cssi/SciSciGPT-SciSciNet huggingface dataset:
Ocular Coherence Tomography Macular Volume Predicts Walking Speed in Patients with Multiple Sclerosis (P6.305)

Objective:To correlate retinal thickness with walking speed in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). Background:Optical coherence tomography (OCT) is a technique using near-infrared light to examine and measure the thickness of the layers of the retina. It is used in patients with MS to objectively quantify the effects of optic neuritis, monitor disease progression, and assess for disease modifying therapy side effects. Methods: This was a retrospective, observational study of patients diagnosed with MS or CIS. A clinic database and electronic medical record were used to identify patients with an OCT, timed 25 foot walk, and visual acuity performed within 3 months. The Spearman correlation matrix was computed among the variables, including OCT findings (retinal nerve fiber layer thickness, ganglion cell and inner plexiform layer thickness, and macular volume), visual acuity, timed 25 foot walk, and age. A univariate analysis identified statistically significant variables to evaluate the overall significance of each variable. A multivariate analysis was then performed to determine significance. Results:Four hundred thirty-one patients met inclusion criteria. The univariate analysis identified a statistically significant correlation between 25 foot walk and the following variables: age, best/worst visual acuity, best/worst corrected macular volume, best corrected ganglion cell layer, and best/worst corrected retinal nerve fiber layer thickness. The multivariate analysis identified age and best corrected macular volume to be significant predictors of walking speed. The walking speed increased 0.876 ft/s with every one unit increase in macular volume. Conclusions:This was a unique study to correlate findings on OCT with walking speed in patients with MS or CIS. It indicated that degeneration of the retina (particularly macular volume) in MS/CIS predicted slower walking speed. Disclosure: Dr. Seay has nothing to disclose. Dr. Fan has nothing to disclose. Dr. Bermel has received personal compensation for activities with Biogen Idec., Novartis, Teva, Genzyme and Questcor.
Drift-correcting self-calibration for visual-inertial SLAM

We present a solution for online simultaneous localization and mapping (SLAM) self-calibration in the presence of drift in calibration parameters in order to support accurate long-term operation. Calibration parameters such as the camera focal length or camera-to-IMU extrinsics are frequently subject to drift over long periods of operation, inducing cumulative error in the reconstruction. The key contributions are modeling calibration parameters as a spatiotemporal quantity: sensor-to-sensor spatial calibration and sensor intrinsic parameters are continuously time-varying, with statistical tests for change detection and regression. An analysis of the long term effects of inappropriately modeling time-varying sensor calibration is also provided. Constant-time operation is achieved by selecting only a fixed number of informative segments of the trajectory for calibration parameter estimation, giving the added benefit of avoiding early linearization errors by not rolling past measurements into a prior distribution. Our approach is validated with simulated and real-world data.
Yersinia enterocolitica Bloodstream Infection

An elderly male presented with abdominal pain and constipation. He was diagnosed with Yersinia enterocolitica bloodstream infection associated with an abdominal aortic aneurysm and synthetic endovascular graft. This demonstrates a rare but known complication of Y. enterocolitica bloodstream infection. J Med Cases. 2017;8(11):359-360 doi: https://doi.org/10.14740/jmc2931w
CRT-700.12 3D Printing and Computer Modeling to Predict Paravalvular Leak in Transcatheter Aortic Valve Replacement

Paravalvular regurgitation (PVL) is common after transcatheter aortic valve replacement (TAVR) and associated with worse long-term outcomes when moderate or severe. Three patients undergoing TAVR for severe, calcific aortic stenosis and at risk for PVL had Pre-TAVR CT images analyzed and segmented
Solution Based Synthesis of Cs4PbBr6 Perovskite Particles with High Luminescence and Stability

Low dimensional lead halide perovskite particles are of tremendous interest due to their size-tunable band gaps, low exciton binding energy, high absorption coefficients, outstanding quantum and photovoltaic efficiencies. Herein we report a new solution-based synthesis of stabilized Cs4PbBr6 perovskite particles with high luminescence. This method requires only mild conditions and produces colloidal particles that are ideal for highly efficient solution-based device fabrications. The synthesized microstructures not only display outstanding luminescence quantum yield but also long term stability in atmospheric conditions. Partial halide substitutions were also demonstrated to extend photoluminescence spectra of the perovskite particles. This convenient synthesis and optical tunability of Cs4PbBr6 perovskite particles will be advantageous for future applications of optoelectronic advices.
AIDS: Challenges to Epidemiology in the 1990s

In the global fight against AIDS, epidemiology has played an extremely important and unusually visible role. The early history of AIDS research was dominated by the science of epidemiology, which was so rapidly and successfully applied to the AIDS problem that it became possible to develop a rational prevention strategy well before the causative agent of the disease was identified. Nevertheless, as the pandemic and efforts to understand and control it have advanced over the last decade, it may be useful to reassess the role and contribution of epidemiology to the AIDS field. Through a discussion of the epidemology of sexual transmission of HIV, this chapter will explore some of the ways in which epidemiological practice and methodology have been challenged by the HIV/AIDS pandemic.
The Multiplier Algebras M p (Γ), and the Theorem of Zafran

For 1 ≤ p < ∞, consider the Banach space of functions on the integer group Z, $${L^{P}}{\left( T \right)^{ \wedge }} = \left\{ {\hat{f}:f \in {L^{P}}\left( T \right)} \right\},$$ with norm $$ \parallel \hat{f}{\parallel _{{{L^{P}}{{\left( T\right)}^{ \wedge }}}}} = \parallel f{\parallel _{{{L^{P}}\left( T \right).}}} $$
Semi-Parametric Estimates of Intra-Lata Demand Elasticities

In most states, including recently in California and Hawaii, state public utility commissions (PUCs) have moved towards competition in the market for intra-LATA toll services1. Since the rates charged by the local exchange carriers (LECs) for toll services in these states were substantially above cost, deregulation has meant a substantial drop in intra-LATA toll rates. The PUCs in these states have allowed the LECs to recover revenue lost from lower rates in the toll market by raising local tariffs.
Public perception of pharmacist-prescribed self-administered non-emergency hormonal contraception: An analysis of online social discourse.

Abstract Background Increasing access to hormonal contraception reduces unintended pregnancies. One strategy gaining momentum is allowing patients to access hormonal contraception directly from pharmacists. Commentary on online news articles provides a naturalistic and real-time data source to assess public perceptions on timely and often controversial issues. Objective Characterize public perceptions of pharmacist-prescribed self-administered non-emergency hormonal contraception using comments posted in response to online news articles. Methods Retrospective, cross-sectional, mixed methods analysis of public comments posted in response to articles published by major media outlets between January 1 to December 31, 2015 on pharmacist-prescribed hormonal contraception. Comments were then extracted and reviewed through a two-step process to identify emerging themes using a thematic analysis. Results A total of 1060 public online comments were collected from eight articles. Of these, 757 comments (71.4%) were not related to pharmacist-prescribed hormonal contraception. Thematic analysis of the 303 relevant comments (28.6%) identified three overarching messages. First, a wide variety of reasons for how pharmacist-prescribed hormonal contraception improves healthcare and/or supports patient preferences were cited, but there was no consensus on the primary vantage. Second, individuals have varying opinions about the role of the pharmacist which creates both opportunities and challenges for pharmacist-prescribed hormonal contraception. Third, practical and logistical considerations will need to be addressed by healthcare systems, pharmacies, and payers prior to and alongside implementation. Conclusion Commenters were generally positive and cited several benefits, such as increasing access to healthcare, reducing unintended pregnancies, and supporting individual autonomy. However, it was acknowledged that these benefits would need to be balanced with potential safety concerns and logistical issues associated with delivering clinical services in a community pharmacy setting. Study results can help understand public concerns and may be useful in addressing barriers hindering public acceptance of expanded pharmacist roles.
Barney Carroll: the conscience of psychiatry

Credit: Duke University A pioneer in biological psychiatry, more recently Bernard Carroll (‘‘Barney’’) became a withering critic of its compromised ethics and corruption by industry. Shortly before his death, he helped prepare this obituary—his last chance to help correct the perverse incentives that too often influence the conduct and reporting of scientific research. Barney’s scientific contribution to psychiatric research was to introduce neuroendocrine techniques. He independently discovered the value of the dexamethasone suppression test (DST) as a biomarker of melancholia—the classic, biologically driven subtype of depression. This was the first, and remains one of very few, biomarkers in psychiatry. Barney’s 1981 paper on the DST was among the most highly cited papers in psychiatry. Its impact was immediate, with many replications and extensions. Another of Barney’s enduring contributions was to educate colleagues in the discipline of proper clinical decision making. He clarified the Bayesian principle that context counts—that is, prior conditional probabilities greatly influence the utility of any clinical feature or laboratory test in making a diagnosis. Throughout medicine, biomarkers and clinical diagnostic features perform with much greater utility in high risk groups than in general populations. Barney criticised the Diagnostic and Statistical Manual for innumerate failures to clarify the performance of diagnostic criteria and pointed out that candidate biomarkers often outperformed accepted symptomatic diagnostic criteria. A rigorous scientific …
Seismic investigation of icy crust covering subsurface oceans of Europa and Ganymede: Preliminary assessment of hypothetical experiment using impactor

Abstract Jupiter's satellite Europa is believed to harbor a global ocean beneath its ice-covered surface. But the thickness of this ice, despite its significance to the habitability of this moon, is unknown: estimates range from as thin as hundreds of meters to as thick as tens of kilometers. In this paper, we investigate the feasibility of a hypothetical experiment in which the ice's thickness is measured via seismic analysis. The assumed scenario calls for a seismometer to be placed on the satellite's surface to detect the ice surface's seismic response induced by an artificial impact event. Our hypothetical experiment could be applied at Europa as well as at Ganymede. For both satellites, two impact scenarios are considered: a low-energy-impact case, in which an orbiter probe impacts the ice at the end of the mission, and a high-energy-impact case, in which a spent upper rocket stage impacts the ice upon Jupiter arrival. We find that an impactor-induced seismic investigation is a promising add-on experiment in future missions to the icy moons of Jupiter.
An Integrated Review of Cannabis and Cannabinoids in Adult Oncologic Pain Management.

Abstract Objective The objective of this paper is to review the available literature regarding the use of cannabis and cannabinoids in adult oncologic pain management. Design and Data Sources A integrative review was conducted on March 1, 2018 using PubMed, MEDLINE, CINAHL, Embase, and Scopus. A snowball method was used to extract studies included in systematic reviews that were not included in the primary literature search. Review Method Articles reviewed address the use of cannabinoids or cannabis for pain management in oncology patients, either as stand- alone or adjuvant therapy. Results The final number of articles included is nine articles. Of the nine studies reviewed, eight reviewed the effect of the cannabinoid THC on cancer pain, and one study reviewed the use of medicinally available whole plant cannabis. The following study types were included: multiple multi-center, randomized, placebo- controlled trials and two prospective observational survey studies. Results and Conclusions Of the eight studies that reviewed the effect of the cannabinoid THC, five found THC to be more effective than placebo, one found THC to be more effective than placebo in American patients but ineffective in patients from other countries, and two found THC to be no more effective than placebo. The study that reviewed the effect of the whole plant cannabis found that there was a significant decrease in pain among those patients smoking cannabis. Nursing Practice Implications The lack of evidence in this field of research suggests a need to change policy surrounding cannabis research.
Successful Implementation of an Antibiotic Stewardship Program in an Academic Dental Practice.

Background Most antibiotic use in the United States occurs in the outpatient setting, and 10% of these prescriptions are generated by dentists. The development of comprehensive antibiotic stewardship programs (ASPs) in the dental setting is nascent, and therefore we describe the implementation of a dental ASP. Methods A collaborative team of dentist, pharmacist, and physician leaders conducted a baseline needs assessment and literature evaluation to identify opportunities to improve antibiotic prescribing by dentists within Illinois' largest oral health care provider for Medicaid recipients. A multimodal intervention was implemented that included patient and provider education, clinical guideline development, and an assessment of the antibiotic prescribing rate per urgent care visit before and after the educational interventions. Results We identified multiple needs, including standardization of antibiotic prescribing practices for patients with acute oral infections in the urgent care clinics. A 72.9% decrease in antibiotic prescribing was observed in urgent care visits after implementation of our multimodal intervention (preintervention urgent care prescribing rate, 8.5% [24/283]; postintervention, 2.3% [8/352]; P < .001). Conclusions We report the successful implementation of a dental ASP that is concordant with the Centers for Disease Control and Prevention Core Elements of Antibiotic Stewardship in the Outpatient Setting. Our approach may be adapted to other dental practices to improve antibiotic prescribing.
Minority Stress and Suicidal Behavior: Investigating a Protective Model Through Resilience in a Bisexual Sample

AbstractSuicidal behaviors are a serious public health concern in the bisexual community. Protective models are needed to guide culturally informed methods of prevention. The current study evaluate...
Continuous Dynamic Modeling of Regulated Cell Adhesion: Sorting, Intercalation, and Involution.

Abstract Cell-cell adhesion is essential for tissue growth and multicellular pattern formation and crucial for the cellular dynamics during embryogenesis and cancer progression. Understanding the dynamical gene regulation of cell adhesion molecules (CAMs) responsible for the emerging spatial tissue behaviors is a current challenge because of the complexity of these nonlinear interactions and feedback loops at different levels of abstraction—from genetic regulation to whole-organism shape formation. To extend our understanding of cell and tissue behaviors due to the regulation of adhesion molecules, here we present a novel, to our knowledge, model for the spatial dynamics of cellular patterning, growth, and shape formation due to the differential expression of CAMs and their regulation. Capturing the dynamic interplay between genetic regulation, CAM expression, and differential cell adhesion, the proposed continuous model can explain the complex and emergent spatial behaviors of cell populations that change their adhesion properties dynamically because of inter- and intracellular genetic regulation. This approach can demonstrate the mechanisms responsible for classical cell-sorting behaviors, cell intercalation in proliferating populations, and the involution of germ layer cells induced by a diffusing morphogen during gastrulation. The model makes predictions on the physical parameters controlling the amplitude and wavelength of a cellular intercalation interface, as well as the crucial role of N-cadherin regulation for the involution and migration of cells beyond the gradient of the morphogen Nodal during zebrafish gastrulation. Integrating the emergent spatial tissue behaviors with the regulation of genes responsible for essential cellular properties such as adhesion will pave the way toward understanding the genetic regulation of large-scale complex patterns and shapes formation in developmental, regenerative, and cancer biology.
Mixing Physical Organic Chemistry with Monomer Design Gives New Recyclable Materials

In this issue of Chem, Lu and co-workers report the critical role of gem-dimethyl substituents to modulate the reversibility of thiolactone polymerization. Penicillamine-derived monomers lead to a highly versatile polymer platform that enables progress toward the development of new materials for establishing a circular monomer economy.
Das hegemoniale Projekt der Bertelsmann Stiftung im Wachstumsdiskurs

Der folgende Beitrag untersucht die Position der Bertelsmann Stiftung im Wachstumsdiskurs. Der Forschende stutzt sich dabei auf die Traditionslinien des Marxismus, des Poststrukturalismus, sowie der Hegemonietheorie nach Ernesto Laclau und Chantal Mouffe. Diese theoretischen Voruberlegungen werden mithilfe der Heuristik Martin Nonhoffs, der Grounded Theory Methodology und der Lexikometrie methodisch angewandt. Auf diesem Weg rekonstruiert der Forschende das hegemoniale Projekt, das um den Knotenpunkt des Inklusiven Wachstums aufgebaut wird und in dem die okologische Nachhaltigkeit ausgeschlossen wird. Resumierend kritisiert er den affirmativen Charakter der Hegemonieanalyse.
Reduced Axial Scan Length Coronary Calcium Scoring Reduces Radiation Dose and Provides Adequate Clinical Decision-Making Before Coronary CT Angiography.

Extensive coronary artery calcium (CAC) diminishes the accuracy of coronary computed tomography angiography (CCTA). Many imagers adjust CCTA acquisition parameters depending on a preCCTA Agatston CAC score to optimize diagnostic accuracy. Typical preCCTA CAC imaging adds considerably to radiation exposure, partially attributable to imaging beyond the area known for highest CAC, the proximal coronary arteries. We aimed to determine whether a z-axis reduced scan length (RSL) would identify the majority of CAC and provide adequate information to computed tomography angiography providers relative to a standard full-scan length (FSL) preCCTA noncontrast CT. We retrospectively examined 200 subjects. The mean CAC scores detected in RSL and FSL were 77.4 (95% CI 50.6 to 104.3) and 93.9 (95% CI 57.3 to 130.5), respectively. RSL detected 81% of the FSL CAC. Among false negatives, with no CAC detected in RSL, FSL CAC severity was minimal (mean score 2.8). There was high concordance, averaging 88%, between CCTA imaging parameter adjustment decisions made by 2 experienced imagers based on either RSL or FSL. CAC detected and decision concordance decreased with increasing CAC burden. CAC detected was lower, and false negatives were more common in the right coronary artery owing to its anatomic course, placing larger segments outside RSL. Axial scan length and effective dose decreased 59% from FSL (∼14.5 cm/∼1.1 mSv) to RSL (∼5.9 cm/∼0.45 mSv). This retrospective study suggests that RSL identifies most CAC, results in similar CCTA acquisition parameter modifications, and reduces radiation exposure. Our colleagues corroborated these results in a recently published prospective study.
International Rickettsia Disease Surveillance: An Example of Cooperative Research to Increase Laboratory Capability and Capacity for Risk Assessment of Rickettsial Outbreaks Worldwide

Cooperative research that addresses infectious disease surveillance and outbreak investigations relies heavily on availability and effective use of appropriate diagnostic tools, including serological and molecular assays, as exemplified by the current COVID-19 pandemic. In this paper, we stress the importance of using these assays to support collaborative epidemiological studies to assess risk of rickettsial disease outbreaks among international partner countries. Workforce development, mentorship, and training are important components in building laboratory capability and capacity to assess risk of and mitigate emerging disease outbreaks. International partnerships that fund cooperative research through mentoring and on-the-job training are successful examples for enhancing infectious disease surveillance. Cooperative research studies between the Naval Medical Research Center's Rickettsial Diseases Research Program (RDRP) and 17 institutes from nine countries among five continents were conducted to address the presence of and the risk for endemic rickettsial diseases. To establish serological and molecular assays in the collaborative institutes, initial training and continued material, and technical support were provided by RDRP. The laboratory methods used in the research studies to detect and identify the rickettsial infections included (1) group-specific IgM and IgG serological assays and (2) molecular assays. Twenty-six cooperative research projects performed between 2008 and 2020 enhanced the capability and capacity of 17 research institutes to estimate risk of rickettsial diseases. These international collaborative studies have led to the recognition and/or confirmation of rickettsial diseases within each of the partner countries. In addition, with the identification of specific pathogen and non-pathogen Rickettsia species, a more accurate risk assessment could be made in surveillance studies using environmental samples. The discoveries from these projects reinforced international cooperation benefiting not only the partner countries but also the scientific community at large through presentations (n = 40) at international scientific meetings and peer-reviewed publications (n = 18). The cooperative research studies conducted in multiple international institutes led to the incorporation of new SOPs and trainings for laboratory procedures; biosafety, biosurety, and biosecurity methods; performance of rickettsia-specific assays; and the identification of known and unknown rickettsial agents through the introduction of new serologic and molecular assays that complemented traditional microbiology methods.
The Jury Refuser

A weird word comes to us from Joliet, Quebec, located in the country to the north of us. It is a small town lying some 40 miles northeast of Montreal. The local constabulary was on the loose, chasing down any adult citizens they could reach – in order to impress them for duty as jurors.
Pre-clinical assessment of phosphokinase activity by an anti-phosphor-tyrosine antibody labeled with In-111

1190 Objectives It is crucial to predict the selection of patients who may benefit from targeted treatment using non-invasive imaging technique. This study was aimed to determine whether Bcr-Abl non-receptor tyrosine kinase could be assessed by using Indium-111 labeled anti-phospho-tyrosine antibody (APT). Methods Ethylenedicysteine (EC) was conjugated to either APT or bovine serum albumin (BSA) using sulfo-N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide HCl as coupling agents. After dialysis, EC-APT was labeled with Indium (111In). To determine if 111In-EC-APT could be used to assess a non-receptor tyrosine kinase, in human CML K562 xenografts. Human chronic myelogenous leukemia cell line K562 was selected because it expresses a high level of the non-receptor tyrosine kinase Bcr-Abl. Gamma scintigraphy of the tumor-bearing mice administered with 111In-EC-APT (a positive control) and 111In-EC-BSA (a negative control) (100 μCi/mouse, iv) before and after Imatinib treatment was obtained at 24 and 48 hrs. Changes in the expression of phosphorylated Bcr-Abl of tumor specimen were determined by western blot analysis. Results 111In-EC-APT is preferentially taken up by tumor cells when compared to 111In-EC-BSA control. The optimal imaging time was at 24 and 48 hours after injection of 111In-EC-APT. Imatinib treatment resulted in decreased tumor volume and decreased expression of phosphorylated Bcr-Abl by western blot analysis. Bcr-Abl positive tumor uptake changes after Imantinib treatment could be assessed by 111In-EC-APT. The imaging findings did correlate with tumor response. Conclusions The results inidcate that 111In-EC-APT could assess tumor phosphokinase activity in our animal model. 111In-EC-APT may provide early evidence of response in phosphokinase levels after treatment with a kinase inhibitor
Hardy Spaces, Besov Spaces, and Triebel–Lizorkin Spaces

The main function spaces we study in this chapter are Hardy spaces which measure smoothness within the realm of rough distributions. Hardy spaces also serve as a substitute for L p when p < 1. We also take a quick look at Besov–Lipschitz and Triebel–Lizorkin spaces, which provide an appropriate framework that unifies the subject of function spaces.
Question answer TARA: a terrorism activity resource application

Terrorism research has lately become a national priority. Researchers and citizens alike are coming to grips with obtaining relevant and pertinent information from vast storehouses of information gateways, dictionaries, self-authoritative websites, and sometimes obscure government information. Specific queries need to be manually sought after, or left to the mercy of search engines that are generally scoped.
Application for Selective Streaming of Video Components

Streaming of video components has become a popular form of media service on the Internet. With the advancement in recent computer and networking technologies audio-video streaming has given rise to interesting applications. But, the variable nature of the wireless medium and limited bandwidth will not lend itself easily to support audio-video streaming. In this paper, we propose an application to provide a standard interface for selective streaming of different components of the video from the server within the desired bandwidth allocation. Specifically, the application is designed for capabilities of searching and selecting the best combination of audio, and/or video files with varying resolutions to deliver a scalable, high-performance audio and/or video seamless streaming experience over the internet. This avoids undesirable throttling of data, meets desired needs, saves user bandwidth and power consumption.
Automated modular file-based distributed configuration management for Unix servers of heterogeneous applications

We describe a project to develop a configuration management solution that will allow several heterogeneous applications to access standardized common and operating system functionality in a Unix environment. The configuration requirements from several applications can be integrated on a single host. A file-based API to common functions allows applications to be modular and portable across Unix-like operating system flavors.
A Critique of Risk Modeling and Risk Assessment of Municipal Landfills Based On U.S. Environmental Protection Agency Techniques

Environmental risks are a growing public concern in America. The threat of contaminated drinking water from municipal solid waste (MSW) landfills is receiving increased attention from citizens and from the United States Environmental Protection Agency (USEPA). Examination of USEPA data collected from MSW landfills reveals approximate risks posed by these landfills. USEPA research suggests that 60% of MSW landfills present less than a 1 in 10 billion risk of cancer incidence. Another 6% pose risks less than 1 in a billion, while 17% present risks less than 1 in a million. This study addresses the USEPA risk assessment techniques and models for estimating MSW landfill risks. USEPA data for toxic constituents of landfill leachate are also analysed in order to better understand the difficulties encountered in estimating landfill risks. The study also presents a brief discussion of public perceptions of risk as they relate to communicating the USEPA landfill model results to those who might be affected.
A generalization of Farey sequences: Some exploration via the computer

Abstract A generalization of Farey sequences for higher dimensions is considered, and numerical results obtained via the computer for quadratic Farey sequences are presented.
Human services marketing: Planning and implementation

Two marketing studies were conducted with human services providers in eastern Massachusetts. Although both surveys indicated a comprehension of marketing techniques, the surveys also found a lack of understanding of marketing research. Unless marketing research is undertaken in human services, marketing efforts will merely be an unsuccessful attempted takeover of a potentially useful corporate management technique.
Potential of ground heat source systems

This paper presents a historical background of ground source heat pump technology, followed by a review of its current shortcomings. Based on these observations the author assesses the R&D needs and recommendations for future research.
CAREER DEVELOPMENT CORRELATES OF EXPRESSED AND INVENTORIED INTEREST AGREEMENT

-A new scale of expressed and inventoried interest agreement was developed from the item responses of 164 college students to the 1985 Strong-Campbell Interest Inventory of Hansen and Campbell. Scores on this scale were then correlated with eight Strong-Campbell career development scales using Pearson product-moment correlations. These scales were Academic Comfort, Introversion-Extraversion, Realistic, Investigative, Artistic, Social, Enterprising, and Conventlond. AU correlations were statistically significant; expressed and inventoried interesr ngrcement was positively relateto introversion and negatively related to the other scales
The Impact of Hybrid Dispute‐Resolution Procedures on Constituent Fairness Judgments1

The authors investigated the effects of hybrid third-party procedures on constituents' procedural and distributive fairness judgments. In Experiment 1, three independent variables were manipulated: third-party procedure (Med–Arb vs. Arb–Med), concession making during mediation (concessions vs. no concessions), and role (labor vs. management). Participants viewed Med–Arb as fairer than Arb–Med. In Experiment 2, three factors were again manipulated: third-party procedure (Med–Arb vs. Arb–Med), whether confidential information was revealed during mediation (confidential information revealed vs. not revealed), and arbitration outcomes (winning vs. losing). Results suggest that when no confidential information was revealed, Med–Arb was significantly fairer than Arb–Med, but if confidential information was revealed, then both procedures were equally fair. Results are discussed in terms of procedural design.
Synthesis of DNA, RNA, protein and glycoprotein in mitochondria of cells transformed with Rous sarcoma viruses

Summary Mitochondrial DNA and RNA synthesis in Rous sarcoma virus (RSV) transformed chick embryo fibroblast (CEF) cells pretreated with 10 mg per ml of camptothecin was elevated over that in normal CEF cells. Protein synthesis in the RSV-CEF cell mitochondria was also elevated when measured in the presence of 100 μg per ml of cycloheximide. Experiments with temperature sensitive mutants of RSV (TS-68) and RAV-CEF cells indicated the elevation in mitochondrial synthesis was directly related to cell transformation and not merely to cell viral infection. In related experiments, isolated pure mitochondrial preparations from the RSV-CEF cells synthesized greater amounts of glycoprotein autonomously than normal uninfected CEF controls.
Going off the dole: a prudential and ethical critique of the healthfare state.

The present ‘healthfare’ state in the United States in neither practically nor morally justified. The nation currently fails to provide adequate access to health care for tens of millions of uninsured citizens. To suggest that the United States' half-million physicians should provide their care as charity is an inadequate solution. The transfer of assets from the ‘haves’ to the ‘have-nots’ through taxation in a ‘healthfare state’ undermines human compassion, and fails to respect minimal moral requirements. However, alternative strategies are possible. During the next 20 years health care could come to be financed on the basis of sound quasi-libertarian moral and prudential principles. In the interim deliberate political action is required to achieve novel health policy, available and affordable job and career training, and universal employment. It is possible to achieve universal access to adequate health care while sustaining individual choice, and at the same time to reduce or virtually eliminate taxpayersubsidised health care. This approach would, in time, eliminate the healthfare state and eventually encourage and even require citizens to go off the healthfare dole.
Interconnect and lumped elements modeling in interior penalty discontinuous Galerkin time-domain methods

In this paper, we present an approach on how to incorporate passive lumped elements such as resistors, capacitors and inductors in DGTD methods and their application to interconnect modeling. Starting from the voltage and current relationships, we derive the equivalent relationships that describe each of the R, L, C in terms of the electric and magnetic fields. Next, these field expressions are weakly enforced through the Interior Penalty (IP) DG formulation. The proposed method is explicit and conditionally stable. Additionally, a local time-stepping strategy is applied to increase efficiency and reduce the computational time. Finally, a numerical example is presented to validate the proposed approach.
The Natural Environment and Economic Education

The specialty area of environmental and resource economics is engaging the attention of an increasing number of economic educators. In this article, Christainsen reviews and evaluates some of the major textbooks from the perspective of the role of property rights in theory and in policy issues.
Brain Metastases from Renal Cell Carcinoma in the Era of Tyrosine Kinase Inhibitors

Abstract Background The effectiveness of tyrosine kinase inhibitors (TKI) in preventing brain metastases in patients with renal cell carcinoma is unclear. Methods Preclinical studies were conducted to determine the steady-state brain and plasma concentrations of sorafenib and sunitinib in mice deficient in the drug efflux transporters; p-glycoprotein, and breast cancer resistance protein. A single-institution retrospective analysis of patients treated from 2008 to 2010 was conducted to assess the incidence of brain metastases before and during TKI treatment. Results Transport of sorafenib and sunitinib across the blood-brain barrier was restricted. Retrospective analysis revealed that the median time to develop metastatic brain disease was 28 months (range, 1-108 months) while on TKI therapy and 11.5 months (range, 0-64 months) in patients who did not receive TKI therapy. The incidence of brain metastases per month in patients not treated with TKI therapy was 1.6 higher than the incidence in patients treated with TKI therapy. Conclusions Penetration of sorafenib or sunitinib through an intact blood-brain barrier to brain tissue is limited; however, the incidence of brain metastases per unit time is decreased in patients on TKI therapy in comparison with the “cytokine” era.
Wiedemann-Franz law in the quantum limit for isotropic scattering

Abstract A temperature gradient is introduced into the density matrix equation by analogy with the Boltzmann transport equation. The electric and heat currents are defined in the case of isotropic scattering, in which particular case, it is shown that the Wiedemann-Franz law holds even in the details of the oscillations of both the electric and thermal conductivities.
Familiarity with the Hyperbilirubinemia Guideline Increases Knowledge of Management † 638

Background: The effectiveness of clinical practice guidelines(CPG) as a strategy to change and improve care remains uncertain. Objective: To assess whether familiarity with American Academy of Pediatrics (AAP) CPGs in general, and with the AAP hyperbilirubinemia CPG in particular, is associated with knowledge of the assessment and treatment(including follow-up) of hyperbilirubinemia. Design: Written survey of clinicians at six sites, representing two pediatric emergency departments(ED), two hospital-based practices (HBP), and two office-based private practices (PP). Outcome measure: Percent of questions answered correctly about the assessment (19), treatment and follow-up (7), and overall knowledge (mean of the two subscores) of hyperbilirubinemia. Independent measures: Years since graduation, involvement in quality improvement (QI) activities, attitudes toward CPGs, familiarity with AAP CPGs, familiarity with the AAP hyperbilirubinemia CPG, practice type, provider type(attending, fellow, resident, and nurse practitioner) and experience with newborns. Results: Of 233 eligible clinicians, 186 (79.8%) responded. 42% of clinicians reported familiarity with the AAP hyperbilirubinemia CPG (65% of PP clinicians, 57% of ED clinicians, and 35% of HBP clinicians). Clinicians reporting familiarity with the hyperbilirubinemia CPG achieved higher scores on overall knowledge (p=0.0006) and treatment(p=0.0019). No other independent measure was associated with overall knowledge. After controlling for all other independent measures, familiarity with the AAP hyperbilirubinemia CPG remained associated with overall knowledge(p=0.0066). Assessment score was related to practice (p=0.0001) and provider(p=0.0060) type, while treatment score was related to provider type (p=0.03) as well as familiarity with the AAP hyperbilirubinemia CPG. Conclusions: Reported familiarity with the AAP hyperbilirubinemia CPG is associated with increased knowledge. The findings that knowledge subscores varied by provider and practice type suggest that CPG dissemination and educational approaches should be tailored to particular practice settings. Additional study should also examine whether knowledge relates to actual clinical practice.
Perioperative management of a patient scheduled for bilateral hand transplant

The perioperative management of a patient receiving a bilateral hand transplant is presented. The anesthetic management required careful fluid administration, homeothermic temperature maintenance, and postoperative analgesia. The role of different anesthesia subspecialties is highlighted.
Child safety programs: implications affecting use of child restraints

Automobile deaths have been identified as the leading cause of death for children between the ages of one and fourteen. Those children who are unrestrained as passengers are at particularly high risk to injury and death. School health and safety programs need to include an understanding of this problem and implement efforts to increase restraint usage. A study of parental seatbelt and child passenger restraint use was conducted to identify frequency of use and behavioral and attitudinal factors influencing use of child restraints. Self-reported data of drivers seatbelt use at all times was 19.0%, and the use of a child restraining device was 49.6%. Data recorded in a previous observational study noted a driver seatbelt usage rate of 14.2% and use of a child restraining device at 25.6%. Major reasons for non-use of seatbelts by drivers included discomfort and restricted movement. Reasons for non-use of child restraints focused upon the dislike and discomfort of the child for the restraint.
Measurement of children's health

Measuring child health has become a more pressing issue in the face of high rates of survival of childhood illnesses, often with residual chronic health conditions or impairments; the growing awareness of child behavioral and mental health morbidity; the focus on the importance of assessing therapeutic interventions and outcomes; and increased awareness of the multiple ways in which child health influences later adult health conditions. There is widespread belief that the perfect all-purpose measure can be developed and that researchers have not yet succeeded in doing so. This paper addresses three kinds of challenges to the measurement of child health that hamper the development of measures and make it likely that one size will not fit all. These include a series of fundamental underlying assumptions about health and its measurement, issues unique to assessing the health of children, and unresolved controversies that relate to the lens through which to assess child health.
Methane hydrate equilibrium and formation kinetics in the presence of an anionic surfactant

This paper presents a new thermodynamic calculation procedure to predict gas hydrate equilibria in the presence of sodium dodecyl sulfate (SDS) micelles. This calculation procedure employs the Poisson−Boltzmann equation to determine the electrical potential and the water chemical potential change due to the presence of micelles. This water chemical potential change is incorporated into the Zele−Lee−Holder and Lee−Holder distortion model to predict equilibrium conditions of gas hydrates in the micelle solution. The prediction results agree with experimental results within an error of 5−20%. Both results show that the equilibrium dissociation pressures of methane hydrates at SDS concentrations ranging from 250 to 10 000 ppm are not much different from those in the absence of SDS. However, the initial formation rate of methane hydrates is greatly affected by SDS. One useful finding is that there is an optimal SDS concentration for the maximum initial formation rate.
Body and soul: the Black Panther Party and the fight against medical discrimination

The activism of the Black Panther Party (BPP) is often reduced, through a selective lens of militancy, to its message of self-defense and/or violent confrontations with law enforcement. In Body and...
Complications and surgical revision for failed disc arthroplasty

This review will outline the indications and options for revision of failed disc arthroplasty. Such indications may include implant loosening, malposition, displacement, early wear, and infection. Each indication will likely require different preoperative planning, testing, and strategies.
The Theory of International Values Re-examined

The classical theorists on international values guilty of an overabstraction which led them into error. — Mill's exposition turns on an exceptional rather than a normal case, 56. — Bastable errs in the presentation of this exceptional case, 59. — Both lay down corollaries some of which are true only in exceptional circumstances and others not true at all, 59. — The logic of exports and imports, 63. — Trading situations involving several countries and commodities; conclusions alien to currently accepted theory, 70. — Conclusion, in a series of negative and positive propositions, 83.
Precursors in the biosynthesis of pelargonidin 3-glucoside

Abstract Acetic acid-1- 14 C, cinnamic acid-β- 14 C, cinnamic acid-α- 14 C, D -glucose-U- 14 C, D -fructose-U- 14 C, DL -phenylalanine-(ring labelled)- 14 C, DL -phenylalanine-COOH- 14 C, quinic acid-U- 14 C, shikimic acid-U- 14 C and L -tyrosine-U- 14 C were administered to detached strawberries and the incorporation of the label into the anthocyanin was measured. Cinnamic and shikimic acids were the most efficient precursors followed by the sugars, phenylalanine, quinic acid, acetic acid and tyrosine. Degradation of the labelled pigment indicated that ring A can be formed from acetic acid, glucose or fructose, ring B from cinnamic acid, shikimic acid, quinic acid, phenylalanine, tyrosine, glucose or fructose, and the sugar moiety of the pigment from acetic acid, shikimic acid, glucose or fructose. Evidence was obtained that the C 6 -C 3 skeleton of cinnamic acid and phenylalanine was incorporated intact.
The lactic acid response to alkalosis in panic disorder : an integrative review.

Panic patients consistently show exaggerated lactic acid response to alkalosis, whether produced by hyperventilation or by sodium lactate infusion. Understanding why this occurs may provide important clues to the pathogenesis of panic disorder. Although brain hypoxia from excessive hypocapnia-induced cerebral vasoconstriction is often cited as the mechanism of elevated brain lactic acid in panic disorder, studies of brain metabolism show that hypocapnia rarely leads to brain hypoxia. Increased lactic acid production is a normal response to intracellular alkalosis and to intracellular cyclic AMP. Thus, other possible mechanisms of the exaggerated lactic acid response in panic disorder include a disturbance of mechanisms regulating intracellular pH and factors increasing intracellular cyclic AMP. Both mechanisms are consistent with the suffocation false alarm theory of panic disorder. This review suggests a theoretical framework for future magnetic resonance spectroscopy studies that can test some of the predictions of these competing models.
A testable hypothesis about schizophrenia generated by evolutionary theory

Abstract A specific hypothesis about schizophrenia, which is generated by an application to behavior of the Darwinian theory of evolution by natural selection, is presented. For reasons that are developed herein, the hypothesis was derived from the known behavioral-physiology differences between nocturnal and diurnal mammals. The hypothesis is being published prior to its testing to facilitate the acceptance or rejection of the specific evolutionary-derived theory from which it was drawn and also to focus attention on the more basic, yet often clinically ignored, question, "What is schizophrenia?"
The ultrastructure ofAcetivibrio cellulolyticus, a recently isolated cellulolytic anaerobe

The surface and internal structure of air-dried, freeze-dried, or critical-point-dried cells ofAcetivibrio cellulolyticus were determined by negative staining, and by scanning and transmission electron microscopy. The cell wall has five layers, the outermost being the widest. This outermost layer is soft and amorphous, adsorbs cellulose microfibrils, and shows projections of tenuous appearance. Results of staining with heavy ions indicate that the outermost layer carries a net positive charge. The flagellum is a tubular, uniform extension of this outermost layer, about, 20 nm in diameter and approximately 6.4 μm long, with no visible internal details or basal body. The inner layers of the wall show no fine structure, other than differences in electron opacity. The cytoplasm is composed of a mixture of densely staining spheres and smaller globules in a background of fine particles. These particles are not completely destroyed by fixation with KMnO4, which indicates that they are low in ribonucleic acid. There is no evidence for membranes around or outside of any of these bodies.