cssi/SciSciGPT-SciSciNet huggingface dataset:
Effects of intravenous and intracoronary nicardipine.

Abstract The systemic and coronary hemodynamic effects of nicardipine, a calcium antagonist, were studied in 30 patients. Increased coronary blood flow (from 102 ± 9 to 147 ± 13 ml/min; p To distinguish between direct myocardial effects of nicardpine and peripheral effects, 15 patients were given intracoronary nicardipine (0.1 or 0.2 mg) during cardiac catheterization. Nicardipine produced slight depression of left ventricular contractile function and impairment of left ventricular relaxation; but these changes were mild and transient compared with the marked and sustained increase in coronary blood flow that persisted 7 minutes after administration. Thus, nicardipine is a relatively selective vasodilator with minimal direct myocardial depressant activity in humans.
Numerical Study of Liquid Film Microstructure During Spin Coating of Ag Colloidal Suspension

A multiple time-step discrete-element approach is employed to model the transport, collision and adhesion of small silver (Ag) colloidal particles in a spin coating process. The three-dimensional (3D) particle motions are computed using a combination of fluid-induced forces and torques, and forces and torques induced by the particle collision and adhesion forces. These analysis are used to predict the final aggregate size distribution and microstructure during the non-evaporative phase of spin coating of a thin film, which is important for controlling the abrasiveness, opacity, conductivity, and other properties of the film, as well as for using the deposited particles for growing new materials (e.g., nanotubes). The computations examine the effect of adhesion potential, volume concentration, and spin speed effects on the distribution of particle aggregate sizes and their deposition during spin coating. The aggregates are observed to be primarily governed by these parameters, as has previously been observed in experiments. The results provide a fundamental understanding of the physics of thin film spin coating processes and insight in to microstructure control during the coating process.Copyright © 2009 by ASME
The impregnability of American linguistics: An historical sketch

Abstract Examination of the conflict between the mechanists (such as Bloomfield and Hall) and the mentalists (such as Spitzer and Chomsky) in American linguistics reveals that, despite irreconcilabe differences, both schools are committed to a conception of science that prohibits debate on the fundamental issues. The party in power can and does change, but debate is always stifled by means of dismissing the outsiders as unscientific. For both, it is enough that linguistic inquiry be conducted scientifically for linguistic science to emerge. But what the nature and limits of such inquiry are, they neither agree upon nor debate. Consequently, the field is characterized by increasing paralysis, which spreads behind a facade rendered impregnable by the joint defense of irreconcilable opponents.
Public Health Implications for Adequate Transitional Care for HIV-Infected Prisoners: Five Essential Components

In the United States, 10 million inmates are released every year, and human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) prevalence is several-fold greater in criminal justice populations than in the community. Few effective linkage-to-the-community programs are currently available for prisoners infected with HIV. As a result, combination antiretroviral therapy (cART) is seldom continued after release, and virological and immunological outcomes worsen. Poor HIV treatment outcomes result from a myriad of obstacles that released prisoners face upon reentering the community, including homelessness, lack of medical insurance, relapse to drug and alcohol use, and mental illness. This article will focus on 5 distinct factors that contribute significantly to treatment outcomes for released prisoners infected with HIV and have profound individual and public health implications: (1) adaptation of case management services to facilitate linkage to care; (2) continuity of cART; (3) treatment of substance use disorders; (4) continuity of mental illness treatment; and (5) reducing HIV-associated risk-taking behaviors as part of secondary prevention.
On the variable order dynamics of the nonlinear wake caused by a sedimenting particle

Abstract In this work we develop a variable order (VO) differential equation of motion for a spherical particle sedimenting in a quiescent viscous liquid. In particular, we examine the various force terms in the equation of motion and propose a new form for the history drag acting on the particle. We show that the variable order formulation allows for an effective way to express the dynamic transition of the dominant forces over the entire time of the motion of the particle from rest to terminal velocity. The use of VO operators also allows us to examine the evolving dynamics of the wake during sedimentation. Using numerical data from a finite element simulation of a sedimenting particle, we first solve for the order of the derivative that returns the correct decay of the history force. We then propose a relatively simple expression for the history force that is a function of the Reynolds number and particle-to-fluid density ratio. The new history drag expression correlates very well ( R 2 > 0.99 ) with the numerical data for terminal Reynolds numbers ranging from 2.5 to 20, and for particle-to-fluid density ratios of interest in practice ( 1 β 10 ).
Autologous endothelial progenitor cell-seeding technology and biocompatibility testing for cardiovascular devices in large animal model.

Implantable cardiovascular devices are manufactured from artificial materials (e.g. titanium (Ti), expanded polytetrafluoroethylene), which pose the risk of thromboemboli formation1,2,3. We have developed a method to line the inside surface of Ti tubes with autologous blood-derived human or porcine endothelial progenitor cells (EPCs)4. By implanting Ti tubes containing a confluent layer of porcine EPCs in the inferior vena cava (IVC) of pigs, we tested the improved biocompatibility of the cell-seeded surface in the prothrombotic environment of a large animal model and compared it to unmodified bare metal surfaces5,6,7 (Figure 1). This method can be used to endothelialize devices within minutes of implantation and test their antithrombotic function in vivo. Peripheral blood was obtained from 50 kg Yorkshire swine and its mononuclear cell fraction cultured to isolate EPCs4,8. Ti tubes (9.4 mm ID) were pre-cut into three 4.5 cm longitudinal sections and reassembled with heat-shrink tubing. A seeding device was built, which allows for slow rotation of the Ti tubes. We performed a laparotomy on the pigs and externalized the intestine and urinary bladder. Sharp and blunt dissection was used to skeletonize the IVC from its bifurcation distal to the right renal artery proximal. The Ti tubes were then filled with fluorescently-labeled autologous EPC suspension and rotated at 10 RPH x 30 min to achieve uniform cell-coating9. After administration of 100 USP/ kg heparin, both ends of the IVC and a lumbar vein were clamped. A 4 cm veinotomy was performed and the device inserted and filled with phosphate-buffered saline. As the veinotomy was closed with a 4-0 Prolene running suture, one clamp was removed to de-air the IVC. At the end of the procedure, the fascia was approximated with 0-PDS (polydioxanone suture), the subcutaneous space closed with 2-0 Vicryl and the skin stapled closed. After 3 - 21 days, pigs were euthanized, the device explanted en-block and fixed. The Ti tubes were disassembled and the inner surfaces imaged with a fluorescent microscope. We found that the bare metal Ti tubes fully occluded whereas the EPC-seeded tubes remained patent. Further, we were able to demonstrate a confluent layer of EPCs on the inside blood-contacting surface. Concluding, our technology can be used to endothelialize Ti tubes within minutes of implantation with autologous EPCs to prevent thrombosis of the device. Our surgical method allows for testing the improved biocompatibility of such modified devices with minimal blood loss and EPC-seeded surface disruption.
Energy-efficient MIMO detection using unequal error protection for embedded joint decoding system

This paper presents a low-power multiple-input multiple-output (MIMO) and H.264 video joint detector/decoder design that minimizes energy for portable, wireless embedded systems. The design combines an unequal error protection (UEP) scheme with a variable fidelity of MIMO detection, making performance and energy consumption tradeoffs as required by the importance of each coded video frame. Using search space reduction/truncation strategies in MIMO detection along with H.264 data partitioning (DP) method, we determine the decoding configurations that yield minimum energy consumption for pre-specified image qualities at the receiver. The synthesis result of this scalable MIMO detector using a 45nm technology library yields 52%, 57%, and 58% energy reductions at 24dB SNR in Foreman, Akiyo, and Mobile test streams respectively. The tradeoff is negligible 0.3dB degradation in peak signal to noise ratio (PSNR) typically used in an image quality estimation.
Synergistic Coding by Cortical Neural Ensembles

An essential step towards understanding how the brain orchestrates information processing at the cellular and population levels is to simultaneously observe the spiking activity of cortical neurons that mediate perception, learning, and motor processing. In this paper, we formulate an information theoretic approach to determine whether cooperation among neurons may constitute a governing mechanism of information processing when encoding external covariates. Specifically, we show that conditional independence between neuronal outputs may not provide an optimal encoding strategy when the firing probability of a neuron depends on the history of firing of other neurons connected to it. Rather, cooperation among neurons can provide a ?message-passing? mechanism that preserves most of the information in the covariates under specific constraints governing their connectivity structure. Using a biologically plausible statistical learning model, we demonstrate the performance of the proposed approach in synergistically encoding a motor task using a subset of neurons drawn randomly from a large population. We demonstrate its superiority in approximating the joint density of the population from limited data compared to a statistically independent model and a pairwise maximum entropy (MaxEnt) model.
Archetypal Identity Development, Meaning in Life, and Life Satisfaction: Differences Among Clinical Mental Health Counselors, School Counselors, and Counselor Educators

Adults pursuing careers in counselor education, clinical mental health counseling, and counselor education (N = 256) participated in a study that examined relationships among archetypal identity development, meaning in life, and life satisfaction. Significant differences between groups existed for 5 archetypal identities, and meaning in life was significantly related to life satisfaction.
The Usefulness of Cell Surface Markers in Predicting the Prognosis of Non-Hodgkin's Lymphomas

AbstractThe Working Formulation for classification of non-Hodgkin's lymphomas provides useful prognostic information. Since this scheme was published in 1982, many studies have investigated the prognostic significance of various cell surface markers in lymphoma cases. This article reviews the value of distinguishing T cells from B cells, CDS+ B cells, immunoglobulin light chain types, proliferation antigens such as Ki 67, other markers of B-cell differentiation, and chromosomal anomalies. Each of these contributes some further prognostic significance to that already determined by the Working Formulation.
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mTORC1 in Paneth cells, but not ISCs, and forced activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects of the niche. Finally, increased expression of bone stromal antigen 1 (Bst1) in Paneth cells—an ectoenzyme that produces the paracrine factor cyclic ADP ribose—mediates the effects of calorie restriction and rapamycin on ISC function. Our findings establish that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of the mammalian intestinal niche in coupling stem-cell function to organismal physiology.
Burn-Center Quality Improvement: Are Burn Outcomes Dependent On Admitting Facilities and Is There a Volume-Outcome “Sweet-Spot”?

Risk factors of mortality in burn patients such as inhalation injury, patient age, and percent of total body surface area (%TBSA) burned have been identified in previous publications. However, little is known about the variability of mortality outcomes between burn centers and whether the admitting facilities or facility volumes can be recognized as predictors of mortality. De-identified data from 87,665 acute burn observations obtained from the National Burn Repository between 2003 and 2007 were used to estimate a multivariable logistic regression model that could predict patient mortality with reference to the admitting burn facility/facility volume, adjusted for differences in age, inhalation injury, %TBSA burned, and an additional factor, percent full thickness burn (%FTB). As previously reported, all three covariates (%TBSA burned, inhalation injury, and age) were found to be highly statistically significant risk factors of mortality in burn patients (P value < 0.0001). The additional variable, %FTB, was also found to be a statistically significant determinant, although it did not greatly improve the multivariable model. The treatment/admitting facility was found to be an independent mortality predictor, with certain hospitals having increased odds of death and others showing a protective effect (decreased odds ratio). Hospitals with high burn volumes had the highest risk of mortality. Mortality outcomes of patients with similar risk factors (%TBSA burned, inhalation injury, age, and %FTB) are significantly affected by the treating facility and their admission volumes.
Fluid-flow analysis of TCP Westwood with RED

This paper concerns TCP Westwood (TCPW), a recently developed modification of TCP, in combination with RED queue management. We develop a fluid-flow model of TCPW with RED and use it to study both equilibrium and dynamic features. On the equilibrium side, we identify the scaling of window with loss-probability, and compare it to TCP NewReno. We also use the model to find the boundary of stability, beyond which we see large oscillations; we find that the stable region of TCPW is enhanced with respect to TCP NewReno. Furthermore we show preliminary evidence that oscillations, when they occur, have a limited impact on network throughput. Fairness and friendliness of TCPW is also analyzed and compared with NewReno. Our results show that TCPW is more fair than NewReno for flows with heterogenous round trip time. We also found that TCPW friendliness to NewReno is dependent on the difference between equilibrium queue size and the product of bandwidth and delay.
Are Immigrant Youth Faring Better in U.S. Schools?1

In spite of the growing numbers and geographic dispersion of foreign-born children, the school outcomes of foreign-born teens improved during the 1990s. Analysis of Decennial Census data reveals that fewer immigrant youth dropped out of school and their English language proficiency improved. Some of the improvement is due to compositional change in the foreign-born teen population. Levels of parental education increased over the decade. Poverty among foreign-born adolescents declined. Other youth background characteristics did not change in a favorable direction. Multivariate analysis reveals that there was a large decline in the likelihood of immigrant teens dropping out of school above and beyond the demographic changes over the decade. For example, the likelihood that a Mexican-born teen educated in U.S. schools drops out of school declined by an estimated 43 percent over the 1990s. There is little evidence, however, that U.S. schools have improved in their English language instruction over the decade.
Extremum seeking control of tunable thermoacoustic cooler

The performance of a prototype standing wave thermoacoustic cooler is optimized using an extremum seeking control algorithm. A tunable Helmholtz resonator was developed for a thermoacoustic cooler to change the boundary condition of the standing wave tube. The volume of the resonator is adjusted by changing the location of a piston on a ball-screw assembly driven by a DC motor. Multi-parameter extremum seeking control (ESC) was applied to optimize the cooling power via tuning of both the boundary condition (piston location) and the driving frequency. Experiments were conducted under both fixed and varying operating conditions. The experimental results demonstrated the effectiveness of ESC.
Temperature-modulated Alternative Splicing and Promoter Use in the Circadian Clock Gene frequency

The expression of FREQUENCY, a central component of the circadian clock in Neurospora crassa, shows daily cycles that are exquisitely sensitive to the environment. Two forms of FRQ that differ in l...
New results for linear, time-varying, discrete-time systems

An exact time-varying eigenvalue theory for continuous-time, linear time-varying dynamical systems is studied. Previous results have provided important tools for the analysis, stability characterization and synthesis of continuous time-varying systems. The authors extend their previous (1990) continuous-time results to the class of linear discrete-time systems. By this means they obtain an exact time-varying eigenvalue theory for linear, time-varying discrete-time systems. These results lead to important tools for analyzing stability and designing control laws for digital computer controlled time-varying systems. >
In vivo hyperspectral confocal fluorescence imaging to determine pigment localization and distribution in cyanobacterial cells

Hyperspectral confocal fluorescence imaging provides the opportunity to obtain individual fluorescence emission spectra in small (≈0.03-μm3) volumes. Using multivariate curve resolution, individual fluorescence components can be resolved, and their intensities can be calculated. Here we localize, in vivo, photosynthesis-related pigments (chlorophylls, phycobilins, and carotenoids) in wild-type and mutant cells of the cyanobacterium Synechocystis sp. PCC 6803. Cells were excited at 488 nm, exciting primarily phycobilins and carotenoids. Fluorescence from phycocyanin, allophycocyanin, allophycocyanin-B/terminal emitter, and chlorophyll a was resolved. Moreover, resonance-enhanced Raman signals and very weak fluorescence from carotenoids were observed. Phycobilin emission was most intense along the periphery of the cell whereas chlorophyll fluorescence was distributed more evenly throughout the cell, suggesting that fluorescing phycobilisomes are more prevalent along the outer thylakoids. Carotenoids were prevalent in the cell wall and also were present in thylakoids. Two chlorophyll fluorescence components were resolved: the short-wavelength component originates primarily from photosystem II and is most intense near the periphery of the cell; and the long-wavelength component that is attributed to photosystem I because it disappears in mutants lacking this photosystem is of higher relative intensity toward the inner rings of the thylakoids. Together, the results suggest compositional heterogeneity between thylakoid rings, with the inner thylakoids enriched in photosystem I. In cells depleted in chlorophyll, the amount of both chlorophyll emission components was decreased, confirming the accuracy of the spectral assignments. These results show that hyperspectral fluorescence imaging can provide unique information regarding pigment organization and localization in the cell.
Model Driven Data Warehousing for Business Performance Management

Traditional data warehouses are manually designed starting from specific requirements and anticipated data analysis needs. As a result there is frequently a disconnect between business process models, business definition of data artifacts and the data stored in the data warehouses as they are often designed manually and in isolation. Hence it has always been a challenge to keep the data warehouse in sync with the continuously changing business process models, resulting in both high maintenance costs and lost opportunities. In this paper we present our Model Driven Data Warehousing (MDDW) approach in the area of Business Performance Management (BPM). The purpose of MDDW is to bridge the gap between the business process models and the data warehouse models, thus enable the rapid adaptation to changes in the business environment. We describe our modeling framework comprising the various modeling elements and meta-models that capture both business and IT data artifacts.
Characterization of Patients who Suffer Asthma Exacerbations using Data Extracted from Electronic Medical Records

The increasing availability of electronic medical records offers opportunities to better characterize patient populations and create predictive tools to individualize health care. We determined which asthma patients suffer exacerbations using data extracted from electronic medical records of the Partners Healthcare System using Natural Language Processing tools from the “Informatics for Integrating Biology to the Bedside” center (i2b2). Univariable and multivariable analysis of data for 11,356 patients (1,394 cases, 9,962 controls) found that race, BMI, smoking history, and age at initial observation are predictors of asthma exacerbations. The area under the receiver operating characteristic curve (AUROC) corresponding to prediction of exacerbations in an independent group of 1,436 asthma patients (106 cases, 1,330 controls) is 0.67. Our findings are consistent with previous characterizations of asthma patients in epidemiological studies, and demonstrate that data extracted by natural language processing from electronic medical records is suitable for the characterization of patient populations.
Solution structure of a yeast ubiquitin‐like protein Smt3: The role of structurally less defined sequences in protein–protein recognitions

Smt3 belongs to a growing family of ubiquitin-related proteins involved in posttranslational protein modification. Independent studies demonstrate an essential function of Smt3 in the regulation of nucleocytoplasmic transport, and suggest a role in cell-cycle regulation. Here we report the high-resolution NMR structure of yeast Smt3 in the complex free form. Our comparison of the Smt3 NMR structure with the Smt3 crystal structure in complex with the C-Terminal Ulp1 protease domain revealed large structural differences in the binding surface, which is also involved in the Smt3-Ubc-9 interaction detected by NMR. The structural differences in the region indicate the important functions of conserved residues in less structurally defined sequences.
The Organization Man in the Presidency

QN SEPTEMBER 24, 1957 President Eisenhower made a nationwide radio-television talk to explain his drastic action in the school integration crisis at Little Rock, Arkansas. But no one reading the news accounts of the second fortnight in September could suppose that the President himself had played a significant role in this historic policy-making. The decision to federalize theArkansas National Guard and to send federal troops to Little Rock was a White House decision. The President was on vacation in Newport, Rhode Island. The "cease and desist" order to the mob in Little Rock was read by James Hagerty, the President's Press Secretary, to the reporters in Newport on the evening of September 23rd. It is unlikely that the President had any part in the writing of the order which appeared above his initials. It was probably drafted for him while he was en route from Washington to Newport earlier in the day. That morning he had been in Washington on other business but even while tension turned to violence in Little Rock, the President had flown back to Newport. So eager was he to get back to the golf links that he went directly from helicopter to limousine to yacht without bothering to stop at the "summer White House." While he was busy changing into golf togs on the yacht, Attorney General Brownell was trying to intercept him by long distance from Washington. What was said over the telephone when the connection was finally made we do not know, but the President did not reach the golf course that afternoon. Meantime, in Washington, Army Secretary Wilbur Brucker and the Attorney General were in close consultation with each other. September 24th, shortly after noon, the President signed the executive order directing the Secretary of Defense to call the Arkansas National Guard into active service and to employ federal troops to execute the federal court orders in Little Rock. Late that
NK/T-cell non-Hodgkin's lymphoma with secondary haemophagocytic lymphohistiocytosis treated with matched unrelated donor allogeneic stem cell transplant

A 39-year-old Hispanic man who was recently diagnosed with stage IV NK/T-cell lymphoma nasal type from paratracheal lymph node and bone marrow biopsy (figures 1 and 2) presented to the emergency department with fever, chills and general weakness for 2 weeks. The patient was tachycardic, tachypneic and hypotensive. Physical examination showed marked hepatosplenomegaly and complete blood count revealed pancytopaenia. Liver function test demonstrated total bilirubin 19.1 mg/dL, asparate aminotransferace 144 IU/L, alamine transaminase 92 IU/L, alkaline phosphatase 595 IU/L and fibrinogen 54 mg/dL (figure 3). Iron panel revealed iron 203 μg/dL, serum ferritin 48 900 ng/mL and transferrin saturation 94%. Subsequent positron emission tomography (PET) and MRI demonstrated marked hepatosplenomegaly and multiple mediastinal and retroperitoneal lymph node enlargement with avid fluorodeoxyglucose update (figure 4), meeting the diagnostic criteria of haemophagocytic lymphohistiocytosis (HLH; table 1).1 View this table: Table 1 Diagnostic criteria of HLH1 Figure 1 Paratracheal lymph node biopsy showing diffuse infiltration by large atypical cells with coarse chromatin, prominent nucleoli and abundant eosinophilic cytoplasm intermixed with a smaller number of small mature lymphocytes and histiocytes (A and B). Apoptotic bodies and numerous mitotic figures …
Design of a Dual-Band, Compact Yagi Antenna Over an EBG Ground Plane

A two-element, closely spaced, compact Yagi antenna over an electromagnetic bandgap (EBG) ground plane was designed to provide dual bands. The lower band is generated by the driver element of the Yagi over the EBG ground plane out of the reflection phase band (driver mode). The higher band is attained due to the overall Yagi over the EBG ground plane in the reflection phase band (Yagi mode). The measured realized gains toward the director direction in the driver and Yagi modes are 6.6 and 8.0 dB, respectively.
Dissociation between neonatal novelty-induced preferential maternal care and enhancement in cognitive, social, and emotional functions

Early life stimulation is known to produce long-lasting changes in the brain and behavior. One such early stimulation method is the neonatal novelty exposure procedure which allows the isolation of the novelty effect from several prominent confounding factors inherent to the neonatal handling procedure. In two previous studies, we found long-lasting novelty effects on different sets of functional measures without accompanying preferential maternal care, even when the observation was made immediately after the novelty manipulation, a time when such preferential care is most likely to be expressed. Here, within a single cohort of Long-Evans male rats, we demonstrate that novelty exposure leads to enhancements across several functional domains, including increased disinhibition to novelty, enhanced spatial and social memory, and reduced aggression, again without the accompaniment of preferential maternal care. These findings extend novelty exposure effects to aggression and replicate previously known novelty exposure effects on spatial and social memory with extension to new developmental stages. Most importantly, these findings do not support the hypothesis that preferential maternal care towards novelty-exposed pups mediates the observed novelty effects. We discuss the possibility that the effects of neonatal novelty exposure are mediated via repeated activation of the hypothalamic-pituitary-adrenal (HPA) axis that serves to inoculate pups for future exposures to novelty and novelty-induced HPA activation and that maternal influence is likely to be expressed via its modulatory role-the mother sets the individual-family specific behavioral and hormonal context to allow the same early life experience to have a family-specific effect.
Interior Design Practitioner Motivations for Specifying Sustainable Materials: Applying the Theory of Planned Behavior to Residential Design

Although sustainable design has become one of the major concerns in the interior design industry, the frequency of making such sustainable choices in real practice is still limited. Given that little research has yet focused on interior designers' choice of sustainable material, this study aimed to identify factors affecting interior designers' sustainable material choices focusing on sustainable flooring materials for residential use. On the basis of the Theory of Planned Behavior (TPB) as a theoretical framework, we developed hypotheses to test relationships (1) between three determinants (attitude, subjective norm, and perceived behavioral control) and behavioral intention and (2) between two behavioral beliefs (environmental outcome and health outcome) and attitude. This study used quantitative methodologies through an Internet survey with a sample selected from American Society of Interior Designers practicing residential design. A total of 225 final surveys were utilized for further analysis. Findings revealed that all three determinants (attitude, subjective norms, and perceived behavioral control) were positively associated with behavioral intention to choose sustainable flooring materials. Attitude toward adopting sustainable flooring materials were significantly related to environmental beliefs but not to health beliefs. Our findings imply that the TPB framework can provide valuable insights for developing more effective and comprehensive strategies and strengthening the interior design curriculum to promote interior designers' sustainable decision-making in material choices in actual real-life design practice.
Spontaneous coronary artery dissection following a preeclampsia pregnancy

1. IntroductionSpontaneous coronary artery dissection (SCAD) is an uncommoncause of acute myocardial infarction. The dissection of tunica intima ormedia,formingofhematomaunderneatharterialwallandcompressingthe true coronary lumen leads to myocardial infarction of distal cardiactissue. Thehigh suspiciousindexshouldmakein young female withoutany cardiovascular risk, especially in peripartum period. Emergent cor-onaryangiogramfollowedbyintravascularultrasoundisrecommendedfor diagnosis; however optimal treatment is still inconclusive [1].
Abl Family Kinases Regulate FcγR-Mediated Phagocytosis in Murine Macrophages

Phagocytosis of Ab-coated pathogens is mediated through FcγRs, which activate intracellular signaling pathways to drive actin cytoskeletal rearrangements. Abl and Arg define a family of nonreceptor tyrosine kinases that regulate actin-dependent processes in a variety of cell types, including those important in the adaptive immune response. Using pharmacological inhibition as well as dominant negative and knockout approaches, we demonstrate a role for the Abl family kinases in phagocytosis by macrophages and define a mechanism whereby Abl kinases regulate this process. Bone marrow-derived macrophages from mice lacking Abl and Arg kinases exhibit inefficient phagocytosis of sheep erythrocytes and zymosan particles. Treatment with the Abl kinase inhibitors imatinib and GNF-2 or overexpression of kinase-inactive forms of the Abl family kinases also impairs particle internalization in murine macrophages, indicating Abl kinase activity is required for efficient phagocytosis. Further, Arg kinase is present at the phagocytic cup, and Abl family kinases are activated by FcγR engagement. The regulation of phagocytosis by Abl family kinases is mediated in part by the spleen tyrosine kinase (Syk). Loss of Abl and Arg expression or treatment with Abl inhibitors reduced Syk phosphorylation in response to FcγR ligation. The link between Abl family kinases and Syk may be direct, as purified Arg kinase phosphorylates Syk in vitro. Further, overexpression of membrane-targeted Syk in cells treated with Abl kinase inhibitors partially rescues the impairment in phagocytosis. Together, these findings reveal that Abl family kinases control the efficiency of phagocytosis in part through the regulation of Syk function.
Identifying Infants and Toddlers at High Risk for Persistent Delays

Objectives Little is known about the extent to which a developmental delay identified in infancy persists into early childhood. This study examined the persistence of developmental delays in a large nationally representative sample of infants and toddlers who did not receive early intervention. Methods In a sample (n ≈ 8700) derived from the early childhood longitudinal study, birth cohort, we examined developmental changes between 9 and 24 months. Motor and cognitive delays were categorized as none, mild, and moderate/severe. Adjusted ordinal logistic regression models estimated the likelihood of worse developmental delay at 24 months. Results About 24 % of children had a cognitive delay and 27 % had a motor delay at either 9- or 24-months. About 77 % of children with mild and 70 % of children with moderate/severe cognitive or motor developmental delay at 9-months had no delay at 24-months. Children with mild cognitive delay at 9-months had 2.4 times the odds of having worse cognitive function at 24-months compared to children with no cognitive delay at 9 months. Children with moderate/severe cognitive delay at 9-months had three times the odds of having worse cognitive abilities at 24-months than children who had no cognitive delay at 9-months. Similar results were found for motor skills. Conclusions Developmental delays in infants are changeable, often resolving without treatment. This work provides knowledge about baseline trajectories of infants without and without cognitive and motor delays. It documents the proportion of children’s delays that are likely to be outgrown without EI and the rate at which typically-developing infants are likely to display developmental delays at 2-years of age.
Persistence of Native Values: The Inquisition and the Indians of Colonial Mexico

The Holy Office of the Inquisition in colonial Mexico had as its purpose the defense of Spanish religion and Spanish-Catholic culture against individuals who held heretical views and people who showed lack of respect for religious principles. Inquisition trials of Indians suggest that a prime concern of the Mexican Church in the sixteenth century was recurrent idolatry and religious syncretism. During the remainder of the colonial period and until 1818, the Holy Office of the Inquisition continued to investigate Indian transgressions against orthodoxy as well as provide the modern researcher with unique documentation for the study of mixture of religious beliefs. The “procesos de indios” and other subsidiary documentation from Inquisition archives present crucial data for the ethnologist and ethnohistorian, preserving a view of native religion at the time of Spanish contact, eyewitness accounts of post-conquest idolatry and sacrifice, burial rites, native dances and ceremonies as well as data on genealogy, social organization, political intrigues, and cultural dislocation as the Iberian and Mesoamerican civilizations collided. As “culture shock” continued to reverberate across the seventeenth and eighteenth centuries, Inquisition manuscripts reveal the extent of Indian resistance or accommodation to Spanish Catholic culture.
Hydrogen Bonding and OH-Stretch Spectroscopy in Water: Hexamer (Cage), Liquid Surface, Liquid, and Ice

We present a unified picture of how OH-stretch spectroscopy in water can be understood in terms of hydrogen bonding for the four systems listed in the title. To understand the strength, and hence OH-stretch frequency, of a hydrogen bond, it is crucial to consider the number of additional acceptor hydrogen bonds made by both the donor and acceptor molecules. This necessity for focusing on the hydrogen-bond environment of both donor and acceptor molecules follows from quantum chemical considerations and is related to the three-body interactions in water. Armed with this understanding we can make a detailed interpretation of the OH-stretch IR absorption spectrum of the cage conformer for HOD(D2O)5 and the imaginary part of the ssp OH-stretch sum-frequency spectrum of the surface of liquid D2O with dilute HOD.
Probability learning and the blank trials law

This experiment supported and generalized a theorem relating outcome and nonoutcome performance derived from a hypothesis model for 2-choice discrimination learning in adult human Ss. The verified prediction was that Ss behave the same when E says nothing as when E says “right” to every response. This conclusion holds even for sequences of 20 responses and for probability learning tasks.
Chick Embryo Development Rate in Response to Light Stimulus

Abstract Crossbred and purebred embryos in brown- and white-shelled eggs were incubated under light and dark treatments. Embryos developed under lights were significantly (P ≤ .01) larger than those developed under dark conditions at 15 days of incubation. The rates of weight increase over days accelerated differentially in the two treatments, but treatment effects were not altered by shell color or breed of parents. Hatching time of illuminated embryos was significantly (P ≤ .01) reduced by an average of 5 hours.
The Synthesis, Identification, and Kinetic Characterization of the Photoaffinity Label: 3-Azidopyridine Adenosine Dinucleotide: An Advanced Undergraduate Laboratory Experiment Appropriate for Organic, Biochemistry, or Bio-organic Chemistry

We present here a complete photochemical experiment suitable for biochemistry, bioorganic, and organic chemistry laboratories. It provides experiences in chemical and enzymatic syntheses, spectroscopy (IR, NMR, UV), chromatography (TLC, GC-MS), and a simple enzyme kinetic study utilizing UV spectroscopy. The application of light energy to produce chemical changes has recently expanded beyond photography, lithography, and organic synthesis to include use in tumor phototherapy [1] and as antiviral agents [2]. Dyes and a variety of photoactive chemicals have demonstrated potential use as environmentally benign insecticides, herbicides, and fungicides [3, 4]. Nevertheless, the traditional undergraduate chemical laboratory curriculum provides little exposure to photochemistry.
Negotiating nation: Native participation in the cartographic construction of the Trans-Mississippi West:

Since the 1970s, historians of cartography have resituated the map as a form of discourse that contains power, rhetoric, and value. Unlike the critical investigations into Euro-American maps, howev...
Acute bouts of exercise induce a suppressive effect on lymphocyte proliferation in human subjects: A meta-analysis.

Abstract Objective Lymphocyte proliferative responses are commonly used to assess immune function in clinical settings, yet it is unclear how proliferative capacity is altered by exercise. This analysis aims to quantitatively assess the proliferative response of lymphocytes following an acute bout of exercise. Methods Electronic databases were searched for articles containing the keywords “exercise” OR “acute” OR “aerobic” OR “resistance training” OR “immune function” AND “proliferation” AND “lymphocyte.” Initial results yielded 517 articles of which 117 were reviewed in full. Twenty-four articles met the inclusion criteria. Calculated standardized mean difference (SMD) and corresponding standard errors (SE) were integrated using random-effect models. Results Analyses uncovered evidence for suppression of proliferative capacity following acute exercise in general (SMD = −0.18, 95% CI: −0.21, −0.16) with long duration, high intensity exercise exhibiting a moderate suppressive effect (SMD = −0.55, 95% CI: −0.86, −0.24). Discordant proliferative responses for long duration, high intensity exercise in competitive versus non-competitive settings were identified with enhanced proliferation (SMD = 0.46, 95% CI: 0.03, 0.89) observed following competitive events and a large suppressive effect detected for similar activities outside of a competitive environment (SMD: −1.28, 95% CI: −1.61, −0.96) (p = 0.02). Conclusion Evidence suggests lymphocyte proliferation is suppressed following acute bouts of exercise, with exercise lasting longer than one hour having a greater magnitude of effect regardless of exercise intensity. Variations in observed effect sizes across intensity, duration, and competitive environment further highlight our need to acknowledge the impact of study designs in advancing our understanding of exercise immunology.
Transureteroureterostomy and Terminal Loop Cutaneous Ureterostomy in Advanced Pelvic Malignancies

AbstractTransureteroureterostomy was combined with terminal loop cutaneous ureterostomy, without complications, in 8 patients with advanced pelvic malignancy and a poor prognosis. Urinary diversion was palliative in all patients and followed pelvic exenteration in 4, debulking of pelvic tumor in 2 and radical cystectomy in 1, while 1 had inoperable bladder cancer. All patients had at least unilateral hydroureteronephrosis preoperatively. In each case a postoperative excretory urogram revealed significant improvement of the hydroureteronephrosis and the serum creatinine improved or stabilized. No patient had ureteral stomal stenosis or retraction. Mean survival was 5 months, with the longest survival being 1 year. Transureteroureterostomy in conjunction with terminal loop cutaneous ureterostomy is an effective technique of urinary diversion in selected patients with a poor prognosis and advanced pelvic malignancy, decreasing operative time while avoiding the morbidity associated with a ureterointestinal op...
Oefentherapie bij chronische vermoeidheid

Context Het chronisch vermoeidheidssyndroom (CVS) bestaat uit onverklaarbare persisterende vermoeidheid met daarnaast ook andere klachten, zoals musculoskeletale pijn of slaapproblemen. De multidisciplinaire richtlijn CVS adviseert cognitieve gedragstherapie (CGT) als eerste behandeloptie. Oefentherapie wordt echter ook genoemd als een mogelijke behandelvorm.
“Playing the away game”: AFRICOM in the Sahara-Sahel

Abstract This article presents evidence to revise hypotheses of how biopolitical strategies are deployed in contemporary global security regimes, and with what effects. It is based on research into the US military's Africa Command (AFRICOM). Elaborating on two concepts that Michel Foucault hypothesized in his Security, Territory, Population lectures –the “people” and the “milieu” –I argue that AFRICOM's strategy is informed by biopolitical rationalities, but that this does not necessarily situate African populations as either part of a population to secure or as a threat to that population. Instead, I suggest that (unlike in the urban and national contexts that Foucault analyzed) biopolitical security strategies at the global scale are characterized by varying degrees of distance between the way(s) of life they aim to defend and what Foucault termed the “field of intervention” or “milieu” that they target. This hypothesis, and its elaboration through the case of AFRICOM, contributes to efforts to historicize and spatialize accounts of contemporary biopolitics. Specifically, it suggests that we can better understand the production of very uneven geographies of security and insecurity by attending to the relationships between the ways of life being secured and the (potentially distant) material contexts situated as relevant “fields of intervention”.
Expectations, Taylor Rules and Liquidity Traps

This paper includes three equilibrium paths (Christiano et al . 2011; Werning 2012; Cochrane 2016) that model liquidity traps in a unified framework with expectations of duration of the zero lower bound and expectations of a Taylor-type rule outside of the trap, and finds that their appearance depends on these expectations. Other than that, Werning (2012)’s and Cochrane (2016)’s equilibrium paths require one more strong assumption and are thus arguably harder to observe in reality although Cochrane (2016)’s equilibrium path fits the recent data better.
Distribution of western juniper seeds across an ecotone and implications for dispersal

Abstract. Western juniper woodlands have been the focus of extensive research and management due to range expansion and infilling that began over a century ago. Understanding juniper seed dispersal is vital to identifying processes behind this expansion. Dispersal of Juniperus seeds has generally been attributed to consumption of female juniper cones (“berries”) by frugivorous birds and mammals, which then defecate seeds after gut passage. However, recent studies have found that scatter-hoarding rodents harvest and cache juniper seeds. Rodents caching and failing to recover juniper seeds that have been removed from feces may constitute a secondary mode of dispersal that accounts for more seedling recruitment than primary dispersal by frugivores. We considered implications of juniper seed dispersal by frugivorous birds and subsequent removal of bird-passed seeds and secondary dispersal by scatter-hoarding rodents by examining the distribution of western juniper seeds after dispersal by birds along transect...
Rapid Detection of γ-H2Av Foci in Ex Vivo MMS-Treated Drosophila Imaginal Discs

In Drosophila melanogaster, DNA double-strand breaks (DSBs) created by exposure to gamma or X-ray radiation can be quantified by immunofluorescent detection of phosphorylated histone H2Av (γ-H2Av) foci in imaginal disc tissues. This technique has been less useful for studying DSBs in imaginal discs exposed to DSB-inducing chemicals, since standard protocols require raising larvae in food treated with liquid chemical suspensions. These protocols typically take 3-4 days to complete and result in heterogeneous responses that do not provide information about the kinetics of DSB formation and repair. Here, we describe a novel and rapid method to quantify DSBs in imaginal discs cultured ex vivo with methyl methanesulfonate (MMS) or other DSB-inducing chemicals. The described method requires less than 24 h and provides precise control over MMS concentration and exposure time, enabling reproducible detection of transient DSBs. Furthermore, this technique can be used for nearly any chemical treatment and can be modified and adapted for several different experimental setups and downstream molecular analyses.