cssi/SciSciGPT-SciSciNet huggingface dataset:
Abstract POSTER-BIOL-1317: Releasing the brakes on ovarian cancer cell survival: epigenetic suppression of RGS10 in ovarian cancer chemoresistance

G-protein signaling pathways promote cell survival, which is aberrantly enhanced in chemoresistant ovarian cancer. Regulator of G-protein Signaling (RGS) proteins limit the strength of G-protein signaling, and therefore indirectly control cell survival. We have previously shown that RGS10 suppresses ovarian cancer cell growth and limits survival in the presence of cytotoxic chemotherapeutic drugs. Further, we have shown that RGS10 expression is suppressed in cell models of ovarian cancer chemoresistance, suggesting that ovarian cancer cells silence RGS10 expression to release the brakes on their growth and survival. However, the mechanisms governing RGS10 expression in ovarian cancer cells are poorly understood. In this study, we fully investigate the molecular mechanism of RGS10 suppression in ovarian cancer acquired chemoresistance, revealing key roles for epigenetic regulation by DNA hypermethylation and histone deacetylation. Pharmacological inhibition of DNA methyl-transferases (DNMTs) increases RGS10 expression in chemoresistant ovarian cancer cells, suggesting potential regulation by DNA methylation. Further, bisulfite sequencing analysis identified a region of the RGS10-1 promoter with significantly enhanced DNA methylation in chemoresistant A2780-AD cells relative to parental A2780 cells. More marked differences are observed in histone acetylation of the RGS10-1 promoter. Acetylated histone H3 associates with the RGS10-1 promoter was significantly lower in A2780-AD cells compared to parental cells, with a corresponding increase in histone deacetylase (HDAC) enzyme association. Further, both HDAC1 and DNMT1 exhibit aberrant association with RGS10 promoters in chemoresistant ovarian cancer cells. Knockdown of HDAC1 or DNMT1 expression, and pharmacological inhibition of DNMT or HDAC enzymatic activity, significantly increases RGS10 expression and cisplatin-mediated cell death. Finally, DNMT1 knock down decreases HDAC1 binding to the RGS10 promoter in chemoresistant cells, suggesting HDAC1 recruitment to RGS10 promoters requires DNMT1 activity. Our results suggest that HDAC1 and DNMT1 cooperatively contribute to the suppression of RGS10 during acquired chemoresistance and support inhibition of HDAC1 and DNMT1 as an adjuvant therapeutic approach to overcome ovarian cancer chemoresistance. Citation Format: Shelley Hooks, PhD. Releasing the brakes on ovarian cancer cell survival: epigenetic suppression of RGS10 in ovarian cancer chemoresistance [abstract]. In: Proceedings of the 10th Biennial Ovarian Cancer Research Symposium; Sep 8-9, 2014; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(16 Suppl):Abstract nr POSTER-BIOL-1317.
Ripples in a superconducting tidal pool

The behaviour of electrons in a metal is often compared to that of water in a pool. An empty pool is like a material that has all of its electrons removed. As electrons are "poured" into the metal, they first occupy the lowest energies available – the bottom of the pool – and eventually fill up to the Fermi energy, the top of the pool. At this point we no longer discuss electrons but quasiparticles. These are electrons that have modified properties due to their interactions within the material.
Blasts with abundant cytoplasmic granules: acute myeloid leukemia or granular acute lymphoblastic leukemia?

![Figure][1] A 63-year-old woman had a history of B-cell acute lymphoblastic leukemia (B-ALL). The pretreatment blasts showed no significant cytoplasmic granules (panel A; original magnification ×1000, Wright-Giemsa stained marrow aspirate smears) and were positive for CD19, CD22, CD10, CD34
mStroke: "Mobile Stroke"-Improving Acute Stroke Care With Smartphone Technology

Objective This study aimed to evaluate the effect of method and time of system activation on clinical metrics in cases utilizing the Stop Stroke (Pulsara, Inc.) mobile acute stroke care coordination application. Methods A retrospective cohort analysis of stroke codes at 12 medical centers using Stop Stroke from March 2013 to May 2016 was performed. Comparison of metrics (door-to-needle time [DTN] and door-to-CT time [DTC], and rate of DTN ≤ 60 minutes [goal DTN]) was performed between subgroups based on method (emergency medical service [EMS] versus emergency department [ED]) and time of activation. Effects were adjusted for confounders (age, sex, National Institutes of Health Stroke Scale [NIHSS] score) using multiple linear and logistic regression. Results The final dataset included 2589 cases. Cases activated by EMS were more severe (median NIHSS score 8 versus 4, P P Conclusions Incorporating real-time prehospital data obtained via smartphone technology provides unique insight into acute stroke codes. Activation of mobile electronic stroke coordination in the field appears to promote a more expedited and successful care process.
Aerosolized substance P protects against cigarette-induced lung damage and tumor development.

Both first-hand and second-hand [i.e. side-stream cigarette smoke (SSCS)] exposure to cigarette smoke is known to damage the lungs, alter the immune system, and predispose individuals to the development of emphysema and lung cancer. Previous work from these laboratories has demonstrated that administration of aerosolized substance P (SP) was capable of protecting the pulmonary and immune systems from damage due to environmental toxicants (e.g. hydrocarbon exposures). In the present study, the effects of SP on SSCS exposure were examined. Treatment of mice exposed to SSCS with aerosolized SP prevented pathological cellular and functional changes in the lung as reflected by prevention of damage to airway basement membranes/endothelial cells and preservation of normal airway dynamic compliance. Further, SP treatment reduced and/or prevented the occurrence of micronuclei formation in cells isolated from mice exposed in vivo to SSCS (an indicator of DNA/genetic damage). Finally, in an experimental in vivo lung cancer model, SP therapy significantly reduced the numbers of lung tumors, increased animal survival, and activated pulmonary immune defense mechanisms. Thus, aerosolized SP therapy appears to be capable of inhibiting, preventing and/or reversing the cellular and genetic precursors of emphysema and malignancy that often result from exposure to cigarette smoke.
Taste Preferences and Taste Sensitivity: Associations with Food Preferences, Dietary Intake and Body Composition

Taste sensitivity, or the ability to detect the degree of bitterness, sweetness or saltiness, has been associated in previous studies with preferences for a limited number of single- item foods. Ho...
Lateral vegetation growth rates exert control on coastal foredune hummockiness and coalescing time

Abstract. Coastal foredunes form along sandy, low-sloped coastlines and range in shape from continuous dune ridges to hummocky features, which are characterized by alongshore-variable dune crest elevations. Initially scattered dune-building plants and species that grow slowly in the lateral direction have been implicated as a cause of foredune hummockiness . Our goal in this work is to explore how the initial configuration of vegetation and vegetation growth characteristics control the development of hummocky coastal dunes including the maximum hummockiness of a given dune field. We find that given sufficient time and absent external forcing, hummocky foredunes coalesce to form continuous dune ridges. Model results yield a predictive rule for the timescale of coalescing and the height of the coalesced dune that depends on initial plant dispersal and two parameters that control the lateral and vertical growth of vegetation, respectively. Our findings agree with previous observational and conceptual work – whether or not hummockiness will be maintained depends on the timescale of coalescing relative to the recurrence interval of high-water events that reset dune building in low areas between hummocks. Additionally, our model reproduces the observed tendency for foredunes to be hummocky along the southeast coast of the US where lateral vegetation growth rates are slower and thus coalescing times are likely longer.
Thyrotropin Releasing Hormone: A Powerful Tripeptide with Diverse Effects in Horses

Abstract Thyrotropin-releasing hormone (TRH) was the first trophic “factor” from the hypothalamus to be isolated and identified chemically. It was known to have a stimulatory effect on thyroid-stimulating hormone (TSH) production and secretion by cells within the adenohypothesis, and its structure was revealed to be a modified tripeptide: (pyro)Glu-His-Pro-NH2. Intravenous or intramuscular injection of TRH to horses results in an immediate rise in plasma TSH concentrations, as would be expected. However, it is now known that TRH has consistent effects on four of the other five cell types in the equine adenohypophysis as well. Administration of TRH to horses stimulates not only plasma TSH concentrations, but also plasma prolactin, adrenocorticotropic hormone, and melanocyte-stimulating hormone concentrations. In contrast, administration of TRH simultaneously or within 1 hour before administration of secretagogues for growth hormone (GH) greatly reduces the GH response to the secretagogues. To date, TRH has not been reported to have positive or inhibitory effects on the release of luteinizing hormone or follicle-stimulating hormone from gonadotropes. Whether the noted effects of TRH on cells other than the thyrotropes are physiologic or pharmacologic is not clear. Regardless, a significant clinical utility has developed for the use of TRH in diagnosing thyroid gland disease as well as pituitary pars intermedia dysfunction in horses.
Clepsydra: modeling timing flows in hardware designs

Emergence of side channel security attacks has challenged the classic assumptions regarding what data is publicly available. As demonstrated repeatedly, statistical analysis of information collected by measuring completion time of hardware designs can reveal confidential information. Even though timing-based side channel leakage can be easily exploited to breach data privacy, conventional hardware verification tools are not yet suited to assess these vulnerabilities. To acquaint the hardware design process with formal security evaluations, we introduce a model for tracking timing-based information flows through HDL codes. Based on this model, we have developed Clepsydra, a tool for automatically generating circuitry for tracking timing flows and generic logical flows within hardware designs in two distinct channels. The circuit generated by Clepsydra can be analyzed by EDA tools to detect timing leakage or formally prove constant execution time. We present proofs regarding soundness and precision of the proposed model along with results of employing Clepsydra to verify security properties on a variety of hardware units including crypto cores, bus architectures, caches and arithmetic modules.
Linear load model for robust power system analysis

Extension of constant power (PQ) load models to more accurately represent the electric load behavior in the grid has produced models (e.g. ZIP) that have been shown to improve the accuracy of load characterization, but like PQ load models, they introduce nonlinearities in the power flow formulation that make it more susceptible to divergence or convergence to a non-physical solution. In this paper a first-order load model (BIG) based on equivalent circuit principles is proposed that offers accuracy comparable to a ZIP model, but unlike ZIP, is linear and captures angle information when used in a current-voltage based power flow formulation. Advanced machine learning techniques are applied to fit parameters for the BIG model and traditional models using time series measurement data from our university campus and from μΡΜυ installed at Lawrence Berkeley National Laboratory. The results show that the linear BIG model characterizes the load behavior far better than PQ load models while having a similar fit to that of more complex non-linear ZIP load model while offering complexity and modeling benefits.
Efficacy of peritoneal dialysis in neonates presenting with hyperammonaemia due to urea cycle defects and organic acidaemia.

AIM Newborns with inborn errors of metabolism can present with hyperammonaemic coma. In this study, we evaluated the effect of peritoneal dialysis on plasma ammonium levels and on the short-term outcome in neonatal patients with urea cycle defects and organic acidaemia. METHODS Data from infants with hyperammonaemia due to urea cycle defects or organic acidaemia treated with dialysis were collected and retrospectively analyzed. The results of patient groups (group I, survived; and group II, died) were compared. RESULTS Fourteen neonates were enrolled in this study. In group I, plasma ammonium levels before dialysis were median (IQR) 1652 μg/dL (1165-2098 μg/dL); in group II, they were 1289 μg/dL (1070-5550 μg/dL). There was no statistically significant difference. Urea cycle defects were diagnosed in eight, and organic acidaemia in six patients. The duration of a blood ammonia level >200 μg/dL was longer in group II (P = 0.04). A <60.8% decline in the ammonia level from the beginning of dialysis to the 12th hour of dialysis carried a 3.33-fold higher risk of mortality, when compared with a greater decline. Five patients with urea cycle defects, and one with organic acidaemia, died. The mortality risk was 8.33-fold (95% CI = 0.63-90.86) higher for patients with urea cycle defects than for those with organic acidaemia. CONCLUSION In patients with hyperammonaemia treated with peritoneal dialysis, the rate of ammonia removal and the underlying aetiology appear to be important prognostic factors. Neonates with organic acidaemia who are admitted to centres without continuous renal replacement therapy facilities can be effectively treated with peritoneal dialysis.
What's in Common between Test, Model Checking, and Decision Procedures?

The interaction of proof search and counterexample search is at the heart of recent methods in decision procedures model checking. In this talk, we'll consider the relation between these methods and test.
Optimizing Storage Operation for a Probabilistic Locational Marginal Pricing Forecast

This paper explores the applicability of using dynamic programing (DP) and approximate dynamic programming (ADP) based methods for optimal dispatch of utility scale energy storage systems (ESS). In this study, the effectiveness of these approaches have been tested using the IEEE 13 node test feeder with distributed photovoltaics (PVs) and a utility scale storage system. In this work, a co-simulation based approach has been used to setup the experiment to be able to implement detailed ESS and network models. The results obtained from DP/ADP runs have been compared with three other control strategies both myopic and intelligent. Simulations results show that DP/ADP algorithms are a good candidate for optimal EES dispatch in terms of both solution quality and execution time.
Interdisciplinary scholarly collaboration in data-intensive, public-funded, international digital humanities project work

Abstract The information practices of collaborative interdisciplinary researchers, especially in distributed environments, remain understudied. Embracing the naturalistic paradigm, this qualitative case study relies upon semi-structured interviews, snowball sampling, and grounded analysis. Based on interviews with 53 participants from 11 Digging Into Data 3 (DID3, 2014-2016) projects, this study examines the working practices of scholars (library and information science professionals, humanists, and computer scientists) engaging in collaborative, international, data-intensive, publicly-funded interdisciplinary research. Benefits of such work include avoiding redundancy, exploding disciplinary silos, and more ambitious, larger-scale outputs. Challenges and lessons learned center on innovation, flexibility, and failure, translation, intermediaries, divisions of labor and delegation of responsibilities and tasks, conflict resolution, technology, outputs and publication, and timeframe, sustainability, and infrastructure.
Effects of Nonpharmacological Interventions for Fatigue in Patients with Heart Failure: A Systematic Review and Meta-Analysis

Background Fatigue is the primary symptom accompanied with dyspnea in heart failure (HF). The symptoms limit activities of daily living, lower quality of life, drive the need for HF-related hospitalizations, and signal a poor prognosis in the HF condition. Although fatigue has been noted as a common symptom in HF, there has been limited research measuring the quantitative and qualitative aspects of fatigue in HF. Moreover, relatively few studies have been designed to manage fatigue in HF patients compared to those of cancer-related fatigue. Objective This study aims to analyze the trend of research on management of fatigue for patients with HF and to determine the effects of nonpharmacological interventions through a systematic review and meta-analysis. Methods The databases of MEDLINE, EMBASE, the Cochrane library were systematically explored for eligible studies, using the combinations of MeSH terms, free-text terms, and Boolean operators. The authors independently evaluated the eligibility of the studies published before March 1st, 2018, and extracted the data. The quality assessment was then conducted individually using the Cochrane Collaboration's Risk of Bias Tool. Each of the study results was compared and synthesized using the effect sizes, such as standardized mean difference (SMD), weighted mean difference (WMD) with a 95% confidence intervals (CIs). Heterogeneity was confirmed through the I2 statistic. Results Eight studies were included-7 were randomized controlled trials; the other was a quasi-experimental study. The types of the interventions involved exercise, education, muscle relaxation, meditation, and biofeedback. The primary outcome was the level of the fatigue measured from the HF patients in the studies. Meta package in R version 3.4.3 was employed to conduct the meta-analysis for the overall 514 participants across the studies. Figure 1 illustrates the forest plot for the results. Random-effects model reveals that nonpharmacological interventions had a significant effect on fatigue in HF patients (SMD = -0.77; 95% CI -1.04 to -0.50). The heterogeneity of the effect sizes was moderately high (I2 = 57%, χ2 =0.10, p =0.01). Conclusion Findings suggest that a nonpharmacological intervention decreases the fatigue in HF population. This calls for more methodological and intervention-driven research devoted to advancing fatigue management programs for the better quality of life of patients with HF.
The prognostic and predictive impact of inflammatory biomarkers in patients who have advanced‐stage cancer treated with immunotherapy

BACKGROUND Optimal prognostic and predictive biomarkers for patients with advanced-stage cancer patients who received immunotherapy (IO) are lacking. Inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), and the platelet-to-lymphocyte ratio (PLR), are readily available. The authors investigated the association between these markers and clinical outcomes of patients with advanced-stage cancer who received IO. METHODS A retrospective review was conducted of 90 patients with advanced cancer who received treatment on phase 1 clinical trials of IO-based treatment regimens. NLR, MLR, and PLR values were log-transformed and treated as continuous variables for each patient. Overall survival (OS), progression-free survival (PFS), and clinical benefit were used to measure clinical outcomes. For univariate associations and multivariable analyses, Cox proportional-hazards models or logistic regression models were used. RESULTS The median patient age was 63 years, and most were men (59%). The most common histologies were melanoma (33%) and gastrointestinal cancers (22%). High baseline NLR, MLR, and PLR values were associated significantly with worse OS and PFS (P < .05) and a lower chance of benefit (NLR and PLR; P < .05). Increased NLR, MLR, and PLR values 6 weeks after baseline were associated with shorter OS and PFS (P ≤ .052). CONCLUSIONS Baseline and early changes in NLR, MLR, and PLR values were strongly associated with clinical outcomes in patients who received IO-based treatment regimens on phase 1 trials. Confirmation in a homogenous patient population treated on late-stage trials or outside of trial settings is warranted. These values may warrant consideration for inclusion when risk stratifying patients enrolled onto phase 1 clinical trials of IO agents.
Factor structure of the Behavioral Assessment Screening Tool (BAST) in traumatic brain injury.

Objective: Establish the factor structure of the Behavioral Assessment Screening Tool (BAST), a self-reported emotional/behavioral symptom measure for adults with traumatic brain injury (TBI).Setti...
Laser induced graphene /ceramic membrane composite: Preparation and characterization

Abstract In this work, laser induced graphene (LIG) was successfully fabricated on microporous ceramic membranes. The surface area, morphology, and chemical characterizations were performed on the LIG layer. Water contact angle measurements showed the hydrophobicity of LIG. Pure water and solvents with different polarities were used to understand the solvent flux behavior of LIG membrane. The LIG membrane showed very high non-polar solvent fluxes and remarkably low water permeability, and thus, the transport through the LIG membrane is related to dipole moment and dielectric constant, represented by solvent polarity. The LIG membrane achieved 90% rejection for 255 nm diameter silica particles, suggesting the presence of submicron size connecting pore channels that dominate the transport mechanism.
New Opportunities with Old Optical Materials

Nanostructured diamond and lithium niobate devices will be presented, with applications in quantum communications, data- and tele-com, sensing (e.g. using frequency combs), and so on.
Measuring beach accessibility for people with ambulatory difficulty.

People with disabilities especially those with ambulatory difficulty (PWAD) have particularly limited access to recreation settings such as parks and other open spaces and this trend is expected to continue in the future. Given the limited access and physical limitations of PWAD, they cannot experience the multiple benefits of recreational activities. Beaches are an essential recreation setting that could provide significant physiological, psychological, and social benefits to PWAD. Providing adequate beach access for PWAD has been regarded as an important responsibility of public leisure agencies since the passage of the Americans with Disabilities Act (ADA) of 1990. Several studies have measured PWAD’s levels of access to fitness centers, community sports/recreation centers, and swimming pools, but there is a lack of empirical research with respect to beaches. The purpose of this study was therefore to measure beach accessibility for PWAD based on Duval County, Florida. To consider PWAD’s unique physical characteristics, the beach access points were selected based on the ADA guidelines and a specific distance (0.25 miles) criteria. In addition, two distance-based access measures (1. the shortest street distance from the center of each census tract to the closest beach access point and 2. the average street distance from the center of each census tract to the seven closest beach access points) based on minimum distance and travel cost approaches were employed to demonstrate the sensitivity of the findings. GIS-based network analysis was employed to calculate the street distance. The results indicated that regional disparities in the levels of beach access for PWAD in Duval County were identified. Specifically, PWAD that live in the western, northern and southern regions of Duval County (e.g., cities of Baldwin and Jacksonville [northern and western part]) have extremely poor beach access. Conversely, PWAD that reside in the eastern region of the county (e.g., cities of Jacksonville [eastern part], Atlantic Beach, Jacksonville Beach, and Neptune Beach) have better beach access. This allows researchers and practitioners to better understand the local patterns of beach accessibility for PWAD, ultimately providing guidelines for location-based beach access planning and management. Such information could also be used by public leisure agencies to allocate limited resources, by identifying regions that are in need of increased recreational resources. Subscribe to JPRA
Using the Tampa Scale for Kinesiophobia Short Form in Patients With Upper Extremity Specific Limitations.

Background: The Tampa Scale for Kinesiophobia (TSK) is used to quantify fear of painful movement. A shorter form with only 4 questions (TSK-4) can be used by physicians to look for fear of movement...
Orbital Stabilization of Underactuated Systems using Virtual Holonomic Constraints and Impulse Controlled Poincaré Maps

Abstract The problem of orbital stabilization of underactuated mechanical systems with one passive degree-of-freedom (DOF) is revisited. Virtual holonomic constraints are enforced using a continuous controller; this results in a dense set of closed orbits on a constraint manifold. A desired orbit is selected on the manifold and a Poincare section is constructed at a fixed point on the orbit. The corresponding Poincare map is linearized about the fixed point; this results in a discrete linear time-invariant system. To stabilize the desired orbit, impulsive inputs are applied when the system trajectory crosses the Poincare section; these inputs can be designed using standard techniques such as LQR. The Impulse Controlled Poincare Map (ICPM) based control design has lower complexity and computational cost than control designs proposed earlier. The generality of the ICPM approach is demonstrated using the 2-DOF cart–pendulum and the 3-DOF tiptoebot.
Color, structure, and rheology of a diblock bottlebrush copolymer solution

A structure–property–process relation is established for a diblock bottlebrush copolymer solution, through a combination of rheo-neutron scattering, imaging, and rheological measurements. Polylactic acid-b-polystyrene diblock bottlebrush copolymers were dispersed in toluene with a concentration of 175 mg ml−1, where they self-assembled into a lamellar phase. All measurements were carried out at 5 °C. The solution color, as observed in reflection, is shown to be a function of the shear rate. Under equilibrium and near-equilibrium conditions, the solution has a green color. At low shear rates the solution remains green, while at intermediate rates the solution is cyan. At the highest rates applied the solution is indigo. The lamellar spacing is shown to be a decreasing function of shear rate, partially accounting for the color change. The lamellae are oriented ‘face-on’ with the wall under quiescence and low shear rates, while a switch to ‘edge-on’ is observed at the highest shear rates, where the reflected color disappears. The intramolecular distance between bottlebrush polymers does not change with shear rate, although at high shear rates, the bottlebrush polymers are preferentially aligned in the vorticity direction within the lamellae. We therefore form a consistent relation between structure and function, spanning a wide range of length scales and shear rates.
A Cadaveric Study of the Plantar Fascia for the In-Step Plantar Fasciotomy

The in-step plantar fasciotomy has remained a viable option for treatment of plantar fasciitis. The level of the in-step procedure has previously been described as 1.5 cm distal to the anterior heel fat pad. The authors are unaware of any study defining mean width and thickness of the plantar fascia at specific distances from its insertion. The authors performed a standardized cadaveric dissection of 25 fresh frozen cadaveric specimens from a local region in Pennsylvania. Each fascial band width and thickness of the plantar fascia was measured at the fascial insertion, 2 cm distal from insertion, and 3 cm distal from insertion. The mean (± standard deviation) width of the medial, central, and lateral band of the plantar fascia 3 cm from its insertion was 25.3 ± 5.3, 25 ± 3.41, and 23.3 ± 4.49 mm, respectively. At the same anatomic distance, the band thicknesses were 1.5 ± 0.82, 3.3 ± 0.85, and 1.9 ± 0.33 mm, respectively. The literature describes 2 techniques. The first is transecting between one-third to two-thirds of the plantar fascia during a fasciotomy from medial to lateral. The second is identifying, isolating, and releasing the central band. Our study allows to further quantify this, equating to 24.5 to 49 mm in total medial to lateral transection at 3 cm distal from insertion and an isolated central band equating to 25 ± 3.41 mm. With quantitative measurements of transection length, the surgeon will avoid having to estimate and potentially overtransect. This may help in preventing postoperative sequela related to overcorrection.
Value management in the evaluation of the ecological projects and their realization

The aim of the article is to describe and to evaluate the exploitation of the outsourcing in the range of the ecological projects of Jihoceska energetika, Joint Stock Company. The method of value management was used to assess the efficiency of suggested solutions, aimed at reaching the increase of competitive ability of the firms. It is specific type of management of innovations.
Strategies to enhance communication with telemental health measurement-based care (tMBC)

Telehealth has always held great promise to increase access to mental health care, never more so than in the age of COVID-19, when clients cannot or will not come to the clinician's physical location A feasible and effective alternative to traditional in-person care, telemental health requires that clinicians adopt new strategies to build and maintain communication and the therapeutic relationship This can be particularly troublesome for clinicians new to the modality, who may feel the loss of the "in-session" experience more acutely As an evidence-based practice that is transtheoretical and transdiagnostic, telemental health measurement-based care (tMBC) is the ideal complement to enhance systematic ongoing monitoring, treatment engagement, and therapeutic alliance in the context of the virtual encounter While tMBC mechanisms of actions are still being explored, there is promising evidence that tMBC improves clinician responsivity to acute client concerns By using client-reported measures, tMBC provides an important pathway for clients to systematically communicate with their clinicians, which can guide therapeutic actions and contribute to shared understanding This brief report summarizes the evidence for tMBC as a patient-centered communication tool and provides recommendations for evidence-based and practice-informed strategies to integrate tMBC into telehealth solutions, with suggestions for monitoring new concerns related to the COVID-19 crisis (PsycInfo Database Record (c) 2020 APA, all rights reserved) Impact Statement Clinical Impact Statement-This brief report suggests practical strategies to integrate measurement-based care into telemental health services With a focus on feasibility, recommendations address clinical workflow and considerations for measures selection COVID-19 specific information related to reimbursement and measures is provided (PsycInfo Database Record (c) 2020 APA, all rights reserved)
Revisiting Antiarrhythmic Drug Therapy for Atrial Fibrillation: Reviewing Lessons Learned and Redefining Therapeutic Paradigms

Since the clinical use of digitalis as the first pharmacological therapy for atrial fibrillation (AF) 235 years ago in 1785, antiarrhythmic drug therapy has advanced considerably and become a cornerstone of AF clinical management. Yet, a preventive or curative panacea for sustained AF does not exist despite the rise of AF global prevalence to epidemiological proportions. While multiple elevated risk factors for AF have been established, the natural history and etiology of AF remain incompletely understood. In the present article, the first section selectively highlights some disappointing shortcomings and current efforts in antiarrhythmic drug therapy to uncover reasons why AF is such a clinical challenge. The second section discusses some modern takes on the natural history of AF as a relentless, progressive fibro-inflammatory "atriomyopathy." The final section emphasizes the need to redefine therapeutic strategies on par with new insights of AF pathophysiology.
The sense of an ending : studies in the theory of fiction : with a new epilogue

1. The End 2. Fictions 3. World without end or beginning 4. The modern apocalypse 5. Literary fiction and reality 6. Solitary confinement Epilogue: The Sense of an Ending, 1999 Notes
AI compensation of crosstalk in WDM communication

Wavelength Division Multiplexing (WDM) is the key technology in ultra-high capacity links that form the backbone of the internet. Hundreds or more data channels each at a different wavelength travel through a single fiber resulting in aggregate data rates exceeding many Terabits per second. The fundamental limit to the data transmission rate is the optical crosstalk between channels induced by the inevitable nonlinearity of the fiber. Traditional methods for compensating for the reduction in the bit error rate caused by the crosstalk include numerical backpropagation as well as nonlinear Volterra filter, both implemented in the digital domain at the receiver. Backpropagation through the canonical nonlinear Schrodinger equation is computationally expensive and beyond the capability of today’s DSP at the data rates that optical networks operate. Volterra filters scale superlinearly with an increasing number of taps and which in turn scale with the amount dispersion in the fiber. Therefore, they are not the ideal solution for high data rates. In this talk, we report on the application of machine learning, and neural networks in particular, on the compensation of optical crosstalk in WDM communication. We compare the performance of different machine learning models such as support vector machine (SVM), decision tree, convolutional neural network (CNN) in terms of the achievable bit error rate on both binary and multilevel modulated data. We further evaluate the sensitivity of the error rate to the resolution of the analog to digital converter (ADC) and to the signal to noise ratio as well as the latency of our algorithms
Opioid Prescribing Habits for Common Arthroscopic Procedures in Opioid Naïve Patients.

Background:With the opioid epidemic and the increasing number of opioid-related deaths, there is growing awareness in the medical community regarding the dangers of opioid overprescription. As a re...
Abstract W P75: New Generation Hydrogel Endovascular Aneurysm Treatment Trial

Background: Endovascular treatment of intracranial aneurysms has seen significant advances. One major limitation of the endovascular approach is durability of treatment and aneurysm recanalization. To address this issue, one approach was the development of hydrogel-coated coils. Hydrogel expands upon exposure to blood and thus enhances coil packing density. Higher initial coil packing density may potentially result in lower rates of recurrence. Hypothesis: The 2nd Generation HydroCoil Embolic System allows for a higher packing density, higher initial occlusion, lower recanalization, and lower retreatment rates compared to bare platinum coils. Objective: To compare clinical and angiographic outcomes (initial complete occlusion, recanalization, retreatment, and adverse event rates) in patients receiving the 2nd Generation HydroCoil Embolic System versus patients receiving bare platinum coils. Methods: This is a randomized, controlled, multicenter, post-market clinical trial. Subjects between 18 and 75 years of age with ruptured or unruptured intracranial aneurysms (3-14 mm in size) who are amenable to endovascular treatment are randomly assigned 1:1 to one of two treatment arms: 1) the HydroCoil Embolic System (HES), or 2) bare platinum coils. No bioactive coils, 1st generation HydroCoils or liquid embolics are allowed in the study. In the HES arm, up to 10% of total coil length using bare platinum is allowed if deemed necessary by the investigator. Any type of bare platinum coil may be utilized in the bare platinum arm. Assist-devices can be used at the discretion of the investigator. The duration of the open enrollment phase will be 24 months or until the required number of subjects are enrolled (n = 600). Each subject will have a post-procedure follow-up of at least 18 months. Subjects will be recruited from up to 50 national and international centers. Each Investigational Site will be expected to enroll at least 20 Subjects. Results: A total of 368 patients have been enrolled to date in the study. The study is still ongoing. Conclusions: A limitation of endovascular aneurysm treatment is recurrence. This trial aims to answer the question of whether the new generation hydrogel coil reduces recurrence rates when compared to bare platinum coils.
Introduction: Epidemiology, Risk Factors, Pathology, and Natural History of Head and Neck Neoplasms

This introductory chapter sets the scene for the book by defining the complex domain in which the head and neck radiologist is expected to make his diagnosis. The epidemiology of epithelial and non-epithelial head and neck tumors is discussed representing up-to-date frequency measures. The known risk factors are subsequently reported. After that the clinical and pathological specifics of the most frequent tumors are presented, along with the expected natural history, so that the head and neck radiologist is aware of the different stages of the disease and the radiological “snapshots” that can result from imaging at different points in the evolution of the disease. Both macroscopic and microscopic aspects are illustrated by to-the-point clinical and light-microscopical pictures.
Transformation of China’s Landscape: Assessing the Multiple Scales of Change in Shanghai, Beijing, and along the Middle Reaches of the Yangtze River

China has undergone a profound metamorphosis that is unmatched in its long history. Its sustained fast economic growth, burgeoning market economy, expanding private sector, rural industrialization, unprecedented interregional migration, and increasing links between the Chinese economy and the world economy are all reshaping the landscape of this fascinating and complex giant. Max Lu (2004), p. 1.
Elucidation of XA21-mediated innate immunity

In the early 1970s, the Xa21 gene from the wild rice species Oryza longistaminata drew attention of rice breeders because of its broad-spectrum resistance to diverse strains of a serious bacterial disease of rice in Asia and Africa, called 'bacterial blight disease', caused by the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae (Xoo). In 1995, we isolated the gene controlling this resistance and in 2009 demonstrated that XA21 recognizes a highly conserved peptide, called 'Ax21' (activator of XA21-mediated immunity). Tyrosine sulfation of Ax21 is required for recognition by rice XA21. A decade of genetic, molecular and biochemical studies have uncovered key components of the XA21-mediated signalling cascade. Ax21 recognition by XA21 at the cell surface induces phosphorylation-mediated events, which are predicted to alter subcellular localization and/or DNA-binding activity of a WRKY family of transcription factors. Because XA21 is representative of the large number of predicted pattern recognition receptors (PRRs) in rice (n = 328), Arabidopsis (n = 35) and other plant species, further characterization of XA21-mediated signalling pathways will contribute to elucidation of these important defence responses.
The kinetics of intravenously injected radioactive vitamin B12: studies on normal subjects and patients with chronic myelocytic leukemia and pernicious anemia.

1. Studies of the fate of intravenously injected radioactive vitamin B12 have been performed in patients with normal, low and high serum concentrations of vitamin B12. 2. Abnormal plasma disappearance curves were noted in chronic myelocytic leukemia, pernicious anemia in relapse and in remission, total gastrectomy and malabsorption syndrome. 3. In chronic myelocytic leukemia, the slow clearance of plasma radioactivity may be explained by the increased binding capacity of the plasma proteins for vitamin B12. 4. Plasma clearance of radioactivity is slower than normal in pernicious anemia, even in remission. The failure of the disappearance curve to return to normal in pernicious anemia in complete remission suggests the existence of a plasma "B12-transferase," whose function is to transfer circulating B12 to the tissues. The disappearance curves suggest that the amount of such "B12-transferase" is diminished in pernicious anemia, total gastrectomy and certain Cases of malabsorption syndrome. 5. A relationship between a hypothetical "B12-transferase" and intrinsic factor is discussed.
Marketing Internships: Expectations and Perceptions of Students and Internship Providers

Internships are three-way partnerships between the educational institution, the student intern, and the company where the intern takes on the challenges of a program of systematic experiential learning. An intern is someone who is involved in a part-time or full-time work experience that is related to the student’s career goal or major, who may be paid or unpaid, may or may not be receiving academic credit for the internship, but who is a temporary employee (Tovey 2001). The lack of relevant work experience and/or internships is a key complaint of employers, and a determining factor in employment decisions with one-third of firms in a recent study indicating that job candidates with an internship experience are strongly preferred over those lacking this credential (NACE 2007). Accordingly, as marketing educators continue to move to more experiential learning pedagogies, the internship has become more widely employed (Karns 2005). As such, it is important that the realities of the employment market are aligned strategically with marketing internship programs. Specifically, input from business organizations “can help ensure that the expectations of our off-campus partners are being met in ways that are both consistent with our academic missions and meaningful to future employers” (Sapp and Zhang 2009, p. 277).
Rhamnolipid-enhanced mineralization of phenanthrene in organic-metal Co-contaminated soils

Successful remediation of soils co-contaminated with organics and metals may require a combination of technologies. This research addresses the organic component within co-contaminated sites. It is...
Browsing the culture: membership and intertextuality at a Mormon bookstore

This paper argues that organizational and local host cultures are related through the intertextual performance of membership. It proceeds by claiming that organizations may be usefully read as intertexts, and that the relationship between organizations and their environments is enacted by speakers as they negotiate their multiple identities in talk. These claims are then used to analyze the intertextual performance of membership at a Salt Lake City, Utah bookstore owned by the Mormon church. The analysis demonstrates how: (1) organizational routines surrounding the interpretation of product serve as performances of host-cultural membership; (2) communication among and between store employees and customers clarifies types of host-cultural identity; and (3) the management of controversial texts enacts the organizational environment. The analysis is intended to mark an intersection between organizational and cultural studies by demonstrating how organizations potentially function as sites for the reproductio...
SIGNIFICANCE OF CELL DIVISIONS IN DIFFERENTIATING SECONDARY PHLOEM

Among 91 species in 77 genera of 44 families of dicotyledons surveyed in the present study 35 species showed evidence that various anticlinal divisions occur in the secondary phloem mother cells that produce sieve elements. These divisions range in orientation from transverse through oblique to vertical. The derivatives of these divisions consist of two or more sieve elements with their companion cells or of combinations of sieve elements, companion cells, and parenchyma cells. Frequently the divisions result in sieve elements shorter than their mother cells. The occurrence of these anticlinal divisions has a bearing upon the problem of phylogenetic and physiologic specialization of sieve elements.
Some Effects of Gravel Mixtures on Emergence of Coho Salmon and Steelhead Trout Fry

Abstract Eight mixtures of sand and gravel were tested in experimental troughs, to simulate hatching conditions in coho salmon (Oncorhynchus kisutch) and steelhead trout (Salmo gairdneri) redds. Fry were released into perforated, open-ended chambers below the gravel surface. An inverse relationship was found between the quantity of fines and emergent survival. Mean emergent survival for coho salmon ranged from 96% in the control mixture to 8% in 70% sand (less than 3.3 mm diameter). Mean emergent survival for steelhead ranged from 94% to 18%, respectively. Premature emergence of coho fry was related to higher concentrations of fines. These premature fry were smaller, and retained more yolk than fry emerging at normal times.
A microbiologic evaluation of endodontic instrumentation in pulpless teeth.

Abstract Thirty-three patients with infected root canals were selected for endodontic therapy, and the canals were enlarged under aseptic conditions without the use of an irrigant. Of the cultures of dentin substance removed, 21.4 per cent were negative, and few viable bacteria were detectable during the later stages of canal enlargements. More culturable bacteria were obtained on absorbent points than from dentin removed on reamers. Sodium hypochlorite was found to be an effective germicidal irrigant after canal enlargement, producing “sterile” canals in nearly 75 per cent of the teeth. However, 53.3 per cent of the supposedly “sterile” canals produced positive cultures at the next appointment. More than one fourth of the 504 cultures in this study were negative after 48 hours but became positive after 5 days.
Melanin and nicotine: A review of the literature.

The role of melanin in nicotine uptake and metabolism has received little attention. Because nicotine has been shown to accumulate in tissues containing melanin, exploring links between melanin and nicotine may provide additional clues to understanding smoking behavior and disease effects. To examine the scientific literature on the relationship between melanin and nicotine, we conducted a PubMed search. We also searched online archives of internal tobacco industry documents. We retrieved and reviewed 82 published research papers related to melanin and nicotine or melanin and metabolism of other drugs, and 150 relevant internal tobacco industry documents. The published literature suggests that nicotine may accumulate in human tissues containing melanin and this retention may increase melanin synthesis. Existing research on the relationship between melanin and nicotine lacks an adequate consideration of this relationship’s potential impact, if any, on nicotine metabolism, level of nicotine dependence, and ability to quit smoking. Differential accumulation of nicotine in melanin-containing tissues could have implications for individuals with high levels of melanin.