cssi/SciSciGPT-SciSciNet huggingface dataset:
Analysis of CFTR Folding and Degradation in Transiently Transfected Cells

Misfolding and premature degradation of F508del-CFTR is the major cause of cystic fibrosis. Components of the ubiquitin-proteasome system function on the surface of the endoplasmic reticulum to select misfolded proteins for degradation. The folding status of F508del-CFTR is monitored by at least two ER quality control checkpoints. The ER-associated Derlin-1/RMA1 E3 complex appears to recognize folding defects in CFTR that involve misassembly of NBD1 into a complex with the R-domain. In contrast, the cytosolic Hsp70/CHIP E3 complex appears to sense folding defects that occur after synthesis of NBD2. Herein we describe methods that allow for the study of how modulation of these ER quality control factors by siRNA impacts CFTR folding and degradation. The experimental system described employs transiently transfected HEK293 cells and is utilized to monitor the biogenesis of CFTR by both Western blot and pulse chase studies. Methods to detect complexes formed between CFTR folding intermediates and ER quality control factors will also be described.
Roots, Motives, and Patterns in Children’s Prosocial Behavior

Prosocial behavior is a matter of ancient as well as modern interest. The long history of philosophy and social thought about the “goodness” of human nature makes us aware that current empirical research and the theories upon which it is based are not fashioned de novo but have their origins in these predecessors. Human nature has been variously regarded. It has been viewed as innately endowed with feelings of compassion in Confucian philosophy (Chan, 1963), as naturally virtuous and with a communal sense of seif (Rousseau, 1755/1952), as waging a war of all against all and as based on rational self-interest (Hobbes, 1651/1952). Accordingly, children have been variously regarded and reared, and, perhaps, as a result, they have been variously prosocial.
Smartphone Apps: A Patient's New Best Friend?

The end of the 20th century saw the introduction of the internet. Approximately two decades later, the internet has been strongly adopted by every segment of public society. In 2013, 74.4% of all United States households reported internet use, with 73.4% reporting a dedicated high–speed internet
Racial Variations in Mean Serum Vitamin A (Retinoic Acid) Levels in Multiple Sclerosis Patients with Normal/Corrected Vitamin D Levels (P3.012)

Objective: To Determine If There are Ethnic/Racial Variations in Vitamin A levels in Multiple Sclerosis(MS) patients with Normal Vitamin D levels Background: Vitamin A or retinoic acid is a lipid soluble vitamin like vitamin D.Although recent literature indicates an association of serum vitamin A levels with MS lesion load, disease severity and/or progression, it is unclear what role it plays independent of vitamin D. Some vitamin A receptors and vitamin D receptors are known to dimerize. But it is unknown whether serum vitamin D levels influence serum vitamin A levels. It is also unknown if there are racial variations in vitamin A levels in MS patients with normal vitamin D levels Methods: A retrospective analysis of data collected from our MS clinic patients was undertaken.Relapsing remitting MS patients with normal or corrected vitamin D levels were included in the study and serum vitamin A, retinol binding protein and carotene levels were collected in those patients with serum vitamin D levels that were normal (>30).MRI data was collected from scans done within about three months of the blood draws. Results: The average serum vitamin A levels for the caucasian, african american, and hispanic MS patients was 74.67, 53.38, and 55.36 respectively.Although no racial group had a mean level that was low, there were statistically significant differences in the mean vitamin A levels between the caucasian group and the african american groups (p=0.013) but not between the african american and hispanic groups.Review of differences in EDSS and MRI data (including lesion number) between these groups is discussed. Conclusions: There appears to be racial variations in vitamin A levels in MS patients with normal vitamin D levels. Additional research is needed to determine if vitamin A, independent of vitamin D,can influence the natural history of disease in MS patients. Disclosure: Dr. Mehta has received personal compensation for activities with Biogen, TEVA CNS, and Gerson Lehrman Group as a speaker and/or consultant. Dr. Berube has nothing to disclose.
Femoral Nerve Block after Anterior Cruciate Ligament Reconstruction

Femoral nerve block (FNB) has been proposed for pain control following anterior cruciate ligament (ACL) reconstruction. Although numerous studies have assessed the efficacy of FNBs, there has been little to no research into the effect of such blocks on postoperative strength and patient-reported outcomes. We hypothesized that performance of an FNB would result in decreased quadriceps strength and poorer patient-reported outcome scores within the first 6 months following ACL reconstruction. A total of 30 patients scheduled to undergo hamstring autograft ACL reconstruction following an acute ACL injury were randomized to a single-shot FNB group or a control group. Preoperatively, patients completed a Knee Injury and Osteoarthritis Outcome Score (KOOS) and isokinetic quadriceps strength testing at 60 degrees/second. At 6 weeks postoperative, 29 of 30 patients completed a KOOS and isometric quadriceps strength testing at 90 degrees. At 6 months postoperative, 23 of 30 patients completed a KOOS and isokinetic strength testing. Quadriceps femoris strength limb symmetry indices (QF-LSI) were calculated at all time points. Repeated measures analysis of variance (ANOVA) models were then utilized to model the effect of FNB and time on QF-LSI as well as KOOS subscales for activities of daily living, pain, and symptoms. QF-LSI and all KOOS subscales demonstrated improvement with time following ACL reconstruction. Repeated measures ANOVA demonstrated that patients who underwent FNB had a mean QF-LSI that was 13.4% lower than the control group (p = 0.005) and poorer KOOS symptoms subscale scores (10.4 point difference, p = 0.032) at 6 weeks postoperative compared with controls. At 6 months postoperative, no differences were noted in QF-LSI or any of the KOOS subscales based on block status. FNB resulted in decreased strength and poorer KOOS symptom subscale score at 6 weeks following ACL reconstruction compared with controls. These differences resolved by 6 months postoperative. The long-term effect of delayed quadriceps recovery on movement patterns and functional outcome remains unknown and requires further study. The study is a randomized controlled trial with level of evidence 1.
Correlation of Cellular Phospholipid Content with Nisin Resistance of Listeria monocytogenes Scott A.

A nisin-resistant mutant of Listeria monocytogenes Scott A has been characterized by comparing its phospholipid composition with the nisin-sensitive parental strain. The total phospholipids of resistant cells were significantly (P < 0.001) decreased compared to the parental strain. The types of phospholipids isolated from nisin-resistant and sensitive cells were identical, but there was a significant decrease (P < 0.01) in the amount of three individual phospholipids. Nisin-resistant cells were found to bind less nisin and release less phospholipids than sensitive cells when treated with same concentrations of nisin. The cell surface of resistant cells was less hydrophobic compared to sensitive cells, which also may have contributed to the observed nisin resistance. The results suggest that fundamental changes occurred in the membrane structure and function of the resistant mutant as a response to nisin.
Electron Excitation Cross Section of the 3 S 2 → 3 P 2 Transition of Sodium

The cross section of the $3^{2}S\ensuremath{\rightarrow}3^{2}P$ transition of sodium produced by electron impact has been calculated by performing a numerical integration of the set of three-channel differential equations. By means of this numerical procedure, it is no longer necessary to replace the nondiagonal matrix elements of the interaction potential by their asymptotic forms and to neglect the diagonal part of the interaction-potential matrix, as was done in the previous calculations. The cross sections calculated by this numerical scheme are smaller than those of the previous work, and the difference can be ascribed to the use of the true interaction potentials rather than their asymptotic forms. An outline of the general formulation of the numerical method for an $n$-channel case is given.
Commanding home robots: A comparison between older adults with and without mobility loss

Developing robots that are useful to older adults is more than simply creating robots that complete household tasks. Careful consideration of the users’ capabilities, robot autonomy, and task is needed. Perceived usefulness, according to the Technology Acceptance Model (TAM), is described as a person’s perception of how well the technology’s capability matches his or her own needs. The purpose of this qualitative study was to investigate the construct of perceived usefulness within the context of robot assistance and user capability. Two user groups participated: mobile older adults (N = 12; used no ambulation aid) and older adults with mobility loss (N=12; used walker or wheelchair). Participants took part in a think aloud task. We asked participants to discuss their robot control preferences for household tasks (e.g., clean, find and fetch). Older adults with mobility loss tended to prefer to command/control the robot themselves (low robot autonomy); however, mobile older adults’ preferences were split ...
Resuscitating to Save Life or Save Death

Imagine a world without CPR. A young boy floats upside down in a swimming pool during a birthday party. The host pulls the limp body out of the water. A young mother wakes up to feed her newborn bu...
Obesity-Associated Hypertension: the Upcoming Phenotype in African-American Women

The present obesity epidemic particularly affects African-American women. Whether the obesity epidemic will alter the hypertension phenotype in African-American women is entertained. The prevalence of morbid obesity is steadily increasing in African-American women, who are prone to developing hypertension (HTN) even in the absence of obesity. The obesity-associated hypertension phenotype is characterized by marked sympathetic nervous system activation and resistance/refractoriness to antihypertensive therapy. Weight loss achieved through lifestyle interventions and pharmacotherapy has a modest and rarely sustained antihypertensive effect. In contrast, bariatric surgery has a sustained antihypertensive effect, as evidenced by normalization of hypertension or lessening of antihypertensive therapy. The prevalence of HTN and its obesity-associated phenotype is likely to increase in African-American women over the next decades. Obese African-American women may be increasingly referred for bariatric surgery when hypertension remains uncontrolled despite lifestyle interventions and pharmacological therapy for weight loss and blood pressure (BP) control.
Pediatric heart disease simulation curriculum: Educating the pediatrician

Background Training guidelines state that pediatricians should be able to diagnose, manage, and triage patients with heart disease. Acutely ill cardiac patients present infrequently and with high acuity, yet residents receive less exposure to acute cardiac conditions than previous generations. Trainees must learn to manage these situations despite this gap. Simulation has been used successfully to train learners to provide acute care. We hypothesized that a simulation-based cardiac curriculum would improve residents' ability to manage cardiac patients. Methods Pediatric residents completed 4 simulation cases followed by debriefing and a computer presentation reviewing the learning objectives. Subjects returned at 1 month for postintervention cases and again at 4–6 months to measure knowledge retention. Cases were scored by 2 raters using a dichotomous checklist. We used repeated measure ANOVA and effect size to compare groups and intra-class correlation (ICC) to assess inter-rater reliability. Results Twenty-five participants were enrolled. Scores were low on pretesting but showed significant improvement (P < .05) in all 4 cases. No decay was noted on late testing. Pre-post effect sizes ranged from 1.1 to 2.1, demonstrating meaningful improvement. Inter-rater reliability (ICC) ranged from 0.61 to 0.93 across cases. Conclusions This novel simulation-based curriculum targets a gap in pediatric training and offers an effective way to train pediatricians. We plan to expand this curriculum to new populations of participants and have integrated it into our resident cardiology rotation.
Violence and Effects on Children

Understanding the effects of violence on children demands an interdisciplinary perspective, one that incorporates psychological, biological, sociological, anthropological, and historical insights within the context of a larger ecological model. While there are historical dimensions to the current situation, there are features of the contemporary situation that are distinctive as well. For one thing, we must recognize that the magnitude of the problem is different today. There has been a seven-fold increase in per capita aggravated assault rates among youth in the United States since 1956. Class, race, and gender exert important influences on exposure to community violence. There is psychologically relentless and usually destructive pressure imposed on kids who experience violence in the contexts community breakdown, family disruption, and personal experience of trauma.
Stress of Singlehood: Marital Status, Domain-Specific Stress, and Anxiety in a National U.S. Sample

The current study compared perceived stress among married and single individuals across a variety of life domains in order to understand (1) the relationship between marital status and psychosocial mechanisms of stress and (2) the degree to which stress experienced in different domains is associated with other health problems (i.e., anxiety). Using survey data from a large national U.S. sample (N = 6,955), we used multiple regression and mediation analyses to investigate the role of marital status on perceived stress associated with social commitments, family commitments, loneliness, and economy/money; and we examined how these domain-specific stressors influenced daily self-reported anxiety. Marital status was a significant predictor of perceived stress: singlehood was positively correlated with perceived stress, specifically the stresses associated with social commitments, loneliness, and economy/money. These domain-specific stressors also mediated the relationship between marital status and anxiety. Th...
Orthogonal and Sparse Chirp Division Multiplexing for MMW Fiber-Wireless Integrated Systems

Millimeter wave (MMW) bands provide enormous potential in accommodating the explosive mobile data traffic with an increased bandwidth. And fiber-wireless integration is feasible with reduced remote radio head complexity and improved performance by inter-cell coordination. Targeting on improving the wireless transmission reliability in ultra-reliable low-latency communication (URLLC) while maintaining high spectral efficiency in enhanced mobile broadband (eMBB) in 5G, we propose an orthogonal chirp division multiplexing modulation in MMW fiber-wireless integrated systems. By adjusting the sparsity in chirp assignment, we can dynamically and digitally switch between eMBB and URLLC, to serve different traffic patterns and requirements. Without significantly additional complexity in system architecture and DSP, we experimentally demonstrate better reliability to interferences and noises without losing the eMBB data rate or performance.
Care Coordination Services: A Description of an Alternative Service Model for At-Risk Families

ABSTRACTObjective: The objective of this article is to describe a care coordination model that includes promising practices which are supported by both practice-based and research-based evidence. This model was developed to address the gaps of other models, namely an emphasis on skill teaching with parents, the flexibility to adapt to the needs of youth with a wide variety of presenting problems, and model fidelity assessment tools to help scale up the program across multiple locations with fidelity. Method: We discuss preliminary administrative and outcome data from 898 youth served across eight locations. Results: Data suggest positive outcomes at departure from service, as well as 6 months and 12 months post case closure. Conclusion: Preliminary data indicate that youth with educational and behavioral health challenges can benefit from coordination of services that are both youth guided and family driven. As this program has been scaled up and has an established vehicle of dissemination, it is in a uni...
Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae

In asthmatic airways, repeated epithelial damage and repair occur. No current therapy directly targets this process. We aimed to determine the effects of mannan derived from S. cerevisiae (SC-MN) on airway epithelial wound repair, in vitro. The presence of functional mannose receptors in bronchial epithelial cells was shown by endocytosis of colloidal gold-Man BSA via clathrin-coated pits in 16HBE cells. In primary normal human bronchial epithelial cells (NHBEC), SC-MN significantly facilitated wound closure. Treatment with SC-MN stimulated cell spreading as indicated by a significant increase in the average lamellipodial width of wound edge 16HBE cells. In addition, NHBEC treated with SC-MN showed increased expression and activation of Kruppel-like factors (KLFs) 4 and 5, transcription factors important in epithelial cell survival and regulation of epithelial-mesenchymal transition. We conclude that SC-MN facilitates wound repair in human bronchial epithelium, involving mannose receptors.
A spatial analytic framework for assessing and improving food aid distribution in developing countries

Undernutrition is responsible for nearly half of all deaths of children under five years of age. In the developing world, where many communities rely on subsistence farming, one way of combating undernutrition is through food aid provided by governmental and non-governmental organizations. In this analysis we develop a flexible optimization based approach to support food aid planning capable of incorporating a variety of inputs to capture micro-scale food demand. We apply this optimization model to the specific case of Mali, one of the poorest countries in the world, with large food aid programs. The results are compared to the current distribution of food aid outlets as presented by the World Food Program and suggest that an optimization based framework provides quantitative-based insights of demand and resource allocation useful for planning efforts. In particular, the results indicate that a reallocation of existing food aid outlets towards more dense areas where vegetation is reduced could markedly increase access to outlets by those with food needs. The developed approach has potential to support ongoing efforts to reduce food insecurity and improve the cost-effective targeting of food aid in Mali and elsewhere.
Critical stage of nitrogen requirement for citrus fruit development

Nitrogen (N) requirement for citrus (Citrus sinensis) fruit growth and development was studied from June to December for Parson Brown, Hamlin, Valencia, and Sunburst orange varieties which received either 168, 224, or 280 kg N ha-1 yr-1. Fruit yield was not significantly influenced by the above N rates over the three years of study. Fruit diameter increased appreciably from June to September (32 to 57 mm for Sunburst, 44 to 70 mm for Parson Brown and Valencia, and 48 to 70 mm for Hamlin), followed by a slow increase until December. Fruit dry weight almost doubled from June to September and continued to increase slowly during the latter half of the growing period. Nitrogen content in the fruit increased from 107 to 217, 113 to 258, 131 to 315, and 134 to 269 mg per fruit between June to September for Hamlin, Sunburst, Valencia, and Parson Brown varieties, respectively. From the N management point of view, adequate availability of N is critical during early fruit development. On the basis of fruit weight and N in fruit, fruit production of 1235 boxes (Box = 40.8 kg) per hectare accounts for 66, 71, 73, and 81 kg N in the fruits, respectively, for Hamlin, Parson Brown, Sunburst, and Valencia orange varieties. This study demonstrates significant genotypic differences with respect to N requirement for fruit development.
Artifacts for Dynamic Analysis of Android Apps

We describe a set of artifacts for dynamic analysis of Android apps, including a dataset used in a dynamic characterization study, source code used for performing the study, an Android inter-app benchmark suite, and definition of Android behavioral metrics.
Integrated performance monitoring systems: Benefits, pitfalls, and prescriptions

Performance monitoring systems are typically designed to assess the achievement of a single program or agency. In recent years, there have been efforts to integrate programs addressing a particular policy area (e.g., workforce development). The evolving systems incorporate multiple programs, agencies, funding streams, service providers, information systems, and goals. The design of integrated performance monitoring systems requires applying measures, standards, and comparisons to multiple levels of assessment. The author differentiates between traditional and integrated performance monitoring systems, identifies the levels that must be addressed by integrated systems and the obstacles that must be overcome in developing them, and discusses the benefits of integrated performance monitoring systems.
Spacecraft Attitude Control

Today Voyager 1 is sending telemetry via Station 14 in California’s Mojave Desert, one of the Deep Space Network’s 70-meter diameter tracking antennas, to the handful of engineers responsible for the craft.
Oxidation of MnO(100) and NaMnO2 formation: Characterization of Mn2+ and Mn3+ surfaces via XPS and water TPD

Abstract The oxidation of clean and Na precovered MnO(100) has been investigated by X-ray photoelectron spectroscopy (XPS), low energy electron diffraction (LEED) and temperature programmed desorption (TPD) of adsorbed water. XPS results indicate that Mn3O4-like and Mn2O3-like surfaces can be formed by various oxidation treatments of clean and nearly-stoichiometric MnO(100), while a NaMnO2-like surface can be produced by the oxidation of MnO(100) pre-covered with multilayers of metallic Na. Water TPD results indicate that water adsorption/desorption is sensitive to the available oxidation states of surface Mn cations, and can be used to distinguish between surfaces exposing Mn2+and Mn3+ cations, or a combination of these oxidation states. Carbon dioxide and water TPD results from the NaMnO2-like surface indicate that pre-adsorbed water blocks the uptake of CO2, while water displaces pre-adsorbed CO2. No indication of a strong reactive interaction is observed between CO2, water and the NaMnO2-like surface under the conditions of our study.
From the Ashes: Identifying, Documenting, and Rebuilding the Herzogin Anna Amalia Bibliothek’s Fruchtbringende Gesellschaft Collections

In 2004, fire struck the Herzogin Anna Amalia Bibliothek ( HAAB ) in Weimar. The fire particularly affected its seventeenth-century collections, among them rich holdings of works associated with the Fruchtbringende Gesellschaft, the foremost seventeenth-century German cultural society. This article investigates the impact of the blaze, looking back over the decade that has elapsed since the event. Among the questions investigated are: what are the numbers of lost, damaged, and surviving volumes? What are the effects on the scholarly research community? How successful has the HAAB been in replacing lost Society editions? What roles have the HAAB ’s duplicates and restoration efforts played in the editions’ continued accessibility? How has, in sum, the significance of the library’s Fruchtbringende Gesellschaft holdings been altered due to the damage inflicted by an early twenty-first century disaster?
Effect of Magnesium Citrate and Magnesium Oxide on the Crystallization of Calcium Salts in Urine: Changes Produced by Food-Magnesium Interaction

AbstractThe effect of magnesium citrate and magnesium oxide on urinary biochemistry and on the crystallization of calcium salts was examined in 7 normal subjects and 4 patients with recurrent calcium oxalate nephrolithiasis. When magnesium citrate or magnesium oxide was administered on an empty stomach (10 mEq. 4 times per day or 486mg. magnesium per day for 2 weeks) urinary magnesium increased by only 77 to 79mg. per day and urinary citrate increased by 98 to 142mg. per day. However, urinary calcium increased by 21 to 25mg. per day. No significant changes were noted in urinary saturation of calcium oxalate or brushite or in the limit of metastability (formation product) of these salts. However, when magnesium salts were provided with meals there were more prominent increases in urinary magnesium (by 92 to 96mg. per day) and in citrate (by 218 to 226mg. per day). Moreover, urinary oxalate decreased. Owing to these changes the urinary saturation of calcium oxalate decreased and the formation product increa...
Computer-Based Accessible Testing System for Students with Visual Impairments and Learning Disabilities

Print-disabled individuals (e.g., visually impaired and specific learning disabilities) rely heavily on accessibility features for information input. For students with print disabilities, lack of accessibility to printed material creates a barrier for getting appropriate education and taking standardized online tests. Although various accessible testing software exist in the market, there is no standardized accessible testing system for high-stakes state-mandated tests. In this paper we present the design, implementation and evaluation of an accessible testing system (ATS) for high-stakes state-mandated tests. We also present results from various pilot studies of ATS which prove its efficacy.
Paediatric urology: Emerging challenges

Medical advancements in paediatric urology are moving at a rapid pace, understanding natural history in congenital malformation of the urinary tract in infancy has changed our diagnostic as well therapeutic approach. Additionally more efficient diagnostic options have evolved our therapeutic in particular surgical approach toward minimally invasive options in children. Interdisciplinary teamwork are the needs of the moment applies above all to children with complex congenital malformations such as disorders of sexual development, urethral valves, cloacal extrophy or complex congenital deformities of the upper urinary tract. This short summary give insights into the current diagnostic discussion as well minimal invasive concepts of most important disease patterns in paediatric urology.
Utilization of Chiropractic Care in US Children and Adolescents: A Cross-Sectional Study of the 2012 National Health Interview Survey

Abstract Objective The purpose of this study was to describe the prevalence of chiropractic utilization and examine sociodemographic characteristics associated with utilization in a representative sample of US children and adolescents aged 4 to 17 years. Methods Data are from 9734 respondents to the 2012 National Health Interview Survey. Age, sex, race/ethnicity, geography, family income, parental educational attainment, and other health care providers served as exposure variables. Chiropractic utilization in the past 12 months (yes/no) was the targeted outcome. Weighted crude and adjusted logistic regression models, controlling for relevant covariates, were performed. Results The 12-month prevalence of chiropractic utilization in US children was 3.0% (95% confidence interval: 2.6%-3.6%). The adjusted odds (95% confidence interval) of chiropractic utilization were higher among 11- to 17-year-olds (2.02 [1.41-2.90]) (vs 4- to10-year-olds), Midwest residents (2.45 [1.36-4.44]) (vs Northeast), families with incomes ≥$100 000 (3.25 [1.87-5.66]) (vs Conclusion Although overall prevalence was low, sociodemographic characteristics of child and adolescent users of chiropractic care were identified. Age, race/ethnicity, region of residence, family income, and utilization of other Complementary and Integrative Health services were associated with chiropractic utilization, after adjusting for sociodemographic covariates.
Say No to Rack Boundaries: Towards A Reconfigurable Pod-Centric DCN Architecture

Data center networks are designed to interconnect large clusters of servers. However, their static, rack-based architecture poses many constraints. For instance, due to over-subscription, bandwidth tends to be highly unbalanced---while servers in the same rack enjoy full bisection bandwidth through a top-of-rack (ToR) switch, servers across racks have much more constrained bandwidth. This translates to a series of performance issues for modern cloud applications. In this paper, we propose a rackless data center (RDC) architecture that removes this fixed "rack boundary". We achieve this by inserting circuit switches at the edge layer, and dynamically reconfiguring the circuits to allow servers from different racks to form "locality groups". RDC optimizes the topology between servers and edge switches based on the changing workloads, and achieves lower flow completion times and improved load balance for realistic workloads.
Injury-related treatments and outcomes in preschool children with autism spectrum disorder: Study to Explore Early Development (SEED)

Abstract Background Evidence about injury management and outcomes in children with autism spectrum disorder (ASD) is limited. Method Cross-sectional analyses included children aged 30–68 months with at least one medically attended injury. Standardized diagnostic instruments determined ASD cases. Parent-reported injury treatments and outcomes were examined in ASD cases (n = 224) versus developmental delays/disorders (DD) (n = 188) and population (POP) (n = 267) controls, adjusting for child and family characteristics using logistic regression. Results Injury characteristics were similar between groups. Most children (82.5%) had emergency care (EC) or hospitalization after injury. Nearly half (46.4%) ever received a medication or injection, mostly analgesics (53.4%) and local anesthetics (23.8%), while 9.4% ever received surgery, most often for open wound (47.0%) or fracture (16.7%). ASD group children were less likely than DD group children to receive medication/injection (41.1% vs. 53.2%, adjusted odds ratio [aOR] = 0.60 [0.40, 0.90]); receipt of EC/hospitalization and surgery were comparable. Children with ASD more often had surgery than POP children (14.3% vs. 4.9%, aOR = 2.62 [1.31, 5.25]); receipt of EC/hospitalization and medication/injection were similar. Loss of consciousness was uncommon (ASD = 6.3%, DD = 5.3%, POP = 3.4%), as was long-term or significant behavior change (ASD = 5.4%, DD = 3.2%, POP = 3.2%); differences were not significant. Conclusions Injured children with ASD received fewer medications/injections than children with non-ASD developmental delays/disorders and more surgical treatments than general population children. Injury management was otherwise similar between groups. Understanding whether these results reflect child or injury characteristics or provider perceptions about behaviors and pain thresholds of children with ASD, and how these may influence care, requires further study.
Relationship between different levels of the Mexican food environment and dietary intake: a qualitative systematic review.

OBJECTIVE To investigate the possible associations between the food environment and dietary intake in the Mexican population. DESIGN Four databases (PubMed, PsychInfo, Web of Science and SCIelo) were used to retrieve relevant articles using an open timeframe. Articles were reviewed if they contained a systematic measure (i.e. food checklist) of the food environment (e.g. food availability) and dietary intake. SETTING Urban and rural communities in Mexico. PARTICIPANTS Population-based studies of Mexican communities. RESULTS Twenty studies that assessed at least one food environment level, and at least one dietary outcome, were reviewed. Findings from these studies showed that changes in the Mexican food environment seem to be associated with higher availability of energy-dense foods. Energy-dense foods can be linked to a high consumption in household, environment and community food environments. When both nutrient-dense and energy-dense foods were present, individuals were more likely to consume foods with added sugars, fats and salt options than nutrient-dense items. CONCLUSIONS The various levels of the food environment (i.e. household, school, community) exposed participants to energy-dense foods. Although nutrient-dense foods were present in all three levels, individuals were more likely to consume energy-dense food items. Not all three levels of the food environment are well represented in the urban and rural settings. Most studies on the community food environment were done in rural areas, whereas most studies on the school food environment were done in urban settings. Additional rigorously designed studies are needed to document the relationship between the food environment and dietary intake in the Mexican population.
Long-term intra-arterial shunt

This is a case report of a patient who sustained a stab wound to the right axilla with injuries to the right axillary artery and vein. The patient had near-exsanguination in the field and no recordable blood pressure upon admission to the trauma center. Resuscitation was performed with endotracheal intubation, a left anterolateral resuscitative thoracotomy with cross-clamping of the descending thoracic aorta, and the rapid infusion of crystalloid solutions and packed red cells. In the operating room, the third portion of the right axillary artery and the adjacent right axillary vein were found to be transected. As part of a ‘damage control’ procedure, the ends of the right axillary vein were ligated. A 14 French intra-arterial shunt was inserted into the transected ends of the right axillary artery to restore the flow to the right upper extremity. The patient’s postoperative course was complicated by a coagulopathy, adult respiratory distress syndrome (ARDS), and anuria. The coagulopathy and anuria resolved within the first 48 hours, but the patient’s ARDS was slow to resolve. On the 10th postinjury day, the patient was returned to the operating room for a definitive repair of the right axillary artery. After the intra-arterial shunt was removed, a reversed greater saphenous vein graft was inserted between the ends of the right axillary artery in a medial intermuscular (extra-anatomic) tunnel. The patient made an uneventful recovery and was discharged home on the 16th postinjury day. The following principles of advanced trauma care were part of the management of this patient: (1) occasional need for resuscitative thoracotomy with cross-clamping of the descending thoracic aorta in a patient without a thoracic injury; (2) ‘damage control’ operation with ligation of the right axillary vein and placement of a temporary intra-arterial shunt to restore the flow to the right upper extremity; and (3) vascular reconstruction with an extra-anatomic bypass in a previously contaminated field.
Agent Programmability Enhancement for Rambling over a Scientific Dataset

Agent-based modeling (ABM), while originally intended for micro-simulation of individual entities, (i.e., agents), has been adopted to operations research as biologically-inspired algorithms including ant colonial optimization and grasshopper optimization algorithm. Observing their successful use in traveling salesman problem and K-means clustering, we promote this trend in ABM to distributed data analysis. Our approach is to populate reactive agents on a distributed, structured dataset and to have them discover the dataset’s attributes (e.g., the shortest routes and the best cluster centroids) through agent migration and interaction. We implemented this agent-based approach with the multi-agent spatial simulation (MASS) library and identified programming features for agents to best achieve data discovery. Of importance is ease of describing when and how to have agents traverse a graph, ramble over an array, and share the on-going computational states. We have responded to this question with two agent-descriptivity enhancements: (1) event-driven agent behavioral execution and (2) direct inter-agent broadcast. The former automatically schedules agent actions before and after agent migration, whereas the latter informs all agents of up-to-date global information, (e.g., the best slate of centroids so far). This paper presents our design, implementation, and evaluation of these two agent descriptivity enhancements.
The effect of lighting environment on task performance in buildings – a review

Abstract The effects of indoor environmental conditions on human health, satisfaction, and performance have been the focus of research for decades. This paper reviews and summarizes the impact of lighting environment on task performance, specifically for the built environment audience. Existing studies included a variety of performance tests on cognitive performance and perception, visual acuity and reaction, memory, reasoning, and labor productivity. Illuminance, luminance ratio and correlated color temperature were found to affect performance in different ways, reflecting the impact of experimental techniques, conditions, performance evaluation methods used and data analysis methods. These were reviewed and categorized, with discussion on limitations related to sample size, modeling approach, carryover effects and other factors affecting individual differences in performance, with recommendations for future improvement. Although no universal conclusions can be made, in general, task performance seems to improve with higher illuminances, contrast ratios in the range of 7-11:1 (while always making sure that glare will not occur in the space) and higher correlated color temperature, while spectral tuning in the red or blue wavelengths has also shown positive effects. To obtain more generic evidence, future studies should be more consistent in terms of experimental procedures and overall light conditions, and also consider the effects of vertical illuminance, daylight provision/control, and outside views on task performance. Finally, studying performance with multi-factorial designs in a human-centered optimized manner (such as deploying variable lighting scenarios optimized for various tasks) can lead to deeper understanding of lighting effects on task performance, and ultimately to improved lighting design and operation in buildings overall.
HVAC System Design Based on Electromechanical Technology Transformation

With the development of social and economic level, people pay more attention to environmental protection and energy conservation. In building energy consumption, the energy consumption produced by HVAC system occupies a high proportion, so the energy-saving measures and effects of HVAC system are widely concerned by society. The traditional HVAC system has some problems such as insufficient safety and environmental protection awareness, and the HVAC system based on mechanical and electrical technology transformation can solve these problems very well. Therefore, based on the design of HVAC system and the characteristics of mechatronics technology, the HVAC system based on mechatronics technology transformation is designed. The results show that compared with traditional HVAC system, the HVAC system based on mechatronics technology transformation has better performance.
A Model for Atomic Precision p-Type Doping with Diborane on Si(100)-2×1

Diborane (B2H6) is a promising molecular precursor for atomic precision p-type doping of silicon that has recently been experimentally demonstrated [Skereň Nat. Electron. 2020]. We use density func...
Vacatur of Awards Under the Tennessee Uniform Arbitration Act: Substance, Procedure, and Strategies for Practitioners

This article analyzes the Tennessee Uniform Arbitration Act (TUAA). One of the most challenging TUAA topics is the action for vacatur (annulment) of an arbitral award. Because actions for vacatur are often the most hotly-disputed matters between the arbitral parties, this article focuses on this subject to assist practitioners in developing strategies to advance their clients’ interests.
Cultivating a Culture of Care through Both/And Leadership.

As the nation’s personal, social, and political divides deepen and become more contentious, administrators, faculty, staff, and students face the challenge of navigating this division. Issues of hu...
KCNE Regulation of KCNQ Channels

Voltage-gated potassium (Kv) channels are perhaps best known for their roles in the action potentials of excitable cells, but they also fulfill a diverse array of vital roles in polarized epithelial cells. Much of the research and current knowledge in this area centers on the KCNQ1 potassium channel and the KCNE family of regulatory proteins. By exploiting the functional versatility endowed by forming complexes with single transmembrane-spanning KCNE subunits, KCNQ1 is able to serve a plethora of different roles in polarized epithelia and other tissues. This chapter is focused on the epithelial functions of KCNE proteins, with a major emphasis on regulation of KCNQ1 as this dominates our present knowledge in this field. In addition to outlining what is known about epithelial KCNE physiology, the chapter also covers KCNE pathobiology, as determined from human disease associations and Kcne knockout mouse studies.
Registered Reports in Special Education: Introduction to the Special Series:

This article introduces a special series of registered reports in Remedial and Special Education. Registered reports are an innovative approach to publishing that aim to increase the credibility of...
Lipid-extracted algae as a source of biomaterials for algae biorefineries

Abstract The repertoire of novel biobased materials is continually expanding as they represent green alternatives to carbon-intensive fossil materials. Lipid-extracted algae (LEA) biomass is a promising feedstock for the production of a spectrum of biobased materials, such as hydrochar and biochar, electrodes in microbial fuel cells (MFCs), supercapacitors, biocomposites, biopolymers, activated carbon including N-doping, and biosorbents. By selecting appropriate process conditions, these renewable products can be designed to possess desirable properties and, at the same time, be more sustainable. Most importantly, we view LEA as a potentially significant additional source of revenue for algae biorefineries that can accelerate the commercial development of algae. The present study assesses the utilization of LEA for the production of biobased materials, their applications and sustainability profile, and future trends.
Climate Risk Management

Accelerating global climate change drives new climate risks. People around the world are researching, designing, and implementing strategies to manage these risks. Identifying and implementing soun...
RECURRENT APHTHOUS STOMATITIS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME: A CASE REPORT

Objective The aim of this report is to present the process of diagnosis and management of a patient with myelodysplastic syndrome afflicted with recurrent aphthous stomatitis (RAS). Background RAS is one of the most common lesions of the oral mucosa seen in adolescents. Although the exact etiology of RAS is still unknown, different hematinic deficiencies have been proposed. Case Report A 71-year-old male patient with multicomorbidities suffered from frequent oral ulcerations for many years. Hematologic investigation showed normal iron serum concentration and higher folate levels. In addition, his serum zinc concentration was low. Although his vitamin B12 level was normal, his homocysteine level was slightly high. Furthermore, his red blood cell count, hemoglobin, and hematocrit were low, and mean corpuscular volume, mean corpuscular hemoglobin, and red blood cell distribution width were high, which were related to megaloblastic anemia. Treatment with prednisolone, zinc gluconate, hydroxocobalamin, and nystatin led to rapid improvement. Nevertheless, fluctuations in the state of his RAS occurred within 6 months. Hence, we consulted the Division of Hematology and Oncology for further evaluation. The hematology and oncology doctor arranged blood tests and bone marrow biopsy and prescribed ferrous gluconate-B. The bone marrow biopsy showed myelodysplastic syndrome, refractory cytopenia with multilineage dysplasia, and iron store deficiency. After iron supplementation, his recovery rate improved. Clinical Implication When patients have RAS, consider checking iron, vitamin B12, and folate levels and treating patients if levels are low. Such treatment could reduce some varieties of RAS. However, in patients with hematological diseases, further tests, such as bone marrow biopsy, may be needed.
Varying influence of phytoplankton biodiversity and stoichiometric plasticity on bulk particulate stoichiometry across ocean basins

Concentrations and elemental ratios of suspended particulate organic matter influence many biogeochemical processes in the ocean, including patterns of phytoplankton nutrient limitation and links between carbon, nitrogen and phosphorus cycles. Here we present direct measurements of cellular nutrient content and stoichiometric ratios for discrete phytoplankton populations spanning broad environmental conditions across several ocean basins. Median cellular carbon-to-phosphorus and nitrogen-to-phosphorus ratios were positively correlated with vertical nitrate-to-phosphate flux for all phytoplankton groups and were consistently higher for cyanobacteria than eukaryotes. Light and temperature were inconsistent predictors of stoichiometric ratios. Across nutrient-rich and phosphorus-stressed biomes in the North Atlantic, but not in the nitrogen-stressed tropical North Pacific, we find that a combination of taxonomic composition and environmental acclimation best predict bulk particulate organic matter composition. Our findings demonstrate the central role of plankton biodiversity and plasticity in controlling linkages between ocean nutrient and carbon cycles in some regions. Phytoplankton biodiversity and cellular acclimation to vertical nutrient flux ratio control particulate stoichiometry in the North Atlantic, according to field observations of cellular elemental stoichiometry across taxonomic groups and ocean basins.
Ergonomic considerations when slotting piece-pick operations in distribution centers.

Abstract Many warehouse slotting algorithms have overlooked worker ergonomics. This research aimed to develop ergonomics slotting guidelines based upon the back and shoulder postures and electromyographic (EMG) responses of the deltoid and erector spinae muscles when individual items are picked from, or full cases replenished to, different shelf heights In the first study of two studies, participants lifted small items representative of piece-pick tasks from seven shelf heights. In the second study, participants performed a simulated full case replenishment task in which they lifted boxes weighing between 2.7 and 10.9 kg from a cart into a flow rack. Shelf height significantly affected all postural and EMG variables and there was a trade-off between back and shoulder muscle activity across the varying shelf heights. Together, these studies were used to develop some general ergonomic slotting guidelines that could be implemented to reduce biomechanical load exposures experienced by distribution center workers.