cssi/SciSciGPT-SciSciNet huggingface dataset:
21 EXERCISE-INDUCED ASYSTOLE WITH SYNCOPE IN A HEALTHY YOUNG MAN.

Purpose Exercise-related syncope is frequently an ominous symptom associated with advanced cardiovascular disease. Asystole during or following exercise is a rare occurrence in persons with structural heart disease and is an even rarer cause of syncope in healthy persons. Neurocardiogenic syncope describes a loss of consciousness resulting from impaired cerebral perfusion due to abnormal autonomic activity. It is expressed in two forms: the more common vasodepressor variant with abnormal regulation of systemic vascular resistance and a vagal variant with inappropriate cardiac slowing related to augmented vagal nerve activity. Case Report Herein we report on a healthy 40-year-old male who was hospitalized after a syncopal episode that followed his playing basketball. He recalled several near-syncopal episodes after strenuous exercise over the past 6 months during which time he used marijuana, but not alcohol or cocaine, and was not receiving prescribed medications or taking across-the-counter agents. Cardiopulmonary disease was not detected by either physical examination or various investigatory studies. Ten minutes of monitored, incremental treadmill exercise test was associated with a rise in heart rate to 137 bpm (from a resting bradycardia of 51 bpm) and blood pressure to 144/74 (136/78 mm Hg at rest). During the immediate recovery period, sinus bradycardia appeared at 30 seconds followed by a 7-second period of sinus arrest and ventricular asystole with syncope. Consciousness returned thereafter with the spontaneous appearance of sinus tachycardia (109 bpm). The presumptive vagal origin of his sinoatrial arrest and asystole prompted placement of a dual-chamber permanent pacemaker. No further syncopal episodes have been reported, despite his continued participation in basketball and smoking marijuana. Discussion The loss of sinoatrial activity and appearance of ventricular asystole immediately following strenuous exercise are in keeping with the vagal variant of neurocardiogenic syncope. Such parasympathetic dominance could be related to (a) his recent, chronic cannabinoid use, where experimental studies have shown cannabidiol produces bradycardia and asystole; (b) an “insufficient” release of a vagal inhibitor, neuropeptide Y during exercise; or (c) a cannabinoid-neuropeptide interaction, which has been identified to occur in the hypothalamus.
Molecular phylogeny of the kinesin family of microtubule motor proteins

The rapidly expanding kinesin family of microtubule motor proteins includes proteins that are involved in diverse microtubule-based functions in the cell. Phylogenetic analysis of the motor regions of the kinesin proteins reveals at least five clearly defined groups that are likely to identify kinesins with different roles in basic cellular processes. Two of the groups are consistent with overall sequence similarity, while two groups contain proteins that are related in overall structure or function but show no significant sequence similarity outside the motor domain. One of these groups consists only of kinesin proteins with predicted C-terminal motor domains; another includes only kinesins required for mitotic spindle bipolarity. Drosophila Nod, presently an ungrouped protein, may represent a class of kinesins that, like the myosin I proteins, function as monomers. The analysis indicates that many types of kinesin proteins exist in eukaryotic organisms. At least two of the five groups identified in this analysis are expected to be present in most, or all, eukaryotes.
Research and Application Overview of ACCC Conductor in China

The aluminum conductor with reinforced core of carbon fiber is a brand new conductor for overhead transmission lines.Making full used of composite material properties,it is characterized by high strength,large transmission capacity,high temperature resistance,small thermal expansion,light weight,corrosion resistance,etc.The paper introduces its research and application in china including conductor,fitting,construction and operation,and gives out some suggestions to the future progress.
Influence of Fan Volute Height on Cooling Duct Airflow of Armored Vehicles

In order to efficiently reduce the airflow resistance in a closed cooling duct of an armored vehicle,the numerical simulation is accomplished by means of computational fluid dynamics.A simulation model of the cooling air duct is built in GT-Suite,and the 3D model is dispersed with the help of GT-Cool module.The influence of the height changes of the fan volute is studied on the main design parameters of the cooling air duct.The results show that the airflow resistance becomes too big when the height of the volute is less than 257 millimeter.The average velocity of the airflow at the inlet section of the low temperature radiator increases after redesigning the structure of the fan volute.
Long-term prognosis factors for patients having received surgery for lung sarcomatoid carcinoma: an analysis of 22 cases

Objective: To explore the factors influencing the survival and long-term prognosis of patients having undergone surgical operation for lung sarcomatoid carcinoma. Methods: The clinical data of 22 cases who had received surgical treatment for lung sarcomatoid carcinoma were retrospectively reviewed. The potential prognostic factors were analyzed by COX' s proportional hazard regression model. Results: The overall 1,3 and 5-year survival rates were 63. 6%,18. 2% and 4. 5%,respectively. p-TNM stage and N status were valued as prognostic factors in COX univariate analysis( P 0. 05). Age,p-TNM stage and type of pathology were identified as independent prognostic factors by COX multivariate analysis( P 0. 01). Conclusions: There is no effective therapy for lung sarcomatoid carcinoma and the 5-year survival rate is quite low. Age,p-TNM stage and type of pathology are the crucial prognostic factors for patients with lung sarcomatoid carcinoma.
An analysis on TB information published by newspapers in 2011 in Henan

Objective To analysis TB information published by newspapers in 2011 in Henan, to supply the foundation to make TB information communication strategy. Methods Conducted an analysis on TB-related information published by 25 newspapers in 2011 in Henan. Used the Microsoft Office Access 2007 software to statistic separately by number, subject, source and genre. Results 71 pieces of TB-related information was published by newspapers in Henan in 2011, among them 35 pieces were published in March. 40.80 % of the information were based on the theme of TB prevention and treatment knowledge popularized; 76.00 % of the sources of information were from TB control institutions and experts and scholars; 60.10 % of the genres were messages. Conclusions The amount of the published information is relatively small and not balanced; the subject, source genre of the information are relatively homogeneous and lack of diversity. In-depth, comprehensive and sustained TB-related information should be published by newspapers. A multi-sectoral participation should be founded in TB control.
Inhibin activity and steroid hormone levels in ovarian extracts and ovarian vein plasma of female monkeys during postnatal development

Inhibin activity, follicle-stimulating hormone (FSH)-suppressing substance, estrogen, progesterone, and androstenedione were measured in charcoal-treated ovarian tissue and ovarian venous and peripheral blood of eight rhesus monkeys ranging from 12 to 48 months of age. All of the monkeys demonstrated inhibin activity in ovarian tissue, which, if expressed per milligram protein, was relatively constant throughout development. However, if the activity was expressed per ovary, the amount of ovarian FSH-suppressing substance increased between 26 and 48 months; it was present in detectable amounts in ovarian venous blood only in one 26-month-old monkey. Detectable levels of estrogen were present in ovarian venous blood of the 26-month-old and the 48-month-old monkeys but not in the younger monkeys. It is possible that the secretion of inhibin activity may be in part responsible for low levels of serum FSH observed prior to puberty, because it has been observed by others that bilateral ovariectomy in the prepubertal monkey can result in a rise in FSH and that administration of charcoal-treated ovarian follicular fluid can suppress serum FSH in castrated prepubertal and adult rhesus monkeys.
Interpreting the prediction process of a deep network constructed from supervised topic models

In this paper, we propose an approach to interpret the prediction process of the BP-sLDA model, which is a supervised Latent Dirichlet Allocation model trained by Back Propagation over a deep architecture. The model is shown to achieve state-of-the-art prediction performance on several large-scale text analysis tasks. To interpret the prediction process of the model, often demanded by business data analytics applications, we perform evidence analysis on each pair-wise decision boundary over the topic distribution space, which is decomposed into a positive and a negative components. Then, for each element in the current document, a novel evidence score is defined by exploiting this topic decomposition and the generative nature of LDA. Then the score is used to rank the relative evidence of each element for the effectiveness of model prediction. We demonstrate the effectiveness of the method on a large-scale binary classification task on a corporate proprietary dataset with business-centric applications.
Solving MINLP containing noisy variables and black-box functions using Branch-and-Bound

Abstract Since existing MINLP solvers such as DICOPT require the existence of explicit deterministic equations, they are unable to address systems containing noise and unknown model equations. In this paper we propose a new algorithm based on a Branch-and-Bound main structure to solve MINLP problems involving noise and black-box models, where a response surface method developed in our earlier work is applied to solve a noisy NLP at each node of the branch and bound tree. The algorithm is applied to an example problem to further clarify the steps of the proposed approach.
Pilot Evaluation of a Palliative and End-of-Life Communication Intervention for Parents of Children With a Brain Tumor:

Providing timely palliative and end-of-life care (PC/EOL) information to parents of children with a serious illness is a national health care priority. The goals of this study were to determine feasibility, acceptability, and parent responses related to a PC/EOL communication intervention, titled "Communication Plan: Early through End of Life (COMPLETE)" to parents of children with a brain tumor. The study was a 2-site prospective, single-group pilot study targeting parents' stress and coping outcomes. The sample included 13 parents of 11 children (ie, 11 families). During the first 6 months postdiagnosis, we evaluated parent outcomes at 4 time points (baseline and 3 post-sessions). Our findings included significant decline in decision regret ( P = .0089); strong, significantly increased hope ( P ≤ .0001); and significantly decreased uncertainty ( P = .04). Over time, more than half of the parents (61.5%) preferred to receive information about their child's current condition and PC/EOL options. Our findings provide evidence to suggest that the COMPLETE intervention is feasible and acceptable and produces promising effects on 3 parent outcomes (ie, decision regret, hope, and uncertainty) in parents of children with a brain tumor. Further research is indicated to evaluate COMPLETE with a larger sample of parents of children with cancer and with a control group.
El género Monarda en México

Las especies y variedades del genero Monarda que crecen en Mexico y las regiones adyacentes del sur de Texas, Nuevo Mexico y Arizona son descritas y comentadas. Claves para los taxa individuales son incluidos. Especulaciones fitogeograficas sobre el origen del genero son presentadas. Una investigacion quimica sobre los aceites esenciales se indica, y cromatogramas de especies representativas estan incluidos. Mapas de distribucion geografica y aspectos morfologicos de hojas, corolas y calices son ilustrados.
Do Emotions Spark Interest in Alternative Tobacco Products

Background. Exposure to advertisements for tobacco products and tobacco warning labels evokes emotions. This study evaluated the association of discrete positive and negative emotions with interest...
Optics and Interferometry with Atoms and Molecules

Publisher Summary This chapter discusses recent accomplishments in the atom and molecular optics and interferometry at MIT. The chapter begins with a discussion of the details of an experimental apparatus and gives an overview of recent accomplishments in atom and molecular optics. It then describes the atom and molecule interferometer, which is unique in that the two interfering components of the atom wave are spatially separated and can be physically isolated by a metal foil. The interferometer is especially well suited for the study of atomic and molecular properties as it enables one to apply different interactions to each of the two components of the wave function, which in turn permits spectroscopic precision in the study of interactions that shift the energy or phase of a single state of the atom. The chapter also describes an experiment in which this capability is used to determine the ground state polarizability of sodium to 0.3%—an order of magnitude improvement—by measuring the energy shift due to a uniform electric field applied to one component of the wave function. The chapter also provides an overview of the relativistic effects in electromagnetic interactions, and differential force interferometry.
Spiritual Selfishness: The Limitations of Dance in Klaus Mann's Der fromme Tanz and Die zerbrochenen Spiegel

Klaus Mann’s knowledge of writing and staging plays led to interest in exploring dance. His novel Der fromme Tanz (1925) and the dance-pantomime libretto Die zerbrochenen Spiegel (1926) deal specifically with this movement medium. This article first addresses Mann’s experience of watching Weimar dance performances, which developed his idea of “erschutternde Anmut,” and explores its connection with his conceptualization of spirituality. The novel’s protagonist, Andreas Magnus, desires to break away from his bourgeois home and embark on a “pious dance” in Berlin. In the pantomime, the main character, Prinz Narzissus, lives a decadent, self-absorbed existence, dancing ecstatically between three mirrors, but gives no regard to an impending mass of workers. I argue that, for Mann, dance serves predominantly as a solitary spiritual guide that celebrates the body and the carnal. This self-absorbed model, however, does not fit into the changing society of the workers’ demonstration and demands social awareness.
An update on the OpenOrbiter I Mission and its paradigm's benefits for the defense, homeland security and intelligence communities

The OpenOrbiter I spacecraft is the culmination of significant work on reducing the cost levels of a CubeSat-class spacecraft. By redesigning the spacecraft from the ground up, down to the component level, to use readily available electronic and physical components, the cost of CubeSat construction has been significantly reduced. This paper provides an overview of the OpenOrbiter I mission, to date. It then focuses on the benefits that can be provided by the lower-cost, low-risk spacecraft. The paper discusses the prospective utility of this mission paradigm for the defense, homeland security and intelligence communities.
India’s daughter directed by Leslee Udwin

India’s Daughter documents a brutal gang rape that took place on 16 December 2012 in New Delhi, the capital city of India. A 23-year-old physiotherapy intern, Jyoti Singh, was savagely attacked in ...
Resolving Barriers to Access to the General Curriculum: Lessons From an Exemplary Inclusive District

Abstract Although access to general curriculum content is most likely to occur in general education contexts, teachers and educational personnel are often challenged to implement the practice. In t...
Asymmetric Brønsted acid catalysis with chiral carboxylic acids.

Chiral Bronsted acids have found widespread applications as organocatalysts. Weakly acidic species such as diols and (thio)ureas, typically classified as hydrogen bonding catalysts, as well as stronger phosphoric acids, have proven to be highly effective in catalyzing a wide range of asymmetric transformations. In contrast, the use of chiral carboxylic acids as Bronsted acid catalysts is much less developed but has recently garnered increased attention. Given that their pKa's generally lie between those of typical hydrogen bond donors and chiral phosphoric acids, chiral carboxylic acids provide the opportunity to activate a different set of substrates requiring intermediate catalyst acidity. In addition, by taking advantage of judicious catalyst design, the acidity of carboxylic acids can be modulated, for instance by stabilizing the corresponding carboxylate counterion. This review provides an overview of this field, with the aim of highlighting both catalyst design and synthetic applications.
Who Performs Colonoscopy? Workforce Trends Over Space and Time

PURPOSE With the increased availability of colonoscopy to average risk persons due to insurance coverage benefit changes, we sought to identify changes in the colonoscopy workforce. We used outpatient discharge records from South Carolina between 2001 and 2010 to examine shifts over time and in urban versus rural areas in the types of medical providers who perform colonoscopy, and the practice settings in which they occur, and to explore variation in colonoscopy volume across facility and provider types. METHODS Using an all-payer outpatient discharge records database from South Carolina, we conducted a retrospective analysis of all colonoscopy procedures performed between 2001 and 2010. FINDINGS We identified a major shift in the type of facilities performing colonoscopy in South Carolina since 2001, with substantial gains in ambulatory surgery settings (2001: 15, 2010: 34, +127%) versus hospitals (2001: 58, 2010: 59, +2%), particularly in urban areas (2001: 12, 2010: 27, +125%). The number of internists (2001: 46, 2010: 76) and family physicians (2001: 34, 2010: 106) performing colonoscopies also increased (+65% and +212%, respectively), while their annual procedures volumes stayed fairly constant. Significant variation in annual colonoscopy volume was observed across medical specialties (P < .001), with nongastroenterologists having lower volumes versus gastroenterologists and colon and rectal surgeons. CONCLUSIONS There have been substantial changes over time in the number of facilities and physicians performing colonoscopy in South Carolina since 2001, particularly in urban counties. Findings suggest nongastroenterologists are meeting a need for colonoscopies in rural areas.
lib•erate, (n): a library for exposing (traffic-classification) rules and avoiding them efficiently

Middleboxes implement a variety of network management policies (e.g., prioritizing or blocking traffic) in their networks. While such policies can be beneficial (e.g., blocking malware) they also raise issues of network neutrality and freedom of speech when used for application-specific differentiation and censorship. There is a poor understanding of how such policies are implemented in practice, and how they can be evaded efficiently. As a result, most circumvention solutions are brittle, point solutions based on manual analysis. This paper presents the design and implementation of lib•erate, a tool for automatically identifying middlebox policies, reverse-engineering their implementations, and adaptively deploying custom circumvention techniques. Unlike previous work, our approach is application-agnostic, can be deployed unilaterally (i.e., only at one endpoint) on unmodified applications via a linked library or transparent proxy, and can adapt to changes to classifiers at runtime. We implemented a lib•erate prototype as a transparent proxy and evaluate it both in a testbed environment and in operational networks that throttle or block traffic based on DPI-based classifier rules, and show that our approach is effective across a wide range of middlebox deployments.
Fyn-binding protein ADAP supports actin organization in podocytes

The renal podocyte is central to the filtration function of the kidney that is dependent on maintaining both highly organized, branched cell structures forming foot processes, and a unique cell-cell junction, the slit diaphragm. Our recent studies investigating the developmental formation of the slit diaphragm identified a novel claudin family tetraspannin, TM4SF10, which is a binding partner for ADAP (also known as Fyn binding protein Fyb). To investigate the role of ADAP in podocyte function in relation to Fyn and TM4SF10, we examined ADAP knockout (KO) mice and podocytes. ADAP KO mice developed glomerular pathology that began as hyalinosis and progressed to glomerulosclerosis, with aged male animals developing low levels of albuminuria. Podocyte cell lines established from the KO mice had slower attachment kinetics compared to wild-type cells, although this did not affect the total number of attached cells nor the ability to form focal contacts. After attachment, the ADAP KO cells did not attain typical podocyte morphology, lacking the elaborate cell protrusions typical of wild-type podocytes, with the actin cytoskeleton forming circumferential stress fibers. The absence of ADAP did not alter Fyn levels nor were there differences between KO and wild-type podocytes in the reduction of Fyn activating phosphorylation events with puromycin aminonucleoside treatment. In the setting of endogenous TM4SF10 overexpression, the absence of ADAP altered the formation of cell-cell contacts containing TM4SF10. These studies suggest ADAP does not alter Fyn activity in podocytes, but appears to mediate downstream effects of Fyn controlled by TM4SF10 involving actin cytoskeleton organization.
Coagulase Activity of Bovine Clinical Isolates and Phage Propagating Strains of Staphylococcus

During the past year we have been studying strains of staphylococci isolated from bovine udders, and made quantitative determinations of coagulase activity of these and of two sets of phage-propagating strains. Phage typing was accomplished by the techniques of Blair and Carr (J. Inf. Dis. 93: 1–13, 1953) using 24 phages of the Blair-International series as well as six bovine-adapted phages prepared by Seto and Wilson (Am. J. Vet. Res. 19:241–246, 1958). The tube dilution technique of Tager (Yale J. Biol, and Med. 20:487–501, 1948) was used for the estimation of free coagulase. Staphylococci from 166 milk samples collected from 93 cows on 23 farms were phage-typed with the two sets of phages.
The Pursuit of Evidence-Based Practice in Special Education for Children with Emotional or Behavioral Disorders.

Colleagues in the field of mental health have made considerable progress developing inventories of evidence-based practice; however, the field of special education for children with emotional or be...
Herbicide Programs Utilizing Halauxifen-Methyl for Glyphosate-Resistant Horseweed (Conyza canadensis) Control in Soybean

Evolution of glyphosate-resistant (GR) weeds, such as horseweed, presents major challenges in no-till soybean production systems. Effective GR horseweed control with preplant burndown applications is necessary to prevent potential soybean yield losses due to competition and to manage the soil weed seedbank. Halauxifen-methyl is a new synthetic auxin herbicide for broadleaf weed control in preplant burndown applications for soybean and other crops at low use rates (5 g ae ha–1). Experiments were conducted to evaluate the efficacy of herbicide treatments containing halauxifen-methyl for control of GR horseweed in comparison to existing herbicide treatments utilized in no-till GR soybean systems. Glyphosate alone controlled horseweed 33%. Herbicide treatments that included halauxifenmethyl, dicamba, or saflufenacil in combination with glyphosate controlled horseweed 87% to 96%, 89%, and 93%, respectively, 35 d after burndown application (DAB). Horseweed control, horseweed density reduction, and ground cover reduction by halauxifen-methyl plus glyphosate was similar to dicamba plus glyphosate. Horseweed control was greater for halauxifen-methyl plus glyphosate than for 2,4-D plus glyphosate. Cloransulam, cloransulam plus flumioxazin, and cloransulam plus sulfentrazone added to halauxifenmethyl plus glyphosate increased horseweed control and reduced horseweed density. No herbicide injury or soybean yield reduction was observed for treatments containing halauxifen-methyl.Nomenclature: 2,4-D; dicamba; glufosinate; glyphosate; halauxifen-methyl; saflufenacil; horseweed, Conyza canadensis (L.) Cronq. ERICA; soybean, Glycine max (L.) Merr.
Under threat but engaged: Stereotype threat leads women to engage with female but not male partners in math.

Abstract This research tests how experiencing stereotype threat before a dyadic interaction affects women’s engagement with peers during a dyadic math task. In a pilot study (N = 167; Mage = 20.1 years), women who completed a manipulation of stereotype threat (a socially evaluative math task in front of male evaluators) experienced greater subjective threat than did men. In Studies 1A and 1B, math-identified female undergraduates completed the stereotype threat or control (doing math alone) manipulation and then completed a collaborative math task with another female or male student (who completed the control task). Sympathetic nervous system responses were collected to measure physiological linkage—the effect of participants’ physiological states on their partners’ subsequent physiological states—as an indicator of attention to the partner. We also measured the number of math-related questions participants asked their partners and task performance. In Study 1A (female-female dyads; N = 104; Mage = 19.9 years), threatened women asked more questions than controls did and became physiologically linked to their partners when those partners were speaking about math. Threatened women performed comparably to controls. In Study 1B (female-male dyads; N = 140; Mage = 20.0 years), threatened women did not ask more questions of their male partners than controls did, nor did they show physiological linkage to their male partners. Women performed worse than men did, regardless of condition. When working with a female, experiencing stereotype threat outside of a working interaction leads women to engage more; this effect does not occur when with a male.
Microgrid Power Optimal Control with Markov Decision Process by Using the Specific Policy of Wavelet Packet-Fuzzy Control

The purpose of this research is to formulate an brand new optimization model, and determine comprehensive optimal operating strategies for microgrid in order to significantly reduce the unbalanced power. This paper presents a microgrid power optimal dispatch control scheme by using markov decision process (MDP). To decrease the exchange power of PCC and smooth the fluctuation, the reward function of MDP is established based on improved entropy. The decision process gets the optimal policy and optimal entropy value through policy iteration. To reduce the policy set, a specific stable policy of wavelet packet-probability fuzzy control has been proposed, which is used as the mapping from state set of state of charge (SOC) of energy storage to action set of charge/discharge power of hybrid energy storage. Case study is tested and the results show that the unbalanced power can be significantly reduced and the fluctuation can be decreased by using the proposed optimal model and specific stable policy.
Münchausen by Proxy

Factitious disorder by proxy, popularly known as Munchausen by proxy (MBP), is a condition in which a parent or caretaker on multiple occasions falsifies symptoms or actually induces illness in an infant or older child, frequently while in a hospital setting. First described by British pediatrician Roy Meadow in 1977, MBP is one of the most perplexing disorders in all medicine.
Before Empire: State Formation in China and Proto-states Elsewhere

East Asia has a long prehistory, but its recorded history spans only the last 4000 years for China, about 2000 for the rest of the region. By 4000 years ago, several unrelated language phyla were established, a fact important for understanding the spread of agriculture and civilization. China’s history begins with the Xia Dynasty, continues through Shang and Zhou. Zhou fell apart into warring states, whose competition stimulated thought and technical progress. From this arose a number of ideas for statecraft and governance, ranging from near anarchy through kinship-based and kinship-modeled government to a strong “legalist” tradition of government by strict laws and regulations. These systems later were incorporated in the ruling strategies of the great dynasties. Agricultural science and metallurgy progressed.
The Changing Face of Human Immunodeficiency Virus-Mediated Kidney Disease

In nearly 40 years since human immunodeficiency virus (HIV) first emerged, much has changed. Our understanding of the pathogenesis of HIV infection and its effect on the cells within each kidney compartment has progressed, and the natural history of the disease has been transformed. What was once an acutely fatal illness is now a chronic disease managed with oral medications. This change is largely due to the advent of antiretroviral drugs, which have dramatically altered the prognosis and progression of HIV infection. However, the success of antiretroviral therapy has brought with it new challenges for the nephrologist caring for patients with HIV/acquired immune deficiency syndrome, including antiretroviral therapy–induced nephrotoxicity, development of non-HIV chronic kidney disease, and rising incidence of immune-mediated kidney injury. In this review, we discuss the pathogenesis of HIV infection and how it causes pathologic changes in the kidney, review the nephrotoxic effects of select antiretroviral medications, and touch upon other causes of kidney injury in HIV cases, including mechanisms of acute kidney injury, HIV-related immune complex glomerular disease, and thrombotic microangiopathy.
A new P1 weak Galerkin method for the Biharmonic equation

Abstract A new weak Galerkin (WG) finite element method is designed featuring in using the first order polynomial to approximate solution of biharmonic equation. The proposed P 1 WG method achieves O ( h ) convergence in energy norm and O ( h 2 ) in L 2 norm in solving the biharmonic equation. This is not possible for the traditional finite element method as the minimum polynomial degree is 2 in order to approximate the biharmonic equation. Numerical tests on various polygonal meshes verify the theory.
Abstract #LB-84: Secretome analyses from staged pancreatic cancer cell lines

Pancreatic ductal adenocarcinoma has the lowest 5-year survival of any cancer; its aggressive nature and late onset of physical symptoms lead to poor prognoses. Pancreatic cancer primarily occurs in the exocrine portion of the organ, with fewer occurrences in the endocrine section. Approximately 95% of cancerous exocrine tumors are derived from ductal cells, while a smaller fraction of tumors are from acinar cells. Recognition of biomarkers is clearly an imperative undertaking for the disease. To tackle this problem, we are attempting to evaluate the secreted protein profile of pancreatic cancer cell lines derived from different stages. Critical to the success of this workflow is the derivation of cells that are sustainable without overt morphological changes in peptide- and protein-free media conditions or dramatic necrosis over a 72 hr profile. We have successfully adapted ten human pancreatic cancer cell lines into low serum environments and pursue collection of conditioned media by a combination of ultracentrifugation, molecular weight cutoff, protein precipitation, gel-based separation, and tryptic digestion followed by MALDI-ToF-MS protein identification. Preliminary data suggested significant cellular autolysis that liberated cytosolic proteins such as beta-actin. Therefore, to minimize cytosolic contamination, cell lines were subsequently cultured from low-serum conditions to synthetic basement membranes in a serum-free media to phenocopy the ductal environment typical for these cells. Consistent with cancer progression models and increased secretory function, earlier-stage pancreatic cancer cell lines showed generally lower protein secretion while later stage cell lines showed generally increased secretion. A catalog of proteins is being compiled in ProteinScape (Bruker Daltonics) and validated biochemically including positive identifications for Glutathione S-Transferase pi (GSTP1), Galectin-3 (GAL3), and Palladin (PALLD)_three proteins that have been correlated with tumor secretions from prostate, breast, and pancreatic cancer, respectively. Taken together, our reproducible workflow demonstrates the utility of assessing the secretome fraction from cultured cancer cells. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-84.
Planning a CIS education within a CS framework

The Computer Science Department at University of Mary Washington revised its curriculum to include a Computer Information System (CIS) concentration to increase the number of computer science majors at the University. Several universities, including Winoa State University, University of South Caroline Spartanburg, and Northwest Missouri State University, have introduced interdisciplinary application tracks in Computer Science (CS) to increase retention, to support the evolving nature of computer science such that it supports other disciplines, and to meet the job growth in all computing specialties forecast by the U.S. Bureau of Labor Statistics. The motivation behind our change came from the decreasing number of majors, the abundance of business majors at the University, and the Computing Curricula 2005 report. The University currently does not offer any minors and double majors can be difficult.
Accelerator-aware Neural Network Design using AutoML

While neural network hardware accelerators provide a substantial amount of raw compute throughput, the models deployed on them must be co-designed for the underlying hardware architecture to obtain the optimal system performance. We present a class of computer vision models designed using hardware-aware neural architecture search and customized to run on the Edge TPU, Google's neural network hardware accelerator for low-power, edge devices. For the Edge TPU in Coral devices, these models enable real-time image classification performance while achieving accuracy typically seen only with larger, compute-heavy models running in data centers. On Pixel 4's Edge TPU, these models improve the accuracy-latency tradeoff over existing SoTA mobile models.
A virtual plant for integrated continuous manufacturing of a carfilzomib drug substance intermediate. Part 1: CDI-promoted amide-bond formation

This manuscript details process characterization efforts and the development of corresponding process models to inform a process control strategy to produce a carfilzomib drug substance intermediat...
Hand therapists' knowledge and practice-related beliefs about pain science: A survey study.

Abstract Introduction Identifying hand therapists' knowledge and beliefs about pain can illuminate familiarity with modern pain science within hand therapy. Purpose of the Study The primary aim was to identify hand therapists' knowledge of pain neurophysiology. Secondary purposes were to explore demographic variation in knowledge, describe practice-related beliefs about pain science, and explore associations between knowledge and beliefs. Study Design Cross-sectional descriptive survey study. Methods An electronic survey, including the Revised Neurophysiology of Pain Questionnaire (R-NPQ) and Likert-type questions about practice-related beliefs, was distributed to American Society of Hand Therapists members. Results Data from 305 survey responses were analyzed. R-NPQ accuracy ranged from 42% to 100%, with a mean of 75% (9/12 ± 1.5). Certified hand therapists scored, on average, 0.8 points lower than their noncertified peers. Participants with a doctoral degree scored 0.7 or 0.6 points higher, respectively, than those with a bachelor's or master's degree. Objective knowledge of pain neurophysiology was positively associated with perceived knowledge of pain science (ρ = .31, P Conclusions Although hand therapists recognized the importance of knowing pain science, they had objective and subjective limitations in that knowledge. Specific errors in their R-NPQ responses suggest misconceptions related to the modern differentiation between nociception and pain. Blurring of these constructs may relate to participants' self-reported practice emphasis on acute versus chronic conditions. Future studies should explore knowledge, attitudes, and beliefs about pain beyond R-NPQ scores to understand variation in practice and training needs.
Experiment characterization and formulation estimation of tensile properties for selective laser melting manufactured 304L stainless steel

Abstract Additive manufacturing (AM) becomes more and more prevalent and offers enormous benefits on account of its inherent layer-by-layer nature. Material characterizations of such printed metal alloy are essential and necessary to understand the unique process-properties maps of different structures. From which, the tensile performance is one of the most demanding and concerning behaviors by diverse requirements from industries. In this study, experimental methodologies (uniaxial tensile testing and automated ball indentation testing) and constitutive relations (Holloman, Swift, Voce, and Ludwigson formulation) studies were performed to AISI 304L stainless steel. A comparative study was presented between selective laser melting fabricated parts and conventional counterparts. Outputs indicated the Swift formulations provided the best estimations of the flow curve. All four formulations provided reasonable estimations of ultimate tensile strength. Anisotropic study in tensile strength and work hardening exponent with varying build orientations were correlated to grain structures. The non-destructive automated ball indentation test yielded the acceptable tensile strength with the accurate determination of plastic chordal diameter. However, the automated ball indentation test demonstrated an insensitive manner on the anisotropy.
Moving load identification on Euler-Bernoulli beams with viscoelastic boundary conditions by Tikhonov regularization

This work presents moving load identification on Euler-Bernoulli beams with viscoelastic boundary conditions based on beam acceleration responses. The Tikhonov regularization and generalized cross ...
Pairing in graphene-based moiré superlattices

This work provides a systematic classification and energetic analysis of superconducting instabilities in different moir\'e superlattices of graphene. The authors show that these systems, even in the absence of spin-orbit coupling, can naturally exhibit spin-singlet and triplet admixture. The paper studies which of the possible pairing states can be realized in the weak coupling limit, and investigates the consequences of additional fluctuation corrections of nearby correlated insulators.
Plasma Amino Acid Response to Whey Protein Ingestion Following 28 Days of Probiotic (Bacillus subtilis DE111) Supplementation in Active Men and Women.

We sought to determine if 28 days of probiotic supplementation influenced the plasma amino acid (AA) response to acute whey protein feeding. METHODS: Twenty-two recreationally active men (n = 11; 24.3 ± 3.2 yrs; 89.3 ± 7.2 kg) and women (n = 11; 23.0 ± 2.8 yrs; 70.2 ± 15.2 kg) participated in this double-blind, placebo-controlled, randomized study. Before (PRE) and after 28 days of supplementation (POST), participants reported to the lab following a 10-hr fast and provided a resting blood draw (0 min), then subsequently consumed 25 g of whey protein. Blood samples were collected at 15-min intervals for 2 h post-consumption (15–120 min) and later analyzed for plasma leucine, branched-chain AA (BCAA), essential AA (EAA), and total AA (TAA). Participants received a probiotic (PROB) consisting of 1 x10-9 colony forming units (CFU) Bacillus subtilis DE111 (n = 11) or a maltodextrin placebo (PL) (n = 11) for 28 days. Plasma AA response and area under the curve (AUC) values were analyzed via repeated measures analysis of variance. RESULTS: Our analysis indicated no significant (p < 0.05) differential responses for plasma leucine, BCAA, EAA, or TAA between PROB and PL from PRE to POST. AUC analysis revealed no group × time interaction for plasma leucine (p = 0.524), BCAA (p = 0.345), EAA (p = 0.512), and TAA (p = 0.712). CONCLUSION: These data indicate that 28 days of Bacillus subtilis DE111 does not affect plasma AA appearance following acute whey protein ingestion.
Functional connectome mediates the association between sleep disturbance and mental health in preadolescence

BackgroundSleep disturbance is known to be associated with various mental disorders and typically precedes the onset of mental disorders in youth. Given the increasingly acknowledged bi-directional influence between sleep disturbance and mental disorders, we addressed the possibility of a shared neural mechanism that underlies sleep disturbance and mental disorders in preadolescents. MethodsWe analyzed a dataset of 9350 9-10 year-old children, among whom 8845 had one-year follow-up data, from the Adolescent Brain and Cognitive Development (ABCD) Study. Linear mixed-effects models, mediation analysis, and longitudinal mediation analysis were used. ResultsOut of 338 unique connectivities, the effect of total sleep disturbance (TSP, from Sleep Disturbance Scale) and total problems (TP, from Child Behavior Checklist) converged in the default mode network (DMN) and its anti-correlated dorsal attention network (DAN). Within- and between-network connectivities (DMN-DAN, DMN-DMN, DAN-DAN) mediated the relationship between baseline TSD and TP at one-year follow-up and the relationship between baseline TP and TSD at one-year follow-up. Moreover, the identified network connectivities (DMN-DAN, DAN-DAN) also correlated with the total cognitive composite score from the NIH toolbox. ConclusionsThe pathway model in which sleep disturbance and mental problems affect each other through two anticorrelated brain networks (DMN and DAN) suggests a common neural mechanism between sleep disturbance and mental disorders. A less segregated DMN and DAN is also associated with negative outcomes on mental well-being, sleep disturbance, and cognition. These findings have important implications for the design of prevention and neurofeedback intervention for mental disorders and sleep problems. HighlightsO_LIThe impact of sleep disturbance and mental disorders on functional connectivity converged in default mode and dorsal attention networks. C_LIO_LIThe relationship between sleep disturbance and mental disorders was mediated via a shared brain network mechanism C_LIO_LISleep disturbance and mental disorders at baseline can each predict the other one year later through the identified network connectivities C_LIO_LIA less segregated default mode and dorsal attention networks was correlated with poorer cognitive performance. C_LI
On the Selectivity of Heparan Sulfate Recognition by SARS-CoV-2 Spike Glycoprotein.

SARS-CoV-2 infects human cells through its surface spike glycoprotein (SgP), which relies on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the ACE2 receptor. Targeting this process could lead to inhibitors of early steps in viral entry. Screening a microarray of 24 HS oligosaccharides against recombinant S1 and receptor-binding domain (RBD) proteins led to identification of only eight sequences as potent antagonists; results that were supported by detailed dual-filter computational studies. Competitive studies using the HS microarray suggested almost equivalent importance of IdoA2S-GlcNS6S and GlcNS3S structures, which were supported by affinity studies. Exhaustive virtual screening on a library of >93â¯000 sequences led to a novel pharmacophore with at least two 3-O-sulfated GlcN residues that can engineer unique selectivity in recognizing the RBD. This work puts forward the key structural motif in HS that should lead to potent and selective HS or HS-like agents against SARS-CoV-2.
Low Cardiopulmonary Toxicity With Use of IMRT When Delivering Postoperative Radiation Therapy (PORT) in Patients With NSCLC.

Purpose/Objective(s) The role of PORT for patients with resected stage IIIA (N2) NSCLC is controversial. Recently, the Phase III LungART trial reported a significant improvement in mediastinal control with PORT but failed to show an overall survival (OS) benefit, due in part to cardiopulmonary (CP) toxicity (7% early and 20% late grade (G) 3-5). However, LungART employed 3D conformal radiotherapy (3D-CRT) in 90% of patients as well as elective treatment of mediastinal nodal stations. We evaluated the risk of CP toxicity associated with use of postoperative IMRT for this population. Materials/Methods We conducted a retrospective study of consecutive patients with NSCLC treated with postoperative IMRT between 2008 and 2019. Patients were eligible if they were found to have incidental pN2 or an R1/2 resection. Targets of PORT for pN2 were bronchial stump, ipsilateral hilum, and involved mediastinal station(s). The primary objective was incidence of CTCAE (v4) G3+ CP toxicities. Secondary objectives were major adverse cardiac events (MACE), defined as cardiac death, myocardial infarction, coronary revascularization or hospitalization due to heart failure; disease-free survival (DFS); and OS. Cumulative incidence and Kaplan-Meier method were used as appropriate. Results 73 patients received PORT with IMRT. Median follow-up was 54 months. Median age at diagnosis was 65 years (range 36 - 81); 33 patients (45%) had pre-existing cardiovascular disease and 48 (65.8%) were current/former smokers. 50 patients had pN2 disease and 23 patients had R1/R2 resection. Among patients with pN2, the median number of involved mediastinal nodes was 1 (range 1 – 12). All patients with pN2 and 70% of patients with R1/R2 resection received chemotherapy, the majority of which was sequential (n = 52, 71.2%). Median RT dose was 54 Gy (range 45 – 66 Gy) in 27 fractions for patients with pN2 and 59.4 Gy (range 45 – 66 Gy) in 30 fractions for patients with R1/R2 resection. 3-year cumulative incidence of G3+ CP toxicity was 2.7%, with an overall incidence of 6.8% (5 events in 73 patients). The rate of G3+ CP toxicity in patients with pN2 was 8%. Three patients developed ≥1 MACE: one died of a cardiac arrest and two underwent coronary revascularization. Two of these patients had a history of coronary artery disease. Two episodes of G3+ toxicity involved valve replacements in patients with pre-existing valvular disease. 3-year DFS was 51.4% (95% CL 46.9 – 55.1%). Two patients with pN2 developed mediastinal failures. 3-year OS was 62.3% (95% CL 50.2 – 74.4%). Conclusion PORT for pN2 NSCLC using IMRT and no elective nodal irradiation is associated with a low rate of G3+ CP toxicity in patients with pN2, comparable to the chemotherapy only arm of the LungART trial. Our data suggest that highly conformal radiation techniques should be prospectively assessed for their potential to translate the known local control benefit of PORT into a survival advantage.