cssi/SciSciGPT-SciSciNet huggingface dataset:
Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator–Heme Oxygenase-1 Circuits

Resolution of acute inflammation is an active event accompanied by biosynthesis of specialized proresolving mediators (SPM). We employed a systems approach to determine the impact of CO in resolution active programs during self-limited inflammation in mice. Compared with ambient air, inhaled CO gas (250 ppm) significantly limited PMN infiltration (∼44%, 6 h) into peritoneum and shortened resolution interval from 4 to 2 h. We profiled exudate lipid mediators (LM) via metabololipidomics, CO reduced leukotriene B4 (21 ± 11 versus 59 ± 24 pg/mouse, 6 h), and elevated SPM including resolvin (Rv) D1 (27 ± 4 versus 16 ± 5 pg/mouse) and maresin 1 (26 ± 9 versus 15 ± 3 pg/mouse). With human macrophages, SPM (10 pM-10 nM) elevated heme oxygenase (HO)-1 (∼50%, 8 h). CO also enhanced HO-1 expression and accumulation of RvD1 and RvD5, an action reversed by blockage of a key SPM biosynthesis enzyme 15-lipoxygenase type 1. Compared with normoxia, CO increased ∼30% phagocytosis of opsonized zymosan with human macrophage, which was further enhanced by SPM (∼100%). This CO increased phagocytosis was blocked by 15-lipoxygenase inhibition, and SPM stimulated phagocytosis was diminished by HO-1 inhibition. In murine peritonitis, both pre- and posttreatment with CO inhalation significantly increased macrophages carrying ingested apoptotic PMN in exudates and enhanced PMN apoptosis. Taken together, these results indicate that CO accelerates resolution of acute inflammation, shortens resolution intervals, enhances macrophage efferocytosis, and temporally regulates local levels of lipid mediator/SPM. Moreover, they provide proresolving mechanisms for HO-1/CO, which is part of the SPM-initiated resolution circuit.
Adaptive Parallel Graph Mining for CMP Architectures

Mining graph data is an increasingly popular challenge, which has practical applications in many areas, including molecular substructure discovery, web link analysis, fraud detection, and social network analysis. The problem statement is to enumerate all subgraphs occurring in at least \sigma graphs of a database, where \sigma is a user specified parameter. Chip Multiprocessors (CMPs) provide true parallel processing, and are expected to become the de facto standard for commodity computing. In this work, building on the state-of-the-art, we propose an efficient approach to parallelize such algorithms for CMPs. We show that an algorithm which adapts its behavior based on the runtime state of the system can improve system utilization and lower execution times. Most notably, we incorporate dynamic state management to allow memory consumption to vary based on availability. We evaluate our techniques on current day shared memory systems (SMPs) and expect similar performance for CMPs. We demonstrate excellent speedup, 27- fold on 32 processors for several real world datasets. Additionally, we show our dynamic techniques afford this scalability while consuming up to 35% less memory than static techniques.
WS-Naming: location migration, replication, and failure transparency support for Web Services

Naming transparencies, i.e. abstracting the name and binding of the entity being used from the endpoints that are actually doing the work, are used in distributed systems to simplify application development by hiding the complexity of the environment. In this paper, we demonstrate how to apply traditional distributed systems naming and binding techniques in the Web Services realm. Specifically, we show how the WS-Naming profile on WS-Addressing Endpoint References can be used for identity, transparent failover, replication, and migration. We begin with a discussion of the traditional distributed systems transparencies. We then present four detailed use cases. Next, we provide a brief background on both WS-Addressing and WS-Naming. Finally, we show how WS-Naming can be used to provide transparent implementations of our use cases. Copyright © 2009 John Wiley & Sons, Ltd.
Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis

The endosomal compartment of polarized epithelial cells is a major crossroads for membrane traffic. Proteins entering this compartment from the cell surface are sorted for transport to one of several destinations: recycling to the original cell surface, targeting to lysosomes for degradation, or transcytosis to the opposite surface. The polymeric immunoglobulin receptor (pIgR), which is normally transcytosed from the basolateral to the apical surface, was used as a model to dissect the signals that mediate this sorting event. When exogenous receptor was expressed in Madin-Darby Canine Kidney (MDCK) cells, it was shown that phosphorylation of pIgR at the serine residue at position 664 is required for efficient transcytosis. Replacement of this serine with alanine generated a receptor that is transcytosed only slowly, and appears to be recycled. Conversely, substitution with aspartic acid (which mimics the negative charge of the phosphate group) results in rapid transcytosis. It was concluded that phosphorylation is the signal that directs the pIgR from the endosome into the transcytotic pathway.
T Cell Responses During Human Immunodeficiency Virus (HIV)-1 Infection

The defining features of the acquired immunodeficiency are the “­persistent and profound selective decrease in the function as well as number of T lymphocytes of the helper/inducer subset and a possible activation of the suppressor/cytotoxic subset”, as described in 1982 (Mildvan, D., U. Mathur, et al. (1982). “Opportunistic infections and immune deficiency in homosexual men.” Ann Intern Med 96(6 Pt 1): 700–4). Nowadays, although depletion of CD4+ T-cells remains a hallmark of Human Immunodeficiency Virus (HIV) infection, the multifactorial nature of the disease provoked by infection by HIV-1 or Simian Immunodeficiency Virus (SIV) in “non-natural” hosts is generally acknowledged, in that no unique immune alteration has been identified that can fully explain the plethora of dysregulation associated with the development of pathogenic HIV and SIV infection.
Information-theoretic limits of graphical model selection in high dimensions

The problem of graphical model selection is to correctly estimate the graph structure of a Markov random field given samples from the underlying distribution. We analyze the information-theoretic limitations of this problem under high-dimensional scaling, in which the graph size p and the number of edges k (or the maximum degree d) are allowed to increase to infinity as a function of the sample size n. For pairwise binary Markov random fields, we derive both necessary and sufficient conditions on the scaling of the triplet (n, p, k) (or the triplet (n, p, d)) for asympotically reliable reocovery of the graph structure.
Social Historical Studies of Women, Crime, and Courts

While traditional criminology has ignored the historical dimension of female crime, social historical literature has examined the interplay between gender and the criminal process in a variety of historical settings. This review examines studies focusing on changes in crime, prosecution, conviction, and punishment patterns over time, as well as studies in particular settings. From these studies we conclude that crime has not always been a predominantly male phenomenon and that female crime rates have changed over time. We also conclude that, within the different categories, women defendants in particular were perceived through a gendered perspective, and their criminalization and punishment, as well as its representation in popular culture, reflected this special perspective.
Stochastic methods in engineering design

Frequently, problems encountered in engineering design deal with finding an optimal solution to problems that are of a stochastic nature. The fundamental problem of optimization is to arrive at the best possible decision in any given set of circumstances. The first step, therefore in a mathematical optimization problem is to choose some quantity, typically a function of several variables, to be maximized or minimized, subject possibly to one or more constraints. The most common types of constraint are equalities and inequalities which must be satisfied by the variables of the problem, but many other types of constraint are possible; for example, a solution in integers may be required. The next step is to choose a mathematical method to solve the optimization problem; such methods are usually called optimization techniques, or algorithms. The author discusses combinatorial optimization, optimization methods (calculus based methods, enumerative methods and random methods) and randomised techniques (simulated annealing and genetic algorithms).
NHERF1 regulation of PTH-dependent bimodal Pi transport in osteoblasts

Abstract Control of systemic inorganic phosphate (Pi) levels is crucial for osteoid mineralization. Parathyroid hormone (PTH) mediates actions on phosphate homeostasis mostly by regulating the activity of the type 2 sodium–phosphate cotransporter (Npt2), and this action requires the PDZ protein NHERF1. Osteoblasts express Npt2 and in response to PTH enhance osteogenesis by increasing mineralized matrix. The regulation of Pi transport in osteoblasts is poorly understood. To address this gap we characterized PTH-dependent Pi transport and the role of NHERF1 in primary mouse calvarial osteoblasts. Under proliferating conditions osteoblasts express Npt2a, Npt2b, PTH receptor, and NHERF1. Npt2a mRNA expression was lower in calvarial osteoblasts from NHERF1-null mice. Under basal conditions Pi uptake in osteoblasts from wild-type mice was greater than that of knockout mice. PTH inhibited Pi uptake in proliferating osteoblasts from wild-type mice, but not in cells from knockout mice. In vitro induction of mineralization enhanced osteoblast differentiation and increased osterix and osteocalcin expression. Contrary to the results with proliferating osteoblasts, PTH increased Pi uptake and ATP secretion in differentiated osteoblasts from wild-type mice. PTH had no effect on Pi uptake or ATP release in differentiated osteoblasts from knockout mice. NHERF1 regulation of PTH-sensitive Pi uptake in proliferating osteoblasts is mediated by cAMP/PKA and PLC/PKC, while modulation of Pi uptake in differentiated osteoblasts depends only on cAMP/PKA signaling. The results suggest that NHERF1 cooperates with PTH in differentiated osteoblasts to increase matrix mineralization. We conclude that NHERF1 regulates PTH that differentially affects Na-dependent Pi transport at distinct stages of osteoblast proliferation and maturation.
SolarCore: Solar energy driven multi-core architecture power management

The global energy crisis and environmental concerns (e.g. global warming) have driven the IT community into the green computing era. Of clean, renewable energy sources, solar power is the most promising. While efforts have been made to improve the performance-per-watt, conventional architecture power management schemes incur significant solar energy loss since they are largely workload-driven and unaware of the supply-side attributes. Existing solar power harvesting techniques improve the energy utilization but increase the environmental burden and capital investment due to the inclusion of large-scale batteries. Moreover, solar power harvesting itself cannot guarantee high performance without appropriate load adaptation. To this end, we propose SolarCore, a solar energy driven, multi-core architecture power management scheme that combines maximal power provisioning control and workload run-time optimization. Using real-world meteorological data across different geographic sites and seasons, we show that SolarCore is capable of achieving the optimal operation condition (e.g. maximal power point) of solar panels autonomously under various environmental conditions with a high green energy utilization of 82% on average. We propose efficient heuristics for allocating the time varying solar power across multiple cores and our algorithm can further improve the workload performance by 10.8% compared with that of round-robin adaptation, and at least 43% compared with that of conventional fixed-power budget control. This paper makes the first step on maximally reducing the carbon footprint of computing systems through the usage of renewable energy sources. We expect that the novel joint optimization techniques proposed in this paper will contribute to building a truly sustainable, high-performance computing environment.
On the Capacity of Training-Based Transmissions with Input Peak Power Constraints

In this paper, training-based transmissions over a priori unknown Rayleigh block fading channels are considered. The input signals are assumed to be subject to peak power constraints. Prior to data transmission, channel fading coefficients are estimated in the training phase with the aid of pilot symbols. In this setting, the capacity and capacity-achieving input distribution are studied. The magnitude distribution of the optimal input is shown to be discrete with a finite number of mass points. The capacity, bit energy requirements, and optimal resource allocation strategies are obtained through numerical analysis. The bit energy is shown to grow without bound as SNR decreases to zero due to the presence of peakedness constraints. Capacity and energy-per-bit are also analyzed under the assumptions that the transmitter interleaves the data symbols before transmission over the channel, and per-symbol peak power constraints are imposed. Comparisons of the performances of training-based and noncoherent transmission schemes are provided.
Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill

New onset thrombocytopenia and multiple organ failure (TAMOF) presages poor outcome in critical illness. Patients who resolve thrombocytopenia by day 14 are more likely to survive than those who do not. Patients with TAMOF have a spectrum of microangiopathic disorders that includes thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC) and secondary thrombotic microanigiopathy (TMA). Activated protein C is effective in resolving fibrin-mediated thrombosis (DIC); however, daily plasma exchange is the therapy of choice for removing ADAMTS 13 inhibitors and replenishing ADAMTS 13 activity which in turn resolves platelet: von Willebrand Factor mediated thrombosis (TTP/secondary TMA).
Synthesis and characterization of phase-change nanowires.

Phase-change memory materials have stimulated a great deal of interest although the size-dependent behaviors have not been well studied due to the lack of method for producing their nanoscale structures. We report the synthesis and characterization of GeTe and Sb2Te3 phase-change nanowires via a vapor−liquid−solid growth mechanism. The as-grown GeTe nanowires have three different types of morphologies: single-crystalline straight and helical rhombohedral GeTe nanowires and amorphous curly GeO2 nanowires. All the Sb2Te3 nanowires are single-crystalline.
Movement Variability and the Use of Nonlinear Tools: Principles to Guide Physical Therapist Practice

Fields studying movement generation, including robotics, psychology, cognitive science, and neuroscience, utilize concepts and tools related to the pervasiveness of variability in biological systems. The concepts of variability and complexity and the nonlinear tools used to measure these concepts open new vistas for physical therapist practice and research in movement dysfunction of all types. Because mounting evidence supports the necessity of variability for health and functional movement, this perspective article argues for changes in the way therapists view variability, both in theory and in action. By providing clinical examples, as well as applying existing knowledge about complex systems, the aim of this article is to create a springboard for new directions in physical therapist research and practice.
Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas.

Summary Endometrial carcinoma is one of the most common malignancies of the female genital tract. Metastasis-associated protein 1 (MTA1) is a component of the Mi-2/nucleosome remodeling and deacetylating complex and acts as a potent corepressor of estrogen receptor in breast cancer cells. MTA1 expression has been demonstrated in various cancers but has never been explored in endometrial carcinoma. We investigated the expression profile of MTA1 in different stages of benign endometrium as well as in endometrial endometrioid adenocarcinoma using immunohistochemistry and Western blotting. In the proliferative and secretory phases, MTA1 was expressed in both the glandular and the stromal compartments and was localized in nucleus and cytoplasm of these cells. MTA1 expression in secretory phase was less prominent when compared with the proliferative phase. In postmenopausal sections, MTA1 staining was observed in both glandular and stromal compartments and was localized in both nucleus and cytoplasm. Western blot analysis of 6 tumor specimens showed increased expression of MTA1 in all the tumors analyzed. Immunohistochemical staining performed on tumor microarray containing 70 endometrial endometrioid adenocarcinomas of various grades showed increased expression of MTA1 in 53 (75.7%) tumors. In grade 1 and grade 2 tumors, MTA1 was present in both nucleus and cytoplasm. Interestingly, in grade 3 tumors, MTA1 was localized in the cytoplasm only. Our results suggest a potential role of MTA1 in endometrial carcinomas.
Static compression of iron to 78 GPa with rare gas solids as pressure-transmitting media

New data are presented for the room temperature, static compression of iron to 78 GPa with solid neon and argon as pressure-transmitting media. X ray diffraction studies have been performed on a geophysically relevant material, for the first time to such pressures under quasihydrostatic conditions, in a diamond anvil cell. The hydrostatic technique leads to increased precision in the measurement of high pressures and has placed closer constraints on the equation of state of e iron. From a linear least squares fit of a finite strain equation of state to the present data combined with earlier, low-pressure data for metastable e iron, the preferred values for the zero-pressure isothermal bulk modulus, K0, and first pressure derivative, K0′, are 192.7 (±9.0) GPa and 4.29 (±0.36), respectively. The zero-pressure volume for the e phase is 6.687 (±0.018) cm3/mol. On the basis of the pressure-volume curve calculated from fits of the finite strain equation of state, e iron appears to be less compressible under nonhydrostatic conditions, but the differences are within the error of the nonhydrostatic experiment. The results also confirm that the absence of a soft medium in static compression experiments with the diamond anvil cell results in an overestimate of the unit cell volume (measured with the incident X ray beam parallel to the load axis) for pressures calculated with the nonhydrostatic ruby calibration scale. It is found that for e iron, substantial compensation for this nonhydrostatic effect is implicit in the nonhydrostatic ruby pressure scale up to intermediate strains. The hydrostatic data and the e iron isotherm derived from shock wave experiments on iron samples are in very close agreement.
A micropower, multichannel biotelemetry system.

In order to gather biodata in the home environment, we have developed a compact and inexpensive FM multichannel subcarrier system employing micropower integrated circuits of the unique lateral PNP design. The subcarrier system may be used with or without a wireless transmitter. One FM transmitter design that has been used is presented. Components for four channels are mounted on a glass epoxy circuit board. More channels may be added and the potential for hybrid film packaging was considered in the design. Standard IRIG 7.5% proportional subcarrier frequencies from 400 Hz (ch. 1) to 3000 Hz (ch. 8) may be used with the center frequency being determined by the value of a single component in the oscillator circuit. The overall simplicity, stability, fidelity, and low power requirements of this subcarrier system facilitate long term unattended recording.
Availability analysis of composite coteries

A collection of quorums is called a coterie. The authors present an algorithm to construct coteries by composing existing coteries. The resulting coteries are called composite coteries. Several different measures may be used to analyze coteries. One of the most commonly used measures is availability. In general, it is difficult to directly compute the availability of coteries in a large system. An efficient method is described to compute the availability of composite coteries, even in a large system. >
The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion

Skeletal muscle development (myogenesis) is a complex but precisely orchestrated process involving spatiotemporal regulation of the proliferation, differentiation and fusion of myogenic progenitor cells (myoblasts). Here we identify brain expressed x-linked gene 1 (Bex1) as a transient, developmentally regulated gene involved in myoblast fusion. Bex1 expression is undetectable in adult muscles or in quiescent muscle stem cells (satellite cells). During embryonic myogenesis, however, Bex1 is robustly expressed by myogenin(+) differentiating myoblasts, but not by Pax7(+) proliferating myoblasts. Interestingly, Bex1 is initially localized in the cytoplasm and then translocates into the nucleus. During adult muscle regeneration, Bex1 is highly expressed in newly regenerated myofibers and the expression is rapidly downregulated during maturation. Consistently, in cultured myoblasts, Bex1 is not expressed at the proliferation stage but transiently expressed upon induction of myogenic differentiation, following a similar cytoplasm to nucleus translocation pattern as seen in vivo. Using gain- and loss-of-function studies, we found that overexpression of Bex1 promotes the fusion of primary myoblasts without affecting myogenic differentiation and myogenin expression. Conversely, Bex1 knockout myoblasts exhibit obvious fusion defects, even though they express normal levels of myogenin and differentiate normally. These results elucidate a novel role of Bex1 in myogenesis through regulating myoblast fusion.
Innovation and breaching strategies in multi-sided platform markets: Insights from a simulation study

This study explores how multi-sided digital platforms achieve and sustain superior performance positions in turbulent markets. Specifically, the effects of three major strategies are studied: (1) a complementarity-based innovation strategy, (2) a breaching strategy where a platform expands into rival territories by introducing its offerings in rival platforms to gain access to rivals’ consumers without having to switch them over, (3) the joint use of these strategies. Multi-sided platform markets tend to exhibit turbulence; hence, platform strategies need to focus on achieving and sustaining superior performance positions for longer periods. We use agent-based simulation models to show that innovation and breaching strategies contribute to platform performance. Multisided platforms that pursue a breaching strategy in addition to engaging in innovations achieve higher performance positions than those that only engage in innovations. Our analyses also generated insights about the importance of a fit between the decision rules that platforms follow in implementing their strategies and consumer decision structures.
Organizational Downsizing in a Company Comitted to Workforce Continuity and People Involvement

When you are caught like many others in an industry-wide stagnation it is difficult to uphold the convictions about workforce continuity that are established in boom times. This article reviews a workforce rebalancing process that one high-tech company used to try to avoid layoffs. When layoffs were inevitable, the experience gained in the rebalancing process proved very valuable in handling the layoff procedure.
Volume-activated K+ and Cl- pathways of dissociated eccrine clear cells

In isolated rhesus eccrine clear cells, regulatory volume decrease (RVD) occurs after osmotic swelling. RVD was completely inhibited by 1 mM quinidine, 200 nM charybdotoxin, 1 mM diphenylamine-2-carboxylic acid (DPC), or 0.1 mM 4-nitro-2(3-phenylpropyl-amino)benzoate. RVD was also inhibited in Ca(2+)-free medium by vinblastine (antimicrotubular agent), N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7), or 0.1 mM 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS). Valinomycin reversed quinidine- and DIDS-induced inhibition of RVD but not the inhibition caused by Ca(2+)-free medium, DPC, vinblastine, or W-7. The cytosolic free Ca2+ concentration, as determined by the fura 2 method, increased from 220 nM in the control to 435 nM during RVD. Activation of both K+ and Cl-currents was also directly demonstrated with the whole cell current-voltage clamp method. DIDS inhibited swelling-induced K+, but not Cl-, currents and depolarized the membrane potential during RVD, further supporting the notion that DIDS inhibited swelling-activated K+, but not Cl-, pathways. We conclude that the observed RVD is mediated by the activation of conductive Ca(2+)-dependent K+ and Cl- pathways.
Theranostic Nanoseeds for Efficacious Internal Radiation Therapy of Unresectable Solid Tumors

Malignant tumors are considered “unresectable” if they are adhere to vital structures or the surgery would cause irreversible damages to the patients. Though a variety of cytotoxic drugs and radiation therapies are currently available in clinical practice to treat such tumor masses, these therapeutic modalities are always associated with substantial side effects. Here, we report an injectable nanoparticle-based internal radiation source that potentially offers more efficacious treatment of unresectable solid tumors without significant adverse side effects. Using a highly efficient incorporation procedure, palladium-103, a brachytherapy radioisotope in clinical practice, was coated to monodispersed hollow gold nanoparticles with a diameter about 120 nm, to form 103Pd@Au nanoseeds. The therapeutic efficacy of 103Pd@Au nanoseeds were assessed when intratumorally injected into a prostate cancer xenograft model. Five weeks after a single-dose treatment, a significant tumor burden reduction (>80%) was observed without noticeable side effects on the liver, spleen and other organs. Impressively, >95% nanoseeds were retained inside the tumors as monitored by Single Photon Emission Computed Tomography (SPECT) with the gamma emissions of 103Pd. These findings show that this nanoseed-based brachytherapy has the potential to provide a theranostic solution to unresectable solid tumors.
Water-Pressure Coupling of Sliding and Bed Deformation: III Application to Ice Stream B, Antarctica

Geophysical studies and glaciological analyses suggest strongly that Ice Stream B, West Antarctica, moves primarily by pervasive deformation of a meters thick subglacial till. Analysis of the longitudinal profile of the ice stream up-stream of the ice plain suggests that basal sliding is slow everywhere, that effective pressure decreases slowly down-stream, and that the strain-rate of pervasive shear is proportional to the basal shear stress and inversely proportional to the square or cube of the effective pressure. Discrete shearing may occur beneath the pervasively deforming zone. These and other hypotheses, which build on the analyses of the first two papers in this series, can be tested in the field.
Abstract 4996: The VEGF quadruplex-forming sequence inhibits lung cancer cell growth

Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Vascular endothelial growth factor (VEGF), commonly overexpressed in a variety of malignancies including lung cancer, is a key regulator of angiogenesis promoting tumor survival, growth, and metastasis. The promoters of several cancer-related genes, including VEGF, contain disproportionate sequences within nuclease hypersensitivity regions capable of forming quadruplex (four-stranded) DNA. The VEGF quadruplex-forming sequence (VEGF q), a polyG/polyC tract located in the proximal promoter region upstream of the transcription initiation site, has been implicated in the regulation of both basal and inducible VEGF expression. However, the biological role of this sequence remains unclear. We hypothesize that treatment of A549 non-small lung cancer cells with an oligonucleotide encoding VEGF q inhibits cell growth by decreasing VEGF expression and subsequent signaling through VEGF receptor 2 (FLK-1). To determine the biological role of VEGF on lung cancer cell proliferation, A549 cells were treated with VEGF q or the corresponding mutant sequence (MutVEGF), which lacks runs of two or more guanines. Our results demonstrate that VEGF q formed a parallel quadruplex structure and showed remarkable serum and intracellular stability. Confocal and flow cytometry analysis of cells treated with FITC-labeled VEGF q showed prominent uptake and nuclear/cytoplasmic localization in contrast to MutVEGF. Treatment of A549 cells with VEGF q caused a significant dose and time-dependent decrease in cell proliferation after 3 and 6 days (IC50<5µM) as determined by MTT assay, which was not a result of cell cycle arrest. Matrigel analysis also showed a significant reduction in tumor invasiveness after 24 h with VEGF q treatment. Although uptake of VEGF q occurred in non-transformed Hs27 human fibroblast cells, no change in cell growth was evident, indicating that the anti-proliferative effects of VEGF q are specific for malignant cells. Inhibition of cell proliferation and invasion corresponded with decreased VEGF protein expression resulting in decreased FLK-1 signaling and phosphorylation of the target proteins ERK 1/2 and AKT. These results demonstrate striking growth inhibition and decreased invasion of A549 cells in response to VEGF q related to inhibition of VEGF expression and signaling through FLK-1 and have significant therapeutic implications for the treatment of non-small cell lung cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4996. doi:10.1158/1538-7445.AM2011-4996
The evaluation of clinical curative effect of the traditional Chinese medicine Xiaoerdingchuan formula to treat children's asthma

Objective:To evaluate the clinical therapeutic effect of the Chinese traditional medicine Xiaoerdingchuan formula to treat children's asthma.Methods:40 cases of asthmatic children were divided into 2 groups randomly,each group with 20 cases,the therapy group being used the traditional medicine formula,while the control group having the same treatments with the therapy group except the traditional medicine formula,the whole treatment course for one month.The two groups were observed efficacy and adverse drug reactions.Results:The therapy group with Chinese traditional medicine Xiaoerdingchuan formula,there were 12 cases of cure,6 cases of excellence and 2 case of inefficiency respectively;the effective power rate being was 90%,while there were 5 cases of cure in the control group,6 cases of excellence and 9 cases of inefficiency respectively;the effective power rate was 55%.The difference between the two groups was sig-nificant,P0.05.The toxic and side-effects were not found during the whole treatment course.Conclusion:The clinical therapeutic effect of the Chinese traditional medicine Xiaoerdingchuan formula to treat with the children's asthma was certain and safe.It provides a useful and reliable way to treat with the children's asthma.
Analysis of Biomass Gasification Poisoning Accident Based on Bayesian Network

The gas generated in the biomass gasification contains CO,so it is easy to cause poisoning accidents and serious consequences in biomass gasification station. Considering limitations of the traditional system safety analysis methods in the risk assessment,bayesian network analysis model is introduced. The system fault tree is changed into bayesian networks by Ge NIe software,the fault prediction and diagnosis are conducted by two-side reason function of bayesian networks and the weakness of system can be rapidly and correctly identified. The case application shows that the analysis model of Bayesian networks is practicable for biomass gasification risk analysis and it is more scientific and reasonable than the traditional event tree analysis and fault tree analysis.
Behavioral phenotype in a child with Prader-Willi syndrome and comorbid 47, XYY

We report a 12-year-old male with Prader-Willi syndrome (PWS) and 47, XYY syndrome. Genetic work up revealed 47, XYY karyotype. PWS diagnosis was made by polymerase chain reaction methylation and maternal uniparental disomy (mUPD) was determined to be the etiology. Review of distinct behavioral features, possible interplay between the two syndromes and considerations for diagnoses are presented. To our knowledge, this is the first report of behavioral features in PWS with comorbid 47, XYY.
Variety Trial and Pyrolysis Potential of Kenaf Grown in Midwest United States

Kenaf (Hibiscus cannabinus L.) has potential as an annual herbaceous biomass feedstock. It is not typically grown in the American Midwest; however, kenaf may be attractive as an alternative crop for Iowa and the Corn Belt. In this study, seven kenaf varieties were grown in Iowa and evaluated for their productivity. More specifically, our research questions were the following: (1) how do kenaf varieties perform in Iowa for yield? (2) How does fiber morphology and quality differ among varieties and among core and bast fiber? And (3) What potential does kenaf (bast and core) have for producing fuel using fast pyrolysis? Tainung 2, one of the varieties, reached the best yield in Central Iowa over multiple years. Bast kenaf contained 8 % more cellulose and 23 % less hemicellulose than the core but it varied among varieties. Also, regardless of variety, core was composed of 40 % more lignin than bast. Core was found to have higher potential for fast pyrolysis than the bast but its potential was variety-dependent. Overall, kenaf could be grown to diversify Iowa agriculture and provide alternative feedstock to the biofuel industry.
The Case against Chemical Castration for Sex Offenders

Cet article se penche sur les questions juridiques, medicales, psychologiques et sociales que pose le traitement des agresseurs sexuels a l'Acetate de Medroxyprogesterone (MPA) (ou castration chimique) dans certains Etats des Etats-Unis. Une etude pharmacologique est egalement presentee. Selon les AA., la seule medicalisation de cette question n'est pas la reponse appropriee a un probleme qui recquiert une prise en compte des facteurs humains, comportementaux et sociaux
Quality Circles and Changing Patterns of Communication

Once installed, quality circles produce dramatic results for an organization. They improve morale, increase a sense of loyalty to the organization, and foster a sense of teamwork among employees who participate. They improve overall productivity of the organization, and they improve the quality of the product or service. And they reduce grievances, lost time, accidents, scrap, attrition, absenteeism, and tardiness. In short, they solve problems and save the organization money. (Thompson, 1982, p. 11)
Do muons point to new physics

Your lucid news story reporting preliminary results from the beautiful Muon (g-2) experiment at the Brookhaven National Laboratory in the US (March p5) unfortunately obscures the significance of that experiment (H Brown et at. 2001 Phys. Rev. Lett. 86 2227). The experiment measures the magnetic moment of the muon with unprecedented precision.
A wide-band high-accuracy incremental ADC

In this paper, a high resolution and wideband incremental ADC with extended counting is described and analyzed. The modulator introduced inter-stage gain to reduce the quantization noise without adding any hardware. Also, a gain scaling technique was used to decrease the power consumption by reducing the integrators' output swing. First, the 2nd order incremental ΔΣ ADC and 11-bit SAR ADC were measured separately. Second, the incremental ΔΣ ADC with extended counting was tested. It achieved a 91.6 dB dynamic range and 77.8 dB SNDR in the 0---1.25 MHz signal band. The total power consumption is 53.5 mW with dual power supplies (analog 3.3 V, digital 1.8 V).
Leveraging Research to Advance Undergraduate HRD Education: An Introduction:

The ProblemAs undergraduate human resource development (HRD) programs continue to develop in the United States, faculty face challenges related to finding tools, resources, and curriculum to effect...
Management and outcomes of carotid artery extension of aortic dissections

Abstract Background Aortic dissection (AD) is the most common aortic catastrophe. Carotid artery dissection due to extension of AD (CAEAD) is one severe complication of this condition. Despite years of refinement in the techniques for repair of AD, the optimal management strategy for CAEAD remains yet to be described. We hypothesized that CAEAD eventually resolves on antiplatelet therapy with a low but not insignificant risk of cerebrovascular accident (CVA). Methods This was a single-institution retrospective review of patients admitted with nontraumatic coincident aortic and carotid dissection between 2001 and 2013. Results CAEAD was present in 38 patients (24 men [53%]). The median age was 59.5 years (range, 25-85 years). A Stanford type A AD was diagnosed in 36 patients (95%). CVA or transient ischemic attack was identified in 11 patients (29%). Eight were potentially attributable to the carotid lesion. Two of these eight strokes resulted in death. Of the 11 CVAs and transient ischemic attacks, 8 were evident at presentation, 2 were diagnosed postoperatively during hospitalization, and 1 was diagnosed during early follow-up. Only one of these three postadmission strokes was attributable to the carotid lesion. Nonoperative management of aortic and carotid dissections was pursued in 9 patients (24%), 26 (68%) underwent open repair, and 4 (11%) had endovascular management of AD (2 thoracic endovascular aortic repair, 2 endovascular fenestrations), including 1 patient with a staged hybrid procedure (frozen elephant trunk). There were eight inpatient deaths (21%) and nine deaths in the follow-up period. Of the 30 patients who survived to discharge, 24 (80%) were managed with antiplatelet therapy. At a median follow-up of 14.5 months in 22 patients with follow-up computed tomography scans available, a minority of lesions had resolved, and only one CVA was reported. Conclusions This study found that CAEAD was associated almost exclusively with type A AD, was typically unilateral, most often on the left, and usually persisted at follow-up. Many CAEAD patients presented with CVA and experienced significant early mortality. Notably, not all CVA events were attributable to the CAEAD. CVAs were not common after admission, and there appeared to be a low risk of new or subsequent stroke during follow-up with routine antiplatelet and antihypertensive therapy.
The Impact of Multi-Homing in a Ride-Hailing Market

Platforms such as Uber, Lyft and Airbnb serve two-sided markets with drivers (property owners) on one side and riders (renters) on the other side. Some agents multi-home. In the case of ride-sharing, a driver may drive for both Uber and Lyft, and a rider may use both apps and request a ride from the company that has a driver close by. In this paper, we are interested in welfare implications of multi-homing in such a market. Our model abstracts away from entry/exit by drivers and riders as well as pricing by platforms. Both drivers' and riders' surpluses are determined by the average time between a request and the actual pickup. The benchmark setting is a monopoly platform and the direct comparison is a single-homing duopoly. The former is more efficient since it has a thicker market. Next, we consider two multi-homing settings, multi-homing on the rider side and multi-homing on the driver side. Relative to single-homing duopoly, we find that multi-homing on either side improves the overall welfare. However, multi-homing drivers potentially benefit themselves at the cost of single-homing drivers. In contrast, multi-homing riders benefit themselves as well as single-homing riders, representing a more equitable distribution of gains from multi-homing.
Δ9-tetrahydrocannabinol (Δ9-THC) administration after neonatal exposure to phencyclidine potentiates schizophrenia-related behavioral phenotypes in mice

The clinical onset of schizophrenia often coincides with cannabis use in adolescents and young adults. However, the neurobiological consequences of this co-morbidity are not well understood. In this study, we examined the effects of Δ9-THC exposure during early adulthood on schizophrenia-related behaviors using a developmental mouse model of schizophrenia. Phencyclidine (PCP) or saline was administered once in neonatal mice (at P7; 10mg/kg). In turn, Δ9-THC or saline was administered sub-acutely later in life to cohorts of animals who had received either PCP or saline (P55-80, 5mg/kg). Mice who were administered PCP alone displayed behavioral changes in the Morris water waze (MWM) and pre-pulse inhibition (PPI) task paradigm that were consistent with schizophrenia-related phenotypes, but not in the locomotor activity or novel object recognition (NOR) task paradigms. Mice who were administered PCP and then received Δ9-THC later in life displayed behavioral changes in the locomotor activity paradigm (p<0.001) that was consistent with a schizophrenia-related phenotype, as well as potentiated changes in the NOR (p<0.01) and MWM (p<0.05) paradigms as compared to mice that received PCP alone. Decreased cortical receptor expression of NMDA receptor 1 subunit (NR1) was observed in mice that received PCP and PCP+Δ9-THC, while mice that received Δ9-THC and PCP+Δ9-THC displayed decreases in CB1 receptor expression. These findings suggest that administration of Δ9-THC during the early adulthood can potentiate the development of schizophrenia-related behavioral phenotypes induced by neonatal exposure to PCP in mice.
Occupational Therapy Interventions for Adults With Cancer

This Evidence Connection describes a case report of a man with non-Hodgkin's lymphoma who underwent an allogenic stem cell transplant. The occupational therapy assessment and treatment processes for an outpatient rehabilitation setting are described. Evidence Connection articles provide a clinical application of systematic reviews developed in conjunction with the American Occupational Therapy Association's Evidence-Based Practice Project.
Hedge Funds and Corporate Misreporting

We examine the roles of hedge funds in corporate financial misreporting using a unique dataset of private investments in public equity (PIPEs) transactions. We show that PIPE issuers are more likely to engage in financial misreporting when a hedge fund is the lead investor in the offering. We further find hedge funds do take actions to protect themselves from such risk by requesting significantly more contractual protections. Our results are robust after carefully controlling for the endogeneity issue using the control function approach and the propensity score matching method.
The Meaning of Stochasticity, Randomness and Uncertainty in Environmental Modeling

The concepts of ‘uncertainty’ ‘randomness’ and’ stochasticity’ are being debated and discussed in great detail in the modeling literature. These issues are especially pertinent when comparing various stochastic methods or when calibrating and validating probabilistic models. This paper reviews the use and meaning of ‘uncertainty’,’ stochasticity’ and ‘randomness’ in the area of environmental modeling and proposes working definitions for the use of these terms and the term ‘error’ when reporting modeling work. There is no assumption on the part of the author as to the definitiveness of the suggested definitions. Instead, they are offered as “straw-persons” that are to be discussed, debated and changed as the necessary consensus develops in the modeling community.
Mutual assessment during ritualized fighting in mantis shrimp (Stomatopoda)

Safe and effective conflict resolution is critical for survival and reproduction. Theoretical models describe how animals resolve conflict by assessing their own and/or their opponent's ability (re...
Nonequilibrium flow through porous thermal protection materials, Part II: Oxidation and pyrolysis

Abstract Micro scale simulations are performed of flow through porous (pyrolyzing) thermal protection system (TPS) materials using the direct simulation Monte Carlo (DSMC) method. DSMC results for permeability are validated with computational fluid dynamics (CFD) calculations and theory, for simple porous geometries under continuum flow conditions. An artificial fiber-microstructure generation code FiberGen is used to create triangulated surface geometry representative of FiberForm® (FiberForm) material. DSMC results for permeability of FiberForm are validated for a range of pressures (transitional flow conditions) and agree with experimental measurements. Numerical uncertainty is determined to be within 2% if sufficiently large portions of the microstructure are included in the computation. However, small variations in fiber size and angle bias can combine to give + 30 % uncertainty when comparing with experimental permeability data. X-ray microtomography scans of FiberForm are used to create microstructure geometry for incorporation within DSMC simulations of coupled oxygen diffusion and gas-surface chemistry in the presence of a blowing pyrolysis gas. In-depth penetration of atomic oxygen is limited to 0.2 – 0.4 mm for the range of Knudsen number and pyrolysis gas conditions studied.
The 2018 Revealed-Preferences Ranking of Law Schools

In 2017, we published A Revealed-Preferences Ranking of Law Schools, which presented the first (intentionally) subjective ranking of law schools based on the revealed preferences of matriculating students. We created a subjective ranking system as an alternative to other law school rankings, which are objective, because their purpose is to tell prospective law students where to matriculate. Our “revealed-preferences” ranking is subjective, because its purpose is to ask where prospective law students choose to matriculate. In other words, objective rankings tell students what they should want, but our subjective ranking asks what students actually want. In this article, we altered our methodology to present a law school ranking based exclusively on the combined scores of the students in a school’s 2017 incoming class. We also compare this ranking to our previous ranking, as well as other objective ranking systems, and provide regional rankings of law schools.