cssi/SciSciGPT-SciSciNet huggingface dataset:
Mitogen-activated protein kinase is involved in the progesterone-mediated induction of baboon glycodelin.

In the human and non-human primate the major secretory product of the uterine glandular epithelial cells is glycodelin. The expression of glycodelin is associated with elevated progesterone levels as its production peaks during the late luteal phase of the menstrual cycle and in early pregnancy. Consistent with our previous studies, we found that the majority of the progestin responsiveness of the baboon glycodelin promoter was retained in the −20/+48 region, a region devoid of progestin- and Sp1-response elements. Using serial 5′ and 3′ deletions of 10 basepairs of the promoter within the pGL3Basic vector, we identified the 5′ and 3′ limits required for progestin responsiveness as −22 and +18, respectively. When the same regions were cloned into the pGL3Promoter vector, a construct that contains the heterologous SV40 promoter, progestin did not enhance expression. Mutation of the DNA binding domain of the progesterone receptor, which disrupts its ability to activate the progesterone response element, does not obliterate its ability to induce expression via the baboon glycodelin promoter. Inhibitors of protein tyrosine kinases, genistein and AG18, blocked the progestin-mediated induction as did an inhibitor of MEK, PD98059, but not an inhibitor of p38 MAP kinase, SB202190. These findings imply that glycodelin induction in response to progestins involves a nongenomic mechanism through the ERK1/2 branch of the MAP kinase pathway. The ultimate target may be a factor involved in the initiation of glycodelin gene transcription.
The structure of cerium orthophosphate, a synthetic analogue of monazite

The crystal structure of CePO4 has been determined by modern X-ray crystallographic techniques. The unit cell is monoclinic (space group P21n) with a = 6.7777(3), b = 6.993(3), c = 6.445(3) A, and β = 103.54(4)°. The final least-squares refinement yielded R = 0.0276, and Rw = 0.0280. The structure is made up of irregular 9-coordinated cerium atoms linked together by distorted tetrahedral phosphate groups. Comparisons with previous structural determinations of naturl monazites are made. A potential application of the lanthanide orthophosphates as a nuclear waste matrix material is briefly discussed.
Method for evaluating kinetic stability of petroleum disperse systems

A method was developed for varying the ratio of paraffinic/naphthenic and aromatic hydrocarbons in petroleum disperse systems by introducing a model dispersion medium and for noting the dynamics of change of petroleum disperse system composition in a triangular diagram. Data for the construction of the system phase equilibrium curves were derived and the phase equilibrium of atmospheric resids, cracked tars, and pyrolysis tars was evaluated. Disruption of phase equilibrium upon introducing a precipitant led to coagulation of the asphaltenes and their separation from the deasphalted product phase in precipitate form. The method can be used in determining the quantity of precipitant required to achieve the necessary depth of deasphalting or to determine deasphalting depth with a given precipitant consumption.
DIAGNOSING PROTRACTED SUBMASSETERIC ABSCESS: THE ROLE OF COMPUTED TOMOGRAPHY

Because of its anatomical location, the submasseteric abscess mimics a parotitis. This is particularly true when the usual dental source of the infection is not present. A thorough medical history and clinical examination as well as computed tomography are important tools in the differential diagnosis.
Parent report of community psychiatric comorbid diagnoses in autism spectrum disorders.

We used a national online registry to examine variation in cumulative prevalence of community diagnosis of psychiatric comorbidity in 4343 children with autism spectrum disorders (ASD). Adjusted multivariate logistic regression models compared influence of individual, family, and geographic factors on cumulative prevalence of parent-reported anxiety disorder, depression, bipolar disorder, and attention deficit/hyperactivity disorder or attention deficit disorder. Adjusted odds of community-assigned lifetime psychiatric comorbidity were significantly higher with each additional year of life, with increasing autism severity, and with Asperger syndrome and pervasive developmental disorder—not otherwise specified compared with autistic disorder. Overall, in this largest study of parent-reported community diagnoses of psychiatric comorbidity, gender, autistic regression, autism severity, and type of ASD all emerged as significant factors correlating with cumulative prevalence. These findings could suggest both underlying trends in actual comorbidity as well as variation in community interpretation and application of comorbid diagnoses in ASD.
Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cε and selenoprotein thioredoxin reductase

Selenium prevents cancer in some cases but fails to do so in others. Selenium's failure in this respect may be due to the development of resistance to its chemopreventive actions. Selenocompounds induce a variety of cancer-preventive actions in tumor cells, but these actions may be limited by the low concentrations of free selenocompounds able to reach cells from the plasma. Therefore, we have sought to identify the chemopreventive action requiring the lowest concentration of the redox-active form of selenium, methylseleninic acid (MSA). At submicromolar concentrations, MSA inhibited the malignant transformation of RWPE-1 prostate epithelial cells. In contrast, in already transformed prostate cancer cells, selenium in the micromolar range was required to inhibit cell growth and invasion and to induce apoptosis. The role of protein kinase C (PKC) in these cellular processes, especially the moderately selenium-sensitive PKCepsilon, was demonstrated using PKC-specific inhibitors and small interfering RNA. PKCepsilon levels inversely correlated with cellular sensitivity to MSA. An over-expression of PKCepsilon minimized MSA-induced inhibition of RWPE-1 cell transformation and induction of apoptosis. Thioredoxin reductase (TR), a selenoprotein, reversed the MSA-induced inactivation of PKC isoenzymes. High TR expression in advanced prostate cancer cells correlated with resistance to MSA. Furthermore, inhibition of TR by its specific inhibitor, auranofin, resulted in increased sensitivity of prostate cancer cells to MSA. Collectively, these results suggest that the cancer-preventive actions of selenium may be negated both by an over-expression of PKCepsilon, which is a redox-sensitive target for MSA, and by the selenoprotein TR, which reverses PKC sulfhydryl redox modification.
A hybrid computational model for phagocyte transmigration

Phagocyte transmigration is the initiation of a series of phagocyte responses that are believed important in the formation of fibrotic capsules surrounding implanted medical devices. Understanding the molecular mechanisms governing phagocyte transmigration is highly desired in order to improve the stability and functionality of the implanted devices. A hybrid computational model that combines control theory and kinetics Monte Carlo (KMC) algorithm is proposed to simulate and predict phagocytes responses at molecular level. In order to mimic various biological knockout experiments, a general external control scenario is designed. The stochastic nature inherent to phagocyte transmigration is captured by KMC. A new formula is derived to calculate the transition rates as inputs to KMC. This formulation might quantify biological interactions in a general manner which is beyond the scope of the traditional chemical reaction kinetics.
Mastery and Frequency of Managerial Behaviors Relative to Sub-unit Effectiveness

This research was undertaken in response to a review which called for a behavioral approach to the study of leadership. The subjects of the study were the managers of sub-units in a hospital. Eleven managerial behaviors were assessed using their subordinates as untrained observers, and behaviorally-anchored questionnaires. Effectiveness was assessed by industrial engineering measures of performance and employee attitude. The results indicate that managers of sub-units of high and low morale and/or performance exhibited significantly different levels of mastery of managerial behaviors. In contrast, no differences in frequency of managerial behaviors were observed for either high or low morale units, and only one managerial behavior was observed to be significantly more frequent for managers of high and low performing units. Whereas, higher frequency of managerial behaviors was found, overall, to be associated with low and not high performing sub-units.
GCF2/LRRFIP1 represses tumor necrosis factor alpha expression.

Tumor necrosis factor alpha (TNF-α) is an important mediator of inflammation, apoptosis, and the development of secondary lymphoid structures. Multiple polymorphic microsatellites have been identified in and around the gene, and there are also multiple single-base pair biallelic polymorphisms in the introns and promoter. The TNF-α −308 promoter polymorphism is a G-to-A transition which has been statistically associated with various autoimmune disorders. Some studies have found that it may directly mediate the increased transcription of TNF-α in some circumstances. This study characterizes proteins interacting at the polymorphic promoter site. Affinity purification of binding proteins and confirmatory chromatin immunoprecipitation assays were used to identify the proteins. Electrophoretic mobility shift analyses and surface plasmon resonance were used to define binding characteristics. Proteins interacting at this site include GCF2/LRRFIP1 and Ets-1. GCF2/LRRFIP1 appears to act as a repressor and occupies the −308 site in cells that do not make TNF-α. Cells competent to produce TNF-α have Ets-1 bound to the −308 promoter site. Active transcription is accompanied by NF-κB and c-Jun binding to the proximal promoter. Thus, dynamic changes on the TNF-α promoter, particularly at the −308 site, accompany the transition from repressed to active transcription. GCF2/LRRFIP1 is the first TNF-α repressor identified.
Maintaining remote services and resources over the Internet and other networks

Many organizations are discovering the need to protect themselves with isolation routers, firewalls, and other technologies. Simultaneously they are collaborating more and more with external organizations. When local services and resources must be shared externally, problems arise. Servers at remote locations can provide copies of local services and resources. Offering services and resources via remote servers means that the home organization must also control access to these services and resources. This paper defines a remote node architecture (RNA) that can house multiple services and resources. The RNA provides secure communications between the remote node and the home organization for all services and resources, and between the RNA services and resources and the users thereof.
Teaching to the Beat: The Pedagogical Value of Music Videos:

The use of art forms to add value to the marketing curriculum is receiving increasing attention. Overlooked, however, has been one of the most popular and ubiquitous of contemporary art forms—the music video. This article examines the pedagogical value of the country music video in communicating and reinforcing core American cultural values presented in a consumer behavior course. Results indicate that music videos are effective in influencing student's attitudes toward the course and in producing a greater understanding of the construct of culture.
Mechanism for Removal of Tumor Necrosis Factor Receptor 1 from the Cell Surface by the Adenovirus RIDα/β Complex

Proteins encoded in adenovirus early region 3 have important immunoregulatory properties. We have recently shown that the E3-10.4K/14.5K (RIDα/β) complex downregulates tumor necrosis factor receptor 1 (TNFR1) expression at the plasma membrane. To study the role of the RIDβ tyrosine sorting motif in the removal of surface TNFR1, tyrosine 122 on RIDβ was mutated to alanine or phenylalanine. Both RIDβ mutations not only abolished the downregulation of surface TNFR1 but paradoxically increased surface TNFR1 levels. RID also downregulates other death receptors, such as FAS; however, surface FAS expression was not increased by RIDβ mutants, suggesting that regulation of TNFR1 and that of FAS by RID are mechanistically different. In the mixing experiments, the wild-type (WT) RID-mediated TNFR1 downregulation was partially inhibited in the presence of RIDβ mutants, indicating that the mutants compete for TNFR1 access. Indeed, an association between RIDβ and TNFR1 was shown by coimmunoprecipitation. In contrast, the mutants did not affect the WT RID-induced downregulation of FAS. These differential effects support a model in which RID associates with TNFR1 on the plasma membrane, whereas RID probably associates with FAS in a cytoplasmic compartment. By using small interfering RNA against the μ2 subunit of adaptor protein 2, dominant negative dynamin construct K44A, and the lysosomotropic agents bafilomycin A1 and ammonium chloride, we also demonstrated that surface TNFR1 was internalized by RID by a clathrin-dependent process involving μ2 and dynamin, followed by degradation of TNFR1 via an endosomal/lysosomal pathway.
A new technique to handle local minimum for imperfect potential field based motion planning

Random walk like techniques have been used to help potential field based motion planning techniques to escape from local minimum configurations. However, the associated cost can be large for some applications which require smoothing to take out the incoherent motion steps that are discovered through the random walks. In this paper the authors present a new technique to reduce or eliminate the need for random walks while improving performance. The authors discuss characteristics in application which can be a potential candidate to benefit from this new technique.
Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression

Survivin is overexpressed in most human cancers, including pancreatic adenocarcinoma. Expression of survivin is regulated by specificity protein (Sp) proteins and related to resistance to radiation therapy. Tolfenamic acid induces Sp protein degradation in several cancer cell lines. The purpose of this study is to investigate whether tolfenamic acid inhibits survivin expression and sensitizes pancreatic cancer cells/tumor to radiotherapy. Panc1 and L3.6pl cells have been used to study the effect of radiation on survivin expression and to investigate the efficacy of tolfenamic acid in enhancing the response to radiation therapy. In addition, an orthotopic model for human pancreatic cancer has been used to confirm the efficacy of tolfenamic acid to enhance tumor response to radiation in vivo. Pancreatic cancer cell lines express variable levels of survivin mRNA/protein, which correlate with their radiosensitivity. Radiation increased survivin promoter activity and protein expression in Panc1 and L3.6pl cells and tolfenamic acid inhibited both constitutive and radiation-induced survivin protein expression and enhanced the response of pancreatic cancer cells to radiation therapy. In vivo studies show that tolfenamic acid enhanced the radiation-induced apoptosis associated with decreased survivin expression in tumors and this correlates with the enhanced response of these tumors to the radiation. Thus, tolfenamic acid significantly enhances pancreatic cancer cells/tumor response to radiation therapy. The underlying mechanism includes tolfenamic acid-induced degradation of Sp proteins, which in tumor decreases expression of the Sp-dependent antiapoptotic protein survivin. These preclinical data suggest that tolfenamic acid has the potential to increase the response of pancreatic adenocarcinoma to radiation therapy.
Pre-processing input data to augment fault tolerance in space applications

Today’s advanced science applications often process huge volumes of data in real-time under extreme ambiances such as in spacecrafts and surveillance equipment. Faults manifesting in this raw data may corrupt the input given to these applications, causing flawed results. Hence we show that highly significant improvements in application reliability and precision can be obtained if the data is proactively preprocessed, using statistical analysis of input for possible recovery from the bit errors at input. In this paper we implement application-specific algorithms for preprocessing the input datasets for two major space applications. The Next-Generation Space Telescope (NGST) and the Orbital Thermal Imaging Spectrometer (OTIS) are both
Earth field reference-motion tracking utilizing magneto-resistive sensors [human motion tracking]

The objective of this paper is to demonstrate the application of matrices in generating a three-dimensional stick figure from sampled magneto-resistive sensor readings. While conventional frame capture techniques offer at best post-analysis motion studies, three-dimensional stick figures may be rendered for real-time and post-analysis studies. An added benefit of rendering a three-dimensional stick figure is the flexibility in changing the observer's perspective.
Selenium in Health and Disease

One of the more exciting effects of selenium on health is selenium’s anticarcinogenic effect against experimentally induced cancer in several animal systems.
Natural history of age-related lobular involution and impact on breast cancer risk

Age-related lobular involution (LI) is a physiological process in which the terminal duct lobular units of the breast regress as a woman ages. Analyses of breast biopsies from women with benign breast disease (BBD) have found that extent of LI is negatively associated with subsequent breast cancer development. Here we assess the natural course of LI within individual women, and the impact of progressive LI on breast cancer risk. The Mayo Clinic BBD cohort consists of 13,455 women with BBD from 1967 to 2001. The BBD cohort includes 1115 women who had multiple benign biopsies, 106 of whom had developed breast cancer. Within this multiple biopsy cohort, the progression of the LI process was examined by age at initial biopsy and time between biopsies. The relationship between LI progression and breast cancer risk was assessed using standardized incidence ratios and by Cox proportional hazards analysis. Women who had multiple biopsies were younger age and had a slightly higher family history of breast cancer as compared with the overall BBD cohort. Extent of LI at subsequent biopsy was greater with increasing time between biopsies and for women age 55 + at initial biopsy. Among women with multiple biopsies, there was a significant association of higher breast cancer risk among those with involution stasis (lack of progression, HR 1.63) as compared with those with involution progression, p = 0.036. The multiple biopsy BBD cohort allows for a longitudinal study of the natural progression of LI. The majority of women in the multiple biopsy cohort showed progression of LI status between benign biopsies, and extent of progression was highest for women who were in the perimenopausal age range at initial biopsy. Progression of LI status between initial and subsequent biopsy was associated with decreased breast cancer risk.
Use of Decision Assistance Curves in Advanced Warrant Analysis for Indirect Left-Turn Intersections

This paper develops decision assistance curves (DACs) to compare delay-based performance measures for three indirect left-turn (ILT) intersections—median U-turn, continuous-flow intersection, and jughandle—relative to a conventional signalized intersection. The DACs consist of two graphical tools: (a) a DAC classifier and (b) two sets of DAC contours. DAC classifier plots are used to select the intersection type that produces the minimum system average delay for a specified main and cross-street volume configuration. DAC contour plots are used to estimate the system average delay difference between a chosen ILT and a conventional signalized intersection and to estimate the increase in average delay compared with a conventional signalized intersection for the movement most negatively affected. These tools can be used by planners, engineers, or other decision makers to identify visually the intersection type that provides the least average system delay under given volume conditions and estimated trade-offs ...
Low-Temperature Flexibility of Synthetic Elastomers Effect of Aviation Gasolines

Abstract A tensiometer can be used to measure the stiffness of rubber stocks; accurate data are secured which lend themselves to a quantitative interpretation of the effect of low temperatures on any compound. Where changes in the sensitivity to flexing of thin rubber sections are important, such data, represented by curves of temperature vs. flexibility, seem more important than durometer changes and bend-brittle points. The compounding practice of high plasticizer does not in itself provide low-temperature flexibility where fuel immersion and ensuing plasticizer extraction are conditions of service. Tests designed to evaluate low-temperature flexibility and freeze resistance which utilize organic liquids as temperature conditioners must be double-checked to ensure that the cooling medium is not exerting its own specific effect on the stocks. Graphs indicate the influence of aviation fuels on low-temperature resistance; it has been experimentally proved by the same method that acetone has a similar effec...
On the Dominance of Attitude Emotionality

Many situations in our lives require us to make relatively quick decisions as whether to approach or avoid a person or object, buy or pass on a product, or accept or reject an offer. These decisions are particularly difficult when there are both positive and negative aspects to the object. How do people go about navigating this conflict to come to a summary judgment? Using the Evaluative Lexicon (EL), we demonstrate across three studies, 7,700 attitude expressions, and nearly 50 different attitude objects that when positivity and negativity conflict, the valence that is based more on emotion is more likely to dominate. Furthermore, individuals are also more consistent in the expression of their univalent summary judgments when they involve greater emotionality. In sum, valence that is based on emotion tends to dominate when resolving ambivalence and also helps individuals to remain consistent when offering quick judgments.
Abnormal vibration fault diagnosis caused by the blades of steam turbine

Addressing from the abnormal vibration fault diagnosis of 300MW unit shafting,it researched on the vibration characteristic and vibration treatment of the low-pressure rotor after changing the blades. The field dynamic balancing method offered an effectual reference for how to solve the shafting vibration fault problems of this type of unit.
MRI and morphological observation in C6 glioma model rats and significance

Objective To establish stable and reliable rat C6 glioma model,and to perform MRI dynamic observation and pathomorphological observation in model animal brain,and to provide experimental basis for pharmaceutical research on anti-glioma drugs.Methods The C6 glioma cells were cultured and 20 μL cultural fluid containing 1×106 C6 cells was sterotactically implanted into the left caudate nuclei in 10 male Wistar rats,respectively.The changes in the behavior of the rats after implantation were observed and recorded.MRI dynamic scanning was performed in 10 rats 2,3 and 4 weeks after implantation and the brain tissues were taken for general and pathological examination when the 10 rats were naturally dead.The survival period of tumor-bearing rats was calculated.Results 2 weeks after implantation the rats showed decreased activities and food intake,fur lackluster,and conjunctival congestion and so on;3 weeks later,some rats appeared nerve symptoms such as body twitch,body hemiplegy,body distortion,rotation and so on.All the 10 rats died in 8-30 d.The median surrival period of the tumor-bearing rats was 18 d,the average survival period was(18.3±7.3) d.The pathological examination showed that the tumor cells were arranged irregularly and closely and karyokinesis was easy to see;tumor vascular tissue proliferation and tumor invasive growth into surrounding normal tissues were found.The expression of glial fibrillary acidic protein(GFAP) was positive in the tumors.Conclusion A stable animal model of intracranial glioma is sucessfully established by stereotactic implantation of C6 cells into the rat caudate nucleus.The results of MRI dynamic observation and pathohistological observation on the model animal brain tissue.can provide experimental basis for selecting the appropriate time window to perform the pharmaceutical research on anti-glioma drugs.
Design and implementation of redundancy for dual-NIC

In order to protect against possible network node or link failure in embeded network environment, well-planed fault recovery methods are necessary to achieve higher reliability of network communication. In this paper, we present a method based on dual NIU redundancy. The proposed method consists of the fault detection method and fault recovery method. The fault detection method uses link status test and loopback test in IEEE802.3 Ethernet. The fault correction method takes charge of correcting the activated NIU's fault by switching to the standby NIU. Implementation of the proposed method can improve the reliability of communication effectively.
Epidemiological investigation on healthy lifestyle and body mass index of the rural women of Huating Town

Objective: To understand the healthy lifestyle of the rural women of Huating Town, Jiading District, to provide a basis for carrying out health intervention. Method: Five hundred-one women in Lianhua village, Huating town were selected to investigate on healthy lifestyle with the self-made questionnaire by cluster sample. Result: The rural women drinking rate was 9.38% in the past three months, and there was the statistic difference among different education level in drinking rate (x 2 = 7.037, P=0.030). The smoking rate was 0.60%, the rate of eating meat and vegetables was 67.27%, idle time to participate in exercise accounted for 51.50%. Of all participates, there was 182 (36.32%) who sit-in daily more than six hours, and 41 (8.18%) who sit-in daily more than nine hours. The overweight and obesity accounted for 34.33% and 8.98% respectively. The eating habits, meditation time, participating in physical activity and BMI index were statistical difference among different age groups, education level and different resident places. Conclusion: The healthy lifestyle of the local women is not optimistic, and the overweight and obesity problem is more serious.
Ventrikelseptumdefekt nach Herzinfarkt

Die Ruptur des Ventrikelseptums stellt eine seltene und ausgesprochen ernste Komplikation des Herzinfarktes dar. Die Fortschritte in der perioperativen Kreislaufunterstutzung, dem Myokardschutz und der Operationstechnik haben die chirurgischen Ergebnisse dieser in fruheren Jahren beinahe immer todlichen Herzerkrankung entscheidend verbessert.
Human Problem-Solving: A Systems Cybernetic View from the Top

In spite of the shift in behavioral science towards the study of cognition, theories of complex human behavior still tend to be highly restrictive. Piagetian structuralism provides a major alternative, but it fails to make contact with more specialized theories in artificial intelligence, cognitive psychology, and individual differences measurement. The structural learning theory helps to bridge this gap. In my paper I will discuss the interrelationships which exist among content, cognition, and individual differences and the constraints which these interrelationships impose on the form of any comprehensive theory of human problem-solving.
Principle component feature detector for motor cortical control

Principle component analysis (PCA) was performed on recorded neuronal action potentials from neural ensembles in rat's motor cortex when the rat was involved in a closed-loop real-time brain machine interface (BCI). The implanted rat was placed in a conditioning chamber, but freely moving, to decide which one of the two paddles should be activated to shift the light to the center. It is found that the principle component feature vectors revealed the importance of individual neurons and their temporal dynamics in relation to the intention of activating either left or right paddle. In addition, the first principle component feature has much higher discriminative capability than others although it represents only a few percentage of the total variance. Using the first principle component with the Bayes classifier achieved 90% classification accuracy, which is comparable with the accuracy obtained by a more sophisticated high performance support vector classifiers.
Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation.

Actin-depolymerizing factor (ADF)/cofilin and actin-interacting protein 1 (AIP1), also known as WD-repeat protein 1 (WDR1), are conserved among eukaryotes and play critical roles in dynamic reorganization of the actin cytoskeleton. AIP1 preferentially promotes disassembly of ADF/cofilin-decorated actin filaments but exhibits minimal effects on bare actin filaments. Therefore, AIP1 has been often considered to be an ancillary co-factor of ADF/cofilin that merely boosts ADF/cofilin activity level. However, genetic and cell biological studies show that AIP1 deficiency often causes lethality or severe abnormalities in multiple tissues and organs including muscle, epithelia, and blood, suggesting that AIP1 is a major regulator of many biological processes that depend on actin dynamics. This review summarizes recent progress in studies on the biochemical mechanism of actin filament severing by AIP1 and in vivo functions of AIP1 in model organisms and human diseases.
Left Ventricular Torsion Shear Angle Volume Approach for Noninvasive Evaluation of Diastolic Dysfunction in Preserved Ejection Fraction

BackgroundAccurate noninvasive diagnostic tools for evaluating left ventricular (LV) diastolic dysfunction (LVDD) are limited in preserved LV ejection fraction. We previously proposed the relations...
Grounded Dependability: Leading with Faithfulness

An implicit requirement of successful organization outcomes is the faithfulness of both leaders and followers. David’s faithfulness to the faithless King Saul becomes a helpful biblical example. This chapter will analyze a biblical understanding of faithfulness and its application to organizational leadership. This analysis will show faithfulness to be not only a characteristic of God but also an expression of one’s standing with God, with others, and with one’s own adherence to the beliefs that govern their life. From the covenant of the Old Testament to the authenticity of Greek understanding to the endurance under suffering of the New Testament, this characteristic has several important applications to contemporary organizations. These applications are applied to a contemporary example of funeral directors.
Pompe disease treatment with twice a week high dose alglucoside alfa in a patient with severe dilated cardiomyopathy.

Abstract There is limited information regarding ideal dosage of alglucoside alfa in patients with Infantile Onset Pompe Disease (IOPD). The U.S. Food and Drug Administration approved alglucoside alfa at dosing of 20 mg/kg every other week, but there are small studies and case reports suggesting that dosing higher than this leads to improved ventilator free survival and development without adverse events. We review the clinical course and short term clinical outcomes one year following late diagnosis of IOPD in a 3 month old who presented severely affected and was treated with 40 mg/kg twice a week for 21 infusions until six months of age then transitioned to 40 mg/kg/week. The patient responded well to 40 mg/kg twice a week treatment without adverse reactions and significant clinical improvement.
Concerning the Nature of Positive Law

Legal philosophy, however, does not exhibit much evidence of having benefited from the strategic vantage-point thus conferred upon it. This is apparent in many essays concerning the nature of positive law, where it is difficult, if not impossible, to detect any deeper insights than the ancient philosophers had. Instead we are apt to find narrow interpretations by specialists interested in a particular phase of law. Many legal philosophers believe, of course, that the term "positive law" is very ambiguous. They have usually been content to state meanings, ending their analysis with the implication, "You may take your choice." Thus, whatever Kelsen's dialectic actually means, he argues that (a) the definition of positive law is purely a matter of taste and (b) various legal philosophers have had different tastes in this regard-hence there is no better or "objective" determination of the issue. This view is a reflection of the theory that definition is "nominal." 1 On the other hand, the common sense view is that so far as an inquiry is empirical, the definitions used must represent the facts. This approach cannot be dismissed as the common man's naivete. When a scientist defines his terms, he, too, implies that his definitions are descriptive. There is, accordingly, a tentativeness regarding his definitions since his knowledge of the facts is limited and changing. But he certainly intends to represent the existing knowledge in his definitions. His definitions can therefore be challenged as incorrect or inadequate representations of the facts. This same responsibility to the relevant facts should also characterize the definition of positive law. That view is rendered more persuasive when one observes that nominal definitions of positive law stimulate the use of logical and analytical methods and discourage persevering study of the facts with
Water Sustainability in a Warming World: A Paleo-Perspective

As Earth is warmed by fossil fuel CO 2 , the allocation of water for agricultural use will become an ever larger issue. The greater demand to be created by a growing population will be complicated by shifts in the geographic pattern of precipitation. These shifts will have the most serious consequences in Earth's vast dry lands. The global climate models used to predict these shifts while in agreement that the tropics will become wetter and extra tropics will become drier, disagree with one another regarding the magnitude and geographic pattern of these changes. The changes in precipitation associated with the last cycle of glaciation and recent Little Ice Age have much to offer in this regard. The key archives of this information are the size histories of closed-basin lakes and oxygen isotope record in stalagmites. These records serve not only as targets for validating global climate models but also as direct indicators as to what might be in store for us as the planet warms. In addition to the planet-wide warming, the record offers insight into the impacts of the differential warming, which the Northern Hemisphere will experience as the globe warms. If nothing else, the record warns us that the changes in store for us will be quite large!
Cross-Sectional Echocardiography in Evaluation of Patients with Discrete Subvalvular Aortic Stenosis

Ten patients with discrete subvalvular aortic stenosis were examined using a real-time, high resolution, cross-sectional echocardiographic sector scanner. There were two patients with a thin discrete subvalvular membrane, group I; five patients with a more extensive area of subvalvular narrowing, group II; and three patients in whom a residual area of outflow tract obstruction remained following prior surgical revision, group III. In the two patients with a thin obstructive membrane, group I, two distinct linear echoes were observed in the outflow tract. These echoes were located immediately beneath the aortic valve, were not continuous with the walls of the outflow tract and showed some dynamic motion during the cardiac cycle. In four of five patients with diffuse outflow tract narrowing, group II, a relatively extensive area of inward bowing of both anterior and posterior margins of the outflow tract was noted. In the fifth case, a prominent localized, shelf like increase in thickness of the basal portion of the muscular septum along with a corresponding echo projecting anteriorly from the mid portion of the anterior mitral leaflet was present. The septal thickness in this case at the level of the free edge of the mitral valve, along with the septal posterior wall ratio was normal.
Arterial Complications in Patients with Cancer

Complications of peripheral arterial disease in cancer patients are associated with increased morbidity and mortality. Medical management with modification of vascular risk factors remains the first line of treatment for cancer patients with arterial occlusive disease. Endovascular or surgical revascularization is indicated for patients who have critical limb ischemia or disabling claudication symptoms. In this article, we review the management of peripheral arterial disease in cancer patients, and present a series of common and rare case examples of arterial complications that can occur during or after oncologic therapy.
Coupled Nd and B ′ spin ordering in the double perovskites Nd 2 Na B ′ O 6 ( B ′ = Ru , Os)

We present a neutron powder-diffraction study of the monoclinic double perovskite systems Nd${}_{2}$Na${B}^{\ensuremath{'}}$O${}_{6}$ (${B}^{\ensuremath{'}}=\text{Ru}$, Os), with magnetic atoms occupying both the $A$ and ${B}^{\ensuremath{'}}$ sites of the ${A}_{2}B{B}^{\ensuremath{'}}{\text{O}}_{6}$ structure. Our measurements reveal coupled spin ordering between the Nd and ${B}^{\ensuremath{'}}$ atoms with magnetic transition temperatures of 14.3(1) K for Nd${}_{2}$NaRuO${}_{6}$ and 16.2(2) K for Nd${}_{2}$NaOsO${}_{6}$. There is a type-I antiferromagnetic structure associated with the Ru and Os sublattices, with the ferromagnetic planes stacked along the $c$ axis and [110] direction respectively, while the Nd sublattices exhibit complex, canted antiferromagnetism with different spin arrangements in each system.
Transanal Total Mesorectal Excision: Single-Surgeon Approach

Transanal total mesorectal excision (taTME) has emerged as an additional minimally invasive surgical approach for management of benign and malignant disease of the rectum. It has been demonstrated to be safe and effective, with potential to circumvent some of the challenges inherent in open, laparoscopic, and robotic approaches. Widespread adoption of the taTME approach may be tempered by the demanding technical nature of the procedure and lack of long-term functional and oncologic outcomes, although literature to date has demonstrated significant promise. While simultaneous abdominal and perineal dissection performed with a two-surgeon approach can facilitate a shorter operative duration, a single-surgeon approach has unique advantages as well and will be the focus of this chapter.
Fiber-Optic Silicon Fabry-Perot Interferometric Bolometer: The Influence of Mechanical Vibration and Magnetic Field

Plasma radiation plays an important role in the operation and control of magnetic confinement fusion and is typically measured by bolometers. Here, we study the influence of mechanical vibration and magnetic field, which are typically present in magnetic confinement fusion devices, on the performance of a fiber-optic bolometer (FOB) based on silicon Fabry-Perot interferometer (FPI) demodulated by a scanning diode laser. It is found that both the vibration and magnetic field could cause large noise due to the birefringence of the silicon FPI. To mitigate the birefringence effects, we demonstrated two effective methods: polarization maintaining FOB and polarization scrambling. We show that two methods can be effective in mitigating the effect caused by the sensor birefringence: (1) replacing the regular single-mode fiber in the FOB system with polarization-maintaining fiber and (2) using a polarization scrambler after the laser source. For both methods, no significant increase in the noise was observed in the vibration and magnetic field tests. Our research highlights the importance of the polarization management for the FOB systems toward their practical applications in magnetic-confinement fusion systems.
Defects in syntabulin-mediated synaptic cargo transport associate with autism-like synaptic dysfunction and social behavioral traits

The formation and maintenance of synapses require long-distance delivery of newly synthesized synaptic proteins from the soma to distal synapses, raising the fundamental question of whether impaired transport is associated with neurodevelopmental disorders such as autism. We previously revealed that syntabulin acts as a motor adapter linking kinesin-1 motor and presynaptic cargos. Here, we report that defects in syntabulin-mediated transport and thus reduced formation and maturation of synapses are one of core synaptic mechanisms underlying autism-like synaptic dysfunction and social behavioral abnormalities. Syntabulin expression in the mouse brain peaks during the first 2 weeks of postnatal development and progressively declines during brain maturation. Neurons from conditional syntabulin-/- mice (stb cKO) display impaired transport of presynaptic cargos, reduced synapse density and active zones, and altered synaptic transmission and long-term plasticity. Intriguingly, stb cKO mice exhibit core autism-like traits, including defective social recognition and communication, increased stereotypic behavior, and impaired spatial learning and memory. These phenotypes establish a new mechanistic link between reduced transport of synaptic cargos and impaired maintenance of synaptic transmission and plasticity, contributing to autism-associated behavioral abnormalities. This notion is further confirmed by the human missense variant STB-R178Q, which is found in an autism patient and loses its adapter capacity for binding kinesin-1 motors. Expressing STB-R178Q fails to rescue reduced synapse formation and impaired synaptic transmission and plasticity in stb cKO neurons. Altogether, our study suggests that defects in syntabulin-mediated transport mechanisms underlie the synaptic dysfunction and behavioral abnormalities that bear similarities to autism.
The productivity of schools and other local public goods producers

Abstract I construct an agency model of local public goods producers in which households make Tiebout choices among jurisdictions in a world of imperfect information and costly residential mobility. I examine producers’ effort and rent under local property tax finance and centralized finance. I show that, if there are a sufficient number of jurisdictions, conventional local property tax finance can attain about as much productivity as a social planner with centralized finance can, even if the social planner is armed with more information than a real social planner could plausibly have. The key insight is that decentralized Tiebout choices make some information the social planner would need verifiable and other information unnecessary .
Wittgenstein (and his followers) on meaning and normativity

This paper questions the idea that Wittgenstein’s account of meaning as use requires an intrinsically normative understanding of this notion, and suggests instead that Wittgenstein is better understood as promoting a naturalistic view of meaning that undertakes an explanation based on non–semantic and non–normative facts of word–usage. It discusses the relevant positions of Kripke, Brandom and McDowell, all of whom are found to be united by the attempt to attribute to Wittgenstein a normative understanding of language that is not convincing. While language does exhibit normative properties that cannot be naturalized, the understanding speakers have of their own words is “a prima facie plausible candidate for naturalistic analysis.”
Post-translational Succinylation of Mycobacterium tuberculosis Enoyl-CoA Hydratase EchA19 Slows Catalytic Hydration of Cholesterol Catabolite 3-Oxo-chol-4,22-diene-24-oyl-CoA.

Cholesterol is a major carbon source for Mycobacterium tuberculosis (Mtb) during infection, and cholesterol utilization plays a significant role in persistence and virulence within host macrophages. Elucidating the mechanism by which cholesterol is degraded may permit the identification of new therapeutic targets. Here, we characterized EchA19 (Rv3516), an enoyl-CoA hydratase involved in cholesterol side-chain catabolism. Steady-state kinetics assays demonstrated that EchA19 preferentially hydrates cholesterol enoyl-CoA metabolite 3-oxo-chol-4,22-diene-24-oyl-CoA, an intermediate of side-chain β-oxidation. In addition, succinyl-CoA, a downstream catabolite of propionyl-CoA that forms during cholesterol degradation, covalently modifies targeted mycobacterial proteins, including EchA19. Inspection of a 1.9 A resolution X-ray crystallography structure of Mtb EchA19 suggests that succinylation of Lys132 and Lys139 may perturb enzymatic activity by modifying the entrance to the substrate binding site. Treatment of EchA19 with succinyl-CoA revealed that these two residues are hotspots for succinylation. Replacement of these specific lysine residues with negatively charged glutamate reduced the rate of catalytic hydration of 3-oxo-chol-4,22-diene-24-oyl-CoA by EchA19, as does succinylation of EchA19. Our findings suggest that succinylation is a negative feedback regulator of cholesterol metabolism, thereby adding another layer of complexity to Mtb physiology in the host. These regulatory pathways are potential noncatabolic targets for antimicrobial drugs.
Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair

The integrity and regulation of the nuclear lamina is essential for nuclear organization and chromatin stability, with its dysregulation being linked to laminopathy diseases and cancer. Although numerous posttranslational modifications have been identified on lamins, few have been ascribed a regulatory function. Here, we establish that lamin B1 (LMNB1) acetylation at K134 is a molecular toggle that controls nuclear periphery stability, cell cycle progression, and DNA repair. LMNB1 acetylation prevents lamina disruption during herpesvirus type 1 (HSV-1) infection, thereby inhibiting virus production. We also demonstrate the broad impact of this site on laminar processes in uninfected cells. LMNB1 acetylation negatively regulates canonical nonhomologous end joining by impairing the recruitment of 53BP1 to damaged DNA. This defect causes a delay in DNA damage resolution and a persistent activation of the G1/S checkpoint. Altogether, we reveal LMNB1 acetylation as a mechanism for controlling DNA repair pathway choice and stabilizing the nuclear periphery.