cssi/SciSciGPT-SciSciNet huggingface dataset:
Knee pain and crouch gait in individuals with cerebral palsy: what impact does crouch-related surgery have?

Aim To investigate the effect of crouch-related surgery on knee pain in individuals with cerebral palsy. Method We retrospectively identified individuals with two three-dimensional gait analyses at baseline and follow-up visits. All individuals walked in crouch gait at baseline. Visits were 9 months to 42 months apart. Baseline knee pain, age, crouch-related surgery (yes/no), and minimum knee flexion at follow-up were entered into a logistic regression to predict follow-up knee pain. Results Thirty-two individuals (21 males, 11 females; mean [SD] age 12y 10mo [2y 5mo]; 8y 1mo-18y 7mo) received crouch-related surgery, while 19 were managed non-surgically. At baseline, knee pain prevalence was 38% in the surgical group and 21% in the non-surgical group. At follow-up, 34% of the surgical group and 16% of the non-surgical group had knee pain (odds ratio: 2.809, p=0.285). Interpretation Crouch-related surgery does not appear to decrease knee pain prevalence compared to a comparison group, based on this preliminary study. Further investigation of the roles of these procedures is indicated with regards to this patient-reported outcome. What this paper adds Approximately 38% of individuals undergoing crouch-related surgery had knee pain. Approximately 42% of individuals with baseline knee pain who had surgery still had knee pain 1 year postoperatively. Approximately 50% of those with baseline knee pain managed non-surgically still had knee pain 1 year later. Crouch-related surgery tended not to decrease knee pain prevalence 1 year postoperatively.
Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis: a network meta-analysis.

Background and study aims While several interventions may decrease risk of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, it remains unclear whether one strategy is superior to others. The purpose of this study was to compare the effectiveness of pharmacologic and endoscopic interventions to prevent post-ERCP pancreatitis among high-risk patients. Methods A systematic review was performed to identify randomized controlled trials from PubMed, Embase, Web of Science, and Cochrane database through May 2017. Interventions included: rectal non-steroidal anti-inflammatory drugs (NSAIDs), aggressive hydration with lactated ringerʼs (LR) solution, and pancreatic stent placement compared to placebo. Only studies with patients at high-risk for post-ERCP pancreatitis were included. Bayesian network meta-analysis was performed and relative ranking of treatments was assessed using surface under the cumulative ranking (SUCRA) probabilities. Results We identified 29 trials, comprising 7,862 participants comparing four preventive strategies. On network meta-analysis, compared with placebo, rectal NSAIDs (B = – 0.69, 95 % CI [–1.18; – 0.21]), pancreatic stent (B = – 1.25, 95 % CI [–1.81 to –0.69]), LR (B = – 0.67, 95 % CI [–1.20 to –0.13]), and combination of LR plus rectal NSAIDs (B = – 1.58; 95 % CI [–3.0 to –0.17]), were all associated with a reduced risk of post-ERCP pancreatitis. Pancreatic stent placement had the highest SUCRA probability (0.81, 95 % CI [0.83 to 0.80]) of being ranked the best prophylactic treatment. Conclusions Based on this network meta-analysis, pancreatic stent placement appears to be the most effective preventive strategy for post-ERCP pancreatitis in high-risk patients.
Pitch Estimation Via Self-Supervision

We present a method to estimate the fundamental frequency in monophonic audio, often referred to as pitch estimation. In contrast to existing methods, our neural network can be fully trained only on unlabeled data, using self-supervision. A tiny amount of labeled data is needed solely for mapping the network outputs to absolute pitch values. The key to this is the observation that if one creates two examples from one original audio clip by pitch shifting both, the difference between the correct outputs is known, without even knowing the actual pitch value in the original clip. Somewhat surprisingly, this idea combined with an auxiliary reconstruction loss allows training a pitch estimation model. Our results show that our pitch estimation method obtains an accuracy comparable to fully supervised models on monophonic audio, without the need for large labeled datasets. In addition, we are able to train a voicing detection output in the same model, again without using any labels.1
Identification of Environmental Factors that Influence the Likelihood of Off‐target Movement of Dicamba

Background Commercialization of dicamba-resistant soybean and cotton and subsequent post-emergence applications of dicamba contributed to at least 1.4 and 0.5 million hectares of dicamba-injured soybean in the United States in 2017 and 2018, respectively. This research was initiated to identify environmental factors that contribute to off-target dicamba movement. A survey was conducted following the 2017 growing season to collect information from dicamba applications that remained on the target field and those where dicamba moved. Weather and environmental data surrounding applications were collected and used to identify factors that reduce the likelihood of off-target movement. Soil pH was one factor identified in the model, and field experiments were conducted in 2018 and 2019 to validate the model. Three commercially-available dicamba formulations and one formulation currently in development were applied to soil at five distinct pH values. Sensitive soybean was used as a bioassay plant to detect dicamba volatilization. Results Wind speeds the day of and following application, nearest water source to the field, soybean production acreage in the county, and soil pH were identified as factors that influence the likelihood for off-target movement. In the field study, when dicamba was applied to pH-adjusted soil and placed under low tunnels for 72 h, dicamba volatility increased when soil pH decreased as the model predicted. Dicamba choline, which is not commercially available, had reduced volatility compared to other formulations tested. Conclusion Results of this study identified specific factors that contribute to successful and unsuccessful dicamba applications and should be considered prior to applications. © 2020 Society of Chemical Industry.
Beyond the Standard Model : The Effective Field Theory Approach

Since the 1970s, we have been witnessing the triumphs of the standard model of particle physics (SM) in describing the microscopic behavior of matter in terms of a few elementary constituents and fundamental interactions.
“I Need You to Show Me:” Coaching Early Childhood Professionals

In most states, Early Childhood Educators (ECEs) with a Birth-Kindergarten teaching license serve as both the general education teacher and special education teacher for children and their families in inclusive early childhood education (ECE) settings. Prior research suggests that inclusive programming does not guarantee these ECE settings are high-quality. Although evidence-based practices (EBP) and the Division of Early Childhood (DEC) Recommended Practices (RPs) have been established, a research-to-practice gap still exists in the inclusive, ECE classroom. Additional research indicates that coaching teachers may influence their implementation of EBPs in classrooms. This study provided early childhood educators (ECEs) the opportunity to share their perceptions about the support they receive from mentors and evaluators, as well as report the specific aspects of coaching needed to be successful while working in inclusive pre-kindergarten (Pre-K) classrooms. Qualitative research methods using an ethnomethodological framework were used to examine ECEs’ responses to semi-structured questions. Findings from this study can inform a prospective coaching model that includes explicit modeling, a deeply reflective component, and an array of professional development (PD) opportunities.
Acceptance of CRISPR-based technologies for clinical application: a thematic analysis of attitudes on novel gene therapies in undergraduates

CRISPR technologies are among the most powerful advancements in modern biology because they accurately manipulate the genomes of living cells and have the potential of curing various genetic diseas...
Heparin-induced thrombocytopenia in end-stage renal disease: Reliability of the PF4-heparin ELISA

Background Diagnosing heparin-induced thrombocytopenia (HIT) in patients with end-stage renal disease (ESRD) can be difficult, as they are frequently exposed to heparin and have multiple etiologies for thrombocytopenia. Objective To correlate 4T scores, IgG heparin-platelet factor 4 (PF4-heparin) ELISA results, and serotonin release assay (SRA) results in patients with ESRD. Methods We performed a retrospective review of patients with ESRD (creatinine clearance Results Of 254 patients with ESRD (92% on RRT), 29 patients (11.4%) had a positive PF4. Eleven (37.9%) had a confirmed diagnosis of HIT: 10 patients who met all of the above criteria, and one who met the 4T criteria and was treated for HIT but did not have SRA testing due to high clinical suspicion and a positive PF4 test. False-positive PF4 values occurred in 8 patients (27.5%). Of 10 (34.5%) indeterminant cases of patients with a negative SRA but intermediate to high 4T and positive PF4, only 3 patients were treated for HIT, whereas the other 7 were judged not to have HIT as assessed by the treating clinician. In patients with an intermediate to high 4T score and PF4 optical density > 0.4 but negative SRA, who were not treated for HIT, there were no adverse outcomes documented such as new or progressive thrombosis. Conclusion In our ESRD population, 4T scores and PF4 testing were not predictive of a clinical diagnosis of HIT.
Efficient Distributed Coin-tossing Protocols

Ben-Or and Linial (1985) introduced the full information model for coin-tossing protocols involving $n$ -processors with unbounded computational power using a common broadcast channel for all their communications. A bias- $X$ coin-tossing protocol outputs 1 with probability $X$ ; otherwise, it outputs 0 with probability ( $1-X$ ). A coin-tossing protocol's insecurity is the maximum change in the output distribution (in the statistical distance) that an adversary can cause. This work considers an adversary who monitors the protocol's communication and intervenes at most once by restarting the processor who just broadcast her message. For a given tolerance $\varepsilon$ , our objective is to use the minimum number of processors, ensuring that this adversary can only change the output distribution by at most $\epsilon$ . Historically, the “threshold coin-tossing protocols” have been optimal or asymptotically optimal against various adversary models. However, for our model, Khorasgani, Maji, and Mukherjee (2019) prove the existence of coin-tossing protocols that achieve the same tolerance as the threshold protocols using a smaller number of processors. Unfortunately, their protocol is not computationally efficient. Towards this objective, for any $x\in(0,1)$ and $n\in \mathbb{N}$ , this paper presents computationally efficient coin-tossing protocols approximating the new protocols of Khorasgani, Maji, and Mukherjee (2019). This protocol's running time is linear in the inverse of the accuracy parameter of this approximation, which can be set arbitrarily small.
Application of Change Point Analysis of Response Time Data to Detect Test Speededness

Computer-based and web-based testing have become increasingly popular in recent years. Their popularity has dramatically expanded the availability of response time data. Compared to the conventiona...
Behavior of Reinforced Concrete Under Repeated Load

An experimental investigation of strains, stresses, crack widths and end slips in axially reinforced concrete prisms subjected to repeated tension loads is presented. Cylindrical specimens were reinforced with deformed steel bars. To obtain the strain distribution along the length of the bars, these were sectioned longitudinally, grooved for installation of 30 strain gages along the length, and after wiring the gages, the sections were rewelded to form instrumented bars with effectively undisturbed exterior. The specimens were subjected to repeated loads at different stress levels. Residual effects after unloading and changes in strain distribution which results from prior loading history are analyzed. Results show that effectiveness of stress transfer between concrete and steel depends primarily on the magnitude of the previous maximum load. The greater the magnitude of this load, the lesser is the effectiveness of stress transfer at subsequent lower stress levels. Analytical evaluations of the effects of shrinkage and tension loading are also presented. The results of these evaluations give an insight into the phenomena of cracking and stress transfer between steel and concrete.
Images of Individuation: A Jungian Approach to the Psychology of Imagery

Jung is not generally appreciated as a pioneer in the study of imagery. Yet Jung dedicated his life to understanding the relationship between imagery and psychological development, a process he called individuation (Jung, 1916a, 1916b, 1933, 1939, 1945, 1967, 1968a, 1968b, 1970). In the course of these studies he made three important discoveries. First, that images serve to compensate for the limited perspective of our conscious awareness. Second, that there is a patterned series of images which parallel the individuation process. Third, that cultivating and attending to these images can facilitate the process of individuation.
Formalized structured analysis specifications

Specifications define systems. The definition of a system can be stated casually or formally. A formal specification is a mathematically precise definition of software functionality. Informal specifications are less precise definitions of software functionality. The benefits of formal specifications are clear. Arguments against the use of formal specifications have been refuted. Several formal specification techniques are available for specifying imperative programs, e.g., Z, VDM, and SPECS. Most specification techniques for distributed/concurrent systems concentrate on low level issues, e.g., deadlock and synchronization. Structured Analysis (SA) specifications are a popular informal specification technique, but they lack a rigorous mathematical semantics. SA specifications are based on a graphical syntax with little underlying formal structure. In this thesis, we identify and formalize those underlying structures that are represented informally, provide a formal definition of a SA specification, develop formal interpretations for those components of SA specifications that are subject to varying interpretation, and define an operational semantics for animating SA specifications. The resulting formalized SA specifications are mathematically precise and can be used to specify distributed/concurrent systems.
Presynaptic and Postsynaptic Mechanisms of a Novel Form of Homosynaptic Potentiation at Aplysia Sensory-Motor Neuron Synapses

Previous studies have shown that homosynaptic potentiation produced by rather mild tetanic stimulation (20 Hz, 2 sec) at Aplysia sensory-motor neuron synapses in isolated cell culture involves both presynaptic and postsynaptic Ca2+ ([Bao et al., 1997][1]). We have now investigated the sources of Ca2+ and some of its downstream targets. Although the potentiation lasts >30 min, it does not require Ca2+ influx through either NMDA receptor channels or L-type Ca2+ channels. Rather, the potentiation involves metabotropic receptors and intracellular Ca2+ release from both postsynaptic IP3-sensitive and presynaptic ryanodine-sensitive stores. In addition, it involves protein kinases, including both presynaptic and postsynaptic CamKII and probably MAP kinase. Finally, it does not require transsynaptic signaling by nitric oxide but it may involve AMPA receptor insertion. The potentiation, thus, shares components of the mechanisms of post-tetanic potentiation, NMDA- and mGluR-dependent long-term potentiation, and even long-term depression, but is not identical to any of them. These results are consistent with the more general idea that there is a molecular alphabet of basic components that can be combined in various ways to create novel as well as known types of plasticity. [1]: #ref-5
Vegetative propagation of Inga feuillei from shoot cuttings and air layering

Cuttage and air layering were evaluated as means of vegetative propagation of the tropical woody tree, Inga feuillei. Effects of moisture management systems, leafiness, auxin application, and stem diameter on rooting of semihardwood cuttings were investigated. Cuttings were taken from 2-year-old seed-propagated, greenhouse-grown stock plants. Compound leaves were either reduced in area or removed entirely before auxin pretreatment with 0, 0.3, or 0.8% indolebutyric acid (IBA) followed by sticking under mist or in a polyethylene enclosure. Leafless cuttings did not root regardless of moisture management system or auxin pretreatment, whereas 55% rooting of leafy cuttings was observed. Leafy cuttings rooted significantly better under mist than in a polyethylene enclosure. Auxin treatment at the higher level increased rooting percentage approximately two fold for larger diameter cuttings (8.1 to 20 mm), but had no effect on the smaller cuttings (2 to 8 mm), and resulted in an approximately three fold increase in the number of roots/rooted cutting for both stem diameter classes. Auxin treatment did not affect rooting percentage of leafy softwood cuttings under fog, however it did increase the number of roots per rooted cutting. One hundred percent of air layered shoots rooted within 5 weeks with or without auxin pretreatment, and all rooted layers survived transplanting to soil. Possible implications of this research on agroforestry, selection, genetic improvement, and conservation are discussed.
A globally convergent algorithm for MAP estimation in the linear model with non-Gaussian priors

We develop a framework for analyzing non-Gaussian densities in terms of the curvature of the density function itself rather than moments of the random variable. The framework suggests a new criterion for sub- and super-gaussianity of densities that is seen to be of a wider range of application than the commonly used kurtosis criterion. We show that the notion of relative curvature introduced can be seen as a generalization of the notion of convexity, where classical convexity of a function is seen as a relationship between the function and a linear model. We use the curvature framework to derive an inequality that holds for all functions that are super-Gaussian in the sense of the proposed criterion. This inequality allows proof of global convergence of a certain re-weighted minimum norm algorithm by providing a weighting matrix that yields descent without line search. The algorithm is equivalent to the FOCUSS algorithm (Rao, B.D. and Gorodnitsky, I.F., IEEE Trans. Sig. Processing, vol.45, p.600-6, 1997; Rao and Kreutz-Delgado, K., IEEE Trans. Sig. Processing, vol.47, p.187-200, 1999) in the case of independent generalized Gaussian densities in the linear model.
Salmonellae as an Index of Pollution of Surface Waters

Screening enrichments of surface water specimens by means of a polyvalent fluorescent antibody reagent for the salmonellae yielded approximately 60% more positive specimens than was obtained by cultural procedures. It is not known what fraction of the excess of fluorescent antibody-positive over culturally positive specimens represents staining of non-salmonellae or non-arizonae as opposed to the staining of non-cultivatable organisms of these two genera. Cotton gauze and rayon-polypropylene fiber swabs were equally sensitive for collecting salmonellae from the streams examined. Tetrathionate enrichment incubated at 41.5 C appeared to be superior to selenite-cystine for isolation of salmonellae from surface waters. Twenty-eight serotypes of Salmonella and two serotypes of Arizona were identified in the 121 positive specimens. In water rated moderately polluted, 65% of all specimens tested were positive; in minimally polluted waters, 38% were positive; and in unpolluted streams, 44% were positive.
Comparative Chronic Valve and Venous Effects of Lumenless versus Stylet‐Delivered Pacing Leads in Patients with and Without Congenital Heart

Background Standard, 5–7-Fr diameter pacing leads (PLs) can adversely affect atrioventricular valve (AVV) and venous (superior vena cava [SVC], innominate [INN]) integrities. Although chronic pacing/sensing performances have been reported on the steroid-eluting, lumenless, 4.1-Fr PL (Model 3830, Medtronic Inc., Minneapolis, MN, USA), comparative valve and venous effects are largely unknown. Methods Patients (n = 134) were divided into two PL groups: Group 1 (n = 65, Model 3830) and Group 2 (n = 69, various 5–7 Fr models) and followed up to 9 years postimplant. Patient demographics, clinical findings, valve function, and venous dimensions were reviewed. Statistical significance was defined as P < 0.05. Results Patient implant age (mean 16.4 years vs 17.3 years), presence of congenital heart defect (CHD), and preexisting valve issues were comparable between groups. New or worsening valve insufficiency occurred in 12% of Group 1 patients (mean follow-up 4.3 ± 2.8 years) and 27% of Group 2 patients (mean follow-up 6.2 ± 3.5 years; P < 0.05). Significant SVC or INN narrowing was found in 11 % of Group 1 and 24% of Group 2 patients (P = 0.0004). All Group 1 patients <12 years of age showed normal while 50% of those from Group 2 exhibited stunted SVC or INN growth (P < 0.05). Conclusion The lumenless, 4.1-Fr diameter PL offers improved clinical benefits, better AVV integrity, and venous development compared with larger 5–7-Fr diameter PL and should be considered especially in younger patients with/without CHD.
Java wildcards meet definition-site variance

Variance is concerned with the interplay of parametric polymorphism (i.e., templates, generics) and subtyping. The study of variance gives answers to the question of when an instantiation of a generic class can be a subtype of another. In this work, we combine the mechanisms of use-site variance (as in Java) and definition-site variance (as in Scala and C#) in a single type system, based on Java. This allows maximum flexibility in both the specification and use of generic types, thus increasing the reusability of code. Our VarJ calculus achieves a safe synergy of def-site and use-site variance, while supporting the full complexities of the Java realization of variance, including F-bounded polymorphism and wildcard capture. We show that the interaction of these features with definition-site variance is non-trivial and offer a full proof of soundness--the first in the literature for an approach combining variance mechanisms.
Present and future approaches for the control of caries.

This article summarizes current and potential future approaches for the management of caries. Current surveys suggest that traditional “drill, fill, and bill” dentistry is still widely practiced in the United States in spite of considerable evidence that supports a minimally invasive treatment approach. Because there is a wide variability in treatment decisions on when and how to prevent new lesions, on how to arrest the progression of existing lesions, and on when and how to place initial and replacement restorations, the findings from some studies differ significantly from the results of other studies. While fluoride treatments are known to prevent a percentage of new lesions, they do not have the ability to prevent all caries lesions. Modern management of caries entails treating patients according to risk and monitoring early lesions in tooth surfaces that are not cavitated. Although we know that the dmfs score for children is a powerful predictor of caries increment in permanent teeth of these children a few years later, this score is rarely used in private practice as a measure of risk or as a measure of treatment success. Although these modern methods for caries management offer great promise for controlling the disease, they may take decades to apply in a standardized way so that the variability in treatment is reduced. However, during the next two decades, an alternative approach to caries prevention such as replacement therapy and a caries vaccine may become available as a more consistent method of controlling this disease.
Preferred Orientation of Olivine Crystals in Porphyritic Chondrules

Abstract Ten porphyritic chondrules from the Hallingeberg and Krymka chondrites were examined on the universal stage to determine whether their olivine phenocrysts show preferred shape orientation. From 50 to 150 olivine crystals were examined in each chondrule. In nine of the ten chondrules studied, the largest crystals (larger than about 0.1 mm) show a distinct preferred orientation of the longest (β) axes indicative of a planar orientation and a linear alignment in the plane of foliation; the small crystals in each chondrule show a weak preferred orientation or none. The olivine fabrics in these chondrules resemble mineral fabrics found in the Moore County eucrite and in terrestrial basic intrusive rocks. They are readily explained by motion within a partly crystalline silicate melt, and they suggest that chondrules were drawn from one or more extended magma bodies and did not form and crystallize as separate entities in space.
Abstract 3495: Targeting gliomas with a dual kinase inhibitor and stem-cell delivered TRAIL

Gliomas are difficult to eradicate due to several factors: a) the lack of efficient delivery of anti-tumor agents to the tumors without affecting the normal brain tissue; b) the inherent or acquired resistance of tumor cells to anti-tumor agents; and c) the highly invasive nature of tumor cells that escape the primary tumor mass and subsequently cause recurrence. We previously established that a secreted form of tumor necrosis factor-related apoptosis inducing ligand (S-TRAIL) specifically eradicates glioma cells when delivered by various stem cell types in culture and in orthotopic glioma models. However, recent evidence has shown that a number of established and primary glioma lines have varying degrees of resistance to TRAIL, due to the heterogeneity of genetic alterations and possibly due to the over-activation of phosphatidylinositol 3 kinase (PI3K) pathway. In this study, we report the effect of a novel PI3K inhibitor, PI-103, alone or in combination with neural stem cell (NSC)-delivered S-TRAIL in mouse models of malignant and invasive gliomas. Using established and primary CD133+ glioma initiating cells engineered to express fluorescent and bioluminescent markers, we show that PI-103 alone inhibits proliferation and invasion, and causes G0-G1 arrest in cell cycle of most of the glioma cells tested. Furthermore, PI-103 augments the response of glioma cells to stem cell delivered S-TRAIL in co-cultures of NSCs and glioma cells suggesting that it can synergize with S-TRAIL-induced apoptosis. Using orthotopic malignant glioma models and bioluminescence imaging, PI-103 treatment in combination with NSC-derived S-TRAIL was shown to result in significant reduction in tumor volumes compared to either treatment alone in vivo. Our results reveal that combination of the novel PI3K inhibitor, PI-103, and stem cell delivered TRAIL might represent a novel therapy for malignant gliomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3495.
Kinetic energy distributions of sputtered neutral aluminum clusters: A1-A16

Abstract Neutral aluminum clusters sputtered from polycrystalline aluminum were analyzed by laser postionization time-of-flight (TOF) mass spectrometry. The kinetic energy distributions of Al through Al 6 were measured by a time-of-flight technique. The interpretation of laser postionization TOF data to extract velocity and energy distributions is presented. The aluminum cluster distributions are qualitatively similar to previous copper cluster distribution measurements from our laboratory. In contrast to the steep high energy tails predicted by the single- or multiple-collision models, the measured cluster distributions have high energy power law dependences in the range of E −3 to E −4.5 . Correlated collision models may explain the substantial abundance of energetic clusters that are observed in these experiments. The possible influences of cluster fragmentation on the distributions are discussed.
A theoretical study of the electric dipole moment function of SiO

Abstract A globally accurate electric dipole moment function (EDMF) is computed for the SiO molecule using large one-particle basis sets and an extensive treatment of electron correlation. A small translation of the EDMF brings the computed dipole moments for v=0–3 into good agreement with the highly accurate experimental values. The Einstein coefficients for the 1-0 fundamental and especially the 2-0 overtone band are significantly larger than the currently accepted values. Implications for astronomical measurements are discussed.
Street names and the scaling of memory: the politics of commemorating Martin Luther King, Jr within the African American community

Streets named for Martin Luther King, Jr are common yet controversial features in cities across the United States. This paper analyses the politics of naming these streets as a 'scaling of memory' - a socially contested process of determining the geographic extent to which the civil rights leader should be memorialized. Debates over the scaling of King's memory revolve around the size of the named street, the street's level of prominence within a hierarchy of roads, and the degree to which the street transcends the spatial confines of the black community. A street-naming struggle in Eatonton, Georgia (USA) exposes how the scaling of memory can become a point of division and contest within the black community as activists seek to fulfil different political goals. Analysing these intra racial contests allows for a fuller appreciation of the historical consciousness and geographic agency of African Americans rather than seeing them as a single, monolithic group.
Qualitative and quantitative co-occurrence of terpenoids as a tool for elucidation of their biosyntheses

Abstract A mathematical and conceptual framework has been developed for the utilization of qualitative and quantitative co-occurrence of natural compounds in establishing biosynthetic hypotheses. The methods were applied to a series of cases of co-occurrence of monoterpenoids, and the results were utilized for substantiation and clarification of our ideas on the biosyntheses of α- and β-pinene, β-phellandrene, camphene, tricyclene, bornyl acetate, γ-terpinene, α-thujene, sabinene, terpinolene, 3-carene, limonene and myrcene.
Inverted Polymer Solar Cells

Inverted bulk heterojunction polymer solar cells have become the preferred device architecture for roll-to-roll (R2R) processing, which allows large area devices to be fabricated on flexible substrates. Significant improvements in inverted solar cell performance have been made with novel photovoltaic polymers, along with optimized blend morphology and improved carrier extraction materials. For the first time, inverted polymer solar cells display their potential for low-cost R2R processing with power conversion efficiencies exceeding 8%.
Associations of family-centered care with health care outcomes for children with special health care needs.

The objective of this study is to examine the association of family-centered care (FCC) with specific health care service outcomes for children with special health care needs (CSHCN). The study is a secondary analysis of the 2005–2006 National Survey of Children with Special Health Care Needs. Receipt of FCC was determined by five questions regarding how well health care providers addressed family concerns in the prior 12 months. We measured family burden by reports of delayed health care, unmet need, financial costs, and time devoted to care; health status, by stability of health care needs; and emergency department and outpatient service use. All statistical analyses used propensity score-based matching models to address selection bias. FCC was reported by 65.6% of respondents (N = 38,915). FCC was associated with less delayed health care (AOR: 0.56; 95% CI: 0.48, 0.66), fewer unmet service needs (AOR: 0.53; 95% CI: 0.47, 0.60), reduced odds of ≥1 h/week coordinating care (AOR: 0.83; 95% CI: 0.74, 0.93) and reductions in out of pocket costs (AOR: 0.88; 95% CI: 0.80, 0.96). FCC was associated with more stable health care needs (AOR: 1.11; 95% CI: 1.01, 1.21), reduced odds of emergency room visits (AOR: 0.90; 95% CI: 0.82, 0.99) and increased odds of doctor visits (AOR: 1.25; 95% CI: 1.14, 1.37). Our study demonstrates associations of positive health and family outcomes with FCC. Realizing the health care delivery benefits of FCC may require additional encounters to build key elements of trust and partnership.
The contemporary present and modernist past in postcolonial African art

This article addresses ‘modern’ and ‘contemporary’ as two distinct categories in African artistic practices and art history. It engages with exhibitions as sites of knowledge production and examines how they construct narratives of artistic modernism, modernity, and contemporaneity. By focusing on the Tendances et Confrontations exhibition, at the Premier Festival Mondial des Arts Negres Dakar in 1966, and Dak'Art biennials since 1992, it explores the role of the two exhibition platforms in shaping artistic practices and discourse in two moments in African art and history in the last 50 years. The article also places particular emphasis on the interpretation of artworks in Tendances et Confrontations and Dak'Art to outline a transformation in artistic practices and knowledge production.
Intraoperative imaging: does it really improve perioperative outcomes of carotid endarterectomy?

A variety of intraoperative imaging and assessment techniques can be used during carotid endarterectomy (CEA) to evaluate the technical results of the arterial repair. However, the necessity of utilizing these techniques routinely in every case, and the actual ability of these studies to improve the outcomes of the operation, remain areas of controversy. The most commonly used intraoperative assessment techniques include arteriography, duplex ultrasonography, and use of a hand-held continuous-wave Doppler probe. While surgeons who advocate intraoperative imaging presume that it will ultimately improve the technical “perfection” of the operation by allowing the intraoperative identification and immediate revision of occult technical defects that would likely predispose toward perioperative stroke, there is little comparative data in the literature to support this premise. Proponents of routine intraoperative assessment argue that the identification of technical imperfections will allow their immediate correction prior to a perioperative stroke resulting from thromboembolization. In addition, surgeons who use these techniques believe that the presumed reduction in rate of serious technical errors will also result in a lower rate of recurrent carotid stenosis. However, many experienced vascular surgeons who perform CEA do not routinely utilize any of these intraoperative assessment techniques, and report equally excellent results using meticulous technique alone and clinical inspection of the endarterectomy site and arterial repair. Potential issues that may arise when performing routine intraoperative assessment can include: making a determination of which type of “imperfections” actually require immediate revision of the arterial repair, and potential vascular injuries or cerebral ischemia associated with reclamping of the artery in order to perform an immediate revision. In an analysis of a large, population-based cohort study of CEAs, the authors have found no compelling evidence that routine use of these imaging techniques confers any advantage in terms of the perioperative outcomes of carotid endarterectomy. Conclusions: the majority of surgeons who perform carotid endarterectomy do not routinely utilize any formal intraoperative completion imaging or assessment technique during CEA, other than clinical inspection of the arterial repair. However, even among vascular surgeons, less than 50% are routinely using intraoperative imaging or assessment. The routine use of intraoperative imaging studies did not appear to significantly improve perioperative outcomes with regard to ipsilateral perioperative stroke, and stroke/death. Considering the increased time and cost of performing these procedures, routine use of intraoperative imaging and assessment techniques during CEA is of questionable value. Selective use of these imaging or assessment techniques when the surgeon has a specific concern regarding the technical outcomes of the operation appears to be a reasonable alternative.
Does lack of tocopherols and tocotrienols put women at increased risk of breast cancer

Breast cancer is the leading site of new cancers in women and the second leading cause (after lung cancer) of cancer mortality in women. Observational studies that have collected data for dietary exposure to alpha-tocopherol with or without the other related tocopherols and tocotrienols have suggested that vitamin E from dietary sources may provide women with modest protection from breast cancer. However, there is no evidence that vitamin E supplements confer any protection whatever against breast cancer. Observational studies that have assessed exposure to vitamin E by plasma or adipose tissue concentrations of alpha-tocopherol have failed to provide consistent support for the idea that alpha-tocopherol provides any protection against breast cancer. In addition, evidence from studies in experimental animals suggest that alpha-tocopherol supplementation alone has little effect on mammary tumors. In contrast, studies in breast cancer cells indicate that alpha- gamma-, and delta-tocotrienol, and to a lesser extent delta-tocopherol, have potent antiproliferative and proapoptotic effects that would be expected to reduce risk of breast cancer. Many vegetable sources of alpha-tocopherol also contain other tocopherols or tocotrienols. Thus, it seems plausible that the modest protection from breast cancer associated with dietary vitamin E may be due to the effects of the other tocopherols and the tocotrienols in the diet. Additional studies will be required to determine whether this may be the case, and to identify the most active tocopherol/tocotrienol.
Feasibility of Aseptic Processing of a Low‐Acid Multiphase Food Product (salsa con queso) Using a Continuous Flow Microwave System

Aseptic processing of a low-acid multiphase food product using a continuous flow microwave heating system can combine the advantages of an aseptic process along with those of microwave heating. Dielectric properties of 2 different brands of 1 such product (salsa con queso) were measured under continuous flow conditions at a temperature range of 20 to 130 degrees C. At 915 MHz, the dielectric constant ranged from 58.7 at 20 degrees C to 41.3 at 130 degrees C with dielectric loss factor ranging from 41.0 at 20 degrees C to 145.5 at 130 degrees C. The loss tangent at 915 MHz ranged from 0.61 at 20 degrees C to 3.52 at 130 degrees C. The temperature profiles at the outlet during processing of salsa con queso in a 5-kW microwave unit showed a narrow temperature distribution between the center and the wall of the tube. The study showed the feasibility of aseptic processing of salsa con queso using a continuous flow microwave system.
Kaiser Permanente Northern California sepsis mortality reduction initiative

In 2008, Kaiser Permanente Northern California (KPNC), which provides care to 3.3 million members in 21 hospitals, implemented an initiative to improve sepsis care, a critical step to reduce hospital mortality. The goals of the program were threefold: improve identification of sepsis patients, appropriately stratify risk, and reliably provide treatment, focusing on spread and sustainability across all medical centers.
OLDER IMMIGRANTS AND U.S. WELFARE REFORM

U.S. welfare policy is undergoing a philosophical shift resulting in a dramatic legislative overhaul aimed at reducing spending, limiting eligibility, and enhancing the control of states over federal social service programs. To date, lawfully admitted permanent aliens have been treated the same as citizens by a host of federal programs for the poor. New legislation, however, would make noncitizens largely ineligible for public benefits. Programs that serve as a safety net for citizens would be recast as an earned right for noncitizens. This paper examines the implications for elderly aliens, a population that has grown in response to the liberalization of U.S. immigration laws. To assess the impact of changes in eligibility requirements for Supplemental Security Income, the paper focuses on California, the nation's most populous state and a leading destination of immigrants. The feasibility of individual adaptations to loss of benefits‐family support, employment, naturalization, and emigration‐is examined.
Ovarian influences on food intake and body weight regulation in lactating rats

In the following experiments, an attempt was made to determine the role of the ovary in the control of food intake and body weight regulation during lactation. In the first study, it was found that concentrations of estradiol benzoate effective in suppressing food intake and body weight in nonlactating animals were not effective during lactation. In the second experiment, ovariectomy during lactation was shown not to produce the usual increases in food intake and body weight or change in meal patterns known to occur after ovariectomy in the nonlactating rat. These results suggested that lactating animals behave the as though functionally ovariectomized and that the removal of the ovaries is of no additional consequence. The further observation that animals nursing small litters gained weight considerably more rapidly than animals nursing large litters led to the prediction that these animals would also be more responsive to the suppressive effects of EB. In the third study, EB in concentrations which are not effective in suppressing body weight in animals nursing large litters was found to suppress body weight in mothers with small litters. However, since these animals also showed a decline in milk yield, a number of alternative interpretations of these results were considered. These results, together with data concerning levels of ovarian hormones during gestation and lactation led to the hypothesis that pregnant and lactating animals undergo an elevation in body weight set-point, similar in magnitude and quality to elevations following ovariectomy in the nonlactating animal.
Antibiotics and the management of preterm premature rupture of the fetal membranes

Preterm premature rupture of membranes remains an important cause of preterm birth and neonatal morbidity and mortality. Although the underlying pathophysiology remains largely undefined, subclinical infection has been implicated both in the mechanism of membrane rupture and the resultant neonatal morbidity. The use of maternal systemic antibiotics reduces both neonatal and maternal morbidity in the expectant management of PPROM. Although concern persists over the development of resistant strains of organisms involved with neonatal sepsis, current data support the use of antibiotics in this setting. Further study is needed regarding the risks and benefits of additional tocolytic therapy or antenatal corticosteroids in the management of PPROM, and the predictors of successful and unsuccessful conservative management, and subclinical intrauterine infection. This will be helpful in the ultimate delineation of the optimal management scheme for PPROM.
Reform and the languages of renaissance theoretical medicine: Harvey versus Fernel.

Near the end of his last major treatise, De generatione animalium (1651), William Harvey confronts for one final time the vexing philosophical difficulties attending the physiological activity and generation of living organisms.' Harvey's analysis results in an overt, if somewhat speculative and incomplete, theory of living matter that complements his noted insistence on the primacy and inherent vitality of the blood.2 This theory of matter more precisely, some extraordinarily suggestive musings about living matter is framed by Harvey's rejection of alternative explanations of vital activity. With force and telling specificity, he informs us that
Targeting tyrosine kinase genes and long-term potentiation

Abstract With recent technical advancements in mouse embryology and in DNA recombination, it is now possible to engineer specific mutations in any gene within the mouse genome. With this powerful new genetic strategy the functional significance of a single gene can be studied at the molecular, cellular and behavioral levels, allowing a multifaceted investigation of complex neurobiological problems such as the cellular and molecular basis of learning and memory. In this review we will describe the use of targeted gene disruption to study roles of nonreceptor tyrosine kinases in the biochemical processes underlying long-term potentiation (LTP), a candidate cellular mechanism of learning and memory.
The Effects of Volume and Surface Area on the Rate of Accumulation of Solids in Indoor Manure Digestion Tanks

Abstract IN 1960, Owings and Adams (1961) initiated experiments involving the use of “indoor lagoons” or digestion tanks for collecting and storing poultry manure. This work was apparently the first report by an experiment station where poultry manure was collected and held under liquid. Their tank allowances were 2.5 cu. ft. and 288 sq. in. of surface per bird. It is conceivable that several physical conditions, heat, aeration, surface area and cubage, might affect the rate of dry matter accumulation. Since most pumping arrangements can handle only up to 20% solids, the rate of dry matter accumulation is closely associated with time between cleanouts. Some of the above factors (heating and aeration) have been studied by Al-Timimi et al. (1964), but only one cubage (3.5 cu. ft./bird) and one surface allowance (256 sq. in./bird) were reported. The present report investigates the effects of several cubage and surface allowances (Table 1). EXPERIMENTAL…
Endpoint Distinctiveness Facilitates Analogical Mapping in Pigeons

Analogical thinking necessitates mapping shared relations across two separate domains. We investigated whether pigeons could learn faster with ordinal mapping of relations across two physical dimensions (circle size & choice spatial position) relative to random mapping of these relations. Pigeons were trained to relate six circular samples of different sizes to horizontally positioned choice locations in a six alternative matching-to-sample task. Three pigeons were trained in a mapped condition in which circle size mapped directly onto choice spatial position. Three other pigeons were trained in a random condition in which the relations between size and choice position were arbitrarily assigned. The mapped group showed an advantage over the random group in acquiring this task. In a subsequent second phase, relations between the dimensions were ordinally reversed for the mapped group and re-randomized for the random group. There was no difference in how quickly matching accuracy re-emerged in the two groups, although the mapped group eventually performed more accurately. Analyses suggested this mapped advantage was likely due to endpoint distinctiveness and the benefits of proximity errors during choice responding rather than a conceptual or relational advantage attributable to the common or ordinal mapping of the two dimensions. This potential difficulty in mapping relations across dimensions may limit the pigeons' capacity for more advanced types of analogical reasoning. This article is part of a Special Issue entitled: Tribute to Tom Zentall.