to the cytotoxic activity of such agents. Citation Format: Yousef Alharbi, Arvinder Kapur, Mildred Felder, Lisa Barroilhet, Bikash Pattnaik, Manish S. Patankar. Plumbagin and atovaquone inhibit Na+/K+-ATPase through the generation of oxidative stress [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 891.
Attachment to God and Social Trust

Research suggests that religious participation is associated with feelings of social trust. A separate line of work shows that individuals who develop secure, intimate relationships with parents, c...
Gold plasmonic material for enhanced Hg1–xCdxTe infrared absorption

There are potential applications for high operating temperature (HOT) Hg1-xCdxTe (MCT) infrared (IR) devices for both defense and commercial applications. MCT absorption can be raised either by increasing the absorber thickness or by lowering the operating temperature. However, if we can increase MCT absorption by using plasmonic materials, it will help in both HOT operation and increasing signal to noise ratio. We studied three Gold (Au) plasmonic structures for the absorption enhancement of MCT materials in the wavelength band of 3-7 μm. By using RF module in COMSOL multiphysics software, we found a large increase (1.85X) of MCT absorption when the optimized Au plasmonic structure is used. The increase in absorption at 4.5-6 μm is higher than that at 3-4 μm. The increased absorption due to plasmonic structure allows absorber thickness to decrease which leads to decrease in dark current and HOT devices. We report here record 90% increase in absorption of MCT material at room temperature at peak wavelength around 3.4 μm by using optimized plasmonic structure.
Symmetry-Imposed Rectangular Coprime and Nested Arrays for Direction of Arrival Estimation With Multiple Signal Classification

Linear sparse arrays (coprime and nested arrays) have been studied extensively as a means of performing direction of arrival (DoA) estimation while bypassing Nyquist sampling theorem. However, rectangular sparse arrays have few studies, most of which are based in lattice theory. Although the multiple signal classification (MUSIC) alogrithm can be applied to lattice theory-based sparse arrays, fewer DoAs can be estimated for these arrays than for a full array with the same aperture. One contribution of this paper is the formulation of symmetry-imposed rectangular coprime and nested array designs that have wider contiguous lags than lattice-based arrays. Also, existing algorithms for rectangular arrays employ the direct sample covariance matrix estimate, which has low accuracy. Another contribution of this paper is an alternate method for estimating the covariance matrix that ensures the matrix is block-Toeplitz. Using the proposed covariance matrix estimate, we integrate a MUSIC-based DoA estimation method that applies to both full arrays and sparse arrays. The results show that the covariance estimates produced by the proposed method have higher accuracy than the traditional sample covariance estimates. The results also demonstrate that symmetry-imposed sparse arrays have higher resolution than full rectangular arrays with the same number of sensors.
Framing authority in language policy debates

Abstract This paper explores the ways in which authority is discursively claimed and negotiated. Working within the social context of debates over orthographic reform in France, I examine how participants in a televised debate address this notion through orientation to competing chronotopes; participants in the debate engage in processes of scale-making as they argue which time-space(s) are most relevant and how those time-spaces should be understood. Thus, this paper argues that authority is not simply synonymous with social and/or political power but should be understood through the processes by which it is claimed, leading to an understanding of authority as a dynamic construct that is continually negotiated.
Now, Over Here: Leveraging Extended Attentional Capabilities in Human-Robot Interaction

Competent collaboration between robots and people in the open world requires sensing and reasoning about transitions of people's attention to the robots themselves, as well as to other people and objects in the environment. We present challenges and opportunities with designing extended attentional capabilities for interactive systems, including the need to track, reason about, and manage the attentional foci of all actors. We describe work in progress to leverage such attentional capabilities for interaction management with a prototype situated robotic system.
Water distribution networks as flexible loads: A chance-constrained programming approach

Abstract There is a greater need for flexibility in the power distribution network (PDN) due to increasing levels of renewable energy resources. Here, we consider using the water distribution network (WDN) as a flexible load. We formulate a chance-constrained multiperiod optimization problem to schedule water distribution pumps subject to WDN and PDN constraints while managing power demand forecast uncertainty. To do that, we develop a control policy that adjusts the WDN’s operation when a PDN constraint violation is present. Since the resulting problem is nonconvex, we utilize approximation and relaxation techniques to transform the problem into a convex program and solve via the scenario approach. Through detailed case studies, we verify the performance of the control policy to ensure network constraints are satisfied despite uncertainty. We find that we can successfully schedule and control the WDN to provide flexibility to the PDN for many realistic water and power demand scenarios.
Infectious Myocarditis on FDG-PET Imaging Mimicking Sarcoidosis

Cardiac positron emission tomography with fluorine-18 fluorodeoxyglucose (FDG-PET) is often used for the diagnosis of cardiac involvement in sarcoidosis. Areas of segmental perfusion defects coupled with FDG uptake are considered to represent active inflammation. However, these findings may be associated with other inflammatory myocardial diseases. We describe a case of tuberculous myocarditis with imaging findings mimicking those found in cardiac sarcoidosis.
Antiplatelet Agent Reversal Is Unnecessary in Blunt Traumatic Brain Injury Patients Not Requiring Immediate Craniotomy

BackgroundThe need to reverse the coagulation impairment caused by chronic antiplatelet agents in traumatic brain injury (TBI) patients with acute traumatic intracerebral hemorrhage (TICH) remains ...
Levels of Illness Uncertainty Vary by Heart Failure Symptom Cluster Group

Background Heart failure patients experience multiple concurrent symptoms called symptom clusters. Understanding the role and characteristics of symptom clusters in heart failure (HF) patients is limited. Illness uncertainty may lead to difficulty interpreting symptoms and timely treatment. Before person-centered interventions can be developed, more information about variations in HF symptom clusters and factors associated with them are needed. Purpose The purpose of this study was to describe HF symptom clusters and determine if illness uncertainty levels differed by symptom cluster. Methods A total of 129 HF patients (mean age 76.4 (12.4) years, education 10.6 (3.2) years and time with HF 3.6 (5.9) years, 54% male, 93% Caucasian, 46% widowed/divorced, NYHA class III) completed the Heart Failure Somatic Perception Scale (HFSPS, 0-90, higher score indicates more symptoms) and Mishel's Uncertainty in Illness Scale (MUIS, 23-115, higher score indicates more uncertainty) during hospitalization. Symptom clusters were determined by hierarchical agglomerative clustering techniques in SPSS 25. After controlling for differences in age, gender and length of time with HF, ANCOVA (post hoc LSD) analyses explored uncertainty levels by symptom cluster group. Results Three clusters were found: 1. Shortness of breath cluster (SOB), n = 43 (fatigue, hard to breathe, SOB when dressing, orthopnea, DOE, PND, rest during day, wake urinate at night), 2. Edema cluster, n = 47 (swollen feet, tight shoes, tight clothes, weight gain), 3. Cardiac symptom cluster, n = 39 (palpitations, chest pain, upset stomach, decreased appetite, cough). After adjusting for age, gender and length of time with HF, there was a significant difference in uncertainty levels by symptom cluster group (p = .000). Post hoc analysis demonstrated that cardiac cluster members reported less illness uncertainty than edema cluster members (69.7 vs 75, respectively, p = .033). Conclusions Results suggest that significant differences exist in illness uncertainty levels based on the symptom experience of patients with HF. Care and management of HF symptoms should include a complete assessment of unique symptom cluster profiles.
Assessment of gastric electrical activity and autonomic function among diabetic and nondiabetic patients with symptoms of gastroesophageal reflux.

Gastroesophageal reflux disease (GERD) may present differently in patients with diabetes mellitus (DM) than in nondiabetics (NDM). We compared three tests in two patient groups with GERD symptoms: a DM group (n = 10) and a NDM group (n = 13). The tests were 24-hr esophageal pH, autonomic function testing (AFT), and electrogastrography (EGG). Analysis of the 23 patients revealed the DM group had normal 24-hr pH values (9 of 10 patients, mean pH 3.1 ± 1.7), while NDM displayed abnormal pH values (9 of 13 patients, mean pH 21.2 ± 5.9). AFT results were abnormal in DM (demonstrating cholinergic/adrenergic dysfunction), but normal in NDM. EGG values were abnormal in both groups (mean 3.31 ± 0.1 in each). We conclude that in GERD-symptomatic patients, those with DM frequently have normal 24-hr pH, but abnormal autonomic functioning, in contrast to NDM, who have abnormal 24-hr pH but normal autonomic function. Both groups had identically abnormal mean EGG values.
Sounded histor-futurit-ies: Imagining posthuman possibilities of race and place in qualitative research

This paper examines how histories of racism, slavery, and white supremacy continue to resonate in the present through the creation and curation of an audio compilation of student narratives. Ground...
Vaccine Hesitancy in North Carolina: The Elephant in the Room?

Vaccine hesitancy is a persistent but under-prioritized issue in North Carolina. Plans are needed for systematic data collection on vaccine hesitancy trends, enhancing access to trusted sources of information, strengthening policies encouraging vaccinations, and reducing missed vaccination opportunities to inform a multifaceted strategy for reducing vaccine hesitancy in North Carolina.
Multi-Centered Worlds, Limited Accessibility and Ways of Believing

Recent descendants of David Lewis, such as Stephen Torre, Dilip Ninan, and Dirk Kindermann have utilized multi-centered propositions, which are roughly sets of possible worlds centered on a sequence of individuals, to characterize the content of attitudes. In an attempt to explain counterfactual attitudes such as wishing and imagining, Ninan (2012, 2013) developed a more fine-grained characterization of multi-centered propositions than others in the multi-centered camp. While Ninan provides a systematic explanation of the nature of de se attitudes (attitudes one expresses with first-person pronouns like ‘I’ or ‘me’), the nature of other types of indexical attitudes (attitudes one expresses with indexical terms like ‘you,’ ‘today,’ ‘now,’) is not explored. This paper does two things. First, it demonstrates how we can account for indexical attitudes within Ninan’s framework. This, however, has the consequence of generating propositions of limited accessibility of sorts, which in turn conflict with a received and simple model of linguistic communication. According to this simple model, successful communication consists of the transmission of mental content from speaker to hearer. Second, in light of this conflict, the paper proposes an adjustment to Ninan’s theory in order to avoid commitment to propositions of limited accessibility, and thus preserve the shareability of attitudinal content from speaker to hearer.
Dean, Jodi. (2019). Comrade: An Essay on Political Belonging . New York: Verso Books. Hardcover: $19.95

Jodi Dean’s Comrade: An Essay on Political Belonging positions the word comrade against the popular term ally. Dean argues that the idea of the comrade is more collective than ally, which focuses on individual identity. Contrary to stereotypes of the comrade figure as only a white male one, Dean traces the rich history of women and comrades of color in the communist movement. She reasons that what binds comrades together is not based on shared identity, but rather the action of a shared struggle.
The set of solutions of a polynomial-exponential equation

l∈λ Pl(x)αl = 0 (λ ∈ P). Denote by S(P) the set of solutions of (1.1)P which do not satisfy (1.1)Q for any proper refinement Q of P (notice that every solution of (1.1) lies in S(P) for some partition P). Then let G(P) be the subgroup of Z consisting of x such that αl = α x m whenever l and m lie in the same set λ of P. Let d be the degree of the field K, and for l ∈ Λ let δl be the total degree of the polynomial Pl. Set
Substrate Interactions with Nitrogenase and its Fe-Mo Cofactor: Chemical and Spectroscopic Investigations

Substrate interactions with nitrogenase embrace two formally separable phenomena binding and reduction of N2, or alternate reducible substrates; and binding and hydrolysis of ATP, which requires dissociation of ADP from the hydrolysis site to continue turnover. Not considered here is the interaction of nitrogenase with its immediate electron donor, which is a metalloprotein in vivo and usually sodium dithionite for assays in vitro. Investigations of reductions by nitrogenase have chiefly examined chemical aspects, such as substrate reactivities or product formation kinetics. Alternate substrates are useful as probes of reduction mechanisms, as we have shown by the discovery that certain molecules having a double bond within a three-membered ring are reduced by nitrogenase (McKenna, 1980; McKenna et. al., 1980a, 1980b). It is generally assumed that the active site for N2 reduction is located on the nitrogenase Fe-Mo protein, although direct, conclusive evidence to support this assumption is still lacking. Indirect evidence and also intuition supports an important role for Mo in the reduction mechanism. Since both Mo atoms in the FeMo protein are contained in its Fe-Mo-S clusters (FeMo-cofactor, FeMo-co) this cluster has accordingly been regarded as a likely component of the active site of reduction. Prior evidence for nucleotide binding to the Fe protein has come from spectroscopic, equilibrium partitioning and other studies.
Techniques for Statistical Debugging

Thus far we have focused on techniques for collecting sparsely sampled data from large numbers of users. However, this data is only as good as the sense we can make of it. This chapter presents several techniques for using sparsely sampled data to isolate the causes of bugs.
Gorillas with spondyloarthropathies express an MHC class I molecule with only limited sequence similarity to HLA-B27 that binds peptides with arginine at P2.

The human MHC class I gene, HLA-B27 , is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies (SpAs). HLA-B27 -transgenic rodents develop SpAs, implicating HLA-B27 in the etiology of these disorders. Several nonhuman primates, including gorillas, develop signs of SpAs indistinguishable from clinical signs of humans with SpAs. To determine whether SpAs in gorillas have a similar HLA-B27 -related etiology, we analyzed the MHC class I molecules expressed in four affected gorillas. Gogo-B01, isolated from three of the animals, has only limited similarity to HLA-B27 at the end of the α1 domain. It differs by several residues in the B pocket, including differences at positions 45 and 67. However, the molecular model of Gogo-B*0101 is consistent with a requirement for positively charged residues at the second amino acid of peptides bound by the MHC class I molecule. Indeed, the peptide binding motif and sequence of individual ligands eluted from Gogo-B*0101 demonstrate that, like HLA-B27, this gorilla MHC class I molecule binds peptides with arginine at the second amino acid position of peptides bound by the MHC class I molecule. Furthermore, live cell binding assays show that Gogo-B*0101 can bind HLA-B27 ligands. Therefore, although most gorillas that develop SpAs express an MHC class I molecule with striking differences to HLA-B27, this molecule binds peptides similar to those bound by HLA-B27.
Helping a Group of Adolescents in a Mental Hospital Handle Separation Anxiety through the Planning of the Farewell Party for the Doctors (Hillside Hospital, Adolescent Pavilion, 1958)

In this process recording the author describes her work over a 4-day period (June 6 – June 5, 1958) with a group of adolescent girls who are in the midst of long-term hospitalization in a private psychiatric hospital. These teens are dealing with the upcoming loss of several of their doctors. The author views them as members of a community—the hospital. The author helps them to voice their feelings and needs effectively to the hospital staff.
Prolactin production during in vitro decidualization of proliferative endometrium

Abstract Decidua obtained in the late luteal phase of the human menstrual cycle has been shown to produce immunoreactive prolactin (PRL). The amount of PRL produced is a function of the extent of decidual differentiation. Further, the maintenance of decidualization and PRL production in specimens of late luteal phase in explant culture is dependent on the presence of progesterone (P). To further examine P's effect on decidualization, PRL production was monitored during P-induced decidualization of proliferative endometrium in vitro. Samples of proliferative endometrium obtained from six hysterectomy specimens were cultured in Dulbecco's modified Eagle medium in the presence of no hormones, 200 pg/ml estradiol (E 2 ) 20 ng/ml P, and 20 ng/ml P with 200 pg/ml E 2 . It was found that P alone or with E 2 caused PRL production and histologic decidualization. However, E 2 slowed the histologic progression of P-induced decidualization on days 2 and 4 and decreased the rate of PRL production (p 2 can modify the rate and/or extent of this P-mediated phenomenon.
Highly Differentiated Populations of the Narrow Endemic Plant Maguire Primrose (Primula maguirei)

Maguire primrose (Primula maguirei) is a geographically restricted plant species, known only from a 19-km stretch of Logan Canyon in northern Utah (U.S.A.). We examined variation at 13 isozyme loci from 25 individuals of P. maguirei at each of eight sites. At individual loci we detected no statistically significant deviations from Hardy-Weinberg proportions within sites (subpopulations). However, some loci were almost fixed for different alleles at the upper reaches of the species’ range relative to populations approximately 10 km away. The total mean gene diversity among loci was 0.22, of which 55% was partitioned within subpopulations, 0.7% among subpopulations within populations (100 m spatial scale), 3% among populations separated by about 1 km, and 41% between an Upper Canyon group of populations and a Lower Canyon group (10-km scale). We detected no gametic disequilibria among loci within subpopulations (and populations). Two hypotheses are proposed to explain the results: (1) past genetic bottlenecks and (2) genetic divergence as a by-product of local adaptations to different habitats. Regardless of the causes of allozymic differentiation, our results suggest that plans for artificial establishment or reestablishment of P. maguirei populations should use source populations within 1 km of the establishment site. This study emphasizes the potential use of data on population genetic structure for managing and monitoring rare species. La primula Maguire (Primula maguirei) es una especie de planta geograficamente restringida, que unicamente se conoce en una extension de 19 km en el Canon de Logan en el norte de Utah (E.U.A.). Examinamos la variacion de 13 loci de isozimas de 25 individuos de P. maguire en ocho localidades. No detectamos desviacion significativa de las proporciones Hardy-Weinberg entre localidades (subpoblaciones) en loci individuales. Sin embargo, algunos loci estaban casi fijos en diferentes alelos en los limites superiores del rango de la especie en relacion con poblaciones alejadas aproximadamente 10 km. El promedio total de diversidad genetica entre loci fue de 0.22, de la que 55% estaba repartida entre subpoblaciones, 0.7% entre subpoblaciones dentro de las poblaciones (escala espacial de 100 m), 3% entre poblaciones separadas casi 1 km, y 41% entre un grupo de poblaciones de la parte superior del canon y otro de la parte inferior (escala de 10 km). No detectamos desequilibrio gametico entre loci de subpoblaciones (y poblaciones). Se proponen dos hipotesis para explicar los resultados: 1) cuello de botella geneticos en el pasado y 2) divergencia genetica como consecuencia de adaptaciones locales a habitats diferentes. Independientemente de las causas de la diferenciacion alocimica, nuestros resultados sugieren que planes para el establecimiento o re-establecimiento artificial de poblaciones de P. maguire deben utilizar individuos provenientes de sitios localizados a 1 km este estudio enfatiza el uso potencial de datos de la estructura genetica para el manejo y monitoreo de especies raras.
Application of antiferromagnetic-Fermi-liquid theory to NMR experiments in La1.85Sr0.15CuO4.

NMR experiments on La{sub 1.85}Sr{sub 0.15}CuO{sub 4} by Kitaoka {ital et} {ital al}. and Imai {ital et} {ital al}. are analyzed using the phenomenological antiferromagnetic (AF) Fermi liquid theory of Millis, Monien, and Pines, and the results are compared with those previously obtained for YBa{sub 2}Cu{sub 3}O{sub 7} and YBa{sub 2}Cu{sub 3}O{sub 6.63}. A one-component model, with hyperfine couplings that are unchanged from those found previously for YBa{sub 2}Cu{sub 3}O{sub 7} and YBa{sub 2}Cu{sub 3}O{sub 6.63}, and parameters obtained from experiment, provide a quantitative fit to the data. At all temperatures the antiferromagnetic correlations found in La{sub 1.85}Sr{sub 0.15}CuO{sub 4} are stronger than those found for the Y-Ba-Cu-O samples with the result that the characteristic energy for the antiferromagnetic paramagnons that describe the AF spin dynamics is quite low ({lt}{ital kT} and {similar to}20 K at {ital T}{sub {ital c}}). We use the deduced paramagnon energies to calculate the contribution to the electrical resistivity from quasiparticle-antiferromagnetic paramagnon scattering for La{sub 1.85}Sr{sub 0.15}CuO{sub 4}, YBa{sub 2}Cu{sub 3}O{sub 7}, and YBa{sub 2}Cu{sub 3}O{sub 6.63}, and find that it displays a linear temperature dependence for all three materials. Our results support the proposal that the properties of a nearly antiferromagnetic Fermi liquid aremore » genuinely novel, and suggest that both the spin and charge aspects of the normal-state properties of the cuprate oxide superconductors can be quantitatively explained in terms of quasiparticles coupled to antiferromagnetic paramagnons whose characteristic energy scale is {lt}{ital kT}.« less
No sea ignorante: la dispersión de precios no es una medida de la ignorancia en el mercado

Uno de los puntos de Stigler en su germinal trabajo The Economics of Information fue que “la dispersion de precios es una manifestacion –y, de hecho es la medida- de la ignorancia en el mercado”. Esta aseveracion ha perdurado como parte del acervo de la disciplina desde entonces, y ha sido usada extensamente en trabajos empiricos. En este trabajo, se demuestra que, en los modelos de equilibrium search theory, no existe una correlacion inequivoca entre la ignorancia de los consumidores y la dispersion de precios. Por tanto, la dispersion no puede ser usada como una medida de la ignorancia. El hecho de que los consumidores esten menos informados (sean mas ignorantes) genera mayor poder de mercado y por lo tanto precios mas altos, aunque no necesariamente afecta la varianza de los precios entre distintas firmas. La intuicion es que el mayor poder de mercado no necesariamente afecta de forma diferenciada a los vendedores de precios altos en contraposicion a los vendedores de precios bajos.
Understanding and treating the psychopath

THEORETICAL Issues Definition of Psychopathy and Criteria for the Evaluation of Theory Gough's Theory Psychopath as Deficient in Role-Playing Abilities Bysenck's Theory Psychopath as Genetically Predisposed Deficient Learner Quay's Theory Psychopath as a Pathological Stimulation Seeker Hare's Theory Psychopathy as Biologically Based Response Perservation Integrative Theory Psychopathy as the Persistent Challenge for Environmental Control TREATMENT ISSUES Preliminary Issues in the Treatment of Psychopathy General Treatment Issues Specific Direct'' Behaviors of Psychopaths Nonverbal Behaviors Specific Nondirect'' Behaviors of Psychopaths Designed to Obtain Environmental Control A Final Word Author Index Subject Index.
Introspective utility and the group choice problem

This paper presents empirical evidence somewhat supportive of the hypothesis that von Neumann-Morgenstern utility and so-called ‘introspective utility’ are intrinsically the same. In other words, this evidence is somewhat supportive of theview that the Allais Paradox and related phenomena are more apparent than real. The bearing that this evidence has on the relationship between two methods of group choice is discussed.
A CLINICAL STUDY OF THE EFFECTS OF MAMMARY GLAND SUBSTANCE UPON UTERINE FUNCTION

Briggs (4) says: “Fortunately, in the mammary gland we have a powerful physiologic remedy which either antagonizes or neutralizes the ovarian hormone or inhibits its production or possibly acts more directly on uterine circulation and nutrition.”He reports a series of twenty-five cases of uterine fibroids with menorrhagia and metrorrhagia, treated exclusively by mammary extract, hydrastis and ergot. Seventeen of these patients, ranging in age from twenty-six to fifty-six, recovered completely. Ernil Novak (11), in. discussing this series, says: “I am frank to say.that I have never employed this therapeutic agent for such purposes, but I am reasonably sure that it has been similarly neglected by the overwhelming majority of gynecologists and that this neglect is based upon more or less well founded skepticism as to its virtue.”
Predictions of the Existence, Frequency, and Amplitude of Physiological Tremor in Normal Man Based on Measured Frequency-Response Characteristics

Mathematical models for 1) musculoskeletal dynamics, and 2) reflex feedback, based on the results of the authors' frequency-response measurements on normal adult male human subjects, are combined to produce a model for physiological tremor in such subjects. An analysis of this model shows that the system will be unstable to small disturbances (that is, tremor will occur) under certain conditions of external loading. Further, when the system is unstable, nonlinearities in the model produce responses in the form of limit cycles, and both the frequency and amplitude of the resulting tremor can be calculated. For constant loads applied through a constant compliance, the model predicts the onset of tremor at low loads, a maximum intensity of tremor at loads corresponding to 30-50 percent of maximum voluntary effort, and a decrease in the tremor amplitude at still higher loads.
Patient education in the hospital health-care setting.

Abstract The implementation of patient education within the hospital setting can be justified for a variety of reasons. The rationale for implementing patient education can be justified in terms of escalating emphasis on consumerism and informed participation on the part of the health-care recipient, the support of federal legislation, the support of hospital regulatory bodies, the support of third-party insurance carriers and private foundations, increased cooperation and compliance on the part of the patient, reduced stress levels for the hospitalized patient, and the improvement of staff-patient relationships. All of these serve as a database that justifies the integration of patient education within hospital care services. Patient education is the responsibility of the existing health-care system. In many instances, patient education is still not being approached in a serious manner. Therefore this paper attempts to provide a number of reasons health-care professionals functioning within the hospital setting should implement this process.
Development of Functional Diarrhea, Constipation, Irritable Bowel Syndrome, and Dyspepsia During and After Traveling Outside the USA

Background Persistent gastrointestinal (GI) symptoms after travel abroad may be common. It remains unclear how often subjects who developed new GI symptoms while abroad have persistent symptoms on return. The objective of this retrospective study was to evaluate the prevalence of persistent GI symptoms in a healthy cohort of travelers. Methods One hundred and eight consecutive patients, mostly returned missionaries, attending the University of Utah International Travel Clinic for any reason (but mostly GI symptoms) had data recorded about their bowel habits before, during, and after travel abroad. All subjects had standard hematological, biochemical, and microbiological tests to exclude known causes of their symptoms. Endoscopic procedures were performed when considered necessary by the treating physician. Diarrhea, constipation, irritable bowel syndrome (IBS), bloating, and dyspepsia were defined according to the Rome II Criteria. Results Eighty three (82% men and 18% women, median age 21 years) completed the survey with 68 subjects completing the questionnaire about bowel habits before and during travel. Among the respondents, 55 (82.1%) did not have any symptoms before travel. During travel, 41 (63%) developed new onset diarrhea; 6 (9%) developed constipation; 16 (24%) IBS, 29 (45%) bloating; and 11 (16%) dyspepsia. Of those who developed symptoms during travel, 27 (68%) had persistent diarrhea, 3 (50%) had persistent constipation, 10 (63%) had persistent IBS, 12 (43%) had persistent bloating and 8 (73%) had persistent dyspepsia. The presence of bowel symptoms during and after travel was not associated with age, gender, travel destination, or duration of travel. Conclusions: This study suggests that new onset of diarrhea, IBS, constipation, and dyspepsia are common among subjects traveling abroad. Gastrointestinal symptoms that develop during travel abroad usually persist on return.
Purification of Alkaline Phosphatase by Ultrafiltration in a Stirred Batch Cell

Abstract The purification of a crude grade of bovine intestinal alkaline phosphatase by ultrafiltration has been studied. The purification process utilized a small stirred ultrafiltration cell operated in a batch mode to purify the enzyme. An Amicon YM100 membrane proved effective by recovering high amounts of enzyme activity and allowing the crude enzyme to be purged of its lower molecular weight impurities, which were mostly albumin. Studies were done utilizing various buffers, operating pressures, and stirrer speeds. Extensive investigation of the latter two parameters showed that stirrer speed was the most significant factor in decreasing flux decline and improving separation efficiency.
Note on Variations in the “Quasi-Biennial” Oscillation

Data compiled since 1962 are examined in an effort to quantify further the observed variations in the 'quasi-biennial' oscillation (QBO). A further study of temperatures and zonal winds is conducted for Canton Island, Ascension Island, and Balboa, C.Z. Statistics are derived for the period of record prior to 1962 and for that subsequent to 1962. The results of the investigation suggest that the QBO has remained in roughly geostrophic equilibrium since it was first observed.-
Mechanism of injury from air bag deployment loads

Loadings induced by deploying currently representative air bags were studied with driver surrogates (anesthetized swine) leaning against the system during inflation. Torso injury mechanisms were studied in a physiologic model, supported against a static steering wheel-mounted air bag system. Severe and extensive chest and abdominal injuries to the swine were observed in the tests. Loading caused by air bag deployment can occur in either of two phases. The first phase represents the initial punch out of the bag from the module; the second phase represents the membrane force of the inflating bag. Statistical analysis indicated that punch out induced injury because of the high rate of loading to the surrogate body region in direct contact with the air bag module. Membrane forces induced injury by high compression over a larger area. Punch-out loading might be reduced by allowing the bag to escape from other parts of the container not in contact with the driver during deployment. Loading by the inflating bag might be reduced by using a compliant steering system to support the module. The amount and rate of generated gas had only marginal effect on the cumulative injury. Even an inflator with inadequate gas output to protect a properly seated occupant had sufficient energy to induce severe injuries in a surrogate in contact with the inflating module. Analysis of the field relevance of the results must consider not only the injury potential given that a driver is in direct contact with the air bag module at the time of deployment, but also the expected field frequency of such an event. Analysis of the field relevance of the results must also consider the correlation of the laboratory test environment with real-world exposure.